Taurus_UMD|evm.model.AC_000158.1.2 Q9BQI4 CCDC3_HUMAN 95.000 0.819444 0.266667 CCDC3 - Coiled-coil domain-containing protein 3 precursor - Homo sapiens (Human) - CCDC3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (PubMed:25193116). Positively regulates lipid accumulation in adipose cells (By similarity). Taurus_UMD|evm.model.AC_000158.1.3 Q8NGL2 OR5L1_HUMAN 45.318 0.991266 0.736334 OR5L1 - Olfactory receptor 5L1 - Homo sapiens (Human) - OR5L1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000158.1.4 Q9Y696 CLIC4_HUMAN 77.682 0.353659 2.59289 CLIC4 - Chloride intracellular channel protein 4 - Homo sapiens (Human) - CLIC4 gene Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Taurus_UMD|evm.model.AC_000158.1.5 P53805 RCAN1_HUMAN 61.983 0.879699 0.527778 RCAN1 - Calcipressin-1 - Homo sapiens (Human) - RCAN1 gene Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity). Taurus_UMD|evm.model.AC_000158.1.6 Q5R6X7 CBX3_PONAB 91.803 0.989011 0.994536 CBX3 - Chromobox protein homolog 3 - Pongo abelii (Sumatran orangutan) - CBX3 gene Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs). Taurus_UMD|evm.model.AC_000158.1.8 Q6XXM7 RCAN1_SHEEP 100.000 0.989899 1.00508 RCAN1 - Calcipressin-1 - Ovis aries (Sheep) - RCAN1 gene Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Taurus_UMD|evm.model.AC_000158.1.9 Q9XSP1 KCNE1_FELCA 79.365 0.961538 1.00775 KCNE1 - Potassium voltage-gated channel subfamily E member 1 - Felis catus (Cat) - KCNE1 gene Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Taurus_UMD|evm.model.AC_000158.1.10 Q5E975 TM230_BOVIN 80.833 0.982143 0.933333 TMEM230 - Transmembrane protein 230 - Bos taurus (Bovine) - TMEM230 gene Involved in trafficking and recycling of synaptic vesicles. Taurus_UMD|evm.model.AC_000158.1.11 P0DPE8 SM34B_HUMAN 68.750 0.888112 1.02878 SMIM34B - Small integral membrane protein 34B - Homo sapiens (Human) - SMIM34B gene Taurus_UMD|evm.model.AC_000158.1.12 F1MIW6 FA243_BOVIN 100.000 0.992063 1.00398 FAM243 - Protein FAM243 - Bos taurus (Bovine) - FAM243 gene Taurus_UMD|evm.model.AC_000158.1.13 P82931 RT06_BOVIN 94.783 0.797203 1.15323 MRPS6 - 28S ribosomal protein S6, mitochondrial - Bos taurus (Bovine) - MRPS6 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit rRNA binding, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000158.1.14 P53793 SC5A3_BOVIN 99.304 0.997218 1.00139 SLC5A3 - Sodium/myo-inositol cotransporter - Bos taurus (Bovine) - SLC5A3 gene Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function. Taurus_UMD|evm.model.AC_000158.1.15 P13621 ATPO_BOVIN 100.000 0.728522 1.3662 ATP5PO - ATP synthase subunit O, mitochondrial precursor - Bos taurus (Bovine) - ATP5PO gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Taurus_UMD|evm.model.AC_000158.1.16 Q15811 ITSN1_HUMAN 96.556 0.998789 0.959326 ITSN1 - Intersectin-1 - Homo sapiens (Human) - ITSN1 gene Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688). Taurus_UMD|evm.model.AC_000158.1.17 Q59A28 QORL1_BOVIN 95.082 0.950521 1.10029 CRYZL1 - Quinone oxidoreductase-like protein 1 - Bos taurus (Bovine) - CRYZL1 gene Taurus_UMD|evm.model.AC_000158.1.18 Q9NYP3 DONS_HUMAN 83.039 0.89694 1.09717 DONSON - Protein downstream neighbor of Son - Homo sapiens (Human) - DONSON gene Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. Taurus_UMD|evm.model.AC_000158.1.19 Q9QX47 SON_MOUSE 98.289 0.166124 1.00491 Son - Protein SON - Mus musculus (Mouse) - Son gene RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3' (By similarity). Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (By similarity). May also regulate the ghrelin signaling in hypothalamic neuron by acting as a negative regulator of GHSR expression (PubMed:20876580). Taurus_UMD|evm.model.AC_000158.1.20 Q59A32 PUR2_BOVIN 100.000 0.998022 1.00099 GART - Trifunctional purine biosynthetic protein adenosine-3 - Bos taurus (Bovine) - GART gene cytosol, phosphoribosylamine-glycine ligase activity, phosphoribosylformylglycinamidine cyclo-ligase activity, adenine biosynthetic process, purine nucleotide biosynthetic process Taurus_UMD|evm.model.AC_000158.1.21 Q9NX36 DJC28_HUMAN 82.895 0.994751 0.981959 DNAJC28 - DnaJ homolog subfamily C member 28 - Homo sapiens (Human) - DNAJC28 gene May have a role in protein folding or as a chaperone. Taurus_UMD|evm.model.AC_000158.1.23 Q5R4C3 TM50B_PONAB 100.000 0.987421 1.00633 TMEM50B - Transmembrane protein 50B - Pongo abelii (Sumatran orangutan) - TMEM50B gene Taurus_UMD|evm.model.AC_000158.1.24 P38484 INGR2_HUMAN 64.516 0.827957 1.10386 IFNGR2 - Interferon gamma receptor 2 precursor - Homo sapiens (Human) - IFNGR2 gene Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114,PubMed:7615558). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114). Taurus_UMD|evm.model.AC_000158.1.25 Q04790 INAR1_BOVIN 100.000 0.996435 1.00179 IFNAR1 - Interferon alpha/beta receptor 1 precursor - Bos taurus (Bovine) - IFNAR1 gene Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:8318540). Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). Taurus_UMD|evm.model.AC_000158.1.26 Q95141 INAR2_BOVIN 99.421 0.590183 1.65283 IFNAR2 - Interferon alpha/beta receptor 2 precursor - Bos taurus (Bovine) - IFNAR2 gene Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway. Directly involved in signal transduction through its association with the TYR kinase JAK1. Involved in interferon-mediated STAT1, STAT2 and STAT3 activation. Taurus_UMD|evm.model.AC_000158.1.28 Q6WV90 H4_MYTGA 97.087 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000158.1.29 Q8TAK6 OLIG1_HUMAN 86.182 0.992509 0.98524 OLIG1 - Oligodendrocyte transcription factor 1 - Homo sapiens (Human) - OLIG1 gene Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity). Taurus_UMD|evm.model.AC_000158.1.30 Q13516 OLIG2_HUMAN 95.708 0.805556 0.891641 OLIG2 - Oligodendrocyte transcription factor 2 - Homo sapiens (Human) - OLIG2 gene Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. Taurus_UMD|evm.model.AC_000158.1.31 P24049 RL17_RAT 64.815 0.929293 0.538043 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000158.1.32 Q9NYP8 CU062_HUMAN 78.082 0.990868 1 C21orf62 - Uncharacterized protein C21orf62 precursor - Homo sapiens (Human) - C21orf62 gene Taurus_UMD|evm.model.AC_000158.1.33 Q9Y5B6 PAXB1_HUMAN 96.320 0.997833 1.00654 PAXBP1 - PAX3- and PAX7-binding protein 1 - Homo sapiens (Human) - PAXBP1 gene Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity). Taurus_UMD|evm.model.AC_000158.1.34 O18964 SYNJ1_BOVIN 93.168 0.822478 1.18278 SYNJ1 - Synaptojanin-1 - Bos taurus (Bovine) - SYNJ1 gene Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (PubMed:9199318). Taurus_UMD|evm.model.AC_000158.1.37 P57076 CF298_HUMAN 93.103 0.993127 1.00345 CFAP298 - Cilia- and flagella-associated protein 298 - Homo sapiens (Human) - CFAP298 gene Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:24094744). Seems to be important for initiation rather than maintenance of cilium motility (By similarity). Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity). May suppress canonical Wnt signaling activity (By similarity). Taurus_UMD|evm.model.AC_000158.1.38 Q68US5 EVA1C_PANTR 88.662 0.995475 1.00227 EVA1C - Protein eva-1 homolog C precursor - Pan troglodytes (Chimpanzee) - EVA1C gene Binds heparin. Taurus_UMD|evm.model.AC_000158.1.39 O60287 NPA1P_HUMAN 77.871 0.995154 0.99956 URB1 - Nucleolar pre-ribosomal-associated protein 1 - Homo sapiens (Human) - URB1 gene fibrillar center, nucleolus, RNA binding, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000158.1.40 Q68UT4 MRAP_PANTR 79.348 0.65942 0.802326 MRAP - Melanocortin-2 receptor accessory protein - Pan troglodytes (Chimpanzee) - MRAP gene Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity). Taurus_UMD|evm.model.AC_000158.1.41 A5D7N9 MS18A_BOVIN 100.000 0.991525 1.00426 MIS18A - Protein Mis18-alpha - Bos taurus (Bovine) - MIS18A gene Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. Taurus_UMD|evm.model.AC_000158.1.43 Q96PC5 MIA2_HUMAN 32.673 0.573964 0.359065 MIA2 - Melanoma inhibitory activity protein 2 precursor - Homo sapiens (Human) - MIA2 gene Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:27138255, PubMed:21525241, PubMed:25202031, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). Taurus_UMD|evm.model.AC_000158.1.44 Q5XHI9 HUNKA_XENLA 89.021 0.451613 1.0767 hunk-a - Hormonally up-regulated neu tumor-associated kinase homolog A - Xenopus laevis (African clawed frog) - hunk-a gene Taurus_UMD|evm.model.AC_000158.1.45 O95104 SCAF4_HUMAN 92.167 0.998252 0.997384 SCAF4 - SR-related and CTD-associated factor 4 - Homo sapiens (Human) - SCAF4 gene Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF8, also acts as a suppressor of transcriptional readthrough (PubMed:31104839). Taurus_UMD|evm.model.AC_000158.1.46 P00442 SODC_BOVIN 98.462 0.741379 1.14474 SOD1 - Superoxide dismutase [Cu-Zn] - Bos taurus (Bovine) - SOD1 gene Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Taurus_UMD|evm.model.AC_000158.1.49 Q923D2 BLVRB_MOUSE 82.353 0.434783 0.558252 Blvrb - Flavin reductase (NADPH) - Mus musculus (Mouse) - Blvrb gene Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. Taurus_UMD|evm.model.AC_000158.1.50 P79103 RS4_BOVIN 82.927 0.856115 0.528517 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000158.1.51 Q6R648 KR111_CAPHI 91.195 0.9875 1.00629 KRTAP11-1 - Keratin-associated protein 11-1 - Capra hircus (Goat) - KRTAP11-1 gene In the wool cortex, wool keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of wool keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant wool shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of wool keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Taurus_UMD|evm.model.AC_000158.1.52 Q28580 KRA71_SHEEP 94.253 0.977273 1.03529 KRTAP7-1 - Keratin-associated protein 7-1 - Ovis aries (Sheep) - KRTAP7-1 gene In the wool cortex, wool keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant wool shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of wool keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Taurus_UMD|evm.model.AC_000158.1.69 Q02958 KRA61_SHEEP 95.349 0.6 0.843373 KRTAP6-1 - Keratin-associated protein 6-1 - Ovis aries (Sheep) - KRTAP6-1 gene In the wool cortex, wool keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant wool shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of wool keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Taurus_UMD|evm.model.AC_000158.1.72 Q02958 KRA61_SHEEP 80.769 0.6 1.0241 KRTAP6-1 - Keratin-associated protein 6-1 - Ovis aries (Sheep) - KRTAP6-1 gene In the wool cortex, wool keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant wool shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of wool keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Taurus_UMD|evm.model.AC_000158.1.84 Q52KI8 SRRM1_MOUSE 69.930 0.337461 0.341438 Srrm1 - Serine/arginine repetitive matrix protein 1 - Mus musculus (Mouse) - Srrm1 gene Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. Taurus_UMD|evm.model.AC_000158.1.85 Q5R5Q2 SRRM1_PONAB 76.730 0.985075 0.146129 SRRM1 - Serine/arginine repetitive matrix protein 1 - Pongo abelii (Sumatran orangutan) - SRRM1 gene Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. Taurus_UMD|evm.model.AC_000158.1.86 Q8IUC0 KR131_HUMAN 61.404 0.987879 0.959302 KRTAP13-1 - Keratin-associated protein 13-1 - Homo sapiens (Human) - KRTAP13-1 gene In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Taurus_UMD|evm.model.AC_000158.1.87 Q8IUC0 KR131_HUMAN 63.462 0.974522 0.912791 KRTAP13-1 - Keratin-associated protein 13-1 - Homo sapiens (Human) - KRTAP13-1 gene In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Taurus_UMD|evm.model.AC_000158.1.88 Q3LI81 KR271_HUMAN 62.245 0.955446 0.975845 KRTAP27-1 - Keratin-associated protein 27-1 - Homo sapiens (Human) - KRTAP27-1 gene In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Taurus_UMD|evm.model.AC_000158.1.89 Q6PEX3 KR261_HUMAN 49.048 0.983425 0.861905 KRTAP26-1 - Keratin-associated protein 26-1 - Homo sapiens (Human) - KRTAP26-1 gene In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Taurus_UMD|evm.model.AC_000158.1.90 Q3LI83 KR241_HUMAN 65.748 0.778816 1.26378 KRTAP24-1 - Keratin-associated protein 24-1 - Homo sapiens (Human) - KRTAP24-1 gene In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Taurus_UMD|evm.model.AC_000158.1.91 Q9Z260 CLD8_MOUSE 86.667 0.99115 1.00444 Cldn8 - Claudin-8 - Mus musculus (Mouse) - Cldn8 gene Tight-junction protein required for paracellular chloride transport in the kidney (PubMed:20921420, PubMed:25831548). Mediates recruitment of CLDN4 to tight junction in the kidney (PubMed:20921420, PubMed:25831548). Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Taurus_UMD|evm.model.AC_000158.1.92 P56750 CLD17_HUMAN 78.667 0.99115 1.00893 CLDN17 - Claudin-17 - Homo sapiens (Human) - CLDN17 gene Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability. Taurus_UMD|evm.model.AC_000158.1.93 Q38PU4 GRIK1_MACFA 95.491 0.960887 0.835512 GRIK1 - Glutamate receptor ionotropic, kainate 1 precursor - Macaca fascicularis (Crab-eating macaque) - GRIK1 gene Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus (By similarity). Taurus_UMD|evm.model.AC_000158.1.94 P22756 GRIK1_RAT 94.118 0.428571 0.206533 Grik1 - Glutamate receptor ionotropic, kainate 1 precursor - Rattus norvegicus (Rat) - Grik1 gene Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Taurus_UMD|evm.model.AC_000158.1.95 O14867 BACH1_HUMAN 81.016 0.997305 1.00815 BACH1 - Transcription regulator protein BACH1 - Homo sapiens (Human) - BACH1 gene Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498). Taurus_UMD|evm.model.AC_000158.1.96 P58500 M3KCL_MOUSE 61.538 0.493927 1.73944 Map3k7cl - MAP3K7 C-terminal-like protein - Mus musculus (Mouse) - Map3k7cl gene Taurus_UMD|evm.model.AC_000158.1.97 Q3ZCI9 TCPQ_BOVIN 100.000 0.996357 1.00182 CCT8 - T-complex protein 1 subunit theta - Bos taurus (Bovine) - CCT8 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Taurus_UMD|evm.model.AC_000158.1.98 Q08DA3 UBP16_BOVIN 100.000 0.997582 1.00121 USP16 - Ubiquitin carboxyl-terminal hydrolase 16 - Bos taurus (Bovine) - USP16 gene Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. Taurus_UMD|evm.model.AC_000158.1.100 Q5R9U9 RWD2B_PONAB 85.517 0.993127 0.912226 RWDD2B - RWD domain-containing protein 2B - Pongo abelii (Sumatran orangutan) - RWDD2B gene Taurus_UMD|evm.model.AC_000158.1.101 O94822 LTN1_HUMAN 89.864 0.972988 1.02718 LTN1 - E3 ubiquitin-protein ligase listerin - Homo sapiens (Human) - LTN1 gene E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). Taurus_UMD|evm.model.AC_000158.1.102 A0A2R8Y619 H2BE1_HUMAN 85.246 0.98374 1.0082 H2BE1 - Histone H2B type 2-E1 - Homo sapiens (Human) - H2BE1 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000158.1.103 Q9Y5N5 N6MT1_HUMAN 90.654 0.990698 1.00467 N6AMT1 - Methyltransferase N6AMT1 - Homo sapiens (Human) - N6AMT1 gene Methyltransferase that can methylate proteins and, to a lower extent, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583, PubMed:31636962, PubMed:31061526). Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators (PubMed:31061526). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146, PubMed:31632689, PubMed:31636962). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:18539146, PubMed:20606008, PubMed:31636962, PubMed:31061526). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PubMed:21193388, PubMed:25997655). It however only plays a limited role in arsenic metabolism compared with AS3MT (PubMed:25997655). Taurus_UMD|evm.model.AC_000158.1.104 Q9UPS8 ANR26_HUMAN 37.739 0.97807 0.266667 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000158.1.108 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000158.1.109 Q9UNA0 ATS5_HUMAN 91.221 0.997861 1.00538 ADAMTS5 - A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor - Homo sapiens (Human) - ADAMTS5 gene Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (By similarity). Participates in development of brown adipose tissue and browning of white adipose tissue (By similarity). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection. Taurus_UMD|evm.model.AC_000158.1.110 Q9UHI8 ATS1_HUMAN 82.227 0.99794 1.00414 ADAMTS1 - A disintegrin and metalloproteinase with thrombospondin motifs 1 precursor - Homo sapiens (Human) - ADAMTS1 gene Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. Taurus_UMD|evm.model.AC_000158.1.111 Q8VIH7 CYYR1_MOUSE 81.818 0.313953 1.04242 Cyyr1 - Cysteine and tyrosine-rich protein 1 precursor - Mus musculus (Mouse) - Cyyr1 gene Taurus_UMD|evm.model.AC_000158.1.112 Q95241 A4_SAISC 97.603 0.99734 1.00133 APP - Amyloid-beta A4 protein precursor - Saimiri sciureus (Common squirrel monkey) - APP gene Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP (By similarity). Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction (By similarity). In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity). Taurus_UMD|evm.model.AC_000158.1.113 Q06546 GABPA_HUMAN 98.678 0.995604 1.0022 GABPA - GA-binding protein alpha chain - Homo sapiens (Human) - GABPA gene Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. Taurus_UMD|evm.model.AC_000158.1.114 P02721 ATP5J_BOVIN 100.000 0.699346 1.41667 ATP5PF - ATP synthase-coupling factor 6, mitochondrial precursor - Bos taurus (Bovine) - ATP5PF gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes. Taurus_UMD|evm.model.AC_000158.1.115 P57087 JAM2_HUMAN 90.747 0.936455 1.00336 JAM2 - Junctional adhesion molecule B precursor - Homo sapiens (Human) - JAM2 gene Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed:11590146, PubMed:11823489, PubMed:24357068). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed:24357068). At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed:12239159). Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed:12070135). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). May also play a role in angiogenesis (By similarity). Taurus_UMD|evm.model.AC_000158.1.116 Q9NYK5 RM39_HUMAN 87.164 0.994048 0.994083 MRPL39 - 39S ribosomal protein L39, mitochondrial - Homo sapiens (Human) - MRPL39 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, RNA binding, mitochondrial translational elongation, mitochondrial translational termination Taurus_UMD|evm.model.AC_000158.1.121 Q8IX95 CTGE3_HUMAN 38.144 0.548193 1.05063 CTAGE3P - Putative cTAGE family member 3 - Homo sapiens (Human) - CTAGE3P gene Tumor-associated antigen. Taurus_UMD|evm.model.AC_000158.1.122 Q80SU7 GVIN1_MOUSE 68.263 0.954023 0.0716934 Gvin1 - Interferon-induced very large GTPase 1 - Mus musculus (Mouse) - Gvin1 gene Taurus_UMD|evm.model.AC_000158.1.124 O15394 NCAM2_HUMAN 95.874 0.9821 1.00119 NCAM2 - Neural cell adhesion molecule 2 precursor - Homo sapiens (Human) - NCAM2 gene May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons. Taurus_UMD|evm.model.AC_000158.1.125 Q10126 YSM6_CAEEL 25.625 0.755319 0.673835 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000158.1.126 P98072 ENTK_BOVIN 93.394 0.974737 0.917874 TMPRSS15 - Enteropeptidase precursor - Bos taurus (Bovine) - TMPRSS15 gene Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. Taurus_UMD|evm.model.AC_000158.1.127 Q9H9P2 CHODL_HUMAN 97.070 0.992701 1.00366 CHODL - Chondrolectin precursor - Homo sapiens (Human) - CHODL gene May play a role in the development of the nervous system such as in neurite outgrowth and elongation. May be involved in motor axon growth and guidance. Taurus_UMD|evm.model.AC_000158.1.128 Q9NYK6 EURL_HUMAN 89.562 0.980132 1.01684 EURL - Protein EURL homolog - Homo sapiens (Human) - EURL gene Plays a role in cortical progenitor cell proliferation and differentiation. Promotes dendritic spine development of post-migratory cortical projection neurons by modulating the beta-catenin signaling pathway. Taurus_UMD|evm.model.AC_000158.1.129 A4UTQ2 BTG3_PIG 96.825 0.926199 1.0754 BTG3 - Protein BTG3 - Sus scrofa (Pig) - BTG3 gene Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase. Taurus_UMD|evm.model.AC_000158.1.130 Q8WMV3 CXAR_BOVIN 100.000 0.994536 1.00274 CXADR - Coxsackievirus and adenovirus receptor homolog precursor - Bos taurus (Bovine) - CXADR gene Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair (By similarity). Taurus_UMD|evm.model.AC_000158.1.131 Q9NY97 B3GN2_HUMAN 90.991 0.909091 0.304786 B3GNT2 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 - Homo sapiens (Human) - B3GNT2 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. Taurus_UMD|evm.model.AC_000158.1.132 Q96P65 QRFPR_HUMAN 89.441 0.714286 0.519722 QRFPR - Pyroglutamylated RF-amide peptide receptor - Homo sapiens (Human) - QRFPR gene Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels. Taurus_UMD|evm.model.AC_000158.1.133 P62137 PP1A_MOUSE 100.000 0.993958 1.00303 Ppp1ca - Serine/threonine-protein phosphatase PP1-alpha catalytic subunit - Mus musculus (Mouse) - Ppp1ca gene Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates CENPA (By similarity). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (By similarity). Taurus_UMD|evm.model.AC_000158.1.134 Q9UHP3 UBP25_HUMAN 94.424 0.91895 0.830332 USP25 - Ubiquitin carboxyl-terminal hydrolase 25 - Homo sapiens (Human) - USP25 gene Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains. Taurus_UMD|evm.model.AC_000158.1.137 P48552 NRIP1_HUMAN 87.651 0.998271 0.999136 NRIP1 - Nuclear receptor-interacting protein 1 - Homo sapiens (Human) - NRIP1 gene Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). Taurus_UMD|evm.model.AC_000158.1.138 Q9NSI8 SAMN1_HUMAN 85.791 0.99455 0.983914 SAMSN1 - SAM domain-containing protein SAMSN-1 - Homo sapiens (Human) - SAMSN1 gene Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity). Taurus_UMD|evm.model.AC_000158.1.139 Q2TBX4 HSP13_BOVIN 100.000 0.995726 0.993631 HSPA13 - Heat shock 70 kDa protein 13 precursor - Bos taurus (Bovine) - HSPA13 gene Has peptide-independent ATPase activity. Taurus_UMD|evm.model.AC_000158.1.140 P33527 MRP1_HUMAN 47.537 0.982253 0.846506 ABCC1 - Multidrug resistance-associated protein 1 - Homo sapiens (Human) - ABCC1 gene Mediates export of organic anions and drugs from the cytoplasm (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity). Taurus_UMD|evm.model.AC_000158.1.141 Q80YT9 RBM11_MOUSE 75.107 0.668588 1.45798 Rbm11 - Splicing regulator RBM11 - Mus musculus (Mouse) - Rbm11 gene Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 (By similarity). Taurus_UMD|evm.model.AC_000158.1.144 O46415 FRIL_BOVIN 89.714 0.987952 0.948571 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000158.1.147 Q9Y6N7 ROBO1_HUMAN 97.121 0.988235 0.978195 ROBO1 - Roundabout homolog 1 precursor - Homo sapiens (Human) - ROBO1 gene Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). Taurus_UMD|evm.model.AC_000158.1.148 A8WYE4 PAR1_CAEBR 46.429 0.181818 0.414522 par-1 - Serine/threonine-protein kinase par-1 - Caenorhabditis briggsae - par-1 gene Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote. Regulates mes-1 expression during early embryogenesis. Critical role in postembryonic vulval morphogenesis. Taurus_UMD|evm.model.AC_000158.1.149 Q8CHG5 AREL1_MOUSE 86.567 0.204969 0.391252 Arel1 - Apoptosis-resistant E3 ubiquitin protein ligase 1 - Mus musculus (Mouse) - Arel1 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation (By similarity). Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome (PubMed:31578312). Taurus_UMD|evm.model.AC_000158.1.151 Q32PA9 FKBP2_BOVIN 87.770 0.945205 1.04286 FKBP2 - Peptidyl-prolyl cis-trans isomerase FKBP2 precursor - Bos taurus (Bovine) - FKBP2 gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Taurus_UMD|evm.model.AC_000158.1.152 Q6T308 GLGB_FELCA 95.324 0.756831 0.523605 GBE1 - 1,4-alpha-glucan-branching enzyme - Felis catus (Cat) - GBE1 gene Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule. Taurus_UMD|evm.model.AC_000158.1.153 Q8N149 LIRA2_HUMAN 42.986 0.757785 0.598344 LILRA2 - Leukocyte immunoglobulin-like receptor subfamily A member 2 precursor - Homo sapiens (Human) - LILRA2 gene Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061). Taurus_UMD|evm.model.AC_000158.1.154 Q86YS3 RFIP4_HUMAN 80.519 0.873563 0.136578 RAB11FIP4 - Rab11 family-interacting protein 4 - Homo sapiens (Human) - RAB11FIP4 gene Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. Taurus_UMD|evm.model.AC_000158.1.156 Q6F5E8 CARL2_HUMAN 89.803 0.904478 0.233449 CARMIL2 - Capping protein, Arp2/3 and myosin-I linker protein 2 - Homo sapiens (Human) - CARMIL2 gene Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26578515, PubMed:26466680). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26578515, PubMed:26466680). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647349, PubMed:27647348, PubMed:28112205). Taurus_UMD|evm.model.AC_000158.1.157 Q8N3J6 CADM2_HUMAN 90.097 0.994667 0.862069 CADM2 - Cell adhesion molecule 2 precursor - Homo sapiens (Human) - CADM2 gene Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. Taurus_UMD|evm.model.AC_000158.1.158 Q58CU4 ZDH16_BOVIN 81.679 0.849673 0.405836 ZDHHC16 - Palmitoyltransferase ZDHHC16 - Bos taurus (Bovine) - ZDHHC16 gene Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (By similarity). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity). Taurus_UMD|evm.model.AC_000158.1.160 P85442 VGLL3_MOUSE 89.362 0.993939 1.01227 Vgll3 - Transcription cofactor vestigial-like protein 3 - Mus musculus (Mouse) - Vgll3 gene May act as a specific coactivator for the mammalian TEFs. Taurus_UMD|evm.model.AC_000158.1.162 Q3SX42 CHM2B_BOVIN 100.000 0.990654 1.00469 CHMP2B - Charged multivesicular body protein 2b - Bos taurus (Bovine) - CHMP2B gene Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity). Taurus_UMD|evm.model.AC_000158.1.163 P10036 PIT1_BOVIN 91.483 0.993711 1.09278 POU1F1 - Pituitary-specific positive transcription factor 1 - Bos taurus (Bovine) - POU1F1 gene Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. Taurus_UMD|evm.model.AC_000158.1.164 P30939 5HT1F_HUMAN 94.809 0.99455 1.00273 HTR1F - 5-hydroxytryptamine receptor 1F - Homo sapiens (Human) - HTR1F gene G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Taurus_UMD|evm.model.AC_000158.1.165 Q9UFW8 CGBP1_HUMAN 100.000 0.988095 1.00599 CGGBP1 - CGG triplet repeat-binding protein 1 - Homo sapiens (Human) - CGGBP1 gene Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. Taurus_UMD|evm.model.AC_000158.1.167 Q8IZM8 ZN654_HUMAN 90.722 0.513705 1.94664 ZNF654 - Zinc finger protein 654 - Homo sapiens (Human) - ZNF654 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000158.1.168 Q0VCL9 CC038_BOVIN 99.681 0.795918 1.2524 Uncharacterized protein C3orf38 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000158.1.169 A0A1B0GTH6 CS2IP_HUMAN 58.728 0.986226 0.989101 CSNKA2IP - Casein kinase II subunit alpha'-interacting protein - Homo sapiens (Human) - CSNKA2IP gene May play a role in chromatin regulation of male germ cells. Taurus_UMD|evm.model.AC_000158.1.171 P29320 EPHA3_HUMAN 96.560 0.896907 0.493388 EPHA3 - Ephrin type-A receptor 3 precursor - Homo sapiens (Human) - EPHA3 gene Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. Taurus_UMD|evm.model.AC_000158.1.172 P07224 PROS_BOVIN 96.000 0.996974 0.979259 PROS1 - Vitamin K-dependent protein S precursor - Bos taurus (Bovine) - PROS1 gene Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. Taurus_UMD|evm.model.AC_000158.1.173 Q3SXY8 AR13B_HUMAN 88.140 0.995349 1.00467 ARL13B - ADP-ribosylation factor-like protein 13B - Homo sapiens (Human) - ARL13B gene Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidence is required to confirm these data. Taurus_UMD|evm.model.AC_000158.1.174 Q0P5D8 NSUN3_BOVIN 100.000 0.9941 1.00296 NSUN3 - tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial - Bos taurus (Bovine) - NSUN3 gene Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position. mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation. Taurus_UMD|evm.model.AC_000158.1.175 Q8VCD7 KDM4C_MOUSE 80.645 0.252101 0.112903 Kdm4c - Lysine-specific demethylase 4C - Mus musculus (Mouse) - Kdm4c gene Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Taurus_UMD|evm.model.AC_000158.1.177 P62630 EF1A1_RAT 89.205 0.531915 0.712121 Eef1a1 - Elongation factor 1-alpha 1 - Rattus norvegicus (Rat) - Eef1a1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000158.1.178 P68370 TBA1A_RAT 97.339 0.984683 1.0133 Tuba1a - Tubulin alpha-1A chain - Rattus norvegicus (Rat) - Tuba1a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Taurus_UMD|evm.model.AC_000158.1.179 Q9UF33 EPHA6_HUMAN 97.842 0.900541 0.892857 EPHA6 - Ephrin type-A receptor 6 precursor - Homo sapiens (Human) - EPHA6 gene Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). Taurus_UMD|evm.model.AC_000158.1.180 Q0IIM2 ARL6_BOVIN 100.000 0.989305 1.00538 ARL6 - ADP-ribosylation factor-like protein 6 - Bos taurus (Bovine) - ARL6 gene Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization (By similarity). Taurus_UMD|evm.model.AC_000158.1.181 Q80W49 CRBG3_MOUSE 82.016 0.347452 2.88955 Crybg3 - Beta/gamma crystallin domain-containing protein 3 - Mus musculus (Mouse) - Crybg3 gene protein-containing complex, protein kinase A binding, structural constituent of eye lens, lens development in camera-type eye, visual perception Taurus_UMD|evm.model.AC_000158.1.182 Q5EA24 RIOX2_BOVIN 100.000 0.860075 1.16017 RIOX2 - Ribosomal oxygenase 2 - Bos taurus (Bovine) - RIOX2 gene Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles (By similarity). Taurus_UMD|evm.model.AC_000158.1.183 P50573 GBRR3_RAT 84.615 0.995736 1.01078 Gabrr3 - Gamma-aminobutyric acid receptor subunit rho-3 precursor - Rattus norvegicus (Rat) - Gabrr3 gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Taurus_UMD|evm.model.AC_000158.1.184 P0C628 O5AC1_HUMAN 76.871 0.986532 0.967427 OR5AC1 - Olfactory receptor 5AC1 - Homo sapiens (Human) - OR5AC1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000158.1.186 P0C628 O5AC1_HUMAN 73.881 0.992537 0.436482 OR5AC1 - Olfactory receptor 5AC1 - Homo sapiens (Human) - OR5AC1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000158.1.191 P0DN80 OR5H8_HUMAN 65.529 0.995951 0.801948 OR5H8 - Olfactory receptor 5H8 - Homo sapiens (Human) - OR5H8 gene Odorant receptor. Taurus_UMD|evm.model.AC_000158.1.192 A6NKK0 OR5H1_HUMAN 80.488 0.920455 0.28115 OR5H1 - Olfactory receptor 5H1 - Homo sapiens (Human) - OR5H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000158.1.193 A6NKK0 OR5H1_HUMAN 78.523 0.954839 0.495208 OR5H1 - Olfactory receptor 5H1 - Homo sapiens (Human) - OR5H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000158.1.195 A6NET4 OR5K3_HUMAN 75.214 0.891473 0.401869 OR5K3 - Olfactory receptor 5K3 - Homo sapiens (Human) - OR5K3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000158.1.196 A6NET4 OR5K3_HUMAN 79.808 0.990431 0.65109 OR5K3 - Olfactory receptor 5K3 - Homo sapiens (Human) - OR5K3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000158.1.197 Q32PH1 CDCA7_BOVIN 98.795 0.97619 0.224599 CDCA7 - Cell division cycle-associated protein 7 - Bos taurus (Bovine) - CDCA7 gene Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator (By similarity). Taurus_UMD|evm.model.AC_000158.1.198 Q32PH1 CDCA7_BOVIN 95.804 0.972414 0.387701 CDCA7 - Cell division cycle-associated protein 7 - Bos taurus (Bovine) - CDCA7 gene Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator (By similarity). Taurus_UMD|evm.model.AC_000158.1.199 Q5RDV7 CLDN1_PONAB 95.257 0.909747 1.09486 CLDND1 - Claudin domain-containing protein 1 - Pongo abelii (Sumatran orangutan) - CLDND1 gene Taurus_UMD|evm.model.AC_000158.1.200 O97663 GPR15_MACMU 85.833 0.983471 1.00833 GPR15 - G-protein coupled receptor 15 - Macaca mulatta (Rhesus macaque) - GPR15 gene Probable chemokine receptor. SIV-1 coreceptor. Taurus_UMD|evm.model.AC_000158.1.201 P36551 HEM6_HUMAN 85.651 0.993333 0.991189 CPOX - Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial precursor - Homo sapiens (Human) - CPOX gene Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. Taurus_UMD|evm.model.AC_000158.1.202 P42577 FRIS_LYMST 39.583 0.715736 1.13218 Soma ferritin - Lymnaea stagnalis (Great pond snail) Taurus_UMD|evm.model.AC_000158.1.204 Q6H8M7 SIA10_BOVIN 100.000 0.967742 1.03021 ST3GAL6 - Type 2 lactosamine alpha-2,3-sialyltransferase - Bos taurus (Bovine) - ST3GAL6 gene Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity). Taurus_UMD|evm.model.AC_000158.1.205 Q96PD2 DCBD2_HUMAN 91.142 0.997436 1.00645 DCBLD2 - Discoidin, CUB and LCCL domain-containing protein 2 precursor - Homo sapiens (Human) - DCBLD2 gene cell surface, integral component of plasma membrane, intracellular receptor signaling pathway, negative regulation of cell growth, wound healing Taurus_UMD|evm.model.AC_000158.1.206 P16423 POLR_DROME 29.474 0.765182 0.23368 pol - Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM - Drosophila melanogaster (Fruit fly) - pol gene Taurus_UMD|evm.model.AC_000158.1.208 P14282 CO8A1_RABIT 94.362 0.997319 1.00269 COL8A1 - Collagen alpha-1(VIII) chain precursor - Oryctolagus cuniculus (Rabbit) - COL8A1 gene Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). Taurus_UMD|evm.model.AC_000158.1.209 Q4L180 FIL1L_HUMAN 92.908 0.993811 0.996476 FILIP1L - Filamin A-interacting protein 1-like - Homo sapiens (Human) - FILIP1L gene Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. Taurus_UMD|evm.model.AC_000158.1.210 Q2T9Y1 CC026_BOVIN 100.000 0.425497 2.16487 Uncharacterized protein C3orf26 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000158.1.211 Q2T9P5 CC50C_BOVIN 100.000 0.994186 1.00292 TMEM30C - Cell cycle control protein 50C - Bos taurus (Bovine) - TMEM30C gene endoplasmic reticulum, Golgi apparatus, plasma membrane, phospholipid translocation Taurus_UMD|evm.model.AC_000158.1.212 Q9NUY8 TBC23_HUMAN 97.000 0.997147 1.00286 TBC1D23 - TBC1 domain family member 23 - Homo sapiens (Human) - TBC1D23 gene Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). Taurus_UMD|evm.model.AC_000158.1.213 Q2T9R6 NIT2_BOVIN 99.275 0.96831 1.02899 NIT2 - Omega-amidase NIT2 - Bos taurus (Bovine) - NIT2 gene Has omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively. Taurus_UMD|evm.model.AC_000158.1.214 O94826 TOM70_HUMAN 95.731 0.996721 1.00329 TOMM70 - Mitochondrial import receptor subunit TOM70 - Homo sapiens (Human) - TOMM70 gene Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812). Taurus_UMD|evm.model.AC_000158.1.215 A1A4G5 LNP1_HUMAN 75.141 0.977778 1.01124 LNP1 - Leukemia NUP98 fusion partner 1 - Homo sapiens (Human) - LNP1 gene Taurus_UMD|evm.model.AC_000158.1.216 Q9NWC5 TM45A_HUMAN 65.283 0.956522 1.00364 TMEM45A - Transmembrane protein 45A - Homo sapiens (Human) - TMEM45A gene Taurus_UMD|evm.model.AC_000158.1.217 Q8N7U6 EFHB_HUMAN 73.381 0.939323 1.02881 EFHB - EF-hand domain-containing family member B - Homo sapiens (Human) - EFHB gene Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus. Taurus_UMD|evm.model.AC_000158.1.218 Q0IIG7 RAB5A_BOVIN 100.000 0.984496 0.6 RAB5A - Ras-related protein Rab-5A - Bos taurus (Bovine) - RAB5A gene Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:16476778) (By similarity). RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3. Taurus_UMD|evm.model.AC_000158.1.219 A8MPX8 PP2D1_HUMAN 62.102 0.897547 1.1 PP2D1 - Protein phosphatase 2C-like domain-containing protein 1 - Homo sapiens (Human) - PP2D1 gene protein serine/threonine phosphatase activity, protein dephosphorylation Taurus_UMD|evm.model.AC_000158.1.220 A2RRP1 NBAS_HUMAN 88.934 0.629534 0.162801 NBAS - Neuroblastoma-amplified sequence - Homo sapiens (Human) - NBAS gene Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). Taurus_UMD|evm.model.AC_000158.1.221 Q92831 KAT2B_HUMAN 96.175 0.987838 0.889423 KAT2B - Histone acetyltransferase KAT2B - Homo sapiens (Human) - KAT2B gene Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (PubMed:8945521). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (PubMed:8945521). Also acetylates non-histone proteins, such as ACLY, PLK4, RRP9/U3-55K and TBX5 (PubMed:9707565, PubMed:10675335, PubMed:27796307, PubMed:23932781, PubMed:26867678, PubMed:29174768). Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A (PubMed:8684459). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing (PubMed:26867678). Also acetylates spermidine (PubMed:27389534). Taurus_UMD|evm.model.AC_000158.1.222 Q5FBB7 SGO1_HUMAN 62.734 0.899824 1.01426 SGO1 - Shugoshin 1 - Homo sapiens (Human) - SGO1 gene Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. Taurus_UMD|evm.model.AC_000158.1.223 Q9NQW5 PRDM7_HUMAN 76.630 0.847575 0.880081 PRDM7 - Probable histone-lysine N-methyltransferase PRDM7 - Homo sapiens (Human) - PRDM7 gene Probable histone methyltransferase. Taurus_UMD|evm.model.AC_000158.1.224 Q8TC21 ZN596_HUMAN 72.603 0.971429 1.04167 ZNF596 - Zinc finger protein 596 - Homo sapiens (Human) - ZNF596 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000158.1.225 Q9SLC4 ATL40_ARATH 50.794 0.423611 0.663594 ATL40 - RING-H2 finger protein ATL40 - Arabidopsis thaliana (Mouse-ear cress) - ATL40 gene Taurus_UMD|evm.model.AC_000158.1.226 Q9NWC5 TM45A_HUMAN 73.585 0.956522 1.00364 TMEM45A - Transmembrane protein 45A - Homo sapiens (Human) - TMEM45A gene Taurus_UMD|evm.model.AC_000158.1.227 Q96K78 AGRG7_HUMAN 74.948 0.953722 0.623588 ADGRG7 - Adhesion G-protein coupled receptor G7 precursor - Homo sapiens (Human) - ADGRG7 gene Orphan receptor. Taurus_UMD|evm.model.AC_000158.1.228 Q92734 TFG_HUMAN 91.771 0.727103 1.3375 TFG - Protein TFG - Homo sapiens (Human) - TFG gene Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). Taurus_UMD|evm.model.AC_000158.1.229 Q7Z7G0 TARSH_HUMAN 78.378 0.380376 1.53581 ABI3BP - Target of Nesh-SH3 precursor - Homo sapiens (Human) - ABI3BP gene collagen-containing extracellular matrix, extracellular region, extracellular space Taurus_UMD|evm.model.AC_000158.1.231 A6NC97 F172B_HUMAN 85.359 0.975543 1.01657 FAM172BP - Putative protein FAM172B - Homo sapiens (Human) - FAM172BP gene nucleus, heterochromatin assembly by small RNA Taurus_UMD|evm.model.AC_000158.1.232 Q2KI45 TM10C_BOVIN 100.000 0.995316 1.00235 TRMT10C - tRNA methyltransferase 10 homolog C precursor - Bos taurus (Bovine) - TRMT10C gene Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation. Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity. The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit. The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme. In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. Taurus_UMD|evm.model.AC_000158.1.233 Q32PF3 PCNP_BOVIN 100.000 0.885 1.1236 PCNP - PEST proteolytic signal-containing nuclear protein - Bos taurus (Bovine) - PCNP gene May be involved in cell cycle regulation. Taurus_UMD|evm.model.AC_000158.1.234 O95625 ZBT11_HUMAN 92.315 0.998101 1 ZBTB11 - Zinc finger and BTB domain-containing protein 11 - Homo sapiens (Human) - ZBTB11 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000158.1.235 P83732 RL24_RAT 100.000 0.987342 1.00637 Rpl24 - 60S ribosomal protein L24 - Rattus norvegicus (Rat) - Rpl24 gene cytoplasm, cytosolic large ribosomal subunit, cytosolic ribosome, polysomal ribosome, synapse, RNA binding, structural constituent of ribosome, assembly of large subunit precursor of preribosome, cytoplasmic translation, exit from mitosis Taurus_UMD|evm.model.AC_000158.1.236 Q8IW35 CEP97_HUMAN 83.968 0.997672 0.993064 CEP97 - Centrosomal protein of 97 kDa - Homo sapiens (Human) - CEP97 gene Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome. Taurus_UMD|evm.model.AC_000158.1.237 A2VDP6 NXPE3_BOVIN 100.000 0.996429 1.00179 NXPE3 - NXPE family member 3 precursor - Bos taurus (Bovine) - NXPE3 gene Taurus_UMD|evm.model.AC_000158.1.238 Q9BE45 IKBZ_BOVIN 100.000 0.997222 1.00139 NFKBIZ - NF-kappa-B inhibitor zeta - Bos taurus (Bovine) - NFKBIZ gene Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity). Taurus_UMD|evm.model.AC_000158.1.239 Q9D2P4 URM1_MOUSE 73.585 0.583333 0.831683 Urm1 - Ubiquitin-related modifier 1 - Mus musculus (Mouse) - Urm1 gene Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. Taurus_UMD|evm.model.AC_000158.1.240 P24049 RL17_RAT 82.609 0.764045 0.483696 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000158.1.241 Q8N149 LIRA2_HUMAN 37.993 0.724771 0.677019 LILRA2 - Leukocyte immunoglobulin-like receptor subfamily A member 2 precursor - Homo sapiens (Human) - LILRA2 gene Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061). Taurus_UMD|evm.model.AC_000158.1.242 Q8TCW7 ZPLD1_HUMAN 95.422 0.971831 1.02651 ZPLD1 - Zona pellucida-like domain-containing protein 1 precursor - Homo sapiens (Human) - ZPLD1 gene Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ. Taurus_UMD|evm.model.AC_000158.1.245 Q8N448 LNX2_HUMAN 92.857 0.984252 0.184058 LNX2 - Ligand of Numb protein X 2 - Homo sapiens (Human) - LNX2 gene Taurus_UMD|evm.model.AC_000158.1.246 D0VWQ3 RL18_CANLF 42.657 0.904762 0.670213 RPL18 - Ribosomal protein L18 - Canis lupus familiaris (Dog) - RPL18 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000158.1.248 Q13191 CBLB_HUMAN 97.152 0.964637 1.03666 CBLB - E3 ubiquitin-protein ligase CBL-B - Homo sapiens (Human) - CBLB gene E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). Taurus_UMD|evm.model.AC_000158.1.249 O46414 FRIH_BOVIN 67.857 0.886179 0.679558 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000158.1.250 Q29RU3 CCD54_BOVIN 100.000 0.993921 1.00305 CCDC54 - Coiled-coil domain-containing protein 54 - Bos taurus (Bovine) - CCDC54 gene Taurus_UMD|evm.model.AC_000158.1.251 Q8WY36 BBX_HUMAN 93.312 0.97412 1.02657 BBX - HMG box transcription factor BBX - Homo sapiens (Human) - BBX gene Transcription factor that is necessary for cell cycle progression from G1 to S phase. Taurus_UMD|evm.model.AC_000158.1.253 Q9N0K1 CD47_BOVIN 99.010 0.993421 1.0033 CD47 - Leukocyte surface antigen CD47 precursor - Bos taurus (Bovine) - CD47 gene Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection (By similarity). Taurus_UMD|evm.model.AC_000158.1.254 Q5EA95 IFT57_BOVIN 100.000 0.995349 1.00233 IFT57 - Intraflagellar transport protein 57 homolog - Bos taurus (Bovine) - IFT57 gene Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear (By similarity). Taurus_UMD|evm.model.AC_000158.1.255 Q9UM44 HHLA2_HUMAN 58.696 0.910112 1.07488 HHLA2 - HERV-H LTR-associating protein 2 precursor - Homo sapiens (Human) - HHLA2 gene Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. Taurus_UMD|evm.model.AC_000158.1.256 Q9Y2K3 MYH15_HUMAN 80.485 0.938119 1.03803 MYH15 - Myosin-15 - Homo sapiens (Human) - MYH15 gene Muscle contraction. Taurus_UMD|evm.model.AC_000158.1.257 Q9BW19 KIFC1_HUMAN 64.033 0.908309 0.518574 KIFC1 - Kinesin-like protein KIFC1 - Homo sapiens (Human) - KIFC1 gene Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). Taurus_UMD|evm.model.AC_000158.1.258 Q8TCG1 CIP2A_HUMAN 89.537 0.99776 0.98674 CIP2A - Protein CIP2A - Homo sapiens (Human) - CIP2A gene Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation. Taurus_UMD|evm.model.AC_000158.1.259 Q86Y13 DZIP3_HUMAN 88.411 0.998342 0.998344 DZIP3 - E3 ubiquitin-protein ligase DZIP3 - Homo sapiens (Human) - DZIP3 gene E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA. Taurus_UMD|evm.model.AC_000158.1.260 Q3SYX1 TRAT1_BOVIN 99.482 0.989691 1.00518 TRAT1 - T-cell receptor-associated transmembrane adapter 1 - Bos taurus (Bovine) - TRAT1 gene Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. Taurus_UMD|evm.model.AC_000158.1.261 Q86VD1 MORC1_HUMAN 68.004 0.997664 0.869919 MORC1 - MORC family CW-type zinc finger protein 1 - Homo sapiens (Human) - MORC1 gene Required for spermatogenesis (By similarity). Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (By similarity). Taurus_UMD|evm.model.AC_000158.1.263 Q7Z7J5 DPPA2_HUMAN 59.058 0.572632 1.59396 DPPA2 - Developmental pluripotency-associated protein 2 - Homo sapiens (Human) - DPPA2 gene Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes. Taurus_UMD|evm.model.AC_000158.1.264 A8D8X1 RL10_SHEEP 99.533 0.990698 1.00467 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000158.1.265 Q5R931 RL10_PONAB 97.175 0.977778 0.841121 RPL10 - 60S ribosomal protein L10 - Pongo abelii (Sumatran orangutan) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000158.1.266 Q5RKI1 IF4A2_RAT 97.179 0.99375 0.786241 Eif4a2 - Eukaryotic initiation factor 4A-II - Rattus norvegicus (Rat) - Eif4a2 gene ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). Taurus_UMD|evm.model.AC_000158.1.267 A5PJL1 PXMP4_BOVIN 99.528 0.99061 1.00472 PXMP4 - Peroxisomal membrane protein 4 - Bos taurus (Bovine) - PXMP4 gene peroxisomal membrane Taurus_UMD|evm.model.AC_000158.1.268 Q1RN00 YC018_HUMAN 58.553 0.782383 0.969849 Putative uncharacterized protein LOC151760 - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000158.1.269 Q9NQS3 NECT3_HUMAN 97.012 0.961612 0.948998 NECTIN3 - Nectin-3 precursor - Homo sapiens (Human) - NECTIN3 gene Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. Taurus_UMD|evm.model.AC_000158.1.271 Q3MHP9 TACT_BOVIN 95.088 0.99633 0.95614 CD96 - T-cell surface protein tactile precursor - Bos taurus (Bovine) - CD96 gene May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation (By similarity). Taurus_UMD|evm.model.AC_000158.1.272 Q3B820 F161A_HUMAN 89.091 0.872 0.189394 FAM161A - Protein FAM161A - Homo sapiens (Human) - FAM161A gene Involved in ciliogenesis. Taurus_UMD|evm.model.AC_000158.1.273 B2RXA1 PLCX2_MOUSE 91.496 0.994135 1.00294 Plcxd2 - PI-PLC X domain-containing protein 2 - Mus musculus (Mouse) - Plcxd2 gene Taurus_UMD|evm.model.AC_000158.1.274 Q86SQ0 PHLB2_HUMAN 90.590 0.977379 1.02314 PHLDB2 - Pleckstrin homology-like domain family B member 2 - Homo sapiens (Human) - PHLDB2 gene Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). Taurus_UMD|evm.model.AC_000158.1.275 Q5E9H9 ABHDA_BOVIN 100.000 0.993485 1.00327 ABHD10 - Palmitoyl-protein thioesterase ABHD10, mitochondrial precursor - Bos taurus (Bovine) - ABHD10 gene Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate. Taurus_UMD|evm.model.AC_000158.1.276 Q3ZBY2 TAGL3_BOVIN 100.000 0.177903 5.36683 TAGLN3 - Transgelin-3 - Bos taurus (Bovine) - TAGLN3 gene Taurus_UMD|evm.model.AC_000158.1.277 Q5BVD1 TTMP_HUMAN 64.977 0.93913 1.05991 TTMP - TPA-induced transmembrane protein - Homo sapiens (Human) - TTMP gene Taurus_UMD|evm.model.AC_000158.1.278 Q8N6F7 GCSAM_HUMAN 69.832 0.988827 1.00562 GCSAM - Germinal center-associated signaling and motility protein - Homo sapiens (Human) - GCSAM gene Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. Taurus_UMD|evm.model.AC_000158.1.279 Q4G0N8 SL9C1_HUMAN 71.518 0.914403 1.03229 SLC9C1 - Sodium/hydrogen exchanger 10 - Homo sapiens (Human) - SLC9C1 gene Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity). Taurus_UMD|evm.model.AC_000158.1.280 P41217 OX2G_HUMAN 79.026 0.985075 0.964029 CD200 - OX-2 membrane glycoprotein precursor - Homo sapiens (Human) - CD200 gene Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. Taurus_UMD|evm.model.AC_000158.1.281 Q7Z6A9 BTLA_HUMAN 57.818 0.989051 0.948097 BTLA - B- and T-lymphocyte attenuator precursor - Homo sapiens (Human) - BTLA gene Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044). Taurus_UMD|evm.model.AC_000158.1.282 Q0VCL3 ATG3_BOVIN 100.000 0.993651 1.00318 ATG3 - Ubiquitin-like-conjugating enzyme ATG3 - Bos taurus (Bovine) - ATG3 gene E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway (By similarity). Taurus_UMD|evm.model.AC_000158.1.283 A6QPI1 S35A5_BOVIN 100.000 0.867076 1.15059 SLC35A5 - Probable UDP-sugar transporter protein SLC35A5 - Bos taurus (Bovine) - SLC35A5 gene integral component of Golgi membrane Taurus_UMD|evm.model.AC_000158.1.284 Q76M96 CCD80_HUMAN 85.893 0.997906 1.00526 CCDC80 - Coiled-coil domain-containing protein 80 precursor - Homo sapiens (Human) - CCDC80 gene Promotes cell adhesion and matrix assembly. Taurus_UMD|evm.model.AC_000158.1.285 A5D7V5 MO2R1_BOVIN 81.780 0.951417 0.695775 CD200R1 - Cell surface glycoprotein CD200 receptor 1 precursor - Bos taurus (Bovine) - CD200R1 gene Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli (By similarity). Taurus_UMD|evm.model.AC_000158.1.286 A5D7V5 MO2R1_BOVIN 100.000 0.994382 1.00282 CD200R1 - Cell surface glycoprotein CD200 receptor 1 precursor - Bos taurus (Bovine) - CD200R1 gene Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli (By similarity). Taurus_UMD|evm.model.AC_000158.1.287 Q0P5E7 GTPB8_BOVIN 100.000 0.99308 1.00347 GTPBP8 - GTP-binding protein 8 - Bos taurus (Bovine) - GTPBP8 gene mitochondrion Taurus_UMD|evm.model.AC_000158.1.288 Q6NW34 NEPRO_HUMAN 80.212 0.996448 0.992945 NEPRO - Nucleolus and neural progenitor protein - Homo sapiens (Human) - NEPRO gene May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development. Taurus_UMD|evm.model.AC_000158.1.289 P25787 PSA2_HUMAN 99.573 0.991489 1.00427 PSMA2 - Proteasome subunit alpha type-2 - Homo sapiens (Human) - PSMA2 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Taurus_UMD|evm.model.AC_000158.1.290 Q9BWV1 BOC_HUMAN 89.068 0.998209 1.00269 BOC - Brother of CDO precursor - Homo sapiens (Human) - BOC gene Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Taurus_UMD|evm.model.AC_000158.1.291 Q96MT7 CFA44_HUMAN 82.334 0.971068 1.02535 CFAP44 - Cilia- and flagella-associated protein 44 - Homo sapiens (Human) - CFAP44 gene Flagellar protein involved in sperm flagellum axoneme organization and function. Taurus_UMD|evm.model.AC_000158.1.292 Q2T9X8 SPICE_BOVIN 99.884 0.997677 1.00116 SPICE1 - Spindle and centriole-associated protein 1 - Bos taurus (Bovine) - SPICE1 gene Regulator required for centriole duplication. for proper bipolar spindle formation and chromosome congression in mitosis (By similarity). Taurus_UMD|evm.model.AC_000158.1.293 Q9NXL6 SIDT1_HUMAN 91.415 0.997573 0.996372 SIDT1 - SID1 transmembrane family member 1 precursor - Homo sapiens (Human) - SIDT1 gene In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. Taurus_UMD|evm.model.AC_000158.1.294 Q68DE3 USF3_HUMAN 87.100 0.999103 0.992873 USF3 - Basic helix-loop-helix domain-containing protein USF3 - Homo sapiens (Human) - USF3 gene Involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties. Taurus_UMD|evm.model.AC_000158.1.295 Q5RF28 NAA50_PONAB 100.000 0.988235 1.00592 NAA50 - N-alpha-acetyltransferase 50 - Pongo abelii (Sumatran orangutan) - NAA50 gene N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. Component of a N-alpha-acetyltransferase complex containing NAA10 and NAA15, but NAA50 does not influence the acetyltransferase activity of NAA10: this multiprotein complex probably constitutes the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides. Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10. Taurus_UMD|evm.model.AC_000158.1.296 P31404 VATA_BOVIN 100.000 0.995153 1.00324 ATP6V1A - V-type proton ATPase catalytic subunit A - Bos taurus (Bovine) - ATP6V1A gene Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in neurite development and synaptic connectivity (By similarity). Taurus_UMD|evm.model.AC_000158.1.297 P68105 EF1A1_RABIT 91.633 0.325033 1.65152 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000158.1.299 Q8IYP9 ZDH23_HUMAN 89.250 0.927907 1.05134 ZDHHC23 - Palmitoyltransferase ZDHHC23 - Homo sapiens (Human) - ZDHHC23 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (Probable). Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. Taurus_UMD|evm.model.AC_000158.1.300 Q8NCU4 CC191_HUMAN 78.907 0.993435 0.976496 CCDC191 - Coiled-coil domain-containing protein 191 - Homo sapiens (Human) - CCDC191 gene Taurus_UMD|evm.model.AC_000158.1.301 Q9H974 QTRT2_HUMAN 91.807 0.995192 1.00241 QTRT2 - Queuine tRNA-ribosyltransferase accessory subunit 2 - Homo sapiens (Human) - QTRT2 gene Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Taurus_UMD|evm.model.AC_000158.1.302 P52703 DRD3_CHLAE 90.250 0.995012 1.0025 DRD3 - D(3) dopamine receptor - Chlorocebus aethiops (Green monkey) - DRD3 gene Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000158.1.303 Q495A1 TIGIT_HUMAN 65.182 0.991803 1 TIGIT - T-cell immunoreceptor with Ig and ITIM domains precursor - Homo sapiens (Human) - TIGIT gene Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Taurus_UMD|evm.model.AC_000158.1.304 Q9HC78 ZBT20_HUMAN 97.973 0.908979 1.09717 ZBTB20 - Zinc finger and BTB domain-containing protein 20 - Homo sapiens (Human) - ZBTB20 gene May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (PubMed:11352661). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). Taurus_UMD|evm.model.AC_000158.1.305 Q3SYR7 RL9_BOVIN 90.625 0.988764 0.927083 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000158.1.306 P06836 NEUM_BOVIN 100.000 0.866906 1.14876 GAP43 - Neuromodulin - Bos taurus (Bovine) - GAP43 gene This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity). Taurus_UMD|evm.model.AC_000158.1.309 Q3T062 RRP15_BOVIN 96.552 0.770053 0.653846 RRP15 - RRP15-like protein - Bos taurus (Bovine) - RRP15 gene preribosome, large subunit precursor, maturation of 5.8S rRNA, maturation of LSU-rRNA Taurus_UMD|evm.model.AC_000158.1.312 Q08DK1 IGS11_BOVIN 99.771 0.619318 1.61098 IGSF11 - Immunoglobulin superfamily member 11 precursor - Bos taurus (Bovine) - IGSF11 gene Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (By similarity). Taurus_UMD|evm.model.AC_000158.1.313 Q96M34 TEX55_HUMAN 39.963 0.898167 0.916045 TEX55 - Testis-specific expressed protein 55 - Homo sapiens (Human) - TEX55 gene nucleus Taurus_UMD|evm.model.AC_000158.1.314 P38573 UPK1B_BOVIN 100.000 0.875 1.13846 UPK1B - Uroplakin-1b - Bos taurus (Bovine) - UPK1B gene Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. Taurus_UMD|evm.model.AC_000158.1.315 O60513 B4GT4_HUMAN 83.871 0.985507 1.00291 B4GALT4 - Beta-1,4-galactosyltransferase 4 - Homo sapiens (Human) - B4GALT4 gene Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Taurus_UMD|evm.model.AC_000158.1.316 Q2M1Z3 RHG31_HUMAN 83.780 0.998623 1.00554 ARHGAP31 - Rho GTPase-activating protein 31 - Homo sapiens (Human) - ARHGAP31 gene Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. Taurus_UMD|evm.model.AC_000158.1.317 Q0VCF5 TM39A_BOVIN 100.000 0.99591 1.00205 TMEM39A - Transmembrane protein 39A - Bos taurus (Bovine) - TMEM39A gene Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools (By similarity). Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L (By similarity). Taurus_UMD|evm.model.AC_000158.1.318 Q5E9Q1 PGLT1_BOVIN 100.000 0.994911 1.00255 POGLUT1 - Protein O-glucosyltransferase 1 precursor - Bos taurus (Bovine) - POGLUT1 gene Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C. Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (By similarity). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (By similarity). Notch glucosylation does not affect Notch ligand binding (By similarity). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity). Taurus_UMD|evm.model.AC_000158.1.319 Q9NPL8 TIDC1_HUMAN 67.742 0.993569 1.09123 TIMMDC1 - Complex I assembly factor TIMMDC1, mitochondrial - Homo sapiens (Human) - TIMMDC1 gene Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I. Taurus_UMD|evm.model.AC_000158.1.320 P42070 CD80_RABIT 63.317 0.891892 0.742475 CD80 - T-lymphocyte activation antigen CD80 precursor - Oryctolagus cuniculus (Rabbit) - CD80 gene Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor. Taurus_UMD|evm.model.AC_000158.1.321 Q32KR8 ADPRH_BOVIN 100.000 0.99435 1.00283 ADPRH - [Protein ADP-ribosylarginine] hydrolase - Bos taurus (Bovine) - ADPRH gene Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins. Taurus_UMD|evm.model.AC_000158.1.322 Q5E9H0 PLA1A_BOVIN 100.000 0.924797 1.07895 PLA1A - Phospholipase A1 member A precursor - Bos taurus (Bovine) - PLA1A gene Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production. Taurus_UMD|evm.model.AC_000158.1.323 Q9HBU9 POPD2_HUMAN 81.481 0.948509 1.01374 POPDC2 - Popeye domain-containing protein 2 - Homo sapiens (Human) - POPDC2 gene Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Taurus_UMD|evm.model.AC_000158.1.324 Q6J3Q7 COX17_CANLF 84.615 0.5 1.20635 COX17 - Cytochrome c oxidase copper chaperone - Canis lupus familiaris (Dog) - COX17 gene Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). Taurus_UMD|evm.model.AC_000158.1.325 Q95LR0 CFA91_MACFA 79.400 0.997245 0.946545 CFAP91 - Cilia- and flagella-associated protein 91 - Macaca fascicularis (Crab-eating macaque) - CFAP91 gene May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity). May play a role in spermatogenesis (By similarity). Taurus_UMD|evm.model.AC_000158.1.326 Q8SQ01 NR1I2_MACMU 81.524 0.925054 1.07604 NR1I2 - Nuclear receptor subfamily 1 group I member 2 - Macaca mulatta (Rhesus macaque) - NR1I2 gene Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity). Taurus_UMD|evm.model.AC_000158.1.327 Q5YJC2 GSK3B_SPECI 88.028 0.88125 0.380952 GSK3B - Glycogen synthase kinase-3 beta - Spermophilus citellus (European suslik) - GSK3B gene Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity (By similarity). Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SFPQ upon T-cell activation. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2 (By similarity). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (By similarity). Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (By similarity). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity (By similarity). The complex composed, at least, of APC, CTNNB1 and GSK3B interacts with JPT1; the interaction requires the inactive form of GSK3B (phosphorylated at 'Ser-9') (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, leading to activate KAT5/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (By similarity). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Taurus_UMD|evm.model.AC_000158.1.328 P49841 GSK3B_HUMAN 98.381 0.828283 0.707143 GSK3B - Glycogen synthase kinase-3 beta - Homo sapiens (Human) - GSK3B gene Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2 (PubMed:19946213, PubMed:28903391). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (PubMed:19946213). Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed:28903391). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509). Regulates the circadian rhythmicity of hippocampal long-term potentiation and ARNTL/BMLA1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, leading to activate KAT5/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (PubMed:18846110). Taurus_UMD|evm.model.AC_000158.1.330 Q8NFN8 GP156_HUMAN 76.223 0.997253 0.894349 GPR156 - Probable G-protein coupled receptor 156 - Homo sapiens (Human) - GPR156 gene Orphan receptor. Taurus_UMD|evm.model.AC_000158.1.331 Q99879 H2B1M_HUMAN 92.523 0.854839 0.984127 H2BC14 - Histone H2B type 1-M - Homo sapiens (Human) - H2BC14 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000158.1.332 Q96CX6 LRC58_HUMAN 96.496 0.994624 1.0027 LRRC58 - Leucine-rich repeat-containing protein 58 - Homo sapiens (Human) - LRRC58 gene Taurus_UMD|evm.model.AC_000158.1.333 A4QPC6 BT2A2_MOUSE 31.405 0.462745 0.496109 Btn2a2 - Butyrophilin subfamily 2 member A2 precursor - Mus musculus (Mouse) - Btn2a2 gene Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. Taurus_UMD|evm.model.AC_000158.1.334 Q58D84 FSTL1_BOVIN 100.000 0.993506 1.00326 FSTL1 - Follistatin-related protein 1 precursor - Bos taurus (Bovine) - FSTL1 gene Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (By similarity). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (By similarity). Taurus_UMD|evm.model.AC_000158.1.335 P48305 NDUB4_BOVIN 99.225 0.984615 1.00775 NDUFB4 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 - Bos taurus (Bovine) - NDUFB4 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000158.1.336 Q93099 HGD_HUMAN 89.140 0.630075 1.49438 HGD - Homogentisate 1,2-dioxygenase - Homo sapiens (Human) - HGD gene cytoplasm, cytosol, extracellular exosome, homogentisate 1,2-dioxygenase activity, identical protein binding, L-phenylalanine catabolic process, tyrosine catabolic process Taurus_UMD|evm.model.AC_000158.1.337 A6QLI8 T2EA_BOVIN 100.000 0.719064 0.682648 GTF2E1 - General transcription factor IIE subunit 1 - Bos taurus (Bovine) - GTF2E1 gene Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). Taurus_UMD|evm.model.AC_000158.1.338 A6QLI8 T2EA_BOVIN 96.875 0.746479 0.486301 GTF2E1 - General transcription factor IIE subunit 1 - Bos taurus (Bovine) - GTF2E1 gene Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). Taurus_UMD|evm.model.AC_000158.1.339 Q9Y2K9 STB5L_HUMAN 90.978 0.998219 0.94688 STXBP5L - Syntaxin-binding protein 5-like - Homo sapiens (Human) - STXBP5L gene Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Plays also a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth (PubMed:25504045). Taurus_UMD|evm.model.AC_000158.1.340 O75417 DPOLQ_HUMAN 79.631 0.999229 1.00154 POLQ - DNA polymerase theta - Homo sapiens (Human) - POLQ gene DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA (PubMed:25642963, PubMed:25643323). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323). POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963). POLQ-mediated MMEJ may be required to promote the survival of cells with a compromised HR repair pathway, thereby preventing genomic havoc by resolving unrepaired lesions (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs. It then extends each strand from the base-paired region using the opposing overhang as a template. Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323). The polymerase activity is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084, PubMed:21050863, PubMed:22135286). Also exhibits low-fidelity DNA synthesis, translesion synthesis and lyase activity, and it is implicated in interstrand-cross-link repair, base excision repair and DNA end-joining (PubMed:14576298, PubMed:18503084, PubMed:19188258, PubMed:24648516). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity). Taurus_UMD|evm.model.AC_000158.1.341 A6NJG6 ARGFX_HUMAN 60.177 0.84375 0.406349 ARGFX - Arginine-fifty homeobox - Homo sapiens (Human) - ARGFX gene Putative transcription factor. Taurus_UMD|evm.model.AC_000158.1.342 Q9UH90 FBX40_HUMAN 87.395 0.994406 1.00846 FBXO40 - F-box only protein 40 - Homo sapiens (Human) - FBXO40 gene Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis. Taurus_UMD|evm.model.AC_000158.1.343 P14317 HCLS1_HUMAN 86.327 0.995885 1 HCLS1 - Hematopoietic lineage cell-specific protein - Homo sapiens (Human) - HCLS1 gene Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. Taurus_UMD|evm.model.AC_000158.1.344 Q14789 GOGB1_HUMAN 84.550 0.988221 1.01596 GOLGB1 - Golgin subfamily B member 1 - Homo sapiens (Human) - GOLGB1 gene May participate in forming intercisternal cross-bridges of the Golgi complex. Taurus_UMD|evm.model.AC_000158.1.345 Q8BP00 IQCB1_MOUSE 87.124 0.996661 1.00167 Iqcb1 - IQ calmodulin-binding motif-containing protein 1 - Mus musculus (Mouse) - Iqcb1 gene Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (By similarity). Taurus_UMD|evm.model.AC_000158.1.346 Q96CJ1 EAF2_HUMAN 87.072 0.992395 1.01154 EAF2 - ELL-associated factor 2 - Homo sapiens (Human) - EAF2 gene Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo. Taurus_UMD|evm.model.AC_000158.1.347 Q16348 S15A2_HUMAN 87.654 0.99726 1.00137 SLC15A2 - Solute carrier family 15 member 2 - Homo sapiens (Human) - SLC15A2 gene Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7756356, PubMed:18367661). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Probably acts by mediating transport of bacterial peptidoglycans across the plasma membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity). Taurus_UMD|evm.model.AC_000158.1.348 Q16348 S15A2_HUMAN 61.304 0.95045 0.91358 SLC15A2 - Solute carrier family 15 member 2 - Homo sapiens (Human) - SLC15A2 gene Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7756356, PubMed:18367661). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Probably acts by mediating transport of bacterial peptidoglycans across the plasma membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity). Taurus_UMD|evm.model.AC_000158.1.349 Q5R8C7 ILDR1_PONAB 83.759 0.990926 1.00916 ILDR1 - Immunoglobulin-like domain-containing receptor 1 precursor - Pongo abelii (Sumatran orangutan) - ILDR1 gene Putative membrane receptor. Taurus_UMD|evm.model.AC_000158.1.350 P42081 CD86_HUMAN 55.752 0.988201 1.0304 CD86 - T-lymphocyte activation antigen CD86 precursor - Homo sapiens (Human) - CD86 gene Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). Taurus_UMD|evm.model.AC_000158.1.351 P19525 E2AK2_HUMAN 67.500 0.957576 0.299456 EIF2AK2 - Interferon-induced, double-stranded RNA-activated protein kinase - Homo sapiens (Human) - EIF2AK2 gene IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19507191, PubMed:19189853, PubMed:21123651, PubMed:21072047, PubMed:22948139, PubMed:23229543, PubMed:22381929). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:20171114, PubMed:19840259, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:22214662, PubMed:19229320). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). Taurus_UMD|evm.model.AC_000158.1.352 P35384 CASR_BOVIN 99.908 0.998158 1.00092 CASR - Extracellular calcium-sensing receptor precursor - Bos taurus (Bovine) - CASR gene G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:8255296). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8255296). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (By similarity). Taurus_UMD|evm.model.AC_000158.1.353 Q9D8T7 SLIRP_MOUSE 67.532 0.730769 0.928571 Slirp - SRA stem-loop-interacting RNA-binding protein, mitochondrial precursor - Mus musculus (Mouse) - Slirp gene RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation (By similarity). Taurus_UMD|evm.model.AC_000158.1.354 P80416 CYTA_BOVIN 97.959 0.979798 1.0102 CSTA - Cystatin-A - Bos taurus (Bovine) - CSTA gene This is an intracellular thiol proteinase inhibitor. Taurus_UMD|evm.model.AC_000158.1.355 A4FUI1 MIX23_BOVIN 100.000 0.98374 0.854167 MIX23 - Protein MIX23 - Bos taurus (Bovine) - MIX23 gene Taurus_UMD|evm.model.AC_000158.1.356 Q2NKR7 F162A_BOVIN 100.000 0.837209 1.10256 FAM162A - Protein FAM162A - Bos taurus (Bovine) - FAM162A gene Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly. Taurus_UMD|evm.model.AC_000158.1.357 Q86VZ2 WDR5B_HUMAN 91.212 0.993958 1.00303 WDR5B - WD repeat-containing protein 5B - Homo sapiens (Human) - WDR5B gene May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex. Taurus_UMD|evm.model.AC_000158.1.358 A2VE08 IMA5_BOVIN 100.000 0.996289 1.00186 KPNA1 - Importin subunit alpha-5 - Bos taurus (Bovine) - KPNA1 gene Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Taurus_UMD|evm.model.AC_000158.1.359 Q8IXQ6 PARP9_HUMAN 64.699 0.997661 1.00117 PARP9 - Protein mono-ADP-ribosyltransferase PARP9 - Homo sapiens (Human) - PARP9 gene ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:16809771, PubMed:23230272, PubMed:26479788, PubMed:27796300). Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (PubMed:28525742). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (PubMed:28525742). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (PubMed:23230272). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272, PubMed:28525742). In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ); the complex function is negatively modulated by PARP9 activity (PubMed:28525742). Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (By similarity). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). Also suppresses PARP14-mediated STAT6 ADP-ribosylation (PubMed:27796300). Taurus_UMD|evm.model.AC_000158.1.360 Q8TDB6 DTX3L_HUMAN 64.075 0.997297 1 DTX3L - E3 ubiquitin-protein ligase DTX3L - Homo sapiens (Human) - DTX3L gene E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteosomal-mediated degradation (PubMed:26479788). Taurus_UMD|evm.model.AC_000158.1.361 Q460N5 PAR14_HUMAN 70.533 0.997222 0.999445 PARP14 - Protein mono-ADP-ribosyltransferase PARP14 - Homo sapiens (Human) - PARP14 gene ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:16061477, PubMed:27796300, PubMed:18851833, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300). Taurus_UMD|evm.model.AC_000158.1.362 Q58CU3 HBAP1_BOVIN 100.000 0.995876 1.00207 HSPBAP1 - HSPB1-associated protein 1 - Bos taurus (Bovine) - HSPBAP1 gene May play a role in cellular stress response. Taurus_UMD|evm.model.AC_000158.1.363 Q8BFQ6 DIRC2_MOUSE 80.544 0.995238 0.878661 Slc49a4 - Solute carrier family 49 member 4 - Mus musculus (Mouse) - Slc49a4 gene Electrogenic metabolite transporter. Taurus_UMD|evm.model.AC_000158.1.364 Q9P283 SEM5B_HUMAN 93.962 0.99816 0.944396 SEMA5B - Semaphorin-5B - Homo sapiens (Human) - SEMA5B gene May act as positive axonal guidance cues. Taurus_UMD|evm.model.AC_000158.1.365 Q2KIL5 PDIA5_BOVIN 100.000 0.996169 1.00192 PDIA5 - Protein disulfide-isomerase A5 precursor - Bos taurus (Bovine) - PDIA5 gene Taurus_UMD|evm.model.AC_000158.1.366 Q8BH47 SC22A_MOUSE 96.522 0.644068 0.576547 Sec22a - Vesicle-trafficking protein SEC22a - Mus musculus (Mouse) - Sec22a gene May be involved in vesicle transport between the ER and the Golgi complex. Taurus_UMD|evm.model.AC_000158.1.367 O95622 ADCY5_HUMAN 94.295 0.998411 0.998414 ADCY5 - Adenylate cyclase type 5 - Homo sapiens (Human) - ADCY5 gene Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). Taurus_UMD|evm.model.AC_000158.1.368 Q2KIP8 HACD2_BOVIN 99.213 0.992157 1.00394 HACD2 - Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 - Bos taurus (Bovine) - HACD2 gene Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation. Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Taurus_UMD|evm.model.AC_000158.1.369 P70081 H48_CHICK 97.590 0.645669 1.23301 H4-VIII - Histone H4 type VIII - Gallus gallus (Chicken) - H4-VIII gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000158.1.370 P79280 MYLK_PIG 95.745 0.0596506 16.8849 MYLK - Myosin light chain kinase, smooth muscle - Sus scrofa (Pig) - MYLK gene Phosphorylates a specific serine in the N-terminus of a myosin light chain. Also regulates actin-myosin interaction through a non-kinase activity (By similarity). Taurus_UMD|evm.model.AC_000158.1.371 Q49A88 CCD14_HUMAN 73.822 0.997877 0.988458 CCDC14 - Coiled-coil domain-containing protein 14 - Homo sapiens (Human) - CCDC14 gene Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization. Taurus_UMD|evm.model.AC_000158.1.372 Q3T064 ROP1_BOVIN 99.528 0.99061 1.00472 ROPN1 - Ropporin-1 - Bos taurus (Bovine) - ROPN1 gene Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. Taurus_UMD|evm.model.AC_000158.1.373 A2CG49 KALRN_MOUSE 97.990 0.980797 0.474359 Kalrn - Kalirin - Mus musculus (Mouse) - Kalrn gene Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity). Taurus_UMD|evm.model.AC_000158.1.374 O60229 KALRN_HUMAN 95.330 0.994638 0.374749 KALRN - Kalirin - Homo sapiens (Human) - KALRN gene Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Taurus_UMD|evm.model.AC_000158.1.375 P31754 UMPS_BOVIN 99.792 0.995842 1.00208 UMPS - Uridine 5'-monophosphate synthase - Bos taurus (Bovine) - UMPS gene Taurus_UMD|evm.model.AC_000158.1.376 P80747 ITB5_BOVIN 98.942 0.966709 0.97625 ITGB5 - Integrin beta-5 precursor - Bos taurus (Bovine) - ITGB5 gene Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. Taurus_UMD|evm.model.AC_000158.1.377 P97881 MUC13_RAT 53.235 0.546053 1.11152 Muc13 - Mucin-13 precursor - Rattus norvegicus (Rat) - Muc13 gene Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling. Taurus_UMD|evm.model.AC_000158.1.378 Q9ULI3 HEG1_HUMAN 69.839 0.580163 1.06589 HEG1 - Protein HEG homolog 1 precursor - Homo sapiens (Human) - HEG1 gene Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions. Taurus_UMD|evm.model.AC_000158.1.379 A0AV02 S12A8_HUMAN 80.138 0.996429 0.784314 SLC12A8 - Solute carrier family 12 member 8 - Homo sapiens (Human) - SLC12A8 gene Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. Taurus_UMD|evm.model.AC_000158.1.380 A0AV02 S12A8_HUMAN 90.000 0.796296 0.226891 SLC12A8 - Solute carrier family 12 member 8 - Homo sapiens (Human) - SLC12A8 gene Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. Taurus_UMD|evm.model.AC_000158.1.381 Q3Y4E1 ZN148_BOVIN 99.874 0.997484 1.00126 ZNF148 - Zinc finger protein 148 - Bos taurus (Bovine) - ZNF148 gene Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes (By similarity). Taurus_UMD|evm.model.AC_000158.1.382 A1A4L0 SNX4_BOVIN 100.000 0.900415 1.07111 SNX4 - Sorting nexin-4 - Bos taurus (Bovine) - SNX4 gene Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Taurus_UMD|evm.model.AC_000158.1.383 Q9BXB4 OSB11_HUMAN 94.149 0.98946 1.01606 OSBPL11 - Oxysterol-binding protein-related protein 11 - Homo sapiens (Human) - OSBPL11 gene Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Taurus_UMD|evm.model.AC_000158.1.384 Q9R0Q3 TMED2_MOUSE 93.956 0.89604 1.00498 Tmed2 - Transmembrane emp24 domain-containing protein 2 precursor - Mus musculus (Mouse) - Tmed2 gene Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing (By similarity). Required for morphogenesis of embryo and placenta. Taurus_UMD|evm.model.AC_000158.1.385 Q8BMN4 LMLN_MOUSE 89.474 0.942685 0.973568 Lmln - Leishmanolysin-like peptidase - Mus musculus (Mouse) - Lmln gene Metalloprotease. Taurus_UMD|evm.model.AC_000158.1.386 Q56JY1 RL35A_BOVIN 100.000 0.981982 1.00909 RPL35A - 60S ribosomal protein L35a - Bos taurus (Bovine) - RPL35A gene Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation (By similarity). The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site (By similarity). Taurus_UMD|evm.model.AC_000158.1.387 Q2T9V2 DRC9_BOVIN 99.771 0.995434 1.00229 IQCG - Dynein regulatory complex protein 9 - Bos taurus (Bovine) - IQCG gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility. Taurus_UMD|evm.model.AC_000158.1.388 Q96II8 LRCH3_HUMAN 90.222 0.98062 0.996139 LRCH3 - DISP complex protein LRCH3 - Homo sapiens (Human) - LRCH3 gene As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Taurus_UMD|evm.model.AC_000158.1.389 Q17QU6 UIF_BOVIN 100.000 0.99373 1.00314 FYTTD1 - UAP56-interacting factor - Bos taurus (Bovine) - FYTTD1 gene Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4 (By similarity). Taurus_UMD|evm.model.AC_000158.1.391 Q92622 RUBIC_HUMAN 90.103 0.979737 1.01543 RUBCN - Run domain Beclin-1-interacting and cysteine-rich domain-containing protein - Homo sapiens (Human) - RUBCN gene Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). Taurus_UMD|evm.model.AC_000158.1.392 Q8N307 MUC20_HUMAN 50.000 0.160284 0.994358 MUC20 - Mucin-20 precursor - Homo sapiens (Human) - MUC20 gene May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression. Taurus_UMD|evm.model.AC_000158.1.393 Q99102 MUC4_HUMAN 66.126 0.989603 0.487782 MUC4 - Mucin-4 precursor - Homo sapiens (Human) - MUC4 gene May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Taurus_UMD|evm.model.AC_000158.1.394 O02751 CFDP2_BOVIN 72.285 0.885522 0.501689 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000158.1.395 Q17R13 ACK1_BOVIN 99.904 0.968284 1.03176 TNK2 - Activated CDC42 kinase 1 - Bos taurus (Bovine) - TNK2 gene Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR (By similarity). Taurus_UMD|evm.model.AC_000158.1.396 Q8HZV3 TFR1_PIG 78.581 0.997155 0.915365 TFRC - Transferrin receptor protein 1 - Sus scrofa (Pig) - TFRC gene Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity). Taurus_UMD|evm.model.AC_000158.1.398 Q8WVZ1 ZDH19_HUMAN 84.333 0.776623 1.24595 ZDHHC19 - Palmitoyltransferase ZDHHC19 - Homo sapiens (Human) - ZDHHC19 gene Palmitoyltransferase that mediates palmitoylation of RRAS, leading to increased cell viability. Taurus_UMD|evm.model.AC_000158.1.399 Q3T124 OSTA_BOVIN 100.000 0.994135 1.00294 SLC51A - Organic solute transporter subunit alpha - Bos taurus (Bovine) - SLC51A gene Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids (By similarity). Taurus_UMD|evm.model.AC_000158.1.400 P49585 PCY1A_HUMAN 96.458 0.994565 1.00272 PCYT1A - Choline-phosphate cytidylyltransferase A - Homo sapiens (Human) - PCYT1A gene Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. Taurus_UMD|evm.model.AC_000158.1.401 Q32P71 DYT2B_BOVIN 79.581 0.519126 2.40789 DYNLT2B - Dynein light chain Tctex-type protein 2B - Bos taurus (Bovine) - DYNLT2B gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. Required for proper retrograde ciliary transport. Taurus_UMD|evm.model.AC_000158.1.402 Q96DZ7 T4S19_HUMAN 84.158 0.990148 0.971292 TM4SF19 - Transmembrane 4 L6 family member 19 - Homo sapiens (Human) - TM4SF19 gene integral component of membrane Taurus_UMD|evm.model.AC_000158.1.403 Q5REY7 UBXN7_PONAB 97.751 0.995918 1.00204 UBXN7 - UBX domain-containing protein 7 - Pongo abelii (Sumatran orangutan) - UBXN7 gene Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates (By similarity). Taurus_UMD|evm.model.AC_000158.1.404 Q99LW0 ANR10_MOUSE 93.103 0.320225 0.428916 Ankrd10 - Ankyrin repeat domain-containing protein 10 - Mus musculus (Mouse) - Ankrd10 gene Taurus_UMD|evm.model.AC_000158.1.405 Q0IIM1 RN168_BOVIN 99.825 0.996516 1.00175 RNF168 - E3 ubiquitin-protein ligase RNF168 - Bos taurus (Bovine) - RNF168 gene E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). Taurus_UMD|evm.model.AC_000158.1.406 Q147U7 SMCO1_HUMAN 80.841 0.990698 1.00467 SMCO1 - Single-pass membrane and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - SMCO1 gene Taurus_UMD|evm.model.AC_000158.1.407 Q32KQ2 WDR53_BOVIN 100.000 0.867314 0.863128 WDR53 - WD repeat-containing protein 53 - Bos taurus (Bovine) - WDR53 gene Taurus_UMD|evm.model.AC_000158.1.408 P0CH38 FBSP1_RAT 97.403 0.815603 1.22609 Fbxo45 - F-box/SPRY domain-containing protein 1 - Rattus norvegicus (Rat) - Fbxo45 gene Component of E3 ubiquitin ligase complexes (By similarity). Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons. May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation (By similarity). Taurus_UMD|evm.model.AC_000158.1.409 Q3ZBI5 LRC33_BOVIN 100.000 0.967504 0.978324 NRROS - Transforming growth factor beta activator LRRC33 precursor - Bos taurus (Bovine) - NRROS gene Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling. Taurus_UMD|evm.model.AC_000158.1.410 A6H7C9 CEP19_BOVIN 100.000 0.987805 1.00613 CEP19 - Centrosomal protein of 19 kDa - Bos taurus (Bovine) - CEP19 gene Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes. Taurus_UMD|evm.model.AC_000158.1.411 Q8TBF5 PIGX_HUMAN 70.612 0.655914 1.44186 PIGX - Phosphatidylinositol-glycan biosynthesis class X protein precursor - Homo sapiens (Human) - PIGX gene Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity). Taurus_UMD|evm.model.AC_000158.1.412 O46415 FRIL_BOVIN 92.571 0.988636 1.00571 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000158.1.413 Q64303 PAK2_RAT 91.794 0.995902 0.931298 Pak2 - Serine/threonine-protein kinase PAK 2 - Rattus norvegicus (Rat) - Pak2 gene Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (By similarity). Taurus_UMD|evm.model.AC_000158.1.415 Q96HI0 SENP5_HUMAN 89.007 0.997351 1 SENP5 - Sentrin-specific protease 5 - Homo sapiens (Human) - SENP5 gene Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. Taurus_UMD|evm.model.AC_000158.1.416 P52298 NCBP2_HUMAN 100.000 0.987261 1.00641 NCBP2 - Nuclear cap-binding protein subunit 2 - Homo sapiens (Human) - NCBP2 gene Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (PubMed:26382858). Taurus_UMD|evm.model.AC_000158.1.417 Q69YL0 NCAS2_HUMAN 85.714 0.97 1.0101 NCBP2AS2 - Protein NCBP2AS2 - Homo sapiens (Human) - NCBP2AS2 gene Taurus_UMD|evm.model.AC_000158.1.418 Q86VD9 PIGZ_HUMAN 76.616 0.760417 1.16062 PIGZ - GPI mannosyltransferase 4 - Homo sapiens (Human) - PIGZ gene Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues. Taurus_UMD|evm.model.AC_000158.1.419 P08582 TRFM_HUMAN 90.999 0.959459 1.00271 MELTF - Melanotransferrin precursor - Homo sapiens (Human) - MELTF gene Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. Taurus_UMD|evm.model.AC_000158.1.420 Q28C55 DLG1_XENTR 83.673 0.440986 0.831715 dlg1 - Disks large homolog 1 - Xenopus tropicalis (Western clawed frog) - dlg1 gene Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction and cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000158.1.421 Q3SYR7 RL9_BOVIN 97.396 0.989583 1 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000158.1.422 Q02337 BDH_BOVIN 100.000 0.824519 1.2093 BDH1 - D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - BDH1 gene matrix side of mitochondrial inner membrane, 3-hydroxybutyrate dehydrogenase activity Taurus_UMD|evm.model.AC_000158.1.423 Q32KY0 APOD_BOVIN 99.471 0.882629 1.12698 APOD - Apolipoprotein D precursor - Bos taurus (Bovine) - APOD gene APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts (By similarity). Taurus_UMD|evm.model.AC_000158.1.424 Q3SZX2 IPP2_BOVIN 99.034 0.990385 1.00483 PPP1R2 - Protein phosphatase inhibitor 2 - Bos taurus (Bovine) - PPP1R2 gene Inhibitor of protein-phosphatase 1. Taurus_UMD|evm.model.AC_000158.1.425 Q4R8C7 AIDA_MACFA 96.000 0.541436 0.658182 AIDA - Axin interactor, dorsalization-associated protein - Macaca fascicularis (Crab-eating macaque) - AIDA gene Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). Taurus_UMD|evm.model.AC_000158.1.426 Q15057 ACAP2_HUMAN 97.686 0.997433 1.00129 ACAP2 - Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 - Homo sapiens (Human) - ACAP2 gene GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Taurus_UMD|evm.model.AC_000158.1.427 Q8NBI6 XXLT1_HUMAN 98.246 0.189831 0.750636 XXYLT1 - Xyloside xylosyltransferase 1 - Homo sapiens (Human) - XXYLT1 gene Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869). Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869). Taurus_UMD|evm.model.AC_000158.1.429 Q5EBM0 CMPK2_HUMAN 66.667 0.602564 0.173719 CMPK2 - UMP-CMP kinase 2, mitochondrial precursor - Homo sapiens (Human) - CMPK2 gene May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. Taurus_UMD|evm.model.AC_000158.1.430 Q8N2R8 FA43A_HUMAN 93.381 0.995283 1.00236 FAM43A - Protein FAM43A - Homo sapiens (Human) - FAM43A gene Taurus_UMD|evm.model.AC_000158.1.432 Q2YDM7 LSG1_BOVIN 98.338 0.996983 1.01687 LSG1 - Large subunit GTPase 1 homolog - Bos taurus (Bovine) - LSG1 gene GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity). Taurus_UMD|evm.model.AC_000158.1.433 Q2T9K0 TMM44_HUMAN 69.106 0.986667 0.947368 TMEM44 - Transmembrane protein 44 - Homo sapiens (Human) - TMEM44 gene Taurus_UMD|evm.model.AC_000158.1.434 Q95JN5 AT133_MACFA 90.244 0.378566 2.63618 ATP13A3 - Polyamine-transporting ATPase 13A3 - Macaca fascicularis (Crab-eating macaque) - ATP13A3 gene ATP-driven pump involved in endocytosis-dependent polyamine transport. Uses ATP as an energy source to transfer polyamine precursor putrescine from the endosomal compartment to the cytosol. Taurus_UMD|evm.model.AC_000158.1.435 P40197 GPV_HUMAN 72.842 0.975926 0.964286 GP5 - Platelet glycoprotein V precursor - Homo sapiens (Human) - GP5 gene The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. Taurus_UMD|evm.model.AC_000158.1.436 Q8TF66 LRC15_HUMAN 86.403 0.991453 1.00688 LRRC15 - Leucine-rich repeat-containing protein 15 precursor - Homo sapiens (Human) - LRRC15 gene extracellular exosome, extracellular matrix, extracellular space, collagen binding, fibronectin binding, laminin binding, negative regulation of protein localization to plasma membrane, positive regulation of cell migration, receptor-mediated virion attachment to host cell Taurus_UMD|evm.model.AC_000158.1.437 P22792 CPN2_HUMAN 75.912 0.996357 1.00734 CPN2 - Carboxypeptidase N subunit 2 precursor - Homo sapiens (Human) - CPN2 gene The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit. Taurus_UMD|evm.model.AC_000158.1.439 Q3ZBG4 HES1_BOVIN 100.000 0.992883 1.00357 HES1 - Transcription factor HES-1 - Bos taurus (Bovine) - HES1 gene Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). Taurus_UMD|evm.model.AC_000158.1.440 O60313 OPA1_HUMAN 92.118 0.998031 1.05833 OPA1 - Dynamin-like 120 kDa protein, mitochondrial precursor - Homo sapiens (Human) - OPA1 gene Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28746876). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (PubMed:17709429). Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:20185555). The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (PubMed:20185555). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance (PubMed:20974897, PubMed:18158317). Taurus_UMD|evm.model.AC_000158.1.441 Q4VNC1 AT134_HUMAN 89.112 0.995826 1.00167 ATP13A4 - Probable cation-transporting ATPase 13A4 - Homo sapiens (Human) - ATP13A4 gene plasma membrane, cellular calcium ion homeostasis, ion transmembrane transport Taurus_UMD|evm.model.AC_000158.1.442 Q3TYU2 AT135_MOUSE 76.536 0.577922 0.253289 Atp13a5 - Probable cation-transporting ATPase 13A5 - Mus musculus (Mouse) - Atp13a5 gene cellular calcium ion homeostasis Taurus_UMD|evm.model.AC_000158.1.443 Q4VNC0 AT135_HUMAN 86.519 0.929085 0.798851 ATP13A5 - Probable cation-transporting ATPase 13A5 - Homo sapiens (Human) - ATP13A5 gene plasma membrane, cellular calcium ion homeostasis, ion transmembrane transport Taurus_UMD|evm.model.AC_000158.1.445 Q9HDD0 PLAT1_HUMAN 85.207 0.879581 1.1369 PLAAT1 - Phospholipase A and acyltransferase 1 - Homo sapiens (Human) - PLAAT1 gene Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:21880860, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:21880860, PubMed:22825852, PubMed:27623847). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:21880860). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE) which serves as precursor for N-acylethanolamines (NAEs) (PubMed:21880860, PubMed:22825852, PubMed:27623847). Taurus_UMD|evm.model.AC_000158.1.447 Q8IYB1 M21D2_HUMAN 99.796 0.995935 1.00204 MB21D2 - Protein MB21D2 - Homo sapiens (Human) - MB21D2 gene cadherin binding, protein-containing complex binding Taurus_UMD|evm.model.AC_000158.1.448 P61150 FGF12_RAT 100.000 0.991803 1.00412 Fgf12 - Fibroblast growth factor 12 - Rattus norvegicus (Rat) - Fgf12 gene Involved in nervous system development and function. Promote neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. Taurus_UMD|evm.model.AC_000158.1.449 Q8CBY0 GATC_MOUSE 38.333 0.567308 0.670968 Gatc - Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial precursor - Mus musculus (Mouse) - Gatc gene Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Taurus_UMD|evm.model.AC_000158.1.450 Q8IVM0 CCD50_HUMAN 85.465 0.354772 1.57516 CCDC50 - Coiled-coil domain-containing protein 50 - Homo sapiens (Human) - CCDC50 gene Involved in EGFR signaling. Taurus_UMD|evm.model.AC_000158.1.451 Q99877 H2B1N_HUMAN 94.737 0.520833 1.14286 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000158.1.452 A6NCL1 GEMC1_HUMAN 87.126 0.994012 1 GMNC - Geminin coiled-coil domain-containing protein 1 - Homo sapiens (Human) - GMNC gene Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity). Taurus_UMD|evm.model.AC_000158.1.453 P68105 EF1A1_RABIT 99.618 0.992395 0.569264 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000158.1.454 A2Q0Z0 EF1A1_HORSE 100.000 0.988024 0.361472 EEF1A1 - Elongation factor 1-alpha 1 - Equus caballus (Horse) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000158.1.455 P62752 RL23A_RAT 100.000 0.916031 0.839744 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000158.1.456 Q9NPH3 IL1AP_HUMAN 76.720 0.819242 1.20351 IL1RAP - Interleukin-1 receptor accessory protein precursor - Homo sapiens (Human) - IL1RAP gene Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). Taurus_UMD|evm.model.AC_000158.1.457 Q6UWW9 TM207_HUMAN 68.794 0.913333 1.0274 TMEM207 - Transmembrane protein 207 precursor - Homo sapiens (Human) - TMEM207 gene Taurus_UMD|evm.model.AC_000158.1.458 Q9XT98 CLD16_BOVIN 100.000 0.720798 1.38189 CLDN16 - Claudin-16 - Bos taurus (Bovine) - CLDN16 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (By similarity). Taurus_UMD|evm.model.AC_000158.1.459 Q6L708 CLD1_BOVIN 96.209 0.990291 0.976303 CLDN1 - Claudin-1 - Bos taurus (Bovine) - CLDN1 gene Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (By similarity). Taurus_UMD|evm.model.AC_000158.1.460 Q8IVL5 P3H2_HUMAN 92.655 0.997171 0.998588 P3H2 - Prolyl 3-hydroxylase 2 precursor - Homo sapiens (Human) - P3H2 gene Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (PubMed:18487197). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1 (PubMed:18487197). Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline (PubMed:18487197). Has no activity on substrates that lack 4-hydroxyproline in the third position (PubMed:18487197). Taurus_UMD|evm.model.AC_000158.1.461 O88898 P63_MOUSE 98.908 0.996885 0.944118 Tp63 - Tumor protein 63 - Mus musculus (Mouse) - Tp63 gene Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Taurus_UMD|evm.model.AC_000158.1.463 Q6ZUI0 TPRG1_HUMAN 85.000 0.992883 1.02182 TPRG1 - Tumor protein p63-regulated gene 1 protein - Homo sapiens (Human) - TPRG1 gene cytoplasm Taurus_UMD|evm.model.AC_000158.1.464 Q93052 LPP_HUMAN 89.639 0.888412 0.761438 LPP - Lipoma-preferred partner - Homo sapiens (Human) - LPP gene May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. Taurus_UMD|evm.model.AC_000158.1.466 P41182 BCL6_HUMAN 95.184 0.997171 1.00142 BCL6 - B-cell lymphoma 6 protein - Homo sapiens (Human) - BCL6 gene Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. Taurus_UMD|evm.model.AC_000158.1.467 Q5QGT7 RTP2_HUMAN 90.667 0.991071 0.995556 RTP2 - Receptor-transporting protein 2 - Homo sapiens (Human) - RTP2 gene Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs. Taurus_UMD|evm.model.AC_000158.1.468 O46688 SMS_SHEEP 99.138 0.982906 1.00862 SST - Somatostatin precursor - Ovis aries (Sheep) - SST gene Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. Taurus_UMD|evm.model.AC_000158.1.469 Q96DX8 RTP4_HUMAN 62.150 0.367491 2.30081 RTP4 - Receptor-transporting protein 4 - Homo sapiens (Human) - RTP4 gene Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity). Taurus_UMD|evm.model.AC_000158.1.470 P48740 MASP1_HUMAN 86.517 0.0959651 1.31187 MASP1 - Mannan-binding lectin serine protease 1 precursor - Homo sapiens (Human) - MASP1 gene Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed:21258343). Taurus_UMD|evm.model.AC_000158.1.471 Q95JK0 RTP1_MACFA 94.714 0.991228 0.86692 RTP1 - Receptor-transporting protein 1 - Macaca fascicularis (Crab-eating macaque) - RTP1 gene Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs. Taurus_UMD|evm.model.AC_000158.1.472 P15907 SIAT1_HUMAN 82.555 0.990148 1 ST6GAL1 - Beta-galactoside alpha-2,6-sialyltransferase 1 - Homo sapiens (Human) - ST6GAL1 gene Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. Taurus_UMD|evm.model.AC_000158.1.473 O95772 STR3N_HUMAN 92.340 0.991525 1.00855 STARD3NL - STARD3 N-terminal-like protein - Homo sapiens (Human) - STARD3NL gene Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263). Taurus_UMD|evm.model.AC_000158.1.474 Q3Y5Z3 ADIPO_BOVIN 100.000 0.908745 1.09583 ADIPOQ - Adiponectin precursor - Bos taurus (Bovine) - ADIPOQ gene Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW (By similarity). Taurus_UMD|evm.model.AC_000158.1.475 P35249 RFC4_HUMAN 95.604 0.994521 1.00551 RFC4 - Replication factor C subunit 4 - Homo sapiens (Human) - RFC4 gene The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template. Taurus_UMD|evm.model.AC_000158.1.476 Q5RKI1 IF4A2_RAT 100.000 0.995098 1.00246 Eif4a2 - Eukaryotic initiation factor 4A-II - Rattus norvegicus (Rat) - Eif4a2 gene ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). Taurus_UMD|evm.model.AC_000158.1.477 P01044 KNG1_BOVIN 99.517 0.996785 1.00161 KNG1 - Kininogen-1 precursor - Bos taurus (Bovine) - KNG1 gene (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. Taurus_UMD|evm.model.AC_000158.1.478 P33433 HRG_BOVIN 85.950 0.223464 1.35606 HRG - Histidine-rich glycoprotein - Bos taurus (Bovine) - HRG gene Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2 (By similarity). Taurus_UMD|evm.model.AC_000158.1.479 Q58D62 FETUB_BOVIN 100.000 0.994845 1.00258 FETUB - Fetuin-B precursor - Bos taurus (Bovine) - FETUB gene Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity). Taurus_UMD|evm.model.AC_000158.1.480 P12763 FETUA_BOVIN 100.000 0.994444 1.00279 AHSG - Alpha-2-HS-glycoprotein precursor - Bos taurus (Bovine) - AHSG gene Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone. Taurus_UMD|evm.model.AC_000158.1.481 Q3ZBA6 DJB11_BOVIN 100.000 0.994429 1.00279 DNAJB11 - DnaJ homolog subfamily B member 11 precursor - Bos taurus (Bovine) - DNAJB11 gene As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. Taurus_UMD|evm.model.AC_000158.1.482 A4IF93 TBCC1_BOVIN 99.820 0.996416 1.0018 TBCCD1 - TBCC domain-containing protein 1 - Bos taurus (Bovine) - TBCCD1 gene Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration. Taurus_UMD|evm.model.AC_000158.1.483 P06504 CRYGS_BOVIN 100.000 0.988827 1.00562 CRYGS - Gamma-crystallin S - Bos taurus (Bovine) - CRYGS gene Crystallins are the dominant structural components of the vertebrate eye lens. Taurus_UMD|evm.model.AC_000158.1.484 P08548 LIN1_NYCCO 32.143 0.301099 0.361111 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Taurus_UMD|evm.model.AC_000158.1.486 P49619 DGKG_HUMAN 90.526 0.979221 0.973451 DGKG - Diacylglycerol kinase gamma - Homo sapiens (Human) - DGKG gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity). Has no apparent specificity with regard to the acyl compositions of diacylglycerol (PubMed:8034597). Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity). Taurus_UMD|evm.model.AC_000158.1.487 P41161 ETV5_HUMAN 93.738 0.995951 0.968627 ETV5 - ETS translocation variant 5 - Homo sapiens (Human) - ETV5 gene Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'. Taurus_UMD|evm.model.AC_000158.1.488 Q0VCN1 NMRL1_BOVIN 46.847 0.932203 0.394649 NMRAL1 - NmrA-like family domain-containing protein 1 - Bos taurus (Bovine) - NMRAL1 gene Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer (By similarity). Taurus_UMD|evm.model.AC_000158.1.489 Q0VCN1 NMRL1_BOVIN 60.630 0.984375 0.428094 NMRAL1 - NmrA-like family domain-containing protein 1 - Bos taurus (Bovine) - NMRAL1 gene Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer (By similarity). Taurus_UMD|evm.model.AC_000158.1.490 P62997 TRA2B_RAT 100.000 0.99308 1.00347 Tra2b - Transformer-2 protein homolog beta - Rattus norvegicus (Rat) - Tra2b gene Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA (By similarity). Taurus_UMD|evm.model.AC_000158.1.491 Q9Y6M1 IF2B2_HUMAN 98.495 0.996661 1 IGF2BP2 - Insulin-like growth factor 2 mRNA-binding protein 2 - Homo sapiens (Human) - IGF2BP2 gene RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Taurus_UMD|evm.model.AC_000158.1.493 Q5R7K7 SENP2_PONAB 91.341 0.99661 1.0017 SENP2 - Sentrin-specific protease 2 - Pongo abelii (Sumatran orangutan) - SENP2 gene Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (By similarity). Taurus_UMD|evm.model.AC_000158.1.494 Q8WWY8 LIPH_HUMAN 86.253 0.982533 1.01552 LIPH - Lipase member H precursor - Homo sapiens (Human) - LIPH gene Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Taurus_UMD|evm.model.AC_000158.1.495 Q08D99 TM41A_BOVIN 100.000 0.992453 1.00379 TMEM41A - Transmembrane protein 41A precursor - Bos taurus (Bovine) - TMEM41A gene Taurus_UMD|evm.model.AC_000158.1.496 A7MBB4 M3K13_BOVIN 99.689 0.997932 1.00104 MAP3K13 - Mitogen-activated protein kinase kinase kinase 13 - Bos taurus (Bovine) - MAP3K13 gene Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity). Taurus_UMD|evm.model.AC_000158.1.497 Q08426 ECHP_HUMAN 82.988 0.997238 1.00138 EHHADH - Peroxisomal bifunctional enzyme - Homo sapiens (Human) - EHHADH gene Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. Catalyzes two of the four reactions of the long straight chain fatty acids peroxisomal beta-oxidation pathway. Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species (Probable). Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (By similarity). With HSD17B4, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity (PubMed:15060085). Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways (By similarity). Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation (PubMed:15060085). Taurus_UMD|evm.model.AC_000158.1.498 A7E369 CC070_BOVIN 100.000 0.992032 1.004 UPF0524 protein C3orf70 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000158.1.499 Q8N3P4 VPS8_HUMAN 94.342 0.997372 0.532913 VPS8 - Vacuolar protein sorting-associated protein 8 homolog - Homo sapiens (Human) - VPS8 gene Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290). Taurus_UMD|evm.model.AC_000158.1.500 Q9HAY2 MAGF1_HUMAN 82.639 0.831395 1.12052 MAGEF1 - Melanoma-associated antigen F1 - Homo sapiens (Human) - MAGEF1 gene Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair (PubMed:29225034). Taurus_UMD|evm.model.AC_000158.1.502 P54753 EPHB3_HUMAN 98.297 0.997996 1 EPHB3 - Ephrin type-B receptor 3 precursor - Homo sapiens (Human) - EPHB3 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. Taurus_UMD|evm.model.AC_000158.1.504 Q810U2 TDM1A_MOUSE 34.201 0.902027 0.970492 Teddm1a - Transmembrane epididymal protein 1A - Mus musculus (Mouse) - Teddm1a gene Taurus_UMD|evm.model.AC_000158.1.506 Q5EA53 T2FA_BOVIN 59.375 0.842857 0.135397 GTF2F1 - General transcription factor IIF subunit 1 - Bos taurus (Bovine) - GTF2F1 gene TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation (By similarity). Taurus_UMD|evm.model.AC_000158.1.507 Q8CHM9 TEDM1_RAT 36.310 0.724891 0.75082 Teddm1 - Transmembrane epididymal protein 1 - Rattus norvegicus (Rat) - Teddm1 gene Taurus_UMD|evm.model.AC_000158.1.508 Q9H2X0 CHRD_HUMAN 89.389 0.960334 1.00314 CHRD - Chordin precursor - Homo sapiens (Human) - CHRD gene Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity). Taurus_UMD|evm.model.AC_000158.1.510 P42706 TPO_PIG 92.308 0.0706215 13.6154 THPO - Thrombopoietin - Sus scrofa (Pig) - THPO gene Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Taurus_UMD|evm.model.AC_000158.1.511 Q923G2 RPAB3_MOUSE 100.000 0.986755 1.00667 Polr2h - DNA-directed RNA polymerases I, II, and III subunit RPABC3 - Mus musculus (Mouse) - Polr2h gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity). Taurus_UMD|evm.model.AC_000158.1.512 P51788 CLCN2_HUMAN 92.097 0.985915 1.02784 CLCN2 - Chloride channel protein 2 - Homo sapiens (Human) - CLCN2 gene Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (PubMed:29403011, PubMed:29403012). Taurus_UMD|evm.model.AC_000158.1.513 Q6UXB0 F131A_HUMAN 95.266 0.962857 0.956284 FAM131A - Protein FAM131A - Homo sapiens (Human) - FAM131A gene Taurus_UMD|evm.model.AC_000158.1.514 Q04637 IF4G1_HUMAN 92.994 0.998757 1.00625 EIF4G1 - Eukaryotic translation initiation factor 4 gamma 1 - Homo sapiens (Human) - EIF4G1 gene Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Taurus_UMD|evm.model.AC_000158.1.515 P56701 PSMD2_BOVIN 100.000 0.9978 1.0011 PSMD2 - 26S proteasome non-ATPase regulatory subunit 2 - Bos taurus (Bovine) - PSMD2 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Taurus_UMD|evm.model.AC_000158.1.516 F1N476 ECE2_BOVIN 100.000 0.822563 1.19346 ECE2 - Endothelin-converting enzyme 2 - Bos taurus (Bovine) - ECE2 gene Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides (By similarity). May play a role in amyloid-beta processing (By similarity). Taurus_UMD|evm.model.AC_000158.1.517 Q92685 ALG3_HUMAN 88.453 0.995652 1.05023 ALG3 - Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase - Homo sapiens (Human) - ALG3 gene Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol. Taurus_UMD|evm.model.AC_000158.1.518 Q8N398 VW5B2_HUMAN 87.410 0.998397 1.00483 VWA5B2 - von Willebrand factor A domain-containing protein 5B2 - Homo sapiens (Human) - VWA5B2 gene Taurus_UMD|evm.model.AC_000158.1.519 Q9NUQ8 ABCF3_HUMAN 98.307 0.997183 1.00141 ABCF3 - ATP-binding cassette sub-family F member 3 - Homo sapiens (Human) - ABCF3 gene Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B. Taurus_UMD|evm.model.AC_000158.1.520 P84092 AP2M1_RAT 99.540 0.995392 0.997701 Ap2m1 - AP-2 complex subunit mu - Rattus norvegicus (Rat) - Ap2m1 gene Component of the adaptor protein complex 2 (AP-2) (PubMed:14745134, PubMed:15473838). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways (PubMed:14745134, PubMed:15473838). Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation (PubMed:14745134, PubMed:15473838). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome (PubMed:14745134, PubMed:15473838). The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components (PubMed:14745134, PubMed:15473838). Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation (PubMed:14745134, PubMed:15473838). AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis (PubMed:14745134, PubMed:15473838). AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface (By similarity). AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules (PubMed:15985462). AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway (By similarity). During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 mu (AP2M1) subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs (PubMed:15985462). The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Thr-156 in membrane-associated AP-2 (PubMed:15985462, PubMed:11516654). The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role in endocytosis of frizzled family members upon Wnt signaling (PubMed:20947020). Taurus_UMD|evm.model.AC_000158.1.521 Q92997 DVL3_HUMAN 98.571 0.493644 1.97765 DVL3 - Segment polarity protein dishevelled homolog DVL-3 - Homo sapiens (Human) - DVL3 gene Involved in the signal transduction pathway mediated by multiple Wnt genes. Taurus_UMD|evm.model.AC_000158.1.522 A5X5Y0 5HT3E_HUMAN 69.956 0.995434 0.960526 HTR3E - 5-hydroxytryptamine receptor 3E precursor - Homo sapiens (Human) - HTR3E gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Taurus_UMD|evm.model.AC_000158.1.523 Q8WXA8 5HT3C_HUMAN 74.944 0.995536 1.00224 HTR3C - 5-hydroxytryptamine receptor 3C precursor - Homo sapiens (Human) - HTR3C gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Taurus_UMD|evm.model.AC_000158.1.525 O15440 MRP5_HUMAN 95.268 0.998609 1.0007 ABCC5 - Multidrug resistance-associated protein 5 - Homo sapiens (Human) - ABCC5 gene Acts as a multispecific organic anion pump which can transport nucleotide analogs. Heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). Taurus_UMD|evm.model.AC_000158.1.526 P20821 GCSH_BOVIN 94.203 0.985612 0.803468 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Taurus_UMD|evm.model.AC_000158.1.527 O54749 CP2J5_MOUSE 28.643 0.772549 0.508982 Cyp2j5 - Cytochrome P450 2J5 - Mus musculus (Mouse) - Cyp2j5 gene cytoplasm, intracellular membrane-bounded organelle, heme binding, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, steroid hydroxylase activity, angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure, exogenous drug catabolic process, organic acid metabolic process, positive regulation of estrogen secretion, regulation of systemic arterial blood pressure by hormone Taurus_UMD|evm.model.AC_000158.1.528 P62278 RS13_RAT 97.727 0.879195 0.986755 Rps13 - 40S ribosomal protein S13 - Rattus norvegicus (Rat) - Rps13 gene cytosolic small ribosomal subunit, nucleolus, nucleus, postsynaptic density, synapse, 5.8S rRNA binding, mRNA 5'-UTR binding, mRNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome Taurus_UMD|evm.model.AC_000158.1.529 Q8TAV3 CP2W1_HUMAN 53.571 0.482456 0.232653 CYP2W1 - Cytochrome P450 2W1 precursor - Homo sapiens (Human) - CYP2W1 gene A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism (PubMed:22591743, PubMed:26936974). Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retinal are potential endogenous substrates (PubMed:26936974). Catalyzes both epoxidation of double bonds and hydroxylation of carbon hydrogen bonds of the fatty acyl chain of 1-acylphospholipids/2-lysophospholipids. Can metabolize various lysophospholipids classes including lysophosphatidylcholines (LPCs), lysophosphatidylinositols (LPIs), lysophosphatidylserines (LPSs), lysophosphatidylglycerols (LPGs), lysophosphatidylethanolamines (LPEs) and lysophosphatidic acids (LPAs) (PubMed:22591743). Has low or no activity toward 2-acylphospholipids/1-lysophospholipids, diacylphospholipids and free fatty acids (PubMed:26936974, PubMed:22591743). May play a role in tumorigenesis by activating procarcinogens such as aflatoxin B1, polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:20805301, PubMed:16551781, PubMed:24278521). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:22591743, PubMed:26936974). Taurus_UMD|evm.model.AC_000158.1.530 Q2KHV4 PARL_BOVIN 100.000 0.994709 1.00265 PARL - Presenilins-associated rhomboid-like protein, mitochondrial precursor - Bos taurus (Bovine) - PARL gene Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). Taurus_UMD|evm.model.AC_000158.1.531 Q0P591 MA6D1_BOVIN 100.000 0.643192 1.10938 MAP6D1 - MAP6 domain-containing protein 1 - Bos taurus (Bovine) - MAP6D1 gene May have microtubule-stabilizing activity. Taurus_UMD|evm.model.AC_000158.1.532 Q9ULM3 YETS2_HUMAN 92.842 0.998585 0.993671 YEATS2 - YEATS domain-containing protein 2 - Homo sapiens (Human) - YEATS2 gene Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). Taurus_UMD|evm.model.AC_000158.1.533 Q5E995 RS6_BOVIN 96.787 0.992 1.00402 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Taurus_UMD|evm.model.AC_000158.1.534 Q6TFL4 KLH24_HUMAN 99.667 0.996672 1.00167 KLHL24 - Kelch-like protein 24 - Homo sapiens (Human) - KLHL24 gene Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (PubMed:27798626). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). Taurus_UMD|evm.model.AC_000158.1.536 Q8WZ60 KLHL6_HUMAN 96.769 0.996774 0.99839 KLHL6 - Kelch-like protein 6 - Homo sapiens (Human) - KLHL6 gene Involved in B-lymphocyte antigen receptor signaling and germinal center formation. Taurus_UMD|evm.model.AC_000158.1.537 Q5E9B1 LDHB_BOVIN 97.006 0.99403 1.00299 LDHB - L-lactate dehydrogenase B chain - Bos taurus (Bovine) - LDHB gene L-lactate dehydrogenase activity Taurus_UMD|evm.model.AC_000158.1.538 Q86YR7 MF2L2_HUMAN 77.665 0.981168 0.953321 MCF2L2 - Probable guanine nucleotide exchange factor MCF2L2 - Homo sapiens (Human) - MCF2L2 gene Probably functions as a guanine nucleotide exchange factor. Taurus_UMD|evm.model.AC_000158.1.539 Q9UQV4 LAMP3_HUMAN 66.585 0.94213 1.03846 LAMP3 - Lysosome-associated membrane glycoprotein 3 precursor - Homo sapiens (Human) - LAMP3 gene May play a role in dendritic cell function and in adaptive immunity. Taurus_UMD|evm.model.AC_000158.1.540 Q96RQ3 MCCA_HUMAN 88.414 0.997245 1.00138 MCCC1 - Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor - Homo sapiens (Human) - MCCC1 gene Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. Taurus_UMD|evm.model.AC_000158.1.541 Q96GG9 DCNL1_HUMAN 99.590 0.991837 0.945946 DCUN1D1 - DCN1-like protein 1 - Homo sapiens (Human) - DCUN1D1 gene Part of an E3 ubiquitin ligase complex for neddylation (PubMed:18826954). Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes (PubMed:26906416, PubMed:23201271, PubMed:19617556, PubMed:23401859). Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity). Taurus_UMD|evm.model.AC_000158.1.542 Q9Y2G3 AT11B_HUMAN 93.713 0.998302 1.00085 ATP11B - Phospholipid-transporting ATPase IF - Homo sapiens (Human) - ATP11B gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401). Taurus_UMD|evm.model.AC_000158.1.545 P54231 SOX2_SHEEP 100.000 0.993769 1.00313 SOX2 - Transcription factor SOX-2 - Ovis aries (Sheep) - SOX2 gene Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity). Taurus_UMD|evm.model.AC_000158.1.547 P02993 EF1A_ARTSA 44.218 0.983607 0.264069 Elongation factor 1-alpha - Artemia salina (Brine shrimp) Taurus_UMD|evm.model.AC_000158.1.548 A2Q0Z0 EF1A1_HORSE 64.286 0.43949 0.339827 EEF1A1 - Elongation factor 1-alpha 1 - Equus caballus (Horse) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000158.1.549 Q3ZBN8 TIM14_BOVIN 100.000 0.982906 1.00862 DNAJC19 - Mitochondrial import inner membrane translocase subunit TIM14 - Bos taurus (Bovine) - DNAJC19 gene Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). Taurus_UMD|evm.model.AC_000158.1.550 Q2TBT7 FXR1_BOVIN 99.813 0.987037 0.869565 FXR1 - Fragile X mental retardation syndrome-related protein 1 - Bos taurus (Bovine) - FXR1 gene RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity). Taurus_UMD|evm.model.AC_000158.1.551 E1BM70 CCD39_BOVIN 96.072 0.997877 1 CCDC39 - Coiled-coil domain-containing protein 39 - Bos taurus (Bovine) - CCDC39 gene Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly. Taurus_UMD|evm.model.AC_000158.1.552 Q96N46 TTC14_HUMAN 90.544 0.997409 1.0026 TTC14 - Tetratricopeptide repeat protein 14 - Homo sapiens (Human) - TTC14 gene Taurus_UMD|evm.model.AC_000158.1.553 O02751 CFDP2_BOVIN 72.374 0.762048 0.560811 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000158.1.554 Q76B49 CD63_FELCA 82.090 0.902778 0.302521 CD63 - CD63 antigen - Felis catus (Cat) - CD63 gene Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli (By similarity). Taurus_UMD|evm.model.AC_000158.1.555 Q925N3 PEX5R_RAT 96.179 0.996683 1.00166 Pex5l - PEX5-related protein - Rattus norvegicus (Rat) - Pex5l gene Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence. Taurus_UMD|evm.model.AC_000158.1.556 E1BMF7 UBP13_BOVIN 96.640 0.997611 0.969873 USP13 - Ubiquitin carboxyl-terminal hydrolase 13 - Bos taurus (Bovine) - USP13 gene Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data. Taurus_UMD|evm.model.AC_000158.1.557 Q02380 NDUB5_BOVIN 100.000 0.989474 1.00529 NDUFB5 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor - Bos taurus (Bovine) - NDUFB5 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000158.1.558 Q08DT6 RM47_BOVIN 98.413 0.992095 1.00397 MRPL47 - 39S ribosomal protein L47, mitochondrial precursor - Bos taurus (Bovine) - MRPL47 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Taurus_UMD|evm.model.AC_000158.1.559 O96019 ACL6A_HUMAN 99.534 0.995349 1.00233 ACTL6A - Actin-like protein 6A - Homo sapiens (Human) - ACTL6A gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Taurus_UMD|evm.model.AC_000158.1.560 Q9HAV0 GBB4_HUMAN 95.882 0.993902 0.964706 GNB4 - Guanine nucleotide-binding protein subunit beta-4 - Homo sapiens (Human) - GNB4 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Taurus_UMD|evm.model.AC_000158.1.561 Q811U4 MFN1_MOUSE 94.054 0.994616 1.0027 Mfn1 - Mitofusin-1 - Mus musculus (Mouse) - Mfn1 gene Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12527753, PubMed:23921378, PubMed:24513856, PubMed:15297672). Membrane clustering requires GTPase activity (By similarity). It may involve a major rearrangement of the coiled coil domains (PubMed:15297672). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12527753). Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity (By similarity). Taurus_UMD|evm.model.AC_000158.1.562 A5PK30 ZN639_BOVIN 100.000 0.995885 1.00206 ZNF639 - Zinc finger protein 639 - Bos taurus (Bovine) - ZNF639 gene Binds DNA and may function as a transcriptional repressor. Taurus_UMD|evm.model.AC_000158.1.563 Q4R506 RL7_MACFA 76.000 0.981707 0.663968 RPL7 - 60S ribosomal protein L7 - Macaca fascicularis (Crab-eating macaque) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Taurus_UMD|evm.model.AC_000158.1.564 Q9NPA1 KCMB3_HUMAN 77.778 0.645429 1.29391 KCNMB3 - Calcium-activated potassium channel subunit beta-3 - Homo sapiens (Human) - KCNMB3 gene Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. Taurus_UMD|evm.model.AC_000158.1.565 P32871 PK3CA_BOVIN 98.876 0.99811 0.990637 PIK3CA - Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform - Bos taurus (Bovine) - PIK3CA gene Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:1322797, PubMed:14729945). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway (By similarity). In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others (PubMed:15178440, PubMed:14729945). Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity). Taurus_UMD|evm.model.AC_000158.1.566 Q0IIC4 ZMAT3_BOVIN 100.000 0.993103 1.00346 ZMAT3 - Zinc finger matrin-type protein 3 - Bos taurus (Bovine) - ZMAT3 gene Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus (By similarity). Taurus_UMD|evm.model.AC_000158.1.567 Q9Y691 KCMB2_HUMAN 99.574 0.869888 1.14468 KCNMB2 - Calcium-activated potassium channel subunit beta-2 - Homo sapiens (Human) - KCNMB2 gene Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. Taurus_UMD|evm.model.AC_000158.1.568 F1N5S9 FUND1_BOVIN 98.261 0.982759 0.748387 FUNDC1 - FUN14 domain-containing protein 1 - Bos taurus (Bovine) - FUNDC1 gene Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. Taurus_UMD|evm.model.AC_000158.1.569 Q86UB2 BIVM_HUMAN 77.510 0.819549 0.528827 BIVM - Basic immunoglobulin-like variable motif-containing protein - Homo sapiens (Human) - BIVM gene extracellular space Taurus_UMD|evm.model.AC_000158.1.572 Q9BZK7 TBL1R_HUMAN 99.222 0.996117 1.00195 TBL1XR1 - F-box-like/WD repeat-containing protein TBL1XR1 - Homo sapiens (Human) - TBL1XR1 gene F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. Taurus_UMD|evm.model.AC_000158.1.575 P21329 RTJK_DROFU 28.205 0.566176 0.296943 jockey\pol - RNA-directed DNA polymerase from mobile element jockey - Drosophila funebris (Fruit fly) - jockey\pol gene Taurus_UMD|evm.model.AC_000158.1.577 Q58DX5 NADL2_HUMAN 85.528 0.998374 0.773585 NAALADL2 - Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 - Homo sapiens (Human) - NAALADL2 gene May be catalytically inactive. Taurus_UMD|evm.model.AC_000158.1.578 Q28554 G3P_SHEEP 98.095 0.981132 0.329193 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Ovis aries (Sheep) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Taurus_UMD|evm.model.AC_000158.1.580 Q8N2Q7 NLGN1_HUMAN 99.836 0.982201 0.716107 NLGN1 - Neuroligin-1 precursor - Homo sapiens (Human) - NLGN1 gene Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (By similarity). The protein is involved in nervous system development. Taurus_UMD|evm.model.AC_000158.1.581 O15439 MRP4_HUMAN 70.690 0.129545 0.664151 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000158.1.582 Q63HK3 ZKSC2_HUMAN 77.686 0.696154 0.537746 ZKSCAN2 - Zinc finger protein with KRAB and SCAN domains 2 - Homo sapiens (Human) - ZKSCAN2 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000158.1.583 P62936 PPIA_PIG 95.000 0.846154 0.713415 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Taurus_UMD|evm.model.AC_000158.1.585 P10854 H2B1M_MOUSE 91.270 0.984252 1.00794 H2bc14 - Histone H2B type 1-M - Mus musculus (Mouse) - H2bc14 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000158.1.586 Q4R3V2 SPT16_MACFA 88.889 0.996303 0.950791 SPATA16 - Spermatogenesis-associated protein 16 - Macaca fascicularis (Crab-eating macaque) - SPATA16 gene Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. Taurus_UMD|evm.model.AC_000158.1.587 Q9H8V3 ECT2_HUMAN 94.092 0.997814 1.00109 ECT2 - Protein ECT2 - Homo sapiens (Human) - ECT2 gene Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. Taurus_UMD|evm.model.AC_000158.1.588 Q1JQE6 NCEH1_BOVIN 100.000 0.99511 1.00245 NCEH1 - Neutral cholesterol ester hydrolase 1 - Bos taurus (Bovine) - NCEH1 gene Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). May be responsible for cholesterol ester hydrolysis in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity). Taurus_UMD|evm.model.AC_000158.1.589 P50591 TNF10_HUMAN 68.858 0.993056 1.02491 TNFSF10 - Tumor necrosis factor ligand superfamily member 10 - Homo sapiens (Human) - TNFSF10 gene Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Taurus_UMD|evm.model.AC_000158.1.590 A5A4L1 GHSR_MUSPF 96.995 0.99455 1.00273 GHSR - Growth hormone secretagogue receptor type 1 - Mustela putorius furo (European domestic ferret) - GHSR gene Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine) (By similarity). Taurus_UMD|evm.model.AC_000158.1.591 Q53EP0 FND3B_HUMAN 96.437 0.998344 1.00332 FNDC3B - Fibronectin type III domain-containing protein 3B - Homo sapiens (Human) - FNDC3B gene May be a positive regulator of adipogenesis. Taurus_UMD|evm.model.AC_000158.1.592 A5D787 M17L2_BOVIN 98.795 0.988024 0.766055 MPV17L2 - Mpv17-like protein 2 - Bos taurus (Bovine) - MPV17L2 gene Required for the assembly and stability of the mitochondrial ribosome (By similarity). Is a positive regulator of mitochondrial protein synthesis (By similarity). Taurus_UMD|evm.model.AC_000158.1.593 A6NML5 TM212_HUMAN 80.110 0.952381 0.974227 TMEM212 - Transmembrane protein 212 - Homo sapiens (Human) - TMEM212 gene Taurus_UMD|evm.model.AC_000158.1.595 Q13393 PLD1_HUMAN 91.814 0.99814 1.00093 PLD1 - Phospholipase D1 - Homo sapiens (Human) - PLD1 gene Function as phospholipase selective for phosphatidylcholine (PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). Taurus_UMD|evm.model.AC_000158.1.596 P58351 GTR2_BOVIN 100.000 0.250678 3.61373 SLC2A2 - Solute carrier family 2, facilitated glucose transporter member 2 - Bos taurus (Bovine) - SLC2A2 gene Facilitative hexose transporter that mediates the transport of glucose and fructose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate. Taurus_UMD|evm.model.AC_000158.1.597 Q3SX40 PDLI7_BOVIN 63.889 0.572581 0.292453 PDLIM7 - PDZ and LIM domain protein 7 - Bos taurus (Bovine) - PDLIM7 gene May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). Taurus_UMD|evm.model.AC_000158.1.598 Q5R898 IF5A2_PONAB 100.000 0.987013 1.00654 EIF5A2 - Eukaryotic translation initiation factor 5A-2 - Pongo abelii (Sumatran orangutan) - EIF5A2 gene mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). Taurus_UMD|evm.model.AC_000158.1.599 A4FUH0 RL22L_BOVIN 99.180 0.98374 1.0082 RPL22L1 - 60S ribosomal protein L22-like 1 - Bos taurus (Bovine) - RPL22L1 gene RNA binding, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000158.1.600 A0JNI9 S7A14_BOVIN 100.000 0.851371 0.898833 SLC7A14 - Probable cationic amino acid transporter - Bos taurus (Bovine) - SLC7A14 gene plasma membrane, amino acid transmembrane transporter activity, amino acid transport Taurus_UMD|evm.model.AC_000158.1.601 Q3MHK4 CLD11_BOVIN 99.517 0.985646 1.00966 CLDN11 - Claudin-11 - Bos taurus (Bovine) - CLDN11 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Taurus_UMD|evm.model.AC_000158.1.602 Q5R431 SKIL_PONAB 90.949 0.99708 1.00146 SKIL - Ski-like protein - Pongo abelii (Sumatran orangutan) - SKIL gene May have regulatory role in cell division or differentiation in response to extracellular signals. Taurus_UMD|evm.model.AC_000158.1.603 Q5R4K9 KPCI_PONAB 99.497 0.99665 1.00168 PRKCI - Protein kinase C iota type - Pongo abelii (Sumatran orangutan) - PRKCI gene Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis (By similarity). Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). Taurus_UMD|evm.model.AC_000158.1.604 Q8NDX5 PHC3_HUMAN 96.646 0.985958 1.01424 PHC3 - Polyhomeotic-like protein 3 - Homo sapiens (Human) - PHC3 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Taurus_UMD|evm.model.AC_000158.1.605 Q9UJ42 GP160_HUMAN 81.361 0.994083 1 GPR160 - Probable G-protein coupled receptor 160 - Homo sapiens (Human) - GPR160 gene Orphan receptor. Taurus_UMD|evm.model.AC_000158.1.606 Q3T171 RL36_BOVIN 92.553 0.877358 1.00952 RPL36 - 60S ribosomal protein L36 - Bos taurus (Bovine) - RPL36 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000158.1.607 Q99442 SEC62_HUMAN 97.995 0.995 1.00251 SEC62 - Translocation protein SEC62 - Homo sapiens (Human) - SEC62 gene Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. Taurus_UMD|evm.model.AC_000158.1.608 Q7Z3H4 SAMD7_HUMAN 71.552 0.942935 0.825112 SAMD7 - Sterile alpha motif domain-containing protein 7 - Homo sapiens (Human) - SAMD7 gene Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes. Taurus_UMD|evm.model.AC_000158.1.609 Q6UY01 LRC31_HUMAN 72.904 0.952849 0.922101 LRRC31 - Leucine-rich repeat-containing protein 31 - Homo sapiens (Human) - LRRC31 gene Taurus_UMD|evm.model.AC_000158.1.610 A6NIV6 LRIQ4_HUMAN 60.794 0.854664 0.823214 LRRIQ4 - Leucine-rich repeat and IQ domain-containing protein 4 - Homo sapiens (Human) - LRRIQ4 gene cytoplasm, intracellular membrane-bounded organelle, protein serine/threonine phosphatase activity, signal transduction Taurus_UMD|evm.model.AC_000158.1.611 Q8IZ02 LRC34_HUMAN 80.876 0.955752 0.974138 LRRC34 - Leucine-rich repeat-containing protein 34 - Homo sapiens (Human) - LRRC34 gene Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. Taurus_UMD|evm.model.AC_000158.1.612 Q9NPC7 MYNN_HUMAN 92.561 0.879205 1.07213 MYNN - Myoneurin - Homo sapiens (Human) - MYNN gene nucleoplasm, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000158.1.613 Q9BYD9 ACTT3_HUMAN 80.645 0.834091 1.1828 ACTRT3 - Actin-related protein T3 - Homo sapiens (Human) - ACTRT3 gene Taurus_UMD|evm.model.AC_000158.1.615 O75095 MEGF6_HUMAN 52.397 0.91195 0.20636 MEGF6 - Multiple epidermal growth factor-like domains protein 6 precursor - Homo sapiens (Human) - MEGF6 gene Taurus_UMD|evm.model.AC_000158.1.616 Q0D2K5 EGFEM_HUMAN 54.194 0.280734 2.79487 EGFEM1P - Putative EGF-like and EMI domain-containing protein 1 - Homo sapiens (Human) - EGFEM1P gene Taurus_UMD|evm.model.AC_000158.1.617 Q95SX7 RTBS_DROME 29.747 0.410667 0.413907 RTase - Probable RNA-directed DNA polymerase from transposon BS - Drosophila melanogaster (Fruit fly) - RTase gene RNA-directed DNA polymerase activity, transposition, DNA-mediated Taurus_UMD|evm.model.AC_000158.1.618 Q8C088 EGFEM_MOUSE 62.069 0.727848 0.267797 Egfem1 - EGF-like and EMI domain-containing protein 1 precursor - Mus musculus (Mouse) - Egfem1 gene Taurus_UMD|evm.model.AC_000158.1.621 O00461 GOLI4_HUMAN 81.636 0.997006 0.95977 GOLIM4 - Golgi integral membrane protein 4 - Homo sapiens (Human) - GOLIM4 gene Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. Taurus_UMD|evm.model.AC_000158.1.622 Q28CU0 LRC23_XENTR 30.769 0.416342 0.734286 lrrc23 - Leucine-rich repeat-containing protein 23 - Xenopus tropicalis (Western clawed frog) - lrrc23 gene Taurus_UMD|evm.model.AC_000158.1.624 Q99574 NEUS_HUMAN 84.878 0.994764 0.931707 SERPINI1 - Neuroserpin precursor - Homo sapiens (Human) - SERPINI1 gene Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076, PubMed:26329378, PubMed:19265707, PubMed:19285087, PubMed:11880376). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable). Taurus_UMD|evm.model.AC_000158.1.625 Q8VE70 PDC10_MOUSE 100.000 0.99061 1.00472 Pdcd10 - Programmed cell death protein 10 - Mus musculus (Mouse) - Pdcd10 gene Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex (By similarity). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Taurus_UMD|evm.model.AC_000158.1.626 Q8IV35 WDR49_HUMAN 79.157 0.571635 0.991392 WDR49 - WD repeat-containing protein 49 - Homo sapiens (Human) - WDR49 gene Taurus_UMD|evm.model.AC_000158.1.627 O75830 SPI2_HUMAN 84.938 0.995074 1.00247 SERPINI2 - Serpin I2 precursor - Homo sapiens (Human) - SERPINI2 gene extracellular exosome, extracellular space, serine-type endopeptidase inhibitor activity, negative regulation of endopeptidase activity Taurus_UMD|evm.model.AC_000158.1.628 A8MT70 ZBBX_HUMAN 75.472 0.981308 0.13375 ZBBX - Zinc finger B-box domain-containing protein 1 - Homo sapiens (Human) - ZBBX gene motile cilium, cilium movement Taurus_UMD|evm.model.AC_000158.1.629 A8MT70 ZBBX_HUMAN 68.103 0.980226 0.885 ZBBX - Zinc finger B-box domain-containing protein 1 - Homo sapiens (Human) - ZBBX gene motile cilium, cilium movement Taurus_UMD|evm.model.AC_000158.1.630 P61246 RS3A_FELCA 47.347 0.862745 0.784615 RPS3A - 40S ribosomal protein S3a - Felis catus (Cat) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Taurus_UMD|evm.model.AC_000158.1.631 P32749 CHLE_BOVIN 100.000 0.996683 1.00166 BCHE - Cholinesterase precursor - Bos taurus (Bovine) - BCHE gene Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). Taurus_UMD|evm.model.AC_000158.1.632 O94933 SLIK3_HUMAN 97.446 0.996942 1.00409 SLITRK3 - SLIT and NTRK-like protein 3 precursor - Homo sapiens (Human) - SLITRK3 gene Suppresses neurite outgrowth. Taurus_UMD|evm.model.AC_000158.1.633 P14410 SUIS_HUMAN 80.679 0.98235 0.992337 SI - Sucrase-isomaltase, intestinal - Homo sapiens (Human) - SI gene Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides. Taurus_UMD|evm.model.AC_000158.1.634 P02584 PROF1_BOVIN 98.571 0.985816 1.00714 PFN1 - Profilin-1 - Bos taurus (Bovine) - PFN1 gene Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). Taurus_UMD|evm.model.AC_000158.1.635 P31622 GAG_JSRV 40.530 0.915789 0.465686 gag - Gag polyprotein - Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) - gag gene Matrix protein. Taurus_UMD|evm.model.AC_000158.1.636 P62907 RL10A_RAT 97.696 0.990826 1.00461 Rpl10a - 60S ribosomal protein L10a - Rattus norvegicus (Rat) - Rpl10a gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000158.1.638 Q9Y448 SKAP_HUMAN 73.640 0.990521 0.667722 KNSTRN - Small kinetochore-associated protein - Homo sapiens (Human) - KNSTRN gene Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). Taurus_UMD|evm.model.AC_000158.1.641 A6NHN0 OTOL1_HUMAN 77.917 0.995781 0.993711 OTOL1 - Otolin-1 precursor - Homo sapiens (Human) - OTOL1 gene Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Acts as a scaffold for biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OC90, modulates calcite crystal morphology and growth kinetics. Taurus_UMD|evm.model.AC_000158.1.642 Q93079 H2B1H_HUMAN 94.030 0.942857 0.555556 H2BC9 - Histone H2B type 1-H - Homo sapiens (Human) - H2BC9 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000158.1.643 Q2KJ61 ELP3_BOVIN 88.320 0.962422 0.875686 ELP3 - Elongator complex protein 3 - Bos taurus (Bovine) - ELP3 gene Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity). Taurus_UMD|evm.model.AC_000158.1.644 Q08DS5 NMD3_BOVIN 100.000 0.996032 1.00199 NMD3 - 60S ribosomal export protein NMD3 - Bos taurus (Bovine) - NMD3 gene Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. Taurus_UMD|evm.model.AC_000158.1.646 Q864U6 B3GL1_PIG 96.979 0.993976 1.00302 B3GALNT1 - UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 - Sus scrofa (Pig) - B3GALNT1 gene Transfers N-acetylgalactosamine onto globotriaosylceramide. Plays a critical role in preimplantation stage embryonic development. Taurus_UMD|evm.model.AC_000158.1.647 A5PJZ2 PPM1L_BOVIN 100.000 0.99446 1.00278 PPM1L - Protein phosphatase 1L - Bos taurus (Bovine) - PPM1L gene Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Taurus_UMD|evm.model.AC_000158.1.648 Q5R1W0 ANXA5_PANTR 92.857 0.466102 0.36875 ANXA5 - Annexin A5 - Pan troglodytes (Chimpanzee) - ANXA5 gene This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Taurus_UMD|evm.model.AC_000158.1.649 P81287 ANXA5_BOVIN 96.859 0.989583 0.598131 ANXA5 - Annexin A5 - Bos taurus (Bovine) - ANXA5 gene This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Taurus_UMD|evm.model.AC_000158.1.650 Q8N4G2 ARL14_HUMAN 83.333 0.989637 1.00521 ARL14 - ADP-ribosylation factor-like protein 14 - Homo sapiens (Human) - ARL14 gene GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. Taurus_UMD|evm.model.AC_000158.1.651 O00629 IMA3_HUMAN 99.808 0.996169 1.00192 KPNA4 - Importin subunit alpha-3 - Homo sapiens (Human) - KPNA4 gene Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Taurus_UMD|evm.model.AC_000158.1.653 Q8IWR1 TRI59_HUMAN 87.841 0.995037 1 TRIM59 - Tripartite motif-containing protein 59 - Homo sapiens (Human) - TRIM59 gene May serve as a multifunctional regulator for innate immune signaling pathways. Taurus_UMD|evm.model.AC_000158.1.654 Q9NTJ3 SMC4_HUMAN 93.251 0.998448 1.00078 SMC4 - Structural maintenance of chromosomes protein 4 - Homo sapiens (Human) - SMC4 gene Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Taurus_UMD|evm.model.AC_000158.1.655 Q9P2H3 IFT80_HUMAN 90.625 0.161783 1.0103 IFT80 - Intraflagellar transport protein 80 homolog - Homo sapiens (Human) - IFT80 gene Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia. Taurus_UMD|evm.model.AC_000158.1.656 F5H4A9 CC080_HUMAN 86.345 0.991903 1 C3orf80 - Uncharacterized membrane protein C3orf80 precursor - Homo sapiens (Human) - C3orf80 gene Taurus_UMD|evm.model.AC_000158.1.657 O70511 ANK3_RAT 32.143 0.159844 0.195652 Ank3 - Ankyrin-3 - Rattus norvegicus (Rat) - Ank3 gene Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (By similarity). Taurus_UMD|evm.model.AC_000158.1.658 P54349 IL12A_BOVIN 100.000 0.990991 1.00452 IL12A - Interleukin-12 subunit alpha precursor - Bos taurus (Bovine) - IL12A gene Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Taurus_UMD|evm.model.AC_000158.1.659 B3KU38 IQIP1_HUMAN 93.576 0.86729 0.950266 IQCJ-SCHIP1 - IQCJ-SCHIP1 readthrough transcript protein - Homo sapiens (Human) - IQCJ-SCHIP1 gene May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25950943). May also play a role in axon outgrowth and guidance (By similarity). Taurus_UMD|evm.model.AC_000158.1.660 P00011 CYC_CANLF 75.238 0.980952 1 CYCS - Cytochrome c - Canis lupus familiaris (Dog) - CYCS gene Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Taurus_UMD|evm.model.AC_000158.1.661 Q1A5X6 IQCJ_HUMAN 88.235 0.807229 0.522013 IQCJ - IQ domain-containing protein J - Homo sapiens (Human) - IQCJ gene Taurus_UMD|evm.model.AC_000158.1.662 P41231 P2RY2_HUMAN 45.724 0.822404 0.970822 P2RY2 - P2Y purinoceptor 2 - Homo sapiens (Human) - P2RY2 gene Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. Taurus_UMD|evm.model.AC_000158.1.663 Q1JQC1 MFSD1_BOVIN 100.000 0.995736 1.00214 MFSD1 - Major facilitator superfamily domain-containing protein 1 - Bos taurus (Bovine) - MFSD1 gene Lysosomal transporter which is essential for liver homeostasis. Required to maintain stability and lysosomal localization of GLMP. Taurus_UMD|evm.model.AC_000158.1.664 P49788 TIG1_HUMAN 64.966 0.992565 0.914966 RARRES1 - Retinoic acid receptor responder protein 1 - Homo sapiens (Human) - RARRES1 gene Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle. Taurus_UMD|evm.model.AC_000158.1.665 Q8K0D5 EFGM_MOUSE 93.227 0.997347 1.00399 Gfm1 - Elongation factor G, mitochondrial precursor - Mus musculus (Mouse) - Gfm1 gene Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Taurus_UMD|evm.model.AC_000158.1.666 Q32KY3 MLF1_BOVIN 95.070 0.992982 1.05556 MLF1 - Myeloid leukemia factor 1 - Bos taurus (Bovine) - MLF1 gene Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus (By similarity). Taurus_UMD|evm.model.AC_000158.1.667 Q2T9Y0 RSRC1_BOVIN 100.000 0.99403 1.00299 RSRC1 - Serine/Arginine-related protein 53 - Bos taurus (Bovine) - RSRC1 gene Plays a role in pre-mRNA splicing. Involved both in the constitutive and regulation of pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing (By similarity). Taurus_UMD|evm.model.AC_000158.1.669 O35750 SHOX2_RAT 97.890 0.710843 1.40084 Shox2 - Short stature homeobox protein 2 - Rattus norvegicus (Rat) - Shox2 gene May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. Taurus_UMD|evm.model.AC_000158.1.671 Q14D04 MELT_HUMAN 89.962 0.997462 0.945978 VEPH1 - Ventricular zone-expressed PH domain-containing protein homolog 1 - Homo sapiens (Human) - VEPH1 gene Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. Taurus_UMD|evm.model.AC_000158.1.672 O00370 LORF2_HUMAN 74.747 0.989967 0.23451 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000158.1.673 Q52KE7 CCNL1_MOUSE 100.000 0.705202 0.325188 Ccnl1 - Cyclin-L1 - Mus musculus (Mouse) - Ccnl1 gene Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). May play a role in the regulation of RNA polymerase II (pol II). Inhibited by the CDK-specific inhibitor CDKN1A/p21. Taurus_UMD|evm.model.AC_000158.1.674 Q9UK58 CCNL1_HUMAN 98.082 0.978495 0.707224 CCNL1 - Cyclin-L1 - Homo sapiens (Human) - CCNL1 gene Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036). Taurus_UMD|evm.model.AC_000158.1.675 Q6ZMV7 LEKR1_HUMAN 81.443 0.643927 1.54897 LEKR1 - Leucine-, glutamate- and lysine-rich protein 1 - Homo sapiens (Human) - LEKR1 gene Taurus_UMD|evm.model.AC_000158.1.679 Q7Z3E1 PARPT_HUMAN 94.825 0.996956 1 TIPARP - Protein mono-ADP-ribosyltransferase TIPARP - Homo sapiens (Human) - TIPARP gene ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (PubMed:23275542, PubMed:30373764). Taurus_UMD|evm.model.AC_000158.1.680 Q3SZ87 SSRG_BOVIN 100.000 0.989247 1.00541 SSR3 - Translocon-associated protein subunit gamma - Bos taurus (Bovine) - SSR3 gene TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Taurus_UMD|evm.model.AC_000158.1.681 P63144 KCAB1_RAT 100.000 0.995025 1.00249 Kcnab1 - Voltage-gated potassium channel subunit beta-1 - Rattus norvegicus (Rat) - Kcnab1 gene Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its effect on the pore-forming alpha subunits (Probable). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:8183366, PubMed:15618540, PubMed:18222921). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:10064591, PubMed:10650996, PubMed:16504945). Accelerates KCNA4 channel closure (PubMed:8183366). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:16504945). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (PubMed:15618540). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity. Has NADPH-dependent aldoketoreductase activity (PubMed:18222921). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (PubMed:18222921, PubMed:21436029). Taurus_UMD|evm.model.AC_000158.1.682 Q4R7Y2 RL10_MACFA 66.667 0.630952 0.392523 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000158.1.683 Q14722 KCAB1_HUMAN 81.319 0.661765 0.324582 KCNAB1 - Voltage-gated potassium channel subunit beta-1 - Homo sapiens (Human) - KCNAB1 gene Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity). Taurus_UMD|evm.model.AC_000158.1.684 O70410 V2R1_MOUSE 71.130 0.435662 0.596491 Vmn2r1 - Vomeronasal type-2 receptor 1 precursor - Mus musculus (Mouse) - Vmn2r1 gene Putative pheromone receptor. Taurus_UMD|evm.model.AC_000158.1.685 P49915 GUAA_HUMAN 98.830 0.988423 0.997114 GMPS - GMP synthase [glutamine-hydrolyzing] - Homo sapiens (Human) - GMPS gene Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. Taurus_UMD|evm.model.AC_000158.1.686 Q5E951 TBCB_BOVIN 92.958 0.864198 0.331967 TBCB - Tubulin-folding cofactor B - Bos taurus (Bovine) - TBCB gene Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. Taurus_UMD|evm.model.AC_000158.1.687 O00400 ACATN_HUMAN 92.545 0.99637 1.00364 SLC33A1 - Acetyl-coenzyme A transporter 1 - Homo sapiens (Human) - SLC33A1 gene Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides (PubMed:9096318). Negatively regulates BMP signaling (PubMed:25402622). Taurus_UMD|evm.model.AC_000158.1.688 Q6P1S2 CC033_HUMAN 67.918 0.987854 0.840136 C3orf33 - Protein C3orf33 - Homo sapiens (Human) - C3orf33 gene Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane. Taurus_UMD|evm.model.AC_000158.1.690 Q4KWH8 PLCH1_HUMAN 83.542 0.998745 0.940933 PLCH1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 - Homo sapiens (Human) - PLCH1 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. Taurus_UMD|evm.model.AC_000158.1.691 Q4R7Y2 RL10_MACFA 63.492 0.635417 0.448598 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000158.1.692 P07861 NEP_RAT 91.333 0.997337 1.00133 Mme - Neprilysin - Rattus norvegicus (Rat) - Mme gene Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:2966343) (By similarity). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:2966343) (By similarity). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:2966343) (By similarity). Involved in the degradation of the atrial natriuretic factor (ANF) (PubMed:2966343). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (By similarity). Taurus_UMD|evm.model.AC_000158.1.694 Q86SP6 GP149_HUMAN 83.378 0.995984 1.02189 GPR149 - Probable G-protein coupled receptor 149 - Homo sapiens (Human) - GPR149 gene Orphan receptor. Taurus_UMD|evm.model.AC_000158.1.695 Q05B79 DHX36_BOVIN 100.000 0.998022 1.00099 DHX36 - ATP-dependent DNA/RNA helicase DHX36 - Bos taurus (Bovine) - DHX36 gene Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:29899445). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (By similarity). G4 structures correspond to helical structures containing guanine tetrads (PubMed:29899445). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) (PubMed:29899445) (By similarity). Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (By similarity). Plays a role in transcriptional regulation. Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (By similarity). Plays a role in post-transcriptional regulation. Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (By similarity). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (By similarity). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (By similarity). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (By similarity). Binds also to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (By similarity). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for the early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity). Taurus_UMD|evm.model.AC_000158.1.698 P68511 1433F_RAT 70.000 0.40625 0.390244 Ywhah - 14-3-3 protein eta - Rattus norvegicus (Rat) - Ywhah gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). Taurus_UMD|evm.model.AC_000158.1.700 Q8NI27 THOC2_HUMAN 97.446 0.333552 0.956058 THOC2 - THO complex subunit 2 - Homo sapiens (Human) - THOC2 gene Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development. Taurus_UMD|evm.model.AC_000158.1.701 P61227 RAP2B_RAT 99.454 0.98913 1.00546 Rap2b - Ras-related protein Rap-2b precursor - Rattus norvegicus (Rat) - Rap2b gene Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells (By similarity). Taurus_UMD|evm.model.AC_000158.1.702 P48042 P2RY1_BOVIN 100.000 0.994652 1.00268 P2RY1 - P2Y purinoceptor 1 - Bos taurus (Bovine) - P2RY1 gene Receptor for extracellular adenine nucleotides such as ADP (PubMed:7626079). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity). Taurus_UMD|evm.model.AC_000158.1.703 Q920A7 AFG31_MOUSE 74.359 0.8 0.183777 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Taurus_UMD|evm.model.AC_000158.1.704 Q2TBY0 SKA2_BOVIN 97.521 0.983607 1.00826 SKA2 - Spindle and kinetochore-associated protein 2 - Bos taurus (Bovine) - SKA2 gene Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. Taurus_UMD|evm.model.AC_000158.1.705 Q9NR56 MBNL1_HUMAN 93.035 0.995025 1.03608 MBNL1 - Muscleblind-like protein 1 - Homo sapiens (Human) - MBNL1 gene Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues. Taurus_UMD|evm.model.AC_000158.1.706 Q9BXA5 SUCR1_HUMAN 78.931 0.993691 0.949102 SUCNR1 - Succinate receptor 1 - Homo sapiens (Human) - SUCNR1 gene Receptor for succinate. Taurus_UMD|evm.model.AC_000158.1.707 Q0P5B7 AAAD_BOVIN 89.189 0.604938 0.609023 AADAC - Arylacetamide deacetylase - Bos taurus (Bovine) - AADAC gene Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity (By similarity). Taurus_UMD|evm.model.AC_000158.1.708 Q0P5B7 AAAD_BOVIN 99.749 0.995 1.00251 AADAC - Arylacetamide deacetylase - Bos taurus (Bovine) - AADAC gene Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity (By similarity). Taurus_UMD|evm.model.AC_000158.1.709 Q0P5B7 AAAD_BOVIN 73.684 0.982143 0.140351 AADAC - Arylacetamide deacetylase - Bos taurus (Bovine) - AADAC gene Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity (By similarity). Taurus_UMD|evm.model.AC_000158.1.710 Q7M370 AAAD_RABIT 77.876 0.658824 0.427136 AADAC - Arylacetamide deacetylase - Oryctolagus cuniculus (Rabbit) - AADAC gene Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity (By similarity). Taurus_UMD|evm.model.AC_000158.1.711 Q6P093 ADCL2_HUMAN 66.569 0.991254 0.855362 AADACL2 - Arylacetamide deacetylase-like 2 precursor - Homo sapiens (Human) - AADACL2 gene hydrolase activity Taurus_UMD|evm.model.AC_000158.1.712 Q6P093 ADCL2_HUMAN 51.714 0.996875 0.798005 AADACL2 - Arylacetamide deacetylase-like 2 precursor - Homo sapiens (Human) - AADACL2 gene hydrolase activity Taurus_UMD|evm.model.AC_000158.1.713 Q3SX46 C1GLC_BOVIN 86.164 0.99373 1.00314 C1GALT1C1 - C1GALT1-specific chaperone 1 - Bos taurus (Bovine) - C1GALT1C1 gene Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) (By similarity). Taurus_UMD|evm.model.AC_000158.1.714 Q6WRI0 IGS10_HUMAN 73.578 0.999151 0.897827 IGSF10 - Immunoglobulin superfamily member 10 precursor - Homo sapiens (Human) - IGSF10 gene Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity). Taurus_UMD|evm.model.AC_000158.1.715 Q86YW9 MD12L_HUMAN 97.159 0.999069 1.0014 MED12L - Mediator of RNA polymerase II transcription subunit 12-like protein - Homo sapiens (Human) - MED12L gene May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Taurus_UMD|evm.model.AC_000158.1.717 A8MYZ0 MIY4B_HUMAN 79.319 0.97619 0.913043 MINDY4B - Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B - Homo sapiens (Human) - MINDY4B gene Lys48-specific deubiquitinase activity Taurus_UMD|evm.model.AC_000158.1.718 O43255 SIAH2_HUMAN 96.988 0.993994 1.02778 SIAH2 - E3 ubiquitin-protein ligase SIAH2 - Homo sapiens (Human) - SIAH2 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:9334332, PubMed:11483518, PubMed:19224863). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:9334332, PubMed:11483518, PubMed:19224863). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:9334332, PubMed:11483518, PubMed:19224863). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:9334332, PubMed:11483518, PubMed:19224863). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia (PubMed:22878263). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (PubMed:9334332, PubMed:11483518, PubMed:19224863, PubMed:22878263). Has some overlapping function with SIAH1 (PubMed:9334332, PubMed:11483518, PubMed:19224863). Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not (PubMed:12411493). Promotes monoubiquitination of SNCA (PubMed:19224863). Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation (PubMed:26392558). Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Taurus_UMD|evm.model.AC_000158.1.719 Q7L0X2 ERIP6_HUMAN 75.290 0.894188 1.01207 ERICH6 - Glutamate-rich protein 6 - Homo sapiens (Human) - ERICH6 gene Taurus_UMD|evm.model.AC_000158.1.720 A6QP01 SELT_BOVIN 96.410 0.793249 1.21538 SELENOT - Thioredoxin reductase-like selenoprotein T precursor - Bos taurus (Bovine) - SELENOT gene Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (By similarity). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity). Taurus_UMD|evm.model.AC_000158.1.721 Q9BY44 EIF2A_HUMAN 93.717 0.954925 1.02393 EIF2A - Eukaryotic translation initiation factor 2A - Homo sapiens (Human) - EIF2A gene Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. Taurus_UMD|evm.model.AC_000158.1.722 Q9R2C1 SERP1_RAT 100.000 0.262136 1.56061 Serp1 - Stress-associated endoplasmic reticulum protein 1 - Rattus norvegicus (Rat) - Serp1 gene Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins. Taurus_UMD|evm.model.AC_000158.1.723 O75157 T22D2_HUMAN 84.547 0.997423 0.994872 TSC22D2 - TSC22 domain family protein 2 - Homo sapiens (Human) - TSC22D2 gene Taurus_UMD|evm.model.AC_000158.1.724 Q9JJV2 PROF2_MOUSE 100.000 0.985816 1.00714 Pfn2 - Profilin-2 - Mus musculus (Mouse) - Pfn2 gene Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Taurus_UMD|evm.model.AC_000158.1.725 Q0VD51 RNF13_BOVIN 100.000 0.994751 1.00263 RNF13 - E3 ubiquitin-protein ligase RNF13 precursor - Bos taurus (Bovine) - RNF13 gene E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. Taurus_UMD|evm.model.AC_000158.1.727 A6NFN9 ANKUB_HUMAN 82.669 0.917431 1.08566 ANKUB1 - Protein ANKUB1 - Homo sapiens (Human) - ANKUB1 gene Taurus_UMD|evm.model.AC_000158.1.728 Q86X83 COMD2_HUMAN 91.720 0.96875 0.80402 COMMD2 - COMM domain-containing protein 2 - Homo sapiens (Human) - COMMD2 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Taurus_UMD|evm.model.AC_000158.1.729 Q9GZV5 WWTR1_HUMAN 97.500 0.845339 1.18 WWTR1 - WW domain-containing transcription regulator protein 1 - Homo sapiens (Human) - WWTR1 gene Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). Taurus_UMD|evm.model.AC_000158.1.730 Q91XD3 T4S4_MOUSE 85.027 0.911765 1.0099 Tm4sf4 - Transmembrane 4 L6 family member 4 - Mus musculus (Mouse) - Tm4sf4 gene Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000158.1.731 Q5RE43 T4S1_PONAB 86.139 0.990148 1.00495 TM4SF1 - Transmembrane 4 L6 family member 1 - Pongo abelii (Sumatran orangutan) - TM4SF1 gene Taurus_UMD|evm.model.AC_000158.1.732 Q3T110 T4S18_BOVIN 100.000 0.990099 1.00498 TM4SF18 - Transmembrane 4 L6 family member 18 - Bos taurus (Bovine) - TM4SF18 gene integral component of membrane Taurus_UMD|evm.model.AC_000158.1.733 Q9XT27 CERU_SHEEP 95.694 0.535421 1.85878 CP - Ceruloplasmin precursor - Ovis aries (Sheep) - CP gene Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane (By similarity). Taurus_UMD|evm.model.AC_000158.1.734 Q969F9 HPS3_HUMAN 89.442 0.998008 1 HPS3 - Hermansky-Pudlak syndrome 3 protein - Homo sapiens (Human) - HPS3 gene Involved in early stages of melanosome biogenesis and maturation. Taurus_UMD|evm.model.AC_000158.1.735 Q14527 HLTF_HUMAN 91.386 0.99802 1.00099 HLTF - Helicase-like transcription factor - Homo sapiens (Human) - HLTF gene Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. Taurus_UMD|evm.model.AC_000158.1.736 P13280 GLYG_RABIT 90.030 0.9375 1.05706 GYG1 - Glycogenin-1 - Oryctolagus cuniculus (Rabbit) - GYG1 gene Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. Taurus_UMD|evm.model.AC_000158.1.737 P15088 CBPA3_HUMAN 85.132 0.995215 1.0024 CPA3 - Mast cell carboxypeptidase A precursor - Homo sapiens (Human) - CPA3 gene collagen-containing extracellular matrix, extracellular region, extracellular space, secretory granule, metallocarboxypeptidase activity, angiotensin maturation, proteolysis Taurus_UMD|evm.model.AC_000158.1.738 P00732 CBPB1_BOVIN 100.000 0.995215 1.0024 CPB1 - Carboxypeptidase B precursor - Bos taurus (Bovine) - CPB1 gene extracellular space, metallocarboxypeptidase activity, proteolysis Taurus_UMD|evm.model.AC_000158.1.739 P25104 AGTR1_BOVIN 100.000 0.994444 1.00279 AGTR1 - Type-1 angiotensin II receptor - Bos taurus (Bovine) - AGTR1 gene Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000158.1.741 Q9D287 SPF27_MOUSE 100.000 0.90566 0.706667 Bcas2 - Pre-mRNA-splicing factor SPF27 - Mus musculus (Mouse) - Bcas2 gene Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). Taurus_UMD|evm.model.AC_000158.1.742 O02751 CFDP2_BOVIN 67.066 0.733945 0.368243 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000158.1.743 Q10126 YSM6_CAEEL 27.326 0.553957 0.996416 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000158.1.744 Q2YDK4 HMGN4_BOVIN 93.333 0.978022 1.01111 HMGN4 - High mobility group nucleosome-binding domain-containing protein 4 - Bos taurus (Bovine) - HMGN4 gene nucleus, chromatin binding, chromatin organization Taurus_UMD|evm.model.AC_000158.1.745 P10076 ZFP26_MOUSE 53.955 0.64794 0.620209 Zfp26 - Zinc finger protein 26 - Mus musculus (Mouse) - Zfp26 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000158.1.746 Q8JJC0 ZIC1_CHICK 93.995 0.924939 0.93018 ZIC1 - Zinc finger protein ZIC 1 - Gallus gallus (Chicken) - ZIC1 gene Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). Taurus_UMD|evm.model.AC_000158.1.747 Q8N9L1 ZIC4_HUMAN 93.134 0.860825 1.16168 ZIC4 - Zinc finger protein ZIC 4 - Homo sapiens (Human) - ZIC4 gene Binds to DNA. Taurus_UMD|evm.model.AC_000158.1.748 A0PG75 PLS5_HUMAN 95.055 0.937824 0.712177 PLSCR5 - Phospholipid scramblase family member 5 - Homo sapiens (Human) - PLSCR5 gene plasma membrane, phospholipid scramblase activity, plasma membrane phospholipid scrambling Taurus_UMD|evm.model.AC_000158.1.749 Q3ZBG9 PLS2_BOVIN 100.000 0.993197 1.00341 PLSCR2 - Phospholipid scramblase 2 - Bos taurus (Bovine) - PLSCR2 gene May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system (By similarity). Taurus_UMD|evm.model.AC_000158.1.750 Q9JJ00 PLS1_MOUSE 56.322 0.96648 0.545732 Plscr1 - Phospholipid scramblase 1 - Mus musculus (Mouse) - Plscr1 gene Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific distribution of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (PubMed:32110987). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (PubMed:32110987). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (By similarity). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (PubMed:26745724). May contribute to cytokine-regulated cell proliferation and differentiation (PubMed:12010804). Taurus_UMD|evm.model.AC_000158.1.751 Q9NRQ2 PLS4_HUMAN 81.402 0.979042 1.0152 PLSCR4 - Phospholipid scramblase 4 - Homo sapiens (Human) - PLSCR4 gene May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Taurus_UMD|evm.model.AC_000158.1.752 O00469 PLOD2_HUMAN 91.601 0.997379 1.03528 PLOD2 - Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 precursor - Homo sapiens (Human) - PLOD2 gene Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. Taurus_UMD|evm.model.AC_000158.1.753 P09104 ENOG_HUMAN 71.642 0.725275 0.209677 ENO2 - Gamma-enolase - Homo sapiens (Human) - ENO2 gene Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). Taurus_UMD|evm.model.AC_000158.1.754 Q8NDZ4 DIK2A_HUMAN 99.767 0.99536 1.00233 DIPK2A - Divergent protein kinase domain 2A precursor - Homo sapiens (Human) - DIPK2A gene May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade. Taurus_UMD|evm.model.AC_000158.1.755 Q8IVB4 SL9A9_HUMAN 96.032 0.809677 0.48062 SLC9A9 - Sodium/hydrogen exchanger 9 - Homo sapiens (Human) - SLC9A9 gene May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell. Taurus_UMD|evm.model.AC_000158.1.756 Q8BZ00 SL9A9_MOUSE 94.350 0.647059 0.42236 Slc9a9 - Sodium/hydrogen exchanger 9 - Mus musculus (Mouse) - Slc9a9 gene May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell (By similarity). Taurus_UMD|evm.model.AC_000158.1.758 P16423 POLR_DROME 29.464 0.70347 0.299905 pol - Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM - Drosophila melanogaster (Fruit fly) - pol gene Taurus_UMD|evm.model.AC_000158.1.759 Q9Y4C5 CHST2_HUMAN 94.151 0.996212 0.996226 CHST2 - Carbohydrate sulfotransferase 2 - Homo sapiens (Human) - CHST2 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains. Taurus_UMD|evm.model.AC_000158.1.760 O15042 SR140_HUMAN 99.514 0.998058 1.00097 U2SURP - U2 snRNP-associated SURP motif-containing protein - Homo sapiens (Human) - U2SURP gene nucleoplasm, nucleus, RNA binding, mRNA splicing, via spliceosome Taurus_UMD|evm.model.AC_000158.1.761 Q6ZVX9 PAQR9_HUMAN 92.838 0.994709 1.00265 PAQR9 - Membrane progestin receptor epsilon - Homo sapiens (Human) - PAQR9 gene Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870). Taurus_UMD|evm.model.AC_000158.1.762 O46415 FRIL_BOVIN 94.771 0.987013 0.88 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000158.1.763 Q9UKZ9 PCOC2_HUMAN 92.788 0.995204 1.00482 PCOLCE2 - Procollagen C-endopeptidase enhancer 2 precursor - Homo sapiens (Human) - PCOLCE2 gene Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1. Taurus_UMD|evm.model.AC_000158.1.764 P48995 TRPC1_HUMAN 99.622 0.986318 1.01387 TRPC1 - Short transient receptor potential channel 1 - Homo sapiens (Human) - TRPC1 gene Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. Taurus_UMD|evm.model.AC_000158.1.765 A6H742 PLSI_BOVIN 100.000 0.99683 1.00159 PLS1 - Plastin-1 - Bos taurus (Bovine) - PLS1 gene Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions. Taurus_UMD|evm.model.AC_000158.1.766 Q13535 ATR_HUMAN 93.653 0.999244 1.00038 ATR - Serine/threonine-protein kinase ATR - Homo sapiens (Human) - ATR gene Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity). Taurus_UMD|evm.model.AC_000158.1.767 Q8IZH2 XRN1_HUMAN 89.908 0.998851 1.02052 XRN1 - 5'-3' exoribonuclease 1 - Homo sapiens (Human) - XRN1 gene Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). Taurus_UMD|evm.model.AC_000158.1.768 Q08D86 GLPK5_BOVIN 91.667 0.996132 0.979167 GK5 - Putative glycerol kinase 5 - Bos taurus (Bovine) - GK5 gene mitochondrion, glycerol kinase activity, phosphotransferase activity, alcohol group as acceptor, glycerol metabolic process, glycerol-3-phosphate biosynthetic process, phosphorylation, triglyceride metabolic process Taurus_UMD|evm.model.AC_000158.1.769 Q14188 TFDP2_HUMAN 97.763 0.986726 1.01345 TFDP2 - Transcription factor Dp-2 - Homo sapiens (Human) - TFDP2 gene Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). Taurus_UMD|evm.model.AC_000158.1.772 P63324 RS12_RAT 85.124 0.983607 0.924242 Rps12 - 40S ribosomal protein S12 - Rattus norvegicus (Rat) - Rps12 gene cytosolic large ribosomal subunit, cytosolic small ribosomal subunit, structural constituent of ribosome, response to organonitrogen compound Taurus_UMD|evm.model.AC_000158.1.773 Q3T0C6 AT1B3_BOVIN 100.000 0.992857 1.00358 ATP1B3 - Sodium/potassium-transporting ATPase subunit beta-3 - Bos taurus (Bovine) - ATP1B3 gene This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity). Taurus_UMD|evm.model.AC_000158.1.774 Q8WMV0 GRK7_BOVIN 100.000 0.41623 0.692029 GRK7 - Rhodopsin kinase GRK7 precursor - Bos taurus (Bovine) - GRK7 gene Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). Taurus_UMD|evm.model.AC_000158.1.775 Q9WTZ1 RBX2_MOUSE 99.115 0.982456 1.00885 Rnf7 - RING-box protein 2 - Mus musculus (Mouse) - Rnf7 gene Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (By similarity). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents (By similarity). Taurus_UMD|evm.model.AC_000158.1.777 Q15283 RASA2_HUMAN 96.805 0.992933 0.998824 RASA2 - Ras GTPase-activating protein 2 - Homo sapiens (Human) - RASA2 gene Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4). Taurus_UMD|evm.model.AC_000158.1.778 Q5E984 TCTP_BOVIN 72.449 0.976471 0.494186 TPT1 - Translationally-controlled tumor protein - Bos taurus (Bovine) - TPT1 gene Involved in calcium binding and microtubule stabilization. Taurus_UMD|evm.model.AC_000158.1.779 Q8NAP3 ZBT38_HUMAN 88.787 0.99834 1.00837 ZBTB38 - Zinc finger and BTB domain-containing protein 38 - Homo sapiens (Human) - ZBTB38 gene Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). Taurus_UMD|evm.model.AC_000158.1.780 Q8TE99 PXYP1_HUMAN 87.500 0.782946 0.80625 PXYLP1 - 2-phosphoxylose phosphatase 1 - Homo sapiens (Human) - PXYLP1 gene Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. Taurus_UMD|evm.model.AC_000158.1.782 Q96A44 SPSB4_HUMAN 97.436 0.992701 1.00366 SPSB4 - SPRY domain-containing SOCS box protein 4 - Homo sapiens (Human) - SPSB4 gene Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21199876, PubMed:15601820). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 (PubMed:28931592). Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 (PubMed:26392558). Taurus_UMD|evm.model.AC_000158.1.784 Q96CQ1 S2536_HUMAN 97.106 0.99359 1.00322 SLC25A36 - Solute carrier family 25 member 36 - Homo sapiens (Human) - SLC25A36 gene Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. Taurus_UMD|evm.model.AC_000158.1.785 Q9D2H5 TRI42_MOUSE 88.966 0.997245 1.00415 Trim42 - Tripartite motif-containing protein 42 - Mus musculus (Mouse) - Trim42 gene chromatin, nucleoplasm, ubiquitin-protein transferase activity, positive regulation of transcription, DNA-templated Taurus_UMD|evm.model.AC_000158.1.786 Q8VDA1 CSTN2_RAT 93.004 0.926884 0.921244 Clstn2 - Calsyntenin-2 precursor - Rattus norvegicus (Rat) - Clstn2 gene May modulate calcium-mediated postsynaptic signals. Taurus_UMD|evm.model.AC_000158.1.789 Q99JR6 NMNA3_MOUSE 61.224 0.913208 1.08163 Nmnat3 - Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 - Mus musculus (Mouse) - Nmnat3 gene Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. Taurus_UMD|evm.model.AC_000158.1.790 Q0V7M0 IMA7_BOVIN 100.000 0.996255 0.996269 KPNA6 - Importin subunit alpha-7 - Bos taurus (Bovine) - KPNA6 gene Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Taurus_UMD|evm.model.AC_000158.1.791 P40222 TXLNA_HUMAN 89.502 0.996441 1.0293 TXLNA - Alpha-taxilin - Homo sapiens (Human) - TXLNA gene May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. Taurus_UMD|evm.model.AC_000158.1.793 P50121 RET2_PIG 91.045 0.985185 1.00746 RBP2 - Retinol-binding protein 2 - Sus scrofa (Pig) - RBP2 gene Intracellular transport of retinol. Taurus_UMD|evm.model.AC_000158.1.794 P35605 COPB2_BOVIN 100.000 0.803828 0.230684 COPB2 - Coatomer subunit beta' - Bos taurus (Bovine) - COPB2 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Taurus_UMD|evm.model.AC_000158.1.795 P82649 RT22_BOVIN 99.721 0.99169 1.00557 MRPS22 - 28S ribosomal protein S22, mitochondrial - Bos taurus (Bovine) - MRPS22 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000158.1.796 P35605 COPB2_BOVIN 99.711 0.994245 0.767108 COPB2 - Coatomer subunit beta' - Bos taurus (Bovine) - COPB2 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Taurus_UMD|evm.model.AC_000158.1.797 Q6ZRT6 PR23B_HUMAN 52.273 0.984615 0.981132 PRR23B - Proline-rich protein 23B - Homo sapiens (Human) - PRR23B gene Taurus_UMD|evm.model.AC_000158.1.799 A6NEV1 PR23A_HUMAN 48.519 0.875839 1.1203 PRR23A - Proline-rich protein 23A - Homo sapiens (Human) - PRR23A gene Taurus_UMD|evm.model.AC_000158.1.800 Q5RFL9 NONO_PONAB 100.000 0.977528 0.18896 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Taurus_UMD|evm.model.AC_000158.1.801 Q5RFL9 NONO_PONAB 97.486 0.994413 0.760085 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Taurus_UMD|evm.model.AC_000158.1.802 A6NEV1 PR23A_HUMAN 48.519 0.890785 1.1015 PRR23A - Proline-rich protein 23A - Homo sapiens (Human) - PRR23A gene Taurus_UMD|evm.model.AC_000158.1.803 Q6ZRT6 PR23B_HUMAN 42.294 0.985019 1.00755 PRR23B - Proline-rich protein 23B - Homo sapiens (Human) - PRR23B gene Taurus_UMD|evm.model.AC_000158.1.805 Q6ZRT6 PR23B_HUMAN 48.689 0.984733 0.988679 PRR23B - Proline-rich protein 23B - Homo sapiens (Human) - PRR23B gene Taurus_UMD|evm.model.AC_000158.1.806 Q6VFT7 FOXL2_BOVIN 100.000 0.994709 1.00265 FOXL2 - Forkhead box protein L2 - Bos taurus (Bovine) - FOXL2 gene Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination (By similarity). Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells (By similarity). Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Activates SIRT1 transcription under cellular stress conditions (By similarity). Activates transcription of OSR2 (By similarity). Is a regulator of CYP19 expression (By similarity). Is a transcriptional repressor of STAR (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Taurus_UMD|evm.model.AC_000158.1.808 Q2KMM2 TPPC1_RAT 65.672 0.88 0.517241 Trappc1 - Trafficking protein particle complex subunit 1 - Rattus norvegicus (Rat) - Trappc1 gene May play a role in vesicular transport from endoplasmic reticulum to Golgi. Taurus_UMD|evm.model.AC_000158.1.809 P42338 PK3CB_HUMAN 96.636 0.998133 1.00093 PIK3CB - Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform - Homo sapiens (Human) - PIK3CB gene Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Taurus_UMD|evm.model.AC_000158.1.810 Q0IIF6 FAIM1_BOVIN 100.000 0.990099 1.00498 FAIM - Fas apoptotic inhibitory molecule 1 - Bos taurus (Bovine) - FAIM gene Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells. Taurus_UMD|evm.model.AC_000158.1.811 Q5RDE3 CEP70_PONAB 87.392 0.996546 0.969849 CEP70 - Centrosomal protein of 70 kDa - Pongo abelii (Sumatran orangutan) - CEP70 gene Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle (By similarity). Taurus_UMD|evm.model.AC_000158.1.812 A0FGR9 ESYT3_HUMAN 84.199 0.997666 0.967269 ESYT3 - Extended synaptotagmin-3 - Homo sapiens (Human) - ESYT3 gene Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Taurus_UMD|evm.model.AC_000158.1.813 O14807 RASM_HUMAN 99.519 0.990431 1.00481 MRAS - Ras-related protein M-Ras precursor - Homo sapiens (Human) - MRAS gene Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway. Taurus_UMD|evm.model.AC_000158.1.814 Q86XW9 TXND6_HUMAN 76.149 0.608084 1.72424 NME9 - Thioredoxin domain-containing protein 6 - Homo sapiens (Human) - NME9 gene May be a regulator of microtubule physiology. Taurus_UMD|evm.model.AC_000158.1.815 Q2KI54 ARMC8_BOVIN 100.000 0.997033 1.00149 ARMC8 - Armadillo repeat-containing protein 8 - Bos taurus (Bovine) - ARMC8 gene Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Taurus_UMD|evm.model.AC_000158.1.816 Q9UK59 DBR1_HUMAN 88.411 0.979817 1.00184 DBR1 - Lariat debranching enzyme - Homo sapiens (Human) - DBR1 gene Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis. Taurus_UMD|evm.model.AC_000158.1.817 Q9UNA3 A4GCT_HUMAN 81.846 0.947368 1.00588 A4GNT - Alpha-1,4-N-acetylglucosaminyltransferase - Homo sapiens (Human) - A4GNT gene Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans (PubMed:10430883). Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (PubMed:10430883). May protect against inflammation-associated gastric adenocarcinomas (By similarity). Taurus_UMD|evm.model.AC_000158.1.818 Q5XIA0 DZI1L_RAT 90.419 0.648438 0.329897 Dzip1l - Zinc finger protein DZIP1L - Rattus norvegicus (Rat) - Dzip1l gene Involved in primary cilium formation. Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane. Taurus_UMD|evm.model.AC_000158.1.819 Q8IYY4 DZI1L_HUMAN 76.117 0.87632 0.864407 DZIP1L - Zinc finger protein DZIP1L - Homo sapiens (Human) - DZIP1L gene Involved in primary cilium formation (PubMed:19852954, PubMed:28530676). Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane (PubMed:28530676). Taurus_UMD|evm.model.AC_000158.1.820 Q0VCN0 CLD18_BOVIN 100.000 0.992366 1.00383 CLDN18 - Claudin-18 - Bos taurus (Bovine) - CLDN18 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Taurus_UMD|evm.model.AC_000158.1.821 P56856 CLD18_HUMAN 75.342 0.818182 0.337165 CLDN18 - Claudin-18 - Homo sapiens (Human) - CLDN18 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Taurus_UMD|evm.model.AC_000158.1.823 P61259 SOX14_MACFA 100.000 0.991701 1.00417 SOX14 - Transcription factor SOX-14 - Macaca fascicularis (Crab-eating macaque) - SOX14 gene Acts as a negative regulator of transcription. Taurus_UMD|evm.model.AC_000158.1.824 Q6UXL0 I20RB_HUMAN 79.344 0.993464 0.983923 IL20RB - Interleukin-20 receptor subunit beta precursor - Homo sapiens (Human) - IL20RB gene The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24. Taurus_UMD|evm.model.AC_000158.1.825 P16333 NCK1_HUMAN 98.939 0.994709 1.00265 NCK1 - Cytoplasmic protein NCK1 - Homo sapiens (Human) - NCK1 gene Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. Taurus_UMD|evm.model.AC_000158.1.826 Q8TBE7 S35G2_HUMAN 94.903 0.995146 1 SLC35G2 - Solute carrier family 35 member G2 - Homo sapiens (Human) - SLC35G2 gene May play a role in cell proliferation. Taurus_UMD|evm.model.AC_000158.1.827 Q2TBR6 PFD4_BOVIN 88.889 0.715328 1.02239 PFDN4 - Prefoldin subunit 4 - Bos taurus (Bovine) - PFDN4 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Taurus_UMD|evm.model.AC_000158.1.828 Q8WVM7 STAG1_HUMAN 99.762 0.998411 1.00079 STAG1 - Cohesin subunit SA-1 - Homo sapiens (Human) - STAG1 gene Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Taurus_UMD|evm.model.AC_000158.1.829 Q2TBR0 PCCB_BOVIN 100.000 0.996296 1.00186 PCCB - Propionyl-CoA carboxylase beta chain, mitochondrial precursor - Bos taurus (Bovine) - PCCB gene This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). Taurus_UMD|evm.model.AC_000158.1.830 Q9HCI7 MSL2_HUMAN 98.787 0.99654 1.00173 MSL2 - E3 ubiquitin-protein ligase MSL2 - Homo sapiens (Human) - MSL2 gene Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. Taurus_UMD|evm.model.AC_000158.1.831 Q06190 P2R3A_HUMAN 90.009 0.998262 1.00087 PPP2R3A - Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha - Homo sapiens (Human) - PPP2R3A gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Taurus_UMD|evm.model.AC_000158.1.832 O02751 CFDP2_BOVIN 73.684 0.460815 0.538851 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000158.1.834 P54762 EPHB1_HUMAN 98.515 0.773077 0.264228 EPHB1 - Ephrin type-B receptor 1 precursor - Homo sapiens (Human) - EPHB1 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). Taurus_UMD|evm.model.AC_000158.1.835 P54762 EPHB1_HUMAN 96.700 0.918206 0.770325 EPHB1 - Ephrin type-B receptor 1 precursor - Homo sapiens (Human) - EPHB1 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). Taurus_UMD|evm.model.AC_000158.1.837 Q8NBH2 KY_HUMAN 76.418 0.996716 0.921331 KY - Kyphoscoliosis peptidase - Homo sapiens (Human) - KY gene Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity). Taurus_UMD|evm.model.AC_000158.1.838 Q5NVN6 CEP63_PONAB 89.610 0.258503 0.543438 CEP63 - Centrosomal protein of 63 kDa - Pongo abelii (Sumatran orangutan) - CEP63 gene Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). Taurus_UMD|evm.model.AC_000158.1.839 Q5NVN6 CEP63_PONAB 86.318 0.995037 0.744917 CEP63 - Centrosomal protein of 63 kDa - Pongo abelii (Sumatran orangutan) - CEP63 gene Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). Taurus_UMD|evm.model.AC_000158.1.840 Q9BS18 APC13_HUMAN 100.000 0.973333 1.01351 ANAPC13 - Anaphase-promoting complex subunit 13 - Homo sapiens (Human) - ANAPC13 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Taurus_UMD|evm.model.AC_000158.1.841 F1MRK3 AMOL2_BOVIN 100.000 0.997392 1.00131 AMOTL2 - Angiomotin-like protein 2 - Bos taurus (Bovine) - AMOTL2 gene Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (By similarity). Taurus_UMD|evm.model.AC_000158.1.842 P34925 RYK_HUMAN 97.751 0.938211 1.01318 RYK - Tyrosine-protein kinase RYK precursor - Homo sapiens (Human) - RYK gene May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. Taurus_UMD|evm.model.AC_000158.1.843 Q92959 SO2A1_HUMAN 83.540 0.996899 1.00311 SLCO2A1 - Solute carrier organic anion transporter family member 2A1 - Homo sapiens (Human) - SLCO2A1 gene Transports PGD2, as well as PGE1, PGE2 and PGF2A. Mediates the clearance of prostaglandins from the circulation through uptake across cell membrane which allows cytoplasmic oxidation and prostaglandin signal termination (PubMed:8787677). May mediate the release of newly synthesized prostaglandins from cells and the transepithelial transport of prostaglandins (Probable). Taurus_UMD|evm.model.AC_000158.1.844 P61294 RAB6B_MOUSE 100.000 0.990431 1.00481 Rab6b - Ras-related protein Rab-6B - Mus musculus (Mouse) - Rab6b gene Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (By similarity). Taurus_UMD|evm.model.AC_000158.1.845 Q9Y5M8 SRPRB_HUMAN 92.620 0.909091 1.09594 SRPRB - Signal recognition particle receptor subunit beta - Homo sapiens (Human) - SRPRB gene Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity). Taurus_UMD|evm.model.AC_000158.1.846 Q29443 TRFE_BOVIN 99.290 0.997163 1.00142 TF - Serotransferrin precursor - Bos taurus (Bovine) - TF gene Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Taurus_UMD|evm.model.AC_000158.1.847 Q29545 ICA_PIG 82.411 0.997159 1 ICA - Inhibitor of carbonic anhydrase precursor - Sus scrofa (Pig) - ICA gene Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. Taurus_UMD|evm.model.AC_000158.1.848 Q92547 TOPB1_HUMAN 89.763 0.947876 1.02102 TOPBP1 - DNA topoisomerase 2-binding protein 1 - Homo sapiens (Human) - TOPBP1 gene Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042). Taurus_UMD|evm.model.AC_000158.1.849 Q9UKY7 CDV3_HUMAN 91.085 0.992248 1 CDV3 - Protein CDV3 homolog - Homo sapiens (Human) - CDV3 gene cytoplasm, cytosol, plasma membrane Taurus_UMD|evm.model.AC_000158.1.850 Q28177 BFSP2_BOVIN 78.838 0.989899 0.477108 BFSP2 - Phakinin - Bos taurus (Bovine) - BFSP2 gene Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). Plays a role in maintenance of retinal lens optical clarity (By similarity). Taurus_UMD|evm.model.AC_000158.1.851 Q28177 BFSP2_BOVIN 88.144 0.674825 0.689157 BFSP2 - Phakinin - Bos taurus (Bovine) - BFSP2 gene Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). Plays a role in maintenance of retinal lens optical clarity (By similarity). Taurus_UMD|evm.model.AC_000158.1.852 A6QLF8 TM108_BOVIN 99.657 0.996575 1.00172 TMEM108 - Transmembrane protein 108 - Bos taurus (Bovine) - TMEM108 gene Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes. Taurus_UMD|evm.model.AC_000158.1.853 P63172 DYLT1_HUMAN 97.345 0.982456 1.00885 DYNLT1 - Dynein light chain Tctex-type 1 - Homo sapiens (Human) - DYNLT1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. Taurus_UMD|evm.model.AC_000158.1.854 Q7Z494 NPHP3_HUMAN 95.342 0.998498 1.0015 NPHP3 - Nephrocystin-3 - Homo sapiens (Human) - NPHP3 gene Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. Taurus_UMD|evm.model.AC_000158.1.855 A7MAZ3 UBA5_BOVIN 100.000 0.995062 1.00248 UBA5 - Ubiquitin-like modifier-activating enzyme 5 - Bos taurus (Bovine) - UBA5 gene E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP. Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding. Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (By similarity). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). Taurus_UMD|evm.model.AC_000158.1.856 Q709F0 ACD11_HUMAN 77.382 0.997323 0.957692 ACAD11 - Acyl-CoA dehydrogenase family member 11 - Homo sapiens (Human) - ACAD11 gene Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA (PubMed:21237683). Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain (Probable). Taurus_UMD|evm.model.AC_000158.1.857 O75165 DJC13_HUMAN 97.414 0.999109 1.00045 DNAJC13 - DnaJ homolog subfamily C member 13 - Homo sapiens (Human) - DNAJC13 gene Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499). Taurus_UMD|evm.model.AC_000158.1.858 A6H730 PPAP_BOVIN 100.000 0.902381 1.08527 ACP3 - Prostatic acid phosphatase precursor - Bos taurus (Bovine) - ACP3 gene A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity). Taurus_UMD|evm.model.AC_000158.1.859 Q96L42 KCNH8_HUMAN 88.587 0.979657 0.843722 KCNH8 - Potassium voltage-gated channel subfamily H member 8 - Homo sapiens (Human) - KCNH8 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Taurus_UMD|evm.model.AC_000158.1.860 Q96A23 CPNE4_HUMAN 99.167 0.252654 0.845601 CPNE4 - Copine-4 - Homo sapiens (Human) - CPNE4 gene Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Taurus_UMD|evm.model.AC_000158.1.861 Q3ZBX6 RM03_BOVIN 100.000 0.994269 1.00287 MRPL3 - 39S ribosomal protein L3, mitochondrial precursor - Bos taurus (Bovine) - MRPL3 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000158.1.862 A1A4Q9 NUD16_BOVIN 100.000 0.989796 1.00513 NUDT16 - U8 snoRNA-decapping enzyme - Bos taurus (Bovine) - NUDT16 gene RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP. Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Taurus_UMD|evm.model.AC_000158.1.863 Q8WNU8 NEK11_MACFA 82.258 0.401316 0.238619 NEK11 - Serine/threonine-protein kinase Nek11 - Macaca fascicularis (Crab-eating macaque) - NEK11 gene Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. Taurus_UMD|evm.model.AC_000158.1.864 Q8NG66 NEK11_HUMAN 77.675 0.815534 0.95814 NEK11 - Serine/threonine-protein kinase Nek11 - Homo sapiens (Human) - NEK11 gene Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. Taurus_UMD|evm.model.AC_000158.1.865 Q2TB18 ASTE1_HUMAN 79.136 0.982353 1.00147 ASTE1 - Protein asteroid homolog 1 - Homo sapiens (Human) - ASTE1 gene Possible role in EGF receptor signaling. Taurus_UMD|evm.model.AC_000158.1.866 P57709 AT2C1_BOVIN 99.891 0.996739 0.965373 ATP2C1 - Calcium-transporting ATPase type 2C member 1 - Bos taurus (Bovine) - ATP2C1 gene ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (By similarity). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (By similarity). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology. Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (By similarity). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (By similarity). Taurus_UMD|evm.model.AC_000158.1.867 P63174 RL38_RAT 92.857 0.627273 1.57143 Rpl38 - 60S ribosomal protein L38 - Rattus norvegicus (Rat) - Rpl38 gene cytosolic large ribosomal subunit, eukaryotic 80S initiation complex, polysomal ribosome, postsynaptic density, synapse, structural constituent of ribosome, 90S preribosome assembly, axial mesoderm development, cytoplasmic translation, middle ear morphogenesis Taurus_UMD|evm.model.AC_000158.1.868 Q0P5F2 PSMG1_BOVIN 100.000 0.99308 1.00347 PSMG1 - Proteasome assembly chaperone 1 - Bos taurus (Bovine) - PSMG1 gene Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity). Taurus_UMD|evm.model.AC_000158.1.869 Q9NSI6 BRWD1_HUMAN 88.541 0.999135 0.996983 BRWD1 - Bromodomain and WD repeat-containing protein 1 - Homo sapiens (Human) - BRWD1 gene May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Taurus_UMD|evm.model.AC_000158.1.870 P02316 HMGN1_BOVIN 100.000 0.980392 1.0099 HMGN1 - Non-histone chromosomal protein HMG-14 - Bos taurus (Bovine) - HMGN1 gene Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). Taurus_UMD|evm.model.AC_000158.1.871 Q3SZ26 GET1_BOVIN 100.000 0.865 1.14943 GET1 - Guided entry of tail-anchored proteins factor 1 - Bos taurus (Bovine) - GET1 gene Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required to ensure correct topology and ER insertion of CAMLG. Taurus_UMD|evm.model.AC_000158.1.872 A7E3D8 LCA5L_BOVIN 93.185 0.997222 1.07463 LCA5L - Lebercilin-like protein - Bos taurus (Bovine) - LCA5L gene axoneme, intraciliary transport Taurus_UMD|evm.model.AC_000158.1.873 P55822 SH3BG_HUMAN 90.370 0.770115 0.728033 SH3BGR - SH3 domain-binding glutamic acid-rich protein - Homo sapiens (Human) - SH3BGR gene cytosol, protein-containing complex assembly Taurus_UMD|evm.model.AC_000158.1.874 Q9Y2C3 B3GT5_HUMAN 67.638 0.987179 1.00645 B3GALT5 - Beta-1,3-galactosyltransferase 5 - Homo sapiens (Human) - B3GALT5 gene Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor. Taurus_UMD|evm.model.AC_000158.1.875 Q9NSI5 IGSF5_HUMAN 63.679 0.649231 0.798526 IGSF5 - Immunoglobulin superfamily member 5 - Homo sapiens (Human) - IGSF5 gene Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells (By similarity). Taurus_UMD|evm.model.AC_000158.1.876 P63055 PCP4_RAT 93.333 0.278481 2.54839 Pcp4 - Calmodulin regulator protein PCP4 - Rattus norvegicus (Rat) - Pcp4 gene Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls. For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways. Taurus_UMD|evm.model.AC_000158.1.877 O60469 DSCAM_HUMAN 95.874 0.998888 0.894135 DSCAM - Down syndrome cell adhesion molecule precursor - Homo sapiens (Human) - DSCAM gene Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). Taurus_UMD|evm.model.AC_000158.1.880 O60469 DSCAM_HUMAN 95.597 0.644898 0.121769 DSCAM - Down syndrome cell adhesion molecule precursor - Homo sapiens (Human) - DSCAM gene Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). Taurus_UMD|evm.model.AC_000158.1.881 Q9Y5Z0 BACE2_HUMAN 90.818 0.961165 0.994208 BACE2 - Beta-secretase 2 precursor - Homo sapiens (Human) - BACE2 gene Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142). Taurus_UMD|evm.model.AC_000158.1.882 P15475 ACTB_XENBO 86.111 0.882716 0.430851 actb - Actin, cytoplasmic 1 - Xenopus borealis (Kenyan clawed frog) - actb gene Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Taurus_UMD|evm.model.AC_000158.1.883 Q11212 ACT_SPOLI 86.538 0.703448 0.884146 Actin - Spodoptera littoralis (Egyptian cotton leafworm) Taurus_UMD|evm.model.AC_000158.1.884 Q9BDI7 MX2_BOVIN 99.859 0.804767 1.24085 MX2 - Interferon-induced GTP-binding protein Mx2 - Bos taurus (Bovine) - MX2 gene Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV). Taurus_UMD|evm.model.AC_000158.1.885 P79135 MX1_BOVIN 99.083 0.996947 1.0108 MX1 - Interferon-induced GTP-binding protein Mx1 - Bos taurus (Bovine) - MX1 gene Interferon-induced dynamin-like GTPase with antiviral activity against rabies virus (RABV), vesicular stomatitis virus (VSV) and murine pneumonia virus (MPV). Isoform 1 but not isoform 2 shows antiviral activity against vesicular stomatitis virus (VSV). Taurus_UMD|evm.model.AC_000158.1.886 O15393 TMPS2_HUMAN 78.411 0.947573 1.04675 TMPRSS2 - Transmembrane protease serine 2 precursor - Homo sapiens (Human) - TMPRSS2 gene Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). Taurus_UMD|evm.model.AC_000158.1.887 Q9ERK0 RIPK4_MOUSE 88.041 0.997455 1 Ripk4 - Receptor-interacting serine/threonine-protein kinase 4 - Mus musculus (Mouse) - Ripk4 gene Involved in stratified epithelial development (By similarity). It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. Taurus_UMD|evm.model.AC_000158.1.888 P57071 PRD15_HUMAN 97.778 0.0387324 0.753816 PRDM15 - PR domain zinc finger protein 15 - Homo sapiens (Human) - PRDM15 gene Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264). Taurus_UMD|evm.model.AC_000158.1.889 Q9Y426 C2CD2_HUMAN 74.605 0.995702 1.00287 C2CD2 - C2 domain-containing protein 2 - Homo sapiens (Human) - C2CD2 gene cytosol, nucleus Taurus_UMD|evm.model.AC_000158.1.890 Q9ULJ3 ZBT21_HUMAN 73.620 0.998092 0.983114 ZBTB21 - Zinc finger and BTB domain-containing protein 21 - Homo sapiens (Human) - ZBTB21 gene Acts as a transcription repressor. Taurus_UMD|evm.model.AC_000158.1.891 Q5DID0 UROL1_HUMAN 64.659 0.998545 1.04325 UMODL1 - Uromodulin-like 1 precursor - Homo sapiens (Human) - UMODL1 gene apical plasma membrane, cell surface, extracellular space, extracellular matrix structural constituent, neutrophil migration Taurus_UMD|evm.model.AC_000158.1.892 Q64343 ABCG1_MOUSE 93.713 0.996997 1 Abcg1 - ATP-binding cassette sub-family G member 1 - Mus musculus (Mouse) - Abcg1 gene Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP (PubMed:14668945). The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (By similarity). Taurus_UMD|evm.model.AC_000158.1.893 A8YXX7 TFF3_BOVIN 98.765 0.833333 1.18519 TFF3 - Trefoil factor 3 precursor - Bos taurus (Bovine) - TFF3 gene Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity). Taurus_UMD|evm.model.AC_000158.1.894 P01359 TFF2_PIG 79.091 0.838462 1.02362 TFF2 - Trefoil factor 2 precursor - Sus scrofa (Pig) - TFF2 gene Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. Taurus_UMD|evm.model.AC_000158.1.895 Q863T4 TFF1_CANLF 64.474 0.386598 2.39506 TFF1 - Trefoil factor 1 precursor - Canis lupus familiaris (Dog) - TFF1 gene Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. Taurus_UMD|evm.model.AC_000158.1.896 P57727 TMPS3_HUMAN 90.423 0.921649 1.06828 TMPRSS3 - Transmembrane protease serine 3 - Homo sapiens (Human) - TMPRSS3 gene Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). Taurus_UMD|evm.model.AC_000158.1.897 Q3V3E1 UBS3A_MOUSE 78.247 0.996865 1.02244 Ubash3a - Ubiquitin-associated and SH3 domain-containing protein A - Mus musculus (Mouse) - Ubash3a gene Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain (By similarity). Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. Taurus_UMD|evm.model.AC_000158.1.898 Q8WYR4 RSPH1_HUMAN 81.029 0.987055 1 RSPH1 - Radial spoke head 1 homolog - Homo sapiens (Human) - RSPH1 gene May play an important role in male meiosis (By similarity). It is necessary for proper building of the axonemal central pair and radial spokes. Taurus_UMD|evm.model.AC_000158.1.900 P57057 G6PT2_HUMAN 87.242 0.996255 1.00188 SLC37A1 - Glucose-6-phosphate exchanger SLC37A1 - Homo sapiens (Human) - SLC37A1 gene Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. Taurus_UMD|evm.model.AC_000158.1.901 O70628 PDE9A_MOUSE 91.031 0.979284 0.994382 Pde9a - High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A - Mus musculus (Mouse) - Pde9a gene Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes (PubMed:9624145). Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (PubMed:22328573, PubMed:24746365). Taurus_UMD|evm.model.AC_000158.1.902 A7E3S5 WDR4_BOVIN 100.000 0.995181 1.00242 WDR4 - tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 - Bos taurus (Bovine) - WDR4 gene Non-catalytic component of a methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs. Also required for methylation of a specific subset of miRNAs, such as let-7. Acts as a regulator of embryonic stem cell self-renewal and differentiation. Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1. Taurus_UMD|evm.model.AC_000158.1.903 P25712 NDUV3_BOVIN 100.000 0.105042 4.36697 NDUFV3 - NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial precursor - Bos taurus (Bovine) - NDUFV3 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I. Taurus_UMD|evm.model.AC_000158.1.904 Q2HJ84 PKNX1_BOVIN 100.000 0.995423 1.00229 PKNOX1 - Homeobox protein PKNOX1 - Bos taurus (Bovine) - PKNOX1 gene Activates transcription in the presence of PBX1A and HOXA1. Taurus_UMD|evm.model.AC_000158.1.905 P35520 CBS_HUMAN 86.980 0.965035 1.03811 CBS - Cystathionine beta-synthase - Homo sapiens (Human) - CBS gene Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:23981774, PubMed:20506325, PubMed:23974653). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). Taurus_UMD|evm.model.AC_000158.1.906 A1A4K8 U2AF1_BOVIN 97.046 0.991597 1.00422 U2AF1 - Splicing factor U2AF 35 kDa subunit - Bos taurus (Bovine) - U2AF1 gene Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity). Taurus_UMD|evm.model.AC_000158.1.907 P02470 CRYAA_BOVIN 100.000 0.815166 1.21965 CRYAA - Alpha-crystallin A chain - Bos taurus (Bovine) - CRYAA gene Contributes to the transparency and refractive index of the lens (By similarity). Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions (PubMed:20440841). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). Taurus_UMD|evm.model.AC_000158.1.911 Q17QV3 SUMO3_BOVIN 100.000 0.980952 1.00962 SUMO3 - Small ubiquitin-related modifier 3 precursor - Bos taurus (Bovine) - SUMO3 gene Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity). Taurus_UMD|evm.model.AC_000158.1.912 Q5NVI6 PTTG_PONAB 80.000 0.988636 0.977778 PTTG1IP - Pituitary tumor-transforming gene 1 protein-interacting protein precursor - Pongo abelii (Sumatran orangutan) - PTTG1IP gene May facilitate PTTG1 nuclear translocation. Taurus_UMD|evm.model.AC_000158.1.913 P32592 ITB2_BOVIN 100.000 0.916468 1.08973 ITGB2 - Integrin beta-2 precursor - Bos taurus (Bovine) - ITGB2 gene Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. Taurus_UMD|evm.model.AC_000158.1.914 P58468 F207A_MOUSE 69.725 0.986364 1.00457 Fam207a - Protein FAM207A - Mus musculus (Mouse) - Fam207a gene Taurus_UMD|evm.model.AC_000158.1.918 P51400 RED1_RAT 89.311 0.944669 1.04219 Adarb1 - Double-stranded RNA-specific editase 1 - Rattus norvegicus (Rat) - Adarb1 gene Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently (By similarity). Can inhibit cell proliferation and migration and can stimulate exocytosis. Taurus_UMD|evm.model.AC_000158.1.919 Q6EV56 OFUT2_PANTR 91.388 0.473864 2.05128 POFUT2 - GDP-fucose protein O-fucosyltransferase 2 precursor - Pan troglodytes (Chimpanzee) - POFUT2 gene Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS superfamily and the thrombosporin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13. O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). Taurus_UMD|evm.model.AC_000158.1.920 Q9UJW3 DNM3L_HUMAN 73.757 0.543675 1.72021 DNMT3L - DNA (cytosine-5)-methyltransferase 3-like - Homo sapiens (Human) - DNMT3L gene Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:17687327). Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:17687327). Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (PubMed:17687327). Plays a key role in embryonic stem cells and germ cells (By similarity). In germ cells, required for the methylation of imprinted loci together with DNMT3A (By similarity). In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (By similarity). Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (By similarity). While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (By similarity). Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (By similarity). Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity). Taurus_UMD|evm.model.AC_000158.1.921 O43918 AIRE_HUMAN 74.176 0.974026 0.988991 AIRE - Autoimmune regulator - Homo sapiens (Human) - AIRE gene Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (PubMed:26084028). Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program. Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression. Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes. In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection. In secondary lymphoid organs, induces functional inactivation of CD4(+) T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (By similarity). Taurus_UMD|evm.model.AC_000158.1.922 A1A4J1 PFKAL_BOVIN 100.000 0.997439 1.00128 PFKL - ATP-dependent 6-phosphofructokinase, liver type - Bos taurus (Bovine) - PFKL gene Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). Taurus_UMD|evm.model.AC_000158.1.923 O43822 CF410_HUMAN 73.541 0.992218 1.00391 CFAP410 - Cilia- and flagella-associated protein 410 - Homo sapiens (Human) - CFAP410 gene Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Involved in DNA damage repair (PubMed:26290490). Taurus_UMD|evm.model.AC_000158.1.925 O94759 TRPM2_HUMAN 79.278 0.992 0.998004 TRPM2 - Transient receptor potential cation channel subfamily M member 2 - Homo sapiens (Human) - TRPM2 gene Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11960981, PubMed:12594222, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:20660597, PubMed:25620041, PubMed:27383051, PubMed:27068538, PubMed:28775320, PubMed:29745897, PubMed:30467180). Functions as ligand-gated ion channel (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:30467180). Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:29745897, PubMed:30467180). Extracellular calcium passes through the channel and increases channel activity (PubMed:19171771). Contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed:25562606, PubMed:27068538). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Activated by intracellular ADP-ribose, beta-NAD (NAD(+)) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed:11960981, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:25620041, PubMed:27383051, PubMed:27068538, PubMed:30467180). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate (PubMed:20650899, PubMed:25918360). Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius) (PubMed:22493272). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (By similarity). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca(2+) and Zn(2+) levels (PubMed:27068538). Confers susceptibility to cell death following oxidative stress (PubMed:12594222, PubMed:25562606). Taurus_UMD|evm.model.AC_000158.1.926 A6H793 LRRC3_BOVIN 100.000 0.980843 1.01556 LRRC3 - Leucine-rich repeat-containing protein 3 precursor - Bos taurus (Bovine) - LRRC3 gene Taurus_UMD|evm.model.AC_000158.1.929 J3S6Y1 TSEAR_MOUSE 81.935 0.846154 0.271642 Tspear - Thrombospondin-type laminin G domain and EAR repeat-containing protein precursor - Mus musculus (Mouse) - Tspear gene Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system. Taurus_UMD|evm.model.AC_000158.1.931 Q8WU66 TSEAR_HUMAN 83.962 0.868583 0.727952 TSPEAR - Thrombospondin-type laminin G domain and EAR repeat-containing protein precursor - Homo sapiens (Human) - TSPEAR gene Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway (PubMed:27736875). May play a role in development or function of the auditory system (PubMed:22678063). Taurus_UMD|evm.model.AC_000158.1.933 Q8ILR9 YPF17_PLAF7 46.154 0.212707 0.0776491 PF14_0175 - Protein PF14_0175 - Plasmodium falciparum (isolate 3D7) - PF14_0175 gene Taurus_UMD|evm.model.AC_000158.1.934 Q8ILR9 YPF17_PLAF7 40.909 0.277955 0.0671386 PF14_0175 - Protein PF14_0175 - Plasmodium falciparum (isolate 3D7) - PF14_0175 gene Taurus_UMD|evm.model.AC_000158.1.935 Q8ILR9 YPF17_PLAF7 39.535 0.367965 0.0495495 PF14_0175 - Protein PF14_0175 - Plasmodium falciparum (isolate 3D7) - PF14_0175 gene Taurus_UMD|evm.model.AC_000158.1.941 P60409 KR107_HUMAN 64.151 0.47619 0.283784 KRTAP10-7 - Keratin-associated protein 10-7 - Homo sapiens (Human) - KRTAP10-7 gene In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. Taurus_UMD|evm.model.AC_000158.1.942 Q17QG5 UB2G2_BOVIN 100.000 0.979167 0.581818 UBE2G2 - Ubiquitin-conjugating enzyme E2 G2 - Bos taurus (Bovine) - UBE2G2 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation. Taurus_UMD|evm.model.AC_000158.1.944 P57059 SIK1_HUMAN 84.095 0.874814 0.85696 SIK1 - Serine/threonine-protein kinase SIK1 - Homo sapiens (Human) - SIK1 gene Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). Taurus_UMD|evm.model.AC_000158.1.947 O75031 HSF2B_HUMAN 89.706 0.690722 0.290419 HSF2BP - Heat shock factor 2-binding protein - Homo sapiens (Human) - HSF2BP gene Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination (By similarity) (PubMed:31242413). Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (By similarity). Required for proper recombinase recruitment in female meiosis (By similarity). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). May be involved in modulating HSF2 activation in testis (PubMed:9651507). Taurus_UMD|evm.model.AC_000158.1.948 O75031 HSF2B_HUMAN 81.509 0.827839 0.817365 HSF2BP - Heat shock factor 2-binding protein - Homo sapiens (Human) - HSF2BP gene Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination (By similarity) (PubMed:31242413). Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (By similarity). Required for proper recombinase recruitment in female meiosis (By similarity). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). May be involved in modulating HSF2 activation in testis (PubMed:9651507). Taurus_UMD|evm.model.AC_000158.1.949 Q14684 RRP1B_HUMAN 67.678 0.99729 0.973615 RRP1B - Ribosomal RNA processing protein 1 homolog B - Homo sapiens (Human) - RRP1B gene Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). Taurus_UMD|evm.model.AC_000158.1.950 Q0II59 PDXK_BOVIN 100.000 0.99361 1.00321 PDXK - Pyridoxal kinase - Bos taurus (Bovine) - PDXK gene Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (By similarity). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity). Taurus_UMD|evm.model.AC_000158.1.952 P35478 CYTX_BOVIN 99.010 0.980392 1.0099 Stefin-C - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000158.1.953 P25417 CYTB_BOVIN 98.980 0.979798 1.0102 CSTB - Cystatin-B - Bos taurus (Bovine) - CSTB gene This is an intracellular thiol proteinase inhibitor. Taurus_UMD|evm.model.AC_000158.1.954 P56183 RRP1_MOUSE 76.378 0.565996 0.904858 Rrp1 - Ribosomal RNA processing protein 1 homolog A - Mus musculus (Mouse) - Rrp1 gene Plays a critical role in the generation of 28S rRNA. Taurus_UMD|evm.model.AC_000158.1.956 Q9NRZ7 PLCC_HUMAN 93.351 0.994695 1.00266 AGPAT3 - 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma - Homo sapiens (Human) - AGPAT3 gene Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor (By similarity). Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity). Taurus_UMD|evm.model.AC_000158.1.959 P48553 TPC10_HUMAN 90.281 0.998395 0.989674 TRAPPC10 - Trafficking protein particle complex subunit 10 - Homo sapiens (Human) - TRAPPC10 gene Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether. Taurus_UMD|evm.model.AC_000158.1.960 Q15269 PWP2_HUMAN 90.461 0.988043 1.00109 PWP2 - Periodic tryptophan protein 2 homolog - Homo sapiens (Human) - PWP2 gene nucleoplasm, Pwp2p-containing subcomplex of 90S preribosome, small-subunit processome, RNA binding, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit assembly, rRNA processing Taurus_UMD|evm.model.AC_000158.1.961 A0A0B4J2D5 GAL3B_HUMAN 82.482 0.992647 1.01493 GATD3B - Glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial precursor - Homo sapiens (Human) - GATD3B gene mitochondrion Taurus_UMD|evm.model.AC_000158.1.963 P39060 COIA1_HUMAN 81.169 0.181228 0.965792 COL18A1 - Collagen alpha-1(XVIII) chain precursor - Homo sapiens (Human) - COL18A1 gene Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Taurus_UMD|evm.model.AC_000158.1.964 P41440 S19A1_HUMAN 67.767 0.963983 0.798646 SLC19A1 - Reduced folate transporter - Homo sapiens (Human) - SLC19A1 gene Transporter that mediates the import of reduced folates and a subset of cyclic dinucleotides (PubMed:7826387, PubMed:9041240, PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:31126740, PubMed:31511694). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803). Also able to mediate the import of antifolate drug methotrexate (PubMed:7615551, PubMed:7641195, PubMed:9767079, PubMed:22554803). Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP (PubMed:31126740, PubMed:31511694). Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of its substrates (PubMed:22554803, PubMed:31126740, PubMed:31511694). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803). Taurus_UMD|evm.model.AC_000158.1.966 P57722 PCBP3_MOUSE 97.832 0.678967 1.46092 Pcbp3 - Poly(rC)-binding protein 3 - Mus musculus (Mouse) - Pcbp3 gene Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Taurus_UMD|evm.model.AC_000158.1.968 Q04857 CO6A1_MOUSE 91.700 0.983463 1.00293 Col6a1 - Collagen alpha-1(VI) chain precursor - Mus musculus (Mouse) - Col6a1 gene Collagen VI acts as a cell-binding protein. Taurus_UMD|evm.model.AC_000158.1.969 Q02788 CO6A2_MOUSE 91.709 0.918216 1.04062 Col6a2 - Collagen alpha-2(VI) chain precursor - Mus musculus (Mouse) - Col6a2 gene Collagen VI acts as a cell-binding protein. Taurus_UMD|evm.model.AC_000158.1.972 P53603 FTCD_PIG 88.889 0.994465 1.00185 FTCD - Formimidoyltransferase-cyclodeaminase - Sus scrofa (Pig) - FTCD gene Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool. Taurus_UMD|evm.model.AC_000158.1.973 Q9D9W0 SPC1L_MOUSE 86.589 0.994186 1.00585 Spatc1l - Speriolin-like protein - Mus musculus (Mouse) - Spatc1l gene centrosome, sperm connecting piece, identical protein binding, protein kinase A regulatory subunit binding, actin polymerization or depolymerization, positive regulation of cAMP-dependent protein kinase activity, positive regulation of protein kinase A signaling, positive regulation of protein phosphorylation, spermatogenesis Taurus_UMD|evm.model.AC_000158.1.974 P84466 LSS_BOVIN 99.590 0.997271 1.00137 LSS - Lanosterol synthase - Bos taurus (Bovine) - LSS gene Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (PubMed:14678783). Through the production of lanosterol may regulate lens protein aggregation and increase transparency (By similarity). Taurus_UMD|evm.model.AC_000158.1.975 O60318 GANP_HUMAN 82.972 0.99899 1 MCM3AP - Germinal-center associated nuclear protein - Homo sapiens (Human) - MCM3AP gene As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:23591820, PubMed:22307388). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). Taurus_UMD|evm.model.AC_000158.1.976 P58557 YBEY_HUMAN 72.222 0.963964 0.664671 YBEY - Endoribonuclease YbeY - Homo sapiens (Human) - YBEY gene Single strand-specific metallo-endoribonuclease involved in rRNA maturation. Taurus_UMD|evm.model.AC_000158.1.977 P58505 CU058_HUMAN 59.729 0.655063 0.981366 C21orf58 - Uncharacterized protein C21orf58 - Homo sapiens (Human) - C21orf58 gene Taurus_UMD|evm.model.AC_000158.1.978 O95613 PCNT_HUMAN 63.636 0.0279115 0.934353 PCNT - Pericentrin - Homo sapiens (Human) - PCNT gene Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. Taurus_UMD|evm.model.AC_000158.1.979 Q14689 DIP2A_HUMAN 90.782 0.998722 0.996181 DIP2A - Disco-interacting protein 2 homolog A - Homo sapiens (Human) - DIP2A gene Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002). Taurus_UMD|evm.model.AC_000158.1.981 P02638 S100B_BOVIN 100.000 0.978495 1.01087 S100B - Protein S100-B - Bos taurus (Bovine) - S100B gene Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity). Taurus_UMD|evm.model.AC_000158.1.982 P55345 ANM2_HUMAN 85.945 0.801852 1.24711 PRMT2 - Protein arginine N-methyltransferase 2 - Homo sapiens (Human) - PRMT2 gene Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. Taurus_UMD|evm.model.AC_000158.1.983 O02747 AHR_RABIT 52.990 0.592221 0.940968 AHR - Aryl hydrocarbon receptor - Oryctolagus cuniculus (Rabbit) - AHR gene Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:9022676). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation. Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists. Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands. Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity). Taurus_UMD|evm.model.AC_000158.1.984 Q1RMS8 FBX25_BOVIN 99.721 0.994429 1.0056 FBXO25 - F-box only protein 25 - Bos taurus (Bovine) - FBXO25 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). Taurus_UMD|evm.model.AC_000158.1.985 Q86YL5 TDRP_HUMAN 76.216 0.76569 1.29189 TDRP - Testis development-related protein - Homo sapiens (Human) - TDRP gene Contributes to normal sperm motility, but not essential for male fertility. Taurus_UMD|evm.model.AC_000158.1.986 Q96NY7 CLIC6_HUMAN 84.722 0.990654 0.303977 CLIC6 - Chloride intracellular channel protein 6 - Homo sapiens (Human) - CLIC6 gene May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). Taurus_UMD|evm.model.AC_000158.1.987 Q01196 RUNX1_HUMAN 98.661 0.969631 1.01766 RUNX1 - Runt-related transcription factor 1 - Homo sapiens (Human) - RUNX1 gene Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). Taurus_UMD|evm.model.AC_000158.1.991 Q9NVD3 SETD4_HUMAN 81.136 0.995465 1.00227 SETD4 - SET domain-containing protein 4 - Homo sapiens (Human) - SETD4 gene Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response (PubMed:31308046). Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of proinflammatory cytokines IL6 and TNF-alpha (By similarity). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (PubMed:31308046). Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (By similarity). Taurus_UMD|evm.model.AC_000158.1.992 Q3SZD7 CBR1_BOVIN 98.969 0.755906 0.458484 CBR1 - Carbonyl reductase [NADPH] 1 - Bos taurus (Bovine) - CBR1 gene NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity). Taurus_UMD|evm.model.AC_000158.1.993 Q3SZD7 CBR1_BOVIN 95.307 0.992806 1.00361 CBR1 - Carbonyl reductase [NADPH] 1 - Bos taurus (Bovine) - CBR1 gene NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity). Taurus_UMD|evm.model.AC_000158.1.994 Q3SZD7 CBR1_BOVIN 57.513 0.89375 0.577617 CBR1 - Carbonyl reductase [NADPH] 1 - Bos taurus (Bovine) - CBR1 gene NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity). Taurus_UMD|evm.model.AC_000158.1.995 Q3SZD7 CBR1_BOVIN 94.318 0.212195 1.48014 CBR1 - Carbonyl reductase [NADPH] 1 - Bos taurus (Bovine) - CBR1 gene NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity). Taurus_UMD|evm.model.AC_000158.1.996 Q3SZD7 CBR1_BOVIN 80.420 0.663507 0.761733 CBR1 - Carbonyl reductase [NADPH] 1 - Bos taurus (Bovine) - CBR1 gene NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity). Taurus_UMD|evm.model.AC_000158.1.997 Q8K354 CBR3_MOUSE 89.531 0.992806 1.00361 Cbr3 - Carbonyl reductase [NADPH] 3 - Mus musculus (Mouse) - Cbr3 gene Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro). Taurus_UMD|evm.model.AC_000158.1.998 Q9Y3R5 DOP2_HUMAN 84.692 0.999123 0.992602 DOP1B - Protein dopey-2 - Homo sapiens (Human) - DOP1B gene May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. Taurus_UMD|evm.model.AC_000158.1.999 Q14149 MORC3_HUMAN 86.185 0.997856 0.99361 MORC3 - MORC family CW-type zinc finger protein 3 - Homo sapiens (Human) - MORC3 gene Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). Taurus_UMD|evm.model.AC_000158.1.1000 Q13112 CAF1B_HUMAN 84.146 0.994792 1.03041 CHAF1B - Chromatin assembly factor 1 subunit B - Homo sapiens (Human) - CHAF1B gene Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. Taurus_UMD|evm.model.AC_000158.1.1001 Q9Z0S3 CLD14_MOUSE 86.192 0.991597 0.995816 Cldn14 - Claudin-14 - Mus musculus (Mouse) - Cldn14 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Taurus_UMD|evm.model.AC_000158.1.1002 Q14190 SIM2_HUMAN 99.145 0.97479 0.178411 SIM2 - Single-minded homolog 2 - Homo sapiens (Human) - SIM2 gene Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. Taurus_UMD|evm.model.AC_000158.1.1003 Q61079 SIM2_MOUSE 88.916 0.798839 0.78691 Sim2 - Single-minded homolog 2 - Mus musculus (Mouse) - Sim2 gene Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. Taurus_UMD|evm.model.AC_000158.1.1004 P50747 BPL1_HUMAN 74.760 0.828179 1.20248 HLCS - Biotin--protein ligase - Homo sapiens (Human) - HLCS gene Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. Taurus_UMD|evm.model.AC_000158.1.1005 Q924S9 DSCR6_MOUSE 72.881 0.633333 1.18421 Ripply3 - Protein ripply3 - Mus musculus (Mouse) - Ripply3 gene Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives. Taurus_UMD|evm.model.AC_000158.1.1006 P57054 PIGP_HUMAN 94.531 0.984496 0.816456 PIGP - Phosphatidylinositol N-acetylglucosaminyltransferase subunit P - Homo sapiens (Human) - PIGP gene Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Taurus_UMD|evm.model.AC_000158.1.1007 P53804 TTC3_HUMAN 80.249 0.998993 0.980741 TTC3 - E3 ubiquitin-protein ligase TTC3 - Homo sapiens (Human) - TTC3 gene E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323). Taurus_UMD|evm.model.AC_000158.1.1008 O14972 VP26C_HUMAN 93.939 0.993289 1.00337 VPS26C - Vacuolar protein sorting-associated protein 26C - Homo sapiens (Human) - VPS26C gene Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). Taurus_UMD|evm.model.AC_000158.1.1009 Q13627 DYR1A_HUMAN 99.607 0.997382 1.00131 DYRK1A - Dual specificity tyrosine-phosphorylation-regulated kinase 1A - Homo sapiens (Human) - DYRK1A gene Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). Taurus_UMD|evm.model.AC_000158.1.1012 P48051 KCNJ6_HUMAN 99.754 0.995098 0.964539 KCNJ6 - G protein-activated inward rectifier potassium channel 2 - Homo sapiens (Human) - KCNJ6 gene This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Taurus_UMD|evm.model.AC_000158.1.1015 Q91ZV0 MIA2_MOUSE 30.084 0.719512 0.352436 Mia2 - Melanoma inhibitory activity protein 2 precursor - Mus musculus (Mouse) - Mia2 gene Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (By similarity). Thereby, may play a role in cholesterol and triglyceride homeostasis (PubMed:21807889). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (By similarity). Taurus_UMD|evm.model.AC_000158.1.1016 Q99712 KCJ15_HUMAN 97.067 0.994681 1.00267 KCNJ15 - ATP-sensitive inward rectifier potassium channel 15 - Homo sapiens (Human) - KCNJ15 gene Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Taurus_UMD|evm.model.AC_000158.1.1017 P11308 ERG_HUMAN 92.067 0.995726 0.977035 ERG - Transcriptional regulator ERG - Homo sapiens (Human) - ERG gene Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. Taurus_UMD|evm.model.AC_000158.1.1018 A1A4L6 ETS2_BOVIN 97.309 0.993119 0.92766 ETS2 - Protein C-ets-2 - Bos taurus (Bovine) - ETS2 gene Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). Taurus_UMD|evm.model.AC_000158.1.1019 Q91ZV0 MIA2_MOUSE 31.476 0.719512 0.352436 Mia2 - Melanoma inhibitory activity protein 2 precursor - Mus musculus (Mouse) - Mia2 gene Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (By similarity). Thereby, may play a role in cholesterol and triglyceride homeostasis (PubMed:21807889). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (By similarity). Taurus_UMD|evm.model.AC_000158.1.1023 Q99570 PI3R4_HUMAN 96.613 0.998528 1.00074 PIK3R4 - Phosphoinositide 3-kinase regulatory subunit 4 - Homo sapiens (Human) - PIK3R4 gene Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Taurus_UMD|evm.model.AC_000158.1.1024 A6NMZ7 CO6A6_HUMAN 83.164 0.950758 1.04993 COL6A6 - Collagen alpha-6(VI) chain precursor - Homo sapiens (Human) - COL6A6 gene Collagen VI acts as a cell-binding protein. Taurus_UMD|evm.model.AC_000158.1.1025 A8TX70 CO6A5_HUMAN 76.077 0.33035 0.939962 COL6A5 - Collagen alpha-5(VI) chain precursor - Homo sapiens (Human) - COL6A5 gene Collagen VI acts as a cell-binding protein. Taurus_UMD|evm.model.AC_000158.1.1026 A2AX52 CO6A4_MOUSE 63.504 0.927679 0.658727 Col6a4 - Collagen alpha-4(VI) chain precursor - Mus musculus (Mouse) - Col6a4 gene Collagen VI acts as a cell-binding protein. Taurus_UMD|evm.model.AC_000158.1.1027 A2AX52 CO6A4_MOUSE 58.696 0.80531 0.0489389 Col6a4 - Collagen alpha-4(VI) chain precursor - Mus musculus (Mouse) - Col6a4 gene Collagen VI acts as a cell-binding protein. Taurus_UMD|evm.model.AC_000158.1.1028 A0FKG7 CAN7_PIG 97.417 0.997543 1.00123 CAPN7 - Calpain-7 - Sus scrofa (Pig) - CAPN7 gene Calcium-regulated non-lysosomal thiol-protease. Taurus_UMD|evm.model.AC_000158.1.1029 O60239 3BP5_HUMAN 69.565 0.995833 1.05495 SH3BP5 - SH3 domain-binding protein 5 - Homo sapiens (Human) - SH3BP5 gene Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. Taurus_UMD|evm.model.AC_000158.1.1030 Q791B0 UBL5_PSAOB 98.630 0.972973 1.0137 UBL5 - Ubiquitin-like protein 5 - Psammomys obesus (Fat sand rat) - UBL5 gene Taurus_UMD|evm.model.AC_000158.1.1031 Q5RDV8 METL6_PONAB 92.171 0.982456 1.01064 METTL6 - tRNA N(3)-methylcytidine methyltransferase METTL6 - Pongo abelii (Sumatran orangutan) - METTL6 gene S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser). Taurus_UMD|evm.model.AC_000158.1.1032 Q9D4C5 EAF1_MOUSE 92.963 0.740845 1.32463 Eaf1 - ELL-associated factor 1 - Mus musculus (Mouse) - Eaf1 gene Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Taurus_UMD|evm.model.AC_000158.1.1033 O35348 COLQ_MOUSE 87.234 0.790262 1.16849 Colq - Acetylcholinesterase collagenic tail peptide precursor - Mus musculus (Mouse) - Colq gene Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina. Taurus_UMD|evm.model.AC_000158.1.1034 Q9UJ83 HACL1_HUMAN 88.985 0.996564 1.00692 HACL1 - 2-hydroxyacyl-CoA lyase 1 - Homo sapiens (Human) - HACL1 gene Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (PubMed:28289220, PubMed:21708296, PubMed:10468558). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (PubMed:28289220, PubMed:21708296, PubMed:10468558). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity). Taurus_UMD|evm.model.AC_000158.1.1035 A6QQ07 BTD_BOVIN 99.810 0.996198 1.0019 BTD - Biotinidase precursor - Bos taurus (Bovine) - BTD gene Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. Taurus_UMD|evm.model.AC_000158.1.1036 O15084 ANR28_HUMAN 98.372 0.962177 1.02944 ANKRD28 - Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A - Homo sapiens (Human) - ANKRD28 gene Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. Taurus_UMD|evm.model.AC_000158.1.1039 Q8N3T1 GLT15_HUMAN 73.684 0.99686 0.99687 GALNT15 - Polypeptide N-acetylgalactosaminyltransferase 15 - Homo sapiens (Human) - GALNT15 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate. Taurus_UMD|evm.model.AC_000158.1.1040 Q1LZC9 DPH3_BOVIN 100.000 0.525974 1.87805 DPH3 - DPH3 homolog - Bos taurus (Bovine) - DPH3 gene Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). Taurus_UMD|evm.model.AC_000158.1.1041 Q58DM7 OXND1_BOVIN 90.882 0.994135 1.10356 OXNAD1 - Oxidoreductase NAD-binding domain-containing protein 1 precursor - Bos taurus (Bovine) - OXNAD1 gene Taurus_UMD|evm.model.AC_000158.1.1042 Q14699 RFTN1_HUMAN 92.188 0.226619 0.480969 RFTN1 - Raftlin - Homo sapiens (Human) - RFTN1 gene Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). Taurus_UMD|evm.model.AC_000158.1.1043 Q14699 RFTN1_HUMAN 85.965 0.538462 0.179931 RFTN1 - Raftlin - Homo sapiens (Human) - RFTN1 gene Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). Taurus_UMD|evm.model.AC_000158.1.1044 Q9Y2I1 NISCH_HUMAN 43.846 0.445415 0.152261 NISCH - Nischarin - Homo sapiens (Human) - NISCH gene Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures. Taurus_UMD|evm.model.AC_000158.1.1045 Q64368 DAZL_MOUSE 93.165 0.92953 1 Dazl - Deleted in azoospermia-like - Mus musculus (Mouse) - Dazl gene RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts. Taurus_UMD|evm.model.AC_000158.1.1046 Q9UPR0 PLCL2_HUMAN 97.360 0.997972 0.874889 PLCL2 - Inactive phospholipase C-like protein 2 - Homo sapiens (Human) - PLCL2 gene May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. Taurus_UMD|evm.model.AC_000158.1.1047 Q92609 TBCD5_HUMAN 85.840 0.997413 0.972327 TBC1D5 - TBC1 domain family member 5 - Homo sapiens (Human) - TBC1D5 gene May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). Taurus_UMD|evm.model.AC_000158.1.1051 Q60611 SATB1_MOUSE 86.257 0.997257 0.954188 Satb1 - DNA-binding protein SATB1 - Mus musculus (Mouse) - Satb1 gene Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis (By similarity). Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (PubMed:26305964). Taurus_UMD|evm.model.AC_000158.1.1056 O77768 HNRPC_RABIT 68.354 0.604651 0.421569 HNRNPC - Heterogeneous nuclear ribonucleoprotein C - Oryctolagus cuniculus (Rabbit) - HNRNPC gene Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing. Taurus_UMD|evm.model.AC_000158.1.1057 Q96L42 KCNH8_HUMAN 75.455 0.872 0.112918 KCNH8 - Potassium voltage-gated channel subfamily H member 8 - Homo sapiens (Human) - KCNH8 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Taurus_UMD|evm.model.AC_000158.1.1058 Q16778 H2B2E_HUMAN 85.714 0.984252 1.00794 H2BC21 - Histone H2B type 2-E - Homo sapiens (Human) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000159.1.1 P31622 GAG_JSRV 34.146 0.613402 0.316993 gag - Gag polyprotein - Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) - gag gene Matrix protein. Taurus_UMD|evm.model.AC_000159.1.6 O95221 OR5F1_HUMAN 59.659 0.923913 0.585987 OR5F1 - Olfactory receptor 5F1 - Homo sapiens (Human) - OR5F1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000159.1.7 Q1ZZS1 LGSN_CANLF 87.121 0.996219 0.921603 LGSN - Lengsin - Canis lupus familiaris (Dog) - LGSN gene May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity). Taurus_UMD|evm.model.AC_000159.1.8 P83917 CBX1_MOUSE 97.838 0.989247 1.00541 Cbx1 - Chromobox protein homolog 1 - Mus musculus (Mouse) - Cbx1 gene Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Taurus_UMD|evm.model.AC_000159.1.9 Q04671 P_HUMAN 88.372 0.0684039 0.732697 OCA2 - P protein - Homo sapiens (Human) - OCA2 gene Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Taurus_UMD|evm.model.AC_000159.1.10 O95714 HERC2_HUMAN 95.886 0.999587 1.00083 HERC2 - E3 ubiquitin-protein ligase HERC2 - Homo sapiens (Human) - HERC2 gene E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Taurus_UMD|evm.model.AC_000159.1.12 Q8BHK1 NIPA1_MOUSE 98.765 0.993846 1.00619 Nipa1 - Magnesium transporter NIPA1 - Mus musculus (Mouse) - Nipa1 gene Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+). Taurus_UMD|evm.model.AC_000159.1.13 Q3SWX0 NIPA2_BOVIN 100.000 0.99446 1.00278 NIPA2 - Magnesium transporter NIPA2 - Bos taurus (Bovine) - NIPA2 gene Acts as a selective Mg(2+) transporter. Taurus_UMD|evm.model.AC_000159.1.14 Q7TMB8 CYFP1_MOUSE 99.042 0.998405 1.0008 Cyfip1 - Cytoplasmic FMR1-interacting protein 1 - Mus musculus (Mouse) - Cyfip1 gene Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705). Taurus_UMD|evm.model.AC_000159.1.15 Q95K09 GCP5_MACFA 93.931 0.706341 1.41379 TUBGCP5 - Gamma-tubulin complex component 5 - Macaca fascicularis (Crab-eating macaque) - TUBGCP5 gene Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Taurus_UMD|evm.model.AC_000159.1.16 Q3SZB5 CC115_BOVIN 100.000 0.98895 1.00556 CCDC115 - Coiled-coil domain-containing protein 115 - Bos taurus (Bovine) - CCDC115 gene Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity). Taurus_UMD|evm.model.AC_000159.1.17 Q0VD01 IMP4_BOVIN 100.000 0.993151 1.00344 IMP4 - U3 small nucleolar ribonucleoprotein protein IMP4 - Bos taurus (Bovine) - IMP4 gene Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity). Taurus_UMD|evm.model.AC_000159.1.18 Q99952 PTN18_HUMAN 79.130 0.995604 0.98913 PTPN18 - Tyrosine-protein phosphatase non-receptor type 18 - Homo sapiens (Human) - PTPN18 gene Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. Taurus_UMD|evm.model.AC_000159.1.21 Q8N944 AMER3_HUMAN 67.897 0.996287 0.938444 AMER3 - APC membrane recruitment protein 3 - Homo sapiens (Human) - AMER3 gene Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). Taurus_UMD|evm.model.AC_000159.1.22 Q7TNR9 ARHG4_MOUSE 89.876 0.250649 3.9814 Arhgef4 - Rho guanine nucleotide exchange factor 4 - Mus musculus (Mouse) - Arhgef4 gene Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Taurus_UMD|evm.model.AC_000159.1.23 Q0IHC4 F168B_XENLA 88.194 0.85119 0.746667 fam168b - Myelin-associated neurite-outgrowth inhibitor - Xenopus laevis (African clawed frog) - fam168b gene Inhibitor of neuronal axonal outgrowth. Taurus_UMD|evm.model.AC_000159.1.24 Q5R4K6 PKHB2_PONAB 94.144 0.991031 1.0045 PLEKHB2 - Pleckstrin homology domain-containing family B member 2 - Pongo abelii (Sumatran orangutan) - PLEKHB2 gene Involved in retrograde transport of recycling endosomes. Taurus_UMD|evm.model.AC_000159.1.25 P59999 ARPC4_MOUSE 56.287 0.976923 0.77381 Arpc4 - Actin-related protein 2/3 complex subunit 4 - Mus musculus (Mouse) - Arpc4 gene Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Taurus_UMD|evm.model.AC_000159.1.30 O60243 H6ST1_HUMAN 96.594 0.995146 1.00243 HS6ST1 - Heparan-sulfate 6-O-sulfotransferase 1 - Homo sapiens (Human) - HS6ST1 gene 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. Taurus_UMD|evm.model.AC_000159.1.31 Q9NYU2 UGGG1_HUMAN 94.027 0.99871 0.996785 UGGT1 - UDP-glucose:glycoprotein glucosyltransferase 1 precursor - Homo sapiens (Human) - UGGT1 gene Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Taurus_UMD|evm.model.AC_000159.1.32 Q9H0E3 SP130_HUMAN 92.857 0.99817 1.04294 SAP130 - Histone deacetylase complex subunit SAP130 - Homo sapiens (Human) - SAP130 gene Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Taurus_UMD|evm.model.AC_000159.1.33 Q5RDQ3 AMERL_PONAB 99.677 0.993569 1.00323 AMMECR1L - AMMECR1-like protein - Pongo abelii (Sumatran orangutan) - AMMECR1L gene Taurus_UMD|evm.model.AC_000159.1.34 Q9D7M8 RPB4_MOUSE 99.296 0.986014 1.00704 Polr2d - DNA-directed RNA polymerase II subunit RPB4 - Mus musculus (Mouse) - Polr2d gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Taurus_UMD|evm.model.AC_000159.1.35 Q8N9M1 CS047_HUMAN 84.000 0.569767 0.203791 C19orf47 - Uncharacterized protein C19orf47 - Homo sapiens (Human) - C19orf47 gene nucleoplasm, nucleus Taurus_UMD|evm.model.AC_000159.1.36 Q9C0J8 WDR33_HUMAN 98.129 0.998504 1.00075 WDR33 - pre-mRNA 3' end processing protein WDR33 - Homo sapiens (Human) - WDR33 gene Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. Taurus_UMD|evm.model.AC_000159.1.37 Q587I9 SFT2C_HUMAN 80.465 0.990654 0.995349 SFT2D3 - Vesicle transport protein SFT2C - Homo sapiens (Human) - SFT2D3 gene May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Taurus_UMD|evm.model.AC_000159.1.38 Q2KJ33 LIMS2_BOVIN 99.704 0.918256 1.07625 LIMS2 - LIM and senescent cell antigen-like-containing domain protein 2 - Bos taurus (Bovine) - LIMS2 gene Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Taurus_UMD|evm.model.AC_000159.1.39 Q6PIF6 MYO7B_HUMAN 82.961 0.996283 1.01701 MYO7B - Unconventional myosin-VIIb - Homo sapiens (Human) - MYO7B gene Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli (Probable). Taurus_UMD|evm.model.AC_000159.1.40 Q96ST2 IWS1_HUMAN 86.305 0.997642 1.03541 IWS1 - Protein IWS1 homolog - Homo sapiens (Human) - IWS1 gene Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. Taurus_UMD|evm.model.AC_000159.1.41 Q99K70 RRAGC_MOUSE 98.198 0.994012 0.839196 Rragc - Ras-related GTP-binding protein C - Mus musculus (Mouse) - Rragc gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Taurus_UMD|evm.model.AC_000159.1.42 P00745 PROC_BOVIN 99.780 0.859848 1.15789 PROC - Vitamin K-dependent protein C precursor - Bos taurus (Bovine) - PROC gene Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Taurus_UMD|evm.model.AC_000159.1.43 Q9Y2U5 M3K2_HUMAN 97.738 0.995169 1.00323 MAP3K2 - Mitogen-activated protein kinase kinase kinase 2 - Homo sapiens (Human) - MAP3K2 gene Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. Taurus_UMD|evm.model.AC_000159.1.44 Q1RMT1 ERCC3_BOVIN 100.000 0.997446 1.00128 ERCC3 - General transcription and DNA repair factor IIH helicase subunit XPB - Bos taurus (Bovine) - ERCC3 gene ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Taurus_UMD|evm.model.AC_000159.1.45 Q4G0S4 C27C1_HUMAN 85.472 0.889076 1.09779 CYP27C1 - Cytochrome P450 27C1 precursor - Homo sapiens (Human) - CYP27C1 gene A cytochrome P450 monooxygenase that catalyzes the 3,4 desaturation of all-trans-retinol (also called vitamin A1) to all-trans-3,4-didehydroretinol (also called vitamin A2) in the skin. Desaturates with lower efficiency all-trans retinal and all-trans retinoic acid. Forms minor amounts of 3-hydroxy and 4-hydroxy all-trans-retinol derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Taurus_UMD|evm.model.AC_000159.1.46 Q58DQ3 RL6_BOVIN 95.098 0.452915 0.777003 RPL6 - 60S ribosomal protein L6 - Bos taurus (Bovine) - RPL6 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000159.1.47 C0HKE9 H2A1P_MOUSE 97.692 0.984733 1.00769 Hist1h2ap - Histone H2A type 1-P - Mus musculus (Mouse) - Hist1h2ap gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000159.1.48 O00499 BIN1_HUMAN 91.400 0.994614 0.939292 BIN1 - Myc box-dependent-interacting protein 1 - Homo sapiens (Human) - BIN1 gene Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863). Taurus_UMD|evm.model.AC_000159.1.49 Q8IYP2 PRS58_HUMAN 40.758 0.793893 1.08714 PRSS58 - Serine protease 58 precursor - Homo sapiens (Human) - PRSS58 gene secretory granule Taurus_UMD|evm.model.AC_000159.1.50 Q13506 NAB1_HUMAN 95.893 0.822335 1.21355 NAB1 - NGFI-A-binding protein 1 - Homo sapiens (Human) - NAB1 gene Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Taurus_UMD|evm.model.AC_000159.1.51 A6NFY4 NEMP2_HUMAN 66.227 0.882629 1.02158 NEMP2 - Nuclear envelope integral membrane protein 2 precursor - Homo sapiens (Human) - NEMP2 gene nuclear envelope Taurus_UMD|evm.model.AC_000159.1.52 A1DWM3 MFSD6_PIG 90.274 0.9975 1.00251 MFSD6 - Major facilitator superfamily domain-containing protein 6 - Sus scrofa (Pig) - MFSD6 gene membrane, plasma membrane, antigen processing and presentation of exogenous peptide antigen via MHC class I Taurus_UMD|evm.model.AC_000159.1.53 P21327 INPP_BOVIN 100.000 0.995012 1.0025 INPP1 - Inositol polyphosphate 1-phosphatase - Bos taurus (Bovine) - INPP1 gene inositol-1,4-bisphosphate 1-phosphatase activity, inositol phosphate dephosphorylation Taurus_UMD|evm.model.AC_000159.1.54 Q2HJ73 HIBCH_BOVIN 100.000 0.917647 0.880829 HIBCH - 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial precursor - Bos taurus (Bovine) - HIBCH gene Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity). Taurus_UMD|evm.model.AC_000159.1.55 Q3SZY8 SMAKA_BOVIN 100.000 0.979167 1.01053 Small membrane A-kinase anchor protein - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000159.1.56 O18836 GDF8_BOVIN 100.000 0.994681 1.00267 MSTN - Growth/differentiation factor 8 precursor - Bos taurus (Bovine) - MSTN gene Acts specifically as a negative regulator of skeletal muscle growth. Taurus_UMD|evm.model.AC_000159.1.59 P54277 PMS1_HUMAN 83.387 0.891762 1.12017 PMS1 - PMS1 protein homolog 1 - Homo sapiens (Human) - PMS1 gene Probably involved in the repair of mismatches in DNA. Taurus_UMD|evm.model.AC_000159.1.60 Q29RQ9 ORML1_BOVIN 100.000 0.987013 1.00654 ORMDL1 - ORM1-like protein 1 - Bos taurus (Bovine) - ORMDL1 gene Negative regulator of sphingolipid synthesis. Taurus_UMD|evm.model.AC_000159.1.61 Q9H4B0 OSGP2_HUMAN 88.164 0.995181 1.00242 OSGEPL1 - Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial precursor - Homo sapiens (Human) - OSGEPL1 gene Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. Taurus_UMD|evm.model.AC_000159.1.62 Q7Z5J8 ANKAR_HUMAN 88.105 0.998617 1.00837 ANKAR - Ankyrin and armadillo repeat-containing protein - Homo sapiens (Human) - ANKAR gene Taurus_UMD|evm.model.AC_000159.1.63 Q0V8E4 ASND1_BOVIN 98.594 0.99688 1.00156 ASNSD1 - Asparagine synthetase domain-containing protein 1 - Bos taurus (Bovine) - ASNSD1 gene Taurus_UMD|evm.model.AC_000159.1.64 L0R819 ASURF_HUMAN 83.333 0.979381 1.01042 ASDURF - ASNSD1 upstream open reading frame protein - Homo sapiens (Human) - ASDURF gene Taurus_UMD|evm.model.AC_000159.1.65 Q9NP59 S40A1_HUMAN 89.739 0.996522 1.00701 SLC40A1 - Solute carrier family 40 member 1 - Homo sapiens (Human) - SLC40A1 gene May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Taurus_UMD|evm.model.AC_000159.1.66 Q8IWA0 WDR75_HUMAN 91.576 0.997596 1.00241 WDR75 - WD repeat-containing protein 75 - Homo sapiens (Human) - WDR75 gene Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Taurus_UMD|evm.model.AC_000159.1.67 P05997 CO5A2_HUMAN 88.843 0.990476 0.910607 COL5A2 - Collagen alpha-2(V) chain precursor - Homo sapiens (Human) - COL5A2 gene Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). Taurus_UMD|evm.model.AC_000159.1.68 P08121 CO3A1_MOUSE 75.401 0.857032 0.879098 Col3a1 - Collagen alpha-1(III) chain precursor - Mus musculus (Mouse) - Col3a1 gene Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. Taurus_UMD|evm.model.AC_000159.1.69 Q9UBP9 GULP1_HUMAN 96.053 0.993443 1.00329 GULP1 - PTB domain-containing engulfment adapter protein 1 - Homo sapiens (Human) - GULP1 gene May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. Taurus_UMD|evm.model.AC_000159.1.71 P10646 TFPI1_HUMAN 69.103 0.986622 0.983553 TFPI - Tissue factor pathway inhibitor precursor - Homo sapiens (Human) - TFPI gene Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. Taurus_UMD|evm.model.AC_000159.1.72 A6QP74 CALRL_BOVIN 92.593 0.994475 0.78355 CALCRL - Calcitonin gene-related peptide type 1 receptor precursor - Bos taurus (Bovine) - CALCRL gene Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Taurus_UMD|evm.model.AC_000159.1.73 Q8NEG5 ZSWM2_HUMAN 76.378 0.99685 1.00316 ZSWIM2 - E3 ubiquitin-protein ligase ZSWIM2 - Homo sapiens (Human) - ZSWIM2 gene E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes. Taurus_UMD|evm.model.AC_000159.1.74 Q6P995 F171B_HUMAN 92.513 0.97903 0.923729 FAM171B - Protein FAM171B precursor - Homo sapiens (Human) - FAM171B gene Taurus_UMD|evm.model.AC_000159.1.75 P80746 ITAV_BOVIN 99.771 0.891837 0.935115 ITGAV - Integrin alpha-V precursor - Bos taurus (Bovine) - ITGAV gene The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG (By similarity). Taurus_UMD|evm.model.AC_000159.1.76 Q1RMM1 ZC3HF_BOVIN 100.000 0.995316 1.00235 ZC3H15 - Zinc finger CCCH domain-containing protein 15 - Bos taurus (Bovine) - ZC3H15 gene Protects DRG1 from proteolytic degradation. Taurus_UMD|evm.model.AC_000159.1.78 P14381 YTX2_XENLA 34.066 0.371901 0.185015 Transposon TX1 uncharacterized 149 kDa protein - Xenopus laevis (African clawed frog) Taurus_UMD|evm.model.AC_000159.1.80 Q5CZC0 FSIP2_HUMAN 67.010 0.999708 0.991892 FSIP2 - Fibrous sheath-interacting protein 2 - Homo sapiens (Human) - FSIP2 gene Plays a role in spermatogenesis. Taurus_UMD|evm.model.AC_000159.1.81 Q9MYN5 CDKN3_PIG 52.985 0.980769 0.490566 CDKN3 - Cyclin-dependent kinase inhibitor 3 - Sus scrofa (Pig) - CDKN3 gene May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000159.1.82 Q9NX94 WBP1L_HUMAN 74.257 0.935374 0.859649 WBP1L - WW domain binding protein 1-like - Homo sapiens (Human) - WBP1L gene Taurus_UMD|evm.model.AC_000159.1.83 Q7Z570 Z804A_HUMAN 75.620 0.99784 0.765922 ZNF804A - Zinc finger protein 804A - Homo sapiens (Human) - ZNF804A gene cytoplasm, dendritic microtubule, dendritic shaft, dendritic spine, growth cone, neuronal cell body, nucleus, plasma membrane, postsynapse, positive regulation of gene expression Taurus_UMD|evm.model.AC_000159.1.84 Q7Z570 Z804A_HUMAN 86.486 0.978723 0.1555 ZNF804A - Zinc finger protein 804A - Homo sapiens (Human) - ZNF804A gene cytoplasm, dendritic microtubule, dendritic shaft, dendritic spine, growth cone, neuronal cell body, nucleus, plasma membrane, postsynapse, positive regulation of gene expression Taurus_UMD|evm.model.AC_000159.1.85 Q63486 RRAGA_RAT 97.125 0.993631 1.00319 Rraga - Ras-related GTP-binding protein A - Rattus norvegicus (Rat) - Rraga gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. Taurus_UMD|evm.model.AC_000159.1.86 O02751 CFDP2_BOVIN 76.271 0.112403 0.871622 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000159.1.87 Q9JHG1 PIGP_MOUSE 87.379 0.910714 0.848485 Pigp - Phosphatidylinositol N-acetylglucosaminyltransferase subunit P - Mus musculus (Mouse) - Pigp gene Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Taurus_UMD|evm.model.AC_000159.1.88 Q8NFH5 NUP35_HUMAN 96.330 0.993902 1.00613 NUP35 - Nucleoporin NUP35 - Homo sapiens (Human) - NUP35 gene Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. Taurus_UMD|evm.model.AC_000159.1.89 Q8WTR2 DUS19_HUMAN 91.589 0.934211 1.05069 DUSP19 - Dual specificity protein phosphatase 19 - Homo sapiens (Human) - DUSP19 gene Has a dual specificity toward Ser/Thr and Tyr-containing proteins. Taurus_UMD|evm.model.AC_000159.1.90 Q9Y2A7 NCKP1_HUMAN 96.196 0.983486 0.966312 NCKAP1 - Nck-associated protein 1 - Homo sapiens (Human) - NCKAP1 gene Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. Taurus_UMD|evm.model.AC_000159.1.91 Q95117 SFRP3_BOVIN 95.077 0.993548 0.953846 FRZB - Secreted frizzled-related protein 3 precursor - Bos taurus (Bovine) - FRZB gene Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. Taurus_UMD|evm.model.AC_000159.1.92 Q8IXB1 DJC10_HUMAN 91.551 0.997481 1.00126 DNAJC10 - DnaJ homolog subfamily C member 10 precursor - Homo sapiens (Human) - DNAJC10 gene Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. Taurus_UMD|evm.model.AC_000159.1.93 P14100 PDE1A_BOVIN 98.812 0.978641 0.971698 PDE1A - Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A - Bos taurus (Bovine) - PDE1A gene Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP (By similarity). Taurus_UMD|evm.model.AC_000159.1.94 P28290 ITPI2_HUMAN 85.952 0.998413 1.00079 ITPRID2 - Protein ITPRID2 - Homo sapiens (Human) - ITPRID2 gene cytosol, nucleoplasm, plasma membrane, actin filament binding Taurus_UMD|evm.model.AC_000159.1.96 Q13562 NDF1_HUMAN 98.034 0.994398 1.00281 NEUROD1 - Neurogenic differentiation factor 1 - Homo sapiens (Human) - NEUROD1 gene Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). Taurus_UMD|evm.model.AC_000159.1.97 Q49MI3 CERKL_HUMAN 81.867 0.97786 0.971326 CERKL - Ceramide kinase-like protein - Homo sapiens (Human) - CERKL gene Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. Taurus_UMD|evm.model.AC_000159.1.98 P13612 ITA4_HUMAN 85.853 0.997099 1.00194 ITGA4 - Integrin alpha-4 precursor - Homo sapiens (Human) - ITGA4 gene Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). Taurus_UMD|evm.model.AC_000159.1.101 O02751 CFDP2_BOVIN 80.729 0.989637 0.326014 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000159.1.103 Q9HCG8 CWC22_HUMAN 90.419 0.99667 0.992291 CWC22 - Pre-mRNA-splicing factor CWC22 homolog - Homo sapiens (Human) - CWC22 gene Required for pre-mRNA splicing as component of the spliceosome (PubMed:12226669, PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Taurus_UMD|evm.model.AC_000159.1.105 Q569K4 Z385B_HUMAN 97.059 0.468531 0.303609 ZNF385B - Zinc finger protein 385B - Homo sapiens (Human) - ZNF385B gene May play a role in p53/TP53-mediated apoptosis. Taurus_UMD|evm.model.AC_000159.1.106 B2KI64 PI4KB_RHIFE 88.889 0.98 0.122549 PI4KB - Phosphatidylinositol 4-kinase beta - Rhinolophus ferrumequinum (Greater horseshoe bat) - PI4KB gene Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity). Taurus_UMD|evm.model.AC_000159.1.107 B1MTG7 PI4KB_PLEMO 74.304 0.938389 0.517157 PI4KB - Phosphatidylinositol 4-kinase beta - Plecturocebus moloch (Dusky titi monkey) - PI4KB gene Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity). Taurus_UMD|evm.model.AC_000159.1.108 Q569K4 Z385B_HUMAN 95.584 0.941176 0.866242 ZNF385B - Zinc finger protein 385B - Homo sapiens (Human) - ZNF385B gene May play a role in p53/TP53-mediated apoptosis. Taurus_UMD|evm.model.AC_000159.1.109 Q86VW0 SESD1_HUMAN 98.309 0.956019 0.62069 SESTD1 - SEC14 domain and spectrin repeat-containing protein 1 - Homo sapiens (Human) - SESTD1 gene May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1. Taurus_UMD|evm.model.AC_000159.1.110 Q6ZP82 CC141_HUMAN 79.834 0.941792 1.05448 CCDC141 - Coiled-coil domain-containing protein 141 - Homo sapiens (Human) - CCDC141 gene Plays a critical role in radial migration and centrosomal function. Taurus_UMD|evm.model.AC_000159.1.111 Q8WZ42 TITIN_HUMAN 94.116 0.654935 1.00169 TTN - Titin - Homo sapiens (Human) - TTN gene Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. Taurus_UMD|evm.model.AC_000159.1.112 Q9HB20 PKHA3_HUMAN 95.333 0.993355 1.00333 PLEKHA3 - Pleckstrin homology domain-containing family A member 3 - Homo sapiens (Human) - PLEKHA3 gene Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). Taurus_UMD|evm.model.AC_000159.1.113 Q9Y680 FKBP7_HUMAN 90.863 0.697509 1.26577 FKBP7 - Peptidyl-prolyl cis-trans isomerase FKBP7 precursor - Homo sapiens (Human) - FKBP7 gene PPIases accelerate the folding of proteins during protein synthesis. Taurus_UMD|evm.model.AC_000159.1.114 Q0ZLH3 PJVK_HUMAN 98.295 0.994334 1.00284 PJVK - Pejvakin - Homo sapiens (Human) - PJVK gene Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation. Taurus_UMD|evm.model.AC_000159.1.115 Q2HJ92 PRKRA_BOVIN 100.000 0.993631 1.00319 PRKRA - Interferon-inducible double-stranded RNA-dependent protein kinase activator A - Bos taurus (Bovine) - PRKRA gene Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000159.1.116 Q9BZF3 OSBL6_HUMAN 95.396 0.997847 0.994647 OSBPL6 - Oxysterol-binding protein-related protein 6 - Homo sapiens (Human) - OSBPL6 gene Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Taurus_UMD|evm.model.AC_000159.1.118 Q8IUH3 RBM45_HUMAN 95.588 0.995789 0.997899 RBM45 - RNA-binding protein 45 - Homo sapiens (Human) - RBM45 gene RNA-binding protein with binding specificity for poly(C). May play an important role in neural development. Taurus_UMD|evm.model.AC_000159.1.119 Q3SZT9 CYC2_BOVIN 100.000 0.981132 1.00952 CYCT - Cytochrome c 2 - Bos taurus (Bovine) - CYCT gene Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). Taurus_UMD|evm.model.AC_000159.1.120 Q9HCR9 PDE11_HUMAN 87.171 0.907692 0.348339 PDE11A - Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Homo sapiens (Human) - PDE11A gene Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. Taurus_UMD|evm.model.AC_000159.1.121 Q5R893 H2B1_PONAB 94.030 0.970588 0.539683 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000159.1.122 Q1KKS3 PDE11_TAKRU 84.906 0.329114 0.174972 pde11a - Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Takifugu rubripes (Japanese pufferfish) - pde11a gene Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (By similarity). Taurus_UMD|evm.model.AC_000159.1.124 Q9HCR9 PDE11_HUMAN 96.957 0.938272 0.26045 PDE11A - Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Homo sapiens (Human) - PDE11A gene Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. Taurus_UMD|evm.model.AC_000159.1.125 Q9HCR9 PDE11_HUMAN 85.503 0.977419 0.332262 PDE11A - Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Homo sapiens (Human) - PDE11A gene Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. Taurus_UMD|evm.model.AC_000159.1.126 A2VE45 TT30A_BOVIN 100.000 0.996992 1.00151 TTC30A - Tetratricopeptide repeat protein 30A - Bos taurus (Bovine) - TTC30A gene Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. Taurus_UMD|evm.model.AC_000159.1.127 A6H739 TT30B_BOVIN 100.000 0.996992 1.00151 TTC30B - Tetratricopeptide repeat protein 30B - Bos taurus (Bovine) - TTC30B gene Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. Taurus_UMD|evm.model.AC_000159.1.128 O00116 ADAS_HUMAN 94.391 0.907324 1.01672 AGPS - Alkyldihydroxyacetonephosphate synthase, peroxisomal precursor - Homo sapiens (Human) - AGPS gene Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis. Taurus_UMD|evm.model.AC_000159.1.129 Q78EG7 TP4A1_RAT 78.689 0.491525 0.682081 Ptp4a1 - Protein tyrosine phosphatase type IVA 1 precursor - Rattus norvegicus (Rat) - Ptp4a1 gene Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). Taurus_UMD|evm.model.AC_000159.1.130 Q5NUA6 NF2L2_BOVIN 99.671 0.996711 1.00165 NFE2L2 - Nuclear factor erythroid 2-related factor 2 - Bos taurus (Bovine) - NFE2L2 gene Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles. In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex. In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes. The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (By similarity). Taurus_UMD|evm.model.AC_000159.1.131 Q6URK4 ROA3_RAT 99.440 0.99162 0.944591 Hnrnpa3 - Heterogeneous nuclear ribonucleoprotein A3 - Rattus norvegicus (Rat) - Hnrnpa3 gene Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000159.1.134 Q2L969 MTX2_PIG 97.004 0.992453 0.992509 MTX2 - Metaxin-2 - Sus scrofa (Pig) - MTX2 gene Involved in transport of proteins into the mitochondrion. Taurus_UMD|evm.model.AC_000159.1.135 Q9GZZ0 HXD1_HUMAN 80.488 0.993808 0.984756 HOXD1 - Homeobox protein Hox-D1 - Homo sapiens (Human) - HOXD1 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Taurus_UMD|evm.model.AC_000159.1.136 P31249 HXD3_HUMAN 96.313 0.995402 1.00694 HOXD3 - Homeobox protein Hox-D3 - Homo sapiens (Human) - HOXD3 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000159.1.137 A2T6X6 HXD4_PANTR 92.636 0.992278 1.01569 HOXD4 - Homeobox protein Hox-D4 - Pan troglodytes (Chimpanzee) - HOXD4 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000159.1.138 P13378 HXD8_HUMAN 89.041 0.992806 0.958621 HOXD8 - Homeobox protein Hox-D8 - Homo sapiens (Human) - HOXD8 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000159.1.139 P28357 HXD9_MOUSE 87.791 0.994203 1.0177 Hoxd9 - Homeobox protein Hox-D9 - Mus musculus (Mouse) - Hoxd9 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000159.1.140 P28358 HXD10_HUMAN 99.412 0.994135 1.00294 HOXD10 - Homeobox protein Hox-D10 - Homo sapiens (Human) - HOXD10 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000159.1.141 P31277 HXD11_HUMAN 92.330 0.994083 1 HOXD11 - Homeobox protein Hox-D11 - Homo sapiens (Human) - HOXD11 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000159.1.142 Q5EU40 HXD12_CARPS 91.852 0.867314 1.14444 HOXD12 - Homeobox protein Hox-D12 - Carollia perspicillata (Seba's short-tailed bat) - HOXD12 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000159.1.143 Q5EU41 HXD13_CARPS 98.697 0.516892 1.77778 HOXD13 - Homeobox protein Hox-D13 - Carollia perspicillata (Seba's short-tailed bat) - HOXD13 gene Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000159.1.144 P62268 RS23_RAT 90.909 0.983607 0.853147 Rps23 - 40S ribosomal protein S23 - Rattus norvegicus (Rat) - Rps23 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy. Taurus_UMD|evm.model.AC_000159.1.145 Q9C0E8 LNP_HUMAN 79.439 0.992537 0.939252 LNPK - Endoplasmic reticulum junction formation protein lunapark - Homo sapiens (Human) - LNPK gene Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983). Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb development (By similarity). Is involved in central nervous system development (PubMed:30032983). Taurus_UMD|evm.model.AC_000159.1.146 Q32L31 HMGB3_BOVIN 98.333 0.98895 0.905 HMGB3 - High mobility group protein B3 - Bos taurus (Bovine) - HMGB3 gene Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). Taurus_UMD|evm.model.AC_000159.1.150 Q3ZC75 AT5G3_BOVIN 100.000 0.843373 1.1773 ATP5MC3 - ATP synthase F(0) complex subunit C3, mitochondrial precursor - Bos taurus (Bovine) - ATP5MC3 gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element. Taurus_UMD|evm.model.AC_000159.1.151 P15336 ATF2_HUMAN 99.010 0.996047 1.00198 ATF2 - Cyclic AMP-dependent transcription factor ATF-2 - Homo sapiens (Human) - ATF2 gene Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. Taurus_UMD|evm.model.AC_000159.1.152 Q17QN0 CHIN_BOVIN 99.639 0.6 1.37725 CHN1 - N-chimaerin - Bos taurus (Bovine) - CHN1 gene GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance (By similarity). Taurus_UMD|evm.model.AC_000159.1.153 P02709 ACHA_BOVIN 100.000 0.995633 1.00219 CHRNA1 - Acetylcholine receptor subunit alpha precursor - Bos taurus (Bovine) - CHRNA1 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Taurus_UMD|evm.model.AC_000159.1.155 O43516 WIPF1_HUMAN 86.250 0.791667 1.00199 WIPF1 - WAS/WASL-interacting protein family member 1 - Homo sapiens (Human) - WIPF1 gene Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. Taurus_UMD|evm.model.AC_000159.1.156 Q7Z3F1 GP155_HUMAN 93.088 0.993103 1 GPR155 - Integral membrane protein GPR155 - Homo sapiens (Human) - GPR155 gene extracellular exosome, cognition Taurus_UMD|evm.model.AC_000159.1.157 Q17QS0 SCRN3_BOVIN 99.763 0.995272 1.00237 SCRN3 - Secernin-3 - Bos taurus (Bovine) - SCRN3 gene Taurus_UMD|evm.model.AC_000159.1.158 Q5ZI03 CIR1_CHICK 81.034 0.554945 0.791304 CIR1 - Corepressor interacting with RBPJ 1 - Gallus gallus (Chicken) - CIR1 gene May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as corepressor. Recruits repressors to the histone deacetylase complex (HDAC) (By similarity). Taurus_UMD|evm.model.AC_000159.1.159 P0CG40 SP9_HUMAN 99.356 0.99569 0.958678 SP9 - Transcription factor Sp9 - Homo sapiens (Human) - SP9 gene Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity). Taurus_UMD|evm.model.AC_000159.1.160 Q2HJ33 OLA1_BOVIN 100.000 0.710432 1.40404 OLA1 - Obg-like ATPase 1 - Bos taurus (Bovine) - OLA1 gene Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. Taurus_UMD|evm.model.AC_000159.1.161 P52505 ACPM_BOVIN 75.817 0.593458 1.37179 NDUFAB1 - Acyl carrier protein, mitochondrial precursor - Bos taurus (Bovine) - NDUFAB1 gene Carrier of the growing fatty acid chain in fatty acid biosynthesis (PubMed:1907568). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:1907568, PubMed:10852722, PubMed:18721790). Taurus_UMD|evm.model.AC_000159.1.162 Q02447 SP3_HUMAN 98.110 0.994211 0.884763 SP3 - Transcription factor Sp3 - Homo sapiens (Human) - SP3 gene Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. Taurus_UMD|evm.model.AC_000159.1.163 Q791B0 UBL5_PSAOB 98.630 0.648649 1.52055 UBL5 - Ubiquitin-like protein 5 - Psammomys obesus (Fat sand rat) - UBL5 gene Taurus_UMD|evm.model.AC_000159.1.164 Q32PH1 CDCA7_BOVIN 100.000 0.666667 1.29947 CDCA7 - Cell division cycle-associated protein 7 - Bos taurus (Bovine) - CDCA7 gene Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator (By similarity). Taurus_UMD|evm.model.AC_000159.1.165 Q9NYL2 M3K20_HUMAN 98.187 0.308123 1.33875 MAP3K20 - Mitogen-activated protein kinase kinase kinase 20 - Homo sapiens (Human) - MAP3K20 gene Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636). Taurus_UMD|evm.model.AC_000159.1.166 Q8WZA2 RPGF4_HUMAN 94.848 0.942157 1.0089 RAPGEF4 - Rap guanine nucleotide exchange factor 4 - Homo sapiens (Human) - RAPGEF4 gene Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity). Taurus_UMD|evm.model.AC_000159.1.167 Q15118 PDK1_HUMAN 93.836 0.995444 1.00688 PDK1 - [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial precursor - Homo sapiens (Human) - PDK1 gene Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. Taurus_UMD|evm.model.AC_000159.1.168 Q61739 ITA6_MOUSE 91.751 0.998168 1.00092 Itga6 - Integrin alpha-6 precursor - Mus musculus (Mouse) - Itga6 gene Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (PubMed:8081870). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (PubMed:10634791). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (PubMed:8673141). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (By similarity). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity). Taurus_UMD|evm.model.AC_000159.1.173 Q07687 DLX2_HUMAN 93.393 0.993976 1.0122 DLX2 - Homeobox protein DLX-2 - Homo sapiens (Human) - DLX2 gene Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. Taurus_UMD|evm.model.AC_000159.1.174 P56177 DLX1_HUMAN 98.824 0.992188 1.00392 DLX1 - Homeobox protein DLX-1 - Homo sapiens (Human) - DLX1 gene Plays a role as a transcriptional activator or repressor (PubMed:14671321). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (PubMed:14671321). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity). Taurus_UMD|evm.model.AC_000159.1.175 Q6UB28 MAP12_HUMAN 94.925 0.994048 1.00299 METAP1D - Methionine aminopeptidase 1D, mitochondrial precursor - Homo sapiens (Human) - METAP1D gene Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis. Taurus_UMD|evm.model.AC_000159.1.176 O14929 HAT1_HUMAN 98.329 0.995238 1.00239 HAT1 - Histone acetyltransferase type B catalytic subunit - Homo sapiens (Human) - HAT1 gene Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:31278053, PubMed:20953179, PubMed:23653357, PubMed:32081014). Coordinates histone production and acetylation via H4 promoter binding (PubMed:31278053). Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac) (PubMed:22615379, PubMed:11585814). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression (PubMed:31278053). Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23653357). In addition, acetylates other substrates such as chromatin-related proteins (PubMed:32081014). Acetylates also RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (PubMed:31812350). Taurus_UMD|evm.model.AC_000159.1.177 Q5RBC8 CMC1_PONAB 97.337 0.995562 0.99705 SLC25A12 - Calcium-binding mitochondrial carrier protein Aralar1 - Pongo abelii (Sumatran orangutan) - SLC25A12 gene Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. Taurus_UMD|evm.model.AC_000159.1.178 Q0III3 DC1I2_BOVIN 99.826 0.930308 1.00817 DYNC1I2 - Cytoplasmic dynein 1 intermediate chain 2 - Bos taurus (Bovine) - DYNC1I2 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. Taurus_UMD|evm.model.AC_000159.1.179 P62856 RS26_RAT 92.929 0.98 0.869565 Rps26 - 40S ribosomal protein S26 - Rattus norvegicus (Rat) - Rps26 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, mRNA binding, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000159.1.180 P70202 LXN_MOUSE 84.071 0.982456 0.513514 Lxn - Latexin - Mus musculus (Mouse) - Lxn gene Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4 (By similarity). May play a role in inflammation. Taurus_UMD|evm.model.AC_000159.1.181 Q53TN4 CYBR1_HUMAN 81.818 0.993007 1 CYBRD1 - Plasma membrane ascorbate-dependent reductase CYBRD1 - Homo sapiens (Human) - CYBRD1 gene Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) (PubMed:30272000). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes (PubMed:30272000). It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood (PubMed:17068337). May also act as a ferrireductase in airway epithelial cells (Probable). May also function as a cupric transmembrane reductase (By similarity). Taurus_UMD|evm.model.AC_000159.1.182 Q5H9S7 DCA17_HUMAN 86.486 0.975 1 DCAF17 - DDB1- and CUL4-associated factor 17 - Homo sapiens (Human) - DCAF17 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Taurus_UMD|evm.model.AC_000159.1.183 Q9H825 METL8_HUMAN 78.082 0.624642 1.19931 METTL8 - mRNA N(3)-methylcytidine methyltransferase METTL8 - Homo sapiens (Human) - METTL8 gene S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of mRNAs. Taurus_UMD|evm.model.AC_000159.1.185 Q9UKI8 TLK1_HUMAN 99.347 0.997392 1.00131 TLK1 - Serine/threonine-protein kinase tousled-like 1 - Homo sapiens (Human) - TLK1 gene Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. Taurus_UMD|evm.model.AC_000159.1.187 Q9H8Y8 GORS2_HUMAN 89.011 0.995614 1.00885 GORASP2 - Golgi reassembly-stacking protein 2 - Homo sapiens (Human) - GORASP2 gene Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). Taurus_UMD|evm.model.AC_000159.1.188 Q0VCA1 DCE1_BOVIN 100.000 0.996639 1.00168 GAD1 - Glutamate decarboxylase 1 - Bos taurus (Bovine) - GAD1 gene Catalyzes the production of GABA. Taurus_UMD|evm.model.AC_000159.1.189 A6QQ66 ERIC2_BOVIN 100.000 0.986014 1.00704 ERICH2 - Glutamate-rich protein 2 - Bos taurus (Bovine) - ERICH2 gene Taurus_UMD|evm.model.AC_000159.1.190 Q6BEB4 SP5_HUMAN 87.186 0.994429 0.90201 SP5 - Transcription factor Sp5 - Homo sapiens (Human) - SP5 gene Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity). Taurus_UMD|evm.model.AC_000159.1.191 Q8WXR4 MYO3B_HUMAN 88.738 0.998163 0.812081 MYO3B - Myosin-IIIb - Homo sapiens (Human) - MYO3B gene Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments. Taurus_UMD|evm.model.AC_000159.1.192 Q8WXR4 MYO3B_HUMAN 84.337 0.769231 0.213274 MYO3B - Myosin-IIIb - Homo sapiens (Human) - MYO3B gene Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments. Taurus_UMD|evm.model.AC_000159.1.193 Q6ZT12 UBR3_HUMAN 94.579 0.998925 0.985169 UBR3 - E3 ubiquitin-protein ligase UBR3 - Homo sapiens (Human) - UBR3 gene E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610). Taurus_UMD|evm.model.AC_000159.1.194 Q9NRN9 METL5_HUMAN 93.333 0.990521 1.00957 METTL5 - rRNA N6-adenosine-methyltransferase METTL5 - Homo sapiens (Human) - METTL5 gene Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:31328227, PubMed:32217665). N6-methylation of adenine(1832) in 18S rRNA is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation (By similarity). Taurus_UMD|evm.model.AC_000159.1.195 P10881 LA_BOVIN 100.000 0.995062 1.00248 SSB - Lupus La protein homolog - Bos taurus (Bovine) - SSB gene Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. Taurus_UMD|evm.model.AC_000159.1.196 Q8NBE8 KLH23_HUMAN 98.387 0.996422 1.00179 KLHL23 - Kelch-like protein 23 - Homo sapiens (Human) - KLHL23 gene Taurus_UMD|evm.model.AC_000159.1.197 Q2KI06 PHOP2_BOVIN 100.000 0.991736 1.00415 PHOSPHO2 - Pyridoxal phosphate phosphatase PHOSPHO2 - Bos taurus (Bovine) - PHOSPHO2 gene Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate (By similarity). Taurus_UMD|evm.model.AC_000159.1.198 Q0VFZ6 CC173_HUMAN 87.203 0.99635 0.992754 CCDC173 - Coiled-coil domain-containing protein 173 - Homo sapiens (Human) - CCDC173 gene Taurus_UMD|evm.model.AC_000159.1.199 Q13427 PPIG_HUMAN 94.430 0.997347 1 PPIG - Peptidyl-prolyl cis-trans isomerase G - Homo sapiens (Human) - PPIG gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. Taurus_UMD|evm.model.AC_000159.1.200 Q53R41 FAKD1_HUMAN 76.082 0.997599 0.983471 FASTKD1 - FAST kinase domain-containing protein 1, mitochondrial precursor - Homo sapiens (Human) - FASTKD1 gene Involved in the down-regulation of mitochondrial MT-ND3 mRNA levels which leads to decreased respiratory complex I abundance and activity. Taurus_UMD|evm.model.AC_000159.1.201 O60662 KLH41_HUMAN 97.525 0.658324 1.5165 KLHL41 - Kelch-like protein 41 - Homo sapiens (Human) - KLHL41 gene Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. Taurus_UMD|evm.model.AC_000159.1.203 C0HL13 LRP2_PIG 76.503 0.99957 0.99957 LRP2 - Low-density lipoprotein receptor-related protein 2 precursor - Sus scrofa (Pig) - LRP2 gene Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals (By similarity). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (By similarity). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (By similarity). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (By similarity). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (By similarity). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (By similarity). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (By similarity). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (By similarity). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (By similarity). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (By similarity). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensis 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (PubMed:9228033). Required for embryonic heart development (By similarity). Required for normal hearing, possibly through interaction with estrogen in the inner ear (By similarity). Taurus_UMD|evm.model.AC_000159.1.204 Q8HYR6 DHRS9_BOVIN 100.000 0.99375 1.00313 DHRS9 - Dehydrogenase/reductase SDR family member 9 precursor - Bos taurus (Bovine) - DHRS9 gene 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. Plays also a role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH. Taurus_UMD|evm.model.AC_000159.1.205 B8K1W2 ABCBB_CANLF 89.208 0.998492 1.00075 Abcb11e - Bile salt export pump - Canis lupus familiaris (Dog) - Abcb11e gene Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates to hepatic bile acids homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:18985798). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (By similarity). Taurus_UMD|evm.model.AC_000159.1.206 Q9NQR9 G6PC2_HUMAN 89.518 0.988764 1.00282 G6PC2 - Glucose-6-phosphatase 2 - Homo sapiens (Human) - G6PC2 gene May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity). Taurus_UMD|evm.model.AC_000159.1.207 Q3ZBK3 SPC25_BOVIN 100.000 0.991189 1.00442 SPC25 - Kinetochore protein Spc25 - Bos taurus (Bovine) - SPC25 gene Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Taurus_UMD|evm.model.AC_000159.1.208 Q2KJB5 NOSTN_BOVIN 99.605 0.996055 1.00396 NOSTRIN - Nostrin - Bos taurus (Bovine) - NOSTRIN gene Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. Taurus_UMD|evm.model.AC_000159.1.209 Q6ZMG9 CERS6_HUMAN 91.582 0.994911 1.02344 CERS6 - Ceramide synthase 6 - Homo sapiens (Human) - CERS6 gene Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor (PubMed:17977534, PubMed:17609214, PubMed:23530041, PubMed:26887952, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity). Taurus_UMD|evm.model.AC_000159.1.210 Q9UEW8 STK39_HUMAN 78.165 0.995763 0.866055 STK39 - STE20/SPS1-related proline-alanine-rich protein kinase - Homo sapiens (Human) - STK39 gene May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT. Taurus_UMD|evm.model.AC_000159.1.211 Q9MYM7 B3GT1_PONPY 99.080 0.993884 1.00307 B3GALT1 - Beta-1,3-galactosyltransferase 1 - Pongo pygmaeus (Bornean orangutan) - B3GALT1 gene Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Taurus_UMD|evm.model.AC_000159.1.216 A4UGR9 XIRP2_HUMAN 78.684 0.998792 0.981624 XIRP2 - Xin actin-binding repeat-containing protein 2 - Homo sapiens (Human) - XIRP2 gene Protects actin filaments from depolymerization. Taurus_UMD|evm.model.AC_000159.1.219 Q01118 SCN7A_HUMAN 77.673 0.998812 1.00059 SCN7A - Sodium channel protein type 7 subunit alpha - Homo sapiens (Human) - SCN7A gene Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Taurus_UMD|evm.model.AC_000159.1.220 Q32KL4 RMD1_BOVIN 96.957 0.812057 0.88959 RMDN1 - Regulator of microtubule dynamics protein 1 - Bos taurus (Bovine) - RMDN1 gene cytoplasm, mitotic spindle pole, spindle microtubule, microtubule binding Taurus_UMD|evm.model.AC_000159.1.221 Q15858 SCN9A_HUMAN 93.587 0.998992 0.997988 SCN9A - Sodium channel protein type 9 subunit alpha - Homo sapiens (Human) - SCN9A gene Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784). Taurus_UMD|evm.model.AC_000159.1.222 A2APX8 SCN1A_MOUSE 94.805 0.999 0.99552 Scn1a - Sodium channel protein type 1 subunit alpha - Mus musculus (Mouse) - Scn1a gene Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:16921370, PubMed:17928448, PubMed:27281198). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons (PubMed:16921370, PubMed:22914087). Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli (PubMed:27281198). Taurus_UMD|evm.model.AC_000159.1.223 Q7Z4L5 TT21B_HUMAN 88.830 0.998451 0.981003 TTC21B - Tetratricopeptide repeat protein 21B - Homo sapiens (Human) - TTC21B gene Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs (PubMed:27932497). Negatively modulates the SHH signal transduction (By similarity). Taurus_UMD|evm.model.AC_000159.1.225 Q14435 GALT3_HUMAN 95.735 0.996845 1.00158 GALNT3 - Polypeptide N-acetylgalactosaminyltransferase 3 - Homo sapiens (Human) - GALNT3 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis. Taurus_UMD|evm.model.AC_000159.1.226 Q8WYN3 CSRN3_HUMAN 94.198 0.867756 1.15043 CSRNP3 - Cysteine/serine-rich nuclear protein 3 - Homo sapiens (Human) - CSRNP3 gene Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis (By similarity). Taurus_UMD|evm.model.AC_000159.1.227 Q99250 SCN2A_HUMAN 96.974 0.999005 1.00299 SCN2A - Sodium channel protein type 2 subunit alpha - Homo sapiens (Human) - SCN2A gene Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1325650, PubMed:17021166, PubMed:28256214, PubMed:29844171). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity). Taurus_UMD|evm.model.AC_000159.1.228 Q9NY46 SCN3A_HUMAN 95.337 0.999005 1.005 SCN3A - Sodium channel protein type 3 subunit alpha - Homo sapiens (Human) - SCN3A gene Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:24157691, PubMed:28235671, PubMed:29466837). May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells (By similarity). In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion (By similarity). Taurus_UMD|evm.model.AC_000159.1.229 Q5EA97 S38AB_BOVIN 93.952 0.995423 0.943844 SLC38A11 - Putative sodium-coupled neutral amino acid transporter 11 - Bos taurus (Bovine) - SLC38A11 gene Putative sodium-dependent amino acid/proton antiporter. Taurus_UMD|evm.model.AC_000159.1.230 Q53SF7 COBL1_HUMAN 72.340 0.147943 1.12057 COBLL1 - Cordon-bleu protein-like 1 - Homo sapiens (Human) - COBLL1 gene extracellular exosome, cadherin binding Taurus_UMD|evm.model.AC_000159.1.231 Q5ICW4 GRB14_BOVIN 99.630 0.996303 1.00185 GRB14 - Growth factor receptor-bound protein 14 - Bos taurus (Bovine) - GRB14 gene Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity). Taurus_UMD|evm.model.AC_000159.1.232 Q5HY92 FIGN_HUMAN 98.533 0.997337 0.98946 FIGN - Fidgetin - Homo sapiens (Human) - FIGN gene ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Taurus_UMD|evm.model.AC_000159.1.233 Q9NS40 KCNH7_HUMAN 99.029 0.87931 0.09699 KCNH7 - Potassium voltage-gated channel subfamily H member 7 - Homo sapiens (Human) - KCNH7 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Taurus_UMD|evm.model.AC_000159.1.234 P63170 DYL1_RAT 86.207 0.68595 1.35955 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Taurus_UMD|evm.model.AC_000159.1.235 Q9NS40 KCNH7_HUMAN 93.983 0.704333 0.984114 KCNH7 - Potassium voltage-gated channel subfamily H member 7 - Homo sapiens (Human) - KCNH7 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Taurus_UMD|evm.model.AC_000159.1.236 Q5RAI6 GRAN_PONAB 75.229 0.793651 1.15596 GCA - Grancalcin - Pongo abelii (Sumatran orangutan) - GCA gene Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions (By similarity). Taurus_UMD|evm.model.AC_000159.1.237 Q9BYX4 IFIH1_HUMAN 83.415 0.996086 0.997073 IFIH1 - Interferon-induced helicase C domain-containing protein 1 - Homo sapiens (Human) - IFIH1 gene Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Detects coronavirus SARS-CoV-2 (PubMed:33440148, PubMed:33514628). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. Taurus_UMD|evm.model.AC_000159.1.238 A5D7B7 SEPR_BOVIN 99.863 0.931122 1.03158 FAP - Prolyl endopeptidase FAP - Bos taurus (Bovine) - FAP gene Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2. Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein. Also has dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner. Taurus_UMD|evm.model.AC_000159.1.239 P01272 GLUC_BOVIN 100.000 0.988889 1 GCG - Pro-glucagon precursor - Bos taurus (Bovine) - GCG gene Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Taurus_UMD|evm.model.AC_000159.1.240 P81425 DPP4_BOVIN 100.000 0.770992 0.342484 DPP4 - Dipeptidyl peptidase 4 - Bos taurus (Bovine) - DPP4 gene Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Taurus_UMD|evm.model.AC_000159.1.241 P81425 DPP4_BOVIN 96.273 0.820513 0.254902 DPP4 - Dipeptidyl peptidase 4 - Bos taurus (Bovine) - DPP4 gene Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Taurus_UMD|evm.model.AC_000159.1.242 P81425 DPP4_BOVIN 100.000 0.988701 0.231373 DPP4 - Dipeptidyl peptidase 4 - Bos taurus (Bovine) - DPP4 gene Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Taurus_UMD|evm.model.AC_000159.1.243 Q32LP4 S4A10_BOVIN 100.000 0.644489 0.901522 SLC4A10 - Sodium-driven chloride bicarbonate exchanger - Bos taurus (Bovine) - SLC4A10 gene Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (By similarity). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity). Taurus_UMD|evm.model.AC_000159.1.244 Q28851 ATPK_BOVIN 78.873 0.526718 1.48864 ATP5MF - ATP synthase subunit f, mitochondrial - Bos taurus (Bovine) - ATP5MF gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Taurus_UMD|evm.model.AC_000159.1.245 Q16650 TBR1_HUMAN 99.560 0.997072 1.00147 TBR1 - T-box brain protein 1 - Homo sapiens (Human) - TBR1 gene Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:25232744, PubMed:30250039). As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity). Taurus_UMD|evm.model.AC_000159.1.246 O35593 PSDE_MOUSE 100.000 0.993569 1.00323 Psmd14 - 26S proteasome non-ATPase regulatory subunit 14 - Mus musculus (Mouse) - Psmd14 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. Taurus_UMD|evm.model.AC_000159.1.248 Q58DT1 RL7_BOVIN 92.254 0.979167 0.580645 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Taurus_UMD|evm.model.AC_000159.1.249 Q92844 TANK_HUMAN 87.294 0.995272 0.995294 TANK - TRAF family member-associated NF-kappa-B activator - Homo sapiens (Human) - TANK gene Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Taurus_UMD|evm.model.AC_000159.1.250 Q3ZBP3 RBMS1_BOVIN 98.438 0.945679 1.00496 RBMS1 - RNA-binding motif, single-stranded-interacting protein 1 - Bos taurus (Bovine) - RBMS1 gene Single-stranded DNA binding protein that interacts with the region upstream of the C-myc gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication (By similarity). Taurus_UMD|evm.model.AC_000159.1.251 Q8SQB8 ITB6_BOVIN 100.000 0.972806 1.02665 ITGB6 - Integrin beta-6 precursor - Bos taurus (Bovine) - ITGB6 gene Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). Taurus_UMD|evm.model.AC_000159.1.252 P49259 PLA2R_BOVIN 100.000 0.998634 1.00068 PLA2R1 - Secretory phospholipase A2 receptor precursor - Bos taurus (Bovine) - PLA2R1 gene Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10. Taurus_UMD|evm.model.AC_000159.1.253 O60449 LY75_HUMAN 79.977 0.99884 1.00116 LY75 - Lymphocyte antigen 75 precursor - Homo sapiens (Human) - LY75 gene Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes. Taurus_UMD|evm.model.AC_000159.1.254 A8WH74 CD302_BOVIN 100.000 0.991416 1.00431 CD302 - CD302 antigen precursor - Bos taurus (Bovine) - CD302 gene Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration. Taurus_UMD|evm.model.AC_000159.1.255 Q9H992 MARH7_HUMAN 86.723 0.997151 0.997159 MARCHF7 - E3 ubiquitin-protein ligase MARCHF7 - Homo sapiens (Human) - MARCHF7 gene E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Taurus_UMD|evm.model.AC_000159.1.258 Q9UIF8 BAZ2B_HUMAN 91.376 0.230976 1.20018 BAZ2B - Bromodomain adjacent to zinc finger domain protein 2B - Homo sapiens (Human) - BAZ2B gene Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). Taurus_UMD|evm.model.AC_000159.1.259 Q9C0D5 TANC1_HUMAN 88.412 0.998915 0.990865 TANC1 - Protein TANC1 - Homo sapiens (Human) - TANC1 gene May be a scaffold component in the postsynaptic density. Taurus_UMD|evm.model.AC_000159.1.260 A2VEA7 DAPL1_BOVIN 100.000 0.981481 1.00935 DAPL1 - Death-associated protein-like 1 - Bos taurus (Bovine) - DAPL1 gene May play a role in the early stages of epithelial differentiation or in apoptosis. Taurus_UMD|evm.model.AC_000159.1.261 Q99569 PKP4_HUMAN 97.636 0.964881 0.955537 PKP4 - Plakophilin-4 - Homo sapiens (Human) - PKP4 gene Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. Taurus_UMD|evm.model.AC_000159.1.262 Q8NFR7 CC148_HUMAN 78.967 0.882456 0.964467 CCDC148 - Coiled-coil domain-containing protein 148 - Homo sapiens (Human) - CCDC148 gene Taurus_UMD|evm.model.AC_000159.1.263 O95045 UPP2_HUMAN 88.959 0.984424 1.01262 UPP2 - Uridine phosphorylase 2 - Homo sapiens (Human) - UPP2 gene Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:12849978, PubMed:21855639). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable). Shows broad substrate specificity and accepts uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates (PubMed:12849978). Taurus_UMD|evm.model.AC_000159.1.264 Q8NER5 ACV1C_HUMAN 97.644 0.994778 0.776876 ACVR1C - Activin receptor type-1C precursor - Homo sapiens (Human) - ACVR1C gene Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Taurus_UMD|evm.model.AC_000159.1.265 O60759 CYTIP_HUMAN 84.444 0.994429 1 CYTIP - Cytohesin-interacting protein - Homo sapiens (Human) - CYTIP gene By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm. Taurus_UMD|evm.model.AC_000159.1.266 Q3ZBR9 ERMIN_BOVIN 100.000 0.875 0.992908 ERMN - Ermin - Bos taurus (Bovine) - ERMN gene Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity). Taurus_UMD|evm.model.AC_000159.1.267 Q10126 YSM6_CAEEL 27.215 0.633929 0.802867 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000159.1.268 Q7Z7M9 GALT5_HUMAN 80.618 0.996812 1.00106 GALNT5 - Polypeptide N-acetylgalactosaminyltransferase 5 - Homo sapiens (Human) - GALNT5 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity). Taurus_UMD|evm.model.AC_000159.1.269 Q28041 ACVR1_BOVIN 99.804 0.868376 1.14931 ACVR1 - Activin receptor type-1 precursor - Bos taurus (Bovine) - ACVR1 gene Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A ors ACVR2B. Upon binding of ligands such as BMP7 or BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, can activate non-canonical signaling pathways. Taurus_UMD|evm.model.AC_000159.1.272 A6QLU1 GPDM_BOVIN 100.000 0.997253 1.00138 GPD2 - Glycerol-3-phosphate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - GPD2 gene Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. Taurus_UMD|evm.model.AC_000159.1.273 Q08E53 NR4A2_BOVIN 100.000 0.917051 1.08863 NR4A2 - Nuclear receptor subfamily 4 group A member 2 - Bos taurus (Bovine) - NR4A2 gene Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). Taurus_UMD|evm.model.AC_000159.1.274 E1BNE9 KCNJ3_BOVIN 100.000 0.996016 1.002 KCNJ3 - G protein-activated inward rectifier potassium channel 1 - Bos taurus (Bovine) - KCNJ3 gene This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. Taurus_UMD|evm.model.AC_000159.1.275 Q4U5R4 RN114_BOVIN 54.217 0.780952 0.456522 RNF114 - E3 ubiquitin-protein ligase RNF114 - Bos taurus (Bovine) - RNF114 gene E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation. Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C. This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis. Taurus_UMD|evm.model.AC_000159.1.276 Q8IUC8 GLT13_HUMAN 99.460 0.996409 1.0018 GALNT13 - Polypeptide N-acetylgalactosaminyltransferase 13 - Homo sapiens (Human) - GALNT13 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a much stronger activity than GALNT1 to transfer GalNAc to mucin peptides, such as Muc5Ac and Muc7. Able to glycosylate SDC3. May be responsible for the synthesis of Tn antigen in neuronal cells. Taurus_UMD|evm.model.AC_000159.1.277 Q1RMT2 RPRM_BOVIN 100.000 0.981818 1.00917 RPRM - Protein reprimo - Bos taurus (Bovine) - RPRM gene May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity). Taurus_UMD|evm.model.AC_000159.1.278 Q5NVP9 MO4L1_PONAB 96.629 0.926829 0.888545 MORF4L1 - Mortality factor 4-like protein 1 - Pongo abelii (Sumatran orangutan) - MORF4L1 gene Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci (By similarity). Taurus_UMD|evm.model.AC_000159.1.279 Q56JZ1 RL13_BOVIN 90.047 0.990521 1 RPL13 - 60S ribosomal protein L13 - Bos taurus (Bovine) - RPL13 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the LSU, it is probably required for its formation and the maturation of rRNAs. Plays a role in bone development. Taurus_UMD|evm.model.AC_000159.1.280 Q3MHM8 AR6P6_BOVIN 100.000 0.991189 1.00442 ARL6IP6 - ADP-ribosylation factor-like protein 6-interacting protein 6 - Bos taurus (Bovine) - ARL6IP6 gene nuclear inner membrane Taurus_UMD|evm.model.AC_000159.1.281 O75400 PR40A_HUMAN 94.566 0.98172 0.971787 PRPF40A - Pre-mRNA-processing factor 40 homolog A - Homo sapiens (Human) - PRPF40A gene Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000159.1.282 Q96PY5 FMNL2_HUMAN 96.831 0.97989 1.00737 FMNL2 - Formin-like protein 2 - Homo sapiens (Human) - FMNL2 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. Taurus_UMD|evm.model.AC_000159.1.283 O75886 STAM2_HUMAN 92.593 0.937811 0.765714 STAM2 - Signal transducing adapter molecule 2 - Homo sapiens (Human) - STAM2 gene Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). Taurus_UMD|evm.model.AC_000159.1.284 O00305 CACB4_HUMAN 92.781 0.99095 0.85 CACNB4 - Voltage-dependent L-type calcium channel subunit beta-4 - Homo sapiens (Human) - CACNB4 gene The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Taurus_UMD|evm.model.AC_000159.1.285 Q2KJ96 ARL5A_BOVIN 100.000 0.987879 0.921788 ARL5A - ADP-ribosylation factor-like protein 5A - Bos taurus (Bovine) - ARL5A gene Lacks ADP-ribosylation enhancing activity. Taurus_UMD|evm.model.AC_000159.1.286 Q3B7M5 LASP1_BOVIN 76.562 0.00841234 28.8038 LASP1 - LIM and SH3 domain protein 1 - Bos taurus (Bovine) - LASP1 gene Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). Taurus_UMD|evm.model.AC_000159.1.288 Q5UIP0 RIF1_HUMAN 79.403 0.999189 0.997573 RIF1 - Telomere-associated protein RIF1 - Homo sapiens (Human) - RIF1 gene Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). Taurus_UMD|evm.model.AC_000159.1.289 P98066 TSG6_HUMAN 94.424 0.953737 1.01444 TNFAIP6 - Tumor necrosis factor-inducible gene 6 protein precursor - Homo sapiens (Human) - TNFAIP6 gene Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. Taurus_UMD|evm.model.AC_000159.1.290 P46777 RL5_HUMAN 71.374 0.973913 0.774411 RPL5 - 60S ribosomal protein L5 - Homo sapiens (Human) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868, PubMed:23636399). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Taurus_UMD|evm.model.AC_000159.1.291 Q3ZCL3 NMI_BOVIN 99.676 0.76808 1.29773 NMI - N-myc-interactor - Bos taurus (Bovine) - NMI gene Acts as a signaling pathway regulator involved in innate immune system response. In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis. Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription. In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35. In complex with IFI35, inhibits virus-triggered type I IFN-beta production when ubiquitinated by ubiquitin-protein ligase TRIM21. In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (By similarity). Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses (By similarity). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion. Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of proinflammatory cytokines (By similarity). Taurus_UMD|evm.model.AC_000159.1.292 Q6ZSC3 RBM43_HUMAN 63.764 0.991279 0.963585 RBM43 - RNA-binding protein 43 - Homo sapiens (Human) - RBM43 gene Taurus_UMD|evm.model.AC_000159.1.294 Q6SA80 RND3_RAT 100.000 0.991837 1.0041 Rnd3 - Rho-related GTP-binding protein RhoE precursor - Rattus norvegicus (Rat) - Rnd3 gene Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Taurus_UMD|evm.model.AC_000159.1.296 Q9R0Q3 TMED2_MOUSE 87.059 0.756757 0.552239 Tmed2 - Transmembrane emp24 domain-containing protein 2 precursor - Mus musculus (Mouse) - Tmed2 gene Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing (By similarity). Required for morphogenesis of embryo and placenta. Taurus_UMD|evm.model.AC_000159.1.297 Q9H3L0 MMAD_HUMAN 96.622 0.993266 1.00338 MMADHC - Cobalamin trafficking protein CblD precursor - Homo sapiens (Human) - MMADHC gene Involved in cobalamin metabolism and trafficking (PubMed:18385497, PubMed:23415655, PubMed:24722857, PubMed:26364851). Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl) (PubMed:18385497,PubMed:23415655, PubMed:24722857). Promotes oxidation of cob(II)alamin bound to MMACHC (PubMed:26364851). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:27771510). Taurus_UMD|evm.model.AC_000159.1.298 Q86Y78 LYPD6_HUMAN 61.702 0.986577 0.871345 LYPD6 - Ly6/PLAUR domain-containing protein 6 precursor - Homo sapiens (Human) - LYPD6 gene Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs (PubMed:27344019). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity). Taurus_UMD|evm.model.AC_000159.1.299 Q8NI32 LPD6B_HUMAN 92.308 0.988235 0.928962 LYPD6B - Ly6/PLAUR domain-containing protein 6B precursor - Homo sapiens (Human) - LYPD6B gene Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence. Taurus_UMD|evm.model.AC_000159.1.300 O60282 KIF5C_HUMAN 99.133 0.944672 1.01985 KIF5C - Kinesin heavy chain isoform 5C - Homo sapiens (Human) - KIF5C gene Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Taurus_UMD|evm.model.AC_000159.1.301 Q52LR7 EPC2_HUMAN 97.398 0.997525 1.00124 EPC2 - Enhancer of polycomb homolog 2 - Homo sapiens (Human) - EPC2 gene May play a role in transcription or DNA repair. Taurus_UMD|evm.model.AC_000159.1.303 Q9P267 MBD5_HUMAN 96.875 0.55254 1.1593 MBD5 - Methyl-CpG-binding domain protein 5 - Homo sapiens (Human) - MBD5 gene Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro). Taurus_UMD|evm.model.AC_000159.1.304 P01252 PTMA_BOVIN 96.364 0.981818 1 PTMA - Prothymosin alpha - Bos taurus (Bovine) - PTMA gene Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Taurus_UMD|evm.model.AC_000159.1.306 Q2YDI2 ORC4_BOVIN 100.000 0.995423 1.00229 ORC4 - Origin recognition complex subunit 4 - Bos taurus (Bovine) - ORC4 gene Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). Taurus_UMD|evm.model.AC_000159.1.307 Q28043 AVR2A_BOVIN 100.000 0.996109 1.00195 ACVR2A - Activin receptor type-2A precursor - Bos taurus (Bovine) - ACVR2A gene On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6. Taurus_UMD|evm.model.AC_000159.1.310 Q32L59 TMC5B_BOVIN 93.182 0.149306 0.820513 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Taurus_UMD|evm.model.AC_000159.1.313 P62315 SMD1_MOUSE 96.522 0.844444 1.13445 Snrpd1 - Small nuclear ribonucleoprotein Sm D1 - Mus musculus (Mouse) - Snrpd1 gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. Taurus_UMD|evm.model.AC_000159.1.314 Q6GQS1 SCMC3_MOUSE 75.540 0.985612 0.297645 Slc25a23 - Calcium-binding mitochondrial carrier protein SCaMC-3 - Mus musculus (Mouse) - Slc25a23 gene Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. Acts as a regulator of mitochondrial calcium uptake via interaction with MCU and MICU1. Taurus_UMD|evm.model.AC_000159.1.315 O97725 NDUAC_BOVIN 99.000 0.961165 0.710345 NDUFA12 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 - Bos taurus (Bovine) - NDUFA12 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000159.1.316 Q5R613 SNX6_PONAB 96.244 0.990654 0.527094 SNX6 - Sorting nexin-6 - Pongo abelii (Sumatran orangutan) - SNX6 gene Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation. In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B. May contribute to transcription regulation (By similarity). Taurus_UMD|evm.model.AC_000159.1.319 O60315 ZEB2_HUMAN 98.435 0.998354 1.00082 ZEB2 - Zinc finger E-box-binding homeobox 2 - Homo sapiens (Human) - ZEB2 gene Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). Taurus_UMD|evm.model.AC_000159.1.320 Q08DA7 GTDC1_BOVIN 100.000 0.628319 1.23497 GTDC1 - Glycosyltransferase-like domain-containing protein 1 - Bos taurus (Bovine) - GTDC1 gene Taurus_UMD|evm.model.AC_000159.1.323 A4IF90 RHG15_BOVIN 100.000 0.912791 0.36518 ARHGAP15 - Rho GTPase-activating protein 15 - Bos taurus (Bovine) - ARHGAP15 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction (By similarity). Taurus_UMD|evm.model.AC_000159.1.324 Q16719 KYNU_HUMAN 71.706 0.91866 0.898925 KYNU - Kynureninase - Homo sapiens (Human) - KYNU gene Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Taurus_UMD|evm.model.AC_000159.1.325 P16423 POLR_DROME 28.125 0.505669 0.417219 pol - Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM - Drosophila melanogaster (Fruit fly) - pol gene Taurus_UMD|evm.model.AC_000159.1.326 Q16778 H2B2E_HUMAN 90.278 0.959459 0.587302 H2BC21 - Histone H2B type 2-E - Homo sapiens (Human) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000159.1.327 Q6R6M4 U17L2_HUMAN 35.393 0.965517 0.328302 USP17L2 - Ubiquitin carboxyl-terminal hydrolase 17 - Homo sapiens (Human) - USP17L2 gene Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection. Taurus_UMD|evm.model.AC_000159.1.332 Q8VH49 HIG1A_RAT 83.871 0.938776 1.05376 Higd1a - HIG1 domain family member 1A, mitochondrial - Rattus norvegicus (Rat) - Higd1a gene Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). Taurus_UMD|evm.model.AC_000159.1.335 Q9NZR2 LRP1B_HUMAN 81.786 0.861386 0.131768 LRP1B - Low-density lipoprotein receptor-related protein 1B precursor - Homo sapiens (Human) - LRP1B gene Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. Taurus_UMD|evm.model.AC_000159.1.336 Q9NZR2 LRP1B_HUMAN 72.010 0.970199 0.0656664 LRP1B - Low-density lipoprotein receptor-related protein 1B precursor - Homo sapiens (Human) - LRP1B gene Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. Taurus_UMD|evm.model.AC_000159.1.337 Q9NZR2 LRP1B_HUMAN 96.667 0.832669 0.0545771 LRP1B - Low-density lipoprotein receptor-related protein 1B precursor - Homo sapiens (Human) - LRP1B gene Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. Taurus_UMD|evm.model.AC_000159.1.338 Q9NZR2 LRP1B_HUMAN 94.628 0.998937 0.409002 LRP1B - Low-density lipoprotein receptor-related protein 1B precursor - Homo sapiens (Human) - LRP1B gene Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. Taurus_UMD|evm.model.AC_000159.1.339 Q9UHQ1 NARF_HUMAN 76.087 0.236842 0.416667 NARF - Nuclear prelamin A recognition factor - Homo sapiens (Human) - NARF gene lamin filament, nuclear lamina, nuclear lumen, nucleolus, nucleoplasm, lamin binding Taurus_UMD|evm.model.AC_000159.1.340 P16116 ALDR_BOVIN 77.903 0.991837 0.777778 AKR1B1 - Aldo-keto reductase family 1 member B1 - Bos taurus (Bovine) - AKR1B1 gene Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Taurus_UMD|evm.model.AC_000159.1.341 Q5PSV4 BRM1L_HUMAN 98.596 0.965986 0.910217 BRMS1L - Breast cancer metastasis-suppressor 1-like protein - Homo sapiens (Human) - BRMS1L gene Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth. Taurus_UMD|evm.model.AC_000159.1.342 Q28145 NXPH2_BOVIN 100.000 0.992453 1.00379 NXPH2 - Neurexophilin-2 precursor - Bos taurus (Bovine) - NXPH2 gene May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Taurus_UMD|evm.model.AC_000159.1.343 Q6IQ16 SPOPL_HUMAN 97.959 0.944444 1.05612 SPOPL - Speckle-type POZ protein-like - Homo sapiens (Human) - SPOPL gene Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP. Taurus_UMD|evm.model.AC_000159.1.345 Q58DV7 HNMT_BOVIN 92.079 0.993421 1.0411 HNMT - Histamine N-methyltransferase - Bos taurus (Bovine) - HNMT gene Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. Taurus_UMD|evm.model.AC_000159.1.347 Q2HJH8 CF300_BOVIN 96.825 0.696629 0.333333 CFAP300 - Cilia- and flagella-associated protein 300 - Bos taurus (Bovine) - CFAP300 gene Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly. Taurus_UMD|evm.model.AC_000159.1.348 Q9C0I4 THS7B_HUMAN 90.931 0.990521 0.262765 THSD7B - Thrombospondin type-1 domain-containing protein 7B precursor - Homo sapiens (Human) - THSD7B gene plasma membrane, actin cytoskeleton reorganization Taurus_UMD|evm.model.AC_000159.1.349 Q9C0I4 THS7B_HUMAN 86.942 0.900621 0.200498 THSD7B - Thrombospondin type-1 domain-containing protein 7B precursor - Homo sapiens (Human) - THSD7B gene plasma membrane, actin cytoskeleton reorganization Taurus_UMD|evm.model.AC_000159.1.356 A5A6H4 ROA1_PANTR 96.296 0.61039 0.9625 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Pan troglodytes (Chimpanzee) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. Taurus_UMD|evm.model.AC_000159.1.358 P25930 CXCR4_BOVIN 100.000 0.99435 1.00283 CXCR4 - C-X-C chemokine receptor type 4 - Bos taurus (Bovine) - CXCR4 gene Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). Taurus_UMD|evm.model.AC_000159.1.359 Q3SYZ4 SYDC_BOVIN 91.417 0.995671 0.922156 DARS1 - Aspartate--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - DARS1 gene Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Taurus_UMD|evm.model.AC_000159.1.360 Q2KIZ8 MCM6_BOVIN 99.594 0.266715 3.37028 MCM6 - DNA replication licensing factor MCM6 - Bos taurus (Bovine) - MCM6 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Taurus_UMD|evm.model.AC_000159.1.361 Q3ZBU9 UBXN4_BOVIN 100.000 0.996071 1.00197 UBXN4 - UBX domain-containing protein 4 - Bos taurus (Bovine) - UBXN4 gene Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD. Taurus_UMD|evm.model.AC_000159.1.362 Q8K003 TMA7_MOUSE 95.349 0.626866 1.04688 Tma7 - Translation machinery-associated protein 7 - Mus musculus (Mouse) - Tma7 gene cytoplasmic translation Taurus_UMD|evm.model.AC_000159.1.363 Q15032 R3HD1_HUMAN 91.381 0.998235 1.03094 R3HDM1 - R3H domain-containing protein 1 - Homo sapiens (Human) - R3HDM1 gene RNA binding Taurus_UMD|evm.model.AC_000159.1.365 E1BB03 ZRAB3_BOVIN 99.628 0.998133 0.997207 ZRANB3 - DNA annealing helicase and endonuclease ZRANB3 - Bos taurus (Bovine) - ZRANB3 gene DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks. Taurus_UMD|evm.model.AC_000159.1.366 Q15042 RB3GP_HUMAN 95.112 0.997965 1.00204 RAB3GAP1 - Rab3 GTPase-activating protein catalytic subunit - Homo sapiens (Human) - RAB3GAP1 gene Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. Taurus_UMD|evm.model.AC_000159.1.367 Q56UN5 M3K19_HUMAN 72.915 0.863005 1.1378 MAP3K19 - Mitogen-activated protein kinase kinase kinase 19 - Homo sapiens (Human) - MAP3K19 gene Taurus_UMD|evm.model.AC_000159.1.368 O60583 CCNT2_HUMAN 93.533 0.948872 0.910959 CCNT2 - Cyclin-T2 - Homo sapiens (Human) - CCNT2 gene Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity). Taurus_UMD|evm.model.AC_000159.1.369 Q0II68 ACMSD_BOVIN 100.000 0.994065 1.00298 ACMSD - 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase - Bos taurus (Bovine) - ACMSD gene Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway (By similarity). Taurus_UMD|evm.model.AC_000159.1.370 A6QQX9 TM163_BOVIN 99.160 0.874074 0.470383 TMEM163 - Transmembrane protein 163 - Bos taurus (Bovine) - TMEM163 gene May bind zinc and other divalent cations and recruit them to vesicular organelles. Taurus_UMD|evm.model.AC_000159.1.371 Q09328 MGT5A_HUMAN 95.816 0.913366 1.09042 MGAT5 - Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A precursor - Homo sapiens (Human) - MGAT5 gene Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides (PubMed:10395745, PubMed:30140003). Catalyzes an important step in the biosynthesis of branched, complex-type N-glycans, such as those found on EGFR, TGFR (TGF-beta receptor) and CDH2 (PubMed:10395745, PubMed:22614033, PubMed:30140003). Via its role in the biosynthesis of complex N-glycans, plays an important role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration. MGAT5-dependent EGFR N-glycosylation enhances the interaction between EGFR and LGALS3 and thereby prevents rapid EGFR endocytosis and prolongs EGFR signaling. Required for efficient interaction between TGFB1 and its receptor. Enhances activation of intracellular signaling pathways by several types of growth factors, including FGF2, PDGF, IGF, TGFB1 and EGF. MGAT5-dependent CDH2 N-glycosylation inhibits CDH2-mediated homotypic cell-cell adhesion and contributes to the regulation of downstream signaling pathways. Promotes cell migration. Contributes to the regulation of the inflammatory response. MGAT5-dependent TCR N-glycosylation enhances the interaction between TCR and LGALS3, limits agonist-induced TCR clustering, and thereby dampens TCR-mediated responses to antigens. Required for normal leukocyte evasation and accumulation at sites of inflammation (By similarity). Inhibits attachment of monocytes to the vascular endothelium and subsequent monocyte diapedesis (PubMed:22614033). Taurus_UMD|evm.model.AC_000159.1.373 O14513 NCKP5_HUMAN 100.000 0.986842 0.0398114 NCKAP5 - Nck-associated protein 5 - Homo sapiens (Human) - NCKAP5 gene microtubule plus-end, microtubule bundle formation, microtubule depolymerization Taurus_UMD|evm.model.AC_000159.1.374 O14513 NCKP5_HUMAN 72.076 0.969591 0.895757 NCKAP5 - Nck-associated protein 5 - Homo sapiens (Human) - NCKAP5 gene microtubule plus-end, microtubule bundle formation, microtubule depolymerization Taurus_UMD|evm.model.AC_000159.1.375 Q8N2G4 LYPD1_HUMAN 92.908 0.985915 1.00709 LYPD1 - Ly6/PLAUR domain-containing protein 1 precursor - Homo sapiens (Human) - LYPD1 gene Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety. Taurus_UMD|evm.model.AC_000159.1.376 B4XF06 GPR39_BOVIN 100.000 0.818627 0.449339 GPR39 - G-protein coupled receptor 39 - Bos taurus (Bovine) - GPR39 gene Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity). Taurus_UMD|evm.model.AC_000159.1.377 B4XF06 GPR39_BOVIN 100.000 0.916129 0.682819 GPR39 - G-protein coupled receptor 39 - Bos taurus (Bovine) - GPR39 gene Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity). Taurus_UMD|evm.model.AC_000159.1.378 A6QL92 S35F5_BOVIN 100.000 0.99619 1.00191 SLC35F5 - Solute carrier family 35 member F5 - Bos taurus (Bovine) - SLC35F5 gene Putative solute transporter. Taurus_UMD|evm.model.AC_000159.1.379 Q5R8R1 ARP3_PONAB 100.000 0.994565 0.880383 ACTR3 - Actin-related protein 3 - Pongo abelii (Sumatran orangutan) - ACTR3 gene ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis. Taurus_UMD|evm.model.AC_000159.1.380 Q3TUA9 SG196_MOUSE 56.548 0.963211 0.856734 Pomk - Protein O-mannose kinase - Mus musculus (Mouse) - Pomk gene Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif (By similarity). Taurus_UMD|evm.model.AC_000159.1.384 Q8N608 DPP10_HUMAN 87.246 0.99705 0.851759 DPP10 - Inactive dipeptidyl peptidase 10 - Homo sapiens (Human) - DPP10 gene Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155). Taurus_UMD|evm.model.AC_000159.1.385 P15103 GLNA_BOVIN 95.775 0.426829 0.439678 GLUL - Glutamine synthetase - Bos taurus (Bovine) - GLUL gene Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). Taurus_UMD|evm.model.AC_000159.1.386 O15439 MRP4_HUMAN 91.667 0.951613 0.0467925 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000159.1.388 Q6ZRP0 PR23C_HUMAN 40.152 0.75 0.610687 PRR23C - Proline-rich protein 23C - Homo sapiens (Human) - PRR23C gene Taurus_UMD|evm.model.AC_000159.1.389 P04394 NDUV2_BOVIN 69.828 0.760331 0.485944 NDUFV2 - NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor - Bos taurus (Bovine) - NDUFV2 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Taurus_UMD|evm.model.AC_000159.1.390 O00370 LORF2_HUMAN 30.894 0.947917 0.301176 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000159.1.391 Q9NVP1 DDX18_HUMAN 88.125 0.838371 1.13582 DDX18 - ATP-dependent RNA helicase DDX18 - Homo sapiens (Human) - DDX18 gene Probable RNA-dependent helicase. Taurus_UMD|evm.model.AC_000159.1.392 P35365 5HT5B_RAT 80.549 0.985185 1.09459 Htr5b - 5-hydroxytryptamine receptor 5B - Rattus norvegicus (Rat) - Htr5b gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. Probably involved in anxiety and depression. Taurus_UMD|evm.model.AC_000159.1.393 Q567U6 CCD93_HUMAN 93.661 0.996835 1.00158 CCDC93 - Coiled-coil domain-containing protein 93 - Homo sapiens (Human) - CCDC93 gene Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:28892079, PubMed:25355947). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C (PubMed:25355947). Taurus_UMD|evm.model.AC_000159.1.394 Q9Y5U4 INSI2_HUMAN 99.111 0.99115 1.00444 INSIG2 - Insulin-induced gene 2 protein - Homo sapiens (Human) - INSIG2 gene Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:26160948, PubMed:17428920, PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139 (PubMed:16606821, PubMed:22143767). Taurus_UMD|evm.model.AC_000159.1.398 P09065 HME1_MOUSE 92.208 0.760599 1 En1 - Homeobox protein engrailed-1 - Mus musculus (Mouse) - En1 gene membrane, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, adult locomotory behavior, cerebellum development, dopaminergic neuron differentiation, dorsal/ventral pattern formation Taurus_UMD|evm.model.AC_000159.1.400 Q9UEW3 MARCO_HUMAN 66.312 0.695652 0.751923 MARCO - Macrophage receptor MARCO - Homo sapiens (Human) - MARCO gene Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263). Taurus_UMD|evm.model.AC_000159.1.401 Q8CFR0 C1QL2_MOUSE 96.167 0.993056 1.00348 C1ql2 - Complement C1q-like protein 2 precursor - Mus musculus (Mouse) - C1ql2 gene May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Taurus_UMD|evm.model.AC_000159.1.402 P16116 ALDR_BOVIN 80.000 0.904762 0.4 AKR1B1 - Aldo-keto reductase family 1 member B1 - Bos taurus (Bovine) - AKR1B1 gene Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Taurus_UMD|evm.model.AC_000159.1.403 Q658P3 STEA3_HUMAN 88.636 0.995876 0.993852 STEAP3 - Metalloreductase STEAP3 - Homo sapiens (Human) - STEAP3 gene Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. Taurus_UMD|evm.model.AC_000159.1.404 Q32KX9 CB076_BOVIN 86.508 0.981818 0.873016 UPF0538 protein C2orf76 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000159.1.405 P07107 ACBP_BOVIN 100.000 0.977273 1.01149 DBI - Acyl-CoA-binding protein - Bos taurus (Bovine) - DBI gene Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. Taurus_UMD|evm.model.AC_000159.1.407 Q8WXS4 CCGL_HUMAN 69.036 0.960784 1.07368 TMEM37 - Voltage-dependent calcium channel gamma-like subunit - Homo sapiens (Human) - TMEM37 gene Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity). Taurus_UMD|evm.model.AC_000159.1.408 P47872 SCTR_HUMAN 85.203 0.890086 1.05455 SCTR - Secretin receptor precursor - Homo sapiens (Human) - SCTR gene Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:7612008, PubMed:25332973). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity). Taurus_UMD|evm.model.AC_000159.1.409 Q4G0U5 PCDP1_HUMAN 76.711 0.989529 0.909524 CFAP221 - Cilia- and flagella-associated protein 221 - Homo sapiens (Human) - CFAP221 gene May play a role in cilium morphogenesis. Taurus_UMD|evm.model.AC_000159.1.410 Q4KM93 TM177_RAT 82.201 0.987179 1.00322 Tmem177 - Transmembrane protein 177 - Rattus norvegicus (Rat) - Tmem177 gene Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. Taurus_UMD|evm.model.AC_000159.1.412 Q58CU2 E41L5_BOVIN 99.775 0.612725 1.44024 EPB41L5 - Band 4.1-like protein 5 - Bos taurus (Bovine) - EPB41L5 gene Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. Taurus_UMD|evm.model.AC_000159.1.413 Q08DE2 T185B_BOVIN 100.000 0.994302 1.00286 TMEM185B - Transmembrane protein 185B - Bos taurus (Bovine) - TMEM185B gene Taurus_UMD|evm.model.AC_000159.1.414 Q5R4B8 RALB_PONAB 98.544 0.990338 1.00485 RALB - Ras-related protein Ral-B precursor - Pongo abelii (Sumatran orangutan) - RALB gene Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (By similarity). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (By similarity). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (By similarity). Taurus_UMD|evm.model.AC_000159.1.415 P42917 INHBB_BOVIN 99.755 0.99511 1.00245 INHBB - Inhibin beta B chain precursor - Bos taurus (Bovine) - INHBB gene Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Taurus_UMD|evm.model.AC_000159.1.416 Q3MHL7 TCPZ_BOVIN 95.614 0.982609 0.216573 CCT6A - T-complex protein 1 subunit zeta - Bos taurus (Bovine) - CCT6A gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin. Taurus_UMD|evm.model.AC_000159.1.417 Q3MHL7 TCPZ_BOVIN 76.308 0.888889 0.59322 CCT6A - T-complex protein 1 subunit zeta - Bos taurus (Bovine) - CCT6A gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin. Taurus_UMD|evm.model.AC_000159.1.419 P10070 GLI2_HUMAN 85.306 0.981308 0.944515 GLI2 - Zinc finger protein GLI2 - Homo sapiens (Human) - GLI2 gene Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). Taurus_UMD|evm.model.AC_000159.1.420 Q9NZI6 TF2L1_HUMAN 96.660 0.995833 1.00209 TFCP2L1 - Transcription factor CP2-like protein 1 - Homo sapiens (Human) - TFCP2L1 gene Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity). Modulates the placental expression of CYP11A1 (PubMed:10644752). Taurus_UMD|evm.model.AC_000159.1.422 Q7Z460 CLAP1_HUMAN 92.442 0.998643 0.958388 CLASP1 - CLIP-associating protein 1 - Homo sapiens (Human) - CLASP1 gene Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Taurus_UMD|evm.model.AC_000159.1.423 Q3SZM1 MK67I_BOVIN 100.000 0.993266 1.00338 NIFK - MKI67 FHA domain-interacting nucleolar phosphoprotein - Bos taurus (Bovine) - NIFK gene nucleolus, RNA binding, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000159.1.424 Q08DM8 TSN_BOVIN 100.000 0.991266 1.00439 TSN - Translin - Bos taurus (Bovine) - TSN gene DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots (By similarity). Taurus_UMD|evm.model.AC_000159.1.426 Q9HBK9 AS3MT_HUMAN 74.684 0.709091 0.293333 AS3MT - Arsenite methyltransferase - Homo sapiens (Human) - AS3MT gene Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed:16407288, PubMed:25997655). It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 (PubMed:16407288, PubMed:25997655). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (PubMed:16407288, PubMed:25997655). Taurus_UMD|evm.model.AC_000159.1.428 P62936 PPIA_PIG 84.049 0.915254 1.07927 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Taurus_UMD|evm.model.AC_000159.1.430 Q8IVU1 IGDC3_HUMAN 53.659 0.970817 0.63145 IGDCC3 - Immunoglobulin superfamily DCC subclass member 3 precursor - Homo sapiens (Human) - IGDCC3 gene Taurus_UMD|evm.model.AC_000159.1.432 Q0V8T0 CNTP5_CANLF 99.000 0.825 0.091954 CNTNAP5 - Contactin-associated protein-like 5 precursor - Canis lupus familiaris (Dog) - CNTNAP5 gene May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication. Taurus_UMD|evm.model.AC_000159.1.434 Q0V8T0 CNTP5_CANLF 94.976 0.995227 0.321073 CNTNAP5 - Contactin-associated protein-like 5 precursor - Canis lupus familiaris (Dog) - CNTNAP5 gene May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication. Taurus_UMD|evm.model.AC_000159.1.435 Q8WYK1 CNTP5_HUMAN 79.528 0.853147 0.109495 CNTNAP5 - Contactin-associated protein-like 5 precursor - Homo sapiens (Human) - CNTNAP5 gene May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication. Taurus_UMD|evm.model.AC_000159.1.436 Q8WYK1 CNTP5_HUMAN 86.875 0.989627 0.369066 CNTNAP5 - Contactin-associated protein-like 5 precursor - Homo sapiens (Human) - CNTNAP5 gene May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication. Taurus_UMD|evm.model.AC_000159.1.437 Q5E954 DNJA1_BOVIN 96.491 0.988372 0.433249 DNAJA1 - DnaJ homolog subfamily A member 1 precursor - Bos taurus (Bovine) - DNAJA1 gene Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Taurus_UMD|evm.model.AC_000159.1.438 Q5NVI9 DNJA1_PONAB 84.091 0.989474 0.479798 DNAJA1 - DnaJ homolog subfamily A member 1 precursor - Pongo abelii (Sumatran orangutan) - DNAJA1 gene Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Taurus_UMD|evm.model.AC_000159.1.439 Q96LD8 SENP8_HUMAN 77.251 0.914692 0.995283 SENP8 - Sentrin-specific protease 8 - Homo sapiens (Human) - SENP8 gene Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. Taurus_UMD|evm.model.AC_000159.1.440 O43166 SI1L1_HUMAN 100.000 0.973684 0.0421286 SIPA1L1 - Signal-induced proliferation-associated 1-like protein 1 - Homo sapiens (Human) - SIPA1L1 gene Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). Taurus_UMD|evm.model.AC_000159.1.441 Q9JLY0 SOCS6_MOUSE 66.667 0.435185 0.810507 Socs6 - Suppressor of cytokine signaling 6 - Mus musculus (Mouse) - Socs6 gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity). Taurus_UMD|evm.model.AC_000159.1.442 Q78HU7 GLPC_MOUSE 77.586 0.518182 1.15789 Gypc - Glycophorin-C - Mus musculus (Mouse) - Gypc gene cortical cytoskeleton, membrane, plasma membrane Taurus_UMD|evm.model.AC_000159.1.444 A0A1B0GUA7 TEX51_HUMAN 48.235 0.597173 1.70482 TEX51 - Testis-expressed protein 51 precursor - Homo sapiens (Human) - TEX51 gene Taurus_UMD|evm.model.AC_000159.1.445 D3Z7P3 GLSK_MOUSE 94.535 0.997037 1.00148 Gls - Glutaminase kidney isoform, mitochondrial precursor - Mus musculus (Mouse) - Gls gene Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain. Taurus_UMD|evm.model.AC_000159.1.446 Q764M5 STAT1_PIG 97.181 0.964981 1.01849 STAT1 - Signal transducer and activator of transcription 1 - Sus scrofa (Pig) - STAT1 gene Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Taurus_UMD|evm.model.AC_000159.1.448 Q14765 STAT4_HUMAN 96.538 0.99734 1.00535 STAT4 - Signal transducer and activator of transcription 4 - Homo sapiens (Human) - STAT4 gene Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling. Taurus_UMD|evm.model.AC_000159.1.449 O43795 MYO1B_HUMAN 98.063 0.984389 1.01496 MYO1B - Unconventional myosin-Ib - Homo sapiens (Human) - MYO1B gene Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport. Taurus_UMD|evm.model.AC_000159.1.450 A5D7P8 SOSB2_BOVIN 100.000 0.990338 1.00485 NABP1 - SOSS complex subunit B2 - Bos taurus (Bovine) - NABP1 gene Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). Taurus_UMD|evm.model.AC_000159.1.451 O95810 CAVN2_HUMAN 87.042 0.99511 0.962353 CAVIN2 - Caveolae-associated protein 2 - Homo sapiens (Human) - CAVIN2 gene Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). Taurus_UMD|evm.model.AC_000159.1.453 Q9H607 OCEL1_HUMAN 86.408 0.744526 0.518939 OCEL1 - Occludin/ELL domain-containing protein 1 - Homo sapiens (Human) - OCEL1 gene Taurus_UMD|evm.model.AC_000159.1.455 Q10126 YSM6_CAEEL 24.299 0.6633 1.06452 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000159.1.457 Q10126 YSM6_CAEEL 31.313 0.373391 0.835125 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000159.1.458 Q29RK4 RD23B_BOVIN 76.961 0.993976 0.813725 RAD23B - UV excision repair protein RAD23 homolog B - Bos taurus (Bovine) - RAD23B gene Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome (By similarity). Taurus_UMD|evm.model.AC_000159.1.460 Q9ULF5 S39AA_HUMAN 92.317 0.997602 1.00361 SLC39A10 - Zinc transporter ZIP10 precursor - Homo sapiens (Human) - SLC39A10 gene May act as a zinc-influx transporter. Taurus_UMD|evm.model.AC_000159.1.461 Q8WXX0 DYH7_HUMAN 91.923 0.999502 0.997763 DNAH7 - Dynein axonemal heavy chain 7 - Homo sapiens (Human) - DNAH7 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Taurus_UMD|evm.model.AC_000159.1.462 O94768 ST17B_HUMAN 93.280 0.994638 1.00269 STK17B - Serine/threonine-protein kinase 17B - Homo sapiens (Human) - STK17B gene Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis. Taurus_UMD|evm.model.AC_000159.1.463 Q9P2P5 HECW2_HUMAN 99.343 0.989583 0.48855 HECW2 - E3 ubiquitin-protein ligase HECW2 - Homo sapiens (Human) - HECW2 gene E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). Taurus_UMD|evm.model.AC_000159.1.464 Q9P2P5 HECW2_HUMAN 90.577 0.90087 0.365776 HECW2 - E3 ubiquitin-protein ligase HECW2 - Homo sapiens (Human) - HECW2 gene E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). Taurus_UMD|evm.model.AC_000159.1.465 Q9P2P5 HECW2_HUMAN 99.322 0.993243 0.188295 HECW2 - E3 ubiquitin-protein ligase HECW2 - Homo sapiens (Human) - HECW2 gene E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). Taurus_UMD|evm.model.AC_000159.1.467 Q8NCX0 CC150_HUMAN 78.080 0.945822 0.989101 CCDC150 - Coiled-coil domain-containing protein 150 - Homo sapiens (Human) - CCDC150 gene Taurus_UMD|evm.model.AC_000159.1.468 Q9Y5Q9 TF3C3_HUMAN 93.002 0.997714 0.987585 GTF3C3 - General transcription factor 3C polypeptide 3 - Homo sapiens (Human) - GTF3C3 gene Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. Taurus_UMD|evm.model.AC_000159.1.469 Q75T13 PGAP1_HUMAN 92.516 0.997833 1.00108 PGAP1 - GPI inositol-deacylase - Homo sapiens (Human) - PGAP1 gene Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity). Taurus_UMD|evm.model.AC_000159.1.470 Q8N8A2 ANR44_HUMAN 97.155 0.918605 1.03927 ANKRD44 - Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B - Homo sapiens (Human) - ANKRD44 gene Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Taurus_UMD|evm.model.AC_000159.1.471 A8D8X1 RL10_SHEEP 83.544 0.975 0.373832 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000159.1.472 Q9NR23 GDF3_HUMAN 78.142 0.994521 1.00275 GDF3 - Growth/differentiation factor 3 precursor - Homo sapiens (Human) - GDF3 gene Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto (PubMed:21805089). Taurus_UMD|evm.model.AC_000159.1.473 O75533 SF3B1_HUMAN 99.923 0.944888 1.05752 SF3B1 - Splicing factor 3B subunit 1 - Homo sapiens (Human) - SF3B1 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). Taurus_UMD|evm.model.AC_000159.1.474 Q9H8M1 CQ10B_HUMAN 87.603 0.983673 1.02941 COQ10B - Coenzyme Q-binding protein COQ10 homolog B, mitochondrial precursor - Homo sapiens (Human) - COQ10B gene Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity). Taurus_UMD|evm.model.AC_000159.1.475 P31081 CH60_BOVIN 99.302 0.956522 1.04363 HSPD1 - 60 kDa heat shock protein, mitochondrial precursor - Bos taurus (Bovine) - HSPD1 gene Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein. Taurus_UMD|evm.model.AC_000159.1.477 P61604 CH10_HUMAN 100.000 0.980583 1.0098 HSPE1 - 10 kDa heat shock protein, mitochondrial - Homo sapiens (Human) - HSPE1 gene Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:7912672, PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). Taurus_UMD|evm.model.AC_000159.1.478 Q9QYW3 PHOCN_RAT 100.000 0.99115 1.00444 Mob4 - MOB-like protein phocein - Rattus norvegicus (Rat) - Mob4 gene May play a role in membrane trafficking, specifically in membrane budding reactions. Taurus_UMD|evm.model.AC_000159.1.479 Q52LD8 RFTN2_HUMAN 86.427 0.995992 0.996008 RFTN2 - Raftlin-2 - Homo sapiens (Human) - RFTN2 gene Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. Taurus_UMD|evm.model.AC_000159.1.480 A6H7E1 SYMM_BOVIN 100.000 0.996633 1.00169 MARS2 - Methionine--tRNA ligase, mitochondrial precursor - Bos taurus (Bovine) - MARS2 gene methionine-tRNA ligase activity, methionyl-tRNA aminoacylation Taurus_UMD|evm.model.AC_000159.1.481 Q924M5 BOLL_MOUSE 96.739 0.737265 1.3274 Boll - Protein boule-like - Mus musculus (Mouse) - Boll gene Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity). Taurus_UMD|evm.model.AC_000159.1.483 Q9UHD8 SEPT9_HUMAN 91.429 0.958333 0.122867 SEPTIN9 - Septin-9 - Homo sapiens (Human) - SEPTIN9 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. Taurus_UMD|evm.model.AC_000159.1.484 Q15111 PLCL1_HUMAN 96.752 0.995098 0.931507 PLCL1 - Inactive phospholipase C-like protein 1 - Homo sapiens (Human) - PLCL1 gene Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. Taurus_UMD|evm.model.AC_000159.1.486 Q9UPW6 SATB2_HUMAN 98.726 0.262185 0.811733 SATB2 - DNA-binding protein SATB2 - Homo sapiens (Human) - SATB2 gene Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Taurus_UMD|evm.model.AC_000159.1.488 E5RQL4 FONG_HUMAN 80.451 0.47482 1.89116 FTCDNL1 - Formiminotransferase N-terminal subdomain-containing protein precursor - Homo sapiens (Human) - FTCDNL1 gene Taurus_UMD|evm.model.AC_000159.1.489 Q8N8R5 CB069_HUMAN 88.462 0.994885 1.01558 C2orf69 - UPF0565 protein C2orf69 precursor - Homo sapiens (Human) - C2orf69 gene Taurus_UMD|evm.model.AC_000159.1.490 A2RUC4 TYW5_HUMAN 92.381 0.993671 1.00317 TYW5 - tRNA wybutosine-synthesizing protein 5 - Homo sapiens (Human) - TYW5 gene tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes. Taurus_UMD|evm.model.AC_000159.1.491 A3KN05 MAIP1_BOVIN 100.000 0.992509 0.917526 MAIP1 - m-AAA protease-interacting protein 1, mitochondrial precursor - Bos taurus (Bovine) - MAIP1 gene Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). Taurus_UMD|evm.model.AC_000159.1.492 P84232 H32_PORAF 99.265 0.985401 1.00735 Histone H3.2 - Poroderma africanum (Striped catshark) Taurus_UMD|evm.model.AC_000159.1.494 Q9NUQ6 SPS2L_HUMAN 94.040 0.292398 0.919355 SPATS2L - SPATS2-like protein - Homo sapiens (Human) - SPATS2L gene cytoplasm, cytosol, nucleolus, nucleoplasm, protein-containing complex, RNA binding Taurus_UMD|evm.model.AC_000159.1.495 Q29RJ0 KCD18_BOVIN 100.000 0.995272 1.00237 KCTD18 - BTB/POZ domain-containing protein KCTD18 - Bos taurus (Bovine) - KCTD18 gene Taurus_UMD|evm.model.AC_000159.1.496 P48034 AOXA_BOVIN 97.984 0.489456 2.01867 AOX1 - Aldehyde oxidase 1 - Bos taurus (Bovine) - AOX1 gene Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. Taurus_UMD|evm.model.AC_000159.1.497 D3ZKU7 BL1S1_RAT 72.800 0.968 1 Bloc1s1 - Biogenesis of lysosome-related organelles complex 1 subunit 1 - Rattus norvegicus (Rat) - Bloc1s1 gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. The BORC complex is most probably associated with the cytosolic face of lysosomes, may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Taurus_UMD|evm.model.AC_000159.1.498 Q3TYQ9 AOXD_MOUSE 82.565 0.998436 0.957335 Aox4 - Aldehyde oxidase 4 - Mus musculus (Mouse) - Aox4 gene Aldehyde oxidase able to catalyze the oxidation of retinaldehyde into retinoate. Is responsible for the major all-trans-retinaldehyde-metabolizing activity in the Harderian gland, and contributes a significant amount of the same activity in the skin. Is devoid of pyridoxal-oxidizing activity, in contrast to the other aldehyde oxidases. Acts as a negative modulator of the epidermal trophism. May be able to oxidize a wide variety of aldehydes into their corresponding carboxylates and to hydroxylate azaheterocycles. Taurus_UMD|evm.model.AC_000159.1.499 C4NYZ3 AOXB_MACFA 87.333 0.998505 0.991846 AOX2 - Aldehyde oxidase 2 - Macaca fascicularis (Crab-eating macaque) - AOX2 gene Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as phthalazine, as well as aldehydes, such as benzaldehyde and retinal. Taurus_UMD|evm.model.AC_000159.1.500 Q6P7P5 BZW1_RAT 100.000 0.924779 1.07876 Bzw1 - Basic leucine zipper and W2 domain-containing protein 1 - Rattus norvegicus (Rat) - Bzw1 gene Enhances histone H4 gene transcription but does not seem to bind DNA directly. Taurus_UMD|evm.model.AC_000159.1.501 P49759 CLK1_HUMAN 93.595 0.829897 1.20248 CLK1 - Dual specificity protein kinase CLK1 - Homo sapiens (Human) - CLK1 gene Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. Taurus_UMD|evm.model.AC_000159.1.502 Q9H2H8 PPIL3_HUMAN 99.259 0.978102 0.850932 PPIL3 - Peptidyl-prolyl cis-trans isomerase-like 3 - Homo sapiens (Human) - PPIL3 gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000159.1.503 Q05B89 NIF3L_BOVIN 100.000 0.994709 1.00265 NIF3L1 - NIF3-like protein 1 - Bos taurus (Bovine) - NIF3L1 gene May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation. Taurus_UMD|evm.model.AC_000159.1.504 A6QNM3 ORC2_BOVIN 99.653 0.99654 1.00173 ORC2 - Origin recognition complex subunit 2 - Bos taurus (Bovine) - ORC2 gene Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity). Taurus_UMD|evm.model.AC_000159.1.506 Q5R977 F126B_PONAB 86.860 0.996593 1.10755 FAM126B - Protein FAM126B - Pongo abelii (Sumatran orangutan) - FAM126B gene Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. Taurus_UMD|evm.model.AC_000159.1.507 Q02365 NDUB3_BOVIN 100.000 0.740458 1.33673 NDUFB3 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 - Bos taurus (Bovine) - NDUFB3 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000159.1.508 A5A6H4 ROA1_PANTR 90.164 0.36875 0.5 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Pan troglodytes (Chimpanzee) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. Taurus_UMD|evm.model.AC_000159.1.509 O15519 CFLAR_HUMAN 73.608 0.941406 1.06667 CFLAR - CASP8 and FADD-like apoptosis regulator precursor - Homo sapiens (Human) - CFLAR gene Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. Taurus_UMD|evm.model.AC_000159.1.510 Q92851 CASPA_HUMAN 62.500 0.868182 0.422265 CASP10 - Caspase-10 precursor - Homo sapiens (Human) - CASP10 gene Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Taurus_UMD|evm.model.AC_000159.1.511 Q14790 CASP8_HUMAN 70.722 0.99177 1.01461 CASP8 - Caspase-8 precursor - Homo sapiens (Human) - CASP8 gene Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (By similarity). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death (PubMed:23516580, PubMed:8681376, PubMed:8681377, PubMed:9006941, PubMed:9184224, PubMed:8962078). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:8962078, PubMed:9006941). Binding to the adapter molecule FADD recruits it to either receptor TNFRSF6/FAS mediated or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31827280, PubMed:31827281). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-D (GSDMD): GSDMD cleavage promoting release of the N-terminal moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis (By similarity). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (PubMed:8755496). Cleaves PARP1 (PubMed:8681376). Taurus_UMD|evm.model.AC_000159.1.512 Q96Q35 FACC1_HUMAN 70.337 0.995272 0.950562 FLACC1 - Flagellum-associated coiled-coil domain-containing protein 1 - Homo sapiens (Human) - FLACC1 gene cytoplasm, outer dense fiber, sperm fibrous sheath, sperm flagellum Taurus_UMD|evm.model.AC_000159.1.513 O60296 TRAK2_HUMAN 89.727 0.997812 1 TRAK2 - Trafficking kinesin-binding protein 2 - Homo sapiens (Human) - TRAK2 gene May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR. Taurus_UMD|evm.model.AC_000159.1.514 Q9C0K7 STRAB_HUMAN 94.258 0.995227 1.00239 STRADB - STE20-related kinase adapter protein beta - Homo sapiens (Human) - STRADB gene Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). Taurus_UMD|evm.model.AC_000159.1.515 Q53TS8 C2CD6_HUMAN 70.103 0.0525442 2.90209 C2CD6 - C2 calcium-dependent domain-containing protein 6 - Homo sapiens (Human) - C2CD6 gene Taurus_UMD|evm.model.AC_000159.1.516 E1BN97 TM237_BOVIN 100.000 0.96088 1.0225 TMEM237 - Transmembrane protein 237 - Bos taurus (Bovine) - TMEM237 gene Component of the transition zone in primary cilia. Required for ciliogenesis (By similarity). Taurus_UMD|evm.model.AC_000159.1.517 Q9QYH1 MPP4_RAT 83.691 0.909804 0.578231 Mpp4 - MAGUK p55 subfamily member 4 - Rattus norvegicus (Rat) - Mpp4 gene May play a role in retinal photoreceptors development. Taurus_UMD|evm.model.AC_000159.1.518 Q96JB8 MPP4_HUMAN 89.206 0.872222 0.565149 MPP4 - MAGUK p55 subfamily member 4 - Homo sapiens (Human) - MPP4 gene May play a role in retinal photoreceptors development. Taurus_UMD|evm.model.AC_000159.1.519 Q96Q42 ALS2_HUMAN 94.086 0.998793 1 ALS2 - Alsin - Homo sapiens (Human) - ALS2 gene May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). Taurus_UMD|evm.model.AC_000159.1.521 O75084 FZD7_HUMAN 97.038 0.996522 1.00174 FZD7 - Frizzled-7 precursor - Homo sapiens (Human) - FZD7 gene Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (PubMed:26126266). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Taurus_UMD|evm.model.AC_000159.1.522 A7YY35 K2012_BOVIN 85.175 0.979107 0.918047 KIAA2012 - Uncharacterized protein KIAA2012 homolog - Bos taurus (Bovine) - KIAA2012 gene Taurus_UMD|evm.model.AC_000159.1.523 Q5I0H3 SUMO1_RAT 100.000 0.478469 2.06931 Sumo1 - Small ubiquitin-related modifier 1 precursor - Rattus norvegicus (Rat) - Sumo1 gene Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3. Taurus_UMD|evm.model.AC_000159.1.524 Q4R779 NOP58_MACFA 94.991 0.996296 1.01887 NOP58 - Nucleolar protein 58 - Macaca fascicularis (Crab-eating macaque) - NOP58 gene Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (By similarity). Taurus_UMD|evm.model.AC_000159.1.525 O35607 BMPR2_MOUSE 94.709 0.664319 0.820809 Bmpr2 - Bone morphogenetic protein receptor type-2 precursor - Mus musculus (Mouse) - Bmpr2 gene On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6 (PubMed:23527555). Taurus_UMD|evm.model.AC_000159.1.526 Q6P1L5 F117B_HUMAN 97.429 0.960396 0.685908 FAM117B - Protein FAM117B - Homo sapiens (Human) - FAM117B gene Taurus_UMD|evm.model.AC_000159.1.527 Q8NDH6 ICA1L_HUMAN 84.058 0.977642 1.02075 ICA1L - Islet cell autoantigen 1-like protein - Homo sapiens (Human) - ICA1L gene Golgi apparatus, regulation of transport Taurus_UMD|evm.model.AC_000159.1.528 Q0VC24 WDR12_BOVIN 100.000 0.995283 1.00236 WDR12 - Ribosome biogenesis protein WDR12 - Bos taurus (Bovine) - WDR12 gene Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Taurus_UMD|evm.model.AC_000159.1.529 Q58CW6 CARTF_BOVIN 96.628 0.941595 0.998578 CARF - Calcium-responsive transcription factor - Bos taurus (Bovine) - CARF gene Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence (By similarity). Taurus_UMD|evm.model.AC_000159.1.530 Q6ZS30 NBEL1_HUMAN 92.799 0.999258 1 NBEAL1 - Neurobeachin-like protein 1 - Homo sapiens (Human) - NBEAL1 gene cytosol, membrane, protein kinase binding, protein localization Taurus_UMD|evm.model.AC_000159.1.531 Q5E980 CP20A_BOVIN 100.000 0.99568 1.00216 CYP20A1 - Cytochrome P450 20A1 - Bos taurus (Bovine) - CYP20A1 gene Taurus_UMD|evm.model.AC_000159.1.532 Q9NYB9 ABI2_HUMAN 92.251 0.996276 1.04678 ABI2 - Abl interactor 2 - Homo sapiens (Human) - ABI2 gene Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:7590236, PubMed:8649853, PubMed:10498863). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). Taurus_UMD|evm.model.AC_000159.1.533 Q70E73 RAPH1_HUMAN 89.213 0.540221 1.0144 RAPH1 - Ras-associated and pleckstrin homology domains-containing protein 1 - Homo sapiens (Human) - RAPH1 gene Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. Taurus_UMD|evm.model.AC_000159.1.534 Q28071 CD28_BOVIN 100.000 0.989637 0.881279 CD28 - T-cell-specific surface glycoprotein CD28 precursor - Bos taurus (Bovine) - CD28 gene Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Taurus_UMD|evm.model.AC_000159.1.535 Q9H175 CSRN2_HUMAN 87.395 0.690058 0.314917 CSRNP2 - Cysteine/serine-rich nuclear protein 2 - Homo sapiens (Human) - CSRNP2 gene Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis. Taurus_UMD|evm.model.AC_000159.1.536 Q9MYX7 CTLA4_PIG 89.785 0.989305 0.838565 CTLA4 - Cytotoxic T-lymphocyte protein 4 precursor - Sus scrofa (Pig) - CTLA4 gene Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Taurus_UMD|evm.model.AC_000159.1.537 Q58DF9 ICOS_BOVIN 98.995 0.758621 1.2488 ICOS - Inducible T-cell costimulator precursor - Bos taurus (Bovine) - ICOS gene Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). Taurus_UMD|evm.model.AC_000159.1.539 P61314 RL15_RAT 99.510 0.990244 1.0049 Rpl15 - 60S ribosomal protein L15 - Rattus norvegicus (Rat) - Rpl15 gene A band, cytosolic large ribosomal subunit, nucleus, RNA binding, structural constituent of ribosome, cytoplasmic translation, response to ethanol Taurus_UMD|evm.model.AC_000159.1.541 Q8TEW8 PAR3L_HUMAN 91.689 0.998232 0.938589 PARD3B - Partitioning defective 3 homolog B - Homo sapiens (Human) - PARD3B gene Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. Taurus_UMD|evm.model.AC_000159.1.542 O60462 NRP2_HUMAN 96.539 0.895787 0.968851 NRP2 - Neuropilin-2 precursor - Homo sapiens (Human) - NRP2 gene High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. Taurus_UMD|evm.model.AC_000159.1.543 O60462 NRP2_HUMAN 94.167 0.908397 0.140709 NRP2 - Neuropilin-2 precursor - Homo sapiens (Human) - NRP2 gene High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. Taurus_UMD|evm.model.AC_000159.1.544 Q53TQ3 IN80D_HUMAN 96.397 0.998053 1 INO80D - INO80 complex subunit D - Homo sapiens (Human) - INO80D gene Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Taurus_UMD|evm.model.AC_000159.1.545 P15690 NDUS1_BOVIN 100.000 0.997253 1.00138 NDUFS1 - NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor - Bos taurus (Bovine) - NDUFS1 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:10852722, PubMed:18721790). Essential for catalysing the entry and efficient transfer of electrons within complex I (By similarity). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity). Taurus_UMD|evm.model.AC_000159.1.546 Q5E983 EF1B_BOVIN 100.000 0.99115 1.00444 EEF1B - Elongation factor 1-beta - Bos taurus (Bovine) - EEF1B gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Taurus_UMD|evm.model.AC_000159.1.547 P46091 GPR1_HUMAN 87.887 0.994382 1.00282 GPR1 - G-protein coupled receptor 1 - Homo sapiens (Human) - GPR1 gene Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (PubMed:18165312). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). Taurus_UMD|evm.model.AC_000159.1.548 Q9HCK1 ZDBF2_HUMAN 51.672 0.966069 0.876381 ZDBF2 - DBF4-type zinc finger-containing protein 2 - Homo sapiens (Human) - ZDBF2 gene Taurus_UMD|evm.model.AC_000159.1.549 O75077 ADA23_HUMAN 94.118 0.997602 1.0024 ADAM23 - Disintegrin and metalloproteinase domain-containing protein 23 precursor - Homo sapiens (Human) - ADAM23 gene May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein. Taurus_UMD|evm.model.AC_000159.1.550 A0A1B0GTK4 F237A_HUMAN 85.915 0.886792 0.878453 FAM237A - Protein FAM237A - Homo sapiens (Human) - FAM237A gene Taurus_UMD|evm.model.AC_000159.1.551 A2CI98 DYTN_MOUSE 67.273 0.508349 0.825421 Dytn - Dystrotelin - Mus musculus (Mouse) - Dytn gene plasma membrane, synaptic signaling Taurus_UMD|evm.model.AC_000159.1.552 A3KMX7 MDH1B_BOVIN 100.000 0.89675 1.10571 MDH1B - Putative malate dehydrogenase 1B - Bos taurus (Bovine) - MDH1B gene L-malate dehydrogenase activity, malate metabolic process, NADH metabolic process, oxaloacetate metabolic process, tricarboxylic acid cycle Taurus_UMD|evm.model.AC_000159.1.553 Q9NYY8 FAKD2_HUMAN 70.529 0.995646 0.970423 FASTKD2 - FAST kinase domain-containing protein 2, mitochondrial precursor - Homo sapiens (Human) - FASTKD2 gene Plays an important role in assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664, PubMed:25683715, PubMed:26370583). May play a role in mitochondrial apoptosis. Taurus_UMD|evm.model.AC_000159.1.554 Q0II73 CBPO_BOVIN 100.000 0.994681 1.00267 CPO - Carboxypeptidase O precursor - Bos taurus (Bovine) - CPO gene Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues. Taurus_UMD|evm.model.AC_000159.1.555 O75840 KLF7_HUMAN 97.020 0.993399 1.00331 KLF7 - Krueppel-like factor 7 - Homo sapiens (Human) - KLF7 gene Transcriptional factor (PubMed:9774444, PubMed:16339272). Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity). Represses the corneal epithelium differentiation (PubMed:28916725). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272). Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272). Taurus_UMD|evm.model.AC_000159.1.556 Q2HJE9 TI17B_BOVIN 51.163 0.980583 0.598837 TIMM17B - Mitochondrial import inner membrane translocase subunit Tim17-B - Bos taurus (Bovine) - TIMM17B gene Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Taurus_UMD|evm.model.AC_000159.1.557 P27925 CREB1_BOVIN 95.870 0.988304 1.05231 CREB1 - Cyclic AMP-responsive element-binding protein 1 - Bos taurus (Bovine) - CREB1 gene Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-117 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. Taurus_UMD|evm.model.AC_000159.1.558 A4FV42 MT21A_BOVIN 100.000 0.990868 1.00459 METTL21A - Protein N-lysine methyltransferase METTL21A - Bos taurus (Bovine) - METTL21A gene Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8 (By similarity). Taurus_UMD|evm.model.AC_000159.1.559 Q8BR07 BICD1_MOUSE 89.394 0.492188 0.153293 Bicd1 - Protein bicaudal D homolog 1 - Mus musculus (Mouse) - Bicd1 gene Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. Taurus_UMD|evm.model.AC_000159.1.560 Q8N7R7 CCYL1_HUMAN 93.388 0.994505 1.01393 CCNYL1 - Cyclin-Y-like protein 1 - Homo sapiens (Human) - CCNYL1 gene cytoplasm, plasma membrane, cyclin-dependent protein serine/threonine kinase regulator activity, positive regulation of cyclin-dependent protein serine/threonine kinase activity Taurus_UMD|evm.model.AC_000159.1.561 Q13467 FZD5_HUMAN 96.752 0.996587 1.00171 FZD5 - Frizzled-5 precursor - Homo sapiens (Human) - FZD5 gene Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). Taurus_UMD|evm.model.AC_000159.1.562 Q6ZWE6 PKHM3_HUMAN 90.276 0.997358 0.994744 PLEKHM3 - Pleckstrin homology domain-containing family M member 3 - Homo sapiens (Human) - PLEKHM3 gene Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation. Taurus_UMD|evm.model.AC_000159.1.564 P23005 CRGF_BOVIN 95.977 0.988571 1.00575 CRYGF - Gamma-crystallin F - Bos taurus (Bovine) - CRYGF gene Crystallins are the dominant structural components of the vertebrate eye lens. Taurus_UMD|evm.model.AC_000159.1.565 P62986 RL40_RAT 79.646 0.982143 0.875 Uba52 - Ubiquitin-60S ribosomal protein L40 precursor - Rattus norvegicus (Rat) - Uba52 gene Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). Taurus_UMD|evm.model.AC_000159.1.566 P08209 CRGD_BOVIN 99.425 0.988571 1.00575 CRYGD - Gamma-crystallin D - Bos taurus (Bovine) - CRYGD gene Crystallins are the dominant structural components of the vertebrate eye lens. Taurus_UMD|evm.model.AC_000159.1.567 Q28088 CRGC_BOVIN 99.419 0.5 1.96552 CRYGC - Gamma-crystallin C - Bos taurus (Bovine) - CRYGC gene Crystallins are the dominant structural components of the vertebrate eye lens. Taurus_UMD|evm.model.AC_000159.1.568 P10065 CRGA_RAT 90.805 0.988571 1.00575 Cryga - Gamma-crystallin A - Rattus norvegicus (Rat) - Cryga gene Crystallins are the dominant structural components of the vertebrate eye lens. Taurus_UMD|evm.model.AC_000159.1.569 Q0P641 CB080_HUMAN 80.412 0.989744 1.01036 C2orf80 - Uncharacterized protein C2orf80 - Homo sapiens (Human) - C2orf80 gene Taurus_UMD|evm.model.AC_000159.1.570 Q9XSG3 IDHC_BOVIN 99.758 0.995181 1.00242 IDH1 - Isocitrate dehydrogenase [NADP] cytoplasmic - Bos taurus (Bovine) - IDH1 gene May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency. Taurus_UMD|evm.model.AC_000159.1.571 Q9Y2I7 FYV1_HUMAN 94.757 0.996673 1.00286 PIKFYVE - 1-phosphatidylinositol 3-phosphate 5-kinase - Homo sapiens (Human) - PIKFYVE gene Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation downregulates lipid product formation (By similarity). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, trhough association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). Taurus_UMD|evm.model.AC_000159.1.572 Q8N5Y2 MS3L1_HUMAN 91.268 0.994382 0.683301 MSL3 - Male-specific lethal 3 homolog - Homo sapiens (Human) - MSL3 gene Has a role in chromatin remodeling and transcriptional regulation (PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647). Has a role in X inactivation (PubMed:21217699). Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure (PubMed:16227571, PubMed:20657587, PubMed:16543150, PubMed:30224647). Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). Taurus_UMD|evm.model.AC_000159.1.573 P49190 PTH2R_HUMAN 90.937 0.681818 0.88 PTH2R - Parathyroid hormone 2 receptor precursor - Homo sapiens (Human) - PTH2R gene This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity). Taurus_UMD|evm.model.AC_000159.1.575 P23005 CRGF_BOVIN 100.000 0.988571 1.00575 CRYGF - Gamma-crystallin F - Bos taurus (Bovine) - CRYGF gene Crystallins are the dominant structural components of the vertebrate eye lens. Taurus_UMD|evm.model.AC_000159.1.576 P15146 MTAP2_RAT 96.286 0.695219 0.269747 Map2 - Microtubule-associated protein 2 - Rattus norvegicus (Rat) - Map2 gene The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. Taurus_UMD|evm.model.AC_000159.1.577 Q8N2C7 UNC80_HUMAN 97.592 0.999562 0.70043 UNC80 - Protein unc-80 homolog - Homo sapiens (Human) - UNC80 gene Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium. Taurus_UMD|evm.model.AC_000159.1.578 Q8VEE0 RPE_MOUSE 97.561 0.5 0.350877 Rpe - Ribulose-phosphate 3-epimerase - Mus musculus (Mouse) - Rpe gene Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. Taurus_UMD|evm.model.AC_000159.1.579 Q8VEE0 RPE_MOUSE 96.257 0.180407 4.52193 Rpe - Ribulose-phosphate 3-epimerase - Mus musculus (Mouse) - Rpe gene Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. Taurus_UMD|evm.model.AC_000159.1.580 P79274 ACADL_PIG 85.581 0.995261 0.981395 ACADL - Long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor - Sus scrofa (Pig) - ACADL gene Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (By similarity). Taurus_UMD|evm.model.AC_000159.1.581 P70617 NINJ1_RAT 87.500 0.986842 1 Ninj1 - Ninjurin-1 - Rattus norvegicus (Rat) - Ninj1 gene Homophilic transmembrane adhesion molecule involved in various processes such as inflammation, cell death, axonal growth, cell chemotaxis and angiogenesis (By similarity). Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM) (PubMed:19595672). Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells (By similarity). Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding (By similarity). Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions (By similarity). Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS (By similarity). Acts as a mediator of both programmed and necrotic cell death (By similarity). Plays a key role in the induction of plasma membrane rupture during programmed and necrotic cell death: oligomerizes in response to death stimuli to mediate plasma membrane rupture (cytolysis), leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (By similarity). Plays a role in nerve regeneration by promoting maturation of Schwann cells (By similarity). Acts as a regulator of angiogenesis (PubMed:33028854). Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells (By similarity). Promotes osteoclasts development by enhancing the survival of prefusion osteoclasts (By similarity). Also involved in striated muscle growth and differentiation (By similarity). Taurus_UMD|evm.model.AC_000159.1.582 A0JNJ5 MYL1_BOVIN 100.000 0.989637 1.00521 MYL1 - Myosin light chain 1/3, skeletal muscle isoform - Bos taurus (Bovine) - MYL1 gene Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. Taurus_UMD|evm.model.AC_000159.1.583 F1MVX2 LANC1_BOVIN 100.000 0.837895 1.19048 LANCL1 - Glutathione S-transferase LANCL1 - Bos taurus (Bovine) - LANCL1 gene Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling (By similarity). Binds glutathione (PubMed:17305318). Taurus_UMD|evm.model.AC_000159.1.584 P31327 CPSM_HUMAN 95.060 0.997335 1.00067 CPS1 - Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor - Homo sapiens (Human) - CPS1 gene Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. Taurus_UMD|evm.model.AC_000159.1.585 Q61527 ERBB4_MOUSE 94.800 0.992032 0.191896 Erbb4 - Receptor tyrosine-protein kinase erbB-4 precursor - Mus musculus (Mouse) - Erbb4 gene Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. Taurus_UMD|evm.model.AC_000159.1.586 Q61527 ERBB4_MOUSE 99.070 0.963964 0.169725 Erbb4 - Receptor tyrosine-protein kinase erbB-4 precursor - Mus musculus (Mouse) - Erbb4 gene Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. Taurus_UMD|evm.model.AC_000159.1.587 Q15303 ERBB4_HUMAN 94.137 0.989601 0.441131 ERBB4 - Receptor tyrosine-protein kinase erbB-4 precursor - Homo sapiens (Human) - ERBB4 gene Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. Taurus_UMD|evm.model.AC_000159.1.588 B2KIK3 UBL4A_RHIFE 88.050 0.796954 1.23125 UBL4A - Ubiquitin-like protein 4A - Rhinolophus ferrumequinum (Greater horseshoe bat) - UBL4A gene As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. Taurus_UMD|evm.model.AC_000159.1.589 Q15303 ERBB4_HUMAN 100.000 0.98 0.0382263 ERBB4 - Receptor tyrosine-protein kinase erbB-4 precursor - Homo sapiens (Human) - ERBB4 gene Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. Taurus_UMD|evm.model.AC_000159.1.590 Q53H47 SETMR_HUMAN 38.596 0.888889 0.0921053 SETMAR - Histone-lysine N-methyltransferase SETMAR - Homo sapiens (Human) - SETMAR gene Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750). Taurus_UMD|evm.model.AC_000159.1.592 Q16478 GRIK5_HUMAN 81.034 0.666667 0.0795918 GRIK5 - Glutamate receptor ionotropic, kainate 5 precursor - Homo sapiens (Human) - GRIK5 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD. Taurus_UMD|evm.model.AC_000159.1.593 Q9UKS7 IKZF2_HUMAN 99.430 0.986842 1.01141 IKZF2 - Zinc finger protein Helios - Homo sapiens (Human) - IKZF2 gene Associates with Ikaros at centromeric heterochromatin. Taurus_UMD|evm.model.AC_000159.1.595 Q95K75 VWC2L_MACFA 99.231 0.638614 1.46377 VWC2L - von Willebrand factor C domain-containing protein 2-like precursor - Macaca fascicularis (Crab-eating macaque) - VWC2L gene May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization. Taurus_UMD|evm.model.AC_000159.1.596 Q99728 BARD1_HUMAN 75.938 0.992958 0.913771 BARD1 - BRCA1-associated RING domain protein 1 - Homo sapiens (Human) - BARD1 gene E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. Taurus_UMD|evm.model.AC_000159.1.597 Q03274 PO22_POPJA 32.143 0.352564 0.438819 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 - Popillia japonica (Japanese beetle) Taurus_UMD|evm.model.AC_000159.1.598 Q86UK0 ABCAC_HUMAN 89.339 0.986791 0.991908 ABCA12 - Glucosylceramide transporter ABCA12 - Homo sapiens (Human) - ABCA12 gene Transports lipids such as glucosylceramides from the outer to the inner leaflet of lamellar granules (LGs) membrane, whereby the lipids are finally transported to the keratinocyte periphery via the trans-Golgi network and LGs and released to the apical surface of the granular keratinocytes to form lipid lamellae in the stratum corneum of the epidermis, which is essential for skin barrier function (PubMed:16007253, PubMed:20869849). In the mean time, participates in the transport of the lamellar granules-associated proteolytic enzymes, in turns regulates desquamation and keratinocyte differentiation (PubMed:19179616). Furthermore, is essential for the regulation of cellular cholesterol homeostasis by regulating ABCA1-dependent cholesterol efflux from macrophages through interaction with NR1H2 and ABCA1 (By similarity). Plays pleiotropic roles in regulating glucose stimulated insulin secretion from beta cells, regulating the morphology and fusion of insulin granules, lipid raft abundance and the actin cytoskeleton (By similarity). Also involved in lung surfactant biogenesis (By similarity). Taurus_UMD|evm.model.AC_000159.1.599 Q0VCK0 PUR9_BOVIN 100.000 0.996627 1.00169 ATIC - Bifunctional purine biosynthesis protein ATIC - Bos taurus (Bovine) - ATIC gene Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization. Taurus_UMD|evm.model.AC_000159.1.600 P07589 FINC_BOVIN 99.919 0.999193 1.0004 FN1 - Fibronectin precursor - Bos taurus (Bovine) - FN1 gene Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Taurus_UMD|evm.model.AC_000159.1.601 Q8N565 MREG_HUMAN 88.785 0.990698 1.00467 MREG - Melanoregulin - Homo sapiens (Human) - MREG gene Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity). Taurus_UMD|evm.model.AC_000159.1.602 Q9BY49 PECR_HUMAN 77.076 0.980392 1.0099 PECR - Peroxisomal trans-2-enoyl-CoA reductase - Homo sapiens (Human) - PECR gene Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity. Taurus_UMD|evm.model.AC_000159.1.603 Q2TBG9 TM169_BOVIN 100.000 0.993289 1.00337 TMEM169 - Transmembrane protein 169 - Bos taurus (Bovine) - TMEM169 gene Taurus_UMD|evm.model.AC_000159.1.604 P27641 XRCC5_MOUSE 77.353 0.997093 0.939891 Xrcc5 - X-ray repair cross-complementing protein 5 - Mus musculus (Mouse) - Xrcc5 gene Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription. As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome. Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Taurus_UMD|evm.model.AC_000159.1.605 Q9P2E8 MARH4_HUMAN 92.802 0.943902 1 MARCHF4 - E3 ubiquitin-protein ligase MARCHF4 precursor - Homo sapiens (Human) - MARCHF4 gene E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Taurus_UMD|evm.model.AC_000159.1.607 Q9TTA5 SMAL1_BOVIN 95.085 0.920039 1.07766 SMARCAL1 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 - Bos taurus (Bovine) - SMARCAL1 gene ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks (By similarity). Taurus_UMD|evm.model.AC_000159.1.608 P61515 RL37P_RAT 100.000 0.978495 1.01087 Rpl37a-ps1 - Putative 60S ribosomal protein L37a - Rattus norvegicus (Rat) - Rpl37a-ps1 gene Taurus_UMD|evm.model.AC_000159.1.609 P13384 IBP2_BOVIN 98.077 0.591954 0.548896 IGFBP2 - Insulin-like growth factor-binding protein 2 precursor - Bos taurus (Bovine) - IGFBP2 gene Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Taurus_UMD|evm.model.AC_000159.1.610 Q05717 IBP5_BOVIN 100.000 0.992647 1.00369 IGFBP5 - Insulin-like growth factor-binding protein 5 precursor - Bos taurus (Bovine) - IGFBP5 gene IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Taurus_UMD|evm.model.AC_000159.1.611 P17305 STP1_BOVIN 100.000 0.964286 1.01818 TNP1 - Spermatid nuclear transition protein 1 - Bos taurus (Bovine) - TNP1 gene Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Taurus_UMD|evm.model.AC_000159.1.615 Q9GLM4 TENS1_BOVIN 97.282 0.93079 1.06997 TNS1 - Tensin-1 - Bos taurus (Bovine) - TNS1 gene Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. Taurus_UMD|evm.model.AC_000159.1.617 Q28003 CXCR2_BOVIN 89.685 0.352227 2.74444 CXCR2 - C-X-C chemokine receptor type 2 - Bos taurus (Bovine) - CXCR2 gene Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). Taurus_UMD|evm.model.AC_000159.1.618 Q28003 CXCR2_BOVIN 99.167 0.99446 1.00278 CXCR2 - C-X-C chemokine receptor type 2 - Bos taurus (Bovine) - CXCR2 gene Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). Taurus_UMD|evm.model.AC_000159.1.619 Q3MHR7 ARPC2_BOVIN 100.000 0.993355 1.00333 ARPC2 - Actin-related protein 2/3 complex subunit 2 - Bos taurus (Bovine) - ARPC2 gene Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Taurus_UMD|evm.model.AC_000159.1.620 Q862A9 GPBAR_BOVIN 100.000 0.993939 1.00304 GPBAR1 - G-protein coupled bile acid receptor 1 - Bos taurus (Bovine) - GPBAR1 gene Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity). Taurus_UMD|evm.model.AC_000159.1.621 Q3SZK1 AAMP_BOVIN 99.770 0.995413 1.00461 AAMP - Angio-associated migratory cell protein - Bos taurus (Bovine) - AAMP gene Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. Taurus_UMD|evm.model.AC_000159.1.622 A7YY46 PNKD_BOVIN 80.198 0.699301 0.371429 PNKD - Probable hydrolase PNKD - Bos taurus (Bovine) - PNKD gene Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. Taurus_UMD|evm.model.AC_000159.1.623 Q969X1 LFG3_HUMAN 85.209 0.993528 0.993569 TMBIM1 - Protein lifeguard 3 - Homo sapiens (Human) - TMBIM1 gene Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling. Taurus_UMD|evm.model.AC_000159.1.624 A7YY46 PNKD_BOVIN 100.000 0.844875 0.937662 PNKD - Probable hydrolase PNKD - Bos taurus (Bovine) - PNKD gene Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. Taurus_UMD|evm.model.AC_000159.1.625 Q7Z7H3 CATIP_HUMAN 78.892 0.984375 0.992248 CATIP - Ciliogenesis-associated TTC17-interacting protein - Homo sapiens (Human) - CATIP gene Plays a role in primary ciliogenesis by modulating actin polymerization. Taurus_UMD|evm.model.AC_000159.1.626 Q27981 NRAM1_BOVIN 99.818 0.957968 1.04197 SLC11A1 - Natural resistance-associated macrophage protein 1 - Bos taurus (Bovine) - SLC11A1 gene Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (By similarity). Taurus_UMD|evm.model.AC_000159.1.629 Q9GZU7 CTDS1_HUMAN 98.851 0.992366 1.00383 CTDSP1 - Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 - Homo sapiens (Human) - CTDSP1 gene Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Taurus_UMD|evm.model.AC_000159.1.630 Q3SZP7 VILI_BOVIN 99.879 0.997585 1.00121 VIL1 - Villin-1 - Bos taurus (Bovine) - VIL1 gene Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair (By similarity). Taurus_UMD|evm.model.AC_000159.1.631 F1N5V1 UBP37_BOVIN 100.000 0.997963 1.00102 USP37 - Ubiquitin carboxyl-terminal hydrolase 37 - Bos taurus (Bovine) - USP37 gene Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1. Taurus_UMD|evm.model.AC_000159.1.632 P21671 PLCD4_BOVIN 95.219 0.734244 1.20354 PLCD4 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 - Bos taurus (Bovine) - PLCD4 gene Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation (By similarity). Taurus_UMD|evm.model.AC_000159.1.633 P52746 ZN142_HUMAN 85.250 0.840131 1.0901 ZNF142 - Zinc finger protein 142 - Homo sapiens (Human) - ZNF142 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000159.1.634 Q5E9H5 BCS1_BOVIN 100.000 0.995238 1.00239 BCS1L - Mitochondrial chaperone BCS1 - Bos taurus (Bovine) - BCS1L gene Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (By similarity). Taurus_UMD|evm.model.AC_000159.1.635 Q5E9N3 RNF25_BOVIN 99.346 0.995652 1.00437 RNF25 - E3 ubiquitin-protein ligase RNF25 - Bos taurus (Bovine) - RNF25 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2. Stimulates transcription mediated by NF-kappa-B. Taurus_UMD|evm.model.AC_000159.1.636 Q9NRP7 STK36_HUMAN 88.280 0.99772 1.00076 STK36 - Serine/threonine-protein kinase 36 - Homo sapiens (Human) - STK36 gene Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia. Taurus_UMD|evm.model.AC_000159.1.637 Q14679 TTLL4_HUMAN 81.266 0.995833 1.00083 TTLL4 - Tubulin polyglutamylase TTLL4 - Homo sapiens (Human) - TTLL4 gene Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Involved in formation of short side-chains. Mediates initiation of polyglutamylation of nucleosome assembly proteins NAP1L1 and NAP1L4. Also acts as a monoglutamylase: generates monoglutamylation of CGAS, leading to impair the nucleotidyltransferase activity of CGAS. Taurus_UMD|evm.model.AC_000159.1.638 P17177 CP27A_RABIT 78.652 0.988848 1.00561 CYP27A1 - Sterol 26-hydroxylase, mitochondrial precursor - Oryctolagus cuniculus (Rabbit) - CYP27A1 gene Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid (By similarity). Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the 'neutral' (classic) and the 'acid' (alternative) pathways (PubMed:2722778). May also regulate cholesterol homeostasis via generation of active oxysterols, which act as ligands for NR1H2 and NR1H3 nuclear receptors, modulating the transcription of genes involved in lipid metabolism. Plays a role in cholestanol metabolism in the cerebellum. Similarly to cholesterol, hydroxylates cholestanol and may facilitate sterol diffusion through the blood-brain barrier to the systemic circulation for further degradation. Also hydroxylates retinal 7-ketocholesterol, a noxious oxysterol with pro-inflammatory and pro-apoptotic effects, and may play a role in its elimination from the retinal pigment epithelium. May play a redundant role in vitamin D biosynthesis. Catalyzes 25-hydroxylation of vitamin D3 that is required for its conversion to a functionally active form (By similarity). Taurus_UMD|evm.model.AC_000159.1.639 Q2LL38 AAKG3_BOVIN 98.793 0.995935 0.98994 PRKAG3 - 5'-AMP-activated protein kinase subunit gamma-3 - Bos taurus (Bovine) - PRKAG3 gene AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (By similarity). Taurus_UMD|evm.model.AC_000159.1.640 Q9Y6F9 WNT6_HUMAN 97.808 0.994536 1.00274 WNT6 - Protein Wnt-6 precursor - Homo sapiens (Human) - WNT6 gene Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway. Taurus_UMD|evm.model.AC_000159.1.641 Q9GZT5 WN10A_HUMAN 95.444 0.995215 1.0024 WNT10A - Protein Wnt-10a precursor - Homo sapiens (Human) - WNT10A gene Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development (PubMed:17847007, PubMed:28589954). Required for normal tooth development (PubMed:17847007, PubMed:29178643, PubMed:28589954). Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed:28589954). Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity). Required for normal expression of KRT9 in foot plant epithelium (PubMed:28589954). Required for normal hair follicle function (PubMed:28589954). Taurus_UMD|evm.model.AC_000159.1.642 Q13319 CD5R2_HUMAN 95.174 0.994652 1.01907 CDK5R2 - Cyclin-dependent kinase 5 activator 2 precursor - Homo sapiens (Human) - CDK5R2 gene Activator of CDK5/TPKII. Taurus_UMD|evm.model.AC_000159.1.643 Q99581 FEV_HUMAN 97.083 0.991667 1.0084 FEV - Protein FEV - Homo sapiens (Human) - FEV gene Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. Taurus_UMD|evm.model.AC_000159.1.644 P26444 CRBA2_BOVIN 100.000 0.989899 1.00508 CRYBA2 - Beta-crystallin A2 - Bos taurus (Bovine) - CRYBA2 gene Crystallins are the dominant structural components of the vertebrate eye lens. Taurus_UMD|evm.model.AC_000159.1.646 Q3V0B4 CFA65_MOUSE 72.256 0.447514 0.979968 Cfap65 - Cilia- and flagella-associated protein 65 - Mus musculus (Mouse) - Cfap65 gene Plays a role in flagellar formation and sperm motility. Taurus_UMD|evm.model.AC_000159.1.647 Q14623 IHH_HUMAN 96.602 0.995157 1.00487 IHH - Indian hedgehog protein precursor - Homo sapiens (Human) - IHH gene Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity). Taurus_UMD|evm.model.AC_000159.1.648 Q9H9Q4 NHEJ1_HUMAN 88.889 0.9801 0.672241 NHEJ1 - Non-homologous end-joining factor 1 - Homo sapiens (Human) - NHEJ1 gene DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17470781). Binds DNA in a length-dependent manner (PubMed:17317666). Taurus_UMD|evm.model.AC_000159.1.649 Q6PIS1 S23A3_HUMAN 79.967 0.990148 0.998361 SLC23A3 - Solute carrier family 23 member 3 - Homo sapiens (Human) - SLC23A3 gene Taurus_UMD|evm.model.AC_000159.1.650 Q5E9J2 CNPD1_BOVIN 99.757 0.995146 1.00243 CNPPD1 - Protein CNPPD1 - Bos taurus (Bovine) - CNPPD1 gene cyclin-dependent protein kinase holoenzyme complex, nucleus, cyclin-dependent protein serine/threonine kinase regulator activity, regulation of cyclin-dependent protein serine/threonine kinase activity Taurus_UMD|evm.model.AC_000159.1.651 Q8NC44 RETR2_HUMAN 91.566 0.915129 0.998158 RETREG2 - Reticulophagy regulator 2 - Homo sapiens (Human) - RETREG2 gene integral component of membrane Taurus_UMD|evm.model.AC_000159.1.652 Q4KLG9 ZFN2B_RAT 91.085 0.992278 1.00778 Zfand2b - AN1-type zinc finger protein 2B precursor - Rattus norvegicus (Rat) - Zfand2b gene Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Taurus_UMD|evm.model.AC_000159.1.653 Q9NP58 ABCB6_HUMAN 89.180 0.995261 1.00238 ABCB6 - ATP-binding cassette sub-family B member 6 - Homo sapiens (Human) - ABCB6 gene ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen (PubMed:33007128, PubMed:27507172, PubMed:17661442, PubMed:23792964). May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turns may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress (PubMed:17006453, PubMed:10837493, PubMed:23792964, PubMed:33007128). May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils (PubMed:29940187). In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin (PubMed:25202056, PubMed:21266531, PubMed:31053883). In addition may play a role in the transition metal homeostasis (By similarity). Taurus_UMD|evm.model.AC_000159.1.654 Q3T904 ATG9A_BOVIN 99.285 0.997611 0.997616 ATG9A - Autophagy-related protein 9A - Bos taurus (Bovine) - ATG9A gene Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity). Taurus_UMD|evm.model.AC_000159.1.655 Q58CQ5 ANKZ1_BOVIN 100.000 0.997257 1.00137 ANKZF1 - Ankyrin repeat and zinc finger domain-containing protein 1 - Bos taurus (Bovine) - ANKZF1 gene Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity). Taurus_UMD|evm.model.AC_000159.1.656 Q6UWU2 GLB1L_HUMAN 86.392 0.964506 0.990826 GLB1L - Beta-galactosidase-1-like protein precursor - Homo sapiens (Human) - GLB1L gene Probable glycosyl hydrolase. Taurus_UMD|evm.model.AC_000159.1.657 O75716 STK16_HUMAN 92.131 0.993464 1.00328 STK16 - Serine/threonine-protein kinase 16 - Homo sapiens (Human) - STK16 gene Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. Taurus_UMD|evm.model.AC_000159.1.658 Q5XIF6 TBA4A_RAT 100.000 0.995546 1.00223 Tuba4a - Tubulin alpha-4A chain - Rattus norvegicus (Rat) - Tuba4a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Taurus_UMD|evm.model.AC_000159.1.659 Q2HJ86 TBA1D_BOVIN 100.000 0.995585 1.00221 TUBA1D - Tubulin alpha-1D chain - Bos taurus (Bovine) - TUBA1D gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Taurus_UMD|evm.model.AC_000159.1.660 P25686 DNJB2_HUMAN 95.636 0.982079 0.861111 DNAJB2 - DnaJ homolog subfamily B member 2 precursor - Homo sapiens (Human) - DNAJB2 gene Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). Taurus_UMD|evm.model.AC_000159.1.661 P56722 PTPRN_BOVIN 100.000 0.997959 1.00102 PTPRN - Receptor-type tyrosine-protein phosphatase-like N precursor - Bos taurus (Bovine) - PTPRN gene Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. Seems to lack intrinsic enzyme activity. May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization. Taurus_UMD|evm.model.AC_000159.1.662 A0JNL8 RES18_BOVIN 100.000 0.988571 1.00575 RESP18 - Regulated endocrine-specific protein 18 precursor - Bos taurus (Bovine) - RESP18 gene May play an important regulatory role in corticotrophs. Taurus_UMD|evm.model.AC_000159.1.663 Q2HJH1 DNPEP_BOVIN 100.000 0.921569 1.0828 DNPEP - Aspartyl aminopeptidase - Bos taurus (Bovine) - DNPEP gene Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism (By similarity). Taurus_UMD|evm.model.AC_000159.1.664 O62654 DESM_BOVIN 100.000 0.995754 1.00213 DES - Desmin - Bos taurus (Bovine) - DES gene Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin. Taurus_UMD|evm.model.AC_000159.1.665 Q15772 SPEG_HUMAN 91.710 0.999391 1.00459 SPEG - Striated muscle preferentially expressed protein kinase - Homo sapiens (Human) - SPEG gene Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. Taurus_UMD|evm.model.AC_000159.1.666 I3LUP1 GMPPA_PIG 97.143 0.586014 1.70238 GMPPA - Mannose-1-phosphate guanyltransferase alpha - Sus scrofa (Pig) - GMPPA gene May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose. Taurus_UMD|evm.model.AC_000159.1.667 Q7TNS7 ASIC4_MOUSE 98.077 0.655899 1.32096 Asic4 - Acid-sensing ion channel 4 - Mus musculus (Mouse) - Asic4 gene Probable cation channel with high affinity for sodium. Taurus_UMD|evm.model.AC_000159.1.668 Q8IZ52 CHSS2_HUMAN 95.613 0.997423 1.00129 CHPF - Chondroitin sulfate synthase 2 - Homo sapiens (Human) - CHPF gene Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 may enhance cell viability and protect cells from oxidative stress. Taurus_UMD|evm.model.AC_000159.1.669 Q08E36 TM198_BOVIN 100.000 0.99446 1.00278 TMEM198 - Transmembrane protein 198 - Bos taurus (Bovine) - TMEM198 gene Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity (By similarity). Taurus_UMD|evm.model.AC_000159.1.670 O75147 OBSL1_HUMAN 90.243 0.9963 0.99789 OBSL1 - Obscurin-like protein 1 - Homo sapiens (Human) - OBSL1 gene Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons. Taurus_UMD|evm.model.AC_000159.1.671 P07994 INHA_BOVIN 100.000 0.99446 1.00278 INHA - Inhibin alpha chain precursor - Bos taurus (Bovine) - INHA gene Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Taurus_UMD|evm.model.AC_000159.1.672 Q8N1F8 S11IP_HUMAN 77.757 0.998119 0.977022 STK11IP - Serine/threonine-protein kinase 11-interacting protein - Homo sapiens (Human) - STK11IP gene May regulate STK11/LKB1 function by controlling its subcellular localization. Taurus_UMD|evm.model.AC_000159.1.673 P48751 B3A3_HUMAN 95.292 0.99837 0.995942 SLC4A3 - Anion exchange protein 3 - Homo sapiens (Human) - SLC4A3 gene Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-). Taurus_UMD|evm.model.AC_000159.1.675 P00355 G3P_PIG 57.377 0.984733 0.393393 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Sus scrofa (Pig) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Taurus_UMD|evm.model.AC_000159.1.676 P62907 RL10A_RAT 52.000 0.990566 0.488479 Rpl10a - 60S ribosomal protein L10a - Rattus norvegicus (Rat) - Rpl10a gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000159.1.678 Q03137 EPHA4_MOUSE 98.841 0.973306 0.98783 Epha4 - Ephrin type-A receptor 4 precursor - Mus musculus (Mouse) - Epha4 gene Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions (PubMed:30639848). Taurus_UMD|evm.model.AC_000159.1.681 P23760 PAX3_HUMAN 98.921 0.94863 0.609603 PAX3 - Paired box protein Pax-3 - Homo sapiens (Human) - PAX3 gene Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087). Taurus_UMD|evm.model.AC_000159.1.682 P24610 PAX3_MOUSE 98.980 0.902326 0.448852 Pax3 - Paired box protein Pax-3 - Mus musculus (Mouse) - Pax3 gene Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (By similarity). Taurus_UMD|evm.model.AC_000159.1.684 M0QZC1 RN225_HUMAN 38.542 0.273256 1.04559 RNF225 - RING finger protein 225 - Homo sapiens (Human) - RNF225 gene Taurus_UMD|evm.model.AC_000159.1.685 Q9MYT8 ATP5I_PIG 55.128 0.973333 1.05634 ATP5ME - ATP synthase subunit e, mitochondrial - Sus scrofa (Pig) - ATP5ME gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Taurus_UMD|evm.model.AC_000159.1.686 Q8IWX5 SGPP2_HUMAN 84.171 0.992462 0.997494 SGPP2 - Sphingosine-1-phosphate phosphatase 2 - Homo sapiens (Human) - SGPP2 gene Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (PubMed:12411432). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (PubMed:17113265). Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity). Taurus_UMD|evm.model.AC_000159.1.687 Q9NSD9 SYFB_HUMAN 93.888 0.99661 1.0017 FARSB - Phenylalanine--tRNA ligase beta subunit - Homo sapiens (Human) - FARSB gene cytoplasm, cytosol, membrane, phenylalanine-tRNA ligase complex, phenylalanine-tRNA ligase activity, phenylalanyl-tRNA aminoacylation, protein heterotetramerization, translation, tRNA aminoacylation for protein translation Taurus_UMD|evm.model.AC_000159.1.688 Q63060 GLPK_RAT 94.061 0.940433 1.05725 Gk - Glycerol kinase - Rattus norvegicus (Rat) - Gk gene Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP. Taurus_UMD|evm.model.AC_000159.1.689 Q70VZ7 MOGT1_BOVIN 100.000 0.994048 1.00299 MOGAT1 - 2-acylglycerol O-acyltransferase 1 - Bos taurus (Bovine) - MOGAT1 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine. Taurus_UMD|evm.model.AC_000159.1.690 Q5E995 RS6_BOVIN 99.197 0.992 1.00402 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Taurus_UMD|evm.model.AC_000159.1.691 O95573 ACSL3_HUMAN 94.306 0.997214 0.997222 ACSL3 - Long-chain-fatty-acid--CoA ligase 3 - Homo sapiens (Human) - ACSL3 gene Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity). Taurus_UMD|evm.model.AC_000159.1.692 Q8WWG9 KCNE4_HUMAN 87.647 0.988166 0.764706 KCNE4 - Potassium voltage-gated channel subfamily E member 4 - Homo sapiens (Human) - KCNE4 gene Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current. Taurus_UMD|evm.model.AC_000159.1.693 P20616 SCG2_BOVIN 100.000 0.996743 1.00163 SCG2 - Secretogranin-2 precursor - Bos taurus (Bovine) - SCG2 gene Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. Taurus_UMD|evm.model.AC_000159.1.694 P35720 C560_BOVIN 98.817 0.988235 1.00592 SDHC - Succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor - Bos taurus (Bovine) - SDHC gene Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Taurus_UMD|evm.model.AC_000159.1.695 Q96PC3 AP1S3_HUMAN 96.528 0.922581 1.00649 AP1S3 - AP-1 complex subunit sigma-3 - Homo sapiens (Human) - AP1S3 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904). Taurus_UMD|evm.model.AC_000159.1.696 Q2KIY3 WDFY1_BOVIN 100.000 0.870536 1.09268 WDFY1 - WD repeat and FYVE domain-containing protein 1 - Bos taurus (Bovine) - WDFY1 gene Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines. Taurus_UMD|evm.model.AC_000159.1.697 Q2KIS2 RM44_BOVIN 100.000 0.993994 1.00301 MRPL44 - 39S ribosomal protein L44, mitochondrial precursor - Bos taurus (Bovine) - MRPL44 gene Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. Taurus_UMD|evm.model.AC_000159.1.698 P07093 GDN_HUMAN 76.131 0.740891 1.24121 SERPINE2 - Glia-derived nexin precursor - Homo sapiens (Human) - SERPINE2 gene Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. Taurus_UMD|evm.model.AC_000159.1.699 A6QLD5 F124B_BOVIN 97.423 0.891705 0.941432 FAM124B - Protein FAM124B - Bos taurus (Bovine) - FAM124B gene nucleoplasm Taurus_UMD|evm.model.AC_000159.1.700 B5DF89 CUL3_RAT 99.870 0.997399 1.0013 Cul3 - Cullin-3 - Rattus norvegicus (Rat) - Cul3 gene Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, MACROH2A1 and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL; these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron; by mediating ubiquitination of WNK4. The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. The BCR(KLHL25) ubiquitin ligase complex is involved in translational homeostasis by mediating ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro) thus involved in regulation of G1/S transition. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and RBX1, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediates ubiquitination and degradation of TCHP, a down-regulator of cilium assembly, thereby inducing ciliogenesis (By similarity). The BCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination of KRT14, controls KRT14 levels during keratinocytes differentiation, and is essential for skin integrity (By similarity). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (By similarity). The BCR(KEAP1) E3 ubiquitin ligase complex acts as a key sensor of oxidative and electrophilic stress by mediating ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (By similarity). As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions mediates 'Lys-48' ubiquitination and proteasomal degradation of TIAM1. By controlling the ubiquitination of that RAC1 guanine exchange factors (GEF), regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000159.1.701 A0A1B0GUA6 CC195_HUMAN 64.904 0.990196 1.01493 CCDC195 - Putative coiled-coil domain-containing protein 195 - Homo sapiens (Human) - CCDC195 gene Taurus_UMD|evm.model.AC_000159.1.702 Q96BY6 DOC10_HUMAN 94.732 0.974545 1.0064 DOCK10 - Dedicator of cytokinesis protein 10 - Homo sapiens (Human) - DOCK10 gene Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. Taurus_UMD|evm.model.AC_000159.1.703 Q9P242 NYAP2_HUMAN 93.488 0.835065 1.17917 NYAP2 - Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 - Homo sapiens (Human) - NYAP2 gene Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. Taurus_UMD|evm.model.AC_000159.1.705 P35568 IRS1_HUMAN 90.434 0.998384 0.996779 IRS1 - Insulin receptor substrate 1 - Homo sapiens (Human) - IRS1 gene May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). Taurus_UMD|evm.model.AC_000159.1.706 P49666 RL21_PIG 72.289 0.987952 1.0375 RPL21 - 60S ribosomal protein L21 - Sus scrofa (Pig) - RPL21 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000159.1.707 Q8TEB9 RHBL4_HUMAN 83.544 0.975232 1.0254 RHBDD1 - Rhomboid-related protein 4 - Homo sapiens (Human) - RHBDD1 gene Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia. Taurus_UMD|evm.model.AC_000159.1.708 Q29442 CO4A4_BOVIN 100.000 0.266885 3.36645 COL4A4 - Collagen alpha-4(IV) chain - Bos taurus (Bovine) - COL4A4 gene Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Taurus_UMD|evm.model.AC_000159.1.709 Q28084 CO4A3_BOVIN 99.151 0.281269 3.54777 COL4A3 - Collagen alpha-3(IV) chain - Bos taurus (Bovine) - COL4A3 gene Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Taurus_UMD|evm.model.AC_000159.1.710 Q3ZCD8 MFF_BOVIN 100.000 0.220126 1.45872 MFF - Mitochondrial fission factor - Bos taurus (Bovine) - MFF gene Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. Taurus_UMD|evm.model.AC_000159.1.711 Q3T0Z4 T4S20_BOVIN 99.130 0.991342 1.00435 TM4SF20 - Transmembrane 4 L6 family member 20 - Bos taurus (Bovine) - TM4SF20 gene Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. Taurus_UMD|evm.model.AC_000159.1.713 Q2TA45 AGFG1_BOVIN 100.000 0.808357 1.23488 AGFG1 - Arf-GAP domain and FG repeat-containing protein 1 - Bos taurus (Bovine) - AGFG1 gene Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization (By similarity). Taurus_UMD|evm.model.AC_000159.1.716 Q4R877 S19A3_MACFA 80.285 0.993827 0.979839 SLC19A3 - Thiamine transporter 2 - Macaca fascicularis (Crab-eating macaque) - SLC19A3 gene Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity (By similarity). Taurus_UMD|evm.model.AC_000159.1.717 Q3ZBZ8 STIP1_BOVIN 98.343 0.996324 1.00184 STIP1 - Stress-induced-phosphoprotein 1 - Bos taurus (Bovine) - STIP1 gene Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. Taurus_UMD|evm.model.AC_000159.1.721 Q8SQB1 CCL20_BOVIN 98.969 0.979592 1.02083 CCL20 - C-C motif chemokine 20 precursor - Bos taurus (Bovine) - CCL20 gene Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. Taurus_UMD|evm.model.AC_000159.1.722 Q0P593 DAW1_BOVIN 90.864 0.847575 1.04337 DAW1 - Dynein assembly factor with WDR repeat domains 1 - Bos taurus (Bovine) - DAW1 gene May play a role in axonemal outer row dynein assembly. Taurus_UMD|evm.model.AC_000159.1.723 Q2M3C7 SPKAP_HUMAN 75.409 0.998829 1.00471 SPHKAP - A-kinase anchor protein SPHKAP - Homo sapiens (Human) - SPHKAP gene Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1. Taurus_UMD|evm.model.AC_000159.1.724 Q96SU4 OSBL9_HUMAN 67.347 0.807692 0.141304 OSBPL9 - Oxysterol-binding protein-related protein 9 - Homo sapiens (Human) - OSBPL9 gene cytosol, Golgi apparatus, intracellular membrane-bounded organelle, membrane, sterol binding, sterol transporter activity, bile acid biosynthetic process Taurus_UMD|evm.model.AC_000159.1.725 Q5R9W4 OSBL9_PONAB 84.444 0.917808 0.19837 OSBPL9 - Oxysterol-binding protein-related protein 9 - Pongo abelii (Sumatran orangutan) - OSBPL9 gene Taurus_UMD|evm.model.AC_000159.1.726 Q8IYB1 M21D2_HUMAN 70.565 0.742268 0.592668 MB21D2 - Protein MB21D2 - Homo sapiens (Human) - MB21D2 gene cadherin binding, protein-containing complex binding Taurus_UMD|evm.model.AC_000159.1.727 Q4KLH6 CE162_RAT 80.682 0.913043 0.0655738 Cep162 - Centrosomal protein of 162 kDa - Rattus norvegicus (Rat) - Cep162 gene Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules (By similarity). Taurus_UMD|evm.model.AC_000159.1.728 Q7Z2X4 PCLI1_HUMAN 97.537 0.990196 0.816 PID1 - PTB-containing, cubilin and LRP1-interacting protein - Homo sapiens (Human) - PID1 gene Increases proliferation of preadipocytes without affecting adipocytic differentiation. Taurus_UMD|evm.model.AC_000159.1.729 Q8NFT8 DNER_HUMAN 88.331 0.997253 0.987788 DNER - Delta and Notch-like epidermal growth factor-related receptor precursor - Homo sapiens (Human) - DNER gene Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity). Taurus_UMD|evm.model.AC_000159.1.731 E1B7Q7 TRIPC_BOVIN 96.372 0.999033 1.03815 TRIP12 - E3 ubiquitin-protein ligase TRIP12 - Bos taurus (Bovine) - TRIP12 gene E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex. Taurus_UMD|evm.model.AC_000159.1.732 Q5R796 FBX36_PONAB 80.508 0.975 0.638298 FBXO36 - F-box only protein 36 - Pongo abelii (Sumatran orangutan) - FBXO36 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000159.1.733 Q7RTX9 MOT14_HUMAN 88.672 0.996101 1.00588 SLC16A14 - Monocarboxylate transporter 14 - Homo sapiens (Human) - SLC16A14 gene Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. Taurus_UMD|evm.model.AC_000159.1.734 Q9H930 SP14L_HUMAN 64.764 0.525692 1.30862 SP140L - Nuclear body protein SP140-like protein - Homo sapiens (Human) - SP140L gene nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000159.1.735 Q9H930 SP14L_HUMAN 52.083 0.231144 0.708621 SP140L - Nuclear body protein SP140-like protein - Homo sapiens (Human) - SP140L gene nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000159.1.736 Q9H930 SP14L_HUMAN 68.571 0.319149 0.72931 SP140L - Nuclear body protein SP140-like protein - Homo sapiens (Human) - SP140L gene nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000159.1.737 Q9H930 SP14L_HUMAN 63.429 0.211048 1.21724 SP140L - Nuclear body protein SP140-like protein - Homo sapiens (Human) - SP140L gene nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000159.1.738 Q9Y376 CAB39_HUMAN 100.000 0.934066 1.06745 CAB39 - Calcium-binding protein 39 - Homo sapiens (Human) - CAB39 gene Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. Taurus_UMD|evm.model.AC_000159.1.739 A2VDN0 ITM2C_BOVIN 100.000 0.992647 1.00369 ITM2C - Integral membrane protein 2C - Bos taurus (Bovine) - ITM2C gene Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). Taurus_UMD|evm.model.AC_000159.1.740 Q9Y2T6 GPR55_HUMAN 79.439 0.916905 1.09404 GPR55 - G-protein coupled receptor 55 - Homo sapiens (Human) - GPR55 gene May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function. Taurus_UMD|evm.model.AC_000159.1.742 Q9D9T6 SPTA3_MOUSE 74.227 0.413043 1.19171 Spata3 - Spermatogenesis-associated protein 3 - Mus musculus (Mouse) - Spata3 gene Taurus_UMD|evm.model.AC_000159.1.743 A6NCS6 CB072_HUMAN 75.593 0.765499 1.25763 C2orf72 - Uncharacterized protein C2orf72 - Homo sapiens (Human) - C2orf72 gene Taurus_UMD|evm.model.AC_000159.1.744 Q5R5S4 PSMD1_PONAB 91.291 0.997768 0.940189 PSMD1 - 26S proteasome non-ATPase regulatory subunit 1 - Pongo abelii (Sumatran orangutan) - PSMD1 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Taurus_UMD|evm.model.AC_000159.1.745 Q2KI89 ARMC9_BOVIN 100.000 0.810745 1.23158 ARMC9 - LisH domain-containing protein ARMC9 - Bos taurus (Bovine) - ARMC9 gene Acts as a positive regulator of hedgehog (Hh) signaling (By similarity). Involved in ciliogenesis (By similarity). May participate in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip (By similarity). Taurus_UMD|evm.model.AC_000159.1.746 Q8NFL0 B3GN7_HUMAN 84.289 0.995025 1.00249 B3GNT7 - UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 - Homo sapiens (Human) - B3GNT7 gene May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues. Taurus_UMD|evm.model.AC_000159.1.747 Q99873 ANM1_HUMAN 47.980 0.988095 0.45283 PRMT1 - Protein arginine N-methyltransferase 1 - Homo sapiens (Human) - PRMT1 gene Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:10749851, PubMed:16879614, PubMed:26876602). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Taurus_UMD|evm.model.AC_000159.1.748 Q5RF26 NUCL_PONAB 92.152 0.617198 1.01264 NCL - Nucleolin - Pongo abelii (Sumatran orangutan) - NCL gene Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity). Taurus_UMD|evm.model.AC_000159.1.749 Q9HB89 NMUR1_HUMAN 76.761 0.905172 1.0892 NMUR1 - Neuromedin-U receptor 1 - Homo sapiens (Human) - NMUR1 gene Receptor for the neuromedin-U and neuromedin-S neuropeptides. Taurus_UMD|evm.model.AC_000159.1.750 Q53QW1 TEX44_HUMAN 48.257 0.940341 0.891139 TEX44 - Testis-expressed protein 44 - Homo sapiens (Human) - TEX44 gene cytoplasm Taurus_UMD|evm.model.AC_000159.1.753 P01252 PTMA_BOVIN 100.000 0.598901 1.65455 PTMA - Prothymosin alpha - Bos taurus (Bovine) - PTMA gene Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Taurus_UMD|evm.model.AC_000159.1.754 Q9XT54 PDE6D_CANLF 100.000 0.984848 0.88 PDE6D - Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta - Canis lupus familiaris (Dog) - PDE6D gene Promotes the release of prenylated target proteins from cellular membranes (By similarity). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity). Taurus_UMD|evm.model.AC_000159.1.755 Q3SZ62 PGAM1_BOVIN 84.513 0.929577 0.838583 PGAM1 - Phosphoglycerate mutase 1 - Bos taurus (Bovine) - PGAM1 gene Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. Taurus_UMD|evm.model.AC_000159.1.756 Q2KI56 CSN7B_BOVIN 100.000 0.992453 1.00379 COPS7B - COP9 signalosome complex subunit 7b - Bos taurus (Bovine) - COPS7B gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Taurus_UMD|evm.model.AC_000159.1.757 Q8TD26 CHD6_HUMAN 40.000 0.581006 0.06593 CHD6 - Chromodomain-helicase-DNA-binding protein 6 - Homo sapiens (Human) - CHD6 gene DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. Taurus_UMD|evm.model.AC_000159.1.758 P55206 ANFC_BOVIN 100.000 0.984252 1.00794 NPPC - C-type natriuretic peptide precursor - Bos taurus (Bovine) - NPPC gene Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic. Acts by specifically binding and stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3 (By similarity). Taurus_UMD|evm.model.AC_000159.1.759 Q8IYB7 DI3L2_HUMAN 91.579 0.997895 0.536723 DIS3L2 - DIS3-like exonuclease 2 - Homo sapiens (Human) - DIS3L2 gene 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. Taurus_UMD|evm.model.AC_000159.1.760 P19111 PPBI_BOVIN 67.505 0.954751 0.829268 ALPI - Intestinal-type alkaline phosphatase precursor - Bos taurus (Bovine) - ALPI gene plasma membrane, alkaline phosphatase activity, magnesium ion binding, zinc ion binding, dephosphorylation Taurus_UMD|evm.model.AC_000159.1.761 P19111 PPBI_BOVIN 80.524 0.996241 0.998124 ALPI - Intestinal-type alkaline phosphatase precursor - Bos taurus (Bovine) - ALPI gene plasma membrane, alkaline phosphatase activity, magnesium ion binding, zinc ion binding, dephosphorylation Taurus_UMD|evm.model.AC_000159.1.762 P09923 PPBI_HUMAN 64.990 0.954167 0.909091 ALPI - Intestinal-type alkaline phosphatase precursor - Homo sapiens (Human) - ALPI gene extracellular region, plasma membrane, alkaline phosphatase activity, magnesium ion binding, protease binding, zinc ion binding, dephosphorylation, digestion, phosphatidic acid biosynthetic process Taurus_UMD|evm.model.AC_000159.1.763 P19111 PPBI_BOVIN 81.165 0.960302 0.992495 ALPI - Intestinal-type alkaline phosphatase precursor - Bos taurus (Bovine) - ALPI gene plasma membrane, alkaline phosphatase activity, magnesium ion binding, zinc ion binding, dephosphorylation Taurus_UMD|evm.model.AC_000159.1.764 P19111 PPBI_BOVIN 94.747 0.996255 1.00188 ALPI - Intestinal-type alkaline phosphatase precursor - Bos taurus (Bovine) - ALPI gene plasma membrane, alkaline phosphatase activity, magnesium ion binding, zinc ion binding, dephosphorylation Taurus_UMD|evm.model.AC_000159.1.765 P19111 PPBI_BOVIN 99.062 0.996255 1.00188 ALPI - Intestinal-type alkaline phosphatase precursor - Bos taurus (Bovine) - ALPI gene plasma membrane, alkaline phosphatase activity, magnesium ion binding, zinc ion binding, dephosphorylation Taurus_UMD|evm.model.AC_000159.1.766 O95672 ECEL1_HUMAN 95.871 0.997423 1.00129 ECEL1 - Endothelin-converting enzyme-like 1 - Homo sapiens (Human) - ECEL1 gene May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides. Taurus_UMD|evm.model.AC_000159.1.769 P04759 ACHD_BOVIN 100.000 0.475531 2.09884 CHRND - Acetylcholine receptor subunit delta precursor - Bos taurus (Bovine) - CHRND gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Taurus_UMD|evm.model.AC_000159.1.770 P13536 ACHG_BOVIN 100.000 0.996154 1.00193 CHRNG - Acetylcholine receptor subunit gamma precursor - Bos taurus (Bovine) - CHRNG gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Taurus_UMD|evm.model.AC_000159.1.771 O60573 IF4E2_HUMAN 99.550 0.932489 0.967347 EIF4E2 - Eukaryotic translation initiation factor 4E type 2 - Homo sapiens (Human) - EIF4E2 gene Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:17368478, PubMed:25624349, PubMed:9582349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity). In P-bodies, component of a complex that promotes miRNA-mediated translational repression (PubMed:28487484). Taurus_UMD|evm.model.AC_000159.1.772 O60928 KCJ13_HUMAN 61.184 0.991489 0.652778 KCNJ13 - Inward rectifier potassium channel 13 - Homo sapiens (Human) - KCNJ13 gene Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. Taurus_UMD|evm.model.AC_000159.1.773 B2RTY4 MYO9A_HUMAN 99.301 0.658199 0.169937 MYO9A - Unconventional myosin-IXa - Homo sapiens (Human) - MYO9A gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). Taurus_UMD|evm.model.AC_000159.1.774 Q8IXK0 PHC2_HUMAN 90.717 0.709137 1.39044 PHC2 - Polyhomeotic-like protein 2 - Homo sapiens (Human) - PHC2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Taurus_UMD|evm.model.AC_000159.1.775 Q5T0B9 ZN362_HUMAN 97.789 0.99505 0.961905 ZNF362 - Zinc finger protein 362 - Homo sapiens (Human) - ZNF362 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000159.1.776 Q03279 PO21_BRACO 27.742 0.754902 0.234753 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 - Bradysia coprophila (Dark-winged fungus gnat) Taurus_UMD|evm.model.AC_000159.1.777 Q80V85 TRI62_MOUSE 99.579 0.995798 1.00211 Trim62 - E3 ubiquitin-protein ligase TRIM62 - Mus musculus (Mouse) - Trim62 gene E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (By similarity). Taurus_UMD|evm.model.AC_000159.1.779 Q96A70 AZIN2_HUMAN 73.019 0.995614 0.991304 AZIN2 - Antizyme inhibitor 2 - Homo sapiens (Human) - AZIN2 gene Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728). Taurus_UMD|evm.model.AC_000159.1.780 P08166 KAD2_BOVIN 100.000 0.987234 0.975104 AK2 - Adenylate kinase 2, mitochondrial - Bos taurus (Bovine) - AK2 gene Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. Taurus_UMD|evm.model.AC_000159.1.781 A2A7Q9 RN19B_MOUSE 95.786 0.871287 0.965847 Rnf19b - E3 ubiquitin-protein ligase RNF19B - Mus musculus (Mouse) - Rnf19b gene E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death (By similarity). Taurus_UMD|evm.model.AC_000159.1.782 Q3ZCD2 TMM54_BOVIN 100.000 0.991031 1.0045 TMEM54 - Transmembrane protein 54 - Bos taurus (Bovine) - TMEM54 gene Taurus_UMD|evm.model.AC_000159.1.783 P84076 HPCA_RAT 100.000 0.989691 1.00518 Hpca - Neuron-specific calcium-binding protein hippocalcin - Rattus norvegicus (Rat) - Hpca gene Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (By similarity). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (PubMed:15336960). Taurus_UMD|evm.model.AC_000159.1.784 Q8NAU1 FNDC5_HUMAN 99.448 0.841121 1.00943 FNDC5 - Fibronectin type III domain-containing protein 5 precursor - Homo sapiens (Human) - FNDC5 gene Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue. Taurus_UMD|evm.model.AC_000159.1.785 Q3MHH3 S1PBP_BOVIN 100.000 0.967816 1.03081 S100PBP - S100P-binding protein - Bos taurus (Bovine) - S100PBP gene cytosol, nucleus, calcium-dependent protein binding Taurus_UMD|evm.model.AC_000159.1.786 Q29465 SYYC_BOVIN 99.242 0.996219 1.00189 YARS1 - Tyrosine--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - YARS1 gene Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Taurus_UMD|evm.model.AC_000159.1.787 Q9P206 K1522_HUMAN 83.874 0.928571 1.04155 KIAA1522 - Uncharacterized protein KIAA1522 - Homo sapiens (Human) - KIAA1522 gene cell differentiation Taurus_UMD|evm.model.AC_000159.1.788 Q9H7C4 SYNCI_HUMAN 80.124 0.995833 0.995851 SYNC - Syncoilin - Homo sapiens (Human) - SYNC gene Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins. Taurus_UMD|evm.model.AC_000159.1.789 Q60972 RBBP4_MOUSE 100.000 0.995305 1.00235 Rbbp4 - Histone-binding protein RBBP4 - Mus musculus (Mouse) - Rbbp4 gene Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Taurus_UMD|evm.model.AC_000159.1.790 Q2YDE7 ARCH_BOVIN 100.000 0.988095 1.00599 ZBTB8OS - Protein archease - Bos taurus (Bovine) - ZBTB8OS gene Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (By similarity). Taurus_UMD|evm.model.AC_000159.1.791 Q0VCJ6 ZBT8A_BOVIN 99.773 0.995475 1.00227 ZBTB8A - Zinc finger and BTB domain-containing protein 8A - Bos taurus (Bovine) - ZBTB8A gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000159.1.792 Q8NAP8 ZBT8B_HUMAN 90.058 0.918919 0.373737 ZBTB8B - Zinc finger and BTB domain-containing protein 8B - Homo sapiens (Human) - ZBTB8B gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000159.1.793 Q8NAP8 ZBT8B_HUMAN 79.240 0.861183 0.785859 ZBTB8B - Zinc finger and BTB domain-containing protein 8B - Homo sapiens (Human) - ZBTB8B gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000159.1.794 Q3SX22 BSDC1_BOVIN 100.000 0.986079 0.934924 BSDC1 - BSD domain-containing protein 1 - Bos taurus (Bovine) - BSDC1 gene Taurus_UMD|evm.model.AC_000159.1.795 Q9D2E1 TSSK3_MOUSE 98.134 0.988889 1.00746 Tssk3 - Testis-specific serine/threonine-protein kinase 3 - Mus musculus (Mouse) - Tssk3 gene May be involved in a signaling pathway during male germ cell development or mature sperm function. Taurus_UMD|evm.model.AC_000159.1.796 B2KGE5 F229A_MOUSE 89.844 0.783951 1.26562 Fam229a - Protein FAM229A - Mus musculus (Mouse) - Fam229a gene Taurus_UMD|evm.model.AC_000159.1.797 Q0VBZ9 MRP_BOVIN 100.000 0.853535 1 MARCKSL1 - MARCKS-related protein - Bos taurus (Bovine) - MARCKSL1 gene Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. Taurus_UMD|evm.model.AC_000159.1.798 Q32PJ8 HDAC1_BOVIN 100.000 0.995859 1.00207 HDAC1 - Histone deacetylase 1 - Bos taurus (Bovine) - HDAC1 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. Taurus_UMD|evm.model.AC_000159.1.799 P06239 LCK_HUMAN 96.267 0.996078 1.00196 LCK - Tyrosine-protein kinase Lck - Homo sapiens (Human) - LCK gene Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). Taurus_UMD|evm.model.AC_000159.1.800 Q9BTA0 F167B_HUMAN 88.957 0.98773 1 FAM167B - Protein FAM167B - Homo sapiens (Human) - FAM167B gene Taurus_UMD|evm.model.AC_000159.1.801 Q2KJ24 MTM9L_BOVIN 100.000 0.996324 1.00184 MTMR9L - Myotubularin-related protein 9-like - Bos taurus (Bovine) - MTMR9L gene Probable pseudophosphatase. Taurus_UMD|evm.model.AC_000159.1.802 Q5E966 EIF3I_BOVIN 100.000 0.993865 1.00308 EIF3I - Eukaryotic translation initiation factor 3 subunit I - Bos taurus (Bovine) - EIF3I gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Taurus_UMD|evm.model.AC_000159.1.803 A7YW81 TM234_BOVIN 100.000 0.985816 1.00714 TMEM234 - Transmembrane protein 234 - Bos taurus (Bovine) - TMEM234 gene Taurus_UMD|evm.model.AC_000159.1.804 A2VCK2 DCD2B_HUMAN 81.437 0.97076 0.979943 DCDC2B - Doublecortin domain-containing protein 2B - Homo sapiens (Human) - DCDC2B gene microtubule, microtubule organizing center Taurus_UMD|evm.model.AC_000159.1.805 Q2TBI7 IQCC_BOVIN 99.573 0.995736 1.00214 IQCC - IQ domain-containing protein C - Bos taurus (Bovine) - IQCC gene Taurus_UMD|evm.model.AC_000159.1.806 Q8CEG5 CC28B_MOUSE 95.000 0.805668 1.235 Ccdc28b - Coiled-coil domain-containing protein 28B - Mus musculus (Mouse) - Ccdc28b gene Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex. Taurus_UMD|evm.model.AC_000159.1.807 P62907 RL10A_RAT 97.696 0.990826 1.00461 Rpl10a - 60S ribosomal protein L10a - Rattus norvegicus (Rat) - Rpl10a gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000159.1.808 Q17QW2 TM39B_BOVIN 100.000 0.995943 1.00203 TMEM39B - Transmembrane protein 39B - Bos taurus (Bovine) - TMEM39B gene membrane Taurus_UMD|evm.model.AC_000159.1.809 Q07666 KHDR1_HUMAN 99.538 0.995392 0.979684 KHDRBS1 - KH domain-containing, RNA-binding, signal transduction-associated protein 1 - Homo sapiens (Human) - KHDRBS1 gene Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). Taurus_UMD|evm.model.AC_000159.1.810 Q6AXS9 RFLB_RAT 63.953 0.497076 0.791667 Rflnb - Refilin-B - Rattus norvegicus (Rat) - Rflnb gene Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements. Taurus_UMD|evm.model.AC_000159.1.811 Q3ZCJ7 TBA1C_BOVIN 99.332 0.995556 1.00223 TUBA1C - Tubulin alpha-1C chain - Bos taurus (Bovine) - TUBA1C gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Taurus_UMD|evm.model.AC_000159.1.812 Q6P9X4 TP4A2_RAT 100.000 0.988095 1.00599 Ptp4a2 - Protein tyrosine phosphatase type IVA 2 precursor - Rattus norvegicus (Rat) - Ptp4a2 gene Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity). Taurus_UMD|evm.model.AC_000159.1.813 Q6ZMY3 SPOC1_HUMAN 54.713 0.806424 0.972862 SPOCD1 - SPOC domain-containing protein 1 - Homo sapiens (Human) - SPOCD1 gene Essential excecutor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (By similarity). Associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes (By similarity). Tethering of PIWIL4 to a nascent transposable element transcript recruits repressive chromatin remodeling activities and the de novo methylation apparatus through SPOCD1 (By similarity). Not required for piRNA biosynthesis (By similarity). Taurus_UMD|evm.model.AC_000159.1.814 Q5R7Y0 AGRB2_PONAB 95.886 0.772937 1.0202 ADGRB2 - Adhesion G protein-coupled receptor B2 precursor - Pongo abelii (Sumatran orangutan) - ADGRB2 gene Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition (By similarity). Taurus_UMD|evm.model.AC_000159.1.815 Q8BLX7 COGA1_MOUSE 86.460 0.998759 1.01962 Col16a1 - Collagen alpha-1(XVI) chain precursor - Mus musculus (Mouse) - Col16a1 gene Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology. Taurus_UMD|evm.model.AC_000159.1.816 Q641Z8 PEF1_RAT 87.879 0.684028 1.01767 Pef1 - Peflin - Rattus norvegicus (Rat) - Pef1 gene Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats. In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification. Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium. Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (By similarity). Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (PubMed:27276012). Taurus_UMD|evm.model.AC_000159.1.817 Q0GBZ5 OX1R_BOVIN 100.000 0.995305 1.00235 HCRTR1 - Orexin receptor type 1 - Bos taurus (Bovine) - HCRTR1 gene Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. Taurus_UMD|evm.model.AC_000159.1.818 Q9GZM7 TINAL_HUMAN 90.828 0.948936 1.00642 TINAGL1 - Tubulointerstitial nephritis antigen-like precursor - Homo sapiens (Human) - TINAGL1 gene May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity). Taurus_UMD|evm.model.AC_000159.1.819 P10790 FABPH_BOVIN 100.000 0.985075 1.00752 FABP3 - Fatty acid-binding protein, heart - Bos taurus (Bovine) - FABP3 gene FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Taurus_UMD|evm.model.AC_000159.1.820 Q9NP64 NO40_HUMAN 99.170 0.991736 1.00415 ZCCHC17 - Nucleolar protein of 40 kDa - Homo sapiens (Human) - ZCCHC17 gene identical protein binding, RNA binding, RNA stabilization Taurus_UMD|evm.model.AC_000159.1.821 Q2HJH6 SNR40_BOVIN 99.721 0.994429 1.00279 SNRNP40 - U5 small nuclear ribonucleoprotein 40 kDa protein - Bos taurus (Bovine) - SNRNP40 gene Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. Taurus_UMD|evm.model.AC_000159.1.822 Q4KMZ8 NKAI1_HUMAN 100.000 0.990385 1.00483 NKAIN1 - Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 precursor - Homo sapiens (Human) - NKAIN1 gene regulation of sodium ion transport Taurus_UMD|evm.model.AC_000159.1.824 Q14671 PUM1_HUMAN 99.495 0.998316 1.00169 PUM1 - Pumilio homolog 1 - Homo sapiens (Human) - PUM1 gene Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:21572425, PubMed:18328718, PubMed:21653694, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). Taurus_UMD|evm.model.AC_000159.1.825 O75056 SDC3_HUMAN 92.405 0.877506 1.01584 SDC3 - Syndecan-3 - Homo sapiens (Human) - SDC3 gene Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Taurus_UMD|evm.model.AC_000159.1.827 Q2KJA5 LAPM5_BOVIN 100.000 0.992453 1.00379 LAPTM5 - Lysosomal-associated transmembrane protein 5 - Bos taurus (Bovine) - LAPTM5 gene May have a special functional role during embryogenesis and in adult hematopoietic cells. Taurus_UMD|evm.model.AC_000159.1.828 P21941 MATN1_HUMAN 90.835 0.947776 1.04234 MATN1 - Cartilage matrix protein precursor - Homo sapiens (Human) - MATN1 gene Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen. Taurus_UMD|evm.model.AC_000159.1.832 Q92729 PTPRU_HUMAN 87.500 0.533898 0.0816044 PTPRU - Receptor-type tyrosine-protein phosphatase U precursor - Homo sapiens (Human) - PTPRU gene Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. Taurus_UMD|evm.model.AC_000159.1.834 Q92729 PTPRU_HUMAN 96.542 0.998608 0.993776 PTPRU - Receptor-type tyrosine-protein phosphatase U precursor - Homo sapiens (Human) - PTPRU gene Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. Taurus_UMD|evm.model.AC_000159.1.835 Q7YS70 MECR_BOVIN 85.263 0.954667 1.00536 MECR - Enoyl-[acyl-carrier-protein] reductase, mitochondrial precursor - Bos taurus (Bovine) - MECR gene Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II) (PubMed:12654921). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (By similarity). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (By similarity). Taurus_UMD|evm.model.AC_000159.1.836 Q8VE97 SRSF4_MOUSE 95.724 0.611336 1.01022 Srsf4 - Serine/arginine-rich splicing factor 4 - Mus musculus (Mouse) - Srsf4 gene Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10 (By similarity). Taurus_UMD|evm.model.AC_000159.1.837 Q69YZ2 T200B_HUMAN 93.485 0.993506 1.00326 TMEM200B - Transmembrane protein 200B - Homo sapiens (Human) - TMEM200B gene Taurus_UMD|evm.model.AC_000159.1.838 Q9N179 EPB41_BOVIN 92.971 0.43557 1.52188 EPB41 - Protein 4.1 - Bos taurus (Bovine) - EPB41 gene Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase. Taurus_UMD|evm.model.AC_000159.1.839 P79291 OPRD_PIG 98.788 0.522293 1.37719 OPRD1 - Delta-type opioid receptor - Sus scrofa (Pig) - OPRD1 gene G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. Taurus_UMD|evm.model.AC_000159.1.840 Q0VCZ3 YTHD2_BOVIN 100.000 0.996558 1.00172 YTHDF2 - YTH domain-containing family protein 2 - Bos taurus (Bovine) - YTHDF2 gene Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. M6A-containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC-3') are preferentially degraded by endoribonucleolytic cleavage: cooperative binding of RIDA/HRSP12 and YTHDF2 to transcripts leads to recruitment of the ribonuclease P/MRP complex. Other m6A-containing mRNAs undergo deadenylation via direct interaction between YTHDF2 and CNOT1, leading to recruitment of the CCR4-NOT and subsequent deadenylation of m6A-containing mRNAs (By similarity). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development. Also required during spermatogenesis: regulates spermagonial adhesion by promoting degradation of m6A-containing transcripts coding for matrix metallopeptidases (By similarity). Also involved in hematopoietic stem cells specification by binding to m6A-containing mRNAs, leading to promote their degradation (By similarity). Also acts as a regulator of neural development by promoting m6A-dependent degradation of neural development-related mRNA targets (By similarity). Inhibits neural specification of induced pluripotent stem cells by binding to methylated neural-specific mRNAs and promoting their degradation, thereby restraining neural differentiation. Regulates circadian regulation of hepatic lipid metabolism: acts by promoting m6A-dependent degradation of PPARA transcripts. Regulates the innate immune response to infection by inhibiting the type I interferon response: acts by binding to m6A-containing IFNB transcripts and promoting their degradation. May also act as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation. Regulates mitotic entry by promoting the phase-specific m6A-dependent degradation of WEE1 transcripts. Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation. The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules. May also recognize and bind RNAs modified by C5-methylcytosine (m5C) and act as a regulator of rRNA processing (By similarity). Taurus_UMD|evm.model.AC_000159.1.841 Q2HJ87 GMEB1_BOVIN 99.822 0.996454 1.00178 GMEB1 - Glucocorticoid modulatory element-binding protein 1 - Bos taurus (Bovine) - GMEB1 gene Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity). Taurus_UMD|evm.model.AC_000159.1.842 Q3T174 TAF12_BOVIN 100.000 0.747664 1.32919 TAF12 - Transcription initiation factor TFIID subunit 12 - Bos taurus (Bovine) - TAF12 gene TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription (By similarity). Taurus_UMD|evm.model.AC_000159.1.843 Q8N4Z0 RAB42_HUMAN 80.000 0.99095 1.01376 RAB42 - Ras-related protein Rab-42 - Homo sapiens (Human) - RAB42 gene plasma membrane, GDP binding, GTP binding, GTPase activity, Ras protein signal transduction Taurus_UMD|evm.model.AC_000159.1.845 Q1RMJ7 TSAP1_BOVIN 100.000 0.993056 1.00348 TRNAU1AP - tRNA selenocysteine 1-associated protein 1 - Bos taurus (Bovine) - TRNAU1AP gene Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity). Taurus_UMD|evm.model.AC_000159.1.846 P18754 RCC1_HUMAN 95.249 0.992908 1.00475 RCC1 - Regulator of chromosome condensation - Homo sapiens (Human) - RCC1 gene Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:1944575, PubMed:17435751, PubMed:20668449, PubMed:22215983, PubMed:11336674). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). Taurus_UMD|evm.model.AC_000159.1.847 F1MCY2 PHAR4_BOVIN 99.714 0.99431 0.98736 PHACTR4 - Phosphatase and actin regulator 4 - Bos taurus (Bovine) - PHACTR4 gene Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). Taurus_UMD|evm.model.AC_000159.1.848 Q2HJI3 F136A_BOVIN 94.203 0.958042 1.03623 FAM136A - Protein FAM136A - Bos taurus (Bovine) - FAM136A gene cytoplasm Taurus_UMD|evm.model.AC_000159.1.849 Q02543 RL18A_HUMAN 80.682 0.987179 0.886364 RPL18A - 60S ribosomal protein L18a - Homo sapiens (Human) - RPL18A gene cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, polysomal ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, rRNA processing Taurus_UMD|evm.model.AC_000159.1.850 Q0VCD4 MED18_BOVIN 100.000 0.990431 1.00481 MED18 - Mediator of RNA polymerase II transcription subunit 18 - Bos taurus (Bovine) - MED18 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Taurus_UMD|evm.model.AC_000159.1.852 Q96JM2 ZN462_HUMAN 90.722 0.914286 0.0418994 ZNF462 - Zinc finger protein 462 - Homo sapiens (Human) - ZNF462 gene Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). Taurus_UMD|evm.model.AC_000159.1.853 Q58CN8 SESN2_BOVIN 100.000 0.995763 1.00212 SESN2 - Sestrin-2 - Bos taurus (Bovine) - SESN2 gene Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress. Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed. Taurus_UMD|evm.model.AC_000159.1.854 P01096 ATIF1_BOVIN 100.000 0.981818 1.00917 ATP5IF1 - ATPase inhibitor, mitochondrial precursor - Bos taurus (Bovine) - ATP5IF1 gene Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Taurus_UMD|evm.model.AC_000159.1.855 Q642C0 DNJC8_RAT 99.605 0.992126 1.00395 Dnajc8 - DnaJ homolog subfamily C member 8 - Rattus norvegicus (Rat) - Dnajc8 gene Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells. Taurus_UMD|evm.model.AC_000159.1.856 P61247 RS3A_HUMAN 95.745 0.699248 0.503788 RPS3A - 40S ribosomal protein S3a - Homo sapiens (Human) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Taurus_UMD|evm.model.AC_000159.1.857 P61247 RS3A_HUMAN 98.701 0.987097 0.587121 RPS3A - 40S ribosomal protein S3a - Homo sapiens (Human) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Taurus_UMD|evm.model.AC_000159.1.858 Q9TTY5 PTAFR_BOVIN 100.000 0.966006 1.03216 PTAFR - Platelet-activating factor receptor - Bos taurus (Bovine) - PTAFR gene Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. May be involved in the morphological and physical modifications of the oviduct and uterus during the estrus cycle and early pregnancy (By similarity). Taurus_UMD|evm.model.AC_000159.1.859 A5A6H4 ROA1_PANTR 88.235 0.923077 0.284375 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Pan troglodytes (Chimpanzee) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. Taurus_UMD|evm.model.AC_000159.1.860 Q32P51 RA1L2_HUMAN 88.679 0.590909 0.275 HNRNPA1L2 - Heterogeneous nuclear ribonucleoprotein A1-like 2 - Homo sapiens (Human) - HNRNPA1L2 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. Taurus_UMD|evm.model.AC_000159.1.861 Q99504 EYA3_HUMAN 96.510 0.877301 1.13787 EYA3 - Eyes absent homolog 3 - Homo sapiens (Human) - EYA3 gene Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. Taurus_UMD|evm.model.AC_000159.1.863 Q49LS0 XKR8_PANTR 78.228 0.956098 1.03797 XKR8 - XK-related protein 8 - Pan troglodytes (Chimpanzee) - XKR8 gene Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis (By similarity). Taurus_UMD|evm.model.AC_000159.1.864 Q92485 ASM3B_HUMAN 81.321 0.958425 1.0044 SMPDL3B - Acid sphingomyelinase-like phosphodiesterase 3b precursor - Homo sapiens (Human) - SMPDL3B gene Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity). Taurus_UMD|evm.model.AC_000159.1.865 P15927 RFA2_HUMAN 93.333 0.739011 1.34815 RPA2 - Replication protein A 32 kDa subunit - Homo sapiens (Human) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Taurus_UMD|evm.model.AC_000159.1.866 Q5TEJ8 THMS2_HUMAN 71.273 0.99689 1 THEMIS2 - Protein THEMIS2 - Homo sapiens (Human) - THEMIS2 gene May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716). Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity). Taurus_UMD|evm.model.AC_000159.1.867 Q791T5 MTCH1_MOUSE 70.000 0.183962 0.544987 Mtch1 - Mitochondrial carrier homolog 1 - Mus musculus (Mouse) - Mtch1 gene Potential mitochondrial transporter. May play a role in apoptosis (By similarity). Taurus_UMD|evm.model.AC_000159.1.868 Q12972 PP1R8_HUMAN 100.000 0.994318 1.00285 PPP1R8 - Nuclear inhibitor of protein phosphatase 1 - Homo sapiens (Human) - PPP1R8 gene Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Taurus_UMD|evm.model.AC_000159.1.869 Q86Y82 STX12_HUMAN 96.887 0.930909 0.996377 STX12 - Syntaxin-12 - Homo sapiens (Human) - STX12 gene SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). Taurus_UMD|evm.model.AC_000159.1.870 Q5EA89 FA76A_BOVIN 99.674 0.993506 1.00326 FAM76A - Protein FAM76A - Bos taurus (Bovine) - FAM76A gene nucleoplasm Taurus_UMD|evm.model.AC_000159.1.871 Q6IED8 IFI6_BOVIN 100.000 0.985185 1.00746 IFI6 - Interferon alpha-inducible protein 6 - Bos taurus (Bovine) - IFI6 gene Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (By similarity). However, it has also been shown to have a pro-apoptotic activity (By similarity). May have an antiviral activity (By similarity). Taurus_UMD|evm.model.AC_000159.1.873 P09769 FGR_HUMAN 89.981 0.996212 0.99811 FGR - Tyrosine-protein kinase Fgr - Homo sapiens (Human) - FGR gene Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). Taurus_UMD|evm.model.AC_000159.1.874 Q5TGY3 AHDC1_HUMAN 96.509 0.998748 0.996881 AHDC1 - AT-hook DNA-binding motif-containing protein 1 - Homo sapiens (Human) - AHDC1 gene Taurus_UMD|evm.model.AC_000159.1.875 A2VDK6 WASF2_BOVIN 100.000 0.995951 1.00203 WASF2 - Wiskott-Aldrich syndrome protein family member 2 - Bos taurus (Bovine) - WASF2 gene Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). Taurus_UMD|evm.model.AC_000159.1.876 P46089 GPR3_HUMAN 95.455 0.993958 1.00303 GPR3 - G-protein coupled receptor 3 - Homo sapiens (Human) - GPR3 gene Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity). Taurus_UMD|evm.model.AC_000159.1.877 Q6UWJ8 C16L2_HUMAN 79.882 0.837563 1.13218 CD164L2 - CD164 sialomucin-like 2 protein precursor - Homo sapiens (Human) - CD164L2 gene cytoplasmic vesicle Taurus_UMD|evm.model.AC_000159.1.878 O95382 M3K6_HUMAN 87.664 0.995385 1.00932 MAP3K6 - Mitogen-activated protein kinase kinase kinase 6 - Homo sapiens (Human) - MAP3K6 gene Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. Taurus_UMD|evm.model.AC_000159.1.879 Q8IYJ3 SYTL1_HUMAN 79.522 0.996593 1.04448 SYTL1 - Synaptotagmin-like protein 1 - Homo sapiens (Human) - SYTL1 gene May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity). Taurus_UMD|evm.model.AC_000159.1.880 Q9H0R3 TM222_HUMAN 69.020 0.992032 1.20673 TMEM222 - Transmembrane protein 222 - Homo sapiens (Human) - TMEM222 gene Taurus_UMD|evm.model.AC_000159.1.881 Q8N5D0 WDTC1_HUMAN 100.000 0.474074 0.199409 WDTC1 - WD and tetratricopeptide repeats protein 1 - Homo sapiens (Human) - WDTC1 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Taurus_UMD|evm.model.AC_000159.1.882 Q80ZK9 WDTC1_MOUSE 97.122 0.638889 0.319055 Wdtc1 - WD and tetratricopeptide repeats protein 1 - Mus musculus (Mouse) - Wdtc1 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Taurus_UMD|evm.model.AC_000159.1.883 Q8N5D0 WDTC1_HUMAN 99.513 0.995146 0.608567 WDTC1 - WD and tetratricopeptide repeats protein 1 - Homo sapiens (Human) - WDTC1 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Taurus_UMD|evm.model.AC_000159.1.884 Q5JSQ8 KHDCL_HUMAN 43.284 0.507812 1 KHDC1L - Putative KHDC1-like protein - Homo sapiens (Human) - KHDC1L gene cytoplasm, RNA binding, activation of cysteine-type endopeptidase activity involved in apoptotic process Taurus_UMD|evm.model.AC_000159.1.885 Q28036 SL9A1_BOVIN 99.389 0.997558 1.00245 SLC9A1 - Sodium/hydrogen exchanger 1 - Bos taurus (Bovine) - SLC9A1 gene Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Taurus_UMD|evm.model.AC_000159.1.886 Q29RH2 TET5B_BOVIN 100.000 0.99536 1.00233 TENT5B - Terminal nucleotidyltransferase 5B - Bos taurus (Bovine) - TENT5B gene Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase. Taurus_UMD|evm.model.AC_000159.1.887 Q6NT89 TRNP1_HUMAN 92.135 0.752137 0.515419 TRNP1 - TMF-regulated nuclear protein 1 - Homo sapiens (Human) - TRNP1 gene DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points (By similarity). Taurus_UMD|evm.model.AC_000159.1.888 Q8NAX2 KDF1_HUMAN 92.211 0.994987 1.00251 KDF1 - Keratinocyte differentiation factor 1 - Homo sapiens (Human) - KDF1 gene Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). Taurus_UMD|evm.model.AC_000159.1.889 Q17QG2 NUDC_BOVIN 100.000 0.993994 1.00301 NUDC - Nuclear migration protein nudC - Bos taurus (Bovine) - NUDC gene Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity). Necessary for cytokinesis and cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000159.1.890 Q15466 NR0B2_HUMAN 79.923 0.988506 1.01556 NR0B2 - Nuclear receptor subfamily 0 group B member 2 - Homo sapiens (Human) - NR0B2 gene Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity). Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (PubMed:14752053). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity). Taurus_UMD|evm.model.AC_000159.1.891 Q96I76 GPTC3_HUMAN 83.429 0.968105 1.01524 GPATCH3 - G patch domain-containing protein 3 - Homo sapiens (Human) - GPATCH3 gene Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development (PubMed:28397860). Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 (PubMed:28414768). Taurus_UMD|evm.model.AC_000159.1.892 A6H7F2 GPN2_BOVIN 100.000 0.993569 1.00323 GPN2 - GPN-loop GTPase 2 - Bos taurus (Bovine) - GPN2 gene Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. Taurus_UMD|evm.model.AC_000159.1.893 O77642 1433S_SHEEP 100.000 0.991968 1.00403 SFN - 14-3-3 protein sigma - Ovis aries (Sheep) - SFN gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity). Taurus_UMD|evm.model.AC_000159.1.894 Q9NUE0 ZDH18_HUMAN 90.823 0.954545 0.850515 ZDHHC18 - Palmitoyltransferase ZDHHC18 - Homo sapiens (Human) - ZDHHC18 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:23034182, PubMed:27481942). Palmitoylates HRAS and LCK (By similarity). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). Taurus_UMD|evm.model.AC_000159.1.895 Q9NUD9 PIGV_HUMAN 84.178 0.995951 1.00203 PIGV - GPI mannosyltransferase 2 - Homo sapiens (Human) - PIGV gene Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. Taurus_UMD|evm.model.AC_000159.1.896 O14497 ARI1A_HUMAN 95.274 0.975583 0.806565 ARID1A - AT-rich interactive domain-containing protein 1A - Homo sapiens (Human) - ARID1A gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Taurus_UMD|evm.model.AC_000159.1.897 Q15418 KS6A1_HUMAN 99.048 0.997283 1.00136 RPS6KA1 - Ribosomal protein S6 kinase alpha-1 - Homo sapiens (Human) - RPS6KA1 gene Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Taurus_UMD|evm.model.AC_000159.1.898 P80272 HMGN2_PIG 100.000 0.640625 0.711111 HMGN2 - Non-histone chromosomal protein HMG-17 - Sus scrofa (Pig) - HMGN2 gene Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). Taurus_UMD|evm.model.AC_000159.1.899 Q86SQ9 DHDDS_HUMAN 94.910 0.890374 1.12312 DHDDS - Dehydrodolichyl diphosphate synthase complex subunit DHDDS - Homo sapiens (Human) - DHDDS gene With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:25066056, PubMed:28842490, PubMed:32817466). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). Taurus_UMD|evm.model.AC_000159.1.900 Q8K3Y3 LN28A_MOUSE 95.694 0.990291 0.985646 Lin28a - Protein lin-28 homolog A - Mus musculus (Mouse) - Lin28a gene RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:17473174, PubMed:18604195, PubMed:18566191, PubMed:18292307, PubMed:19703396, PubMed:23102813, PubMed:24209617). Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (PubMed:26045559). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (PubMed:17473174). Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits TUT4 and TUT7 uridylyltransferaseS. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:19703396, PubMed:28671666). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins (PubMed:23102813). Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (PubMed:24209617). Taurus_UMD|evm.model.AC_000159.1.901 Q60636 PRDM1_MOUSE 70.946 0.280392 0.595794 Prdm1 - PR domain zinc finger protein 1 - Mus musculus (Mouse) - Prdm1 gene Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:27102484). Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:27102484). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (By similarity). Drives the maturation of B-lymphocytes into Ig secreting cells (By similarity). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (PubMed:27102484). Taurus_UMD|evm.model.AC_000159.1.902 Q8N1P7 CRBG2_HUMAN 76.431 0.628844 1.13546 CRYBG2 - Beta/gamma crystallin domain-containing protein 2 - Homo sapiens (Human) - CRYBG2 gene Taurus_UMD|evm.model.AC_000159.1.903 Q28896 CD52_CANLF 70.149 0.969697 0.985075 CD52 - CAMPATH-1 antigen precursor - Canis lupus familiaris (Dog) - CD52 gene May play a role in carrying and orienting carbohydrate, as well as having a more specific role. Taurus_UMD|evm.model.AC_000159.1.904 Q5T124 UBX11_HUMAN 79.545 0.931034 0.892308 UBXN11 - UBX domain-containing protein 11 - Homo sapiens (Human) - UBXN11 gene May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity). Taurus_UMD|evm.model.AC_000159.1.905 Q9H299 SH3L3_HUMAN 100.000 0.978723 1.01075 SH3BGRL3 - SH3 domain-binding glutamic acid-rich-like protein 3 - Homo sapiens (Human) - SH3BGRL3 gene Could act as a modulator of glutaredoxin biological activity. Taurus_UMD|evm.model.AC_000159.1.906 Q6P2H3 CEP85_HUMAN 88.036 0.436893 2.2979 CEP85 - Centrosomal protein of 85 kDa - Homo sapiens (Human) - CEP85 gene Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). Taurus_UMD|evm.model.AC_000159.1.907 Q969H4 CNKR1_HUMAN 84.768 0.721154 0.288889 CNKSR1 - Connector enhancer of kinase suppressor of ras 1 - Homo sapiens (Human) - CNKSR1 gene May function as an adapter protein or regulator of Ras signaling pathways. Taurus_UMD|evm.model.AC_000159.1.908 Q8BVN3 CTSR4_MOUSE 63.158 0.836364 0.248869 Catsper4 - Cation channel sperm-associated protein 4 - Mus musculus (Mouse) - Catsper4 gene Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. Taurus_UMD|evm.model.AC_000159.1.909 Q969H4 CNKR1_HUMAN 75.304 0.995876 0.673611 CNKSR1 - Connector enhancer of kinase suppressor of ras 1 - Homo sapiens (Human) - CNKSR1 gene May function as an adapter protein or regulator of Ras signaling pathways. Taurus_UMD|evm.model.AC_000159.1.910 O00488 ZN593_HUMAN 93.284 0.985185 1.00746 ZNF593 - Zinc finger protein 593 - Homo sapiens (Human) - ZNF593 gene Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins. Taurus_UMD|evm.model.AC_000159.1.911 A0A0U1RR37 CA232_HUMAN 83.333 0.730612 1.3172 C1orf232 - Uncharacterized protein C1orf232 - Homo sapiens (Human) - C1orf232 gene Taurus_UMD|evm.model.AC_000159.1.912 A6H7I7 F110D_BOVIN 100.000 0.99262 1.0037 FAM110D - Protein FAM110D - Bos taurus (Bovine) - FAM110D gene Taurus_UMD|evm.model.AC_000159.1.913 Q8QZR7 PDK1L_MOUSE 99.413 0.994152 1.00293 Pdik1l - Serine/threonine-protein kinase PDIK1L - Mus musculus (Mouse) - Pdik1l gene nucleoplasm, nucleus, protein kinase activity, protein serine/threonine kinase activity, meiotic cell cycle Taurus_UMD|evm.model.AC_000159.1.915 Q969Q1 TRI63_HUMAN 93.272 0.91831 1.00567 TRIM63 - E3 ubiquitin-protein ligase TRIM63 - Homo sapiens (Human) - TRIM63 gene E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. Taurus_UMD|evm.model.AC_000159.1.916 Q62941 ZNT2_RAT 78.492 0.946809 1.04735 Slc30a2 - Zinc transporter 2 - Rattus norvegicus (Rat) - Slc30a2 gene Involved in accumulation of zinc in endosomal/lysosomal vesicles. Taurus_UMD|evm.model.AC_000159.1.917 Q92935 EXTL1_HUMAN 78.171 0.997041 1 EXTL1 - Exostosin-like 1 - Homo sapiens (Human) - EXTL1 gene Probable glycosyltransferase. Taurus_UMD|evm.model.AC_000159.1.918 P79106 PAFA2_BOVIN 100.000 0.92435 1.07908 PAFAH2 - Platelet-activating factor acetylhydrolase 2, cytoplasmic - Bos taurus (Bovine) - PAFAH2 gene Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (PubMed:7673213, PubMed:8955149, PubMed:9405438). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (PubMed:7673213). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity). Taurus_UMD|evm.model.AC_000159.1.919 Q6DUB7 STMN1_PIG 100.000 0.986667 1.00671 STMN1 - Stathmin - Sus scrofa (Pig) - STMN1 gene Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules (By similarity). Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). Taurus_UMD|evm.model.AC_000159.1.921 Q865K8 PAQR7_PIG 96.571 0.994302 1.00286 PAQR7 - Membrane progestin receptor alpha - Sus scrofa (Pig) - PAQR7 gene Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. Involved in neurosteroid inhibition of apoptosis. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone. Taurus_UMD|evm.model.AC_000159.1.922 A4IFU8 AUNIP_BOVIN 100.000 0.994413 1.0028 AUNIP - Aurora kinase A and ninein-interacting protein - Bos taurus (Bovine) - AUNIP gene DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle. Taurus_UMD|evm.model.AC_000159.1.923 Q3ZBW7 MFR1L_BOVIN 100.000 0.993103 1.00346 MTFR1L - Mitochondrial fission regulator 1-like - Bos taurus (Bovine) - MTFR1L gene mitochondrion, aerobic respiration, mitochondrial fission Taurus_UMD|evm.model.AC_000159.1.924 Q9NZV5 SELN_HUMAN 93.750 0.954887 0.225424 SELENON - Selenoprotein N precursor - Homo sapiens (Human) - SELENON gene Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863). Taurus_UMD|evm.model.AC_000159.1.925 D3Z2R5 SELN_MOUSE 91.599 0.857809 0.770197 Selenon - Selenoprotein N precursor - Mus musculus (Mouse) - Selenon gene Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (By similarity). Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290). Taurus_UMD|evm.model.AC_000159.1.926 Q9NR34 MA1C1_HUMAN 89.699 0.996835 1.00317 MAN1C1 - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC - Homo sapiens (Human) - MAN1C1 gene Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc. Taurus_UMD|evm.model.AC_000159.1.927 Q5SW96 ARH_HUMAN 91.613 0.993569 1.00974 LDLRAP1 - Low density lipoprotein receptor adapter protein 1 - Homo sapiens (Human) - LDLRAP1 gene Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity). Taurus_UMD|evm.model.AC_000159.1.928 Q2TLZ3 MACOI_BOVIN 100.000 0.996992 1.00151 MACO1 - Macoilin - Bos taurus (Bovine) - MACO1 gene Plays a role in the regulation of neuronal activity. Taurus_UMD|evm.model.AC_000159.1.929 Q28426 RHLC_GORGO 59.223 0.980907 1.0048 RH-like protein IC - Gorilla gorilla gorilla (Western lowland gorilla) Taurus_UMD|evm.model.AC_000159.1.930 O95807 TM50A_HUMAN 96.178 0.987342 1.00637 TMEM50A - Transmembrane protein 50A - Homo sapiens (Human) - TMEM50A gene endoplasmic reticulum, late endosome to vacuole transport via multivesicular body sorting pathway Taurus_UMD|evm.model.AC_000159.1.931 Q4QRB2 SYF2_RAT 93.220 0.491632 1.97521 Syf2 - Pre-mRNA-splicing factor SYF2 - Rattus norvegicus (Rat) - Syf2 gene Involved in pre-mRNA splicing as component of the spliceosome. Taurus_UMD|evm.model.AC_000159.1.933 Q13761 RUNX3_HUMAN 70.130 0.757576 0.238554 RUNX3 - Runt-related transcription factor 3 - Homo sapiens (Human) - RUNX3 gene Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Taurus_UMD|evm.model.AC_000159.1.934 Q13761 RUNX3_HUMAN 92.901 0.896648 0.862651 RUNX3 - Runt-related transcription factor 3 - Homo sapiens (Human) - RUNX3 gene Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Taurus_UMD|evm.model.AC_000159.1.935 Q9XSA7 CLIC4_BOVIN 86.561 0.991111 0.889328 CLIC4 - Chloride intracellular channel protein 4 - Bos taurus (Bovine) - CLIC4 gene Can insert into membranes and form chloride ion channels. Taurus_UMD|evm.model.AC_000159.1.936 Q5R5Q2 SRRM1_PONAB 97.492 0.997817 0.998909 SRRM1 - Serine/arginine repetitive matrix protein 1 - Pongo abelii (Sumatran orangutan) - SRRM1 gene Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. Taurus_UMD|evm.model.AC_000159.1.937 Q5T1S8 NCMAP_HUMAN 86.275 0.673333 1.47059 NCMAP - Noncompact myelin-associated protein - Homo sapiens (Human) - NCMAP gene Plays a role in myelin formation. Taurus_UMD|evm.model.AC_000159.1.938 Q2KIA1 RCAN3_BOVIN 100.000 0.991736 1.00415 RCAN3 - Calcipressin-3 - Bos taurus (Bovine) - RCAN3 gene Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity). Taurus_UMD|evm.model.AC_000159.1.939 Q5RD30 NPAL3_PONAB 94.089 0.995086 1.00246 NIPAL3 - NIPA-like protein 3 - Pongo abelii (Sumatran orangutan) - NIPAL3 gene Taurus_UMD|evm.model.AC_000159.1.940 A6QQ60 STPG1_BOVIN 100.000 0.994048 1.00299 STPG1 - O(6)-methylguanine-induced apoptosis 2 - Bos taurus (Bovine) - STPG1 gene May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine. Taurus_UMD|evm.model.AC_000159.1.941 Q5FWH3 GRHL3_MOUSE 90.050 0.996683 1 Grhl3 - Grainyhead-like protein 3 homolog - Mus musculus (Mouse) - Grhl3 gene Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. Essential for epidermal differentiation and barrier formation at the end of embryogenesis with TGM3 as critical direct target (PubMed:21081122, PubMed:20654612, PubMed:25347468). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events such as eyelid fusion and epidermal wound repair (PubMed:21081122). Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury (PubMed:25347468). Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (PubMed:14608380, PubMed:20654612). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL1, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122). Taurus_UMD|evm.model.AC_000159.1.944 Q8IU57 INLR1_HUMAN 65.918 0.99619 1.00962 IFNLR1 - Interferon lambda receptor 1 precursor - Homo sapiens (Human) - IFNLR1 gene The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Taurus_UMD|evm.model.AC_000159.1.945 Q3SYS8 I22R1_BOVIN 99.484 0.996564 1.00172 IL22RA1 - Interleukin-22 receptor subunit alpha-1 precursor - Bos taurus (Bovine) - IL22RA1 gene Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation (By similarity). Taurus_UMD|evm.model.AC_000159.1.946 Q5VTT5 MYOM3_HUMAN 84.813 0.997922 1.00487 MYOM3 - Myomesin-3 - Homo sapiens (Human) - MYOM3 gene May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. Taurus_UMD|evm.model.AC_000159.1.947 Q9R0U0 SRS10_MOUSE 92.614 0.892857 0.748092 Srsf10 - Serine/arginine-rich splicing factor 10 - Mus musculus (Mouse) - Srsf10 gene Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (By similarity). May be involved in regulation of alternative splicing in neurons (PubMed:10583508). Taurus_UMD|evm.model.AC_000159.1.948 Q0VCW6 PNRC2_BOVIN 100.000 0.985714 1.00719 PNRC2 - Proline-rich nuclear receptor coactivator 2 - Bos taurus (Bovine) - PNRC2 gene Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure. Taurus_UMD|evm.model.AC_000159.1.949 P34972 CNR2_HUMAN 82.730 0.98895 1.00556 CNR2 - Cannabinoid receptor 2 - Homo sapiens (Human) - CNR2 gene Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Taurus_UMD|evm.model.AC_000159.1.950 Q2KIM0 FUCO_BOVIN 100.000 0.995736 1.00214 FUCA1 - Tissue alpha-L-fucosidase precursor - Bos taurus (Bovine) - FUCA1 gene Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Taurus_UMD|evm.model.AC_000159.1.951 Q29448 HMGCL_BOVIN 100.000 0.993865 1.00308 HMGCL - Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor - Bos taurus (Bovine) - HMGCL gene Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. Taurus_UMD|evm.model.AC_000159.1.953 Q3T105 GALE_BOVIN 100.000 0.994269 1.00287 GALE - UDP-glucose 4-epimerase - Bos taurus (Bovine) - GALE gene Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. Taurus_UMD|evm.model.AC_000159.1.954 O95372 LYPA2_HUMAN 98.496 0.94964 0.601732 LYPLA2 - Acyl-protein thioesterase 2 - Homo sapiens (Human) - LYPLA2 gene Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951). Taurus_UMD|evm.model.AC_000159.1.955 Q9GZP4 PITH1_HUMAN 98.578 0.990566 1.00474 PITHD1 - PITH domain-containing protein 1 - Homo sapiens (Human) - PITHD1 gene Promotes megakaryocyte differentiation by up-regulating RUNX1 expression (PubMed:25134913). Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry site (IRES) element in the RUNX1 gene (PubMed:25134913). Taurus_UMD|evm.model.AC_000159.1.956 Q14241 ELOA1_HUMAN 83.354 0.997509 1.00627 ELOA - Elongin-A - Homo sapiens (Human) - ELOA gene SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). Taurus_UMD|evm.model.AC_000159.1.957 P62914 RL11_RAT 100.000 0.988827 1.00562 Rpl11 - 60S ribosomal protein L11 - Rattus norvegicus (Rat) - Rpl11 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Promotes nucleolar location of PML. Taurus_UMD|evm.model.AC_000159.1.958 Q5E981 ID3_BOVIN 92.727 0.147099 6.22689 ID3 - DNA-binding protein inhibitor ID-3 - Bos taurus (Bovine) - ID3 gene Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Taurus_UMD|evm.model.AC_000159.1.959 Q8TDY4 ASAP3_HUMAN 88.269 0.978385 0.973422 ASAP3 - Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 - Homo sapiens (Human) - ASAP3 gene Promotes cell proliferation. Taurus_UMD|evm.model.AC_000159.1.960 Q2KI09 TCEA3_BOVIN 93.391 0.948087 1.04871 TCEA3 - Transcription elongation factor A protein 3 - Bos taurus (Bovine) - TCEA3 gene Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity). Taurus_UMD|evm.model.AC_000159.1.961 Q5R5Y7 ZN436_PONAB 96.809 0.995754 1.00213 ZNF436 - Zinc finger protein 436 - Pongo abelii (Sumatran orangutan) - ZNF436 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000159.1.962 O43390 HNRPR_HUMAN 99.842 0.996845 1.00158 HNRNPR - Heterogeneous nuclear ribonucleoprotein R - Homo sapiens (Human) - HNRNPR gene Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. Taurus_UMD|evm.model.AC_000159.1.963 P79400 5HT1D_PIG 95.189 0.767196 1.29897 HTR1D - 5-hydroxytryptamine receptor 1D - Sus scrofa (Pig) - HTR1D gene G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction (By similarity). Taurus_UMD|evm.model.AC_000159.1.964 Q9NY97 B3GN2_HUMAN 82.090 0.923611 0.36272 B3GNT2 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 - Homo sapiens (Human) - B3GNT2 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. Taurus_UMD|evm.model.AC_000159.1.965 Q86V48 LUZP1_HUMAN 84.494 0.998134 0.996283 LUZP1 - Leucine zipper protein 1 - Homo sapiens (Human) - LUZP1 gene extracellular exosome, membrane, neural fold bending Taurus_UMD|evm.model.AC_000159.1.966 Q6ZQ88 KDM1A_MOUSE 96.449 0.997712 1.02462 Kdm1a - Lysine-specific histone demethylase 1A - Mus musculus (Mouse) - Kdm1a gene Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation (By similarity). Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. Taurus_UMD|evm.model.AC_000159.1.967 H3BTG2 TEX46_HUMAN 60.526 0.92638 1.34711 TEX46 - Testis-expressed protein 46 precursor - Homo sapiens (Human) - TEX46 gene Taurus_UMD|evm.model.AC_000159.1.968 A8MY62 BLML_HUMAN 86.654 0.883562 1.168 LACTBL1 - Putative beta-lactamase-like 1 - Homo sapiens (Human) - LACTBL1 gene Taurus_UMD|evm.model.AC_000159.1.969 P29323 EPHB2_HUMAN 94.825 0.847395 0.763981 EPHB2 - Ephrin type-B receptor 2 precursor - Homo sapiens (Human) - EPHB2 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). Taurus_UMD|evm.model.AC_000159.1.970 P29323 EPHB2_HUMAN 99.123 0.729904 0.294787 EPHB2 - Ephrin type-B receptor 2 precursor - Homo sapiens (Human) - EPHB2 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). Taurus_UMD|evm.model.AC_000159.1.971 Q2KIV9 C1QB_BOVIN 99.000 0.961165 0.417004 C1QB - Complement C1q subcomponent subunit B precursor - Bos taurus (Bovine) - C1QB gene C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes (By similarity). Taurus_UMD|evm.model.AC_000159.1.972 Q2KIV9 C1QB_BOVIN 100.000 0.991935 1.00405 C1QB - Complement C1q subcomponent subunit B precursor - Bos taurus (Bovine) - C1QB gene C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes (By similarity). Taurus_UMD|evm.model.AC_000159.1.973 Q5RBU8 ROA2_PONAB 76.033 0.421053 0.807365 HNRNPA2B1 - Heterogeneous nuclear ribonucleoproteins A2/B1 - Pongo abelii (Sumatran orangutan) - HNRNPA2B1 gene Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (By similarity). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (By similarity). Taurus_UMD|evm.model.AC_000159.1.974 P02747 C1QC_HUMAN 78.733 0.901639 0.995918 C1QC - Complement C1q subcomponent subunit C precursor - Homo sapiens (Human) - C1QC gene C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Taurus_UMD|evm.model.AC_000159.1.975 Q5E9E3 C1QA_BOVIN 100.000 0.727545 1.36885 C1QA - Complement C1q subcomponent subunit A precursor - Bos taurus (Bovine) - C1QA gene C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Taurus_UMD|evm.model.AC_000159.1.976 P29322 EPHA8_HUMAN 97.331 0.995906 0.972139 EPHA8 - Ephrin type-A receptor 8 precursor - Homo sapiens (Human) - EPHA8 gene Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). Taurus_UMD|evm.model.AC_000159.1.977 Q9NUA8 ZBT40_HUMAN 83.280 0.998384 0.999193 ZBTB40 - Zinc finger and BTB domain-containing protein 40 - Homo sapiens (Human) - ZBTB40 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000159.1.979 P56705 WNT4_HUMAN 99.692 0.97006 0.951567 WNT4 - Protein Wnt-4 precursor - Homo sapiens (Human) - WNT4 gene Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung (PubMed:15317892, PubMed:16959810, PubMed:18179883, PubMed:18182450). Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development (By similarity). Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal lung development and for normal patterning of trachael cartilage rings (By similarity). Taurus_UMD|evm.model.AC_000159.1.980 Q4R4R6 CDC42_MACFA 100.000 0.986486 0.774869 CDC42 - Cell division control protein 42 homolog precursor - Macaca fascicularis (Crab-eating macaque) - CDC42 gene Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (By similarity). Taurus_UMD|evm.model.AC_000159.1.981 Q32PG5 SCND1_BOVIN 72.222 0.493056 0.808989 SCAND1 - SCAN domain-containing protein 1 - Bos taurus (Bovine) - SCAND1 gene May regulate transcriptional activity. Taurus_UMD|evm.model.AC_000159.1.982 P05805 CAC3_BOVIN 98.814 0.807692 1.2332 Proproteinase E precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000159.1.984 P98160 PGBM_HUMAN 89.023 0.994548 1.00251 HSPG2 - Basement membrane-specific heparan sulfate proteoglycan core protein precursor - Homo sapiens (Human) - HSPG2 gene Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Taurus_UMD|evm.model.AC_000159.1.985 Q5SZI1 LRAD2_HUMAN 75.309 0.695402 1.27941 LDLRAD2 - Low-density lipoprotein receptor class A domain-containing protein 2 precursor - Homo sapiens (Human) - LDLRAD2 gene Taurus_UMD|evm.model.AC_000159.1.986 Q86UV5 UBP48_HUMAN 97.683 0.998071 1.00193 USP48 - Ubiquitin carboxyl-terminal hydrolase 48 - Homo sapiens (Human) - USP48 gene Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Taurus_UMD|evm.model.AC_000159.1.987 P47736 RPGP1_HUMAN 98.039 0.909341 1.09804 RAP1GAP - Rap1 GTPase-activating protein 1 - Homo sapiens (Human) - RAP1GAP gene GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. Taurus_UMD|evm.model.AC_000159.1.988 P09487 PPBT_BOVIN 100.000 0.99619 1.00191 ALPL - Alkaline phosphatase, tissue-nonspecific isozyme precursor - Bos taurus (Bovine) - ALPL gene This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi). Taurus_UMD|evm.model.AC_000159.1.989 P42891 ECE1_BOVIN 100.000 0.997351 1.00133 ECE1 - Endothelin-converting enzyme 1 - Bos taurus (Bovine) - ECE1 gene Converts big endothelin-1 to endothelin-1. Taurus_UMD|evm.model.AC_000159.1.990 O43432 IF4G3_HUMAN 90.470 0.807 0.630915 EIF4G3 - Eukaryotic translation initiation factor 4 gamma 3 - Homo sapiens (Human) - EIF4G3 gene Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1. Taurus_UMD|evm.model.AC_000159.1.991 Q08DU9 HP1B3_BOVIN 100.000 0.996403 1.0018 HP1BP3 - Heterochromatin protein 1-binding protein 3 - Bos taurus (Bovine) - HP1BP3 gene Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. May play a role in hypoxia-induced oncogenesis. Taurus_UMD|evm.model.AC_000159.1.992 Q6ZV89 SH2D5_HUMAN 89.953 0.995338 1.01418 SH2D5 - SH2 domain-containing protein 5 - Homo sapiens (Human) - SH2D5 gene May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. Taurus_UMD|evm.model.AC_000159.1.993 Q9P2E2 KIF17_HUMAN 77.559 0.998102 1.0243 KIF17 - Kinesin-like protein KIF17 - Homo sapiens (Human) - KIF17 gene Dendrite-specific motor protein which, in association with the Apba1-containing complex (LIN-10-LIN-2-LIN-7 complex), transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. Taurus_UMD|evm.model.AC_000159.1.994 A6QPY0 OST48_BOVIN 92.483 0.781853 1.17995 DDOST - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor - Bos taurus (Bovine) - DDOST gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity). Taurus_UMD|evm.model.AC_000159.1.995 Q9BXM7 PINK1_HUMAN 86.130 0.988115 1.01377 PINK1 - Serine/threonine-protein kinase PINK1, mitochondrial precursor - Homo sapiens (Human) - PINK1 gene Serine/threonine-protein kinase which protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins such as PRKN and DNM1L, to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:14607334, PubMed:18957282, PubMed:18443288, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:22396657, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24898855, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291, PubMed:32484300, PubMed:20547144). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:18443288, PubMed:23620051, PubMed:24898855, PubMed:20798600, PubMed:20404107, PubMed:19966284, PubMed:32484300, PubMed:22396657, PubMed:32047033, PubMed:15087508). Mediates the translocation and activation of PRKN at the outer membrane (OMM) of dysfunctional/depolarized mitochondria (PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23754282, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25474007, PubMed:25527291). At the OMM of damaged mitochondria, phosphorylates pre-existing polyubiquitin chains at 'Ser-65', the PINK1-phosphorylated polyubiquitin then recruits PRKN from the cytosol to the OMM where PRKN is fully activated by phosphorylation at 'Ser-65' by PINK1 (PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23754282, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25474007, PubMed:25527291). In damaged mitochondria, mediates the decision between mitophagy or preventing apoptosis by promoting PRKN-dependent poly- or monoubiquitination of VDAC1; polyubiquitination of VDAC1 by PRKN promotes mitophagy, while monoubiquitination of VDAC1 by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). When cellular stress results in irreversible mitochondrial damage, functions with PRKN to promote clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:14607334, PubMed:20798600, PubMed:20404107, PubMed:19966284, PubMed:23933751, PubMed:15087508). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by phosphorylating and thus promoting the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:18443288, PubMed:23620051, PubMed:24898855). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:18443288, PubMed:23620051). Also promotes mitochondrial fission independently of PRKN and ATG7-mediated mitophagy, via the phosphorylation and activation of DNM1L (PubMed:18443288, PubMed:32484300). Regulates motility of damaged mitochondria by promoting the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity). Taurus_UMD|evm.model.AC_000159.1.996 P56389 CDD_MOUSE 90.411 0.986395 1.00685 Cda - Cytidine deaminase - Mus musculus (Mouse) - Cda gene This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Taurus_UMD|evm.model.AC_000159.1.998 Q6ZT52 FA43B_HUMAN 90.634 0.993827 0.984802 FAM43B - Protein FAM43B - Homo sapiens (Human) - FAM43B gene Taurus_UMD|evm.model.AC_000159.1.999 Q969V5 MUL1_HUMAN 83.003 0.994302 0.997159 MUL1 - Mitochondrial ubiquitin ligase activator of NFKB 1 - Homo sapiens (Human) - MUL1 gene Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (PubMed:22410793). Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion (PubMed:21597459). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395). Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830). Inhibits cell growth (PubMed:18591963, PubMed:22410793). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697). Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response (PubMed:23399697). Can mediate DDX58 sumoylation and disrupt its polyubiquitination (PubMed:23399697). Taurus_UMD|evm.model.AC_000159.1.1000 A7MBG3 CK2N1_BOVIN 100.000 0.974684 1.01282 CAMK2N1 - Calcium/calmodulin-dependent protein kinase II inhibitor 1 - Bos taurus (Bovine) - CAMK2N1 gene Potent and specific inhibitor of CaM-kinase II (CAMK2). Taurus_UMD|evm.model.AC_000159.1.1001 Q5TIE3 VW5B1_HUMAN 77.746 0.302596 0.915574 VWA5B1 - von Willebrand factor A domain-containing protein 5B1 precursor - Homo sapiens (Human) - VWA5B1 gene Taurus_UMD|evm.model.AC_000159.1.1002 Q96LJ8 UBX10_HUMAN 72.857 0.989362 1.00714 UBXN10 - UBX domain-containing protein 10 - Homo sapiens (Human) - UBXN10 gene VCP/p97-binding protein required for ciliogenesis (PubMed:26389662). Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia (PubMed:26389662). UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97 (PubMed:26389662). Taurus_UMD|evm.model.AC_000159.1.1003 P39878 PA2GC_RAT 67.763 0.986842 1.01333 Pla2g2c - Group IIC secretory phospholipase A2 precursor - Rattus norvegicus (Rat) - Pla2g2c gene PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Taurus_UMD|evm.model.AC_000159.1.1005 Q9BZM2 PA2GF_HUMAN 78.289 0.611336 1.47024 PLA2G2F - Group IIF secretory phospholipase A2 precursor - Homo sapiens (Human) - PLA2G2F gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids (phospholipase A2 activity), the catalytic efficiency decreasing in the following order: phosphatidylglycerols > phosphatidylethanolamines > phosphatidylcholines > phosphatidylserines (PubMed:11112443). May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity). Taurus_UMD|evm.model.AC_000159.1.1006 Q9UNK4 PA2GD_HUMAN 60.690 0.959459 1.02069 PLA2G2D - Group IID secretory phospholipase A2 precursor - Homo sapiens (Human) - PLA2G2D gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions (PubMed:10455175, PubMed:10681567). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:10455175). In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins (By similarity). During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response (By similarity). May act in an autocrine and paracrine manner (By similarity). Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance (By similarity). May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (By similarity). Taurus_UMD|evm.model.AC_000159.1.1007 Q9UNK4 PA2GD_HUMAN 59.310 0.739583 1.32414 PLA2G2D - Group IID secretory phospholipase A2 precursor - Homo sapiens (Human) - PLA2G2D gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions (PubMed:10455175, PubMed:10681567). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:10455175). In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins (By similarity). During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response (By similarity). May act in an autocrine and paracrine manner (By similarity). Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance (By similarity). May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (By similarity). Taurus_UMD|evm.model.AC_000159.1.1008 P39877 PA2G5_HUMAN 73.913 0.931973 1.06522 PLA2G5 - Phospholipase A2 group V precursor - Homo sapiens (Human) - PLA2G5 gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:8300559). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups (PubMed:8300559, PubMed:14998370, PubMed:23533611). Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (By similarity). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes (PubMed:23533611). Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines (PubMed:25725101). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (By similarity). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells (PubMed:12124392, PubMed:12796497). In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way (PubMed:12796497). In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A (PubMed:12124392). Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis (By similarity). May regulate antigen processing in antigen-presenting cells (By similarity). In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (PubMed:14998370). Taurus_UMD|evm.model.AC_000159.1.1009 Q56JZ2 PA2GA_BOVIN 100.000 0.665116 1.49306 PLA2G2A - Phospholipase A2, membrane associated precursor - Bos taurus (Bovine) - PLA2G2A gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration (By similarity). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane. Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes. Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response (By similarity). Plays a stem cell regulator role in the intestinal crypt. Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000159.1.1011 Q56JZ2 PA2GA_BOVIN 68.056 0.986207 1.00694 PLA2G2A - Phospholipase A2, membrane associated precursor - Bos taurus (Bovine) - PLA2G2A gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration (By similarity). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane. Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes. Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response (By similarity). Plays a stem cell regulator role in the intestinal crypt. Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000159.1.1012 Q9QUL3 PA2GE_MOUSE 86.620 0.986014 1.00704 Pla2g2e - Group IIE secretory phospholipase A2 precursor - Mus musculus (Mouse) - Pla2g2e gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:11922621, PubMed:10531313). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), releasing various unsaturated fatty acids including oleoate, linoleoate, arachidonate, docosahexaenoate and lysophosphatidylethanolamines in preference to lysophosphatidylcholines (By similarity). In response to high-fat diet, hydrolyzes minor lipoprotein phospholipids including phosphatidylserines, phosphatidylinositols and phosphatidylglycerols, altering lipoprotein composition and fat storage in adipose tissue and liver (PubMed:24910243). May act in an autocrine and paracrine manner (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria (By similarity). Acts as a hair follicle phospholipase A2. Selectively releases lysophosphatidylethanolamines (LPE) and various unsaturated fatty acids in skin to regulate hair follicle homeostasis (PubMed:27226633). May regulate the inflammatory response by releasing arachidonate, a precursor of prostaglandins and leukotrienes. Upon allergen exposure, may participate in allergic inflammatory response by enhancing leukotriene C4 synthesis and degranulation in mast cells (PubMed:11922621). Taurus_UMD|evm.model.AC_000159.1.1014 Q5T2D3 OTUD3_HUMAN 89.950 0.994975 1 OTUD3 - OTU domain-containing protein 3 - Homo sapiens (Human) - OTUD3 gene Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Taurus_UMD|evm.model.AC_000159.1.1015 Q3T0Y9 RN186_BOVIN 99.558 0.991189 1.00442 RNF186 - E3 ubiquitin-protein ligase RNF186 - Bos taurus (Bovine) - RNF186 gene E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. In that process, stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis. Taurus_UMD|evm.model.AC_000159.1.1017 Q5TGY1 TMCO4_HUMAN 87.821 0.984202 0.998423 TMCO4 - Transmembrane and coiled-coil domain-containing protein 4 - Homo sapiens (Human) - TMCO4 gene Taurus_UMD|evm.model.AC_000159.1.1018 P31388 5HT6R_RAT 86.377 0.770142 0.96789 Htr6 - 5-hydroxytryptamine receptor 6 - Rattus norvegicus (Rat) - Htr6 gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (PubMed:7680751). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (By similarity). Taurus_UMD|evm.model.AC_000159.1.1019 P41271 NBL1_HUMAN 93.333 0.988701 0.977901 NBL1 - Neuroblastoma suppressor of tumorigenicity 1 precursor - Homo sapiens (Human) - NBL1 gene Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process. Taurus_UMD|evm.model.AC_000159.1.1020 Q5TGZ0 MIC10_HUMAN 96.154 0.974684 1.01282 MICOS10 - MICOS complex subunit MIC10 - Homo sapiens (Human) - MICOS10 gene Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Taurus_UMD|evm.model.AC_000159.1.1021 P47756 CAPZB_HUMAN 98.188 0.895765 1.1083 CAPZB - F-actin-capping protein subunit beta - Homo sapiens (Human) - CAPZB gene F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Taurus_UMD|evm.model.AC_000159.1.1022 Q6ZP29 LAAT1_HUMAN 84.880 0.993151 1.00344 SLC66A1 - Lysosomal amino acid transporter 1 homolog - Homo sapiens (Human) - SLC66A1 gene Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. Taurus_UMD|evm.model.AC_000159.1.1023 O43488 ARK72_HUMAN 90.295 0.816609 0.805014 AKR7A2 - Aflatoxin B1 aldehyde reductase member 2 - Homo sapiens (Human) - AKR7A2 gene Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Taurus_UMD|evm.model.AC_000159.1.1024 O95154 ARK73_HUMAN 78.550 0.954955 1.00604 AKR7A3 - Aflatoxin B1 aldehyde reductase member 3 - Homo sapiens (Human) - AKR7A3 gene Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Taurus_UMD|evm.model.AC_000159.1.1025 O43488 ARK72_HUMAN 59.509 0.622549 0.568245 AKR7A2 - Aflatoxin B1 aldehyde reductase member 2 - Homo sapiens (Human) - AKR7A2 gene Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Taurus_UMD|evm.model.AC_000159.1.1026 A4FV84 MRT4_BOVIN 100.000 0.991667 1.00418 MRTO4 - mRNA turnover protein 4 homolog - Bos taurus (Bovine) - MRTO4 gene Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. Taurus_UMD|evm.model.AC_000159.1.1027 Q8N766 EMC1_HUMAN 93.656 0.997986 1 EMC1 - ER membrane protein complex subunit 1 precursor - Homo sapiens (Human) - EMC1 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). Taurus_UMD|evm.model.AC_000159.1.1028 Q5T4S7 UBR4_HUMAN 96.836 0.999614 0.999807 UBR4 - E3 ubiquitin-protein ligase UBR4 - Homo sapiens (Human) - UBR4 gene E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. Taurus_UMD|evm.model.AC_000159.1.1029 P0C6R4 IFFO2_RAT 97.561 0.605932 1.6446 Iffo2 - Intermediate filament family orphan 2 - Rattus norvegicus (Rat) - Iffo2 gene Taurus_UMD|evm.model.AC_000159.1.1030 A7YWE4 AL4A1_BOVIN 100.000 0.996454 1.00178 ALDH4A1 - Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ALDH4A1 gene Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). Taurus_UMD|evm.model.AC_000159.1.1031 Q49HI0 TS1R2_CANLF 76.667 0.231373 0.305024 TAS1R2 - Taste receptor type 1 member 2 precursor - Canis lupus familiaris (Dog) - TAS1R2 gene Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners (By similarity). Taurus_UMD|evm.model.AC_000159.1.1032 Q49HI0 TS1R2_CANLF 77.551 0.825581 1.13158 TAS1R2 - Taste receptor type 1 member 2 precursor - Canis lupus familiaris (Dog) - TAS1R2 gene Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners (By similarity). Taurus_UMD|evm.model.AC_000159.1.1036 P23759 PAX7_HUMAN 98.071 0.914454 0.671287 PAX7 - Paired box protein Pax-7 - Homo sapiens (Human) - PAX7 gene Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration. Taurus_UMD|evm.model.AC_000159.1.1039 Q5R866 KLD7A_PONAB 68.575 0.983689 1.03776 KLHDC7A - Kelch domain-containing protein 7A - Pongo abelii (Sumatran orangutan) - KLHDC7A gene Taurus_UMD|evm.model.AC_000159.1.1041 Q7TNR6 IGS21_MOUSE 85.421 0.993865 1.04487 Igsf21 - Immunoglobulin superfamily member 21 precursor - Mus musculus (Mouse) - Igsf21 gene Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2. Taurus_UMD|evm.model.AC_000159.1.1042 Q9H568 ACTL8_HUMAN 72.131 0.994536 1 ACTL8 - Actin-like protein 8 - Homo sapiens (Human) - ACTL8 gene dynactin complex, epithelial cell differentiation Taurus_UMD|evm.model.AC_000159.1.1043 Q29RM4 ARGAL_BOVIN 99.919 0.998384 1.00081 ARHGEF10L - Rho guanine nucleotide exchange factor 10-like protein - Bos taurus (Bovine) - ARHGEF10L gene Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. Taurus_UMD|evm.model.AC_000159.1.1044 Q9P258 RCC2_HUMAN 98.276 0.996161 0.998084 RCC2 - Protein RCC2 - Homo sapiens (Human) - RCC2 gene Multifunctional protein that may effect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed:12919680, PubMed:25074804, PubMed:26158537, PubMed:28869598). Required for normal progress through the cell cycle, both during interphase and during mitosis (PubMed:23388455, PubMed:12919680, PubMed:26158537). Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles (PubMed:12919680, PubMed:26158537). Required for normal organization of the microtubule cytoskeleton in interphase cells (PubMed:23388455). Functions as guanine nucleotide exchange factor (GEF) for RALA (PubMed:26158537). Interferes with the activation of RAC1 by guanine nucleotide exchange factors (PubMed:25074804). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804, PubMed:28869598). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (PubMed:25074804, PubMed:28869598). Taurus_UMD|evm.model.AC_000159.1.1045 Q6TGC4 PADI6_HUMAN 70.520 0.997097 0.992795 PADI6 - Protein-arginine deiminase type-6 - Homo sapiens (Human) - PADI6 gene Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:27545678). Taurus_UMD|evm.model.AC_000159.1.1046 Q9UM07 PADI4_HUMAN 73.763 0.996997 1.00452 PADI4 - Protein-arginine deiminase type-4 - Homo sapiens (Human) - PADI4 gene Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci) (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532). Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci (PubMed:18209087). Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription (PubMed:15345777). Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1 (PubMed:15731352). Taurus_UMD|evm.model.AC_000159.1.1047 O02849 PADI3_SHEEP 92.018 0.996992 1.00151 PADI3 - Protein-arginine deiminase type-3 - Ovis aries (Sheep) - PADI3 gene Catalyzes the deimination of arginine residues of proteins. Taurus_UMD|evm.model.AC_000159.1.1048 Q9ULC6 PADI1_HUMAN 77.323 0.943452 1.01357 PADI1 - Protein-arginine deiminase type-1 - Homo sapiens (Human) - PADI1 gene Catalyzes the deimination of arginine residues of proteins. Taurus_UMD|evm.model.AC_000159.1.1051 Q9Y2J8 PADI2_HUMAN 92.180 0.996997 1.0015 PADI2 - Protein-arginine deiminase type-2 - Homo sapiens (Human) - PADI2 gene Catalyzes the deimination of arginine residues of proteins. Taurus_UMD|evm.model.AC_000159.1.1052 Q3T189 SDHB_BOVIN 100.000 0.975524 1.02143 SDHB - Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor - Bos taurus (Bovine) - SDHB gene Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Taurus_UMD|evm.model.AC_000159.1.1053 Q9NQ11 AT132_HUMAN 83.814 0.998294 0.99322 ATP13A2 - Polyamine-transporting ATPase 13A2 - Homo sapiens (Human) - ATP13A2 gene ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine (PubMed:31996848). Also stimulates cellular uptake of polyamines and protects against polyamine toxicity (PubMed:31996848). Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (PubMed:22186024). Contributes to cellular zinc homeostasis (PubMed:24603074). Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress (PubMed:26134396). Required for proper lysosomal and mitochondrial maintenance (PubMed:22296644, PubMed:28137957). Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels (PubMed:27278822). Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Promotes secretion of exosomes as well as secretion of SCNA via exosomes (PubMed:25392495, PubMed:24603074). Plays a role in lipid homeostasis (PubMed:31132336). Taurus_UMD|evm.model.AC_000159.1.1054 P27424 MFAP2_BOVIN 99.454 0.98913 1.00546 MFAP2 - Microfibrillar-associated protein 2 precursor - Bos taurus (Bovine) - MFAP2 gene Component of the elastin-associated microfibrils. Taurus_UMD|evm.model.AC_000159.1.1055 Q5E9Q4 NECP2_BOVIN 96.567 0.0971118 8.9812 NECAP2 - Adaptin ear-binding coat-associated protein 2 - Bos taurus (Bovine) - NECAP2 gene Involved in endocytosis. Taurus_UMD|evm.model.AC_000159.1.1056 Q7Z572 SPT21_HUMAN 62.393 0.650499 1.49467 SPATA21 - Spermatogenesis-associated protein 21 - Homo sapiens (Human) - SPATA21 gene Involved in the differentiation of haploid spermatids. Taurus_UMD|evm.model.AC_000159.1.1057 Q2KI04 SZRD1_BOVIN 100.000 0.986928 1.00658 SZRD1 - SUZ domain-containing protein 1 - Bos taurus (Bovine) - SZRD1 gene Taurus_UMD|evm.model.AC_000159.1.1058 Q6P3S6 FBX42_HUMAN 95.119 0.923871 1.08089 FBXO42 - F-box only protein 42 - Homo sapiens (Human) - FBXO42 gene Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. Taurus_UMD|evm.model.AC_000159.1.1059 Q9BU20 CPLN2_HUMAN 92.213 0.609572 1.53876 CPLANE2 - Ciliogenesis and planar polarity effector 2 - Homo sapiens (Human) - CPLANE2 gene Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity). Taurus_UMD|evm.model.AC_000159.1.1060 Q8IW93 ARHGJ_HUMAN 89.604 0.997525 1.00748 ARHGEF19 - Rho guanine nucleotide exchange factor 19 - Homo sapiens (Human) - ARHGEF19 gene Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Taurus_UMD|evm.model.AC_000159.1.1061 P29317 EPHA2_HUMAN 93.340 0.997951 1 EPHA2 - Ephrin type-A receptor 2 precursor - Homo sapiens (Human) - EPHA2 gene Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. Taurus_UMD|evm.model.AC_000159.1.1063 Q96AQ9 F131C_HUMAN 70.076 0.991935 0.885714 FAM131C - Protein FAM131C - Homo sapiens (Human) - FAM131C gene Taurus_UMD|evm.model.AC_000159.1.1064 P51803 CLCKA_RABIT 87.773 0.997093 1.00146 CLCNKA - Chloride channel protein ClC-Ka - Oryctolagus cuniculus (Rabbit) - CLCNKA gene Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. Taurus_UMD|evm.model.AC_000159.1.1066 Q9UBY9 HSPB7_HUMAN 87.931 0.988235 1 HSPB7 - Heat shock protein beta-7 - Homo sapiens (Human) - HSPB7 gene aggresome, cytoplasm, nucleoplasm, nucleus, protein C-terminus binding, regulation of heart contraction, response to unfolded protein Taurus_UMD|evm.model.AC_000159.1.1067 Q8NEQ6 SRARP_HUMAN 49.500 0.965174 1.18935 SRARP - Steroid receptor-associated and regulated protein - Homo sapiens (Human) - SRARP gene May regulate the transcriptional function of androgen and estrogen receptors. Taurus_UMD|evm.model.AC_000159.1.1068 C9J2P7 U17LF_HUMAN 38.298 0.93 0.180832 USP17L15 - Ubiquitin carboxyl-terminal hydrolase 17-like protein 15 - Homo sapiens (Human) - USP17L15 gene Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. Taurus_UMD|evm.model.AC_000159.1.1072 Q6NXG1 ESRP1_HUMAN 96.804 0.653386 1.4743 ESRP1 - Epithelial splicing regulatory protein 1 - Homo sapiens (Human) - ESRP1 gene mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). Taurus_UMD|evm.model.AC_000159.1.1080 C9JVI0 U17LB_HUMAN 33.714 0.483871 0.643396 USP17L11 - Ubiquitin carboxyl-terminal hydrolase 17-like protein 11 - Homo sapiens (Human) - USP17L11 gene Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. Taurus_UMD|evm.model.AC_000159.1.1081 A6NCW0 U17L3_HUMAN 32.857 0.372727 0.622642 USP17L3 - Ubiquitin carboxyl-terminal hydrolase 17-like protein 3 - Homo sapiens (Human) - USP17L3 gene Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. Taurus_UMD|evm.model.AC_000160.1.4 Q8NGM1 OR4CF_HUMAN 58.140 0.736842 0.18038 OR4C15 - Olfactory receptor 4C15 - Homo sapiens (Human) - OR4C15 gene Odorant receptor. Taurus_UMD|evm.model.AC_000160.1.6 Q9DGD1 MGT4C_CHICK 45.178 0.841542 1.00647 MGAT4C - Alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase - Gallus gallus (Chicken) - MGAT4C gene Glycosyltransferase that catalyzes the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (also named 'GnT-VI' activity). May also participate in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans by catalyzing the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Taurus_UMD|evm.model.AC_000160.1.7 Q5XNS0 TBX19_CANLF 93.216 0.938534 0.950562 TBX19 - T-box transcription factor TBX19 - Canis lupus familiaris (Dog) - TBX19 gene Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters (By similarity). Taurus_UMD|evm.model.AC_000160.1.8 O95562 SFT2B_HUMAN 90.000 0.987578 1.00625 SFT2D2 - Vesicle transport protein SFT2B - Homo sapiens (Human) - SFT2D2 gene May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Taurus_UMD|evm.model.AC_000160.1.9 Q8BH58 TIPRL_MOUSE 97.426 0.992674 1.00738 Tiprl - TIP41-like protein - Mus musculus (Mouse) - Tiprl gene May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair (By similarity). Taurus_UMD|evm.model.AC_000160.1.10 Q2YDN1 GP161_BOVIN 95.455 0.996117 0.975379 GPR161 - G protein-coupled receptor 161 - Bos taurus (Bovine) - GPR161 gene Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). Taurus_UMD|evm.model.AC_000160.1.12 Q5R9B8 DCAF6_PONAB 96.522 0.490909 1.08721 DCAF6 - DDB1- and CUL4-associated factor 6 - Pongo abelii (Sumatran orangutan) - DCAF6 gene Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). Taurus_UMD|evm.model.AC_000160.1.13 O95563 MPC2_HUMAN 96.063 0.984375 1.00787 MPC2 - Mitochondrial pyruvate carrier 2 - Homo sapiens (Human) - MPC2 gene Mediates the uptake of pyruvate into mitochondria. Taurus_UMD|evm.model.AC_000160.1.14 Q866F4 ADCYA_RABIT 86.121 0.998762 1.00311 ADCY10 - Adenylate cyclase type 10 - Oryctolagus cuniculus (Rabbit) - ADCY10 gene Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity). Taurus_UMD|evm.model.AC_000160.1.15 Q32PI9 MPZL1_BOVIN 100.000 0.992593 1.00372 MPZL1 - Myelin protein zero-like protein 1 precursor - Bos taurus (Bovine) - MPZL1 gene Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. May be involved in regulation of integrin-mediated cell motility (By similarity). Taurus_UMD|evm.model.AC_000160.1.16 Q3ZBT0 CPZIP_BOVIN 99.738 0.994764 1.00262 RCSD1 - CapZ-interacting protein - Bos taurus (Bovine) - RCSD1 gene Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. Taurus_UMD|evm.model.AC_000160.1.17 O75629 CREG1_HUMAN 82.353 0.990991 1.00909 CREG1 - Protein CREG1 precursor - Homo sapiens (Human) - CREG1 gene May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R. Taurus_UMD|evm.model.AC_000160.1.18 P29329 CD3Z_SHEEP 95.181 0.988024 1.00602 CD247 - T-cell surface glycoprotein CD3 zeta chain precursor - Ovis aries (Sheep) - CD247 gene Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN). Taurus_UMD|evm.model.AC_000160.1.19 Q29076 PO2F1_PIG 97.181 0.96749 1.03221 POU2F1 - POU domain, class 2, transcription factor 1 - Sus scrofa (Pig) - POU2F1 gene Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. Taurus_UMD|evm.model.AC_000160.1.20 Q5VZP5 STYL2_HUMAN 84.423 0.998274 1.00086 STYXL2 - Serine/threonine/tyrosine-interacting-like protein 2 - Homo sapiens (Human) - STYXL2 gene May be required for myofiber maturation. Taurus_UMD|evm.model.AC_000160.1.21 Q99795 GPA33_HUMAN 71.711 0.952532 0.990596 GPA33 - Cell surface A33 antigen precursor - Homo sapiens (Human) - GPA33 gene May play a role in cell-cell recognition and signaling. Taurus_UMD|evm.model.AC_000160.1.22 Q90835 EF1A_CHICK 50.769 0.196319 0.705628 EEF1A - Elongation factor 1-alpha 1 - Gallus gallus (Chicken) - EEF1A gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Taurus_UMD|evm.model.AC_000160.1.23 Q32KV2 MAEL_BOVIN 94.524 0.995 0.952381 MAEL - Protein maelstrom homolog - Bos taurus (Bovine) - MAEL gene Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity). Taurus_UMD|evm.model.AC_000160.1.24 Q71H61 ILDR2_HUMAN 87.812 0.996785 0.973396 ILDR2 - Immunoglobulin-like domain-containing receptor 2 precursor - Homo sapiens (Human) - ILDR2 gene May be involved in lipid homeostasis and ER stress pathways. Taurus_UMD|evm.model.AC_000160.1.25 A6QR06 TADA1_BOVIN 100.000 0.994048 1.00299 TADA1 - Transcriptional adapter 1 - Bos taurus (Bovine) - TADA1 gene Probably involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000160.1.26 Q9P215 POGK_HUMAN 95.567 0.996721 1.00164 POGK - Pogo transposable element with KRAB domain - Homo sapiens (Human) - POGK gene nucleoplasm, nucleus, DNA binding Taurus_UMD|evm.model.AC_000160.1.27 P49109 FMO5_CAVPO 56.322 0.521212 0.309568 FMO5 - Flavin-containing monooxygenase 5 - Cavia porcellus (Guinea pig) - FMO5 gene Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters (By similarity). Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (PubMed:7872795). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (By similarity). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity). Taurus_UMD|evm.model.AC_000160.1.28 Q8K4C0 FMO5_RAT 54.615 0.938406 1.03565 Fmo5 - Flavin-containing monooxygenase 5 - Rattus norvegicus (Rat) - Fmo5 gene Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (By similarity). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity). Taurus_UMD|evm.model.AC_000160.1.29 Q32LC9 ZN330_BOVIN 94.615 0.854305 0.471875 ZNF330 - Zinc finger protein 330 - Bos taurus (Bovine) - ZNF330 gene nucleus Taurus_UMD|evm.model.AC_000160.1.30 Q8BQN5 FA78B_MOUSE 98.394 0.976378 0.97318 Fam78b - Protein FAM78B - Mus musculus (Mouse) - Fam78b gene Taurus_UMD|evm.model.AC_000160.1.31 Q9QYG8 UCK2_RAT 94.286 0.97992 0.954023 Uck2 - Uridine-cytidine kinase 2 - Rattus norvegicus (Rat) - Uck2 gene Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (By similarity). Taurus_UMD|evm.model.AC_000160.1.32 Q9QYG8 UCK2_RAT 100.000 0.203822 0.601533 Uck2 - Uridine-cytidine kinase 2 - Rattus norvegicus (Rat) - Uck2 gene Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (By similarity). Taurus_UMD|evm.model.AC_000160.1.33 Q5I0H4 TMCO1_RAT 100.000 0.989418 1.00532 Tmco1 - Calcium load-activated calcium channel - Rattus norvegicus (Rat) - Tmco1 gene Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum (ER) overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Together with SEC61 and TMEM147, forms the lipid-filled cavity at the center of the translocon where TMEM147 may insert hydrophobic segments of mutli-pass membrane proteins from the lumen into de central membrane cavity in a process gated by SEC61, and TMCO1 may insert hydrophobic segments of nascent chains from the cytosol into the cavity. Taurus_UMD|evm.model.AC_000160.1.34 Q2KJH9 AL9A1_BOVIN 99.798 0.946257 1.05466 ALDH9A1 - 4-trimethylaminobutyraldehyde dehydrogenase - Bos taurus (Bovine) - ALDH9A1 gene Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Taurus_UMD|evm.model.AC_000160.1.35 Q3T100 MGST3_BOVIN 100.000 0.853107 1.16447 MGST3 - Microsomal glutathione S-transferase 3 - Bos taurus (Bovine) - MGST3 gene Also functions as a glutathione peroxidase. Taurus_UMD|evm.model.AC_000160.1.36 Q8N7C0 LRC52_HUMAN 76.238 0.993421 0.971246 LRRC52 - Leucine-rich repeat-containing protein 52 precursor - Homo sapiens (Human) - LRRC52 gene Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. KCNU1 channel auxiliary protein. May modulate KCNU1 gating properties. Taurus_UMD|evm.model.AC_000160.1.37 Q0VC20 RXRG_BOVIN 100.000 0.99569 1.00216 RXRG - Retinoic acid receptor RXR-gamma - Bos taurus (Bovine) - RXRG gene Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). Taurus_UMD|evm.model.AC_000160.1.38 Q04650 LMX1A_MESAU 97.753 0.77193 0.298429 LMX1A - LIM homeobox transcription factor 1-alpha - Mesocricetus auratus (Golden hamster) - LMX1A gene Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity). Taurus_UMD|evm.model.AC_000160.1.39 Q9JKU8 LMX1A_MOUSE 100.000 0.48125 0.418848 Lmx1a - LIM homeobox transcription factor 1-alpha - Mus musculus (Mouse) - Lmx1a gene Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae. Taurus_UMD|evm.model.AC_000160.1.40 Q8TE12 LMX1A_HUMAN 96.313 0.964286 0.586387 LMX1A - LIM homeobox transcription factor 1-alpha - Homo sapiens (Human) - LMX1A gene Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity). Taurus_UMD|evm.model.AC_000160.1.41 P41778 PBX1_MOUSE 100.000 0.980344 0.946512 Pbx1 - Pre-B-cell leukemia transcription factor 1 - Mus musculus (Mouse) - Pbx1 gene Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (By similarity). Binds the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (By similarity). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 (PubMed:7791786). Acts as a transcriptional activator of PF4 in complex with MEIS1 (By similarity). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (PubMed:19799567). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (PubMed:32190943). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (PubMed:7913464). Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4 (By similarity). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (PubMed:22560297). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297). Taurus_UMD|evm.model.AC_000160.1.42 P20821 GCSH_BOVIN 97.110 0.988506 1.00578 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Taurus_UMD|evm.model.AC_000160.1.43 Q5E9F0 GBG11_BOVIN 100.000 0.972973 1.0137 GNG11 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 precursor - Bos taurus (Bovine) - GNG11 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Taurus_UMD|evm.model.AC_000160.1.44 Q9BZD4 NUF2_HUMAN 91.540 0.927419 1.06897 NUF2 - Kinetochore protein Nuf2 - Homo sapiens (Human) - NUF2 gene Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Taurus_UMD|evm.model.AC_000160.1.45 Q29RM9 RGS4_BOVIN 100.000 0.990291 1.00488 RGS4 - Regulator of G-protein signaling 4 - Bos taurus (Bovine) - RGS4 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein (By similarity). Taurus_UMD|evm.model.AC_000160.1.46 Q3T0T8 RGS5_BOVIN 98.817 0.988235 0.939227 RGS5 - Regulator of G-protein signaling 5 - Bos taurus (Bovine) - RGS5 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity). Taurus_UMD|evm.model.AC_000160.1.47 Q1RMX6 CC190_BOVIN 99.663 0.983389 1.01689 CCDC190 - Coiled-coil domain-containing protein 190 - Bos taurus (Bovine) - CCDC190 gene Taurus_UMD|evm.model.AC_000160.1.48 P56937 DHB7_HUMAN 85.586 0.991045 0.982405 HSD17B7 - 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 - Homo sapiens (Human) - HSD17B7 gene Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:12574203, PubMed:12732193, PubMed:12829805, PubMed:20659585, PubMed:19772289, PubMed:11165030). Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:12574203, PubMed:12732193, PubMed:19772289). Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol (PubMed:12574203, PubMed:12732193, PubMed:19772289). Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation (PubMed:12574203, PubMed:12732193). Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (PubMed:12829805, PubMed:20659585, PubMed:11165030). Taurus_UMD|evm.model.AC_000160.1.49 Q16832 DDR2_HUMAN 97.427 0.997664 1.00117 DDR2 - Discoidin domain-containing receptor 2 precursor - Homo sapiens (Human) - DDR2 gene Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. Taurus_UMD|evm.model.AC_000160.1.50 Q16222 UAP1_HUMAN 96.169 0.996176 1.00192 UAP1 - UDP-N-acetylhexosamine pyrophosphorylase - Homo sapiens (Human) - UAP1 gene Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P. Taurus_UMD|evm.model.AC_000160.1.51 Q28918 STAR_BOVIN 98.596 0.993007 1.00351 STAR - Steroidogenic acute regulatory protein, mitochondrial precursor - Bos taurus (Bovine) - STAR gene Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). Taurus_UMD|evm.model.AC_000160.1.52 Q5RCY1 UHMK1_PONAB 99.761 0.995238 1.00239 UHMK1 - Serine/threonine-protein kinase Kist - Pongo abelii (Sumatran orangutan) - UHMK1 gene Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity). Taurus_UMD|evm.model.AC_000160.1.54 A6QLD2 OLM2B_BOVIN 99.737 0.997375 1.00395 OLFML2B - Olfactomedin-like protein 2B precursor - Bos taurus (Bovine) - OLFML2B gene Taurus_UMD|evm.model.AC_000160.1.55 P18850 ATF6A_HUMAN 92.424 0.99696 0.98209 ATF6 - Cyclic AMP-dependent transcription factor ATF-6 alpha - Homo sapiens (Human) - ATF6 gene Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane (PubMed:10564271, PubMed:11158310, PubMed:11779464). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:10564271, PubMed:11158310, PubMed:11779464). Taurus_UMD|evm.model.AC_000160.1.56 Q9UNI6 DUS12_HUMAN 82.789 0.971098 1.01765 DUSP12 - Dual specificity protein phosphatase 12 - Homo sapiens (Human) - DUSP12 gene Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476). Taurus_UMD|evm.model.AC_000160.1.57 Q6BAA4 FCRLB_HUMAN 86.385 0.995215 0.981221 FCRLB - Fc receptor-like B precursor - Homo sapiens (Human) - FCRLB gene cytoplasm, integral component of plasma membrane, transmembrane signaling receptor activity, cell surface receptor signaling pathway, negative regulation of immune response Taurus_UMD|evm.model.AC_000160.1.58 Q63273 GRIK5_RAT 55.491 0.648148 0.220633 Grik5 - Glutamate receptor ionotropic, kainate 5 precursor - Rattus norvegicus (Rat) - Grik5 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > glutamate >> AMPA. Taurus_UMD|evm.model.AC_000160.1.59 Q7L513 FCRLA_HUMAN 75.000 0.977465 0.988858 FCRLA - Fc receptor-like A precursor - Homo sapiens (Human) - FCRLA gene May be implicated in B-cell differentiation and lymphomagenesis. Taurus_UMD|evm.model.AC_000160.1.60 Q28110 FCGR2_BOVIN 93.671 0.993691 1.07095 FCGR2 - Low affinity immunoglobulin gamma Fc region receptor II precursor - Bos taurus (Bovine) - FCGR2 gene Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. Taurus_UMD|evm.model.AC_000160.1.61 P79107 FCGR3_BOVIN 98.800 0.992032 1.004 FCGR3 - Low affinity immunoglobulin gamma Fc region receptor III precursor - Bos taurus (Bovine) - FCGR3 gene Is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Also mediates antibody-dependent cellular toxicity (By similarity). Taurus_UMD|evm.model.AC_000160.1.62 Q04967 HSP76_PIG 95.179 0.996894 1.00156 HSPA6 - Heat shock 70 kDa protein 6 - Sus scrofa (Pig) - HSPA6 gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Taurus_UMD|evm.model.AC_000160.1.64 Q28110 FCGR2_BOVIN 94.907 0.926724 0.783784 FCGR2 - Low affinity immunoglobulin gamma Fc region receptor II precursor - Bos taurus (Bovine) - FCGR2 gene Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. Taurus_UMD|evm.model.AC_000160.1.67 Q3SZT6 FLTOP_BOVIN 100.000 0.989848 1.0051 CFAP126 - Protein Flattop - Bos taurus (Bovine) - CFAP126 gene Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear. Taurus_UMD|evm.model.AC_000160.1.68 P35720 C560_BOVIN 100.000 0.988235 1.00592 SDHC - Succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor - Bos taurus (Bovine) - SDHC gene Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Taurus_UMD|evm.model.AC_000160.1.69 P10522 MYP0_BOVIN 100.000 0.991968 1.00403 MPZ - Myelin protein P0 precursor - Bos taurus (Bovine) - MPZ gene Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. Taurus_UMD|evm.model.AC_000160.1.70 A8R4Q8 PC4L1_BOVIN 100.000 0.458333 2.08696 PCP4L1 - Purkinje cell protein 4-like protein 1 - Bos taurus (Bovine) - PCP4L1 gene Taurus_UMD|evm.model.AC_000160.1.71 P62045 NR1I3_PUSSI 84.483 0.994269 1.00287 NR1I3 - Nuclear receptor subfamily 1 group I member 3 - Pusa sibirica (Baikal seal) - NR1I3 gene Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity). Taurus_UMD|evm.model.AC_000160.1.72 A6QR22 TM40L_BOVIN 100.000 0.993528 1.00325 TOMM40L - Mitochondrial import receptor subunit TOM40B - Bos taurus (Bovine) - TOMM40L gene Potential channel-forming protein implicated in import of protein precursors into mitochondria. Taurus_UMD|evm.model.AC_000160.1.73 P81644 APOA2_BOVIN 100.000 0.980198 1.01 APOA2 - Apolipoprotein A-II precursor - Bos taurus (Bovine) - APOA2 gene May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. Has antimicrobial activity. Taurus_UMD|evm.model.AC_000160.1.74 P17694 NDUS2_BOVIN 100.000 0.77403 1.28078 NDUFS2 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor - Bos taurus (Bovine) - NDUFS2 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:10852722, PubMed:18721790). Essential for the catalytic activity and assembly of complex I (By similarity). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (By similarity). Plays an important role in carotid body sensing of hypoxia (By similarity). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity). Taurus_UMD|evm.model.AC_000160.1.75 Q5EA87 B4GT3_BOVIN 99.747 0.313741 3.17929 B4GALT3 - Beta-1,4-galactosyltransferase 3 - Bos taurus (Bovine) - B4GALT3 gene Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Taurus_UMD|evm.model.AC_000160.1.76 P56602 PPOX_BOVIN 100.000 0.979424 1.01887 PPOX - Protoporphyrinogen oxidase - Bos taurus (Bovine) - PPOX gene Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Taurus_UMD|evm.model.AC_000160.1.77 Q2KJ72 UBP21_BOVIN 99.823 0.789916 1.26372 USP21 - Ubiquitin carboxyl-terminal hydrolase 21 - Bos taurus (Bovine) - USP21 gene Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization. Taurus_UMD|evm.model.AC_000160.1.79 O75618 DEDD_HUMAN 98.742 0.99373 1.00314 DEDD - Death effector domain-containing protein - Homo sapiens (Human) - DEDD gene A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity). Taurus_UMD|evm.model.AC_000160.1.80 Q32LH4 NIT1_BOVIN 99.656 0.993151 0.890244 NIT1 - Deaminated glutathione amidase precursor - Bos taurus (Bovine) - NIT1 gene Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells. It is also a negative regulator of primary T-cells. Taurus_UMD|evm.model.AC_000160.1.81 A1A4P5 PFD2_BOVIN 100.000 0.987097 1.00649 PFDN2 - Prefoldin subunit 2 - Bos taurus (Bovine) - PFDN2 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Taurus_UMD|evm.model.AC_000160.1.82 Q8NEP7 KLDC9_HUMAN 87.679 0.991404 1 KLHDC9 - Kelch domain-containing protein 9 - Homo sapiens (Human) - KLHDC9 gene cyclin binding Taurus_UMD|evm.model.AC_000160.1.83 Q5E9Z9 NECT4_BOVIN 99.608 0.996086 1.00196 NECTIN4 - Nectin-4 precursor - Bos taurus (Bovine) - NECTIN4 gene Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Taurus_UMD|evm.model.AC_000160.1.84 Q7Z6I6 RHG30_HUMAN 80.325 0.998177 0.996367 ARHGAP30 - Rho GTPase-activating protein 30 - Homo sapiens (Human) - ARHGAP30 gene GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. Taurus_UMD|evm.model.AC_000160.1.85 Q6XBT4 USF1_BOVIN 100.000 0.993569 1.00323 USF1 - Upstream stimulatory factor 1 - Bos taurus (Bovine) - USF1 gene Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Taurus_UMD|evm.model.AC_000160.1.86 Q8NFU3 TSTD1_HUMAN 88.596 0.817518 1.1913 TSTD1 - Thiosulfate:glutathione sulfurtransferase - Homo sapiens (Human) - TSTD1 gene Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631). Taurus_UMD|evm.model.AC_000160.1.87 Q9XT56 JAM1_BOVIN 100.000 0.472817 2.03691 F11R - Junctional adhesion molecule A precursor - Bos taurus (Bovine) - F11R gene Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. Taurus_UMD|evm.model.AC_000160.1.88 Q8WWU7 ITLN2_HUMAN 86.207 0.531646 1.45846 ITLN2 - Intelectin-2 precursor - Homo sapiens (Human) - ITLN2 gene May play a role in the defense system against pathogens. Taurus_UMD|evm.model.AC_000160.1.89 Q8WWA0 ITLN1_HUMAN 85.560 0.899023 0.980831 ITLN1 - Intelectin-1 precursor - Homo sapiens (Human) - ITLN1 gene Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499). Taurus_UMD|evm.model.AC_000160.1.90 Q8WWA0 ITLN1_HUMAN 80.392 0.409836 0.389776 ITLN1 - Intelectin-1 precursor - Homo sapiens (Human) - ITLN1 gene Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499). Taurus_UMD|evm.model.AC_000160.1.91 Q8WWA0 ITLN1_HUMAN 89.313 0.305164 1.36102 ITLN1 - Intelectin-1 precursor - Homo sapiens (Human) - ITLN1 gene Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499). Taurus_UMD|evm.model.AC_000160.1.92 Q8VE62 PAIP1_MOUSE 91.275 0.763496 0.9725 Paip1 - Polyadenylate-binding protein-interacting protein 1 - Mus musculus (Mouse) - Paip1 gene Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). Taurus_UMD|evm.model.AC_000160.1.93 Q8VE62 PAIP1_MOUSE 83.673 0.205128 0.585 Paip1 - Polyadenylate-binding protein-interacting protein 1 - Mus musculus (Mouse) - Paip1 gene Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). Taurus_UMD|evm.model.AC_000160.1.94 Q9BZW8 CD244_HUMAN 55.759 0.99458 0.997297 CD244 - Natural killer cell receptor 2B4 precursor - Homo sapiens (Human) - CD244 gene Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:8376943, PubMed:11714776). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 (PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (PubMed:11917118). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity). Taurus_UMD|evm.model.AC_000160.1.95 Q9HBG7 LY9_HUMAN 61.496 0.650273 0.838168 LY9 - T-lymphocyte surface antigen Ly-9 precursor - Homo sapiens (Human) - LY9 gene Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.96 Q9HBG7 LY9_HUMAN 42.222 0.261128 0.514504 LY9 - T-lymphocyte surface antigen Ly-9 precursor - Homo sapiens (Human) - LY9 gene Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.97 Q2TBS4 PIFO_BOVIN 98.958 0.989637 1.00521 PIFO - Protein pitchfork - Bos taurus (Bovine) - PIFO gene During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000160.1.98 Q28042 OVGP1_BOVIN 90.457 0.700699 1.33147 OVGP1 - Oviduct-specific glycoprotein precursor - Bos taurus (Bovine) - OVGP1 gene Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. Taurus_UMD|evm.model.AC_000160.1.99 Q9NQ25 SLAF7_HUMAN 59.292 0.994065 1.00597 SLAMF7 - SLAM family member 7 precursor - Homo sapiens (Human) - SLAMF7 gene Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528). Taurus_UMD|evm.model.AC_000160.1.100 P09326 CD48_HUMAN 56.846 0.983333 0.987654 CD48 - CD48 antigen precursor - Homo sapiens (Human) - CD48 gene Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. Taurus_UMD|evm.model.AC_000160.1.101 Q95MM9 SLAF1_CANLF 69.096 0.9941 0.991228 SLAMF1 - Signaling lymphocytic activation molecule precursor - Canis lupus familiaris (Dog) - SLAMF1 gene Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1. Mediates IL-2-independent proliferation of activated T cells during immune responses and induces IFN-gamma production. Downstreaming signaling involves INPP5D/SHIP1, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production. Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells. Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells. Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells. May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells. May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion. In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type. In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A. In conjunction with SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response. Taurus_UMD|evm.model.AC_000160.1.102 Q9UIB8 SLAF5_HUMAN 69.565 0.960227 1.02029 CD84 - SLAM family member 5 precursor - Homo sapiens (Human) - CD84 gene Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity). Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed:29434592). Taurus_UMD|evm.model.AC_000160.1.103 Q96DU3 SLAF6_HUMAN 52.522 0.94051 1.06325 SLAMF6 - SLAM family member 6 precursor - Homo sapiens (Human) - SLAMF6 gene Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity). Taurus_UMD|evm.model.AC_000160.1.104 Q9ULK5 VANG2_HUMAN 99.808 0.996169 1.00192 VANGL2 - Vang-like protein 2 - Homo sapiens (Human) - VANGL2 gene Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). Taurus_UMD|evm.model.AC_000160.1.105 Q02575 HEN1_HUMAN 96.992 0.985075 1.00752 NHLH1 - Helix-loop-helix protein 1 - Homo sapiens (Human) - NHLH1 gene May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. Taurus_UMD|evm.model.AC_000160.1.106 Q92542 NICA_HUMAN 88.575 0.924282 1.08039 NCSTN - Nicastrin precursor - Homo sapiens (Human) - NCSTN gene Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Taurus_UMD|evm.model.AC_000160.1.107 Q27954 COPA_BOVIN 99.918 0.998367 1.00082 COPA - Coatomer subunit alpha - Bos taurus (Bovine) - COPA gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Taurus_UMD|evm.model.AC_000160.1.108 Q3SZD1 PEX19_BOVIN 100.000 0.993333 1.00334 PEX19 - Peroxisomal biogenesis factor 19 precursor - Bos taurus (Bovine) - PEX19 gene Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (By similarity). Taurus_UMD|evm.model.AC_000160.1.109 Q5TAQ9 DCAF8_HUMAN 97.822 0.996622 0.991625 DCAF8 - DDB1- and CUL4-associated factor 8 - Homo sapiens (Human) - DCAF8 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Taurus_UMD|evm.model.AC_000160.1.110 Q5U318 PEA15_RAT 100.000 0.984733 1.00769 Pea15 - Astrocytic phosphoprotein PEA-15 - Rattus norvegicus (Rat) - Pea15 gene Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). Taurus_UMD|evm.model.AC_000160.1.111 P19633 CASQ1_RAT 94.588 0.977273 0.975369 Casq1 - Calsequestrin-1 precursor - Rattus norvegicus (Rat) - Casq1 gene Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:8042990). Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction (By similarity). Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity). Taurus_UMD|evm.model.AC_000160.1.112 Q13733 AT1A4_HUMAN 86.505 0.99806 1.00194 ATP1A4 - Sodium/potassium-transporting ATPase subunit alpha-4 - Homo sapiens (Human) - ATP1A4 gene This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility. Taurus_UMD|evm.model.AC_000160.1.113 A2VDL6 AT1A2_BOVIN 100.000 0.998041 1.00098 ATP1A2 - Sodium/potassium-transporting ATPase subunit alpha-2 precursor - Bos taurus (Bovine) - ATP1A2 gene This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients (By similarity). Taurus_UMD|evm.model.AC_000160.1.114 Q969P0 IGSF8_HUMAN 92.061 0.967267 0.996737 IGSF8 - Immunoglobulin superfamily member 8 precursor - Homo sapiens (Human) - IGSF8 gene May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. Taurus_UMD|evm.model.AC_000160.1.115 Q63511 KCNJ9_RAT 96.049 0.995074 1.03308 Kcnj9 - G protein-activated inward rectifier potassium channel 3 - Rattus norvegicus (Rat) - Kcnj9 gene This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity). Taurus_UMD|evm.model.AC_000160.1.116 P78508 KCJ10_HUMAN 98.681 0.994737 1.00264 KCNJ10 - ATP-sensitive inward rectifier potassium channel 10 - Homo sapiens (Human) - KCNJ10 gene May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules. Taurus_UMD|evm.model.AC_000160.1.117 Q5EA10 PIGM_BOVIN 99.527 0.995283 1.00236 PIGM - GPI mannosyltransferase 1 - Bos taurus (Bovine) - PIGM gene Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity). Taurus_UMD|evm.model.AC_000160.1.118 Q96A28 SLAF9_HUMAN 69.349 0.896552 1.00346 SLAMF9 - SLAM family member 9 precursor - Homo sapiens (Human) - SLAMF9 gene May play a role in the immune response. Taurus_UMD|evm.model.AC_000160.1.119 Q9P2J2 TUTLA_HUMAN 89.992 0.998305 1.00085 IGSF9 - Protein turtle homolog A precursor - Homo sapiens (Human) - IGSF9 gene Functions in dendrite outgrowth and synapse maturation. Taurus_UMD|evm.model.AC_000160.1.120 Q5E9F5 TAGL2_BOVIN 100.000 0.99 1.00503 TAGLN2 - Transgelin-2 - Bos taurus (Bovine) - TAGLN2 gene Taurus_UMD|evm.model.AC_000160.1.121 Q9UL16 CFA45_HUMAN 90.381 0.996364 0.998185 CFAP45 - Cilia- and flagella-associated protein 45 - Homo sapiens (Human) - CFAP45 gene nucleoplasm, nucleus Taurus_UMD|evm.model.AC_000160.1.122 P0DPA3 SNH28_HUMAN 84.043 0.220379 1.79574 SNHG28 - Putative uncharacterized protein SNHG28 - Homo sapiens (Human) - SNHG28 gene RNA binding Taurus_UMD|evm.model.AC_000160.1.123 Q9P0V8 SLAF8_HUMAN 80.303 0.992424 0.926316 SLAMF8 - SLAM family member 8 precursor - Homo sapiens (Human) - SLAMF8 gene May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor. Taurus_UMD|evm.model.AC_000160.1.124 Q6DN72 FCRL6_HUMAN 63.607 0.801061 0.868664 FCRL6 - Fc receptor-like protein 6 precursor - Homo sapiens (Human) - FCRL6 gene Acts as a MHC class II receptor (PubMed:20519654). When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells (PubMed:17213291, PubMed:18991291). Does not act as an Fc receptor (PubMed:18991291). Taurus_UMD|evm.model.AC_000160.1.125 Q6NT99 DUS23_MOUSE 96.000 0.986755 1.00667 Dusp23 - Dual specificity protein phosphatase 23 - Mus musculus (Mouse) - Dusp23 gene Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). Taurus_UMD|evm.model.AC_000160.1.126 P02741 CRP_HUMAN 70.089 0.991111 1.00446 CRP - C-reactive protein precursor - Homo sapiens (Human) - CRP gene Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Taurus_UMD|evm.model.AC_000160.1.127 Q3T004 SAMP_BOVIN 100.000 0.991111 1.00446 APCS - Serum amyloid P-component precursor - Bos taurus (Bovine) - APCS gene extracellular space, complement component C1q complex binding, low-density lipoprotein particle binding, complement activation, classical pathway, innate immune response, negative regulation by host of viral process Taurus_UMD|evm.model.AC_000160.1.128 Q99728 BARD1_HUMAN 82.353 0.967213 0.157014 BARD1 - BRCA1-associated RING domain protein 1 - Homo sapiens (Human) - BARD1 gene E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. Taurus_UMD|evm.model.AC_000160.1.129 P0C629 O10J4_HUMAN 90.857 0.988636 0.565916 OR10J4 - Olfactory receptor 10J4 - Homo sapiens (Human) - OR10J4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000160.1.130 P30954 O10J1_HUMAN 83.516 0.708661 0.396875 OR10J1 - Olfactory receptor 10J1 - Homo sapiens (Human) - OR10J1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000160.1.131 Q5JRS4 O10J3_HUMAN 90.541 0.825843 0.541033 OR10J3 - Olfactory receptor 10J3 - Homo sapiens (Human) - OR10J3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000160.1.132 P12319 FCERA_HUMAN 60.784 0.97318 1.01556 FCER1A - High affinity immunoglobulin epsilon receptor subunit alpha precursor - Homo sapiens (Human) - FCER1A gene Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. Taurus_UMD|evm.model.AC_000160.1.133 Q3T166 MPTX_BOVIN 100.000 0.990826 1.00461 MPTX - Mucosal pentraxin precursor - Bos taurus (Bovine) - MPTX gene extracellular space, complement component C1q complex binding, low-density lipoprotein particle binding, complement activation, classical pathway, innate immune response, negative regulation by host of viral process Taurus_UMD|evm.model.AC_000160.1.134 P52301 RAN_XENLA 74.737 0.851852 0.5 ran - GTP-binding nuclear protein Ran - Xenopus laevis (African clawed frog) - ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:8413630). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446). Required for normal progress through mitosis (By similarity). In concert with nemp1a/b, required for proper eye development (PubMed:25946333). Taurus_UMD|evm.model.AC_000160.1.135 Q9GLX0 ACKR1_BOVIN 99.697 0.993958 1.00303 ACKR1 - Atypical chemokine receptor 1 - Bos taurus (Bovine) - ACKR1 gene Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity). Taurus_UMD|evm.model.AC_000160.1.136 Q8N126 CADM3_HUMAN 95.729 0.994962 0.997487 CADM3 - Cell adhesion molecule 3 precursor - Homo sapiens (Human) - CADM3 gene Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity). Taurus_UMD|evm.model.AC_000160.1.138 P0DOV2 IFI4_MOUSE 58.824 0.388889 0.843296 Ifi204 - Interferon-activable protein 204 - Mus musculus (Mouse) - Ifi204 gene Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation. Taurus_UMD|evm.model.AC_000160.1.140 Q96KK4 O10C1_HUMAN 47.195 0.942857 1.00962 OR10C1 - Olfactory receptor 10C1 - Homo sapiens (Human) - OR10C1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000160.1.141 Q8NGY3 OR6K3_HUMAN 80.906 0.971609 0.957704 OR6K3 - Olfactory receptor 6K3 - Homo sapiens (Human) - OR6K3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000160.1.142 Q8NGY2 OR6K2_HUMAN 76.129 0.916667 0.518519 OR6K2 - Olfactory receptor 6K2 - Homo sapiens (Human) - OR6K2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000160.1.143 P02549 SPTA1_HUMAN 74.689 0.998718 0.967755 SPTA1 - Spectrin alpha chain, erythrocytic 1 - Homo sapiens (Human) - SPTA1 gene Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Taurus_UMD|evm.model.AC_000160.1.144 Q8NGY0 O10X1_HUMAN 79.641 0.927374 0.54908 OR10X1 - Olfactory receptor 10X1 - Homo sapiens (Human) - OR10X1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000160.1.145 Q8NGY0 O10X1_HUMAN 81.579 0.946429 0.858896 OR10X1 - Olfactory receptor 10X1 - Homo sapiens (Human) - OR10X1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000160.1.146 Q71U00 SKP1_XENLA 99.387 0.987805 1.00613 skp1 - S-phase kinase-associated protein 1 - Xenopus laevis (African clawed frog) - skp1 gene Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). Taurus_UMD|evm.model.AC_000160.1.147 Q9XS72 CD1A_PIG 71.161 0.647202 1.21239 CD1A - T-cell surface glycoprotein CD1a precursor - Sus scrofa (Pig) - CD1A gene Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. Taurus_UMD|evm.model.AC_000160.1.148 Q8NGX5 O10K1_HUMAN 83.529 0.992188 0.817891 OR10K1 - Olfactory receptor 10K1 - Homo sapiens (Human) - OR10K1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000160.1.149 Q8NGX3 O10T2_HUMAN 95.918 0.986486 0.471338 OR10T2 - Olfactory receptor 10T2 - Homo sapiens (Human) - OR10T2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000160.1.150 P15812 CD1E_HUMAN 68.063 0.964377 1.01289 CD1E - T-cell surface glycoprotein CD1e, membrane-associated precursor - Homo sapiens (Human) - CD1E gene T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active. Taurus_UMD|evm.model.AC_000160.1.151 P80943 CD1B3_SHEEP 91.282 0.337391 2.47845 T-cell surface glycoprotein CD1b-3 - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000160.1.152 Q29422 CD1B2_SHEEP 91.209 0.353247 2.31231 T-cell surface glycoprotein CD1b-2 precursor - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000160.1.153 P68105 EF1A1_RABIT 97.078 0.993528 0.668831 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000160.1.154 P68105 EF1A1_RABIT 95.935 0.983871 0.268398 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000160.1.155 Q29422 CD1B2_SHEEP 87.912 0.797357 0.681682 T-cell surface glycoprotein CD1b-2 precursor - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000160.1.156 Q9XS72 CD1A_PIG 70.159 0.831551 1.10324 CD1A - T-cell surface glycoprotein CD1a precursor - Sus scrofa (Pig) - CD1A gene Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. Taurus_UMD|evm.model.AC_000160.1.157 O62848 CD1D_SHEEP 86.513 0.875723 1.03284 CD1D - Antigen-presenting glycoprotein CD1d precursor - Ovis aries (Sheep) - CD1D gene Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells. Taurus_UMD|evm.model.AC_000160.1.158 O62848 CD1D_SHEEP 85.987 0.752404 1.24179 CD1D - Antigen-presenting glycoprotein CD1d precursor - Ovis aries (Sheep) - CD1D gene Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells. Taurus_UMD|evm.model.AC_000160.1.159 O62848 CD1D_SHEEP 89.490 0.752404 1.24179 CD1D - Antigen-presenting glycoprotein CD1d precursor - Ovis aries (Sheep) - CD1D gene Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells. Taurus_UMD|evm.model.AC_000160.1.160 O62848 CD1D_SHEEP 86.513 0.89911 1.00597 CD1D - Antigen-presenting glycoprotein CD1d precursor - Ovis aries (Sheep) - CD1D gene Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells. Taurus_UMD|evm.model.AC_000160.1.161 Q29444 MANBA_BOVIN 99.502 0.990099 0.229807 MANBA - Beta-mannosidase precursor - Bos taurus (Bovine) - MANBA gene Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides. Taurus_UMD|evm.model.AC_000160.1.162 Q96J84 KIRR1_HUMAN 97.625 0.997365 1.00264 KIRREL1 - Kin of IRRE-like protein 1 precursor - Homo sapiens (Human) - KIRREL1 gene Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). Taurus_UMD|evm.model.AC_000160.1.163 O43866 CD5L_HUMAN 67.619 0.209677 1.42939 CD5L - CD5 antigen-like precursor - Homo sapiens (Human) - CD5L gene Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983). Taurus_UMD|evm.model.AC_000160.1.164 Q60997 DMBT1_MOUSE 51.376 0.120413 0.418225 Dmbt1 - Deleted in malignant brain tumors 1 protein precursor - Mus musculus (Mouse) - Dmbt1 gene May play roles in mucosal defense system and cellular immune defense. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. May function as a binding protein in saliva for the regulation of taste sensation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract (By similarity). Required for terminal differentiation of columnar epithelial cells during early embryogenesis. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. Taurus_UMD|evm.model.AC_000160.1.165 Q96LA6 FCRL1_HUMAN 64.232 0.994975 0.927739 FCRL1 - Fc receptor-like protein 1 precursor - Homo sapiens (Human) - FCRL1 gene May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. Taurus_UMD|evm.model.AC_000160.1.166 Q96P31 FCRL3_HUMAN 60.602 0.881971 1.05041 FCRL3 - Fc receptor-like protein 3 precursor - Homo sapiens (Human) - FCRL3 gene Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275). Taurus_UMD|evm.model.AC_000160.1.167 Q96PJ5 FCRL4_HUMAN 59.921 0.938086 1.03495 FCRL4 - Fc receptor-like protein 4 precursor - Homo sapiens (Human) - FCRL4 gene May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response. Taurus_UMD|evm.model.AC_000160.1.168 Q96RD9 FCRL5_HUMAN 55.344 0.919158 0.924258 FCRL5 - Fc receptor-like protein 5 precursor - Homo sapiens (Human) - FCRL5 gene May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. Taurus_UMD|evm.model.AC_000160.1.169 Q96RD9 FCRL5_HUMAN 69.565 0.514124 0.181167 FCRL5 - Fc receptor-like protein 5 precursor - Homo sapiens (Human) - FCRL5 gene May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. Taurus_UMD|evm.model.AC_000160.1.170 Q9HBG7 LY9_HUMAN 29.730 0.382514 0.558779 LY9 - T-lymphocyte surface antigen Ly-9 precursor - Homo sapiens (Human) - LY9 gene Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.171 Q01965 LY9_MOUSE 27.143 0.765537 0.541284 Ly9 - T-lymphocyte surface antigen Ly-9 precursor - Mus musculus (Mouse) - Ly9 gene Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:19648922). May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A. Promotes recruitment of RORC to the IL-17 promoter (By similarity). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells (PubMed:23914190). May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (PubMed:23225888). Can promote natural killer (NK) cell activation (PubMed:19648922). Taurus_UMD|evm.model.AC_000160.1.172 Q4R4Y9 IF4A2_MACFA 92.308 0.296512 0.421569 EIF4A2 - Eukaryotic initiation factor 4A-II - Macaca fascicularis (Crab-eating macaque) - EIF4A2 gene ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). Taurus_UMD|evm.model.AC_000160.1.175 Q9D780 SLAF9_MOUSE 29.032 0.327027 1.29825 Slamf9 - SLAM family member 9 precursor - Mus musculus (Mouse) - Slamf9 gene May play a role in the immune response. Taurus_UMD|evm.model.AC_000160.1.176 P18181 CD48_MOUSE 30.189 0.576471 1.0625 Cd48 - CD48 antigen precursor - Mus musculus (Mouse) - Cd48 gene Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. Taurus_UMD|evm.model.AC_000160.1.180 P50397 GDIB_BOVIN 92.975 0.991736 0.54382 GDI2 - Rab GDP dissociation inhibitor beta - Bos taurus (Bovine) - GDI2 gene Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Taurus_UMD|evm.model.AC_000160.1.182 A1YF15 ETV3_GORGO 91.797 0.996078 0.996094 ETV3 - ETS translocation variant 3 - Gorilla gorilla gorilla (Western lowland gorilla) - ETV3 gene Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity (By similarity). Taurus_UMD|evm.model.AC_000160.1.184 Q8R4Z4 ETV3_MOUSE 89.831 0.325905 0.699805 Etv3 - ETS translocation variant 3 - Mus musculus (Mouse) - Etv3 gene Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. Taurus_UMD|evm.model.AC_000160.1.185 O15085 ARHGB_HUMAN 85.980 0.998711 1.01905 ARHGEF11 - Rho guanine nucleotide exchange factor 11 - Homo sapiens (Human) - ARHGEF11 gene May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. Taurus_UMD|evm.model.AC_000160.1.186 Q8N4P6 LRC71_HUMAN 84.119 0.991304 1.02862 LRRC71 - Leucine-rich repeat-containing protein 71 - Homo sapiens (Human) - LRRC71 gene Taurus_UMD|evm.model.AC_000160.1.187 Q5VY43 PEAR1_HUMAN 88.074 0.981748 1.00386 PEAR1 - Platelet endothelial aggregation receptor 1 precursor - Homo sapiens (Human) - PEAR1 gene When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells. Taurus_UMD|evm.model.AC_000160.1.188 P04629 NTRK1_HUMAN 92.714 0.997487 1 NTRK1 - High affinity nerve growth factor receptor precursor - Homo sapiens (Human) - NTRK1 gene Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:22649032, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Taurus_UMD|evm.model.AC_000160.1.189 P14616 INSRR_HUMAN 93.159 0.998464 1.00386 INSRR - Insulin receptor-related protein precursor - Homo sapiens (Human) - INSRR gene Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Taurus_UMD|evm.model.AC_000160.1.190 Q9NP31 SH22A_HUMAN 73.508 0.995227 1.07712 SH2D2A - SH2 domain-containing protein 2A - Homo sapiens (Human) - SH2D2A gene Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. Taurus_UMD|evm.model.AC_000160.1.191 Q92733 PRCC_HUMAN 97.358 0.995943 1.00407 PRCC - Proline-rich protein PRCC - Homo sapiens (Human) - PRCC gene May regulate cell cycle progression through interaction with MAD2L2. Taurus_UMD|evm.model.AC_000160.1.192 Q9XSK7 HDGF_BOVIN 100.000 0.496842 1.98745 HDGF - Hepatoma-derived growth factor - Bos taurus (Bovine) - HDGF gene Acts as a transcriptional repressor (By similarity). Has mitogenic activity for fibroblasts (By similarity). Heparin-binding protein (By similarity). Taurus_UMD|evm.model.AC_000160.1.193 Q5E9V4 RRNAD_BOVIN 99.789 0.995798 1.00211 RRNAD1 - Protein RRNAD1 - Bos taurus (Bovine) - RRNAD1 gene Taurus_UMD|evm.model.AC_000160.1.194 Q2YDK1 I20L2_BOVIN 100.000 0.994286 1.00287 ISG20L2 - Interferon-stimulated 20 kDa exonuclease-like 2 - Bos taurus (Bovine) - ISG20L2 gene 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group. Taurus_UMD|evm.model.AC_000160.1.195 Q5PXY7 RABP2_BOVIN 99.275 0.985612 1.00725 CRABP2 - Cellular retinoic acid-binding protein 2 - Bos taurus (Bovine) - CRABP2 gene Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors (By similarity). Taurus_UMD|evm.model.AC_000160.1.196 P48681 NEST_HUMAN 63.925 0.415249 0.979025 NES - Nestin - Homo sapiens (Human) - NES gene Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.197 Q28062 PGCB_BOVIN 99.671 0.997809 1.0011 BCAN - Brevican core protein precursor - Bos taurus (Bovine) - BCAN gene May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Taurus_UMD|evm.model.AC_000160.1.198 Q9GZV7 HPLN2_HUMAN 92.059 0.994135 1.00294 HAPLN2 - Hyaluronan and proteoglycan link protein 2 precursor - Homo sapiens (Human) - HAPLN2 gene Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity). Taurus_UMD|evm.model.AC_000160.1.199 Q2KJE1 GPTC4_BOVIN 100.000 0.914607 1.09069 GPATCH4 - G patch domain-containing protein 4 - Bos taurus (Bovine) - GPATCH4 gene Taurus_UMD|evm.model.AC_000160.1.200 Q6QRN6 NNRE_BOVIN 100.000 0.99308 1.00347 NAXE - NAD(P)H-hydrate epimerase precursor - Bos taurus (Bovine) - NAXE gene Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (By similarity). Taurus_UMD|evm.model.AC_000160.1.201 A2A3L6 TTC24_HUMAN 71.993 0.99631 0.931271 TTC24 - Tetratricopeptide repeat protein 24 - Homo sapiens (Human) - TTC24 gene Taurus_UMD|evm.model.AC_000160.1.202 Q86VI3 IQGA3_HUMAN 89.358 0.998762 0.990803 IQGAP3 - Ras GTPase-activating-like protein IQGAP3 - Homo sapiens (Human) - IQGAP3 gene cytoplasm, cytosol, actin filament binding, calmodulin binding, GTPase activator activity, myosin VI light chain binding, regulation of actin cytoskeleton organization Taurus_UMD|evm.model.AC_000160.1.203 Q56K03 RL27A_BOVIN 98.649 0.986577 1.00676 RPL27A - 60S ribosomal protein L27a - Bos taurus (Bovine) - RPL27A gene cytosolic large ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000160.1.205 O89038 MEF2D_RAT 94.477 0.996063 1.00197 Mef2d - Myocyte-specific enhancer factor 2D - Rattus norvegicus (Rat) - Mef2d gene Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). Taurus_UMD|evm.model.AC_000160.1.206 Q95M77 RHBG_BOVIN 100.000 0.995614 1.0022 RHBG - Ammonium transporter Rh type B - Bos taurus (Bovine) - RHBG gene Functions as a specific ammonium transporter. Taurus_UMD|evm.model.AC_000160.1.207 Q3T016 TSACC_BOVIN 99.200 0.953846 1.04 TSACC - TSSK6-activating co-chaperone protein - Bos taurus (Bovine) - TSACC gene Co-chaperone that facilitates HSP-mediated activation of TSSK6. Taurus_UMD|evm.model.AC_000160.1.208 Q3T0K2 TCPG_BOVIN 100.000 0.996337 1.00183 CCT3 - T-complex protein 1 subunit gamma - Bos taurus (Bovine) - CCT3 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Taurus_UMD|evm.model.AC_000160.1.209 Q0P5L7 GLMP_BOVIN 100.000 0.995062 1.00248 GLMP - Glycosylated lysosomal membrane protein precursor - Bos taurus (Bovine) - GLMP gene Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization. Taurus_UMD|evm.model.AC_000160.1.210 Q5E9U3 TMM79_BOVIN 100.000 0.994949 1.00253 TMEM79 - Transmembrane protein 79 - Bos taurus (Bovine) - TMEM79 gene Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity). Taurus_UMD|evm.model.AC_000160.1.211 Q9UPR3 SMG5_HUMAN 96.161 0.998033 1.00098 SMG5 - Protein SMG5 - Homo sapiens (Human) - SMG5 gene Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. Taurus_UMD|evm.model.AC_000160.1.213 Q6TCH4 PAQR6_HUMAN 91.515 0.713666 1.34012 PAQR6 - Membrane progestin receptor delta - Homo sapiens (Human) - PAQR6 gene Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23763432, PubMed:23161870). Taurus_UMD|evm.model.AC_000160.1.214 P02820 OSTCN_BOVIN 100.000 0.980198 1.01 BGLAP - Osteocalcin precursor - Bos taurus (Bovine) - BGLAP gene Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Taurus_UMD|evm.model.AC_000160.1.215 Q2T9N4 PMF1_BOVIN 84.390 0.988764 0.868293 PMF1 - Polyamine-modulated factor 1 - Bos taurus (Bovine) - PMF1 gene Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT (By similarity). Taurus_UMD|evm.model.AC_000160.1.216 Q5RD67 S2544_PONAB 99.045 0.993651 1.00318 SLC25A44 - Solute carrier family 25 member 44 - Pongo abelii (Sumatran orangutan) - SLC25A44 gene Mitochondrial solute transporter which transports branched-chain amino acid (BCAA; valine, leucine and isoleucine) into mitochondria in brown adipose tissue (BAT). BAT is involved in BCAA catabolism and actively utilizes BCAA in the mitochondria for thermogenesis. Taurus_UMD|evm.model.AC_000160.1.217 Q5EA85 SEM4A_BOVIN 99.869 0.997379 1.00131 SEMA4A - Semaphorin-4A precursor - Bos taurus (Bovine) - SEMA4A gene Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity). Regulates glutamatergic and GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (By similarity). Promotes phosphorylation of TIMD2 (By similarity). Inhibits angiogenesis (By similarity). Promotes axon growth cone collapse (By similarity). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity). Taurus_UMD|evm.model.AC_000160.1.218 Q3ZD69 LMNA_PIG 97.594 0.996992 1.00151 LMNA - Prelamin-A/C precursor - Sus scrofa (Pig) - LMNA gene Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (By similarity). Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone. Required for cardiac homeostasis. Taurus_UMD|evm.model.AC_000160.1.219 A1L020 MEX3A_HUMAN 98.643 0.98 0.865385 MEX3A - RNA-binding protein MEX3A - Homo sapiens (Human) - MEX3A gene RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. Taurus_UMD|evm.model.AC_000160.1.220 Q58DW6 RAB25_BOVIN 100.000 0.990654 1.00469 RAB25 - Ras-related protein Rab-25 precursor - Bos taurus (Bovine) - RAB25 gene Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity). Taurus_UMD|evm.model.AC_000160.1.221 Q9Y2Q5 LTOR2_HUMAN 100.000 0.984127 1.008 LAMTOR2 - Ragulator complex protein LAMTOR2 - Homo sapiens (Human) - LAMTOR2 gene As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. Taurus_UMD|evm.model.AC_000160.1.222 Q9NRR5 UBQL4_HUMAN 96.173 0.996678 1.00166 UBQLN4 - Ubiquilin-4 - Homo sapiens (Human) - UBQLN4 gene Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). Taurus_UMD|evm.model.AC_000160.1.223 Q6ZN17 LN28B_HUMAN 75.000 0.44 0.5 LIN28B - Protein lin-28 homolog B - Homo sapiens (Human) - LIN28B gene Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. Taurus_UMD|evm.model.AC_000160.1.225 B2DCZ9 ARHG2_PIG 96.778 0.684511 1.45786 ARHGEF2 - Rho guanine nucleotide exchange factor 2 - Sus scrofa (Pig) - ARHGEF2 gene Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability. Involved in neuronal progenitor cell division and differentiation. Involved in the migration of precerebellar neurons. Taurus_UMD|evm.model.AC_000160.1.228 Q8TDU9 RL3R2_HUMAN 87.768 0.993884 0.874332 RXFP4 - Relaxin-3 receptor 2 - Homo sapiens (Human) - RXFP4 gene High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation. Taurus_UMD|evm.model.AC_000160.1.229 Q92963 RIT1_HUMAN 99.087 0.265931 3.72603 RIT1 - GTP-binding protein Rit1 - Homo sapiens (Human) - RIT1 gene Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. Taurus_UMD|evm.model.AC_000160.1.230 Q9BT88 SYT11_HUMAN 96.984 0.99536 1 SYT11 - Synaptotagmin-11 - Homo sapiens (Human) - SYT11 gene Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822). Taurus_UMD|evm.model.AC_000160.1.231 Q3T8J9 GON4L_HUMAN 77.143 0.564236 0.257028 GON4L - GON-4-like protein - Homo sapiens (Human) - GON4L gene Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis. Taurus_UMD|evm.model.AC_000160.1.232 Q3T8J9 GON4L_HUMAN 66.667 0.841463 0.109772 GON4L - GON-4-like protein - Homo sapiens (Human) - GON4L gene Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis. Taurus_UMD|evm.model.AC_000160.1.233 Q3T8J9 GON4L_HUMAN 82.429 0.951006 1.02008 GON4L - GON-4-like protein - Homo sapiens (Human) - GON4L gene Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis. Taurus_UMD|evm.model.AC_000160.1.234 A5D9D4 MSTO1_BOVIN 100.000 0.99651 1.00175 MSTO1 - Protein misato homolog 1 - Bos taurus (Bovine) - MSTO1 gene Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation. Taurus_UMD|evm.model.AC_000160.1.235 P82922 RT29_BOVIN 100.000 0.569784 1.75063 DAP3 - 28S ribosomal protein S29, mitochondrial precursor - Bos taurus (Bovine) - DAP3 gene Involved in mediating interferon-gamma-induced cell death. Taurus_UMD|evm.model.AC_000160.1.236 Q9NR48 ASH1L_HUMAN 95.657 0.999326 0.99899 ASH1L - Histone-lysine N-methyltransferase ASH1L - Homo sapiens (Human) - ASH1L gene Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). Taurus_UMD|evm.model.AC_000160.1.237 Q9BVN2 RUSC1_HUMAN 87.969 0.997792 1.00443 RUSC1 - RUN and SH3 domain-containing protein 1 - Homo sapiens (Human) - RUSC1 gene Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway. Taurus_UMD|evm.model.AC_000160.1.238 Q8WMY2 FPPS_BOVIN 100.000 0.826291 1.2068 FDPS - Farnesyl pyrophosphate synthase - Bos taurus (Bovine) - FDPS gene Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity). Taurus_UMD|evm.model.AC_000160.1.239 P30613 KPYR_HUMAN 92.471 0.981025 0.918118 PKLR - Pyruvate kinase PKLR - Homo sapiens (Human) - PKLR gene Plays a key role in glycolysis. Taurus_UMD|evm.model.AC_000160.1.240 Q9P1Z3 HCN3_HUMAN 95.402 0.997449 1.01292 HCN3 - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 - Homo sapiens (Human) - HCN3 gene Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions. Taurus_UMD|evm.model.AC_000160.1.241 P49760 CLK2_HUMAN 99.000 0.996008 1.00401 CLK2 - Dual specificity protein kinase CLK2 - Homo sapiens (Human) - CLK2 gene Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210). Taurus_UMD|evm.model.AC_000160.1.242 Q58DR5 SCAM3_BOVIN 99.424 0.994253 1.00288 SCAMP3 - Secretory carrier-associated membrane protein 3 - Bos taurus (Bovine) - SCAMP3 gene Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface (By similarity). Taurus_UMD|evm.model.AC_000160.1.243 P81408 F189B_HUMAN 95.659 0.99701 1.0015 FAM189B - Protein FAM189B - Homo sapiens (Human) - FAM189B gene WW domain binding Taurus_UMD|evm.model.AC_000160.1.244 Q2KHZ8 GLCM_BOVIN 99.813 0.996276 1.00187 GBA - Lysosomal acid glucosylceramidase precursor - Bos taurus (Bovine) - GBA gene Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction. Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide. Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol. Taurus_UMD|evm.model.AC_000160.1.245 Q2TBS1 MTX1_BOVIN 99.685 0.678112 1.47003 MTX1 - Metaxin-1 - Bos taurus (Bovine) - MTX1 gene Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity). Taurus_UMD|evm.model.AC_000160.1.246 P49746 TSP3_HUMAN 97.594 0.99791 1.00105 THBS3 - Thrombospondin-3 precursor - Homo sapiens (Human) - THBS3 gene Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. Taurus_UMD|evm.model.AC_000160.1.247 Q8WML4 MUC1_BOVIN 99.004 0.781591 1.10517 MUC1 - Mucin-1 precursor - Bos taurus (Bovine) - MUC1 gene The alpha subunit has cell adhesive properties. May provide a protective layer on epithelial cells against bacterial and enzyme attack (By similarity). Taurus_UMD|evm.model.AC_000160.1.248 Q7Z4K8 TRI46_HUMAN 98.551 0.940447 1.06192 TRIM46 - Tripartite motif-containing protein 46 - Homo sapiens (Human) - TRIM46 gene Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration. Taurus_UMD|evm.model.AC_000160.1.249 A6QQ59 KTAP2_BOVIN 100.000 0.978261 1.01471 KRTCAP2 - Keratinocyte-associated protein 2 - Bos taurus (Bovine) - KRTCAP2 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. Taurus_UMD|evm.model.AC_000160.1.250 Q3ZC71 DPM3_BOVIN 100.000 0.978495 1.01087 DPM3 - Dolichol-phosphate mannosyltransferase subunit 3 - Bos taurus (Bovine) - DPM3 gene Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER. Taurus_UMD|evm.model.AC_000160.1.251 Q3ZC64 EFNA1_BOVIN 100.000 0.503704 1.97561 EFNA1 - Ephrin-A1 precursor - Bos taurus (Bovine) - EFNA1 gene Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis (By similarity). Taurus_UMD|evm.model.AC_000160.1.252 P52797 EFNA3_HUMAN 98.319 0.991632 1.0042 EFNA3 - Ephrin-A3 precursor - Homo sapiens (Human) - EFNA3 gene Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). Taurus_UMD|evm.model.AC_000160.1.253 P52798 EFNA4_HUMAN 79.787 0.912195 1.0199 EFNA4 - Ephrin-A4 precursor - Homo sapiens (Human) - EFNA4 gene Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. Taurus_UMD|evm.model.AC_000160.1.254 Q13444 ADA15_HUMAN 82.726 0.980392 1.00463 ADAM15 - Disintegrin and metalloproteinase domain-containing protein 15 precursor - Homo sapiens (Human) - ADAM15 gene Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. Taurus_UMD|evm.model.AC_000160.1.255 Q5T197 DCST1_HUMAN 82.128 0.995745 0.998584 DCST1 - E3 ubiquitin-protein ligase DCST1 - Homo sapiens (Human) - DCST1 gene E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. Taurus_UMD|evm.model.AC_000160.1.256 Q5T1A1 DCST2_HUMAN 83.776 0.995816 0.927555 DCST2 - DC-STAMP domain-containing protein 2 - Homo sapiens (Human) - DCST2 gene Taurus_UMD|evm.model.AC_000160.1.257 O15156 ZBT7B_HUMAN 92.620 0.816109 1.22078 ZBTB7B - Zinc finger and BTB domain-containing protein 7B - Homo sapiens (Human) - ZBTB7B gene Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity). Taurus_UMD|evm.model.AC_000160.1.258 Q9Y5L5 LENEP_HUMAN 88.525 0.454545 2.16393 LENEP - Lens epithelial cell protein LEP503 - Homo sapiens (Human) - LENEP gene May play a role in lens epithelial cell differentiation. Taurus_UMD|evm.model.AC_000160.1.259 Q8NFF5 FAD1_HUMAN 91.111 0.867955 1.05792 FLAD1 - FAD synthase precursor - Homo sapiens (Human) - FLAD1 gene Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. Taurus_UMD|evm.model.AC_000160.1.260 Q0IIE2 SHC1_BOVIN 100.000 0.808219 1.23467 SHC1 - SHC-transforming protein 1 - Bos taurus (Bovine) - SHC1 gene Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Taurus_UMD|evm.model.AC_000160.1.262 Q9BRQ0 PYGO2_HUMAN 98.030 0.995074 1 PYGO2 - Pygopus homolog 2 - Homo sapiens (Human) - PYGO2 gene Involved in signal transduction through the Wnt pathway. Taurus_UMD|evm.model.AC_000160.1.263 A6QLY7 PBIP1_BOVIN 99.862 0.997249 1 PBXIP1 - Pre-B-cell leukemia transcription factor-interacting protein 1 - Bos taurus (Bovine) - PBXIP1 gene Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (By similarity). Taurus_UMD|evm.model.AC_000160.1.264 Q5T197 DCST1_HUMAN 94.030 0.767442 0.121813 DCST1 - E3 ubiquitin-protein ligase DCST1 - Homo sapiens (Human) - DCST1 gene E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling. Taurus_UMD|evm.model.AC_000160.1.265 Q2KIU2 PMVK_BOVIN 99.479 0.989637 1.00521 PMVK - Phosphomevalonate kinase - Bos taurus (Bovine) - PMVK gene Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites. Taurus_UMD|evm.model.AC_000160.1.266 P58392 KCNN3_PIG 98.590 0.984637 0.98895 KCNN3 - Small conductance calcium-activated potassium channel protein 3 - Sus scrofa (Pig) - KCNN3 gene Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity). Taurus_UMD|evm.model.AC_000160.1.267 P55265 DSRAD_HUMAN 79.462 0.998261 0.93801 ADAR - Double-stranded RNA-specific adenosine deaminase - Homo sapiens (Human) - ADAR gene Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:7972084, PubMed:7565688, PubMed:12618436). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. Taurus_UMD|evm.model.AC_000160.1.268 P17787 ACHB2_HUMAN 95.817 0.996016 1 CHRNB2 - Neuronal acetylcholine receptor subunit beta-2 precursor - Homo sapiens (Human) - CHRNB2 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. Taurus_UMD|evm.model.AC_000160.1.269 Q7Z7E8 UB2Q1_HUMAN 100.000 0.995272 1.00237 UBE2Q1 - Ubiquitin-conjugating enzyme E2 Q1 - Homo sapiens (Human) - UBE2Q1 gene Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:22496338). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity). Taurus_UMD|evm.model.AC_000160.1.270 Q5VZ19 TDR10_HUMAN 74.164 0.910405 0.945355 TDRD10 - Tudor domain-containing protein 10 - Homo sapiens (Human) - TDRD10 gene Taurus_UMD|evm.model.AC_000160.1.271 Q5VZ18 SHE_HUMAN 88.780 0.969407 1.05657 SHE - SH2 domain-containing adapter protein E - Homo sapiens (Human) - SHE gene phosphotyrosine residue binding Taurus_UMD|evm.model.AC_000160.1.272 O18796 IL6RA_PIG 79.915 0.995699 0.995717 IL6R - Interleukin-6 receptor subunit alpha precursor - Sus scrofa (Pig) - IL6R gene Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. Taurus_UMD|evm.model.AC_000160.1.273 P98198 AT8B2_HUMAN 97.981 0.966558 1.01406 ATP8B2 - Phospholipid-transporting ATPase ID - Homo sapiens (Human) - ATP8B2 gene Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. May contribute to the maintenance of membrane lipid asymmetry. Taurus_UMD|evm.model.AC_000160.1.274 Q96PS8 AQP10_HUMAN 70.608 0.989209 0.923588 AQP10 - Aquaporin-10 - Homo sapiens (Human) - AQP10 gene Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH (PubMed:12084581, PubMed:21733844, PubMed:23382902, PubMed:30420639). The channel is permeable to glycerol, especially when the cytosolic pH is acidified (PubMed:21733844, PubMed:30420639). Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation (PubMed:23382902). May contribute to water transport in the intestine (Probable). Taurus_UMD|evm.model.AC_000160.1.275 Q2KIE2 HAX1_BOVIN 99.283 0.985816 1.01075 HAX1 - HCLS1-associated protein X-1 - Bos taurus (Bovine) - HAX1 gene Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. Taurus_UMD|evm.model.AC_000160.1.276 Q14157 UBP2L_HUMAN 98.804 0.998162 1.00092 UBAP2L - Ubiquitin-associated protein 2-like - Homo sapiens (Human) - UBAP2L gene Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs). Required for efficient formation of stress granules (PubMed:29395067). Taurus_UMD|evm.model.AC_000160.1.277 Q5E943 CA043_BOVIN 99.605 0.992126 1.00395 Protein C1orf43 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000160.1.278 Q32L75 CA189_BOVIN 83.178 0.981481 1.06931 Uncharacterized protein C1orf189 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000160.1.279 Q5KR47 TPM3_BOVIN 87.676 0.992982 1.00352 TPM3 - Tropomyosin alpha-3 chain - Bos taurus (Bovine) - TPM3 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Taurus_UMD|evm.model.AC_000160.1.280 Q5VU65 P210L_HUMAN 89.978 0.983024 0.998411 NUP210L - Nuclear pore membrane glycoprotein 210-like precursor - Homo sapiens (Human) - NUP210L gene nuclear pore Taurus_UMD|evm.model.AC_000160.1.281 Q71TY3 RS27_RAT 100.000 0.976471 1.0119 Rps27 - 40S ribosomal protein S27 - Rattus norvegicus (Rat) - Rps27 gene Component of the small ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity). Taurus_UMD|evm.model.AC_000160.1.282 Q6Q311 RS25_SHEEP 100.000 0.984127 1.008 RPS25 - 40S ribosomal protein S25 - Ovis aries (Sheep) - RPS25 gene Taurus_UMD|evm.model.AC_000160.1.283 Q58DS5 RAB13_BOVIN 99.507 0.990196 1.00493 RAB13 - Ras-related protein Rab-13 precursor - Bos taurus (Bovine) - RAB13 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis (By similarity). Taurus_UMD|evm.model.AC_000160.1.284 O76095 JTB_HUMAN 89.726 0.986395 1.00685 JTB - Protein JTB precursor - Homo sapiens (Human) - JTB gene Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity). Taurus_UMD|evm.model.AC_000160.1.285 Q8TEY5 CR3L4_HUMAN 81.772 0.994924 0.997468 CREB3L4 - Cyclic AMP-responsive element-binding protein 3-like protein 4 - Homo sapiens (Human) - CREB3L4 gene Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). Taurus_UMD|evm.model.AC_000160.1.286 Q3SYU3 S39A1_BOVIN 100.000 0.993846 1.00309 SLC39A1 - Zinc transporter ZIP1 - Bos taurus (Bovine) - SLC39A1 gene Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body (By similarity). Taurus_UMD|evm.model.AC_000160.1.287 Q08E26 CRTC2_BOVIN 97.875 0.997171 1.0202 CRTC2 - CREB-regulated transcription coactivator 2 - Bos taurus (Bovine) - CRTC2 gene Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.289 O75064 DEN4B_HUMAN 100.000 0.821705 0.0862299 DENND4B - DENN domain-containing protein 4B - Homo sapiens (Human) - DENND4B gene Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Taurus_UMD|evm.model.AC_000160.1.290 O75064 DEN4B_HUMAN 93.241 0.99429 0.819519 DENND4B - DENN domain-containing protein 4B - Homo sapiens (Human) - DENND4B gene Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Taurus_UMD|evm.model.AC_000160.1.291 Q8WXI9 P66B_HUMAN 99.157 0.996627 1 GATAD2B - Transcriptional repressor p66-beta - Homo sapiens (Human) - GATAD2B gene Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development. Taurus_UMD|evm.model.AC_000160.1.292 Q2VWP9 PRTG_RAT 31.395 0.285444 0.44342 Prtg - Protogenin precursor - Rattus norvegicus (Rat) - Prtg gene May play a role in anteroposterior axis elongation. Taurus_UMD|evm.model.AC_000160.1.293 Q5K4L6 S27A3_HUMAN 88.654 0.963127 0.992679 SLC27A3 - Solute carrier family 27 member 3 - Homo sapiens (Human) - SLC27A3 gene Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (PubMed:23936004). Does not exhibit fatty acid transport activity (By similarity). Taurus_UMD|evm.model.AC_000160.1.294 Q68E01 INT3_HUMAN 99.137 0.998079 0.998082 INTS3 - Integrator complex subunit 3 - Homo sapiens (Human) - INTS3 gene Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). Taurus_UMD|evm.model.AC_000160.1.295 P16066 ANPRA_HUMAN 92.931 0.992488 1.00377 NPR1 - Atrial natriuretic peptide receptor 1 precursor - Homo sapiens (Human) - NPR1 gene Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. Taurus_UMD|evm.model.AC_000160.1.296 Q5RFJ1 ILF2_PONAB 100.000 0.994885 1.00256 ILF2 - Interleukin enhancer-binding factor 2 - Pongo abelii (Sumatran orangutan) - ILF2 gene Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity). Essential for the efficient reshuttling of ILF3 into the nucleus (By similarity). Taurus_UMD|evm.model.AC_000160.1.297 P60192 SNAPN_RAT 97.794 0.985401 1.00735 Snapin - SNARE-associated protein Snapin - Rattus norvegicus (Rat) - Snapin gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:10195194, PubMed:11283605). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity). Taurus_UMD|evm.model.AC_000160.1.298 P02639 S10A1_BOVIN 100.000 0.163386 5.40426 S100A1 - Protein S100-A1 - Bos taurus (Bovine) - S100A1 gene Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole. Taurus_UMD|evm.model.AC_000160.1.299 P79342 S10AD_BOVIN 100.000 0.668966 1.47959 S100A13 - Protein S100-A13 - Bos taurus (Bovine) - S100A13 gene Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity). Taurus_UMD|evm.model.AC_000160.1.300 Q3MHP3 S10AE_BOVIN 100.000 0.980952 1.00962 S100A14 - Protein S100-A14 - Bos taurus (Bovine) - S100A14 gene Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium (By similarity). Taurus_UMD|evm.model.AC_000160.1.301 Q0VCM0 S10AG_BOVIN 100.000 0.980769 1.00971 S100A16 - Protein S100-A16 - Bos taurus (Bovine) - S100A16 gene Calcium-binding protein. Binds one calcium ion per monomer (By similarity). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity). Taurus_UMD|evm.model.AC_000160.1.302 P10462 S10A2_BOVIN 100.000 0.979592 1.01031 S100A2 - Protein S100-A2 - Bos taurus (Bovine) - S100A2 gene May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth (By similarity). Taurus_UMD|evm.model.AC_000160.1.303 P33764 S10A3_HUMAN 67.327 0.98 0.990099 S100A3 - Protein S100-A3 - Homo sapiens (Human) - S100A3 gene Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation. Taurus_UMD|evm.model.AC_000160.1.304 P35466 S10A4_BOVIN 100.000 0.980392 1.0099 S100A4 - Protein S100-A4 - Bos taurus (Bovine) - S100A4 gene Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (By similarity). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity). Taurus_UMD|evm.model.AC_000160.1.305 P33763 S10A5_HUMAN 95.652 0.494565 2 S100A5 - Protein S100-A5 - Homo sapiens (Human) - S100A5 gene Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites. Taurus_UMD|evm.model.AC_000160.1.306 Q28050 S10A7_BOVIN 100.000 0.980392 1.0099 S100A7 - Protein S100-A7 - Bos taurus (Bovine) - S100A7 gene extracellular space, calcium ion binding, calcium-dependent protein binding Taurus_UMD|evm.model.AC_000160.1.307 P54762 EPHB1_HUMAN 83.333 0.0769231 0.369919 EPHB1 - Ephrin type-B receptor 1 precursor - Homo sapiens (Human) - EPHB1 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). Taurus_UMD|evm.model.AC_000160.1.308 Q28050 S10A7_BOVIN 91.089 0.462963 2.13861 S100A7 - Protein S100-A7 - Bos taurus (Bovine) - S100A7 gene extracellular space, calcium ion binding, calcium-dependent protein binding Taurus_UMD|evm.model.AC_000160.1.309 A7K6Y9 S115A_PONAB 86.111 0.981651 1.00926 S100A15A - Protein S100-A15A - Pongo abelii (Sumatran orangutan) - S100A15A gene Taurus_UMD|evm.model.AC_000160.1.310 P28782 S10A8_BOVIN 100.000 0.977778 1.01124 S100A8 - Protein S100-A8 - Bos taurus (Bovine) - S100A8 gene S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants (By similarity). The iNOS-S100A8/A9 transnitrosylase complex is proposed to direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as GAPDH, ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity (By similarity). Taurus_UMD|evm.model.AC_000160.1.311 P79105 S10AC_BOVIN 100.000 0.978495 1.01087 S100A12 - Protein S100-A12 - Bos taurus (Bovine) - S100A12 gene S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites (By similarity). Taurus_UMD|evm.model.AC_000160.1.312 P28783 S10A9_BOVIN 98.718 0.987261 1.00641 S100A9 - Protein S100-A9 - Bos taurus (Bovine) - S100A9 gene S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. The iNOS-S100A8/A9 transnitrosylase complex is proposed to direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as GAPDH, NXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif. Taurus_UMD|evm.model.AC_000160.1.313 Q96LB8 PGRP4_HUMAN 75.227 0.90884 0.970509 PGLYRP4 - Peptidoglycan recognition protein 4 precursor - Homo sapiens (Human) - PGLYRP4 gene Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. Taurus_UMD|evm.model.AC_000160.1.314 Q96LB9 PGRP3_HUMAN 79.128 0.846561 1.1085 PGLYRP3 - Peptidoglycan recognition protein 3 precursor - Homo sapiens (Human) - PGLYRP3 gene Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity. Taurus_UMD|evm.model.AC_000160.1.326 Q28658 SPRR3_RABIT 63.333 0.82243 0.463203 SPRR3 - Small proline-rich protein 3 - Oryctolagus cuniculus (Rabbit) - SPRR3 gene Can serve as a substrate in transglutaminase-catalyzed cross linking reactions and can function as a cross-linked envelope precursor. Taurus_UMD|evm.model.AC_000160.1.328 Q96PI1 SPRR4_HUMAN 87.500 0.618421 0.962025 SPRR4 - Small proline-rich protein 4 - Homo sapiens (Human) - SPRR4 gene Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification. Taurus_UMD|evm.model.AC_000160.1.330 P18175 INVO_PIG 78.571 0.192635 1.01729 IVL - Involucrin - Sus scrofa (Pig) - IVL gene Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Taurus_UMD|evm.model.AC_000160.1.334 O14633 LCE2B_HUMAN 64.789 0.653846 0.945455 LCE2B - Late cornified envelope protein 2B - Homo sapiens (Human) - LCE2B gene Precursors of the cornified envelope of the stratum corneum. Taurus_UMD|evm.model.AC_000160.1.338 Q5T5A8 LCE3C_HUMAN 66.038 0.362903 1.31915 LCE3C - Late cornified envelope protein 3C - Homo sapiens (Human) - LCE3C gene A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens (PubMed:28634035). Taurus_UMD|evm.model.AC_000160.1.340 Q3SZN2 SC23B_BOVIN 75.000 0.440789 0.198175 SEC23B - Protein transport protein Sec23B - Bos taurus (Bovine) - SEC23B gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Taurus_UMD|evm.model.AC_000160.1.341 Q7Z434 MAVS_HUMAN 61.392 0.928994 0.312963 MAVS - Mitochondrial antiviral-signaling protein - Homo sapiens (Human) - MAVS gene Required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:20127681, PubMed:21170385). Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:25636800, PubMed:20127681, PubMed:21170385, PubMed:20628368). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Taurus_UMD|evm.model.AC_000160.1.343 Q5R4V4 SARNP_PONAB 90.643 0.85 0.952381 SARNP - SAP domain-containing ribonucleoprotein - Pongo abelii (Sumatran orangutan) - SARNP gene Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity). Taurus_UMD|evm.model.AC_000160.1.344 Q9UBG3 CRNN_HUMAN 58.981 0.47125 1.61616 CRNN - Cornulin - Homo sapiens (Human) - CRNN gene Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1 (PubMed:30009832). Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways (PubMed:30009832). Taurus_UMD|evm.model.AC_000160.1.345 Q5D862 FILA2_HUMAN 80.090 0.626781 0.146801 FLG2 - Filaggrin-2 - Homo sapiens (Human) - FLG2 gene Essential for normal cell-cell adhesion in the cornified cell layers (PubMed:29758285). Important for proper integrity and mechanical strength of the stratum corneum of the epidermis (PubMed:29505760). Taurus_UMD|evm.model.AC_000160.1.347 Q5D862 FILA2_HUMAN 67.647 0.16792 0.166876 FLG2 - Filaggrin-2 - Homo sapiens (Human) - FLG2 gene Essential for normal cell-cell adhesion in the cornified cell layers (PubMed:29758285). Important for proper integrity and mechanical strength of the stratum corneum of the epidermis (PubMed:29505760). Taurus_UMD|evm.model.AC_000160.1.348 Q2VIS4 FILA2_MOUSE 51.485 0.06035 0.701524 Flg2 - Filaggrin-2 - Mus musculus (Mouse) - Flg2 gene Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. Taurus_UMD|evm.model.AC_000160.1.349 Q8VHD8 HORN_MOUSE 71.053 0.0969814 0.623798 Hrnr - Hornerin - Mus musculus (Mouse) - Hrnr gene Component of the epidermal cornified cell envelopes. Taurus_UMD|evm.model.AC_000160.1.350 Q6XPR3 RPTN_HUMAN 65.000 0.48037 1.65689 RPTN - Repetin - Homo sapiens (Human) - RPTN gene Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium. Taurus_UMD|evm.model.AC_000160.1.351 P22793 TRHY_SHEEP 73.472 0.435336 0.913493 TCHH - Trichohyalin - Ovis aries (Sheep) - TCHH gene Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. Taurus_UMD|evm.model.AC_000160.1.352 A6QP92 TCHL1_BOVIN 99.771 0.997709 1.00115 TCHHL1 - Trichohyalin-like protein 1 - Bos taurus (Bovine) - TCHHL1 gene Taurus_UMD|evm.model.AC_000160.1.353 Q6XPR3 RPTN_HUMAN 51.190 0.076639 1.38138 RPTN - Repetin - Homo sapiens (Human) - RPTN gene Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium. Taurus_UMD|evm.model.AC_000160.1.354 P31950 S10AB_PIG 90.323 0.713178 1.30303 S100A11 - Protein S100-A11 - Sus scrofa (Pig) - S100A11 gene Facilitates the differentiation and the cornification of keratinocytes. Taurus_UMD|evm.model.AC_000160.1.355 Q6SQH4 S10AA_RABIT 100.000 0.977778 0.927835 S100a10 - Protein S100-A10 - Oryctolagus cuniculus (Rabbit) - S100a10 gene Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. Taurus_UMD|evm.model.AC_000160.1.356 A1A4L1 THEM4_BOVIN 76.786 0.440722 1.63713 THEM4 - Acyl-coenzyme A thioesterase THEM4 precursor - Bos taurus (Bovine) - THEM4 gene Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (By similarity). Taurus_UMD|evm.model.AC_000160.1.357 B7Z1M9 C2D4D_HUMAN 84.136 0.994236 0.983003 C2CD4D - C2 calcium-dependent domain-containing protein 4D - Homo sapiens (Human) - C2CD4D gene Taurus_UMD|evm.model.AC_000160.1.358 P51449 RORG_HUMAN 90.154 0.996146 1.00193 RORC - Nuclear receptor ROR-gamma - Homo sapiens (Human) - RORC gene Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A (PubMed:19965867). Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC1 and PCK1 (PubMed:19965867). Regulates the rhythmic expression of PROX1 and promotes its nuclear localization (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (PubMed:26160376). Taurus_UMD|evm.model.AC_000160.1.360 Q6UY18 LIGO4_HUMAN 92.088 0.996639 1.00337 LINGO4 - Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4 precursor - Homo sapiens (Human) - LINGO4 gene extracellular matrix, extracellular space Taurus_UMD|evm.model.AC_000160.1.361 Q80VL1 TDRKH_MOUSE 90.893 0.994652 1.00179 Tdrkh - Tudor and KH domain-containing protein - Mus musculus (Mouse) - Tdrkh gene Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules. Taurus_UMD|evm.model.AC_000160.1.362 Q9UMX2 OAZ3_HUMAN 80.734 0.90411 0.931915 OAZ3 - Ornithine decarboxylase antizyme 3 - Homo sapiens (Human) - OAZ3 gene Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.363 Q2TBK2 RM09_BOVIN 100.000 0.992565 1.00373 MRPL9 - 39S ribosomal protein L9, mitochondrial precursor - Bos taurus (Bovine) - MRPL9 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion Taurus_UMD|evm.model.AC_000160.1.364 Q32PB2 RIAD1_BOVIN 100.000 0.978495 1.01087 RIIAD1 - RIIa domain-containing protein 1 - Bos taurus (Bovine) - RIIAD1 gene Taurus_UMD|evm.model.AC_000160.1.365 Q08E07 CELF3_BOVIN 99.784 0.99568 1.00434 CELF3 - CUGBP Elav-like family member 3 - Bos taurus (Bovine) - CELF3 gene RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). Taurus_UMD|evm.model.AC_000160.1.366 A5PKA5 SNX27_BOVIN 100.000 0.99631 1.00185 SNX27 - Sorting nexin-27 - Bos taurus (Bovine) - SNX27 gene Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes (By similarity). Taurus_UMD|evm.model.AC_000160.1.367 P27628 TUFT1_BOVIN 99.231 0.994885 1.00256 TUFT1 - Tuftelin - Bos taurus (Bovine) - TUFT1 gene Involved in the mineralization and structural organization of enamel. Taurus_UMD|evm.model.AC_000160.1.368 A9X1A5 CING_PAPAN 87.719 0.980992 1.01086 CGN - Cingulin - Papio anubis (Olive baboon) - CGN gene Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Taurus_UMD|evm.model.AC_000160.1.369 Q7Z3K3 POGZ_HUMAN 95.966 0.909794 1.10071 POGZ - Pogo transposable element with ZNF domain - Homo sapiens (Human) - POGZ gene Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms. Taurus_UMD|evm.model.AC_000160.1.370 Q3T108 PSB4_BOVIN 100.000 0.992453 1.00379 PSMB4 - Proteasome subunit beta type-4 precursor - Bos taurus (Bovine) - PSMB4 gene Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Taurus_UMD|evm.model.AC_000160.1.371 Q2KJ32 SBP1_BOVIN 100.000 0.995772 1.00212 SELENBP1 - Methanethiol oxidase - Bos taurus (Bovine) - SELENBP1 gene Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (By similarity). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport. Taurus_UMD|evm.model.AC_000160.1.372 P48382 RFX5_HUMAN 87.500 0.823056 1.21104 RFX5 - DNA-binding protein RFX5 - Homo sapiens (Human) - RFX5 gene Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. Taurus_UMD|evm.model.AC_000160.1.373 O02810 PI4KB_BOVIN 97.917 0.98401 0.996324 PI4KB - Phosphatidylinositol 4-kinase beta - Bos taurus (Bovine) - PI4KB gene Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP) (PubMed:9218477, PubMed:11526106). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity). Taurus_UMD|evm.model.AC_000160.1.374 Q8N1G0 ZN687_HUMAN 90.638 0.981717 1.01698 ZNF687 - Zinc finger protein 687 - Homo sapiens (Human) - ZNF687 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000160.1.375 Q2MHN1 FRIL_FELCA 78.049 0.931034 0.497143 FTL - Ferritin light chain - Felis catus (Cat) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000160.1.376 Q58DA0 PSMD4_BOVIN 100.000 0.994778 1.00262 PSMD4 - 26S proteasome non-ATPase regulatory subunit 4 - Bos taurus (Bovine) - PSMD4 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. Taurus_UMD|evm.model.AC_000160.1.377 Q99755 PI51A_HUMAN 91.392 0.967273 0.978648 PIP5K1A - Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha - Homo sapiens (Human) - PIP5K1A gene Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:8955136, PubMed:21477596, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (PubMed:19158393, PubMed:20660631). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (PubMed:22942276). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (PubMed:19158393). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:20660631). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197). Taurus_UMD|evm.model.AC_000160.1.378 P61078 UB2D3_RAT 89.116 0.80663 1.23129 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Taurus_UMD|evm.model.AC_000160.1.379 Q5E9F6 VPS72_BOVIN 100.000 0.994521 1.00275 VPS72 - Vacuolar protein sorting-associated protein 72 homolog - Bos taurus (Bovine) - VPS72 gene Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Taurus_UMD|evm.model.AC_000160.1.380 Q0VC48 TMOD4_BOVIN 100.000 0.99422 1.0029 TMOD4 - Tropomodulin-4 - Bos taurus (Bovine) - TMOD4 gene Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). Taurus_UMD|evm.model.AC_000160.1.381 Q3ZBR0 SCNM1_BOVIN 100.000 0.991342 1.00435 SCNM1 - Sodium channel modifier 1 - Bos taurus (Bovine) - SCNM1 gene Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites. Taurus_UMD|evm.model.AC_000160.1.382 A0JNI1 LYSM1_BOVIN 99.556 0.99115 1.00444 LYSMD1 - LysM and putative peptidoglycan-binding domain-containing protein 1 - Bos taurus (Bovine) - LYSMD1 gene Taurus_UMD|evm.model.AC_000160.1.383 Q3ZBK5 TP8L2_BOVIN 100.000 0.989189 1.00543 TNFAIP8L2 - Tumor necrosis factor alpha-induced protein 8-like protein 2 - Bos taurus (Bovine) - TNFAIP8L2 gene Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity). Taurus_UMD|evm.model.AC_000160.1.384 Q9WTL3 SEM6C_RAT 87.794 0.974922 0.996875 Sema6c - Semaphorin-6C precursor - Rattus norvegicus (Rat) - Sema6c gene Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Taurus_UMD|evm.model.AC_000160.1.385 Q0V8G2 GABP2_BOVIN 100.000 0.995536 1.00224 GABPB2 - GA-binding protein subunit beta-2 - Bos taurus (Bovine) - GABPB2 gene May function as transcription factor capable of interacting with purine rich repeats (GA repeats). Taurus_UMD|evm.model.AC_000160.1.386 Q0VCT1 AF1Q_BOVIN 86.957 0.383966 2.63333 MLLT11 - Protein AF1q - Bos taurus (Bovine) - MLLT11 gene Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T-cell fate. Taurus_UMD|evm.model.AC_000160.1.387 Q8BHL7 C42S1_MOUSE 98.214 0.325444 2.1125 Cdc42se1 - CDC42 small effector protein 1 - Mus musculus (Mouse) - Cdc42se1 gene Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity). Taurus_UMD|evm.model.AC_000160.1.388 Q9BUN1 MENT_HUMAN 62.360 0.99435 1.03812 MENT - Protein MENT precursor - Homo sapiens (Human) - MENT gene Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B. Taurus_UMD|evm.model.AC_000160.1.389 Q7Z465 BNIPL_HUMAN 87.430 0.994398 1 BNIPL - Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein - Homo sapiens (Human) - BNIPL gene May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Taurus_UMD|evm.model.AC_000160.1.390 Q5E9Y6 PRUN1_BOVIN 100.000 0.995595 1.00221 PRUNE1 - Exopolyphosphatase PRUNE1 - Bos taurus (Bovine) - PRUNE1 gene Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1 (By similarity). Taurus_UMD|evm.model.AC_000160.1.391 Q2KJ22 MINY1_BOVIN 99.787 0.995745 1.00213 MINDY1 - Ubiquitin carboxyl-terminal hydrolase MINDY-1 - Bos taurus (Bovine) - MINDY1 gene Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. Taurus_UMD|evm.model.AC_000160.1.392 Q3ZC08 ANXA9_BOVIN 99.420 0.82494 1.2087 ANXA9 - Annexin A9 - Bos taurus (Bovine) - ANXA9 gene May act as a low affinity receptor for acetylcholine. Taurus_UMD|evm.model.AC_000160.1.393 Q3ZBF8 CERS2_BOVIN 100.000 0.961929 1.03684 CERS2 - Ceramide synthase 2 - Bos taurus (Bovine) - CERS2 gene Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) chain as acyl donor (By similarity). May regulate lipid metabolism in hepatocytes (By similarity). Taurus_UMD|evm.model.AC_000160.1.394 Q15047 SETB1_HUMAN 96.365 0.998451 1 SETDB1 - Histone-lysine N-methyltransferase SETDB1 - Homo sapiens (Human) - SETDB1 gene Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:27732843, PubMed:14536086). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086,). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Taurus_UMD|evm.model.AC_000160.1.395 Q9BE97 ARNT_BOVIN 99.494 0.997472 1.00127 ARNT - Aryl hydrocarbon receptor nuclear translocator - Bos taurus (Bovine) - ARNT gene Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity). Taurus_UMD|evm.model.AC_000160.1.396 Q5E968 CATK_BOVIN 100.000 0.979104 1.01824 CTSK - Cathepsin K precursor - Bos taurus (Bovine) - CTSK gene Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Taurus_UMD|evm.model.AC_000160.1.397 Q712U6 ARP19_PIG 78.571 0.981982 0.991071 ARPP19 - cAMP-regulated phosphoprotein 19 - Sus scrofa (Pig) - ARPP19 gene Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA (By similarity). Taurus_UMD|evm.model.AC_000160.1.398 P25326 CATS_BOVIN 100.000 0.993976 1.00302 CTSS - Cathepsin S precursor - Bos taurus (Bovine) - CTSS gene Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. Taurus_UMD|evm.model.AC_000160.1.399 Q2KIY6 HORM1_BOVIN 100.000 0.994924 1.00254 HORMAD1 - HORMA domain-containing protein 1 - Bos taurus (Bovine) - HORMAD1 gene Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Taurus_UMD|evm.model.AC_000160.1.400 A6H7F6 GLP3L_BOVIN 100.000 0.993007 1.00351 GOLPH3L - Golgi phosphoprotein 3-like - Bos taurus (Bovine) - GOLPH3L gene Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. Taurus_UMD|evm.model.AC_000160.1.401 O43768 ENSA_HUMAN 99.145 0.983051 0.975207 ENSA - Alpha-endosulfine - Homo sapiens (Human) - ENSA gene Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. Taurus_UMD|evm.model.AC_000160.1.402 Q7YRZ9 MCL1_FELCA 90.313 0.994302 1.00286 MCL1 - Induced myeloid leukemia cell differentiation protein Mcl-1 homolog - Felis catus (Cat) - MCL1 gene Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity). Taurus_UMD|evm.model.AC_000160.1.403 Q6UY14 ATL4_HUMAN 86.047 0.998133 0.997207 ADAMTSL4 - ADAMTS-like protein 4 precursor - Homo sapiens (Human) - ADAMTSL4 gene Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. Taurus_UMD|evm.model.AC_000160.1.404 Q16610 ECM1_HUMAN 74.727 0.862776 1.17407 ECM1 - Extracellular matrix protein 1 precursor - Homo sapiens (Human) - ECM1 gene Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. Taurus_UMD|evm.model.AC_000160.1.405 Q9BW92 SYTM_HUMAN 88.022 0.997218 1.00139 TARS2 - Threonine--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - TARS2 gene Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain. Taurus_UMD|evm.model.AC_000160.1.406 Q5VT52 RPRD2_HUMAN 94.564 0.960429 1.02053 RPRD2 - Regulation of nuclear pre-mRNA domain-containing protein 2 - Homo sapiens (Human) - RPRD2 gene nucleoplasm, RNA polymerase II, holoenzyme, RNA polymerase II complex binding, mRNA 3'-end processing, snRNA transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000160.1.407 O43395 PRPF3_HUMAN 100.000 0.898551 1.11127 PRPF3 - U4/U6 small nuclear ribonucleoprotein Prp3 - Homo sapiens (Human) - PRPF3 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). Taurus_UMD|evm.model.AC_000160.1.408 Q8N365 CIART_HUMAN 80.729 0.992228 1.0026 CIART - Circadian-associated transcriptional repressor - Homo sapiens (Human) - CIART gene Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity). Taurus_UMD|evm.model.AC_000160.1.409 Q148C7 CA054_BOVIN 100.000 0.984848 1.00763 Uncharacterized protein C1orf54 homolog precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000160.1.410 Q8BVF7 APH1A_MOUSE 98.868 0.992481 1.00377 Aph1a - Gamma-secretase subunit APH-1A - Mus musculus (Mouse) - Aph1a gene Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:15634781, PubMed:19369254). Required for normal gamma-secretase assembly (PubMed:15634781, PubMed:19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). Taurus_UMD|evm.model.AC_000160.1.411 Q9ULX7 CAH14_HUMAN 87.126 0.988131 1 CA14 - Carbonic anhydrase 14 precursor - Homo sapiens (Human) - CA14 gene Reversible hydration of carbon dioxide. Taurus_UMD|evm.model.AC_000160.1.412 Q9BTT0 AN32E_HUMAN 97.386 0.569288 0.996269 ANP32E - Acidic leucine-rich nuclear phosphoprotein 32 family member E - Homo sapiens (Human) - ANP32E gene Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. Taurus_UMD|evm.model.AC_000160.1.413 A4IFK0 PKHO1_BOVIN 99.756 0.995122 1.00244 PLEKHO1 - Pleckstrin homology domain-containing family O member 1 - Bos taurus (Bovine) - PLEKHO1 gene Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity). Taurus_UMD|evm.model.AC_000160.1.414 Q9NRW7 VPS45_HUMAN 98.596 0.996497 1.00175 VPS45 - Vacuolar protein sorting-associated protein 45 - Homo sapiens (Human) - VPS45 gene May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network. Taurus_UMD|evm.model.AC_000160.1.415 Q6GQQ9 OTU7B_HUMAN 93.713 0.803435 1.24318 OTUD7B - OTU domain-containing protein 7B - Homo sapiens (Human) - OTUD7B gene Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin. Taurus_UMD|evm.model.AC_000160.1.416 A4FU01 MTMRB_HUMAN 90.531 0.992847 0.985896 MTMR11 - Myotubularin-related protein 11 - Homo sapiens (Human) - MTMR11 gene cytoplasm, extracellular exosome, phosphatidylinositol-3-phosphatase activity, phosphatidylinositol dephosphorylation Taurus_UMD|evm.model.AC_000160.1.417 Q15427 SF3B4_HUMAN 99.764 0.995294 1.00236 SF3B4 - Splicing factor 3B subunit 4 - Homo sapiens (Human) - SF3B4 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). Taurus_UMD|evm.model.AC_000160.1.418 Q29397 SV2A_BOVIN 100.000 0.997308 1.00135 SV2A - Synaptic vesicle glycoprotein 2A - Bos taurus (Bovine) - SV2A gene Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). Taurus_UMD|evm.model.AC_000160.1.419 Q3T138 BOLA1_BOVIN 100.000 0.985294 1.00741 BOLA1 - BolA-like protein 1 - Bos taurus (Bovine) - BOLA1 gene Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5. May protect cells against oxidative stress (By similarity). Taurus_UMD|evm.model.AC_000160.1.420 Q8IUE6 H2A2B_HUMAN 100.000 0.984733 1.00769 H2AC21 - Histone H2A type 2-B - Homo sapiens (Human) - H2AC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000160.1.421 Q64523 H2A2C_MOUSE 99.083 0.670807 1.24806 H2ac20 - Histone H2A type 2-C - Mus musculus (Mouse) - H2ac20 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000160.1.422 Q16778 H2B2E_HUMAN 99.206 0.984252 1.00794 H2BC21 - Histone H2B type 2-E - Homo sapiens (Human) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000160.1.423 P84232 H32_PORAF 100.000 0.985401 1.00735 Histone H3.2 - Poroderma africanum (Striped catshark) Taurus_UMD|evm.model.AC_000160.1.424 P0CC09 H2A2A_RAT 100.000 0.984733 1.00769 H2ac18 - Histone H2A type 2-A - Rattus norvegicus (Rat) - H2ac18 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Taurus_UMD|evm.model.AC_000160.1.425 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000160.1.426 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000160.1.427 P0CC09 H2A2A_RAT 100.000 0.984733 1.00769 H2ac18 - Histone H2A type 2-A - Rattus norvegicus (Rat) - H2ac18 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Taurus_UMD|evm.model.AC_000160.1.428 P84232 H32_PORAF 100.000 0.985401 1.00735 Histone H3.2 - Poroderma africanum (Striped catshark) Taurus_UMD|evm.model.AC_000160.1.429 Q6WV90 H4_MYTGA 100.000 0.675497 1.46602 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000160.1.430 P84232 H32_PORAF 100.000 0.985401 1.00735 Histone H3.2 - Poroderma africanum (Striped catshark) Taurus_UMD|evm.model.AC_000160.1.431 Q5QNW6 H2B2F_HUMAN 100.000 0.984252 1.00794 H2BC18 - Histone H2B type 2-F - Homo sapiens (Human) - H2BC18 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000160.1.432 P12314 FCGR1_HUMAN 67.941 0.968571 0.935829 FCGR1A - High affinity immunoglobulin gamma Fc receptor I precursor - Homo sapiens (Human) - FCGR1A gene High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Taurus_UMD|evm.model.AC_000160.1.433 Q5VU43 MYOME_HUMAN 51.538 0.350427 0.149616 PDE4DIP - Myomegalin - Homo sapiens (Human) - PDE4DIP gene Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). Taurus_UMD|evm.model.AC_000160.1.434 Q32LC2 NBP6L_BOVIN 100.000 0.933054 1.06696 Neuroblastoma breakpoint family member 6-like protein - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000160.1.435 P62752 RL23A_RAT 98.246 0.974138 0.74359 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000160.1.438 Q32LC2 NBP6L_BOVIN 80.435 0.156794 1.28125 Neuroblastoma breakpoint family member 6-like protein - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000160.1.439 Q6ZVN8 RGMC_HUMAN 90.465 0.995327 1.00469 HJV - Hemojuvelin precursor - Homo sapiens (Human) - HJV gene Acts as a bone morphogenetic protein (BMP) coreceptor (PubMed:18976966). Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis (PubMed:18976966). Taurus_UMD|evm.model.AC_000160.1.440 Q2HY40 TXNIP_PIG 95.396 0.994898 1.00256 TXNIP - Thioredoxin-interacting protein - Sus scrofa (Pig) - TXNIP gene May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth (By similarity). Taurus_UMD|evm.model.AC_000160.1.441 Q1RMR0 RPC7L_BOVIN 100.000 0.745704 1.33486 POLR3GL - DNA-directed RNA polymerase III subunit RPC7-like - Bos taurus (Bovine) - POLR3GL gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Taurus_UMD|evm.model.AC_000160.1.443 Q5BJT1 AN34A_RAT 96.573 0.99596 1 Ankrd34a - Ankyrin repeat domain-containing protein 34A - Rattus norvegicus (Rat) - Ankrd34a gene Taurus_UMD|evm.model.AC_000160.1.444 Q27W01 RBM8A_RAT 100.000 0.344622 2.88506 Rbm8a - RNA-binding protein 8A - Rattus norvegicus (Rat) - Rbm8a gene Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity). Taurus_UMD|evm.model.AC_000160.1.445 Q95MG6 GNRR2_CALJA 87.121 0.642157 0.536842 GNRHR2 - Gonadotropin-releasing hormone II receptor - Callithrix jacchus (White-tufted-ear marmoset) - GNRHR2 gene Receptor for gonadotropin releasing hormone II (GnRH II). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000160.1.446 Q148K5 PX11B_BOVIN 100.000 0.992278 1.00388 PEX11B - Peroxisomal membrane protein 11B - Bos taurus (Bovine) - PEX11B gene Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface. Taurus_UMD|evm.model.AC_000160.1.447 O75578 ITA10_HUMAN 91.486 0.984589 1.00086 ITGA10 - Integrin alpha-10 precursor - Homo sapiens (Human) - ITGA10 gene Integrin alpha-10/beta-1 is a receptor for collagen. Taurus_UMD|evm.model.AC_000160.1.448 Q8N283 ANR35_HUMAN 84.263 0.99801 1.004 ANKRD35 - Ankyrin repeat domain-containing protein 35 - Homo sapiens (Human) - ANKRD35 gene Taurus_UMD|evm.model.AC_000160.1.449 Q9Y6X2 PIAS3_HUMAN 98.089 0.99682 1.00159 PIAS3 - E3 SUMO-protein ligase PIAS3 - Homo sapiens (Human) - PIAS3 gene Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376). Taurus_UMD|evm.model.AC_000160.1.450 A4FUG7 NUD17_BOVIN 100.000 0.993266 0.983444 NUDT17 - Nucleoside diphosphate-linked moiety X motif 17 - Bos taurus (Bovine) - NUDT17 gene Probably mediates the hydrolysis of some nucleoside diphosphate derivatives. Taurus_UMD|evm.model.AC_000160.1.451 Q2TBL4 RPC3_BOVIN 99.812 0.996255 1.00188 POLR3C - DNA-directed RNA polymerase III subunit RPC3 - Bos taurus (Bovine) - POLR3C gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF-Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner. Taurus_UMD|evm.model.AC_000160.1.452 Q0II22 RN126_BOVIN 76.087 0.361111 0.805112 RNF126 - E3 ubiquitin-protein ligase RNF126 - Bos taurus (Bovine) - RNF126 gene E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor. May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination. By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation. May monoubiquitinate AICDA. Taurus_UMD|evm.model.AC_000160.1.453 Q3T0X8 NHRF3_BOVIN 100.000 0.996161 1.00192 PDZK1 - Na(+)/H(+) exchange regulatory cofactor NHE-RF3 - Bos taurus (Bovine) - PDZK1 gene A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity). Taurus_UMD|evm.model.AC_000160.1.454 Q5BIM9 GPHR_BOVIN 100.000 0.573386 1.12308 GPR89 - Golgi pH regulator - Bos taurus (Bovine) - GPR89 gene Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (By similarity). Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.455 P55917 CXA8_SHEEP 97.955 0.995465 1.00227 GJA8 - Gap junction alpha-8 protein - Ovis aries (Sheep) - GJA8 gene Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore. Taurus_UMD|evm.model.AC_000160.1.456 Q0VCR2 CXA5_BOVIN 99.443 0.994444 1.00279 GJA5 - Gap junction alpha-5 protein - Bos taurus (Bovine) - GJA5 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Taurus_UMD|evm.model.AC_000160.1.457 A6H757 PPA6_BOVIN 100.000 0.995349 1.00233 ACP6 - Lysophosphatidic acid phosphatase type 6 precursor - Bos taurus (Bovine) - ACP6 gene Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. Taurus_UMD|evm.model.AC_000160.1.458 Q95KQ6 BCL9_PIG 100.000 0.167098 5.93846 BCL9 - B-cell CLL/lymphoma 9 protein - Sus scrofa (Pig) - BCL9 gene Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). Taurus_UMD|evm.model.AC_000160.1.459 O00512 BCL9_HUMAN 94.737 0.996909 0.453717 BCL9 - B-cell CLL/lymphoma 9 protein - Homo sapiens (Human) - BCL9 gene Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). Taurus_UMD|evm.model.AC_000160.1.460 Q3B7N1 CHD1L_BOVIN 95.706 0.997644 0.946488 CHD1L - Chromodomain-helicase-DNA-binding protein 1-like - Bos taurus (Bovine) - CHD1L gene DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding. Taurus_UMD|evm.model.AC_000160.1.461 P49326 FMO5_HUMAN 85.178 0.996255 1.00188 FMO5 - Flavin-containing monooxygenase 5 - Homo sapiens (Human) - FMO5 gene Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters (PubMed:28783300, PubMed:26771671, PubMed:20947616). Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive (PubMed:26771671, PubMed:7872795). In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable) (PubMed:7872795). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline (PubMed:28783300). Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (PubMed:26771671). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity). Taurus_UMD|evm.model.AC_000160.1.462 O43741 AAKB2_HUMAN 98.897 0.992674 1.00368 PRKAB2 - 5'-AMP-activated protein kinase subunit beta-2 - Homo sapiens (Human) - PRKAB2 gene Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). Taurus_UMD|evm.model.AC_000160.1.463 P0C2Y1 NBPF7_HUMAN 40.104 0.703846 0.617577 NBPF7 - Putative neuroblastoma breakpoint family member 7 - Homo sapiens (Human) - NBPF7 gene Taurus_UMD|evm.model.AC_000160.1.464 Q9WUJ3 MYOME_RAT 82.500 0.220339 0.0761618 Pde4dip - Myomegalin - Rattus norvegicus (Rat) - Pde4dip gene Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (PubMed:11134006). May participate in microtubule dynamics, promoting microtubule assembly, in an isoform-specific manner. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome. In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (By similarity). Taurus_UMD|evm.model.AC_000160.1.465 Q3BBV0 NBPF1_HUMAN 43.621 0.369497 0.523888 NBPF1 - Neuroblastoma breakpoint family member 1 - Homo sapiens (Human) - NBPF1 gene Taurus_UMD|evm.model.AC_000160.1.466 Q3BBV0 NBPF1_HUMAN 44.444 0.416667 0.46458 NBPF1 - Neuroblastoma breakpoint family member 1 - Homo sapiens (Human) - NBPF1 gene Taurus_UMD|evm.model.AC_000160.1.467 Q5VU43 MYOME_HUMAN 85.357 0.924617 1.08568 PDE4DIP - Myomegalin - Homo sapiens (Human) - PDE4DIP gene Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). Taurus_UMD|evm.model.AC_000160.1.468 Q4KM74 SC22B_RAT 99.535 0.990741 1.00465 Sec22b - Vesicle-trafficking protein SEC22b - Rattus norvegicus (Rat) - Sec22b gene SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. Taurus_UMD|evm.model.AC_000160.1.469 Q04721 NOTC2_HUMAN 87.914 0.999165 0.968839 NOTCH2 - Neurogenic locus notch homolog protein 2 precursor - Homo sapiens (Human) - NOTCH2 gene Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). Taurus_UMD|evm.model.AC_000160.1.470 Q9UKF2 ADA30_HUMAN 66.059 0.993007 0.905063 ADAM30 - Disintegrin and metalloproteinase domain-containing protein 30 precursor - Homo sapiens (Human) - ADAM30 gene Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034). Taurus_UMD|evm.model.AC_000160.1.471 Q9UKF2 ADA30_HUMAN 66.993 0.993026 0.907595 ADAM30 - Disintegrin and metalloproteinase domain-containing protein 30 precursor - Homo sapiens (Human) - ADAM30 gene Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034). Taurus_UMD|evm.model.AC_000160.1.472 Q9UKF2 ADA30_HUMAN 66.948 0.977901 0.916456 ADAM30 - Disintegrin and metalloproteinase domain-containing protein 30 precursor - Homo sapiens (Human) - ADAM30 gene Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034). Taurus_UMD|evm.model.AC_000160.1.473 Q9D8G5 REG4_MOUSE 59.286 0.706215 1.12739 Reg4 - Regenerating islet-derived protein 4 precursor - Mus musculus (Mouse) - Reg4 gene Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity). Taurus_UMD|evm.model.AC_000160.1.474 Q2KIE6 HMCS2_BOVIN 100.000 0.996071 1.00197 HMGCS2 - Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor - Bos taurus (Bovine) - HMGCS2 gene Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. Taurus_UMD|evm.model.AC_000160.1.475 Q5EAD2 SERA_BOVIN 99.625 0.996255 1.00188 PHGDH - D-3-phosphoglycerate dehydrogenase - Bos taurus (Bovine) - PHGDH gene Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. Taurus_UMD|evm.model.AC_000160.1.476 Q5TEC3 ZN697_HUMAN 89.130 0.99637 1.01101 ZNF697 - Zinc finger protein 697 - Homo sapiens (Human) - ZNF697 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000160.1.477 P14893 3BHS_BOVIN 100.000 0.49534 2.0134 HSD3B - 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase - Bos taurus (Bovine) - HSD3B gene 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Taurus_UMD|evm.model.AC_000160.1.478 Q3T099 SYWM_BOVIN 100.000 0.99446 1.00278 WARS2 - Tryptophan--tRNA ligase, mitochondrial precursor - Bos taurus (Bovine) - WARS2 gene Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis. Taurus_UMD|evm.model.AC_000160.1.479 Q96SF7 TBX15_HUMAN 93.355 0.987889 0.960133 TBX15 - T-box transcription factor TBX15 - Homo sapiens (Human) - TBX15 gene Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity). Taurus_UMD|evm.model.AC_000160.1.480 Q9NTZ6 RBM12_HUMAN 79.320 0.449664 0.799356 RBM12 - RNA-binding protein 12 - Homo sapiens (Human) - RBM12 gene nucleoplasm, ribonucleoprotein complex, RNA binding, regulation of RNA splicing Taurus_UMD|evm.model.AC_000160.1.483 Q9UNX4 WDR3_HUMAN 94.486 0.997881 1.00106 WDR3 - WD repeat-containing protein 3 - Homo sapiens (Human) - WDR3 gene nuclear membrane, nucleolus, nucleoplasm, Pwp2p-containing subcomplex of 90S preribosome, small-subunit processome, RNA binding, snoRNA binding, maturation of SSU-rRNA, rRNA processing Taurus_UMD|evm.model.AC_000160.1.485 Q2KIX2 GDAP2_BOVIN 100.000 0.995984 1.00201 GDAP2 - Ganglioside-induced differentiation-associated protein 2 - Bos taurus (Bovine) - GDAP2 gene Taurus_UMD|evm.model.AC_000160.1.486 Q4R8X4 TET5C_MACFA 94.751 0.925641 0.997442 TENT5C - Terminal nucleotidyltransferase 5C - Macaca fascicularis (Crab-eating macaque) - TENT5C gene Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death. Taurus_UMD|evm.model.AC_000160.1.487 Q3T0M7 RANG_BOVIN 97.826 0.957895 0.461165 RANBP1 - Ran-specific GTPase-activating protein - Bos taurus (Bovine) - RANBP1 gene Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN. Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (By similarity). Taurus_UMD|evm.model.AC_000160.1.488 O60476 MA1A2_HUMAN 95.632 0.996885 1.00156 MAN1A2 - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB - Homo sapiens (Human) - MAN1A2 gene Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). Taurus_UMD|evm.model.AC_000160.1.489 Q7Z7D3 VTCN1_HUMAN 91.339 0.798107 1.12411 VTCN1 - V-set domain-containing T-cell activation inhibitor 1 precursor - Homo sapiens (Human) - VTCN1 gene Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Taurus_UMD|evm.model.AC_000160.1.490 Q5BIM1 TRI45_BOVIN 100.000 0.996558 1.00172 TRIM45 - Tripartite motif-containing protein 45 - Bos taurus (Bovine) - TRIM45 gene May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway. Taurus_UMD|evm.model.AC_000160.1.491 Q9UNY4 TTF2_HUMAN 76.864 0.976471 1.0241 TTF2 - Transcription termination factor 2 - Homo sapiens (Human) - TTF2 gene DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000160.1.492 Q93033 IGSF2_HUMAN 75.852 0.989087 0.987267 CD101 - Immunoglobulin superfamily member 2 precursor - Homo sapiens (Human) - CD101 gene Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. Taurus_UMD|evm.model.AC_000160.1.493 Q9P2B2 FPRP_HUMAN 90.557 0.997727 1.00114 PTGFRN - Prostaglandin F2 receptor negative regulator precursor - Homo sapiens (Human) - PTGFRN gene Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity). Taurus_UMD|evm.model.AC_000160.1.494 P06729 CD2_HUMAN 53.468 0.9941 0.965812 CD2 - T-cell surface antigen CD2 precursor - Homo sapiens (Human) - CD2 gene CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. Taurus_UMD|evm.model.AC_000160.1.495 O75054 IGSF3_HUMAN 89.492 0.969572 1.01843 IGSF3 - Immunoglobulin superfamily member 3 precursor - Homo sapiens (Human) - IGSF3 gene cell surface, integral component of membrane, lacrimal gland development Taurus_UMD|evm.model.AC_000160.1.496 P19256 LFA3_HUMAN 47.541 0.971545 0.984 CD58 - Lymphocyte function-associated antigen 3 precursor - Homo sapiens (Human) - CD58 gene Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Taurus_UMD|evm.model.AC_000160.1.497 Q08DA1 AT1A1_BOVIN 100.000 0.978805 1.01665 ATP1A1 - Sodium/potassium-transporting ATPase subunit alpha-1 precursor - Bos taurus (Bovine) - ATP1A1 gene This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Taurus_UMD|evm.model.AC_000160.1.498 Q8N8X9 MB213_HUMAN 78.443 0.945714 0.966851 MAB21L3 - Protein mab-21-like 3 - Homo sapiens (Human) - MAB21L3 gene Taurus_UMD|evm.model.AC_000160.1.499 Q8IZD6 S22AF_HUMAN 94.516 0.99635 1.00183 SLC22A15 - Solute carrier family 22 member 15 - Homo sapiens (Human) - SLC22A15 gene Probably transports organic cations (By similarity). Appears not to be the agmatine transporter. Taurus_UMD|evm.model.AC_000160.1.500 Q02575 HEN1_HUMAN 98.387 0.455224 1.00752 NHLH1 - Helix-loop-helix protein 1 - Homo sapiens (Human) - NHLH1 gene May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. Taurus_UMD|evm.model.AC_000160.1.501 P12637 CASQ2_CANLF 96.505 0.858796 1.05366 CASQ2 - Calsequestrin-2 precursor - Canis lupus familiaris (Dog) - CASQ2 gene Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:3427023). Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. Taurus_UMD|evm.model.AC_000160.1.502 Q8TAA9 VANG1_HUMAN 79.008 0.995726 0.89313 VANGL1 - Vang-like protein 1 - Homo sapiens (Human) - VANGL1 gene plasma membrane, Wnt signaling pathway, planar cell polarity pathway Taurus_UMD|evm.model.AC_000160.1.503 P50890 RSSA_CHICK 67.816 0.693548 0.418919 RPSA - 40S ribosomal protein SA - Gallus gallus (Chicken) - RPSA gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Taurus_UMD|evm.model.AC_000160.1.504 P06576 ATPB_HUMAN 77.778 0.872549 0.192817 ATP5F1B - ATP synthase subunit beta, mitochondrial precursor - Homo sapiens (Human) - ATP5F1B gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Taurus_UMD|evm.model.AC_000160.1.506 Q2HJ94 DNJA2_BOVIN 92.937 0.992537 0.650485 DNAJA2 - DnaJ homolog subfamily A member 2 precursor - Bos taurus (Bovine) - DNAJA2 gene Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Taurus_UMD|evm.model.AC_000160.1.507 P13600 NGF_BOVIN 100.000 0.836237 1.19087 NGF - Beta-nerve growth factor precursor - Bos taurus (Bovine) - NGF gene Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity). Taurus_UMD|evm.model.AC_000160.1.508 O60636 TSN2_HUMAN 93.665 0.990991 1.00452 TSPAN2 - Tetraspanin-2 - Homo sapiens (Human) - TSPAN2 gene May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath. Taurus_UMD|evm.model.AC_000160.1.509 P01223 TSHB_BOVIN 100.000 0.985612 1.00725 TSHB - Thyrotropin subunit beta precursor - Bos taurus (Bovine) - TSHB gene Indispensable for the control of thyroid structure and metabolism. Taurus_UMD|evm.model.AC_000160.1.510 Q15431 SYCP1_HUMAN 77.400 0.997888 0.970287 SYCP1 - Synaptonemal complex protein 1 - Homo sapiens (Human) - SYCP1 gene Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Taurus_UMD|evm.model.AC_000160.1.511 Q28852 ATP5L_BOVIN 97.087 0.980769 1.00971 ATP5MG - ATP synthase subunit g, mitochondrial - Bos taurus (Bovine) - ATP5MG gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Taurus_UMD|evm.model.AC_000160.1.512 Q0VCF3 SIKE1_BOVIN 100.000 0.990385 1.00483 SIKE1 - Suppressor of IKBKE 1 - Bos taurus (Bovine) - SIKE1 gene Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). Taurus_UMD|evm.model.AC_000160.1.513 P29174 CSDE1_CAVPO 100.000 0.133728 7.41228 CSDE1 - Cold shock domain-containing protein E1 - Cavia porcellus (Guinea pig) - CSDE1 gene RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules. Taurus_UMD|evm.model.AC_000160.1.514 Q2MJK3 RASN_PIG 100.000 0.989474 1.00529 NRAS - GTPase NRas precursor - Sus scrofa (Pig) - NRAS gene Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Taurus_UMD|evm.model.AC_000160.1.515 P23109 AMPD1_HUMAN 83.471 0.784314 0.196154 AMPD1 - AMP deaminase 1 - Homo sapiens (Human) - AMPD1 gene AMP deaminase plays a critical role in energy metabolism. Taurus_UMD|evm.model.AC_000160.1.516 P23109 AMPD1_HUMAN 93.396 0.995298 0.817949 AMPD1 - AMP deaminase 1 - Homo sapiens (Human) - AMPD1 gene AMP deaminase plays a critical role in energy metabolism. Taurus_UMD|evm.model.AC_000160.1.517 Q68D51 DEN2C_HUMAN 91.183 0.991453 1.00862 DENND2C - DENN domain-containing protein 2C - Homo sapiens (Human) - DENND2C gene Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Taurus_UMD|evm.model.AC_000160.1.518 Q9D287 SPF27_MOUSE 98.222 0.99115 1.00444 Bcas2 - Pre-mRNA-splicing factor SPF27 - Mus musculus (Mouse) - Bcas2 gene Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). Taurus_UMD|evm.model.AC_000160.1.519 Q9UPN9 TRI33_HUMAN 97.516 0.998225 1 TRIM33 - E3 ubiquitin-protein ligase TRIM33 - Homo sapiens (Human) - TRIM33 gene Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). Taurus_UMD|evm.model.AC_000160.1.520 Q5T7P8 SYT6_HUMAN 96.832 0.877836 1.12353 SYT6 - Synaptotagmin-6 - Homo sapiens (Human) - SYT6 gene May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity). Taurus_UMD|evm.model.AC_000160.1.521 Q0VCP3 OLFL3_BOVIN 100.000 0.995086 1.00246 OLFML3 - Olfactomedin-like protein 3 precursor - Bos taurus (Bovine) - OLFML3 gene Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes (By similarity). Taurus_UMD|evm.model.AC_000160.1.523 Q86Z02 HIPK1_HUMAN 98.512 0.979741 1.01983 HIPK1 - Homeodomain-interacting protein kinase 1 - Homo sapiens (Human) - HIPK1 gene Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). Taurus_UMD|evm.model.AC_000160.1.524 D2H8V8 DCR1B_AILME 85.227 0.970534 1.02647 DCLRE1B - 5' exonuclease Apollo - Ailuropoda melanoleuca (Giant panda) - DCLRE1B gene 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint (By similarity). Taurus_UMD|evm.model.AC_000160.1.525 Q9Y6B7 AP4B1_HUMAN 92.963 0.997297 1.00135 AP4B1 - AP-4 complex subunit beta-1 - Homo sapiens (Human) - AP4B1 gene Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). Taurus_UMD|evm.model.AC_000160.1.526 Q0II48 B2L15_BOVIN 100.000 0.98773 1.00617 BCL2L15 - Bcl-2-like protein 15 - Bos taurus (Bovine) - BCL2L15 gene cytosol, nucleus Taurus_UMD|evm.model.AC_000160.1.527 Q9Y2R2 PTN22_HUMAN 73.613 0.997416 0.959108 PTPN22 - Tyrosine-protein phosphatase non-receptor type 22 - Homo sapiens (Human) - PTPN22 gene Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). Taurus_UMD|evm.model.AC_000160.1.528 Q5VWQ0 RSBN1_HUMAN 89.664 0.997361 0.945137 RSBN1 - Lysine-specific demethylase 9 - Homo sapiens (Human) - RSBN1 gene Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture. Taurus_UMD|evm.model.AC_000160.1.529 Q08DA4 PHTF1_BOVIN 97.507 0.997312 0.976378 PHTF1 - Protein PHTF1 - Bos taurus (Bovine) - PHTF1 gene Taurus_UMD|evm.model.AC_000160.1.530 Q5TCQ9 MAGI3_HUMAN 89.406 0.997967 0.996624 MAGI3 - Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 - Homo sapiens (Human) - MAGI3 gene Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. Taurus_UMD|evm.model.AC_000160.1.531 P30050 RL12_HUMAN 89.091 0.987578 0.975758 RPL12 - 60S ribosomal protein L12 - Homo sapiens (Human) - RPL12 gene Binds directly to 26S ribosomal RNA. Taurus_UMD|evm.model.AC_000160.1.532 O94898 LRIG2_HUMAN 91.831 0.998124 1.00094 LRIG2 - Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor - Homo sapiens (Human) - LRIG2 gene extracellular matrix, extracellular space Taurus_UMD|evm.model.AC_000160.1.533 Q3MHW6 MOT1_BOVIN 100.000 0.996016 1.002 SLC16A1 - Monocarboxylate transporter 1 - Bos taurus (Bovine) - SLC16A1 gene Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Taurus_UMD|evm.model.AC_000160.1.535 Q3MHW6 MOT1_BOVIN 76.707 0.993902 0.982036 SLC16A1 - Monocarboxylate transporter 1 - Bos taurus (Bovine) - SLC16A1 gene Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Taurus_UMD|evm.model.AC_000160.1.536 Q7TPG6 TAFA3_MOUSE 81.111 0.864078 0.780303 Tafa3 - Chemokine-like protein TAFA-3 precursor - Mus musculus (Mouse) - Tafa3 gene Plays a role in the regulation of microglia polarization. Taurus_UMD|evm.model.AC_000160.1.537 Q5JR12 PPM1J_HUMAN 94.074 0.729242 1.09703 PPM1J - Protein phosphatase 1J - Homo sapiens (Human) - PPM1J gene protein serine/threonine phosphatase activity, protein dephosphorylation Taurus_UMD|evm.model.AC_000160.1.538 Q5RCK9 RHOC_PONAB 100.000 0.989691 1.00518 RHOC - Rho-related GTP-binding protein RhoC precursor - Pongo abelii (Sumatran orangutan) - RHOC gene Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.539 Q0V8H6 MOV10_BOVIN 100.000 0.998008 1.001 MOV10 - Putative helicase MOV-10 - Bos taurus (Bovine) - MOV10 gene 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7 (By similarity). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (By similarity). Taurus_UMD|evm.model.AC_000160.1.540 A4FUA8 CAZA1_BOVIN 100.000 0.993031 1.0035 CAPZA1 - F-actin-capping protein subunit alpha-1 - Bos taurus (Bovine) - CAPZA1 gene F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. Taurus_UMD|evm.model.AC_000160.1.541 A3KN28 ST7L_BOVIN 100.000 0.996403 1.0018 ST7L - Suppressor of tumorigenicity 7 protein-like - Bos taurus (Bovine) - ST7L gene Taurus_UMD|evm.model.AC_000160.1.542 Q93097 WNT2B_HUMAN 97.208 0.994937 1.01023 WNT2B - Protein Wnt-2b precursor - Homo sapiens (Human) - WNT2B gene Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development. Taurus_UMD|evm.model.AC_000160.1.543 Q5RDH2 CT2NL_PONAB 92.175 0.996875 1.00156 CTTNBP2NL - CTTNBP2 N-terminal-like protein - Pongo abelii (Sumatran orangutan) - CTTNBP2NL gene Regulates lamellipodial actin dynamics in a CTTN-dependent manner. Taurus_UMD|evm.model.AC_000160.1.546 Q9UK17 KCND3_HUMAN 92.580 0.992453 0.40458 KCND3 - Potassium voltage-gated channel subfamily D member 3 - Homo sapiens (Human) - KCND3 gene Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Taurus_UMD|evm.model.AC_000160.1.547 Q9UHI6 DDX20_HUMAN 88.015 0.997579 1.00243 DDX20 - Probable ATP-dependent RNA helicase DDX20 - Homo sapiens (Human) - DDX20 gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). Taurus_UMD|evm.model.AC_000160.1.548 A6QP24 INKA2_BOVIN 100.000 0.99322 1.0034 INKA2 - PAK4-inhibitor INKA2 - Bos taurus (Bovine) - INKA2 gene Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity. Taurus_UMD|evm.model.AC_000160.1.549 P62836 RAP1A_RAT 89.674 0.987952 0.902174 Rap1a - Ras-related protein Rap-1A precursor - Rattus norvegicus (Rat) - Rap1a gene Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. Taurus_UMD|evm.model.AC_000160.1.550 Q0VC81 AA3R_BOVIN 93.750 0.368116 1.08833 ADORA3 - Adenosine receptor A3 - Bos taurus (Bovine) - ADORA3 gene Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Taurus_UMD|evm.model.AC_000160.1.551 Q3U7U4 CA162_MOUSE 58.261 0.55665 1.53788 Transmembrane protein C1orf162 homolog - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000160.1.552 P13619 AT5F1_BOVIN 100.000 0.992218 1.00391 ATP5PB - ATP synthase F(0) complex subunit B1, mitochondrial precursor - Bos taurus (Bovine) - ATP5PB gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Taurus_UMD|evm.model.AC_000160.1.553 Q5E9I7 MEP50_BOVIN 99.708 0.994169 1.00292 WDR77 - Methylosome protein 50 - Bos taurus (Bovine) - WDR77 gene Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Taurus_UMD|evm.model.AC_000160.1.554 Q28042 OVGP1_BOVIN 99.814 0.990758 1.00745 OVGP1 - Oviduct-specific glycoprotein precursor - Bos taurus (Bovine) - OVGP1 gene Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development. Taurus_UMD|evm.model.AC_000160.1.555 Q689Z7 PEPB_MONDO 58.647 0.84507 0.726343 PGB - Pepsin B precursor - Monodelphis domestica (Gray short-tailed opossum) - PGB gene Hydrolyzes various peptides including beta-endorphin, insulin B chain, dynorphin A, and neurokinin A, with high specificity for the cleavage of the Phe-Xaa bonds. Taurus_UMD|evm.model.AC_000160.1.557 Q6RY07 CHIA_RAT 48.770 0.990521 0.892178 Chia - Acidic mammalian chitinase precursor - Rattus norvegicus (Rat) - Chia gene Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding (By similarity). Taurus_UMD|evm.model.AC_000160.1.558 Q2TBS4 PIFO_BOVIN 77.957 0.755102 1.27604 PIFO - Protein pitchfork - Bos taurus (Bovine) - PIFO gene During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000160.1.559 Q95M17 CHIA_BOVIN 99.455 0.955614 0.811441 CHIA - Acidic mammalian chitinase precursor - Bos taurus (Bovine) - CHIA gene Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding (By similarity). Taurus_UMD|evm.model.AC_000160.1.560 Q95M17 CHIA_BOVIN 100.000 0.77037 0.286017 CHIA - Acidic mammalian chitinase precursor - Bos taurus (Bovine) - CHIA gene Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding (By similarity). Taurus_UMD|evm.model.AC_000160.1.561 Q9BZP6 CHIA_HUMAN 33.103 0.689189 0.310924 CHIA - Acidic mammalian chitinase precursor - Homo sapiens (Human) - CHIA gene Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. Taurus_UMD|evm.model.AC_000160.1.562 Q15782 CH3L2_HUMAN 88.205 0.762745 1.30769 CHI3L2 - Chitinase-3-like protein 2 precursor - Homo sapiens (Human) - CHI3L2 gene Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity. Taurus_UMD|evm.model.AC_000160.1.563 Q9H6A0 DEN2D_HUMAN 87.473 0.995736 0.995754 DENND2D - DENN domain-containing protein 2D - Homo sapiens (Human) - DENND2D gene Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Taurus_UMD|evm.model.AC_000160.1.564 Q9Y6K0 CEPT1_HUMAN 95.673 0.995204 1.0024 CEPT1 - Choline/ethanolaminephosphotransferase 1 - Homo sapiens (Human) - CEPT1 gene Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity. Taurus_UMD|evm.model.AC_000160.1.565 Q3ZC48 DRAM2_BOVIN 100.000 0.992509 1.00376 DRAM2 - DNA damage-regulated autophagy modulator protein 2 - Bos taurus (Bovine) - DRAM2 gene Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1. Taurus_UMD|evm.model.AC_000160.1.566 Q5T3J3 LRIF1_HUMAN 83.290 0.997403 1.0013 LRIF1 - Ligand-dependent nuclear receptor-interacting factor 1 - Homo sapiens (Human) - LRIF1 gene Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211). Taurus_UMD|evm.model.AC_000160.1.567 Q58DM3 CD53_BOVIN 100.000 0.990909 1.00457 CD53 - Leukocyte surface antigen CD53 - Bos taurus (Bovine) - CD53 gene Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.568 P16390 KCNA3_MOUSE 96.402 0.906412 1.0928 Kcna3 - Potassium voltage-gated channel subfamily A member 3 - Mus musculus (Mouse) - Kcna3 gene Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Taurus_UMD|evm.model.AC_000160.1.569 P16389 KCNA2_HUMAN 100.000 0.996 1.002 KCNA2 - Potassium voltage-gated channel subfamily A member 2 - Homo sapiens (Human) - KCNA2 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559, PubMed:11211111, PubMed:23769686). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559, PubMed:20220134). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:23769686). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:8495559). Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials (By similarity). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (By similarity). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (By similarity). Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (By similarity). Contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (By similarity). Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity). Taurus_UMD|evm.model.AC_000160.1.571 Q16322 KCA10_HUMAN 94.129 0.996094 1.00196 KCNA10 - Potassium voltage-gated channel subfamily A member 10 - Homo sapiens (Human) - KCNA10 gene Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP. Taurus_UMD|evm.model.AC_000160.1.572 P00794 CHYM_BOVIN 100.000 0.994764 1.00262 CYM - Chymosin precursor - Bos taurus (Bovine) - CYM gene Chymosin is synthesized in the mucosa of the abomasum (fourth stomach) of young (unweaned) ruminants. The enzyme hydrolyzes casein to paracasein. Taurus_UMD|evm.model.AC_000160.1.573 P58294 PROK1_HUMAN 87.619 0.981132 1.00952 PROK1 - Prokineticin-1 precursor - Homo sapiens (Human) - PROK1 gene Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. Taurus_UMD|evm.model.AC_000160.1.574 O15374 MOT5_HUMAN 83.707 0.972056 1.02875 SLC16A4 - Monocarboxylate transporter 5 - Homo sapiens (Human) - SLC16A4 gene Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). Taurus_UMD|evm.model.AC_000160.1.575 Q96T37 RBM15_HUMAN 97.382 0.990654 0.98567 RBM15 - RNA-binding protein 15 - Homo sapiens (Human) - RBM15 gene RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). Taurus_UMD|evm.model.AC_000160.1.576 Q63734 KCNC4_RAT 97.694 0.952532 1.0112 Kcnc4 - Potassium voltage-gated channel subfamily C member 4 - Rattus norvegicus (Rat) - Kcnc4 gene This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Taurus_UMD|evm.model.AC_000160.1.577 Q9H1V8 S6A17_HUMAN 85.282 0.996875 0.88033 SLC6A17 - Sodium-dependent neutral amino acid transporter SLC6A17 - Homo sapiens (Human) - SLC6A17 gene Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity). Taurus_UMD|evm.model.AC_000160.1.579 Q2T9Q2 UBL4B_BOVIN 100.000 0.987952 1.00606 UBL4B - Ubiquitin-like protein 4B - Bos taurus (Bovine) - UBL4B gene Taurus_UMD|evm.model.AC_000160.1.580 O95076 ALX3_HUMAN 91.254 0.994186 1.00292 ALX3 - Homeobox protein aristaless-like 3 - Homo sapiens (Human) - ALX3 gene Transcriptional regulator with a possible role in patterning of mesoderm during development. Taurus_UMD|evm.model.AC_000160.1.581 Q0P5J8 STRP1_BOVIN 100.000 0.997613 1.00119 STRIP1 - Striatin-interacting protein 1 - Bos taurus (Bovine) - STRIP1 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (By similarity). Taurus_UMD|evm.model.AC_000160.1.582 Q80SW1 SAHH2_MOUSE 100.000 0.99619 0.990566 Ahcyl1 - S-adenosylhomocysteine hydrolase-like protein 1 - Mus musculus (Mouse) - Ahcyl1 gene Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (By similarity). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (By similarity). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (By similarity). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (PubMed:12525476, PubMed:23542070). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:19224921). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (PubMed:19033647, PubMed:21317537). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2. Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition. May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state. Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (By similarity). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (PubMed:12525476). Taurus_UMD|evm.model.AC_000160.1.583 P09603 CSF1_HUMAN 74.354 0.820669 1.18773 CSF1 - Macrophage colony-stimulating factor 1 precursor - Homo sapiens (Human) - CSF1 gene Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. Taurus_UMD|evm.model.AC_000160.1.584 Q8TE67 ES8L3_HUMAN 72.481 0.868243 0.499157 EPS8L3 - Epidermal growth factor receptor kinase substrate 8-like protein 3 - Homo sapiens (Human) - EPS8L3 gene cytoplasm, plasma membrane, ruffle membrane, actin binding, positive regulation of ruffle assembly, regulation of hair cycle, regulation of Rho protein signal transduction, Rho protein signal transduction Taurus_UMD|evm.model.AC_000160.1.585 Q8TE67 ES8L3_HUMAN 68.333 0.7 0.286678 EPS8L3 - Epidermal growth factor receptor kinase substrate 8-like protein 3 - Homo sapiens (Human) - EPS8L3 gene cytoplasm, plasma membrane, ruffle membrane, actin binding, positive regulation of ruffle assembly, regulation of hair cycle, regulation of Rho protein signal transduction, Rho protein signal transduction Taurus_UMD|evm.model.AC_000160.1.586 Q9Z1B2 GSTM5_RAT 89.163 0.990196 0.906667 Gstm5 - Glutathione S-transferase Mu 5 - Rattus norvegicus (Rat) - Gstm5 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Taurus_UMD|evm.model.AC_000160.1.587 Q9N0V4 GSTM1_BOVIN 88.073 0.990868 1.00459 GSTM1 - Glutathione S-transferase Mu 1 - Bos taurus (Bovine) - GSTM1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Protects against the thiol-mediated metal-catalyzed oxidative inactivation of enzymes. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers (By similarity). Taurus_UMD|evm.model.AC_000160.1.588 Q9N0V4 GSTM1_BOVIN 100.000 0.990868 1.00459 GSTM1 - Glutathione S-transferase Mu 1 - Bos taurus (Bovine) - GSTM1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Protects against the thiol-mediated metal-catalyzed oxidative inactivation of enzymes. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers (By similarity). Taurus_UMD|evm.model.AC_000160.1.589 Q9N0V4 GSTM1_BOVIN 97.706 0.990868 1.00459 GSTM1 - Glutathione S-transferase Mu 1 - Bos taurus (Bovine) - GSTM1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Protects against the thiol-mediated metal-catalyzed oxidative inactivation of enzymes. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers (By similarity). Taurus_UMD|evm.model.AC_000160.1.590 Q9N0V4 GSTM1_BOVIN 85.780 0.990868 1.00459 GSTM1 - Glutathione S-transferase Mu 1 - Bos taurus (Bovine) - GSTM1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Protects against the thiol-mediated metal-catalyzed oxidative inactivation of enzymes. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers (By similarity). Taurus_UMD|evm.model.AC_000160.1.591 P09488 GSTM1_HUMAN 85.780 0.990868 1.00459 GSTM1 - Glutathione S-transferase Mu 1 - Homo sapiens (Human) - GSTM1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Taurus_UMD|evm.model.AC_000160.1.592 Q01433 AMPD2_HUMAN 97.337 0.997582 0.940842 AMPD2 - AMP deaminase 2 - Homo sapiens (Human) - AMPD2 gene AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle. Taurus_UMD|evm.model.AC_000160.1.593 P04696 GNAT2_BOVIN 100.000 0.994366 1.00282 GNAT2 - Guanine nucleotide-binding protein G(t) subunit alpha-2 - Bos taurus (Bovine) - GNAT2 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. Taurus_UMD|evm.model.AC_000160.1.594 P08754 GNAI3_HUMAN 98.870 0.994366 1.00282 GNAI3 - Guanine nucleotide-binding protein G(i) subunit alpha-3 - Homo sapiens (Human) - GNAI3 gene Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). Taurus_UMD|evm.model.AC_000160.1.595 Q9BZJ8 GPR61_HUMAN 96.674 0.995575 1.00222 GPR61 - G-protein coupled receptor 61 - Homo sapiens (Human) - GPR61 gene Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). May be involved in the regulation of food intake and body weight (By similarity). Taurus_UMD|evm.model.AC_000160.1.596 Q86WK6 AMGO1_HUMAN 94.726 0.995951 1.00203 AMIGO1 - Amphoterin-induced protein 1 precursor - Homo sapiens (Human) - AMIGO1 gene Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Taurus_UMD|evm.model.AC_000160.1.597 Q8N8Q1 C56D1_HUMAN 93.886 0.991304 1.00437 CYB561D1 - Probable transmembrane reductase CYB561D1 - Homo sapiens (Human) - CYB561D1 gene Probable transmembrane reductase that may use ascorbate as an electron donor and transfer electrons across membranes to reduce monodehydro-L-ascorbate radical and iron cations Fe(3+) in another cellular compartment. Taurus_UMD|evm.model.AC_000160.1.598 Q5T6C5 AT7L2_HUMAN 86.296 0.974801 1.04432 ATXN7L2 - Ataxin-7-like protein 2 - Homo sapiens (Human) - ATXN7L2 gene Taurus_UMD|evm.model.AC_000160.1.599 O62646 SYPL2_RABIT 93.939 0.992453 1.00379 SYPL2 - Synaptophysin-like protein 2 - Oryctolagus cuniculus (Rabbit) - SYPL2 gene Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes. Taurus_UMD|evm.model.AC_000160.1.600 Q9Z2U1 PSA5_MOUSE 100.000 0.991736 1.00415 Psma5 - Proteasome subunit alpha type-5 - Mus musculus (Mouse) - Psma5 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Taurus_UMD|evm.model.AC_000160.1.601 Q99523 SORT_HUMAN 94.832 0.947548 1.05535 SORT1 - Sortilin precursor - Homo sapiens (Human) - SORT1 gene Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:16787399). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. Taurus_UMD|evm.model.AC_000160.1.602 Q29RJ9 PSRC1_BOVIN 99.688 0.47619 2.06135 PSRC1 - Proline/serine-rich coiled-coil protein 1 - Bos taurus (Bovine) - PSRC1 gene Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity). Taurus_UMD|evm.model.AC_000160.1.603 Q9HCU4 CELR2_HUMAN 95.621 0.999312 0.993842 CELSR2 - Cadherin EGF LAG seven-pass G-type receptor 2 precursor - Homo sapiens (Human) - CELSR2 gene Receptor that may have an important role in cell/cell signaling during nervous system formation. Taurus_UMD|evm.model.AC_000160.1.604 Q9GMB8 SYSC_BOVIN 100.000 0.996117 1.00195 SARS1 - Serine--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - SARS1 gene Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA. Taurus_UMD|evm.model.AC_000160.1.605 Q6UXG2 ELAP1_HUMAN 92.892 0.998028 1.00099 ELAPOR1 - Endosome/lysosome-associated apoptosis and autophagy regulator 1 precursor - Homo sapiens (Human) - ELAPOR1 gene May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway (PubMed:21072319). May play a role in apoptosis and cell proliferation through its interaction with HSPA5 (PubMed:26045166). Taurus_UMD|evm.model.AC_000160.1.606 Q5T5A4 CA194_HUMAN 83.529 0.988304 1.01183 C1orf194 - Protein C1orf194 - Homo sapiens (Human) - C1orf194 gene May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis (PubMed:31199454). Taurus_UMD|evm.model.AC_000160.1.607 Q80X45 KISHB_MOUSE 100.000 0.973333 1.01351 Tmem167b - Protein kish-B precursor - Mus musculus (Mouse) - Tmem167b gene Involved in the early part of the secretory pathway. Taurus_UMD|evm.model.AC_000160.1.608 Q5R9W6 TAF13_PONAB 100.000 0.984 1.00806 TAF13 - Transcription initiation factor TFIID subunit 13 - Pongo abelii (Sumatran orangutan) - TAF13 gene Component of the DNA-binding general RNA polymerase II transcription factor IID complex (TFIID). TFIID plays a critical role in the regulation of gene transcription in eukaryotic cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.609 Q9H246 CA021_HUMAN 92.537 0.88 0.619835 C1orf21 - Uncharacterized protein C1orf21 - Homo sapiens (Human) - C1orf21 gene Taurus_UMD|evm.model.AC_000160.1.610 O94967 WDR47_HUMAN 97.171 0.997826 1.00109 WDR47 - WD repeat-containing protein 47 - Homo sapiens (Human) - WDR47 gene Taurus_UMD|evm.model.AC_000160.1.611 Q1LZF8 CLCC1_BOVIN 100.000 0.996317 1.00185 CLCC1 - Chloride channel CLIC-like protein 1 precursor - Bos taurus (Bovine) - CLCC1 gene Seems to act as a chloride ion channel (By similarity). Plays a role in retina development (By similarity). Taurus_UMD|evm.model.AC_000160.1.612 P81274 GPSM2_HUMAN 93.833 0.997067 0.997076 GPSM2 - G-protein-signaling modulator 2 - Homo sapiens (Human) - GPSM2 gene Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays also an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity). Taurus_UMD|evm.model.AC_000160.1.613 Q8WP21 AKND1_MACFA 63.813 0.718927 0.932806 AKNAD1 - Protein AKNAD1 - Macaca fascicularis (Crab-eating macaque) - AKNAD1 gene Taurus_UMD|evm.model.AC_000160.1.614 O00186 STXB3_HUMAN 94.257 0.454266 2.19764 STXBP3 - Syntaxin-binding protein 3 - Homo sapiens (Human) - STXBP3 gene Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. Taurus_UMD|evm.model.AC_000160.1.615 Q5VTL7 FNDC7_HUMAN 85.965 0.986111 0.392906 FNDC7 - Fibronectin type III domain-containing protein 7 precursor - Homo sapiens (Human) - FNDC7 gene Taurus_UMD|evm.model.AC_000160.1.616 Q5VTL8 PR38B_HUMAN 96.154 0.996324 0.996337 PRPF38B - Pre-mRNA-splicing factor 38B - Homo sapiens (Human) - PRPF38B gene May be required for pre-mRNA splicing. Taurus_UMD|evm.model.AC_000160.1.617 Q4R3W5 HENMT_MACFA 60.313 0.84 1.14504 HENMT1 - Small RNA 2'-O-methyltransferase - Macaca fascicularis (Crab-eating macaque) - HENMT1 gene Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. Taurus_UMD|evm.model.AC_000160.1.618 Q5T8I3 F102B_HUMAN 94.444 0.991713 1.00556 FAM102B - Protein FAM102B - Homo sapiens (Human) - FAM102B gene Taurus_UMD|evm.model.AC_000160.1.619 O18757 SCMC1_RABIT 50.541 0.942529 0.732632 SLC25A24 - Calcium-binding mitochondrial carrier protein SCaMC-1 - Oryctolagus cuniculus (Rabbit) - SLC25A24 gene Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix (By similarity). Taurus_UMD|evm.model.AC_000160.1.620 A5PJZ1 SCMC1_BOVIN 50.000 0.995475 0.926625 SLC25A24 - Calcium-binding mitochondrial carrier protein SCaMC-1 - Bos taurus (Bovine) - SLC25A24 gene Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity). Taurus_UMD|evm.model.AC_000160.1.621 A5PJZ1 SCMC1_BOVIN 89.308 0.995338 0.899371 SLC25A24 - Calcium-binding mitochondrial carrier protein SCaMC-1 - Bos taurus (Bovine) - SLC25A24 gene Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity). Taurus_UMD|evm.model.AC_000160.1.622 Q9UKW4 VAV3_HUMAN 96.104 0.890526 1.12161 VAV3 - Guanine nucleotide exchange factor VAV3 - Homo sapiens (Human) - VAV3 gene Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity). Taurus_UMD|evm.model.AC_000160.1.623 Q9Z0R6 ITSN2_MOUSE 95.014 0.897756 0.241712 Itsn2 - Intersectin-2 - Mus musculus (Mouse) - Itsn2 gene Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. Taurus_UMD|evm.model.AC_000160.1.625 Q5E9L5 ANM6_BOVIN 100.000 0.994681 1.00267 PRMT6 - Protein arginine N-methyltransferase 6 - Bos taurus (Bovine) - PRMT6 gene Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (By similarity). Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. Methylates GPS2, protecting GPS2 from ubiquitination and degradation. Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (By similarity). Taurus_UMD|evm.model.AC_000160.1.626 P18203 FKB1A_BOVIN 97.222 0.981651 1.00926 FKBP1A - Peptidyl-prolyl cis-trans isomerase FKBP1A - Bos taurus (Bovine) - FKBP1A gene Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Taurus_UMD|evm.model.AC_000160.1.628 D4AAZ6 RL37A_RAT 60.656 0.980392 0.708333 Rpl37a - 60S ribosomal protein L37a - Rattus norvegicus (Rat) - Rpl37a gene cytosolic large ribosomal subunit, large ribosomal subunit rRNA binding Taurus_UMD|evm.model.AC_000160.1.629 P81134 RENR_BOVIN 86.957 0.926829 0.350427 ATP6AP2 - Renin receptor precursor - Bos taurus (Bovine) - ATP6AP2 gene Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (v-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (By similarity). Involved in many neuronal processes including synapse morphology and synaptic transmission (By similarity). Taurus_UMD|evm.model.AC_000160.1.631 P19961 AMY2B_HUMAN 88.454 0.996094 1.00196 AMY2B - Alpha-amylase 2B precursor - Homo sapiens (Human) - AMY2B gene extracellular exosome, alpha-amylase activity Taurus_UMD|evm.model.AC_000160.1.632 P19961 AMY2B_HUMAN 86.497 0.996094 1.00196 AMY2B - Alpha-amylase 2B precursor - Homo sapiens (Human) - AMY2B gene extracellular exosome, alpha-amylase activity Taurus_UMD|evm.model.AC_000160.1.633 Q3MHP0 RNPC3_BOVIN 99.613 0.996139 1.00388 RNPC3 - RNA-binding region-containing protein 3 - Bos taurus (Bovine) - RNPC3 gene Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA (By similarity). Taurus_UMD|evm.model.AC_000160.1.634 Q2KIU7 RSPH9_BOVIN 99.301 0.898734 0.572464 RSPH9 - Radial spoke head protein 9 homolog - Bos taurus (Bovine) - RSPH9 gene Component of the axonemal radial spoke head which plays an important role in ciliary motility (By similarity). Essential for both the radial spoke head assembly and the central pair microtubule stability in ependymal motile cilia (By similarity). Required for motility of olfactory and neural cilia and for the structural integrity of ciliary axonemes in both 9+0 and 9+2 motile cilia (By similarity). Taurus_UMD|evm.model.AC_000160.1.636 P12107 COBA1_HUMAN 93.140 0.998695 0.848283 COL11A1 - Collagen alpha-1(XI) chain precursor - Homo sapiens (Human) - COL11A1 gene May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. Taurus_UMD|evm.model.AC_000160.1.637 Q3ZBM4 ITBP1_BOVIN 81.481 0.908046 0.435 ITGB1BP1 - Integrin beta-1-binding protein 1 - Bos taurus (Bovine) - ITGB1BP1 gene Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter (By similarity). Taurus_UMD|evm.model.AC_000160.1.638 P68105 EF1A1_RABIT 77.987 0.953177 0.647186 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000160.1.639 P63057 NOE3_RAT 94.839 0.995643 0.960251 Olfm3 - Noelin-3 precursor - Rattus norvegicus (Rat) - Olfm3 gene AMPA glutamate receptor complex, extracellular space, Golgi apparatus, eye photoreceptor cell development Taurus_UMD|evm.model.AC_000160.1.640 Q5E9P3 S1PR1_BOVIN 100.000 0.994778 1.00262 S1PR1 - Sphingosine 1-phosphate receptor 1 - Bos taurus (Bovine) - S1PR1 gene G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury (By similarity). Taurus_UMD|evm.model.AC_000160.1.641 Q5E982 DPH5_BOVIN 100.000 0.993007 1.00351 DPH5 - Diphthine methyl ester synthase - Bos taurus (Bovine) - DPH5 gene S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. Taurus_UMD|evm.model.AC_000160.1.642 A4IFD7 ZNT7_BOVIN 100.000 0.216949 0.784574 SLC30A7 - Zinc transporter 7 - Bos taurus (Bovine) - SLC30A7 gene Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity). Taurus_UMD|evm.model.AC_000160.1.643 Q9ES89 EXTL2_MOUSE 87.879 0.993958 1.00303 Extl2 - Exostosin-like 2 - Mus musculus (Mouse) - Extl2 gene Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Taurus_UMD|evm.model.AC_000160.1.644 Q28260 VCAM1_CANLF 78.019 0.994595 1.00135 VCAM1 - Vascular cell adhesion protein 1 precursor - Canis lupus familiaris (Dog) - VCAM1 gene Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation (By similarity). Taurus_UMD|evm.model.AC_000160.1.645 Q28260 VCAM1_CANLF 77.568 0.997301 1.00271 VCAM1 - Vascular cell adhesion protein 1 precursor - Canis lupus familiaris (Dog) - VCAM1 gene Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation (By similarity). Taurus_UMD|evm.model.AC_000160.1.646 Q9GZN0 GPR88_HUMAN 97.135 0.994792 1 GPR88 - Probable G-protein coupled receptor 88 - Homo sapiens (Human) - GPR88 gene Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function. Taurus_UMD|evm.model.AC_000160.1.647 Q9UNH5 CC14A_HUMAN 93.289 0.99665 1.00505 CDC14A - Dual specificity protein phosphatase CDC14A - Homo sapiens (Human) - CDC14A gene Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). Taurus_UMD|evm.model.AC_000160.1.648 P63159 HMGB1_RAT 85.093 0.952096 0.776744 Hmgb1 - High mobility group protein B1 - Rattus norvegicus (Rat) - Hmgb1 gene Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide (PubMed:11154118). Bound to RAGE mediates signaling for neuronal outgrowth (PubMed:1885601, PubMed:2461949, PubMed:7592757, PubMed:12183440). May play a role in accumulation of expanded polyglutamine (polyQ) proteins. Taurus_UMD|evm.model.AC_000160.1.650 Q2HJ88 RTCA_BOVIN 100.000 0.99455 1.00273 RTCA - RNA 3'-terminal phosphate cyclase - Bos taurus (Bovine) - RTCA gene Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity). Taurus_UMD|evm.model.AC_000160.1.651 P11181 ODB2_BOVIN 100.000 0.995859 1.00207 DBT - Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor - Bos taurus (Bovine) - DBT gene The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component. Taurus_UMD|evm.model.AC_000160.1.652 Q5XGD9 ARI3A_XENTR 59.547 0.6 0.804067 arid3a - AT-rich interactive domain-containing protein 3A - Xenopus tropicalis (Western clawed frog) - arid3a gene Transcription factor required for smad1 and smad2-mediated responses to TGFbeta during mesoderm induction. Taurus_UMD|evm.model.AC_000160.1.653 Q3ZC49 LRC39_BOVIN 100.000 0.99403 1.00299 LRRC39 - Leucine-rich repeat-containing protein 39 - Bos taurus (Bovine) - LRRC39 gene Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart. Taurus_UMD|evm.model.AC_000160.1.654 Q9NUP7 TRM13_HUMAN 90.644 0.995851 1.00208 TRMT13 - tRNA:m(4)X modification enzyme TRM13 homolog - Homo sapiens (Human) - TRMT13 gene tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). Taurus_UMD|evm.model.AC_000160.1.655 Q6UVJ0 SAS6_HUMAN 92.237 0.99696 1.00152 SASS6 - Spindle assembly abnormal protein 6 homolog - Homo sapiens (Human) - SASS6 gene Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124). Taurus_UMD|evm.model.AC_000160.1.656 P70187 MF14A_MOUSE 99.796 0.995927 1.00204 Mfsd14a - Hippocampus abundant transcript 1 protein - Mus musculus (Mouse) - Mfsd14a gene acrosome assembly, sperm mitochondrion organization, spermatid development, spermatid nucleus differentiation, spermatogenesis Taurus_UMD|evm.model.AC_000160.1.657 Q6YC49 S35A3_BOVIN 100.000 0.766509 1.30061 SLC35A3 - UDP-N-acetylglucosamine transporter - Bos taurus (Bovine) - SLC35A3 gene Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides (By similarity). Taurus_UMD|evm.model.AC_000160.1.658 Q2PQH8 GDE_CANLF 93.216 0.998695 1 AGL - Glycogen debranching enzyme - Canis lupus familiaris (Dog) - AGL gene Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. Taurus_UMD|evm.model.AC_000160.1.659 A2VE04 FRRS1_BOVIN 99.605 0.958175 0.445008 FRRS1 - Ferric-chelate reductase 1 - Bos taurus (Bovine) - FRRS1 gene Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Taurus_UMD|evm.model.AC_000160.1.660 A2VE04 FRRS1_BOVIN 100.000 0.993355 0.509306 FRRS1 - Ferric-chelate reductase 1 - Bos taurus (Bovine) - FRRS1 gene Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Taurus_UMD|evm.model.AC_000160.1.661 Q3MHH7 PALMD_BOVIN 99.636 0.99637 1.00182 PALMD - Palmdelphin - Bos taurus (Bovine) - PALMD gene cytoplasm Taurus_UMD|evm.model.AC_000160.1.662 Q7Z2D5 PLPR4_HUMAN 97.765 0.997211 0.939712 PLPPR4 - 2-lysophosphatidate phosphatase PLPPR4 - Homo sapiens (Human) - PLPPR4 gene Hydrolyzes lysophosphatidic acid (LPA) and participates to the axonal outgrowth during development by attenuating phospholipid-induced axon collapse in neuron. Taurus_UMD|evm.model.AC_000160.1.663 Q32ZL2 PLPR5_HUMAN 98.131 0.993789 1.00312 PLPPR5 - Phospholipid phosphatase-related protein type 5 - Homo sapiens (Human) - PLPPR5 gene Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction. Taurus_UMD|evm.model.AC_000160.1.664 Q9UNH6 SNX7_HUMAN 94.301 0.85177 1.16796 SNX7 - Sorting nexin-7 - Homo sapiens (Human) - SNX7 gene May be involved in several stages of intracellular trafficking. Taurus_UMD|evm.model.AC_000160.1.665 Q95KF9 NO40_MACFA 84.000 0.827586 0.300518 ZCCHC17 - Nucleolar protein of 40 kDa - Macaca fascicularis (Crab-eating macaque) - ZCCHC17 gene Taurus_UMD|evm.model.AC_000160.1.666 Q28007 DPYD_BOVIN 100.000 0.855556 0.0878049 DPYD - Dihydropyrimidine dehydrogenase [NADP(+)] - Bos taurus (Bovine) - DPYD gene Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Taurus_UMD|evm.model.AC_000160.1.667 Q28007 DPYD_BOVIN 99.460 0.997305 0.723902 DPYD - Dihydropyrimidine dehydrogenase [NADP(+)] - Bos taurus (Bovine) - DPYD gene Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Taurus_UMD|evm.model.AC_000160.1.668 Q9UKA9 PTBP2_HUMAN 85.743 0.995402 0.819209 PTBP2 - Polypyrimidine tract-binding protein 2 - Homo sapiens (Human) - PTBP2 gene RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. Taurus_UMD|evm.model.AC_000160.1.670 A3KN24 RWDD3_BOVIN 100.000 0.992537 1.00375 RWDD3 - RWD domain-containing protein 3 - Bos taurus (Bovine) - RWDD3 gene Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the: binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Negatively regulates the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Has no effect on ubiquitination (By similarity). Taurus_UMD|evm.model.AC_000160.1.671 Q96MV1 TLCD4_HUMAN 61.392 0.968504 0.48289 TLCD4 - TLC domain-containing protein 4 - Homo sapiens (Human) - TLCD4 gene endoplasmic reticulum, lipid homeostasis Taurus_UMD|evm.model.AC_000160.1.673 Q96F25 ALG14_HUMAN 81.500 0.912844 1.00926 ALG14 - UDP-N-acetylglucosamine transferase subunit ALG14 homolog - Homo sapiens (Human) - ALG14 gene May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER. Taurus_UMD|evm.model.AC_000160.1.674 Q32L92 CNN3_BOVIN 100.000 0.993939 1.00304 CNN3 - Calponin-3 - Bos taurus (Bovine) - CNN3 gene Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). Taurus_UMD|evm.model.AC_000160.1.675 A5PK40 CTL3_BOVIN 86.997 0.949838 0.952234 SLC44A3 - Choline transporter-like protein 3 - Bos taurus (Bovine) - SLC44A3 gene membrane, transmembrane transporter activity, transmembrane transport Taurus_UMD|evm.model.AC_000160.1.676 P30931 TF_BOVIN 100.000 0.993174 1.00342 F3 - Tissue factor precursor - Bos taurus (Bovine) - F3 gene Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Taurus_UMD|evm.model.AC_000160.1.677 P28288 ABCD3_HUMAN 94.385 0.996956 0.996965 ABCD3 - ATP-binding cassette sub-family D member 3 - Homo sapiens (Human) - ABCD3 gene Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis (PubMed:25168382). The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity (PubMed:11248239). Taurus_UMD|evm.model.AC_000160.1.678 A7YY57 RHG29_BOVIN 100.000 0.998425 1.00079 ARHGAP29 - Rho GTPase-activating protein 29 - Bos taurus (Bovine) - ARHGAP29 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis (By similarity). Taurus_UMD|evm.model.AC_000160.1.679 P78363 ABCA4_HUMAN 87.984 0.941548 1.04619 ABCA4 - Retinal-specific phospholipid-transporting ATPase ABCA4 - Homo sapiens (Human) - ABCA4 gene Catalyzes the translocation of specific phospholipids from the extracellular/lumenal to the cytoplasmic leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylethanolamine (PubMed:24097981). In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery. Taurus_UMD|evm.model.AC_000160.1.680 Q2T9Y6 GSH0_BOVIN 100.000 0.992727 1.00365 GCLM - Glutamate--cysteine ligase regulatory subunit - Bos taurus (Bovine) - GCLM gene glutamate-cysteine ligase complex, enzyme regulator activity, glutamate-cysteine ligase catalytic subunit binding, blood vessel diameter maintenance, glutamate metabolic process, glutathione biosynthetic process, positive regulation of glutamate-cysteine ligase activity, response to drug, response to oxidative stress Taurus_UMD|evm.model.AC_000160.1.681 Q0P5H2 TDIF2_BOVIN 100.000 0.997392 1.00131 DNTTIP2 - Deoxynucleotidyltransferase terminal-interacting protein 2 - Bos taurus (Bovine) - DNTTIP2 gene Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (By similarity). Taurus_UMD|evm.model.AC_000160.1.682 Q58DL5 BCAR3_BOVIN 99.879 0.967175 1.03269 BCAR3 - Breast cancer anti-estrogen resistance protein 3 homolog - Bos taurus (Bovine) - BCAR3 gene Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (By similarity). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity. May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (By similarity). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling. Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA. Positively regulates integrin-induced tyrosine phosphorylation of BCAR1. Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (By similarity). Taurus_UMD|evm.model.AC_000160.1.683 Q2HWF0 FBP1L_RAT 87.769 0.99635 0.905785 Fnbp1l - Formin-binding protein 1-like - Rattus norvegicus (Rat) - Fnbp1l gene Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens (By similarity). May negatively regulate neurite extension and axon branching in developing neurons. Taurus_UMD|evm.model.AC_000160.1.684 Q01658 NC2B_HUMAN 100.000 0.988701 1.00568 DR1 - Protein Dr1 - Homo sapiens (Human) - DR1 gene The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Taurus_UMD|evm.model.AC_000160.1.686 Q5E9E2 MYL9_BOVIN 58.451 0.978261 0.534884 MYL9 - Myosin regulatory light polypeptide 9 - Bos taurus (Bovine) - MYL9 gene Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity). Taurus_UMD|evm.model.AC_000160.1.687 Q5T9S5 CCD18_HUMAN 89.890 0.971888 1.02751 CCDC18 - Coiled-coil domain-containing protein 18 - Homo sapiens (Human) - CCDC18 gene Taurus_UMD|evm.model.AC_000160.1.688 Q2KJ84 TMED5_BOVIN 100.000 0.991189 1.00442 TMED5 - Transmembrane emp24 domain-containing protein 5 precursor - Bos taurus (Bovine) - TMED5 gene Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity). Taurus_UMD|evm.model.AC_000160.1.689 Q5R7T9 MTF2_PONAB 99.325 0.996633 1.00169 MTF2 - Metal-response element-binding transcription factor 2 - Pongo abelii (Sumatran orangutan) - MTF2 gene Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (By similarity). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). Taurus_UMD|evm.model.AC_000160.1.690 Q5R634 DIK1A_PONAB 100.000 0.981132 0.866822 DIPK1A - Divergent protein kinase domain 1A - Pongo abelii (Sumatran orangutan) - DIPK1A gene Taurus_UMD|evm.model.AC_000160.1.691 Q58DW5 RL5_BOVIN 100.000 0.732997 1.3367 RPL5 - 60S ribosomal protein L5 - Bos taurus (Bovine) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Taurus_UMD|evm.model.AC_000160.1.692 Q96CN4 EVI5L_HUMAN 70.281 0.946731 1.0403 EVI5L - EVI5-like protein - Homo sapiens (Human) - EVI5L gene Functions as a GTPase-activating protein (GAP) with a broad specificity. Taurus_UMD|evm.model.AC_000160.1.693 Q5DWN0 GFI1_CANLF 95.261 0.995249 0.99763 GFI1 - Zinc finger protein Gfi-1 - Canis lupus familiaris (Dog) - GFI1 gene Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.694 F6RRD7 RPAP2_BOVIN 100.000 0.996716 1.00164 RPAP2 - Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 - Bos taurus (Bovine) - RPAP2 gene Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. Taurus_UMD|evm.model.AC_000160.1.695 Q92990 GLMN_HUMAN 89.545 0.996627 0.998316 GLMN - Glomulin - Homo sapiens (Human) - GLMN gene Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924). Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924). Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature (PubMed:11845407). Contributes to the regulation of RPS6KB1 phosphorylation (PubMed:11571281). Taurus_UMD|evm.model.AC_000160.1.696 Q2TA05 SPO16_BOVIN 100.000 0.989011 1.00552 SPO16 - Protein SPO16 homolog - Bos taurus (Bovine) - SPO16 gene Plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC) thereby stabilizing SC, ensuring progression of meiotic prophase I in male and female germ cells (By similarity). Promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1 (By similarity). Required for the localization of TEX11 and MSH4 to recombination intermediates (By similarity). Taurus_UMD|evm.model.AC_000160.1.697 Q5XKL5 BTBD8_HUMAN 81.137 0.214008 4.75926 BTBD8 - BTB/POZ domain-containing protein 8 - Homo sapiens (Human) - BTBD8 gene nucleoplasm Taurus_UMD|evm.model.AC_000160.1.698 Q9D5U0 PCT2B_MOUSE 76.660 0.831933 1.1531 Lpcat2b - Lysophosphatidylcholine acyltransferase 2B - Mus musculus (Mouse) - Lpcat2b gene Probable acetyltransferase. Taurus_UMD|evm.model.AC_000160.1.699 Q8IUS5 EPHX4_HUMAN 92.818 0.99449 1.00276 EPHX4 - Epoxide hydrolase 4 - Homo sapiens (Human) - EPHX4 gene hydrolase activity Taurus_UMD|evm.model.AC_000160.1.700 Q4R8Y1 BRDT_MACFA 81.408 0.992521 0.988384 BRDT - Bromodomain testis-specific protein - Macaca fascicularis (Crab-eating macaque) - BRDT gene Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin. Taurus_UMD|evm.model.AC_000160.1.701 Q03167 TGBR3_HUMAN 87.544 0.987194 1.0094 TGFBR3 - Transforming growth factor beta receptor type 3 precursor - Homo sapiens (Human) - TGFBR3 gene Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Taurus_UMD|evm.model.AC_000160.1.703 O00311 CDC7_HUMAN 89.062 0.840643 1.19164 CDC7 - Cell division cycle 7-related protein kinase - Homo sapiens (Human) - CDC7 gene Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylate MCM2 and MCM3. Taurus_UMD|evm.model.AC_000160.1.704 A2PYH4 HFM1_HUMAN 83.611 0.99858 0.981185 HFM1 - Probable ATP-dependent DNA helicase HFM1 - Homo sapiens (Human) - HFM1 gene Required for crossover formation and complete synapsis of homologous chromosomes during meiosis. Taurus_UMD|evm.model.AC_000160.1.705 P19483 ATPA_BOVIN 57.447 0.960526 0.274864 ATP5F1A - ATP synthase subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - ATP5F1A gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity). Taurus_UMD|evm.model.AC_000160.1.706 Q9H582 ZN644_HUMAN 92.540 0.998494 1.00075 ZNF644 - Zinc finger protein 644 - Homo sapiens (Human) - ZNF644 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000160.1.707 Q8VIB5 BARH2_MOUSE 94.226 0.994751 0.992188 Barhl2 - BarH-like 2 homeobox protein - Mus musculus (Mouse) - Barhl2 gene Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up-regulate NGN2, thereby regulating distinct patterns of neuronal differentiation (By similarity). Taurus_UMD|evm.model.AC_000160.1.711 F1MJM0 ZN326_BOVIN 100.000 0.996552 1.00173 ZNF326 - DBIRD complex subunit ZNF326 - Bos taurus (Bovine) - ZNF326 gene Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro (By similarity). Taurus_UMD|evm.model.AC_000160.1.712 Q7L1W4 LRC8D_HUMAN 97.086 0.753076 1.32634 LRRC8D - Volume-regulated anion channel subunit LRRC8D - Homo sapiens (Human) - LRRC8D gene Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:32415200). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309). Taurus_UMD|evm.model.AC_000160.1.713 A5PK13 LRC8C_BOVIN 100.000 0.997512 1.00125 LRRC8C - Volume-regulated anion channel subunit LRRC8C - Bos taurus (Bovine) - LRRC8C gene Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Taurus_UMD|evm.model.AC_000160.1.714 Q6P9F7 LRC8B_HUMAN 97.139 0.997516 1.00249 LRRC8B - Volume-regulated anion channel subunit LRRC8B - Homo sapiens (Human) - LRRC8B gene Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Taurus_UMD|evm.model.AC_000160.1.715 Q6ZN66 GBP6_HUMAN 75.478 0.99682 0.993681 GBP6 - Guanylate-binding protein 6 - Homo sapiens (Human) - GBP6 gene Binds GTP, GDP and GMP. Taurus_UMD|evm.model.AC_000160.1.717 Q6ZN66 GBP6_HUMAN 74.841 0.99682 0.993681 GBP6 - Guanylate-binding protein 6 - Homo sapiens (Human) - GBP6 gene Binds GTP, GDP and GMP. Taurus_UMD|evm.model.AC_000160.1.718 Q6ZN66 GBP6_HUMAN 72.195 0.499593 1.94155 GBP6 - Guanylate-binding protein 6 - Homo sapiens (Human) - GBP6 gene Binds GTP, GDP and GMP. Taurus_UMD|evm.model.AC_000160.1.719 Q5D1D6 GBP1_CHLAE 83.926 0.978441 1.02203 GBP1 - Guanylate-binding protein 1 precursor - Chlorocebus aethiops (Green monkey) - GBP1 gene Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). Taurus_UMD|evm.model.AC_000160.1.720 P32456 GBP2_HUMAN 78.261 0.235699 3.93401 GBP2 - Guanylate-binding protein 2 precursor - Homo sapiens (Human) - GBP2 gene Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). Taurus_UMD|evm.model.AC_000160.1.721 Q61107 GBP4_MOUSE 67.418 0.523203 1.77258 Gbp4 - Guanylate-binding protein 4 - Mus musculus (Mouse) - Gbp4 gene Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation. Taurus_UMD|evm.model.AC_000160.1.722 Q96PP9 GBP4_HUMAN 78.378 0.608333 0.1875 GBP4 - Guanylate-binding protein 4 - Homo sapiens (Human) - GBP4 gene Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity). Taurus_UMD|evm.model.AC_000160.1.723 Q8N8V2 GBP7_HUMAN 81.421 0.679104 0.420063 GBP7 - Guanylate-binding protein 7 - Homo sapiens (Human) - GBP7 gene Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). Taurus_UMD|evm.model.AC_000160.1.724 Q6ZN66 GBP6_HUMAN 82.775 0.152269 2.15798 GBP6 - Guanylate-binding protein 6 - Homo sapiens (Human) - GBP6 gene Binds GTP, GDP and GMP. Taurus_UMD|evm.model.AC_000160.1.725 Q5D1D6 GBP1_CHLAE 79.365 0.596154 0.176271 GBP1 - Guanylate-binding protein 1 precursor - Chlorocebus aethiops (Green monkey) - GBP1 gene Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). Taurus_UMD|evm.model.AC_000160.1.726 Q61107 GBP4_MOUSE 68.977 0.935065 0.993548 Gbp4 - Guanylate-binding protein 4 - Mus musculus (Mouse) - Gbp4 gene Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation. Taurus_UMD|evm.model.AC_000160.1.727 Q5D1D6 GBP1_CHLAE 84.642 0.349462 2.83729 GBP1 - Guanylate-binding protein 1 precursor - Chlorocebus aethiops (Green monkey) - GBP1 gene Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). Taurus_UMD|evm.model.AC_000160.1.728 Q0P5G4 KAT3_BOVIN 100.000 0.995614 1.0022 KYAT3 - Kynurenine--oxoglutarate transaminase 3 - Bos taurus (Bovine) - KYAT3 gene Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro). Taurus_UMD|evm.model.AC_000160.1.729 Q5R886 TF2B_PONAB 100.000 0.993691 1.00316 GTF2B - Transcription initiation factor IIB - Pongo abelii (Sumatran orangutan) - GTF2B gene General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Exhibits also autoacetyltransferase activity that contributes to the activated transcription. Taurus_UMD|evm.model.AC_000160.1.730 Q16513 PKN2_HUMAN 97.053 0.997963 0.997967 PKN2 - Serine/threonine-protein kinase N2 - Homo sapiens (Human) - PKN2 gene PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). Taurus_UMD|evm.model.AC_000160.1.732 Q7YR49 PO5F1_PANTR 75.000 0.672131 0.508333 POU5F1 - POU domain, class 5, transcription factor 1 - Pan troglodytes (Chimpanzee) - POU5F1 gene Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Taurus_UMD|evm.model.AC_000160.1.733 O97552 PO5F1_BOVIN 52.586 0.798077 0.288889 POU5F1 - POU domain, class 5, transcription factor 1 - Bos taurus (Bovine) - POU5F1 gene Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Taurus_UMD|evm.model.AC_000160.1.734 P61969 LMO4_MOUSE 100.000 0.987952 1.00606 Lmo4 - LIM domain transcription factor LMO4 - Mus musculus (Mouse) - Lmo4 gene Probable transcriptional factor. Taurus_UMD|evm.model.AC_000160.1.735 P38982 RSSA_CRIGR 79.365 0.626263 0.335593 Rpsa - 40S ribosomal protein SA - Cricetulus griseus (Chinese hamster) - Rpsa gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, Sindbis virus, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity). Taurus_UMD|evm.model.AC_000160.1.736 Q9D6Y1 CCDC3_MOUSE 71.111 0.4 0.40293 Ccdc3 - Coiled-coil domain-containing protein 3 precursor - Mus musculus (Mouse) - Ccdc3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (By similarity). Positively regulates lipid accumulation in adipose cells (PubMed:25605713). Taurus_UMD|evm.model.AC_000160.1.737 Q9UPS8 ANR26_HUMAN 73.973 0.517986 0.0812865 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000160.1.738 Q7LGA3 HS2ST_HUMAN 98.113 0.981424 0.907303 HS2ST1 - Heparan sulfate 2-O-sulfotransferase 1 - Homo sapiens (Human) - HS2ST1 gene Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). Taurus_UMD|evm.model.AC_000160.1.739 Q7LGA3 HS2ST_HUMAN 100.000 0.56338 0.199438 HS2ST1 - Heparan sulfate 2-O-sulfotransferase 1 - Homo sapiens (Human) - HS2ST1 gene Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). Taurus_UMD|evm.model.AC_000160.1.740 Q32P51 RA1L2_HUMAN 91.176 0.437908 0.478125 HNRNPA1L2 - Heterogeneous nuclear ribonucleoprotein A1-like 2 - Homo sapiens (Human) - HNRNPA1L2 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. Taurus_UMD|evm.model.AC_000160.1.741 Q0P5L0 RBM42_BOVIN 98.571 0.757246 0.616071 RBM42 - RNA-binding protein 42 - Bos taurus (Bovine) - RBM42 gene Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA. Taurus_UMD|evm.model.AC_000160.1.742 Q32LM0 SHLB1_BOVIN 89.488 0.966057 1.04932 SH3GLB1 - Endophilin-B1 - Bos taurus (Bovine) - SH3GLB1 gene May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Taurus_UMD|evm.model.AC_000160.1.743 P54281 CLCA1_BOVIN 99.668 0.997788 1.00111 Calcium-activated chloride channel regulator 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000160.1.744 P54281 CLCA1_BOVIN 88.496 0.996689 1.00332 Calcium-activated chloride channel regulator 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000160.1.745 Q14CN2 CLCA4_HUMAN 74.919 0.980728 1.01632 CLCA4 - Calcium-activated chloride channel regulator 4 precursor - Homo sapiens (Human) - CLCA4 gene May be involved in mediating calcium-activated chloride conductance. Taurus_UMD|evm.model.AC_000160.1.746 Q2TU62 CLCA1_HORSE 81.998 0.997778 0.985761 CLCA1 - Calcium-activated chloride channel regulator 1 precursor - Equus caballus (Horse) - CLCA1 gene May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC (By similarity). Taurus_UMD|evm.model.AC_000160.1.747 Q9UQC9 CLCA2_HUMAN 81.033 0.921283 1.0912 CLCA2 - Calcium-activated chloride channel regulator 2 precursor - Homo sapiens (Human) - CLCA2 gene Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. Taurus_UMD|evm.model.AC_000160.1.748 Q0VBY1 ODF2L_BOVIN 94.171 0.996317 0.990876 ODF2L - Protein BCAP - Bos taurus (Bovine) - ODF2L gene Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis. Taurus_UMD|evm.model.AC_000160.1.749 Q17RW2 COOA1_HUMAN 82.119 0.981788 0.704784 COL24A1 - Collagen alpha-1(XXIV) chain precursor - Homo sapiens (Human) - COL24A1 gene May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development. Taurus_UMD|evm.model.AC_000160.1.750 Q1RML4 SPIC_BOVIN 94.196 0.873016 1.01613 SPIC - Transcription factor Spi-C - Bos taurus (Bovine) - SPIC gene Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity). Taurus_UMD|evm.model.AC_000160.1.751 Q17RW2 COOA1_HUMAN 90.090 0.982143 0.0653442 COL24A1 - Collagen alpha-1(XXIV) chain precursor - Homo sapiens (Human) - COL24A1 gene May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development. Taurus_UMD|evm.model.AC_000160.1.752 Q9NWK9 BCD1_HUMAN 77.474 0.995754 1.00213 ZNHIT6 - Box C/D snoRNA protein 1 - Homo sapiens (Human) - ZNHIT6 gene Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. Taurus_UMD|evm.model.AC_000160.1.754 O00622 CCN1_HUMAN 92.932 0.994778 1.00525 CCN1 - CCN family member 1 precursor - Homo sapiens (Human) - CCN1 gene Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Taurus_UMD|evm.model.AC_000160.1.755 P56965 DDAH1_BOVIN 100.000 0.993007 1.00351 DDAH1 - N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 - Bos taurus (Bovine) - DDAH1 gene Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. Taurus_UMD|evm.model.AC_000160.1.756 O95999 BCL10_HUMAN 95.279 0.991342 0.991416 BCL10 - B-cell lymphoma/leukemia 10 - Homo sapiens (Human) - BCL10 gene Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:25365219, PubMed:24074955). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:27777308, PubMed:24074955). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:27777308, PubMed:24074955). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815). Taurus_UMD|evm.model.AC_000160.1.757 Q32LF5 CA052_BOVIN 100.000 0.989071 1.00549 UPF0690 protein C1orf52 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000160.1.758 Q5VT97 SYDE2_HUMAN 83.319 0.860668 1.1541 SYDE2 - Rho GTPase-activating protein SYDE2 - Homo sapiens (Human) - SYDE2 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000160.1.759 Q8IWG1 DNAI3_HUMAN 85.762 0.99776 1.00224 DNAI3 - Dynein axonemal intermediate chain 3 - Homo sapiens (Human) - DNAI3 gene Acts as a negative regulator of cell migration, invasion, and metastasis downstream of p53/TP53, through inhibition of Arp2/3 complex-mediated actin polymerization (PubMed:32128961). Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function (By similarity). May play a role in osteogenesis of dental tissue-derived mesenchymal stem cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.760 Q8TDD5 MCLN3_HUMAN 92.767 0.951724 1.04882 MCOLN3 - Mucolipin-3 - Homo sapiens (Human) - MCOLN3 gene Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840, PubMed:29106414). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (PubMed:21245134). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy (PubMed:19522758). Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (PubMed:23469151). Taurus_UMD|evm.model.AC_000160.1.761 Q8IZK6 MCLN2_HUMAN 85.236 0.972868 0.911661 MCOLN2 - Mucolipin-2 - Homo sapiens (Human) - MCOLN2 gene Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Taurus_UMD|evm.model.AC_000160.1.762 Q9UBY5 LPAR3_HUMAN 90.960 0.99435 1.00283 LPAR3 - Lysophosphatidic acid receptor 3 - Homo sapiens (Human) - LPAR3 gene Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. Taurus_UMD|evm.model.AC_000160.1.764 Q9Y2D8 ADIP_HUMAN 94.797 0.996753 1.00326 SSX2IP - Afadin- and alpha-actinin-binding protein - Homo sapiens (Human) - SSX2IP gene Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). Taurus_UMD|evm.model.AC_000160.1.765 Q01458 DIAC_BOVIN 98.286 0.460317 2.16 CTBS - Di-N-acetylchitobiase precursor - Bos taurus (Bovine) - CTBS gene Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase. Taurus_UMD|evm.model.AC_000160.1.766 Q5VX52 SPAT1_HUMAN 77.566 0.846154 1.07625 SPATA1 - Spermatogenesis-associated protein 1 - Homo sapiens (Human) - SPATA1 gene Taurus_UMD|evm.model.AC_000160.1.767 Q9H9Y2 RPF1_HUMAN 95.415 0.994286 1.00287 RPF1 - Ribosome production factor 1 - Homo sapiens (Human) - RPF1 gene May be required for ribosome biogenesis. Taurus_UMD|evm.model.AC_000160.1.768 Q8NGB4 OR4S1_HUMAN 82.000 0.792 0.404531 OR4S1 - Olfactory receptor 4S1 - Homo sapiens (Human) - OR4S1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000160.1.769 Q8WZ79 DNS2B_HUMAN 86.517 0.99162 0.99169 DNASE2B - Deoxyribonuclease-2-beta precursor - Homo sapiens (Human) - DNASE2B gene Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation. Taurus_UMD|evm.model.AC_000160.1.770 Q3MHG7 URIC_BOVIN 100.000 0.912651 1.09211 UOX - Uricase - Bos taurus (Bovine) - UOX gene Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Taurus_UMD|evm.model.AC_000160.1.771 Q5VXD3 SAM13_HUMAN 97.059 0.980583 0.844262 SAMD13 - Sterile alpha motif domain-containing protein 13 - Homo sapiens (Human) - SAMD13 gene nucleus, chromatin binding, histone binding, negative regulation of transcription, DNA-templated Taurus_UMD|evm.model.AC_000160.1.772 P05131 KAPCB_BOVIN 100.000 0.994318 1.00285 PRKACB - cAMP-dependent protein kinase catalytic subunit beta - Bos taurus (Bovine) - PRKACB gene Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, and differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Taurus_UMD|evm.model.AC_000160.1.773 Q5RFF4 EIF1_PONAB 100.000 0.982456 1.00885 EIF1 - Eukaryotic translation initiation factor 1 - Pongo abelii (Sumatran orangutan) - EIF1 gene Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA (By similarity). Taurus_UMD|evm.model.AC_000160.1.774 Q6ZT98 TTLL7_HUMAN 94.250 0.997748 1.00113 TTLL7 - Tubulin polyglutamylase TTLL7 - Homo sapiens (Human) - TTLL7 gene Polyglutamylase which preferentially modifies beta-tubulin (PubMed:25959773). Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules (PubMed:25959773). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity). Taurus_UMD|evm.model.AC_000160.1.778 O62829 PPM1A_BOVIN 98.917 0.992806 0.727749 PPM1A - Protein phosphatase 1A - Bos taurus (Bovine) - PPM1A gene Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). Taurus_UMD|evm.model.AC_000160.1.779 O02751 CFDP2_BOVIN 76.154 0.984733 0.221284 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000160.1.780 O97817 AGRL2_BOVIN 97.632 0.998618 0.979026 ADGRL2 - Adhesion G protein-coupled receptor L2 precursor - Bos taurus (Bovine) - ADGRL2 gene Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Taurus_UMD|evm.model.AC_000160.1.782 Q32L59 TMC5B_BOVIN 97.143 0.151111 0.641026 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Taurus_UMD|evm.model.AC_000160.1.783 Q95SX7 RTBS_DROME 30.328 0.62766 0.207506 RTase - Probable RNA-directed DNA polymerase from transposon BS - Drosophila melanogaster (Fruit fly) - RTase gene RNA-directed DNA polymerase activity, transposition, DNA-mediated Taurus_UMD|evm.model.AC_000160.1.784 B1AR13 CISD3_MOUSE 82.759 0.398601 1.0438 Cisd3 - CDGSH iron-sulfur domain-containing protein 3, mitochondrial precursor - Mus musculus (Mouse) - Cisd3 gene Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function. Taurus_UMD|evm.model.AC_000160.1.785 P15927 RFA2_HUMAN 87.854 0.878571 1.03704 RPA2 - Replication protein A 32 kDa subunit - Homo sapiens (Human) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Taurus_UMD|evm.model.AC_000160.1.786 Q96PZ7 CSMD1_HUMAN 91.429 0.896552 0.0325477 CSMD1 - CUB and sushi domain-containing protein 1 precursor - Homo sapiens (Human) - CSMD1 gene Potential suppressor of squamous cell carcinomas. Taurus_UMD|evm.model.AC_000160.1.787 Q9HBW9 AGRL4_HUMAN 88.116 0.997101 1 ADGRL4 - Adhesion G protein-coupled receptor L4 precursor - Homo sapiens (Human) - ADGRL4 gene Endothelial orphan receptor that acts as a key regulator of angiogenesis. Taurus_UMD|evm.model.AC_000160.1.788 P27473 IFI44_PANTR 60.748 0.935556 1.01351 IFI44 - Interferon-induced protein 44 - Pan troglodytes (Chimpanzee) - IFI44 gene This protein aggregates to form microtubular structures. Taurus_UMD|evm.model.AC_000160.1.789 Q53G44 IF44L_HUMAN 63.575 0.995475 0.977876 IFI44L - Interferon-induced protein 44-like - Homo sapiens (Human) - IFI44L gene Exhibits a low antiviral activity against hepatitis C virus. Taurus_UMD|evm.model.AC_000160.1.790 P37289 PF2R_BOVIN 99.724 0.99449 1.00276 PTGFR - Prostaglandin F2-alpha receptor - Bos taurus (Bovine) - PTGFR gene Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Taurus_UMD|evm.model.AC_000160.1.791 Q0VCY3 SURF6_BOVIN 41.667 0.881188 0.286119 SURF6 - Surfeit locus protein 6 - Bos taurus (Bovine) - SURF6 gene Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). Taurus_UMD|evm.model.AC_000160.1.792 Q56JY1 RL35A_BOVIN 95.455 0.981982 1.00909 RPL35A - 60S ribosomal protein L35a - Bos taurus (Bovine) - RPL35A gene Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation (By similarity). The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site (By similarity). Taurus_UMD|evm.model.AC_000160.1.793 Q1JQD4 GIPC2_BOVIN 100.000 0.993631 1.00319 GIPC2 - PDZ domain-containing protein GIPC2 - Bos taurus (Bovine) - GIPC2 gene Taurus_UMD|evm.model.AC_000160.1.794 Q2KIT4 DNJB4_BOVIN 100.000 0.994083 1.00297 DNAJB4 - DnaJ homolog subfamily B member 4 - Bos taurus (Bovine) - DNAJB4 gene Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Taurus_UMD|evm.model.AC_000160.1.795 Q96AE4 FUBP1_HUMAN 88.942 0.896923 1.00932 FUBP1 - Far upstream element-binding protein 1 - Homo sapiens (Human) - FUBP1 gene Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. Taurus_UMD|evm.model.AC_000160.1.796 Q0ZGT2 NEXN_HUMAN 93.759 0.992614 1.00296 NEXN - Nexilin - Homo sapiens (Human) - NEXN gene Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. Taurus_UMD|evm.model.AC_000160.1.797 Q8NAN2 MIGA1_HUMAN 87.086 0.898089 0.993671 MIGA1 - Mitoguardin 1 - Homo sapiens (Human) - MIGA1 gene Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. Taurus_UMD|evm.model.AC_000160.1.798 A6QNM7 UBP33_BOVIN 100.000 0.997809 1.0011 USP33 - Ubiquitin carboxyl-terminal hydrolase 33 - Bos taurus (Bovine) - USP33 gene Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Taurus_UMD|evm.model.AC_000160.1.799 Q8IYH5 ZZZ3_HUMAN 94.020 0.997788 1.00111 ZZZ3 - ZZ-type zinc finger-containing protein 3 - Homo sapiens (Human) - ZZZ3 gene Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Taurus_UMD|evm.model.AC_000160.1.800 A4IFD0 KAD5_BOVIN 100.000 0.995283 0.754448 Ak5 - Adenylate kinase isoenzyme 5 - Bos taurus (Bovine) - Ak5 gene Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. Taurus_UMD|evm.model.AC_000160.1.801 Q3MHZ7 GPI8_BOVIN 90.380 0.994429 0.908861 PIGK - GPI-anchor transamidase precursor - Bos taurus (Bovine) - PIGK gene Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity). Taurus_UMD|evm.model.AC_000160.1.802 Q9BVH7 SIA7E_HUMAN 81.250 0.993243 0.880952 ST6GALNAC5 - Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 - Homo sapiens (Human) - ST6GALNAC5 gene Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transfering the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b (PubMed:12668675). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1 Taurus_UMD|evm.model.AC_000160.1.803 Q8NDV1 SIA7C_HUMAN 98.551 0.971429 0.229508 ST6GALNAC3 - Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 - Homo sapiens (Human) - ST6GALNAC3 gene Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:16169874, PubMed:17123352). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (PubMed:17123352). Taurus_UMD|evm.model.AC_000160.1.806 Q32KY8 ASB17_BOVIN 99.661 0.993243 1.00339 ASB17 - Ankyrin repeat and SOCS box protein 17 - Bos taurus (Bovine) - ASB17 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000160.1.807 Q5E9B3 PGTB2_BOVIN 100.000 0.264943 3.74018 RABGGTB - Geranylgeranyl transferase type-2 subunit beta - Bos taurus (Bovine) - RABGGTB gene Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. Taurus_UMD|evm.model.AC_000160.1.808 Q3SZB4 ACADM_BOVIN 100.000 0.995261 1.00238 ACADM - Medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ACADM gene Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains. Taurus_UMD|evm.model.AC_000160.1.810 Q95JW2 CTL5_MACFA 75.592 0.997046 0.944212 SLC44A5 - Choline transporter-like protein 5 - Macaca fascicularis (Crab-eating macaque) - SLC44A5 gene Taurus_UMD|evm.model.AC_000160.1.811 O35652 LHX8_MOUSE 96.875 0.471774 2.02725 Lhx8 - LIM/homeobox protein Lhx8 - Mus musculus (Mouse) - Lhx8 gene Transcription factor involved in differentiation of certain neurons and mesenchymal cells. Taurus_UMD|evm.model.AC_000160.1.812 Q5E9U4 TYW3_BOVIN 100.000 0.992278 1.00388 TYW3 - tRNA wybutosine-synthesizing protein 3 homolog - Bos taurus (Bovine) - TYW3 gene Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). Taurus_UMD|evm.model.AC_000160.1.813 O97764 QOR_BOVIN 100.000 0.993958 1.00303 CRYZ - Zeta-crystallin - Bos taurus (Bovine) - CRYZ gene Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity). Has minimal or no quinone reductase activity. Binds strongly to single-stranded DNA. Taurus_UMD|evm.model.AC_000160.1.814 Q5RHP9 ERIC3_HUMAN 83.735 0.337636 0.962092 ERICH3 - Glutamate-rich protein 3 - Homo sapiens (Human) - ERICH3 gene Taurus_UMD|evm.model.AC_000160.1.815 Q5RF15 TNI3K_PONAB 96.780 0.704545 1.35275 TNNI3K - Serine/threonine-protein kinase TNNI3K - Pongo abelii (Sumatran orangutan) - TNNI3K gene May play a role in cardiac physiology. Taurus_UMD|evm.model.AC_000160.1.816 O14772 FPGT_HUMAN 85.908 0.978369 0.990115 FPGT - Fucose-1-phosphate guanylyltransferase - Homo sapiens (Human) - FPGT gene Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. Taurus_UMD|evm.model.AC_000160.1.817 A6PVS8 LRIQ3_HUMAN 87.692 0.984772 0.315705 LRRIQ3 - Leucine-rich repeat and IQ domain-containing protein 3 - Homo sapiens (Human) - LRRIQ3 gene Taurus_UMD|evm.model.AC_000160.1.818 Q6AYK1 RNPS1_RAT 77.551 0.40678 0.386885 Rnps1 - RNA-binding protein with serine-rich domain 1 - Rattus norvegicus (Rat) - Rnps1 gene Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity). Taurus_UMD|evm.model.AC_000160.1.819 A6PVS8 LRIQ3_HUMAN 60.473 0.976821 0.483974 LRRIQ3 - Leucine-rich repeat and IQ domain-containing protein 3 - Homo sapiens (Human) - LRRIQ3 gene Taurus_UMD|evm.model.AC_000160.1.820 Q3MHR7 ARPC2_BOVIN 73.737 0.919192 0.99 ARPC2 - Actin-related protein 2/3 complex subunit 2 - Bos taurus (Bovine) - ARPC2 gene Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Taurus_UMD|evm.model.AC_000160.1.821 Q5R412 NEGR1_PONAB 99.265 0.668317 0.570621 NEGR1 - Neuronal growth regulator 1 precursor - Pongo abelii (Sumatran orangutan) - NEGR1 gene May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity). Taurus_UMD|evm.model.AC_000160.1.823 Q7Z3B1 NEGR1_HUMAN 97.753 0.637681 0.389831 NEGR1 - Neuronal growth regulator 1 precursor - Homo sapiens (Human) - NEGR1 gene May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity). Taurus_UMD|evm.model.AC_000160.1.824 Q5R580 ZRAB2_PONAB 99.676 0.930514 1.03438 ZRANB2 - Zinc finger Ran-binding domain-containing protein 2 - Pongo abelii (Sumatran orangutan) - ZRANB2 gene Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection (By similarity). Taurus_UMD|evm.model.AC_000160.1.825 P34979 PE2R3_BOVIN 100.000 0.978082 0.8753 PTGER3 - Prostaglandin E2 receptor EP3 subtype - Bos taurus (Bovine) - PTGER3 gene Receptor for prostaglandin E2 (PGE2) (PubMed:8396726). The various isoforms have identical ligand binding properties but interact with different second messenger systems: isoform EP3A couples to G(i)/G(o) proteins; isoform EP3B and isoform EP3C couple to G(s), and isoform EP3D couples to G(i), G(s) and G(p) (PubMed:8396726). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity). Taurus_UMD|evm.model.AC_000160.1.826 Q58DW2 CGL_BOVIN 99.753 0.946136 1.05432 CTH - Cystathionine gamma-lyase - Bos taurus (Bovine) - CTH gene Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (By similarity). Taurus_UMD|evm.model.AC_000160.1.827 Q8N6S4 AN13C_HUMAN 76.051 0.995726 0.865065 ANKRD13C - Ankyrin repeat domain-containing protein 13C - Homo sapiens (Human) - ANKRD13C gene Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER. Taurus_UMD|evm.model.AC_000160.1.828 Q05519 SRS11_HUMAN 98.347 0.851327 1.16736 SRSF11 - Serine/arginine-rich splicing factor 11 - Homo sapiens (Human) - SRSF11 gene May function in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000160.1.829 Q4R3P6 LRC40_MACFA 93.116 0.989228 0.925249 LRRC40 - Leucine-rich repeat-containing protein 40 - Macaca fascicularis (Crab-eating macaque) - LRRC40 gene Taurus_UMD|evm.model.AC_000160.1.830 F1MCA7 LRRC7_BOVIN 99.779 0.976208 0.902995 LRRC7 - Leucine-rich repeat-containing protein 7 - Bos taurus (Bovine) - LRRC7 gene Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression (By similarity). Taurus_UMD|evm.model.AC_000160.1.832 Q5TB30 DEP1A_HUMAN 86.050 0.979408 0.958076 DEPDC1 - DEP domain-containing protein 1A - Homo sapiens (Human) - DEPDC1 gene May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. Taurus_UMD|evm.model.AC_000160.1.833 A4IFF3 TTC9C_BOVIN 98.246 0.988372 1.00585 TTC9C - Tetratricopeptide repeat protein 9C - Bos taurus (Bovine) - TTC9C gene Taurus_UMD|evm.model.AC_000160.1.834 Q28175 RPE65_BOVIN 99.812 0.996255 1.00188 RPE65 - Retinoid isomerohydrolase - Bos taurus (Bovine) - RPE65 gene Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16096063, PubMed:19805034, PubMed:20100834). Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (By similarity). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (PubMed:15186777). Taurus_UMD|evm.model.AC_000160.1.837 O95661 DIRA3_HUMAN 56.838 0.991453 1.02183 DIRAS3 - GTP-binding protein Di-Ras3 precursor - Homo sapiens (Human) - DIRAS3 gene plasma membrane, GDP binding, GTP binding, GTPase activity, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of gene expression by genetic imprinting, small GTPase mediated signal transduction Taurus_UMD|evm.model.AC_000160.1.838 Q28024 GBG12_BOVIN 100.000 0.972603 1.01389 GNG12 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 precursor - Bos taurus (Bovine) - GNG12 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Taurus_UMD|evm.model.AC_000160.1.839 Q3ZBN6 GA45A_BOVIN 100.000 0.987952 1.00606 GADD45A - Growth arrest and DNA damage-inducible protein GADD45 alpha - Bos taurus (Bovine) - GADD45A gene Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Taurus_UMD|evm.model.AC_000160.1.840 Q8NC51 PAIRB_HUMAN 99.020 0.995098 1 SERBP1 - Plasminogen activator inhibitor 1 RNA-binding protein - Homo sapiens (Human) - SERBP1 gene May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). Taurus_UMD|evm.model.AC_000160.1.841 Q9BEG2 I12R2_BOVIN 99.760 0.997608 0.970964 IL12RB2 - Interleukin-12 receptor subunit beta-2 precursor - Bos taurus (Bovine) - IL12RB2 gene Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. On IL12 stimulation, enhances IFN-gamma expression. Taurus_UMD|evm.model.AC_000160.1.842 Q5VWK5 IL23R_HUMAN 72.425 0.970486 0.915739 IL23R - Interleukin-23 receptor precursor - Homo sapiens (Human) - IL23R gene Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Taurus_UMD|evm.model.AC_000160.1.843 Q3SYW6 EIF3C_BOVIN 81.250 0.407895 0.0833333 EIF3C - Eukaryotic translation initiation factor 3 subunit C - Bos taurus (Bovine) - EIF3C gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Taurus_UMD|evm.model.AC_000160.1.844 Q2KIL1 CA141_BOVIN 99.767 0.99536 1.00233 Uncharacterized protein C1orf141 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000160.1.845 A2VE55 S35D2_BOVIN 100.000 0.994382 1.00282 SLC35D2 - UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter - Bos taurus (Bovine) - SLC35D2 gene Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-GlcNAc, the donor substrate, and thus be involved in growth factor signaling (By similarity). Taurus_UMD|evm.model.AC_000160.1.846 Q8N108 MIER1_HUMAN 96.071 0.897163 1.10156 MIER1 - Mesoderm induction early response protein 1 - Homo sapiens (Human) - MIER1 gene Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. Taurus_UMD|evm.model.AC_000160.1.847 Q5VTH9 DNAI4_HUMAN 81.381 0.991432 0.963443 DNAI4 - Dynein axonemal intermediate chain 4 - Homo sapiens (Human) - DNAI4 gene Plays a critical role in the assembly of axonemal dynein complex, thereby playing a role in ciliary motility. Taurus_UMD|evm.model.AC_000160.1.848 Q5CZK5 INSL5_PANTR 68.889 0.985294 1.00741 INSL5 - Insulin-like peptide INSL5 precursor - Pan troglodytes (Chimpanzee) - INSL5 gene May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity). Taurus_UMD|evm.model.AC_000160.1.849 Q8N7M0 DYLT5_HUMAN 82.486 0.988764 0.994413 DYNLT5 - Dynein light chain Tctex-type 5 - Homo sapiens (Human) - DYNLT5 gene Taurus_UMD|evm.model.AC_000160.1.850 Q9BQI5 SGIP1_HUMAN 88.747 0.997611 1.01087 SGIP1 - SH3-containing GRB2-like protein 3-interacting protein 1 - Homo sapiens (Human) - SGIP1 gene May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. Taurus_UMD|evm.model.AC_000160.1.852 Q07343 PDE4B_HUMAN 97.196 0.993798 0.876359 PDE4B - cAMP-specific 3',5'-cyclic phosphodiesterase 4B - Homo sapiens (Human) - PDE4B gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. Taurus_UMD|evm.model.AC_000160.1.853 O02671 LEPR_PIG 84.549 0.998224 0.966524 LEPR - Leptin receptor precursor - Sus scrofa (Pig) - LEPR gene Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (By similarity). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity). Taurus_UMD|evm.model.AC_000160.1.855 Q3SYT0 OBRG_BOVIN 100.000 0.984848 1.00763 LEPROT - Leptin receptor gene-related protein - Bos taurus (Bovine) - LEPROT gene Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin/LEP. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity). Taurus_UMD|evm.model.AC_000160.1.856 Q27974 AUXI_BOVIN 99.890 0.935185 1.06813 DNAJC6 - Putative tyrosine-protein phosphatase auxilin - Bos taurus (Bovine) - DNAJC6 gene Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (PubMed:15502813). Plays a role in clathrin-mediated endocytosis in neurons (By similarity). Taurus_UMD|evm.model.AC_000160.1.857 Q0VCP1 KAD4_BOVIN 100.000 0.991071 1.00448 AK4 - Adenylate kinase 4, mitochondrial - Bos taurus (Bovine) - AK4 gene Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). Also displays broad nucleoside diphosphate kinase activity (By similarity). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity). Plays a protective role in the cellular response to oxidative stress (By similarity). Taurus_UMD|evm.model.AC_000160.1.858 P24049 RL17_RAT 81.481 0.924138 0.788043 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000160.1.860 P23458 JAK1_HUMAN 97.140 0.99396 1.00433 JAK1 - Tyrosine-protein kinase JAK1 - Homo sapiens (Human) - JAK1 gene Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Taurus_UMD|evm.model.AC_000160.1.861 Q4KM98 MFF_RAT 69.048 0.372727 0.504587 Mff - Mitochondrial fission factor - Rattus norvegicus (Rat) - Mff gene Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. Taurus_UMD|evm.model.AC_000160.1.862 Q9HCJ3 RAVR2_HUMAN 90.523 0.922844 0.956585 RAVER2 - Ribonucleoprotein PTB-binding 2 - Homo sapiens (Human) - RAVER2 gene May bind single-stranded nucleic acids. Taurus_UMD|evm.model.AC_000160.1.863 Q5VU97 CAHD1_HUMAN 96.739 0.998448 1.01177 CACHD1 - VWFA and cache domain-containing protein 1 precursor - Homo sapiens (Human) - CACHD1 gene May regulate voltage-dependent calcium channels. Taurus_UMD|evm.model.AC_000160.1.864 Q5VVX9 UBE2U_HUMAN 58.696 0.992933 0.88162 UBE2U - Ubiquitin-conjugating enzyme E2 U - Homo sapiens (Human) - UBE2U gene Catalyzes the covalent attachment of ubiquitin to other proteins. Taurus_UMD|evm.model.AC_000160.1.865 Q01973 ROR1_HUMAN 98.124 0.997795 0.967983 ROR1 - Inactive tyrosine-protein kinase transmembrane receptor ROR1 precursor - Homo sapiens (Human) - ROR1 gene Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Taurus_UMD|evm.model.AC_000160.1.866 Q08DP0 PGM1_BOVIN 100.000 0.456469 2.18683 PGM1 - Phosphoglucomutase-1 - Bos taurus (Bovine) - PGM1 gene This enzyme participates in both the breakdown and synthesis of glucose. Taurus_UMD|evm.model.AC_000160.1.868 Q9Y672 ALG6_HUMAN 95.152 0.959064 0.337278 ALG6 - Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase - Homo sapiens (Human) - ALG6 gene Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. Taurus_UMD|evm.model.AC_000160.1.869 Q63245 FOXD3_RAT 100.000 0.207469 4.77228 Foxd3 - Forkhead box protein D3 - Rattus norvegicus (Rat) - Foxd3 gene Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (By similarity). Taurus_UMD|evm.model.AC_000160.1.870 Q96DT6 ATG4C_HUMAN 94.105 0.995643 1.00218 ATG4C - Cysteine protease ATG4C - Homo sapiens (Human) - ATG4C gene Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Taurus_UMD|evm.model.AC_000160.1.871 Q96N67 DOCK7_HUMAN 94.720 0.999031 0.964019 DOCK7 - Dedicator of cytokinesis protein 7 - Homo sapiens (Human) - DOCK7 gene Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). Taurus_UMD|evm.model.AC_000160.1.872 Q29RP1 UBP1_BOVIN 97.358 0.997323 0.954023 USP1 - Ubiquitin carboxyl-terminal hydrolase 1 - Bos taurus (Bovine) - USP1 gene Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Taurus_UMD|evm.model.AC_000160.1.873 Q5T7N3 KANK4_HUMAN 78.205 0.895575 1.13568 KANK4 - KN motif and ankyrin repeat domain-containing protein 4 - Homo sapiens (Human) - KANK4 gene May be involved in the control of cytoskeleton formation by regulating actin polymerization. Taurus_UMD|evm.model.AC_000160.1.874 Q96N20 ZN75A_HUMAN 71.845 0.445415 0.773649 ZNF75A - Zinc finger protein 75A - Homo sapiens (Human) - ZNF75A gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000160.1.875 E2QYC9 INADL_CANLF 85.628 0.952253 1.01969 PATJ - InaD-like protein - Canis lupus familiaris (Dog) - PATJ gene Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:17235357). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:15738264). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (PubMed:17235357). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (PubMed:17235357). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (By similarity). Taurus_UMD|evm.model.AC_000160.1.876 Q9BX74 TM2D1_HUMAN 77.295 0.988701 0.855072 TM2D1 - TM2 domain-containing protein 1 precursor - Homo sapiens (Human) - TM2D1 gene May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42. Taurus_UMD|evm.model.AC_000160.1.878 P02694 RET1_BOVIN 95.556 0.985294 1.00741 RBP1 - Retinol-binding protein 1 - Bos taurus (Bovine) - RBP1 gene Cytoplasmic retinol-binding protein (PubMed:7744071). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis. Taurus_UMD|evm.model.AC_000160.1.879 Q12857 NFIA_HUMAN 100.000 0.996078 1.00196 NFIA - Nuclear factor 1 A-type - Homo sapiens (Human) - NFIA gene Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Taurus_UMD|evm.model.AC_000160.1.881 Q58DW0 RL4_BOVIN 85.821 0.826087 0.381517 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Taurus_UMD|evm.model.AC_000160.1.882 Q58DW0 RL4_BOVIN 88.384 0.938095 0.49763 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Taurus_UMD|evm.model.AC_000160.1.883 Q5H8C1 FREM1_HUMAN 55.882 0.553719 0.0555301 FREM1 - FRAS1-related extracellular matrix protein 1 precursor - Homo sapiens (Human) - FREM1 gene Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development. Taurus_UMD|evm.model.AC_000160.1.884 Q8N0U7 CA087_HUMAN 67.355 0.995902 0.893773 C1orf87 - Uncharacterized protein C1orf87 - Homo sapiens (Human) - C1orf87 gene Taurus_UMD|evm.model.AC_000160.1.885 P51589 CP2J2_HUMAN 80.080 0.996024 1.00199 CYP2J2 - Cytochrome P450 2J2 - Homo sapiens (Human) - CYP2J2 gene A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). Taurus_UMD|evm.model.AC_000160.1.886 P51589 CP2J2_HUMAN 56.250 0.95 0.398406 CYP2J2 - Cytochrome P450 2J2 - Homo sapiens (Human) - CYP2J2 gene A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). Taurus_UMD|evm.model.AC_000160.1.887 P51589 CP2J2_HUMAN 74.052 0.994036 1.00199 CYP2J2 - Cytochrome P450 2J2 - Homo sapiens (Human) - CYP2J2 gene A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). Taurus_UMD|evm.model.AC_000160.1.888 P51589 CP2J2_HUMAN 75.896 0.996024 1.00199 CYP2J2 - Cytochrome P450 2J2 - Homo sapiens (Human) - CYP2J2 gene A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). Taurus_UMD|evm.model.AC_000160.1.889 P52786 CP2J1_RABIT 64.545 0.717105 0.303393 CYP2J1 - Cytochrome P450 2J1 - Oryctolagus cuniculus (Rabbit) - CYP2J1 gene Catalyzes the N-demethylation of benzphetamine to formaldehyde. Taurus_UMD|evm.model.AC_000160.1.890 O54750 CP2J6_MOUSE 77.143 0.825397 0.251497 Cyp2j6 - Cytochrome P450 2J6 - Mus musculus (Mouse) - Cyp2j6 gene cytoplasm, endoplasmic reticulum, intracellular membrane-bounded organelle, arachidonic acid 11,12-epoxygenase activity, arachidonic acid 14,15-epoxygenase activity, arachidonic acid epoxygenase activity, heme binding, isomerase activity, linoleic acid epoxygenase activity, NADPH-hemoprotein reductase activity Taurus_UMD|evm.model.AC_000160.1.891 P51589 CP2J2_HUMAN 85.714 0.986301 0.436255 CYP2J2 - Cytochrome P450 2J2 - Homo sapiens (Human) - CYP2J2 gene A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). Taurus_UMD|evm.model.AC_000160.1.892 P51589 CP2J2_HUMAN 78.472 0.947253 0.906375 CYP2J2 - Cytochrome P450 2J2 - Homo sapiens (Human) - CYP2J2 gene A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). Taurus_UMD|evm.model.AC_000160.1.893 Q9UJC3 HOOK1_HUMAN 95.742 0.997257 1.00137 HOOK1 - Protein Hook homolog 1 - Homo sapiens (Human) - HOOK1 gene Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:18799622, PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Taurus_UMD|evm.model.AC_000160.1.894 Q9XSG3 IDHC_BOVIN 93.897 0.929825 0.550725 IDH1 - Isocitrate dehydrogenase [NADP] cytoplasmic - Bos taurus (Bovine) - IDH1 gene May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency. Taurus_UMD|evm.model.AC_000160.1.895 Q96C11 FGGY_HUMAN 92.196 0.933673 1.06715 FGGY - FGGY carbohydrate kinase domain-containing protein - Homo sapiens (Human) - FGGY gene D-ribulokinase activity, carbohydrate phosphorylation, neuron cellular homeostasis, pentose metabolic process Taurus_UMD|evm.model.AC_000160.1.897 O77627 JUN_BOVIN 100.000 0.994048 1.00299 JUN - Transcription factor AP-1 - Bos taurus (Bovine) - JUN gene Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter. Taurus_UMD|evm.model.AC_000160.1.898 Q5VVJ2 MYSM1_HUMAN 86.826 0.997596 1.00483 MYSM1 - Deubiquitinase MYSM1 - Homo sapiens (Human) - MYSM1 gene Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232). Taurus_UMD|evm.model.AC_000160.1.899 P09758 TACD2_HUMAN 80.667 0.934375 0.990712 TACSTD2 - Tumor-associated calcium signal transducer 2 precursor - Homo sapiens (Human) - TACSTD2 gene May function as a growth factor receptor. Taurus_UMD|evm.model.AC_000160.1.900 Q3SZN3 OMA1_BOVIN 100.000 0.996183 1.00191 OMA1 - Metalloendopeptidase OMA1, mitochondrial precursor - Bos taurus (Bovine) - OMA1 gene Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion (By similarity). Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae. In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome. May also cleave UQCC3 in response to mitochondrial depolarization. Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (By similarity). Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Binds cardiolipin, possibly regulating its protein turnover. Required for the stability of the respiratory supercomplexes (By similarity). Taurus_UMD|evm.model.AC_000160.1.904 P62755 RS6_RAT 71.901 0.952381 0.506024 Rps6 - 40S ribosomal protein S6 - Rattus norvegicus (Rat) - Rps6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Taurus_UMD|evm.model.AC_000160.1.905 Q8CJH2 DAB1_RAT 97.137 0.937276 1.00541 Dab1 - Disabled homolog 1 - Rattus norvegicus (Rat) - Dab1 gene Adapter molecule functioning in neural development. May regulate SIAH1 activity. Taurus_UMD|evm.model.AC_000160.1.906 P07358 CO8B_HUMAN 82.542 0.996616 1 C8B - Complement component C8 beta chain precursor - Homo sapiens (Human) - C8B gene Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Taurus_UMD|evm.model.AC_000160.1.907 P07357 CO8A_HUMAN 76.298 0.996546 0.991438 C8A - Complement component C8 alpha chain precursor - Homo sapiens (Human) - C8A gene Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself. Taurus_UMD|evm.model.AC_000160.1.908 Q5VWT5 FYB2_HUMAN 58.078 0.768519 1.18681 FYB2 - FYN-binding protein 2 - Homo sapiens (Human) - FYB2 gene Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation (PubMed:27335501). Taurus_UMD|evm.model.AC_000160.1.909 Q28948 AAPK2_PIG 98.370 0.996383 1.00181 PRKAA2 - 5'-AMP-activated protein kinase catalytic subunit alpha-2 - Sus scrofa (Pig) - PRKAA2 gene Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. nvolved in insulin receptor/INSR internalization. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. In that process also activates WDR45. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1. Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation. Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1. Taurus_UMD|evm.model.AC_000160.1.910 Q3SZE3 PLPP3_BOVIN 100.000 0.99359 1.00322 PLPP3 - Phospholipid phosphatase 3 - Bos taurus (Bovine) - PLPP3 gene Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines (By similarity). By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (By similarity). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers (By similarity). Taurus_UMD|evm.model.AC_000160.1.911 Q9P265 DIP2B_HUMAN 92.308 0.980769 0.0329949 DIP2B - Disco-interacting protein 2 homolog B - Homo sapiens (Human) - DIP2B gene Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. Taurus_UMD|evm.model.AC_000160.1.914 Q9UPU5 UBP24_HUMAN 98.626 0.999236 0.999237 USP24 - Ubiquitin carboxyl-terminal hydrolase 24 - Homo sapiens (Human) - USP24 gene Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. Taurus_UMD|evm.model.AC_000160.1.916 Q8WZ55 BSND_HUMAN 74.534 0.99375 1 BSND - Barttin - Homo sapiens (Human) - BSND gene Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter. Taurus_UMD|evm.model.AC_000160.1.917 Q8N0U2 TMM61_HUMAN 68.095 0.990521 1.00476 TMEM61 - Transmembrane protein 61 - Homo sapiens (Human) - TMEM61 gene Taurus_UMD|evm.model.AC_000160.1.919 Q15392 DHC24_HUMAN 96.899 0.996132 1.00194 DHCR24 - Delta(24)-sterol reductase precursor - Homo sapiens (Human) - DHCR24 gene Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:25637936, PubMed:22178193). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress (PubMed:11007892, PubMed:22010141). Also protects against amyloid-beta peptide-induced apoptosis (PubMed:11007892). Taurus_UMD|evm.model.AC_000160.1.920 Q3ZCV2 LEXM_HUMAN 78.191 0.991935 0.889952 LEXM - Lymphocyte expansion molecule - Homo sapiens (Human) - LEXM gene Taurus_UMD|evm.model.AC_000160.1.921 Q5TAA0 TTC22_HUMAN 91.021 0.994737 1.00176 TTC22 - Tetratricopeptide repeat protein 22 - Homo sapiens (Human) - TTC22 gene Taurus_UMD|evm.model.AC_000160.1.922 Q7L3T8 SYPM_HUMAN 86.737 0.995798 1.00211 PARS2 - Probable proline--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - PARS2 gene mitochondrion, proline-tRNA ligase activity, prolyl-tRNA aminoacylation Taurus_UMD|evm.model.AC_000160.1.923 Q5EA11 TTC4_BOVIN 98.969 0.974811 1.0232 TTC4 - Tetratricopeptide repeat protein 4 - Bos taurus (Bovine) - TTC4 gene May act as a co-chaperone for HSP90AB1 (By similarity). Taurus_UMD|evm.model.AC_000160.1.924 Q68CQ1 MROH7_HUMAN 76.090 0.998481 0.995465 MROH7 - Maestro heat-like repeat-containing protein family member 7 - Homo sapiens (Human) - MROH7 gene extracellular space Taurus_UMD|evm.model.AC_000160.1.925 Q5RDY9 F151A_PONAB 78.022 0.92845 1.00342 FAM151A - Protein FAM151A - Pongo abelii (Sumatran orangutan) - FAM151A gene Taurus_UMD|evm.model.AC_000160.1.926 Q8WXI4 ACO11_HUMAN 88.525 0.530973 0.186161 ACOT11 - Acyl-coenzyme A thioesterase 11 precursor - Homo sapiens (Human) - ACOT11 gene Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway. Taurus_UMD|evm.model.AC_000160.1.927 Q5RDY9 F151A_PONAB 77.839 0.930034 1.00171 FAM151A - Protein FAM151A - Pongo abelii (Sumatran orangutan) - FAM151A gene Taurus_UMD|evm.model.AC_000160.1.928 Q8WXI4 ACO11_HUMAN 92.125 0.915825 0.978583 ACOT11 - Acyl-coenzyme A thioesterase 11 precursor - Homo sapiens (Human) - ACOT11 gene Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway. Taurus_UMD|evm.model.AC_000160.1.929 Q9R050 SSBP3_RAT 98.615 0.994475 1.00277 Ssbp3 - Single-stranded DNA-binding protein 3 - Rattus norvegicus (Rat) - Ssbp3 gene May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region. Taurus_UMD|evm.model.AC_000160.1.930 A4FUC0 RM37_BOVIN 100.000 0.995283 1.00236 MRPL37 - 39S ribosomal protein L37, mitochondrial precursor - Bos taurus (Bovine) - MRPL37 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion Taurus_UMD|evm.model.AC_000160.1.931 Q6IPT4 NB5R5_HUMAN 85.099 0.955556 1 CYB5RL - NADH-cytochrome b5 reductase-like - Homo sapiens (Human) - CYB5RL gene NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Taurus_UMD|evm.model.AC_000160.1.932 Q5VXM1 CDCP2_HUMAN 90.591 0.685767 1.2049 CDCP2 - CUB domain-containing protein 2 precursor - Homo sapiens (Human) - CDCP2 gene Taurus_UMD|evm.model.AC_000160.1.933 A5PKE4 TEAN2_BOVIN 99.519 0.990431 1.00481 TCEANC2 - Transcription elongation factor A N-terminal and central domain-containing protein 2 - Bos taurus (Bovine) - TCEANC2 gene Taurus_UMD|evm.model.AC_000160.1.934 Q3T0Q2 TMM59_BOVIN 98.742 0.563055 1.74303 TMEM59 - Transmembrane protein 59 precursor - Bos taurus (Bovine) - TMEM59 gene Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. Taurus_UMD|evm.model.AC_000160.1.935 Q2HJ90 LRC42_BOVIN 100.000 0.995338 1.00234 LRRC42 - Leucine-rich repeat-containing protein 42 - Bos taurus (Bovine) - LRRC42 gene Taurus_UMD|evm.model.AC_000160.1.936 Q9Y547 IFT25_HUMAN 90.210 0.986111 1 HSPB11 - Intraflagellar transport protein 25 homolog - Homo sapiens (Human) - HSPB11 gene Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity). Taurus_UMD|evm.model.AC_000160.1.937 Q6QN13 IOD1_PIG 68.282 0.723577 0.987952 DIO1 - Type I iodothyronine deiodinase - Sus scrofa (Pig) - DIO1 gene Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Taurus_UMD|evm.model.AC_000160.1.938 Q9Y548 YIPF1_HUMAN 91.875 0.97546 0.53268 YIPF1 - Protein YIPF1 - Homo sapiens (Human) - YIPF1 gene Golgi apparatus, Golgi medial cisterna, Golgi trans cisterna, nucleoplasm, plasma membrane, trans-Golgi network, transport vesicle Taurus_UMD|evm.model.AC_000160.1.939 Q5RBL0 YIPF1_PONAB 91.892 0.864706 0.555556 YIPF1 - Protein YIPF1 - Pongo abelii (Sumatran orangutan) - YIPF1 gene Golgi medial cisterna, Golgi trans cisterna, trans-Golgi network Taurus_UMD|evm.model.AC_000160.1.940 Q9BTX1 NDC1_HUMAN 90.963 0.866324 1.1543 NDC1 - Nucleoporin NDC1 - Homo sapiens (Human) - NDC1 gene Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. Taurus_UMD|evm.model.AC_000160.1.941 Q8K1M4 GLIS1_MOUSE 71.277 0.584416 0.195184 Glis1 - Zinc finger protein GLIS1 - Mus musculus (Mouse) - Glis1 gene Acts as both a repressor and activator of transcription (PubMed:12042312, PubMed:12385751, PubMed:21654807). Binds to the consensus sequence 5'-GACCACCCAC-3' (PubMed:12042312). By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807, PubMed:30544251). Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (PubMed:30544251). Taurus_UMD|evm.model.AC_000160.1.942 Q8NBF1 GLIS1_HUMAN 89.516 0.865734 1.15323 GLIS1 - Zinc finger protein GLIS1 - Homo sapiens (Human) - GLIS1 gene Acts as both a repressor and activator of transcription (PubMed:21654807). Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807). Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (By similarity). Taurus_UMD|evm.model.AC_000160.1.944 Q96MA1 DMRTB_HUMAN 60.734 0.910811 1.08187 DMRTB1 - Doublesex- and mab-3-related transcription factor B1 - Homo sapiens (Human) - DMRTB1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, germ cell development, regulation of transcription by RNA polymerase II, sex differentiation Taurus_UMD|evm.model.AC_000160.1.945 Q5R7W2 MPCP_PONAB 82.993 0.885196 0.916898 SLC25A3 - Phosphate carrier protein, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - SLC25A3 gene Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) (By similarity). Taurus_UMD|evm.model.AC_000160.1.946 Q14114 LRP8_HUMAN 92.172 0.923977 0.88785 LRP8 - Low-density lipoprotein receptor-related protein 8 precursor - Homo sapiens (Human) - LRP8 gene Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.947 Q27W02 MGN_RAT 100.000 0.986395 1.00685 Magoh - Protein mago nashi homolog - Rattus norvegicus (Rat) - Magoh gene Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Taurus_UMD|evm.model.AC_000160.1.948 Q32P66 CZIB_BOVIN 99.375 0.987578 1.00625 CZIB - CXXC motif containing zinc binding protein - Bos taurus (Bovine) - CZIB gene zinc ion binding Taurus_UMD|evm.model.AC_000160.1.949 Q2KJB7 CPT2_BOVIN 99.696 0.996965 1.00152 CPT2 - Carnitine O-palmitoyltransferase 2, mitochondrial precursor - Bos taurus (Bovine) - CPT2 gene Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters. Taurus_UMD|evm.model.AC_000160.1.950 O00341 EAA5_HUMAN 93.929 0.972174 1.02679 SLC1A7 - Excitatory amino acid transporter 5 - Homo sapiens (Human) - SLC1A7 gene Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing. Taurus_UMD|evm.model.AC_000160.1.951 Q7Z5L7 PODN_HUMAN 94.425 0.936275 0.998369 PODN - Podocan precursor - Homo sapiens (Human) - PODN gene Negatively regulates cell proliferation and cell migration. Taurus_UMD|evm.model.AC_000160.1.952 P07857 SCP2_BOVIN 87.477 0.995918 0.902394 SCP2 - Sterol carrier protein 2 - Bos taurus (Bovine) - SCP2 gene Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (By similarity). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity). Taurus_UMD|evm.model.AC_000160.1.953 Q2TBT3 ECHD2_BOVIN 100.000 0.609504 1.63514 ECHDC2 - Enoyl-CoA hydratase domain-containing protein 2, mitochondrial precursor - Bos taurus (Bovine) - ECHDC2 gene mitochondrion, enoyl-CoA hydratase activity, fatty acid beta-oxidation Taurus_UMD|evm.model.AC_000160.1.954 Q6WRX3 ZY11A_HUMAN 84.788 0.997358 0.997365 ZYG11A - Protein zyg-11 homolog A - Homo sapiens (Human) - ZYG11A gene Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC. Taurus_UMD|evm.model.AC_000160.1.955 Q9C0D3 ZY11B_HUMAN 99.059 0.997315 1.00134 ZYG11B - Protein zyg-11 homolog B - Homo sapiens (Human) - ZYG11B gene Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZER1 to target substrates bearing N-terminal glycine degrons for proteasomal degradation (PubMed:33093214). Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation (PubMed:31273098). Taurus_UMD|evm.model.AC_000160.1.956 Q921H9 COA7_MOUSE 73.160 0.989189 0.800866 Coa7 - Cytochrome c oxidase assembly factor 7 - Mus musculus (Mouse) - Coa7 gene Required for assembly of mitochondrial respiratory chain complex I and complex IV. Taurus_UMD|evm.model.AC_000160.1.957 Q6UWV7 SHL2A_HUMAN 78.421 0.989418 0.994737 SHISAL2A - Protein shisa-like-2A - Homo sapiens (Human) - SHISAL2A gene Taurus_UMD|evm.model.AC_000160.1.958 A6QLY2 GPX7_BOVIN 100.000 0.989305 1.00538 GPX7 - Glutathione peroxidase 7 precursor - Bos taurus (Bovine) - GPX7 gene endoplasmic reticulum, peroxidase activity Taurus_UMD|evm.model.AC_000160.1.959 Q5TAX3 TUT4_HUMAN 89.448 0.998796 1.01034 TUT4 - Terminal uridylyltransferase 4 - Homo sapiens (Human) - TUT4 gene Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:25979828, PubMed:25480299, PubMed:16643855, PubMed:19703396, PubMed:18172165) (By similarity). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). Taurus_UMD|evm.model.AC_000160.1.960 Q5RDD2 PR38A_PONAB 100.000 0.99361 1.00321 PRPF38A - Pre-mRNA-splicing factor 38A - Pongo abelii (Sumatran orangutan) - PRPF38A gene Involved in pre-mRNA splicing as a component of the spliceosome. Taurus_UMD|evm.model.AC_000160.1.961 Q58DC8 ORC1_BOVIN 99.768 0.997685 1.00116 ORC1 - Origin recognition complex subunit 1 - Bos taurus (Bovine) - ORC1 gene Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Taurus_UMD|evm.model.AC_000160.1.962 Q5T0F9 C2D1B_HUMAN 85.250 0.997664 0.997669 CC2D1B - Coiled-coil and C2 domain-containing protein 1B - Homo sapiens (Human) - CC2D1B gene Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. Taurus_UMD|evm.model.AC_000160.1.963 O95405 ZFYV9_HUMAN 90.316 0.998594 0.997895 ZFYVE9 - Zinc finger FYVE domain-containing protein 9 - Homo sapiens (Human) - ZFYVE9 gene Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. Taurus_UMD|evm.model.AC_000160.1.964 Q2KIY7 BT3L4_BOVIN 97.945 0.326577 2.81013 BTF3L4 - Transcription factor BTF3 homolog 4 - Bos taurus (Bovine) - BTF3L4 gene Taurus_UMD|evm.model.AC_000160.1.965 Q5E936 TXD12_BOVIN 100.000 0.988439 1.00581 TXNDC12 - Thioredoxin domain-containing protein 12 precursor - Bos taurus (Bovine) - TXNDC12 gene Possesses significant protein thiol-disulfide oxidase activity. Taurus_UMD|evm.model.AC_000160.1.966 P10948 RAB3B_BOVIN 81.735 0.98895 0.826484 RAB3B - Ras-related protein Rab-3B - Bos taurus (Bovine) - RAB3B gene Protein transport. Probably involved in vesicular traffic (By similarity). Taurus_UMD|evm.model.AC_000160.1.967 O43847 NRDC_HUMAN 95.886 0.813574 1.01129 NRDC - Nardilysin precursor - Homo sapiens (Human) - NRDC gene Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Taurus_UMD|evm.model.AC_000160.1.968 Q96SU4 OSBL9_HUMAN 94.022 0.997268 0.994565 OSBPL9 - Oxysterol-binding protein-related protein 9 - Homo sapiens (Human) - OSBPL9 gene cytosol, Golgi apparatus, intracellular membrane-bounded organelle, membrane, sterol binding, sterol transporter activity, bile acid biosynthetic process Taurus_UMD|evm.model.AC_000160.1.969 P28491 CALR_PIG 56.250 0.648 0.899281 CALR - Calreticulin precursor - Sus scrofa (Pig) - CALR gene Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (PubMed:20222029). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). Taurus_UMD|evm.model.AC_000160.1.970 P42566 EPS15_HUMAN 93.732 0.975783 0.783482 EPS15 - Epidermal growth factor receptor substrate 15 - Homo sapiens (Human) - EPS15 gene Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. Taurus_UMD|evm.model.AC_000160.1.971 A2ACP1 TT39A_MOUSE 93.440 0.975737 0.99827 Ttc39a - Tetratricopeptide repeat protein 39A - Mus musculus (Mouse) - Ttc39a gene centrosome Taurus_UMD|evm.model.AC_000160.1.972 Q2M2T8 CA185_BOVIN 94.196 0.862348 1.0786 Uncharacterized protein C1orf185 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000160.1.974 P42773 CDN2C_HUMAN 94.048 0.988166 1.00595 CDKN2C - Cyclin-dependent kinase 4 inhibitor C - Homo sapiens (Human) - CDKN2C gene Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Taurus_UMD|evm.model.AC_000160.1.976 A6QQ94 DMTA2_BOVIN 100.000 0.996269 1.00187 DMRTA2 - Doublesex- and mab-3-related transcription factor A2 - Bos taurus (Bovine) - DMRTA2 gene May be involved in sexual development. Taurus_UMD|evm.model.AC_000160.1.977 O09032 ELAV4_RAT 99.474 0.994751 0.98961 Elavl4 - ELAV-like protein 4 - Rattus norvegicus (Rat) - Elavl4 gene RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:10982410, PubMed:16508003, PubMed:17577668). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:10982410, PubMed:16508003, PubMed:17577668). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:10982410). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (By similarity). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (By similarity). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:10982410, PubMed:17577668). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (By similarity). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (PubMed:16508003). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (By similarity). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:10982410, PubMed:17234598). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (PubMed:10982410). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (PubMed:25692578). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (By similarity). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released form ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing (By similarity). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich sequences of CALCA pre-mRNA (By similarity). Taurus_UMD|evm.model.AC_000160.1.978 Q5VU57 CBPC6_HUMAN 98.750 0.9875 0.159046 AGBL4 - Cytosolic carboxypeptidase 6 - Homo sapiens (Human) - AGBL4 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Taurus_UMD|evm.model.AC_000160.1.980 Q2KJG1 SPAT6_BOVIN 93.443 0.995652 0.944559 SPATA6 - Spermatogenesis-associated protein 6 precursor - Bos taurus (Bovine) - SPATA6 gene Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits. Taurus_UMD|evm.model.AC_000160.1.981 Q2M3M2 SC5A9_HUMAN 88.106 0.997067 1.00147 SLC5A9 - Sodium/glucose cotransporter 4 - Homo sapiens (Human) - SLC5A9 gene Involved in sodium-dependent transport of D-mannose, D-glucose and D-fructose. Taurus_UMD|evm.model.AC_000160.1.982 A7XV04 SKIT7_MOUSE 63.291 0.739812 0.807595 Skint7 - Selection and upkeep of intraepithelial T-cells protein 7 precursor - Mus musculus (Mouse) - Skint7 gene May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus. Taurus_UMD|evm.model.AC_000160.1.983 A0A0E4BZH1 SKIT1_MACFA 70.655 0.961433 1.02542 SKINT1 - Selection and upkeep of intraepithelial T-cells protein 1 - Macaca fascicularis (Crab-eating macaque) - SKINT1 gene May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus. Taurus_UMD|evm.model.AC_000160.1.984 A7XUY5 SKIT5_MOUSE 54.000 0.779528 0.0869268 Skint5 - Selection and upkeep of intraepithelial T-cells protein 5 precursor - Mus musculus (Mouse) - Skint5 gene May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus. Taurus_UMD|evm.model.AC_000160.1.986 A6NFA1 TIKI2_HUMAN 89.264 0.95977 1.00967 TRABD2B - Metalloprotease TIKI2 precursor - Homo sapiens (Human) - TRABD2B gene Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. Taurus_UMD|evm.model.AC_000160.1.987 Q63251 FOXD1_RAT 100.000 0.207039 4.78218 Foxd1 - Forkhead box protein D1 - Rattus norvegicus (Rat) - Foxd1 gene Transcription factor involved in regulation of gene expression in a variety of processes including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity). Involved in transcriptional activation of PGF and C3 genes (By similarity). Taurus_UMD|evm.model.AC_000160.1.988 Q9DEN4 FXD3A_XENLA 85.417 0.202586 0.625337 foxd3-a - Forkhead box protein D3-A - Xenopus laevis (African clawed frog) - foxd3-a gene Transcriptional repressor that is an essential upstream regulator of neural crest determination and mesoderm induction. Functions by recruiting the transcriptional corepressor tle4. Also acts in a negative auto-regulator loop by inhibiting the transcription of its own gene. Taurus_UMD|evm.model.AC_000160.1.989 Q2KIW9 KCY_BOVIN 100.000 0.851528 1.16837 CMPK1 - UMP-CMP kinase - Bos taurus (Bovine) - CMPK1 gene Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. Taurus_UMD|evm.model.AC_000160.1.990 Q15468 STIL_HUMAN 82.787 0.492901 0.766123 STIL - SCL-interrupting locus protein - Homo sapiens (Human) - STIL gene Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). Taurus_UMD|evm.model.AC_000160.1.991 P17542 TAL1_HUMAN 93.072 0.993921 0.993958 TAL1 - T-cell acute lymphocytic leukemia protein 1 - Homo sapiens (Human) - TAL1 gene Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). Taurus_UMD|evm.model.AC_000160.1.992 Q2KIP5 PDZ1I_BOVIN 100.000 0.982609 1.00877 PDZK1IP1 - PDZK1-interacting protein 1 - Bos taurus (Bovine) - PDZK1IP1 gene Taurus_UMD|evm.model.AC_000160.1.993 Q8N118 CP4X1_HUMAN 60.079 0.972103 0.915521 CYP4X1 - Cytochrome P450 4X1 - Homo sapiens (Human) - CYP4X1 gene A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Taurus_UMD|evm.model.AC_000160.1.994 P14580 CP4A6_RABIT 80.645 0.782609 0.22549 CYP4A6 - Cytochrome P450 4A6 precursor - Oryctolagus cuniculus (Rabbit) - CYP4A6 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Taurus_UMD|evm.model.AC_000160.1.995 P14579 CP4A5_RABIT 70.000 0.654971 0.334638 CYP4A5 - Cytochrome P450 4A5 precursor - Oryctolagus cuniculus (Rabbit) - CYP4A5 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Taurus_UMD|evm.model.AC_000160.1.996 Q9GJX5 CP4AL_PIG 79.359 0.96699 1.02183 CYP4A21 - Taurochenodeoxycholic 6 alpha-hydroxylase - Sus scrofa (Pig) - CYP4A21 gene Catalyzes the 6 alpha hydroxylation oxidation of taurodeoxycholate to produce the pig specific bile acid taurohyocholic acid. Taurus_UMD|evm.model.AC_000160.1.997 Q9GJX5 CP4AL_PIG 70.315 0.968343 1.06548 CYP4A21 - Taurochenodeoxycholic 6 alpha-hydroxylase - Sus scrofa (Pig) - CYP4A21 gene Catalyzes the 6 alpha hydroxylation oxidation of taurodeoxycholate to produce the pig specific bile acid taurohyocholic acid. Taurus_UMD|evm.model.AC_000160.1.998 Q8SPK0 CP4AP_PIG 40.957 0.811111 0.357143 CYP4A25 - Cytochrome P450 4A25 - Sus scrofa (Pig) - CYP4A25 gene Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Has no activity toward taurochenodeoxycholic acid. Taurus_UMD|evm.model.AC_000160.1.999 Q9GJX5 CP4AL_PIG 74.950 0.955734 0.986111 CYP4A21 - Taurochenodeoxycholic 6 alpha-hydroxylase - Sus scrofa (Pig) - CYP4A21 gene Catalyzes the 6 alpha hydroxylation oxidation of taurodeoxycholate to produce the pig specific bile acid taurohyocholic acid. Taurus_UMD|evm.model.AC_000160.1.1000 P15128 CP4B1_RABIT 83.665 0.978516 1.01186 CYP4B1 - Cytochrome P450 4B1 - Oryctolagus cuniculus (Rabbit) - CYP4B1 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Taurus_UMD|evm.model.AC_000160.1.1001 O75071 EFC14_HUMAN 86.667 0.99596 1 EFCAB14 - EF-hand calcium-binding domain-containing protein 14 - Homo sapiens (Human) - EFCAB14 gene Taurus_UMD|evm.model.AC_000160.1.1002 Q6PEX7 TEX38_HUMAN 73.953 0.990741 1.04854 TEX38 - Testis-expressed protein 38 - Homo sapiens (Human) - TEX38 gene Taurus_UMD|evm.model.AC_000160.1.1003 Q5TC12 ATPF1_HUMAN 93.269 0.884726 1.05793 ATPAF1 - ATP synthase mitochondrial F1 complex assembly factor 1 precursor - Homo sapiens (Human) - ATPAF1 gene May play an essential role for the assembly of the mitochondrial F1-F0 complex. Taurus_UMD|evm.model.AC_000160.1.1004 Q5EAA4 MOB3C_BOVIN 100.000 0.990783 1.00463 MOB3C - MOB kinase activator 3C - Bos taurus (Bovine) - MOB3C gene May regulate the activity of kinases. Taurus_UMD|evm.model.AC_000160.1.1005 Q58D94 MKNK1_BOVIN 99.762 0.995249 1.00238 MKNK1 - MAP kinase-interacting serine/threonine-protein kinase 1 - Bos taurus (Bovine) - MKNK1 gene May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity). Taurus_UMD|evm.model.AC_000160.1.1006 A6PVL3 KNCN_HUMAN 90.816 0.513228 1.52419 KNCN - Kinocilin - Homo sapiens (Human) - KNCN gene May play a role in stabilizing dense microtubular networks or in vesicular trafficking. Taurus_UMD|evm.model.AC_000160.1.1007 A0A0U1RQS6 TM275_HUMAN 73.889 0.988889 1.01695 TMEM275 - Transmembrane protein 275 - Homo sapiens (Human) - TMEM275 gene Taurus_UMD|evm.model.AC_000160.1.1008 Q8NFW5 DMBX1_HUMAN 92.932 0.994667 0.981675 DMBX1 - Diencephalon/mesencephalon homeobox protein 1 - Homo sapiens (Human) - DMBX1 gene Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development (By similarity). Taurus_UMD|evm.model.AC_000160.1.1009 Q90578 VDHAP_CHICK 54.306 0.711604 1.26293 Vitamin D3 hydroxylase-associated protein - Gallus gallus (Chicken) Taurus_UMD|evm.model.AC_000160.1.1010 O00519 FAAH1_HUMAN 85.492 0.996552 1.00173 FAAH - Fatty-acid amide hydrolase 1 - Homo sapiens (Human) - FAAH gene Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:9122178, PubMed:17015445, PubMed:19926788). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:9122178, PubMed:17015445). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:21049984). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity). Taurus_UMD|evm.model.AC_000160.1.1012 Q0V8R7 NSUN4_BOVIN 100.000 0.994805 1.0026 NSUN4 - 5-methylcytosine rRNA methyltransferase NSUN4 precursor - Bos taurus (Bovine) - NSUN4 gene Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4 (By similarity). Taurus_UMD|evm.model.AC_000160.1.1013 P00126 QCR6_BOVIN 100.000 0.978261 1.01099 UQCRH - Cytochrome b-c1 complex subunit 6, mitochondrial precursor - Bos taurus (Bovine) - UQCRH gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Taurus_UMD|evm.model.AC_000160.1.1014 Q8K1C9 LRC41_MOUSE 100.000 0.967213 0.151177 Lrrc41 - Leucine-rich repeat-containing protein 41 - Mus musculus (Mouse) - Lrrc41 gene Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000160.1.1015 Q29RR1 LRC41_BOVIN 99.154 0.918288 0.63145 LRRC41 - Leucine-rich repeat-containing protein 41 - Bos taurus (Bovine) - LRRC41 gene cytoplasm, nucleus Taurus_UMD|evm.model.AC_000160.1.1016 Q29RR1 LRC41_BOVIN 100.000 0.990909 0.27027 LRRC41 - Leucine-rich repeat-containing protein 41 - Bos taurus (Bovine) - LRRC41 gene cytoplasm, nucleus Taurus_UMD|evm.model.AC_000160.1.1017 P70270 RAD54_MOUSE 94.786 0.996 1.00402 Rad54l - DNA repair and recombination protein RAD54-like - Mus musculus (Mouse) - Rad54l gene Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Plays also an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity). Deficiency also resulted in an increased frequency of end-to-end chromosome fusions involving telomeres compared to the controls, suggesting a putative role in telomere capping. Non-homologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. LIG4 and RAD54L cooperate to support cellular proliferation, repair spontaneous DSBs, and prevent chromosome and single chromatid aberrations (PubMed:10209103, PubMed:10757799, PubMed:12218123, PubMed:12531026, PubMed:12548566, PubMed:12897131, PubMed:15175260, PubMed:9108475). Taurus_UMD|evm.model.AC_000160.1.1018 Q96LR2 LURA1_HUMAN 90.795 0.991667 1.00418 LURAP1 - Leucine rich adaptor protein 1 - Homo sapiens (Human) - LURAP1 gene Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity). Taurus_UMD|evm.model.AC_000160.1.1019 Q5EAB6 PMGT1_BOVIN 99.848 0.825815 1.20909 POMGNT1 - Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 - Bos taurus (Bovine) - POMGNT1 gene Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose. Taurus_UMD|evm.model.AC_000160.1.1020 Q3T0S3 TSN1_BOVIN 100.000 0.895522 1.11203 TSPAN1 - Tetraspanin-1 - Bos taurus (Bovine) - TSPAN1 gene integral component of plasma membrane Taurus_UMD|evm.model.AC_000160.1.1021 B1AUF7 P3URF_MOUSE 66.129 0.968254 0.7 P3r3urf - PIK3R3 upstream open reading frame protein - Mus musculus (Mouse) - P3r3urf gene phosphatidylinositol 3-kinase complex, 1-phosphatidylinositol-3-kinase regulator activity, phosphatidylinositol phosphorylation Taurus_UMD|evm.model.AC_000160.1.1022 O46404 P55G_BOVIN 99.296 0.90812 1.01518 PIK3R3 - Phosphatidylinositol 3-kinase regulatory subunit gamma - Bos taurus (Bovine) - PIK3R3 gene Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Taurus_UMD|evm.model.AC_000160.1.1023 Q6P0Q8 MAST2_HUMAN 89.574 0.986142 1.00334 MAST2 - Microtubule-associated serine/threonine-protein kinase 2 - Homo sapiens (Human) - MAST2 gene Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). Taurus_UMD|evm.model.AC_000160.1.1024 Q9Y573 IPP_HUMAN 95.890 0.996581 1.00171 IPP - Actin-binding protein IPP - Homo sapiens (Human) - IPP gene May play a role in organizing the actin cytoskeleton. Taurus_UMD|evm.model.AC_000160.1.1025 Q5R9C3 GPBL1_PONAB 93.882 0.425743 2.34388 GPBP1L1 - Vasculin-like protein 1 - Pongo abelii (Sumatran orangutan) - GPBP1L1 gene Possible transcription factor. Taurus_UMD|evm.model.AC_000160.1.1026 Q2T9P4 NASP_BOVIN 100.000 0.708676 1.40927 NASP - Nuclear autoantigenic sperm protein - Bos taurus (Bovine) - NASP gene Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. Taurus_UMD|evm.model.AC_000160.1.1027 Q5E947 PRDX1_BOVIN 100.000 0.773438 1.28643 PRDX1 - Peroxiredoxin-1 - Bos taurus (Bovine) - PRDX1 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). Taurus_UMD|evm.model.AC_000160.1.1028 Q5E9C8 MMAC_BOVIN 100.000 0.992883 1.00357 MMACHC - Cyanocobalamin reductase / alkylcobalamin dealkylase - Bos taurus (Bovine) - MMACHC gene Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate. Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle. Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether. The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors. Cysteine and homocysteine cannot substitute for glutathione in this reaction. Taurus_UMD|evm.model.AC_000160.1.1029 A0A0D9SF12 CC163_HUMAN 77.778 0.104167 2.31724 CCDC163 - Transmembrane protein CCDC163 - Homo sapiens (Human) - CCDC163 gene Taurus_UMD|evm.model.AC_000160.1.1030 Q96S53 TESK2_HUMAN 91.623 0.996516 1.00525 TESK2 - Dual specificity testis-specific protein kinase 2 - Homo sapiens (Human) - TESK2 gene Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis. Taurus_UMD|evm.model.AC_000160.1.1031 Q17QN2 TOE1_BOVIN 100.000 0.99619 1.00191 TOE1 - Target of EGR1 protein 1 - Bos taurus (Bovine) - TOE1 gene Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing. Taurus_UMD|evm.model.AC_000160.1.1032 Q9UIF7 MUTYH_HUMAN 79.330 0.996205 0.965201 MUTYH - Adenine DNA glycosylase - Homo sapiens (Human) - MUTYH gene Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities. Taurus_UMD|evm.model.AC_000160.1.1033 Q96IR7 HPDL_HUMAN 84.906 0.946292 1.05391 HPDL - 4-hydroxyphenylpyruvate dioxygenase-like protein - Homo sapiens (Human) - HPDL gene May have dioxygenase activity. Taurus_UMD|evm.model.AC_000160.1.1034 Q9P217 ZSWM5_HUMAN 93.694 0.909091 0.10211 ZSWIM5 - Zinc finger SWIM domain-containing protein 5 - Homo sapiens (Human) - ZSWIM5 gene Cul2-RING ubiquitin ligase complex, extracellular space, regulation of axon guidance Taurus_UMD|evm.model.AC_000160.1.1035 Q9P217 ZSWM5_HUMAN 97.374 0.991976 0.84135 ZSWIM5 - Zinc finger SWIM domain-containing protein 5 - Homo sapiens (Human) - ZSWIM5 gene Cul2-RING ubiquitin ligase complex, extracellular space, regulation of axon guidance Taurus_UMD|evm.model.AC_000160.1.1036 Q8HY31 DCUP_SHEEP 99.455 0.994565 1.00272 UROD - Uroporphyrinogen decarboxylase - Ovis aries (Sheep) - UROD gene Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. Taurus_UMD|evm.model.AC_000160.1.1037 Q5T447 HECD3_HUMAN 98.606 0.99768 1.00116 HECTD3 - E3 ubiquitin-protein ligase HECTD3 - Homo sapiens (Human) - HECTD3 gene E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). Taurus_UMD|evm.model.AC_000160.1.1038 A5PJI7 EI2BG_BOVIN 100.000 0.944444 0.318584 EIF2B3 - Translation initiation factor eIF-2B subunit gamma - Bos taurus (Bovine) - EIF2B3 gene Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Taurus_UMD|evm.model.AC_000160.1.1039 P20821 GCSH_BOVIN 85.549 0.9875 0.924855 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Taurus_UMD|evm.model.AC_000160.1.1040 A5PJI7 EI2BG_BOVIN 93.993 0.827893 0.745575 EIF2B3 - Translation initiation factor eIF-2B subunit gamma - Bos taurus (Bovine) - EIF2B3 gene Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Taurus_UMD|evm.model.AC_000160.1.1041 Q9Y6C5 PTC2_HUMAN 90.683 0.998395 1.03574 PTCH2 - Protein patched homolog 2 - Homo sapiens (Human) - PTCH2 gene Plays a role in the control of cellular growth (PubMed:18285427). May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH). Taurus_UMD|evm.model.AC_000160.1.1042 A6QPA3 BTBDJ_BOVIN 100.000 0.993151 1.00344 BTBD19 - BTB/POZ domain-containing protein 19 - Bos taurus (Bovine) - BTBD19 gene Taurus_UMD|evm.model.AC_000160.1.1043 Q4VYA0 DYLT4_PIG 85.388 0.990909 1.00457 DYNLT4 - Dynein light chain Tctex-type 4 - Sus scrofa (Pig) - DYNLT4 gene acrosomal vesicle, axoneme, cytoplasm, microtubule organizing center, nucleus, sperm flagellum, protein phosphatase 1 binding Taurus_UMD|evm.model.AC_000160.1.1044 Q9H4B4 PLK3_HUMAN 92.369 0.969136 1.0031 PLK3 - Serine/threonine-protein kinase PLK3 - Homo sapiens (Human) - PLK3 gene Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. Taurus_UMD|evm.model.AC_000160.1.1045 Q8NFU0 BEST4_HUMAN 90.698 0.995726 0.989429 BEST4 - Bestrophin-4 - Homo sapiens (Human) - BEST4 gene Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Taurus_UMD|evm.model.AC_000160.1.1046 P62243 RS8_RAT 100.000 0.990431 1.00481 Rps8 - 40S ribosomal protein S8 - Rattus norvegicus (Rat) - Rps8 gene cytosolic small ribosomal subunit, ribonucleoprotein complex, structural constituent of ribosome, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000160.1.1047 Q95LP1 KIF2C_MACFA 91.493 0.924033 1.07899 KIF2C - Kinesin-like protein KIF2C - Macaca fascicularis (Crab-eating macaque) - KIF2C gene In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment. Taurus_UMD|evm.model.AC_000160.1.1048 A7MBF6 ARMD1_BOVIN 98.152 0.794118 1.23077 ARMH1 - Armadillo-like helical domain containing protein 1 - Bos taurus (Bovine) - ARMH1 gene Taurus_UMD|evm.model.AC_000160.1.1049 Q2TBP5 TMM53_BOVIN 100.000 0.99322 1.0034 TMEM53 - Transmembrane protein 53 - Bos taurus (Bovine) - TMEM53 gene Taurus_UMD|evm.model.AC_000160.1.1050 Q08DV5 RN220_BOVIN 99.823 0.996473 1.00177 RNF220 - E3 ubiquitin-protein ligase RNF220 - Bos taurus (Bovine) - RNF220 gene E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (By similarity). Taurus_UMD|evm.model.AC_000160.1.1051 A6QLH5 ERI3_BOVIN 100.000 0.992308 0.771513 ERI3 - ERI1 exoribonuclease 3 - Bos taurus (Bovine) - ERI3 gene 3'-5'-exoribonuclease activity, DNA catabolic process, exonucleolytic, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000160.1.1052 Q9NPF5 DMAP1_HUMAN 98.504 0.995736 1.00428 DMAP1 - DNA methyltransferase 1-associated protein 1 - Homo sapiens (Human) - DMAP1 gene Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. Taurus_UMD|evm.model.AC_000160.1.1053 P57054 PIGP_HUMAN 81.818 0.697248 0.689873 PIGP - Phosphatidylinositol N-acetylglucosaminyltransferase subunit P - Homo sapiens (Human) - PIGP gene Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Taurus_UMD|evm.model.AC_000160.1.1054 C7EMF5 KLF17_PIG 59.770 0.232432 0.956072 KLF17 - Krueppel-like factor 17 - Sus scrofa (Pig) - KLF17 gene Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity). Taurus_UMD|evm.model.AC_000160.1.1055 Q5JT82 KLF17_HUMAN 63.953 0.149385 1.46272 KLF17 - Krueppel-like factor 17 - Homo sapiens (Human) - KLF17 gene Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity). Taurus_UMD|evm.model.AC_000160.1.1056 C7EMF5 KLF17_PIG 71.538 0.974937 1.03101 KLF17 - Krueppel-like factor 17 - Sus scrofa (Pig) - KLF17 gene Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity). Taurus_UMD|evm.model.AC_000160.1.1057 Q28039 SC6A9_BOVIN 98.716 0.981073 0.99373 SLC6A9 - Sodium- and chloride-dependent glycine transporter 1 - Bos taurus (Bovine) - SLC6A9 gene Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission (By similarity). Taurus_UMD|evm.model.AC_000160.1.1058 Q8N4L8 CCD24_HUMAN 75.649 0.980769 1.01629 CCDC24 - Coiled-coil domain-containing protein 24 - Homo sapiens (Human) - CCDC24 gene Taurus_UMD|evm.model.AC_000160.1.1059 O60909 B4GT2_HUMAN 95.161 0.994595 0.994624 B4GALT2 - Beta-1,4-galactosyltransferase 2 - Homo sapiens (Human) - B4GALT2 gene Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids (PubMed:9405390). Can produce lactose (PubMed:9405390). Taurus_UMD|evm.model.AC_000160.1.1060 Q2TA24 VATO_BOVIN 100.000 0.990291 1.00488 ATP6V0B - V-type proton ATPase 21 kDa proteolipid subunit - Bos taurus (Bovine) - ATP6V0B gene Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.1061 Q08DM2 DPH2_BOVIN 99.796 0.995918 1.00204 DPH2 - 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 - Bos taurus (Bovine) - DPH2 gene Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). Taurus_UMD|evm.model.AC_000160.1.1062 A7YWD2 IPO13_BOVIN 100.000 0.997925 1.00104 IPO13 - Importin-13 - Bos taurus (Bovine) - IPO13 gene Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 (By similarity). Taurus_UMD|evm.model.AC_000160.1.1063 Q5T4W7 ARTN_HUMAN 94.737 0.831858 0.513636 ARTN - Artemin precursor - Homo sapiens (Human) - ARTN gene Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Taurus_UMD|evm.model.AC_000160.1.1064 P61132 SIAT6_PANTR 98.540 0.954545 0.762667 ST3GAL3 - CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Pan troglodytes (Chimpanzee) - ST3GAL3 gene Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc. Taurus_UMD|evm.model.AC_000160.1.1065 P61132 SIAT6_PANTR 95.714 0.447368 0.405333 ST3GAL3 - CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase - Pan troglodytes (Chimpanzee) - ST3GAL3 gene Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc. Taurus_UMD|evm.model.AC_000160.1.1066 Q5RD88 KDM4A_PONAB 95.314 0.998126 1.00282 KDM4A - Lysine-specific demethylase 4A - Pongo abelii (Sumatran orangutan) - KDM4A gene Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (By similarity). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively (By similarity). Taurus_UMD|evm.model.AC_000160.1.1067 A7MBJ4 PTPRF_BOVIN 99.528 0.998952 1.00527 PTPRF - Receptor-type tyrosine-protein phosphatase F precursor - Bos taurus (Bovine) - PTPRF gene Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity). Taurus_UMD|evm.model.AC_000160.1.1068 Q5T013 HYI_HUMAN 78.853 0.992857 1.01083 HYI - Putative hydroxypyruvate isomerase - Homo sapiens (Human) - HYI gene Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). Taurus_UMD|evm.model.AC_000160.1.1069 Q5T011 SZT2_HUMAN 92.922 0.999417 0.999417 SZT2 - KICSTOR complex protein SZT2 - Homo sapiens (Human) - SZT2 gene As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). Taurus_UMD|evm.model.AC_000160.1.1070 Q9D7W5 MED8_MOUSE 97.388 0.988889 1.00746 Med8 - Mediator of RNA polymerase II transcription subunit 8 - Mus musculus (Mouse) - Med8 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Taurus_UMD|evm.model.AC_000160.1.1071 Q9BW60 ELOV1_HUMAN 92.115 0.88254 1.12903 ELOVL1 - Elongation of very long chain fatty acids protein 1 - Homo sapiens (Human) - ELOVL1 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed:29496980, PubMed:30487246). This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis (PubMed:20937905). Indirectly inhibits RPE65 via production of VLCFAs. Taurus_UMD|evm.model.AC_000160.1.1072 Q5H7C0 CDC20_PIG 98.397 0.996 1.002 CDC20 - Cell division cycle protein 20 homolog - Sus scrofa (Pig) - CDC20 gene Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). Taurus_UMD|evm.model.AC_000160.1.1073 P40931 MPL_MPLV 82.162 0.285271 3.50543 V-MPL - Myeloproliferative leukemia protein - Myeloproliferative leukemia virus (MpLV) - V-MPL gene Truncated form of the receptor for thrombopoietin. Taurus_UMD|evm.model.AC_000160.1.1074 Q06805 TIE1_BOVIN 99.561 0.998246 1.00352 TIE1 - Tyrosine-protein kinase receptor Tie-1 precursor - Bos taurus (Bovine) - TIE1 gene Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. Taurus_UMD|evm.model.AC_000160.1.1075 Q45FY6 HPRT_PIG 94.954 0.990868 1.00459 HPRT1 - Hypoxanthine-guanine phosphoribosyltransferase - Sus scrofa (Pig) - HPRT1 gene Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). Taurus_UMD|evm.model.AC_000160.1.1076 Q8IVY1 CA210_HUMAN 72.566 0.982456 1.00885 C1orf210 - Type III endosome membrane protein TEMP - Homo sapiens (Human) - C1orf210 gene May be involved in membrane trafficking between endosomes and plasma membrane. Taurus_UMD|evm.model.AC_000160.1.1077 Q2HJ59 TM125_BOVIN 100.000 0.990909 1.00457 TMEM125 - Transmembrane protein 125 - Bos taurus (Bovine) - TMEM125 gene Taurus_UMD|evm.model.AC_000160.1.1078 Q9D180 CFA57_MOUSE 60.465 0.976471 0.0680544 Cfap57 - Cilia- and flagella-associated protein 57 - Mus musculus (Mouse) - Cfap57 gene Taurus_UMD|evm.model.AC_000160.1.1079 Q96MR6 CFA57_HUMAN 94.886 0.790909 0.176 CFAP57 - Cilia- and flagella-associated protein 57 - Homo sapiens (Human) - CFAP57 gene Taurus_UMD|evm.model.AC_000160.1.1080 Q5E9Z8 LSM1_BOVIN 92.308 0.0824176 8.21053 LSM1 - U6 snRNA-associated Sm-like protein LSm1 - Bos taurus (Bovine) - LSM1 gene Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). Taurus_UMD|evm.model.AC_000160.1.1081 Q99848 EBP2_HUMAN 89.869 0.993464 1 EBNA1BP2 - Probable rRNA-processing protein EBP2 - Homo sapiens (Human) - EBNA1BP2 gene Required for the processing of the 27S pre-rRNA. Taurus_UMD|evm.model.AC_000160.1.1082 A8QW39 F183A_BOVIN 100.000 0.985294 1.00741 FAM183A - Protein FAM183A - Bos taurus (Bovine) - FAM183A gene ciliary base Taurus_UMD|evm.model.AC_000160.1.1085 O43422 P52K_HUMAN 61.996 0.993737 0.629435 THAP12 - 52 kDa repressor of the inhibitor of the protein kinase - Homo sapiens (Human) - THAP12 gene Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. Taurus_UMD|evm.model.AC_000160.1.1086 B5U6Y8 OXLA_ECHOC 50.403 0.964706 1.0119 L-amino-acid oxidase precursor - Echis ocellatus (Ocellated saw-scaled viper) Taurus_UMD|evm.model.AC_000160.1.1087 Q5RCP8 H2B2E_PONAB 86.400 0.843537 1.16667 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000160.1.1088 P27674 GTR1_BOVIN 100.000 0.995943 1.00203 SLC2A1 - Solute carrier family 2, facilitated glucose transporter member 1 - Bos taurus (Bovine) - SLC2A1 gene Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Taurus_UMD|evm.model.AC_000160.1.1089 Q17QR7 ZN691_BOVIN 99.645 0.992933 1.00355 ZNF691 - Zinc finger protein 691 - Bos taurus (Bovine) - ZNF691 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000160.1.1090 Q96PL5 ERMAP_HUMAN 79.599 0.831933 0.751579 ERMAP - Erythroid membrane-associated protein precursor - Homo sapiens (Human) - ERMAP gene Possible role as a cell-adhesion or receptor molecule of erythroid cells. Taurus_UMD|evm.model.AC_000160.1.1091 Q32LJ0 SVBP_BOVIN 100.000 0.970149 1.01515 SVBP - Small vasohibin-binding protein - Bos taurus (Bovine) - SVBP gene Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. Also required to enhance the solubility and secretion of VASH1 and VASH2. Plays a role in axon and excitatory synapse formation (By similarity). Taurus_UMD|evm.model.AC_000160.1.1092 A0A1B0GVZ9 TM269_HUMAN 76.211 0.904 1.02041 TMEM269 - Transmembrane protein 269 - Homo sapiens (Human) - TMEM269 gene Taurus_UMD|evm.model.AC_000160.1.1093 Q9BV19 CA050_HUMAN 86.294 0.956098 1.03015 C1orf50 - Uncharacterized protein C1orf50 - Homo sapiens (Human) - C1orf50 gene identical protein binding Taurus_UMD|evm.model.AC_000160.1.1094 Q32P28 P3H1_HUMAN 91.168 0.997286 1.00136 P3H1 - Prolyl 3-hydroxylase 1 precursor - Homo sapiens (Human) - P3H1 gene Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. Taurus_UMD|evm.model.AC_000160.1.1095 Q8N6F1 CLD19_HUMAN 95.735 0.990566 0.946429 CLDN19 - Claudin-19 - Homo sapiens (Human) - CLDN19 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Taurus_UMD|evm.model.AC_000160.1.1096 Q9D868 PPIH_MOUSE 100.000 0.237288 3.45213 Ppih - Peptidyl-prolyl cis-trans isomerase H - Mus musculus (Mouse) - Ppih gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. Taurus_UMD|evm.model.AC_000160.1.1097 Q5VVM6 CCD30_HUMAN 69.066 0.660569 1.2567 CCDC30 - Coiled-coil domain-containing protein 30 - Homo sapiens (Human) - CCDC30 gene Taurus_UMD|evm.model.AC_000160.1.1098 Q9HAB8 PPCS_HUMAN 89.389 0.99359 1.00322 PPCS - Phosphopantothenate--cysteine ligase - Homo sapiens (Human) - PPCS gene Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine (PubMed:11923312, PubMed:12906824, PubMed:29754768). Has a preference for ATP over CTP as a cosubstrate (PubMed:11923312). Taurus_UMD|evm.model.AC_000160.1.1099 Q9H0C1 ZMY12_HUMAN 86.066 0.99455 1.00548 ZMYND12 - Zinc finger MYND domain-containing protein 12 - Homo sapiens (Human) - ZMYND12 gene Taurus_UMD|evm.model.AC_000160.1.1100 Q8IXN7 RIMKA_HUMAN 96.419 0.994898 1.00256 RIMKLA - N-acetylaspartylglutamate synthase A - Homo sapiens (Human) - RIMKLA gene Catalyzes the synthesis of N-acetyl-L-aspartyl-L-glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate. Taurus_UMD|evm.model.AC_000160.1.1101 Q9UPW0 FOXJ3_HUMAN 91.520 0.996622 0.951768 FOXJ3 - Forkhead box protein J3 - Homo sapiens (Human) - FOXJ3 gene Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration (By similarity). Plays an important role in spermatogenesis (By similarity). Required for the survival of spermatogonia and participates in spermatocyte meiosis (By similarity). Taurus_UMD|evm.model.AC_000160.1.1102 P79897 GUC2A_PIG 72.321 0.982301 1.0367 GUCA2A - Guanylin precursor - Sus scrofa (Pig) - GUCA2A gene Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. Taurus_UMD|evm.model.AC_000160.1.1103 O13009 GUC2B_PIG 81.416 0.982456 1.00885 GUCA2B - Guanylate cyclase activator 2B precursor - Sus scrofa (Pig) - GUCA2B gene Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity). Taurus_UMD|evm.model.AC_000160.1.1105 Q5T1R4 ZEP3_HUMAN 87.729 0.997911 0.994597 HIVEP3 - Transcription factor HIVEP3 - Homo sapiens (Human) - HIVEP3 gene Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. Taurus_UMD|evm.model.AC_000160.1.1106 Q867A9 EDN2_BOVIN 100.000 0.988764 1.00565 EDN2 - Endothelin-2 precursor - Bos taurus (Bovine) - EDN2 gene Endothelins are endothelium-derived vasoconstrictor peptides. Taurus_UMD|evm.model.AC_000160.1.1108 A8MYZ6 FOXO6_HUMAN 96.711 0.599206 0.512195 FOXO6 - Forkhead box protein O6 - Homo sapiens (Human) - FOXO6 gene Transcriptional activator. Taurus_UMD|evm.model.AC_000160.1.1109 A8MYZ6 FOXO6_HUMAN 97.101 0.925676 0.300813 FOXO6 - Forkhead box protein O6 - Homo sapiens (Human) - FOXO6 gene Transcriptional activator. Taurus_UMD|evm.model.AC_000160.1.1111 Q96GD3 SCMH1_HUMAN 91.732 0.944615 0.984848 SCMH1 - Polycomb protein SCMH1 - Homo sapiens (Human) - SCMH1 gene Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes. Taurus_UMD|evm.model.AC_000160.1.1113 Q8BHW9 SLNL1_MOUSE 68.957 0.984252 0.929268 Slfnl1 - Schlafen-like protein 1 - Mus musculus (Mouse) - Slfnl1 gene Taurus_UMD|evm.model.AC_000160.1.1114 P70698 PYRG1_MOUSE 98.477 0.996622 1.00169 Ctps1 - CTP synthase 1 - Mus musculus (Mouse) - Ctps1 gene This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. Taurus_UMD|evm.model.AC_000160.1.1115 Q9HCK0 ZBT26_HUMAN 90.930 0.995283 0.961451 ZBTB26 - Zinc finger and BTB domain-containing protein 26 - Homo sapiens (Human) - ZBTB26 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000160.1.1116 Q2HJ78 CITE4_BOVIN 100.000 0.989247 1.00541 CITED4 - Cbp/p300-interacting transactivator 4 - Bos taurus (Bovine) - CITED4 gene Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.1117 Q9JK97 KCNQ4_MOUSE 97.293 0.957792 0.885057 Kcnq4 - Potassium voltage-gated channel subfamily KQT member 4 - Mus musculus (Mouse) - Kcnq4 gene Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. Taurus_UMD|evm.model.AC_000160.1.1118 Q5E9X1 NFYC_BOVIN 100.000 0.994048 1.00299 NFYC - Nuclear transcription factor Y subunit gamma - Bos taurus (Bovine) - NFYC gene Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors (By similarity). Taurus_UMD|evm.model.AC_000160.1.1119 Q9UJD0 RIMS3_HUMAN 96.104 0.993528 1.00325 RIMS3 - Regulating synaptic membrane exocytosis protein 3 - Homo sapiens (Human) - RIMS3 gene Regulates synaptic membrane exocytosis. Taurus_UMD|evm.model.AC_000160.1.1120 P13984 T2FB_HUMAN 69.620 0.914729 1.03614 GTF2F2 - General transcription factor IIF subunit 2 - Homo sapiens (Human) - GTF2F2 gene TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. Taurus_UMD|evm.model.AC_000160.1.1121 Q4R6J4 ZN684_MACFA 81.627 0.992167 1.01323 ZNF684 - Zinc finger protein 684 - Macaca fascicularis (Crab-eating macaque) - ZNF684 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000160.1.1122 A2VDX7 EXO5_BOVIN 100.000 0.61194 1.62973 EXO5 - Exonuclease V - Bos taurus (Bovine) - EXO5 gene Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity (By similarity). Taurus_UMD|evm.model.AC_000160.1.1123 Q9UJL9 ZF69B_HUMAN 81.775 0.995157 0.773408 ZFP69B - Zinc finger protein 69 homolog B - Homo sapiens (Human) - ZFP69B gene May be involved in transcriptional regulation. Essential for Golgi structural integrity (PubMed:29851555). Taurus_UMD|evm.model.AC_000160.1.1124 P61515 RL37P_RAT 67.606 0.811765 0.923913 Rpl37a-ps1 - Putative 60S ribosomal protein L37a - Rattus norvegicus (Rat) - Rpl37a-ps1 gene Taurus_UMD|evm.model.AC_000160.1.1125 Q5EA00 SMAP2_BOVIN 100.000 0.995349 1.00233 SMAP2 - Stromal membrane-associated protein 2 - Bos taurus (Bovine) - SMAP2 gene GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity). Taurus_UMD|evm.model.AC_000160.1.1126 C0HLN2 CO9A2_BOVIN 94.477 0.996928 0.946221 COL9A2 - Collagen alpha-2(IX) chain precursor - Bos taurus (Bovine) - COL9A2 gene Structural component of hyaline cartilage and vitreous of the eye. Taurus_UMD|evm.model.AC_000160.1.1127 O75844 FACE1_HUMAN 96.835 0.993697 1.00211 ZMPSTE24 - CAAX prenyl protease 1 homolog - Homo sapiens (Human) - ZMPSTE24 gene Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C. Taurus_UMD|evm.model.AC_000160.1.1128 P84100 RL19_RAT 51.531 0.984962 0.678571 Rpl19 - 60S ribosomal protein L19 - Rattus norvegicus (Rat) - Rpl19 gene cytosolic large ribosomal subunit, polysomal ribosome, synapse, 5.8S rRNA binding, large ribosomal subunit rRNA binding, RNA binding, structural constituent of ribosome, cytoplasmic translation, liver regeneration Taurus_UMD|evm.model.AC_000160.1.1129 Q2NKV5 TMCO2_BOVIN 100.000 0.989071 1.00549 TMCO2 - Transmembrane and coiled-coil domain-containing protein 2 - Bos taurus (Bovine) - TMCO2 gene Taurus_UMD|evm.model.AC_000160.1.1130 Q13129 RLF_HUMAN 94.024 0.985886 0.999478 RLF - Zinc finger protein Rlf - Homo sapiens (Human) - RLF gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000160.1.1131 P45478 PPT1_BOVIN 99.673 0.993485 1.00327 PPT1 - Palmitoyl-protein thioesterase 1 precursor - Bos taurus (Bovine) - PPT1 gene Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. Taurus_UMD|evm.model.AC_000160.1.1132 Q3SYV4 CAP1_BOVIN 99.788 0.995763 1 CAP1 - Adenylyl cyclase-associated protein 1 - Bos taurus (Bovine) - CAP1 gene Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. Taurus_UMD|evm.model.AC_000160.1.1133 Q9DA75 NLS1_MOUSE 87.828 0.99619 0.983146 Mfsd2a - Sodium-dependent lysophosphatidylcholine symporter 1 - Mus musculus (Mouse) - Mfsd2a gene Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (PubMed:24828044, PubMed:24828040). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid (PubMed:24828044). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis (PubMed:24828040). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. Taurus_UMD|evm.model.AC_000160.1.1134 P12524 MYCL_HUMAN 90.934 0.918987 1.08516 MYCL - Protein L-Myc - Homo sapiens (Human) - MYCL gene chromatin, chromosome, nucleoplasm, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000160.1.1135 Q9H3H1 MOD5_HUMAN 88.211 0.995798 1.01927 TRIT1 - tRNA dimethylallyltransferase precursor - Homo sapiens (Human) - TRIT1 gene Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). Taurus_UMD|evm.model.AC_000160.1.1136 Q08DE5 EI24_BOVIN 96.535 0.897321 0.658824 EI24 - Etoposide-induced protein 2.4 homolog - Bos taurus (Bovine) - EI24 gene Taurus_UMD|evm.model.AC_000160.1.1137 P34820 BMP8B_HUMAN 88.396 0.979866 0.741294 BMP8B - Bone morphogenetic protein 8B precursor - Homo sapiens (Human) - BMP8B gene Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Taurus_UMD|evm.model.AC_000160.1.1138 A4FV72 PPIE_BOVIN 99.668 0.993377 1.00332 PPIE - Peptidyl-prolyl cis-trans isomerase E - Bos taurus (Bovine) - PPIE gene Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity. Taurus_UMD|evm.model.AC_000160.1.1139 Q5R6S5 HPCL4_PONAB 100.000 0.766129 1.29843 HPCAL4 - Hippocalcin-like protein 4 - Pongo abelii (Sumatran orangutan) - HPCAL4 gene May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Taurus_UMD|evm.model.AC_000160.1.1140 Q9BXI3 5NT1A_HUMAN 95.109 0.994536 0.994565 NT5C1A - Cytosolic 5'-nucleotidase 1A - Homo sapiens (Human) - NT5C1A gene Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia. Taurus_UMD|evm.model.AC_000160.1.1141 Q2NL18 HEYL_BOVIN 100.000 0.990909 1.0061 HEYL - Hairy/enhancer-of-split related with YRPW motif-like protein - Bos taurus (Bovine) - HEYL gene Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Taurus_UMD|evm.model.AC_000160.1.1142 Q13310 PABP4_HUMAN 96.472 0.797794 1.26708 PABPC4 - Polyadenylate-binding protein 4 - Homo sapiens (Human) - PABPC4 gene Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). Taurus_UMD|evm.model.AC_000160.1.1143 P34820 BMP8B_HUMAN 88.333 0.610922 0.728856 BMP8B - Bone morphogenetic protein 8B precursor - Homo sapiens (Human) - BMP8B gene Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Taurus_UMD|evm.model.AC_000160.1.1145 D3ZHV2 MACF1_RAT 91.316 0.201509 1.36722 Macf1 - Microtubule-actin cross-linking factor 1 - Rattus norvegicus (Rat) - Macf1 gene F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (By similarity). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (By similarity). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). Taurus_UMD|evm.model.AC_000160.1.1146 Q9UPN3 MACF1_HUMAN 100.000 0.911392 0.010693 MACF1 - Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 - Homo sapiens (Human) - MACF1 gene F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). Taurus_UMD|evm.model.AC_000160.1.1148 Q02379 NDUS5_BOVIN 100.000 0.981308 1.00943 NDUFS5 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 - Bos taurus (Bovine) - NDUFS5 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000160.1.1149 Q9H9L7 AKIR1_HUMAN 95.312 0.989637 1.00521 AKIRIN1 - Akirin-1 - Homo sapiens (Human) - AKIRIN1 gene Functions as signal transducer for MSTN during skeletal muscle regeneration and myogenesis. May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway. Taurus_UMD|evm.model.AC_000160.1.1150 A2AGA4 RHBL2_MOUSE 85.149 0.993421 1.00662 Rhbdl2 - Rhomboid-related protein 2 - Mus musculus (Mouse) - Rhbdl2 gene Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3 (By similarity). Taurus_UMD|evm.model.AC_000160.1.1151 P57773 CXA9_HUMAN 79.457 0.996109 0.998058 GJA9 - Gap junction alpha-9 protein - Homo sapiens (Human) - GJA9 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Taurus_UMD|evm.model.AC_000160.1.1152 Q2TBP7 MYCBP_BOVIN 100.000 0.80315 1.23301 MYCBP - c-Myc-binding protein - Bos taurus (Bovine) - MYCBP gene May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC (By similarity). Taurus_UMD|evm.model.AC_000160.1.1153 Q9HB90 RRAGC_HUMAN 99.248 0.995 1.00251 RRAGC - Ras-related GTP-binding protein C - Homo sapiens (Human) - RRAGC gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:27234373, PubMed:24095279). Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form (PubMed:24095279). In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:27234373, PubMed:24095279). This is a crucial step in the activation of the TOR signaling cascade by amino acids (PubMed:20381137, PubMed:27234373, PubMed:24095279). Taurus_UMD|evm.model.AC_000160.1.1155 P20267 PO3F1_RAT 99.512 0.832994 1.08869 Pou3f1 - POU domain, class 3, transcription factor 1 - Rattus norvegicus (Rat) - Pou3f1 gene Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). Acts as a transcriptional repressor of myelin-specific genes (PubMed:1975954). Taurus_UMD|evm.model.AC_000160.1.1156 Q9Y3A2 UTP11_HUMAN 94.862 0.992126 1.00395 UTP11 - Probable U3 small nucleolar RNA-associated protein 11 - Homo sapiens (Human) - UTP11 gene Involved in nucleolar processing of pre-18S ribosomal RNA. Taurus_UMD|evm.model.AC_000160.1.1157 Q3ZBI6 FHL3_BOVIN 100.000 0.992883 1.00357 FHL3 - Four and a half LIM domains protein 3 - Bos taurus (Bovine) - FHL3 gene Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1. Taurus_UMD|evm.model.AC_000160.1.1158 Q12874 SF3A3_HUMAN 99.601 0.996016 1.002 SF3A3 - Splicing factor 3A subunit 3 - Homo sapiens (Human) - SF3A3 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:8022796, PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). Taurus_UMD|evm.model.AC_000160.1.1159 P32019 I5P2_HUMAN 81.662 0.85524 1.13394 INPP5B - Type II inositol 1,4,5-trisphosphate 5-phosphatase precursor - Homo sapiens (Human) - INPP5B gene Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. Taurus_UMD|evm.model.AC_000160.1.1160 Q14872 MTF1_HUMAN 91.102 0.99734 0.998672 MTF1 - Metal regulatory transcription factor 1 - Homo sapiens (Human) - MTF1 gene Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity). Taurus_UMD|evm.model.AC_000160.1.1161 Q6ZSJ8 CA122_HUMAN 96.364 0.981982 1.00909 C1orf122 - Uncharacterized protein C1orf122 - Homo sapiens (Human) - C1orf122 gene Taurus_UMD|evm.model.AC_000160.1.1162 Q0VC80 YRDC_BOVIN 100.000 0.99278 1.00362 YRDC - YrdC domain-containing protein, mitochondrial precursor - Bos taurus (Bovine) - YRDC gene May regulate the activity of some transporters. Taurus_UMD|evm.model.AC_000160.1.1163 Q5VSG8 MANEL_HUMAN 99.088 0.993939 0.722101 MANEAL - Glycoprotein endo-alpha-1,2-mannosidase-like protein - Homo sapiens (Human) - MANEAL gene Golgi apparatus, alpha-mannosidase activity Taurus_UMD|evm.model.AC_000160.1.1164 Q5JZY3 EPHAA_HUMAN 93.849 0.998018 1.00099 EPHA10 - Ephrin type-A receptor 10 precursor - Homo sapiens (Human) - EPHA10 gene Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5. Taurus_UMD|evm.model.AC_000160.1.1165 Q5RBS5 BOREA_PONAB 87.189 0.992883 1.00357 Taurus_UMD|evm.model.AC_000160.1.1166 Q9NX04 CA109_HUMAN 82.075 0.99061 1.04926 C1orf109 - Uncharacterized protein C1orf109 - Homo sapiens (Human) - C1orf109 gene May promote cancer cell proliferation by controlling the G1 to S phase transition. Taurus_UMD|evm.model.AC_000160.1.1167 Q2MKA7 RSPO1_HUMAN 88.973 0.992395 1 RSPO1 - R-spondin-1 precursor - Homo sapiens (Human) - RSPO1 gene Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805). Taurus_UMD|evm.model.AC_000160.1.1168 Q13823 NOG2_HUMAN 87.193 0.997271 1.00274 GNL2 - Nucleolar GTP-binding protein 2 - Homo sapiens (Human) - GNL2 gene GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). Taurus_UMD|evm.model.AC_000160.1.1169 O14645 IDLC_HUMAN 98.062 0.992278 1.00388 DNALI1 - Axonemal dynein light intermediate polypeptide 1 - Homo sapiens (Human) - DNALI1 gene May play a dynamic role in flagellar motility. Taurus_UMD|evm.model.AC_000160.1.1170 Q8TAD8 SNIP1_HUMAN 87.469 0.995 1.0101 SNIP1 - Smad nuclear-interacting protein 1 - Homo sapiens (Human) - SNIP1 gene Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Taurus_UMD|evm.model.AC_000160.1.1171 Q58CU0 EAF6_BOVIN 100.000 0.989583 1.00524 MEAF6 - Chromatin modification-related protein MEAF6 - Bos taurus (Bovine) - MEAF6 gene Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Taurus_UMD|evm.model.AC_000160.1.1172 A6QQJ8 ZC12A_BOVIN 100.000 0.996575 1.00172 ZC3H12A - Ribonuclease ZC3H12A - Bos taurus (Bovine) - ZC3H12A gene Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Self regulates by destabilizing its own mRNA. Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (By similarity). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (By similarity). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (By similarity). Plays also a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (By similarity). Affects the overall ubiquitination of cellular proteins. Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (By similarity). Prevents stress granules (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock, and energy deprivation. Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state. May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (By similarity). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (By similarity). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial proinflammatory cytokine production (By similarity). Taurus_UMD|evm.model.AC_000160.1.1173 Q38PU2 GRIK3_MACFA 97.368 0.506849 0.0794342 GRIK3 - Glutamate receptor ionotropic, kainate 3 precursor - Macaca fascicularis (Crab-eating macaque) - GRIK3 gene Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA (By similarity). Taurus_UMD|evm.model.AC_000160.1.1174 Q38PU2 GRIK3_MACFA 99.308 0.997696 0.944505 GRIK3 - Glutamate receptor ionotropic, kainate 3 precursor - Macaca fascicularis (Crab-eating macaque) - GRIK3 gene Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA (By similarity). Taurus_UMD|evm.model.AC_000160.1.1178 Q99062 CSF3R_HUMAN 73.841 0.997622 1.00598 CSF3R - Granulocyte colony-stimulating factor receptor precursor - Homo sapiens (Human) - CSF3R gene Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. Taurus_UMD|evm.model.AC_000160.1.1179 P82913 RT15_BOVIN 98.842 0.992308 1.01562 MRPS15 - 28S ribosomal protein S15, mitochondrial precursor - Bos taurus (Bovine) - MRPS15 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000160.1.1180 Q29S00 OSCP1_BOVIN 100.000 0.841871 1.1847 OSCP1 - Protein OSCP1 - Bos taurus (Bovine) - OSCP1 gene May be involved in drug clearance in the placenta. Taurus_UMD|evm.model.AC_000160.1.1181 Q8QZX5 LSM10_MOUSE 90.833 0.704142 1.38525 Lsm10 - U7 snRNA-associated Sm-like protein LSm10 - Mus musculus (Mouse) - Lsm10 gene Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (By similarity). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to U7 snRNA (By similarity). Binds specifically to U7 snRNA (By similarity). Binds to the downstream cleavage product (DCP) of histone pre-mRNA. Taurus_UMD|evm.model.AC_000160.1.1182 Q17QV9 STK40_BOVIN 100.000 0.995423 1.00229 STK40 - Serine/threonine-protein kinase 40 - Bos taurus (Bovine) - STK40 gene May be a negative regulator of NF-kappa-B and p53-mediated gene transcription. Taurus_UMD|evm.model.AC_000160.1.1183 Q9NVM1 EVA1B_HUMAN 92.857 0.988166 1.02424 EVA1B - Protein eva-1 homolog B - Homo sapiens (Human) - EVA1B gene Taurus_UMD|evm.model.AC_000160.1.1184 Q4R729 SH321_MACFA 56.327 0.57874 1.10116 SH3D21 - SH3 domain-containing protein 21 - Macaca fascicularis (Crab-eating macaque) - SH3D21 gene Taurus_UMD|evm.model.AC_000160.1.1185 Q9Y2W1 TR150_HUMAN 96.663 0.997912 1.00314 THRAP3 - Thyroid hormone receptor-associated protein 3 - Homo sapiens (Human) - THRAP3 gene Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). Taurus_UMD|evm.model.AC_000160.1.1187 Q3KQU3 MA7D1_HUMAN 84.525 0.997546 0.969084 MAP7D1 - MAP7 domain-containing protein 1 - Homo sapiens (Human) - MAP7D1 gene cytosol, microtubule cytoskeleton, microtubule cytoskeleton organization Taurus_UMD|evm.model.AC_000160.1.1188 O43617 TPPC3_HUMAN 99.444 0.98895 1.00556 TRAPPC3 - Trafficking protein particle complex subunit 3 - Homo sapiens (Human) - TRAPPC3 gene May play a role in vesicular transport from endoplasmic reticulum to Golgi. Taurus_UMD|evm.model.AC_000160.1.1189 P25067 CO8A2_HUMAN 95.022 0.967376 1.00284 COL8A2 - Collagen alpha-2(VIII) chain precursor - Homo sapiens (Human) - COL8A2 gene Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). Taurus_UMD|evm.model.AC_000160.1.1190 Q3SYV9 ADPRS_BOVIN 99.726 0.994536 1.00274 ADPRS - ADP-ribose glycohydrolase ARH3 - Bos taurus (Bovine) - ADPRS gene ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos. Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers. Taurus_UMD|evm.model.AC_000160.1.1191 Q2T9Q6 TEKT2_BOVIN 100.000 0.99536 1.00233 TEKT2 - Tektin-2 - Bos taurus (Bovine) - TEKT2 gene Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Taurus_UMD|evm.model.AC_000160.1.1193 Q9H9G7 AGO3_HUMAN 99.884 0.997677 1.00116 AGO3 - Protein argonaute-3 - Homo sapiens (Human) - AGO3 gene Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713). Taurus_UMD|evm.model.AC_000160.1.1194 Q8CJG1 AGO1_MOUSE 99.416 0.967195 1.03151 Ago1 - Protein argonaute-1 - Mus musculus (Mouse) - Ago1 gene Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. May also be required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). Taurus_UMD|evm.model.AC_000160.1.1195 Q9HCK5 AGO4_HUMAN 99.535 0.99768 1.00116 AGO4 - Protein argonaute-4 - Homo sapiens (Human) - AGO4 gene Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). Taurus_UMD|evm.model.AC_000160.1.1196 Q9HAW4 CLSPN_HUMAN 82.861 0.952177 1.0463 CLSPN - Claspin - Homo sapiens (Human) - CLSPN gene Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. Taurus_UMD|evm.model.AC_000160.1.1197 Q8TAB5 CA216_HUMAN 84.649 0.986842 0.995633 C1orf216 - UPF0500 protein C1orf216 - Homo sapiens (Human) - C1orf216 gene Taurus_UMD|evm.model.AC_000160.1.1198 Q5E9K0 PSB2_BOVIN 88.557 0.989189 0.920398 PSMB2 - Proteasome subunit beta type-2 - Bos taurus (Bovine) - PSMB2 gene Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Taurus_UMD|evm.model.AC_000160.1.1199 Q6VUC0 AP2E_HUMAN 95.485 0.995465 0.997738 TFAP2E - Transcription factor AP-2-epsilon - Homo sapiens (Human) - TFAP2E gene Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). Taurus_UMD|evm.model.AC_000160.1.1200 Q2KJ97 NCDN_BOVIN 100.000 0.99726 1.00137 NCDN - Neurochondrin - Bos taurus (Bovine) - NCDN gene Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (By similarity). Taurus_UMD|evm.model.AC_000160.1.1202 Q8IZA0 K319L_HUMAN 88.476 0.998084 0.995234 KIAA0319L - Dyslexia-associated protein KIAA0319-like protein - Homo sapiens (Human) - KIAA0319L gene Possible role in axon guidance through interaction with RTN4R. Taurus_UMD|evm.model.AC_000160.1.1203 Q5VZL5 ZMYM4_HUMAN 97.226 0.998711 1.00194 ZMYM4 - Zinc finger MYM-type protein 4 - Homo sapiens (Human) - ZMYM4 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Taurus_UMD|evm.model.AC_000160.1.1204 Q8VIJ6 SFPQ_MOUSE 98.954 0.673729 1.01288 Sfpq - Splicing factor, proline- and glutamine-rich - Mus musculus (Mouse) - Sfpq gene DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as transcriptional activator (By similarity). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (PubMed:21680841, PubMed:22966205). Required for the assembly of nuclear speckles (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity). Taurus_UMD|evm.model.AC_000160.1.1205 Q5SVZ6 ZMYM1_HUMAN 78.858 0.990099 0.972855 ZMYM1 - Zinc finger MYM-type protein 1 - Homo sapiens (Human) - ZMYM1 gene Taurus_UMD|evm.model.AC_000160.1.1206 O95789 ZMYM6_HUMAN 86.360 0.998486 0.996981 ZMYM6 - Zinc finger MYM-type protein 6 - Homo sapiens (Human) - ZMYM6 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Taurus_UMD|evm.model.AC_000160.1.1207 Q8NCS4 TM35B_HUMAN 82.569 0.837209 0.837662 TMEM35B - Transmembrane protein 35B precursor - Homo sapiens (Human) - TMEM35B gene Taurus_UMD|evm.model.AC_000160.1.1208 Q7L0L9 YA043_HUMAN 77.228 0.426009 1.02294 Transmembrane protein LOC653160 - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000160.1.1209 O95886 DLGP3_HUMAN 94.995 0.997914 0.979571 DLGAP3 - Disks large-associated protein 3 - Homo sapiens (Human) - DLGAP3 gene May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Taurus_UMD|evm.model.AC_000160.1.1210 F6USH3 SIM12_HORSE 100.000 0.938144 1.05435 SMIM12 - Small integral membrane protein 12 - Equus caballus (Horse) - SMIM12 gene Taurus_UMD|evm.model.AC_000160.1.1211 A4IFL1 CXA4_BOVIN 100.000 0.966216 0.888889 GJA4 - Gap junction alpha-4 protein - Bos taurus (Bovine) - GJA4 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Taurus_UMD|evm.model.AC_000160.1.1212 Q58D78 CXB3_BOVIN 100.000 0.99262 1.0037 GJB3 - Gap junction beta-3 protein - Bos taurus (Bovine) - GJB3 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Taurus_UMD|evm.model.AC_000160.1.1213 Q9NTQ9 CXB4_HUMAN 82.707 0.992509 1.00376 GJB4 - Gap junction beta-4 protein - Homo sapiens (Human) - GJB4 gene Structural component of gap junctions (By similarity). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (By similarity). Taurus_UMD|evm.model.AC_000160.1.1214 O95377 CXB5_HUMAN 80.952 0.992701 1.00366 GJB5 - Gap junction beta-5 protein - Homo sapiens (Human) - GJB5 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Taurus_UMD|evm.model.AC_000160.1.1216 Q6P1W5 CA094_HUMAN 77.038 0.996678 1.00669 C1orf94 - Uncharacterized protein C1orf94 - Homo sapiens (Human) - C1orf94 gene Taurus_UMD|evm.model.AC_000160.1.1218 Q7Z408 CSMD2_HUMAN 94.667 0.778947 0.027244 CSMD2 - CUB and sushi domain-containing protein 2 - Homo sapiens (Human) - CSMD2 gene Taurus_UMD|evm.model.AC_000160.1.1219 Q7Z408 CSMD2_HUMAN 91.781 0.775401 0.0536278 CSMD2 - CUB and sushi domain-containing protein 2 - Homo sapiens (Human) - CSMD2 gene Taurus_UMD|evm.model.AC_000160.1.1220 Q32L34 HMGB4_BOVIN 100.000 0.989744 1.00515 HMGB4 - High mobility group protein B4 - Bos taurus (Bovine) - HMGB4 gene DNA binding, bending, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000160.1.1221 Q7Z408 CSMD2_HUMAN 98.701 0.761787 0.115572 CSMD2 - CUB and sushi domain-containing protein 2 - Homo sapiens (Human) - CSMD2 gene Taurus_UMD|evm.model.AC_000160.1.1222 Q7Z408 CSMD2_HUMAN 83.681 0.869666 0.866934 CSMD2 - CUB and sushi domain-containing protein 2 - Homo sapiens (Human) - CSMD2 gene Taurus_UMD|evm.model.AC_000160.1.1223 Q5R893 H2B1_PONAB 84.800 0.909091 0.960317 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000160.1.1224 P17040 ZSC20_HUMAN 81.897 0.985795 1.01246 ZSCAN20 - Zinc finger and SCAN domain-containing protein 20 - Homo sapiens (Human) - ZSCAN20 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000160.1.1225 Q17QM6 EFHD1_BOVIN 100.000 0.991561 1.00424 EFHD1 - EF-hand domain-containing protein D1 - Bos taurus (Bovine) - EFHD1 gene Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (By similarity). May play a role in neuronal differentiation (By similarity). Taurus_UMD|evm.model.AC_000160.1.1226 Q6Y7W6 GGYF2_HUMAN 95.381 0.998452 0.994611 GIGYF2 - GRB10-interacting GYF protein 2 - Homo sapiens (Human) - GIGYF2 gene Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). Taurus_UMD|evm.model.AC_000160.1.1227 Q6UX34 SNORC_HUMAN 86.777 0.983607 1.00826 SNORC - Protein SNORC precursor - Homo sapiens (Human) - SNORC gene Plays a role in the regulation of chondrocyte maturation and postnatal endochondral ossification. May inhibit cell growth stimulation induced by FGF2. Taurus_UMD|evm.model.AC_000160.1.1228 Q8N5V2 NGEF_HUMAN 88.922 0.994012 0.940845 NGEF - Ephexin-1 - Homo sapiens (Human) - NGEF gene Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). Taurus_UMD|evm.model.AC_000160.1.1229 Q9Y3R4 NEUR2_HUMAN 72.368 0.994737 1 NEU2 - Sialidase-2 - Homo sapiens (Human) - NEU2 gene Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides (PubMed:14613940, PubMed:22228546). Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form (PubMed:14613940). Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues (PubMed:14613940). Taurus_UMD|evm.model.AC_000160.1.1230 Q92835 SHIP1_HUMAN 88.289 0.998326 1.00505 INPP5D - Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 - Homo sapiens (Human) - INPP5D gene Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:8723348, PubMed:10764818, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:9108392, PubMed:10764818, PubMed:8769125). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. Taurus_UMD|evm.model.AC_000160.1.1232 Q676U5 A16L1_HUMAN 94.069 0.996711 1.00165 ATG16L1 - Autophagy-related protein 16-1 - Homo sapiens (Human) - ATG16L1 gene Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). Taurus_UMD|evm.model.AC_000160.1.1234 P08168 ARRS_BOVIN 100.000 0.995062 1.00248 SAG - S-arrestin - Bos taurus (Bovine) - SAG gene Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (PubMed:8003967, PubMed:25205354). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (By similarity). Taurus_UMD|evm.model.AC_000160.1.1235 Q16760 DGKD_HUMAN 92.618 0.904355 1.05931 DGKD - Diacylglycerol kinase delta - Homo sapiens (Human) - DGKD gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). Taurus_UMD|evm.model.AC_000160.1.1236 Q9NVE5 UBP40_HUMAN 83.738 0.998379 0.99919 USP40 - Ubiquitin carboxyl-terminal hydrolase 40 - Homo sapiens (Human) - USP40 gene May be catalytically inactive. Taurus_UMD|evm.model.AC_000160.1.1237 P19224 UD16_HUMAN 80.077 0.637824 1.52068 UGT1A6 - UDP-glucuronosyltransferase 1-6 precursor - Homo sapiens (Human) - UGT1A6 gene UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). Taurus_UMD|evm.model.AC_000160.1.1238 A6NES4 MRO2A_HUMAN 81.526 0.983558 1.01732 MROH2A - Maestro heat-like repeat-containing protein family member 2A - Homo sapiens (Human) - MROH2A gene Taurus_UMD|evm.model.AC_000160.1.1239 D3Z750 MRO2A_MOUSE 70.909 0.574713 0.0518166 Mroh2a - Maestro heat-like repeat-containing protein family member 2A - Mus musculus (Mouse) - Mroh2a gene Taurus_UMD|evm.model.AC_000160.1.1240 D3Z750 MRO2A_MOUSE 82.587 0.632107 0.178082 Mroh2a - Maestro heat-like repeat-containing protein family member 2A - Mus musculus (Mouse) - Mroh2a gene Taurus_UMD|evm.model.AC_000160.1.1241 Q8NCD3 HJURP_HUMAN 55.508 0.992847 0.934492 HJURP - Holliday junction recognition protein - Homo sapiens (Human) - HJURP gene Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. Taurus_UMD|evm.model.AC_000160.1.1242 Q7Z2W7 TRPM8_HUMAN 93.904 0.979483 1.0154 TRPM8 - Transient receptor potential cation channel subfamily M member 8 - Homo sapiens (Human) - TRPM8 gene Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel. Taurus_UMD|evm.model.AC_000160.1.1243 Q27967 SPP24_BOVIN 100.000 0.990196 1.00493 SPP2 - Secreted phosphoprotein 24 precursor - Bos taurus (Bovine) - SPP2 gene Could coordinate an aspect of bone turnover. Taurus_UMD|evm.model.AC_000160.1.1244 P61208 ARL4C_MOUSE 100.000 0.989637 1.00521 Arl4c - ADP-ribosylation factor-like protein 4C - Mus musculus (Mouse) - Arl4c gene Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process (By similarity). Taurus_UMD|evm.model.AC_000160.1.1247 Q9P0V3 SH3B4_HUMAN 91.900 0.997925 1.00104 SH3BP4 - SH3 domain-binding protein 4 - Homo sapiens (Human) - SH3BP4 gene May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. Taurus_UMD|evm.model.AC_000160.1.1249 P52951 GBX2_HUMAN 98.281 0.994286 1.00575 GBX2 - Homeobox protein GBX-2 - Homo sapiens (Human) - GBX2 gene May act as a transcription factor for cell pluripotency and differentiation in the embryo. Taurus_UMD|evm.model.AC_000160.1.1250 Q6ZVZ8 ASB18_HUMAN 84.335 0.995717 1.00215 ASB18 - Ankyrin repeat and SOCS box protein 18 - Homo sapiens (Human) - ASB18 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000160.1.1251 Q86XH1 DRC11_HUMAN 89.333 0.199732 0.907543 IQCA1 - Dynein regulatory complex protein 11 - Homo sapiens (Human) - IQCA1 gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Taurus_UMD|evm.model.AC_000160.1.1252 P11613 ACKR3_CANLF 92.265 0.99449 1.00276 ACKR3 - Atypical chemokine receptor 3 - Canis lupus familiaris (Dog) - ACKR3 gene Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development (By similarity). Taurus_UMD|evm.model.AC_000160.1.1253 Q32L59 TMC5B_BOVIN 86.364 0.111399 1.09972 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Taurus_UMD|evm.model.AC_000160.1.1254 Q99627 CSN8_HUMAN 96.651 0.990476 1.00478 COPS8 - COP9 signalosome complex subunit 8 - Homo sapiens (Human) - COPS8 gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Taurus_UMD|evm.model.AC_000160.1.1255 P15989 CO6A3_CHICK 65.682 0.866626 1.05164 COL6A3 - Collagen alpha-3(VI) chain precursor - Gallus gallus (Chicken) - COL6A3 gene Collagen VI acts as a cell-binding protein. Taurus_UMD|evm.model.AC_000160.1.1256 P62250 RS16_RAT 97.945 0.986301 1 Rps16 - 40S ribosomal protein S16 - Rattus norvegicus (Rat) - Rps16 gene cytosolic small ribosomal subunit, small ribosomal subunit, RNA binding, structural constituent of ribosome, cellular response to leukemia inhibitory factor, liver regeneration, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit biogenesis, rRNA processing, translation Taurus_UMD|evm.model.AC_000160.1.1258 P81264 PRRP_BOVIN 98.980 0.137784 7.18367 PRLH - Prolactin-releasing peptide precursor - Bos taurus (Bovine) - PRLH gene Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL. Taurus_UMD|evm.model.AC_000160.1.1259 Q9H0T7 RAB17_HUMAN 61.086 0.724252 1.41981 RAB17 - Ras-related protein Rab-17 - Homo sapiens (Human) - RAB17 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration. Taurus_UMD|evm.model.AC_000160.1.1260 Q3UZ39 LRRF1_MOUSE 83.333 0.433551 0.62963 Lrrfip1 - Leucine-rich repeat flightless-interacting protein 1 - Mus musculus (Mouse) - Lrrfip1 gene Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA (By similarity). Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity). Taurus_UMD|evm.model.AC_000160.1.1261 E1BC15 RBM44_BOVIN 99.145 0.998097 1 RBM44 - RNA-binding protein 44 - Bos taurus (Bovine) - RBM44 gene Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility (By similarity). Taurus_UMD|evm.model.AC_000160.1.1262 Q867C0 RAMP1_PIG 79.054 0.986577 1.00676 RAMP1 - Receptor activity-modifying protein 1 precursor - Sus scrofa (Pig) - RAMP1 gene Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL (By similarity). Taurus_UMD|evm.model.AC_000160.1.1264 Q1RMW1 UBE2F_BOVIN 100.000 0.989247 1.00541 UBE2F - NEDD8-conjugating enzyme UBE2F - Bos taurus (Bovine) - UBE2F gene Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. Taurus_UMD|evm.model.AC_000160.1.1265 A2VDS1 SCLY_BOVIN 100.000 0.995434 1.00229 SCLY - Selenocysteine lyase - Bos taurus (Bovine) - SCLY gene Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. Taurus_UMD|evm.model.AC_000160.1.1266 Q9ET47 ESPN_MOUSE 78.571 0.0263415 1.17681 Espn - Espin - Mus musculus (Mouse) - Espn gene Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells (PubMed:14657236, PubMed:15190118). Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia (PubMed:21455486). Involved in the elongation of actin in stereocilia (PubMed:19287378, PubMed:22264607). In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation (PubMed:26926603). Taurus_UMD|evm.model.AC_000160.1.1267 Q0D2K2 KLH30_HUMAN 87.540 0.971963 0.555363 KLHL30 - Kelch-like protein 30 - Homo sapiens (Human) - KLHL30 gene Taurus_UMD|evm.model.AC_000160.1.1268 Q0D2K2 KLH30_HUMAN 88.372 0.986175 0.375433 KLHL30 - Kelch-like protein 30 - Homo sapiens (Human) - KLHL30 gene Taurus_UMD|evm.model.AC_000160.1.1269 Q4G0M1 ERFE_HUMAN 84.483 0.112871 1.42655 ERFE - Erythroferrone precursor - Homo sapiens (Human) - ERFE gene Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. Taurus_UMD|evm.model.AC_000160.1.1270 Q0IIF0 ILKAP_BOVIN 94.388 0.994911 1.06216 ILKAP - Integrin-linked kinase-associated serine/threonine phosphatase 2C - Bos taurus (Bovine) - ILKAP gene Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity). Taurus_UMD|evm.model.AC_000160.1.1271 Q96HZ4 HES6_HUMAN 87.111 0.99115 1.00893 HES6 - Transcription cofactor HES-6 - Homo sapiens (Human) - HES6 gene Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity). Taurus_UMD|evm.model.AC_000160.1.1272 O15055 PER2_HUMAN 64.626 0.966622 0.596813 PER2 - Period circadian protein homolog 2 - Homo sapiens (Human) - PER2 gene Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-ARTNL/BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-ARTNL/BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like ARNTL or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. Taurus_UMD|evm.model.AC_000160.1.1273 O15055 PER2_HUMAN 83.240 0.411674 1.03745 PER2 - Period circadian protein homolog 2 - Homo sapiens (Human) - PER2 gene Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-ARTNL/BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-ARTNL/BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like ARNTL or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. Taurus_UMD|evm.model.AC_000160.1.1274 Q8TDR0 MIPT3_HUMAN 73.714 0.997041 0.978292 TRAF3IP1 - TRAF3-interacting protein 1 - Homo sapiens (Human) - TRAF3IP1 gene Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity). Taurus_UMD|evm.model.AC_000160.1.1275 Q9Y576 ASB1_HUMAN 95.224 0.993994 0.99403 ASB1 - Ankyrin repeat and SOCS box protein 1 - Homo sapiens (Human) - ASB1 gene May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000160.1.1277 P97831 TWST2_RAT 100.000 0.987578 1.00625 Twist2 - Twist-related protein 2 - Rattus norvegicus (Rat) - Twist2 gene Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors (By similarity). Taurus_UMD|evm.model.AC_000160.1.1279 Q9UPS8 ANR26_HUMAN 67.320 0.706977 0.125731 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000160.1.1280 Q9D6Y1 CCDC3_MOUSE 82.759 0.834951 0.377289 Ccdc3 - Coiled-coil domain-containing protein 3 precursor - Mus musculus (Mouse) - Ccdc3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (By similarity). Positively regulates lipid accumulation in adipose cells (PubMed:25605713). Taurus_UMD|evm.model.AC_000160.1.1282 P56524 HDAC4_HUMAN 92.108 0.987156 1.00554 HDAC4 - Histone deacetylase 4 - Homo sapiens (Human) - HDAC4 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). Taurus_UMD|evm.model.AC_000160.1.1283 P15509 CSF2R_HUMAN 56.587 0.384259 2.16 CSF2RA - Granulocyte-macrophage colony-stimulating factor receptor subunit alpha precursor - Homo sapiens (Human) - CSF2RA gene Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Taurus_UMD|evm.model.AC_000160.1.1287 P34942 NDUAA_BOVIN 100.000 0.77027 0.215743 NDUFA10 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor - Bos taurus (Bovine) - NDUFA10 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000160.1.1288 Q60894 OLF12_MOUSE 69.595 0.996269 0.804805 Olfr12 - Olfactory receptor 12 - Mus musculus (Mouse) - Olfr12 gene Odorant receptor. Taurus_UMD|evm.model.AC_000160.1.1289 P34942 NDUAA_BOVIN 97.727 0.992453 0.772595 NDUFA10 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor - Bos taurus (Bovine) - NDUFA10 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000160.1.1290 Q3MHR0 LYPA1_BOVIN 93.567 0.982659 0.752174 LYPLA1 - Acyl-protein thioesterase 1 - Bos taurus (Bovine) - LYPLA1 gene Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (By similarity). Has depalmitoylating activity toward KCNMA1 (By similarity). Could also depalmitoylate ADRB2 (By similarity). Acts as a lysophospholipase hydrolyzing various lysophospholipids including lysophosphatidylcholine (lyso-PC), lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity (By similarity). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (By similarity). Taurus_UMD|evm.model.AC_000160.1.1291 Q6DDA3 CSN9_XENTR 100.000 0.275 2.80702 cops9 - COP9 signalosome complex subunit 9 - Xenopus tropicalis (Western clawed frog) - cops9 gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity. May play a role in cell proliferation. Taurus_UMD|evm.model.AC_000160.1.1292 Q8NHW6 OTOSP_HUMAN 92.754 0.272 2.80899 OTOS - Otospiralin precursor - Homo sapiens (Human) - OTOS gene May be essential for the survival of the neurosensory epithelium of the inner ear. Taurus_UMD|evm.model.AC_000160.1.1293 P20821 GCSH_BOVIN 78.378 0.444444 0.468208 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Taurus_UMD|evm.model.AC_000160.1.1295 G5E872 RNPL1_MOUSE 91.241 0.125483 1.43889 Rnpepl1 - Aminopeptidase RNPEPL1 - Mus musculus (Mouse) - Rnpepl1 gene Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine. Taurus_UMD|evm.model.AC_000160.1.1296 G5E872 RNPL1_MOUSE 94.724 0.994845 0.538889 Rnpepl1 - Aminopeptidase RNPEPL1 - Mus musculus (Mouse) - Rnpepl1 gene Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine. Taurus_UMD|evm.model.AC_000160.1.1297 Q95LP4 CAN10_MACFA 81.911 0.904031 0.797856 CAPN10 - Calpain-10 - Macaca fascicularis (Crab-eating macaque) - CAPN10 gene Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake (By similarity). Taurus_UMD|evm.model.AC_000160.1.1298 G3X745 GPC1_BOVIN 100.000 0.996429 1.00179 GPC1 - Glypican-1 precursor - Bos taurus (Bovine) - GPC1 gene Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN (C) to PRNP (Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling (By similarity). Taurus_UMD|evm.model.AC_000160.1.1299 Q8CHJ2 AQP12_MOUSE 68.837 0.866397 0.851724 Aqp12 - Aquaporin-12 - Mus musculus (Mouse) - Aqp12 gene Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. Taurus_UMD|evm.model.AC_000160.1.1301 Q12756 KIF1A_HUMAN 98.032 0.48427 1.05325 KIF1A - Kinesin-like protein KIF1A - Homo sapiens (Human) - KIF1A gene Motor for anterograde axonal transport of synaptic vesicle precursors. Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. Taurus_UMD|evm.model.AC_000160.1.1302 P21549 SPYA_HUMAN 80.867 0.942169 1.05867 AGXT - Serine--pyruvate aminotransferase - Homo sapiens (Human) - AGXT gene cytosol, intracellular membrane-bounded organelle, peroxisomal matrix, peroxisome, alanine-glyoxylate transaminase activity, amino acid binding, identical protein binding, protein homodimerization activity, protein self-association, pyridoxal phosphate binding Taurus_UMD|evm.model.AC_000160.1.1303 Q08AI8 MB214_HUMAN 77.523 0.993151 0.979866 MAB21L4 - Protein mab-21-like 4 - Homo sapiens (Human) - MAB21L4 gene Taurus_UMD|evm.model.AC_000160.1.1304 H7BZ55 CRCC2_HUMAN 61.072 0.997828 0.835451 CROCC2 - Ciliary rootlet coiled-coil protein 2 - Homo sapiens (Human) - CROCC2 gene Taurus_UMD|evm.model.AC_000160.1.1305 Q8TER0 SNED1_HUMAN 87.732 0.986922 0.811748 SNED1 - Sushi, nidogen and EGF-like domain-containing protein 1 precursor - Homo sapiens (Human) - SNED1 gene Notch binding Taurus_UMD|evm.model.AC_000160.1.1306 Q8TER0 SNED1_HUMAN 67.290 0.477477 0.157113 SNED1 - Sushi, nidogen and EGF-like domain-containing protein 1 precursor - Homo sapiens (Human) - SNED1 gene Notch binding Taurus_UMD|evm.model.AC_000160.1.1307 Q7Z6M4 MTEF4_HUMAN 73.433 0.956395 0.902887 MTERF4 - Transcription termination factor 4, mitochondrial precursor - Homo sapiens (Human) - MTERF4 gene Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S). Taurus_UMD|evm.model.AC_000160.1.1308 Q96RG2 PASK_HUMAN 67.578 0.968892 0.996221 PASK - PAS domain-containing serine/threonine-protein kinase - Homo sapiens (Human) - PASK gene Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. Taurus_UMD|evm.model.AC_000160.1.1309 Q3T0W4 PP1R7_BOVIN 100.000 0.99446 1.00278 PPP1R7 - Protein phosphatase 1 regulatory subunit 7 - Bos taurus (Bovine) - PPP1R7 gene Regulatory subunit of protein phosphatase 1. Inactivates the PPP1CC isoform 2 during epididymal sperm maturation. Taurus_UMD|evm.model.AC_000160.1.1311 Q8VDJ3 VIGLN_MOUSE 74.394 0.89837 0.822555 Hdlbp - Vigilin - Mus musculus (Mouse) - Hdlbp gene Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol (By similarity). Taurus_UMD|evm.model.AC_000160.1.1312 Q2NKY7 SEPT2_BOVIN 94.737 0.655769 1.44044 SEPTIN2 - Septin-2 - Bos taurus (Bovine) - SEPTIN2 gene Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein (By similarity). Taurus_UMD|evm.model.AC_000160.1.1313 O94887 FARP2_HUMAN 63.492 0.62 0.0948767 FARP2 - FERM, ARHGEF and pleckstrin domain-containing protein 2 - Homo sapiens (Human) - FARP2 gene Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). Taurus_UMD|evm.model.AC_000160.1.1314 O94887 FARP2_HUMAN 73.684 0.389474 0.0901328 FARP2 - FERM, ARHGEF and pleckstrin domain-containing protein 2 - Homo sapiens (Human) - FARP2 gene Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). Taurus_UMD|evm.model.AC_000160.1.1315 Q91VS8 FARP2_MOUSE 86.538 0.326923 0.146479 Farp2 - FERM, ARHGEF and pleckstrin domain-containing protein 2 - Mus musculus (Mouse) - Farp2 gene Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity (PubMed:23375260 and PubMed:20702777). Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion. Taurus_UMD|evm.model.AC_000160.1.1316 O94887 FARP2_HUMAN 87.705 0.237721 0.482922 FARP2 - FERM, ARHGEF and pleckstrin domain-containing protein 2 - Homo sapiens (Human) - FARP2 gene Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). Taurus_UMD|evm.model.AC_000160.1.1317 Q3SWY6 STK25_BOVIN 99.765 0.995316 1.00235 STK25 - Serine/threonine-protein kinase 25 - Bos taurus (Bovine) - STK25 gene Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration (By similarity). Taurus_UMD|evm.model.AC_000160.1.1318 Q9UMX3 BOK_HUMAN 94.366 0.990654 1.00943 BOK - Bcl-2-related ovarian killer protein - Homo sapiens (Human) - BOK gene Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155). Taurus_UMD|evm.model.AC_000160.1.1319 Q2TBI2 THAP4_BOVIN 99.642 0.93 1.0274 THAP4 - Peroxynitrite isomerase THAP4 - Bos taurus (Bovine) - THAP4 gene In vitro catalyzes the heme-based conversion of peroxynitrite into nitrate/NO3-. May be involved in the detoxification of peroxynitrite which is responsible for the nitration of L-free tyrosine. Also selectively binds nitric oxide/NO in vitro. Taurus_UMD|evm.model.AC_000160.1.1320 Q6PZ03 ATG4B_BOVIN 100.000 0.902552 1.09669 ATG4B - Cysteine protease ATG4B - Bos taurus (Bovine) - ATG4B gene Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity). Taurus_UMD|evm.model.AC_000160.1.1321 P23919 KTHY_HUMAN 83.412 0.985915 1.00472 DTYMK - Thymidylate kinase - Homo sapiens (Human) - DTYMK gene Catalyzes the conversion of dTMP to dTDP. Taurus_UMD|evm.model.AC_000160.1.1322 Q8WYH8 ING5_HUMAN 93.220 0.608808 1.60833 ING5 - Inhibitor of growth protein 5 - Homo sapiens (Human) - ING5 gene Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715). Taurus_UMD|evm.model.AC_000160.1.1323 Q1JPD3 D2HDH_BOVIN 100.000 0.99633 1.00184 D2HGDH - D-2-hydroxyglutarate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - D2HGDH gene Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate. Taurus_UMD|evm.model.AC_000160.1.1324 Q6XQG9 G3ST2_PIG 79.028 0.921986 1.06281 GAL3ST2 - Galactose-3-O-sulfotransferase 2 - Sus scrofa (Pig) - GAL3ST2 gene Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency (By similarity). Taurus_UMD|evm.model.AC_000160.1.1325 Q8WWR8 NEUR4_HUMAN 73.770 0.995825 0.989669 NEU4 - Sialidase-4 - Homo sapiens (Human) - NEU4 gene Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:15847605, PubMed:21521691, PubMed:15213228). Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (PubMed:21521691). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:15847605). Taurus_UMD|evm.model.AC_000160.1.1326 Q15116 PDCD1_HUMAN 63.793 0.992933 0.982639 PDCD1 - Programmed cell death protein 1 precursor - Homo sapiens (Human) - PDCD1 gene Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity). Taurus_UMD|evm.model.AC_000160.1.1328 Q14D33 RTP5_HUMAN 36.903 0.989031 0.956294 RTP5 - Receptor-transporting protein 5 - Homo sapiens (Human) - RTP5 gene olfactory receptor binding, detection of chemical stimulus involved in sensory perception of bitter taste, protein insertion into membrane, protein targeting to membrane Taurus_UMD|evm.model.AC_000160.1.1329 A0A1B0GVR7 F240C_HUMAN 55.914 0.356589 2.71579 FAM240C - Protein FAM240C - Homo sapiens (Human) - FAM240C gene Taurus_UMD|evm.model.AC_000160.1.1330 Q9Y2W2 WBP11_HUMAN 90.756 0.861314 0.213729 WBP11 - WW domain-binding protein 11 - Homo sapiens (Human) - WBP11 gene Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. Taurus_UMD|evm.model.AC_000160.1.1331 Q9Y2W2 WBP11_HUMAN 79.798 0.592593 0.25273 WBP11 - WW domain-binding protein 11 - Homo sapiens (Human) - WBP11 gene Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. Taurus_UMD|evm.model.AC_000160.1.1332 D6RBQ6 U17LH_HUMAN 51.895 0.809756 0.773585 USP17L17 - Ubiquitin carboxyl-terminal hydrolase 17-like protein 17 - Homo sapiens (Human) - USP17L17 gene Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. Taurus_UMD|evm.model.AC_000161.1.3 Q8TAG5 VTM2A_HUMAN 91.667 0.895833 1.01695 VSTM2A - V-set and transmembrane domain-containing protein 2A precursor - Homo sapiens (Human) - VSTM2A gene Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway. Taurus_UMD|evm.model.AC_000161.1.4 P11260 LORF1_MOUSE 38.095 0.744361 0.372549 Lire1 - LINE-1 retrotransposable element ORF1 protein - Mus musculus (Mouse) - Lire1 gene Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. Taurus_UMD|evm.model.AC_000161.1.5 Q10126 YSM6_CAEEL 28.000 0.778761 0.405018 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000161.1.6 Q15125 EBP_HUMAN 51.456 0.97561 0.356522 EBP - 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase - Homo sapiens (Human) - EBP gene Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. Taurus_UMD|evm.model.AC_000161.1.8 P54252 ATX3_HUMAN 82.456 0.964286 0.155125 ATXN3 - Ataxin-3 - Homo sapiens (Human) - ATXN3 gene Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). Taurus_UMD|evm.model.AC_000161.1.11 D3ZUI5 COBL_RAT 71.925 0.282238 1.08826 Cobl - Protein cordon-bleu - Rattus norvegicus (Rat) - Cobl gene Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates dendrite branching in Purkinje cells (By similarity). Regulates neuron morphogenesis and increases branching of axons and dendrites. Taurus_UMD|evm.model.AC_000161.1.12 B5KFD7 GRB10_PIG 91.171 0.917188 1.08659 Grb10 - Growth factor receptor-bound protein 10 - Sus scrofa (Pig) - Grb10 gene Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination has also been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2 (By similarity). Taurus_UMD|evm.model.AC_000161.1.14 P27718 DDC_BOVIN 92.487 0.970976 0.778234 DDC - Aromatic-L-amino-acid decarboxylase - Bos taurus (Bovine) - DDC gene Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Taurus_UMD|evm.model.AC_000161.1.15 P27718 DDC_BOVIN 99.038 0.474654 0.445585 DDC - Aromatic-L-amino-acid decarboxylase - Bos taurus (Bovine) - DDC gene Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Taurus_UMD|evm.model.AC_000161.1.16 Q6PIW4 FIGL1_HUMAN 85.229 0.99705 1.00593 FIGNL1 - Fidgetin-like protein 1 - Homo sapiens (Human) - FIGNL1 gene Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376). May play a role in the control of male meiosis dynamic (By similarity). Taurus_UMD|evm.model.AC_000161.1.17 Q13422 IKZF1_HUMAN 90.559 0.971857 1.02697 IKZF1 - DNA-binding protein Ikaros - Homo sapiens (Human) - IKZF1 gene Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). Taurus_UMD|evm.model.AC_000161.1.20 A4D263 SPT48_HUMAN 81.463 0.639498 0.728311 SPATA48 - Spermatogenesis-associated protein 48 - Homo sapiens (Human) - SPATA48 gene Taurus_UMD|evm.model.AC_000161.1.21 Q29108 ZPBP1_PIG 80.571 0.993355 0.86 ZPBP - Zona pellucida-binding protein 1 precursor - Sus scrofa (Pig) - ZPBP gene Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization. Taurus_UMD|evm.model.AC_000161.1.22 Q2TAL6 VWC2_HUMAN 92.025 0.993884 1.00615 VWC2 - Brorin precursor - Homo sapiens (Human) - VWC2 gene BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity). Taurus_UMD|evm.model.AC_000161.1.26 P62755 RS6_RAT 87.402 0.984252 0.51004 Rps6 - 40S ribosomal protein S6 - Rattus norvegicus (Rat) - Rps6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Taurus_UMD|evm.model.AC_000161.1.27 Q86UQ4 ABCAD_HUMAN 63.930 0.995085 0.884935 ABCA13 - ATP-binding cassette sub-family A member 13 - Homo sapiens (Human) - ABCA13 gene May mediate the cholesterol and gangliosides transport from the plasma membrane to intracellular vesicles in an ATP hydrolysis dependent manner, thus playing a role in their internalization by endocytic retrograde transport and may also participate in the endocytosis of synaptic vesicle in cortical neurons. Taurus_UMD|evm.model.AC_000161.1.30 Q16831 UPP1_HUMAN 80.645 0.993548 1 UPP1 - Uridine phosphorylase 1 - Homo sapiens (Human) - UPP1 gene Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:7488099). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Taurus_UMD|evm.model.AC_000161.1.31 A0JNL1 CG057_BOVIN 99.653 0.99308 1.00347 Uncharacterized protein C7orf57 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000161.1.32 Q0II64 SUN3_BOVIN 95.109 0.99458 1.025 SUN3 - SUN domain-containing protein 3 - Bos taurus (Bovine) - SUN3 gene As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. Taurus_UMD|evm.model.AC_000161.1.33 Q0IIL2 CLD12_BOVIN 100.000 0.991837 1.0041 CLDN12 - Claudin-12 - Bos taurus (Bovine) - CLDN12 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Taurus_UMD|evm.model.AC_000161.1.34 P0DTF9 PTIP2_HUMAN 52.564 0.986928 0.993506 PTTG1IP2 - PTTG1IP family member 2 precursor - Homo sapiens (Human) - PTTG1IP2 gene Taurus_UMD|evm.model.AC_000161.1.36 B0VXE8 CDK14_CALJA 99.180 0.858156 0.333333 CDK14 - Cyclin-dependent kinase 14 - Callithrix jacchus (White-tufted-ear marmoset) - CDK14 gene Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity). Taurus_UMD|evm.model.AC_000161.1.37 Q9UP38 FZD1_HUMAN 96.621 0.996904 0.998454 FZD1 - Frizzled-1 precursor - Homo sapiens (Human) - FZD1 gene Receptor for Wnt proteins (PubMed:10557084). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084). Contradictory results showing activation by WNT7B have been described for mouse (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Taurus_UMD|evm.model.AC_000161.1.38 Q9NVP1 DDX18_HUMAN 85.607 0.87385 1.13582 DDX18 - ATP-dependent RNA helicase DDX18 - Homo sapiens (Human) - DDX18 gene Probable RNA-dependent helicase. Taurus_UMD|evm.model.AC_000161.1.40 Q62725 NFYC_RAT 76.389 0.835294 0.507463 Nfyc - Nuclear transcription factor Y subunit gamma - Rattus norvegicus (Rat) - Nfyc gene Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. Taurus_UMD|evm.model.AC_000161.1.41 Q99551 MTEF1_HUMAN 79.592 0.93765 1.04511 MTERF1 - Transcription termination factor 1, mitochondrial precursor - Homo sapiens (Human) - MTERF1 gene Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand. Taurus_UMD|evm.model.AC_000161.1.42 Q99996 AKAP9_HUMAN 84.894 0.961129 1.03379 AKAP9 - A-kinase anchor protein 9 - Homo sapiens (Human) - AKAP9 gene Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). Taurus_UMD|evm.model.AC_000161.1.43 Q4PJW3 CP51A_BOVIN 100.000 0.996024 1.00199 CYP51A1 - Lanosterol 14-alpha demethylase - Bos taurus (Bovine) - CYP51A1 gene A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25-dihydrolanosterol likely through sequential oxidative conversion of 14-alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Taurus_UMD|evm.model.AC_000161.1.44 A4D1F6 LRRD1_HUMAN 77.535 0.997685 1.00465 LRRD1 - Leucine-rich repeat and death domain-containing protein 1 - Homo sapiens (Human) - LRRD1 gene positive regulation of Ras protein signal transduction, signal transduction Taurus_UMD|evm.model.AC_000161.1.45 Q6TNJ1 KRIT1_BOVIN 99.457 0.997286 1.00136 KRIT1 - Krev interaction trapped protein 1 - Bos taurus (Bovine) - KRIT1 gene Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000161.1.46 Q9P2G1 AKIB1_HUMAN 97.368 0.904535 0.384757 ANKIB1 - Ankyrin repeat and IBR domain-containing protein 1 - Homo sapiens (Human) - ANKIB1 gene Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. Taurus_UMD|evm.model.AC_000161.1.47 Q9P2G1 AKIB1_HUMAN 94.220 0.99711 0.635445 ANKIB1 - Ankyrin repeat and IBR domain-containing protein 1 - Homo sapiens (Human) - ANKIB1 gene Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. Taurus_UMD|evm.model.AC_000161.1.48 Q8K097 LFG2_MOUSE 44.843 0.721854 0.952681 Faim2 - Protein lifeguard 2 - Mus musculus (Mouse) - Faim2 gene Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. Taurus_UMD|evm.model.AC_000161.1.49 A2VDY6 GATA1_BOVIN 100.000 0.992674 1.00368 GATAD1 - GATA zinc finger domain-containing protein 1 - Bos taurus (Bovine) - GATAD1 gene nucleus, chromatin organization Taurus_UMD|evm.model.AC_000161.1.50 O43933 PEX1_HUMAN 87.217 0.99844 0.999221 PEX1 - Peroxisome biogenesis factor 1 - Homo sapiens (Human) - PEX1 gene Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Taurus_UMD|evm.model.AC_000161.1.51 A6QPE1 RBM48_BOVIN 100.000 0.99449 1.00276 RBM48 - RNA-binding protein 48 - Bos taurus (Bovine) - RBM48 gene nucleoplasm Taurus_UMD|evm.model.AC_000161.1.52 Q3KQ77 EFCB1_XENLA 59.896 0.892523 1.02885 efcab1 - EF-hand calcium-binding domain-containing protein 1 - Xenopus laevis (African clawed frog) - efcab1 gene Taurus_UMD|evm.model.AC_000161.1.53 Q5BKY9 F133B_HUMAN 95.951 0.991935 1.00405 FAM133B - Protein FAM133B - Homo sapiens (Human) - FAM133B gene RNA binding Taurus_UMD|evm.model.AC_000161.1.54 Q00534 CDK6_HUMAN 97.177 0.991968 0.763804 CDK6 - Cyclin-dependent kinase 6 - Homo sapiens (Human) - CDK6 gene Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). Taurus_UMD|evm.model.AC_000161.1.55 Q5K651 SAMD9_HUMAN 80.176 0.998736 0.995595 SAMD9 - Sterile alpha motif domain-containing protein 9 - Homo sapiens (Human) - SAMD9 gene May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion. Taurus_UMD|evm.model.AC_000161.1.56 A6QQC6 HECA2_BOVIN 99.172 0.954455 1.02851 HEPACAM2 - HEPACAM family member 2 precursor - Bos taurus (Bovine) - HEPACAM2 gene Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation (By similarity). Taurus_UMD|evm.model.AC_000161.1.57 Q96JG6 VPS50_HUMAN 94.398 0.997854 0.966805 VPS50 - Syndetin - Homo sapiens (Human) - VPS50 gene Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). Taurus_UMD|evm.model.AC_000161.1.58 P25117 CALCR_PIG 81.224 0.840741 1.08434 CALCR - Calcitonin receptor precursor - Sus scrofa (Pig) - CALCR gene This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. The receptor can also couple to an additional signaling pathway via a pertussis toxin-sensitive g protein in isolated osteoclasts and in LLC-PK1 cells. Taurus_UMD|evm.model.AC_000161.1.59 Q7YRQ8 TFPI2_BOVIN 100.000 0.991489 1.00427 TFPI2 - Tissue factor pathway inhibitor 2 precursor - Bos taurus (Bovine) - TFPI2 gene May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. Taurus_UMD|evm.model.AC_000161.1.60 P02698 GBG1_BOVIN 100.000 0.973333 1.01351 GNGT1 - Guanine nucleotide-binding protein G(T) subunit gamma-T1 precursor - Bos taurus (Bovine) - GNGT1 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Taurus_UMD|evm.model.AC_000161.1.61 O15155 BET1_HUMAN 95.763 0.983193 1.00847 BET1 - BET1 homolog - Homo sapiens (Human) - BET1 gene Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity). Taurus_UMD|evm.model.AC_000161.1.62 P02465 CO1A2_BOVIN 97.361 0.998495 0.97434 COL1A2 - Collagen alpha-2(I) chain precursor - Bos taurus (Bovine) - COL1A2 gene Type I collagen is a member of group I collagen (fibrillar forming collagen). Taurus_UMD|evm.model.AC_000161.1.63 Q96PB1 CASD1_HUMAN 97.240 0.845909 1.18068 CASD1 - N-acetylneuraminate 9-O-acetyltransferase - Homo sapiens (Human) - CASD1 gene O-acetyltransferase that catalyzes 9-O-acetylation of sialic acids (PubMed:20947662, PubMed:26169044). Sialic acids are sugars at the reducing end of glycoproteins and glycolipids, and are involved in various processes such as cell-cell interactions, host-pathogen recognition (PubMed:20947662, PubMed:26169044). Taurus_UMD|evm.model.AC_000161.1.64 Q29S03 SGCE_BOVIN 99.771 0.995434 1.00229 SGCE - Epsilon-sarcoglycan - Bos taurus (Bovine) - SGCE gene Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Taurus_UMD|evm.model.AC_000161.1.65 Q86TG7 PEG10_HUMAN 90.491 0.800493 0.573446 PEG10 - Retrotransposon-derived protein PEG10 - Homo sapiens (Human) - PEG10 gene Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis (PubMed:12810624). May also have a role in cell growth promotion and hepatoma formation (PubMed:12810624, PubMed:16423995). Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ACVRL1 (PubMed:15611116). When overexpressed, induces the formation of cellular extension, such as filipodia in association with ACVRL1 (PubMed:15611116). Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity). Taurus_UMD|evm.model.AC_000161.1.66 Q86TG7 PEG10_HUMAN 92.401 0.913165 0.504237 PEG10 - Retrotransposon-derived protein PEG10 - Homo sapiens (Human) - PEG10 gene Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis (PubMed:12810624). May also have a role in cell growth promotion and hepatoma formation (PubMed:12810624, PubMed:16423995). Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ACVRL1 (PubMed:15611116). When overexpressed, induces the formation of cellular extension, such as filipodia in association with ACVRL1 (PubMed:15611116). Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity). Taurus_UMD|evm.model.AC_000161.1.67 Q9ULJ8 NEB1_HUMAN 89.444 0.129474 1.19581 PPP1R9A - Neurabin-1 - Homo sapiens (Human) - PPP1R9A gene Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity (By similarity). Taurus_UMD|evm.model.AC_000161.1.68 P27169 PON1_HUMAN 82.254 0.994382 1.00282 PON1 - Serum paraoxonase/arylesterase 1 - Homo sapiens (Human) - PON1 gene Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. Taurus_UMD|evm.model.AC_000161.1.69 Q15166 PON3_HUMAN 81.356 0.994366 1.00282 PON3 - Serum paraoxonase/lactonase 3 - Homo sapiens (Human) - PON3 gene Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. Taurus_UMD|evm.model.AC_000161.1.70 Q58DS7 PON2_BOVIN 100.000 0.994366 1.00282 PON2 - Serum paraoxonase/arylesterase 2 - Bos taurus (Bovine) - PON2 gene Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Taurus_UMD|evm.model.AC_000161.1.71 Q9Y574 ASB4_HUMAN 95.604 0.997253 0.85446 ASB4 - Ankyrin repeat and SOCS box protein 4 - Homo sapiens (Human) - ASB4 gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity). Taurus_UMD|evm.model.AC_000161.1.72 Q5R893 H2B1_PONAB 94.444 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000161.1.73 Q16654 PDK4_HUMAN 91.912 0.985294 0.992701 PDK4 - [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial precursor - Homo sapiens (Human) - PDK4 gene Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism. Taurus_UMD|evm.model.AC_000161.1.75 O88485 DC1I1_MOUSE 97.771 0.961656 1.03822 Dync1i1 - Cytoplasmic dynein 1 intermediate chain 1 - Mus musculus (Mouse) - Dync1i1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. Taurus_UMD|evm.model.AC_000161.1.76 Q9UJS0 CMC2_HUMAN 97.313 0.997019 0.994074 SLC25A13 - Calcium-binding mitochondrial carrier protein Aralar2 - Homo sapiens (Human) - SLC25A13 gene Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane (PubMed:11566871, PubMed:25410934). May have a function in the urea cycle (PubMed:11566871). Taurus_UMD|evm.model.AC_000161.1.77 Q4R7Y2 RL10_MACFA 78.378 0.973333 0.350467 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000161.1.78 P83883 RL36A_RAT 95.283 0.981308 1.00943 Rpl36a - 60S ribosomal protein L36a - Rattus norvegicus (Rat) - Rpl36a gene cytosolic large ribosomal subunit, nucleus, response to organic substance, response to retinoic acid Taurus_UMD|evm.model.AC_000161.1.79 P60897 SEM1_MOUSE 100.000 0.341085 1.84286 Sem1 - 26S proteasome complex subunit SEM1 - Mus musculus (Mouse) - Sem1 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells. Taurus_UMD|evm.model.AC_000161.1.80 P26583 HMGB2_HUMAN 100.000 0.987421 0.760766 HMGB2 - High mobility group protein B2 - Homo sapiens (Human) - HMGB2 gene Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity). Taurus_UMD|evm.model.AC_000161.1.82 P70397 DLX6_MOUSE 99.429 0.728033 1.36571 Dlx6 - Homeobox protein DLX-6 - Mus musculus (Mouse) - Dlx6 gene DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, anatomical structure formation involved in morphogenesis, cell differentiation, embryonic limb morphogenesis, epithelial cell differentiation, head development, inner ear morphogenesis, positive regulation of epithelial cell proliferation Taurus_UMD|evm.model.AC_000161.1.83 P56178 DLX5_HUMAN 97.578 0.993103 1.00346 DLX5 - Homeobox protein DLX-5 - Homo sapiens (Human) - DLX5 gene Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. Taurus_UMD|evm.model.AC_000161.1.84 A6QNT8 SC24A_BOVIN 99.096 0.973529 0.309372 SEC24A - Protein transport protein Sec24A - Bos taurus (Bovine) - SEC24A gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes. Taurus_UMD|evm.model.AC_000161.1.85 Q0P574 SDHF3_BOVIN 100.000 0.734177 0.632 SDHAF3 - Succinate dehydrogenase assembly factor 3, mitochondrial precursor - Bos taurus (Bovine) - SDHAF3 gene Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. Taurus_UMD|evm.model.AC_000161.1.86 Q0P574 SDHF3_BOVIN 100.000 0.970588 0.544 SDHAF3 - Succinate dehydrogenase assembly factor 3, mitochondrial precursor - Bos taurus (Bovine) - SDHAF3 gene Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. Taurus_UMD|evm.model.AC_000161.1.88 P01289 TKN1_BOVIN 100.000 0.984733 1.00769 TAC1 - Protachykinin-1 precursor - Bos taurus (Bovine) - TAC1 gene Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Taurus_UMD|evm.model.AC_000161.1.89 Q1LZA3 ASNS_BOVIN 100.000 0.996441 1.00178 ASNS - Asparagine synthetase [glutamine-hydrolyzing] - Bos taurus (Bovine) - ASNS gene cytosol, asparagine synthase (glutamine-hydrolyzing) activity, asparagine biosynthetic process Taurus_UMD|evm.model.AC_000161.1.91 Q0VC84 C1GLT_BOVIN 100.000 0.735608 1.27446 C1GALT1 - Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 - Bos taurus (Bovine) - C1GALT1 gene Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity). Taurus_UMD|evm.model.AC_000161.1.92 Q2UY09 COSA1_HUMAN 73.171 0.998113 0.942222 COL28A1 - Collagen alpha-1(XXVIII) chain precursor - Homo sapiens (Human) - COL28A1 gene May act as a cell-binding protein. Taurus_UMD|evm.model.AC_000161.1.93 Q5RCA2 MIO_PONAB 97.229 0.977376 0.505143 MIOS - GATOR complex protein MIOS - Pongo abelii (Sumatran orangutan) - MIOS gene As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. Taurus_UMD|evm.model.AC_000161.1.94 Q9NXC5 MIO_HUMAN 98.624 0.995423 0.499429 MIOS - GATOR complex protein MIOS - Homo sapiens (Human) - MIOS gene As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). Taurus_UMD|evm.model.AC_000161.1.95 P35244 RFA3_HUMAN 86.667 0.97541 1.00826 RPA3 - Replication protein A 14 kDa subunit - Homo sapiens (Human) - RPA3 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER), probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA (PubMed:19010961). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). Taurus_UMD|evm.model.AC_000161.1.97 C9J7I0 UMAD1_HUMAN 85.526 0.342466 1.59854 UMAD1 - UBAP1-MVB12-associated (UMA)-domain containing protein 1 - Homo sapiens (Human) - UMAD1 gene Taurus_UMD|evm.model.AC_000161.1.98 Q86VQ1 GLCI1_HUMAN 96.709 0.96798 0.74223 GLCCI1 - Glucocorticoid-induced transcript 1 protein - Homo sapiens (Human) - GLCCI1 gene cytoplasm Taurus_UMD|evm.model.AC_000161.1.99 Q05084 ICA69_HUMAN 91.718 0.995842 0.995859 ICA1 - Islet cell autoantigen 1 - Homo sapiens (Human) - ICA1 gene May play a role in neurotransmitter secretion. Taurus_UMD|evm.model.AC_000161.1.100 P29693 EF1D_XENLA 76.543 0.462428 0.65283 eef1d - Elongation factor 1-delta - Xenopus laevis (African clawed frog) - eef1d gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Taurus_UMD|evm.model.AC_000161.1.101 Q5E9M6 NXPH1_BOVIN 100.000 0.992647 1.00369 NXPH1 - Neurexophilin-1 precursor - Bos taurus (Bovine) - NXPH1 gene May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity). Taurus_UMD|evm.model.AC_000161.1.102 Q6WV74 H4_MYTCH 96.429 0.922222 0.873786 Histone H4 - Mytilus chilensis (Chilean blue mussel) Taurus_UMD|evm.model.AC_000161.1.104 Q8N0T1 RBIS_HUMAN 83.000 0.980198 1.01 RBIS - Ribosomal biogenesis factor - Homo sapiens (Human) - RBIS gene Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production. Taurus_UMD|evm.model.AC_000161.1.105 Q01321 NDUA4_BOVIN 100.000 0.975904 1.0122 NDUFA4 - Cytochrome c oxidase subunit NDUFA4 - Bos taurus (Bovine) - NDUFA4 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (By similarity). NDUFA4 is required for complex IV maintenance (By similarity). Taurus_UMD|evm.model.AC_000161.1.106 O94880 PHF14_HUMAN 97.288 0.906282 1.09347 PHF14 - PHD finger protein 14 - Homo sapiens (Human) - PHF14 gene MOZ/MORF histone acetyltransferase complex, histone binding, histone H3-K14 acetylation, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000161.1.107 Q9UPZ6 THS7A_HUMAN 92.569 0.998739 0.957151 THSD7A - Thrombospondin type-1 domain-containing protein 7A precursor - Homo sapiens (Human) - THSD7A gene Plays a role in actin cytoskeleton rearrangement. Taurus_UMD|evm.model.AC_000161.1.108 Q3ZC25 T106B_BOVIN 100.000 0.858934 1.16 TMEM106B - Transmembrane protein 106B - Bos taurus (Bovine) - TMEM106B gene Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching (By similarity). Taurus_UMD|evm.model.AC_000161.1.109 O94887 FARP2_HUMAN 63.492 0.62 0.0948767 FARP2 - FERM, ARHGEF and pleckstrin domain-containing protein 2 - Homo sapiens (Human) - FARP2 gene Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). Taurus_UMD|evm.model.AC_000161.1.110 Q28046 ADSV_BOVIN 99.570 0.730709 0.888112 SCIN - Adseverin - Bos taurus (Bovine) - SCIN gene Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+) (PubMed:1651929, PubMed:1847925, PubMed:8780652). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (PubMed:8780652). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (By similarity). Taurus_UMD|evm.model.AC_000161.1.111 P61214 ARL4A_RAT 100.000 0.99005 1.005 Arl4a - ADP-ribosylation factor-like protein 4A - Rattus norvegicus (Rat) - Arl4a gene Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity). Taurus_UMD|evm.model.AC_000161.1.112 P79103 RS4_BOVIN 80.952 0.932039 0.78327 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000161.1.114 Q2KIC2 ETV1_BOVIN 88.477 0.995918 1.02725 ETV1 - ETS translocation variant 1 - Bos taurus (Bovine) - ETV1 gene Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. Taurus_UMD|evm.model.AC_000161.1.116 Q6ZNB7 ALKMO_HUMAN 88.090 0.995516 1.00225 AGMO - Alkylglycerol monooxygenase - Homo sapiens (Human) - AGMO gene Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes. Taurus_UMD|evm.model.AC_000161.1.117 P50222 MEOX2_HUMAN 98.684 0.993421 1 MEOX2 - Homeobox protein MOX-2 - Homo sapiens (Human) - MEOX2 gene Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000). While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity). Taurus_UMD|evm.model.AC_000161.1.118 E1BCH6 ISPD_BOVIN 100.000 0.995516 1.00225 CRPPA - D-ribitol-5-phosphate cytidylyltransferase - Bos taurus (Bovine) - CRPPA gene Cytidylyltransferase required for protein O-linked mannosylation (By similarity). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (By similarity). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively. Not Involved in dolichol production (By similarity). Taurus_UMD|evm.model.AC_000161.1.119 Q6X4U4 SOSD1_HUMAN 95.631 0.990338 1.00485 SOSTDC1 - Sclerostin domain-containing protein 1 precursor - Homo sapiens (Human) - SOSTDC1 gene May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. Taurus_UMD|evm.model.AC_000161.1.120 A6H759 LRC72_BOVIN 80.731 0.993333 1.04167 LRRC72 - Leucine-rich repeat-containing protein 72 - Bos taurus (Bovine) - LRRC72 gene Taurus_UMD|evm.model.AC_000161.1.121 Q0VCS9 ANKY2_BOVIN 100.000 0.995485 1.00226 ANKMY2 - Ankyrin repeat and MYND domain-containing protein 2 - Bos taurus (Bovine) - ANKMY2 gene May be involved in the trafficking of signaling proteins to the cilia. Taurus_UMD|evm.model.AC_000161.1.122 Q9Y6E2 BZW2_HUMAN 99.284 0.981221 1.01671 BZW2 - Basic leucine zipper and W2 domain-containing protein 2 - Homo sapiens (Human) - BZW2 gene May be involved in neuronal differentiation. Taurus_UMD|evm.model.AC_000161.1.123 Q3ZBV0 TSN13_BOVIN 100.000 0.875 1.13725 TSPAN13 - Tetraspanin-13 - Bos taurus (Bovine) - TSPAN13 gene integral component of plasma membrane Taurus_UMD|evm.model.AC_000161.1.124 O95994 AGR2_HUMAN 96.000 0.988636 1.00571 AGR2 - Anterior gradient protein 2 homolog precursor - Homo sapiens (Human) - AGR2 gene Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113). Taurus_UMD|evm.model.AC_000161.1.125 Q95LD9 AHR_DELLE 87.101 0.997633 1 AHR - Aryl hydrocarbon receptor precursor - Delphinapterus leucas (Beluga whale) - AHR gene Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer. Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation. Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists. Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands. Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription. Taurus_UMD|evm.model.AC_000161.1.127 Q9Y5W8 SNX13_HUMAN 90.405 0.807992 1.05992 SNX13 - Sorting nexin-13 - Homo sapiens (Human) - SNX13 gene May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas. Taurus_UMD|evm.model.AC_000161.1.128 P60892 PRPS1_RAT 91.167 0.957576 1.03774 Prps1 - Ribose-phosphate pyrophosphokinase 1 - Rattus norvegicus (Rat) - Prps1 gene Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Taurus_UMD|evm.model.AC_000161.1.129 Q9UKV0 HDAC9_HUMAN 82.079 0.940223 0.976261 HDAC9 - Histone deacetylase 9 - Homo sapiens (Human) - HDAC9 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Taurus_UMD|evm.model.AC_000161.1.130 Q15672 TWST1_HUMAN 99.010 0.990099 1 TWIST1 - Twist-related protein 1 - Homo sapiens (Human) - TWIST1 gene Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity). Taurus_UMD|evm.model.AC_000161.1.132 Q9VGJ5 FER3_DROME 83.077 0.387879 0.846154 fer3 - Protein Fer3 - Drosophila melanogaster (Fruit fly) - fer3 gene Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity). Taurus_UMD|evm.model.AC_000161.1.133 Q3B726 RPA43_HUMAN 77.844 0.98494 0.982249 POLR1F - DNA-directed RNA polymerase I subunit RPA43 - Homo sapiens (Human) - POLR1F gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters. Taurus_UMD|evm.model.AC_000161.1.134 Q6ZN28 MACC1_HUMAN 74.326 0.997462 0.924883 MACC1 - Metastasis-associated in colon cancer protein 1 - Homo sapiens (Human) - MACC1 gene Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. Taurus_UMD|evm.model.AC_000161.1.135 P26012 ITB8_HUMAN 91.417 0.997396 0.9987 ITGB8 - Integrin beta-8 precursor - Homo sapiens (Human) - ITGB8 gene Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072). It recognizes the sequence R-G-D in its ligands (PubMed:1918072). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity). Taurus_UMD|evm.model.AC_000161.1.136 Q2M3G0 ABCB5_HUMAN 83.564 0.950777 0.921241 ABCB5 - ATP-binding cassette sub-family B member 5 - Homo sapiens (Human) - ABCB5 gene Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:12960149, PubMed:22306008, PubMed:15899824, PubMed:15205344). Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity). Taurus_UMD|evm.model.AC_000161.1.137 Q8IXZ3 SP8_HUMAN 89.592 0.971491 0.930612 SP8 - Transcription factor Sp8 - Homo sapiens (Human) - SP8 gene Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity). Taurus_UMD|evm.model.AC_000161.1.138 P84246 H33_RABIT 94.118 0.985401 1.00735 H3-3A - Histone H3.3 - Oryctolagus cuniculus (Rabbit) - H3-3A gene Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000161.1.139 Q02446 SP4_HUMAN 92.974 0.992509 1.02168 SP4 - Transcription factor Sp4 - Homo sapiens (Human) - SP4 gene Binds to GT and GC boxes promoters elements. Probable transcriptional activator. Taurus_UMD|evm.model.AC_000161.1.140 Q96DT5 DYH11_HUMAN 82.528 0.999696 0.728742 DNAH11 - Dynein axonemal heavy chain 11 - Homo sapiens (Human) - DNAH11 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Taurus_UMD|evm.model.AC_000161.1.141 Q96GN5 CDA7L_HUMAN 87.004 0.995556 0.991189 CDCA7L - Cell division cycle-associated 7-like protein - Homo sapiens (Human) - CDCA7L gene Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. Taurus_UMD|evm.model.AC_000161.1.142 Q92565 RPGF5_HUMAN 87.382 0.825291 1.03621 RAPGEF5 - Rap guanine nucleotide exchange factor 5 - Homo sapiens (Human) - RAPGEF5 gene Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. Taurus_UMD|evm.model.AC_000161.1.146 Q8C0Q9 RPGF5_MOUSE 92.486 0.397229 0.531941 Rapgef5 - Rap guanine nucleotide exchange factor 5 - Mus musculus (Mouse) - Rapgef5 gene Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation (By similarity). Taurus_UMD|evm.model.AC_000161.1.147 Q7L190 DPPA4_HUMAN 63.415 0.547945 0.480263 DPPA4 - Developmental pluripotency-associated protein 4 - Homo sapiens (Human) - DPPA4 gene May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage. Taurus_UMD|evm.model.AC_000161.1.148 P26892 IL6_BOVIN 100.000 0.990431 1.00481 IL6 - Interleukin-6 precursor - Bos taurus (Bovine) - IL6 gene Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. Taurus_UMD|evm.model.AC_000161.1.149 A1XQS2 TOM7_PIG 76.119 0.804878 1.49091 TOMM7 - Mitochondrial import receptor subunit TOM7 homolog - Sus scrofa (Pig) - TOMM7 gene Required for assembly and stability of the TOM complex (By similarity). Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria (By similarity). Taurus_UMD|evm.model.AC_000161.1.150 P62936 PPIA_PIG 93.902 0.987879 1.0061 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Taurus_UMD|evm.model.AC_000161.1.151 Q9BYI3 HYCCI_HUMAN 87.698 0.996491 1.09405 FAM126A - Hyccin - Homo sapiens (Human) - FAM126A gene Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). May also have a role in the beta-catenin/Lef signaling pathway (Probable). Taurus_UMD|evm.model.AC_000161.1.152 Q8IXQ5 KLHL7_HUMAN 99.659 0.996593 1.00171 KLHL7 - Kelch-like protein 7 - Homo sapiens (Human) - KLHL7 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. Taurus_UMD|evm.model.AC_000161.1.153 Q5RB98 NUP42_PONAB 77.372 0.966746 0.995272 NUP42 - Nucleoporin NUP42 - Pongo abelii (Sumatran orangutan) - NUP42 gene Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. Taurus_UMD|evm.model.AC_000161.1.154 Q14956 GPNMB_HUMAN 75.352 0.989209 0.972028 GPNMB - Transmembrane glycoprotein NMB precursor - Homo sapiens (Human) - GPNMB gene Could be a melanogenic enzyme. Taurus_UMD|evm.model.AC_000161.1.155 Q96EH3 MASU1_HUMAN 77.350 0.991489 1.00427 MALSU1 - Mitochondrial assembly of ribosomal large subunit protein 1 - Homo sapiens (Human) - MALSU1 gene Required for normal mitochondrial ribosome function and mitochondrial translation (PubMed:22238375, PubMed:23171548). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable). May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome (PubMed:22238376, PubMed:23171548). May function as a ribosomal silencing factor (Probable). Taurus_UMD|evm.model.AC_000161.1.156 O00425 IF2B3_HUMAN 97.586 0.996558 1.00345 IGF2BP3 - Insulin-like growth factor 2 mRNA-binding protein 3 - Homo sapiens (Human) - IGF2BP3 gene RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Taurus_UMD|evm.model.AC_000161.1.157 Q13595 TRA2A_HUMAN 99.645 0.992908 1 TRA2A - Transformer-2 protein homolog alpha - Homo sapiens (Human) - TRA2A gene Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Taurus_UMD|evm.model.AC_000161.1.158 A2VE00 CC126_BOVIN 100.000 0.985816 1.00714 CCDC126 - Coiled-coil domain-containing protein 126 precursor - Bos taurus (Bovine) - CCDC126 gene Taurus_UMD|evm.model.AC_000161.1.159 Q9UBU7 DBF4A_HUMAN 79.204 0.997037 1.00148 DBF4 - Protein DBF4 homolog A - Homo sapiens (Human) - DBF4 gene Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. Taurus_UMD|evm.model.AC_000161.1.160 Q0VCH6 S2540_BOVIN 100.000 0.351438 0.926036 SLC25A40 - Solute carrier family 25 member 40 - Bos taurus (Bovine) - SLC25A40 gene Taurus_UMD|evm.model.AC_000161.1.161 P08183 MDR1_HUMAN 84.463 0.639963 0.848437 ABCB1 - ATP-dependent translocase ABCB1 - Homo sapiens (Human) - ABCB1 gene Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218). Taurus_UMD|evm.model.AC_000161.1.162 Q4R7B9 RUN3B_MACFA 95.814 0.940789 1 RUNDC3B - RUN domain-containing protein 3B - Macaca fascicularis (Crab-eating macaque) - RUNDC3B gene Taurus_UMD|evm.model.AC_000161.1.163 P21439 MDR3_HUMAN 86.230 0.452381 0.522551 ABCB4 - Phosphatidylcholine translocator ABCB4 - Homo sapiens (Human) - ABCB4 gene Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571, PubMed:28012258). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity). Taurus_UMD|evm.model.AC_000161.1.164 P08183 MDR1_HUMAN 82.174 0.99451 0.996094 ABCB1 - ATP-dependent translocase ABCB1 - Homo sapiens (Human) - ABCB1 gene Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218). Taurus_UMD|evm.model.AC_000161.1.165 P21440 MDR3_MOUSE 87.432 0.998433 1 Abcb4 - Phosphatidylcholine translocator ABCB4 - Mus musculus (Mouse) - Abcb4 gene Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi between hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:8106172, PubMed:7912658, PubMed:7592705, PubMed:7814632, PubMed:8725158, PubMed:9366571). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (By similarity). Required for proper phospholipid bile formation (PubMed:8106172). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:7814632, PubMed:8725158). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (PubMed:1990275). Taurus_UMD|evm.model.AC_000161.1.166 O19094 OCTC_BOVIN 81.741 0.908451 0.696078 CROT - Peroxisomal carnitine O-octanoyltransferase - Bos taurus (Bovine) - CROT gene Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Taurus_UMD|evm.model.AC_000161.1.167 Q3T160 NPM_BOVIN 93.750 0.854839 0.632653 NPM1 - Nucleophosmin - Bos taurus (Bovine) - NPM1 gene Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. Taurus_UMD|evm.model.AC_000161.1.168 P13084 NPM_RAT 93.846 0.761905 0.287671 Npm1 - Nucleophosmin - Rattus norvegicus (Rat) - Npm1 gene Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. Taurus_UMD|evm.model.AC_000161.1.169 A0JNK6 TM243_BOVIN 85.593 0.980392 0.864407 TMEM243 - Transmembrane protein 243 - Bos taurus (Bovine) - TMEM243 gene Taurus_UMD|evm.model.AC_000161.1.170 Q9Y222 DMTF1_HUMAN 95.407 0.997375 1.00263 DMTF1 - Cyclin-D-binding Myb-like transcription factor 1 - Homo sapiens (Human) - DMTF1 gene Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1. Taurus_UMD|evm.model.AC_000161.1.171 Q5E9I7 MEP50_BOVIN 50.195 0.98913 0.538012 WDR77 - Methylosome protein 50 - Bos taurus (Bovine) - WDR77 gene Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Taurus_UMD|evm.model.AC_000161.1.172 Q1LZG6 CCNB1_BOVIN 88.759 0.994911 0.920375 CCNB1 - G2/mitotic-specific cyclin-B1 - Bos taurus (Bovine) - CCNB1 gene Essential for the control of the cell cycle at the G2/M (mitosis) transition. Taurus_UMD|evm.model.AC_000161.1.173 A7E2Z9 ELAP2_BOVIN 100.000 0.560078 1.075 ELAPOR2 - Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 precursor - Bos taurus (Bovine) - ELAPOR2 gene Functions as a regulator of the BMP signaling pathway and may be involved in epidermal differentiation. Taurus_UMD|evm.model.AC_000161.1.174 Q14832 GRM3_HUMAN 97.270 0.997727 1.00114 GRM3 - Metabotropic glutamate receptor 3 precursor - Homo sapiens (Human) - GRM3 gene G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. Taurus_UMD|evm.model.AC_000161.1.175 O15481 MAGB4_HUMAN 64.368 0.724576 0.682081 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000161.1.177 O95025 SEM3D_HUMAN 95.206 0.997337 0.966538 SEMA3D - Semaphorin-3D precursor - Homo sapiens (Human) - SEMA3D gene Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity). Taurus_UMD|evm.model.AC_000161.1.179 Q63548 SEM3A_RAT 98.230 0.99115 0.146373 Sema3a - Semaphorin-3A precursor - Rattus norvegicus (Rat) - Sema3a gene May be involved in guiding growing axons towards their targets by forming a molecular boundary that instructs axons to engage in the formation of specific nerve tracts. Binds to neuropilin. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity). Taurus_UMD|evm.model.AC_000161.1.180 Q63548 SEM3A_RAT 91.773 0.919929 0.727979 Sema3a - Semaphorin-3A precursor - Rattus norvegicus (Rat) - Sema3a gene May be involved in guiding growing axons towards their targets by forming a molecular boundary that instructs axons to engage in the formation of specific nerve tracts. Binds to neuropilin. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity). Taurus_UMD|evm.model.AC_000161.1.181 O15041 SEM3E_HUMAN 93.290 0.997423 1.00129 SEMA3E - Semaphorin-3E precursor - Homo sapiens (Human) - SEMA3E gene Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity). Taurus_UMD|evm.model.AC_000161.1.182 Q9Y6V0 PCLO_HUMAN 76.157 0.984028 0.219175 PCLO - Protein piccolo - Homo sapiens (Human) - PCLO gene Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (By similarity). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Taurus_UMD|evm.model.AC_000161.1.183 Q9QYX7 PCLO_MOUSE 86.924 0.653333 0.784333 Pclo - Protein piccolo - Mus musculus (Mouse) - Pclo gene Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:19812333). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy (PubMed:28231469) (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Taurus_UMD|evm.model.AC_000161.1.184 P54289 CA2D1_HUMAN 91.321 0.997947 0.441523 CACNA2D1 - Voltage-dependent calcium channel subunit alpha-2/delta-1 precursor - Homo sapiens (Human) - CACNA2D1 gene The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity). Taurus_UMD|evm.model.AC_000161.1.185 Q76BS1 HGF_BOVIN 100.000 0.995896 1.00137 HGF - Hepatocyte growth factor precursor - Bos taurus (Bovine) - HGF gene Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). Taurus_UMD|evm.model.AC_000161.1.186 A6H767 NP1L1_BOVIN 91.049 0.99455 0.938619 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Taurus_UMD|evm.model.AC_000161.1.187 Q99880 H2B1L_HUMAN 93.651 0.984252 1.00794 H2BC13 - Histone H2B type 1-L - Homo sapiens (Human) - H2BC13 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000161.1.188 P62262 1433E_SHEEP 91.935 0.884058 0.270588 YWHAE - 14-3-3 protein epsilon - Ovis aries (Sheep) - YWHAE gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Taurus_UMD|evm.model.AC_000161.1.190 A7MB70 SEM3C_BOVIN 93.342 0.997151 0.934754 SEMA3C - Semaphorin-3C precursor - Bos taurus (Bovine) - SEMA3C gene Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). Taurus_UMD|evm.model.AC_000161.1.191 P26201 CD36_BOVIN 66.507 0.981283 0.792373 CD36 - Platelet glycoprotein 4 - Bos taurus (Bovine) - CD36 gene Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (By similarity). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity). Involved in oral fat perception and preferences (By similarity). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome. Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity). Taurus_UMD|evm.model.AC_000161.1.192 P26201 CD36_BOVIN 100.000 0.995772 1.00212 CD36 - Platelet glycoprotein 4 - Bos taurus (Bovine) - CD36 gene Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (By similarity). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity). Involved in oral fat perception and preferences (By similarity). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome. Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity). Taurus_UMD|evm.model.AC_000161.1.193 P0C7Q4 GNAT3_BOVIN 100.000 0.980545 0.725989 GNAT3 - Guanine nucleotide-binding protein G(t) subunit alpha-3 - Bos taurus (Bovine) - GNAT3 gene Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Taurus_UMD|evm.model.AC_000161.1.194 Q9WTX6 CUL1_MOUSE 78.479 0.997396 0.989691 Cul1 - Cullin-1 - Mus musculus (Mouse) - Cul1 gene Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Taurus_UMD|evm.model.AC_000161.1.195 B2RSH2 GNAI1_MOUSE 100.000 0.994366 1.00282 Gnai1 - Guanine nucleotide-binding protein G(i) subunit alpha-1 - Mus musculus (Mouse) - Gnai1 gene Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis. Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Taurus_UMD|evm.model.AC_000161.1.197 Q86UL8 MAGI2_HUMAN 100.000 0.847458 0.0810997 MAGI2 - Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 - Homo sapiens (Human) - MAGI2 gene Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. Taurus_UMD|evm.model.AC_000161.1.199 Q8CB19 PHTF2_MOUSE 93.842 0.997326 1.00134 Phtf2 - Protein PHTF2 - Mus musculus (Mouse) - Phtf2 gene endoplasmic reticulum Taurus_UMD|evm.model.AC_000161.1.200 Q8K174 TMM60_MOUSE 99.248 0.985075 1.00752 Tmem60 - Transmembrane protein 60 - Mus musculus (Mouse) - Tmem60 gene Taurus_UMD|evm.model.AC_000161.1.201 Q6PCB5 RSBNL_HUMAN 85.950 0.997484 0.939716 RSBN1L - Lysine-specific demethylase RSBN1L - Homo sapiens (Human) - RSBN1L gene Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. Taurus_UMD|evm.model.AC_000161.1.202 Q05209 PTN12_HUMAN 89.668 0.997446 1.00385 PTPN12 - Tyrosine-protein phosphatase non-receptor type 12 - Homo sapiens (Human) - PTPN12 gene Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). Taurus_UMD|evm.model.AC_000161.1.203 P62936 PPIA_PIG 81.707 0.987013 0.939024 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Taurus_UMD|evm.model.AC_000161.1.204 A4D1B5 GSAP_HUMAN 82.126 0.899891 1.07611 GSAP - Gamma-secretase-activating protein - Homo sapiens (Human) - GSAP gene Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. Taurus_UMD|evm.model.AC_000161.1.205 Q8IYE0 CC146_HUMAN 87.866 0.99791 1.00209 CCDC146 - Coiled-coil domain-containing protein 146 - Homo sapiens (Human) - CCDC146 gene centriole, cytoskeleton Taurus_UMD|evm.model.AC_000161.1.206 Q8N0U4 F185A_HUMAN 77.863 0.994819 0.984694 FAM185A - Protein FAM185A - Homo sapiens (Human) - FAM185A gene Taurus_UMD|evm.model.AC_000161.1.207 Q8CDU4 DRC6_MOUSE 70.485 0.729032 0.392405 Fbxl13 - Dynein regulatory complex subunit 6 - Mus musculus (Mouse) - Fbxl13 gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000161.1.208 Q8N6Y2 LRC17_HUMAN 91.610 0.995475 1.00227 LRRC17 - Leucine-rich repeat-containing protein 17 precursor - Homo sapiens (Human) - LRRC17 gene Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity). Taurus_UMD|evm.model.AC_000161.1.209 Q8NEE6 DRC6_HUMAN 62.667 0.375635 0.268027 FBXL13 - Dynein regulatory complex subunit 6 - Homo sapiens (Human) - FBXL13 gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000161.1.210 Q9D0L7 ARM10_MOUSE 78.878 0.974194 1.01307 Armc10 - Armadillo repeat-containing protein 10 - Mus musculus (Mouse) - Armc10 gene May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53 (By similarity). Taurus_UMD|evm.model.AC_000161.1.211 Q58CN9 NAPEP_BOVIN 100.000 0.994911 1.00255 NAPEPLD - N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D - Bos taurus (Bovine) - NAPEPLD gene D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (By similarity). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity). Taurus_UMD|evm.model.AC_000161.1.212 Q3SZ71 MPPB_BOVIN 99.388 0.995927 1.00204 PMPCB - Mitochondrial-processing peptidase subunit beta precursor - Bos taurus (Bovine) - PMPCB gene Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (By similarity). Preferentially, cleaves after an arginine at position P2 (By similarity). Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis (By similarity). Taurus_UMD|evm.model.AC_000161.1.213 Q1RMH9 DNJC2_BOVIN 100.000 0.996785 1.00161 DNAJC2 - DnaJ homolog subfamily C member 2 - Bos taurus (Bovine) - DNAJC2 gene Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Taurus_UMD|evm.model.AC_000161.1.214 Q4R4R0 PRS7_MACFA 100.000 0.995392 1.00231 PSMC2 - 26S proteasome regulatory subunit 7 - Macaca fascicularis (Crab-eating macaque) - PSMC2 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Taurus_UMD|evm.model.AC_000161.1.215 P58743 S26A5_HUMAN 96.211 0.994609 0.997312 SLC26A5 - Prestin - Homo sapiens (Human) - SLC26A5 gene Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity). Taurus_UMD|evm.model.AC_000161.1.217 O43913 ORC5_HUMAN 95.862 0.995413 1.0023 ORC5 - Origin recognition complex subunit 5 - Homo sapiens (Human) - ORC5 gene Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Taurus_UMD|evm.model.AC_000161.1.218 Q86UP9 LHPL3_HUMAN 100.000 0.730769 0.771186 LHFPL3 - LHFPL tetraspan subfamily member 3 protein - Homo sapiens (Human) - LHFPL3 gene membrane, plasma membrane, sensory perception of sound Taurus_UMD|evm.model.AC_000161.1.220 Q86UP9 LHPL3_HUMAN 100.000 0.909091 0.326271 LHFPL3 - LHFPL tetraspan subfamily member 3 protein - Homo sapiens (Human) - LHFPL3 gene membrane, plasma membrane, sensory perception of sound Taurus_UMD|evm.model.AC_000161.1.222 Q8IZD2 KMT2E_HUMAN 92.043 0.9989 0.978471 KMT2E - Inactive histone-lysine N-methyltransferase 2E - Homo sapiens (Human) - KMT2E gene Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:24130829, PubMed:23798402). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:24130829, PubMed:23798402). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). Taurus_UMD|evm.model.AC_000161.1.223 P78362 SRPK2_HUMAN 90.909 0.912807 1.06686 SRPK2 - SRSF protein kinase 2 - Homo sapiens (Human) - SRPK2 gene Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:9472028, PubMed:18559500, PubMed:21056976). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). Taurus_UMD|evm.model.AC_000161.1.224 Q08DI8 PUS7_BOVIN 99.848 0.922861 1.08194 PUS7 - Pseudouridylate synthase 7 homolog - Bos taurus (Bovine) - PUS7 gene Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types. Taurus_UMD|evm.model.AC_000161.1.225 Q6NUQ1 RINT1_HUMAN 92.929 0.997478 1.00126 RINT1 - RAD50-interacting protein 1 - Homo sapiens (Human) - RINT1 gene Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control (PubMed:11096100). Essential for telomere length control (PubMed:16600870). Taurus_UMD|evm.model.AC_000161.1.226 A6NFE3 EFC10_HUMAN 73.387 0.924812 1.04724 EFCAB10 - EF-hand calcium-binding domain-containing protein 10 - Homo sapiens (Human) - EFCAB10 gene Taurus_UMD|evm.model.AC_000161.1.227 Q3T136 AT7L1_BOVIN 97.541 0.115128 7.24828 ATXN7L1 - Ataxin-7-like protein 1 - Bos taurus (Bovine) - ATXN7L1 gene Taurus_UMD|evm.model.AC_000161.1.228 P42558 RAN_CHICK 87.742 0.980769 0.722222 RAN - GTP-binding nuclear protein Ran - Gallus gallus (Chicken) - RAN gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. Taurus_UMD|evm.model.AC_000161.1.229 Q6ZTQ4 CDHR3_HUMAN 78.844 0.994233 0.979661 CDHR3 - Cadherin-related family member 3 precursor - Homo sapiens (Human) - CDHR3 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Taurus_UMD|evm.model.AC_000161.1.230 Q16563 SYPL1_HUMAN 83.012 0.992218 0.992278 SYPL1 - Synaptophysin-like protein 1 - Homo sapiens (Human) - SYPL1 gene extracellular exosome, integral component of membrane, integral component of plasma membrane, synaptic vesicle membrane, syntaxin-1 binding, chemical synaptic transmission Taurus_UMD|evm.model.AC_000161.1.231 Q6J1J1 BIRC5_BOVIN 95.000 0.626984 0.887324 BIRC5 - Baculoviral IAP repeat-containing protein 5 - Bos taurus (Bovine) - BIRC5 gene Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (By similarity). Taurus_UMD|evm.model.AC_000161.1.232 Q52I78 NAMPT_PIG 98.574 0.995935 1.00204 NAMPT - Nicotinamide phosphoribosyltransferase - Sus scrofa (Pig) - NAMPT gene Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. Taurus_UMD|evm.model.AC_000161.1.233 O02697 PK3CG_PIG 93.285 0.998106 0.958258 PIK3CG - Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform - Sus scrofa (Pig) - PIK3CG gene Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Required for B-lymphocyte development and signaling. Together with other PI3Ks are involved in the oxidative burst produced by neutrophils in response to chemotactic agents. Together with PIK3CD regulate neutrophil extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contribute to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis (By similarity). Taurus_UMD|evm.model.AC_000161.1.234 P31322 KAP3_BOVIN 99.522 0.995227 1.00239 PRKAR2B - cAMP-dependent protein kinase type II-beta regulatory subunit - Bos taurus (Bovine) - PRKAR2B gene Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. Taurus_UMD|evm.model.AC_000161.1.235 Q2KJ34 HBP1_BOVIN 99.805 0.977055 1.02148 HBP1 - HMG box-containing protein 1 - Bos taurus (Bovine) - HBP1 gene Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity). Taurus_UMD|evm.model.AC_000161.1.236 Q9UP83 COG5_HUMAN 82.047 0.962617 0.765197 COG5 - Conserved oligomeric Golgi complex subunit 5 - Homo sapiens (Human) - COG5 gene Required for normal Golgi function. Taurus_UMD|evm.model.AC_000161.1.237 O95620 DUS4L_HUMAN 91.798 0.984424 1.01262 DUS4L - tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like - Homo sapiens (Human) - DUS4L gene Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Taurus_UMD|evm.model.AC_000161.1.238 Q32KL9 BAP29_BOVIN 100.000 0.991701 1.00417 BCAP29 - B-cell receptor-associated protein 29 - Bos taurus (Bovine) - BCAP29 gene May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity). Taurus_UMD|evm.model.AC_000161.1.239 O43511 S26A4_HUMAN 88.630 0.941535 1.05256 SLC26A4 - Pendrin - Homo sapiens (Human) - SLC26A4 gene Sodium-independent transporter of chloride and iodide. Taurus_UMD|evm.model.AC_000161.1.240 Q75N03 HAKAI_HUMAN 97.764 0.995943 1.00407 CBLL1 - E3 ubiquitin-protein ligase Hakai - Homo sapiens (Human) - CBLL1 gene E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755). Taurus_UMD|evm.model.AC_000161.1.241 Q924C9 S26A3_RAT 84.079 0.997372 1.00528 Slc26a3 - Chloride anion exchanger - Rattus norvegicus (Rat) - Slc26a3 gene Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity). Taurus_UMD|evm.model.AC_000161.1.242 P49819 DLDH_CANLF 97.839 0.996078 1.00196 DLD - Dihydrolipoyl dehydrogenase, mitochondrial precursor - Canis lupus familiaris (Dog) - DLD gene Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease (By similarity). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). Taurus_UMD|evm.model.AC_000161.1.243 Q01635 LAMB1_CHICK 92.079 0.174365 5.71617 LAMB1 - Laminin subunit beta-1 - Gallus gallus (Chicken) - LAMB1 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Taurus_UMD|evm.model.AC_000161.1.244 A4D0S4 LAMB4_HUMAN 50.294 0.994937 0.224304 LAMB4 - Laminin subunit beta-4 precursor - Homo sapiens (Human) - LAMB4 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Taurus_UMD|evm.model.AC_000161.1.245 A4D0S4 LAMB4_HUMAN 63.415 0.624309 0.102783 LAMB4 - Laminin subunit beta-4 precursor - Homo sapiens (Human) - LAMB4 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Taurus_UMD|evm.model.AC_000161.1.246 A4D0S4 LAMB4_HUMAN 76.733 0.62069 0.181147 LAMB4 - Laminin subunit beta-4 precursor - Homo sapiens (Human) - LAMB4 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Taurus_UMD|evm.model.AC_000161.1.247 Q01635 LAMB1_CHICK 66.667 0.0976864 1.28383 LAMB1 - Laminin subunit beta-1 - Gallus gallus (Chicken) - LAMB1 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Taurus_UMD|evm.model.AC_000161.1.248 Q92823 NRCAM_HUMAN 93.615 0.877888 0.929448 NRCAM - Neuronal cell adhesion molecule precursor - Homo sapiens (Human) - NRCAM gene Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. Taurus_UMD|evm.model.AC_000161.1.249 Q9NP80 PLPL8_HUMAN 88.408 0.997452 1.00384 PNPLA8 - Calcium-independent phospholipase A2-gamma - Homo sapiens (Human) - PNPLA8 gene Calcium-independent phospholipase A2, which promotes cellular membrane hydrolysis and prostaglandin production (PubMed:10744668, PubMed:15695510). Catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, phosphytidylserine and to a lower extent phosphatidylcholine (PubMed:10744668). Cleaves membrane phospholipids (PubMed:15695510). Participates in the generation of lipid second messengers through the mobilization of arachidonic acid in response to cellular stimuli. Synthesizes 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling (PubMed:15908428). Participates in the lipid plasticity of myocardium, plays a role in the generation of signaling metabolites and has a prominent effect on the modulaton of energy storage and utilization (PubMed:17213206). Essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition (By similarity). Taurus_UMD|evm.model.AC_000161.1.250 Q7Z602 GP141_HUMAN 36.400 0.983936 0.816393 GPR141 - Probable G-protein coupled receptor 141 - Homo sapiens (Human) - GPR141 gene Orphan receptor. Taurus_UMD|evm.model.AC_000161.1.251 Q8N427 TXND3_HUMAN 67.869 0.958403 1.02211 NME8 - Thioredoxin domain-containing protein 3 - Homo sapiens (Human) - NME8 gene Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. Taurus_UMD|evm.model.AC_000161.1.252 Q6FHJ7 SFRP4_HUMAN 95.954 0.994236 1.00289 SFRP4 - Secreted frizzled-related protein 4 precursor - Homo sapiens (Human) - SFRP4 gene Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927). Taurus_UMD|evm.model.AC_000161.1.253 A6QLI0 EPDR1_BOVIN 100.000 0.991561 1.00424 EPDR1 - Mammalian ependymin-related protein 1 precursor - Bos taurus (Bovine) - EPDR1 gene Binds anionic lipids and gangliosides at acidic pH. Taurus_UMD|evm.model.AC_000161.1.254 O95772 STR3N_HUMAN 97.021 0.991525 1.00855 STARD3NL - STARD3 N-terminal-like protein - Homo sapiens (Human) - STARD3NL gene Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263). Taurus_UMD|evm.model.AC_000161.1.255 P03986 TRGC2_HUMAN 55.072 0.562842 1.93651 TRGC2 - T cell receptor gamma constant 2 - Homo sapiens (Human) - TRGC2 gene Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000161.1.256 P01853 TCC1_MOUSE 64.912 0.548544 1.23353 T-cell receptor gamma chain C region C10.5 - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000161.1.257 Q09YI1 CTTB2_SHEEP 97.686 0.998783 1.00122 CTTNBP2 - Cortactin-binding protein 2 - Ovis aries (Sheep) - CTTNBP2 gene Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance. Taurus_UMD|evm.model.AC_000161.1.258 P35071 CFTR_BOVIN 97.473 0.977413 0.986496 CFTR - Cystic fibrosis transmembrane conductance regulator - Bos taurus (Bovine) - CFTR gene Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity). Taurus_UMD|evm.model.AC_000161.1.259 Q09YI4 WNT2_SHEEP 100.000 0.515576 1.78333 WNT2 - Protein Wnt-2 precursor - Ovis aries (Sheep) - WNT2 gene Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). Taurus_UMD|evm.model.AC_000161.1.260 Q2IBD0 ST7_RAT 99.480 0.99654 1.00173 St7 - Suppressor of tumorigenicity 7 protein - Rattus norvegicus (Rat) - St7 gene Taurus_UMD|evm.model.AC_000161.1.261 Q09YJ9 CAZA2_MUNMU 92.657 0.992481 0.93007 CAPZA2 - F-actin-capping protein subunit alpha-2 - Muntiacus muntjak (Barking deer) - CAPZA2 gene F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). Taurus_UMD|evm.model.AC_000161.1.262 Q769I5 MET_BOVIN 97.919 0.665835 0.86922 MET - Hepatocyte growth factor receptor precursor - Bos taurus (Bovine) - MET gene Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity). Taurus_UMD|evm.model.AC_000161.1.263 Q6B3Y2 CAV1_SHEEP 100.000 0.988827 1.00562 CAV1 - Caveolin-1 - Ovis aries (Sheep) - CAV1 gene May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity). Taurus_UMD|evm.model.AC_000161.1.264 Q66WT7 CAV2_BOVIN 100.000 0.98773 1.00617 CAV2 - Caveolin-2 - Bos taurus (Bovine) - CAV2 gene May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity). Taurus_UMD|evm.model.AC_000161.1.265 Q2YDE9 TES_BOVIN 100.000 0.995157 0.980998 TES - Testin - Bos taurus (Bovine) - TES gene Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity). Taurus_UMD|evm.model.AC_000161.1.266 A4IFU7 TFEC_BOVIN 99.685 0.993711 1.00315 TFEC - Transcription factor EC - Bos taurus (Bovine) - TFEC gene Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer. Binds DNA in a homo- or heterodimeric form (By similarity). Taurus_UMD|evm.model.AC_000161.1.267 Q9P1T7 MDFIC_HUMAN 89.024 0.785016 1.24797 MDFIC - MyoD family inhibitor domain-containing protein - Homo sapiens (Human) - MDFIC gene Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. Taurus_UMD|evm.model.AC_000161.1.269 Q8MJ99 FOXP2_GORGO 85.185 0.996522 0.806452 FOXP2 - Forkhead box protein P2 - Gorilla gorilla gorilla (Western lowland gorilla) - FOXP2 gene Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). Taurus_UMD|evm.model.AC_000161.1.270 Q8MJA0 FOXP2_PANTR 96.667 0.794643 0.156425 FOXP2 - Forkhead box protein P2 - Pan troglodytes (Chimpanzee) - FOXP2 gene Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity). Taurus_UMD|evm.model.AC_000161.1.271 Q00756 PPR3A_RABIT 81.923 0.234389 0.996393 PPP1R3A - Protein phosphatase 1 regulatory subunit 3A - Oryctolagus cuniculus (Rabbit) - PPP1R3A gene Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity). Taurus_UMD|evm.model.AC_000161.1.272 Q4R4Z6 RS3A_MACFA 83.721 0.488372 0.325758 RPS3A - 40S ribosomal protein S3a - Macaca fascicularis (Crab-eating macaque) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Taurus_UMD|evm.model.AC_000161.1.274 P60895 GPR85_RAT 99.730 0.994609 1.0027 Gpr85 - Probable G-protein coupled receptor 85 - Rattus norvegicus (Rat) - Gpr85 gene Orphan receptor. Taurus_UMD|evm.model.AC_000161.1.275 A5PK14 LSME1_BOVIN 99.219 0.984496 1.00781 LSMEM1 - Leucine-rich single-pass membrane protein 1 - Bos taurus (Bovine) - LSMEM1 gene Taurus_UMD|evm.model.AC_000161.1.276 Q5S1U6 IFRD1_PIG 96.889 0.995565 1.00222 IFRD1 - Interferon-related developmental regulator 1 - Sus scrofa (Pig) - IFRD1 gene Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity). Taurus_UMD|evm.model.AC_000161.1.277 Q9NRM2 ZN277_HUMAN 83.333 0.924945 1.00667 ZNF277 - Zinc finger protein 277 - Homo sapiens (Human) - ZNF277 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000161.1.278 Q1RMZ1 SAMTR_HUMAN 96.296 0.995074 1.00247 BMT2 - S-adenosylmethionine sensor upstream of mTORC1 - Homo sapiens (Human) - BMT2 gene S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential). Taurus_UMD|evm.model.AC_000161.1.279 A0JNG0 TM168_BOVIN 100.000 0.997135 1.00143 TMEM168 - Transmembrane protein 168 - Bos taurus (Bovine) - TMEM168 gene Taurus_UMD|evm.model.AC_000161.1.280 P31948 STIP1_HUMAN 50.000 0.740876 0.504604 STIP1 - Stress-induced-phosphoprotein 1 - Homo sapiens (Human) - STIP1 gene Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). Taurus_UMD|evm.model.AC_000161.1.281 Q8N1I0 DOCK4_HUMAN 97.892 0.998757 0.818413 DOCK4 - Dedicator of cytokinesis protein 4 - Homo sapiens (Human) - DOCK4 gene Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). Taurus_UMD|evm.model.AC_000161.1.282 Q8VH49 HIG1A_RAT 84.946 0.978723 1.01075 Higd1a - HIG1 domain family member 1A, mitochondrial - Rattus norvegicus (Rat) - Higd1a gene Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). Taurus_UMD|evm.model.AC_000161.1.283 Q9H3W5 LRRN3_HUMAN 93.079 0.997179 1.00141 LRRN3 - Leucine-rich repeat neuronal protein 3 precursor - Homo sapiens (Human) - LRRN3 gene extracellular matrix, extracellular space Taurus_UMD|evm.model.AC_000161.1.284 Q0P5H5 RGS2_BOVIN 100.000 0.990566 1.00474 RGS2 - Regulator of G-protein signaling 2 - Bos taurus (Bovine) - RGS2 gene Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity). Taurus_UMD|evm.model.AC_000161.1.285 Q10126 YSM6_CAEEL 27.668 0.818505 1.00717 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000161.1.287 Q9UPT8 ZC3H4_HUMAN 55.102 0.607595 0.0606293 ZC3H4 - Zinc finger CCCH domain-containing protein 4 - Homo sapiens (Human) - ZC3H4 gene cytosol, nucleoplasm, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA binding Taurus_UMD|evm.model.AC_000161.1.288 Q7YRC1 AIP_BOVIN 78.261 0.381356 0.357576 AIP - AH receptor-interacting protein - Bos taurus (Bovine) - AIP gene May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Taurus_UMD|evm.model.AC_000161.1.289 Q9QYI6 DNJB9_MOUSE 94.619 0.95279 1.04955 Dnajb9 - DnaJ homolog subfamily B member 9 precursor - Mus musculus (Mouse) - Dnajb9 gene Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:11836248). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:22267725). Required for survival of B-cell progenitors and normal antibody production (PubMed:25222125). Taurus_UMD|evm.model.AC_000161.1.290 Q1RMM0 THAP5_BOVIN 99.747 0.994949 1.00508 THAP5 - THAP domain-containing protein 5 - Bos taurus (Bovine) - THAP5 gene Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase. Taurus_UMD|evm.model.AC_000161.1.291 Q86W50 MET16_HUMAN 76.289 0.96 0.177936 METTL16 - RNA N6-adenosine-methyltransferase METTL16 - Homo sapiens (Human) - METTL16 gene RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197299, PubMed:30197297). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197299, PubMed:30197297). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing and/or stability of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression (PubMed:28525753). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). Taurus_UMD|evm.model.AC_000161.1.292 Q7Z602 GP141_HUMAN 80.328 0.993421 0.996721 GPR141 - Probable G-protein coupled receptor 141 - Homo sapiens (Human) - GPR141 gene Orphan receptor. Taurus_UMD|evm.model.AC_000161.1.293 Q92556 ELMO1_HUMAN 99.587 0.997253 1.00138 ELMO1 - Engulfment and cell motility protein 1 - Homo sapiens (Human) - ELMO1 gene Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. Taurus_UMD|evm.model.AC_000161.1.294 P62083 RS7_RAT 76.821 0.986755 0.778351 Rps7 - 40S ribosomal protein S7 - Rattus norvegicus (Rat) - Rps7 gene Required for rRNA maturation. Taurus_UMD|evm.model.AC_000161.1.295 P28039 AOAH_HUMAN 80.348 0.996528 1.00174 AOAH - Acyloxyacyl hydrolase precursor - Homo sapiens (Human) - AOAH gene Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (PubMed:1883828, PubMed:8089145, PubMed:29343645). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity). Taurus_UMD|evm.model.AC_000161.1.296 Q9NQW6 ANLN_HUMAN 86.421 0.998197 0.986655 ANLN - Anillin - Homo sapiens (Human) - ANLN gene Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). Taurus_UMD|evm.model.AC_000161.1.297 Q7TQE7 K0895_MOUSE 85.605 0.994253 1.00578 Kiaa0895 - Uncharacterized protein KIAA0895 - Mus musculus (Mouse) - Kiaa0895 gene Taurus_UMD|evm.model.AC_000161.1.298 Q3MHJ7 EEPD1_BOVIN 100.000 0.996503 1.00175 EEPD1 - Endonuclease/exonuclease/phosphatase family domain-containing protein 1 - Bos taurus (Bovine) - EEPD1 gene Taurus_UMD|evm.model.AC_000161.1.299 Q5R481 SEPT7_PONAB 100.000 0.995434 1.00229 SEPTIN7 - Septin-7 - Pongo abelii (Sumatran orangutan) - SEPTIN7 gene Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Taurus_UMD|evm.model.AC_000161.1.301 Q0P5H8 HERP2_BOVIN 100.000 0.995086 1.00246 HERPUD2 - Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein - Bos taurus (Bovine) - HERPUD2 gene Could be involved in the unfolded protein response (UPR) pathway. Taurus_UMD|evm.model.AC_000161.1.302 P62878 RBX1_MOUSE 98.077 0.980952 0.972222 Rbx1 - E3 ubiquitin-protein ligase RBX1 - Mus musculus (Mouse) - Rbx1 gene E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:22118460). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components (By similarity). As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate (By similarity). Probably also stimulates CDC34 autoubiquitination (By similarity). May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair (By similarity). Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M (By similarity). Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (By similarity). In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM (By similarity). Taurus_UMD|evm.model.AC_000161.1.304 Q9UMR3 TBX20_HUMAN 91.537 0.995238 0.939597 TBX20 - T-box transcription factor TBX20 - Homo sapiens (Human) - TBX20 gene Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart. Taurus_UMD|evm.model.AC_000161.1.305 Q6NUT2 D19L2_HUMAN 82.378 0.922481 1.02111 DPY19L2 - Probable C-mannosyltransferase DPY19L2 - Homo sapiens (Human) - DPY19L2 gene Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for sperm head elongation and acrosome formation. Taurus_UMD|evm.model.AC_000161.1.306 Q2PZI1 D19L1_HUMAN 96.600 0.862483 1.10963 DPY19L1 - Probable C-mannosyltransferase DPY19L1 - Homo sapiens (Human) - DPY19L1 gene Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Taurus_UMD|evm.model.AC_000161.1.307 Q56H79 NPSR1_MACMU 92.701 0.944637 0.778976 NPSR1 - Neuropeptide S receptor - Macaca mulatta (Rhesus macaque) - NPSR1 gene G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases. Taurus_UMD|evm.model.AC_000161.1.308 Q56H79 NPSR1_MACMU 79.592 0.394958 0.320755 NPSR1 - Neuropeptide S receptor - Macaca mulatta (Rhesus macaque) - NPSR1 gene G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases. Taurus_UMD|evm.model.AC_000161.1.309 Q8N8U9 BMPER_HUMAN 94.745 0.997085 1.00146 BMPER - BMP-binding endothelial regulator protein precursor - Homo sapiens (Human) - BMPER gene Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. Taurus_UMD|evm.model.AC_000161.1.310 P14381 YTX2_XENLA 26.429 0.52459 0.186544 Transposon TX1 uncharacterized 149 kDa protein - Xenopus laevis (African clawed frog) Taurus_UMD|evm.model.AC_000161.1.312 Q3SYG4 PTHB1_HUMAN 90.528 0.997297 0.834273 BBS9 - Protein PTHB1 - Homo sapiens (Human) - BBS9 gene The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization. Taurus_UMD|evm.model.AC_000161.1.313 P97762 RP9_MOUSE 93.590 0.698198 1.04225 rp9 - Retinitis pigmentosa 9 protein homolog - Mus musculus (Mouse) - rp9 gene Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1. Taurus_UMD|evm.model.AC_000161.1.315 Q9H0P0 5NT3A_HUMAN 92.145 0.993976 0.988095 NT5C3A - Cytosolic 5'-nucleotidase 3A - Homo sapiens (Human) - NT5C3A gene Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) (PubMed:24603684). CMP seems to be the preferred substrate (PubMed:15968458). Taurus_UMD|evm.model.AC_000161.1.316 Q2KJC8 FKBP9_BOVIN 100.000 0.996522 1.00174 FKBP9 - Peptidyl-prolyl cis-trans isomerase FKBP9 precursor - Bos taurus (Bovine) - FKBP9 gene PPIases accelerate the folding of proteins during protein synthesis. Taurus_UMD|evm.model.AC_000161.1.319 Q8IY47 KBTB2_HUMAN 98.074 0.996795 1.00161 KBTBD2 - Kelch repeat and BTB domain-containing protein 2 - Homo sapiens (Human) - KBTBD2 gene Taurus_UMD|evm.model.AC_000161.1.320 Q8NBF6 AVL9_HUMAN 92.892 0.958075 0.993827 AVL9 - Late secretory pathway protein AVL9 homolog - Homo sapiens (Human) - AVL9 gene Functions in cell migration. Taurus_UMD|evm.model.AC_000161.1.321 Q5R628 LSM5_PONAB 93.548 0.743902 0.901099 LSM5 - U6 snRNA-associated Sm-like protein LSm5 - Pongo abelii (Sumatran orangutan) - LSM5 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Taurus_UMD|evm.model.AC_000161.1.325 Q63421 PDE1C_RAT 89.189 0.839695 0.170573 Pde1c - Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C - Rattus norvegicus (Rat) - Pde1c gene Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP (PubMed:7568196). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (By similarity). Taurus_UMD|evm.model.AC_000161.1.326 Q14123 PDE1C_HUMAN 95.500 0.996672 0.847673 PDE1C - Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C - Homo sapiens (Human) - PDE1C gene Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8557689, PubMed:29860631). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). Taurus_UMD|evm.model.AC_000161.1.327 O96001 PPR17_HUMAN 92.258 0.987179 1.00645 PPP1R17 - Protein phosphatase 1 regulatory subunit 17 - Homo sapiens (Human) - PPP1R17 gene Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes. Taurus_UMD|evm.model.AC_000161.1.328 Q6ZRS4 ITPI1_HUMAN 64.486 0.212579 0.761494 ITPRID1 - Protein ITPRID1 - Homo sapiens (Human) - ITPRID1 gene Taurus_UMD|evm.model.AC_000161.1.329 Q08DI0 NDF6_BOVIN 100.000 0.994083 1.00297 NEUROD6 - Neurogenic differentiation factor 6 - Bos taurus (Bovine) - NEUROD6 gene Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity). Taurus_UMD|evm.model.AC_000161.1.330 Q29627 PACR_BOVIN 100.000 0.996109 1.00195 ADCYAP1R1 - Pituitary adenylate cyclase-activating polypeptide type I receptor precursor - Bos taurus (Bovine) - ADCYAP1R1 gene This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (By similarity). Taurus_UMD|evm.model.AC_000161.1.332 P34999 GHRHR_PIG 87.441 0.956818 1.04019 GHRHR - Growth hormone-releasing hormone receptor precursor - Sus scrofa (Pig) - GHRHR gene Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Taurus_UMD|evm.model.AC_000161.1.333 P47865 AQP1_BOVIN 100.000 0.992647 1.00369 AQP1 - Aquaporin-1 - Bos taurus (Bovine) - AQP1 gene Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Taurus_UMD|evm.model.AC_000161.1.334 A1A4L4 MINY4_BOVIN 99.869 0.997382 1.00131 MINDY4 - Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 - Bos taurus (Bovine) - MINDY4 gene Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. Taurus_UMD|evm.model.AC_000161.1.335 P40936 INMT_MOUSE 68.561 0.992424 1 Inmt - Indolethylamine N-methyltransferase - Mus musculus (Mouse) - Inmt gene Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity). Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds. Taurus_UMD|evm.model.AC_000161.1.336 Q13324 CRFR2_HUMAN 95.767 0.8627 1.06326 CRHR2 - Corticotropin-releasing factor receptor 2 - Homo sapiens (Human) - CRHR2 gene G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Taurus_UMD|evm.model.AC_000161.1.337 Q5RBL1 GARS_PONAB 86.991 0.997253 0.985115 GARS1 - Glycine--tRNA ligase precursor - Pongo abelii (Sumatran orangutan) - GARS1 gene Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. Taurus_UMD|evm.model.AC_000161.1.338 Q32LE4 GGCT_BOVIN 100.000 0.989418 1.00532 GGCT - Gamma-glutamylcyclotransferase - Bos taurus (Bovine) - GGCT gene Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Taurus_UMD|evm.model.AC_000161.1.339 Q9Y239 NOD1_HUMAN 83.229 0.997906 1.0021 NOD1 - Nucleotide-binding oligomerization domain-containing protein 1 - Homo sapiens (Human) - NOD1 gene Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection. Taurus_UMD|evm.model.AC_000161.1.340 Q8NHG8 ZNRF2_HUMAN 88.525 0.991632 0.987603 ZNRF2 - E3 ubiquitin-protein ligase ZNRF2 - Homo sapiens (Human) - ZNRF2 gene May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Taurus_UMD|evm.model.AC_000161.1.341 Q8N3F0 MTURN_HUMAN 100.000 0.984848 1.00763 MTURN - Maturin - Homo sapiens (Human) - MTURN gene Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (PubMed:24681962). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser-536' (PubMed:24681962). May be involved in early neuronal development (By similarity). Taurus_UMD|evm.model.AC_000161.1.342 F1MS15 PKHA8_BOVIN 100.000 0.996161 1.00192 PLEKHA8 - Pleckstrin homology domain-containing family A member 8 - Bos taurus (Bovine) - PLEKHA8 gene Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity). Taurus_UMD|evm.model.AC_000161.1.343 Q5R941 FKB14_PONAB 96.682 0.990566 1.00474 FKBP14 - Peptidyl-prolyl cis-trans isomerase FKBP14 precursor - Pongo abelii (Sumatran orangutan) - FKBP14 gene PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens. Taurus_UMD|evm.model.AC_000161.1.344 P83939 SCRN1_BOVIN 100.000 0.995181 1.00242 SCRN1 - Secernin-1 - Bos taurus (Bovine) - SCRN1 gene Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium. Taurus_UMD|evm.model.AC_000161.1.345 A6NGB9 WIPF3_HUMAN 84.581 0.926078 1.00828 WIPF3 - WAS/WASL-interacting protein family member 3 - Homo sapiens (Human) - WIPF3 gene May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity). Taurus_UMD|evm.model.AC_000161.1.346 Q8IV56 PRR15_HUMAN 78.295 0.984252 0.984496 PRR15 - Proline-rich protein 15 - Homo sapiens (Human) - PRR15 gene May have a role in proliferation and/or differentiation. Taurus_UMD|evm.model.AC_000161.1.347 Q1JQC1 MFSD1_BOVIN 49.351 0.437086 0.32265 MFSD1 - Major facilitator superfamily domain-containing protein 1 - Bos taurus (Bovine) - MFSD1 gene Lysosomal transporter which is essential for liver homeostasis. Required to maintain stability and lysosomal localization of GLMP. Taurus_UMD|evm.model.AC_000161.1.348 Q80XD1 CHIO_MOUSE 98.917 0.588486 1.41265 Chn2 - Beta-chimaerin - Mus musculus (Mouse) - Chn2 gene GTPase-activating protein for p21-rac. Taurus_UMD|evm.model.AC_000161.1.349 Q9H3G5 CPVL_HUMAN 63.554 0.997375 0.80042 CPVL - Probable serine carboxypeptidase CPVL precursor - Homo sapiens (Human) - CPVL gene May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. Taurus_UMD|evm.model.AC_000161.1.350 Q7L0X0 TRIL_HUMAN 90.025 0.997534 1 TRIL - TLR4 interactor with leucine rich repeats precursor - Homo sapiens (Human) - TRIL gene Component of the TLR4 signaling complex. Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion. Taurus_UMD|evm.model.AC_000161.1.352 Q02930 CREB5_HUMAN 97.006 0.996016 0.988189 CREB5 - Cyclic AMP-responsive element-binding protein 5 - Homo sapiens (Human) - CREB5 gene Binds to the cAMP response element and activates transcription. Taurus_UMD|evm.model.AC_000161.1.353 Q5RDF5 JAZF1_PONAB 100.000 0.991803 1.00412 JAZF1 - Juxtaposed with another zinc finger protein 1 - Pongo abelii (Sumatran orangutan) - JAZF1 gene Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD. Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue. Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity. Taurus_UMD|evm.model.AC_000161.1.354 Q2KJE0 TAXB1_BOVIN 100.000 0.997555 1.00122 TAX1BP1 - Tax1-binding protein 1 homolog - Bos taurus (Bovine) - TAX1BP1 gene Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity). Taurus_UMD|evm.model.AC_000161.1.356 P62828 RAN_RAT 100.000 0.32967 0.421296 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Taurus_UMD|evm.model.AC_000161.1.357 Q2HJD7 3HIDH_BOVIN 100.000 0.994065 1.00298 HIBADH - 3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - HIBADH gene mitochondrion, 3-hydroxyisobutyrate dehydrogenase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, valine catabolic process Taurus_UMD|evm.model.AC_000161.1.359 P49640 EVX1_HUMAN 93.366 0.995062 0.995086 EVX1 - Homeobox even-skipped homolog protein 1 - Homo sapiens (Human) - EVX1 gene May play a role in the specification of neuronal cell types. Taurus_UMD|evm.model.AC_000161.1.361 P31271 HXA13_HUMAN 99.024 0.990291 0.530928 HOXA13 - Homeobox protein Hox-A13 - Homo sapiens (Human) - HOXA13 gene Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000161.1.363 P31270 HXA11_HUMAN 97.213 0.416058 2.1885 HOXA11 - Homeobox protein Hox-A11 - Homo sapiens (Human) - HOXA11 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000161.1.364 P09631 HXA9_MOUSE 98.162 0.992674 1.00738 Hoxa9 - Homeobox protein Hox-A9 - Mus musculus (Mouse) - Hoxa9 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). Taurus_UMD|evm.model.AC_000161.1.365 P31268 HXA7_HUMAN 94.737 0.470149 1.74783 HOXA7 - Homeobox protein Hox-A7 - Homo sapiens (Human) - HOXA7 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000161.1.366 P31267 HXA6_HUMAN 97.854 0.991453 1.00429 HOXA6 - Homeobox protein Hox-A6 - Homo sapiens (Human) - HOXA6 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000161.1.367 Q2HJ67 HXA5_BOVIN 100.000 0.704188 1.41481 HOXA5 - Homeobox protein Hox-A5 - Bos taurus (Bovine) - HOXA5 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity). Taurus_UMD|evm.model.AC_000161.1.368 Q00056 HXA4_HUMAN 87.578 0.99375 1 HOXA4 - Homeobox protein Hox-A4 - Homo sapiens (Human) - HOXA4 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'. Taurus_UMD|evm.model.AC_000161.1.369 Q08DG7 HXA3_BOVIN 100.000 0.995485 1.00226 HOXA3 - Homeobox protein Hox-A3 - Bos taurus (Bovine) - HOXA3 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000161.1.370 Q0VCS4 HXA2_BOVIN 99.731 0.994638 1.00269 HOXA2 - Homeobox protein Hox-A2 - Bos taurus (Bovine) - HOXA2 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000161.1.371 P49639 HXA1_HUMAN 93.750 0.901198 0.997015 HOXA1 - Homeobox protein Hox-A1 - Homo sapiens (Human) - HOXA1 gene Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed:16155570). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity). Taurus_UMD|evm.model.AC_000161.1.372 Q32LP7 SKAP2_BOVIN 100.000 0.994429 1.00279 SKAP2 - Src kinase-associated phosphoprotein 2 - Bos taurus (Bovine) - SKAP2 gene May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway (By similarity). Taurus_UMD|evm.model.AC_000161.1.373 Q0IIL5 SNX10_BOVIN 100.000 0.99005 1.005 SNX10 - Sorting nexin-10 - Bos taurus (Bovine) - SNX10 gene Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption (By similarity). Taurus_UMD|evm.model.AC_000161.1.374 Q5R6X7 CBX3_PONAB 100.000 0.878049 0.448087 CBX3 - Chromobox protein homolog 3 - Pongo abelii (Sumatran orangutan) - CBX3 gene Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs). Taurus_UMD|evm.model.AC_000161.1.375 P22626 ROA2_HUMAN 100.000 0.99435 1.00283 HNRNPA2B1 - Heterogeneous nuclear ribonucleoproteins A2/B1 - Homo sapiens (Human) - HNRNPA2B1 gene Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays also a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). Taurus_UMD|evm.model.AC_000161.1.376 Q9Y4A8 NF2L3_HUMAN 79.236 0.668301 0.881844 NFE2L3 - Nuclear factor erythroid 2-related factor 3 - Homo sapiens (Human) - NFE2L3 gene Activates erythroid-specific, globin gene expression. Taurus_UMD|evm.model.AC_000161.1.377 Q9C075 K1C23_HUMAN 65.934 0.538922 0.395735 KRT23 - Keratin, type I cytoskeletal 23 - Homo sapiens (Human) - KRT23 gene cytosol, cornification, keratinization Taurus_UMD|evm.model.AC_000161.1.378 Q9GM96 NPVF_BOVIN 100.000 0.98895 0.923469 NPVF - Pro-FMRFamide-related neuropeptide VF precursor - Bos taurus (Bovine) - NPVF gene Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptide NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide NPVF blocks morphine-induced analgesia (By similarity). Taurus_UMD|evm.model.AC_000161.1.379 Q8N865 CG031_HUMAN 82.881 0.996581 0.991525 C7orf31 - Uncharacterized protein C7orf31 - Homo sapiens (Human) - C7orf31 gene centrosome Taurus_UMD|evm.model.AC_000161.1.381 P62896 CYC_SHEEP 100.000 0.981132 1.00952 CYCS - Cytochrome c - Ovis aries (Sheep) - CYCS gene Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Taurus_UMD|evm.model.AC_000161.1.382 Q9H4L5 OSBL3_HUMAN 93.341 0.997745 1 OSBPL3 - Oxysterol-binding protein-related protein 3 - Homo sapiens (Human) - OSBPL3 gene Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). Taurus_UMD|evm.model.AC_000161.1.383 Q5RDL6 EID1_PONAB 85.864 0.989583 1.02128 EID1 - EP300-interacting inhibitor of differentiation 1 - Pongo abelii (Sumatran orangutan) - EID1 gene Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms (By similarity). Taurus_UMD|evm.model.AC_000161.1.384 Q7YS54 GSDME_HORSE 88.806 0.320482 0.83501 GSDME - Gasdermin-E - Equus caballus (Horse) - GSDME gene Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis. Taurus_UMD|evm.model.AC_000161.1.386 Q9NZW5 MPP6_HUMAN 99.074 0.863782 1.15556 PALS2 - Protein PALS2 - Homo sapiens (Human) - PALS2 gene extracellular exosome, membrane, protein-containing complex assembly Taurus_UMD|evm.model.AC_000161.1.387 Q6RUW3 NPY_BOVIN 98.913 0.957895 0.979381 NPY - Pro-neuropeptide Y precursor - Bos taurus (Bovine) - NPY gene NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Taurus_UMD|evm.model.AC_000161.1.388 Q9BXU1 STK31_HUMAN 83.595 0.998037 1 STK31 - Serine/threonine-protein kinase 31 - Homo sapiens (Human) - STK31 gene cytoplasm, nucleus, nuclease activity Taurus_UMD|evm.model.AC_000161.1.389 A4D161 F221A_HUMAN 89.597 0.993289 1 FAM221A - Protein FAM221A - Homo sapiens (Human) - FAM221A gene Taurus_UMD|evm.model.AC_000161.1.390 Q9P0K1 ADA22_HUMAN 86.719 0.863946 0.162252 ADAM22 - Disintegrin and metalloproteinase domain-containing protein 22 precursor - Homo sapiens (Human) - ADAM22 gene Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. Taurus_UMD|evm.model.AC_000161.1.391 Q9P0K1 ADA22_HUMAN 88.550 0.824798 0.818985 ADAM22 - Disintegrin and metalloproteinase domain-containing protein 22 precursor - Homo sapiens (Human) - ADAM22 gene Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. Taurus_UMD|evm.model.AC_000161.1.392 Q5R4U9 SORCN_PONAB 98.990 0.98995 1.00505 SRI - Sorcin - Pongo abelii (Sumatran orangutan) - SRI gene Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels (By similarity). Taurus_UMD|evm.model.AC_000161.1.393 Q687X5 STEA4_HUMAN 86.275 0.972399 1.02614 STEAP4 - Metalloreductase STEAP4 - Homo sapiens (Human) - STEAP4 gene Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193). Taurus_UMD|evm.model.AC_000161.1.395 Q8TBZ9 TEX47_HUMAN 76.680 0.992095 1 TEX47 - Testis-expressed protein 47 - Homo sapiens (Human) - TEX47 gene Taurus_UMD|evm.model.AC_000161.1.396 A4D1E1 Z804B_HUMAN 92.000 0.604938 0.0600445 ZNF804B - Zinc finger protein 804B - Homo sapiens (Human) - ZNF804B gene nucleus Taurus_UMD|evm.model.AC_000161.1.397 A4D1E1 Z804B_HUMAN 73.934 0.967816 0.967383 ZNF804B - Zinc finger protein 804B - Homo sapiens (Human) - ZNF804B gene nucleus Taurus_UMD|evm.model.AC_000161.1.400 Q9GL50 STEA1_PIG 92.330 0.994118 1.00592 STEAP1 - Metalloreductase STEAP1 - Sus scrofa (Pig) - STEAP1 gene Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Taurus_UMD|evm.model.AC_000161.1.401 Q8NFT2 STEA2_HUMAN 97.551 0.995927 1.00204 STEAP2 - Metalloreductase STEAP2 - Homo sapiens (Human) - STEAP2 gene Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). Taurus_UMD|evm.model.AC_000161.1.402 B0CM26 CFA69_PAPAN 86.746 0.984076 1.00106 CFAP69 - Cilia- and flagella-associated protein 69 - Papio anubis (Olive baboon) - CFAP69 gene Cilium- and flagellum-associated protein (By similarity). In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability (By similarity). Taurus_UMD|evm.model.AC_000161.1.403 Q3MHG6 GTPBA_BOVIN 100.000 0.994845 1.00258 GTPBP10 - GTP-binding protein 10 - Bos taurus (Bovine) - GTPBP10 gene May be involved in the ribosome maturation process. Taurus_UMD|evm.model.AC_000161.1.404 O60921 HUS1_HUMAN 91.786 0.992883 1.00357 HUS1 - Checkpoint protein HUS1 - Homo sapiens (Human) - HUS1 gene Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Taurus_UMD|evm.model.AC_000161.1.406 Q68CZ2 TENS3_HUMAN 81.267 0.899749 1.1045 TNS3 - Tensin-3 - Homo sapiens (Human) - TNS3 gene May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity). Taurus_UMD|evm.model.AC_000161.1.407 O46415 FRIL_BOVIN 79.630 0.239819 1.26286 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000161.1.408 Q96MW7 TIGD1_HUMAN 33.415 0.909348 0.597293 TIGD1 - Tigger transposable element-derived protein 1 - Homo sapiens (Human) - TIGD1 gene nucleus, DNA binding Taurus_UMD|evm.model.AC_000161.1.409 Q8IVM0 CCD50_HUMAN 80.723 0.582734 0.454248 CCDC50 - Coiled-coil domain-containing protein 50 - Homo sapiens (Human) - CCDC50 gene Involved in EGFR signaling. Taurus_UMD|evm.model.AC_000161.1.410 P20959 IBP3_BOVIN 100.000 0.993151 1.00344 IGFBP3 - Insulin-like growth factor-binding protein 3 precursor - Bos taurus (Bovine) - IGFBP3 gene IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Taurus_UMD|evm.model.AC_000161.1.411 P24591 IBP1_BOVIN 100.000 0.992424 1.0038 IGFBP1 - Insulin-like growth factor-binding protein 1 precursor - Bos taurus (Bovine) - IGFBP1 gene IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity). Taurus_UMD|evm.model.AC_000161.1.413 P19754 ADCY1_BOVIN 100.000 0.968076 1.02205 ADCY1 - Adenylate cyclase type 1 - Bos taurus (Bovine) - ADCY1 gene Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:2472670, PubMed:2022671. PubMed:19029295). Mediates responses to increased cellular Ca(2+)/calmodulin levels (PubMed:2022671, PubMed:19029295). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). Taurus_UMD|evm.model.AC_000161.1.414 Q7YS88 RAMP3_PIG 81.208 0.980132 1 RAMP3 - Receptor activity-modifying protein 3 precursor - Sus scrofa (Pig) - RAMP3 gene Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity). Taurus_UMD|evm.model.AC_000161.1.415 Q3SZK4 FAKD4_BOVIN 98.798 0.858621 0.917722 TBRG4 - FAST kinase domain-containing protein 4 precursor - Bos taurus (Bovine) - TBRG4 gene Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression. Taurus_UMD|evm.model.AC_000161.1.416 Q6IP73 NACA_XENLA 72.222 0.0667496 11.3239 naca - Nascent polypeptide-associated complex subunit alpha - Xenopus laevis (African clawed frog) - naca gene May promote appropriate targeting of ribosome-nascent polypeptide complexes. Taurus_UMD|evm.model.AC_000161.1.417 Q9BSQ5 CCM2_HUMAN 90.337 0.930818 1.07432 CCM2 - Cerebral cavernous malformations 2 protein - Homo sapiens (Human) - CCM2 gene Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). Taurus_UMD|evm.model.AC_000161.1.418 B0I1T2 MYO1G_HUMAN 91.552 0.997041 0.996071 MYO1G - Unconventional myosin-Ig - Homo sapiens (Human) - MYO1G gene Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. Taurus_UMD|evm.model.AC_000161.1.419 Q96QR8 PURB_HUMAN 94.904 0.993443 0.977564 PURB - Transcriptional activator protein Pur-beta - Homo sapiens (Human) - PURB gene Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). Taurus_UMD|evm.model.AC_000161.1.420 Q5BJ65 H2AV_XENTR 100.000 0.984496 1.00781 h2az2 - Histone H2A.V - Xenopus tropicalis (Western clawed frog) - h2az2 gene Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). Taurus_UMD|evm.model.AC_000161.1.421 P62936 PPIA_PIG 100.000 0.987879 1.0061 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Taurus_UMD|evm.model.AC_000161.1.423 Q8NF64 ZMIZ2_HUMAN 88.203 0.997833 1.00326 ZMIZ2 - Zinc finger MIZ domain-containing protein 2 - Homo sapiens (Human) - ZMIZ2 gene Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors. Taurus_UMD|evm.model.AC_000161.1.426 Q148N0 ODO1_BOVIN 98.555 0.998075 1.01564 OGDH - 2-oxoglutarate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - OGDH gene 2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex (OGDHC), which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. Taurus_UMD|evm.model.AC_000161.1.427 Q7Z7H5 TMED4_HUMAN 95.833 0.990783 0.955947 TMED4 - Transmembrane emp24 domain-containing protein 4 precursor - Homo sapiens (Human) - TMED4 gene Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity). Taurus_UMD|evm.model.AC_000161.1.428 Q3SZ40 DDX56_BOVIN 100.000 0.996344 1.00183 DDX56 - Probable ATP-dependent RNA helicase DDX56 - Bos taurus (Bovine) - DDX56 gene May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (By similarity). Taurus_UMD|evm.model.AC_000161.1.429 Q9UHC9 NPCL1_HUMAN 80.088 0.998501 0.981604 NPC1L1 - NPC1-like intracellular cholesterol transporter 1 precursor - Homo sapiens (Human) - NPC1L1 gene Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation. Taurus_UMD|evm.model.AC_000161.1.430 Q5RB75 NUDC3_PONAB 87.912 0.994444 0.99723 NUDCD3 - NudC domain-containing protein 3 - Pongo abelii (Sumatran orangutan) - NUDCD3 gene Taurus_UMD|evm.model.AC_000161.1.431 Q9NSB8 HOME2_HUMAN 63.636 0.442177 0.415254 HOMER2 - Homer protein homolog 2 - Homo sapiens (Human) - HOMER2 gene Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). Taurus_UMD|evm.model.AC_000161.1.432 Q3MHJ9 KCC2B_BOVIN 99.513 0.634675 1.19188 CAMK2B - Calcium/calmodulin-dependent protein kinase type II subunit beta - Bos taurus (Bovine) - CAMK2B gene Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. Taurus_UMD|evm.model.AC_000161.1.434 Q3T000 YKT6_BOVIN 100.000 0.98995 1.00505 YKT6 - Synaptobrevin homolog YKT6 precursor - Bos taurus (Bovine) - YKT6 gene Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. Taurus_UMD|evm.model.AC_000161.1.435 P35557 HXK4_HUMAN 96.659 0.963441 1 GCK - Hexokinase-4 - Homo sapiens (Human) - GCK gene Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively) (PubMed:7742312, PubMed:11916951, PubMed:15277402, PubMed:17082186, PubMed:18322640, PubMed:19146401, PubMed:25015100, PubMed:8325892). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues (PubMed:18322640, PubMed:25015100, PubMed:8325892, PubMed:11916951, PubMed:15277402). Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change its enzymatic activity within the physiological range of glucose concentrations, GCK acts as a glucose sensor in the pancreatic beta cell (By similarity). In pancreas, plays an important role in modulating insulin secretion (By similarity). In liver, helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (By similarity). Required to provide D-glucose 6-phosphate for the synthesis of glycogen (PubMed:8878425). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:7742312). Taurus_UMD|evm.model.AC_000161.1.436 F1SSF9 MLRA_PIG 98.286 0.988636 1.00571 MYL7 - Myosin regulatory light chain 2, atrial isoform - Sus scrofa (Pig) - MYL7 gene Taurus_UMD|evm.model.AC_000161.1.437 P49004 DPOD2_BOVIN 100.000 0.995745 1.00213 POLD2 - DNA polymerase delta subunit 2 - Bos taurus (Bovine) - POLD2 gene Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7. Taurus_UMD|evm.model.AC_000161.1.438 Q8IUX7 AEBP1_HUMAN 83.251 0.838654 1.00086 AEBP1 - Adipocyte enhancer-binding protein 1 precursor - Homo sapiens (Human) - AEBP1 gene As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix. Taurus_UMD|evm.model.AC_000161.1.439 Q9NP87 DPOLM_HUMAN 82.057 0.995604 0.921053 POLM - DNA-directed DNA/RNA polymerase mu - Homo sapiens (Human) - POLM gene Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. Taurus_UMD|evm.model.AC_000161.1.440 P53004 BIEA_HUMAN 92.230 0.993266 1.00338 BLVRA - Biliverdin reductase A precursor - Homo sapiens (Human) - BLVRA gene Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Taurus_UMD|evm.model.AC_000161.1.442 Q9GZY4 COA1_HUMAN 71.111 0.977941 0.931507 COA1 - Cytochrome c oxidase assembly factor 1 homolog - Homo sapiens (Human) - COA1 gene Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV. Taurus_UMD|evm.model.AC_000161.1.443 Q9UEE5 ST17A_HUMAN 88.000 0.951389 0.695652 STK17A - Serine/threonine-protein kinase 17A - Homo sapiens (Human) - STK17A gene Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. Taurus_UMD|evm.model.AC_000161.1.444 Q9UEE5 ST17A_HUMAN 89.928 0.985714 0.338164 STK17A - Serine/threonine-protein kinase 17A - Homo sapiens (Human) - STK17A gene Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. Taurus_UMD|evm.model.AC_000161.1.445 Q76N89 HECW1_HUMAN 79.548 0.998974 0.607098 HECW1 - E3 ubiquitin-protein ligase HECW1 - Homo sapiens (Human) - HECW1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. Taurus_UMD|evm.model.AC_000161.1.446 Q2TBI6 RM32_BOVIN 100.000 0.989418 1.00532 MRPL32 - 39S ribosomal protein L32, mitochondrial precursor - Bos taurus (Bovine) - MRPL32 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000161.1.447 P25787 PSA2_HUMAN 100.000 0.991489 1.00427 PSMA2 - Proteasome subunit alpha type-2 - Homo sapiens (Human) - PSMA2 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Taurus_UMD|evm.model.AC_000161.1.449 Q1LZE8 CG025_BOVIN 100.000 0.995261 1.00238 UPF0415 protein C7orf25 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000161.1.450 A6H767 NP1L1_BOVIN 96.491 0.174455 0.820972 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Taurus_UMD|evm.model.AC_000161.1.451 Q5IS56 GLI3_PANTR 88.239 0.998741 1.00506 GLI3 - Transcriptional activator GLI3 - Pan troglodytes (Chimpanzee) - GLI3 gene Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. Plays a role in limb and brain development (By similarity). Taurus_UMD|evm.model.AC_000161.1.453 P07995 INHBA_BOVIN 100.000 0.995305 1.00235 INHBA - Inhibin beta A chain precursor - Bos taurus (Bovine) - INHBA gene Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Taurus_UMD|evm.model.AC_000161.1.455 Q9HAC7 SUCHY_HUMAN 91.781 0.947368 0.170787 SUGCT - Succinate--hydroxymethylglutarate CoA-transferase precursor - Homo sapiens (Human) - SUGCT gene Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate. Taurus_UMD|evm.model.AC_000161.1.456 P54792 DVLP1_HUMAN 88.710 0.7625 0.119403 DVL1P1 - Putative segment polarity protein dishevelled homolog DVL1P1 - Homo sapiens (Human) - DVL1P1 gene May play a role in the signal transduction pathway mediated by multiple Wnt genes. Taurus_UMD|evm.model.AC_000161.1.457 Q9HAC7 SUCHY_HUMAN 91.758 0.989101 0.824719 SUGCT - Succinate--hydroxymethylglutarate CoA-transferase precursor - Homo sapiens (Human) - SUGCT gene Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate. Taurus_UMD|evm.model.AC_000161.1.458 Q8TAP9 MPLKI_HUMAN 94.413 0.988889 1.00559 MPLKIP - M-phase-specific PLK1-interacting protein - Homo sapiens (Human) - MPLKIP gene May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. Taurus_UMD|evm.model.AC_000161.1.459 E1BB52 CDK13_BOVIN 100.000 0.741913 0.960979 CDK13 - Cyclin-dependent kinase 13 - Bos taurus (Bovine) - CDK13 gene Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis (By similarity). Taurus_UMD|evm.model.AC_000161.1.460 Q3ZBG0 PSA7_BOVIN 82.432 0.888889 0.326613 PSMA7 - Proteasome subunit alpha type-7 - Bos taurus (Bovine) - PSMA7 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. Taurus_UMD|evm.model.AC_000161.1.461 P63320 RALA_SAGOE 99.515 0.990338 1.00485 RALA - Ras-related protein Ral-A precursor - Saguinus oedipus (Cotton-top tamarin) - RALA gene Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody. During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (By similarity). Taurus_UMD|evm.model.AC_000161.1.462 Q9NRH1 YAE1_HUMAN 83.186 0.991189 1.00442 YAE1 - Protein YAE1 homolog - Homo sapiens (Human) - YAE1 gene The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:26182403). Taurus_UMD|evm.model.AC_000161.1.463 P78424 PO6F2_HUMAN 98.857 0.806005 0.626628 POU6F2 - POU domain, class 6, transcription factor 2 - Homo sapiens (Human) - POU6F2 gene Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA. Taurus_UMD|evm.model.AC_000161.1.464 P49754 VPS41_HUMAN 97.658 0.997661 1.00117 VPS41 - Vacuolar protein sorting-associated protein 41 homolog - Homo sapiens (Human) - VPS41 gene Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes (PubMed:25783203). Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:25445562, PubMed:25908847, PubMed:21802320). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660). Taurus_UMD|evm.model.AC_000161.1.466 P49418 AMPH_HUMAN 88.218 0.99708 0.985612 AMPH - Amphiphysin - Homo sapiens (Human) - AMPH gene May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. Taurus_UMD|evm.model.AC_000161.1.467 A0A0A0MS01 TVG10_HUMAN 64.211 0.978723 0.789916 TRGV10 - Probable non-functional T cell receptor gamma variable 10 precursor - Homo sapiens (Human) - TRGV10 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) gamma chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000161.1.468 P06324 TVC3_MOUSE 54.808 0.261421 2.98485 T-cell receptor gamma chain V region DFL12 precursor - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000161.1.469 A0A0A0MS01 TVG10_HUMAN 64.167 0.609375 1.61345 TRGV10 - Probable non-functional T cell receptor gamma variable 10 precursor - Homo sapiens (Human) - TRGV10 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) gamma chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000161.1.470 A5PK65 DOPD_BOVIN 92.958 0.972222 0.610169 DDT - D-dopachrome decarboxylase - Bos taurus (Bovine) - DDT gene Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Taurus_UMD|evm.model.AC_000161.1.471 P01853 TCC1_MOUSE 59.184 0.960396 0.60479 T-cell receptor gamma chain C region C10.5 - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000161.1.472 A0A0C4DH27 TRGV8_HUMAN 54.902 0.604938 1.37288 TRGV8 - T cell receptor gamma variable 8 precursor - Homo sapiens (Human) - TRGV8 gene V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000161.1.473 A0A0C4DH27 TRGV8_HUMAN 57.282 0.634615 1.32203 TRGV8 - T cell receptor gamma variable 8 precursor - Homo sapiens (Human) - TRGV8 gene V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000161.1.474 A0A0C4DH27 TRGV8_HUMAN 51.546 0.661654 1.12712 TRGV8 - T cell receptor gamma variable 8 precursor - Homo sapiens (Human) - TRGV8 gene V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000161.1.475 P0CF51 TRGC1_HUMAN 67.568 0.172249 1.20809 TRGC1 - T cell receptor gamma constant 1 - Homo sapiens (Human) - TRGC1 gene Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000161.1.476 A0A0C4DH27 TRGV8_HUMAN 60.194 0.610778 1.41525 TRGV8 - T cell receptor gamma variable 8 precursor - Homo sapiens (Human) - TRGV8 gene V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000161.1.477 A0A0C4DH27 TRGV8_HUMAN 60.194 0.610778 1.41525 TRGV8 - T cell receptor gamma variable 8 precursor - Homo sapiens (Human) - TRGV8 gene V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000161.1.478 A0A0C4DH27 TRGV8_HUMAN 60.194 0.303571 2.84746 TRGV8 - T cell receptor gamma variable 8 precursor - Homo sapiens (Human) - TRGV8 gene V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000161.1.479 P03986 TRGC2_HUMAN 55.924 0.568681 1.92593 TRGC2 - T cell receptor gamma constant 2 - Homo sapiens (Human) - TRGC2 gene Constant region of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000161.1.480 Q5RCP3 LSM8_PONAB 71.642 0.985185 1.40625 LSM8 - U6 snRNA-associated Sm-like protein LSm8 - Pongo abelii (Sumatran orangutan) - LSM8 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Taurus_UMD|evm.model.AC_000161.1.481 Q9ULM0 PKHH1_HUMAN 67.581 0.994667 0.274927 PLEKHH1 - Pleckstrin homology domain-containing family H member 1 - Homo sapiens (Human) - PLEKHH1 gene Taurus_UMD|evm.model.AC_000161.1.482 Q5RA31 TOM20_PONAB 97.931 0.986301 1.0069 TOMM20 - Mitochondrial import receptor subunit TOM20 homolog - Pongo abelii (Sumatran orangutan) - TOMM20 gene Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. Taurus_UMD|evm.model.AC_000161.1.483 O77834 PRDX6_BOVIN 85.714 0.990385 0.928571 PRDX6 - Peroxiredoxin-6 - Bos taurus (Bovine) - PRDX6 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10409692, PubMed:2373154). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10409692). Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10409692, PubMed:2373154, PubMed:9787801). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity). Taurus_UMD|evm.model.AC_000161.1.485 Q9NZV8 KCND2_HUMAN 98.824 0.992188 0.406349 KCND2 - Potassium voltage-gated channel subfamily D member 2 - Homo sapiens (Human) - KCND2 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:15454437, PubMed:14695263, PubMed:14623880, PubMed:14980201, PubMed:16934482, PubMed:24811166, PubMed:24501278). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:15454437, PubMed:14623880, PubMed:14980201, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity). Taurus_UMD|evm.model.AC_000161.1.486 Q29RH7 TSN12_BOVIN 83.934 0.992218 0.842623 TSPAN12 - Tetraspanin-12 - Bos taurus (Bovine) - TSPAN12 gene Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity). Taurus_UMD|evm.model.AC_000161.1.488 Q9NXR8 ING3_HUMAN 98.086 0.995227 1.00239 ING3 - Inhibitor of growth protein 3 - Homo sapiens (Human) - ING3 gene Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Taurus_UMD|evm.model.AC_000161.1.489 A4D0V7 CPED1_HUMAN 78.394 0.977077 0.680312 CPED1 - Cadherin-like and PC-esterase domain-containing protein 1 precursor - Homo sapiens (Human) - CPED1 gene endoplasmic reticulum Taurus_UMD|evm.model.AC_000161.1.490 Q5E9U6 WNT16_BOVIN 99.724 0.99449 1.00276 WNT16 - Protein Wnt-16 precursor - Bos taurus (Bovine) - WNT16 gene Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Taurus_UMD|evm.model.AC_000161.1.491 A5PKI3 FAM3C_BOVIN 100.000 0.991228 1.00441 FAM3C - Protein FAM3C precursor - Bos taurus (Bovine) - FAM3C gene May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition (By similarity). Taurus_UMD|evm.model.AC_000161.1.494 P23471 PTPRZ_HUMAN 84.457 0.999137 1.00086 PTPRZ1 - Receptor-type tyrosine-protein phosphatase zeta precursor - Homo sapiens (Human) - PTPRZ1 gene Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity). Taurus_UMD|evm.model.AC_000161.1.495 A8E657 AASS_BOVIN 98.272 0.997814 0.988121 AASS - Alpha-aminoadipic semialdehyde synthase, mitochondrial precursor - Bos taurus (Bovine) - AASS gene Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-oxoglutarate reductase and saccharopine dehydrogenase activity, respectively (By similarity). Taurus_UMD|evm.model.AC_000161.1.496 Q5R6X7 CBX3_PONAB 79.191 0.9875 0.874317 CBX3 - Chromobox protein homolog 3 - Pongo abelii (Sumatran orangutan) - CBX3 gene Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs). Taurus_UMD|evm.model.AC_000161.1.498 O02751 CFDP2_BOVIN 78.626 0.270833 0.810811 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000161.1.499 A0PJY2 FEZF1_HUMAN 93.694 0.82037 1.13684 FEZF1 - Fez family zinc finger protein 1 - Homo sapiens (Human) - FEZF1 gene Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity). Taurus_UMD|evm.model.AC_000161.1.500 Q86UW7 CAPS2_HUMAN 93.601 0.998401 0.965278 CADPS2 - Calcium-dependent secretion activator 2 - Homo sapiens (Human) - CADPS2 gene Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). Taurus_UMD|evm.model.AC_000161.1.501 Q646B3 T2R16_PANTR 57.627 0.97351 1.0378 TAS2R16 - Taste receptor type 2 member 16 - Pan troglodytes (Chimpanzee) - TAS2R16 gene Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Taurus_UMD|evm.model.AC_000161.1.502 Q9BZW2 S13A1_HUMAN 87.940 0.996656 1.00504 SLC13A1 - Solute carrier family 13 member 1 - Homo sapiens (Human) - SLC13A1 gene Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney. Taurus_UMD|evm.model.AC_000161.1.503 Q8NA54 IQUB_HUMAN 67.758 0.994624 0.940582 IQUB - IQ and ubiquitin-like domain-containing protein - Homo sapiens (Human) - IQUB gene May play roles in cilia formation and/or maintenance. Taurus_UMD|evm.model.AC_000161.1.504 P23935 NDUA5_BOVIN 100.000 0.982906 1.00862 NDUFA5 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 - Bos taurus (Bovine) - NDUFA5 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000161.1.505 Q8HXA6 ASB15_BOVIN 100.000 0.996604 1.0017 ASB15 - Ankyrin repeat and SOCS box protein 15 - Bos taurus (Bovine) - ASB15 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000161.1.506 Q6P5Q4 LMOD2_HUMAN 84.335 0.996198 0.961609 LMOD2 - Leiomodin-2 - Homo sapiens (Human) - LMOD2 gene Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:26370058, PubMed:25250574, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713). Taurus_UMD|evm.model.AC_000161.1.507 Q95107 WASL_BOVIN 100.000 0.996047 1.00198 WASL - Neural Wiskott-Aldrich syndrome protein - Bos taurus (Bovine) - WASL gene Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:17609109). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity). Taurus_UMD|evm.model.AC_000161.1.508 Q2M3T9 HYAL4_HUMAN 86.829 0.992718 0.856549 HYAL4 - Hyaluronidase-4 - Homo sapiens (Human) - HYAL4 gene Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide. Taurus_UMD|evm.model.AC_000161.1.509 P38568 HYALP_MACFA 62.924 0.850181 1.08627 SPAM1 - Hyaluronidase PH-20 precursor - Macaca fascicularis (Crab-eating macaque) - SPAM1 gene Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. Taurus_UMD|evm.model.AC_000161.1.510 Q95107 WASL_BOVIN 83.333 0.471264 0.172277 WASL - Neural Wiskott-Aldrich syndrome protein - Bos taurus (Bovine) - WASL gene Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:17609109). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity). Taurus_UMD|evm.model.AC_000161.1.511 A3QVN9 HYAL1_BITAR 48.936 0.882353 1.06013 Hyaluronidase-1 precursor - Bitis arietans (African puff adder) Taurus_UMD|evm.model.AC_000161.1.512 P38568 HYALP_MACFA 65.594 0.82377 0.956863 SPAM1 - Hyaluronidase PH-20 precursor - Macaca fascicularis (Crab-eating macaque) - SPAM1 gene Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. Taurus_UMD|evm.model.AC_000161.1.513 P15927 RFA2_HUMAN 89.423 0.980952 0.388889 RPA2 - Replication protein A 32 kDa subunit - Homo sapiens (Human) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Taurus_UMD|evm.model.AC_000161.1.514 Q5RC43 RFA2_PONAB 89.189 0.301848 1.8037 RPA2 - Replication protein A 32 kDa subunit - Pongo abelii (Sumatran orangutan) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Taurus_UMD|evm.model.AC_000161.1.515 P18621 RL17_HUMAN 78.125 0.588785 0.581522 RPL17 - 60S ribosomal protein L17 - Homo sapiens (Human) - RPL17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000161.1.516 O15354 GPR37_HUMAN 88.436 0.996743 1.00163 GPR37 - Prosaposin receptor GPR37 precursor - Homo sapiens (Human) - GPR37 gene Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. Taurus_UMD|evm.model.AC_000161.1.517 Q9NUX5 POTE1_HUMAN 85.893 0.810433 1.23975 POT1 - Protection of telomeres protein 1 - Homo sapiens (Human) - POT1 gene Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Taurus_UMD|evm.model.AC_000161.1.518 P32233 DRG1_MOUSE 50.870 0.970443 0.553134 Drg1 - Developmentally-regulated GTP-binding protein 1 - Mus musculus (Mouse) - Drg1 gene Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions. Taurus_UMD|evm.model.AC_000161.1.520 A2Q0Z0 EF1A1_HORSE 64.829 0.95356 0.699134 EEF1A1 - Elongation factor 1-alpha 1 - Equus caballus (Horse) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000161.1.521 Q8R088 GLP3L_MOUSE 82.000 0.803279 0.214035 Golph3l - Golgi phosphoprotein 3-like - Mus musculus (Mouse) - Golph3l gene Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. Taurus_UMD|evm.model.AC_000161.1.523 Q2TB10 ZN800_HUMAN 97.892 0.911967 1.09488 ZNF800 - Zinc finger protein 800 - Homo sapiens (Human) - ZNF800 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000161.1.524 Q96CN9 GCC1_HUMAN 92.903 0.997423 1.00129 GCC1 - GRIP and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - GCC1 gene Probably involved in maintaining Golgi structure. Taurus_UMD|evm.model.AC_000161.1.525 P84083 ARF5_RAT 100.000 0.98895 1.00556 Arf5 - ADP-ribosylation factor 5 - Rattus norvegicus (Rat) - Arf5 gene GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Taurus_UMD|evm.model.AC_000161.1.526 Q9NQT6 FSCN3_HUMAN 83.133 0.995992 1.00201 FSCN3 - Fascin-3 - Homo sapiens (Human) - FSCN3 gene Acts as an actin bundling protein. Taurus_UMD|evm.model.AC_000161.1.527 O43316 PAX4_HUMAN 88.017 0.919847 0.748571 PAX4 - Paired box protein Pax-4 - Homo sapiens (Human) - PAX4 gene Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity. Taurus_UMD|evm.model.AC_000161.1.528 Q863B3 SND1_BOVIN 100.000 0.962649 0.647253 SND1 - Staphylococcal nuclease domain-containing protein 1 - Bos taurus (Bovine) - SND1 gene Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (By similarity). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (By similarity). Functions as a bridging factor between STAT6 and the basal transcription factor (By similarity). Plays a role in PIM1 regulation of MYB activity (By similarity). Functions as a transcriptional coactivator for STAT5 (By similarity). Taurus_UMD|evm.model.AC_000161.1.529 Q9HBW1 LRRC4_HUMAN 98.162 0.996937 1 LRRC4 - Leucine-rich repeat-containing protein 4 precursor - Homo sapiens (Human) - LRRC4 gene Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity). Taurus_UMD|evm.model.AC_000161.1.531 Q863B3 SND1_BOVIN 100.000 0.9875 0.351648 SND1 - Staphylococcal nuclease domain-containing protein 1 - Bos taurus (Bovine) - SND1 gene Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (By similarity). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (By similarity). Functions as a bridging factor between STAT6 and the basal transcription factor (By similarity). Plays a role in PIM1 regulation of MYB activity (By similarity). Functions as a transcriptional coactivator for STAT5 (By similarity). Taurus_UMD|evm.model.AC_000161.1.533 P50595 LEP_BOVIN 99.401 0.988095 1.00599 LEP - Leptin precursor - Bos taurus (Bovine) - LEP gene Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (By similarity). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (By similarity). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (By similarity). Taurus_UMD|evm.model.AC_000161.1.534 Q9NW13 RBM28_HUMAN 84.363 0.99734 0.990777 RBM28 - RNA-binding protein 28 - Homo sapiens (Human) - RBM28 gene Nucleolar component of the spliceosomal ribonucleoprotein complexes. Taurus_UMD|evm.model.AC_000161.1.535 C9JH25 PRRT4_HUMAN 91.317 0.456996 0.866518 PRRT4 - Proline-rich transmembrane protein 4 precursor - Homo sapiens (Human) - PRRT4 gene Taurus_UMD|evm.model.AC_000161.1.536 Q5PPS7 TM53A_XENLA 25.506 0.846715 0.961404 tmem53-a - Transmembrane protein 53-A - Xenopus laevis (African clawed frog) - tmem53-a gene Taurus_UMD|evm.model.AC_000161.1.537 A0JNA3 IMDH1_BOVIN 100.000 0.896853 1.11284 IMPDH1 - Inosine-5'-monophosphate dehydrogenase 1 - Bos taurus (Bovine) - IMPDH1 gene Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Taurus_UMD|evm.model.AC_000161.1.538 Q6NXP2 F71F2_HUMAN 72.903 0.990033 0.97411 FAM71F2 - Protein FAM71F2 - Homo sapiens (Human) - FAM71F2 gene Taurus_UMD|evm.model.AC_000161.1.539 Q2KIP3 F71F1_BOVIN 99.420 0.994186 0.997101 FAM71F1 - Protein FAM71F1 - Bos taurus (Bovine) - FAM71F1 gene Taurus_UMD|evm.model.AC_000161.1.540 Q3T0K1 CALU_BOVIN 77.165 0.824295 1.46349 CALU - Calumenin precursor - Bos taurus (Bovine) - CALU gene Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). Taurus_UMD|evm.model.AC_000161.1.541 P51490 OPSB_BOVIN 100.000 0.994286 1.00287 OPN1SW - Short-wave-sensitive opsin 1 - Bos taurus (Bovine) - OPN1SW gene Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (By similarity). Involved in ensuring correct abundance and localization of retinal membrane proteins (By similarity). May increase spectral sensitivity in dim light (By similarity). Taurus_UMD|evm.model.AC_000161.1.542 Q96JN2 CC136_HUMAN 73.864 0.942739 1.04419 CCDC136 - Coiled-coil domain-containing protein 136 - Homo sapiens (Human) - CCDC136 gene May play a role in acrosome formation in spermatogenesis and in fertilization. Taurus_UMD|evm.model.AC_000161.1.543 Q14315 FLNC_HUMAN 98.386 0.999265 0.998532 FLNC - Filamin-C - Homo sapiens (Human) - FLNC gene Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. Taurus_UMD|evm.model.AC_000161.1.544 Q28029 VATF_BOVIN 100.000 0.983333 1.0084 ATP6V1F - V-type proton ATPase subunit F - Bos taurus (Bovine) - ATP6V1F gene Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Taurus_UMD|evm.model.AC_000161.1.545 A0A1B0GUX0 VAFNB_HUMAN 86.932 0.988701 1.00568 ATP6V1FNB - Protein ATP6V1FNB - Homo sapiens (Human) - ATP6V1FNB gene Taurus_UMD|evm.model.AC_000161.1.547 Q6ZWJ8 KCP_HUMAN 74.496 0.726036 1.07781 KCP - Kielin/chordin-like protein precursor - Homo sapiens (Human) - KCP gene Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity). Taurus_UMD|evm.model.AC_000161.1.548 Q58DJ0 IRF5_BOVIN 99.399 0.894075 1.11623 IRF5 - Interferon regulatory factor 5 - Bos taurus (Bovine) - IRF5 gene Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway. Taurus_UMD|evm.model.AC_000161.1.549 Q9Y5L0 TNPO3_HUMAN 99.133 0.997835 1.00108 TNPO3 - Transportin-3 - Homo sapiens (Human) - TNPO3 gene Importin, which transports target proteins into the nucleus (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation (PubMed:30916345, PubMed:31465518). The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively (PubMed:23878195, PubMed:24449914). Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus (PubMed:23878195, PubMed:24449914). Taurus_UMD|evm.model.AC_000161.1.550 Q3SYV5 TSN33_BOVIN 99.647 0.992958 1.00353 TSPAN33 - Tetraspanin-33 - Bos taurus (Bovine) - TSPAN33 gene Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (By similarity). Taurus_UMD|evm.model.AC_000161.1.551 Q99835 SMO_HUMAN 94.437 0.997439 0.992376 SMO - Smoothened homolog precursor - Homo sapiens (Human) - SMO gene G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). Taurus_UMD|evm.model.AC_000161.1.552 A6QLP2 SAHH3_BOVIN 99.836 0.996727 1 AHCYL2 - Adenosylhomocysteinase 3 - Bos taurus (Bovine) - AHCYL2 gene May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (By similarity). Taurus_UMD|evm.model.AC_000161.1.553 Q9ULQ0 STRP2_HUMAN 97.482 0.997605 1.0012 STRIP2 - Striatin-interacting protein 2 - Homo sapiens (Human) - STRIP2 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Taurus_UMD|evm.model.AC_000161.1.554 Q62792 NRF1_RAT 100.000 0.10119 9.69231 Nrf1 - Nuclear respiratory factor 1 - Rattus norvegicus (Rat) - Nrf1 gene Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication (By similarity). Taurus_UMD|evm.model.AC_000161.1.555 Q00361 ATP5I_BOVIN 95.775 0.972222 1.01408 ATP5ME - ATP synthase subunit e, mitochondrial - Bos taurus (Bovine) - ATP5ME gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Taurus_UMD|evm.model.AC_000161.1.556 P62257 UBE2H_MOUSE 83.060 0.986928 0.836066 Ube2h - Ubiquitin-conjugating enzyme E2 H - Mus musculus (Mouse) - Ube2h gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A. Taurus_UMD|evm.model.AC_000161.1.557 Q86WB0 NIPA_HUMAN 89.022 0.99389 0.978088 ZC3HC1 - Nuclear-interacting partner of ALK - Homo sapiens (Human) - ZC3HC1 gene Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. Taurus_UMD|evm.model.AC_000161.1.558 Q0IIC2 KLD10_BOVIN 100.000 0.995485 1.00226 KLHDC10 - Kelch domain-containing protein 10 - Bos taurus (Bovine) - KLHDC10 gene Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5 (By similarity). Taurus_UMD|evm.model.AC_000161.1.559 Q96SK2 TM209_HUMAN 96.786 0.960481 1.03743 TMEM209 - Transmembrane protein 209 - Homo sapiens (Human) - TMEM209 gene Taurus_UMD|evm.model.AC_000161.1.560 Q4R309 SSMM1_MACFA 75.000 0.991736 0.991803 SSMEM1 - Serine-rich single-pass membrane protein 1 - Macaca fascicularis (Crab-eating macaque) - SSMEM1 gene Taurus_UMD|evm.model.AC_000161.1.561 Q9UI42 CBPA4_HUMAN 71.667 0.943694 1.05463 CPA4 - Carboxypeptidase A4 precursor - Homo sapiens (Human) - CPA4 gene Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164). Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563). Taurus_UMD|evm.model.AC_000161.1.562 Q8WXQ8 CBPA5_HUMAN 88.599 0.961098 1.00229 CPA5 - Carboxypeptidase A5 precursor - Homo sapiens (Human) - CPA5 gene extracellular space, metallocarboxypeptidase activity, proteolysis Taurus_UMD|evm.model.AC_000161.1.563 P00730 CBPA1_BOVIN 99.761 0.995238 1.00239 CPA1 - Carboxypeptidase A1 precursor - Bos taurus (Bovine) - CPA1 gene Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity). Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (PubMed:12729612). Taurus_UMD|evm.model.AC_000161.1.564 F1MUG2 CEP41_BOVIN 100.000 0.994652 1.00268 CEP41 - Centrosomal protein of 41 kDa - Bos taurus (Bovine) - CEP41 gene Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium (By similarity). Taurus_UMD|evm.model.AC_000161.1.565 P08548 LIN1_NYCCO 30.323 0.943038 0.125397 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Taurus_UMD|evm.model.AC_000161.1.566 Q10126 YSM6_CAEEL 29.375 0.508961 1 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000161.1.568 Q2HJM9 MEST_BOVIN 99.701 0.994048 1.00299 MEST - Mesoderm-specific transcript homolog protein - Bos taurus (Bovine) - MEST gene endoplasmic reticulum Taurus_UMD|evm.model.AC_000161.1.569 Q9QXK3 COPG2_MOUSE 94.937 0.110953 0.807118 Copg2 - Coatomer subunit gamma-2 - Mus musculus (Mouse) - Copg2 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Taurus_UMD|evm.model.AC_000161.1.570 Q3T028 TSG13_BOVIN 100.000 0.992674 1.00368 TSGA13 - Testis-specific gene 13 protein - Bos taurus (Bovine) - TSGA13 gene Taurus_UMD|evm.model.AC_000161.1.571 Q19A40 KLF14_PANTR 88.652 0.737968 0.578947 KLF14 - Krueppel-like factor 14 - Pan troglodytes (Chimpanzee) - KLF14 gene DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000161.1.573 Q5RB35 MKLN1_PONAB 99.573 0.988717 0.964626 MKLN1 - Muskelin - Pongo abelii (Sumatran orangutan) - MKLN1 gene Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity). Taurus_UMD|evm.model.AC_000161.1.574 Q52S86 PODXL_CANLF 66.667 0.425795 0.991243 PODXL - Podocalyxin precursor - Canis lupus familiaris (Dog) - PODXL gene Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. Taurus_UMD|evm.model.AC_000161.1.575 Q8HXE3 KMCP1_MACFA 84.545 0.521951 0.704467 SLC25A30 - Kidney mitochondrial carrier protein 1 - Macaca fascicularis (Crab-eating macaque) - SLC25A30 gene Probable transporter. Taurus_UMD|evm.model.AC_000161.1.577 Q9HCM2 PLXA4_HUMAN 97.853 0.891291 0.854805 PLXNA4 - Plexin-A4 precursor - Homo sapiens (Human) - PLXNA4 gene Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). Taurus_UMD|evm.model.AC_000161.1.578 Q8NGH9 O52E4_HUMAN 64.126 0.991071 0.717949 OR52E4 - Olfactory receptor 52E4 - Homo sapiens (Human) - OR52E4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000161.1.579 Q9H2C5 O52A5_HUMAN 60.547 0.972763 0.813291 OR52A5 - Olfactory receptor 52A5 - Homo sapiens (Human) - OR52A5 gene Odorant receptor. Taurus_UMD|evm.model.AC_000161.1.580 Q80UG2 PLXA4_MOUSE 96.711 0.732689 0.328051 Plxna4 - Plexin-A4 precursor - Mus musculus (Mouse) - Plxna4 gene Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Taurus_UMD|evm.model.AC_000161.1.581 Q5E9D3 MIC19_BOVIN 100.000 0.991228 1.00441 CHCHD3 - MICOS complex subunit MIC19 - Bos taurus (Bovine) - CHCHD3 gene Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. Taurus_UMD|evm.model.AC_000161.1.582 Q96A65 EXOC4_HUMAN 97.006 0.996016 0.5154 EXOC4 - Exocyst complex component 4 - Homo sapiens (Human) - EXOC4 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Taurus_UMD|evm.model.AC_000161.1.583 Q96M69 LRGUK_HUMAN 75.843 0.95974 0.933333 LRGUK - Leucine-rich repeat and guanylate kinase domain-containing protein - Homo sapiens (Human) - LRGUK gene Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. Taurus_UMD|evm.model.AC_000161.1.584 Q95KB4 S35B4_MACFA 94.260 0.993976 1.00302 SLC35B4 - UDP-xylose and UDP-N-acetylglucosamine transporter - Macaca fascicularis (Crab-eating macaque) - SLC35B4 gene Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi. Taurus_UMD|evm.model.AC_000161.1.585 P16116 ALDR_BOVIN 99.365 0.990536 1.00635 AKR1B1 - Aldo-keto reductase family 1 member B1 - Bos taurus (Bovine) - AKR1B1 gene Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Taurus_UMD|evm.model.AC_000161.1.586 O60218 AK1BA_HUMAN 78.481 0.993569 0.984177 AKR1B10 - Aldo-keto reductase family 1 member B10 - Homo sapiens (Human) - AKR1B10 gene Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:9565553, PubMed:18087047, PubMed:12732097, PubMed:19013440, PubMed:19563777). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097). Taurus_UMD|evm.model.AC_000161.1.587 Q3T014 PMGE_BOVIN 99.614 0.877551 1.13514 BPGM - Bisphosphoglycerate mutase - Bos taurus (Bovine) - BPGM gene Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. Taurus_UMD|evm.model.AC_000161.1.588 Q27976 CALD1_BOVIN 95.312 0.0797468 9.51807 CALD1 - Non-muscle caldesmon - Bos taurus (Bovine) - CALD1 gene Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Taurus_UMD|evm.model.AC_000161.1.589 E1B9D8 CBPC3_BOVIN 94.821 0.997932 0.964108 AGBL3 - Cytosolic carboxypeptidase 3 - Bos taurus (Bovine) - AGBL3 gene Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates or polyaspartates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin. Taurus_UMD|evm.model.AC_000161.1.590 Q9NV12 TM140_HUMAN 71.023 0.925926 1.02162 TMEM140 - Transmembrane protein 140 - Homo sapiens (Human) - TMEM140 gene Taurus_UMD|evm.model.AC_000161.1.591 Q9BWK5 CYREN_HUMAN 62.346 0.987013 0.980892 CYREN - Cell cycle regulator of non-homologous end joining - Homo sapiens (Human) - CYREN gene Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S and G2 phases (PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70, interaction restricted during the S and G2 phases only (PubMed:28959974). Molecular mechanisms governing classical NHEJ inhibition via interaction with XRCC5/Ku80 and XRCC6/Ku70 are unknown (PubMed:28959974). May act as a regulator of proteasome (By similarity). Taurus_UMD|evm.model.AC_000161.1.593 Q2HJE1 WDR91_BOVIN 96.247 0.997234 0.969169 WDR91 - WD repeat-containing protein 91 - Bos taurus (Bovine) - WDR91 gene Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May play a role in meiosis. Taurus_UMD|evm.model.AC_000161.1.594 Q7Z7C7 STRA8_HUMAN 73.913 0.322946 1.0697 STRA8 - Stimulated by retinoic acid gene 8 protein homolog - Homo sapiens (Human) - STRA8 gene Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis. Taurus_UMD|evm.model.AC_000161.1.595 Q9EPR4 S23A2_MOUSE 52.390 0.826484 1.01389 Slc23a2 - Solute carrier family 23 member 2 - Mus musculus (Mouse) - Slc23a2 gene Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (By similarity). Taurus_UMD|evm.model.AC_000161.1.596 Q9EPR4 S23A2_MOUSE 52.757 0.890164 0.941358 Slc23a2 - Solute carrier family 23 member 2 - Mus musculus (Mouse) - Slc23a2 gene Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (By similarity). Taurus_UMD|evm.model.AC_000161.1.597 O95628 CNOT4_HUMAN 98.711 0.842187 1.11304 CNOT4 - CCR4-NOT transcription complex subunit 4 - Homo sapiens (Human) - CNOT4 gene Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038). Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292). Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391). Taurus_UMD|evm.model.AC_000161.1.598 Q92621 NU205_HUMAN 96.272 0.964046 1.03678 NUP205 - Nuclear pore complex protein Nup205 - Homo sapiens (Human) - NUP205 gene Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). Taurus_UMD|evm.model.AC_000161.1.599 P61314 RL15_RAT 99.510 0.990244 1.0049 Rpl15 - 60S ribosomal protein L15 - Rattus norvegicus (Rat) - Rpl15 gene A band, cytosolic large ribosomal subunit, nucleus, RNA binding, structural constituent of ribosome, cytoplasmic translation, response to ethanol Taurus_UMD|evm.model.AC_000161.1.600 Q9UKG4 S13A4_HUMAN 90.940 0.849785 1.11661 SLC13A4 - Solute carrier family 13 member 4 - Homo sapiens (Human) - SLC13A4 gene Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV). Taurus_UMD|evm.model.AC_000161.1.601 Q6UWF9 F180A_HUMAN 83.815 0.988506 1.00578 FAM180A - Protein FAM180A precursor - Homo sapiens (Human) - FAM180A gene Taurus_UMD|evm.model.AC_000161.1.602 P58546 MTPN_HUMAN 100.000 0.983193 1.00847 MTPN - Myotrophin - Homo sapiens (Human) - MTPN gene Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Taurus_UMD|evm.model.AC_000161.1.603 O00566 MPP10_HUMAN 74.872 0.989796 0.287812 MPHOSPH10 - U3 small nucleolar ribonucleoprotein protein MPP10 - Homo sapiens (Human) - MPHOSPH10 gene Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Taurus_UMD|evm.model.AC_000161.1.604 O00566 MPP10_HUMAN 84.599 0.995736 0.688693 MPHOSPH10 - U3 small nucleolar ribonucleoprotein protein MPP10 - Homo sapiens (Human) - MPHOSPH10 gene Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Taurus_UMD|evm.model.AC_000161.1.605 P41985 ACM2_BOVIN 100.000 0.995708 1.00215 CHRM2 - Muscarinic acetylcholine receptor M2 - Bos taurus (Bovine) - CHRM2 gene The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol (By similarity). Taurus_UMD|evm.model.AC_000161.1.606 P21782 PTN_BOVIN 100.000 0.988166 1.00595 PTN - Pleiotrophin precursor - Bos taurus (Bovine) - PTN gene Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (PubMed:1550956) (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway. Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway. Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (By similarity). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (By similarity). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion. Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (By similarity). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway. Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration. In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (By similarity). Taurus_UMD|evm.model.AC_000161.1.608 O75912 DGKI_HUMAN 97.810 0.84472 0.151174 DGKI - Diacylglycerol kinase iota - Homo sapiens (Human) - DGKI gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9830018, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (PubMed:9830018). By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity). Taurus_UMD|evm.model.AC_000161.1.609 F1MAB7 DGKI_RAT 85.752 0.98806 0.638095 Dgki - Diacylglycerol kinase iota - Rattus norvegicus (Rat) - Dgki gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15024004). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (PubMed:15024004). By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity). Taurus_UMD|evm.model.AC_000161.1.610 F1MAB7 DGKI_RAT 92.308 0.546099 0.134286 Dgki - Diacylglycerol kinase iota - Rattus norvegicus (Rat) - Dgki gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15024004). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (PubMed:15024004). By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity). Taurus_UMD|evm.model.AC_000161.1.611 Q5RCM9 CR3L2_PONAB 82.885 0.995708 0.896154 CREB3L2 - Cyclic AMP-responsive element-binding protein 3-like protein 2 - Pongo abelii (Sumatran orangutan) - CREB3L2 gene Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site (By similarity). Taurus_UMD|evm.model.AC_000161.1.612 P51857 AK1D1_HUMAN 90.798 0.993884 1.00307 AKR1D1 - Aldo-keto reductase family 1 member D1 - Homo sapiens (Human) - AKR1D1 gene Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one). Taurus_UMD|evm.model.AC_000161.1.614 O15164 TIF1A_HUMAN 96.667 0.998097 1.00095 TRIM24 - Transcription intermediary factor 1-alpha - Homo sapiens (Human) - TRIM24 gene Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Taurus_UMD|evm.model.AC_000161.1.615 Q8N434 SVOPL_HUMAN 92.843 0.977956 1.01423 SVOPL - Putative transporter SVOPL - Homo sapiens (Human) - SVOPL gene Taurus_UMD|evm.model.AC_000161.1.616 Q9HBG4 VPP4_HUMAN 85.714 0.997605 0.994048 ATP6V0A4 - V-type proton ATPase 116 kDa subunit a isoform 4 - Homo sapiens (Human) - ATP6V0A4 gene Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney. Taurus_UMD|evm.model.AC_000161.1.617 Q58CU5 TM213_BOVIN 100.000 0.981651 1.00926 TMEM213 - Transmembrane protein 213 precursor - Bos taurus (Bovine) - TMEM213 gene Taurus_UMD|evm.model.AC_000161.1.619 Q9HCM3 K1549_HUMAN 75.683 0.994748 0.97641 KIAA1549 - UPF0606 protein KIAA1549 - Homo sapiens (Human) - KIAA1549 gene May play a role in photoreceptor function. Taurus_UMD|evm.model.AC_000161.1.620 Q96H79 ZCCHL_HUMAN 81.081 0.976589 0.996667 ZC3HAV1L - Zinc finger CCCH-type antiviral protein 1-like - Homo sapiens (Human) - ZC3HAV1L gene cytosol Taurus_UMD|evm.model.AC_000161.1.621 Q3UPF5 ZCCHV_MOUSE 64.035 0.379041 0.948203 Zc3hav1 - Zinc finger CCCH-type antiviral protein 1 - Mus musculus (Mouse) - Zc3hav1 gene Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1) and moloney and murine leukemia virus (MoMLV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). Taurus_UMD|evm.model.AC_000161.1.622 Q8BS45 IFT56_MOUSE 97.653 0.996396 1.00181 Ttc26 - Intraflagellar transport protein 56 - Mus musculus (Mouse) - Ttc26 gene Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU (PubMed:22718903, PubMed:25340710). Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme (PubMed:28264835). Taurus_UMD|evm.model.AC_000161.1.623 E1B7L7 UBN2_BOVIN 100.000 0.998497 1.00075 UBN2 - Ubinuclein-2 - Bos taurus (Bovine) - UBN2 gene Taurus_UMD|evm.model.AC_000161.1.625 Q3SZA2 FMC1_BOVIN 100.000 0.982456 1.00885 FMC1 - Protein FMC1 homolog - Bos taurus (Bovine) - FMC1 gene Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V). Taurus_UMD|evm.model.AC_000161.1.626 Q7TNC4 LC7L2_MOUSE 98.980 0.994911 1.00255 Luc7l2 - Putative RNA-binding protein Luc7-like 2 - Mus musculus (Mouse) - Luc7l2 gene May bind to RNA via its Arg/Ser-rich domain. Taurus_UMD|evm.model.AC_000161.1.627 A4D1S0 KLRG2_HUMAN 63.065 0.994898 0.958435 KLRG2 - Killer cell lectin-like receptor subfamily G member 2 - Homo sapiens (Human) - KLRG2 gene Taurus_UMD|evm.model.AC_000161.1.628 P0C7M8 CLC2L_HUMAN 96.667 0.675472 1.23832 CLEC2L - C-type lectin domain family 2 member L - Homo sapiens (Human) - CLEC2L gene Taurus_UMD|evm.model.AC_000161.1.629 Q9H2X6 HIPK2_HUMAN 96.725 0.998321 0.994157 HIPK2 - Homeodomain-interacting protein kinase 2 - Homo sapiens (Human) - HIPK2 gene Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Taurus_UMD|evm.model.AC_000161.1.630 Q2KIG5 THAS_BOVIN 99.625 0.996255 1.00188 TBXAS1 - Thromboxane-A synthase - Bos taurus (Bovine) - TBXAS1 gene Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE. Taurus_UMD|evm.model.AC_000161.1.631 Q9H0J9 PAR12_HUMAN 73.826 0.997155 1.00285 PARP12 - Protein mono-ADP-ribosyltransferase PARP12 - Homo sapiens (Human) - PARP12 gene Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Taurus_UMD|evm.model.AC_000161.1.632 Q6ZMT4 KDM7A_HUMAN 93.158 0.867327 1.07333 KDM7A - Lysine-specific demethylase 7A - Homo sapiens (Human) - KDM7A gene Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. Taurus_UMD|evm.model.AC_000161.1.633 Q17QZ3 SPX3_BOVIN 100.000 0.995968 1.00202 SLC37A3 - Sugar phosphate exchanger 3 - Bos taurus (Bovine) - SLC37A3 gene integral component of endoplasmic reticulum membrane Taurus_UMD|evm.model.AC_000161.1.634 Q3ZC27 RAB19_BOVIN 100.000 0.990826 1.00461 RAB19 - Ras-related protein Rab-19 - Bos taurus (Bovine) - RAB19 gene endomembrane system, GTPase activity, autophagosome assembly, intracellular protein transport Taurus_UMD|evm.model.AC_000161.1.635 Q9UHC7 MKRN1_HUMAN 95.455 0.995204 0.865145 MKRN1 - E3 ubiquitin-protein ligase makorin-1 - Homo sapiens (Human) - MKRN1 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. Taurus_UMD|evm.model.AC_000161.1.637 Q9ULE3 DEN2A_HUMAN 87.488 0.987292 1.01388 DENND2A - DENN domain-containing protein 2A - Homo sapiens (Human) - DENND2A gene Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport. Taurus_UMD|evm.model.AC_000161.1.638 Q7Z695 ADCK2_HUMAN 78.812 0.992013 1 ADCK2 - Uncharacterized aarF domain-containing protein kinase 2 - Homo sapiens (Human) - ADCK2 gene The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr). Taurus_UMD|evm.model.AC_000161.1.639 Q02374 NDUB2_BOVIN 100.000 0.981651 1.00926 NDUFB2 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor - Bos taurus (Bovine) - NDUFB2 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000161.1.640 P10533 RMIL_AVII1 99.183 0.477184 2.08992 V-RMIL - Serine/threonine-protein kinase-transforming protein Rmil - Avian retrovirus IC10 - V-RMIL gene Taurus_UMD|evm.model.AC_000161.1.641 P82926 RT33_BOVIN 100.000 0.981308 1.00943 MRPS33 - 28S ribosomal protein S33, mitochondrial - Bos taurus (Bovine) - MRPS33 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion Taurus_UMD|evm.model.AC_000161.1.644 H3BS89 T178B_HUMAN 98.802 0.523659 1.07823 TMEM178B - Transmembrane protein 178B precursor - Homo sapiens (Human) - TMEM178B gene membrane Taurus_UMD|evm.model.AC_000161.1.647 P46783 RS10_HUMAN 72.414 0.982609 0.69697 RPS10 - 40S ribosomal protein S10 - Homo sapiens (Human) - RPS10 gene Component of the 40S ribosomal subunit. Taurus_UMD|evm.model.AC_000161.1.648 H3BS89 T178B_HUMAN 98.462 0.553648 0.792517 TMEM178B - Transmembrane protein 178B precursor - Homo sapiens (Human) - TMEM178B gene membrane Taurus_UMD|evm.model.AC_000161.1.650 Q53H12 AGK_HUMAN 91.232 0.995249 0.99763 AGK - Acylglycerol kinase, mitochondrial - Homo sapiens (Human) - AGK gene Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15939762). Does not phosphorylate sphingosine (PubMed:15939762). Phosphorylates ceramide (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (PubMed:28712724, PubMed:28712726). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (PubMed:28712724, PubMed:28712726). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (PubMed:28712724). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (PubMed:15939762). Taurus_UMD|evm.model.AC_000161.1.651 A4D1U4 DEN11_HUMAN 98.077 0.994521 0.802198 DENND11 - DENN domain-containing protein 11 - Homo sapiens (Human) - DENND11 gene Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Taurus_UMD|evm.model.AC_000161.1.652 A4PES0 WEE2_PIG 77.168 0.739816 1.3469 WEE2 - Wee1-like protein kinase 2 - Sus scrofa (Pig) - WEE2 gene Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. Taurus_UMD|evm.model.AC_000161.1.653 Q646E8 TA2R3_PAPHA 68.910 0.981073 1.00635 TAS2R3 - Taste receptor type 2 member 3 - Papio hamadryas (Hamadryas baboon) - TAS2R3 gene Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). Taurus_UMD|evm.model.AC_000161.1.654 Q646E6 TA2R5_PAPHA 56.997 0.991667 0.802676 TAS2R5 - Taste receptor type 2 member 5 - Papio hamadryas (Hamadryas baboon) - TAS2R5 gene Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Taurus_UMD|evm.model.AC_000161.1.655 Q32KU2 PRS37_BOVIN 100.000 0.991525 1.00426 PRSS37 - Probable inactive serine protease 37 precursor - Bos taurus (Bovine) - PRSS37 gene Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system. Taurus_UMD|evm.model.AC_000161.1.656 Q8IYP2 PRS58_HUMAN 35.685 0.991597 0.987552 PRSS58 - Serine protease 58 precursor - Homo sapiens (Human) - PRSS58 gene secretory granule Taurus_UMD|evm.model.AC_000161.1.657 Q9NY25 CLC5A_HUMAN 77.174 0.968085 0.5 CLEC5A - C-type lectin domain family 5 member A - Homo sapiens (Human) - CLEC5A gene Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP (PubMed:10449773). Regulates inflammatory responses (By similarity). Taurus_UMD|evm.model.AC_000161.1.658 Q697L5 T2R38_PANTR 68.580 0.982143 1.00901 TAS2R38 - Taste receptor type 2 member 38 - Pan troglodytes (Chimpanzee) - TAS2R38 gene Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Taurus_UMD|evm.model.AC_000161.1.659 O43451 MGA_HUMAN 84.429 0.997271 0.986537 MGAM - Maltase-glucoamylase, intestinal - Homo sapiens (Human) - MGAM gene May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing. Taurus_UMD|evm.model.AC_000161.1.660 Q2M2H8 MGAL_HUMAN 68.682 0.922633 1.033 MGAM2 - Probable maltase-glucoamylase 2 - Homo sapiens (Human) - MGAM2 gene alpha-1,4-glucosidase activity, hydrolase activity, hydrolyzing O-glycosyl compounds Taurus_UMD|evm.model.AC_000161.1.661 A6NHM9 MOXD2_HUMAN 87.712 0.794266 1.18838 MOXD2P - Putative DBH-like monooxygenase protein 2 precursor - Homo sapiens (Human) - MOXD2P gene extracellular space, secretory granule membrane, copper ion binding, dopamine beta-monooxygenase activity, dopamine catabolic process, norepinephrine biosynthetic process, octopamine biosynthetic process Taurus_UMD|evm.model.AC_000161.1.662 P04214 TVB6_MOUSE 62.500 0.7 1.10294 T-cell receptor beta chain V region E1 precursor - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000161.1.664 Q32LI2 PRS58_BOVIN 100.000 0.983673 1.0124 PRSS58 - Probable inactive serine protease 58 precursor - Bos taurus (Bovine) - PRSS58 gene secretory granule Taurus_UMD|evm.model.AC_000161.1.665 Q8BW11 PRS58_MOUSE 35.577 0.836066 1.01245 Prss58 - Putative inactive serine protease 58 precursor - Mus musculus (Mouse) - Prss58 gene secretory granule Taurus_UMD|evm.model.AC_000161.1.666 P00760 TRY1_BOVIN 100.000 0.991903 1.00407 Cationic trypsin precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000161.1.667 P00760 TRY1_BOVIN 100.000 0.991903 1.00407 Cationic trypsin precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000161.1.668 A0A576 TVB31_HUMAN 72.566 0.982456 1 TRBV3-1 - T cell receptor beta variable 3-1 precursor - Homo sapiens (Human) - TRBV3-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.669 A0A577 TVB41_HUMAN 68.687 0.163062 5.27193 TRBV4-1 - T cell receptor beta variable 4-1 precursor - Homo sapiens (Human) - TRBV4-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.670 A0A0K0K1A5 TVB65_HUMAN 68.687 0.725926 1.18421 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.671 P63170 DYL1_RAT 84.146 0.55102 1.65169 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Taurus_UMD|evm.model.AC_000161.1.672 A0A0K0K1A5 TVB65_HUMAN 66.667 0.736842 1.16667 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.673 A0A0B4J1U6 TVB9_HUMAN 66.000 0.71223 1.2193 TRBV9 - T cell receptor beta variable 9 precursor - Homo sapiens (Human) - TRBV9 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.674 A0A0B4J1U6 TVB9_HUMAN 70.796 0.427481 2.29825 TRBV9 - T cell receptor beta variable 9 precursor - Homo sapiens (Human) - TRBV9 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.675 A0A0K0K1D8 TVB61_HUMAN 64.602 0.823529 1.19298 TRBV6-1 - T cell receptor beta variable 6-1 precursor - Homo sapiens (Human) - TRBV6-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.676 A0A0K0K1A5 TVB65_HUMAN 67.677 0.75969 1.13158 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.677 P11364 TCB_FLV 67.826 0.850746 0.417445 V-TCR - Viral T-cell receptor beta chain-like T17T-22 precursor - Feline leukemia virus - V-TCR gene Taurus_UMD|evm.model.AC_000161.1.678 A0A0K0K1A5 TVB65_HUMAN 66.667 0.736842 1.16667 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.679 A0A0B4J1U6 TVB9_HUMAN 70.796 0.232848 4.2193 TRBV9 - T cell receptor beta variable 9 precursor - Homo sapiens (Human) - TRBV9 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.680 P11364 TCB_FLV 68.142 0.373333 0.934579 V-TCR - Viral T-cell receptor beta chain-like T17T-22 precursor - Feline leukemia virus - V-TCR gene Taurus_UMD|evm.model.AC_000161.1.681 A0A577 TVB41_HUMAN 67.677 0.550562 1.5614 TRBV4-1 - T cell receptor beta variable 4-1 precursor - Homo sapiens (Human) - TRBV4-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.682 A0A0K0K1A5 TVB65_HUMAN 66.667 0.753846 1.14035 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.683 A0A0B4J1U6 TVB9_HUMAN 63.717 0.513761 1.91228 TRBV9 - T cell receptor beta variable 9 precursor - Homo sapiens (Human) - TRBV9 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.684 A0A0K0K1A5 TVB65_HUMAN 65.657 0.720588 1.19298 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.685 A0A0K0K1A5 TVB65_HUMAN 65.657 0.289941 2.96491 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.686 A0A0K0K1A5 TVB65_HUMAN 67.010 0.223256 3.77193 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.687 P06320 TVB7_MOUSE 70.000 0.303681 2.43284 T-cell receptor beta chain V region CTL-F3 precursor - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000161.1.688 A0A0B4J2E0 TVBL4_HUMAN 71.930 0.339339 2.89565 TRBV12-4 - T cell receptor beta variable 12-4 precursor - Homo sapiens (Human) - TRBV12-4 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.689 A0A087WV62 TVB16_HUMAN 67.742 0.380753 2.07826 TRBV16 - T cell receptor beta variable 16 precursor - Homo sapiens (Human) - TRBV16 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.690 A0A075B6N1 TVB19_HUMAN 68.254 0.352273 1.54386 TRBV19 - T cell receptor beta variable 19 precursor - Homo sapiens (Human) - TRBV19 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.691 A0A087WV62 TVB16_HUMAN 48.936 0.877358 0.921739 TRBV16 - T cell receptor beta variable 16 precursor - Homo sapiens (Human) - TRBV16 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.692 A0A075B6N1 TVB19_HUMAN 68.468 0.486726 1.98246 TRBV19 - T cell receptor beta variable 19 precursor - Homo sapiens (Human) - TRBV19 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.693 A0A0A0MS06 TVB23_HUMAN 56.122 0.687943 1.22609 TRBV23-1 - Probable non-functional T cell receptor beta variable 23-1 precursor - Homo sapiens (Human) - TRBV23-1 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.694 A0A0A0MS06 TVB23_HUMAN 52.128 0.659574 1.22609 TRBV23-1 - Probable non-functional T cell receptor beta variable 23-1 precursor - Homo sapiens (Human) - TRBV23-1 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.695 A0A0A0MS06 TVB23_HUMAN 55.102 0.776 1.08696 TRBV23-1 - Probable non-functional T cell receptor beta variable 23-1 precursor - Homo sapiens (Human) - TRBV23-1 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.696 A0A0A0MS06 TVB23_HUMAN 56.122 0.774194 1.07826 TRBV23-1 - Probable non-functional T cell receptor beta variable 23-1 precursor - Homo sapiens (Human) - TRBV23-1 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.697 A0A075B6N1 TVB19_HUMAN 67.708 0.29321 2.84211 TRBV19 - T cell receptor beta variable 19 precursor - Homo sapiens (Human) - TRBV19 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.698 A0A087WV62 TVB16_HUMAN 52.525 0.75969 1.12174 TRBV16 - T cell receptor beta variable 16 precursor - Homo sapiens (Human) - TRBV16 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.699 A0A0A0MS06 TVB23_HUMAN 56.122 0.776 1.08696 TRBV23-1 - Probable non-functional T cell receptor beta variable 23-1 precursor - Homo sapiens (Human) - TRBV23-1 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.700 A0A075B6N2 TVBT1_HUMAN 63.542 0.625 1.36937 TRBV20-1 - T cell receptor beta variable 20-1 precursor - Homo sapiens (Human) - TRBV20-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.701 A0A087WV62 TVB16_HUMAN 56.566 0.348754 2.44348 TRBV16 - T cell receptor beta variable 16 precursor - Homo sapiens (Human) - TRBV16 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.702 A0A087WV62 TVB16_HUMAN 53.509 0.904 1.08696 TRBV16 - T cell receptor beta variable 16 precursor - Homo sapiens (Human) - TRBV16 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.703 A0A0A0MS06 TVB23_HUMAN 52.041 0.776 1.08696 TRBV23-1 - Probable non-functional T cell receptor beta variable 23-1 precursor - Homo sapiens (Human) - TRBV23-1 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain (PubMed:24600447). Non-functional ORF generally cannot participate to the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.704 A0A075B6N1 TVB19_HUMAN 61.856 0.688406 1.21053 TRBV19 - T cell receptor beta variable 19 precursor - Homo sapiens (Human) - TRBV19 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.705 A0A075B6N3 TVBX1_HUMAN 67.257 0.565657 1.72174 TRBV24-1 - T cell receptor beta variable 24-1 precursor - Homo sapiens (Human) - TRBV24-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.706 A0A075B6N4 TVBY1_HUMAN 74.561 0.81295 1.2193 TRBV25-1 - T cell receptor beta variable 25-1 precursor - Homo sapiens (Human) - TRBV25-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.707 A0A0K0K1C4 TVB27_HUMAN 60.177 0.794326 1.23684 TRBV27 - T cell receptor beta variable 27 precursor - Homo sapiens (Human) - TRBV27 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.708 A0A0K0K1C4 TVB27_HUMAN 64.602 0.949153 1.03509 TRBV27 - T cell receptor beta variable 27 precursor - Homo sapiens (Human) - TRBV27 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.709 A0A5B6 TVB28_HUMAN 73.529 0.212025 2.77193 TRBV28 - T cell receptor beta variable 28 precursor - Homo sapiens (Human) - TRBV28 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.710 A0A5B7 TVB29_HUMAN 74.227 0.227488 3.8018 TRBV29-1 - T cell receptor beta variable 29-1 precursor - Homo sapiens (Human) - TRBV29-1 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.711 Q29463 TRY2_BOVIN 98.381 0.991935 1.00405 Anionic trypsin precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000161.1.712 A0A5B9 TRBC2_HUMAN 83.041 0.397196 2.40449 TRBC2 - T cell receptor beta constant 2 - Homo sapiens (Human) - TRBC2 gene Constant region of T cell receptor (TR) beta chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.713 A0A5B9 TRBC2_HUMAN 81.356 0.742616 1.33146 TRBC2 - T cell receptor beta constant 2 - Homo sapiens (Human) - TRBC2 gene Constant region of T cell receptor (TR) beta chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.714 A0A0K0K1B3 TVB30_HUMAN 73.737 0.720588 1.22523 TRBV30 - T cell receptor beta variable 30 precursor - Homo sapiens (Human) - TRBV30 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.715 P0C0K6 EPHB6_PANTR 91.373 0.998016 0.988235 EPHB6 - Ephrin type-B receptor 6 precursor - Pan troglodytes (Chimpanzee) - EPHB6 gene Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity). Taurus_UMD|evm.model.AC_000161.1.716 Q9H1D0 TRPV6_HUMAN 83.034 0.99723 0.943791 TRPV6 - Transient receptor potential cation channel subfamily V member 6 - Homo sapiens (Human) - TRPV6 gene Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Taurus_UMD|evm.model.AC_000161.1.717 Q9XSM3 TRPV5_RABIT 82.645 0.990437 1.00274 Trpv5 - Transient receptor potential cation channel subfamily V member 5 - Oryctolagus cuniculus (Rabbit) - Trpv5 gene Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:10085067, PubMed:11035011, PubMed:12574114, PubMed:29323279). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:29323279). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (PubMed:11035011). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114). Taurus_UMD|evm.model.AC_000161.1.718 Q96L11 LCFC1_HUMAN 63.810 0.971963 0.877049 LLCFC1 - Sperm-egg fusion protein LLCFC1 precursor - Homo sapiens (Human) - LLCFC1 gene Sperm protein required for fusion of sperm with the egg membrane during fertilization. Taurus_UMD|evm.model.AC_000161.1.719 P23276 KELL_HUMAN 67.967 0.99169 0.986339 KEL - Kell blood group glycoprotein - Homo sapiens (Human) - KEL gene Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. Taurus_UMD|evm.model.AC_000161.1.721 A0A0B4J1U6 TVB9_HUMAN 63.918 0.463768 1.81579 TRBV9 - T cell receptor beta variable 9 precursor - Homo sapiens (Human) - TRBV9 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000161.1.722 Q8NGT5 OR9A2_HUMAN 79.116 0.99187 0.793548 OR9A2 - Olfactory receptor 9A2 - Homo sapiens (Human) - OR9A2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000161.1.723 Q8NGT5 OR9A2_HUMAN 79.422 0.99278 0.893548 OR9A2 - Olfactory receptor 9A2 - Homo sapiens (Human) - OR9A2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000161.1.724 Q8N148 OR6V1_HUMAN 78.616 0.98 0.479233 OR6V1 - Olfactory receptor 6V1 - Homo sapiens (Human) - OR6V1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000161.1.726 P60986 PIP_BOVIN 40.476 0.836735 1.01379 PIP - Prolactin-inducible protein homolog precursor - Bos taurus (Bovine) - PIP gene extracellular space, aspartic-type endopeptidase activity, proteolysis, regulation of immune system process Taurus_UMD|evm.model.AC_000161.1.727 P60986 PIP_BOVIN 36.567 0.851351 1.02069 PIP - Prolactin-inducible protein homolog precursor - Bos taurus (Bovine) - PIP gene extracellular space, aspartic-type endopeptidase activity, proteolysis, regulation of immune system process Taurus_UMD|evm.model.AC_000161.1.728 P60986 PIP_BOVIN 37.405 0.85034 1.01379 PIP - Prolactin-inducible protein homolog precursor - Bos taurus (Bovine) - PIP gene extracellular space, aspartic-type endopeptidase activity, proteolysis, regulation of immune system process Taurus_UMD|evm.model.AC_000161.1.729 P59534 T2R39_HUMAN 64.286 0.962644 1.02959 TAS2R39 - Taste receptor type 2 member 39 - Homo sapiens (Human) - TAS2R39 gene Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Taurus_UMD|evm.model.AC_000161.1.730 Q646F2 T2R40_PAPHA 64.961 0.836299 0.869969 TAS2R40 - Taste receptor type 2 member 40 - Papio hamadryas (Hamadryas baboon) - TAS2R40 gene Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). Taurus_UMD|evm.model.AC_000161.1.731 Q9Y2Q3 GSTK1_HUMAN 77.434 0.991189 1.00442 GSTK1 - Glutathione S-transferase kappa 1 - Homo sapiens (Human) - GSTK1 gene Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB). Taurus_UMD|evm.model.AC_000161.1.732 Q8IV31 TM139_HUMAN 65.741 0.990431 0.967593 TMEM139 - Transmembrane protein 139 precursor - Homo sapiens (Human) - TMEM139 gene May be involved in cellular trafficking of proteins such as SLC4A1. Taurus_UMD|evm.model.AC_000161.1.733 P42575 CASP2_HUMAN 88.053 0.995585 1.00221 CASP2 - Caspase-2 precursor - Homo sapiens (Human) - CASP2 gene Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). Taurus_UMD|evm.model.AC_000161.1.734 P35523 CLCN1_HUMAN 87.867 0.997978 1.00101 CLCN1 - Chloride channel protein 1 - Homo sapiens (Human) - CLCN1 gene Voltage-gated chloride channel (PubMed:8112288, PubMed:9122265, PubMed:12456816). Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (Probable). The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). Taurus_UMD|evm.model.AC_000161.1.735 A0JNG6 F131B_BOVIN 100.000 0.767313 1.0649 FAM131B - Protein FAM131B - Bos taurus (Bovine) - FAM131B gene Taurus_UMD|evm.model.AC_000161.1.736 Q15942 ZYX_HUMAN 87.040 0.977233 0.998252 ZYX - Zyxin - Homo sapiens (Human) - ZYX gene Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). Taurus_UMD|evm.model.AC_000161.1.737 P21709 EPHA1_HUMAN 87.386 0.997967 1.0082 EPHA1 - Ephrin type-A receptor 1 precursor - Homo sapiens (Human) - EPHA1 gene Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. Taurus_UMD|evm.model.AC_000161.1.738 Q7TQB0 TR134_MOUSE 62.044 0.957447 0.473154 Tas2r134 - Taste receptor type 2 member 134 - Mus musculus (Mouse) - Tas2r134 gene Putative taste receptor which may play a role in the perception of bitterness. Taurus_UMD|evm.model.AC_000161.1.739 Q5Y4Z0 T2R62_PANPA 61.111 0.834646 0.407051 TAS2R62 - Taste receptor type 2 member 62 - Pan paniscus (Pygmy chimpanzee) - TAS2R62 gene Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Taurus_UMD|evm.model.AC_000161.1.740 Q645Y3 T2R41_GORGO 65.683 0.895973 0.970684 TAS2R41 - Taste receptor type 2 member 41 - Gorilla gorilla gorilla (Western lowland gorilla) - TAS2R41 gene Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Taurus_UMD|evm.model.AC_000161.1.741 Q13607 OR2F1_HUMAN 55.895 0.974359 0.73817 OR2F1 - Olfactory receptor 2F1 - Homo sapiens (Human) - OR2F1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000161.1.742 Q8NH08 O10AC_HUMAN 82.243 0.981595 1.00308 OR10AC1 - Olfactory receptor 10AC1 - Homo sapiens (Human) - OR10AC1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000161.1.743 A6QLU7 TCAF2_BOVIN 99.891 0.997814 1.00109 TCAF2 - TRPM8 channel-associated factor 2 - Bos taurus (Bovine) - TCAF2 gene Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner. Taurus_UMD|evm.model.AC_000161.1.744 A5PJN5 TCAF1_BOVIN 99.891 0.927419 1.07709 TCAF1 - TRPM8 channel-associated factor 1 - Bos taurus (Bovine) - TCAF1 gene Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner. Taurus_UMD|evm.model.AC_000161.1.745 Q95156 OLF3_CANLF 87.365 0.99639 0.873817 Olfactory receptor-like protein OLF3 - Canis lupus familiaris (Dog) Taurus_UMD|evm.model.AC_000161.1.746 Q95156 OLF3_CANLF 65.455 0.981818 0.173502 Olfactory receptor-like protein OLF3 - Canis lupus familiaris (Dog) Taurus_UMD|evm.model.AC_000161.1.747 A4D2G3 O2A25_HUMAN 85.981 0.990654 0.345161 OR2A25 - Olfactory receptor 2A25 - Homo sapiens (Human) - OR2A25 gene Odorant receptor. Taurus_UMD|evm.model.AC_000161.1.749 P30274 CCNA2_BOVIN 84.826 0.991736 0.844186 CCNA2 - Cyclin-A2 - Bos taurus (Bovine) - CCNA2 gene Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Taurus_UMD|evm.model.AC_000161.1.750 Q6IF42 OR2A2_HUMAN 64.205 0.988701 0.556604 OR2A2 - Olfactory receptor 2A2 - Homo sapiens (Human) - OR2A2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000161.1.751 Q12774 ARHG5_HUMAN 64.640 0.955314 1.03694 ARHGEF5 - Rho guanine nucleotide exchange factor 5 - Homo sapiens (Human) - ARHGEF5 gene Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). Taurus_UMD|evm.model.AC_000161.1.752 O60393 NOBOX_HUMAN 59.967 0.977032 0.819103 NOBOX - Homeobox protein NOBOX - Homo sapiens (Human) - NOBOX gene Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. Taurus_UMD|evm.model.AC_000161.1.753 Q5E9T4 TPK1_BOVIN 100.000 0.991803 1.00412 TPK1 - Thiamin pyrophosphokinase 1 - Bos taurus (Bovine) - TPK1 gene Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate (By similarity). Taurus_UMD|evm.model.AC_000161.1.755 Q53H47 SETMR_HUMAN 36.458 0.893204 0.150585 SETMAR - Histone-lysine N-methyltransferase SETMAR - Homo sapiens (Human) - SETMAR gene Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750). Taurus_UMD|evm.model.AC_000161.1.756 Q9CPW0 CNTP2_MOUSE 95.747 0.9 0.645646 Cntnap2 - Contactin-associated protein-like 2 precursor - Mus musculus (Mouse) - Cntnap2 gene Required for gap junction formation (By similarity). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons (PubMed:25378149). Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction (Probable) (PubMed:25378149). Taurus_UMD|evm.model.AC_000161.1.757 Q9WTX6 CUL1_MOUSE 99.871 0.997426 1.00129 Cul1 - Cullin-1 - Mus musculus (Mouse) - Cul1 gene Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Taurus_UMD|evm.model.AC_000161.1.759 Q15910 EZH2_HUMAN 98.660 0.98285 1.01609 EZH2 - Histone-lysine N-methyltransferase EZH2 - Homo sapiens (Human) - EZH2 gene Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. Taurus_UMD|evm.model.AC_000161.1.761 Q29RV1 PDIA4_BOVIN 99.689 0.996894 1.00156 PDIA4 - Protein disulfide-isomerase A4 precursor - Bos taurus (Bovine) - PDIA4 gene Taurus_UMD|evm.model.AC_000161.1.762 Q8N393 ZN786_HUMAN 54.867 0.997187 0.909207 ZNF786 - Zinc finger protein 786 - Homo sapiens (Human) - ZNF786 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000161.1.763 Q8TD17 ZN398_HUMAN 88.629 0.99688 0.998442 ZNF398 - Zinc finger protein 398 - Homo sapiens (Human) - ZNF398 gene Functions as a transcriptional activator. Taurus_UMD|evm.model.AC_000161.1.764 Q9UDV7 ZN282_HUMAN 94.495 0.522892 0.61848 ZNF282 - Zinc finger protein 282 - Homo sapiens (Human) - ZNF282 gene Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression. Taurus_UMD|evm.model.AC_000161.1.765 Q75MW2 ZN767_HUMAN 83.333 0.209979 3.10323 ZNF767P - Protein ZNF767 - Homo sapiens (Human) - ZNF767P gene Taurus_UMD|evm.model.AC_000161.1.766 Q75MW2 ZN767_HUMAN 78.218 0.16835 3.83226 ZNF767P - Protein ZNF767 - Homo sapiens (Human) - ZNF767P gene Taurus_UMD|evm.model.AC_000161.1.767 Q9ULD5 ZN777_HUMAN 91.827 0.997599 1.00241 ZNF777 - Zinc finger protein 777 - Homo sapiens (Human) - ZNF777 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000161.1.768 Q75MW2 ZN767_HUMAN 95.370 0.173701 3.97419 ZNF767P - Protein ZNF767 - Homo sapiens (Human) - ZNF767P gene Taurus_UMD|evm.model.AC_000161.1.769 A5PL33 KRBA1_HUMAN 60.898 0.627534 1.14951 KRBA1 - Protein KRBA1 - Homo sapiens (Human) - KRBA1 gene Taurus_UMD|evm.model.AC_000161.1.771 Q7Z7K2 ZN467_HUMAN 79.483 0.99651 0.963025 ZNF467 - Zinc finger protein 467 - Homo sapiens (Human) - ZNF467 gene Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity). Taurus_UMD|evm.model.AC_000161.1.772 P98167 SSPO_BOVIN 98.918 0.0989628 0.899339 SSPO - SCO-spondin precursor - Bos taurus (Bovine) - SSPO gene Involved in the modulation of neuronal aggregation (PubMed:8743952). May be involved in developmental events during the formation of the central nervous system (PubMed:11008217). Taurus_UMD|evm.model.AC_000161.1.773 O60290 ZN862_HUMAN 80.496 0.992301 1 ZNF862 - Zinc finger protein 862 - Homo sapiens (Human) - ZNF862 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000161.1.774 Q2KIB5 VA0E2_BOVIN 100.000 0.97561 1.01235 ATP6V0E2 - V-type proton ATPase subunit e 2 - Bos taurus (Bovine) - ATP6V0E2 gene Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Taurus_UMD|evm.model.AC_000161.1.775 Q29RS5 RARR2_BOVIN 100.000 0.98773 1.00617 RARRES2 - Retinoic acid receptor responder protein 2 precursor - Bos taurus (Bovine) - RARRES2 gene Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Exhibits an antimicrobial function in the skin (By similarity). Taurus_UMD|evm.model.AC_000161.1.776 Q0VCC5 REPI1_BOVIN 100.000 0.996429 1.00179 REPIN1 - Replication initiator 1 - Bos taurus (Bovine) - REPIN1 gene Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending (By similarity). Taurus_UMD|evm.model.AC_000161.1.777 Q96BV0 ZN775_HUMAN 59.363 0.903475 0.964618 ZNF775 - Zinc finger protein 775 - Homo sapiens (Human) - ZNF775 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000161.1.778 Q8ND71 GIMA8_HUMAN 56.716 0.930693 1.06316 GIMAP8 - GTPase IMAP family member 8 - Homo sapiens (Human) - GIMAP8 gene Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. Taurus_UMD|evm.model.AC_000161.1.779 Q8NHV1 GIMA7_HUMAN 62.759 0.979661 0.983333 GIMAP7 - GTPase IMAP family member 7 - Homo sapiens (Human) - GIMAP7 gene The dimer has GTPase activity; the active site contains residues from both subunits. Taurus_UMD|evm.model.AC_000161.1.780 Q96F15 GIMA5_HUMAN 65.789 0.680412 1.26384 GIMAP5 - GTPase IMAP family member 5 - Homo sapiens (Human) - GIMAP5 gene Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Taurus_UMD|evm.model.AC_000161.1.781 Q8NHV1 GIMA7_HUMAN 62.373 0.986577 0.993333 GIMAP7 - GTPase IMAP family member 7 - Homo sapiens (Human) - GIMAP7 gene The dimer has GTPase activity; the active site contains residues from both subunits. Taurus_UMD|evm.model.AC_000161.1.782 Q0V8E4 ASND1_BOVIN 87.500 0.915584 0.240625 ASNSD1 - Asparagine synthetase domain-containing protein 1 - Bos taurus (Bovine) - ASNSD1 gene Taurus_UMD|evm.model.AC_000161.1.783 Q9NUV9 GIMA4_HUMAN 61.180 0.978125 0.972644 GIMAP4 - GTPase IMAP family member 4 - Homo sapiens (Human) - GIMAP4 gene During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. Taurus_UMD|evm.model.AC_000161.1.784 Q65AC2 S26A2_HORSE 73.864 0.720339 0.160326 SLC26A2 - Sulfate transporter - Equus caballus (Horse) - SLC26A2 gene Sulfate transporter. May play a role in endochondral bone formation. Taurus_UMD|evm.model.AC_000161.1.785 Q8NHV1 GIMA7_HUMAN 65.068 0.989796 0.98 GIMAP7 - GTPase IMAP family member 7 - Homo sapiens (Human) - GIMAP7 gene The dimer has GTPase activity; the active site contains residues from both subunits. Taurus_UMD|evm.model.AC_000161.1.786 Q8NHV1 GIMA7_HUMAN 60.345 0.981818 0.916667 GIMAP7 - GTPase IMAP family member 7 - Homo sapiens (Human) - GIMAP7 gene The dimer has GTPase activity; the active site contains residues from both subunits. Taurus_UMD|evm.model.AC_000161.1.787 Q8WWP7 GIMA1_HUMAN 62.319 0.925424 0.964052 GIMAP1 - GTPase IMAP family member 1 - Homo sapiens (Human) - GIMAP1 gene May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). Taurus_UMD|evm.model.AC_000161.1.788 Q9NUV9 GIMA4_HUMAN 60.952 0.9653 0.963526 GIMAP4 - GTPase IMAP family member 4 - Homo sapiens (Human) - GIMAP4 gene During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. Taurus_UMD|evm.model.AC_000161.1.789 A5PKB7 GIMA6_BOVIN 83.908 0.980695 0.759531 GIMAP6 - GTPase IMAP family member 6 - Bos taurus (Bovine) - GIMAP6 gene cytosol Taurus_UMD|evm.model.AC_000161.1.790 Q8NHV1 GIMA7_HUMAN 65.085 0.986577 0.993333 GIMAP7 - GTPase IMAP family member 7 - Homo sapiens (Human) - GIMAP7 gene The dimer has GTPase activity; the active site contains residues from both subunits. Taurus_UMD|evm.model.AC_000161.1.791 Q9UG22 GIMA2_HUMAN 65.441 0.28481 1.40653 GIMAP2 - GTPase IMAP family member 2 - Homo sapiens (Human) - GIMAP2 gene The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. Taurus_UMD|evm.model.AC_000161.1.792 Q96F15 GIMA5_HUMAN 64.041 0.941748 1.00651 GIMAP5 - GTPase IMAP family member 5 - Homo sapiens (Human) - GIMAP5 gene Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Taurus_UMD|evm.model.AC_000161.1.793 Q96F15 GIMA5_HUMAN 59.386 0.948052 1.00326 GIMAP5 - GTPase IMAP family member 5 - Homo sapiens (Human) - GIMAP5 gene Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Taurus_UMD|evm.model.AC_000161.1.794 Q5R8D6 T176B_PONAB 65.683 0.992481 0.985185 TMEM176B - Transmembrane protein 176B - Pongo abelii (Sumatran orangutan) - TMEM176B gene May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity). Taurus_UMD|evm.model.AC_000161.1.795 Q7YQI4 T176A_BOVIN 100.000 0.991736 1.00415 TMEM176A - Transmembrane protein 176A - Bos taurus (Bovine) - TMEM176A gene negative regulation of dendritic cell differentiation Taurus_UMD|evm.model.AC_000161.1.796 Q9TRC7 AOC1_PIG 84.815 0.965608 1.00132 AOC1 - Amiloride-sensitive amine oxidase [copper-containing] precursor - Sus scrofa (Pig) - AOC1 gene Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Taurus_UMD|evm.model.AC_000161.1.797 Q8WNY2 KCNH2_RABIT 96.774 0.141155 0.939707 KCNH2 - Potassium voltage-gated channel subfamily H member 2 - Oryctolagus cuniculus (Rabbit) - KCNH2 gene Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). Taurus_UMD|evm.model.AC_000161.1.798 P29473 NOS3_BOVIN 99.917 0.998342 1.00083 NOS3 - Nitric oxide synthase, endothelial - Bos taurus (Bovine) - NOS3 gene Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Taurus_UMD|evm.model.AC_000161.1.799 Q674R7 ATG9B_HUMAN 83.475 0.99787 1.01623 ATG9B - Autophagy-related protein 9B - Homo sapiens (Human) - ATG9B gene Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity). Taurus_UMD|evm.model.AC_000161.1.800 Q5RFQ9 MITOS_PONAB 87.249 0.97619 0.994429 ABCB8 - Mitochondrial potassium channel ATP-binding subunit precursor - Pongo abelii (Sumatran orangutan) - ABCB8 gene ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane. Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (By similarity). Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity). Taurus_UMD|evm.model.AC_000161.1.801 Q9UHC3 ASIC3_HUMAN 83.459 0.996248 1.00377 ASIC3 - Acid-sensing ion channel 3 - Homo sapiens (Human) - ASIC3 gene Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Taurus_UMD|evm.model.AC_000161.1.802 P49615 CDK5_MOUSE 92.123 0.99278 0.94863 Cdk5 - Cyclin-dependent-like kinase 5 - Mus musculus (Mouse) - Cdk5 gene Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. Taurus_UMD|evm.model.AC_000161.1.803 Q6SJP2 B3A2_HORSE 96.207 0.998387 1.00243 SLC4A2 - Anion exchange protein 2 - Equus caballus (Horse) - SLC4A2 gene Plasma membrane anion exchange protein of wide distribution. Taurus_UMD|evm.model.AC_000161.1.804 Q14296 FASTK_HUMAN 90.727 0.996324 0.990893 FASTK - Fas-activated serine/threonine kinase - Homo sapiens (Human) - FASTK gene Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. Taurus_UMD|evm.model.AC_000161.1.805 Q3ZBI9 TMUB1_BOVIN 100.000 0.830508 1.19919 TMUB1 - Transmembrane and ubiquitin-like domain-containing protein 1 - Bos taurus (Bovine) - TMUB1 gene Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface. Acts as negative regulator of hepatocyte growth during regeneration. Taurus_UMD|evm.model.AC_000161.1.806 Q96P47 AGAP3_HUMAN 89.872 0.939181 0.977143 AGAP3 - Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 - Homo sapiens (Human) - AGAP3 gene GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. Taurus_UMD|evm.model.AC_000161.1.807 Q14549 GBX1_HUMAN 92.632 0.917073 0.564738 GBX1 - Homeobox protein GBX-1 - Homo sapiens (Human) - GBX1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, regulation of nervous system development, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000161.1.808 Q14549 GBX1_HUMAN 92.424 0.777108 0.4573 GBX1 - Homeobox protein GBX-1 - Homo sapiens (Human) - GBX1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, regulation of nervous system development, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000161.1.809 Q8WXI3 ASB10_HUMAN 88.696 0.91018 1.07281 ASB10 - Ankyrin repeat and SOCS box protein 10 - Homo sapiens (Human) - ASB10 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000161.1.810 A0A2R8Y619 H2BE1_HUMAN 88.525 0.128998 7.68852 H2BE1 - Histone H2B type 2-E1 - Homo sapiens (Human) - H2BE1 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000161.1.811 Q2KJA2 ABCF2_BOVIN 100.000 0.904348 1.104 ABCF2 - ATP-binding cassette sub-family F member 2 - Bos taurus (Bovine) - ABCF2 gene ATP binding Taurus_UMD|evm.model.AC_000161.1.812 Q9P2E5 CHPF2_HUMAN 95.424 0.95232 1.00518 CHPF2 - Chondroitin sulfate glucuronyltransferase - Homo sapiens (Human) - CHPF2 gene Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity. Taurus_UMD|evm.model.AC_000161.1.813 Q6STE5 SMRD3_HUMAN 99.781 0.968153 0.975155 SMARCD3 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 - Homo sapiens (Human) - SMARCD3 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Taurus_UMD|evm.model.AC_000161.1.814 Q8MJ87 NUB1_BOVIN 100.000 0.344288 2.8914 NUB1 - NEDD8 ultimate buster 1 - Bos taurus (Bovine) - NUB1 gene Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8 and its conjugates to the proteasome for degradation (By similarity). Taurus_UMD|evm.model.AC_000161.1.815 Q86TI4 WDR86_HUMAN 82.500 0.994924 1.04787 WDR86 - WD repeat-containing protein 86 - Homo sapiens (Human) - WDR86 gene Taurus_UMD|evm.model.AC_000161.1.816 D3ZEG1 CRGN_RAT 92.308 0.989071 1 Crygn - Gamma-crystallin N - Rattus norvegicus (Rat) - Crygn gene Crystallins are the dominant structural components of the vertebrate eye lens. Plays also an important role for integrity and function of auditory nuclei. Taurus_UMD|evm.model.AC_000161.1.817 Q62639 RHEB_RAT 100.000 0.989189 1.00543 Rheb - GTP-binding protein Rheb precursor - Rattus norvegicus (Rat) - Rheb gene Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. Taurus_UMD|evm.model.AC_000161.1.819 Q91WG5 AAKG2_MOUSE 97.518 0.665877 0.745583 Prkag2 - 5'-AMP-activated protein kinase subunit gamma-2 - Mus musculus (Mouse) - Prkag2 gene AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (By similarity). Taurus_UMD|evm.model.AC_000161.1.820 Q5R4S0 AAKG2_PONAB 88.764 0.732218 0.456107 PRKAG2 - 5'-AMP-activated protein kinase subunit gamma-2 - Pongo abelii (Sumatran orangutan) - PRKAG2 gene AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (By similarity). Taurus_UMD|evm.model.AC_000161.1.821 Q95JX4 GLTL5_MACFA 64.430 0.985915 0.961625 GALNTL5 - Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5 - Macaca fascicularis (Crab-eating macaque) - GALNTL5 gene Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region (By similarity). Taurus_UMD|evm.model.AC_000161.1.822 Q8NCW6 GLT11_HUMAN 92.257 0.995058 0.998355 GALNT11 - Polypeptide N-acetylgalactosaminyltransferase 11 - Homo sapiens (Human) - GALNT11 gene Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). Taurus_UMD|evm.model.AC_000161.1.823 Q8NEZ4 KMT2C_HUMAN 82.242 0.991104 1.00713 KMT2C - Histone-lysine N-methyltransferase 2C - Homo sapiens (Human) - KMT2C gene Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. Taurus_UMD|evm.model.AC_000161.1.824 Q96SF2 TCPQM_HUMAN 71.429 0.983178 0.960503 CCT8L2 - T-complex protein 1 subunit theta-like 2 - Homo sapiens (Human) - CCT8L2 gene Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Taurus_UMD|evm.model.AC_000161.1.825 O43543 XRCC2_HUMAN 84.229 0.989324 1.00357 XRCC2 - DNA repair protein XRCC2 - Homo sapiens (Human) - XRCC2 gene Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Taurus_UMD|evm.model.AC_000161.1.826 Q9P1U1 ARP3B_HUMAN 97.368 0.918699 0.294258 ACTR3B - Actin-related protein 3B - Homo sapiens (Human) - ACTR3B gene Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. Taurus_UMD|evm.model.AC_000161.1.827 Q9P1U1 ARP3B_HUMAN 97.232 0.993103 0.69378 ACTR3B - Actin-related protein 3B - Homo sapiens (Human) - ACTR3B gene Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. Taurus_UMD|evm.model.AC_000161.1.828 Q58DW0 RL4_BOVIN 61.364 0.977011 0.206161 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Taurus_UMD|evm.model.AC_000161.1.829 Q58DW0 RL4_BOVIN 64.500 0.945355 0.433649 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Taurus_UMD|evm.model.AC_000161.1.830 Q3ZCH9 HDHD2_BOVIN 91.892 0.973333 0.289575 HDHD2 - Haloacid dehalogenase-like hydrolase domain-containing protein 2 - Bos taurus (Bovine) - HDHD2 gene enzyme binding, phosphatase activity, dephosphorylation Taurus_UMD|evm.model.AC_000161.1.831 Q3ZCB6 PPDPF_BOVIN 86.726 0.965517 1 PPDPF - Pancreatic progenitor cell differentiation and proliferation factor - Bos taurus (Bovine) - PPDPF gene Probable regulator of exocrine pancreas development. Taurus_UMD|evm.model.AC_000161.1.832 Q10126 YSM6_CAEEL 27.273 0.818505 1.00717 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000161.1.838 P42659 DPP6_BOVIN 99.582 0.262115 1.05214 DPP6 - Dipeptidyl aminopeptidase-like protein 6 - Bos taurus (Bovine) - DPP6 gene Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity. Taurus_UMD|evm.model.AC_000161.1.839 A0JNA8 PAXI1_BOVIN 99.544 0.864892 1.03049 PAXIP1 - PAX-interacting protein 1 - Bos taurus (Bovine) - PAXIP1 gene Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Proposed to recruit PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probably independent of MLL-containing histone methyltransferase (HMT) complexes. However, this function has been questioned (By similarity). Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes. Conflictingly, its function in transcriptional regulation during immunoglobulin class switching is reported to be independent of the MLL2/MLL3 complex (By similarity). Taurus_UMD|evm.model.AC_000161.1.840 A0JNC3 INSI1_BOVIN 100.000 0.725594 1.37319 INSIG1 - Insulin-induced gene 1 protein - Bos taurus (Bovine) - INSIG1 gene Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139. Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78. Taurus_UMD|evm.model.AC_000161.1.842 P19622 HME2_HUMAN 94.220 0.784404 0.654655 EN2 - Homeobox protein engrailed-2 - Homo sapiens (Human) - EN2 gene chromatin, fibrillar center, nucleolus, nucleoplasm, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, multicellular organism development, neuron differentiation Taurus_UMD|evm.model.AC_000161.1.843 Q3B7I2 CNPY1_HUMAN 86.250 0.179545 4.78261 CNPY1 - Protein canopy homolog 1 - Homo sapiens (Human) - CNPY1 gene endoplasmic reticulum Taurus_UMD|evm.model.AC_000161.1.844 Q96EV2 RBM33_HUMAN 91.711 0.477929 1.00684 RBM33 - RNA-binding protein 33 - Homo sapiens (Human) - RBM33 gene RNA binding Taurus_UMD|evm.model.AC_000161.1.846 Q15465 SHH_HUMAN 97.326 0.378049 1.06494 SHH - Sonic hedgehog protein precursor - Homo sapiens (Human) - SHH gene The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). Taurus_UMD|evm.model.AC_000161.1.857 Q9H0A6 RNF32_HUMAN 69.589 0.994012 0.922652 RNF32 - RING finger protein 32 - Homo sapiens (Human) - RNF32 gene May play a role in sperm formation. Taurus_UMD|evm.model.AC_000161.1.858 Q8WVP7 LMBR1_HUMAN 93.673 0.995798 0.971429 LMBR1 - Limb region 1 protein homolog - Homo sapiens (Human) - LMBR1 gene Putative membrane receptor. Taurus_UMD|evm.model.AC_000161.1.860 Q5C9Z4 NOM1_HUMAN 70.000 0.973526 0.966279 NOM1 - Nucleolar MIF4G domain-containing protein 1 - Homo sapiens (Human) - NOM1 gene Plays a role in targeting PPP1CA to the nucleolus. Taurus_UMD|evm.model.AC_000161.1.862 P50219 MNX1_HUMAN 83.333 0.955801 0.451372 MNX1 - Motor neuron and pancreas homeobox protein 1 - Homo sapiens (Human) - MNX1 gene Putative transcription factor involved in pancreas development and function. Taurus_UMD|evm.model.AC_000161.1.863 Q15386 UBE3C_HUMAN 91.889 0.998127 0.98615 UBE3C - Ubiquitin-protein ligase E3C - Homo sapiens (Human) - UBE3C gene E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. Taurus_UMD|evm.model.AC_000161.1.865 Q0III6 DNJB6_BOVIN 100.000 0.632877 1.50826 DNAJB6 - DnaJ homolog subfamily B member 6 - Bos taurus (Bovine) - DNAJB6 gene Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity). Taurus_UMD|evm.model.AC_000161.1.869 Q92932 PTPR2_HUMAN 54.593 0.962003 0.570443 PTPRN2 - Receptor-type tyrosine-protein phosphatase N2 precursor - Homo sapiens (Human) - PTPRN2 gene Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550). Taurus_UMD|evm.model.AC_000161.1.870 Q86XI2 CNDG2_HUMAN 81.190 0.998247 0.99825 NCAPG2 - Condensin-2 complex subunit G2 - Homo sapiens (Human) - NCAPG2 gene Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. Taurus_UMD|evm.model.AC_000161.1.871 Q3TZZ7 ESYT2_MOUSE 89.303 0.984597 0.998817 Esyt2 - Extended synaptotagmin-2 - Mus musculus (Mouse) - Esyt2 gene Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex (By similarity). Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (By similarity). Taurus_UMD|evm.model.AC_000161.1.872 Q8C761 DC2I1_MOUSE 65.818 0.995902 0.976977 Dync2i1 - Cytoplasmic dynein 2 intermediate chain 1 - Mus musculus (Mouse) - Dync2i1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I1 plays a major role in retrograde ciliary protein trafficking in cilia and flagella. Requires also to maintain a functional transition zone. Taurus_UMD|evm.model.AC_000161.1.873 P41587 VIPR2_HUMAN 86.957 0.984199 1.01142 VIPR2 - Vasoactive intestinal polypeptide receptor 2 precursor - Homo sapiens (Human) - VIPR2 gene This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. Taurus_UMD|evm.model.AC_000161.1.874 D6RJB6 U17LK_HUMAN 52.094 0.881517 0.796226 USP17L20 - Ubiquitin carboxyl-terminal hydrolase 17-like protein 20 - Homo sapiens (Human) - USP17L20 gene Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection. Taurus_UMD|evm.model.AC_000162.1.2 P60509 ERB1_HUMAN 32.787 0.947368 0.22179 ERVPABLB-1 - Endogenous retrovirus group PABLB member 1 Env polyprotein - Homo sapiens (Human) - ERVPABLB-1 gene Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. Taurus_UMD|evm.model.AC_000162.1.3 Q2T9M4 DRC7_BOVIN 92.453 0.684211 0.087156 DRC7 - Dynein regulatory complex subunit 7 - Bos taurus (Bovine) - DRC7 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility. Taurus_UMD|evm.model.AC_000162.1.4 Q9UPS8 ANR26_HUMAN 73.404 0.110583 0.491813 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000162.1.5 Q8IYA2 C144C_HUMAN 49.517 0.336088 0.880356 CCDC144CP - Putative coiled-coil domain-containing protein 144C - Homo sapiens (Human) - CCDC144CP gene Taurus_UMD|evm.model.AC_000162.1.6 Q9UPS8 ANR26_HUMAN 63.946 0.941725 0.250877 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000162.1.7 Q61086 FZD3_MOUSE 74.634 0.982249 0.253754 Fzd3 - Frizzled-3 precursor - Mus musculus (Mouse) - Fzd3 gene Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner. Taurus_UMD|evm.model.AC_000162.1.8 Q61086 FZD3_MOUSE 57.895 0.949495 0.148649 Fzd3 - Frizzled-3 precursor - Mus musculus (Mouse) - Fzd3 gene Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner. Taurus_UMD|evm.model.AC_000162.1.9 Q8IX29 FBX16_HUMAN 72.642 0.769517 0.921233 FBXO16 - F-box only protein 16 - Homo sapiens (Human) - FBXO16 gene Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Taurus_UMD|evm.model.AC_000162.1.10 Q2KIS9 TSN8_BOVIN 99.580 0.991632 1.0042 TSPAN8 - Tetraspanin-8 - Bos taurus (Bovine) - TSPAN8 gene integral component of plasma membrane Taurus_UMD|evm.model.AC_000162.1.11 F1MT22 LGR5_BOVIN 97.354 0.997738 0.974642 LGR5 - Leucine-rich repeat-containing G-protein coupled receptor 5 precursor - Bos taurus (Bovine) - LGR5 gene Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development (By similarity). Taurus_UMD|evm.model.AC_000162.1.12 O60293 ZC3H1_HUMAN 95.123 0.998994 1 ZFC3H1 - Zinc finger C3H1 domain-containing protein - Homo sapiens (Human) - ZFC3H1 gene Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. Taurus_UMD|evm.model.AC_000162.1.13 Q9H0W7 THAP2_HUMAN 93.396 0.954751 0.969298 THAP2 - THAP domain-containing protein 2 - Homo sapiens (Human) - THAP2 gene nucleolus, nucleus Taurus_UMD|evm.model.AC_000162.1.14 Q5RF73 TMM19_PONAB 88.955 0.991098 1.00298 TMEM19 - Transmembrane protein 19 - Pongo abelii (Sumatran orangutan) - TMEM19 gene Taurus_UMD|evm.model.AC_000162.1.15 Q17R06 RAB21_BOVIN 96.815 0.917647 0.765766 RAB21 - Ras-related protein Rab-21 precursor - Bos taurus (Bovine) - RAB21 gene Small GTPase involved in membrane trafficking control (By similarity). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (By similarity). Taurus_UMD|evm.model.AC_000162.1.16 Q8TC07 TBC15_HUMAN 94.790 0.99711 1.00145 TBC1D15 - TBC1 domain family member 15 - Homo sapiens (Human) - TBC1D15 gene Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity). Taurus_UMD|evm.model.AC_000162.1.17 Q2HZ26 TPH2_MACMU 87.460 0.993174 0.597959 TPH2 - Tryptophan 5-hydroxylase 2 - Macaca mulatta (Rhesus macaque) - TPH2 gene neuron projection, tryptophan 5-monooxygenase activity Taurus_UMD|evm.model.AC_000162.1.18 Q8IWU9 TPH2_HUMAN 97.826 0.73262 0.381633 TPH2 - Tryptophan 5-hydroxylase 2 - Homo sapiens (Human) - TPH2 gene cytosol, neuron projection, tryptophan 5-monooxygenase activity, indolalkylamine biosynthetic process Taurus_UMD|evm.model.AC_000162.1.20 Q9UKU6 TRHDE_HUMAN 90.935 0.789238 0.435547 TRHDE - Thyrotropin-releasing hormone-degrading ectoenzyme - Homo sapiens (Human) - TRHDE gene Specific inactivation of TRH after its release. Taurus_UMD|evm.model.AC_000162.1.21 Q9UKU6 TRHDE_HUMAN 98.257 0.961774 0.638672 TRHDE - Thyrotropin-releasing hormone-degrading ectoenzyme - Homo sapiens (Human) - TRHDE gene Specific inactivation of TRH after its release. Taurus_UMD|evm.model.AC_000162.1.22 Q96GX2 A7L3B_HUMAN 97.938 0.979592 1.01031 ATXN7L3B - Ataxin-7-like protein 3B - Homo sapiens (Human) - ATXN7L3B gene By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3. Taurus_UMD|evm.model.AC_000162.1.23 Q5JST6 EFHC2_HUMAN 72.194 0.979899 0.531375 EFHC2 - EF-hand domain-containing family member C2 - Homo sapiens (Human) - EFHC2 gene axoneme, ciliary basal body, mitotic spindle, alpha-tubulin binding, cilium-dependent cell motility, mitotic cytokinesis, mitotic spindle organization, regulation of neuron projection development Taurus_UMD|evm.model.AC_000162.1.24 Q96PR1 KCNC2_HUMAN 96.837 0.938215 0.684953 KCNC2 - Potassium voltage-gated channel subfamily C member 2 - Homo sapiens (Human) - KCNC2 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:15709110). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed:15709110). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000162.1.25 Q9GKR6 CAYP2_MACFA 80.831 0.505691 1.96486 CAPS2 - Calcyphosin-2 - Macaca fascicularis (Crab-eating macaque) - CAPS2 gene Taurus_UMD|evm.model.AC_000162.1.26 Q32LB5 GPRL1_BOVIN 100.000 0.991736 1.00415 GLIPR1L1 - GLIPR1-like protein 1 precursor - Bos taurus (Bovine) - GLIPR1L1 gene Plays a role in the binding between sperm and oocytes (PubMed:22552861). Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation (PubMed:23785420). Also component of the CD9-positive microvesicules found in the cauda region (PubMed:23785420). Taurus_UMD|evm.model.AC_000162.1.27 Q4G1C9 GRPL2_HUMAN 71.930 0.68997 0.956395 GLIPR1L2 - GLIPR1-like protein 2 - Homo sapiens (Human) - GLIPR1L2 gene extracellular space, binding of sperm to zona pellucida Taurus_UMD|evm.model.AC_000162.1.28 P48060 GLIP1_HUMAN 79.286 0.668269 0.781955 GLIPR1 - Glioma pathogenesis-related protein 1 precursor - Homo sapiens (Human) - GLIPR1 gene azurophil granule membrane, extracellular space, membrane, plasma membrane, neutrophil degranulation, regulation of metabolic process Taurus_UMD|evm.model.AC_000162.1.29 Q3B7L9 KRR1_BOVIN 100.000 0.994778 1.00262 KRR1 - KRR1 small subunit processome component homolog - Bos taurus (Bovine) - KRR1 gene Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). Taurus_UMD|evm.model.AC_000162.1.31 Q8WV24 PHLA1_HUMAN 90.970 0.744949 0.987531 PHLDA1 - Pleckstrin homology-like domain family A member 1 - Homo sapiens (Human) - PHLDA1 gene Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation. Taurus_UMD|evm.model.AC_000162.1.32 A6H767 NP1L1_BOVIN 100.000 0.994898 1.00256 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Taurus_UMD|evm.model.AC_000162.1.33 Q8TAM1 BBS10_HUMAN 79.412 0.169192 0.547718 BBS10 - Bardet-Biedl syndrome 10 protein - Homo sapiens (Human) - BBS10 gene Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (PubMed:20080638). Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). Involved in adipogenic differentiation (PubMed:19190184). Taurus_UMD|evm.model.AC_000162.1.34 Q9BZF1 OSBL8_HUMAN 95.565 0.997785 1.01575 OSBPL8 - Oxysterol-binding protein-related protein 8 - Homo sapiens (Human) - OSBPL8 gene Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). Taurus_UMD|evm.model.AC_000162.1.35 Q8IUH5 ZDH17_HUMAN 97.152 0.996785 0.984177 ZDHHC17 - Palmitoyltransferase ZDHHC17 - Homo sapiens (Human) - ZDHHC17 gene Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145). Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 (PubMed:24705354). Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade (By similarity). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg(2+) transport (PubMed:18794299). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Taurus_UMD|evm.model.AC_000162.1.36 Q16527 CSRP2_HUMAN 100.000 0.989691 1.00518 CSRP2 - Cysteine and glycine-rich protein 2 - Homo sapiens (Human) - CSRP2 gene Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system. Taurus_UMD|evm.model.AC_000162.1.37 E1BE02 E2F7_BOVIN 99.780 0.997802 0.998902 E2F7 - Transcription factor E2F7 - Bos taurus (Bovine) - E2F7 gene Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation (By similarity). Taurus_UMD|evm.model.AC_000162.1.39 Q8IVL0 NAV3_HUMAN 94.105 0.98062 0.973585 NAV3 - Neuron navigator 3 - Homo sapiens (Human) - NAV3 gene May regulate IL2 production by T-cells. May be involved in neuron regeneration. Taurus_UMD|evm.model.AC_000162.1.40 Q0V8N6 P3_BOVIN 96.479 0.859756 0.343816 SLC10A3 - P3 protein - Bos taurus (Bovine) - SLC10A3 gene The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions. Taurus_UMD|evm.model.AC_000162.1.41 P48018 SYT1_BOVIN 100.000 0.715986 1.39336 SYT1 - Synaptotagmin-1 - Bos taurus (Bovine) - SYT1 gene Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (By similarity). Taurus_UMD|evm.model.AC_000162.1.42 Q96IZ0 PAWR_HUMAN 92.982 0.977011 0.511765 PAWR - PRKC apoptosis WT1 regulator protein - Homo sapiens (Human) - PAWR gene Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. Taurus_UMD|evm.model.AC_000162.1.43 O14974 MYPT1_HUMAN 95.441 0.941011 1.03689 PPP1R12A - Protein phosphatase 1 regulatory subunit 12A - Homo sapiens (Human) - PPP1R12A gene Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. Taurus_UMD|evm.model.AC_000162.1.44 Q3ZCN5 OTOGL_HUMAN 89.996 0.977966 1.01201 OTOGL - Otogelin-like protein precursor - Homo sapiens (Human) - OTOGL gene extracellular matrix, extracellular space Taurus_UMD|evm.model.AC_000162.1.45 Q8IXK0 PHC2_HUMAN 87.179 0.67128 0.33683 PHC2 - Polyhomeotic-like protein 2 - Homo sapiens (Human) - PHC2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Taurus_UMD|evm.model.AC_000162.1.46 O15480 MAGB3_HUMAN 69.697 0.692308 0.676301 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Taurus_UMD|evm.model.AC_000162.1.47 O15480 MAGB3_HUMAN 44.944 0.838095 0.303468 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Taurus_UMD|evm.model.AC_000162.1.48 Q9UMZ3 PTPRQ_HUMAN 88.608 0.812235 1.21269 PTPRQ - Phosphatidylinositol phosphatase PTPRQ precursor - Homo sapiens (Human) - PTPRQ gene Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells. Taurus_UMD|evm.model.AC_000162.1.49 Q7YS80 MYF6_BOVIN 100.000 0.99177 1.00413 MYF6 - Myogenic factor 6 - Bos taurus (Bovine) - MYF6 gene Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). Taurus_UMD|evm.model.AC_000162.1.50 P17667 MYF5_BOVIN 100.000 0.992188 1.00392 MYF5 - Myogenic factor 5 - Bos taurus (Bovine) - MYF5 gene Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). Taurus_UMD|evm.model.AC_000162.1.51 O14910 LIN7A_HUMAN 100.000 0.991453 1.00429 LIN7A - Protein lin-7 homolog A - Homo sapiens (Human) - LIN7A gene Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Taurus_UMD|evm.model.AC_000162.1.52 A7MB45 ACSS3_BOVIN 99.825 0.998252 0.833819 ACSS3 - Acyl-CoA synthetase short-chain family member 3, mitochondrial precursor - Bos taurus (Bovine) - ACSS3 gene Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (By similarity). Propionate is the preferred substrate but can also utilize acetate and butyrate with a much lower affinity. Taurus_UMD|evm.model.AC_000162.1.53 O75334 LIPA2_HUMAN 98.298 0.991554 0.941925 PPFIA2 - Liprin-alpha-2 - Homo sapiens (Human) - PPFIA2 gene Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165). Taurus_UMD|evm.model.AC_000162.1.54 Q8BSS9 LIPA2_MOUSE 97.115 0.741007 0.110581 Ppfia2 - Liprin-alpha-2 - Mus musculus (Mouse) - Ppfia2 gene Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines. Taurus_UMD|evm.model.AC_000162.1.55 A5PJN1 TAP26_BOVIN 100.000 0.991736 1.00415 CCDC59 - Thyroid transcription factor 1-associated protein 26 - Bos taurus (Bovine) - CCDC59 gene Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities (By similarity). Taurus_UMD|evm.model.AC_000162.1.56 Q8N6Q8 MET25_HUMAN 92.727 0.222449 0.812604 METTL25 - Methyltransferase-like protein 25 - Homo sapiens (Human) - METTL25 gene Putative methyltransferase. Taurus_UMD|evm.model.AC_000162.1.57 Q8N394 TMTC2_HUMAN 96.139 0.920522 1.00837 TMTC2 - Protein O-mannosyl-transferase TMTC2 - Homo sapiens (Human) - TMTC2 gene Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Taurus_UMD|evm.model.AC_000162.1.58 Q2KIT1 PKRI1_BOVIN 97.006 0.78673 1.13441 PRKRIP1 - PRKR-interacting protein 1 - Bos taurus (Bovine) - PRKRIP1 gene Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity). Taurus_UMD|evm.model.AC_000162.1.59 Q03274 PO22_POPJA 31.200 0.56422 0.30661 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 - Popillia japonica (Japanese beetle) Taurus_UMD|evm.model.AC_000162.1.60 Q10126 YSM6_CAEEL 26.667 0.81068 0.738351 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000162.1.61 Q8IZY2 ABCA7_HUMAN 72.881 0.72 0.0349487 ABCA7 - Phospholipid-transporting ATPase ABCA7 - Homo sapiens (Human) - ABCA7 gene Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791). Taurus_UMD|evm.model.AC_000162.1.62 Q9XS59 S6A15_BOVIN 100.000 0.99726 1.00137 SLC6A15 - Sodium-dependent neutral amino acid transporter B(0)AT2 - Bos taurus (Bovine) - SLC6A15 gene Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for methionine and for the branched-chain amino acids, particularly leucine, valine and isoleucine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. Taurus_UMD|evm.model.AC_000162.1.63 P0C672 TSN19_HUMAN 74.494 0.987952 1.00403 TSPAN19 - Tetraspanin-19 - Homo sapiens (Human) - TSPAN19 gene integral component of plasma membrane Taurus_UMD|evm.model.AC_000162.1.64 Q96JM4 LRIQ1_HUMAN 69.041 0.445946 0.902439 LRRIQ1 - Leucine-rich repeat and IQ domain-containing protein 1 - Homo sapiens (Human) - LRRIQ1 gene Taurus_UMD|evm.model.AC_000162.1.66 Q15699 ALX1_HUMAN 98.466 0.993884 1.00307 ALX1 - ALX homeobox protein 1 - Homo sapiens (Human) - ALX1 gene Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:9753625, PubMed:8756334). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509). Taurus_UMD|evm.model.AC_000162.1.68 O75901 RASF9_HUMAN 92.184 0.995413 1.0023 RASSF9 - Ras association domain-containing protein 9 - Homo sapiens (Human) - RASSF9 gene May play a role in regulating vesicuar trafficking in cells. Taurus_UMD|evm.model.AC_000162.1.69 P01156 NEUT_BOVIN 100.000 0.988304 1.00588 NTS - Neurotensin/neuromedin N precursor - Bos taurus (Bovine) - NTS gene Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle. Taurus_UMD|evm.model.AC_000162.1.70 Q9UJQ4 SALL4_HUMAN 48.148 0.608 0.118708 SALL4 - Sal-like protein 4 - Homo sapiens (Human) - SALL4 gene Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells. Taurus_UMD|evm.model.AC_000162.1.71 Q6ITT3 MGT4C_PIG 91.841 0.995825 1.00209 MGAT4C - Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C - Sus scrofa (Pig) - MGAT4C gene Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity). Taurus_UMD|evm.model.AC_000162.1.72 P62755 RS6_RAT 67.464 0.959064 0.686747 Rps6 - 40S ribosomal protein S6 - Rattus norvegicus (Rat) - Rps6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Taurus_UMD|evm.model.AC_000162.1.73 Q32L99 PTGR2_BOVIN 96.392 0.989691 0.552707 PTGR2 - Prostaglandin reductase 2 - Bos taurus (Bovine) - PTGR2 gene Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Taurus_UMD|evm.model.AC_000162.1.74 Q32KY7 CL050_BOVIN 86.543 0.899582 1.27467 Uncharacterized protein C12orf50 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.75 Q2KJ69 CL029_BOVIN 100.000 0.993865 1.00308 Uncharacterized protein C12orf29 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.76 Q9TU23 CE290_BOVIN 99.847 0.528698 1.68529 CEP290 - Centrosomal protein of 290 kDa - Bos taurus (Bovine) - CEP290 gene Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes. Required for efficient recruitment of RAB8A to primary cilium. In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5. Activates ATF4-mediated transcription. Taurus_UMD|evm.model.AC_000162.1.79 Q6ZXV5 TMTC3_HUMAN 93.122 0.994559 1.00437 TMTC3 - Protein O-mannosyl-transferase TMTC3 - Homo sapiens (Human) - TMTC3 gene Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3 (PubMed:28973932). Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response. Taurus_UMD|evm.model.AC_000162.1.80 Q28132 SCF_BOVIN 100.000 0.992727 1.00365 KITLG - Kit ligand precursor - Bos taurus (Bovine) - KITLG gene Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity). Taurus_UMD|evm.model.AC_000162.1.85 A5GFQ0 RL7L_PIG 73.973 0.986301 0.295547 RPL7L1 - 60S ribosomal protein L7-like 1 - Sus scrofa (Pig) - RPL7L1 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000162.1.86 A5GFQ0 RL7L_PIG 45.946 0.980952 0.425101 RPL7L1 - 60S ribosomal protein L7-like 1 - Sus scrofa (Pig) - RPL7L1 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000162.1.87 Q2KJ36 DUS6_BOVIN 100.000 0.994764 1.00262 DUSP6 - Dual specificity protein phosphatase 6 - Bos taurus (Bovine) - DUSP6 gene Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Taurus_UMD|evm.model.AC_000162.1.90 Q8TC44 POC1B_HUMAN 89.727 0.993737 1.00209 POC1B - POC1 centriolar protein homolog B - Homo sapiens (Human) - POC1B gene Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567, PubMed:32060285). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation (PubMed:32060285). Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745). Taurus_UMD|evm.model.AC_000162.1.91 P23220 AT2B1_PIG 99.262 0.998362 1.00082 ATP2B1 - Plasma membrane calcium-transporting ATPase 1 - Sus scrofa (Pig) - ATP2B1 gene Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (By similarity). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles. Taurus_UMD|evm.model.AC_000162.1.93 Q2T9P9 CCER1_BOVIN 100.000 0.995192 1.00241 CCER1 - Coiled-coil domain-containing glutamate-rich protein 1 - Bos taurus (Bovine) - CCER1 gene Taurus_UMD|evm.model.AC_000162.1.94 P79119 EPYC_BOVIN 100.000 0.993789 1.00312 EPYC - Epiphycan precursor - Bos taurus (Bovine) - EPYC gene May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization. Taurus_UMD|evm.model.AC_000162.1.95 O62702 KERA_BOVIN 99.367 0.993691 0.900568 KERA - Keratocan precursor - Bos taurus (Bovine) - KERA gene May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. Taurus_UMD|evm.model.AC_000162.1.96 Q05443 LUM_BOVIN 100.000 0.994169 1.00292 LUM - Lumican precursor - Bos taurus (Bovine) - LUM gene extracellular matrix, extracellular space, collagen binding Taurus_UMD|evm.model.AC_000162.1.97 P21793 PGS2_BOVIN 100.000 0.99446 1.00278 DCN - Decorin precursor - Bos taurus (Bovine) - DCN gene May affect the rate of fibrils formation. Taurus_UMD|evm.model.AC_000162.1.98 Q6ZWQ7 SPCS3_MOUSE 95.652 0.865385 0.288889 Spcs3 - Signal peptidase complex subunit 3 - Mus musculus (Mouse) - Spcs3 gene Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Taurus_UMD|evm.model.AC_000162.1.99 P53348 BTG1_BOVIN 100.000 0.988372 1.00585 BTG1 - Protein BTG1 - Bos taurus (Bovine) - BTG1 gene Anti-proliferative protein. Taurus_UMD|evm.model.AC_000162.1.100 Q5RCP8 H2B2E_PONAB 90.476 0.984252 1.00794 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000162.1.101 Q8BHN1 TXLNG_MOUSE 79.221 0.690909 0.209924 Txlng - Gamma-taxilin - Mus musculus (Mouse) - Txlng gene May be involved in intracellular vesicle traffic (By similarity). Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. Taurus_UMD|evm.model.AC_000162.1.103 Q6ZR37 PKHG7_HUMAN 88.127 0.548621 1.81794 PLEKHG7 - Pleckstrin homology domain-containing family G member 7 - Homo sapiens (Human) - PLEKHG7 gene Rho protein signal transduction Taurus_UMD|evm.model.AC_000162.1.104 Q15075 EEA1_HUMAN 91.566 0.998583 1 EEA1 - Early endosome antigen 1 - Homo sapiens (Human) - EEA1 gene Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. Taurus_UMD|evm.model.AC_000162.1.105 A0A024RBG1 NUD4B_HUMAN 97.238 0.989011 1.00552 NUDT4B - Diphosphoinositol polyphosphate phosphohydrolase NUDT4B - Homo sapiens (Human) - NUDT4B gene Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. Taurus_UMD|evm.model.AC_000162.1.106 Q5R7J6 UBE2N_PONAB 100.000 0.92 0.986842 UBE2N - Ubiquitin-conjugating enzyme E2 N - Pongo abelii (Sumatran orangutan) - UBE2N gene The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. Taurus_UMD|evm.model.AC_000162.1.108 P82927 RM42_BOVIN 100.000 0.986014 1.00704 MRPL42 - 39S ribosomal protein L42, mitochondrial precursor - Bos taurus (Bovine) - MRPL42 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Taurus_UMD|evm.model.AC_000162.1.109 Q861R0 SOCS2_BOVIN 100.000 0.98995 1.00505 SOCS2 - Suppressor of cytokine signaling 2 - Bos taurus (Bovine) - SOCS2 gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Taurus_UMD|evm.model.AC_000162.1.110 O88843 CRADD_MOUSE 88.442 0.887892 1.1206 Cradd - Death domain-containing protein CRADD - Mus musculus (Mouse) - Cradd gene Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway. Taurus_UMD|evm.model.AC_000162.1.111 O60486 PLXC1_HUMAN 88.261 0.998731 1.0051 PLXNC1 - Plexin-C1 precursor - Homo sapiens (Human) - PLXNC1 gene Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity). Taurus_UMD|evm.model.AC_000162.1.112 Q9Y592 CEP83_HUMAN 87.161 0.997147 1 CEP83 - Centrosomal protein of 83 kDa - Homo sapiens (Human) - CEP83 gene Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly. Taurus_UMD|evm.model.AC_000162.1.114 Q9ULS5 TMCC3_HUMAN 93.082 0.995816 1.0021 TMCC3 - Transmembrane and coiled-coil domain protein 3 - Homo sapiens (Human) - TMCC3 gene endomembrane system, endoplasmic reticulum, 14-3-3 protein binding, identical protein binding Taurus_UMD|evm.model.AC_000162.1.115 O97725 NDUAC_BOVIN 80.000 0.983051 0.813793 NDUFA12 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 - Bos taurus (Bovine) - NDUFA12 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000162.1.116 A0JNE3 NR2C1_BOVIN 99.836 0.996716 1.00164 NR2C1 - Nuclear receptor subfamily 2 group C member 1 - Bos taurus (Bovine) - NR2C1 gene Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity). Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity). Taurus_UMD|evm.model.AC_000162.1.117 Q6ZV73 FGD6_HUMAN 83.554 0.998606 1.0035 FGD6 - FYVE, RhoGEF and PH domain-containing protein 6 - Homo sapiens (Human) - FGD6 gene May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). Taurus_UMD|evm.model.AC_000162.1.118 Q9HBM0 VEZA_HUMAN 88.932 0.928224 1.0552 VEZT - Vezatin - Homo sapiens (Human) - VEZT gene Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. Taurus_UMD|evm.model.AC_000162.1.119 Q8CDN1 CC020_MOUSE 25.678 0.962343 0.512326 Uncharacterized protein C3orf20 homolog - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000162.1.121 Q3ZC89 MAP2_BOVIN 99.790 0.995816 1.0021 METAP2 - Methionine aminopeptidase 2 - Bos taurus (Bovine) - METAP2 gene Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Taurus_UMD|evm.model.AC_000162.1.122 D2HBJ8 UBP44_AILME 92.275 0.997183 0.998594 USP44 - Ubiquitin carboxyl-terminal hydrolase 44 - Ailuropoda melanoleuca (Giant panda) - USP44 gene Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination (By similarity). Taurus_UMD|evm.model.AC_000162.1.123 Q29407 MEA1_BOVIN 97.126 0.988571 1.00575 MEA1 - Male-enhanced antigen 1 - Bos taurus (Bovine) - MEA1 gene May play an important role in spermatogenesis and/or testis development. Taurus_UMD|evm.model.AC_000162.1.125 Q9UKY7 CDV3_HUMAN 88.776 0.969697 0.383721 CDV3 - Protein CDV3 homolog - Homo sapiens (Human) - CDV3 gene cytoplasm, cytosol, plasma membrane Taurus_UMD|evm.model.AC_000162.1.128 P80195 GLCM1_BOVIN 100.000 0.987013 1.00654 GLYCAM1 - Glycosylation-dependent cell adhesion molecule 1 precursor - Bos taurus (Bovine) - GLYCAM1 gene identical protein binding Taurus_UMD|evm.model.AC_000162.1.129 P19103 PPR1A_RAT 82.677 0.875 0.842105 Ppp1r1a - Protein phosphatase 1 regulatory subunit 1A - Rattus norvegicus (Rat) - Ppp1r1a gene Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. Taurus_UMD|evm.model.AC_000162.1.130 Q01061 PDE1B_BOVIN 99.439 0.996269 1.00375 PDE1B - Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B - Bos taurus (Bovine) - PDE1B gene Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate (By similarity). Taurus_UMD|evm.model.AC_000162.1.131 P55160 NCKPL_HUMAN 94.854 0.99207 1.0071 NCKAP1L - Nck-associated protein 1-like - Homo sapiens (Human) - NCKAP1L gene Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells (PubMed:32647003). Required for efficient T-lymphocyte and neutrophil migration (PubMed:32647003). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed:16417406). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed:17696648). In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF (PubMed:32647003). Taurus_UMD|evm.model.AC_000162.1.132 Q3SZU0 GTSF1_BOVIN 100.000 0.761468 1.30539 GTSF1 - Gametocyte-specific factor 1 - Bos taurus (Bovine) - GTSF1 gene Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells. Taurus_UMD|evm.model.AC_000162.1.133 P08648 ITA5_HUMAN 92.512 0.998106 1.00667 ITGA5 - Integrin alpha-5 precursor - Homo sapiens (Human) - ITGA5 gene Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). Taurus_UMD|evm.model.AC_000162.1.134 Q96PM9 Z385A_HUMAN 97.409 0.994832 1.00259 ZNF385A - Zinc finger protein 385A - Homo sapiens (Human) - ZNF385A gene RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. Taurus_UMD|evm.model.AC_000162.1.135 Q2KI97 GPR84_BOVIN 100.000 0.994962 1.00253 GPR84 - G-protein coupled receptor 84 - Bos taurus (Bovine) - GPR84 gene Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system (By similarity). Taurus_UMD|evm.model.AC_000162.1.136 P35604 COPZ1_BOVIN 100.000 0.988764 1.00565 COPZ1 - Coatomer subunit zeta-1 - Bos taurus (Bovine) - COPZ1 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity). Taurus_UMD|evm.model.AC_000162.1.137 Q3SZA5 SPSY_BOVIN 98.276 0.991416 0.638356 SMS - Spermine synthase - Bos taurus (Bovine) - SMS gene Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). Taurus_UMD|evm.model.AC_000162.1.138 Q5EAD3 NFE2_BOVIN 100.000 0.715931 1.39305 NFE2 - Transcription factor NF-E2 45 kDa subunit - Bos taurus (Bovine) - NFE2 gene Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (By similarity). Taurus_UMD|evm.model.AC_000162.1.139 P09651 ROA1_HUMAN 99.732 0.994652 1.00538 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Homo sapiens (Human) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). Taurus_UMD|evm.model.AC_000162.1.140 P45973 CBX5_HUMAN 100.000 0.989583 1.00524 CBX5 - Chromobox protein homolog 5 - Homo sapiens (Human) - CBX5 gene Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Taurus_UMD|evm.model.AC_000162.1.141 Q59I47 SMUG1_BOVIN 100.000 0.992674 1.00368 SMUG1 - Single-strand selective monofunctional uracil DNA glycosylase - Bos taurus (Bovine) - SMUG1 gene Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration. Taurus_UMD|evm.model.AC_000162.1.142 P09017 HXC4_HUMAN 99.621 0.992453 1.00379 HOXC4 - Homeobox protein Hox-C4 - Homo sapiens (Human) - HOXC4 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000162.1.143 P32043 HXC5_MOUSE 99.550 0.991031 1.0045 Hoxc5 - Homeobox protein Hox-C5 - Mus musculus (Mouse) - Hoxc5 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000162.1.144 P49925 HXC6_SHEEP 100.000 0.655172 1.51634 HOXC6 - Homeobox protein Hox-C6 - Ovis aries (Sheep) - HOXC6 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000162.1.145 P09025 HXC8_MOUSE 100.000 0.99177 1.00413 Hoxc8 - Homeobox protein Hox-C8 - Mus musculus (Mouse) - Hoxc8 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000162.1.146 P09633 HXC9_MOUSE 100.000 0.992337 1.00385 Hoxc9 - Homeobox protein Hox-C9 - Mus musculus (Mouse) - Hoxc9 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000162.1.147 Q9NYD6 HXC10_HUMAN 97.388 0.491713 1.58772 HOXC10 - Homeobox protein Hox-C10 - Homo sapiens (Human) - HOXC10 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000162.1.148 P31275 HXC12_HUMAN 96.479 0.992908 1 HOXC12 - Homeobox protein Hox-C12 - Homo sapiens (Human) - HOXC12 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000162.1.149 P31276 HXC13_HUMAN 98.905 0.992727 0.833333 HOXC13 - Homeobox protein Hox-C13 - Homo sapiens (Human) - HOXC13 gene Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity). Taurus_UMD|evm.model.AC_000162.1.151 Q2KJ21 CACO1_BOVIN 97.230 0.988456 1.01912 CALCOCO1 - Calcium-binding and coiled-coil domain-containing protein 1 - Bos taurus (Bovine) - CALCOCO1 gene Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (By similarity). Taurus_UMD|evm.model.AC_000162.1.152 P84100 RL19_RAT 89.474 0.397849 0.47449 Rpl19 - 60S ribosomal protein L19 - Rattus norvegicus (Rat) - Rpl19 gene cytosolic large ribosomal subunit, polysomal ribosome, synapse, 5.8S rRNA binding, large ribosomal subunit rRNA binding, RNA binding, structural constituent of ribosome, cytoplasmic translation, liver regeneration Taurus_UMD|evm.model.AC_000162.1.153 P07926 AT5G2_BOVIN 100.000 0.986111 1.00699 ATP5MC2 - ATP synthase F(0) complex subunit C2, mitochondrial precursor - Bos taurus (Bovine) - ATP5MC2 gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element. Taurus_UMD|evm.model.AC_000162.1.154 P17544 ATF7_HUMAN 98.344 0.995868 1.00207 ATF7 - Cyclic AMP-dependent transcription factor ATF-7 - Homo sapiens (Human) - ATF7 gene Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation (PubMed:29490055). In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes (By similarity). Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation (By similarity). In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening (PubMed:29490055). Plays also a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (By similarity). Taurus_UMD|evm.model.AC_000162.1.155 Q0IIG6 TRBP2_BOVIN 100.000 0.755694 1.31967 TARBP2 - RISC-loading complex subunit TARBP2 - Bos taurus (Bovine) - TARBP2 gene Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Taurus_UMD|evm.model.AC_000162.1.156 Q60700 M3K12_MOUSE 95.969 0.997763 1.00676 Map3k12 - Mitogen-activated protein kinase kinase kinase 12 - Mus musculus (Mouse) - Map3k12 gene Protein kinase which is part of a non-canonical MAPK signaling pathway (PubMed:7983011, PubMed:8663324, PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. Taurus_UMD|evm.model.AC_000162.1.157 Q61990 PCBP2_MOUSE 100.000 0.99449 1.00276 Pcbp2 - Poly(rC)-binding protein 2 - Mus musculus (Mouse) - Pcbp2 gene Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation (By similarity). Taurus_UMD|evm.model.AC_000162.1.158 Q9NZ81 PRR13_HUMAN 81.132 0.739437 0.959459 PRR13 - Proline-rich protein 13 - Homo sapiens (Human) - PRR13 gene Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis. Taurus_UMD|evm.model.AC_000162.1.159 Q28616 AMHR2_RABIT 85.385 0.950459 0.957821 AMHR2 - Anti-Muellerian hormone type-2 receptor precursor - Oryctolagus cuniculus (Rabbit) - AMHR2 gene On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Taurus_UMD|evm.model.AC_000162.1.160 P08047 SP1_HUMAN 96.662 0.997436 0.993631 SP1 - Transcription factor Sp1 - Homo sapiens (Human) - SP1 gene Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21798247, PubMed:21046154). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). Taurus_UMD|evm.model.AC_000162.1.161 Q8TDD2 SP7_HUMAN 96.984 0.879346 1.13457 SP7 - Transcription factor Sp7 - Homo sapiens (Human) - SP7 gene Transcriptional activator essential for osteoblast differentiation (PubMed:23457570). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity). Taurus_UMD|evm.model.AC_000162.1.162 Q9NRG9 AAAS_HUMAN 95.971 0.994526 1.00366 AAAS - Aladin - Homo sapiens (Human) - AAAS gene Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285). Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606). Taurus_UMD|evm.model.AC_000162.1.163 Q58DG1 MYG1_BOVIN 100.000 0.994764 1.00262 MYG1 - MYG1 exonuclease precursor - Bos taurus (Bovine) - MYG1 gene 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk. In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins. Taurus_UMD|evm.model.AC_000162.1.164 Q8HYI9 PFD5_BOVIN 100.000 0.987097 1.00649 PFDN5 - Prefoldin subunit 5 - Bos taurus (Bovine) - PFDN5 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC (By similarity). Taurus_UMD|evm.model.AC_000162.1.165 Q14674 ESPL1_HUMAN 83.561 0.994787 0.995283 ESPL1 - Separin - Homo sapiens (Human) - ESPL1 gene Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. Taurus_UMD|evm.model.AC_000162.1.166 Q0VC03 MFSD5_BOVIN 100.000 0.995565 1.00222 MFSD5 - Molybdate-anion transporter - Bos taurus (Bovine) - MFSD5 gene Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. Taurus_UMD|evm.model.AC_000162.1.167 P18911 RARG_MOUSE 99.095 0.348341 2.76419 Rarg - Retinoic acid receptor gamma - Mus musculus (Mouse) - Rarg gene Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function. Taurus_UMD|evm.model.AC_000162.1.168 Q8NDX6 ZN740_HUMAN 99.482 0.989691 1.00518 ZNF740 - Zinc finger protein 740 - Homo sapiens (Human) - ZNF740 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000162.1.169 Q9Y600 CSAD_HUMAN 90.669 0.940727 1.06085 CSAD - Cysteine sulfinic acid decarboxylase - Homo sapiens (Human) - CSAD gene Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3-sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate. Taurus_UMD|evm.model.AC_000162.1.170 O77759 SOAT2_CHLAE 87.607 0.675832 1.31369 SOAT2 - Sterol O-acyltransferase 2 - Chlorocebus aethiops (Green monkey) - SOAT2 gene Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa. Taurus_UMD|evm.model.AC_000162.1.171 Q8NCJ5 SPRY3_HUMAN 95.928 0.995327 0.968326 SPRYD3 - SPRY domain-containing protein 3 - Homo sapiens (Human) - SPRYD3 gene cytoplasm, cell surface receptor signaling pathway, cytoskeleton organization Taurus_UMD|evm.model.AC_000162.1.172 Q63HR2 TNS2_HUMAN 92.924 0.98156 1.00071 TNS2 - Tensin-2 - Homo sapiens (Human) - TNS2 gene Tyrosine-protein phosphatase which regulates cell motility proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856). Taurus_UMD|evm.model.AC_000162.1.173 P23588 IF4B_HUMAN 95.581 0.996727 1 EIF4B - Eukaryotic translation initiation factor 4B - Homo sapiens (Human) - EIF4B gene Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. Taurus_UMD|evm.model.AC_000162.1.174 P05783 K1C18_HUMAN 88.605 0.995349 1 KRT18 - Keratin, type I cytoskeletal 18 - Homo sapiens (Human) - KRT18 gene Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. Taurus_UMD|evm.model.AC_000162.1.175 P05786 K2C8_BOVIN 93.724 0.995556 0.941423 KRT8 - Keratin, type II cytoskeletal 8 - Bos taurus (Bovine) - KRT8 gene Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Taurus_UMD|evm.model.AC_000162.1.176 A6QNX5 K2C78_BOVIN 100.000 0.996219 1.00189 KRT78 - Keratin, type II cytoskeletal 78 - Bos taurus (Bovine) - KRT78 gene Taurus_UMD|evm.model.AC_000162.1.177 Q148H7 K2C79_BOVIN 100.000 0.996269 1.00187 KRT79 - Keratin, type II cytoskeletal 79 - Bos taurus (Bovine) - KRT79 gene Taurus_UMD|evm.model.AC_000162.1.178 P19013 K2C4_HUMAN 84.551 0.869091 1.05769 KRT4 - Keratin, type II cytoskeletal 4 - Homo sapiens (Human) - KRT4 gene cell surface, cytosol, intermediate filament, intermediate filament cytoskeleton, keratin filament, nucleus, cornification, cytoskeleton organization, epithelial cell differentiation, keratinization Taurus_UMD|evm.model.AC_000162.1.179 Q29426 K2C3_RABIT 91.143 0.548742 1.01113 KRT3 - Keratin, type II cytoskeletal 3 - Oryctolagus cuniculus (Rabbit) - KRT3 gene epithelial cell differentiation, intermediate filament cytoskeleton organization Taurus_UMD|evm.model.AC_000162.1.180 Q01546 K22O_HUMAN 82.873 0.603679 0.937304 KRT76 - Keratin, type II cytoskeletal 2 oral - Homo sapiens (Human) - KRT76 gene Probably contributes to terminal cornification. Taurus_UMD|evm.model.AC_000162.1.181 Q4V8C5 AR2BP_RAT 67.568 0.477124 0.93865 Arl2bp - ADP-ribosylation factor-like protein 2-binding protein - Rattus norvegicus (Rat) - Arl2bp gene Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity). Taurus_UMD|evm.model.AC_000162.1.182 Q7Z794 K2C1B_HUMAN 82.920 0.322351 1.94291 KRT77 - Keratin, type II cytoskeletal 1b - Homo sapiens (Human) - KRT77 gene cytoskeleton, cytosol, extracellular exosome, cornification, keratinization Taurus_UMD|evm.model.AC_000162.1.183 A5A6M6 K2C1_PANTR 83.521 0.726524 0.952904 KRT1 - Keratin, type II cytoskeletal 1 - Pan troglodytes (Chimpanzee) - KRT1 gene May regulate the activity of kinases such as PKC and SRC via binding to integrin beta 1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity). Taurus_UMD|evm.model.AC_000162.1.184 P35908 K22E_HUMAN 75.137 0.589661 0.968701 KRT2 - Keratin, type II cytoskeletal 2 epidermal - Homo sapiens (Human) - KRT2 gene Probably contributes to terminal cornification (PubMed:1380918). Associated with keratinocyte activation, proliferation and keratinization (PubMed:12598329). Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). Taurus_UMD|evm.model.AC_000162.1.185 A7YWK3 K2C73_BOVIN 100.000 0.996303 1.00185 KRT73 - Keratin, type II cytoskeletal 73 - Bos taurus (Bovine) - KRT73 gene Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity). Taurus_UMD|evm.model.AC_000162.1.186 Q148H8 K2C72_BOVIN 100.000 0.99619 1.00191 KRT72 - Keratin, type II cytoskeletal 72 - Bos taurus (Bovine) - KRT72 gene Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity). Taurus_UMD|evm.model.AC_000162.1.187 A3KN27 K2C74_BOVIN 97.455 0.996276 0.976364 KRT74 - Keratin, type II cytoskeletal 74 - Bos taurus (Bovine) - KRT74 gene Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity). Taurus_UMD|evm.model.AC_000162.1.188 Q148H5 K2C71_BOVIN 100.000 0.996198 1.0019 KRT71 - Keratin, type II cytoskeletal 71 - Bos taurus (Bovine) - KRT71 gene Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. Taurus_UMD|evm.model.AC_000162.1.189 Q5XQN5 K2C5_BOVIN 99.168 0.996656 0.995008 KRT5 - Keratin, type II cytoskeletal 5 - Bos taurus (Bovine) - KRT5 gene epithelial cell differentiation, negative regulation of epithelial cell proliferation Taurus_UMD|evm.model.AC_000162.1.190 P02538 K2C6A_HUMAN 87.174 0.870629 1.01418 KRT6A - Keratin, type II cytoskeletal 6A - Homo sapiens (Human) - KRT6A gene Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Taurus_UMD|evm.model.AC_000162.1.191 P02538 K2C6A_HUMAN 86.774 0.870629 1.01418 KRT6A - Keratin, type II cytoskeletal 6A - Homo sapiens (Human) - KRT6A gene Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Taurus_UMD|evm.model.AC_000162.1.192 P02538 K2C6A_HUMAN 87.174 0.870629 1.01418 KRT6A - Keratin, type II cytoskeletal 6A - Homo sapiens (Human) - KRT6A gene Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Taurus_UMD|evm.model.AC_000162.1.193 P02538 K2C6A_HUMAN 68.715 0.681992 0.462766 KRT6A - Keratin, type II cytoskeletal 6A - Homo sapiens (Human) - KRT6A gene Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Taurus_UMD|evm.model.AC_000162.1.194 Q08D91 K2C75_BOVIN 100.000 0.996324 1.00184 KRT75 - Keratin, type II cytoskeletal 75 - Bos taurus (Bovine) - KRT75 gene Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity). Taurus_UMD|evm.model.AC_000162.1.195 Q6P6Q2 K2C5_RAT 78.804 0.68609 0.923611 Krt5 - Keratin, type II cytoskeletal 5 - Rattus norvegicus (Rat) - Krt5 gene cytoplasm, intermediate filament, keratin filament, scaffold protein binding Taurus_UMD|evm.model.AC_000162.1.196 Q9NSB4 KRT82_HUMAN 82.330 0.994175 1.0039 KRT82 - Keratin, type II cuticular Hb2 - Homo sapiens (Human) - KRT82 gene cytosol, keratin filament, structural constituent of skin epidermis, cornification, keratinization Taurus_UMD|evm.model.AC_000162.1.197 Q9NSB2 KRT84_HUMAN 79.174 0.996633 0.99 KRT84 - Keratin, type II cuticular Hb4 - Homo sapiens (Human) - KRT84 gene cytosol, extracellular exosome, keratin filament, structural constituent of cytoskeleton, cornification, hair follicle development, keratinization, nail development Taurus_UMD|evm.model.AC_000162.1.198 P25691 K2M3_SHEEP 96.838 0.994094 1.01195 Keratin, type II microfibrillar, component 5 - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000162.1.199 P25691 K2M3_SHEEP 74.684 0.935223 0.984064 Keratin, type II microfibrillar, component 5 - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000162.1.200 A4FUZ0 KRT83_BOVIN 98.326 0.937132 1.03245 KRT83 - Keratin, type II cuticular Hb3 - Bos taurus (Bovine) - KRT83 gene Taurus_UMD|evm.model.AC_000162.1.201 Q148H4 KRT81_BOVIN 93.595 0.98768 0.974 KRT81 - Keratin, type II cuticular Hb1 - Bos taurus (Bovine) - KRT81 gene Taurus_UMD|evm.model.AC_000162.1.202 Q148H4 KRT81_BOVIN 100.000 0.996008 1.002 KRT81 - Keratin, type II cuticular Hb1 - Bos taurus (Bovine) - KRT81 gene Taurus_UMD|evm.model.AC_000162.1.203 P25691 K2M3_SHEEP 50.943 0.79397 0.396414 Keratin, type II microfibrillar, component 5 - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000162.1.204 A4FUZ0 KRT83_BOVIN 82.448 0.888199 0.979716 KRT83 - Keratin, type II cuticular Hb3 - Bos taurus (Bovine) - KRT83 gene Taurus_UMD|evm.model.AC_000162.1.205 Q148H4 KRT81_BOVIN 84.946 0.907298 1.014 KRT81 - Keratin, type II cuticular Hb1 - Bos taurus (Bovine) - KRT81 gene Taurus_UMD|evm.model.AC_000162.1.206 Q29S21 K2C7_BOVIN 100.000 0.995717 1.00215 KRT7 - Keratin, type II cytoskeletal 7 - Bos taurus (Bovine) - KRT7 gene Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Taurus_UMD|evm.model.AC_000162.1.207 A0JND2 K2C80_BOVIN 100.000 0.907285 1.07346 KRT80 - Keratin, type II cytoskeletal 80 - Bos taurus (Bovine) - KRT80 gene Taurus_UMD|evm.model.AC_000162.1.208 A0A2R8YCJ5 SIM41_HUMAN 81.111 0.967391 0.989247 SMIM41 - Small integral membrane protein 41 - Homo sapiens (Human) - SMIM41 gene Taurus_UMD|evm.model.AC_000162.1.209 Q2HJE0 ATGA1_BOVIN 100.000 0.990868 1.00459 ATG101 - Autophagy-related protein 101 - Bos taurus (Bovine) - ATG101 gene Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. Taurus_UMD|evm.model.AC_000162.1.210 Q0V8F0 NR4A1_BOVIN 100.000 0.796 1.25418 NR4A1 - Nuclear receptor subfamily 4 group A member 1 - Bos taurus (Bovine) - NR4A1 gene Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Plays a role in the vascular response to injury (By similarity). Taurus_UMD|evm.model.AC_000162.1.211 Q7Z6J2 GRASP_HUMAN 88.665 0.994937 1 TAMALIN - Protein TAMALIN - Homo sapiens (Human) - TAMALIN gene Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. Taurus_UMD|evm.model.AC_000162.1.212 P80202 ACV1B_RAT 99.406 0.996047 1.00198 Acvr1b - Activin receptor type-1B precursor - Rattus norvegicus (Rat) - Acvr1b gene Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2 (By similarity). Taurus_UMD|evm.model.AC_000162.1.213 P37023 ACVL1_HUMAN 90.656 0.994048 1.00199 ACVRL1 - Serine/threonine-protein kinase receptor R3 precursor - Homo sapiens (Human) - ACVRL1 gene Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. Taurus_UMD|evm.model.AC_000162.1.214 Q7Z3H0 PANKY_HUMAN 75.510 0.967337 0.880531 ANKRD33 - Photoreceptor ankyrin repeat protein - Homo sapiens (Human) - ANKRD33 gene Acts as a transcriptional repressor for CRX-activated photoreceptor gene regulation. Taurus_UMD|evm.model.AC_000162.1.215 A6NMB9 FIGL2_HUMAN 90.895 0.996956 1.00613 FIGNL2 - Fidgetin-like protein 2 - Homo sapiens (Human) - FIGNL2 gene nucleus, ATPase activity, microtubule-severing ATPase activity, cytoplasmic microtubule organization Taurus_UMD|evm.model.AC_000162.1.216 P0DPE3 TMDD1_HUMAN 68.771 0.99 0.946372 TMDD1 - Transmembrane and death domain protein 1 precursor - Homo sapiens (Human) - TMDD1 gene Taurus_UMD|evm.model.AC_000162.1.217 Q9UQD0 SCN8A_HUMAN 97.960 0.999005 1.01566 SCN8A - Sodium channel protein type 8 subunit alpha - Homo sapiens (Human) - SCN8A gene Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:29726066). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Taurus_UMD|evm.model.AC_000162.1.218 Q2Y0W8 S4A8_HUMAN 97.987 0.99817 1 SLC4A8 - Electroneutral sodium bicarbonate exchanger 1 - Homo sapiens (Human) - SLC4A8 gene Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. Taurus_UMD|evm.model.AC_000162.1.220 Q5EA41 GALT6_BOVIN 99.839 0.99679 1.00161 GALNT6 - Polypeptide N-acetylgalactosaminyltransferase 6 - Bos taurus (Bovine) - GALNT6 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides (By similarity). Taurus_UMD|evm.model.AC_000162.1.221 Q28153 CELA1_BOVIN 100.000 0.992509 1.00376 CELA1 - Chymotrypsin-like elastase family member 1 precursor - Bos taurus (Bovine) - CELA1 gene Acts upon elastin. Taurus_UMD|evm.model.AC_000162.1.222 Q5ZKL7 BIN2_CHICK 79.323 0.509615 1.09244 BIN2 - Bridging integrator 2 - Gallus gallus (Chicken) - BIN2 gene plasma membrane, podosome, phospholipid binding, phagocytosis, engulfment, plasma membrane tubulation, podosome assembly Taurus_UMD|evm.model.AC_000162.1.223 A4IFL2 SMAGP_BOVIN 100.000 0.979592 1.01031 SMAGP - Small cell adhesion glycoprotein - Bos taurus (Bovine) - SMAGP gene May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation (By similarity). Taurus_UMD|evm.model.AC_000162.1.224 Q5R526 DAZP2_PONAB 100.000 0.988166 1.00595 DAZAP2 - DAZ-associated protein 2 - Pongo abelii (Sumatran orangutan) - DAZAP2 gene Taurus_UMD|evm.model.AC_000162.1.225 Q14863 PO6F1_HUMAN 98.671 0.490196 2.03322 POU6F1 - POU domain, class 6, transcription factor 1 - Homo sapiens (Human) - POU6F1 gene Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3'). Taurus_UMD|evm.model.AC_000162.1.226 Q12800 TFCP2_HUMAN 99.402 0.996016 1 TFCP2 - Alpha-globin transcription factor CP2 - Homo sapiens (Human) - TFCP2 gene Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. Taurus_UMD|evm.model.AC_000162.1.227 Q9H175 CSRN2_HUMAN 99.265 0.668317 0.372007 CSRNP2 - Cysteine/serine-rich nuclear protein 2 - Homo sapiens (Human) - CSRNP2 gene Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis. Taurus_UMD|evm.model.AC_000162.1.228 A3KN46 LTMD1_BOVIN 99.722 0.99446 1.00278 LETMD1 - LETM1 domain-containing protein 1 - Bos taurus (Bovine) - LETMD1 gene May function as a negative regulator of the p53/TP53. Taurus_UMD|evm.model.AC_000162.1.229 Q9H175 CSRN2_HUMAN 91.892 0.990244 0.755064 CSRNP2 - Cysteine/serine-rich nuclear protein 2 - Homo sapiens (Human) - CSRNP2 gene Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis. Taurus_UMD|evm.model.AC_000162.1.230 P49281 NRAM2_HUMAN 93.322 0.859304 1.16373 SLC11A2 - Natural resistance-associated macrophage protein 2 - Homo sapiens (Human) - SLC11A2 gene Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria. Taurus_UMD|evm.model.AC_000162.1.231 Q9H8H3 MET7A_HUMAN 62.651 0.957447 0.577869 METTL7A - Methyltransferase-like protein 7A precursor - Homo sapiens (Human) - METTL7A gene Probable methyltransferase. Taurus_UMD|evm.model.AC_000162.1.232 O00370 LORF2_HUMAN 58.635 0.991667 0.188235 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000162.1.233 P49282 NRAM2_MOUSE 83.582 0.923744 1.01585 Slc11a2 - Natural resistance-associated macrophage protein 2 - Mus musculus (Mouse) - Slc11a2 gene May serve to import iron into the mitochondria (By similarity). Important in metal transport, in particular iron. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. Taurus_UMD|evm.model.AC_000162.1.234 Q9H8H3 MET7A_HUMAN 84.024 0.954545 0.721311 METTL7A - Methyltransferase-like protein 7A precursor - Homo sapiens (Human) - METTL7A gene Probable methyltransferase. Taurus_UMD|evm.model.AC_000162.1.235 P49282 NRAM2_MOUSE 86.372 0.855784 1.11092 Slc11a2 - Natural resistance-associated macrophage protein 2 - Mus musculus (Mouse) - Slc11a2 gene May serve to import iron into the mitochondria (By similarity). Important in metal transport, in particular iron. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. Taurus_UMD|evm.model.AC_000162.1.236 A8MV81 HIG1C_HUMAN 91.667 0.734513 1.16495 HIGD1C - HIG1 domain family member 1C - Homo sapiens (Human) - HIGD1C gene mitochondrion, mitochondrial respirasome assembly Taurus_UMD|evm.model.AC_000162.1.238 Q9H8H3 MET7A_HUMAN 86.475 0.991837 1.0041 METTL7A - Methyltransferase-like protein 7A precursor - Homo sapiens (Human) - METTL7A gene Probable methyltransferase. Taurus_UMD|evm.model.AC_000162.1.239 Q2TBH8 ZWINT_BOVIN 99.301 0.993031 1.0035 ZWINT - ZW10 interactor - Bos taurus (Bovine) - ZWINT gene Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity). Taurus_UMD|evm.model.AC_000162.1.240 Q86WS5 TMPSC_HUMAN 74.809 0.872483 0.428161 TMPRSS12 - Transmembrane protease serine 12 precursor - Homo sapiens (Human) - TMPRSS12 gene Taurus_UMD|evm.model.AC_000162.1.241 P24049 RL17_RAT 81.212 0.83871 1.01087 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000162.1.242 Q08DA8 ATF1_BOVIN 87.097 0.993569 1.15185 ATF1 - Cyclic AMP-dependent transcription factor ATF-1 - Bos taurus (Bovine) - ATF1 gene This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity). Taurus_UMD|evm.model.AC_000162.1.243 Q9P265 DIP2B_HUMAN 98.858 0.952208 1.04886 DIP2B - Disco-interacting protein 2 homolog B - Homo sapiens (Human) - DIP2B gene Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. Taurus_UMD|evm.model.AC_000162.1.244 Q71RC2 LARP4_HUMAN 89.381 0.756757 0.20442 LARP4 - La-related protein 4 - Homo sapiens (Human) - LARP4 gene RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). Taurus_UMD|evm.model.AC_000162.1.245 Q71RC2 LARP4_HUMAN 87.319 0.99359 0.861878 LARP4 - La-related protein 4 - Homo sapiens (Human) - LARP4 gene RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). Taurus_UMD|evm.model.AC_000162.1.246 A6NE01 F186A_HUMAN 55.141 0.496515 1.03743 FAM186A - Protein FAM186A - Homo sapiens (Human) - FAM186A gene Taurus_UMD|evm.model.AC_000162.1.247 B0KYV5 LIMA1_PIG 85.220 0.985545 1.00661 LIMA1 - LIM domain and actin-binding protein 1 - Sus scrofa (Pig) - LIMA1 gene Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). Taurus_UMD|evm.model.AC_000162.1.248 Q8N5B7 CERS5_HUMAN 90.306 0.863135 1.15561 CERS5 - Ceramide synthase 5 - Homo sapiens (Human) - CERS5 gene Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor (PubMed:16951403, PubMed:18541923, PubMed:22144673, PubMed:22661289, PubMed:23530041, PubMed:26887952, PubMed:29632068, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). Taurus_UMD|evm.model.AC_000162.1.249 Q1RMH3 COX14_BOVIN 100.000 0.54902 1.78947 COX14 - Cytochrome c oxidase assembly protein COX14 - Bos taurus (Bovine) - COX14 gene Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1. Taurus_UMD|evm.model.AC_000162.1.250 Q5EA88 GPDA_BOVIN 100.000 0.763158 1.30659 GPD1 - Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic - Bos taurus (Bovine) - GPD1 gene Has glycerol-3-phosphate dehydrogenase activity. Taurus_UMD|evm.model.AC_000162.1.252 Q96GM5 SMRD1_HUMAN 99.612 0.996124 1.00194 SMARCD1 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 - Homo sapiens (Human) - SMARCD1 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342). Taurus_UMD|evm.model.AC_000162.1.253 P78348 ASIC1_HUMAN 79.767 0.891071 1.06061 ASIC1 - Acid-sensing ion channel 1 - Homo sapiens (Human) - ASIC1 gene Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. Taurus_UMD|evm.model.AC_000162.1.254 P78348 ASIC1_HUMAN 99.462 0.872642 0.401515 ASIC1 - Acid-sensing ion channel 1 - Homo sapiens (Human) - ASIC1 gene Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. Taurus_UMD|evm.model.AC_000162.1.255 Q9H0H5 RGAP1_HUMAN 95.253 0.99684 1.00158 RACGAP1 - Rac GTPase-activating protein 1 - Homo sapiens (Human) - RACGAP1 gene Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. Taurus_UMD|evm.model.AC_000162.1.256 Q9WTY0 AQP6_RAT 80.364 0.971631 1.02174 Aqp6 - Aquaporin-6 - Rattus norvegicus (Rat) - Aqp6 gene Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism. Taurus_UMD|evm.model.AC_000162.1.257 Q866S3 AQP5_SHEEP 96.981 0.676923 1.4717 AQP5 - Aquaporin-5 - Ovis aries (Sheep) - AQP5 gene Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity). Taurus_UMD|evm.model.AC_000162.1.258 P79099 AQP2_BOVIN 100.000 0.992647 1.00369 AQP2 - Aquaporin-2 - Bos taurus (Bovine) - AQP2 gene Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Taurus_UMD|evm.model.AC_000162.1.259 Q1LZ71 LFG2_BOVIN 100.000 0.993691 1.00316 FAIM2 - Protein lifeguard 2 - Bos taurus (Bovine) - FAIM2 gene Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development (By similarity). Taurus_UMD|evm.model.AC_000162.1.260 Q29S19 BN3D2_BOVIN 98.734 0.0512821 5.2089 BCDIN3D - RNA 5'-monophosphate methyltransferase - Bos taurus (Bovine) - BCDIN3D gene O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145. Taurus_UMD|evm.model.AC_000162.1.261 Q0V882 BI1_BOVIN 100.000 0.991561 1.00424 TMBIM6 - Bax inhibitor 1 - Bos taurus (Bovine) - TMBIM6 gene Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation. Taurus_UMD|evm.model.AC_000162.1.262 Q8IVF7 FMNL3_HUMAN 97.041 0.985409 1 FMNL3 - Formin-like protein 3 - Homo sapiens (Human) - FMNL3 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement. Taurus_UMD|evm.model.AC_000162.1.263 Q6NWY9 PR40B_HUMAN 89.707 0.97411 1.06429 PRPF40B - Pre-mRNA-processing factor 40 homolog B - Homo sapiens (Human) - PRPF40B gene May be involved in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000162.1.264 Q8IYM0 F186B_HUMAN 68.147 0.932079 1.07167 FAM186B - Protein FAM186B - Homo sapiens (Human) - FAM186B gene protein-containing complex Taurus_UMD|evm.model.AC_000162.1.265 Q96EZ8 MCRS1_HUMAN 99.351 0.99568 1.00216 MCRS1 - Microspherule protein 1 - Homo sapiens (Human) - MCRS1 gene Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602). Taurus_UMD|evm.model.AC_000162.1.266 Q9ULD8 KCNH3_HUMAN 94.373 0.99814 0.992613 KCNH3 - Potassium voltage-gated channel subfamily H member 3 - Homo sapiens (Human) - KCNH3 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly. Taurus_UMD|evm.model.AC_000162.1.267 Q86XZ4 SPAS2_HUMAN 88.278 0.996344 1.00367 SPATS2 - Spermatogenesis-associated serine-rich protein 2 - Homo sapiens (Human) - SPATS2 gene cytoplasm, cytosol, RNA binding Taurus_UMD|evm.model.AC_000162.1.268 Q17QW0 DJC22_BOVIN 100.000 0.994253 1.00288 DNAJC22 - DnaJ homolog subfamily C member 22 - Bos taurus (Bovine) - DNAJC22 gene May function as a co-chaperone. Taurus_UMD|evm.model.AC_000162.1.269 Q4ZJM9 C1QL4_MOUSE 99.153 0.806897 0.609244 C1ql4 - Complement C1q-like protein 4 precursor - Mus musculus (Mouse) - C1ql4 gene May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. May inhibit adipocyte differentiation at an early stage of the process. Taurus_UMD|evm.model.AC_000162.1.270 Q12815 TROAP_HUMAN 67.866 0.995828 0.924165 TROAP - Tastin - Homo sapiens (Human) - TROAP gene Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Taurus_UMD|evm.model.AC_000162.1.271 P49247 RPIA_HUMAN 73.000 0.826087 0.369775 RPIA - Ribose-5-phosphate isomerase - Homo sapiens (Human) - RPIA gene cytosol, intracellular membrane-bounded organelle, identical protein binding, ribose-5-phosphate isomerase activity, D-ribose metabolic process, pentose-phosphate shunt, pentose-phosphate shunt, non-oxidative branch Taurus_UMD|evm.model.AC_000162.1.272 A6QQJ3 PERI_BOVIN 99.787 0.995736 1 PRPH - Peripherin - Bos taurus (Bovine) - PRPH gene Class-III neuronal intermediate filament protein (By similarity). May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (By similarity). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (By similarity). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity). Taurus_UMD|evm.model.AC_000162.1.273 Q3ZCJ7 TBA1C_BOVIN 98.649 0.993266 0.66147 TUBA1C - Tubulin alpha-1C chain - Bos taurus (Bovine) - TUBA1C gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Taurus_UMD|evm.model.AC_000162.1.274 Q3ZCJ7 TBA1C_BOVIN 99.332 0.995556 1.00223 TUBA1C - Tubulin alpha-1C chain - Bos taurus (Bovine) - TUBA1C gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Taurus_UMD|evm.model.AC_000162.1.275 Q3ZCJ7 TBA1C_BOVIN 100.000 0.995556 1.00223 TUBA1C - Tubulin alpha-1C chain - Bos taurus (Bovine) - TUBA1C gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Taurus_UMD|evm.model.AC_000162.1.276 P68370 TBA1A_RAT 100.000 0.995575 1.00222 Tuba1a - Tubulin alpha-1A chain - Rattus norvegicus (Rat) - Tuba1a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Taurus_UMD|evm.model.AC_000162.1.277 P21741 MK_HUMAN 57.025 0.983333 0.839161 MDK - Midkine precursor - Homo sapiens (Human) - MDK gene Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:18469519, PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:24458438, PubMed:15466886, PubMed:12084985, PubMed:10772929). Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups (PubMed:12084985, PubMed:10212223). Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:10683378, PubMed:24458438, PubMed:22323540, PubMed:12084985, PubMed:15466886, PubMed:10772929). Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378, PubMed:24458438). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively (PubMed:10683378). Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (PubMed:22323540). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (By similarity). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (By similarity). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (By similarity). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival (PubMed:10212223). Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion (PubMed:12084985, PubMed:1768439). Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (PubMed:12084985). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (By similarity). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886, PubMed:1768439). Binds LRP1; promotes neuronal survival (PubMed:10772929). Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (PubMed:12122009). Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (PubMed:18469519). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (By similarity). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (By similarity). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity). Taurus_UMD|evm.model.AC_000162.1.278 Q6P9V9 TBA1B_RAT 100.000 0.995575 1.00222 Tuba1b - Tubulin alpha-1B chain - Rattus norvegicus (Rat) - Tuba1b gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Taurus_UMD|evm.model.AC_000162.1.279 Q6UX01 LMBRL_HUMAN 95.297 0.853357 1.15746 LMBR1L - Protein LMBR1L - Homo sapiens (Human) - LMBR1L gene Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (PubMed:11287427, PubMed:12591932, PubMed:23964685). Taurus_UMD|evm.model.AC_000162.1.280 Q61488 DHH_MOUSE 98.228 0.992443 1.00253 Dhh - Desert hedgehog protein precursor - Mus musculus (Mouse) - Dhh gene Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development. Taurus_UMD|evm.model.AC_000162.1.281 Q8TAI7 REBL1_HUMAN 95.082 0.98913 1.00546 RHEBL1 - GTPase RhebL1 precursor - Homo sapiens (Human) - RHEBL1 gene Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2. Taurus_UMD|evm.model.AC_000162.1.282 Q6PDK2 KMT2D_MOUSE 89.338 0.28079 0.996779 Kmt2d - Histone-lysine N-methyltransferase 2D - Mus musculus (Mouse) - Kmt2d gene Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. Taurus_UMD|evm.model.AC_000162.1.283 P58108 AAKG1_BOVIN 100.000 0.993958 1.00303 PRKAG1 - 5'-AMP-activated protein kinase subunit gamma-1 - Bos taurus (Bovine) - PRKAG1 gene AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (By similarity). Taurus_UMD|evm.model.AC_000162.1.284 O94850 DEND_HUMAN 80.029 0.994092 0.95218 DDN - Dendrin - Homo sapiens (Human) - DDN gene Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity). Taurus_UMD|evm.model.AC_000162.1.285 P04628 WNT1_HUMAN 98.649 0.994609 1.0027 WNT1 - Proto-oncogene Wnt-1 precursor - Homo sapiens (Human) - WNT1 gene Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:26902720, PubMed:28528193, PubMed:23656646). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646). Taurus_UMD|evm.model.AC_000162.1.286 O00744 WN10B_HUMAN 94.565 0.758264 1.24422 WNT10B - Protein Wnt-10b precursor - Homo sapiens (Human) - WNT10B gene Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin. Taurus_UMD|evm.model.AC_000162.1.287 P61207 ARF3_TAKRU 100.000 0.976923 0.718232 arf3 - ADP-ribosylation factor 3 - Takifugu rubripes (Japanese pufferfish) - arf3 gene GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Taurus_UMD|evm.model.AC_000162.1.288 Q2YDL5 FKB11_BOVIN 99.015 0.990148 1 FKBP11 - Peptidyl-prolyl cis-trans isomerase FKBP11 precursor - Bos taurus (Bovine) - FKBP11 gene PPIases accelerate the folding of proteins during protein synthesis. Taurus_UMD|evm.model.AC_000162.1.289 Q2TA16 DRC2_BOVIN 100.000 0.995992 1.00201 CCDC65 - Dynein regulatory complex subunit 2 - Bos taurus (Bovine) - CCDC65 gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Taurus_UMD|evm.model.AC_000162.1.290 Q2HJ68 RND1_BOVIN 100.000 0.991416 1.00431 RND1 - Rho-related GTP-binding protein Rho6 precursor - Bos taurus (Bovine) - RND1 gene Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (By similarity). Taurus_UMD|evm.model.AC_000162.1.291 Q9BUQ8 DDX23_HUMAN 99.390 0.997564 1.00122 DDX23 - Probable ATP-dependent RNA helicase DDX23 - Homo sapiens (Human) - DDX23 gene Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Taurus_UMD|evm.model.AC_000162.1.292 Q9MZL3 CACB3_BOVIN 100.000 0.995876 1.00207 CACNB3 - Voltage-dependent L-type calcium channel subunit beta-3 - Bos taurus (Bovine) - CACNB3 gene Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:10684870). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (PubMed:10684870). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Taurus_UMD|evm.model.AC_000162.1.293 O43306 ADCY6_HUMAN 95.462 0.998286 0.999144 ADCY6 - Adenylate cyclase type 6 - Homo sapiens (Human) - ADCY6 gene Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity). Taurus_UMD|evm.model.AC_000162.1.294 A0A1B0GTD5 TEX49_HUMAN 57.252 0.978022 0.694656 TEX49 - Testis-expressed protein 49 - Homo sapiens (Human) - TEX49 gene Taurus_UMD|evm.model.AC_000162.1.295 Q6T8E9 CCNT1_BOVIN 100.000 0.997253 1.00138 CCNT1 - Cyclin-T1 - Bos taurus (Bovine) - CCNT1 gene Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Taurus_UMD|evm.model.AC_000162.1.296 Q8BQR4 KANL2_MOUSE 98.190 0.86811 1.04527 Kansl2 - KAT8 regulatory NSL complex subunit 2 - Mus musculus (Mouse) - Kansl2 gene As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. Taurus_UMD|evm.model.AC_000162.1.297 P49282 NRAM2_MOUSE 57.059 0.548387 0.382042 Slc11a2 - Natural resistance-associated macrophage protein 2 - Mus musculus (Mouse) - Slc11a2 gene May serve to import iron into the mitochondria (By similarity). Important in metal transport, in particular iron. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. Taurus_UMD|evm.model.AC_000162.1.298 P00711 LALBA_BOVIN 100.000 0.986014 1.00704 LALBA - Alpha-lactalbumin precursor - Bos taurus (Bovine) - LALBA gene Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. Taurus_UMD|evm.model.AC_000162.1.299 Q8NGY5 OR6N1_HUMAN 49.495 0.796748 0.394231 OR6N1 - Olfactory receptor 6N1 - Homo sapiens (Human) - OR6N1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.300 Q8NGY5 OR6N1_HUMAN 49.462 0.686567 0.429487 OR6N1 - Olfactory receptor 6N1 - Homo sapiens (Human) - OR6N1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.301 Q96KK4 O10C1_HUMAN 42.202 0.923077 0.375 OR10C1 - Olfactory receptor 10C1 - Homo sapiens (Human) - OR10C1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.303 Q8NH09 OR8S1_HUMAN 47.393 0.993464 0.426184 OR8S1 - Olfactory receptor 8S1 - Homo sapiens (Human) - OR8S1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.305 Q3SZX7 CL054_BOVIN 100.000 0.984 1.00806 Uncharacterized protein C12orf54 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.306 Q96N77 ZN641_HUMAN 95.519 0.995294 0.97032 ZNF641 - Zinc finger protein 641 - Homo sapiens (Human) - ZNF641 gene Transcriptional activator. Activates transcriptional activities of SRE and AP-1. Taurus_UMD|evm.model.AC_000162.1.307 Q5RKG3 H1FNT_RAT 61.538 0.514286 0.586124 H1-7 - Testis-specific H1 histone - Rattus norvegicus (Rat) - H1-7 gene Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. Taurus_UMD|evm.model.AC_000162.1.308 Q5RKG3 H1FNT_RAT 61.538 0.514286 0.586124 H1-7 - Testis-specific H1 histone - Rattus norvegicus (Rat) - H1-7 gene Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. Taurus_UMD|evm.model.AC_000162.1.309 Q58DS6 JMJD6_BOVIN 82.609 0.822464 0.684864 JMJD6 - Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 - Bos taurus (Bovine) - JMJD6 gene Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation. Demethylates other arginine methylated-proteins such as ESR1. Has no histone lysine demethylase activity (By similarity). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (By similarity). Taurus_UMD|evm.model.AC_000162.1.310 Q92889 XPF_HUMAN 62.312 0.989744 0.212882 ERCC4 - DNA repair endonuclease XPF - Homo sapiens (Human) - ERCC4 gene Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. Taurus_UMD|evm.model.AC_000162.1.311 Q0VC19 CC184_BOVIN 100.000 0.989796 1.00513 CCDC184 - Coiled-coil domain-containing protein 184 - Bos taurus (Bovine) - CCDC184 gene cytoplasm Taurus_UMD|evm.model.AC_000162.1.312 Q08E43 ASB8_BOVIN 100.000 0.99308 1.00347 ASB8 - Ankyrin repeat and SOCS box protein 8 - Bos taurus (Bovine) - ASB8 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000162.1.313 Q0IIG5 PFKAM_BOVIN 100.000 0.997436 1.00128 PFKM - ATP-dependent 6-phosphofructokinase, muscle type - Bos taurus (Bovine) - PFKM gene Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Taurus_UMD|evm.model.AC_000162.1.314 Q5RBB1 SENP1_PONAB 89.457 0.862637 1.12868 SENP1 - Sentrin-specific protease 1 - Pongo abelii (Sumatran orangutan) - SENP1 gene Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Deconjugates SUMO2 from MTA1 (By similarity). Deconjugates SUMO1 from METTL3. Desumoylates CCAR2 which decreases its interaction with SIRT1. Deconjugates SUMO1 from GPS2. Taurus_UMD|evm.model.AC_000162.1.315 P02459 CO2A1_BOVIN 98.790 0.998639 0.988568 COL2A1 - Collagen alpha-1(II) chain precursor - Bos taurus (Bovine) - COL2A1 gene Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Taurus_UMD|evm.model.AC_000162.1.316 Q3T144 T106C_BOVIN 100.000 0.992 1.00402 TMEM106C - Transmembrane protein 106C - Bos taurus (Bovine) - TMEM106C gene Taurus_UMD|evm.model.AC_000162.1.317 A4FUH0 RL22L_BOVIN 90.164 0.982759 0.95082 RPL22L1 - 60S ribosomal protein L22-like 1 - Bos taurus (Bovine) - RPL22L1 gene RNA binding, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000162.1.318 Q28037 VDR_BOVIN 99.765 0.995305 1 VDR - Vitamin D3 receptor - Bos taurus (Bovine) - VDR gene Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). Taurus_UMD|evm.model.AC_000162.1.319 Q8WUI4 HDAC7_HUMAN 92.332 0.95846 1.03676 HDAC7 - Histone deacetylase 7 - Homo sapiens (Human) - HDAC7 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Taurus_UMD|evm.model.AC_000162.1.320 Q6P1K1 HRG1_HUMAN 95.890 0.986395 1.00685 SLC48A1 - Heme transporter HRG1 - Homo sapiens (Human) - SLC48A1 gene Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. Taurus_UMD|evm.model.AC_000162.1.321 O95398 RPGF3_HUMAN 92.573 0.997849 1.00758 RAPGEF3 - Rap guanine nucleotide exchange factor 3 - Homo sapiens (Human) - RAPGEF3 gene Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. Taurus_UMD|evm.model.AC_000162.1.322 A6QLQ8 ENDOU_BOVIN 100.000 0.995169 1.00242 ENDOU - Poly(U)-specific endoribonuclease precursor - Bos taurus (Bovine) - ENDOU gene Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini. Taurus_UMD|evm.model.AC_000162.1.323 Q9H6T3 RPAP3_HUMAN 87.988 0.996997 1.0015 RPAP3 - RNA polymerase II-associated protein 3 - Homo sapiens (Human) - RPAP3 gene Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Taurus_UMD|evm.model.AC_000162.1.324 Q9NX36 DJC28_HUMAN 74.157 0.991701 0.621134 DNAJC28 - DnaJ homolog subfamily C member 28 - Homo sapiens (Human) - DNAJC28 gene May have a role in protein folding or as a chaperone. Taurus_UMD|evm.model.AC_000162.1.325 P61928 RL37_RAT 82.955 0.887755 1.01031 Rpl37 - 60S ribosomal protein L37 - Rattus norvegicus (Rat) - Rpl37 gene Binds to the 23S rRNA. Taurus_UMD|evm.model.AC_000162.1.326 A6QL70 PED1B_BOVIN 100.000 0.901587 0.720824 PCED1B - PC-esterase domain-containing protein 1B - Bos taurus (Bovine) - PCED1B gene Taurus_UMD|evm.model.AC_000162.1.327 Q86SJ2 AMGO2_HUMAN 90.805 0.996169 1 AMIGO2 - Amphoterin-induced protein 2 precursor - Homo sapiens (Human) - AMIGO2 gene Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas. Taurus_UMD|evm.model.AC_000162.1.328 Q5RE87 S38A4_PONAB 93.967 0.99635 1.00183 SLC38A4 - Sodium-coupled neutral amino acid transporter 4 - Pongo abelii (Sumatran orangutan) - SLC38A4 gene Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by Ser, Gly, Cys, Asn, Thr, Pro and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with highest transport activity between pH 7.5 and 8.5 (By similarity). Taurus_UMD|evm.model.AC_000162.1.329 Q2VIR3 IF2GL_HUMAN 76.768 0.844828 0.245763 EIF2S3B - Eukaryotic translation initiation factor 2 subunit 3B - Homo sapiens (Human) - EIF2S3B gene As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). Taurus_UMD|evm.model.AC_000162.1.330 A2VE31 S38A2_BOVIN 100.000 0.765152 1.30435 SLC38A2 - Sodium-coupled neutral amino acid transporter 2 - Bos taurus (Bovine) - SLC38A2 gene Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta (By similarity). Taurus_UMD|evm.model.AC_000162.1.331 Q9H2H9 S38A1_HUMAN 86.858 0.995604 0.934292 SLC38A1 - Sodium-coupled neutral amino acid transporter 1 - Homo sapiens (Human) - SLC38A1 gene Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA. Taurus_UMD|evm.model.AC_000162.1.333 Q99590 SCAFB_HUMAN 79.850 0.997937 0.993848 SCAF11 - Protein SCAF11 - Homo sapiens (Human) - SCAF11 gene Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. Taurus_UMD|evm.model.AC_000162.1.334 Q68CP9 ARID2_HUMAN 93.464 0.998891 0.982561 ARID2 - AT-rich interactive domain-containing protein 2 - Homo sapiens (Human) - ARID2 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. Taurus_UMD|evm.model.AC_000162.1.336 Q17QR5 DBX2_BOVIN 90.294 0.993528 0.908824 DBX2 - Homeobox protein DBX2 - Bos taurus (Bovine) - DBX2 gene regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000162.1.337 A6QR11 NELL2_BOVIN 100.000 0.997552 1.00123 NELL2 - Protein kinase C-binding protein NELL2 precursor - Bos taurus (Bovine) - NELL2 gene cytoplasm, heparin binding, protein kinase C binding Taurus_UMD|evm.model.AC_000162.1.338 Q9H0C3 TM117_HUMAN 97.276 0.996117 1.00195 TMEM117 - Transmembrane protein 117 - Homo sapiens (Human) - TMEM117 gene Involved in endoplasmic reticulum (ER) stress-induced cell death pathway. Taurus_UMD|evm.model.AC_000162.1.339 Q56JV6 TWF1_BOVIN 100.000 0.906494 1.1 TWF1 - Twinfilin-1 - Bos taurus (Bovine) - TWF1 gene Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). Taurus_UMD|evm.model.AC_000162.1.340 Q1RMT8 IRAK4_BOVIN 100.000 0.995671 1.00217 IRAK4 - Interleukin-1 receptor-associated kinase 4 - Bos taurus (Bovine) - IRAK4 gene Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections (By similarity). Taurus_UMD|evm.model.AC_000162.1.341 Q9H0K6 PUS7L_HUMAN 83.024 0.969529 1.02996 PUS7L - Pseudouridylate synthase 7 homolog-like protein - Homo sapiens (Human) - PUS7L gene Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Taurus_UMD|evm.model.AC_000162.1.342 P59511 ATS20_MOUSE 79.670 0.933902 0.49213 Adamts20 - A disintegrin and metalloproteinase with thrombospondin motifs 20 precursor - Mus musculus (Mouse) - Adamts20 gene May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain. Taurus_UMD|evm.model.AC_000162.1.343 Q96EY1 DNJA3_HUMAN 92.758 0.932292 0.8 DNAJA3 - DnaJ homolog subfamily A member 3, mitochondrial precursor - Homo sapiens (Human) - DNAJA3 gene Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. Taurus_UMD|evm.model.AC_000162.1.345 Q56NI9 ESCO2_HUMAN 88.148 0.942857 0.232945 ESCO2 - N-acetyltransferase ESCO2 - Homo sapiens (Human) - ESCO2 gene Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). Taurus_UMD|evm.model.AC_000162.1.346 Q32L59 TMC5B_BOVIN 100.000 0.0968468 1.26496 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Taurus_UMD|evm.model.AC_000162.1.347 O15145 ARPC3_HUMAN 59.633 0.974026 0.432584 ARPC3 - Actin-related protein 2/3 complex subunit 3 - Homo sapiens (Human) - ARPC3 gene Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Taurus_UMD|evm.model.AC_000162.1.348 Q96MT3 PRIC1_HUMAN 91.837 0.920598 1.04573 PRICKLE1 - Prickle-like protein 1 precursor - Homo sapiens (Human) - PRICKLE1 gene Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. Taurus_UMD|evm.model.AC_000162.1.349 Q8NEY8 PPHLN_HUMAN 90.852 0.816062 0.842795 PPHLN1 - Periphilin-1 - Homo sapiens (Human) - PPHLN1 gene Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). Taurus_UMD|evm.model.AC_000162.1.350 Q56JZ7 ZCRB1_BOVIN 100.000 0.990826 1.00461 ZCRB1 - Zinc finger CCHC-type and RNA-binding motif-containing protein 1 - Bos taurus (Bovine) - ZCRB1 gene U12-type spliceosomal complex, mRNA splicing, via spliceosome Taurus_UMD|evm.model.AC_000162.1.351 Q8IY57 YAF2_HUMAN 96.479 0.42378 1.82222 YAF2 - YY1-associated factor 2 - Homo sapiens (Human) - YAF2 gene Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. Taurus_UMD|evm.model.AC_000162.1.352 Q4G148 GXLT1_HUMAN 91.818 0.995465 1.00227 GXYLT1 - Glucoside xylosyltransferase 1 - Homo sapiens (Human) - GXYLT1 gene Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose. Taurus_UMD|evm.model.AC_000162.1.353 Q96I25 SPF45_HUMAN 70.968 0.910891 0.25187 RBM17 - Splicing factor 45 - Homo sapiens (Human) - RBM17 gene Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. Taurus_UMD|evm.model.AC_000162.1.354 Q6ZMN7 PZRN4_HUMAN 91.536 0.968085 0.635135 PDZRN4 - PDZ domain-containing RING finger protein 4 - Homo sapiens (Human) - PDZRN4 gene Taurus_UMD|evm.model.AC_000162.1.355 Q6ZMN7 PZRN4_HUMAN 95.041 0.810811 0.142857 PDZRN4 - PDZ domain-containing RING finger protein 4 - Homo sapiens (Human) - PDZRN4 gene Taurus_UMD|evm.model.AC_000162.1.358 P12960 CNTN1_MOUSE 92.505 0.583622 0.85 Cntn1 - Contactin-1 precursor - Mus musculus (Mouse) - Cntn1 gene Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. Taurus_UMD|evm.model.AC_000162.1.359 P98091 MUCS_BOVIN 98.964 0.534819 0.637655 Submaxillary mucin-like protein - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.362 Q7Z5P9 MUC19_HUMAN 81.717 0.932535 0.109614 MUC19 - Mucin-19 precursor - Homo sapiens (Human) - MUC19 gene May function in ocular mucus homeostasis. Taurus_UMD|evm.model.AC_000162.1.363 P09651 ROA1_HUMAN 97.333 0.986755 0.405914 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Homo sapiens (Human) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). Taurus_UMD|evm.model.AC_000162.1.364 Q5S007 LRRK2_HUMAN 90.783 0.999209 1.0004 LRRK2 - Leucine-rich repeat serine/threonine-protein kinase 2 - Homo sapiens (Human) - LRRK2 gene Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, autophagy, and vesicle trafficking (PubMed:20949042, PubMed:22012985, PubMed:26824392, PubMed:29125462, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:30635421, PubMed:21850687, PubMed:23395371, PubMed:17114044, PubMed:24687852, PubMed:26014385, PubMed:25201882). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421, PubMed:23395371). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Independent of its kinase activity, inhibits the proteosomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:29125462, PubMed:28720718, PubMed:29212815). Taurus_UMD|evm.model.AC_000162.1.366 Q86WS4 CL040_HUMAN 58.710 0.856918 0.97546 C12orf40 - Uncharacterized protein C12orf40 - Homo sapiens (Human) - C12orf40 gene Taurus_UMD|evm.model.AC_000162.1.367 Q9UBJ2 ABCD2_HUMAN 94.340 0.997305 1.0027 ABCD2 - ATP-binding cassette sub-family D member 2 - Homo sapiens (Human) - ABCD2 gene Probable transporter. Taurus_UMD|evm.model.AC_000162.1.368 P19483 ATPA_BOVIN 84.545 0.981982 0.200723 ATP5F1A - ATP synthase subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - ATP5F1A gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity). Taurus_UMD|evm.model.AC_000162.1.369 P80021 ATPA_PIG 71.053 0.989474 0.34358 ATP5F1A - ATP synthase subunit alpha, mitochondrial precursor - Sus scrofa (Pig) - ATP5F1A gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity). Taurus_UMD|evm.model.AC_000162.1.370 Q7Z4S6 KI21A_HUMAN 94.507 0.998797 0.992832 KIF21A - Kinesin-like protein KIF21A - Homo sapiens (Human) - KIF21A gene Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity. Taurus_UMD|evm.model.AC_000162.1.371 Q28554 G3P_SHEEP 89.024 0.975904 0.257764 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Ovis aries (Sheep) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Taurus_UMD|evm.model.AC_000162.1.372 P10096 G3P_BOVIN 92.632 0.984375 0.576577 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Bos taurus (Bovine) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Taurus_UMD|evm.model.AC_000162.1.373 Q10126 YSM6_CAEEL 28.302 0.898089 0.562724 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000162.1.374 Q86YQ8 CPNE8_HUMAN 83.511 0.971831 0.881206 CPNE8 - Copine-8 - Homo sapiens (Human) - CPNE8 gene Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Taurus_UMD|evm.model.AC_000162.1.375 Q15256 PTPRR_HUMAN 93.151 0.996951 0.998478 PTPRR - Receptor-type tyrosine-protein phosphatase R precursor - Homo sapiens (Human) - PTPRR gene Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity). Taurus_UMD|evm.model.AC_000162.1.376 P23467 PTPRB_HUMAN 87.350 0.902351 1.10766 PTPRB - Receptor-type tyrosine-protein phosphatase beta precursor - Homo sapiens (Human) - PTPRB gene Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity). Taurus_UMD|evm.model.AC_000162.1.377 Q86W47 KCMB4_HUMAN 99.048 0.990521 1.00476 KCNMB4 - Calcium-activated potassium channel subunit beta-4 - Homo sapiens (Human) - KCNMB4 gene Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations. Taurus_UMD|evm.model.AC_000162.1.378 Q9NZN8 CNOT2_HUMAN 100.000 0.996303 1.00185 CNOT2 - CCR4-NOT transcription complex subunit 2 - Homo sapiens (Human) - CNOT2 gene Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. Taurus_UMD|evm.model.AC_000162.1.379 Q5RAZ9 RL36_PONAB 68.421 0.663462 0.990476 RPL36 - 60S ribosomal protein L36 - Pongo abelii (Sumatran orangutan) - RPL36 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000162.1.380 F1N4M2 MRFL_BOVIN 94.560 0.940782 0.998884 MYRFL - Myelin regulatory factor-like protein - Bos taurus (Bovine) - MYRFL gene endoplasmic reticulum membrane, nucleus, DNA-binding transcription factor activity, sequence-specific DNA binding, positive regulation of transcription, DNA-templated, protein autoprocessing Taurus_UMD|evm.model.AC_000162.1.381 Q96QF0 RAB3I_HUMAN 96.304 0.995662 0.968487 RAB3IP - Rab-3A-interacting protein - Homo sapiens (Human) - RAB3IP gene Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Taurus_UMD|evm.model.AC_000162.1.382 Q8N1M1 BEST3_HUMAN 79.756 0.776442 1.24551 BEST3 - Bestrophin-3 - Homo sapiens (Human) - BEST3 gene Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Taurus_UMD|evm.model.AC_000162.1.383 Q24K06 LRC10_BOVIN 100.000 0.992832 1.0036 LRRC10 - Leucine-rich repeat-containing protein 10 - Bos taurus (Bovine) - LRRC10 gene May play important roles in cardiac development and/or cardiac function. Taurus_UMD|evm.model.AC_000162.1.384 Q3ZBH0 TCPB_BOVIN 100.000 0.996269 1.00187 CCT2 - T-complex protein 1 subunit beta - Bos taurus (Bovine) - CCT2 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Taurus_UMD|evm.model.AC_000162.1.385 Q8WU20 FRS2_HUMAN 98.228 0.996071 1.00197 FRS2 - Fibroblast growth factor receptor substrate 2 - Homo sapiens (Human) - FRS2 gene Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. Taurus_UMD|evm.model.AC_000162.1.386 Q9CR11 YETS4_MOUSE 99.559 0.991228 1.00441 Yeats4 - YEATS domain-containing protein 4 - Mus musculus (Mouse) - Yeats4 gene Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (By similarity). Also able to recognize and bind crotonylated histone H3 (By similarity). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (By similarity). Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (By similarity). H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (PubMed:29900004). Taurus_UMD|evm.model.AC_000162.1.387 Q6B411 LYSM_BOVIN 100.000 0.986577 1.00676 Lysozyme C, milk isozyme precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.388 Q27996 LYSCT_BOVIN 93.197 0.874251 1.13605 Lysozyme C, tracheal isozyme precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.389 Q27996 LYSCT_BOVIN 97.959 0.874251 1.13605 Lysozyme C, tracheal isozyme precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.390 Q6B411 LYSM_BOVIN 84.615 0.716049 1.09459 Lysozyme C, milk isozyme precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.391 Q6B410 LYSI_BOVIN 96.324 0.457627 2.0068 Lysozyme C, intestinal isozyme precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.392 Q06283 LYSC2_BOVIN 100.000 0.986486 1.0068 LYZ2 - Lysozyme C-2 precursor - Bos taurus (Bovine) - LYZ2 gene Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Taurus_UMD|evm.model.AC_000162.1.393 Q06285 LYSC1_BOVIN 100.000 0.986486 1.0068 LYZ1 - Lysozyme C-1 precursor - Bos taurus (Bovine) - LYZ1 gene Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Taurus_UMD|evm.model.AC_000162.1.394 Q06284 LYSC3_BOVIN 100.000 0.986486 1.0068 LYZ3 - Lysozyme C-3 precursor - Bos taurus (Bovine) - LYZ3 gene Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Taurus_UMD|evm.model.AC_000162.1.395 P80189 LYSCN_BOVIN 100.000 0.986577 1.00676 LYS - Lysozyme C, non-stomach isozyme precursor - Bos taurus (Bovine) - LYS gene Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Taurus_UMD|evm.model.AC_000162.1.396 Q16630 CPSF6_HUMAN 93.548 0.99661 1.07078 CPSF6 - Cleavage and polyadenylation specificity factor subunit 6 - Homo sapiens (Human) - CPSF6 gene Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460). Taurus_UMD|evm.model.AC_000162.1.397 P60868 RS20_RAT 78.151 0.983193 1 Rps20 - 40S ribosomal protein S20 - Rattus norvegicus (Rat) - Rps20 gene cytosolic small ribosomal subunit, small ribosomal subunit, synapse, structural constituent of ribosome Taurus_UMD|evm.model.AC_000162.1.398 Q5RFD6 CBPM_PONAB 83.916 0.963883 1 CPM - Carboxypeptidase M precursor - Pongo abelii (Sumatran orangutan) - CPM gene Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins (By similarity). Taurus_UMD|evm.model.AC_000162.1.399 P56951 MDM2_HORSE 99.593 0.995935 1.00204 MDM2 - E3 ubiquitin-protein ligase Mdm2 - Equus caballus (Horse) - MDM2 gene E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells. Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (By similarity). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (By similarity). Taurus_UMD|evm.model.AC_000162.1.400 A4IFK2 S35E3_BOVIN 100.000 0.993631 1.00319 SLC35E3 - Solute carrier family 35 member E3 - Bos taurus (Bovine) - SLC35E3 gene Putative transporter. Taurus_UMD|evm.model.AC_000162.1.401 P57740 NU107_HUMAN 94.264 0.99676 1.00108 NUP107 - Nuclear pore complex protein Nup107 - Homo sapiens (Human) - NUP107 gene Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). Taurus_UMD|evm.model.AC_000162.1.402 Q5RDM6 RAP1B_PONAB 100.000 0.989189 1.00543 RAP1B - Ras-related protein Rap-1b precursor - Pongo abelii (Sumatran orangutan) - RAP1B gene GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity). Taurus_UMD|evm.model.AC_000162.1.403 Q5RC32 MDM1_PONAB 80.624 0.996705 0.838398 MDM1 - Nuclear protein MDM1 - Pongo abelii (Sumatran orangutan) - MDM1 gene Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules. Taurus_UMD|evm.model.AC_000162.1.404 Q8TC05 MDM1_HUMAN 78.333 0.880597 0.0938375 MDM1 - Nuclear protein MDM1 - Homo sapiens (Human) - MDM1 gene Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). Taurus_UMD|evm.model.AC_000162.1.405 Q9GZX6 IL22_HUMAN 69.274 0.931937 1.06704 IL22 - Interleukin-22 precursor - Homo sapiens (Human) - IL22 gene Cytokine that contributes to the inflammatory response in vivo. Taurus_UMD|evm.model.AC_000162.1.406 Q90YS3 RS2_ICTPU 84.783 0.669118 0.490975 rps2 - 40S ribosomal protein S2 - Ictalurus punctatus (Channel catfish) - rps2 gene Taurus_UMD|evm.model.AC_000162.1.407 Q9NPH9 IL26_HUMAN 80.220 0.732794 1.44444 IL26 - Interleukin-26 precursor - Homo sapiens (Human) - IL26 gene May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. Taurus_UMD|evm.model.AC_000162.1.408 P07353 IFNG_BOVIN 100.000 0.705556 1.08434 IFNG - Interferon gamma precursor - Bos taurus (Bovine) - IFNG gene Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity). Taurus_UMD|evm.model.AC_000162.1.409 Q92630 DYRK2_HUMAN 98.170 0.996667 0.998336 DYRK2 - Dual specificity tyrosine-phosphorylation-regulated kinase 2 - Homo sapiens (Human) - DYRK2 gene Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). Taurus_UMD|evm.model.AC_000162.1.411 Q86VP6 CAND1_HUMAN 100.000 0.998375 1.00081 CAND1 - Cullin-associated NEDD8-dissociated protein 1 - Homo sapiens (Human) - CAND1 gene Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. Taurus_UMD|evm.model.AC_000162.1.412 Q8CB14 LAS2_MOUSE 67.568 0.151261 0.452471 Las2 - Lung adenoma susceptibility protein 2 precursor - Mus musculus (Mouse) - Las2 gene Might play a role in cell proliferation. Taurus_UMD|evm.model.AC_000162.1.413 Q9Y3R0 GRIP1_HUMAN 94.013 0.994585 0.98227 GRIP1 - Glutamate receptor-interacting protein 1 - Homo sapiens (Human) - GRIP1 gene May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). Taurus_UMD|evm.model.AC_000162.1.414 Q8NG08 HELB_HUMAN 75.138 0.998145 0.99172 HELB - DNA helicase B - Homo sapiens (Human) - HELB gene 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613). Taurus_UMD|evm.model.AC_000162.1.415 Q9Y616 IRAK3_HUMAN 83.122 0.946644 0.974832 IRAK3 - Interleukin-1 receptor-associated kinase 3 - Homo sapiens (Human) - IRAK3 gene Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). Taurus_UMD|evm.model.AC_000162.1.416 Q9HC24 LFG4_HUMAN 85.714 0.991632 1.0042 TMBIM4 - Protein lifeguard 4 - Homo sapiens (Human) - TMBIM4 gene Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release. Taurus_UMD|evm.model.AC_000162.1.417 Q2TBR9 CL031_BOVIN 100.000 0.984375 1.00787 Uncharacterized protein C12orf31 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.419 Q8IXL7 MSRB3_HUMAN 91.824 0.987421 0.828125 MSRB3 - Methionine-R-sulfoxide reductase B3 precursor - Homo sapiens (Human) - MSRB3 gene Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing. Taurus_UMD|evm.model.AC_000162.1.421 Q9Y2U8 MAN1_HUMAN 83.260 0.99763 0.926454 LEMD3 - Inner nuclear membrane protein Man1 - Homo sapiens (Human) - LEMD3 gene Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. Taurus_UMD|evm.model.AC_000162.1.422 Q9Y5W5 WIF1_HUMAN 93.140 0.994737 1.00264 WIF1 - Wnt inhibitory factor 1 precursor - Homo sapiens (Human) - WIF1 gene Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. Taurus_UMD|evm.model.AC_000162.1.423 Q9Y2I9 TBC30_HUMAN 86.272 0.947503 0.845238 TBC1D30 - TBC1 domain family member 30 - Homo sapiens (Human) - TBC1D30 gene GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro. Taurus_UMD|evm.model.AC_000162.1.424 Q8IUQ4 SIAH1_HUMAN 85.106 0.728495 1.31915 SIAH1 - E3 ubiquitin-protein ligase SIAH1 - Homo sapiens (Human) - SIAH1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP (PubMed:10747903, PubMed:11146551, PubMed:11389839, PubMed:11389840, PubMed:11483517, PubMed:11483518, PubMed:11752454, PubMed:12072443). Confers constitutive instability to HIPK2 through proteasomal degradation (PubMed:18536714). It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Has some overlapping function with SIAH2 (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Induces apoptosis in cooperation with PEG3 (By similarity). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus (By similarity). GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Taurus_UMD|evm.model.AC_000162.1.425 Q9Y2I9 TBC30_HUMAN 72.430 0.913876 0.22619 TBC1D30 - TBC1 domain family member 30 - Homo sapiens (Human) - TBC1D30 gene GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro. Taurus_UMD|evm.model.AC_000162.1.426 Q1LZH9 GNS_BOVIN 99.821 0.996435 1.00179 GNS - N-acetylglucosamine-6-sulfatase precursor - Bos taurus (Bovine) - GNS gene glycosaminoglycan binding, N-acetylglucosamine-6-sulfatase activity Taurus_UMD|evm.model.AC_000162.1.427 Q86WH2 RASF3_HUMAN 93.122 0.978836 0.794118 RASSF3 - Ras association domain-containing protein 3 - Homo sapiens (Human) - RASSF3 gene cytoplasm, cytosol, plasma membrane, identical protein binding, signal transduction Taurus_UMD|evm.model.AC_000162.1.428 Q9UHD2 TBK1_HUMAN 97.119 0.99726 1.00137 TBK1 - Serine/threonine-protein kinase TBK1 - Homo sapiens (Human) - TBK1 gene Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:10581243, PubMed:11839743, PubMed:15485837, PubMed:21138416, PubMed:25636800, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:26611359, PubMed:32404352). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates and activates AKT1 (PubMed:21464307). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Taurus_UMD|evm.model.AC_000162.1.429 O43592 XPOT_HUMAN 99.064 0.997923 1.00104 XPOT - Exportin-T - Homo sapiens (Human) - XPOT gene Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Taurus_UMD|evm.model.AC_000162.1.430 Q8IXR9 CL056_HUMAN 82.986 0.985692 1.01125 C12orf56 - Uncharacterized protein C12orf56 - Homo sapiens (Human) - C12orf56 gene Taurus_UMD|evm.model.AC_000162.1.431 Q96MD2 CL066_HUMAN 97.079 0.995516 1.00225 KICS2 - KICSTOR subunit 2 - Homo sapiens (Human) - KICS2 gene As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. Taurus_UMD|evm.model.AC_000162.1.432 Q7Z6B7 SRGP1_HUMAN 98.157 0.998158 1.00092 SRGAP1 - SLIT-ROBO Rho GTPase-activating protein 1 - Homo sapiens (Human) - SRGAP1 gene GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. Taurus_UMD|evm.model.AC_000162.1.433 Q9Y2B1 RXLT1_HUMAN 85.779 0.995495 1.00226 RXYLT1 - Ribitol-5-phosphate xylosyltransferase 1 - Homo sapiens (Human) - RXYLT1 gene UDP-xylosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:27601598, PubMed:27733679) (Probable). Acts as a UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase, which catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O-mannosyl glycan (PubMed:27733679, PubMed:29477842) (Probable). Taurus_UMD|evm.model.AC_000162.1.434 Q3ZBL4 LZTL1_BOVIN 100.000 0.965517 0.19398 LZTFL1 - Leucine zipper transcription factor-like protein 1 - Bos taurus (Bovine) - LZTFL1 gene Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function (By similarity). Taurus_UMD|evm.model.AC_000162.1.437 P48043 V1AR_SHEEP 94.568 0.950588 1.01675 AVPR1A - Vasopressin V1a receptor - Ovis aries (Sheep) - AVPR1A gene Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000162.1.439 Q3UYC0 PPM1H_MOUSE 96.887 0.996117 1.0039 Ppm1h - Protein phosphatase 1H - Mus musculus (Mouse) - Ppm1h gene Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation. Taurus_UMD|evm.model.AC_000162.1.440 Q7Z3U7 MON2_HUMAN 97.849 0.998838 1.00233 MON2 - Protein MON2 homolog - Homo sapiens (Human) - MON2 gene Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. Taurus_UMD|evm.model.AC_000162.1.441 Q9Y4E8 UBP15_HUMAN 98.675 0.997963 1.00102 USP15 - Ubiquitin carboxyl-terminal hydrolase 15 - Homo sapiens (Human) - USP15 gene Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:21947082, PubMed:22344298, PubMed:24852371, PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:33093067). May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19826004, PubMed:19576224). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102). Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9 (PubMed:33093067). Taurus_UMD|evm.model.AC_000162.1.442 Q8N3H0 TAFA2_HUMAN 100.000 0.984848 1.00763 TAFA2 - Chemokine-like protein TAFA-2 precursor - Homo sapiens (Human) - TAFA2 gene Has a role as neurotrophic factor involved in neuronal survival and neurobiological functions. Taurus_UMD|evm.model.AC_000162.1.443 Q5RCP8 H2B2E_PONAB 87.611 0.973913 0.912698 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000162.1.447 O60669 MOT2_HUMAN 79.545 0.995859 1.01046 SLC16A7 - Monocarboxylate transporter 2 - Homo sapiens (Human) - SLC16A7 gene Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter. Taurus_UMD|evm.model.AC_000162.1.448 P19483 ATPA_BOVIN 87.703 0.996024 0.909584 ATP5F1A - ATP synthase subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - ATP5F1A gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity). Taurus_UMD|evm.model.AC_000162.1.450 Q6IV77 TAZ_MACMU 96.403 0.816568 0.645038 TAZ - Tafazzin - Macaca mulatta (Rhesus macaque) - TAZ gene Acyltransferase which is required to maintain the composition of the phospholipid cardiolipin, a key component of the mitochondrial inner membrane (By similarity). Required for the initiation of mitophagy (By similarity). Required to ensure progression of spermatocytes through meiosis (By similarity). Taurus_UMD|evm.model.AC_000162.1.451 Q6UXM1 LRIG3_HUMAN 89.008 0.998174 0.978552 LRIG3 - Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor - Homo sapiens (Human) - LRIG3 gene May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). Taurus_UMD|evm.model.AC_000162.1.452 Q9Y6H3 ATP23_HUMAN 90.244 0.991903 1.00407 ATP23 - Mitochondrial inner membrane protease ATP23 homolog - Homo sapiens (Human) - ATP23 gene cell junction, cytosol, DNA-dependent protein kinase-DNA ligase 4 complex, extrinsic component of mitochondrial inner membrane, intracellular membrane-bounded organelle, plasma membrane, DNA-dependent protein kinase activity, double-strand break repair via nonhomologous end joining, mitochondrial protein processing, mitochondrial proton-transporting ATP synthase complex assembly Taurus_UMD|evm.model.AC_000162.1.453 O14595 CTDS2_HUMAN 98.524 0.992647 1.00369 CTDSP2 - Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 - Homo sapiens (Human) - CTDSP2 gene Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. Taurus_UMD|evm.model.AC_000162.1.454 O75366 AVIL_HUMAN 90.232 0.997552 0.997558 AVIL - Advillin - Homo sapiens (Human) - AVIL gene Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling (PubMed:29058690). May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (PubMed:29058690). Taurus_UMD|evm.model.AC_000162.1.455 P43896 EFTS_BOVIN 100.000 0.9941 1.00296 TSFM - Elongation factor Ts, mitochondrial precursor - Bos taurus (Bovine) - TSFM gene Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Taurus_UMD|evm.model.AC_000162.1.456 A4FV98 EFMT3_BOVIN 100.000 0.991189 1.00442 EEF1AKMT3 - EEF1A lysine methyltransferase 3 - Bos taurus (Bovine) - EEF1AKMT3 gene Protein-lysine methyltransferase that selectively methylates EEF1A1 and EEF1A2 at 'Lys-165' in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation. Taurus_UMD|evm.model.AC_000162.1.457 Q2YDF1 TRMB_BOVIN 100.000 0.992806 1.00361 METTL1 - tRNA (guanine-N(7)-)-methyltransferase - Bos taurus (Bovine) - METTL1 gene Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs regulates translation. Also methylates a specific subset of miRNAs, such as let-7. N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA). Acts as a regulator of embryonic stem cell self-renewal and differentiation. Taurus_UMD|evm.model.AC_000162.1.458 O15528 CP27B_HUMAN 88.409 0.996071 1.00197 CYP27B1 - 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor - Homo sapiens (Human) - CYP27B1 gene A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1alpha-position to form the hormonally active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR) (PubMed:10518789, PubMed:9486994, PubMed:22862690, PubMed:10566658, PubMed:12050193). Has 1alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway (PubMed:10518789, PubMed:22862690). Converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR. Also active on 25-hydroxyvitamin D2 (PubMed:10518789). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:22862690). Taurus_UMD|evm.model.AC_000162.1.459 Q3TZ87 MARH9_MOUSE 96.839 0.994236 0.997126 Marchf9 - E3 ubiquitin-protein ligase MARCHF9 - Mus musculus (Mouse) - Marchf9 gene E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Taurus_UMD|evm.model.AC_000162.1.460 B2MVY4 CDK4_SHEEP 100.000 0.993421 1.0033 Cyclin-dependent kinase 4 - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000162.1.461 Q32KP1 TSN31_BOVIN 100.000 0.990521 1.00476 TSPAN31 - Tetraspanin-31 - Bos taurus (Bovine) - TSPAN31 gene integral component of plasma membrane Taurus_UMD|evm.model.AC_000162.1.462 Q99490 AGAP2_HUMAN 92.869 0.998289 0.980705 AGAP2 - Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 - Homo sapiens (Human) - AGAP2 gene GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. Taurus_UMD|evm.model.AC_000162.1.463 Q3MHX6 OS9_BOVIN 99.850 0.997006 1.0015 OS9 - Protein OS-9 precursor - Bos taurus (Bovine) - OS9 gene Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 (By similarity). Taurus_UMD|evm.model.AC_000162.1.464 Q00973 B4GN1_HUMAN 90.994 0.996255 1.00188 B4GALNT1 - Beta-1,4 N-acetylgalactosaminyltransferase 1 - Homo sapiens (Human) - B4GALNT1 gene Involved in the biosynthesis of gangliosides GM2, GD2, GT2 and GA2 from GM3, GD3, GT3 and GA3, respectively. Taurus_UMD|evm.model.AC_000162.1.465 Q80V91 DTX3_MOUSE 98.271 0.475928 2.0951 Dtx3 - Probable E3 ubiquitin-protein ligase DTX3 - Mus musculus (Mouse) - Dtx3 gene Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Taurus_UMD|evm.model.AC_000162.1.466 Q86VW2 ARHGP_HUMAN 95.255 0.882258 1.06897 ARHGEF25 - Rho guanine nucleotide exchange factor 25 - Homo sapiens (Human) - ARHGEF25 gene May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). Taurus_UMD|evm.model.AC_000162.1.467 Q5EBI0 S2610_MOUSE 84.244 0.995169 0.918639 Slc26a10 - Solute carrier family 26 member 10 - Mus musculus (Mouse) - Slc26a10 gene Chloride/bicarbonate exchanger. Taurus_UMD|evm.model.AC_000162.1.468 Q0P5F7 PI42C_BOVIN 98.305 0.816901 0.168646 PIP4K2C - Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma - Bos taurus (Bovine) - PIP4K2C gene Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3. Taurus_UMD|evm.model.AC_000162.1.469 Q12840 KIF5A_HUMAN 98.934 0.998064 1.00097 KIF5A - Kinesin heavy chain isoform 5A - Homo sapiens (Human) - KIF5A gene Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. Taurus_UMD|evm.model.AC_000162.1.470 Q3ZCF0 DCTN2_BOVIN 100.000 0.99505 1.00248 DCTN2 - Dynactin subunit 2 - Bos taurus (Bovine) - DCTN2 gene Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). Taurus_UMD|evm.model.AC_000162.1.471 Q96DN6 MBD6_HUMAN 94.836 0.998016 1.00499 MBD6 - Methyl-CpG-binding domain protein 6 - Homo sapiens (Human) - MBD6 gene Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro). Taurus_UMD|evm.model.AC_000162.1.472 Q0IIB6 DDIT3_BOVIN 100.000 0.988166 1.00595 DDIT3 - DNA damage-inducible transcript 3 protein - Bos taurus (Bovine) - DDIT3 gene Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response (By similarity). Taurus_UMD|evm.model.AC_000162.1.473 Q2T9L8 SYMC_BOVIN 99.889 0.997775 1.00111 MARS1 - Methionine--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - MARS1 gene Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus. Taurus_UMD|evm.model.AC_000162.1.474 Q9BRR9 RHG09_HUMAN 82.082 0.997301 0.988 ARHGAP9 - Rho GTPase-activating protein 9 - Homo sapiens (Human) - ARHGAP9 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. Taurus_UMD|evm.model.AC_000162.1.475 P08151 GLI1_HUMAN 89.964 0.998192 1 GLI1 - Zinc finger protein GLI1 - Homo sapiens (Human) - GLI1 gene Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). Taurus_UMD|evm.model.AC_000162.1.476 P58166 INHBE_HUMAN 82.051 0.994269 0.997143 INHBE - Inhibin beta E chain precursor - Homo sapiens (Human) - INHBE gene Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Taurus_UMD|evm.model.AC_000162.1.477 P55103 INHBC_HUMAN 79.167 0.949008 1.00284 INHBC - Inhibin beta C chain precursor - Homo sapiens (Human) - INHBC gene Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Taurus_UMD|evm.model.AC_000162.1.478 A0JNC2 R3HD2_BOVIN 97.679 0.513966 1.08595 R3HDM2 - R3H domain-containing protein 2 - Bos taurus (Bovine) - R3HDM2 gene Taurus_UMD|evm.model.AC_000162.1.479 Q96MF2 STAC3_HUMAN 96.429 0.99449 0.997253 STAC3 - SH3 and cysteine-rich domain-containing protein 3 - Homo sapiens (Human) - STAC3 gene Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels (PubMed:23736855, PubMed:29078335). Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (By similarity). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:29078335). Taurus_UMD|evm.model.AC_000162.1.480 Q3SZ44 NUA4L_BOVIN 100.000 0.977273 1.01149 NDUFA4L2 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 - Bos taurus (Bovine) - NDUFA4L2 gene mitochondrial respiratory chain complex IV Taurus_UMD|evm.model.AC_000162.1.481 Q3SZ20 GLYM_BOVIN 100.000 0.99604 1.00198 SHMT2 - Serine hydroxymethyltransferase, mitochondrial precursor - Bos taurus (Bovine) - SHMT2 gene Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs. Associates with mitochondrial DNA. In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex. Taurus_UMD|evm.model.AC_000162.1.482 O95158 NXPH4_HUMAN 86.495 0.993528 1.00325 NXPH4 - Neurexophilin-4 precursor - Homo sapiens (Human) - NXPH4 gene May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Taurus_UMD|evm.model.AC_000162.1.483 Q07954 LRP1_HUMAN 97.909 0.999559 0.997139 LRP1 - Prolow-density lipoprotein receptor-related protein 1 precursor - Homo sapiens (Human) - LRP1 gene Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:26142438, PubMed:1702392). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). Taurus_UMD|evm.model.AC_000162.1.484 Q4GWZ2 RSSA_PIG 90.000 0.980198 0.342373 RPSA - 40S ribosomal protein SA - Sus scrofa (Pig) - RPSA gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. Taurus_UMD|evm.model.AC_000162.1.485 P42226 STAT6_HUMAN 92.798 0.997642 1.00118 STAT6 - Signal transducer and activator of transcription 6 - Homo sapiens (Human) - STAT6 gene Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. Taurus_UMD|evm.model.AC_000162.1.486 Q15742 NAB2_HUMAN 98.286 0.996198 1.0019 NAB2 - NGFI-A-binding protein 2 - Homo sapiens (Human) - NAB2 gene Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). Taurus_UMD|evm.model.AC_000162.1.487 A7MBC7 NEMP1_BOVIN 93.018 0.993274 1.00225 NEMP1 - Nuclear envelope integral membrane protein 1 precursor - Bos taurus (Bovine) - NEMP1 gene nuclear envelope Taurus_UMD|evm.model.AC_000162.1.488 P10568 MYO1A_BOVIN 100.000 0.854321 1.16491 MYO1A - Unconventional myosin-Ia - Bos taurus (Bovine) - MYO1A gene Involved in directing the movement of organelles along actin filaments. Taurus_UMD|evm.model.AC_000162.1.489 O15060 ZBT39_HUMAN 92.697 0.997175 0.994382 ZBTB39 - Zinc finger and BTB domain-containing protein 39 - Homo sapiens (Human) - ZBTB39 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000162.1.490 O15218 GP182_HUMAN 79.016 0.977157 0.975248 GPR182 - G-protein coupled receptor 182 - Homo sapiens (Human) - GPR182 gene Orphan receptor. Taurus_UMD|evm.model.AC_000162.1.491 Q3T001 H17B6_BOVIN 76.744 0.545455 0.242902 HSD17B6 - 17-beta-hydroxysteroid dehydrogenase type 6 precursor - Bos taurus (Bovine) - HSD17B6 gene NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids (By similarity). Taurus_UMD|evm.model.AC_000162.1.492 O14756 H17B6_HUMAN 80.952 0.10199 1.26814 HSD17B6 - 17-beta-hydroxysteroid dehydrogenase type 6 precursor - Homo sapiens (Human) - HSD17B6 gene NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. Taurus_UMD|evm.model.AC_000162.1.493 O75452 RDH16_HUMAN 73.770 0.641138 1.44164 RDH16 - Retinol dehydrogenase 16 - Homo sapiens (Human) - RDH16 gene Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409). Has higher activity towards CRBP-bound retinol than with free retinol (PubMed:12534290). Oxidizes also 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (PubMed:10329026, PubMed:9677409, PubMed:29541409). Taurus_UMD|evm.model.AC_000162.1.494 O75452 RDH16_HUMAN 79.180 0.993711 1.00315 RDH16 - Retinol dehydrogenase 16 - Homo sapiens (Human) - RDH16 gene Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409). Has higher activity towards CRBP-bound retinol than with free retinol (PubMed:12534290). Oxidizes also 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (PubMed:10329026, PubMed:9677409, PubMed:29541409). Taurus_UMD|evm.model.AC_000162.1.495 Q3T001 H17B6_BOVIN 75.000 0.636364 0.312303 HSD17B6 - 17-beta-hydroxysteroid dehydrogenase type 6 precursor - Bos taurus (Bovine) - HSD17B6 gene NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids (By similarity). Taurus_UMD|evm.model.AC_000162.1.496 A4IFM3 DR9C7_BOVIN 100.000 0.993631 1.00319 SDR9C7 - Short-chain dehydrogenase/reductase family 9C member 7 - Bos taurus (Bovine) - SDR9C7 gene Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity (By similarity). Taurus_UMD|evm.model.AC_000162.1.497 O75452 RDH16_HUMAN 61.238 0.979933 0.943218 RDH16 - Retinol dehydrogenase 16 - Homo sapiens (Human) - RDH16 gene Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409). Has higher activity towards CRBP-bound retinol than with free retinol (PubMed:12534290). Oxidizes also 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (PubMed:10329026, PubMed:9677409, PubMed:29541409). Taurus_UMD|evm.model.AC_000162.1.498 Q3T001 H17B6_BOVIN 99.369 0.993711 1.00315 HSD17B6 - 17-beta-hydroxysteroid dehydrogenase type 6 precursor - Bos taurus (Bovine) - HSD17B6 gene NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids (By similarity). Taurus_UMD|evm.model.AC_000162.1.499 P49642 PRI1_HUMAN 86.136 0.995444 1.04524 PRIM1 - DNA primase small subunit - Homo sapiens (Human) - PRIM1 gene Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:9268648, PubMed:9705292, PubMed:17893144). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144). Can add both ribo- and deoxynucleotides during elongation of the primers (By similarity). Binds single stranded DNA (By similarity). Taurus_UMD|evm.model.AC_000162.1.500 Q5E9A1 NACA_BOVIN 100.000 0.550129 1.8093 NACA - Nascent polypeptide-associated complex subunit alpha - Bos taurus (Bovine) - NACA gene Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. Taurus_UMD|evm.model.AC_000162.1.501 P00829 ATPB_BOVIN 100.000 0.996219 1.00189 ATP5F1B - ATP synthase subunit beta, mitochondrial precursor - Bos taurus (Bovine) - ATP5F1B gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Taurus_UMD|evm.model.AC_000162.1.502 Q9UIF9 BAZ2A_HUMAN 90.976 0.998946 0.995801 BAZ2A - Bromodomain adjacent to zinc finger domain protein 2A - Homo sapiens (Human) - BAZ2A gene Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). Taurus_UMD|evm.model.AC_000162.1.503 Q3ZC34 RBMS2_BOVIN 100.000 0.995098 1.00246 RBMS2 - RNA-binding motif, single-stranded-interacting protein 2 - Bos taurus (Bovine) - RBMS2 gene cytosol, nucleus, ribonucleoprotein complex, mRNA 3'-UTR binding, poly(A) binding, poly(U) RNA binding, RNA binding Taurus_UMD|evm.model.AC_000162.1.504 Q9UI32 GLSL_HUMAN 94.850 0.996683 1.00166 GLS2 - Glutaminase liver isoform, mitochondrial precursor - Homo sapiens (Human) - GLS2 gene Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. Taurus_UMD|evm.model.AC_000162.1.505 Q8WW59 SPRY4_HUMAN 90.338 0.990385 1.00483 SPRYD4 - SPRY domain-containing protein 4 - Homo sapiens (Human) - SPRYD4 gene nucleus Taurus_UMD|evm.model.AC_000162.1.506 P06624 MIP_BOVIN 100.000 0.992424 1.0038 MIP - Lens fiber major intrinsic protein - Bos taurus (Bovine) - MIP gene Water channel (PubMed:23893133). Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling. Taurus_UMD|evm.model.AC_000162.1.507 Q9UNS1 TIM_HUMAN 87.182 0.996705 1.00497 TIMELESS - Protein timeless homolog - Homo sapiens (Human) - TIMELESS gene Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:9856465, PubMed:17141802, PubMed:17296725, PubMed:23418588, PubMed:26344098). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:9856465). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). Taurus_UMD|evm.model.AC_000162.1.508 Q13790 APOF_HUMAN 31.395 0.631373 0.782209 APOF - Apolipoprotein F precursor - Homo sapiens (Human) - APOF gene Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII. Taurus_UMD|evm.model.AC_000162.1.509 O02799 STAT2_PIG 83.565 0.752858 1.31597 STAT2 - Signal transducer and activator of transcription 2 - Sus scrofa (Pig) - STAT2 gene Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively. Taurus_UMD|evm.model.AC_000162.1.510 Q9N2H9 IL23A_PIG 86.979 0.984456 1 IL23A - Interleukin-23 subunit alpha precursor - Sus scrofa (Pig) - IL23A gene Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity). Taurus_UMD|evm.model.AC_000162.1.511 Q504Q3 PAN2_HUMAN 97.671 0.998332 0.997504 PAN2 - PAN2-PAN3 deadenylation complex catalytic subunit PAN2 - Homo sapiens (Human) - PAN2 gene Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. Taurus_UMD|evm.model.AC_000162.1.512 Q9Y2B0 CNPY2_HUMAN 98.901 0.989071 1.00549 CNPY2 - Protein canopy homolog 2 precursor - Homo sapiens (Human) - CNPY2 gene Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. Taurus_UMD|evm.model.AC_000162.1.513 Q29RK1 CISY_BOVIN 100.000 0.995717 1.00215 CS - Citrate synthase, mitochondrial precursor - Bos taurus (Bovine) - CS gene mitochondrial matrix, citrate (Si)-synthase activity, carbohydrate metabolic process, tricarboxylic acid cycle Taurus_UMD|evm.model.AC_000162.1.514 Q96MF6 CQ10A_HUMAN 93.103 0.985366 0.82996 COQ10A - Coenzyme Q-binding protein COQ10 homolog A, mitochondrial precursor - Homo sapiens (Human) - COQ10A gene Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable). Taurus_UMD|evm.model.AC_000162.1.515 Q8NB46 ANR52_HUMAN 99.442 0.998143 1.00093 ANKRD52 - Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C - Homo sapiens (Human) - ANKRD52 gene Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Taurus_UMD|evm.model.AC_000162.1.516 Q6ZMH5 S39A5_HUMAN 83.549 0.883797 1.13148 SLC39A5 - Zinc transporter ZIP5 precursor - Homo sapiens (Human) - SLC39A5 gene May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport (By similarity). Seems to play a central role in controlling organismal zinc status (By similarity). Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Plays a role in eye development (PubMed:24891338). Taurus_UMD|evm.model.AC_000162.1.517 A6QLK2 SOSB1_BOVIN 100.000 0.990566 1.00474 NABP2 - SOSS complex subunit B1 - Bos taurus (Bovine) - NABP2 gene Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). Taurus_UMD|evm.model.AC_000162.1.518 Q5R7T5 RNF41_PONAB 91.483 0.993151 0.921136 RNF41 - E3 ubiquitin-protein ligase NRDP1 - Pongo abelii (Sumatran orangutan) - RNF41 gene Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. Taurus_UMD|evm.model.AC_000162.1.519 Q8TAQ2 SMRC2_HUMAN 93.323 0.94862 1.07414 SMARCC2 - SWI/SNF complex subunit SMARCC2 - Homo sapiens (Human) - SMARCC2 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). Taurus_UMD|evm.model.AC_000162.1.520 Q64119 MYL6_RAT 99.333 0.919753 1.07285 Myl6 - Myosin light polypeptide 6 - Rattus norvegicus (Rat) - Myl6 gene Regulatory light chain of myosin. Does not bind calcium. Taurus_UMD|evm.model.AC_000162.1.521 P14649 MYL6B_HUMAN 78.673 0.990566 1.01923 MYL6B - Myosin light chain 6B - Homo sapiens (Human) - MYL6B gene Regulatory light chain of myosin. Does not bind calcium. Taurus_UMD|evm.model.AC_000162.1.522 Q5RAG2 ESYT1_PONAB 90.191 0.99187 1.00272 ESYT1 - Extended synaptotagmin-1 - Pongo abelii (Sumatran orangutan) - ESYT1 gene Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Taurus_UMD|evm.model.AC_000162.1.523 Q9UQ80 PA2G4_HUMAN 99.732 0.434072 2.17513 PA2G4 - Proliferation-associated protein 2G4 - Homo sapiens (Human) - PA2G4 gene May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). Taurus_UMD|evm.model.AC_000162.1.524 P21860 ERBB3_HUMAN 93.661 0.997756 0.996274 ERBB3 - Receptor tyrosine-protein kinase erbB-3 precursor - Homo sapiens (Human) - ERBB3 gene Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). Taurus_UMD|evm.model.AC_000162.1.525 P62856 RS26_RAT 100.000 0.982759 1.0087 Rps26 - 40S ribosomal protein S26 - Rattus norvegicus (Rat) - Rps26 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, mRNA binding, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000162.1.526 Q9H2S9 IKZF4_HUMAN 98.106 0.974122 0.924786 IKZF4 - Zinc finger protein Eos - Homo sapiens (Human) - IKZF4 gene DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity). Taurus_UMD|evm.model.AC_000162.1.527 P51687 SUOX_HUMAN 85.138 0.992701 1.0055 SUOX - Sulfite oxidase, mitochondrial precursor - Homo sapiens (Human) - SUOX gene mitochondrial matrix, mitochondrion, heme binding, molybdopterin cofactor binding, sulfite oxidase activity, sulfide oxidation, using sulfide:quinone oxidoreductase, sulfur compound metabolic process Taurus_UMD|evm.model.AC_000162.1.528 Q5RBG1 RAB5B_PONAB 99.535 0.990741 1.00465 RAB5B - Ras-related protein Rab-5B - Pongo abelii (Sumatran orangutan) - RAB5B gene Protein transport. Probably involved in vesicular traffic. Taurus_UMD|evm.model.AC_000162.1.529 P97377 CDK2_MOUSE 98.844 0.994236 1.00289 Cdk2 - Cyclin-dependent kinase 2 - Mus musculus (Mouse) - Cdk2 gene Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (PubMed:23853094). Phosphorylates CDK2AP2 (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (By similarity). Taurus_UMD|evm.model.AC_000162.1.530 Q06154 PMEL_BOVIN 99.479 0.99481 0.890601 PMEL - Melanocyte protein PMEL precursor - Bos taurus (Bovine) - PMEL gene Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures (By similarity). Taurus_UMD|evm.model.AC_000162.1.531 A0JN54 DGKA_BOVIN 100.000 0.945806 1.05586 DGKA - Diacylglycerol kinase alpha - Bos taurus (Bovine) - DGKA gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group. Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol. Taurus_UMD|evm.model.AC_000162.1.532 A6QPH1 PYM1_BOVIN 100.000 0.990196 1.00493 PYM1 - Partner of Y14 and mago - Bos taurus (Bovine) - PYM1 gene Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity). Taurus_UMD|evm.model.AC_000162.1.533 Q9CPX9 APC11_MOUSE 60.811 0.972973 0.880952 Anapc11 - Anaphase-promoting complex subunit 11 - Mus musculus (Mouse) - Anapc11 gene Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). Taurus_UMD|evm.model.AC_000162.1.534 Q99542 MMP19_HUMAN 85.628 0.982 0.984252 MMP19 - Matrix metalloproteinase-19 precursor - Homo sapiens (Human) - MMP19 gene Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. Taurus_UMD|evm.model.AC_000162.1.535 Q6DFQ7 TM198_XENTR 53.666 0.938547 1.04678 tmem198 - Transmembrane protein 198 - Xenopus tropicalis (Western clawed frog) - tmem198 gene Promotes lrp6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of lrp6 further enhancing its activity. Required for neural crest formation. Taurus_UMD|evm.model.AC_000162.1.536 Q95J56 DJC14_BOVIN 100.000 0.997143 1.00143 DNAJC14 - DnaJ homolog subfamily C member 14 - Bos taurus (Bovine) - DNAJC14 gene Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity). Promotes cleavage of pestivirus polyprotein. Taurus_UMD|evm.model.AC_000162.1.537 Q5E972 ORML2_BOVIN 100.000 0.987013 1.00654 ORMDL2 - ORM1-like protein 2 - Bos taurus (Bovine) - ORMDL2 gene Negative regulator of sphingolipid synthesis. Taurus_UMD|evm.model.AC_000162.1.538 Q5R4V4 SARNP_PONAB 97.143 0.990521 1.00476 SARNP - SAP domain-containing ribonucleoprotein - Pongo abelii (Sumatran orangutan) - SARNP gene Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity). Taurus_UMD|evm.model.AC_000162.1.539 O95390 GDF11_HUMAN 99.410 0.968481 0.857494 GDF11 - Growth/differentiation factor 11 precursor - Homo sapiens (Human) - GDF11 gene Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634). Taurus_UMD|evm.model.AC_000162.1.540 Q9XSK2 CD63_BOVIN 100.000 0.991597 1.00422 CD63 - CD63 antigen - Bos taurus (Bovine) - CD63 gene Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli (By similarity). Taurus_UMD|evm.model.AC_000162.1.541 Q27979 RDH5_BOVIN 100.000 0.99373 1.00314 RDH5 - Retinol dehydrogenase 5 - Bos taurus (Bovine) - RDH5 gene Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:7544779, PubMed:7836368, PubMed:9654122). Has no activity towards all-trans retinal (PubMed:9654122). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE) (By similarity). Also recognizes steroids (androsterone, androstanediol) as its substrates (By similarity). Taurus_UMD|evm.model.AC_000162.1.542 Q5R7L8 BL1S1_PONAB 100.000 0.984127 0.823529 BLOC1S1 - Biogenesis of lysosome-related organelles complex 1 subunit 1 - Pongo abelii (Sumatran orangutan) - BLOC1S1 gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. The BORC complex is most probably associated with the cytosolic face of lysosomes, may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Taurus_UMD|evm.model.AC_000162.1.543 Q13683 ITA7_HUMAN 93.805 0.757576 0.251482 ITGA7 - Integrin alpha-7 precursor - Homo sapiens (Human) - ITGA7 gene Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Taurus_UMD|evm.model.AC_000162.1.544 Q13683 ITA7_HUMAN 94.118 0.852071 0.286198 ITGA7 - Integrin alpha-7 precursor - Homo sapiens (Human) - ITGA7 gene Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Taurus_UMD|evm.model.AC_000162.1.545 Q13683 ITA7_HUMAN 93.073 0.996454 0.477561 ITGA7 - Integrin alpha-7 precursor - Homo sapiens (Human) - ITGA7 gene Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Taurus_UMD|evm.model.AC_000162.1.546 Q6UX53 MET7B_HUMAN 85.650 0.906122 1.0041 METTL7B - Methyltransferase-like protein 7B precursor - Homo sapiens (Human) - METTL7B gene Probable methyltransferase. Taurus_UMD|evm.model.AC_000162.1.547 Q8NGE2 O2AP1_HUMAN 82.278 0.957317 0.530744 OR2AP1 - Olfactory receptor 2AP1 - Homo sapiens (Human) - OR2AP1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.548 Q56JY4 TOM6_BOVIN 97.297 0.973333 1.01351 TOMM6 - Mitochondrial import receptor subunit TOM6 homolog - Bos taurus (Bovine) - TOMM6 gene mitochondrion Taurus_UMD|evm.model.AC_000162.1.549 A6NDL8 O6C68_HUMAN 68.235 0.944134 0.573718 OR6C68 - Olfactory receptor 6C68 - Homo sapiens (Human) - OR6C68 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.550 Q9NZP2 OR6C2_HUMAN 72.549 0.987013 0.49359 OR6C2 - Olfactory receptor 6C2 - Homo sapiens (Human) - OR6C2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.551 Q8NGE1 OR6C4_HUMAN 91.195 0.981366 0.521036 OR6C4 - Olfactory receptor 6C4 - Homo sapiens (Human) - OR6C4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.552 Q9NZP2 OR6C2_HUMAN 72.109 0.986532 0.951923 OR6C2 - Olfactory receptor 6C2 - Homo sapiens (Human) - OR6C2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.555 A6NDL8 O6C68_HUMAN 75.127 0.994924 0.63141 OR6C68 - Olfactory receptor 6C68 - Homo sapiens (Human) - OR6C68 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.556 A6NDL8 O6C68_HUMAN 79.032 0.991935 0.397436 OR6C68 - Olfactory receptor 6C68 - Homo sapiens (Human) - OR6C68 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.559 Q96RD1 OR6C1_HUMAN 81.229 0.996587 0.939103 OR6C1 - Olfactory receptor 6C1 - Homo sapiens (Human) - OR6C1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.561 A6NDL8 O6C68_HUMAN 81.452 0.991935 0.397436 OR6C68 - Olfactory receptor 6C68 - Homo sapiens (Human) - OR6C68 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.562 A6NM76 O6C76_HUMAN 88.144 0.984694 0.628205 OR6C76 - Olfactory receptor 6C76 - Homo sapiens (Human) - OR6C76 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.563 Q9NZP0 OR6C3_HUMAN 78.065 0.96587 0.942122 OR6C3 - Olfactory receptor 6C3 - Homo sapiens (Human) - OR6C3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.564 Q9NZP0 OR6C3_HUMAN 79.355 0.98 0.96463 OR6C3 - Olfactory receptor 6C3 - Homo sapiens (Human) - OR6C3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.565 A6NM76 O6C76_HUMAN 72.973 0.996622 0.948718 OR6C76 - Olfactory receptor 6C76 - Homo sapiens (Human) - OR6C76 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.566 Q8NGE1 OR6C4_HUMAN 69.381 0.977636 1.01294 OR6C4 - Olfactory receptor 6C4 - Homo sapiens (Human) - OR6C4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.567 Q9NZP0 OR6C3_HUMAN 76.129 0.933993 0.974277 OR6C3 - Olfactory receptor 6C3 - Homo sapiens (Human) - OR6C3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000162.1.569 Q9HD90 NDF4_HUMAN 91.239 0.993958 1 NEUROD4 - Neurogenic differentiation factor 4 - Homo sapiens (Human) - NEUROD4 gene Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity). Taurus_UMD|evm.model.AC_000162.1.570 A2RU30 TESP1_HUMAN 80.806 0.861436 1.14971 TESPA1 - Protein TESPA1 - Homo sapiens (Human) - TESPA1 gene Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. Taurus_UMD|evm.model.AC_000162.1.571 Q5RB89 NET4_PONAB 85.191 0.996599 0.936306 NTN4 - Netrin-4 precursor - Pongo abelii (Sumatran orangutan) - NTN4 gene May play an important role in neural, kidney and vascular development. Taurus_UMD|evm.model.AC_000162.1.572 P62321 RUXF_XENLA 100.000 0.674603 1.46512 snrpf - Small nuclear ribonucleoprotein F - Xenopus laevis (African clawed frog) - snrpf gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. Taurus_UMD|evm.model.AC_000162.1.573 Q8CDN8 CCD38_MOUSE 74.229 0.951304 1.02131 Ccdc38 - Coiled-coil domain-containing protein 38 - Mus musculus (Mouse) - Ccdc38 gene centrosome Taurus_UMD|evm.model.AC_000162.1.574 A5PJV3 HUTI_BOVIN 100.000 0.995316 1.00235 AMDHD1 - Probable imidazolonepropionase - Bos taurus (Bovine) - AMDHD1 gene imidazolonepropionase activity, histidine catabolic process Taurus_UMD|evm.model.AC_000162.1.575 A7YWP4 HUTH_BOVIN 100.000 0.99696 1.00152 HAL - Histidine ammonia-lyase - Bos taurus (Bovine) - HAL gene ammonia-lyase activity, histidine ammonia-lyase activity, histidine catabolic process Taurus_UMD|evm.model.AC_000162.1.576 Q3SZH7 LKHA4_BOVIN 100.000 0.996732 1.00164 LTA4H - Leukotriene A-4 hydrolase - Bos taurus (Bovine) - LTA4H gene Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the proinflammatory mediator leukotriene B4 (LTB4). Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides. In addition to its proinflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions. Taurus_UMD|evm.model.AC_000162.1.577 P41970 ELK3_HUMAN 93.857 0.995037 0.990172 ELK3 - ETS domain-containing protein Elk-3 - Homo sapiens (Human) - ELK3 gene May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. Taurus_UMD|evm.model.AC_000162.1.578 Q00537 CDK17_HUMAN 99.044 0.996183 1.00191 CDK17 - Cyclin-dependent kinase 17 - Homo sapiens (Human) - CDK17 gene May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Taurus_UMD|evm.model.AC_000162.1.579 Q96N23 CFA54_HUMAN 80.199 0.794904 0.773256 CFAP54 - Cilia- and flagella-associated protein 54 - Homo sapiens (Human) - CFAP54 gene Required for assembly and function of cilia and flagella. Taurus_UMD|evm.model.AC_000162.1.580 Q3B7M6 NEDD1_BOVIN 98.032 0.973592 0.861912 NEDD1 - Protein NEDD1 - Bos taurus (Bovine) - NEDD1 gene Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. Taurus_UMD|evm.model.AC_000162.1.584 O60814 H2B1K_HUMAN 92.500 0.881481 1.07143 H2BC12 - Histone H2B type 1-K - Homo sapiens (Human) - H2BC12 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000162.1.585 P42166 LAP2A_HUMAN 95.161 0.406593 0.65562 TMPO - Lamina-associated polypeptide 2, isoform alpha - Homo sapiens (Human) - TMPO gene May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1. Taurus_UMD|evm.model.AC_000162.1.586 P12234 MPCP_BOVIN 96.961 0.994475 1 SLC25A3 - Phosphate carrier protein, mitochondrial precursor - Bos taurus (Bovine) - SLC25A3 gene Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP). Taurus_UMD|evm.model.AC_000162.1.587 A2VE53 IKIP_BOVIN 96.565 0.436455 1.71347 IKBIP - Inhibitor of nuclear factor kappa-B kinase-interacting protein - Bos taurus (Bovine) - IKBIP gene Target of p53/TP53 with pro-apoptotic function. Taurus_UMD|evm.model.AC_000162.1.588 O14727 APAF_HUMAN 90.472 0.9984 1.0016 APAF1 - Apoptotic protease-activating factor 1 - Homo sapiens (Human) - APAF1 gene Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. Taurus_UMD|evm.model.AC_000162.1.589 Q9NZ56 FMN2_HUMAN 82.456 0.990741 0.125436 FMN2 - Formin-2 - Homo sapiens (Human) - FMN2 gene Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:22330775, PubMed:21730168). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:22330775, PubMed:21730168). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). Taurus_UMD|evm.model.AC_000162.1.590 Q8BIZ1 ANS1B_MOUSE 98.681 0.932238 0.386815 Anks1b - Ankyrin repeat and sterile alpha motif domain-containing protein 1B - Mus musculus (Mouse) - Anks1b gene Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Taurus_UMD|evm.model.AC_000162.1.591 Q7Z6G8 ANS1B_HUMAN 87.129 0.905405 0.177885 ANKS1B - Ankyrin repeat and sterile alpha motif domain-containing protein 1B - Homo sapiens (Human) - ANKS1B gene Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Taurus_UMD|evm.model.AC_000162.1.593 Q7Z6G8 ANS1B_HUMAN 95.192 0.741007 0.111378 ANKS1B - Ankyrin repeat and sterile alpha motif domain-containing protein 1B - Homo sapiens (Human) - ANKS1B gene Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Taurus_UMD|evm.model.AC_000162.1.594 Q5R4T8 DCA13_PONAB 53.973 0.985185 0.606742 DCAF13 - DDB1- and CUL4-associated factor 13 - Pongo abelii (Sumatran orangutan) - DCAF13 gene Possible role in ribosomal RNA processing. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). Taurus_UMD|evm.model.AC_000162.1.595 Q8TC56 FA71B_HUMAN 62.963 0.623529 0.280992 FAM71B - Protein FAM71B - Homo sapiens (Human) - FAM71B gene May be involved in RNA biogenesis. Taurus_UMD|evm.model.AC_000162.1.596 Q7Z6G8 ANS1B_HUMAN 98.421 0.87935 0.345353 ANKS1B - Ankyrin repeat and sterile alpha motif domain-containing protein 1B - Homo sapiens (Human) - ANKS1B gene Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Taurus_UMD|evm.model.AC_000162.1.597 Q5T7W7 TSTD2_HUMAN 48.649 0.985401 0.265504 TSTD2 - Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 - Homo sapiens (Human) - TSTD2 gene Taurus_UMD|evm.model.AC_000162.1.598 A0JNW5 UH1BL_HUMAN 90.604 0.991144 1.00273 UHRF1BP1L - UHRF1-binding protein 1-like - Homo sapiens (Human) - UHRF1BP1L gene cytosol, early endosome, GARP complex binding, protein homodimerization activity Taurus_UMD|evm.model.AC_000162.1.599 Q9GZN1 ARP6_HUMAN 94.444 0.994709 0.954545 ACTR6 - Actin-related protein 6 - Homo sapiens (Human) - ACTR6 gene nucleus, Swr1 complex, nucleosome binding, histone exchange Taurus_UMD|evm.model.AC_000162.1.600 Q6P3W7 SCYL2_HUMAN 92.896 0.997778 0.968784 SCYL2 - SCY1-like protein 2 - Homo sapiens (Human) - SCYL2 gene Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system (Probable). A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (PubMed:15809293, PubMed:16914521). By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (By similarity). Taurus_UMD|evm.model.AC_000162.1.601 Q8NDX2 VGLU3_HUMAN 93.729 0.99661 1.0017 SLC17A8 - Vesicular glutamate transporter 3 - Homo sapiens (Human) - SLC17A8 gene Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Taurus_UMD|evm.model.AC_000162.1.602 Q3SZL0 NR1H4_BOVIN 98.971 0.995893 1.01037 NR1H4 - Bile acid receptor - Bos taurus (Bovine) - NR1H4 gene Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity. In the liver activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs). Activates transcription of the repressor MAFG (involved in regulation of BA synthesis). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine). In the intestine activates FGF19 expression and secretion leading to hepatic CYP7A1 repression. The function also involves the coordinated induction of hepatic KLB/beta-klotho expression. Regulates transcription of liver UGT2B4 and SULT2A1 involved in BA detoxification; binding to the UGT2B4 promoter seems to imply a monomeric transactivation independent of RXRA. Modulates lipid homeostasis by activating liver NR0B2/SHP-mediated repression of SREBF1 (involved in de novo lipogenesis), expression of PLTP (involved in HDL formation), SCARB1 (involved in HDL hepatic uptake), APOE, APOC1, APOC4, PPARA (involved in beta-oxidation of fatty acids), VLDLR and SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly). Increases expression of APOC2 (promoting lipoprotein lipase activity implicated in triglyceride clearance). Transrepresses APOA1 involving a monomeric competition with NR2A1 for binding to a DR1 element. Also reduces triglyceride clearance by inhibiting expression of ANGPTL3 and APOC3 (both involved in inhibition of lipoprotein lipase). Involved in glucose homeostasis by modulating hepatic gluconeogenesis through activation of NR0B2/SHP-mediated repression of respective genes. Modulates glycogen synthesis (inducing phosphorylation of glycogen synthase kinase-3). Modulates glucose-stimulated insulin secretion and is involved in insulin resistance. Involved in intestinal innate immunity. Plays a role in protecting the distal small intestine against bacterial overgrowth and preservation of the epithelial barrier. Down-regulates inflammatory cytokine expression in several types of immune cells including macrophages and mononuclear cells. Mediates trans-repression of TLR4-induced cytokine expression; the function seems to require its sumoylation and prevents N-CoR nuclear receptor corepressor clearance from target genes such as IL1B and NOS2. Involved in the TLR9-mediated protective mechanism in intestinal inflammation. Plays an anti-inflammatory role in liver inflammation; proposed to inhibit proinflammatory (but not antiapoptotic) NF-kappa-B signaling. Taurus_UMD|evm.model.AC_000162.1.603 P03709 FI_LAMBD 43.750 0.95614 0.863636 Fi - DNA-packaging protein FI - Escherichia phage lambda - Fi gene Stimulates the interaction of procapsid with the terminase-DNA complex, thereby increasing the overall rate of DNA packaging. Before packaging, it likely coats the surface of the procapsid through binding mediated by c-terminal domain. FI presumably dissociates from the capsid once it inflates upon DNA packaging, and is not present in the mature virion. Taurus_UMD|evm.model.AC_000162.1.604 Q86XJ1 GA2L3_HUMAN 83.453 0.997106 0.995677 GAS2L3 - GAS2-like protein 3 - Homo sapiens (Human) - GAS2L3 gene Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. Taurus_UMD|evm.model.AC_000162.1.606 Q32M45 ANO4_HUMAN 98.534 0.997908 1.00105 ANO4 - Anoctamin-4 - Homo sapiens (Human) - ANO4 gene Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity). Taurus_UMD|evm.model.AC_000162.1.607 Q8N695 SC5A8_HUMAN 89.198 0.996732 1.00328 SLC5A8 - Sodium-coupled monocarboxylate transporter 1 - Homo sapiens (Human) - SLC5A8 gene Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Taurus_UMD|evm.model.AC_000162.1.608 O75691 UTP20_HUMAN 89.274 0.99928 0.997846 UTP20 - Small subunit processome component 20 homolog - Homo sapiens (Human) - UTP20 gene Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. Taurus_UMD|evm.model.AC_000162.1.609 Q2YDM1 ARL1_BOVIN 100.000 0.989011 1.00552 ARL1 - ADP-ribosylation factor-like protein 1 - Bos taurus (Bovine) - ARL1 gene GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity). Taurus_UMD|evm.model.AC_000162.1.610 P13182 CX6A1_BOVIN 96.330 0.981818 1.00917 COX6A1 - Cytochrome c oxidase subunit 6A1, mitochondrial precursor - Bos taurus (Bovine) - COX6A1 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000162.1.611 Q1RML4 SPIC_BOVIN 100.000 0.991968 1.00403 SPIC - Transcription factor Spi-C - Bos taurus (Bovine) - SPIC gene Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity). Taurus_UMD|evm.model.AC_000162.1.612 Q00872 MYPC1_HUMAN 88.579 0.933002 1.0596 MYBPC1 - Myosin-binding protein C, slow-type - Homo sapiens (Human) - MYBPC1 gene Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31264822, PubMed:31025394). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. Taurus_UMD|evm.model.AC_000162.1.613 Q1LZE6 CHPT1_BOVIN 99.746 0.984962 0.982759 CHPT1 - Cholinephosphotransferase 1 - Bos taurus (Bovine) - CHPT1 gene Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes. Taurus_UMD|evm.model.AC_000162.1.614 Q3T0E2 SYCP3_BOVIN 99.087 0.810409 1.19556 SYCP3 - Synaptonemal complex protein 3 - Bos taurus (Bovine) - SYCP3 gene Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2. Taurus_UMD|evm.model.AC_000162.1.615 Q3T906 GNPTA_HUMAN 88.574 0.896047 1.08758 GNPTAB - N-acetylglucosamine-1-phosphotransferase subunits alpha/beta precursor - Homo sapiens (Human) - GNPTAB gene Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. Taurus_UMD|evm.model.AC_000162.1.616 Q9DC58 DRAM1_MOUSE 83.544 0.985646 0.878151 Dram1 - DNA damage-regulated autophagy modulator protein 1 - Mus musculus (Mouse) - Dram1 gene Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy (By similarity). Taurus_UMD|evm.model.AC_000162.1.617 Q6AYL5 SF3B4_RAT 98.315 0.86165 0.971698 Sf3b4 - Splicing factor 3B subunit 4 - Rattus norvegicus (Rat) - Sf3b4 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Taurus_UMD|evm.model.AC_000162.1.618 Q05B58 WASC3_BOVIN 99.485 0.989744 1.00515 WASHC3 - WASH complex subunit 3 - Bos taurus (Bovine) - WASHC3 gene Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Taurus_UMD|evm.model.AC_000162.1.619 Q8NFH4 NUP37_HUMAN 86.810 0.99359 0.957055 NUP37 - Nucleoporin Nup37 - Homo sapiens (Human) - NUP37 gene Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. Taurus_UMD|evm.model.AC_000162.1.620 F1MF21 PARI_BOVIN 85.052 0.996109 0.883162 PARPBP - PCNA-interacting partner - Bos taurus (Bovine) - PARPBP gene Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect (By similarity). Taurus_UMD|evm.model.AC_000162.1.621 P20382 MCH_HUMAN 91.515 0.987952 1.00606 PMCH - Pro-MCH precursor - Homo sapiens (Human) - PMCH gene MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation. Taurus_UMD|evm.model.AC_000162.1.622 Q4R6V2 TCPE_MACFA 60.976 0.972569 0.74122 CCT5 - T-complex protein 1 subunit epsilon - Macaca fascicularis (Crab-eating macaque) - CCT5 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Taurus_UMD|evm.model.AC_000162.1.623 P07455 IGF1_BOVIN 100.000 0.987097 1.00649 IGF1 - Insulin-like growth factor I precursor - Bos taurus (Bovine) - IGF1 gene The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity). Taurus_UMD|evm.model.AC_000162.1.625 Q2KIH7 PH4H_BOVIN 100.000 0.995575 1.00222 PAH - Phenylalanine-4-hydroxylase - Bos taurus (Bovine) - PAH gene Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Taurus_UMD|evm.model.AC_000162.1.626 Q02067 ASCL1_MOUSE 97.661 0.772727 0.952381 Ascl1 - Achaete-scute homolog 1 - Mus musculus (Mouse) - Ascl1 gene Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways (PubMed:24243019). Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes (PubMed:20107439, PubMed:24243019, PubMed:27281220). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS (PubMed:8217843). Essential for the generation of olfactory and autonomic neurons (PubMed:8221886). Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation (PubMed:16020526, PubMed:17728344). Involved in the regulation of neuroendocrine cell development in the glandular stomach (PubMed:18173746). Taurus_UMD|evm.model.AC_000162.1.627 Q9BL19 RL17_CAEEL 81.250 0.607843 0.272727 rpl-17 - 60S ribosomal protein L17 - Caenorhabditis elegans - rpl-17 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000162.1.628 Q8WWQ8 STAB2_HUMAN 84.314 0.999216 0.999608 STAB2 - Stabilin-2 precursor - Homo sapiens (Human) - STAB2 gene Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS. Taurus_UMD|evm.model.AC_000162.1.629 Q86UY8 NT5D3_HUMAN 95.437 0.959707 0.99635 NT5DC3 - 5'-nucleotidase domain-containing protein 3 - Homo sapiens (Human) - NT5DC3 gene receptor complex, 5'-nucleotidase activity Taurus_UMD|evm.model.AC_000162.1.630 Q6P2S7 TTC41_HUMAN 68.493 0.995134 0.935508 TTC41P - Putative tetratricopeptide repeat protein 41 - Homo sapiens (Human) - TTC41P gene Taurus_UMD|evm.model.AC_000162.1.632 Q95M18 ENPL_BOVIN 100.000 0.997516 1.00124 HSP90B1 - Endoplasmin precursor - Bos taurus (Bovine) - HSP90B1 gene Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (By similarity). Taurus_UMD|evm.model.AC_000162.1.633 Q69YU5 BWNIN_HUMAN 84.615 0.888889 1.01408 BRAWNIN - Protein BRAWNIN - Homo sapiens (Human) - BRAWNIN gene Essential for mitochondrial respiratory chain complex III (CIII) assembly and stability. Taurus_UMD|evm.model.AC_000162.1.634 Q13569 TDG_HUMAN 91.872 0.883516 1.10976 TDG - G/T mismatch-specific thymine DNA glycosylase - Homo sapiens (Human) - TDG gene DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. Taurus_UMD|evm.model.AC_000162.1.635 Q2HJ96 GL8D2_BOVIN 100.000 0.994302 1.00286 GLT8D2 - Glycosyltransferase 8 domain-containing protein 2 - Bos taurus (Bovine) - GLT8D2 gene Golgi apparatus Taurus_UMD|evm.model.AC_000162.1.636 Q9Y5Z7 HCFC2_HUMAN 94.823 0.997478 1.00126 HCFC2 - Host cell factor 2 - Homo sapiens (Human) - HCFC2 gene cytoplasm, cytosol, histone methyltransferase complex, nuclear body, nucleoplasm, nucleus, plasma membrane, transcription coactivator activity, chromatin remodeling, negative regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000162.1.637 Q32KW0 NFYB_BOVIN 100.000 0.990385 1.00483 NFYB - Nuclear transcription factor Y subunit beta - Bos taurus (Bovine) - NFYB gene Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors (By similarity). Taurus_UMD|evm.model.AC_000162.1.638 A6QPC8 EID3_BOVIN 100.000 0.994737 1.00264 EID3 - EP300-interacting inhibitor of differentiation 3 - Bos taurus (Bovine) - EID3 gene Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). Taurus_UMD|evm.model.AC_000162.1.639 O62768 TRXR1_BOVIN 100.000 0.813115 1.22244 TXNRD1 - Thioredoxin reductase 1, cytoplasmic - Bos taurus (Bovine) - TXNRD1 gene cytoplasm, cytosol, mitochondrion, thioredoxin-disulfide reductase activity, cell redox homeostasis Taurus_UMD|evm.model.AC_000162.1.642 Q9NPF2 CHSTB_HUMAN 99.038 0.99361 0.889205 CHST11 - Carbohydrate sulfotransferase 11 - Homo sapiens (Human) - CHST11 gene Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. Taurus_UMD|evm.model.AC_000162.1.643 Q4R335 S41A2_MACFA 94.939 0.996516 1.00175 SLC41A2 - Solute carrier family 41 member 2 - Macaca fascicularis (Crab-eating macaque) - SLC41A2 gene Acts as a plasma-membrane magnesium transporter. Taurus_UMD|evm.model.AC_000162.1.645 Q2TBJ0 CL045_BOVIN 100.000 0.989637 1.00521 NOPCHAP1 - NOP protein chaperone 1 - Bos taurus (Bovine) - NOPCHAP1 gene Client-loading PAQosome/R2TP complex cofactor that selects NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP) assembly. Acts as a bridge between NOP58 and the R2TP complex via RUVBL1:RUVBL2. Taurus_UMD|evm.model.AC_000162.1.646 Q3SY69 AL1L2_HUMAN 94.800 0.997835 1.00108 ALDH1L2 - Mitochondrial 10-formyltetrahydrofolate dehydrogenase - Homo sapiens (Human) - ALDH1L2 gene extracellular exosome, mitochondrial matrix, mitochondrion, nucleoplasm, aldehyde dehydrogenase (NAD+) activity, formyltetrahydrofolate dehydrogenase activity, folic acid metabolic process Taurus_UMD|evm.model.AC_000162.1.647 Q2M389 WASC4_HUMAN 98.892 0.998296 1.00085 WASHC4 - WASH complex subunit 4 - Homo sapiens (Human) - WASHC4 gene Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Taurus_UMD|evm.model.AC_000162.1.648 Q8NEU8 DP13B_HUMAN 93.373 0.996983 0.998494 APPL2 - DCC-interacting protein 13-beta - Homo sapiens (Human) - APPL2 gene Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:24879834). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (PubMed:24879834) (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:19433865) (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). Taurus_UMD|evm.model.AC_000162.1.651 O60285 NUAK1_HUMAN 94.127 0.996983 1.00303 NUAK1 - NUAK family SNF1-like kinase 1 - Homo sapiens (Human) - NUAK1 gene Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). Taurus_UMD|evm.model.AC_000162.1.652 Q07065 CKAP4_HUMAN 79.236 0.99661 0.980066 CKAP4 - Cytoskeleton-associated protein 4 - Homo sapiens (Human) - CKAP4 gene Mediates the anchoring of the endoplasmic reticulum to microtubules. Taurus_UMD|evm.model.AC_000162.1.653 A7Z033 T11L2_BOVIN 100.000 0.996154 1.00193 TCP11L2 - T-complex protein 11-like protein 2 - Bos taurus (Bovine) - TCP11L2 gene signal transduction Taurus_UMD|evm.model.AC_000162.1.654 Q9NW08 RPC2_HUMAN 96.911 0.9982 0.980583 POLR3B - DNA-directed RNA polymerase III subunit RPC2 - Homo sapiens (Human) - POLR3B gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Taurus_UMD|evm.model.AC_000162.1.657 Q33E94 RFX4_HUMAN 98.639 0.997283 1.00136 RFX4 - Transcription factor RFX4 - Homo sapiens (Human) - RFX4 gene Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development. Taurus_UMD|evm.model.AC_000162.1.658 Q9NVN3 RIC8B_HUMAN 91.607 0.996435 1.07885 RIC8B - Synembryn-B - Homo sapiens (Human) - RIC8B gene Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction. Taurus_UMD|evm.model.AC_000162.1.659 Q3SYV1 TM263_BOVIN 100.000 0.782313 1.26724 TMEM263 - Transmembrane protein 263 - Bos taurus (Bovine) - TMEM263 gene Taurus_UMD|evm.model.AC_000162.1.660 Q16526 CRY1_HUMAN 89.179 0.532831 1.58532 CRY1 - Cryptochrome-1 - Homo sapiens (Human) - CRY1 gene Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-ARNTL/BMAL1 independently of PER proteins and is found at CLOCK-ARNTL/BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-ARNTL/BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-ARNTL/BMAL1 induced transcription of ATF4, MTA1, KLF10 and NAMPT (By similarity). May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Inhibits hepatic gluconeogenesis by decreasing nuclear FOXO1 levels that downregulates gluconeogenic gene expression (By similarity). Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4 (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Plays an essential role in the generation of circadian rhythms in the retina (By similarity). Represses the transcriptional activity of NR1I2 (By similarity). Taurus_UMD|evm.model.AC_000162.1.661 P68002 VDAC2_BOVIN 97.959 0.864307 1.15306 VDAC2 - Voltage-dependent anion-selective channel protein 2 - Bos taurus (Bovine) - VDAC2 gene Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (By similarity). Binding of ceramide promotes the Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (By similarity). Taurus_UMD|evm.model.AC_000162.1.663 Q2HJ56 PWP1_BOVIN 100.000 0.996008 1.002 PWP1 - Periodic tryptophan protein 1 homolog - Bos taurus (Bovine) - PWP1 gene Chromatin-associated factor that regulates transcription (By similarity). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (By similarity). Regulates the epigenetic status of rDNA (By similarity). Taurus_UMD|evm.model.AC_000162.1.664 Q9UKN5 PRDM4_HUMAN 97.253 0.997506 1.00125 PRDM4 - PR domain zinc finger protein 4 - Homo sapiens (Human) - PRDM4 gene May function as a transcription factor involved in cell differentiation. Taurus_UMD|evm.model.AC_000162.1.665 Q9JJR7 ASCL3_MOUSE 70.769 0.378698 0.971264 Ascl3 - Achaete-scute homolog 3 - Mus musculus (Mouse) - Ascl3 gene Transcriptional repressor. Inhibits myogenesis. Taurus_UMD|evm.model.AC_000162.1.666 Q5E9T9 RTCB_BOVIN 100.000 0.996047 1.00198 RTCB - RNA-splicing ligase RtcB homolog - Bos taurus (Bovine) - RTCB gene Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. Taurus_UMD|evm.model.AC_000162.1.667 Q8NFQ6 BPIFC_HUMAN 83.084 0.932 0.986193 BPIFC - BPI fold-containing family C protein precursor - Homo sapiens (Human) - BPIFC gene extracellular space, lipopolysaccharide binding, phospholipid binding Taurus_UMD|evm.model.AC_000162.1.668 Q2T9S7 FBX7_BOVIN 99.425 0.996176 1.00192 FBXO7 - F-box only protein 7 - Bos taurus (Bovine) - FBXO7 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity). Taurus_UMD|evm.model.AC_000162.1.669 O14994 SYN3_HUMAN 94.138 0.996546 0.998276 SYN3 - Synapsin-3 - Homo sapiens (Human) - SYN3 gene May be involved in the regulation of neurotransmitter release and synaptogenesis. Taurus_UMD|evm.model.AC_000162.1.670 Q2KIX7 HP251_BOVIN 100.000 0.99061 1.00472 Protein HP-25 homolog 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.671 Q2KIU3 HP252_BOVIN 100.000 0.990741 1.00465 Protein HP-25 homolog 2 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.672 Q2KIT0 HP20_BOVIN 100.000 0.989583 1.00524 Protein HP-20 homolog precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.673 O95461 LARG1_HUMAN 97.751 0.997358 1.00132 LARGE1 - LARGE xylosyl- and glucuronyltransferase 1 - Homo sapiens (Human) - LARGE1 gene Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:22223806). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:25279699). Taurus_UMD|evm.model.AC_000162.1.674 Q6PGH4 F222A_MOUSE 88.000 0.485149 0.222958 Fam222a - Protein FAM222A - Mus musculus (Mouse) - Fam222a gene Taurus_UMD|evm.model.AC_000162.1.675 Q2M1V0 ISX_HUMAN 68.235 0.913514 0.755102 ISX - Intestine-specific homeobox - Homo sapiens (Human) - ISX gene Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine (By similarity). Taurus_UMD|evm.model.AC_000162.1.676 Q9UGU5 HMGX4_HUMAN 93.688 0.996683 1.00333 HMGXB4 - HMG domain-containing protein 4 - Homo sapiens (Human) - HMGXB4 gene Negatively regulates Wnt/beta-catenin signaling during development. Taurus_UMD|evm.model.AC_000162.1.677 O60784 TOM1_HUMAN 92.480 0.995943 1.00203 TOM1 - Target of Myb protein 1 - Homo sapiens (Human) - TOM1 gene May be involved in intracellular trafficking. Probable association with membranes. Taurus_UMD|evm.model.AC_000162.1.678 Q5E9F2 HMOX1_BOVIN 100.000 0.993103 1.00346 HMOX1 - Heme oxygenase 1 - Bos taurus (Bovine) - HMOX1 gene Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. Taurus_UMD|evm.model.AC_000162.1.679 Q0V8B7 MCM5_BOVIN 99.864 0.997279 1.00136 MCM5 - DNA replication licensing factor MCM5 - Bos taurus (Bovine) - MCM5 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Taurus_UMD|evm.model.AC_000162.1.680 Q96D21 RHES_HUMAN 98.496 0.765896 1.30075 RASD2 - GTP-binding protein Rhes precursor - Homo sapiens (Human) - RASD2 gene GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. Taurus_UMD|evm.model.AC_000162.1.681 P02192 MYG_BOVIN 100.000 0.987097 1.00649 MB - Myoglobin - Bos taurus (Bovine) - MB gene Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. Taurus_UMD|evm.model.AC_000162.1.682 Q9BWW8 APOL6_HUMAN 55.663 0.878963 1.01166 APOL6 - Apolipoprotein L6 - Homo sapiens (Human) - APOL6 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Taurus_UMD|evm.model.AC_000162.1.683 A6QPR6 RFOX2_BOVIN 99.482 0.861298 1.13452 RBFOX2 - RNA binding protein fox-1 homolog 2 - Bos taurus (Bovine) - RBFOX2 gene RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity). Taurus_UMD|evm.model.AC_000162.1.684 P35579 MYH9_HUMAN 52.632 0.176471 0.216837 MYH9 - Myosin-9 - Homo sapiens (Human) - MYH9 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). Taurus_UMD|evm.model.AC_000162.1.685 O95236 APOL3_HUMAN 39.683 0.735714 1.04478 APOL3 - Apolipoprotein L3 - Homo sapiens (Human) - APOL3 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Taurus_UMD|evm.model.AC_000162.1.686 Q8VDD5 MYH9_MOUSE 71.053 0.158898 0.240816 Myh9 - Myosin-9 - Mus musculus (Mouse) - Myh9 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (PubMed:19401332). Required for cortical actin clearance prior to oocyte exocytosis (PubMed:31118423). Promotes cell motility in conjunction with S100A4 (By similarity). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity). Taurus_UMD|evm.model.AC_000162.1.687 P14105 MYH9_CHICK 85.366 0.258065 0.079122 MYH9 - Myosin-9 - Gallus gallus (Chicken) - MYH9 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Taurus_UMD|evm.model.AC_000162.1.689 Q9BQE5 APOL2_HUMAN 43.252 0.94362 1 APOL2 - Apolipoprotein L2 - Homo sapiens (Human) - APOL2 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Taurus_UMD|evm.model.AC_000162.1.690 P14105 MYH9_CHICK 57.317 0.457143 0.0893313 MYH9 - Myosin-9 - Gallus gallus (Chicken) - MYH9 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Taurus_UMD|evm.model.AC_000162.1.691 O95236 APOL3_HUMAN 49.275 0.557377 0.303483 APOL3 - Apolipoprotein L3 - Homo sapiens (Human) - APOL3 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Taurus_UMD|evm.model.AC_000162.1.692 O95236 APOL3_HUMAN 40.199 0.610204 1.21891 APOL3 - Apolipoprotein L3 - Homo sapiens (Human) - APOL3 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Taurus_UMD|evm.model.AC_000162.1.693 P14105 MYH9_CHICK 81.818 0.186047 0.0877999 MYH9 - Myosin-9 - Gallus gallus (Chicken) - MYH9 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Taurus_UMD|evm.model.AC_000162.1.694 Q62812 MYH9_RAT 83.721 0.0976744 0.219276 Myh9 - Myosin-9 - Rattus norvegicus (Rat) - Myh9 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (By similarity). Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (By similarity). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity). Taurus_UMD|evm.model.AC_000162.1.695 Q8VDD5 MYH9_MOUSE 85.185 0.0538302 0.246429 Myh9 - Myosin-9 - Mus musculus (Mouse) - Myh9 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (PubMed:19401332). Required for cortical actin clearance prior to oocyte exocytosis (PubMed:31118423). Promotes cell motility in conjunction with S100A4 (By similarity). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity). Taurus_UMD|evm.model.AC_000162.1.696 O95236 APOL3_HUMAN 43.713 0.959627 0.800995 APOL3 - Apolipoprotein L3 - Homo sapiens (Human) - APOL3 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Taurus_UMD|evm.model.AC_000162.1.697 O95236 APOL3_HUMAN 56.000 0.365782 0.843284 APOL3 - Apolipoprotein L3 - Homo sapiens (Human) - APOL3 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Taurus_UMD|evm.model.AC_000162.1.698 O95236 APOL3_HUMAN 45.723 0.954407 0.818408 APOL3 - Apolipoprotein L3 - Homo sapiens (Human) - APOL3 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Taurus_UMD|evm.model.AC_000162.1.699 O95236 APOL3_HUMAN 45.672 0.962733 0.800995 APOL3 - Apolipoprotein L3 - Homo sapiens (Human) - APOL3 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Taurus_UMD|evm.model.AC_000162.1.700 P14105 MYH9_CHICK 86.207 0.172727 0.168453 MYH9 - Myosin-9 - Gallus gallus (Chicken) - MYH9 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Taurus_UMD|evm.model.AC_000162.1.701 O95236 APOL3_HUMAN 52.308 0.576577 0.276119 APOL3 - Apolipoprotein L3 - Homo sapiens (Human) - APOL3 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Taurus_UMD|evm.model.AC_000162.1.702 Q9BWW8 APOL6_HUMAN 47.036 0.743363 0.988338 APOL6 - Apolipoprotein L6 - Homo sapiens (Human) - APOL6 gene May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Taurus_UMD|evm.model.AC_000162.1.703 Q258K2 MYH9_CANLF 96.633 0.996418 0.996939 MYH9 - Myosin-9 - Canis lupus familiaris (Dog) - MYH9 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (By similarity). Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (By similarity). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity). Taurus_UMD|evm.model.AC_000162.1.704 Q95108 THIOM_BOVIN 100.000 0.988024 1.00602 TXN2 - Thioredoxin, mitochondrial precursor - Bos taurus (Bovine) - TXN2 gene Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity. Taurus_UMD|evm.model.AC_000162.1.705 Q8IWF2 FXRD2_HUMAN 82.489 0.987106 1.02047 FOXRED2 - FAD-dependent oxidoreductase domain-containing protein 2 precursor - Homo sapiens (Human) - FOXRED2 gene Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. Taurus_UMD|evm.model.AC_000162.1.706 Q3T122 EIF3D_BOVIN 100.000 0.996357 1.00182 EIF3D - Eukaryotic translation initiation factor 3 subunit D - Bos taurus (Bovine) - EIF3D gene mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. Taurus_UMD|evm.model.AC_000162.1.707 Q9Y698 CCG2_HUMAN 100.000 0.993827 1.0031 CACNG2 - Voltage-dependent calcium channel gamma-2 subunit - Homo sapiens (Human) - CACNG2 gene Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Taurus_UMD|evm.model.AC_000162.1.708 Q0VCN3 IFT27_BOVIN 100.000 0.989305 1.00538 IFT27 - Intraflagellar transport protein 27 homolog - Bos taurus (Bovine) - IFT27 gene Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6. Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation. Taurus_UMD|evm.model.AC_000162.1.710 Q0VCG3 PRVA_BOVIN 100.000 0.981982 1.00909 PVALB - Parvalbumin alpha - Bos taurus (Bovine) - PVALB gene In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). Taurus_UMD|evm.model.AC_000162.1.711 Q15080 NCF4_HUMAN 89.676 0.994118 1.00295 NCF4 - Neutrophil cytosol factor 4 - Homo sapiens (Human) - NCF4 gene Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex. Taurus_UMD|evm.model.AC_000162.1.712 P32927 IL3RB_HUMAN 65.851 0.997755 0.993311 CSF2RB - Cytokine receptor common subunit beta precursor - Homo sapiens (Human) - CSF2RB gene High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. Taurus_UMD|evm.model.AC_000162.1.713 Q58DT1 RL7_BOVIN 100.000 0.990783 0.875 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Taurus_UMD|evm.model.AC_000162.1.714 P00586 THTR_BOVIN 100.000 0.47411 2.08081 TST - Thiosulfate sulfurtransferase - Bos taurus (Bovine) - TST gene Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity). Formation of iron-sulfur complexes and cyanide detoxification. Binds molecular oxygen and sulfur. Taurus_UMD|evm.model.AC_000162.1.715 P25325 THTM_HUMAN 89.226 0.888889 1.12121 MPST - 3-mercaptopyruvate sulfurtransferase - Homo sapiens (Human) - MPST gene Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions. Taurus_UMD|evm.model.AC_000162.1.716 O00370 LORF2_HUMAN 27.811 0.736239 0.341961 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000162.1.717 Q32L59 TMC5B_BOVIN 90.909 0.149826 0.817664 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Taurus_UMD|evm.model.AC_000162.1.718 Q8N5Z5 KCD17_HUMAN 89.823 0.616046 1.08723 KCTD17 - BTB/POZ domain-containing protein KCTD17 - Homo sapiens (Human) - KCTD17 gene Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598). May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243). Taurus_UMD|evm.model.AC_000162.1.719 Q8IU80 TMPS6_HUMAN 89.900 0.997503 0.98767 TMPRSS6 - Transmembrane protease serine 6 - Homo sapiens (Human) - TMPRSS6 gene Membrane-bound serine protease (PubMed:18976966, PubMed:20518742, PubMed:25156943, PubMed:25588876). Through the cleavage of cell surface HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed:25156943, PubMed:18408718, PubMed:18976966). Taurus_UMD|evm.model.AC_000162.1.720 Q38J85 IL2RB_MACFA 63.158 0.887772 1.08348 IL2RB - Interleukin-2 receptor subunit beta precursor - Macaca fascicularis (Crab-eating macaque) - IL2RB gene Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Taurus_UMD|evm.model.AC_000162.1.721 Q38J85 IL2RB_MACFA 57.746 0.55643 0.69147 IL2RB - Interleukin-2 receptor subunit beta precursor - Macaca fascicularis (Crab-eating macaque) - IL2RB gene Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Taurus_UMD|evm.model.AC_000162.1.722 Q3T1I2 C1QT6_RAT 73.507 0.988889 1.02662 C1qtnf6 - Complement C1q tumor necrosis factor-related protein 6 precursor - Rattus norvegicus (Rat) - C1qtnf6 gene extracellular space, protein-containing complex, identical protein binding Taurus_UMD|evm.model.AC_000162.1.723 P61294 RAB6B_MOUSE 73.770 0.869565 0.331731 Rab6b - Ras-related protein Rab-6B - Mus musculus (Mouse) - Rab6b gene Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (By similarity). Taurus_UMD|evm.model.AC_000162.1.724 P32745 SSR3_HUMAN 86.730 0.995272 1.01196 SSTR3 - Somatostatin receptor type 3 - Homo sapiens (Human) - SSTR3 gene Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. Taurus_UMD|evm.model.AC_000162.1.725 Q9TU25 RAC2_BOVIN 100.000 0.989637 1.00521 RAC2 - Ras-related C3 botulinum toxin substrate 2 precursor - Bos taurus (Bovine) - RAC2 gene Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity). Taurus_UMD|evm.model.AC_000162.1.726 Q9UIA0 CYH4_HUMAN 94.133 0.951338 1.04315 CYTH4 - Cytohesin-4 - Homo sapiens (Human) - CYTH4 gene Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP. Taurus_UMD|evm.model.AC_000162.1.727 Q5R3F8 PPR29_HUMAN 94.539 0.997576 1.0061 ELFN2 - Protein phosphatase 1 regulatory subunit 29 precursor - Homo sapiens (Human) - ELFN2 gene Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. Taurus_UMD|evm.model.AC_000162.1.728 O00587 MFNG_HUMAN 87.812 0.993769 1 MFNG - Beta-1,3-N-acetylglucosaminyltransferase manic fringe - Homo sapiens (Human) - MFNG gene Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Taurus_UMD|evm.model.AC_000162.1.729 Q9BWT7 CAR10_HUMAN 92.163 0.972763 0.996124 CARD10 - Caspase recruitment domain-containing protein 10 - Homo sapiens (Human) - CARD10 gene Activates NF-kappa-B via BCL10 and IKK. Taurus_UMD|evm.model.AC_000162.1.730 Q3LFD5 UBP41_HUMAN 76.471 0.947205 0.899441 USP41 - Putative ubiquitin carboxyl-terminal hydrolase 41 - Homo sapiens (Human) - USP41 gene May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Taurus_UMD|evm.model.AC_000162.1.731 Q5BKT4 AG10A_HUMAN 92.616 0.874307 1.14376 ALG10 - Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase - Homo sapiens (Human) - ALG10 gene Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. Taurus_UMD|evm.model.AC_000162.1.732 Q5RCK6 SYT10_PONAB 86.538 0.708333 0.137667 SYT10 - Synaptotagmin-10 - Pongo abelii (Sumatran orangutan) - SYT10 gene Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Taurus_UMD|evm.model.AC_000162.1.733 Q5RCK6 SYT10_PONAB 93.956 0.93299 0.370937 SYT10 - Synaptotagmin-10 - Pongo abelii (Sumatran orangutan) - SYT10 gene Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Taurus_UMD|evm.model.AC_000162.1.735 Q99959 PKP2_HUMAN 82.105 0.541069 0.870602 PKP2 - Plakophilin-2 - Homo sapiens (Human) - PKP2 gene May play a role in junctional plaques. Taurus_UMD|evm.model.AC_000162.1.736 Q9Y2Z4 SYYM_HUMAN 89.121 0.995825 1.00419 YARS2 - Tyrosine--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - YARS2 gene Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Taurus_UMD|evm.model.AC_000162.1.737 O00429 DNM1L_HUMAN 99.321 0.948387 1.05299 DNM1L - Dynamin-1-like protein - Homo sapiens (Human) - DNM1L gene Functions in mitochondrial and peroxisomal division (PubMed:9570752, PubMed:9786947, PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17553808, PubMed:17460227, PubMed:18695047, PubMed:18838687, PubMed:19638400, PubMed:19411255, PubMed:19342591, PubMed:23921378, PubMed:23283981, PubMed:23530241, PubMed:29478834, PubMed:32484300, PubMed:27145208, PubMed:26992161, PubMed:27301544, PubMed:27328748). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23921378, PubMed:23283981, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:27145208, PubMed:26992161, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:9570752, PubMed:20688057, PubMed:23792689). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). Taurus_UMD|evm.model.AC_000162.1.738 Q96M96 FGD4_HUMAN 90.811 0.808324 1.19191 FGD4 - FYVE, RhoGEF and PH domain-containing protein 4 - Homo sapiens (Human) - FGD4 gene Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). Taurus_UMD|evm.model.AC_000162.1.739 Q96G01 BICD1_HUMAN 98.250 0.979381 0.895385 BICD1 - Protein bicaudal D homolog 1 - Homo sapiens (Human) - BICD1 gene Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. Taurus_UMD|evm.model.AC_000162.1.740 Q9HCM1 RESF1_HUMAN 61.439 0.998852 0.997138 RESF1 - Retroelement silencing factor 1 - Homo sapiens (Human) - RESF1 gene Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. Taurus_UMD|evm.model.AC_000162.1.742 Q32L08 AMN1_BOVIN 99.612 0.992278 1.00388 AMN1 - Protein AMN1 homolog - Bos taurus (Bovine) - AMN1 gene Taurus_UMD|evm.model.AC_000162.1.743 Q8IXQ9 ETKMT_HUMAN 81.203 0.992453 1.01145 ETFBKMT - Electron transfer flavoprotein beta subunit lysine methyltransferase precursor - Homo sapiens (Human) - ETFBKMT gene Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria (PubMed:25023281, PubMed:25416781). Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain (PubMed:25416781). Taurus_UMD|evm.model.AC_000162.1.744 Q6ZUT9 DEN5B_HUMAN 97.174 0.998431 1.00078 DENND5B - DENN domain-containing protein 5B - Homo sapiens (Human) - DENND5B gene Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Taurus_UMD|evm.model.AC_000162.1.745 Q9NP50 SHCAF_HUMAN 100.000 0.990991 1.00452 SINHCAF - SIN3-HDAC complex-associated factor - Homo sapiens (Human) - SINHCAF gene Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity). Taurus_UMD|evm.model.AC_000162.1.746 Q6IMN6 CAPR2_HUMAN 92.157 0.989805 0.957409 CAPRIN2 - Caprin-2 - Homo sapiens (Human) - CAPRIN2 gene Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112). Taurus_UMD|evm.model.AC_000162.1.747 O15397 IPO8_HUMAN 97.011 0.998073 1.00096 IPO8 - Importin-8 - Homo sapiens (Human) - IPO8 gene Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. Taurus_UMD|evm.model.AC_000162.1.751 Q8IUR5 TMTC1_HUMAN 87.619 0.780303 0.44898 TMTC1 - Protein O-mannosyl-transferase TMTC1 - Homo sapiens (Human) - TMTC1 gene Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Taurus_UMD|evm.model.AC_000162.1.752 Q8IUR5 TMTC1_HUMAN 77.407 0.572727 0.498866 TMTC1 - Protein O-mannosyl-transferase TMTC1 - Homo sapiens (Human) - TMTC1 gene Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Taurus_UMD|evm.model.AC_000162.1.753 Q7RTY7 OVCH1_HUMAN 69.718 0.215046 1.16049 OVCH1 - Ovochymase-1 precursor - Homo sapiens (Human) - OVCH1 gene Taurus_UMD|evm.model.AC_000162.1.754 Q4R5C3 ERGI2_MACFA 95.225 0.994709 1.00265 ERGIC2 - Endoplasmic reticulum-Golgi intermediate compartment protein 2 - Macaca fascicularis (Crab-eating macaque) - ERGIC2 gene Possible role in transport between endoplasmic reticulum and Golgi. Taurus_UMD|evm.model.AC_000162.1.755 Q0P5J1 FACR2_BOVIN 100.000 0.996124 1.00194 FAR2 - Fatty acyl-CoA reductase 2 - Bos taurus (Bovine) - FAR2 gene Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates. Taurus_UMD|evm.model.AC_000162.1.756 P62912 RL32_RAT 83.019 0.597701 0.644444 Rpl32 - 60S ribosomal protein L32 - Rattus norvegicus (Rat) - Rpl32 gene cytosolic large ribosomal subunit, polysomal ribosome, cellular response to dexamethasone stimulus, cytoplasmic translation, liver regeneration Taurus_UMD|evm.model.AC_000162.1.757 Q7Z6B0 CCD91_HUMAN 92.986 0.995485 1.00454 CCDC91 - Coiled-coil domain-containing protein 91 - Homo sapiens (Human) - CCDC91 gene Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. Taurus_UMD|evm.model.AC_000162.1.759 P58073 PTHR_BOVIN 100.000 0.674419 1.45763 PTHLH - Parathyroid hormone-related protein precursor - Bos taurus (Bovine) - PTHLH gene Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Taurus_UMD|evm.model.AC_000162.1.760 P13184 CX7A2_BOVIN 93.976 0.97619 1.01205 COX7A2 - Cytochrome c oxidase subunit 7A2, mitochondrial precursor - Bos taurus (Bovine) - COX7A2 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000162.1.761 Q9P2K6 KLH42_HUMAN 95.455 0.996055 1.00396 KLHL42 - Kelch-like protein 42 - Homo sapiens (Human) - KLHL42 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis. Taurus_UMD|evm.model.AC_000162.1.762 A6NHS7 MANS4_HUMAN 80.723 0.988024 0.982353 MANSC4 - MANSC domain-containing protein 4 precursor - Homo sapiens (Human) - MANSC4 gene Taurus_UMD|evm.model.AC_000162.1.763 Q2YDF6 RT35_BOVIN 100.000 0.993865 1.00308 MRPS35 - 28S ribosomal protein S35, mitochondrial precursor - Bos taurus (Bovine) - MRPS35 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000162.1.764 Q6BDI9 REP15_HUMAN 79.661 0.991416 0.987288 REP15 - Rab15 effector protein - Homo sapiens (Human) - REP15 gene Regulates transferrin receptor recycling from the endocytic recycling compartment. Taurus_UMD|evm.model.AC_000162.1.765 Q8C8U0 LIPB1_MOUSE 86.866 0.998006 1.03509 Ppfibp1 - Liprin-beta-1 - Mus musculus (Mouse) - Ppfibp1 gene May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity). Taurus_UMD|evm.model.AC_000162.1.766 Q32LI3 CL071_BOVIN 100.000 0.793939 0.951009 Uncharacterized protein C12orf71 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.767 P62828 RAN_RAT 83.796 0.989071 0.847222 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Taurus_UMD|evm.model.AC_000162.1.769 A6NFE2 SMCO2_HUMAN 55.000 0.99373 0.930029 SMCO2 - Single-pass membrane and coiled-coil domain-containing protein 2 - Homo sapiens (Human) - SMCO2 gene Taurus_UMD|evm.model.AC_000162.1.770 Q8WYA1 BMAL2_HUMAN 83.387 0.806202 1.21698 ARNTL2 - Aryl hydrocarbon receptor nuclear translocator-like protein 2 - Homo sapiens (Human) - ARNTL2 gene Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. Taurus_UMD|evm.model.AC_000162.1.772 Q9Y2H1 ST38L_HUMAN 99.138 0.995699 1.00216 STK38L - Serine/threonine-protein kinase 38-like - Homo sapiens (Human) - STK38L gene Involved in the regulation of structural processes in differentiating and mature neuronal cells. Taurus_UMD|evm.model.AC_000162.1.773 Q2TBU8 MED21_BOVIN 100.000 0.986207 1.00694 MED21 - Mediator of RNA polymerase II transcription subunit 21 - Bos taurus (Bovine) - MED21 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Taurus_UMD|evm.model.AC_000162.1.774 Q9NS93 TM7S3_HUMAN 82.807 0.996497 1.00175 TM7SF3 - Transmembrane 7 superfamily member 3 precursor - Homo sapiens (Human) - TM7SF3 gene Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623). Taurus_UMD|evm.model.AC_000162.1.775 Q9NVK5 FGOP2_HUMAN 97.628 0.980545 1.01581 FGFR1OP2 - FGFR1 oncogene partner 2 - Homo sapiens (Human) - FGFR1OP2 gene May be involved in wound healing pathway. Taurus_UMD|evm.model.AC_000162.1.776 Q9NVM9 INT13_HUMAN 99.150 0.997171 1.00142 INTS13 - Integrator complex subunit 13 - Homo sapiens (Human) - INTS13 gene Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (PubMed:23904267). Taurus_UMD|evm.model.AC_000162.1.777 P62752 RL23A_RAT 68.254 0.77305 0.903846 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000162.1.778 Q8WN96 ITPR2_BOVIN 97.383 0.998197 0.410589 ITPR2 - Inositol 1,4,5-trisphosphate receptor type 2 - Bos taurus (Bovine) - ITPR2 gene Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium (PubMed:11584008). This release is regulated by cAMP both dependently and independently of PKA (By similarity). Taurus_UMD|evm.model.AC_000162.1.779 Q14714 SSPN_HUMAN 87.654 0.99177 1 SSPN - Sarcospan - Homo sapiens (Human) - SSPN gene Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC. Taurus_UMD|evm.model.AC_000162.1.780 Q9C0J9 BHE41_HUMAN 94.810 0.782609 0.763485 BHLHE41 - Class E basic helix-loop-helix protein 41 - Homo sapiens (Human) - BHLHE41 gene Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:11278948, PubMed:14672706, PubMed:15193144, PubMed:15560782, PubMed:18411297, PubMed:19786558, PubMed:25083013). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:25083013). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11 (By similarity). Taurus_UMD|evm.model.AC_000162.1.781 Q8NHQ8 RASF8_HUMAN 98.091 0.995238 1.00239 RASSF8 - Ras association domain-containing protein 8 - Homo sapiens (Human) - RASSF8 gene Taurus_UMD|evm.model.AC_000162.1.782 Q96MW7 TIGD1_HUMAN 45.012 0.993506 0.521151 TIGD1 - Tigger transposable element-derived protein 1 - Homo sapiens (Human) - TIGD1 gene nucleus, DNA binding Taurus_UMD|evm.model.AC_000162.1.783 Q4R899 LMTD1_MACFA 54.177 0.904762 0.935644 LMNTD1 - Lamin tail domain-containing protein 1 - Macaca fascicularis (Crab-eating macaque) - LMNTD1 gene Taurus_UMD|evm.model.AC_000162.1.784 P79800 RASK_MELGA 99.468 0.989418 1.00532 KRAS - GTPase KRas precursor - Meleagris gallopavo (Wild turkey) - KRAS gene Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. May play a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs). Taurus_UMD|evm.model.AC_000162.1.785 Q0VCR0 ETFR1_BOVIN 100.000 0.977528 1.01136 ETFRF1 - Electron transfer flavoprotein regulatory factor 1 - Bos taurus (Bovine) - ETFRF1 gene Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). Taurus_UMD|evm.model.AC_000162.1.786 Q29RU8 CASC1_BOVIN 100.000 0.572438 0.791608 DNAI7 - Dynein axonemal intermediate chain 7 - Bos taurus (Bovine) - DNAI7 gene Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function. May act as a cell cycle regulator. Taurus_UMD|evm.model.AC_000162.1.787 Q12912 IRAG2_HUMAN 80.541 0.382108 2.5982 IRAG2 - Inositol 1,4,5-triphosphate receptor associated 2 - Homo sapiens (Human) - IRAG2 gene Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Taurus_UMD|evm.model.AC_000162.1.789 Q9GKM4 BCAT1_SHEEP 98.177 0.9599 1.03636 BCAT1 - Branched-chain-amino-acid aminotransferase, cytosolic - Ovis aries (Sheep) - BCAT1 gene Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Taurus_UMD|evm.model.AC_000162.1.790 P35711 SOX5_HUMAN 94.889 0.997257 0.955439 SOX5 - Transcription factor SOX-5 - Homo sapiens (Human) - SOX5 gene Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene. Taurus_UMD|evm.model.AC_000162.1.791 Q2KI06 PHOP2_BOVIN 100.000 0.983051 0.244813 PHOSPHO2 - Pyridoxal phosphate phosphatase PHOSPHO2 - Bos taurus (Bovine) - PHOSPHO2 gene Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate (By similarity). Taurus_UMD|evm.model.AC_000162.1.793 P47914 RL29_HUMAN 67.925 0.452174 0.72327 RPL29 - 60S ribosomal protein L29 - Homo sapiens (Human) - RPL29 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000162.1.794 Q9HBU6 EKI1_HUMAN 97.521 0.994505 0.80531 ETNK1 - Ethanolamine kinase 1 - Homo sapiens (Human) - ETNK1 gene Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis. Taurus_UMD|evm.model.AC_000162.1.795 Q86YS7 C2CD5_HUMAN 93.245 0.998099 1.052 C2CD5 - C2 domain-containing protein 5 - Homo sapiens (Human) - C2CD5 gene Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. Taurus_UMD|evm.model.AC_000162.1.796 Q6ZXD2 SIA8A_BOVIN 99.719 0.994398 1.00281 ST8SIA1 - Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase - Bos taurus (Bovine) - ST8SIA1 gene Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid (By similarity). Can catalyze the addition of a second alpha-2,8- sialic acid to GD3 to form GT3 (By similarity). Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively (By similarity). Taurus_UMD|evm.model.AC_000162.1.797 Q9QWG7 ST1B1_MOUSE 38.783 0.863636 0.956522 Sult1b1 - Sulfotransferase family cytosolic 1B member 1 - Mus musculus (Mouse) - Sult1b1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates L-DOPA and D-DOPA, tyrosine isomers such as DL-m-tyrosine, dopamine and thyroid hormones. Taurus_UMD|evm.model.AC_000162.1.798 Q3SZM5 NEUA_BOVIN 93.349 0.995305 0.981567 CMAS - N-acylneuraminate cytidylyltransferase - Bos taurus (Bovine) - CMAS gene Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (By similarity). Taurus_UMD|evm.model.AC_000162.1.799 O60706 ABCC9_HUMAN 96.893 0.996129 1.00065 ABCC9 - ATP-binding cassette sub-family C member 9 - Homo sapiens (Human) - ABCC9 gene Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Taurus_UMD|evm.model.AC_000162.1.800 Q15842 KCNJ8_HUMAN 99.764 0.995294 1.00236 KCNJ8 - ATP-sensitive inward rectifier potassium channel 8 - Homo sapiens (Human) - KCNJ8 gene This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity). Taurus_UMD|evm.model.AC_000162.1.801 Q5E9B1 LDHB_BOVIN 100.000 0.99403 1.00299 LDHB - L-lactate dehydrogenase B chain - Bos taurus (Bovine) - LDHB gene L-lactate dehydrogenase activity Taurus_UMD|evm.model.AC_000162.1.802 P54840 GYS2_HUMAN 93.457 0.997155 1 GYS2 - Glycogen [starch] synthase, liver - Homo sapiens (Human) - GYS2 gene Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Taurus_UMD|evm.model.AC_000162.1.803 Q0VC44 SPXN_BOVIN 100.000 0.982906 1.00862 SPX - Spexin precursor - Bos taurus (Bovine) - SPX gene Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity). Taurus_UMD|evm.model.AC_000162.1.804 Q9Y3E0 GOT1B_HUMAN 96.296 0.985294 0.985507 GOLT1B - Vesicle transport protein GOT1B - Homo sapiens (Human) - GOLT1B gene May be involved in fusion of ER-derived transport vesicles with the Golgi complex. Taurus_UMD|evm.model.AC_000162.1.805 P46063 RECQ1_HUMAN 90.447 0.829706 1.20339 RECQL - ATP-dependent DNA helicase Q1 - Homo sapiens (Human) - RECQL gene DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Taurus_UMD|evm.model.AC_000162.1.806 A7YVH9 PYRD1_BOVIN 100.000 0.996024 1.00199 PYROXD1 - Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 - Bos taurus (Bovine) - PYROXD1 gene Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (By similarity). Required for normal sarcomere structure and muscle fiber integrity (By similarity). Taurus_UMD|evm.model.AC_000162.1.808 P46721 SO1A2_HUMAN 82.090 0.997001 0.995522 SLCO1A2 - Solute carrier organic anion transporter family member 1A2 - Homo sapiens (Human) - SLCO1A2 gene Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin. Taurus_UMD|evm.model.AC_000162.1.809 Q9NPD5 SO1B3_HUMAN 71.131 0.972464 0.982906 SLCO1B3 - Solute carrier organic anion transporter family member 1B3 - Homo sapiens (Human) - SLCO1B3 gene Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver. Taurus_UMD|evm.model.AC_000162.1.810 Q9GMU6 SO1C1_MACFA 87.413 0.638806 1.11296 SLCO1C1 - Solute carrier organic anion transporter family member 1C1 - Macaca fascicularis (Crab-eating macaque) - SLCO1C1 gene Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), estradiol-17-beta-glucuronide, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a significant role in regulating T4 flux into and out of the brain (By similarity). Taurus_UMD|evm.model.AC_000162.1.811 Q14432 PDE3A_HUMAN 87.029 0.998165 0.955302 PDE3A - cGMP-inhibited 3',5'-cyclic phosphodiesterase A - Homo sapiens (Human) - PDE3A gene Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Taurus_UMD|evm.model.AC_000162.1.812 A4FV57 AEBP2_BOVIN 100.000 0.996094 1.00196 AEBP2 - Zinc finger protein AEBP2 - Bos taurus (Bovine) - AEBP2 gene Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene. Plays a role in nucleosome localization of the PRC2 complex. Taurus_UMD|evm.model.AC_000162.1.813 Q9HAU0 PKHA5_HUMAN 67.954 0.917431 1.17204 PLEKHA5 - Pleckstrin homology domain-containing family A member 5 - Homo sapiens (Human) - PLEKHA5 gene cytosol, membrane, nucleoplasm, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylinositol-5-phosphate binding Taurus_UMD|evm.model.AC_000162.1.814 Q4R7M8 CAZA3_MACFA 91.930 0.946667 1.00334 CAPZA3 - F-actin-capping protein subunit alpha-3 - Macaca fascicularis (Crab-eating macaque) - CAPZA3 gene F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity). Taurus_UMD|evm.model.AC_000162.1.815 Q1RML2 PLCZ1_BOVIN 100.000 0.99681 0.988959 PLCZ1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 - Bos taurus (Bovine) - PLCZ1 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. Taurus_UMD|evm.model.AC_000162.1.816 O75747 P3C2G_HUMAN 79.772 0.998635 1.01384 PIK3C2G - Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma - Homo sapiens (Human) - PIK3C2G gene Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity). Taurus_UMD|evm.model.AC_000162.1.817 A6QP66 RERGL_BOVIN 100.000 0.990244 1.0049 RERGL - Ras-related and estrogen-regulated growth inhibitor-like protein - Bos taurus (Bovine) - RERGL gene Binds GDP/GTP and may possess intrinsic GTPase activity. Taurus_UMD|evm.model.AC_000162.1.818 P18621 RL17_HUMAN 80.000 0.985714 0.380435 RPL17 - 60S ribosomal protein L17 - Homo sapiens (Human) - RPL17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000162.1.820 Q5RBW7 LMO3_PONAB 100.000 0.986301 1.0069 LMO3 - LIM domain only protein 3 - Pongo abelii (Sumatran orangutan) - LMO3 gene Taurus_UMD|evm.model.AC_000162.1.821 Q0VCQ1 CTBP2_BOVIN 83.186 0.982456 0.25618 CTBP2 - C-terminal-binding protein 2 - Bos taurus (Bovine) - CTBP2 gene Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). Isoform 2 probably acts as a scaffold for specialized synapses. Taurus_UMD|evm.model.AC_000162.1.822 Q9EQH5 CTBP2_RAT 91.935 0.516949 0.265169 Ctbp2 - C-terminal-binding protein 2 - Rattus norvegicus (Rat) - Ctbp2 gene Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Isoform 2 probably acts as a scaffold for specialized synapses (By similarity). Taurus_UMD|evm.model.AC_000162.1.823 Q64L89 MGST1_BOVIN 98.065 0.987179 1.00645 MGST1 - Microsomal glutathione S-transferase 1 - Bos taurus (Bovine) - MGST1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity (By similarity). Taurus_UMD|evm.model.AC_000162.1.824 Q3T0V9 DEOC_BOVIN 100.000 0.99373 1.00314 DERA - Deoxyribose-phosphate aldolase - Bos taurus (Bovine) - DERA gene Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation. Taurus_UMD|evm.model.AC_000162.1.825 Q5E959 STRAP_BOVIN 100.000 0.994302 1.00286 STRAP - Serine-threonine kinase receptor-associated protein - Bos taurus (Bovine) - STRAP gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity). Taurus_UMD|evm.model.AC_000162.1.826 Q12929 EPS8_HUMAN 90.488 0.993902 0.997567 EPS8 - Epidermal growth factor receptor kinase substrate 8 - Homo sapiens (Human) - EPS8 gene Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. Taurus_UMD|evm.model.AC_000162.1.827 Q16827 PTPRO_HUMAN 93.174 0.998318 0.977796 PTPRO - Receptor-type tyrosine-protein phosphatase O precursor - Homo sapiens (Human) - PTPRO gene Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity). Taurus_UMD|evm.model.AC_000162.1.829 Q0VCJ7 RERG_BOVIN 100.000 0.99 1.00503 RERG - Ras-related and estrogen-regulated growth inhibitor - Bos taurus (Bovine) - RERG gene Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP (By similarity). Taurus_UMD|evm.model.AC_000162.1.830 P22571 CNCG_BOVIN 100.000 0.97619 1.01205 PDE6H - Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma - Bos taurus (Bovine) - PDE6H gene Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. Taurus_UMD|evm.model.AC_000162.1.831 Q9TU03 GDIR2_BOVIN 100.000 0.728938 1.365 ARHGDIB - Rho GDP-dissociation inhibitor 2 - Bos taurus (Bovine) - ARHGDIB gene Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members. Taurus_UMD|evm.model.AC_000162.1.832 Q32L47 ERP27_BOVIN 100.000 0.897351 1.11029 ERP27 - Endoplasmic reticulum resident protein 27 precursor - Bos taurus (Bovine) - ERP27 gene Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates. Binds protein substrates via a hydrophobic pocket in the C-terminal domain. May play a role in the unfolded stress response. Taurus_UMD|evm.model.AC_000162.1.833 P07507 MGP_BOVIN 100.000 0.980769 1.00971 MGP - Matrix Gla protein precursor - Bos taurus (Bovine) - MGP gene Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. Taurus_UMD|evm.model.AC_000162.1.834 Q95NE0 NAR4_PANTR 65.806 0.938272 1.03185 ART4 - Ecto-ADP-ribosyltransferase 4 precursor - Pan troglodytes (Chimpanzee) - ART4 gene NAD+ ADP-ribosyltransferase activity, peptidyl-arginine ADP-ribosylation Taurus_UMD|evm.model.AC_000162.1.835 Q5U649 CL060_HUMAN 66.803 0.991632 0.97551 C12orf60 - Uncharacterized protein C12orf60 - Homo sapiens (Human) - C12orf60 gene Taurus_UMD|evm.model.AC_000162.1.836 A2RU48 SMCO3_HUMAN 91.556 0.99115 1.00444 SMCO3 - Single-pass membrane and coiled-coil domain-containing protein 3 - Homo sapiens (Human) - SMCO3 gene Taurus_UMD|evm.model.AC_000162.1.837 Q9Y2W2 WBP11_HUMAN 97.352 0.99688 1 WBP11 - WW domain-binding protein 11 - Homo sapiens (Human) - WBP11 gene Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. Taurus_UMD|evm.model.AC_000162.1.838 Q9BTM1 H2AJ_HUMAN 100.000 0.984615 1.00775 H2AJ - Histone H2A.J - Homo sapiens (Human) - H2AJ gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000162.1.839 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000162.1.840 P55204 GUC2C_PIG 92.824 0.998136 1 GUCY2C - Heat-stable enterotoxin receptor precursor - Sus scrofa (Pig) - GUCY2C gene Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin (By similarity). Taurus_UMD|evm.model.AC_000162.1.841 Q9GL30 PLBL1_BOVIN 100.000 0.996337 1.00183 PLBD1 - Phospholipase B-like 1 precursor - Bos taurus (Bovine) - PLBD1 gene Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids (By similarity). However, in view of the small size of the putative binding pocket, it has been proposed that it may act rather as an amidase or a peptidase (PubMed:23934913). Taurus_UMD|evm.model.AC_000162.1.842 Q6VMQ6 MCAF1_HUMAN 80.534 0.998319 0.937008 ATF7IP - Activating transcription factor 7-interacting protein 1 - Homo sapiens (Human) - ATF7IP gene Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). Taurus_UMD|evm.model.AC_000162.1.845 Q5R1P3 NMDE2_CANLF 99.410 0.862245 0.263973 GRIN2B - Glutamate receptor ionotropic, NMDA 2B precursor - Canis lupus familiaris (Dog) - GRIN2B gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (By similarity). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity). Taurus_UMD|evm.model.AC_000162.1.846 Q01097 NMDE2_MOUSE 100.000 0.159292 0.686235 Grin2b - Glutamate receptor ionotropic, NMDA 2B precursor - Mus musculus (Mouse) - Grin2b gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1377365, PubMed:26912815). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:1377365). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (PubMed:20141836). Contributes to neural pattern formation in the developing brain (PubMed:8789948). Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (PubMed:8789948). Taurus_UMD|evm.model.AC_000162.1.847 P54850 EMP1_RABIT 81.875 0.987578 1.00625 EMP1 - Epithelial membrane protein 1 - Oryctolagus cuniculus (Rabbit) - EMP1 gene Taurus_UMD|evm.model.AC_000162.1.848 Q3SZT1 GSG1_BOVIN 88.462 0.952756 1.17957 GSG1 - Germ cell-specific gene 1 protein - Bos taurus (Bovine) - GSG1 gene May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum. Taurus_UMD|evm.model.AC_000162.1.849 A2RU67 F234B_HUMAN 88.604 0.996795 1.00322 FAM234B - Protein FAM234B - Homo sapiens (Human) - FAM234B gene Taurus_UMD|evm.model.AC_000162.1.850 Q148C9 HEBP1_BOVIN 100.000 0.989583 1.00524 HEBP1 - Heme-binding protein 1 - Bos taurus (Bovine) - HEBP1 gene May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity). Taurus_UMD|evm.model.AC_000162.1.851 Q9NZD1 GPC5D_HUMAN 85.804 0.895184 1.02319 GPRC5D - G-protein coupled receptor family C group 5 member D - Homo sapiens (Human) - GPRC5D gene extracellular exosome, intracellular membrane-bounded organelle, plasma membrane, receptor complex, protein kinase activator activity Taurus_UMD|evm.model.AC_000162.1.852 Q8NFJ5 RAI3_HUMAN 77.812 0.836735 1.09804 GPRC5A - Retinoic acid-induced protein 3 - Homo sapiens (Human) - GPRC5A gene Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). Taurus_UMD|evm.model.AC_000162.1.853 Q29S22 DDX47_BOVIN 100.000 0.995633 1.00219 DDX47 - Probable ATP-dependent RNA helicase DDX47 - Bos taurus (Bovine) - DDX47 gene Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors (By similarity). Taurus_UMD|evm.model.AC_000162.1.854 Q96LR9 APLD1_HUMAN 90.650 0.991903 0.885305 APOLD1 - Apolipoprotein L domain-containing protein 1 - Homo sapiens (Human) - APOLD1 gene May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability. Taurus_UMD|evm.model.AC_000162.1.855 O19001 CDN1B_FELCA 93.939 0.98995 1.00505 CDKN1B - Cyclin-dependent kinase inhibitor 1B - Felis catus (Cat) - CDKN1B gene Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. Taurus_UMD|evm.model.AC_000162.1.856 Q15760 GPR19_HUMAN 91.084 0.990431 1.00723 GPR19 - Probable G-protein coupled receptor 19 - Homo sapiens (Human) - GPR19 gene Orphan receptor. Taurus_UMD|evm.model.AC_000162.1.857 Q0VD32 CRBL2_BOVIN 100.000 0.887218 1.10833 CREBL2 - cAMP-responsive element-binding protein-like 2 - Bos taurus (Bovine) - CREBL2 gene Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Taurus_UMD|evm.model.AC_000162.1.858 Q9BY84 DUS16_HUMAN 100.000 0.138122 0.816541 DUSP16 - Dual specificity protein phosphatase 16 - Homo sapiens (Human) - DUSP16 gene Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. Taurus_UMD|evm.model.AC_000162.1.859 Q08DP2 BORC5_BOVIN 100.000 0.703971 1.41327 BORCS5 - BLOC-1-related complex subunit 5 - Bos taurus (Bovine) - BORCS5 gene As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility. Taurus_UMD|evm.model.AC_000162.1.861 Q9H8J5 MANS1_HUMAN 59.217 0.995169 0.960557 MANSC1 - MANSC domain-containing protein 1 precursor - Homo sapiens (Human) - MANSC1 gene Taurus_UMD|evm.model.AC_000162.1.862 O75581 LRP6_HUMAN 98.512 0.998761 1.00062 LRP6 - Low-density lipoprotein receptor-related protein 6 precursor - Homo sapiens (Human) - LRP6 gene Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). Taurus_UMD|evm.model.AC_000162.1.863 Q5E9L4 B2L14_BOVIN 90.028 0.994475 1.11043 BCL2L14 - Apoptosis facilitator Bcl-2-like protein 14 - Bos taurus (Bovine) - BCL2L14 gene Plays a role in apoptosis. Taurus_UMD|evm.model.AC_000162.1.864 Q0VC65 ETV6_BOVIN 98.441 0.976035 1.01549 ETV6 - Transcription factor ETV6 - Bos taurus (Bovine) - ETV6 gene Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. Taurus_UMD|evm.model.AC_000162.1.865 P99027 RLA2_MOUSE 78.182 0.771429 0.608696 Rplp2 - 60S acidic ribosomal protein P2 - Mus musculus (Mouse) - Rplp2 gene Plays an important role in the elongation step of protein synthesis. Taurus_UMD|evm.model.AC_000162.1.866 P27393 CO4A2_ASCSU 23.166 0.708824 0.192853 Collagen alpha-2(IV) chain precursor - Ascaris suum (Pig roundworm) Taurus_UMD|evm.model.AC_000162.1.871 P0DMW3 SIML1_HUMAN 92.857 0.797101 1.01471 SMIM10L1 - Small integral membrane protein 10-like protein 1 - Homo sapiens (Human) - SMIM10L1 gene Taurus_UMD|evm.model.AC_000162.1.872 Q646A0 T2R20_GORGO 62.000 0.919753 0.524272 TAS2R20 - Taste receptor type 2 member 20 - Gorilla gorilla gorilla (Western lowland gorilla) - TAS2R20 gene Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Taurus_UMD|evm.model.AC_000162.1.875 P67809 YBOX1_HUMAN 94.505 0.200893 1.38272 YBX1 - Y-box-binding protein 1 - Homo sapiens (Human) - YBX1 gene DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:8188694, PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:8188694, PubMed:18809583). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). Taurus_UMD|evm.model.AC_000162.1.876 Q6J9G0 STYK1_HUMAN 76.540 0.983645 1.01422 STYK1 - Tyrosine-protein kinase STYK1 - Homo sapiens (Human) - STYK1 gene Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). Taurus_UMD|evm.model.AC_000162.1.877 Q0VC92 MGN2_BOVIN 100.000 0.986577 1.00676 MAGOHB - Protein mago nashi homolog 2 - Bos taurus (Bovine) - MAGOHB gene Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway. Taurus_UMD|evm.model.AC_000162.1.878 Q60660 KLRA2_MOUSE 42.909 0.925424 1.02431 Klra2 - Killer cell lectin-like receptor 2 - Mus musculus (Mouse) - Klra2 gene Receptor on natural killer (NK) cells for class I MHC. Taurus_UMD|evm.model.AC_000162.1.879 Q95MI5 NKG2A_PANTR 60.526 0.974138 0.497854 KLRC1 - NKG2-A/NKG2-B type II integral membrane protein - Pan troglodytes (Chimpanzee) - KLRC1 gene Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule MHC-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Upon MHC-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions. Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity. On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens. In MHC-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion. Taurus_UMD|evm.model.AC_000162.1.880 Q07444 NKG2E_HUMAN 47.742 0.772727 0.825 KLRC3 - NKG2-E type II integral membrane protein - Homo sapiens (Human) - KLRC3 gene Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Taurus_UMD|evm.model.AC_000162.1.881 P26715 NKG2A_HUMAN 59.140 0.807018 0.48927 KLRC1 - NKG2-A/NKG2-B type II integral membrane protein - Homo sapiens (Human) - KLRC1 gene Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self (PubMed:9486650, PubMed:18083576, PubMed:9430220). Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules (PubMed:9485206, PubMed:12165520). Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions (PubMed:9486650, PubMed:9430220, PubMed:9485206, PubMed:30860984). Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity (PubMed:12387742). On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens (PubMed:18064301). In HLA-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion (PubMed:30503213, PubMed:30860984). Taurus_UMD|evm.model.AC_000162.1.882 P26715 NKG2A_HUMAN 48.291 0.983051 1.01288 KLRC1 - NKG2-A/NKG2-B type II integral membrane protein - Homo sapiens (Human) - KLRC1 gene Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self (PubMed:9486650, PubMed:18083576, PubMed:9430220). Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules (PubMed:9485206, PubMed:12165520). Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions (PubMed:9486650, PubMed:9430220, PubMed:9485206, PubMed:30860984). Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity (PubMed:12387742). On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens (PubMed:18064301). In HLA-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion (PubMed:30503213, PubMed:30860984). Taurus_UMD|evm.model.AC_000162.1.883 P26715 NKG2A_HUMAN 35.602 0.835681 0.914163 KLRC1 - NKG2-A/NKG2-B type II integral membrane protein - Homo sapiens (Human) - KLRC1 gene Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self (PubMed:9486650, PubMed:18083576, PubMed:9430220). Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules (PubMed:9485206, PubMed:12165520). Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions (PubMed:9486650, PubMed:9430220, PubMed:9485206, PubMed:30860984). Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity (PubMed:12387742). On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens (PubMed:18064301). In HLA-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion (PubMed:30503213, PubMed:30860984). Taurus_UMD|evm.model.AC_000162.1.884 Q95MI5 NKG2A_PANTR 55.556 0.983122 1.01717 KLRC1 - NKG2-A/NKG2-B type II integral membrane protein - Pan troglodytes (Chimpanzee) - KLRC1 gene Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule MHC-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Upon MHC-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions. Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity. On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens. In MHC-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion. Taurus_UMD|evm.model.AC_000162.1.885 Q149M0 CL12B_MOUSE 37.736 0.466346 0.756364 Clec12b - C-type lectin domain family 12 member B - Mus musculus (Mouse) - Clec12b gene Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases (By similarity). Taurus_UMD|evm.model.AC_000162.1.886 P26715 NKG2A_HUMAN 60.606 0.113879 1.20601 KLRC1 - NKG2-A/NKG2-B type II integral membrane protein - Homo sapiens (Human) - KLRC1 gene Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self (PubMed:9486650, PubMed:18083576, PubMed:9430220). Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules (PubMed:9485206, PubMed:12165520). Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions (PubMed:9486650, PubMed:9430220, PubMed:9485206, PubMed:30860984). Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity (PubMed:12387742). On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens (PubMed:18064301). In HLA-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion (PubMed:30503213, PubMed:30860984). Taurus_UMD|evm.model.AC_000162.1.887 P26715 NKG2A_HUMAN 41.026 0.27451 1.09442 KLRC1 - NKG2-A/NKG2-B type II integral membrane protein - Homo sapiens (Human) - KLRC1 gene Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self (PubMed:9486650, PubMed:18083576, PubMed:9430220). Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules (PubMed:9485206, PubMed:12165520). Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions (PubMed:9486650, PubMed:9430220, PubMed:9485206, PubMed:30860984). Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity (PubMed:12387742). On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens (PubMed:18064301). In HLA-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion (PubMed:30503213, PubMed:30860984). Taurus_UMD|evm.model.AC_000162.1.888 Q9GLF5 NKG2D_PIG 39.655 0.768116 0.32243 KLRK1 - NKG2-D type II integral membrane protein - Sus scrofa (Pig) - KLRK1 gene Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins (By similarity). Taurus_UMD|evm.model.AC_000162.1.889 B2KG20 KLRI1_MOUSE 42.570 0.991903 0.995968 Klri1 - Killer cell lectin-like receptor subfamily I member 1 - Mus musculus (Mouse) - Klri1 gene Lectin-like receptor for natural killer (NK) cells. Heterodimer formation with KLRE1 mediates inhibition of NK cell cytolytic activity. Taurus_UMD|evm.model.AC_000162.1.890 P26715 NKG2A_HUMAN 56.410 0.983051 1.01288 KLRC1 - NKG2-A/NKG2-B type II integral membrane protein - Homo sapiens (Human) - KLRC1 gene Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self (PubMed:9486650, PubMed:18083576, PubMed:9430220). Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules (PubMed:9485206, PubMed:12165520). Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions (PubMed:9486650, PubMed:9430220, PubMed:9485206, PubMed:30860984). Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity (PubMed:12387742). On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens (PubMed:18064301). In HLA-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion (PubMed:30503213, PubMed:30860984). Taurus_UMD|evm.model.AC_000162.1.892 Q9GLF5 NKG2D_PIG 72.000 0.365672 0.626168 KLRK1 - NKG2-D type II integral membrane protein - Sus scrofa (Pig) - KLRK1 gene Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins (By similarity). Taurus_UMD|evm.model.AC_000162.1.893 Q8CJC7 KLRE1_MOUSE 55.462 0.971193 1.07522 Klre1 - Killer cell lectin-like receptor subfamily E member 1 - Mus musculus (Mouse) - Klre1 gene Lectin-like receptor for natural killer (NK) cells (PubMed:14707119, PubMed:15069013, PubMed:18713988). Can either inhibit or activate NK cell cytotoxic activity, depending on its binding partner (PubMed:14707119, PubMed:15069013, PubMed:18713988). Heterodimer formation with KLRI1 mediates NK cell inhibition whereas heterodimer formation with KLRI2 mediates NK cell activation (PubMed:18713988). Plays a role in allogeneic recognition by the immune system (PubMed:14707119, PubMed:15069013). Taurus_UMD|evm.model.AC_000162.1.894 Q5BIZ2 GBRL1_XENTR 100.000 0.983051 1.00855 gabarapl1 - Gamma-aminobutyric acid receptor-associated protein-like 1 precursor - Xenopus tropicalis (Western clawed frog) - gabarapl1 gene Involved in autophagy. Taurus_UMD|evm.model.AC_000162.1.895 Q0VBF2 TM52B_MOUSE 84.211 0.928962 0.983871 Tmem52b - Transmembrane protein 52B precursor - Mus musculus (Mouse) - Tmem52b gene Taurus_UMD|evm.model.AC_000162.1.896 P79391 OLR1_BOVIN 98.535 0.992701 1.01481 OLR1 - Oxidized low-density lipoprotein receptor 1 - Bos taurus (Bovine) - OLR1 gene Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. Taurus_UMD|evm.model.AC_000162.1.897 Q49BZ4 CLC7A_BOVIN 99.595 0.991935 1.00405 CLEC7A - C-type lectin domain family 7 member A - Bos taurus (Bovine) - CLEC7A gene Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans. Taurus_UMD|evm.model.AC_000162.1.898 Q0VCS6 CLC1A_BOVIN 100.000 0.992832 1.0036 CLEC1A - C-type lectin domain family 1 member A - Bos taurus (Bovine) - CLEC1A gene Taurus_UMD|evm.model.AC_000162.1.899 Q6UXN8 CLC9A_HUMAN 70.954 0.84507 1.17842 CLEC9A - C-type lectin domain family 9 member A - Homo sapiens (Human) - CLEC9A gene Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. Taurus_UMD|evm.model.AC_000162.1.900 Q9P126 CLC1B_HUMAN 68.421 0.986784 0.991266 CLEC1B - C-type lectin domain family 1 member B - Homo sapiens (Human) - CLEC1B gene C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485). Taurus_UMD|evm.model.AC_000162.1.901 Q2NL33 CL12B_BOVIN 98.936 0.37931 1.78623 CLEC12B - C-type lectin domain family 12 member B - Bos taurus (Bovine) - CLEC12B gene Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases (By similarity). Taurus_UMD|evm.model.AC_000162.1.903 Q8C1T8 CLC2H_MOUSE 38.053 0.565657 0.908257 Clec2h - C-type lectin domain family 2 member H - Mus musculus (Mouse) - Clec2h gene Lectin-type cell surface receptor. Taurus_UMD|evm.model.AC_000162.1.904 D3W0D1 KLRF2_HUMAN 64.322 0.99 0.966184 KLRF2 - Killer cell lectin-like receptor subfamily F member 2 - Homo sapiens (Human) - KLRF2 gene C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A. Taurus_UMD|evm.model.AC_000162.1.905 Q92478 CLC2B_HUMAN 53.571 0.769663 1.19463 CLEC2B - C-type lectin domain family 2 member B - Homo sapiens (Human) - CLEC2B gene external side of plasma membrane, integral component of plasma membrane, plasma membrane, carbohydrate binding, identical protein binding, regulation of immune response Taurus_UMD|evm.model.AC_000162.1.906 A4KWA6 CL2D3_RAT 59.649 0.543689 0.81746 Clec2d3 - C-type lectin domain family 2 member D3 - Rattus norvegicus (Rat) - Clec2d3 gene Lectin-type cell surface receptor. Taurus_UMD|evm.model.AC_000162.1.907 Q9D676 CLC2G_MOUSE 53.191 0.22549 0.758364 Clec2g - C-type lectin domain family 2 member G - Mus musculus (Mouse) - Clec2g gene Inhibits osteoclast formation. Taurus_UMD|evm.model.AC_000162.1.908 A4KWA5 CL2D2_RAT 54.658 0.815385 0.83691 Clec2d2 - C-type lectin domain family 2 member D2 - Rattus norvegicus (Rat) - Clec2d2 gene Lectin-type cell surface receptor. Taurus_UMD|evm.model.AC_000162.1.909 Q148C9 HEBP1_BOVIN 98.429 0.989583 1.00524 HEBP1 - Heme-binding protein 1 - Bos taurus (Bovine) - HEBP1 gene May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity). Taurus_UMD|evm.model.AC_000162.1.910 Q07108 CD69_HUMAN 62.312 0.980198 1.01508 CD69 - Early activation antigen CD69 - Homo sapiens (Human) - CD69 gene Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. Taurus_UMD|evm.model.AC_000162.1.911 Q8IZS7 CLCL1_HUMAN 66.071 0.25463 1.29341 CLECL1 - C-type lectin-like domain family 1 - Homo sapiens (Human) - CLECL1 gene May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response. Taurus_UMD|evm.model.AC_000162.1.912 D3W0D1 KLRF2_HUMAN 43.220 0.554502 1.01932 KLRF2 - Killer cell lectin-like receptor subfamily F member 2 - Homo sapiens (Human) - KLRF2 gene C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A. Taurus_UMD|evm.model.AC_000162.1.913 Q0H8B9 CL2DB_RAT 52.299 0.822967 1.00966 Clec2d11 - C-type lectin domain family 2 member D11 - Rattus norvegicus (Rat) - Clec2d11 gene Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis. Taurus_UMD|evm.model.AC_000162.1.914 Q6IE36 OVOS2_HUMAN 70.140 0.939615 1.05237 OVOS2 - Ovostatin homolog 2 precursor - Homo sapiens (Human) - OVOS2 gene Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. Taurus_UMD|evm.model.AC_000162.1.915 Q61838 PZP_MOUSE 67.598 0.667604 0.951839 Pzp - Pregnancy zone protein precursor - Mus musculus (Mouse) - Pzp gene Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Taurus_UMD|evm.model.AC_000162.1.916 Q7SIH1 A2MG_BOVIN 100.000 0.998676 1.00066 A2M - Alpha-2-macroglobulin precursor - Bos taurus (Bovine) - A2M gene Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Taurus_UMD|evm.model.AC_000162.1.917 Q96E93 KLRG1_HUMAN 46.154 0.928962 0.938462 KLRG1 - Killer cell lectin-like receptor subfamily G member 1 - Homo sapiens (Human) - KLRG1 gene Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. Taurus_UMD|evm.model.AC_000162.1.918 P11456 MPRD_BOVIN 100.000 0.992832 1 M6PR - Cation-dependent mannose-6-phosphate receptor precursor - Bos taurus (Bovine) - M6PR gene Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Taurus_UMD|evm.model.AC_000162.1.919 P78364 PHC1_HUMAN 94.627 0.405691 2.4502 PHC1 - Polyhomeotic-like protein 1 - Homo sapiens (Human) - PHC1 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression. Taurus_UMD|evm.model.AC_000162.1.920 Q0VCE9 RIMKB_BOVIN 100.000 0.909091 0.797927 RIMKLB - Beta-citrylglutamate synthase B - Bos taurus (Bovine) - RIMKLB gene Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate. Taurus_UMD|evm.model.AC_000162.1.921 Q28022 MFAP5_BOVIN 99.412 0.642586 1.54706 MFAP5 - Microfibrillar-associated protein 5 precursor - Bos taurus (Bovine) - MFAP5 gene May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils (By similarity). Taurus_UMD|evm.model.AC_000162.1.922 Q2PT36 AICDA_BOVIN 99.301 0.8875 0.80402 AICDA - Single-stranded DNA cytosine deaminase - Bos taurus (Bovine) - AICDA gene Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Taurus_UMD|evm.model.AC_000162.1.924 P41238 ABEC1_HUMAN 74.713 0.96648 0.758475 APOBEC1 - C->U-editing enzyme APOBEC-1 - Homo sapiens (Human) - APOBEC1 gene Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Taurus_UMD|evm.model.AC_000162.1.925 Q9NR23 GDF3_HUMAN 77.869 0.994521 1.00275 GDF3 - Growth/differentiation factor 3 precursor - Homo sapiens (Human) - GDF3 gene Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto (PubMed:21805089). Taurus_UMD|evm.model.AC_000162.1.926 A9Q1J7 DPPA3_BOVIN 100.000 0.987805 1.00613 DPPA3 - Developmental pluripotency-associated protein 3 - Bos taurus (Bovine) - DPPA3 gene Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity). Taurus_UMD|evm.model.AC_000162.1.927 A5GFY4 NELFD_PIG 78.571 0.994872 0.991525 NELFCD - Negative elongation factor D - Sus scrofa (Pig) - NELFCD gene Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). Taurus_UMD|evm.model.AC_000162.1.928 Q4JM65 NANOG_BOVIN 100.000 0.665924 1.49667 NANOG - Homeobox protein NANOG - Bos taurus (Bovine) - NANOG gene Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator and repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity). Taurus_UMD|evm.model.AC_000162.1.929 P58352 GTR3_BOVIN 99.592 0.983903 1.00607 SLC2A3 - Solute carrier family 2, facilitated glucose transporter member 3 - Bos taurus (Bovine) - SLC2A3 gene Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Taurus_UMD|evm.model.AC_000162.1.930 Q9P0K8 FOXJ2_HUMAN 88.174 0.996441 0.979094 FOXJ2 - Forkhead box protein J2 - Homo sapiens (Human) - FOXJ2 gene Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity). Taurus_UMD|evm.model.AC_000162.1.931 Q16581 C3AR_HUMAN 71.310 0.989627 1 C3AR1 - C3a anaphylatoxin chemotactic receptor - Homo sapiens (Human) - C3AR1 gene Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. Taurus_UMD|evm.model.AC_000162.1.932 Q3T093 NECP1_BOVIN 100.000 0.992754 1.00364 NECAP1 - Adaptin ear-binding coat-associated protein 1 - Bos taurus (Bovine) - NECAP1 gene Involved in endocytosis. Taurus_UMD|evm.model.AC_000162.1.933 Q9UMR7 CLC4A_HUMAN 60.166 0.991597 1.00422 CLEC4A - C-type lectin domain family 4 member A - Homo sapiens (Human) - CLEC4A gene C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner (PubMed:27015765). Involved in regulating immune reactivity (PubMed:18258799, PubMed:10438934). Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13 (PubMed:18258799, PubMed:20530286). In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production (PubMed:18258799). May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation (PubMed:10438934). Taurus_UMD|evm.model.AC_000162.1.934 P84104 SRSF3_MOUSE 99.390 0.987879 1.0061 Srsf3 - Serine/arginine-rich splicing factor 3 - Mus musculus (Mouse) - Srsf3 gene Splicing factor that specifically promotes exon-inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. Also functions as export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. RNA-binding is semi-sequence specific. Taurus_UMD|evm.model.AC_000162.1.935 Q3LUH2 CLC6A_BOVIN 99.515 0.990338 1.00485 CLEC6A - C-type lectin domain family 6 member A - Bos taurus (Bovine) - CLEC6A gene Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (By similarity). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity). Taurus_UMD|evm.model.AC_000162.1.936 Q9ULY5 CLC4E_HUMAN 76.020 0.514512 1.73059 CLEC4E - C-type lectin domain family 4 member E - Homo sapiens (Human) - CLEC4E gene Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:18509109, PubMed:23602766). The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions (PubMed:23602766, PubMed:24101491). Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation (By similarity). Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue (By similarity). Taurus_UMD|evm.model.AC_000162.1.937 P85521 C163A_BOVIN 100.000 0.992799 0.984057 CD163 - Scavenger receptor cysteine-rich type 1 protein M130 precursor - Bos taurus (Bovine) - CD163 gene Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). Taurus_UMD|evm.model.AC_000162.1.939 P30205 WC11_BOVIN 82.531 0.971585 0.637187 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.940 P30205 WC11_BOVIN 87.883 0.99858 0.980501 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.941 P30205 WC11_BOVIN 85.625 0.998611 1.00279 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.942 P30205 WC11_BOVIN 68.156 0.502308 0.905292 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.943 P30205 WC11_BOVIN 61.557 0.54039 0.5 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.944 P30205 WC11_BOVIN 61.238 0.985789 0.931058 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.945 P30205 WC11_BOVIN 63.077 0.335079 0.133008 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.946 P30205 WC11_BOVIN 78.431 0.489157 0.288997 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.947 P30205 WC11_BOVIN 49.000 0.0838273 0.822423 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.948 P30205 WC11_BOVIN 76.286 0.745203 0.653203 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.949 P30205 WC11_BOVIN 76.633 0.989873 0.27507 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.951 P30205 WC11_BOVIN 82.563 0.743215 1.33426 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.952 Q99627 CSN8_HUMAN 92.823 0.990476 1.00478 COPS8 - COP9 signalosome complex subunit 8 - Homo sapiens (Human) - COPS8 gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Taurus_UMD|evm.model.AC_000162.1.953 P30205 WC11_BOVIN 81.216 0.953767 0.406685 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.954 P30205 WC11_BOVIN 76.551 0.338676 1.3468 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.955 P30205 WC11_BOVIN 80.034 0.893761 0.412953 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.956 P30205 WC11_BOVIN 82.011 0.703852 0.867688 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.957 Q99627 CSN8_HUMAN 92.823 0.990476 1.00478 COPS8 - COP9 signalosome complex subunit 8 - Homo sapiens (Human) - COPS8 gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Taurus_UMD|evm.model.AC_000162.1.958 P30205 WC11_BOVIN 83.746 0.713924 0.27507 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.959 P30205 WC11_BOVIN 96.601 0.729953 1.3461 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.960 D3ZTX0 TMED7_RAT 93.023 0.6 0.309735 Tmed7 - Transmembrane emp24 domain-containing protein 7 precursor - Rattus norvegicus (Rat) - Tmed7 gene Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications (By similarity). Taurus_UMD|evm.model.AC_000162.1.961 Q1RMV0 PEX5_BOVIN 100.000 0.99688 1.00156 PEX5 - Peroxisomal targeting signal 1 receptor - Bos taurus (Bovine) - PEX5 gene Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Taurus_UMD|evm.model.AC_000162.1.962 Q0VCN6 CSTN3_BOVIN 100.000 0.997912 1.00104 CLSTN3 - Calsyntenin-3 precursor - Bos taurus (Bovine) - CLSTN3 gene May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. Taurus_UMD|evm.model.AC_000162.1.963 P82708 RET5_BOVIN 100.000 0.985294 1.00741 RBP5 - Retinol-binding protein 5 - Bos taurus (Bovine) - RBP5 gene Intracellular transport of retinol. Taurus_UMD|evm.model.AC_000162.1.964 Q5R544 C1R_PONAB 75.000 0.10022 1.28794 C1R - Complement C1r subcomponent precursor - Pongo abelii (Sumatran orangutan) - C1R gene C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. Taurus_UMD|evm.model.AC_000162.1.965 P00736 C1R_HUMAN 81.481 0.363372 1.46383 C1R - Complement C1r subcomponent precursor - Homo sapiens (Human) - C1R gene C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. Taurus_UMD|evm.model.AC_000162.1.966 Q5R544 C1R_PONAB 81.250 0.984594 1.01277 C1R - Complement C1r subcomponent precursor - Pongo abelii (Sumatran orangutan) - C1R gene C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. Taurus_UMD|evm.model.AC_000162.1.967 Q0VCX1 C1S_BOVIN 99.855 0.988506 1.01016 C1S - Complement C1s subcomponent precursor - Bos taurus (Bovine) - C1S gene C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). Taurus_UMD|evm.model.AC_000162.1.968 Q3SZL3 MBOA5_BOVIN 97.561 0.512821 0.160825 LPCAT3 - Lysophospholipid acyltransferase 5 - Bos taurus (Bovine) - LPCAT3 gene Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle. Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (By similarity). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency. Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus. Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Downregulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins. In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly. In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity). Taurus_UMD|evm.model.AC_000162.1.969 Q3SZL3 MBOA5_BOVIN 99.771 0.95614 0.940206 LPCAT3 - Lysophospholipid acyltransferase 5 - Bos taurus (Bovine) - LPCAT3 gene Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle. Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (By similarity). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency. Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus. Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Downregulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins. In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly. In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity). Taurus_UMD|evm.model.AC_000162.1.970 Q92979 NEP1_HUMAN 91.803 0.698276 1.42623 EMG1 - Ribosomal RNA small subunit methyltransferase NEP1 - Homo sapiens (Human) - EMG1 gene S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity). Taurus_UMD|evm.model.AC_000162.1.971 Q2HJ97 PHB2_BOVIN 93.312 0.993651 1.05351 PHB2 - Prohibitin-2 - Bos taurus (Bovine) - PHB2 gene Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. Taurus_UMD|evm.model.AC_000162.1.972 P29350 PTN6_HUMAN 95.946 0.988294 1.00504 PTPN6 - Tyrosine-protein phosphatase non-receptor type 6 - Homo sapiens (Human) - PTPN6 gene Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. Taurus_UMD|evm.model.AC_000162.1.973 Q32KM2 C10_BOVIN 100.000 0.984252 0.962121 Protein C10 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000162.1.974 Q5IS70 ATN1_PANTR 95.114 0.998311 0.998314 ATN1 - Atrophin-1 - Pan troglodytes (Chimpanzee) - ATN1 gene Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Recruits NR2E1 to repress transcription. Has some intrinsic repression activity. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Taurus_UMD|evm.model.AC_000162.1.975 P09104 ENOG_HUMAN 98.618 0.995402 1.0023 ENO2 - Gamma-enolase - Homo sapiens (Human) - ENO2 gene Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). Taurus_UMD|evm.model.AC_000162.1.976 Q32KP2 LRC23_BOVIN 99.708 0.994169 1.00292 LRRC23 - Leucine-rich repeat-containing protein 23 - Bos taurus (Bovine) - LRRC23 gene Taurus_UMD|evm.model.AC_000162.1.977 Q99619 SPSB2_HUMAN 92.776 0.891156 1.11787 SPSB2 - SPRY domain-containing SOCS box protein 2 - Homo sapiens (Human) - SPSB2 gene Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Taurus_UMD|evm.model.AC_000162.1.978 Q5E956 TPIS_BOVIN 100.000 0.864111 1.15261 TPI1 - Triosephosphate isomerase - Bos taurus (Bovine) - TPI1 gene Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. Taurus_UMD|evm.model.AC_000162.1.979 P56399 UBP5_MOUSE 98.135 0.997672 1.00117 Usp5 - Ubiquitin carboxyl-terminal hydrolase 5 - Mus musculus (Mouse) - Usp5 gene Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity (By similarity). Taurus_UMD|evm.model.AC_000162.1.980 Q99618 CDCA3_HUMAN 80.224 0.992481 0.992537 CDCA3 - Cell division cycle-associated protein 3 - Homo sapiens (Human) - CDCA3 gene F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). Taurus_UMD|evm.model.AC_000162.1.981 P79147 GBB3_CANLF 97.941 0.994135 1.00294 GNB3 - Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 - Canis lupus familiaris (Dog) - GNB3 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Taurus_UMD|evm.model.AC_000162.1.982 Q16538 GP162_HUMAN 97.500 0.419293 1.78061 GPR162 - Probable G-protein coupled receptor 162 - Homo sapiens (Human) - GPR162 gene Orphan receptor. Taurus_UMD|evm.model.AC_000162.1.983 P18627 LAG3_HUMAN 72.691 0.460577 1.98095 LAG3 - Lymphocyte activation gene 3 protein precursor - Homo sapiens (Human) - LAG3 gene Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:8647185). Taurus_UMD|evm.model.AC_000162.1.984 P04550 PTMS_RAT 91.954 0.86 0.980392 Ptms - Parathymosin - Rattus norvegicus (Rat) - Ptms gene Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections. Taurus_UMD|evm.model.AC_000162.1.985 Q15773 MLF2_HUMAN 97.581 0.991935 1 MLF2 - Myeloid leukemia factor 2 - Homo sapiens (Human) - MLF2 gene cytoplasm, membrane, nucleus, regulation of transcription, DNA-templated Taurus_UMD|evm.model.AC_000162.1.986 P61247 RS3A_HUMAN 94.444 0.967568 0.700758 RPS3A - 40S ribosomal protein S3a - Homo sapiens (Human) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Taurus_UMD|evm.model.AC_000162.1.987 Q5R762 CSN7A_PONAB 99.636 0.992754 1.00364 COPS7A - COP9 signalosome complex subunit 7a - Pongo abelii (Sumatran orangutan) - COPS7A gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Taurus_UMD|evm.model.AC_000162.1.988 Q5U2P6 PIANP_RAT 97.845 0.249191 3.40809 Pianp - PILR alpha-associated neural protein precursor - Rattus norvegicus (Rat) - Pianp gene Acts as a ligand for PILRA in neuronal tissues, where it may be involved in immune regulation. Taurus_UMD|evm.model.AC_000162.1.989 Q3T095 ING4_BOVIN 99.597 0.815182 1.22177 ING4 - Inhibitor of growth protein 4 - Bos taurus (Bovine) - ING4 gene Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (By similarity). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). Taurus_UMD|evm.model.AC_000162.1.990 Q29016 ACRBP_PIG 89.210 0.950276 1.00742 ACRBP - Acrosin-binding protein precursor - Sus scrofa (Pig) - ACRBP gene Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome (PubMed:8144514). Involved also in the acrosome formation (By similarity). Taurus_UMD|evm.model.AC_000162.1.991 Q3ZC80 LPAR5_BOVIN 100.000 0.994565 1.00272 LPAR5 - Lysophosphatidic acid receptor 5 - Bos taurus (Bovine) - LPAR5 gene Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Taurus_UMD|evm.model.AC_000162.1.992 Q14839 CHD4_HUMAN 98.431 0.688608 1.44613 CHD4 - Chromodomain-helicase-DNA-binding protein 4 - Homo sapiens (Human) - CHD4 gene Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Taurus_UMD|evm.model.AC_000162.1.993 Q8BXL9 IFFO1_MOUSE 93.530 0.886513 1.08185 Iffo1 - Non-homologous end joining factor IFFO1 - Mus musculus (Mouse) - Iffo1 gene Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that will relocalize to the DSB sites in a XRCC4-dependent manner and promote the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606). Taurus_UMD|evm.model.AC_000162.1.994 P10096 G3P_BOVIN 100.000 0.994012 1.003 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Bos taurus (Bovine) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Taurus_UMD|evm.model.AC_000162.1.995 Q15021 CND1_HUMAN 87.081 0.998569 0.997859 NCAPD2 - Condensin complex subunit 1 - Homo sapiens (Human) - NCAPD2 gene Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). Taurus_UMD|evm.model.AC_000162.1.996 P0C2B6 RM51_BOVIN 100.000 0.984496 1.00781 MRPL51 - 39S ribosomal protein L51, mitochondrial precursor - Bos taurus (Bovine) - MRPL51 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, structural constituent of ribosome, mitochondrial translation, translation Taurus_UMD|evm.model.AC_000162.1.998 Q0V7N0 VAMP1_BOVIN 100.000 0.590426 1.59322 VAMP1 - Vesicle-associated membrane protein 1 - Bos taurus (Bovine) - VAMP1 gene Involved in the targeting and/or fusion of transport vesicles to their target membrane. Taurus_UMD|evm.model.AC_000162.1.999 Q5R8H1 TPSNR_PONAB 75.349 0.959368 0.946581 TAPBPL - Tapasin-related protein precursor - Pongo abelii (Sumatran orangutan) - TAPBPL gene Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression. Taurus_UMD|evm.model.AC_000162.1.1000 P26842 CD27_HUMAN 72.656 0.976 0.961538 CD27 - CD27 antigen precursor - Homo sapiens (Human) - CD27 gene Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. Taurus_UMD|evm.model.AC_000162.1.1001 P36941 TNR3_HUMAN 69.953 0.986014 0.986207 LTBR - Tumor necrosis factor receptor superfamily member 3 precursor - Homo sapiens (Human) - LTBR gene Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. Taurus_UMD|evm.model.AC_000162.1.1002 P55270 SCNNA_BOVIN 91.692 0.948012 1.00615 SCNN1A - Amiloride-sensitive sodium channel subunit alpha - Bos taurus (Bovine) - SCNN1A gene Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Taurus_UMD|evm.model.AC_000162.1.1003 O19131 TNR1A_BOVIN 100.000 0.993644 1.00212 TNFRSF1A - Tumor necrosis factor receptor superfamily member 1A precursor - Bos taurus (Bovine) - TNFRSF1A gene Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). Taurus_UMD|evm.model.AC_000162.1.1004 Q3KR16 PKHG6_HUMAN 74.874 0.997406 0.975949 PLEKHG6 - Pleckstrin homology domain-containing family G member 6 - Homo sapiens (Human) - PLEKHG6 gene Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. Taurus_UMD|evm.model.AC_000162.1.1005 P30932 CD9_BOVIN 100.000 0.89823 1 CD9 - CD9 antigen - Bos taurus (Bovine) - CD9 gene Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (By similarity). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (By similarity). Taurus_UMD|evm.model.AC_000162.1.1006 P80012 VWF_BOVIN 91.277 0.331074 2.99146 VWF - von Willebrand factor precursor - Bos taurus (Bovine) - VWF gene Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Taurus_UMD|evm.model.AC_000162.1.1007 Q3ZBN8 TIM14_BOVIN 97.414 0.982906 1.00862 DNAJC19 - Mitochondrial import inner membrane translocase subunit TIM14 - Bos taurus (Bovine) - DNAJC19 gene Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). Taurus_UMD|evm.model.AC_000162.1.1008 Q9NQ90 ANO2_HUMAN 91.551 0.990405 0.935194 ANO2 - Anoctamin-2 - Homo sapiens (Human) - ANO2 gene Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. Taurus_UMD|evm.model.AC_000162.1.1009 Q08DT3 NTF3_BOVIN 100.000 0.965517 1.03162 NTF3 - Neurotrophin-3 precursor - Bos taurus (Bovine) - NTF3 gene Seems to promote the survival of visceral and proprioceptive sensory neurons. Taurus_UMD|evm.model.AC_000162.1.1011 P79197 KCNA5_MUSPF 90.216 0.996661 0.996672 KCNA5 - Potassium voltage-gated channel subfamily A member 5 - Mustela putorius furo (European domestic ferret) - KCNA5 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (By similarity). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (By similarity). May play a role in regulating the secretion of insulin in normal pancreatic islets (By similarity). Taurus_UMD|evm.model.AC_000162.1.1012 Q9GZR5 ELOV4_HUMAN 47.867 0.981221 0.678344 ELOVL4 - Elongation of very long chain fatty acids protein 4 - Homo sapiens (Human) - ELOVL4 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. Taurus_UMD|evm.model.AC_000162.1.1013 Q09470 KCNA1_HUMAN 96.566 0.995968 1.00202 KCNA1 - Potassium voltage-gated channel subfamily A member 1 - Homo sapiens (Human) - KCNA1 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:19903818). Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:17156368). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12077175, PubMed:17156368). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed:12077175, PubMed:17156368). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:19912772, PubMed:19968958, PubMed:19307729, PubMed:19903818). In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368). Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (By similarity). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) release (By similarity). Plays a role in regulating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regulation of heart contraction (By similarity). Required for normal neuromuscular responses (PubMed:11026449, PubMed:17136396). Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (By similarity). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (By similarity). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (By similarity). Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (PubMed:23903368, PubMed:19307729). Taurus_UMD|evm.model.AC_000162.1.1015 P17658 KCNA6_HUMAN 95.660 0.996219 1 KCNA6 - Potassium voltage-gated channel subfamily A member 6 - Homo sapiens (Human) - KCNA6 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305). Taurus_UMD|evm.model.AC_000162.1.1016 Q9NY28 GALT8_HUMAN 73.734 0.993701 0.99686 GALNT8 - Probable polypeptide N-acetylgalactosaminyltransferase 8 - Homo sapiens (Human) - GALNT8 gene Probably catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Taurus_UMD|evm.model.AC_000162.1.1017 P34943 NDUA9_BOVIN 100.000 0.994751 1.00263 NDUFA9 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor - Bos taurus (Bovine) - NDUFA9 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000162.1.1018 O77797 AKAP3_BOVIN 99.767 0.997672 1.00117 AKAP3 - A-kinase anchor protein 3 - Bos taurus (Bovine) - AKAP3 gene May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Taurus_UMD|evm.model.AC_000162.1.1019 Q9NR20 DYRK4_HUMAN 80.998 0.752533 1.32885 DYRK4 - Dual specificity tyrosine-phosphorylation-regulated kinase 4 - Homo sapiens (Human) - DYRK4 gene Possible non-essential role in spermiogenesis. Taurus_UMD|evm.model.AC_000162.1.1020 Q96B01 R51A1_HUMAN 63.636 0.987768 0.928977 RAD51AP1 - RAD51-associated protein 1 - Homo sapiens (Human) - RAD51AP1 gene Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:9396801, PubMed:17996711, PubMed:22375013, PubMed:17996710). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27463890, PubMed:27239033, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801). Taurus_UMD|evm.model.AC_000162.1.1021 Q5RD58 CL004_PONAB 96.196 0.996383 1.00181 Protein C12orf4 homolog - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000162.1.1022 Q96B01 R51A1_HUMAN 63.636 0.987768 0.928977 RAD51AP1 - RAD51-associated protein 1 - Homo sapiens (Human) - RAD51AP1 gene Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:9396801, PubMed:17996711, PubMed:22375013, PubMed:17996710). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27463890, PubMed:27239033, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801). Taurus_UMD|evm.model.AC_000162.1.1023 Q5RD58 CL004_PONAB 95.792 0.815057 1.10688 Protein C12orf4 homolog - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000162.1.1024 P10767 FGF6_HUMAN 92.788 0.990431 1.00481 FGF6 - Fibroblast growth factor 6 precursor - Homo sapiens (Human) - FGF6 gene Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration. Taurus_UMD|evm.model.AC_000162.1.1025 Q9GZV9 FGF23_HUMAN 76.892 0.987805 0.98008 FGF23 - Fibroblast growth factor 23 precursor - Homo sapiens (Human) - FGF23 gene Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Taurus_UMD|evm.model.AC_000162.1.1026 Q1JQA7 TIGAR_BOVIN 100.000 0.99262 1.0037 TIGAR - Fructose-2,6-bisphosphatase TIGAR - Bos taurus (Bovine) - TIGAR gene Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (By similarity). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity. In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage. Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation. Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions. Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner. Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses. Involved in intestinal tumor progression. Taurus_UMD|evm.model.AC_000162.1.1027 Q0P5D3 CCND2_BOVIN 100.000 0.663594 1.50173 CCND2 - G1/S-specific cyclin-D2 - Bos taurus (Bovine) - CCND2 gene Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). Taurus_UMD|evm.model.AC_000162.1.1030 Q9NR21 PAR11_HUMAN 95.181 0.831658 1.17751 PARP11 - Protein mono-ADP-ribosyltransferase PARP11 - Homo sapiens (Human) - PARP11 gene Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:25673562). Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). Taurus_UMD|evm.model.AC_000162.1.1032 Q9BSW2 EFC4B_HUMAN 82.650 0.997238 0.990424 CRACR2A - EF-hand calcium-binding domain-containing protein 4B - Homo sapiens (Human) - CRACR2A gene Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. Taurus_UMD|evm.model.AC_000162.1.1033 Q9NR22 ANM8_HUMAN 98.945 0.994737 0.964467 PRMT8 - Protein arginine N-methyltransferase 8 - Homo sapiens (Human) - PRMT8 gene S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer (PubMed:16051612, PubMed:17925405, PubMed:26876602, PubMed:26529540). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS (PubMed:18320585). Taurus_UMD|evm.model.AC_000162.1.1034 Q0VC33 TSN11_BOVIN 100.000 0.992126 1.00395 TSPAN11 - Tetraspanin-11 - Bos taurus (Bovine) - TSPAN11 gene integral component of plasma membrane, cell migration Taurus_UMD|evm.model.AC_000162.1.1035 B3VSC2 TSN9_SHEEP 97.490 0.719033 1.38494 TSPAN9 - Tetraspanin-9 - Ovis aries (Sheep) - TSPAN9 gene Taurus_UMD|evm.model.AC_000162.1.1037 Q6QAJ8 TM220_HUMAN 47.917 0.633333 0.9375 TMEM220 - Transmembrane protein 220 - Homo sapiens (Human) - TMEM220 gene Taurus_UMD|evm.model.AC_000162.1.1038 Q15561 TEAD4_HUMAN 95.853 0.771836 1.29263 TEAD4 - Transcriptional enhancer factor TEF-3 - Homo sapiens (Human) - TEAD4 gene Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. Taurus_UMD|evm.model.AC_000162.1.1039 O88413 TULP3_MOUSE 78.879 0.99569 1.0087 Tulp3 - Tubby-related protein 3 - Mus musculus (Mouse) - Tulp3 gene Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes. Taurus_UMD|evm.model.AC_000162.1.1040 Q1LZE2 RHNO1_BOVIN 100.000 0.991736 1.00415 RHNO1 - RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 - Bos taurus (Bovine) - RHNO1 gene Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation (By similarity). Taurus_UMD|evm.model.AC_000162.1.1041 Q08050 FOXM1_HUMAN 77.705 0.996063 0.998689 FOXM1 - Forkhead box protein M1 - Homo sapiens (Human) - FOXM1 gene Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. Taurus_UMD|evm.model.AC_000162.1.1042 A6NCN8 TEX52_HUMAN 69.286 0.965398 0.947541 TEX52 - Testis-expressed protein 52 - Homo sapiens (Human) - TEX52 gene Taurus_UMD|evm.model.AC_000162.1.1043 Q9BQI9 NRIP2_HUMAN 80.603 0.991416 0.829181 NRIP2 - Nuclear receptor-interacting protein 2 - Homo sapiens (Human) - NRIP2 gene Down-regulates transcriptional activation by nuclear receptors such as NR1F2. Taurus_UMD|evm.model.AC_000162.1.1044 Q27969 ITFG2_BOVIN 91.358 0.894382 0.836466 ITFG2 - KICSTOR complex protein ITFG2 - Bos taurus (Bovine) - ITFG2 gene As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. Taurus_UMD|evm.model.AC_000162.1.1045 Q9TRY0 FKBP4_BOVIN 99.782 0.995652 1.00218 FKBP4 - Peptidyl-prolyl cis-trans isomerase FKBP4 - Bos taurus (Bovine) - FKBP4 gene Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) (By similarity). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening (By similarity). Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria (By similarity). Taurus_UMD|evm.model.AC_000162.1.1046 Q96FC9 DDX11_HUMAN 77.985 0.82206 0.990722 DDX11 - ATP-dependent DNA helicase DDX11 - Homo sapiens (Human) - DDX11 gene DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:18499658, PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Shows also ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three-stranded D-loop DNA molecules (PubMed:22102414, PubMed:26503245). Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage (PubMed:23797032). Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity (PubMed:26503245). Cooperates also with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation (PubMed:17105772, PubMed:18499658, PubMed:20124417, PubMed:23116066, PubMed:23797032). Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis (PubMed:18499658). Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions (PubMed:27477908). Plays also a role in heterochromatin organization (PubMed:21854770). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development and prevention of aneuploidy (By similarity). Involved in melanoma cell proliferation and survival (PubMed:23116066). Associates with chromatin at DNA replication fork regions (PubMed:27477908). Binds to single- and double-stranded DNAs (PubMed:9013641, PubMed:18499658, PubMed:22102414). Taurus_UMD|evm.model.AC_000162.1.1047 A7Z063 WASH1_BOVIN 100.000 0.983264 1.01486 WASHC1 - WASH complex subunit 1 - Bos taurus (Bovine) - WASHC1 gene Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). Taurus_UMD|evm.model.AC_000162.1.1048 Q9UPP2 IQEC3_HUMAN 81.809 0.858162 0.948393 IQSEC3 - IQ motif and SEC7 domain-containing protein 3 - Homo sapiens (Human) - IQSEC3 gene Acts as a guanine nucleotide exchange factor (GEF) for ARF1. Taurus_UMD|evm.model.AC_000162.1.1049 P27799 S6A12_CANLF 87.765 0.990291 1.00651 SLC6A12 - Sodium- and chloride-dependent betaine transporter - Canis lupus familiaris (Dog) - SLC6A12 gene Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Taurus_UMD|evm.model.AC_000162.1.1051 A5PJX7 S6A13_BOVIN 100.000 0.996683 1.00166 SLC6A13 - Sodium- and chloride-dependent GABA transporter 2 - Bos taurus (Bovine) - SLC6A13 gene Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport (By similarity). Taurus_UMD|evm.model.AC_000162.1.1052 P29375 KDM5A_HUMAN 97.811 0.998817 1.00059 KDM5A - Lysine-specific demethylase 5A - Homo sapiens (Human) - KDM5A gene Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). Taurus_UMD|evm.model.AC_000162.1.1053 Q9BR77 CCD77_HUMAN 78.296 0.995943 1.01025 CCDC77 - Coiled-coil domain-containing protein 77 - Homo sapiens (Human) - CCDC77 gene centrosome, membrane Taurus_UMD|evm.model.AC_000162.1.1054 A8D8X1 RL10_SHEEP 97.872 0.0797599 5.4486 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000162.1.1055 Q9NZG7 NINJ2_HUMAN 71.324 0.957447 0.992958 NINJ2 - Ninjurin-2 - Homo sapiens (Human) - NINJ2 gene Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Taurus_UMD|evm.model.AC_000162.1.1056 Q9JIH7 WNK1_RAT 84.875 0.334454 1.11947 Wnk1 - Serine/threonine-protein kinase WNK1 - Rattus norvegicus (Rat) - Wnk1 gene Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity). Taurus_UMD|evm.model.AC_000162.1.1057 P43351 RAD52_HUMAN 67.813 0.788306 1.1866 RAD52 - DNA repair protein RAD52 homolog - Homo sapiens (Human) - RAD52 gene Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. Taurus_UMD|evm.model.AC_000162.1.1058 Q8IUD2 RB6I2_HUMAN 97.312 0.998209 1.0009 ERC1 - ELKS/Rab6-interacting/CAST family member 1 - Homo sapiens (Human) - ERC1 gene Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. Taurus_UMD|evm.model.AC_000162.1.1059 Q8BID8 FXL14_MOUSE 100.000 0.995012 1.0025 Fbxl14 - F-box/LRR-repeat protein 14 - Mus musculus (Mouse) - Fbxl14 gene Substrate-recognition component of some (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity). Taurus_UMD|evm.model.AC_000162.1.1060 Q5NVK2 WNT5B_PONAB 90.698 0.955432 1 WNT5B - Protein Wnt-5b precursor - Pongo abelii (Sumatran orangutan) - WNT5B gene Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Taurus_UMD|evm.model.AC_000162.1.1061 Q86V24 PAQR2_HUMAN 92.228 0.994832 1.00259 ADIPOR2 - Adiponectin receptor protein 2 - Homo sapiens (Human) - ADIPOR2 gene Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity). Taurus_UMD|evm.model.AC_000162.1.1062 Q7Z3S7 CA2D4_HUMAN 79.929 0.998146 0.948989 CACNA2D4 - Voltage-dependent calcium channel subunit alpha-2/delta-4 precursor - Homo sapiens (Human) - CACNA2D4 gene The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Taurus_UMD|evm.model.AC_000162.1.1063 Q3SZL6 DCP1B_BOVIN 99.828 0.996564 1.00172 DCP1B - mRNA-decapping enzyme 1B - Bos taurus (Bovine) - DCP1B gene May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). Taurus_UMD|evm.model.AC_000162.1.1064 Q13936 CAC1C_HUMAN 98.863 0.987581 0.761369 CACNA1C - Voltage-dependent L-type calcium channel subunit alpha-1C - Homo sapiens (Human) - CACNA1C gene Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:23677916). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). Taurus_UMD|evm.model.AC_000162.1.1065 P58780 ADA2_PIG 69.524 0.83871 0.243137 ADA2 - Adenosine deaminase 2 precursor - Sus scrofa (Pig) - ADA2 gene Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity (By similarity). Taurus_UMD|evm.model.AC_000162.1.1066 Q96F46 I17RA_HUMAN 66.626 0.936375 0.961894 IL17RA - Interleukin-17 receptor A precursor - Homo sapiens (Human) - IL17RA gene Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:24120361, PubMed:17911633, PubMed:18684971, PubMed:21350122). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Taurus_UMD|evm.model.AC_000162.1.1067 Q9BXW7 HDHD5_HUMAN 71.327 0.995025 0.950355 HDHD5 - Haloacid dehalogenase-like hydrolase domain-containing 5 precursor - Homo sapiens (Human) - HDHD5 gene mitochondrion, glycerophospholipid biosynthetic process Taurus_UMD|evm.model.AC_000162.1.1068 P58780 ADA2_PIG 80.337 0.880893 0.790196 ADA2 - Adenosine deaminase 2 precursor - Sus scrofa (Pig) - ADA2 gene Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity (By similarity). Taurus_UMD|evm.model.AC_000162.1.1069 Q9BXF3 CECR2_HUMAN 69.220 0.968277 0.934636 CECR2 - Cat eye syndrome critical region protein 2 - Homo sapiens (Human) - CECR2 gene Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI-type complex (PubMed:15640247, PubMed:26365797, PubMed:22464331). It thereby plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797, PubMed:22464331). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (PubMed:11827465). Taurus_UMD|evm.model.AC_000162.1.1070 P11019 VATE1_BOVIN 100.000 0.991189 1.00442 ATP6V1E1 - V-type proton ATPase subunit E 1 - Bos taurus (Bovine) - ATP6V1E1 gene Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Taurus_UMD|evm.model.AC_000162.1.1072 Q9BXK5 B2L13_HUMAN 69.184 0.995444 0.905155 BCL2L13 - Bcl-2-like protein 13 - Homo sapiens (Human) - BCL2L13 gene May promote the activation of caspase-3 and apoptosis. Taurus_UMD|evm.model.AC_000162.1.1073 Q4JHS0 BID_PIG 65.285 0.989691 1.01042 BID - BH3-interacting domain death agonist - Sus scrofa (Pig) - BID gene Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Taurus_UMD|evm.model.AC_000162.1.1074 G3MWR8 MICA3_BOVIN 100.000 0.353053 1.07806 MICAL3 - [F-actin]-monooxygenase MICAL3 - Bos taurus (Bovine) - MICAL3 gene Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and play a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. Taurus_UMD|evm.model.AC_000162.1.1076 Q7Z412 PEX26_HUMAN 77.961 0.990033 0.986885 PEX26 - Peroxisome assembly protein 26 - Homo sapiens (Human) - PEX26 gene Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence. Taurus_UMD|evm.model.AC_000162.1.1077 Q2HJB8 TBA8_BOVIN 100.000 0.995556 1.00223 TUBA8 - Tubulin alpha-8 chain - Bos taurus (Bovine) - TUBA8 gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Taurus_UMD|evm.model.AC_000162.1.1078 Q17QW1 BORG5_BOVIN 100.000 0.994475 1.00277 CDC42EP1 - Cdc42 effector protein 1 - Bos taurus (Bovine) - CDC42EP1 gene Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts (By similarity). Taurus_UMD|evm.model.AC_000162.1.1079 Q29373 LEG2_PIG 79.279 0.901639 0.99187 LGALS2 - Galectin-2 - Sus scrofa (Pig) - LGALS2 gene This protein binds beta-galactoside. Its physiological function is not yet known (By similarity). Taurus_UMD|evm.model.AC_000162.1.1080 Q9UJY5 GGA1_HUMAN 93.427 0.99685 0.99374 GGA1 - ADP-ribosylation factor-binding protein GGA1 - Homo sapiens (Human) - GGA1 gene Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15886016, PubMed:15615712). Taurus_UMD|evm.model.AC_000162.1.1081 Q6ZT62 BGIN_HUMAN 87.266 0.756484 1.02511 BARGIN - Bargin - Homo sapiens (Human) - BARGIN gene GTPase activating protein (GAP) which specifically converts GTP-bound RAC1 and CDC42 in their inactive GDP-bound form. The GAP activity is enhanced by the non-covalent binding of K-29 and K-48 polyubiquitin chains. Taurus_UMD|evm.model.AC_000162.1.1082 Q3ZBF9 PLPP_BOVIN 99.662 0.993266 1.00338 PDXP - Chronophin - Bos taurus (Bovine) - PDXP gene Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism (By similarity). Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine (PubMed:15580268). Taurus_UMD|evm.model.AC_000162.1.1083 P11116 LEG1_BOVIN 100.000 0.985294 1.00741 LGALS1 - Galectin-1 - Bos taurus (Bovine) - LGALS1 gene Lectin that binds beta-galactoside and a wide array of complex carbohydrates (PubMed:1900835, PubMed:8108426, PubMed:7773775). Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Taurus_UMD|evm.model.AC_000162.1.1084 Q2KIV0 NOL12_BOVIN 99.531 0.0884808 11.2488 NOL12 - Nucleolar protein 12 - Bos taurus (Bovine) - NOL12 gene May bind to 28S rRNA. Taurus_UMD|evm.model.AC_000162.1.1085 Q0IIJ2 H10_BOVIN 100.000 0.989744 1.00515 H1-0 - Histone H1.0 - Bos taurus (Bovine) - H1-0 gene Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division (By similarity). Taurus_UMD|evm.model.AC_000162.1.1086 Q0P5L8 KBL_BOVIN 100.000 0.995238 1.00239 GCAT - 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor - Bos taurus (Bovine) - GCAT gene mitochondrion Taurus_UMD|evm.model.AC_000162.1.1087 O60755 GALR3_HUMAN 97.778 0.875 0.695652 GALR3 - Galanin receptor type 3 - Homo sapiens (Human) - GALR3 gene Receptor for the hormone galanin (PubMed:25691535). Receptor for the hormone spexin-1 (PubMed:24517231). Taurus_UMD|evm.model.AC_000162.1.1088 Q1LZC5 ANR54_BOVIN 100.000 0.993333 1.00334 ANKRD54 - Ankyrin repeat domain-containing protein 54 - Bos taurus (Bovine) - ANKRD54 gene Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation. Taurus_UMD|evm.model.AC_000162.1.1089 Q3ZCK1 EIF3L_BOVIN 100.000 0.99646 1.00177 EIF3L - Eukaryotic translation initiation factor 3 subunit L - Bos taurus (Bovine) - EIF3L gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Taurus_UMD|evm.model.AC_000162.1.1091 E1BBG2 MILK1_BOVIN 99.883 0.997661 1.00234 MICALL1 - MICAL-like protein 1 - Bos taurus (Bovine) - MICALL1 gene Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth (By similarity). Taurus_UMD|evm.model.AC_000162.1.1092 Q9BZE7 EVG1_HUMAN 84.332 0.911392 1.09217 C22orf23 - UPF0193 protein EVG1 - Homo sapiens (Human) - C22orf23 gene Taurus_UMD|evm.model.AC_000162.1.1093 Q5R592 RPAB2_PONAB 100.000 0.984375 1.00787 POLR2F - DNA-directed RNA polymerases I, II, and III subunit RPABC2 - Pongo abelii (Sumatran orangutan) - POLR2F gene DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity). Taurus_UMD|evm.model.AC_000162.1.1094 A5A763 SOX10_PIG 99.147 0.995745 1.00213 SOX10 - Transcription factor SOX-10 - Sus scrofa (Pig) - SOX10 gene Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). Taurus_UMD|evm.model.AC_000162.1.1095 Q2T9M1 PICK1_BOVIN 99.281 0.995215 1.0024 PICK1 - PRKCA-binding protein - Bos taurus (Bovine) - PICK1 gene Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function (By similarity). Taurus_UMD|evm.model.AC_000162.1.1096 O95907 MOT3_HUMAN 86.774 0.991968 0.988095 SLC16A8 - Monocarboxylate transporter 3 - Homo sapiens (Human) - SLC16A8 gene Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). Taurus_UMD|evm.model.AC_000162.1.1097 E1BFE9 BI2L2_BOVIN 99.434 0.996219 1 BAIAP2L2 - Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 - Bos taurus (Bovine) - BAIAP2L2 gene Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). Taurus_UMD|evm.model.AC_000162.1.1098 P97819 PLPL9_MOUSE 88.724 0.949233 1.04957 Pla2g6 - 85/88 kDa calcium-independent phospholipase A2 - Mus musculus (Mouse) - Pla2g6 gene Calcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity respectively), producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:18937505). Hydrolyzes both saturated and unsaturated long fatty acyl chains in various glycerophospholipid classes such as phosphatidylcholines, phosphatidylethanolamines and phosphatidates, with a preference for hydrolysis at sn-2 position. Can further hydrolyze lysophospholipids carrying saturated fatty acyl chains (lysophospholipase activity). Upon oxidative stress, contributes to remodeling of mitochondrial phospholipids in pancreatic beta cells, in a repair mechanism to reduce oxidized lipid content (By similarity). Preferentially hydrolyzes oxidized polyunsaturated fatty acyl chains from cardiolipins, yielding monolysocardiolipins that can be reacylated with unoxidized fatty acyls to regenerate native cardiolipin species. Hydrolyzes oxidized glycerophosphoethanolamines present in pancreatic islets, releasing oxidized polyunsaturated fatty acids such as hydroxyeicosatetraenoates (HETEs) (PubMed:24648512). Has thioesterase activity toward fatty-acyl CoA releasing CoA-SH known to facilitate fatty acid transport and beta-oxidation in mitochondria particularly in skeletal muscle (PubMed:18937505). Plays a role in regulation of membrane dynamics and homeostasis. Selectively hydrolyzes sn-2 arachidonoyl group in plasmalogen phospholipids, structural components of lipid rafts and myelin (By similarity). Regulates F-actin polymerization at the pseudopods, which is required for both speed and directionality of MCP1/CCL2-induced monocyte chemotaxis (By similarity). Targets membrane phospholipids to produce potent lipid signaling messengers. Generates lysophosphatidate (LPA, 1-acyl-glycerol-3-phosphate), which acts via G-protein receptors in various cell types. Has phospholipase A2 activity toward platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), likely playing a role in inactivation of this potent proinflammatory signaling lipid (By similarity). In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion (PubMed:17895289). Taurus_UMD|evm.model.AC_000162.1.1099 A7YY73 MAFF_BOVIN 100.000 0.988439 1.00581 MAFF - Transcription factor MafF - Bos taurus (Bovine) - MAFF gene Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Taurus_UMD|evm.model.AC_000162.1.1100 A2VDL9 T184B_BOVIN 100.000 0.995098 1.00246 TMEM184B - Transmembrane protein 184B - Bos taurus (Bovine) - TMEM184B gene May activate the MAP kinase signaling pathway. Taurus_UMD|evm.model.AC_000162.1.1101 P49674 KC1E_HUMAN 98.592 0.990654 0.514423 CSNK1E - Casein kinase I isoform epsilon - Homo sapiens (Human) - CSNK1E gene Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. Taurus_UMD|evm.model.AC_000162.1.1102 Q9JMK2 KC1E_MOUSE 100.000 0.903382 0.497596 Csnk1e - Casein kinase I isoform epsilon - Mus musculus (Mouse) - Csnk1e gene Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. Taurus_UMD|evm.model.AC_000162.1.1103 P48050 KCNJ4_HUMAN 100.000 0.532051 0.350562 KCNJ4 - Inward rectifier potassium channel 4 - Homo sapiens (Human) - KCNJ4 gene Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). Taurus_UMD|evm.model.AC_000162.1.1104 O43731 ERD23_HUMAN 98.598 0.990698 1.00467 KDELR3 - ER lumen protein-retaining receptor 3 - Homo sapiens (Human) - KDELR3 gene Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. Taurus_UMD|evm.model.AC_000162.1.1105 Q92841 DDX17_HUMAN 99.387 0.996937 0.895748 DDX17 - Probable ATP-dependent RNA helicase DDX17 - Homo sapiens (Human) - DDX17 gene As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed:26209609, PubMed:22266867). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:20663877, PubMed:19995069). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:24275493, PubMed:20406972, PubMed:20663877, PubMed:19995069). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637). Taurus_UMD|evm.model.AC_000162.1.1106 Q14565 DMC1_HUMAN 92.614 0.994318 1.03529 DMC1 - Meiotic recombination protein DMC1/LIM15 homolog - Homo sapiens (Human) - DMC1 gene Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Taurus_UMD|evm.model.AC_000162.1.1107 F5H4B4 F227A_HUMAN 64.738 0.925424 1.03509 FAM227A - Protein FAM227A - Homo sapiens (Human) - FAM227A gene Taurus_UMD|evm.model.AC_000162.1.1109 Q8MJK1 CBY1_BOVIN 100.000 0.984375 1.00787 CBY1 - Protein chibby homolog 1 - Bos taurus (Bovine) - CBY1 gene Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Taurus_UMD|evm.model.AC_000162.1.1110 A6QPI6 TOM22_BOVIN 100.000 0.985816 1.00714 TOMM22 - Mitochondrial import receptor subunit TOM22 homolog - Bos taurus (Bovine) - TOMM22 gene Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity). Taurus_UMD|evm.model.AC_000162.1.1111 Q5EAE5 JOS1_BOVIN 100.000 0.990148 1.00495 JOSD1 - Josephin-1 - Bos taurus (Bovine) - JOSD1 gene Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity). Taurus_UMD|evm.model.AC_000162.1.1112 Q58DC5 GTPB1_BOVIN 100.000 0.997015 1.00149 GTPBP1 - GTP-binding protein 1 - Bos taurus (Bovine) - GTPBP1 gene Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). Taurus_UMD|evm.model.AC_000162.1.1113 Q9UH99 SUN2_HUMAN 83.379 0.997253 1.01534 SUN2 - SUN domain-containing protein 2 - Homo sapiens (Human) - SUN2 gene As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. Taurus_UMD|evm.model.AC_000162.1.1114 A4F4L4 DNAL4_PIG 98.113 0.448276 1.10476 DNAL4 - Dynein axonemal light chain 4 - Sus scrofa (Pig) - DNAL4 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity). Taurus_UMD|evm.model.AC_000162.1.1115 O95502 NPTXR_HUMAN 93.643 0.973558 0.832 NPTXR - Neuronal pentraxin receptor - Homo sapiens (Human) - NPTXR gene May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. Taurus_UMD|evm.model.AC_000162.1.1116 O95503 CBX6_HUMAN 90.633 0.834746 1.14563 CBX6 - Chromobox protein homolog 6 - Homo sapiens (Human) - CBX6 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). Taurus_UMD|evm.model.AC_000162.1.1117 Q694B9 ABC3G_SAGLB 51.562 0.245308 1.95801 APOBEC3G - DNA dC->dU-editing enzyme APOBEC-3G - Saguinus labiatus (Red-chested mustached tamarin) - APOBEC3G gene DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA (By similarity). Taurus_UMD|evm.model.AC_000162.1.1118 O95931 CBX7_HUMAN 95.618 0.992063 1.00398 CBX7 - Chromobox protein homolog 7 - Homo sapiens (Human) - CBX7 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. Taurus_UMD|evm.model.AC_000162.1.1119 Q95229 PDGFB_SHEEP 97.521 0.991736 1.00415 PDGFB - Platelet-derived growth factor subunit B precursor - Ovis aries (Sheep) - PDGFB gene Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). Taurus_UMD|evm.model.AC_000162.1.1120 P39872 RL3_BOVIN 100.000 0.99505 1.00248 RPL3 - 60S ribosomal protein L3 - Bos taurus (Bovine) - RPL3 gene The L3 protein is a component of the large subunit of cytoplasmic ribosomes. Taurus_UMD|evm.model.AC_000162.1.1122 Q62876 SNG1_RAT 93.590 0.991489 1.00427 Syngr1 - Synaptogyrin-1 - Rattus norvegicus (Rat) - Syngr1 gene May play a role in regulated exocytosis (PubMed:10383386). Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (PubMed:15590695, PubMed:12928441). Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). Taurus_UMD|evm.model.AC_000162.1.1123 Q15750 TAB1_HUMAN 97.421 0.99604 1.00198 TAB1 - TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 - Homo sapiens (Human) - TAB1 gene May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Taurus_UMD|evm.model.AC_000162.1.1124 Q09327 MGAT3_HUMAN 93.645 0.994413 1.0075 MGAT3 - Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase - Homo sapiens (Human) - MGAT3 gene It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition, but also the conformation of the N-glycan. The introduction of the bisecting GlcNAc residue results in the suppression of further processing and elongation of N-glycans, precluding the formation of beta-1,6 GlcNAc branching, catalyzed by MGAT5 since it is unable to use the bisected oligosaccharide as a substrate (PubMed:19403558). Addition of bisecting N-acetylglucosamine to CDH1/E-cadherin modulates CDH1 cell membrane location (PubMed:19403558). Inhibits NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc- formation which modulates sialylation levels and plays a role in cell migration regulation (PubMed:26801611). In brain, addition of bisecting N-acetylglucosamine to BACE1 blocks its lysosomal targeting in response to oxidative stress and further degradation which increases its location to early endosome and the APP cleavage (By similarity). Taurus_UMD|evm.model.AC_000162.1.1125 L0R8F8 MIDUO_HUMAN 90.000 0.71875 1.37143 MIEF1 - MIEF1 upstream open reading frame protein - Homo sapiens (Human) - MIEF1 gene Involved in the regulation of mitochondrial fission mediated by DNM1L (PubMed:29083303). Positively regulates mitochondrial translation (PubMed:30215512). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Taurus_UMD|evm.model.AC_000162.1.1126 Q8BGV8 MID51_MOUSE 96.760 0.99569 1.00216 Mief1 - Mitochondrial dynamics protein MID51 - Mus musculus (Mouse) - Mief1 gene Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. Taurus_UMD|evm.model.AC_000162.1.1127 Q3ZCH6 ATF4_BOVIN 99.713 0.994269 1.00287 ATF4 - Cyclic AMP-dependent transcription factor ATF-4 - Bos taurus (Bovine) - ATF4 gene Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR) (By similarity). Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (By similarity). Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress. During ISR, ATF4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced ATF4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (By similarity). Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (By similarity). Activates the transcription of NLRP1, possibly in concert with other factors in response to ER stress. Activates the transcription of asparagine synthetase (ASNS) in response to amino acid deprivation or ER stress. However, when associated with DDIT3/CHOP, the transcriptional activation of the ASNS gene is inhibited in response to amino acid deprivation (By similarity). Together with DDIT3/CHOP, mediates programmed cell death by promoting the expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the terminal unfolded protein response (terminal UPR), a cellular response that elicits programmed cell death when ER stress is prolonged and unresolved (By similarity). Together with DDIT3/CHOP, activates the transcription of the IRS-regulator TRIB3 and promotes ER stress-induced neuronal cell death by regulating the expression of BBC3/PUMA in response to ER stress. May cooperate with the UPR transcriptional regulator QRICH1 to regulate ER protein homeostasis which is critical for cell viability in response to ER stress (By similarity). In the absence of stress, ATF4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (By similarity). Acts as a regulator of osteoblast differentiation in response to phosphorylation by RPS6KA3/RSK2: phosphorylation in osteoblasts enhances transactivation activity and promotes expression of osteoblast-specific genes and post-transcriptionally regulates the synthesis of Type I collagen, the main constituent of the bone matrix (By similarity). Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor: acts as a regulator of synaptic plasticity by repressing transcription, thereby inhibiting induction and maintenance of long-term memory (By similarity). Regulates synaptic functions via interaction with DISC1 in neurons, which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (By similarity). Taurus_UMD|evm.model.AC_000162.1.1128 A6H7J2 AROS_BOVIN 100.000 0.985507 1.0073 RPS19BP1 - Active regulator of SIRT1 - Bos taurus (Bovine) - RPS19BP1 gene Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (By similarity). Taurus_UMD|evm.model.AC_000162.1.1129 Q9P0X4 CAC1I_HUMAN 91.838 0.915108 0.937922 CACNA1I - Voltage-dependent T-type calcium channel subunit alpha-1I - Homo sapiens (Human) - CACNA1I gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity). Taurus_UMD|evm.model.AC_000162.1.1130 Q8IYW4 ENTD1_HUMAN 69.394 0.996727 1.00659 ENTHD1 - ENTH domain-containing protein 1 - Homo sapiens (Human) - ENTHD1 gene clathrin vesicle coat, endosome, intracellular membrane-bounded organelle, plasma membrane, clathrin binding, phospholipid binding, endocytosis Taurus_UMD|evm.model.AC_000162.1.1131 O75791 GRAP2_HUMAN 82.121 0.993691 0.960606 GRAP2 - GRB2-related adapter protein 2 - Homo sapiens (Human) - GRAP2 gene Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. Taurus_UMD|evm.model.AC_000162.1.1132 Q8NEG4 FA83F_HUMAN 71.709 0.995585 0.906 FAM83F - Protein FAM83F - Homo sapiens (Human) - FAM83F gene protein kinase binding, signal transduction Taurus_UMD|evm.model.AC_000162.1.1133 Q8BKI2 TNR6B_MOUSE 93.729 0.957256 1.04696 Tnrc6b - Trinucleotide repeat-containing gene 6B protein - Mus musculus (Mouse) - Tnrc6b gene Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Taurus_UMD|evm.model.AC_000162.1.1134 A3KN12 PUR8_BOVIN 99.592 0.995927 1.00204 ADSL - Adenylosuccinate lyase - Bos taurus (Bovine) - ADSL gene Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. Taurus_UMD|evm.model.AC_000162.1.1135 Q2KI13 SGSM3_BOVIN 100.000 0.997326 1.00134 SGSM3 - Small G protein signaling modulator 3 - Bos taurus (Bovine) - SGSM3 gene May play a cooperative role in NF2-mediated growth suppression of cells. Taurus_UMD|evm.model.AC_000162.1.1136 Q8K4J6 MRTFA_MOUSE 81.138 0.535395 1.2749 Mrtfa - Myocardin-related transcription factor A - Mus musculus (Mouse) - Mrtfa gene Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12019265, PubMed:12732141, PubMed:17588931, PubMed:19350017, PubMed:24732378). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378). MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex (PubMed:12732141, PubMed:17588931). Activity is also regulated by filamentous actin (F-actin) in the nucleus (PubMed:23558171, PubMed:25759381). Taurus_UMD|evm.model.AC_000162.1.1137 Q9MZ01 MCHR1_PIG 98.347 0.338983 2.92562 MCHR1 - Melanin-concentrating hormone receptor 1 - Sus scrofa (Pig) - MCHR1 gene Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. Taurus_UMD|evm.model.AC_000162.1.1138 O43808 PM34_HUMAN 94.463 0.993506 1.00326 SLC25A17 - Peroxisomal membrane protein PMP34 - Homo sapiens (Human) - SLC25A17 gene Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro. Taurus_UMD|evm.model.AC_000162.1.1139 P50502 F10A1_HUMAN 95.122 0.994595 1.00271 ST13 - Hsc70-interacting protein - Homo sapiens (Human) - ST13 gene One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). Taurus_UMD|evm.model.AC_000162.1.1140 Q5R9W8 XPP3_PONAB 89.941 0.996063 1.00197 XPNPEP3 - Xaa-Pro aminopeptidase 3 precursor - Pongo abelii (Sumatran orangutan) - XPNPEP3 gene Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position. Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling. Taurus_UMD|evm.model.AC_000162.1.1141 P62878 RBX1_MOUSE 100.000 0.981651 1.00926 Rbx1 - E3 ubiquitin-protein ligase RBX1 - Mus musculus (Mouse) - Rbx1 gene E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:22118460). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components (By similarity). As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate (By similarity). Probably also stimulates CDC34 autoubiquitination (By similarity). May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair (By similarity). Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M (By similarity). Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (By similarity). In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM (By similarity). Taurus_UMD|evm.model.AC_000162.1.1143 Q09472 EP300_HUMAN 94.382 0.999171 0.999171 EP300 - Histone acetyltransferase p300 - Homo sapiens (Human) - EP300 gene Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1 or SIRT2 (PubMed:12929931, PubMed:16762839, PubMed:18722353). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degragation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Taurus_UMD|evm.model.AC_000162.1.1144 Q1JQD9 LMBL2_BOVIN 100.000 0.997171 1.00142 L3MBTL2 - Lethal(3)malignant brain tumor-like protein 2 - Bos taurus (Bovine) - L3MBTL2 gene Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity). Taurus_UMD|evm.model.AC_000162.1.1145 Q6NUI6 CHADL_HUMAN 76.552 0.934566 0.922572 CHADL - Chondroadherin-like protein precursor - Homo sapiens (Human) - CHADL gene Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment. Taurus_UMD|evm.model.AC_000162.1.1146 P46060 RAGP1_HUMAN 90.801 0.931419 1.06814 RANGAP1 - Ran GTPase-activating protein 1 - Homo sapiens (Human) - RANGAP1 gene GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). Taurus_UMD|evm.model.AC_000162.1.1147 Q9UGR2 Z3H7B_HUMAN 96.559 0.940137 1.04299 ZC3H7B - Zinc finger CCCH domain-containing protein 7B - Homo sapiens (Human) - ZC3H7B gene May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apical loop. Taurus_UMD|evm.model.AC_000162.1.1148 P97516 TEF_PHOSU 98.190 0.722772 1.37104 TEF - Thyrotroph embryonic factor - Phodopus sungorus (Striped hairy-footed hamster) - TEF gene Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3' (By similarity). Taurus_UMD|evm.model.AC_000162.1.1149 Q14106 TOB2_HUMAN 94.493 0.99422 1.00581 TOB2 - Protein Tob2 - Homo sapiens (Human) - TOB2 gene Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases. Taurus_UMD|evm.model.AC_000162.1.1150 P83871 PHF5A_RAT 100.000 0.981982 1.00909 Phf5a - PHD finger-like domain-containing protein 5A - Rattus norvegicus (Rat) - Phf5a gene Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes. Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies. Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (By similarity). Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity). Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha (PubMed:12810571). Taurus_UMD|evm.model.AC_000162.1.1151 P20004 ACON_BOVIN 100.000 0.997439 1.00128 ACO2 - Aconitate hydratase, mitochondrial precursor - Bos taurus (Bovine) - ACO2 gene Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. Taurus_UMD|evm.model.AC_000162.1.1152 Q2T9X1 RPC8_BOVIN 99.020 0.990244 1.0049 POLR3H - DNA-directed RNA polymerase III subunit RPC8 - Bos taurus (Bovine) - POLR3H gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNA. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Taurus_UMD|evm.model.AC_000162.1.1153 Q9Y534 CSDC2_HUMAN 94.771 0.610442 1.62745 CSDC2 - Cold shock domain-containing protein C2 - Homo sapiens (Human) - CSDC2 gene RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). Taurus_UMD|evm.model.AC_000162.1.1154 Q92871 PMM1_HUMAN 96.183 0.992395 1.00382 PMM1 - Phosphomannomutase 1 - Homo sapiens (Human) - PMM1 gene Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. Taurus_UMD|evm.model.AC_000162.1.1155 O02751 CFDP2_BOVIN 76.111 0.972678 0.309122 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000162.1.1156 Q6ICB0 DESI1_HUMAN 95.238 0.988166 1.00595 DESI1 - Desumoylating isopeptidase 1 - Homo sapiens (Human) - DESI1 gene Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Taurus_UMD|evm.model.AC_000162.1.1157 P12956 XRCC6_HUMAN 84.375 0.993421 0.998358 XRCC6 - X-ray repair cross-complementing protein 6 - Homo sapiens (Human) - XRCC6 gene Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Taurus_UMD|evm.model.AC_000162.1.1158 P55770 NH2L1_RAT 100.000 0.984496 1.00781 Snu13 - NHP2-like protein 1 - Rattus norvegicus (Rat) - Snu13 gene Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. Taurus_UMD|evm.model.AC_000162.1.1159 C9J442 CV046_HUMAN 64.372 0.15409 6.48971 C22orf46 - Uncharacterized protein C22orf46 precursor - Homo sapiens (Human) - C22orf46 gene Taurus_UMD|evm.model.AC_000162.1.1160 A8D8X1 RL10_SHEEP 99.038 0.0769806 6.25234 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000162.1.1161 Q9H6E4 CC134_HUMAN 93.458 0.926087 1.00437 CCDC134 - Coiled-coil domain-containing protein 134 precursor - Homo sapiens (Human) - CCDC134 gene In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808). Taurus_UMD|evm.model.AC_000162.1.1162 Q12772 SRBP2_HUMAN 91.097 0.939086 1.03593 SREBF2 - Sterol regulatory element-binding protein 2 - Homo sapiens (Human) - SREBF2 gene Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). Taurus_UMD|evm.model.AC_000162.1.1163 J3QNX5 SHSA8_MOUSE 75.893 0.822878 0.679198 Shisa8 - Protein shisa-8 precursor - Mus musculus (Mouse) - Shisa8 gene May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses. Taurus_UMD|evm.model.AC_000162.1.1164 Q96RJ3 TR13C_HUMAN 63.415 0.493902 0.891304 TNFRSF13C - Tumor necrosis factor receptor superfamily member 13C - Homo sapiens (Human) - TNFRSF13C gene B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. Taurus_UMD|evm.model.AC_000162.1.1165 Q2TBH1 CENPM_BOVIN 100.000 0.98895 1.00556 CENPM - Centromere protein M - Bos taurus (Bovine) - CENPM gene Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Taurus_UMD|evm.model.AC_000162.1.1167 Q08DM7 SEPT3_BOVIN 99.440 0.440049 2.26611 SEPTIN3 - Neuronal-specific septin-3 - Bos taurus (Bovine) - SEPTIN3 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Taurus_UMD|evm.model.AC_000162.1.1168 A3KFF6 WBP2L_BOVIN 100.000 0.993631 1.00319 WBP2NL - Postacrosomal sheath WW domain-binding protein - Bos taurus (Bovine) - WBP2NL gene May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization. Taurus_UMD|evm.model.AC_000162.1.1169 Q58DH9 NAGAB_BOVIN 99.757 0.995146 1.00243 NAGA - Alpha-N-acetylgalactosaminidase precursor - Bos taurus (Bovine) - NAGA gene Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids. Taurus_UMD|evm.model.AC_000162.1.1170 Q1RMU7 SESQ2_BOVIN 100.000 0.980989 1.01544 PHETA2 - Sesquipedalian-2 - Bos taurus (Bovine) - PHETA2 gene Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. Taurus_UMD|evm.model.AC_000162.1.1171 Q2M2S2 EMRE_BOVIN 100.000 0.981481 1.00935 SMDT1 - Essential MCU regulator, mitochondrial precursor - Bos taurus (Bovine) - SMDT1 gene Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU. Plays a central role in regulating the uniplex complex response to intracellular calcium signaling. Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling. Taurus_UMD|evm.model.AC_000162.1.1172 Q02366 NDUA6_BOVIN 100.000 0.819355 1.21094 NDUFA6 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 - Bos taurus (Bovine) - NDUFA6 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000162.1.1174 Q01361 CP2DE_BOVIN 96.296 0.180438 1.186 CYP2D14 - Cytochrome P450 2D14 - Bos taurus (Bovine) - CYP2D14 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Taurus_UMD|evm.model.AC_000162.1.1176 Q01361 CP2DE_BOVIN 98.800 0.996008 1.002 CYP2D14 - Cytochrome P450 2D14 - Bos taurus (Bovine) - CYP2D14 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Taurus_UMD|evm.model.AC_000162.1.1178 Q9UGU0 TCF20_HUMAN 91.832 0.976179 1.02806 TCF20 - Transcription factor 20 - Homo sapiens (Human) - TCF20 gene Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. Taurus_UMD|evm.model.AC_000162.1.1179 Q8NET5 NFAM1_HUMAN 63.801 0.655689 1.23704 NFAM1 - NFAT activation molecule 1 precursor - Homo sapiens (Human) - NFAM1 gene May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking. Taurus_UMD|evm.model.AC_000162.1.1180 Q9NQF3 SERHL_HUMAN 80.117 0.433673 1.93103 SERHL - Serine hydrolase-like protein - Homo sapiens (Human) - SERHL gene Putative serine hydrolase. Taurus_UMD|evm.model.AC_000162.1.1181 Q9NSQ0 RRP7B_HUMAN 91.346 0.366548 2.72816 RRP7BP - Putative ribosomal RNA-processing protein 7 homolog B - Homo sapiens (Human) - RRP7BP gene CURI complex, UTP-C complex, ribosomal small subunit assembly, rRNA processing Taurus_UMD|evm.model.AC_000162.1.1182 Q9BY77 PDIP3_HUMAN 94.774 0.995261 1.00238 POLDIP3 - Polymerase delta-interacting protein 3 - Homo sapiens (Human) - POLDIP3 gene Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. Taurus_UMD|evm.model.AC_000162.1.1183 P07514 NB5R3_BOVIN 100.000 0.992832 0.92691 CYB5R3 - NADH-cytochrome b5 reductase 3 - Bos taurus (Bovine) - CYB5R3 gene Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Taurus_UMD|evm.model.AC_000162.1.1184 Q9N289 A4GAT_PONPY 90.826 0.609551 1.63303 A4GALT - Lactosylceramide 4-alpha-galactosyltransferase - Pongo pygmaeus (Bornean orangutan) - A4GALT gene Catalyzes the transfer of galactose from UDP-alpha-D-galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1 Taurus_UMD|evm.model.AC_000162.1.1185 P24049 RL17_RAT 92.121 0.863158 1.03261 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000162.1.1186 Q17R07 ARFG3_BOVIN 100.000 0.996139 1.00193 ARFGAP3 - ADP-ribosylation factor GTPase-activating protein 3 - Bos taurus (Bovine) - ARFGAP3 gene GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1) (PubMed:1910037). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity). Taurus_UMD|evm.model.AC_000162.1.1187 Q5RDT5 SAP18_PONAB 89.542 0.986928 1 SAP18 - Histone deacetylase complex subunit SAP18 - Pongo abelii (Sumatran orangutan) - SAP18 gene Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function (By similarity). Taurus_UMD|evm.model.AC_000162.1.1188 Q9WVE8 PACN2_MOUSE 91.152 0.995893 1.00206 Pacsin2 - Protein kinase C and casein kinase substrate in neurons protein 2 - Mus musculus (Mouse) - Pacsin2 gene Regulates the morphogenesis and endocytosis of caveolae (PubMed:21807942). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. Taurus_UMD|evm.model.AC_000162.1.1189 Q0VC71 TTLL1_BOVIN 100.000 0.95672 1.03783 TTLL1 - Probable tubulin polyglutamylase TTLL1 - Bos taurus (Bovine) - TTLL1 gene Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity). Taurus_UMD|evm.model.AC_000162.1.1190 Q13323 BIK_HUMAN 34.400 0.730769 0.975 BIK - Bcl-2-interacting killer - Homo sapiens (Human) - BIK gene Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. Taurus_UMD|evm.model.AC_000162.1.1191 Q8IVS2 FABD_HUMAN 80.357 0.992268 0.994872 MCAT - Malonyl-CoA-acyl carrier protein transacylase, mitochondrial precursor - Homo sapiens (Human) - MCAT gene Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria. Taurus_UMD|evm.model.AC_000162.1.1192 P30535 TSPO_BOVIN 98.817 0.988235 1.00592 TSPO - Translocator protein - Bos taurus (Bovine) - TSPO gene Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1649835). Taurus_UMD|evm.model.AC_000162.1.1193 Q14166 TTL12_HUMAN 85.191 0.996951 1.01863 TTLL12 - Tubulin--tyrosine ligase-like protein 12 - Homo sapiens (Human) - TTLL12 gene Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935). Taurus_UMD|evm.model.AC_000162.1.1194 Q6NZL8 SCUB1_MOUSE 90.063 0.939036 0.999018 Scube1 - Signal peptide, CUB and EGF-like domain-containing protein 1 precursor - Mus musculus (Mouse) - Scube1 gene Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. Taurus_UMD|evm.model.AC_000162.1.1195 O15442 MPPD1_HUMAN 98.578 0.990566 0.650307 MPPED1 - Metallophosphoesterase domain-containing protein 1 - Homo sapiens (Human) - MPPED1 gene May have metallophosphoesterase activity (in vitro). Taurus_UMD|evm.model.AC_000162.1.1196 Q2HJ55 SAM50_BOVIN 93.933 0.995825 1.02132 SAMM50 - Sorting and assembly machinery component 50 homolog - Bos taurus (Bovine) - SAMM50 gene Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex. Taurus_UMD|evm.model.AC_000162.1.1197 Q9NST1 PLPL3_HUMAN 55.990 0.808791 0.945946 PNPLA3 - 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 - Homo sapiens (Human) - PNPLA3 gene Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (PubMed:15364929, PubMed:20034933, PubMed:22560221). Has hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety (PubMed:21878620). Taurus_UMD|evm.model.AC_000162.1.1199 Q9NST1 PLPL3_HUMAN 55.556 0.884701 0.93763 PNPLA3 - 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 - Homo sapiens (Human) - PNPLA3 gene Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (PubMed:15364929, PubMed:20034933, PubMed:22560221). Has hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety (PubMed:21878620). Taurus_UMD|evm.model.AC_000162.1.1200 Q7Z6Z6 PLPL5_HUMAN 64.624 0.993976 0.773893 PNPLA5 - Patatin-like phospholipase domain-containing protein 5 - Homo sapiens (Human) - PNPLA5 gene Has abundant triacylglycerol lipase activity. Taurus_UMD|evm.model.AC_000162.1.1201 Q9BR01 ST4A1_HUMAN 99.296 0.992982 1.00352 SULT4A1 - Sulfotransferase 4A1 - Homo sapiens (Human) - SULT4A1 gene Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS. Taurus_UMD|evm.model.AC_000162.1.1202 Q4R8T1 EFCB6_MACFA 77.709 0.475204 2.09133 EFCAB6 - EF-hand calcium-binding domain-containing protein 6 - Macaca fascicularis (Crab-eating macaque) - EFCAB6 gene Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex. Taurus_UMD|evm.model.AC_000162.1.1203 Q5REB1 MPPD2_PONAB 84.000 0.621849 0.404762 MPPED2 - Metallophosphoesterase MPPED2 - Pongo abelii (Sumatran orangutan) - MPPED2 gene Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system. Taurus_UMD|evm.model.AC_000162.1.1204 Q9HBI1 PARVB_HUMAN 91.437 0.953216 0.93956 PARVB - Beta-parvin - Homo sapiens (Human) - PARVB gene Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. Taurus_UMD|evm.model.AC_000162.1.1205 Q9HBI0 PARVG_HUMAN 81.873 0.962099 1.03625 PARVG - Gamma-parvin - Homo sapiens (Human) - PARVG gene Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Taurus_UMD|evm.model.AC_000162.1.1206 Q3SXP7 SHSL1_HUMAN 94.975 0.985 1.00503 SHISAL1 - Protein shisa-like-1 precursor - Homo sapiens (Human) - SHISAL1 gene Taurus_UMD|evm.model.AC_000162.1.1207 Q6ICC9 RTL6_HUMAN 94.142 0.991667 1.00418 RTL6 - Retrotransposon Gag-like protein 6 - Homo sapiens (Human) - RTL6 gene Taurus_UMD|evm.model.AC_000162.1.1209 P85299 PRR5_HUMAN 87.724 0.994898 1.01031 PRR5 - Proline-rich protein 5 - Homo sapiens (Human) - PRR5 gene Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. Taurus_UMD|evm.model.AC_000162.1.1210 Q9CXP4 RHG08_MOUSE 79.759 0.8625 1.12941 Arhgap8 - Rho GTPase-activating protein 8 - Mus musculus (Mouse) - Arhgap8 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000162.1.1211 Q8C966 PF21B_MOUSE 81.953 0.606727 1.58727 Phf21b - PHD finger protein 21B - Mus musculus (Mouse) - Phf21b gene Taurus_UMD|evm.model.AC_000162.1.1212 Q96EK2 PF21B_HUMAN 100.000 0.226744 0.323917 PHF21B - PHD finger protein 21B - Homo sapiens (Human) - PHF21B gene Taurus_UMD|evm.model.AC_000162.1.1215 Q9UKX7 NUP50_HUMAN 84.681 0.995708 0.995726 NUP50 - Nuclear pore complex protein Nup50 - Homo sapiens (Human) - NUP50 gene Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). Taurus_UMD|evm.model.AC_000162.1.1216 Q6ICG6 K0930_HUMAN 94.724 0.9274 1.05693 KIAA0930 - Uncharacterized protein KIAA0930 - Homo sapiens (Human) - KIAA0930 gene Taurus_UMD|evm.model.AC_000162.1.1217 P38574 UPK3A_BOVIN 100.000 0.993056 1.00348 UPK3A - Uroplakin-3a precursor - Bos taurus (Bovine) - UPK3A gene Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence. Taurus_UMD|evm.model.AC_000162.1.1218 Q91YN1 F118A_MOUSE 93.838 0.994413 1.0028 Fam118a - Protein FAM118A - Mus musculus (Mouse) - Fam118a gene identical protein binding Taurus_UMD|evm.model.AC_000162.1.1219 Q8NDV3 SMC1B_HUMAN 88.618 0.994337 1.00081 SMC1B - Structural maintenance of chromosomes protein 1B - Homo sapiens (Human) - SMC1B gene Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity). Taurus_UMD|evm.model.AC_000162.1.1220 Q32LJ7 RIBC2_BOVIN 100.000 0.994709 1.00265 RIBC2 - RIB43A-like with coiled-coils protein 2 - Bos taurus (Bovine) - RIBC2 gene Taurus_UMD|evm.model.AC_000162.1.1221 Q8MJJ9 FBLN1_CHLAE 88.060 0.874818 1.14883 FBLN1 - Fibulin-1 - Chlorocebus aethiops (Green monkey) - FBLN1 gene Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. May serve to anchor the mature/soluble form of DTR to its fibers as it migrates through the extracellular matrix. The direct physical association with DTR may be useful in such tissue developmental processes as wound healing. Taurus_UMD|evm.model.AC_000162.1.1222 P23142 FBLN1_HUMAN 88.435 0.954248 0.217639 FBLN1 - Fibulin-1 precursor - Homo sapiens (Human) - FBLN1 gene Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. Taurus_UMD|evm.model.AC_000162.1.1224 Q2TBW0 ATX10_BOVIN 99.789 0.855596 1.16632 ATXN10 - Ataxin-10 - Bos taurus (Bovine) - ATXN10 gene Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. Taurus_UMD|evm.model.AC_000162.1.1225 P28047 WNT7B_MOUSE 98.800 0.968872 0.73639 Wnt7b - Protein Wnt-7b precursor - Mus musculus (Mouse) - Wnt7b gene Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619, PubMed:28803732). Required for normal fusion of the chorion and the allantois during placenta development (PubMed:11543617). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:28803732). Taurus_UMD|evm.model.AC_000162.1.1226 P56706 WNT7B_HUMAN 96.154 0.534722 0.412607 WNT7B - Protein Wnt-7b precursor - Homo sapiens (Human) - WNT7B gene Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:30026314). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Taurus_UMD|evm.model.AC_000162.1.1228 Q95N78 PPARA_CANLF 95.299 0.63365 1.57479 PPARA - Peroxisome proliferator-activated receptor alpha - Canis lupus familiaris (Dog) - PPARA gene Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity). Taurus_UMD|evm.model.AC_000162.1.1229 Q0VCH3 CDPF1_BOVIN 100.000 0.774194 1.28099 CDPF1 - Cysteine-rich DPF motif domain-containing protein 1 - Bos taurus (Bovine) - CDPF1 gene Taurus_UMD|evm.model.AC_000162.1.1230 Q9NTG1 PKDRE_HUMAN 66.237 0.99857 0.62095 PKDREJ - Polycystic kidney disease and receptor for egg jelly-related protein precursor - Homo sapiens (Human) - PKDREJ gene May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm. Taurus_UMD|evm.model.AC_000162.1.1231 Q5RFF7 TTC38_PONAB 83.156 0.995671 0.985075 TTC38 - Tetratricopeptide repeat protein 38 - Pongo abelii (Sumatran orangutan) - TTC38 gene Taurus_UMD|evm.model.AC_000162.1.1232 Q9NYZ3 GTSE1_HUMAN 66.509 0.619469 0.470833 GTSE1 - G2 and S phase-expressed protein 1 - Homo sapiens (Human) - GTSE1 gene May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression. Taurus_UMD|evm.model.AC_000162.1.1233 Q9NTG1 PKDRE_HUMAN 62.638 0.972007 1.03063 PKDREJ - Polycystic kidney disease and receptor for egg jelly-related protein precursor - Homo sapiens (Human) - PKDREJ gene May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm. Taurus_UMD|evm.model.AC_000162.1.1234 Q9NTG1 PKDRE_HUMAN 67.835 0.99844 0.569019 PKDREJ - Polycystic kidney disease and receptor for egg jelly-related protein precursor - Homo sapiens (Human) - PKDREJ gene May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm. Taurus_UMD|evm.model.AC_000162.1.1235 Q9NTG1 PKDRE_HUMAN 57.763 0.986962 0.340435 PKDREJ - Polycystic kidney disease and receptor for egg jelly-related protein precursor - Homo sapiens (Human) - PKDREJ gene May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm. Taurus_UMD|evm.model.AC_000162.1.1236 Q9NYZ3 GTSE1_HUMAN 57.438 0.993763 0.668056 GTSE1 - G2 and S phase-expressed protein 1 - Homo sapiens (Human) - GTSE1 gene May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression. Taurus_UMD|evm.model.AC_000162.1.1237 O75648 MTU1_HUMAN 90.625 0.992823 0.992874 TRMU - Mitochondrial tRNA-specific 2-thiouridylase 1 - Homo sapiens (Human) - TRMU gene Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. Taurus_UMD|evm.model.AC_000162.1.1238 O35161 CELR1_MOUSE 77.790 0.997125 0.573171 Celsr1 - Cadherin EGF LAG seven-pass G-type receptor 1 precursor - Mus musculus (Mouse) - Celsr1 gene Receptor that may have an important role in cell/cell signaling during nervous system formation. Taurus_UMD|evm.model.AC_000162.1.1239 O35161 CELR1_MOUSE 95.175 0.430915 0.522413 Celsr1 - Cadherin EGF LAG seven-pass G-type receptor 1 precursor - Mus musculus (Mouse) - Celsr1 gene Receptor that may have an important role in cell/cell signaling during nervous system formation. Taurus_UMD|evm.model.AC_000162.1.1240 Q6IC98 GRAM4_HUMAN 93.253 0.953719 1.04671 GRAMD4 - GRAM domain-containing protein 4 - Homo sapiens (Human) - GRAMD4 gene Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (PubMed:15565177). Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (By similarity). Taurus_UMD|evm.model.AC_000162.1.1241 Q8TCT0 CERK1_HUMAN 72.441 0.937037 1.00559 CERK - Ceramide kinase - Homo sapiens (Human) - CERK gene Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:11956206, PubMed:16269826, PubMed:19168031). Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:11956206, PubMed:16269826, PubMed:19168031). Shows a greater preference for D-erythro isomer of ceramides (PubMed:16269826). Binds phosphoinositides (PubMed:19168031). Taurus_UMD|evm.model.AC_000162.1.1243 Q95KI1 TB22A_MACFA 85.714 0.903108 1.1006 TBC1D22A - TBC1 domain family member 22A - Macaca fascicularis (Crab-eating macaque) - TBC1D22A gene May act as a GTPase-activating protein for Rab family protein(s). Taurus_UMD|evm.model.AC_000162.1.1261 Q3ZBS2 TAFA5_BOVIN 94.949 0.942308 0.787879 TAFA5 - Chemokine-like protein TAFA-5 precursor - Bos taurus (Bovine) - TAFA5 gene Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated through the GPCR FPR2 (By similarity). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (By similarity). Taurus_UMD|evm.model.AC_000162.1.1263 Q9BVL4 SELO_HUMAN 81.735 0.964602 1.01345 SELENOO - Protein adenylyltransferase SelO, mitochondrial precursor - Homo sapiens (Human) - SELENOO gene Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation) (PubMed:30270044). May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein (PubMed:24751718). Taurus_UMD|evm.model.AC_000162.1.1264 Q96RT7 GCP6_HUMAN 73.037 0.684466 0.905992 TUBGCP6 - Gamma-tubulin complex component 6 - Homo sapiens (Human) - TUBGCP6 gene Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Taurus_UMD|evm.model.AC_000162.1.1265 Q969S8 HDA10_HUMAN 78.979 0.989568 1.00299 HDAC10 - Polyamine deacetylase HDAC10 - Homo sapiens (Human) - HDAC10 gene Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039). Taurus_UMD|evm.model.AC_000162.1.1266 P53778 MK12_HUMAN 92.916 0.994565 1.00272 MAPK12 - Mitogen-activated protein kinase 12 - Homo sapiens (Human) - MAPK12 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. Taurus_UMD|evm.model.AC_000162.1.1267 Q15759 MK11_HUMAN 96.522 0.780045 1.21154 MAPK11 - Mitogen-activated protein kinase 11 - Homo sapiens (Human) - MAPK11 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Taurus_UMD|evm.model.AC_000162.1.1268 O15031 PLXB2_HUMAN 87.195 0.950464 1.05441 PLXNB2 - Plexin-B2 precursor - Homo sapiens (Human) - PLXNB2 gene Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar granule cells in the developing brain (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12183458). Plays a role in axon guidance, invasive growth and cell migration (PubMed:15184888). May modulate the activity of RAC1 and CDC42 (By similarity). Taurus_UMD|evm.model.AC_000162.1.1269 Q8NEG7 DEN6B_HUMAN 86.724 0.984563 0.996581 DENND6B - Protein DENND6B - Homo sapiens (Human) - DENND6B gene Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35. Taurus_UMD|evm.model.AC_000162.1.1271 O75170 PP6R2_HUMAN 74.302 0.97153 0.872671 PPP6R2 - Serine/threonine-protein phosphatase 6 regulatory subunit 2 - Homo sapiens (Human) - PPP6R2 gene Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Taurus_UMD|evm.model.AC_000162.1.1272 O95248 MTMR5_HUMAN 88.235 0.95329 1.06585 SBF1 - Myotubularin-related protein 5 - Homo sapiens (Human) - SBF1 gene Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location (PubMed:12668758). May function as a guanine nucleotide exchange factor (GEF) activating RAB28 (PubMed:20937701). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701). Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts (PubMed:9537414). Taurus_UMD|evm.model.AC_000162.1.1273 Q7Z4H4 ADM2_HUMAN 68.243 0.986014 0.966216 ADM2 - Protein ADM2 precursor - Homo sapiens (Human) - ADM2 gene May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. Taurus_UMD|evm.model.AC_000162.1.1274 A7MBE4 MIOX_BOVIN 100.000 0.644068 1.03509 MIOX - Inositol oxygenase - Bos taurus (Bovine) - MIOX gene ferric iron binding, inositol oxygenase activity, inositol catabolic process Taurus_UMD|evm.model.AC_000162.1.1276 A7MBE4 MIOX_BOVIN 98.649 0.623932 0.410526 MIOX - Inositol oxygenase - Bos taurus (Bovine) - MIOX gene ferric iron binding, inositol oxygenase activity, inositol catabolic process Taurus_UMD|evm.model.AC_000162.1.1277 A1L504 LMF2_BOVIN 99.405 0.989676 0.964438 LMF2 - Lipase maturation factor 2 - Bos taurus (Bovine) - LMF2 gene Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity). Taurus_UMD|evm.model.AC_000162.1.1278 Q3SZL8 CNDH2_BOVIN 100.000 0.962171 0.977492 NCAPH2 - Condensin-2 complex subunit H2 - Bos taurus (Bovine) - NCAPH2 gene Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (By similarity). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (By similarity). Taurus_UMD|evm.model.AC_000162.1.1279 A6H784 SCO2_BOVIN 100.000 0.923345 1.07895 SCO2 - Protein SCO2 homolog, mitochondrial precursor - Bos taurus (Bovine) - SCO2 gene Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2. Taurus_UMD|evm.model.AC_000162.1.1280 A8MYP8 ODF3B_HUMAN 81.746 0.943609 1.05138 ODF3B - Outer dense fiber protein 3B - Homo sapiens (Human) - ODF3B gene cytoskeleton Taurus_UMD|evm.model.AC_000162.1.1281 Q96G42 KLD7B_HUMAN 69.307 0.51086 1.93771 KLHDC7B - Kelch domain-containing protein 7B - Homo sapiens (Human) - KLHDC7B gene Taurus_UMD|evm.model.AC_000162.1.1282 B5KM66 SYCE3_MOUSE 92.045 0.945652 1.04545 Syce3 - Synaptonemal complex central element protein 3 - Mus musculus (Mouse) - Syce3 gene Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility. May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism. Taurus_UMD|evm.model.AC_000162.1.1283 Q58DK1 CPT1B_BOVIN 100.000 0.997409 1.0013 CPT1B - Carnitine O-palmitoyltransferase 1, muscle isoform - Bos taurus (Bovine) - CPT1B gene mitochondrion, carnitine O-palmitoyltransferase activity, carnitine metabolic process, fatty acid metabolic process, long-chain fatty acid transport, response to blue light Taurus_UMD|evm.model.AC_000162.1.1284 Q9Y259 CHKB_HUMAN 88.354 0.994949 1.00253 CHKB - Choline/ethanolamine kinase - Homo sapiens (Human) - CHKB gene Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis. Taurus_UMD|evm.model.AC_000162.1.1285 Q13387 JIP2_HUMAN 88.087 0.997567 0.997573 MAPK8IP2 - C-Jun-amino-terminal kinase-interacting protein 2 - Homo sapiens (Human) - MAPK8IP2 gene The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Taurus_UMD|evm.model.AC_000162.1.1286 Q08DD1 ARSA_BOVIN 100.000 0.996063 1.00197 ARSA - Arylsulfatase A precursor - Bos taurus (Bovine) - ARSA gene Hydrolyzes cerebroside sulfate. Taurus_UMD|evm.model.AC_000162.1.1287 Q9BYB0 SHAN3_HUMAN 95.923 0.234729 1.02137 SHANK3 - SH3 and multiple ankyrin repeat domains protein 3 - Homo sapiens (Human) - SHANK3 gene Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. Taurus_UMD|evm.model.AC_000162.1.1288 Q9GL10 ACRO_SHEEP 91.667 0.68578 1.32523 ACR - Acrosin precursor - Ovis aries (Sheep) - ACR gene Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. Taurus_UMD|evm.model.AC_000162.1.1289 Q9UBK7 RBL2A_HUMAN 85.268 0.982379 0.995614 RABL2A - Rab-like protein 2A - Homo sapiens (Human) - RABL2A gene Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail. Taurus_UMD|evm.model.AC_000162.1.1296 Q0VD83 APOBR_HUMAN 44.000 0.226027 0.399271 APOBR - Apolipoprotein B receptor - Homo sapiens (Human) - APOBR gene Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. Taurus_UMD|evm.model.AC_000162.1.1297 Q923G5 ZDHC7_RAT 41.569 0.480493 1.58117 Zdhhc7 - Palmitoyltransferase ZDHHC7 - Rattus norvegicus (Rat) - Zdhhc7 gene Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones. Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways. Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane. In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation. Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration (By similarity). Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane. In brain, could also palmitoylate SNAP25 and DLG4/PSD95. Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane. Could also palmitoylate NCDN (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (PubMed:11796495). Taurus_UMD|evm.model.AC_000162.1.1299 O95696 BRD1_HUMAN 93.015 0.223782 1.14461 BRD1 - Bromodomain-containing protein 1 - Homo sapiens (Human) - BRD1 gene Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). Taurus_UMD|evm.model.AC_000162.1.1302 O75132 ZBED4_HUMAN 81.349 0.969191 0.665243 ZBED4 - Zinc finger BED domain-containing protein 4 - Homo sapiens (Human) - ZBED4 gene Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA (By similarity). Taurus_UMD|evm.model.AC_000162.1.1303 Q9BV10 ALG12_HUMAN 79.796 0.993902 1.0082 ALG12 - Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase - Homo sapiens (Human) - ALG12 gene Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Taurus_UMD|evm.model.AC_000162.1.1304 Q2KIT5 CREL2_BOVIN 100.000 0.994318 1.00285 CRELD2 - Protein disulfide isomerase CRELD2 precursor - Bos taurus (Bovine) - CRELD2 gene Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (By similarity). Taurus_UMD|evm.model.AC_000162.1.1305 O70444 PIM3_RAT 95.092 0.993884 1.00307 Pim3 - Serine/threonine-protein kinase pim-3 - Rattus norvegicus (Rat) - Pim3 gene Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth (By similarity). Taurus_UMD|evm.model.AC_000162.1.1307 Q6ZVW7 I17EL_HUMAN 68.831 0.668142 1.34524 IL17REL - Putative interleukin-17 receptor E-like - Homo sapiens (Human) - IL17REL gene interleukin-17 receptor activity Taurus_UMD|evm.model.AC_000162.1.1308 A4Q9F1 TTLL8_MOUSE 75.649 0.689342 0.530048 Ttll8 - Protein monoglycylase TTLL8 - Mus musculus (Mouse) - Ttll8 gene Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction. Taurus_UMD|evm.model.AC_000162.1.1309 Q15049 MLC1_HUMAN 81.419 0.405517 1.92308 MLC1 - Membrane protein MLC1 - Homo sapiens (Human) - MLC1 gene Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. Taurus_UMD|evm.model.AC_000162.1.1310 Q99MV5 M10L1_MOUSE 86.083 0.422785 0.998315 Mov10l1 - RNA helicase Mov10l1 - Mus musculus (Mouse) - Mov10l1 gene ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Involved in the primary piRNA metabolic process (PubMed:20534472, PubMed:20547853, PubMed:23166510, PubMed:25762440). Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins (PubMed:25762440). Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins (PubMed:25762440). Taurus_UMD|evm.model.AC_000162.1.1311 Q96RD6 PANX2_HUMAN 89.104 0.996956 0.970458 PANX2 - Pannexin-2 - Homo sapiens (Human) - PANX2 gene Structural component of the gap junctions and the hemichannels. Taurus_UMD|evm.model.AC_000162.1.1312 Q58DF3 TRABD_BOVIN 100.000 0.994709 1.00265 TRABD - TraB domain-containing protein - Bos taurus (Bovine) - TRABD gene Taurus_UMD|evm.model.AC_000163.1.1 Q8NGL4 OR5DD_HUMAN 70.588 0.94382 0.283439 OR5D13 - Olfactory receptor 5D13 - Homo sapiens (Human) - OR5D13 gene Odorant receptor. Taurus_UMD|evm.model.AC_000163.1.2 Q8NGL4 OR5DD_HUMAN 75.172 0.923077 0.496815 OR5D13 - Olfactory receptor 5D13 - Homo sapiens (Human) - OR5D13 gene Odorant receptor. Taurus_UMD|evm.model.AC_000163.1.3 Q8NGL4 OR5DD_HUMAN 72.321 0.991071 0.356688 OR5D13 - Olfactory receptor 5D13 - Homo sapiens (Human) - OR5D13 gene Odorant receptor. Taurus_UMD|evm.model.AC_000163.1.4 Q8NH69 OR5W2_HUMAN 73.494 0.97619 0.270968 OR5W2 - Olfactory receptor 5W2 - Homo sapiens (Human) - OR5W2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000163.1.5 O46414 FRIH_BOVIN 94.853 0.964286 0.773481 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000163.1.6 P15103 GLNA_BOVIN 80.488 0.289855 0.369973 GLUL - Glutamine synthetase - Bos taurus (Bovine) - GLUL gene Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). Taurus_UMD|evm.model.AC_000163.1.7 Q8TCQ1 MARH1_HUMAN 86.640 0.97619 0.871972 MARCHF1 - E3 ubiquitin-protein ligase MARCHF1 - Homo sapiens (Human) - MARCHF1 gene E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. Taurus_UMD|evm.model.AC_000163.1.8 Q3T071 TMA16_BOVIN 99.507 0.990196 1.00493 TMA16 - Translation machinery-associated protein 16 - Bos taurus (Bovine) - TMA16 gene nucleus Taurus_UMD|evm.model.AC_000163.1.9 Q2NKZ4 TKTL2_BOVIN 100.000 0.99681 1.0016 TKTL2 - Transketolase-like protein 2 - Bos taurus (Bovine) - TKTL2 gene Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis (By similarity). Taurus_UMD|evm.model.AC_000163.1.10 O62729 NPY5R_CANLF 91.256 0.995526 1.00224 NPY5R - Neuropeptide Y receptor type 5 - Canis lupus familiaris (Dog) - NPY5R gene Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (By similarity). Taurus_UMD|evm.model.AC_000163.1.12 Q1RMU8 NPY1R_BOVIN 100.000 0.994792 1.00261 NPY1R - Neuropeptide Y receptor type 1 - Bos taurus (Bovine) - NPY1R gene Receptor for neuropeptide Y and peptide YY. Taurus_UMD|evm.model.AC_000163.1.14 Q96HR8 NAF1_HUMAN 84.527 0.75817 0.92915 NAF1 - H/ACA ribonucleoprotein complex non-core subunit NAF1 - Homo sapiens (Human) - NAF1 gene RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. Taurus_UMD|evm.model.AC_000163.1.15 Q8IWZ6 BBS7_HUMAN 94.126 0.997207 1.0014 BBS7 - Bardet-Biedl syndrome 7 protein - Homo sapiens (Human) - BBS7 gene The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Taurus_UMD|evm.model.AC_000163.1.16 P30274 CCNA2_BOVIN 99.767 0.995349 1 CCNA2 - Cyclin-A2 - Bos taurus (Bovine) - CCNA2 gene Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Taurus_UMD|evm.model.AC_000163.1.17 Q3SWZ4 EXOS9_BOVIN 99.773 0.995465 1.00227 EXOSC9 - Exosome complex component RRP45 - Bos taurus (Bovine) - EXOSC9 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs (By similarity). Taurus_UMD|evm.model.AC_000163.1.18 P81287 ANXA5_BOVIN 99.688 0.993789 1.00312 ANXA5 - Annexin A5 - Bos taurus (Bovine) - ANXA5 gene This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Taurus_UMD|evm.model.AC_000163.1.19 Q4R8K5 IF4A1_MACFA 65.812 0.658385 0.396552 EIF4A1 - Eukaryotic initiation factor 4A-I - Macaca fascicularis (Crab-eating macaque) - EIF4A1 gene ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). Taurus_UMD|evm.model.AC_000163.1.20 Q96P65 QRFPR_HUMAN 91.415 0.99537 1.00232 QRFPR - Pyroglutamylated RF-amide peptide receptor - Homo sapiens (Human) - QRFPR gene Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels. Taurus_UMD|evm.model.AC_000163.1.21 Q8TB73 NDNF_HUMAN 93.465 0.965517 0.919014 NDNF - Protein NDNF precursor - Homo sapiens (Human) - NDNF gene Secretory protein that plays a role in various cellular processes (PubMed:20969804, PubMed:24706764, PubMed:31883645). Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645). Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:20969804, PubMed:31883645). May also act through the regulation of growth factors activity and downstream signaling (PubMed:31883645). Also regulates extracellular matrix assembly and cell adhesiveness (By similarity). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764). Taurus_UMD|evm.model.AC_000163.1.22 Q9NQX1 PRDM5_HUMAN 91.141 0.996409 0.884127 PRDM5 - PR domain zinc finger protein 5 - Homo sapiens (Human) - PRDM5 gene Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells. Taurus_UMD|evm.model.AC_000163.1.23 Q6REY9 RHG20_RAT 59.459 0.143426 0.212352 Arhgap20 - Rho GTPase-activating protein 20 - Rattus norvegicus (Rat) - Arhgap20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000163.1.25 Q9P2F6 RHG20_HUMAN 60.465 0.363636 0.184719 ARHGAP20 - Rho GTPase-activating protein 20 - Homo sapiens (Human) - ARHGAP20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000163.1.26 Q6REY9 RHG20_RAT 82.000 0.0656836 0.631134 Arhgap20 - Rho GTPase-activating protein 20 - Rattus norvegicus (Rat) - Arhgap20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000163.1.28 Q13257 MD2L1_HUMAN 93.243 0.257143 1.36585 MAD2L1 - Mitotic spindle assembly checkpoint protein MAD2A - Homo sapiens (Human) - MAD2L1 gene Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:29162720, PubMed:15024386). In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2 (PubMed:29162720). Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (PubMed:10700282, PubMed:11804586, PubMed:15024386). Taurus_UMD|evm.model.AC_000163.1.30 Q6REY9 RHG20_RAT 55.000 0.37013 0.130288 Arhgap20 - Rho GTPase-activating protein 20 - Rattus norvegicus (Rat) - Arhgap20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000163.1.31 Q9P2F6 RHG20_HUMAN 66.154 0.381818 0.415617 ARHGAP20 - Rho GTPase-activating protein 20 - Homo sapiens (Human) - ARHGAP20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000163.1.32 Q13257 MD2L1_HUMAN 98.537 0.990291 1.00488 MAD2L1 - Mitotic spindle assembly checkpoint protein MAD2A - Homo sapiens (Human) - MAD2L1 gene Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:29162720, PubMed:15024386). In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2 (PubMed:29162720). Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (PubMed:10700282, PubMed:11804586, PubMed:15024386). Taurus_UMD|evm.model.AC_000163.1.34 Q9P2F6 RHG20_HUMAN 68.205 0.458034 0.350126 ARHGAP20 - Rho GTPase-activating protein 20 - Homo sapiens (Human) - ARHGAP20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000163.1.37 P31621 ENV_JSRV 29.126 0.915888 0.173984 env - Envelope glycoprotein precursor - Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) - env gene The envelope proteins induce cell transformation leading to ovine pulmonary adenocarcinoma (OPA), a contagious lung cancer of sheep and goat. They bind to the HYAL2 receptor for cell entry. Env proteins probably do not act as oncogenes by themselves, but may rather liberate an oncogenic factor that would normally be negatively regulated. One mechanism of transformation seems to involve activation of the phosphoinositide-3-OH kinase (PI3K)/Akt pathway but does not involve the virus receptor HYAL2, and the other seems to involve Env binding to HYAL2, HYAL2 degradation, and activation of the MST1R receptor tyrosine kinase, which is normally suppressed by HYAL2. Taurus_UMD|evm.model.AC_000163.1.38 Q6REY9 RHG20_RAT 59.127 0.528908 0.395093 Arhgap20 - Rho GTPase-activating protein 20 - Rattus norvegicus (Rat) - Arhgap20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000163.1.39 Q28156 PDE5A_BOVIN 100.000 0.997691 1.00116 PDE5A - cGMP-specific 3',5'-cyclic phosphodiesterase - Bos taurus (Bovine) - PDE5A gene Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:8530505). Specifically regulates nitric-oxide-generated cGMP (By similarity). Taurus_UMD|evm.model.AC_000163.1.40 Q56JX9 FABPI_BOVIN 94.167 0.983193 0.901515 FABP2 - Fatty acid-binding protein, intestinal - Bos taurus (Bovine) - FABP2 gene FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor (By similarity). Taurus_UMD|evm.model.AC_000163.1.41 Q8WVX3 CD003_HUMAN 72.059 0.697917 1.45455 C4orf3 - Uncharacterized protein C4orf3 - Homo sapiens (Human) - C4orf3 gene Taurus_UMD|evm.model.AC_000163.1.42 Q70EK8 UBP53_HUMAN 78.611 0.968015 0.99068 USP53 - Inactive ubiquitin carboxyl-terminal hydrolase 53 - Homo sapiens (Human) - USP53 gene Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (By similarity). Has no peptidase activity (PubMed:14715245). Taurus_UMD|evm.model.AC_000163.1.43 Q5E9V3 MYOZ2_BOVIN 100.000 0.990291 0.780303 MYOZ2 - Myozenin-2 - Bos taurus (Bovine) - MYOZ2 gene Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity). Taurus_UMD|evm.model.AC_000163.1.44 Q9UMS6 SYNP2_HUMAN 86.563 0.998167 0.99817 SYNPO2 - Synaptopodin-2 - Homo sapiens (Human) - SYNPO2 gene Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). Taurus_UMD|evm.model.AC_000163.1.45 O94855 SC24D_HUMAN 92.443 0.986708 0.947674 SEC24D - Protein transport protein Sec24D - Homo sapiens (Human) - SEC24D gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). Taurus_UMD|evm.model.AC_000163.1.46 A4IFD8 MET14_BOVIN 99.781 0.995624 1.00219 METTL14 - N6-adenosine-methyltransferase non-catalytic subunit - Bos taurus (Bovine) - METTL14 gene The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (By similarity). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). Taurus_UMD|evm.model.AC_000163.1.47 Q5G270 NETR_GORGO 83.196 0.77931 0.827626 PRSS12 - Neurotrypsin precursor - Gorilla gorilla gorilla (Western lowland gorilla) - PRSS12 gene Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. Taurus_UMD|evm.model.AC_000163.1.48 Q5E947 PRDX1_BOVIN 79.259 0.930556 0.723618 PRDX1 - Peroxiredoxin-1 - Bos taurus (Bovine) - PRDX1 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). Taurus_UMD|evm.model.AC_000163.1.49 O95803 NDST3_HUMAN 96.000 0.597802 0.521191 NDST3 - Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 - Homo sapiens (Human) - NDST3 gene Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity. Taurus_UMD|evm.model.AC_000163.1.50 Q99880 H2B1L_HUMAN 79.365 0.868056 1.14286 H2BC13 - Histone H2B type 1-L - Homo sapiens (Human) - H2BC13 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000163.1.51 Q9WTX6 CUL1_MOUSE 72.678 0.298025 0.717784 Cul1 - Cullin-1 - Mus musculus (Mouse) - Cul1 gene Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Taurus_UMD|evm.model.AC_000163.1.52 Q8N609 TR1L1_HUMAN 71.053 0.856818 1.19241 TRAM1L1 - Translocating chain-associated membrane protein 1-like 1 - Homo sapiens (Human) - TRAM1L1 gene Stimulatory or required for the translocation of secretory proteins across the ER membrane. Taurus_UMD|evm.model.AC_000163.1.55 O77834 PRDX6_BOVIN 84.783 0.892157 0.455357 PRDX6 - Peroxiredoxin-6 - Bos taurus (Bovine) - PRDX6 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10409692, PubMed:2373154). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10409692). Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10409692, PubMed:2373154, PubMed:9787801). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity). Taurus_UMD|evm.model.AC_000163.1.56 Q5R893 H2B1_PONAB 94.186 0.85 0.793651 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000163.1.58 Q3ZBE1 ARMC1_BOVIN 87.755 0.262295 0.648936 ARMC1 - Armadillo repeat-containing protein 1 - Bos taurus (Bovine) - ARMC1 gene In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility. Taurus_UMD|evm.model.AC_000163.1.59 Q9H3R1 NDST4_HUMAN 90.857 0.983099 0.40711 NDST4 - Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 - Homo sapiens (Human) - NDST4 gene Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity). Taurus_UMD|evm.model.AC_000163.1.61 Q9H3R1 NDST4_HUMAN 92.687 0.983051 0.608945 NDST4 - Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 - Homo sapiens (Human) - NDST4 gene Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity). Taurus_UMD|evm.model.AC_000163.1.62 Q16880 CGT_HUMAN 95.194 0.981818 1.01664 UGT8 - 2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor - Homo sapiens (Human) - UGT8 gene Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system (PubMed:9125199). Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides (By similarity). Taurus_UMD|evm.model.AC_000163.1.63 Q5R7J9 IF4G2_PONAB 91.120 0.763314 0.372657 EIF4G2 - Eukaryotic translation initiation factor 4 gamma 2 - Pongo abelii (Sumatran orangutan) - EIF4G2 gene Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases (By similarity). Taurus_UMD|evm.model.AC_000163.1.64 P84100 RL19_RAT 60.584 0.677019 0.821429 Rpl19 - 60S ribosomal protein L19 - Rattus norvegicus (Rat) - Rpl19 gene cytosolic large ribosomal subunit, polysomal ribosome, synapse, 5.8S rRNA binding, large ribosomal subunit rRNA binding, RNA binding, structural constituent of ribosome, cytoplasmic translation, liver regeneration Taurus_UMD|evm.model.AC_000163.1.65 Q5FYB0 ARSJ_HUMAN 90.090 0.916667 0.200334 ARSJ - Arylsulfatase J precursor - Homo sapiens (Human) - ARSJ gene actin cytoskeleton, endoplasmic reticulum lumen, arylsulfatase activity Taurus_UMD|evm.model.AC_000163.1.66 Q5FYB0 ARSJ_HUMAN 94.206 0.964657 0.803005 ARSJ - Arylsulfatase J precursor - Homo sapiens (Human) - ARSJ gene actin cytoskeleton, endoplasmic reticulum lumen, arylsulfatase activity Taurus_UMD|evm.model.AC_000163.1.67 Q95266 KCC2D_PIG 100.000 0.993737 0.95992 CAMK2D - Calcium/calmodulin-dependent protein kinase type II subunit delta - Sus scrofa (Pig) - CAMK2D gene Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor (By similarity). Taurus_UMD|evm.model.AC_000163.1.68 Q01484 ANK2_HUMAN 80.241 0.948985 0.946171 ANK2 - Ankyrin-2 - Homo sapiens (Human) - ANK2 gene Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). Taurus_UMD|evm.model.AC_000163.1.69 Q8C8R3 ANK2_MOUSE 98.485 0.984848 0.0169318 Ank2 - Ankyrin-2 - Mus musculus (Mouse) - Ank2 gene Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (PubMed:19109891). In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites (PubMed:12571597). Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:15262991). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (PubMed:19007774). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (PubMed:27718357). Taurus_UMD|evm.model.AC_000163.1.71 Q4G0J3 LARP7_HUMAN 85.739 0.996546 0.994845 LARP7 - La-related protein 7 - Homo sapiens (Human) - LARP7 gene RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18483487, PubMed:18281698). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity). Taurus_UMD|evm.model.AC_000163.1.72 Q86YA3 ZGRF1_HUMAN 71.811 0.954054 1.05513 ZGRF1 - Protein ZGRF1 - Homo sapiens (Human) - ZGRF1 gene cytoplasm, 5'-flap endonuclease activity, RNA binding, replication fork reversal Taurus_UMD|evm.model.AC_000163.1.74 Q9H2A3 NGN2_HUMAN 91.544 0.99262 0.996324 NEUROG2 - Neurogenin-2 - Homo sapiens (Human) - NEUROG2 gene Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Taurus_UMD|evm.model.AC_000163.1.75 Q96QP1 ALPK1_HUMAN 77.311 0.0985556 0.946141 ALPK1 - Alpha-protein kinase 1 - Homo sapiens (Human) - ALPK1 gene Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (PubMed:28877472, PubMed:28222186, PubMed:30111836). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836). ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (PubMed:30111836). May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (PubMed:27169898). May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (PubMed:15883161). Taurus_UMD|evm.model.AC_000163.1.76 A2VDM0 TIFA_BOVIN 100.000 0.989247 1.00541 TIFA - TRAF-interacting protein with FHA domain-containing protein A - Bos taurus (Bovine) - TIFA gene Adapter molecule that plays a key role in the activation of proinflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of proinflammatory NF-kappa-B signaling. Taurus_UMD|evm.model.AC_000163.1.77 Q63HQ0 AP1AR_HUMAN 94.040 0.993399 1.00331 AP1AR - AP-1 complex-associated regulatory protein - Homo sapiens (Human) - AP1AR gene Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. Taurus_UMD|evm.model.AC_000163.1.81 Q17QE0 F241A_BOVIN 100.000 0.985612 1.00725 FAM241A - Uncharacterized protein FAM241A - Bos taurus (Bovine) - FAM241A gene intracellular membrane-bounded organelle Taurus_UMD|evm.model.AC_000163.1.82 P08548 LIN1_NYCCO 64.319 0.889362 0.186508 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Taurus_UMD|evm.model.AC_000163.1.83 Q5R651 1433Z_PONAB 63.830 0.970149 0.546939 YWHAZ - 14-3-3 protein zeta/delta - Pongo abelii (Sumatran orangutan) - YWHAZ gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). Taurus_UMD|evm.model.AC_000163.1.85 P97474 PITX2_MOUSE 74.603 0.690141 0.223975 Pitx2 - Pituitary homeobox 2 - Mus musculus (Mouse) - Pitx2 gene Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform Ptx2c is involved in left-right asymmetry the developing embryo. Taurus_UMD|evm.model.AC_000163.1.86 Q9R0W1 PITX2_RAT 96.308 0.993865 1.00617 Pitx2 - Pituitary homeobox 2 - Rattus norvegicus (Rat) - Pitx2 gene Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach (By similarity). Taurus_UMD|evm.model.AC_000163.1.87 Q32LQ0 AMPE_BOVIN 99.791 0.99791 1.00105 ENPEP - Glutamyl aminopeptidase - Bos taurus (Bovine) - ENPEP gene Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. Taurus_UMD|evm.model.AC_000163.1.88 Q4R7Y2 RL10_MACFA 71.739 0.775862 0.271028 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000163.1.89 P62309 RUXG_MOUSE 98.684 0.974026 1.01316 Snrpg - Small nuclear ribonucleoprotein G - Mus musculus (Mouse) - Snrpg gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. Taurus_UMD|evm.model.AC_000163.1.90 Q9H5J4 ELOV6_HUMAN 94.318 0.992453 1 ELOVL6 - Elongation of very long chain fatty acids protein 6 - Homo sapiens (Human) - ELOVL6 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Taurus_UMD|evm.model.AC_000163.1.91 Q00968 EGF_PIG 72.222 0.0956284 0.301483 EGF - Pro-epidermal growth factor precursor - Sus scrofa (Pig) - EGF gene EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). Taurus_UMD|evm.model.AC_000163.1.92 O14718 OPSX_HUMAN 89.273 0.231698 3.68843 RRH - Visual pigment-like receptor peropsin - Homo sapiens (Human) - RRH gene May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds. Taurus_UMD|evm.model.AC_000163.1.93 Q9WUW3 CFAI_RAT 69.036 0.917609 1.02483 Cfi - Complement factor I precursor - Rattus norvegicus (Rat) - Cfi gene Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization. Taurus_UMD|evm.model.AC_000163.1.94 Q9BZM1 PG12A_HUMAN 94.828 0.930108 0.984127 PLA2G12A - Group XIIA secretory phospholipase A2 precursor - Homo sapiens (Human) - PLA2G12A gene PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine. Taurus_UMD|evm.model.AC_000163.1.95 Q3T0P5 CASP6_BOVIN 99.659 0.993197 1.00341 CASP6 - Caspase-6 precursor - Bos taurus (Bovine) - CASP6 gene Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity. During apoptosis, localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation. Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP (By similarity). Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis. Regulates B-cell programs both during early development and after antigen stimulation (By similarity). In addition, promotes the ZBP1-mediated activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in defense against viruses. Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death (By similarity). Taurus_UMD|evm.model.AC_000163.1.96 Q9NWR8 MCUB_HUMAN 80.896 0.988095 1 MCUB - Calcium uniporter regulatory subunit MCUb, mitochondrial precursor - Homo sapiens (Human) - MCUB gene Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Taurus_UMD|evm.model.AC_000163.1.97 O95487 SC24B_HUMAN 92.283 0.998406 0.989748 SEC24B - Protein transport protein Sec24B - Homo sapiens (Human) - SEC24B gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296). Taurus_UMD|evm.model.AC_000163.1.98 Q9BXS0 COPA1_HUMAN 80.808 0.989899 0.151376 COL25A1 - Collagen alpha-1(XXV) chain - Homo sapiens (Human) - COL25A1 gene Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. Taurus_UMD|evm.model.AC_000163.1.99 Q9BXS0 COPA1_HUMAN 88.768 0.965385 0.397554 COL25A1 - Collagen alpha-1(XXV) chain - Homo sapiens (Human) - COL25A1 gene Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. Taurus_UMD|evm.model.AC_000163.1.101 Q5E9S4 AT2L1_BOVIN 100.000 0.995984 1.00201 ETNPPL - Ethanolamine-phosphate phospho-lyase - Bos taurus (Bovine) - ETNPPL gene Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde. Taurus_UMD|evm.model.AC_000163.1.102 Q2KID7 OSTC_BOVIN 100.000 0.986667 1.00671 OSTC - Oligosaccharyltransferase complex subunit OSTC - Bos taurus (Bovine) - OSTC gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. Taurus_UMD|evm.model.AC_000163.1.103 Q29223 RL34_PIG 100.000 0.983051 1.00855 RPL34 - 60S ribosomal protein L34 - Sus scrofa (Pig) - RPL34 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000163.1.105 Q9UJU2 LEF1_HUMAN 98.972 0.93494 1.0401 LEF1 - Lymphoid enhancer-binding factor 1 - Homo sapiens (Human) - LEF1 gene Transcription factor that binds DNA in a sequence-specific manner (PubMed:2010090). Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PubMed:11266540). Regulates T-cell receptor alpha enhancer function (PubMed:19653274). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity). Taurus_UMD|evm.model.AC_000163.1.106 Q0IIF9 CP2U1_BOVIN 99.767 0.56168 1.40331 CYP2U1 - Cytochrome P450 2U1 - Bos taurus (Bovine) - CYP2U1 gene A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May downregulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin. Taurus_UMD|evm.model.AC_000163.1.107 Q4R763 SMS2_MACFA 95.890 0.994536 1.00274 SGMS2 - Phosphatidylcholine:ceramide cholinephosphotransferase 2 - Macaca fascicularis (Crab-eating macaque) - SGMS2 gene Sphingomyelin synthase that primarily contributes to sphingomyelin synthesis and homeostasis at the plasma membrane. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction appears to depend on the levels of CER and DAG in the plasma membrane. Does not use free phosphorylcholine or CDP-choline as donors. Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to ceramide (CER) to form ceramide phosphoethanolamine (CPE). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting. To a lesser extent, plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1. Required for normal bone matrix mineralization. Taurus_UMD|evm.model.AC_000163.1.108 O43252 PAPS1_HUMAN 98.397 0.9968 1.0016 PAPSS1 - Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 - Homo sapiens (Human) - PAPSS1 gene Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121, PubMed:9648242, PubMed:14747722). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487). Taurus_UMD|evm.model.AC_000163.1.109 Q9UBU2 DKK2_HUMAN 95.753 0.992308 1.00386 DKK2 - Dickkopf-related protein 2 precursor - Homo sapiens (Human) - DKK2 gene Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). Taurus_UMD|evm.model.AC_000163.1.110 Q10126 YSM6_CAEEL 27.879 0.424855 1.24014 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000163.1.111 O02751 CFDP2_BOVIN 78.505 0.990698 0.363176 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000163.1.112 P0DJR0 GIMD1_HUMAN 85.496 0.783133 0.764977 GIMD1 - GTPase IMAP family member GIMD1 - Homo sapiens (Human) - GIMD1 gene Taurus_UMD|evm.model.AC_000163.1.113 Q12904 AIMP1_HUMAN 86.581 0.993631 1.00641 AIMP1 - Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 - Homo sapiens (Human) - AIMP1 gene Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550). Taurus_UMD|evm.model.AC_000163.1.114 Q8TEA7 TBCK_HUMAN 96.417 0.997763 1.00112 TBCK - TBC domain-containing protein kinase-like protein - Homo sapiens (Human) - TBCK gene Involved in the modulation of mTOR signaling and expression of mTOR complex components (PubMed:27040691, PubMed:23977024). Involved in the regulation of cell proliferation and growth (PubMed:23977024, PubMed:24576458). Involved in the control of actin-cytoskeleton organization (PubMed:23977024). Taurus_UMD|evm.model.AC_000163.1.115 Q63610 TPM3_RAT 88.583 0.992157 1.02823 Tpm3 - Tropomyosin alpha-3 chain - Rattus norvegicus (Rat) - Tpm3 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Taurus_UMD|evm.model.AC_000163.1.116 Q66X52 LTOR5_PIG 84.722 0.533835 1.46154 LAMTOR5 - Ragulator complex protein LAMTOR5 - Sus scrofa (Pig) - LAMTOR5 gene As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Taurus_UMD|evm.model.AC_000163.1.117 Q6UXI9 NPNT_HUMAN 83.158 0.987698 1.00708 NPNT - Nephronectin precursor - Homo sapiens (Human) - NPNT gene Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity). Taurus_UMD|evm.model.AC_000163.1.118 A5PKL6 GSTCD_BOVIN 99.478 0.959799 0.630745 GSTCD - Glutathione S-transferase C-terminal domain-containing protein - Bos taurus (Bovine) - GSTCD gene cytoplasm Taurus_UMD|evm.model.AC_000163.1.119 Q32LL5 INT12_BOVIN 100.000 0.99568 1.00216 INTS12 - Integrator complex subunit 12 - Bos taurus (Bovine) - INTS12 gene Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Taurus_UMD|evm.model.AC_000163.1.120 Q9NXL2 ARH38_HUMAN 87.744 0.997396 0.988417 ARHGEF38 - Rho guanine nucleotide exchange factor 38 - Homo sapiens (Human) - ARHGEF38 gene May act as a guanine-nucleotide releasing factor. Taurus_UMD|evm.model.AC_000163.1.121 Q9H2U2 IPYR2_HUMAN 82.456 0.994169 1.02695 PPA2 - Inorganic pyrophosphatase 2, mitochondrial precursor - Homo sapiens (Human) - PPA2 gene Hydrolyzes inorganic pyrophosphate (PubMed:27523597). This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function (PubMed:27523598). Taurus_UMD|evm.model.AC_000163.1.122 Q6N021 TET2_HUMAN 81.432 0.999004 1.003 TET2 - Methylcytosine dioxygenase TET2 - Homo sapiens (Human) - TET2 gene Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Taurus_UMD|evm.model.AC_000163.1.125 Q9EQC9 CXXC4_RAT 89.116 0.833333 0.878788 Cxxc4 - CXXC-type zinc finger protein 4 - Rattus norvegicus (Rat) - Cxxc4 gene Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity). Taurus_UMD|evm.model.AC_000163.1.127 O97512 NK3R_RABIT 90.476 0.791209 0.389722 TACR3 - Neuromedin-K receptor - Oryctolagus cuniculus (Rabbit) - TACR3 gene This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Taurus_UMD|evm.model.AC_000163.1.128 P62262 1433E_SHEEP 90.090 0.982143 0.439216 YWHAE - 14-3-3 protein epsilon - Ovis aries (Sheep) - YWHAE gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Taurus_UMD|evm.model.AC_000163.1.129 O97512 NK3R_RABIT 94.340 0.78607 0.430407 TACR3 - Neuromedin-K receptor - Oryctolagus cuniculus (Rabbit) - TACR3 gene This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Taurus_UMD|evm.model.AC_000163.1.130 Q32PC9 AR2BP_BOVIN 75.385 0.666667 0.588957 ARL2BP - ADP-ribosylation factor-like protein 2-binding protein - Bos taurus (Bovine) - ARL2BP gene Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity). Taurus_UMD|evm.model.AC_000163.1.131 Q02224 CENPE_HUMAN 70.224 0.98136 1.01296 CENPE - Centromere-associated protein E precursor - Homo sapiens (Human) - CENPE gene Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:7889940, PubMed:23891108, PubMed:25395579). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). Taurus_UMD|evm.model.AC_000163.1.132 Q3T046 BDH2_BOVIN 99.592 0.99187 1.00408 BDH2 - 3-hydroxybutyrate dehydrogenase type 2 - Bos taurus (Bovine) - BDH2 gene Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). Taurus_UMD|evm.model.AC_000163.1.133 Q86UD5 SL9B2_HUMAN 83.426 0.996269 0.998138 SLC9B2 - Sodium/hydrogen exchanger 9B2 - Homo sapiens (Human) - SLC9B2 gene Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966). Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity). Taurus_UMD|evm.model.AC_000163.1.134 Q4ZJI4 SL9B1_HUMAN 68.023 0.996109 0.998058 SLC9B1 - Sodium/hydrogen exchanger 9B1 - Homo sapiens (Human) - SLC9B1 gene Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility. Taurus_UMD|evm.model.AC_000163.1.135 Q8N5K1 CISD2_HUMAN 100.000 0.985294 1.00741 CISD2 - CDGSH iron-sulfur domain-containing protein 2 - Homo sapiens (Human) - CISD2 gene Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. Taurus_UMD|evm.model.AC_000163.1.136 P61078 UB2D3_RAT 100.000 0.822485 1.14966 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Taurus_UMD|evm.model.AC_000163.1.137 Q29444 MANBA_BOVIN 89.205 0.544194 0.656428 MANBA - Beta-mannosidase precursor - Bos taurus (Bovine) - MANBA gene Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides. Taurus_UMD|evm.model.AC_000163.1.138 Q6F3J0 NFKB1_CANLF 92.593 0.997938 0.997942 NFKB1 - Nuclear factor NF-kappa-B p105 subunit - Canis lupus familiaris (Dog) - NFKB1 gene NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105 (By similarity). Taurus_UMD|evm.model.AC_000163.1.139 Q99877 H2B1N_HUMAN 95.946 0.935897 0.619048 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000163.1.140 Q9C0K1 S39A8_HUMAN 92.191 0.995671 1.00435 SLC39A8 - Metal cation symporter ZIP8 precursor - Homo sapiens (Human) - SLC39A8 gene Electroneutral transporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis or immunity (PubMed:12504855, PubMed:22898811, PubMed:23403290, PubMed:29337306, PubMed:26637978, PubMed:29453449). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation, a bicarbonate and a selenite anion or yet a metal cation and two bicarbonate anions (PubMed:27166256, PubMed:31699897). May also transport iron, mercury and cobalt through membranes (PubMed:22898811). Beside these endogenous cellular substrates, also imports cadmium a non-essential metal which is cytotoxic and carcinogenic (PubMed:27466201). Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development (PubMed:29337306). Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization (PubMed:29927450). Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes (PubMed:23403290, PubMed:28056086). Protects, for instance, cells from injury and death at the onset of inflammation (PubMed:18390834). By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (By similarity). At the apical membrane of hepatocytes, reclaims manganese from the bile and regulates, through the systemic levels of the nutrient, the activity of manganese-dependent enzymes (PubMed:28481222). Also participates in manganese reabsorption in the proximal tubule of the kidney (PubMed:26637978). By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain (PubMed:26637978, PubMed:31699897). Through manganese cellular uptake also participates in mitochondrial proper function (PubMed:29453449). Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR-mediated T cell activation (PubMed:19401385). Taurus_UMD|evm.model.AC_000163.1.141 Q8NDB2 BANK1_HUMAN 74.268 0.997439 0.994904 BANK1 - B-cell scaffold protein with ankyrin repeats - Homo sapiens (Human) - BANK1 gene Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. Taurus_UMD|evm.model.AC_000163.1.142 P48452 PP2BA_BOVIN 100.000 0.996169 1.00192 PPP3CA - Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform - Bos taurus (Bovine) - PPP3CA gene Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15967565, PubMed:1715244, PubMed:1328240, PubMed:16411749). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (By similarity). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (By similarity). Dephosphorylates heat shock protein HSPB1 (PubMed:1328240). Dephosphorylates and activates transcription factor NFATC1 (By similarity). Dephosphorylates and inactivates transcription factor ELK1 (By similarity). Dephosphorylates DARPP32 (By similarity). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (By similarity). Taurus_UMD|evm.model.AC_000163.1.144 Q9ULC0 MUCEN_HUMAN 56.489 0.992366 1.00383 EMCN - Endomucin precursor - Homo sapiens (Human) - EMCN gene Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. Taurus_UMD|evm.model.AC_000163.1.145 A2VDT9 DDT4L_BOVIN 100.000 0.989691 1.00518 DDIT4L - DNA damage-inducible transcript 4-like protein - Bos taurus (Bovine) - DDIT4L gene Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Taurus_UMD|evm.model.AC_000163.1.148 Q6YNC8 H2AZ_SHEEP 100.000 0.4 1.95312 H2AZ1 - Histone H2A.Z - Ovis aries (Sheep) - H2AZ1 gene Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). Taurus_UMD|evm.model.AC_000163.1.149 Q0IIE8 DJB14_BOVIN 100.000 0.994737 1.00264 DNAJB14 - DnaJ homolog subfamily B member 14 - Bos taurus (Bovine) - DNAJB14 gene Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear. Taurus_UMD|evm.model.AC_000163.1.150 Q17QQ1 LTOR3_BOVIN 100.000 0.984 1.00806 LAMTOR3 - Ragulator complex protein LAMTOR3 - Bos taurus (Bovine) - LAMTOR3 gene As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity). Taurus_UMD|evm.model.AC_000163.1.151 Q9UN19 DAPP1_HUMAN 95.785 0.925267 1.00357 DAPP1 - Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide - Homo sapiens (Human) - DAPP1 gene May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. Taurus_UMD|evm.model.AC_000163.1.152 D6RIA3 CD054_HUMAN 85.643 0.980822 1.01785 C4orf54 - Uncharacterized protein C4orf54 - Homo sapiens (Human) - C4orf54 gene Taurus_UMD|evm.model.AC_000163.1.153 P55156 MTP_BOVIN 100.000 0.989944 1.00902 MTTP - Microsomal triglyceride transfer protein large subunit precursor - Bos taurus (Bovine) - MTTP gene Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:8876250). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (By similarity). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity). Taurus_UMD|evm.model.AC_000163.1.154 Q3MHI8 TM10A_BOVIN 100.000 0.9941 1.00296 TRMT10A - tRNA methyltransferase 10 homolog A - Bos taurus (Bovine) - TRMT10A gene S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs. Taurus_UMD|evm.model.AC_000163.1.155 Q53FE4 CD017_HUMAN 74.167 0.994286 0.97493 C4orf17 - Uncharacterized protein C4orf17 - Homo sapiens (Human) - C4orf17 gene Taurus_UMD|evm.model.AC_000163.1.156 P40394 ADH7_HUMAN 82.812 0.62215 0.795337 ADH7 - All-trans-retinol dehydrogenase [NAD(+)] ADH7 - Homo sapiens (Human) - ADH7 gene Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid (PubMed:15369820, PubMed:16787387, PubMed:9600267). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387, PubMed:15369820). Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation (PubMed:9600267, PubMed:15369820, PubMed:16787387). Taurus_UMD|evm.model.AC_000163.1.157 P00328 ADH1S_HORSE 77.600 0.994429 0.959893 Alcohol dehydrogenase S chain - Equus caballus (Horse) Taurus_UMD|evm.model.AC_000163.1.158 Q9NY97 B3GN2_HUMAN 88.265 0.890411 0.551637 B3GNT2 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 - Homo sapiens (Human) - B3GNT2 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. Taurus_UMD|evm.model.AC_000163.1.159 P80338 ADH1_STRCA 57.471 0.95941 0.724599 ADH1 - Alcohol dehydrogenase 1 - Struthio camelus (Common ostrich) - ADH1 gene Taurus_UMD|evm.model.AC_000163.1.160 Q5R7Z8 ADH6_PONAB 79.255 0.994681 1.00267 ADH6 - Alcohol dehydrogenase 6 - Pongo abelii (Sumatran orangutan) - ADH6 gene Taurus_UMD|evm.model.AC_000163.1.161 Q10126 YSM6_CAEEL 29.341 0.861111 0.645161 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000163.1.162 Q03274 PO22_POPJA 30.400 0.668478 0.25879 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 - Popillia japonica (Japanese beetle) Taurus_UMD|evm.model.AC_000163.1.164 P08319 ADH4_HUMAN 77.273 0.750503 1.30789 ADH4 - All-trans-retinol dehydrogenase [NAD(+)] ADH4 - Homo sapiens (Human) - ADH4 gene Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Also catalyzes the reduction of benzoquinones (PubMed:10514444). Taurus_UMD|evm.model.AC_000163.1.165 Q3ZC42 ADHX_BOVIN 99.459 0.991914 0.991979 ADH5 - Alcohol dehydrogenase class-3 - Bos taurus (Bovine) - ADH5 gene Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Taurus_UMD|evm.model.AC_000163.1.166 A6QLA4 MAP1_BOVIN 94.560 0.994536 0.948187 METAP1 - Methionine aminopeptidase 1 - Bos taurus (Bovine) - METAP1 gene Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Taurus_UMD|evm.model.AC_000163.1.167 Q9N0T5 IF4E_BOVIN 99.539 0.935065 1.06452 EIF4E - Eukaryotic translation initiation factor 4E - Bos taurus (Bovine) - EIF4E gene Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (By similarity). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (By similarity). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). Taurus_UMD|evm.model.AC_000163.1.168 Q3B8Q1 DDX21_RAT 86.842 0.974138 0.148338 Ddx21 - Nucleolar RNA helicase 2 - Rattus norvegicus (Rat) - Ddx21 gene RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes. In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes. Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77'. Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases. Involved in rRNA processing. May bind to specific miRNA hairpins (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Taurus_UMD|evm.model.AC_000163.1.169 Q1JP79 ARC1A_BOVIN 86.429 0.985714 0.378378 ARPC1A - Actin-related protein 2/3 complex subunit 1A - Bos taurus (Bovine) - ARPC1A gene Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). Taurus_UMD|evm.model.AC_000163.1.170 A6H767 NP1L1_BOVIN 96.809 0.769547 0.621483 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Taurus_UMD|evm.model.AC_000163.1.171 Q17QJ5 TSN5_BOVIN 100.000 0.818471 1.17164 TSPAN5 - Tetraspanin-5 - Bos taurus (Bovine) - TSPAN5 gene Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44. Taurus_UMD|evm.model.AC_000163.1.172 P52306 GDS1_HUMAN 95.881 0.993443 1.00494 RAP1GDS1 - Rap1 GTPase-GDP dissociation stimulator 1 - Homo sapiens (Human) - RAP1GDS1 gene Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein (PubMed:1549351, PubMed:11948427). Able to promote the Ca(2+) release from the endoplasmic reticulum via both inositol trisphosphate (Ins3P) and ryanodine sensitive receptors leading to a enhanced mitochondrial Ca(2+) uptake (PubMed:24349085). Taurus_UMD|evm.model.AC_000163.1.173 Q8N412 STPG2_HUMAN 65.734 0.988722 0.579521 STPG2 - Sperm-tail PG-rich repeat-containing protein 2 - Homo sapiens (Human) - STPG2 gene Taurus_UMD|evm.model.AC_000163.1.175 Q2KI85 SMTL2_BOVIN 47.692 0.5 0.266376 SMTNL2 - Smoothelin-like protein 2 - Bos taurus (Bovine) - SMTNL2 gene filamentous actin, I band, M band, microtubule organizing center, protein phosphatase 1 binding, tropomyosin binding, actin cytoskeleton organization, positive regulation of vasoconstriction Taurus_UMD|evm.model.AC_000163.1.176 Q8NI29 FBX27_HUMAN 48.951 0.922297 1.04594 FBXO27 - F-box only protein 27 - Homo sapiens (Human) - FBXO27 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Taurus_UMD|evm.model.AC_000163.1.178 P35486 ODPA_MOUSE 88.235 0.994898 1.00513 Pdha1 - Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor - Mus musculus (Mouse) - Pdha1 gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Taurus_UMD|evm.model.AC_000163.1.179 O95185 UNC5C_HUMAN 99.495 0.860262 0.245972 UNC5C - Netrin receptor UNC5C precursor - Homo sapiens (Human) - UNC5C gene Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Taurus_UMD|evm.model.AC_000163.1.180 P36898 BMR1B_MOUSE 98.805 0.950664 1.0498 Bmpr1b - Bone morphogenetic protein receptor type-1B precursor - Mus musculus (Mouse) - Bmpr1b gene On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1. Receptor for GDF5 (PubMed:26105076, PubMed:19229295). Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149). Taurus_UMD|evm.model.AC_000163.1.181 Q96HC4 PDLI5_HUMAN 89.597 0.996644 1 PDLIM5 - PDZ and LIM domain protein 5 - Homo sapiens (Human) - PDLIM5 gene May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity). Taurus_UMD|evm.model.AC_000163.1.182 O60760 HPGDS_HUMAN 85.930 0.99 1.00503 HPGDS - Hematopoietic prostaglandin D synthase - Homo sapiens (Human) - HPGDS gene Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. Taurus_UMD|evm.model.AC_000163.1.183 E1B7X9 SMRCD_BOVIN 97.668 0.998056 1.00097 SMARCAD1 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 - Bos taurus (Bovine) - SMARCAD1 gene DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing (By similarity). Taurus_UMD|evm.model.AC_000163.1.184 Q92858 ATOH1_HUMAN 92.090 0.994334 0.997175 ATOH1 - Protein atonal homolog 1 - Homo sapiens (Human) - ATOH1 gene Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). Taurus_UMD|evm.model.AC_000163.1.185 O43424 GRID2_HUMAN 99.545 0.88664 0.245283 GRID2 - Glutamate receptor ionotropic, delta-2 precursor - Homo sapiens (Human) - GRID2 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex (PubMed:27418511). Taurus_UMD|evm.model.AC_000163.1.186 Q61625 GRID2_MOUSE 99.369 0.946108 0.331678 Grid2 - Glutamate receptor ionotropic, delta-2 precursor - Mus musculus (Mouse) - Grid2 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex. Taurus_UMD|evm.model.AC_000163.1.187 O43424 GRID2_HUMAN 98.266 0.826923 0.206554 GRID2 - Glutamate receptor ionotropic, delta-2 precursor - Homo sapiens (Human) - GRID2 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex (PubMed:27418511). Taurus_UMD|evm.model.AC_000163.1.188 O43424 GRID2_HUMAN 99.375 0.883333 0.178749 GRID2 - Glutamate receptor ionotropic, delta-2 precursor - Homo sapiens (Human) - GRID2 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex (PubMed:27418511). Taurus_UMD|evm.model.AC_000163.1.189 Q58DT1 RL7_BOVIN 95.098 0.980583 0.415323 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Taurus_UMD|evm.model.AC_000163.1.190 Q58DT1 RL7_BOVIN 96.226 0.981132 0.21371 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Taurus_UMD|evm.model.AC_000163.1.191 Q61625 GRID2_MOUSE 83.582 0.767442 0.0854022 Grid2 - Glutamate receptor ionotropic, delta-2 precursor - Mus musculus (Mouse) - Grid2 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex. Taurus_UMD|evm.model.AC_000163.1.192 P15907 SIAT1_HUMAN 79.021 0.84472 0.396552 ST6GAL1 - Beta-galactoside alpha-2,6-sialyltransferase 1 - Homo sapiens (Human) - ST6GAL1 gene Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. Taurus_UMD|evm.model.AC_000163.1.193 Q9NSD9 SYFB_HUMAN 93.241 0.993103 0.98472 FARSB - Phenylalanine--tRNA ligase beta subunit - Homo sapiens (Human) - FARSB gene cytoplasm, cytosol, membrane, phenylalanine-tRNA ligase complex, phenylalanine-tRNA ligase activity, phenylalanyl-tRNA aminoacylation, protein heterotetramerization, translation, tRNA aminoacylation for protein translation Taurus_UMD|evm.model.AC_000163.1.194 Q1RMS0 CCSE1_BOVIN 99.862 0.998617 0.973082 CCSER1 - Serine-rich coiled-coil domain-containing protein 1 - Bos taurus (Bovine) - CCSER1 gene Taurus_UMD|evm.model.AC_000163.1.195 Q13201 MMRN1_HUMAN 70.627 0.998225 0.917752 MMRN1 - Multimerin-1 precursor - Homo sapiens (Human) - MMRN1 gene Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. Taurus_UMD|evm.model.AC_000163.1.196 Q3T0G8 SYUA_BOVIN 100.000 0.985816 1.00714 SNCA - Alpha-synuclein - Bos taurus (Bovine) - SNCA gene Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity. Taurus_UMD|evm.model.AC_000163.1.197 Q6ZVF9 GRIN3_HUMAN 70.332 0.997439 1.00644 GPRIN3 - G protein-regulated inducer of neurite outgrowth 3 - Homo sapiens (Human) - GPRIN3 gene May be involved in neurite outgrowth. Taurus_UMD|evm.model.AC_000163.1.199 Q4W5G0 TIGD2_HUMAN 94.286 0.996198 1.0019 TIGD2 - Tigger transposable element-derived protein 2 - Homo sapiens (Human) - TIGD2 gene nucleus, DNA binding Taurus_UMD|evm.model.AC_000163.1.200 Q8HYW0 FA13A_BOVIN 99.855 0.688312 1.43615 FAM13A - Protein FAM13A - Bos taurus (Bovine) - FAM13A gene Taurus_UMD|evm.model.AC_000163.1.201 Q15034 HERC3_HUMAN 97.905 0.998097 1.00095 HERC3 - Probable E3 ubiquitin-protein ligase HERC3 - Homo sapiens (Human) - HERC3 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Taurus_UMD|evm.model.AC_000163.1.202 Q2T9V7 PREY_BOVIN 99.123 0.982609 1.00877 PREY - Protein preY, mitochondrial precursor - Bos taurus (Bovine) - PREY gene glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex, GPI anchor biosynthetic process Taurus_UMD|evm.model.AC_000163.1.203 Q9UII4 HERC5_HUMAN 76.091 0.968239 1.01465 HERC5 - E3 ISG15--protein ligase HERC5 - Homo sapiens (Human) - HERC5 gene Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15. Taurus_UMD|evm.model.AC_000163.1.204 Q8IVU3 HERC6_HUMAN 73.653 0.997053 0.996086 HERC6 - Probable E3 ubiquitin-protein ligase HERC6 - Homo sapiens (Human) - HERC6 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Taurus_UMD|evm.model.AC_000163.1.205 Q2PC20 PPM1K_BOVIN 100.000 0.885442 1.12634 PPM1K - Protein phosphatase 1K, mitochondrial precursor - Bos taurus (Bovine) - PPM1K gene Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. Taurus_UMD|evm.model.AC_000163.1.206 P57784 RU2A_MOUSE 97.590 0.539474 0.596078 Snrpa1 - U2 small nuclear ribonucleoprotein A' - Mus musculus (Mouse) - Snrpa1 gene Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. Taurus_UMD|evm.model.AC_000163.1.207 Q4GZT4 ABCG2_BOVIN 100.000 0.992413 1.00611 ABCG2 - Broad substrate specificity ATP-binding cassette transporter ABCG2 - Bos taurus (Bovine) - ABCG2 gene Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion (By similarity). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (By similarity). Mediates the secretion of the riboflavin and biotin vitamins into milk. Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain. It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (By similarity). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus. May play a role in early stem cell self-renewal by blocking differentiation (By similarity). Taurus_UMD|evm.model.AC_000163.1.208 Q4GZT3 PKD2_BOVIN 100.000 0.99794 1.00103 PKD2 - Polycystin-2 - Bos taurus (Bovine) - PKD2 gene Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (By similarity). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (By similarity). Together with TRPV4, forms mechano- and thermosensitive channels in cilium. PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. Detection of asymmetric nodal flow gives rise to a Ca(2+) signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality (By similarity). Taurus_UMD|evm.model.AC_000163.1.209 P31096 OSTP_BOVIN 100.000 0.817109 1.21942 SPP1 - Osteopontin precursor - Bos taurus (Bovine) - SPP1 gene Major non-collagenous bone protein that binds tightly to hydroxyapatite (Probable). Appears to form an integral part of the mineralized matrix (Probable). Probably important to cell-matrix interaction (Probable). Taurus_UMD|evm.model.AC_000163.1.210 Q9NQ76 MEPE_HUMAN 61.205 0.949458 1.05524 MEPE - Matrix extracellular phosphoglycoprotein precursor - Homo sapiens (Human) - MEPE gene Promotes renal phosphate excretion and inhibits intestinal phosphate absorption (PubMed:14962809, PubMed:19005008). Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (PubMed:18162525, PubMed:19998030, PubMed:22766095). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation (PubMed:22341070). Taurus_UMD|evm.model.AC_000163.1.211 Q28862 SIAL_BOVIN 100.000 0.993569 1.00323 IBSP - Bone sialoprotein 2 precursor - Bos taurus (Bovine) - IBSP gene Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity). Taurus_UMD|evm.model.AC_000163.1.212 P00727 AMPL_BOVIN 100.000 0.996154 1.00193 LAP3 - Cytosol aminopeptidase - Bos taurus (Bovine) - LAP3 gene Cytolosic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides (PubMed:14583094, PubMed:16519517). The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme (PubMed:16519517). For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates (PubMed:16519517). Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status (PubMed:14583094). Taurus_UMD|evm.model.AC_000163.1.213 Q2TBN4 MED28_BOVIN 98.876 0.988827 1.00562 MED28 - Mediator of RNA polymerase II transcription subunit 28 - Bos taurus (Bovine) - MED28 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways (By similarity). Taurus_UMD|evm.model.AC_000163.1.214 Q9ULE4 F184B_HUMAN 82.633 0.998134 1.01132 FAM184B - Protein FAM184B - Homo sapiens (Human) - FAM184B gene Taurus_UMD|evm.model.AC_000163.1.215 Q9NXF7 DCA16_HUMAN 96.296 0.990783 1.00463 DCAF16 - DDB1- and CUL4-associated factor 16 - Homo sapiens (Human) - DCAF16 gene Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. Taurus_UMD|evm.model.AC_000163.1.216 Q9BPX3 CND3_HUMAN 88.616 0.998037 1.00394 NCAPG - Condensin complex subunit 3 - Homo sapiens (Human) - NCAPG gene Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Taurus_UMD|evm.model.AC_000163.1.218 Q8N3X6 LCORL_HUMAN 98.077 0.138207 3.11296 LCORL - Ligand-dependent nuclear receptor corepressor-like protein - Homo sapiens (Human) - LCORL gene May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). Taurus_UMD|evm.model.AC_000163.1.219 Q01105 SET_HUMAN 53.548 0.683544 0.544828 SET - Protein SET - Homo sapiens (Human) - SET gene Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. Taurus_UMD|evm.model.AC_000163.1.222 Q8N7B6 PACRL_HUMAN 89.113 0.991968 1.00403 PACRGL - PACRG-like protein - Homo sapiens (Human) - PACRGL gene Taurus_UMD|evm.model.AC_000163.1.223 Q2KI69 KCIP4_BOVIN 100.000 0.989796 0.784 KCNIP4 - Kv channel-interacting protein 4 - Bos taurus (Bovine) - KCNIP4 gene Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents (By similarity). Taurus_UMD|evm.model.AC_000163.1.225 P62907 RL10A_RAT 64.463 0.978261 0.423963 Rpl10a - 60S ribosomal protein L10a - Rattus norvegicus (Rat) - Rpl10a gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000163.1.226 Q8IWK6 AGRA3_HUMAN 96.113 0.986411 0.94701 ADGRA3 - Adhesion G protein-coupled receptor A3 precursor - Homo sapiens (Human) - ADGRA3 gene Orphan receptor that may have a role in planar cell polarity pathway. Taurus_UMD|evm.model.AC_000163.1.227 Q9H227 GBA3_HUMAN 87.794 0.806228 1.23241 GBA3 - Cytosolic beta-glucosidase - Homo sapiens (Human) - GBA3 gene Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides (PubMed:11389701, PubMed:11784319, PubMed:20728381, PubMed:26724485, PubMed:17595169). Has a significant glucosylceramidase activity in vitro (PubMed:26724485, PubMed:17595169). However, that activity is relatively low and its significance in vivo is not clear (PubMed:26724485, PubMed:17595169, PubMed:20728381). Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph (PubMed:17595169). However, the in vivo relevance of these activities is unclear (PubMed:17595169). It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics (PubMed:11784319). Could also play a role in the catabolism of cytosolic sialyl free N-glycans (PubMed:26193330). Taurus_UMD|evm.model.AC_000163.1.228 P08548 LIN1_NYCCO 36.782 0.611511 0.110317 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Taurus_UMD|evm.model.AC_000163.1.230 Q5RCP8 H2B2E_PONAB 88.496 0.982456 0.904762 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000163.1.231 Q865B7 PRGC1_BOVIN 100.000 0.976658 1.02261 PPARGC1A - Peroxisome proliferator-activated receptor gamma coactivator 1-alpha - Bos taurus (Bovine) - PPARGC1A gene Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity). Taurus_UMD|evm.model.AC_000163.1.234 O43143 DHX15_HUMAN 99.748 0.997487 1.00126 DHX15 - Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 - Homo sapiens (Human) - DHX15 gene Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. Taurus_UMD|evm.model.AC_000163.1.235 Q90YR8 RS6_ICTPU 77.551 0.623377 0.309237 rps6 - 40S ribosomal protein S6 - Ictalurus punctatus (Channel catfish) - rps6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Taurus_UMD|evm.model.AC_000163.1.236 P08294 SODE_HUMAN 78.605 0.764286 1.16667 SOD3 - Extracellular superoxide dismutase [Cu-Zn] precursor - Homo sapiens (Human) - SOD3 gene Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. Taurus_UMD|evm.model.AC_000163.1.237 Q0VCP9 CC149_BOVIN 83.276 0.510504 1.49216 CCDC149 - Coiled-coil domain-containing protein 149 - Bos taurus (Bovine) - CCDC149 gene Taurus_UMD|evm.model.AC_000163.1.238 Q1EGL1 LGI2_PANTR 97.248 0.996337 1.00183 LGI2 - Leucine-rich repeat LGI family member 2 precursor - Pan troglodytes (Chimpanzee) - LGI2 gene Required for the development of soma-targeting inhibitory GABAergic synapses made by parvalbumin-positive basket cells. Taurus_UMD|evm.model.AC_000163.1.239 Q9HD40 SPCS_HUMAN 94.534 0.878788 1.11976 SEPSECS - O-phosphoseryl-tRNA(Sec) selenium transferase - Homo sapiens (Human) - SEPSECS gene Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. Taurus_UMD|evm.model.AC_000163.1.240 Q5ZIK0 P4K2B_CHICK 81.088 0.784836 1.01879 PI4K2B - Phosphatidylinositol 4-kinase type 2-beta - Gallus gallus (Chicken) - PI4K2B gene Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity). Taurus_UMD|evm.model.AC_000163.1.241 E1BGQ2 ZCHC4_BOVIN 99.419 0.996109 0.996124 ZCCHC4 - rRNA N6-adenosine-methyltransferase ZCCHC4 - Bos taurus (Bovine) - ZCCHC4 gene rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation. Taurus_UMD|evm.model.AC_000163.1.242 Q9UJX5 APC4_HUMAN 97.153 0.997528 1.00124 ANAPC4 - Anaphase-promoting complex subunit 4 - Homo sapiens (Human) - ANAPC4 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Taurus_UMD|evm.model.AC_000163.1.243 Q27960 NPT2B_BOVIN 99.423 0.985755 1.01299 SLC34A2 - Sodium-dependent phosphate transport protein 2B - Bos taurus (Bovine) - SLC34A2 gene May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli (By similarity). Taurus_UMD|evm.model.AC_000163.1.244 Q68CR1 SE1L3_HUMAN 91.931 0.997959 0.865724 SEL1L3 - Protein sel-1 homolog 3 - Homo sapiens (Human) - SEL1L3 gene nucleoplasm Taurus_UMD|evm.model.AC_000163.1.245 Q8N5G0 SIM20_HUMAN 98.214 0.376712 2.1791 SMIM20 - Small integral membrane protein 20 - Homo sapiens (Human) - SMIM20 gene Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (PubMed:26321642). Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C (PubMed:26321642). Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover (PubMed:26321642). Taurus_UMD|evm.model.AC_000163.1.246 Q3SZ41 SUH_BOVIN 100.000 0.995902 1.00205 RBPJ - Recombining binding protein suppressor of hairless - Bos taurus (Bovine) - RBPJ gene Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity). Taurus_UMD|evm.model.AC_000163.1.247 P32238 CCKAR_HUMAN 91.335 0.993007 1.00234 CCKAR - Cholecystokinin receptor type A - Homo sapiens (Human) - CCKAR gene Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000163.1.248 Q8N5T2 TBC19_HUMAN 87.262 0.995745 0.893536 TBC1D19 - TBC1 domain family member 19 - Homo sapiens (Human) - TBC1D19 gene May act as a GTPase-activating protein for Rab family protein(s). Taurus_UMD|evm.model.AC_000163.1.249 Q9P246 STIM2_HUMAN 95.060 0.894737 1.12064 STIM2 - Stromal interaction molecule 2 precursor - Homo sapiens (Human) - STIM2 gene Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. Taurus_UMD|evm.model.AC_000163.1.251 Q3SZ63 NOP56_BOVIN 74.757 0.61875 0.268456 NOP56 - Nucleolar protein 56 - Bos taurus (Bovine) - NOP56 gene Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). Taurus_UMD|evm.model.AC_000163.1.253 A6H767 NP1L1_BOVIN 60.550 0.643411 0.329923 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Taurus_UMD|evm.model.AC_000163.1.255 A8D8X1 RL10_SHEEP 72.222 0.972727 0.514019 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000163.1.256 O60245 PCDH7_HUMAN 97.736 0.841812 1.1768 PCDH7 - Protocadherin-7 precursor - Homo sapiens (Human) - PCDH7 gene integral component of plasma membrane, plasma membrane, platelet alpha granule membrane, cell adhesion, platelet degranulation Taurus_UMD|evm.model.AC_000163.1.257 Q13310 PABP4_HUMAN 72.952 0.955479 0.906832 PABPC4 - Polyadenylate-binding protein 4 - Homo sapiens (Human) - PABPC4 gene Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). Taurus_UMD|evm.model.AC_000163.1.258 Q2KIJ6 UBXN6_BOVIN 65.306 0.383929 0.253968 UBXN6 - UBX domain-containing protein 6 - Bos taurus (Bovine) - UBXN6 gene May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Taurus_UMD|evm.model.AC_000163.1.260 P60509 ERB1_HUMAN 38.017 0.930233 0.250973 ERVPABLB-1 - Endogenous retrovirus group PABLB member 1 Env polyprotein - Homo sapiens (Human) - ERVPABLB-1 gene Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. Taurus_UMD|evm.model.AC_000163.1.263 Q8WZ64 ARAP2_HUMAN 80.803 0.996381 0.973005 ARAP2 - Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 - Homo sapiens (Human) - ARAP2 gene Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity). Taurus_UMD|evm.model.AC_000163.1.265 Q6ZMT9 DTHD1_HUMAN 73.130 0.927245 0.827145 DTHD1 - Death domain-containing protein 1 - Homo sapiens (Human) - DTHD1 gene Taurus_UMD|evm.model.AC_000163.1.266 Q9Y605 MOFA1_HUMAN 48.193 0.413613 1.50394 MRFAP1 - MORF4 family-associated protein 1 - Homo sapiens (Human) - MRFAP1 gene nucleoplasm Taurus_UMD|evm.model.AC_000163.1.267 Q6ZMT9 DTHD1_HUMAN 85.849 0.820312 0.163892 DTHD1 - Death domain-containing protein 1 - Homo sapiens (Human) - DTHD1 gene Taurus_UMD|evm.model.AC_000163.1.268 P10854 H2B1M_MOUSE 92.593 0.981651 0.865079 H2bc14 - Histone H2B type 1-M - Mus musculus (Mouse) - H2bc14 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000163.1.269 Q6P5U7 NWD2_MOUSE 100.000 0.510417 0.0551091 Nwd2 - NACHT and WD repeat domain-containing protein 2 - Mus musculus (Mouse) - Nwd2 gene Taurus_UMD|evm.model.AC_000163.1.270 Q9ULI1 NWD2_HUMAN 95.751 0.991667 0.964409 NWD2 - NACHT and WD repeat domain-containing protein 2 - Homo sapiens (Human) - NWD2 gene Taurus_UMD|evm.model.AC_000163.1.271 Q7T326 CISD2_DANRE 77.419 0.535714 0.414815 cisd2 - CDGSH iron-sulfur domain-containing protein 2 - Danio rerio (Zebrafish) - cisd2 gene Regulator of autophagy that contributes to antagonize becn1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of bcl2 with becn1 and is required for bcl2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy (By similarity). Taurus_UMD|evm.model.AC_000163.1.272 Q8IY42 CD019_HUMAN 59.502 0.993789 1.02548 C4orf19 - Uncharacterized protein C4orf19 - Homo sapiens (Human) - C4orf19 gene cell junction, nucleoplasm Taurus_UMD|evm.model.AC_000163.1.273 Q08DP3 RELL1_BOVIN 100.000 0.992647 1.00369 RELL1 - RELT-like protein 1 precursor - Bos taurus (Bovine) - RELL1 gene Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed. Taurus_UMD|evm.model.AC_000163.1.274 Q5U1W4 LAP4B_RAT 76.154 0.976562 0.563877 Laptm4b - Lysosomal-associated transmembrane protein 4B - Rattus norvegicus (Rat) - Laptm4b gene Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways. Taurus_UMD|evm.model.AC_000163.1.275 Q96G03 PGM2_HUMAN 91.348 0.995025 0.985294 PGM2 - Phosphoglucomutase-2 - Homo sapiens (Human) - PGM2 gene Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity. Taurus_UMD|evm.model.AC_000163.1.277 O97790 TBCD1_BOVIN 100.000 0.501587 1.08155 TBC1D1 - TBC1 domain family member 1 - Bos taurus (Bovine) - TBC1D1 gene May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). Taurus_UMD|evm.model.AC_000163.1.278 P57682 KLF3_HUMAN 97.110 0.994236 1.0058 KLF3 - Krueppel-like factor 3 - Homo sapiens (Human) - KLF3 gene Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). Taurus_UMD|evm.model.AC_000163.1.279 Q6GV17 TLR10_BOVIN 100.000 0.997426 0.956897 TLR10 - Toll-like receptor 10 precursor - Bos taurus (Bovine) - TLR10 gene Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Taurus_UMD|evm.model.AC_000163.1.280 Q15399 TLR1_HUMAN 78.344 0.988651 1.00891 TLR1 - Toll-like receptor 1 precursor - Homo sapiens (Human) - TLR1 gene Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Taurus_UMD|evm.model.AC_000163.1.281 Q704V6 TLR6_BOVIN 98.089 0.983689 1.00504 TLR6 - Toll-like receptor 6 precursor - Bos taurus (Bovine) - TLR6 gene Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Taurus_UMD|evm.model.AC_000163.1.282 Q8IWE2 NXP20_HUMAN 84.369 0.903537 1.1048 FAM114A1 - Protein NOXP20 - Homo sapiens (Human) - FAM114A1 gene May play a role in neuronal cell development. Taurus_UMD|evm.model.AC_000163.1.283 Q8N614 TM156_HUMAN 73.649 0.740554 1.34122 TMEM156 - Transmembrane protein 156 - Homo sapiens (Human) - TMEM156 gene Taurus_UMD|evm.model.AC_000163.1.284 Q96PQ7 KLHL5_HUMAN 98.872 0.997183 0.940397 KLHL5 - Kelch-like protein 5 - Homo sapiens (Human) - KLHL5 gene cytoplasm, cytosol, post-translational protein modification Taurus_UMD|evm.model.AC_000163.1.285 Q8NEZ3 WDR19_HUMAN 91.424 0.997766 1.00075 WDR19 - WD repeat-containing protein 19 - Homo sapiens (Human) - WDR19 gene As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in cilia function and/or assembly (PubMed:20889716). Essential for functional IFT-A assembly and ciliary entry of GPCRs (PubMed:20889716). Associates with the BBSome complex to mediate ciliary transport (By similarity). Taurus_UMD|evm.model.AC_000163.1.286 P35251 RFC1_HUMAN 82.240 0.990018 0.95993 RFC1 - Replication factor C subunit 1 - Homo sapiens (Human) - RFC1 gene The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA. Taurus_UMD|evm.model.AC_000163.1.287 Q86Z14 KLOTB_HUMAN 91.463 0.290284 0.808429 KLB - Beta-klotho - Homo sapiens (Human) - KLB gene Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity). Taurus_UMD|evm.model.AC_000163.1.288 Q3SYR7 RL9_BOVIN 100.000 0.989637 1.00521 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000163.1.289 Q5BIP7 LIAS_BOVIN 100.000 0.994638 1.00269 LIAS - Lipoyl synthase, mitochondrial precursor - Bos taurus (Bovine) - LIAS gene Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. Taurus_UMD|evm.model.AC_000163.1.290 P12378 UGDH_BOVIN 100.000 0.99596 1.00202 UGDH - UDP-glucose 6-dehydrogenase - Bos taurus (Bovine) - UGDH gene Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (By similarity). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (By similarity). Taurus_UMD|evm.model.AC_000163.1.291 Q91VT8 SIM14_MOUSE 100.000 0.27907 0.868687 Smim14 - Small integral membrane protein 14 - Mus musculus (Mouse) - Smim14 gene endoplasmic reticulum, blastocyst hatching Taurus_UMD|evm.model.AC_000163.1.294 P61087 UBE2K_MOUSE 100.000 0.988889 0.9 Ube2k - Ubiquitin-conjugating enzyme E2 K - Mus musculus (Mouse) - Ube2k gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. Involved in stabilization of CASP12 during ER stress-mediated amyloid-beta neurotoxicity probably by inhibiting proteasome activity; in vitro ubiquitinates CASP12. Taurus_UMD|evm.model.AC_000163.1.295 Q29RF7 PDS5A_HUMAN 91.648 0.998466 0.975318 PDS5A - Sister chromatid cohesion protein PDS5 homolog A - Homo sapiens (Human) - PDS5A gene Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Taurus_UMD|evm.model.AC_000163.1.297 Q86UW6 N4BP2_HUMAN 80.506 0.998869 0.99887 N4BP2 - NEDD4-binding protein 2 - Homo sapiens (Human) - N4BP2 gene Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. Taurus_UMD|evm.model.AC_000163.1.298 Q2HJG3 RHOH_BOVIN 99.476 0.989583 1.00524 RHOH - Rho-related GTP-binding protein RhoH precursor - Bos taurus (Bovine) - RHOH gene Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils. Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells. Taurus_UMD|evm.model.AC_000163.1.299 Q9UGM1 ACHA9_HUMAN 94.363 0.995833 1.00209 CHRNA9 - Neuronal acetylcholine receptor subunit alpha-9 precursor - Homo sapiens (Human) - CHRNA9 gene Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840). Taurus_UMD|evm.model.AC_000163.1.300 A0AV96 RBM47_HUMAN 97.143 0.996622 0.998314 RBM47 - RNA-binding protein 47 - Homo sapiens (Human) - RBM47 gene nucleus, mRNA binding, RNA binding Taurus_UMD|evm.model.AC_000163.1.301 Q8NE18 NSUN7_HUMAN 80.194 0.995845 1.00557 NSUN7 - Putative methyltransferase NSUN7 - Homo sapiens (Human) - NSUN7 gene May have S-adenosyl-L-methionine-dependent methyl-transferase activity. Taurus_UMD|evm.model.AC_000163.1.302 Q92870 APBB2_HUMAN 94.071 0.997361 1 APBB2 - Amyloid-beta A4 precursor protein-binding family B member 2 - Homo sapiens (Human) - APBB2 gene May modulate the internalization of amyloid-beta precursor protein. Taurus_UMD|evm.model.AC_000163.1.304 Q6SEG5 UCHL1_PIG 98.655 0.991071 1.00448 UCHL1 - Ubiquitin carboxyl-terminal hydrolase isozyme L1 precursor - Sus scrofa (Pig) - UCHL1 gene Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity). Taurus_UMD|evm.model.AC_000163.1.306 O35690 PHX2B_MOUSE 99.048 0.993671 1.00637 Phox2b - Paired mesoderm homeobox protein 2B - Mus musculus (Mouse) - Phox2b gene chromatin, nucleoplasm, nucleus, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, autonomic nervous system development, cell development Taurus_UMD|evm.model.AC_000163.1.309 P57088 TMM33_HUMAN 96.748 0.987903 1.00405 TMEM33 - Transmembrane protein 33 - Homo sapiens (Human) - TMEM33 gene Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696). Taurus_UMD|evm.model.AC_000163.1.310 Q6PML9 ZNT9_HUMAN 93.695 0.996473 0.998239 SLC30A9 - Zinc transporter 9 - Homo sapiens (Human) - SLC30A9 gene Acts as a zinc transporter involved in intracellular zinc homeostasis (PubMed:28334855). Functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes (By similarity). Taurus_UMD|evm.model.AC_000163.1.311 Q6ZU67 BEND4_HUMAN 91.481 0.996283 1.00749 BEND4 - BEN domain-containing protein 4 - Homo sapiens (Human) - BEND4 gene Taurus_UMD|evm.model.AC_000163.1.312 A0PJX4 SHSA3_HUMAN 95.982 0.933054 1.0042 SHISA3 - Protein shisa-3 homolog precursor - Homo sapiens (Human) - SHISA3 gene Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Taurus_UMD|evm.model.AC_000163.1.313 Q29449 AT8A1_BOVIN 88.693 0.998064 0.899043 ATP8A1 - Probable phospholipid-transporting ATPase IA - Bos taurus (Bovine) - ATP8A1 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (By similarity). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (By similarity). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane (By similarity). Acts as aminophospholipid translocase at the plasma membrane in neuronal cells (By similarity). Taurus_UMD|evm.model.AC_000163.1.315 Q5RB63 HTSF1_PONAB 77.778 0.9875 0.530504 HTATSF1 - HIV Tat-specific factor 1 homolog - Pongo abelii (Sumatran orangutan) - HTATSF1 gene Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation (By similarity). Taurus_UMD|evm.model.AC_000163.1.316 A8MXD5 GRCR1_HUMAN 89.922 0.842105 0.524138 GRXCR1 - Glutaredoxin domain-containing cysteine-rich protein 1 - Homo sapiens (Human) - GRXCR1 gene May play a role in actin filament architecture in developing stereocilia of sensory cells. Taurus_UMD|evm.model.AC_000163.1.317 Q50H32 GRCR1_MOUSE 96.226 0.853659 0.424138 Grxcr1 - Glutaredoxin domain-containing cysteine-rich protein 1 - Mus musculus (Mouse) - Grxcr1 gene May play a role in actin filament architecture in developing stereocilia of sensory cells. Taurus_UMD|evm.model.AC_000163.1.319 Q9BUJ2 HNRL1_HUMAN 85.795 0.988701 0.206776 HNRNPUL1 - Heterogeneous nuclear ribonucleoprotein U-like protein 1 - Homo sapiens (Human) - HNRNPUL1 gene Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. Taurus_UMD|evm.model.AC_000163.1.321 Q6ZWB6 KCTD8_HUMAN 96.795 0.922619 0.35518 KCTD8 - BTB/POZ domain-containing protein KCTD8 - Homo sapiens (Human) - KCTD8 gene Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). Taurus_UMD|evm.model.AC_000163.1.322 Q6ZWB6 KCTD8_HUMAN 95.950 0.960606 0.697674 KCTD8 - BTB/POZ domain-containing protein KCTD8 - Homo sapiens (Human) - KCTD8 gene Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). Taurus_UMD|evm.model.AC_000163.1.323 A5D7K7 YIPF7_BOVIN 95.686 0.99187 0.964706 YIPF7 - Protein YIPF7 - Bos taurus (Bovine) - YIPF7 gene Taurus_UMD|evm.model.AC_000163.1.324 A6QLJ3 GUF1_BOVIN 100.000 0.889481 1.12257 GUF1 - Translation factor GUF1, mitochondrial precursor - Bos taurus (Bovine) - GUF1 gene Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. Taurus_UMD|evm.model.AC_000163.1.325 Q17QL1 GNPI2_BOVIN 100.000 0.804094 1.23913 GNPDA2 - Glucosamine-6-phosphate isomerase 2 - Bos taurus (Bovine) - GNPDA2 gene cytoplasm, glucosamine-6-phosphate deaminase activity, identical protein binding, glucosamine catabolic process, N-acetylglucosamine catabolic process, N-acetylneuraminate catabolic process, UDP-N-acetylglucosamine biosynthetic process Taurus_UMD|evm.model.AC_000163.1.326 O35066 KIF3C_MOUSE 61.224 0.505263 0.119347 Kif3c - Kinesin-like protein KIF3C - Mus musculus (Mouse) - Kif3c gene Microtubule-based anterograde translocator for membranous organelles. Taurus_UMD|evm.model.AC_000163.1.327 Q9R0Y8 GBRG1_MOUSE 95.745 0.99734 0.808602 Gabrg1 - Gamma-aminobutyric acid receptor subunit gamma-1 precursor - Mus musculus (Mouse) - Gabrg1 gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Taurus_UMD|evm.model.AC_000163.1.328 Q5RCC5 GBRA2_PONAB 100.000 0.988636 0.585366 GABRA2 - Gamma-aminobutyric acid receptor subunit alpha-2 precursor - Pongo abelii (Sumatran orangutan) - GABRA2 gene Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Taurus_UMD|evm.model.AC_000163.1.329 Q6WV90 H4_MYTGA 98.969 0.780488 1.19417 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000163.1.330 P20237 GBRA4_BOVIN 96.577 0.99631 0.976577 GABRA4 - Gamma-aminobutyric acid receptor subunit alpha-4 precursor - Bos taurus (Bovine) - GABRA4 gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Taurus_UMD|evm.model.AC_000163.1.332 P08220 GBRB1_BOVIN 97.885 0.955621 0.71308 GABRB1 - Gamma-aminobutyric acid receptor subunit beta-1 precursor - Bos taurus (Bovine) - GABRB1 gene Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. Taurus_UMD|evm.model.AC_000163.1.333 Q9NX08 COMD8_HUMAN 83.607 0.98913 1.00546 COMMD8 - COMM domain-containing protein 8 - Homo sapiens (Human) - COMMD8 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Taurus_UMD|evm.model.AC_000163.1.334 Q9P241 AT10D_HUMAN 85.317 0.990991 1.01192 ATP10D - Phospholipid-transporting ATPase VD - Homo sapiens (Human) - ATP10D gene Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane. Taurus_UMD|evm.model.AC_000163.1.335 Q9Y5Q5 CORIN_HUMAN 78.947 0.994692 0.904031 CORIN - Atrial natriuretic peptide-converting enzyme - Homo sapiens (Human) - CORIN gene Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:21288900, PubMed:20489134, PubMed:21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed:10880574, PubMed:21288900, PubMed:20489134, PubMed:21763278). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503). Also acts as a regulator of sodium reabsorption in kidney (By similarity). Taurus_UMD|evm.model.AC_000163.1.336 Q6ZNB6 NFXL1_HUMAN 93.115 0.997817 1.00549 NFXL1 - NF-X1-type zinc finger protein NFXL1 - Homo sapiens (Human) - NFXL1 gene chromatin, membrane, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, regulation of transcription, DNA-templated Taurus_UMD|evm.model.AC_000163.1.337 Q00194 CNGA1_BOVIN 100.000 0.997106 1.00145 CNGA1 - cGMP-gated cation channel alpha-1 - Bos taurus (Bovine) - CNGA1 gene Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. Taurus_UMD|evm.model.AC_000163.1.338 Q6NVV3 NIPA3_HUMAN 88.235 0.985472 1.00732 NIPAL1 - Magnesium transporter NIPA3 - Homo sapiens (Human) - NIPAL1 gene Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). Taurus_UMD|evm.model.AC_000163.1.339 P42681 TXK_HUMAN 88.805 0.996212 1.0019 TXK - Tyrosine-protein kinase TXK - Homo sapiens (Human) - TXK gene Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 (PubMed:11859127, PubMed:17177976). Within the complex, phosphorylates both PARP1 and EEF1A1 (PubMed:17177976). Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. Taurus_UMD|evm.model.AC_000163.1.340 P42680 TEC_HUMAN 93.185 0.788462 1.23613 TEC - Tyrosine-protein kinase Tec - Homo sapiens (Human) - TEC gene Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation. Taurus_UMD|evm.model.AC_000163.1.341 Q3MHV6 SLAI2_BOVIN 100.000 0.907816 0.857388 SLAIN2 - SLAIN motif-containing protein 2 - Bos taurus (Bovine) - SLAIN2 gene Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase (By similarity). Taurus_UMD|evm.model.AC_000163.1.342 Q96EP9 NTCP4_HUMAN 86.041 0.971047 1.02746 SLC10A4 - Sodium/bile acid cotransporter 4 - Homo sapiens (Human) - SLC10A4 gene Transporter for bile acids. Taurus_UMD|evm.model.AC_000163.1.343 Q1XFL1 ZAR1L_BOVIN 65.385 0.217647 1.06918 ZAR1L - ZAR1-like protein - Bos taurus (Bovine) - ZAR1L gene cytoplasm, mRNA binding involved in posttranscriptional gene silencing, translation Taurus_UMD|evm.model.AC_000163.1.344 O94915 FRYL_HUMAN 95.353 0.992686 0.998341 FRYL - Protein furry homolog-like - Homo sapiens (Human) - FRYL gene Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. Taurus_UMD|evm.model.AC_000163.1.345 Q5E948 OCAD1_BOVIN 99.595 0.991935 1.00405 Ociad1 - OCIA domain-containing protein 1 - Bos taurus (Bovine) - Ociad1 gene Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Taurus_UMD|evm.model.AC_000163.1.346 Q3SYY7 OCAD2_BOVIN 100.000 0.987097 1.00649 OCIAD2 - OCIA domain-containing protein 2 - Bos taurus (Bovine) - OCIAD2 gene Taurus_UMD|evm.model.AC_000163.1.347 Q9H720 PG2IP_HUMAN 85.408 0.997143 1.00143 CWH43 - PGAP2-interacting protein - Homo sapiens (Human) - CWH43 gene Involved in lipid remodeling during GPI-anchor maturation. Taurus_UMD|evm.model.AC_000163.1.349 Q92564 DCNL4_HUMAN 98.973 0.993174 1.00342 DCUN1D4 - DCN1-like protein 4 - Homo sapiens (Human) - DCUN1D4 gene Contributes to the neddylation of all cullins by transfering NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which are necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). Taurus_UMD|evm.model.AC_000163.1.350 Q68CR7 LRC66_HUMAN 55.916 0.994033 0.952273 LRRC66 - Leucine-rich repeat-containing protein 66 - Homo sapiens (Human) - LRRC66 gene Taurus_UMD|evm.model.AC_000163.1.351 A6QP70 SGCB_BOVIN 100.000 0.993711 1.00315 SGCB - Beta-sarcoglycan - Bos taurus (Bovine) - SGCB gene Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Taurus_UMD|evm.model.AC_000163.1.352 E1BLK7 MIEAP_BOVIN 96.409 0.996416 1.03911 SPATA18 - Mitochondria-eating protein - Bos taurus (Bovine) - SPATA18 gene Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Taurus_UMD|evm.model.AC_000163.1.353 Q5RBQ4 UBP46_PONAB 100.000 0.99455 1.00273 USP46 - Ubiquitin carboxyl-terminal hydrolase 46 - Pongo abelii (Sumatran orangutan) - USP46 gene Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2 (By similarity). Taurus_UMD|evm.model.AC_000163.1.354 Q5E9J3 RSLBB_BOVIN 100.000 0.991968 1.00403 RASL11B - Ras-like protein family member 11B - Bos taurus (Bovine) - RASL11B gene Taurus_UMD|evm.model.AC_000163.1.355 Q8WU76 SCFD2_HUMAN 87.920 0.998471 0.95614 SCFD2 - Sec1 family domain-containing protein 2 - Homo sapiens (Human) - SCFD2 gene May be involved in protein transport. Taurus_UMD|evm.model.AC_000163.1.356 Q5RAA7 FIP1_PONAB 92.308 0.553971 0.835034 FIP1L1 - Pre-mRNA 3'-end-processing factor FIP1 - Pongo abelii (Sumatran orangutan) - FIP1L1 gene Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity). Taurus_UMD|evm.model.AC_000163.1.357 Q8TBB1 LNX1_HUMAN 87.993 0.958861 0.868132 LNX1 - E3 ubiquitin-protein ligase LNX - Homo sapiens (Human) - LNX1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Taurus_UMD|evm.model.AC_000163.1.358 O70263 LNX1_MOUSE 93.846 0.977273 0.181319 Lnx1 - E3 ubiquitin-protein ligase LNX - Mus musculus (Mouse) - Lnx1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Taurus_UMD|evm.model.AC_000163.1.359 Q5R4N5 UFM1_PONAB 100.000 0.628099 1.42353 UFM1 - Ubiquitin-fold modifier 1 precursor - Pongo abelii (Sumatran orangutan) - UFM1 gene Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription. Taurus_UMD|evm.model.AC_000163.1.360 Q9UKJ5 CHIC2_HUMAN 100.000 0.987952 1.00606 CHIC2 - Cysteine-rich hydrophobic domain-containing protein 2 - Homo sapiens (Human) - CHIC2 gene Golgi-associated vesicle, intracellular membrane-bounded organelle, plasma membrane Taurus_UMD|evm.model.AC_000163.1.361 Q9BZM3 GSX2_HUMAN 92.787 0.826087 1.21053 GSX2 - GS homeobox 2 - Homo sapiens (Human) - GSX2 gene Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development (PubMed:31412107). During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity). Taurus_UMD|evm.model.AC_000163.1.362 P16234 PGFRA_HUMAN 94.123 0.998165 1.00092 PDGFRA - Platelet-derived growth factor receptor alpha precursor - Homo sapiens (Human) - PDGFRA gene Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. Taurus_UMD|evm.model.AC_000163.1.363 P43481 KIT_BOVIN 99.591 0.997947 0.996929 KIT - Mast/stem cell growth factor receptor Kit precursor - Bos taurus (Bovine) - KIT gene Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity). Taurus_UMD|evm.model.AC_000163.1.364 P35968 VGFR2_HUMAN 91.077 0.998526 1.00074 KDR - Vascular endothelial growth factor receptor 2 precursor - Homo sapiens (Human) - KDR gene Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. Taurus_UMD|evm.model.AC_000163.1.365 D2HBV9 PORED_AILME 95.349 0.408654 0.654088 SRD5A3 - Polyprenol reductase - Ailuropoda melanoleuca (Giant panda) - SRD5A3 gene Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (By similarity). Taurus_UMD|evm.model.AC_000163.1.366 Q9HC07 TM165_HUMAN 95.370 0.993846 1.00309 TMEM165 - Transmembrane protein 165 precursor - Homo sapiens (Human) - TMEM165 gene May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation. Taurus_UMD|evm.model.AC_000163.1.367 O15516 CLOCK_HUMAN 96.930 0.997636 1 CLOCK - Circadian locomoter output cycles protein kaput - Homo sapiens (Human) - CLOCK gene Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner ARNTL/BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). Taurus_UMD|evm.model.AC_000163.1.368 Q32LN3 PDCL2_BOVIN 100.000 0.483936 2.05785 PDCL2 - Phosducin-like protein 2 - Bos taurus (Bovine) - PDCL2 gene Taurus_UMD|evm.model.AC_000163.1.369 P60982 DEST_PIG 86.567 0.90411 0.442424 DSTN - Destrin - Sus scrofa (Pig) - DSTN gene Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. Taurus_UMD|evm.model.AC_000163.1.372 Q9NV70 EXOC1_HUMAN 98.658 0.997765 1.00112 EXOC1 - Exocyst complex component 1 - Homo sapiens (Human) - EXOC1 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Taurus_UMD|evm.model.AC_000163.1.373 Q66GS9 CP135_HUMAN 88.147 0.998246 1 CEP135 - Centrosomal protein of 135 kDa - Homo sapiens (Human) - CEP135 gene Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). Taurus_UMD|evm.model.AC_000163.1.374 Q5PR69 CRACD_MOUSE 83.142 0.176991 1.21707 Cracd - Capping protein-inhibiting regulator of actin dynamics - Mus musculus (Mouse) - Cracd gene Involved in epithelial cell integrity by acting on the dynamics of the actin cytoskeleton (PubMed:30361697). Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin (By similarity). Taurus_UMD|evm.model.AC_000163.1.375 Q4L235 ACSF4_HUMAN 83.636 0.969109 1.03188 AASDH - Beta-alanine-activating enzyme - Homo sapiens (Human) - AASDH gene Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA. Taurus_UMD|evm.model.AC_000163.1.376 Q06203 PUR1_HUMAN 88.819 0.995781 0.916828 PPAT - Amidophosphoribosyltransferase precursor - Homo sapiens (Human) - PPAT gene cytosol, amidophosphoribosyltransferase activity, purine nucleotide biosynthetic process, purine ribonucleoside monophosphate biosynthetic process Taurus_UMD|evm.model.AC_000163.1.377 Q5RB59 PUR6_PONAB 94.824 0.490173 2.03529 PAICS - Multifunctional protein ADE2 - Pongo abelii (Sumatran orangutan) - PAICS gene Taurus_UMD|evm.model.AC_000163.1.378 P33731 SRP72_CANLF 97.914 0.997024 1.00149 SRP72 - Signal recognition particle subunit SRP72 - Canis lupus familiaris (Dog) - SRP72 gene Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. Taurus_UMD|evm.model.AC_000163.1.379 Q6T311 ARL9_HUMAN 85.795 0.553797 1.68984 ARL9 - ADP-ribosylation factor-like protein 9 - Homo sapiens (Human) - ARL9 gene Taurus_UMD|evm.model.AC_000163.1.380 Q5PQR6 THEGL_RAT 66.261 0.713974 1.00881 Thegl - Testicular haploid expressed gene protein-like - Rattus norvegicus (Rat) - Thegl gene Taurus_UMD|evm.model.AC_000163.1.381 P62282 RS11_RAT 72.152 0.742857 1.32911 Rps11 - 40S ribosomal protein S11 - Rattus norvegicus (Rat) - Rps11 gene cytosolic small ribosomal subunit, membrane, structural constituent of ribosome, osteoblast differentiation Taurus_UMD|evm.model.AC_000163.1.382 P20155 ISK2_HUMAN 77.049 0.705882 1.0119 SPINK2 - Serine protease inhibitor Kazal-type 2 precursor - Homo sapiens (Human) - SPINK2 gene As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin. Taurus_UMD|evm.model.AC_000163.1.383 Q13127 REST_HUMAN 70.354 0.948669 0.958979 REST - RE1-silencing transcription factor - Homo sapiens (Human) - REST gene Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247, PubMed:11741002, PubMed:11779185). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). Taurus_UMD|evm.model.AC_000163.1.384 Q32LB9 NOA1_BOVIN 71.204 0.873016 0.272334 NOA1 - Nitric oxide-associated protein 1 - Bos taurus (Bovine) - NOA1 gene Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP (By similarity). Taurus_UMD|evm.model.AC_000163.1.386 P20155 ISK2_HUMAN 70.000 0.544444 1.07143 SPINK2 - Serine protease inhibitor Kazal-type 2 precursor - Homo sapiens (Human) - SPINK2 gene As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin. Taurus_UMD|evm.model.AC_000163.1.387 O54963 REST_RAT 65.654 0.897138 1.04584 Rest - RE1-silencing transcription factor - Rattus norvegicus (Rat) - Rest gene Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (By similarity). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (By similarity). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (PubMed:9454838). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (By similarity). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 6 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 6, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (By similarity). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult hippocampal neural stem cells and preventing premature differentiation into mature neurons (By similarity). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (PubMed:22960932). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (By similarity). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (By similarity). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (PubMed:22371606, PubMed:12657670). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (PubMed:25108103). Taurus_UMD|evm.model.AC_000163.1.388 Q32LB9 NOA1_BOVIN 99.712 0.946721 1.05476 NOA1 - Nitric oxide-associated protein 1 - Bos taurus (Bovine) - NOA1 gene Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP (By similarity). Taurus_UMD|evm.model.AC_000163.1.389 P30876 RPB2_HUMAN 99.915 0.998298 1.00085 POLR2B - DNA-directed RNA polymerase II subunit RPB2 - Homo sapiens (Human) - POLR2B gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity). Taurus_UMD|evm.model.AC_000163.1.390 Q16270 IBP7_HUMAN 95.745 0.992933 1.00355 IGFBP7 - Insulin-like growth factor-binding protein 7 precursor - Homo sapiens (Human) - IGFBP7 gene Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Taurus_UMD|evm.model.AC_000163.1.392 Q6ZQK0 CNDD3_MOUSE 50.820 0.394737 0.10093 Ncapd3 - Condensin-2 complex subunit D3 - Mus musculus (Mouse) - Ncapd3 gene Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size. Taurus_UMD|evm.model.AC_000163.1.395 Q0II59 PDXK_BOVIN 74.286 0.404762 0.269231 PDXK - Pyridoxal kinase - Bos taurus (Bovine) - PDXK gene Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (By similarity). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity). Taurus_UMD|evm.model.AC_000163.1.397 P54277 PMS1_HUMAN 87.500 0.670213 0.100858 PMS1 - PMS1 protein homolog 1 - Homo sapiens (Human) - PMS1 gene Probably involved in the repair of mismatches in DNA. Taurus_UMD|evm.model.AC_000163.1.399 Q3T014 PMGE_BOVIN 100.000 0.966102 0.227799 BPGM - Bisphosphoglycerate mutase - Bos taurus (Bovine) - BPGM gene Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. Taurus_UMD|evm.model.AC_000163.1.400 P62856 RS26_RAT 97.872 0.978947 0.826087 Rps26 - 40S ribosomal protein S26 - Rattus norvegicus (Rat) - Rps26 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, mRNA binding, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000163.1.401 Q3SZ89 TECRL_BOVIN 100.000 0.955145 1.04408 TECRL - Trans-2,3-enoyl-CoA reductase-like - Bos taurus (Bovine) - TECRL gene oxidoreductase activity, very long-chain fatty acid biosynthetic process Taurus_UMD|evm.model.AC_000163.1.403 Q86YF9 DZIP1_HUMAN 75.691 0.972527 0.209919 DZIP1 - Zinc finger protein DZIP1 - Homo sapiens (Human) - DZIP1 gene May participate in spermatogenesis via its interaction with DAZ1 (PubMed:15081113). Has a role in primary cilium formation (PubMed:19852954). Taurus_UMD|evm.model.AC_000163.1.405 P54756 EPHA5_HUMAN 97.699 0.985552 0.934426 EPHA5 - Ephrin type-A receptor 5 precursor - Homo sapiens (Human) - EPHA5 gene Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). Taurus_UMD|evm.model.AC_000163.1.406 P49453 CENPC_SHEEP 86.500 0.412262 2.35323 CENPC - Centromere protein C - Ovis aries (Sheep) - CENPC gene Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. Taurus_UMD|evm.model.AC_000163.1.407 Q9ULZ2 STAP1_HUMAN 87.273 0.948097 0.979661 STAP1 - Signal-transducing adaptor protein 1 - Homo sapiens (Human) - STAP1 gene In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC. Taurus_UMD|evm.model.AC_000163.1.408 A0AVT1 UBA6_HUMAN 92.110 0.993384 1.0057 UBA6 - Ubiquitin-like modifier-activating enzyme 6 - Homo sapiens (Human) - UBA6 gene Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. Taurus_UMD|evm.model.AC_000163.1.409 P32236 GNRHR_BOVIN 100.000 0.993921 1.00305 GNRHR - Gonadotropin-releasing hormone receptor - Bos taurus (Bovine) - GNRHR gene Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000163.1.410 Q1JRP2 TM11C_MOUSE 69.565 0.991892 0.858469 Tmprss11c - Transmembrane protease serine 11C precursor - Mus musculus (Mouse) - Tmprss11c gene Serine protease which has a preference for Arg or Lys in position P1 and uncharged residues in positions P2 and P3. Shows specificity towards FGF2 in vitro. Taurus_UMD|evm.model.AC_000163.1.411 O60235 TM11D_HUMAN 70.433 0.898048 1.10287 TMPRSS11D - Transmembrane protease serine 11D precursor - Homo sapiens (Human) - TMPRSS11D gene May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate. Taurus_UMD|evm.model.AC_000163.1.412 Q6ZMR5 TM11A_HUMAN 78.095 0.995215 0.992874 TMPRSS11A - Transmembrane protease serine 11A - Homo sapiens (Human) - TMPRSS11A gene Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest. Taurus_UMD|evm.model.AC_000163.1.413 Q8BZ10 TM11G_MOUSE 70.321 0.98939 0.904077 Tmprss11g - Transmembrane protease serine 11G precursor - Mus musculus (Mouse) - Tmprss11g gene plasma membrane Taurus_UMD|evm.model.AC_000163.1.414 Q6ZWK6 TM11F_HUMAN 82.245 0.994778 0.874429 TMPRSS11F - Transmembrane protease serine 11F - Homo sapiens (Human) - TMPRSS11F gene Probable serine protease. Taurus_UMD|evm.model.AC_000163.1.415 Q14C59 TM11B_MOUSE 77.404 0.995204 1.0024 Tmprss11b - Transmembrane protease serine 11B-like protein - Mus musculus (Mouse) - Tmprss11b gene Serine protease. Taurus_UMD|evm.model.AC_000163.1.416 A6H767 NP1L1_BOVIN 99.488 0.994898 1.00256 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Taurus_UMD|evm.model.AC_000163.1.417 Q86T26 TM11B_HUMAN 64.146 0.886889 0.935096 TMPRSS11B - Transmembrane protease serine 11B - Homo sapiens (Human) - TMPRSS11B gene Serine protease. Taurus_UMD|evm.model.AC_000163.1.418 Q9UL52 TM11E_HUMAN 81.280 0.995272 1 TMPRSS11E - Transmembrane protease serine 11E precursor - Homo sapiens (Human) - TMPRSS11E gene Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. Taurus_UMD|evm.model.AC_000163.1.419 Q5JUK9 PAGE3_HUMAN 43.011 0.511494 1.53982 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Taurus_UMD|evm.model.AC_000163.1.420 Q96MU7 YTDC1_HUMAN 96.201 0.997286 1.01376 YTHDC1 - YTH domain-containing protein 1 - Homo sapiens (Human) - YTHDC1 gene Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). Taurus_UMD|evm.model.AC_000163.1.421 Q9BXW6 OSBL1_HUMAN 95.503 0.803838 0.493684 OSBPL1A - Oxysterol-binding protein-related protein 1 - Homo sapiens (Human) - OSBPL1A gene Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). Taurus_UMD|evm.model.AC_000163.1.422 Q6K1J1 UDB31_CANLF 74.340 0.990602 1.00377 UGT2B31 - UDP-glucuronosyltransferase 2B31 precursor - Canis lupus familiaris (Dog) - UGT2B31 gene UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs. Taurus_UMD|evm.model.AC_000163.1.423 P06133 UD2B4_HUMAN 69.508 0.989754 0.924242 UGT2B4 - UDP-glucuronosyltransferase 2B4 precursor - Homo sapiens (Human) - UGT2B4 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). Taurus_UMD|evm.model.AC_000163.1.424 P06133 UD2B4_HUMAN 74.669 0.996226 1.00379 UGT2B4 - UDP-glucuronosyltransferase 2B4 precursor - Homo sapiens (Human) - UGT2B4 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). Taurus_UMD|evm.model.AC_000163.1.425 P06133 UD2B4_HUMAN 74.858 0.990619 1.00947 UGT2B4 - UDP-glucuronosyltransferase 2B4 precursor - Homo sapiens (Human) - UGT2B4 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). Taurus_UMD|evm.model.AC_000163.1.426 P06133 UD2B4_HUMAN 75.803 0.990619 1.00947 UGT2B4 - UDP-glucuronosyltransferase 2B4 precursor - Homo sapiens (Human) - UGT2B4 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). Taurus_UMD|evm.model.AC_000163.1.427 P06133 UD2B4_HUMAN 74.480 0.996226 1.00379 UGT2B4 - UDP-glucuronosyltransferase 2B4 precursor - Homo sapiens (Human) - UGT2B4 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). Taurus_UMD|evm.model.AC_000163.1.429 P06133 UD2B4_HUMAN 75.425 0.990619 1.00947 UGT2B4 - UDP-glucuronosyltransferase 2B4 precursor - Homo sapiens (Human) - UGT2B4 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). Taurus_UMD|evm.model.AC_000163.1.430 Q6K1J1 UDB31_CANLF 88.496 0.982456 0.215094 UGT2B31 - UDP-glucuronosyltransferase 2B31 precursor - Canis lupus familiaris (Dog) - UGT2B31 gene UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs. Taurus_UMD|evm.model.AC_000163.1.431 Q6K1J1 UDB31_CANLF 66.667 0.656489 0.24717 UGT2B31 - UDP-glucuronosyltransferase 2B31 precursor - Canis lupus familiaris (Dog) - UGT2B31 gene UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs. Taurus_UMD|evm.model.AC_000163.1.432 P06133 UD2B4_HUMAN 74.812 0.996248 1.00947 UGT2B4 - UDP-glucuronosyltransferase 2B4 precursor - Homo sapiens (Human) - UGT2B4 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867). Taurus_UMD|evm.model.AC_000163.1.433 P36514 UD2C1_RABIT 75.665 0.507277 1.91633 UGT2C1 - UDP-glucuronosyltransferase 2C1 - Oryctolagus cuniculus (Rabbit) - UGT2C1 gene UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Taurus_UMD|evm.model.AC_000163.1.434 P0DTE5 UD2A2_HUMAN 80.364 0.33869 1.50933 UGT2A2 - UDP-glucuronosyltransferase 2A2 - Homo sapiens (Human) - UGT2A2 gene UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:19858781, PubMed:18719240, PubMed:23756265, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:19858781, PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormone estradiol (PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth (PubMed:19858781). Taurus_UMD|evm.model.AC_000163.1.435 P36514 UD2C1_RABIT 74.148 0.939623 1.05578 UGT2C1 - UDP-glucuronosyltransferase 2C1 - Oryctolagus cuniculus (Rabbit) - UGT2C1 gene UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Taurus_UMD|evm.model.AC_000163.1.436 O94966 UBP19_HUMAN 70.000 0.576471 0.0644917 USP19 - Ubiquitin carboxyl-terminal hydrolase 19 - Homo sapiens (Human) - USP19 gene Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains. Taurus_UMD|evm.model.AC_000163.1.437 Q9R110 UD2A3_CAVPO 75.285 0.990566 1 UGT2A3 - UDP-glucuronosyltransferase 2A3 precursor - Cavia porcellus (Guinea pig) - UGT2A3 gene UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). Taurus_UMD|evm.model.AC_000163.1.438 Q3T0Y3 ST1B1_BOVIN 100.000 0.993266 1.00338 SULT1B1 - Sulfotransferase family cytosolic 1B member 1 - Bos taurus (Bovine) - SULT1B1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine (By similarity). Taurus_UMD|evm.model.AC_000163.1.439 G3V9R3 ST1D1_RAT 83.051 0.993243 1.00339 Sult1d1 - Sulfotransferase 1 family member D1 - Rattus norvegicus (Rat) - Sult1d1 gene Sulfotransferase with broad substrate specificity that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, such as dopamine, prostaglandins, leukotriene E4, drugs and xenobiotic compounds. Has sulfotransferase activity towards p-nitrophenol, 2-naphthylamine and minoxidil (in vitro). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites (By similarity). Taurus_UMD|evm.model.AC_000163.1.440 P19217 ST1E1_BOVIN 99.322 0.993243 1.00339 SULT1E1 - Sulfotransferase 1E1 - Bos taurus (Bovine) - SULT1E1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:1900200) (By similarity). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity). Taurus_UMD|evm.model.AC_000163.1.441 O15381 NVL_HUMAN 95.455 0.923372 0.304907 NVL - Nuclear valosin-containing protein-like - Homo sapiens (Human) - NVL gene Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111). Taurus_UMD|evm.model.AC_000163.1.442 P02662 CASA1_BOVIN 65.888 0.835294 0.794393 CSN1S1 - Alpha-S1-casein precursor - Bos taurus (Bovine) - CSN1S1 gene Important role in the capacity of milk to transport calcium phosphate. Taurus_UMD|evm.model.AC_000163.1.443 P02666 CASB_BOVIN 100.000 0.944915 1.05357 CSN2 - Beta-casein precursor - Bos taurus (Bovine) - CSN2 gene Important role in determination of the surface properties of the casein micelles. Taurus_UMD|evm.model.AC_000163.1.445 A1YQ93 ODAM_BOVIN 99.621 0.992453 0.956679 ODAM - Odontogenic ameloblast-associated protein precursor - Bos taurus (Bovine) - ODAM gene Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. Taurus_UMD|evm.model.AC_000163.1.446 P42155 CASK_BISBO 98.507 0.985075 0.492647 CSN3 - Kappa-casein - Bison bonasus (European bison) - CSN3 gene Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk. Taurus_UMD|evm.model.AC_000163.1.449 Q96Q06 PLIN4_HUMAN 22.593 0.102454 3.42373 PLIN4 - Perilipin-4 - Homo sapiens (Human) - PLIN4 gene May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity). Taurus_UMD|evm.model.AC_000163.1.450 Q2TBJ9 CABS1_BOVIN 100.000 0.979747 1.01804 CABS1 - Calcium-binding and spermatid-specific protein 1 - Bos taurus (Bovine) - CABS1 gene Calcium-binding protein (By similarity). Essential for maintaining the structural integrity of the sperm flagella (By similarity). Taurus_UMD|evm.model.AC_000163.1.451 Q28983 ZAN_PIG 42.143 0.423313 0.131664 ZAN - Zonadhesin precursor - Sus scrofa (Pig) - ZAN gene Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling. Taurus_UMD|evm.model.AC_000163.1.452 P55859 PNPH_BOVIN 95.139 0.989655 1.00346 PNP - Purine nucleoside phosphorylase - Bos taurus (Bovine) - PNP gene Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (By similarity). Taurus_UMD|evm.model.AC_000163.1.453 Q8TAX7 MUC7_HUMAN 45.098 0.573643 0.68435 MUC7 - Mucin-7 precursor - Homo sapiens (Human) - MUC7 gene May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili. Taurus_UMD|evm.model.AC_000163.1.454 Q6UX39 AMTN_HUMAN 70.142 0.859504 1.15789 AMTN - Amelotin precursor - Homo sapiens (Human) - AMTN gene Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. Taurus_UMD|evm.model.AC_000163.1.455 O43683 BUB1_HUMAN 80.075 0.988806 0.247005 BUB1 - Mitotic checkpoint serine/threonine-protein kinase BUB1 - Homo sapiens (Human) - BUB1 gene Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. Taurus_UMD|evm.model.AC_000163.1.456 Q9XSX7 AMBN_BOVIN 92.891 0.983645 1.09184 AMBN - Ameloblastin precursor - Bos taurus (Bovine) - AMBN gene Involved in the mineralization and structural organization of enamel. Taurus_UMD|evm.model.AC_000163.1.457 O97939 ENAM_PIG 77.720 0.950956 1.05342 ENAM - Enamelin precursor - Sus scrofa (Pig) - ENAM gene Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. Taurus_UMD|evm.model.AC_000163.1.458 P0DUB2 IGJ_EQUAS 81.013 0.987342 1 JCHAIN - Immunoglobulin J chain precursor - Equus asinus (Donkey) - JCHAIN gene Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component. Taurus_UMD|evm.model.AC_000163.1.459 Q9NQZ2 SAS10_HUMAN 86.279 0.995789 0.991649 UTP3 - Something about silencing protein 10 - Homo sapiens (Human) - UTP3 gene Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Taurus_UMD|evm.model.AC_000163.1.460 Q7L099 RUFY3_HUMAN 98.961 0.563877 1.45203 RUFY3 - Protein RUFY3 - Homo sapiens (Human) - RUFY3 gene Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner (PubMed:25766321). Taurus_UMD|evm.model.AC_000163.1.461 Q12849 GRSF1_HUMAN 95.014 0.991736 0.75625 GRSF1 - G-rich sequence factor 1 precursor - Homo sapiens (Human) - GRSF1 gene Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381). Taurus_UMD|evm.model.AC_000163.1.462 Q8BPB0 MOB1B_MOUSE 100.000 0.990783 1.00463 Mob1b - MOB kinase activator 1B - Mus musculus (Mouse) - Mob1b gene Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L (By similarity). Taurus_UMD|evm.model.AC_000163.1.463 Q3MHR2 DCK_BOVIN 100.000 0.980545 0.988462 DCK - Deoxycytidine kinase - Bos taurus (Bovine) - DCK gene Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine. Taurus_UMD|evm.model.AC_000163.1.464 Q9GL77 S4A4_BOVIN 99.722 0.959929 1.04078 SLC4A4 - Electrogenic sodium bicarbonate cotransporter 1 - Bos taurus (Bovine) - SLC4A4 gene Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Taurus_UMD|evm.model.AC_000163.1.465 P19378 HSP7C_CRIGR 90.667 0.259649 0.441176 HSPA8 - Heat shock cognate 71 kDa protein - Cricetulus griseus (Chinese hamster) - HSPA8 gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. Interacts with VGF-derived peptide TLQP-21. Taurus_UMD|evm.model.AC_000163.1.466 Q3MHN5 VTDB_BOVIN 86.957 0.781955 0.841772 GC - Vitamin D-binding protein precursor - Bos taurus (Bovine) - GC gene Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. Taurus_UMD|evm.model.AC_000163.1.467 Q3MHN5 VTDB_BOVIN 99.367 0.987421 0.335443 GC - Vitamin D-binding protein precursor - Bos taurus (Bovine) - GC gene Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. Taurus_UMD|evm.model.AC_000163.1.468 Q9Y5X5 NPFF2_HUMAN 84.539 0.993443 0.584291 NPFFR2 - Neuropeptide FF receptor 2 - Homo sapiens (Human) - NPFFR2 gene Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000163.1.469 O15072 ATS3_HUMAN 92.816 0.998344 1.00249 ADAMTS3 - A disintegrin and metalloproteinase with thrombospondin motifs 3 precursor - Homo sapiens (Human) - ADAMTS3 gene Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens. Taurus_UMD|evm.model.AC_000163.1.470 Q8N8Q8 COX18_HUMAN 81.899 0.982456 1.02703 COX18 - Cytochrome c oxidase assembly protein COX18, mitochondrial precursor - Homo sapiens (Human) - COX18 gene Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). Taurus_UMD|evm.model.AC_000163.1.471 O75179 ANR17_HUMAN 98.391 0.994 0.96043 ANKRD17 - Ankyrin repeat domain-containing protein 17 - Homo sapiens (Human) - ANKRD17 gene Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). Taurus_UMD|evm.model.AC_000163.1.474 P02769 ALBU_BOVIN 99.832 0.352976 2.76771 ALB - Albumin precursor - Bos taurus (Bovine) - ALB gene Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (PubMed:22677715). The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (Probable). The rank order of affinity is zinc > calcium > magnesium (Probable). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017). Taurus_UMD|evm.model.AC_000163.1.475 Q8MJU5 FETA_CANLF 39.020 0.994595 0.91133 AFP - Alpha-fetoprotein precursor - Canis lupus familiaris (Dog) - AFP gene Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Taurus_UMD|evm.model.AC_000163.1.476 Q6ZTQ3 RASF6_HUMAN 81.790 0.856764 1.02168 RASSF6 - Ras association domain-containing protein 6 - Homo sapiens (Human) - RASSF6 gene Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity). Taurus_UMD|evm.model.AC_000163.1.477 P79255 IL8_BOVIN 100.000 0.980392 1.0099 CXCL8 - Interleukin-8 precursor - Bos taurus (Bovine) - CXCL8 gene IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). Taurus_UMD|evm.model.AC_000163.1.478 Q9H0P0 5NT3A_HUMAN 91.018 0.917355 1.08036 NT5C3A - Cytosolic 5'-nucleotidase 3A - Homo sapiens (Human) - NT5C3A gene Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) (PubMed:24603684). CMP seems to be the preferred substrate (PubMed:15968458). Taurus_UMD|evm.model.AC_000163.1.479 P80221 CXCL6_BOVIN 100.000 0.982301 1.00893 CXCL6 - C-X-C motif chemokine 6 precursor - Bos taurus (Bovine) - CXCL6 gene Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7) (By similarity). Taurus_UMD|evm.model.AC_000163.1.480 P02777 PLF4_BOVIN 93.151 0.243243 3.36364 PF4 - Platelet factor 4 - Bos taurus (Bovine) - PF4 gene Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation. Taurus_UMD|evm.model.AC_000163.1.481 O46675 GROG_BOVIN 100.000 0.616541 1.35714 Growth-regulated protein homolog gamma precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000163.1.482 P08317 IL8_CHICK 56.410 0.408602 0.902913 CXCL8 - Interleukin-8 precursor - Gallus gallus (Chicken) - CXCL8 gene May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils. Taurus_UMD|evm.model.AC_000163.1.483 O46675 GROG_BOVIN 89.474 0.895238 1.07143 Growth-regulated protein homolog gamma precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000163.1.484 O46677 GROB_BOVIN 100.000 0.980952 1.00962 Growth-regulated protein homolog beta precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000163.1.485 Q9H903 MTD2L_HUMAN 78.386 0.993485 0.884726 MTHFD2L - Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 - Homo sapiens (Human) - MTHFD2L gene mitochondrial matrix, mitochondrion, methenyltetrahydrofolate cyclohydrolase activity, methylenetetrahydrofolate dehydrogenase (NAD+) activity, methylenetetrahydrofolate dehydrogenase (NADP+) activity, folic acid metabolic process, tetrahydrofolate interconversion Taurus_UMD|evm.model.AC_000163.1.486 Q6UW88 EPGN_HUMAN 90.000 0.721212 1.07143 EPGN - Epigen precursor - Homo sapiens (Human) - EPGN gene Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. Taurus_UMD|evm.model.AC_000163.1.487 O14944 EREG_HUMAN 87.117 0.987805 0.970414 EREG - Proepiregulin precursor - Homo sapiens (Human) - EREG gene Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357). Taurus_UMD|evm.model.AC_000163.1.488 P15514 AREG_HUMAN 77.470 0.991935 0.984127 AREG - Amphiregulin precursor - Homo sapiens (Human) - AREG gene Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts. Taurus_UMD|evm.model.AC_000163.1.489 Q9TTC5 BTC_BOVIN 99.438 0.988827 1.00562 BTC - Probetacellulin precursor - Bos taurus (Bovine) - BTC gene Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells (By similarity). Taurus_UMD|evm.model.AC_000163.1.490 Q6UWI2 PARM1_HUMAN 71.613 0.993355 0.970968 PARM1 - Prostate androgen-regulated mucin-like protein 1 precursor - Homo sapiens (Human) - PARM1 gene May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis. Taurus_UMD|evm.model.AC_000163.1.492 Q96PM5 ZN363_HUMAN 91.188 0.992366 1.00383 RCHY1 - RING finger and CHY zinc finger domain-containing protein 1 - Homo sapiens (Human) - RCHY1 gene Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity. Taurus_UMD|evm.model.AC_000163.1.493 Q8TBB0 THAP6_HUMAN 89.640 0.991031 1.0045 THAP6 - THAP domain-containing protein 6 - Homo sapiens (Human) - THAP6 gene microtubule cytoskeleton Taurus_UMD|evm.model.AC_000163.1.494 O02772 FABPH_PIG 77.953 0.976744 0.969925 FABP3 - Fatty acid-binding protein, heart - Sus scrofa (Pig) - FABP3 gene FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Taurus_UMD|evm.model.AC_000163.1.495 Q5R754 CDKL2_PONAB 89.263 0.829825 1.15619 CDKL2 - Cyclin-dependent kinase-like 2 - Pongo abelii (Sumatran orangutan) - CDKL2 gene Taurus_UMD|evm.model.AC_000163.1.496 Q5R9L3 G3BP2_PONAB 98.548 0.971717 1.02697 G3BP2 - Ras GTPase-activating protein-binding protein 2 - Pongo abelii (Sumatran orangutan) - G3BP2 gene Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. Taurus_UMD|evm.model.AC_000163.1.497 P41541 USO1_BOVIN 100.000 0.997921 1.00104 USO1 - General vesicular transport factor p115 - Bos taurus (Bovine) - USO1 gene General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. Taurus_UMD|evm.model.AC_000163.1.499 O14830 PPE2_HUMAN 83.537 0.991892 0.982736 PPEF2 - Serine/threonine-protein phosphatase with EF-hands 2 - Homo sapiens (Human) - PPEF2 gene May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission. Taurus_UMD|evm.model.AC_000163.1.500 Q58DT1 RL7_BOVIN 96.330 0.878049 0.495968 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Taurus_UMD|evm.model.AC_000163.1.501 Q5KTC7 NAAA_RAT 79.758 0.921788 0.98895 Naaa - N-acylethanolamine-hydrolyzing acid amidase precursor - Rattus norvegicus (Rat) - Naaa gene Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-stearoylethanolamine > N-oleoylethanolamine > N-linoleoylethanolamine > N-arachidonoylethanolamine. Taurus_UMD|evm.model.AC_000163.1.502 A5D7C2 SDA1_BOVIN 99.855 0.997097 1.00145 SDAD1 - Protein SDA1 homolog - Bos taurus (Bovine) - SDAD1 gene Required for 60S pre-ribosomal subunits export to the cytoplasm. Taurus_UMD|evm.model.AC_000163.1.503 A9QWP9 CXCL9_BOVIN 100.000 0.984127 1.008 CXCL9 - C-X-C motif chemokine 9 precursor - Bos taurus (Bovine) - CXCL9 gene Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3 (By similarity). Taurus_UMD|evm.model.AC_000163.1.504 Q13508 NAR3_HUMAN 70.455 0.884793 1.11568 ART3 - Ecto-ADP-ribosyltransferase 3 precursor - Homo sapiens (Human) - ART3 gene extracellular exosome, extracellular region, intrinsic component of plasma membrane, plasma membrane, NAD+ ADP-ribosyltransferase activity, peptidyl-arginine ADP-ribosylation, protein ADP-ribosylation Taurus_UMD|evm.model.AC_000163.1.505 Q7Z3B4 NUP54_HUMAN 87.574 0.995816 0.942801 NUP54 - Nucleoporin p54 - Homo sapiens (Human) - NUP54 gene Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. Taurus_UMD|evm.model.AC_000163.1.506 Q14108 SCRB2_HUMAN 70.800 0.958874 0.966527 SCARB2 - Lysosome membrane protein 2 - Homo sapiens (Human) - SCARB2 gene Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. Taurus_UMD|evm.model.AC_000163.1.507 Q6ZV65 FA47E_HUMAN 63.158 0.995134 1.0458 FAM47E - Protein FAM47E - Homo sapiens (Human) - FAM47E gene Promotes histone methylation by localizing the arginine methyltransferase PRMT5 to chromatin. Taurus_UMD|evm.model.AC_000163.1.508 O95210 STBD1_HUMAN 65.928 0.99403 0.935754 STBD1 - Starch-binding domain-containing protein 1 - Homo sapiens (Human) - STBD1 gene Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. Taurus_UMD|evm.model.AC_000163.1.509 Q5M9N0 CD158_HUMAN 89.668 0.998179 0.986523 CCDC158 - Coiled-coil domain-containing protein 158 - Homo sapiens (Human) - CCDC158 gene Taurus_UMD|evm.model.AC_000163.1.510 Q9QXN0 SHRM3_MOUSE 77.966 0.449612 0.0649547 Shroom3 - Protein Shroom3 - Mus musculus (Mouse) - Shroom3 gene Controls cell shape changes in the neuroepithelium during neural tube closure (PubMed:10589677, PubMed:14680628). Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (PubMed:14680628, PubMed:16249236, PubMed:16684770, PubMed:22493320). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). Taurus_UMD|evm.model.AC_000163.1.511 Q8TF72 SHRM3_HUMAN 72.713 0.98275 0.958417 SHROOM3 - Protein Shroom3 - Homo sapiens (Human) - SHROOM3 gene Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). Taurus_UMD|evm.model.AC_000163.1.512 Q6NRK3 SWAHB_XENLA 76.471 0.0424165 0.95695 sowahb - Ankyrin repeat domain-containing protein SOWAHB - Xenopus laevis (African clawed frog) - sowahb gene Taurus_UMD|evm.model.AC_000163.1.513 A2VE99 SEP11_BOVIN 100.000 0.979215 1.01882 SEPTIN11 - Septin-11 - Bos taurus (Bovine) - SEPTIN11 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). Taurus_UMD|evm.model.AC_000163.1.514 Q14094 CCNI_HUMAN 94.960 0.994709 1.00265 CCNI - Cyclin-I - Homo sapiens (Human) - CCNI gene cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus, cyclin-dependent protein serine/threonine kinase regulator activity, mitotic cell cycle phase transition, regulation of cyclin-dependent protein serine/threonine kinase activity, spermatogenesis Taurus_UMD|evm.model.AC_000163.1.515 Q16589 CCNG2_HUMAN 93.605 0.838631 1.18895 CCNG2 - Cyclin-G2 - Homo sapiens (Human) - CCNG2 gene May play a role in growth regulation and in negative regulation of cell cycle progression. Taurus_UMD|evm.model.AC_000163.1.516 O43927 CXL13_HUMAN 51.402 0.963636 1.00917 CXCL13 - C-X-C motif chemokine 13 precursor - Homo sapiens (Human) - CXCL13 gene Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5. Taurus_UMD|evm.model.AC_000163.1.517 P62752 RL23A_RAT 100.000 0.974843 1.01923 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000163.1.518 Q96LI5 CNO6L_HUMAN 100.000 0.994987 0.718919 CNOT6L - CCR4-NOT transcription complex subunit 6-like - Homo sapiens (Human) - CNOT6L gene Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. Taurus_UMD|evm.model.AC_000163.1.519 Q96LI5 CNO6L_HUMAN 99.225 0.984615 0.234234 CNOT6L - CCR4-NOT transcription complex subunit 6-like - Homo sapiens (Human) - CNOT6L gene Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. Taurus_UMD|evm.model.AC_000163.1.520 A6QPQ5 RM01_BOVIN 100.000 0.993865 1.00308 MRPL1 - 39S ribosomal protein L1, mitochondrial precursor - Bos taurus (Bovine) - MRPL1 gene cytosolic large ribosomal subunit, mitochondrial inner membrane, RNA binding, maturation of LSU-rRNA Taurus_UMD|evm.model.AC_000163.1.521 Q86XX4 FRAS1_HUMAN 94.582 0.230247 0.918912 FRAS1 - Extracellular matrix organizing protein FRAS1 precursor - Homo sapiens (Human) - FRAS1 gene Involved in extracellular matrix organization (By similarity). Required for the regulation of epidermal-basement membrane adhesion responsible for proper organogenesis during embryonic development (By similarity). Involved in brain organization and function (By similarity). Taurus_UMD|evm.model.AC_000163.1.522 Q3SWX7 ANXA3_BOVIN 99.690 0.993827 1.0031 ANXA3 - Annexin A3 - Bos taurus (Bovine) - ANXA3 gene Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate (By similarity). Taurus_UMD|evm.model.AC_000163.1.523 Q9NSY1 BMP2K_HUMAN 80.343 0.998155 0.933678 BMP2K - BMP-2-inducible protein kinase - Homo sapiens (Human) - BMP2K gene May be involved in osteoblast differentiation. Taurus_UMD|evm.model.AC_000163.1.524 Q6TCH7 PAQR3_HUMAN 99.035 0.99359 1.00322 PAQR3 - Progestin and adipoQ receptor family member 3 - Homo sapiens (Human) - PAQR3 gene Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi. Taurus_UMD|evm.model.AC_000163.1.525 Q9BSU3 NAA11_HUMAN 90.868 0.947826 1.00437 NAA11 - N-alpha-acetyltransferase 11 - Homo sapiens (Human) - NAA11 gene Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex. Taurus_UMD|evm.model.AC_000163.1.526 Q63060 GLPK_RAT 85.221 0.871022 1.13931 Gk - Glycerol kinase - Rattus norvegicus (Rat) - Gk gene Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP. Taurus_UMD|evm.model.AC_000163.1.527 P63170 DYL1_RAT 100.000 0.977778 1.01124 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Taurus_UMD|evm.model.AC_000163.1.528 P58335 ANTR2_HUMAN 73.950 0.965602 0.832311 ANTXR2 - Anthrax toxin receptor 2 precursor - Homo sapiens (Human) - ANTXR2 gene Necessary for cellular interactions with laminin and the extracellular matrix. Taurus_UMD|evm.model.AC_000163.1.529 Q9NQV8 PRDM8_HUMAN 88.456 0.901055 1.10015 PRDM8 - PR domain zinc finger protein 8 - Homo sapiens (Human) - PRDM8 gene Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity). Taurus_UMD|evm.model.AC_000163.1.531 A0MTF4 FGF5_BOVIN 100.000 0.99262 1.0037 FGF5 - Fibroblast growth factor 5 precursor - Bos taurus (Bovine) - FGF5 gene Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity). Taurus_UMD|evm.model.AC_000163.1.532 Q2YDG2 CF299_BOVIN 100.000 0.972973 0.480519 CFAP299 - Cilia- and flagella-associated protein 299 - Bos taurus (Bovine) - CFAP299 gene May be involved in spermatogenesis. Taurus_UMD|evm.model.AC_000163.1.533 Q2YDG2 CF299_BOVIN 100.000 0.98374 0.532468 CFAP299 - Cilia- and flagella-associated protein 299 - Bos taurus (Bovine) - CFAP299 gene May be involved in spermatogenesis. Taurus_UMD|evm.model.AC_000163.1.534 P22444 BMP3_BOVIN 100.000 0.995798 1.00211 BMP3 - Bone morphogenetic protein 3 precursor - Bos taurus (Bovine) - BMP3 gene Induces cartilage and bone formation. Taurus_UMD|evm.model.AC_000163.1.535 Q13237 KGP2_HUMAN 98.358 0.993464 0.80315 PRKG2 - cGMP-dependent protein kinase 2 - Homo sapiens (Human) - PRKG2 gene Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). Taurus_UMD|evm.model.AC_000163.1.536 Q13237 KGP2_HUMAN 92.810 0.64135 0.311024 PRKG2 - cGMP-dependent protein kinase 2 - Homo sapiens (Human) - PRKG2 gene Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). Taurus_UMD|evm.model.AC_000163.1.537 A4IFE4 RGF1B_BOVIN 100.000 0.94012 1.06144 RASGEF1B - Ras-GEF domain-containing family member 1B - Bos taurus (Bovine) - RASGEF1B gene Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro). Taurus_UMD|evm.model.AC_000163.1.539 Q86AQ7 VAM7B_DICDI 27.907 0.932203 0.680769 vamp7B - Vesicle-associated membrane protein 7B - Dictyostelium discoideum (Slime mold) - vamp7B gene Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion (By similarity). Taurus_UMD|evm.model.AC_000163.1.540 Q14103 HNRPD_HUMAN 98.873 0.994382 1.00282 HNRNPD - Heterogeneous nuclear ribonucleoprotein D0 - Homo sapiens (Human) - HNRNPD gene Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. Taurus_UMD|evm.model.AC_000163.1.541 Q9Z130 HNRDL_MOUSE 99.668 0.712589 1.39867 Hnrnpdl - Heterogeneous nuclear ribonucleoprotein D-like - Mus musculus (Mouse) - Hnrnpdl gene Acts as a transcriptional regulator. Promotes transcription repression (By similarity). Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences (By similarity). Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs (By similarity). Binds both to nuclear and cytoplasmic poly(A) mRNAs (By similarity). Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers (By similarity). Binds to the 5'-ACUAGC-3' RNA consensus sequence (By similarity). Taurus_UMD|evm.model.AC_000163.1.542 Q0VD27 ENOPH_BOVIN 100.000 0.992366 1.00383 ENOPH1 - Enolase-phosphatase E1 - Bos taurus (Bovine) - ENOPH1 gene Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Taurus_UMD|evm.model.AC_000163.1.543 A5D7C9 T150C_BOVIN 100.000 0.992 1.00402 TMEM150C - Transmembrane protein 150C - Bos taurus (Bovine) - TMEM150C gene Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception. Taurus_UMD|evm.model.AC_000163.1.544 Q2KIA4 SCD5_BOVIN 100.000 0.994048 1.00299 SCD5 - Stearoyl-CoA desaturase 5 - Bos taurus (Bovine) - SCD5 gene Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways. Taurus_UMD|evm.model.AC_000163.1.545 Q5R4F4 SC31A_PONAB 93.860 0.191238 1.07324 SEC31A - Protein transport protein Sec31A - Pongo abelii (Sumatran orangutan) - SEC31A gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (By similarity). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). Taurus_UMD|evm.model.AC_000163.1.547 Q9H5L6 THAP9_HUMAN 85.762 0.996667 0.996678 THAP9 - DNA transposase THAP9 - Homo sapiens (Human) - THAP9 gene Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition. Taurus_UMD|evm.model.AC_000163.1.548 Q5RBN8 LIN54_PONAB 98.659 0.695594 1.41856 LIN54 - Protein lin-54 homolog - Pongo abelii (Sumatran orangutan) - LIN54 gene Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA. Taurus_UMD|evm.model.AC_000163.1.549 Q3SZA0 CSN4_BOVIN 100.000 0.995086 1.00246 COPS4 - COP9 signalosome complex subunit 4 - Bos taurus (Bovine) - COPS4 gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Taurus_UMD|evm.model.AC_000163.1.550 Q3ZCB2 PLAC8_BOVIN 100.000 0.982906 1.00862 PLAC8 - Placenta-specific gene 8 protein - Bos taurus (Bovine) - PLAC8 gene positive regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000163.1.551 Q3ZCB2 PLAC8_BOVIN 62.136 0.918182 0.948276 PLAC8 - Placenta-specific gene 8 protein - Bos taurus (Bovine) - PLAC8 gene positive regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000163.1.552 Q2KIQ4 COQ2_BOVIN 99.730 0.994624 1.0027 COQ2 - 4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor - Bos taurus (Bovine) - COQ2 gene Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. Taurus_UMD|evm.model.AC_000163.1.553 Q9MYY0 HPSE_BOVIN 95.585 0.922383 1.01651 HPSE - Heparanase precursor - Bos taurus (Bovine) - HPSE gene Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. Essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans. Acts as procoagulant by enhancing the generation of activated factor X/F10 in the presence of tissue factor/TF and activated factor VII/F7. Independent of its enzymatic activity, increases cell adhesion to the extracellular matrix (ECM). Enhances AKT1/PKB phosphorylation, possibly via interaction with a lipid raft-resident receptor. Plays a role in the regulation of osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis (By similarity). Taurus_UMD|evm.model.AC_000163.1.554 Q8TDG4 HELQ_HUMAN 76.757 0.99802 0.917348 HELQ - Helicase POLQ-like - Homo sapiens (Human) - HELQ gene Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase (PubMed:11751861). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904). Taurus_UMD|evm.model.AC_000163.1.555 P82917 RT18C_BOVIN 100.000 0.986111 1.00699 MRPS18C - 28S ribosomal protein S18c, mitochondrial precursor - Bos taurus (Bovine) - MRPS18C gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit rRNA binding, structural constituent of ribosome Taurus_UMD|evm.model.AC_000163.1.556 Q5E9P1 ABRX1_BOVIN 100.000 0.995134 1.00244 ABRAXAS1 - BRCA1-A complex subunit Abraxas 1 - Bos taurus (Bovine) - ABRAXAS1 gene Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Taurus_UMD|evm.model.AC_000163.1.557 Q53EU6 GPAT3_HUMAN 91.917 0.984055 1.01152 GPAT3 - Glycerol-3-phosphate acyltransferase 3 - Homo sapiens (Human) - GPAT3 gene Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:19318427). Taurus_UMD|evm.model.AC_000163.1.558 Q5RFL9 NONO_PONAB 93.210 0.98773 0.346072 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Taurus_UMD|evm.model.AC_000163.1.559 P78426 NKX61_HUMAN 94.022 0.99455 1 NKX6-1 - Homeobox protein Nkx-6.1 - Homo sapiens (Human) - NKX6-1 gene Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity). Taurus_UMD|evm.model.AC_000163.1.560 Q92903 CDS1_HUMAN 97.285 0.581794 1.64425 CDS1 - Phosphatidate cytidylyltransferase 1 - Homo sapiens (Human) - CDS1 gene Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:9407135, PubMed:25375833). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (PubMed:25375833). Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). Positively regulates the differentiation and development of adipocytes (By similarity). Taurus_UMD|evm.model.AC_000163.1.561 Q8IZQ1 WDFY3_HUMAN 96.739 0.987819 1.00113 WDFY3 - WD repeat and FYVE domain-containing protein 3 - Homo sapiens (Human) - WDFY3 gene Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400). Taurus_UMD|evm.model.AC_000163.1.564 Q8N264 RHG24_HUMAN 94.259 0.852908 1.17246 ARHGAP24 - Rho GTPase-activating protein 24 - Homo sapiens (Human) - ARHGAP24 gene Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. Taurus_UMD|evm.model.AC_000163.1.565 P53779 MK10_HUMAN 97.608 0.985816 0.911638 MAPK10 - Mitogen-activated protein kinase 10 - Homo sapiens (Human) - MAPK10 gene Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). Taurus_UMD|evm.model.AC_000163.1.566 Q66X52 LTOR5_PIG 84.615 0.978261 1.01099 LAMTOR5 - Ragulator complex protein LAMTOR5 - Sus scrofa (Pig) - LAMTOR5 gene As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Taurus_UMD|evm.model.AC_000163.1.567 Q28CQ4 UBC9_XENTR 98.601 0.986111 0.911392 ube2i - SUMO-conjugating enzyme UBC9 - Xenopus tropicalis (Western clawed frog) - ube2i gene Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation. Taurus_UMD|evm.model.AC_000163.1.568 Q12923 PTN13_HUMAN 92.889 0.48306 0.736419 PTPN13 - Tyrosine-protein phosphatase non-receptor type 13 - Homo sapiens (Human) - PTPN13 gene Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). Taurus_UMD|evm.model.AC_000163.1.569 A6QP84 SOAT_BOVIN 100.000 0.296912 1.11671 SLC10A6 - Solute carrier family 10 member 6 - Bos taurus (Bovine) - SLC10A6 gene Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner. Taurus_UMD|evm.model.AC_000163.1.570 Q96KX1 CD036_HUMAN 75.789 0.979167 0.820513 C4orf36 - Uncharacterized protein C4orf36 - Homo sapiens (Human) - C4orf36 gene Taurus_UMD|evm.model.AC_000163.1.571 P51825 AFF1_HUMAN 80.146 0.998363 1.00992 AFF1 - AF4/FMR2 family member 1 - Homo sapiens (Human) - AFF1 gene super elongation complex, transcription elongation factor complex, regulation of gene expression Taurus_UMD|evm.model.AC_000163.1.572 Q9P2G9 KLHL8_HUMAN 95.968 0.996764 0.996774 KLHL8 - Kelch-like protein 8 - Homo sapiens (Human) - KLHL8 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN. Taurus_UMD|evm.model.AC_000163.1.573 P84246 H33_RABIT 97.794 0.985401 1.00735 H3-3A - Histone H3.3 - Oryctolagus cuniculus (Rabbit) - H3-3A gene Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000163.1.574 Q7Z5P4 DHB13_HUMAN 87.368 0.943522 1.00333 HSD17B13 - 17-beta-hydroxysteroid dehydrogenase 13 precursor - Homo sapiens (Human) - HSD17B13 gene cytosol, lipid droplet, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, steroid dehydrogenase activity, lipid droplet organization, positive regulation of lipid biosynthetic process Taurus_UMD|evm.model.AC_000163.1.575 Q8NBQ5 DHB11_HUMAN 75.088 0.881295 0.926667 HSD17B11 - Estradiol 17-beta-dehydrogenase 11 precursor - Homo sapiens (Human) - HSD17B11 gene Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. Taurus_UMD|evm.model.AC_000163.1.576 Q5EAE5 JOS1_BOVIN 96.522 0.982759 0.574257 JOSD1 - Josephin-1 - Bos taurus (Bovine) - JOSD1 gene Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity). Taurus_UMD|evm.model.AC_000163.1.577 Q8BVU5 NUDT9_MOUSE 86.550 0.974286 1 Nudt9 - ADP-ribose pyrophosphatase, mitochondrial precursor - Mus musculus (Mouse) - Nudt9 gene Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. Taurus_UMD|evm.model.AC_000163.1.578 Q14515 SPRL1_HUMAN 70.721 0.851316 1.14458 SPARCL1 - SPARC-like protein 1 precursor - Homo sapiens (Human) - SPARCL1 gene endoplasmic reticulum lumen, extracellular region, extracellular space, calcium ion binding, collagen binding, extracellular matrix binding, anatomical structure development, cellular protein metabolic process, post-translational protein modification Taurus_UMD|evm.model.AC_000163.1.579 Q9NZW4 DSPP_HUMAN 57.585 0.577061 0.428901 DSPP - Dentin sialophosphoprotein precursor - Homo sapiens (Human) - DSPP gene DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals. Taurus_UMD|evm.model.AC_000163.1.580 Q95120 DMP1_BOVIN 99.412 0.992203 1.00588 DMP1 - Dentin matrix acidic phosphoprotein 1 precursor - Bos taurus (Bovine) - DMP1 gene May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity). Taurus_UMD|evm.model.AC_000163.1.582 Q28949 MA2B2_PIG 58.621 0.927386 0.968844 MAN2B2 - Epididymis-specific alpha-mannosidase precursor - Sus scrofa (Pig) - MAN2B2 gene Can digest both p-nitro-phenyl-alpha-D-mannoside and high mannose oligosaccharide (Man(8)-GlcNAc(2)). May be involved in sperm maturation. Has a possible role in specific sperm-egg interaction since sperm surface mannosidase acts like a receptor for mannose-containing oligosaccharides located on the zona pellucida. Taurus_UMD|evm.model.AC_000163.1.583 Q28949 MA2B2_PIG 68.021 0.973469 0.984925 MAN2B2 - Epididymis-specific alpha-mannosidase precursor - Sus scrofa (Pig) - MAN2B2 gene Can digest both p-nitro-phenyl-alpha-D-mannoside and high mannose oligosaccharide (Man(8)-GlcNAc(2)). May be involved in sperm maturation. Has a possible role in specific sperm-egg interaction since sperm surface mannosidase acts like a receptor for mannose-containing oligosaccharides located on the zona pellucida. Taurus_UMD|evm.model.AC_000163.1.584 Q9Y2T4 2ABG_HUMAN 99.764 0.961364 0.98434 PPP2R2C - Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform - Homo sapiens (Human) - PPP2R2C gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Taurus_UMD|evm.model.AC_000163.1.585 O76024 WFS1_HUMAN 86.854 0.987751 1.00899 WFS1 - Wolframin - Homo sapiens (Human) - WFS1 gene Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (PubMed:16989814). Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism (PubMed:23035048). Taurus_UMD|evm.model.AC_000163.1.587 Q9P0W2 HM20B_HUMAN 59.406 0.264151 1.17035 HMG20B - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related - Homo sapiens (Human) - HMG20B gene Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters. Taurus_UMD|evm.model.AC_000163.1.589 A6QR54 JKIP1_BOVIN 99.669 0.726835 1.32748 JAKMIP1 - Janus kinase and microtubule-interacting protein 1 - Bos taurus (Bovine) - JAKMIP1 gene Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements (By similarity). Taurus_UMD|evm.model.AC_000163.1.590 Q6ZRC1 CD050_HUMAN 37.591 0.116477 5.10145 C4orf50 - Uncharacterized protein C4orf50 - Homo sapiens (Human) - C4orf50 gene Taurus_UMD|evm.model.AC_000163.1.592 Q14194 DPYL1_HUMAN 97.552 0.99651 1.00175 CRMP1 - Dihydropyrimidinase-related protein 1 - Homo sapiens (Human) - CRMP1 gene Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). Taurus_UMD|evm.model.AC_000163.1.593 P57679 EVC_HUMAN 77.644 0.997917 0.967742 EVC - Ellis-van Creveld syndrome protein - Homo sapiens (Human) - EVC gene Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development. Taurus_UMD|evm.model.AC_000163.1.594 Q8MI28 LBN_BOVIN 96.182 0.998183 0.91067 EVC2 - Limbin - Bos taurus (Bovine) - EVC2 gene Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis. Taurus_UMD|evm.model.AC_000163.1.595 Q9JJX8 ST32B_MOUSE 95.664 0.994595 0.89372 Stk32b - Serine/threonine-protein kinase 32B - Mus musculus (Mouse) - Stk32b gene protein serine/threonine kinase activity, intracellular signal transduction, peptidyl-serine phosphorylation Taurus_UMD|evm.model.AC_000163.1.596 Q9NRR1 CYTL1_HUMAN 85.217 0.826087 1.01471 CYTL1 - Cytokine-like protein 1 precursor - Homo sapiens (Human) - CYTL1 gene extracellular space, signaling receptor binding, signal transduction Taurus_UMD|evm.model.AC_000163.1.597 O02786 MSX1_BOVIN 97.030 0.993421 1.0033 MSX1 - Homeobox protein MSX-1 - Bos taurus (Bovine) - MSX1 gene Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). Taurus_UMD|evm.model.AC_000163.1.599 Q9P2W9 STX18_HUMAN 93.433 0.994048 1.00299 STX18 - Syntaxin-18 - Homo sapiens (Human) - STX18 gene Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Taurus_UMD|evm.model.AC_000163.1.600 O15254 ACOX3_HUMAN 78.199 0.858696 1.05143 ACOX3 - Peroxisomal acyl-coenzyme A oxidase 3 - Homo sapiens (Human) - ACOX3 gene Oxidizes the CoA-esters of 2-methyl-branched fatty acids. Taurus_UMD|evm.model.AC_000163.1.601 Q8IYL2 TRM44_HUMAN 71.503 0.993447 1.00793 TRMT44 - Probable tRNA (uracil-O(2)-)-methyltransferase - Homo sapiens (Human) - TRMT44 gene Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase. Taurus_UMD|evm.model.AC_000163.1.602 Q96P69 GPR78_HUMAN 61.957 0.427885 0.573003 GPR78 - G-protein coupled receptor 78 - Homo sapiens (Human) - GPR78 gene Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. Taurus_UMD|evm.model.AC_000163.1.603 Q66K79 CBPZ_HUMAN 86.164 0.970543 0.989264 CPZ - Carboxypeptidase Z precursor - Homo sapiens (Human) - CPZ gene Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing. Taurus_UMD|evm.model.AC_000163.1.606 Q9NP08 HMX1_HUMAN 87.644 0.994253 1 HMX1 - Homeobox protein HMX1 - Homo sapiens (Human) - HMX1 gene DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear. Taurus_UMD|evm.model.AC_000163.1.607 P18825 ADA2C_HUMAN 86.486 0.50173 1.25108 ADRA2C - Alpha-2C adrenergic receptor - Homo sapiens (Human) - ADRA2C gene Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Taurus_UMD|evm.model.AC_000163.1.609 Q9Z130 HNRDL_MOUSE 82.022 0.318841 0.916944 Hnrnpdl - Heterogeneous nuclear ribonucleoprotein D-like - Mus musculus (Mouse) - Hnrnpdl gene Acts as a transcriptional regulator. Promotes transcription repression (By similarity). Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences (By similarity). Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs (By similarity). Binds both to nuclear and cytoplasmic poly(A) mRNAs (By similarity). Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers (By similarity). Binds to the 5'-ACUAGC-3' RNA consensus sequence (By similarity). Taurus_UMD|evm.model.AC_000163.1.610 Q99068 AMRP_RAT 73.196 0.783784 1.02778 Lrpap1 - Alpha-2-macroglobulin receptor-associated protein precursor - Rattus norvegicus (Rat) - Lrpap1 gene Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. Taurus_UMD|evm.model.AC_000163.1.611 Q18PE1 DOK7_HUMAN 81.064 0.761345 1.18056 DOK7 - Protein Dok-7 - Homo sapiens (Human) - DOK7 gene Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. Taurus_UMD|evm.model.AC_000163.1.612 Q6QNF4 HGFA_CANLF 85.714 0.538188 0.860856 HGFAC - Hepatocyte growth factor activator precursor - Canis lupus familiaris (Dog) - HGFAC gene Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. Taurus_UMD|evm.model.AC_000163.1.613 Q8CGE9 RGS12_MOUSE 77.794 0.812183 0.570601 Rgs12 - Regulator of G-protein signaling 12 - Mus musculus (Mouse) - Rgs12 gene Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Taurus_UMD|evm.model.AC_000163.1.615 Q62092 NSG1_MOUSE 98.780 0.230769 1.8973 Nsg1 - Neuronal vesicle trafficking-associated protein 1 - Mus musculus (Mouse) - Nsg1 gene Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway (PubMed:15187090, PubMed:12070131, PubMed:21084623, PubMed:16037816). Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (PubMed:16037816). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (By similarity). Taurus_UMD|evm.model.AC_000163.1.616 Q6ZSB9 ZBT49_HUMAN 80.260 0.997389 1.00131 ZBTB49 - Zinc finger and BTB domain-containing protein 49 - Homo sapiens (Human) - ZBTB49 gene Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. Taurus_UMD|evm.model.AC_000163.1.618 Q9NX58 LYAR_HUMAN 75.835 0.994778 1.01055 LYAR - Cell growth-regulating nucleolar protein - Homo sapiens (Human) - LYAR gene Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131). In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines (PubMed:31413131). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity). Taurus_UMD|evm.model.AC_000163.1.619 Q3T0S0 TM128_BOVIN 100.000 0.987952 1.00606 TMEM128 - Transmembrane protein 128 - Bos taurus (Bovine) - TMEM128 gene Taurus_UMD|evm.model.AC_000163.1.620 Q7RTM1 OTOP1_HUMAN 84.737 0.921824 1.00327 OTOP1 - Proton channel OTOP1 - Homo sapiens (Human) - OTOP1 gene Proton-selective channel that specifically transports protons into cells (PubMed:29371428). Proton channel activity is only weakly-sensitive to voltage (By similarity). Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes (PubMed:29371428). In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (By similarity). Probably acts by maintaining the pH appropriate for formation of otoconia (By similarity). Regulates purinergic control of intracellular calcium in vestibular supporting cells (By similarity). May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol (By similarity). Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction (By similarity). Taurus_UMD|evm.model.AC_000163.1.621 P21918 DRD5_HUMAN 84.134 0.995781 0.993711 DRD5 - D(1B) dopamine receptor - Homo sapiens (Human) - DRD5 gene Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Taurus_UMD|evm.model.AC_000163.1.622 Q9NRM0 GTR9_HUMAN 83.178 0.80303 0.244444 SLC2A9 - Solute carrier family 2, facilitated glucose transporter member 9 - Homo sapiens (Human) - SLC2A9 gene Urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed:18327257, PubMed:28083649). Does not transport glucose, fructose or galactose (PubMed:28083649). Taurus_UMD|evm.model.AC_000163.1.623 Q8BIL2 MSD1_MOUSE 89.231 0.973684 0.956835 Msantd1 - Myb/SANT-like DNA-binding domain-containing protein 1 - Mus musculus (Mouse) - Msantd1 gene nuclear body, positive regulation of transcription, DNA-templated Taurus_UMD|evm.model.AC_000163.1.624 P42858 HD_HUMAN 89.001 0.979566 0.996817 HTT - Huntingtin - Homo sapiens (Human) - HTT gene May play a role in microtubule-mediated transport or vesicle function. Taurus_UMD|evm.model.AC_000163.1.625 P32298 GRK4_HUMAN 77.178 0.818312 1.20934 GRK4 - G protein-coupled receptor kinase 4 - Homo sapiens (Human) - GRK4 gene Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. Taurus_UMD|evm.model.AC_000163.1.626 P78316 NOP14_HUMAN 77.136 0.986207 1.01517 NOP14 - Nucleolar protein 14 - Homo sapiens (Human) - NOP14 gene Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). Taurus_UMD|evm.model.AC_000163.1.628 Q0P5M9 MFS10_BOVIN 100.000 0.995624 1.00219 MFSD10 - Major facilitator superfamily domain-containing protein 10 - Bos taurus (Bovine) - MFSD10 gene Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump (By similarity). Taurus_UMD|evm.model.AC_000163.1.629 P35611 ADDA_HUMAN 87.404 0.997403 1.04478 ADD1 - Alpha-adducin - Homo sapiens (Human) - ADD1 gene Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Taurus_UMD|evm.model.AC_000163.1.630 P78314 3BP2_HUMAN 83.569 0.928808 1.07665 SH3BP2 - SH3 domain-binding protein 2 - Homo sapiens (Human) - SH3BP2 gene Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. Taurus_UMD|evm.model.AC_000163.1.631 Q8NFZ5 TNIP2_HUMAN 78.738 0.990698 1.00233 TNIP2 - TNFAIP3-interacting protein 2 - Homo sapiens (Human) - TNIP2 gene Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. Taurus_UMD|evm.model.AC_000163.1.632 P78312 F193A_HUMAN 79.435 0.83983 1.11542 FAM193A - Protein FAM193A - Homo sapiens (Human) - FAM193A gene Taurus_UMD|evm.model.AC_000163.1.633 Q9QZS2 RNF4_MOUSE 88.770 0.973262 0.963918 Rnf4 - E3 ubiquitin-protein ligase RNF4 - Mus musculus (Mouse) - Rnf4 gene E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. Taurus_UMD|evm.model.AC_000163.1.634 D6REC4 CFA99_HUMAN 70.704 0.547988 1.40741 CFAP99 - Cilia- and flagella-associated protein 99 - Homo sapiens (Human) - CFAP99 gene Taurus_UMD|evm.model.AC_000163.1.635 A0JMD2 LST2_DANRE 80.220 0.213948 0.873065 zfyve28 - Lateral signaling target protein 2 homolog - Danio rerio (Zebrafish) - zfyve28 gene Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity). Taurus_UMD|evm.model.AC_000163.1.636 Q14582 MAD4_HUMAN 90.909 0.990476 1.00478 MXD4 - Max dimerization protein 4 - Homo sapiens (Human) - MXD4 gene Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity). Taurus_UMD|evm.model.AC_000163.1.637 Q68CZ6 HAUS3_HUMAN 86.235 0.996678 0.998342 HAUS3 - HAUS augmin-like complex subunit 3 - Homo sapiens (Human) - HAUS3 gene Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Taurus_UMD|evm.model.AC_000163.1.639 Q7TQ07 DPOLN_MOUSE 76.812 0.245238 0.972222 Poln - DNA polymerase nu - Mus musculus (Mouse) - Poln gene DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template. Is the least accurate of the DNA polymerase A family (i.e. POLG, POLN and POLQ). Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity. Error-prone DNA polymerase that preferentially misincorporates dT regardless of template sequence. May play a role in TLS during interstrand cross-link (ICL) repair. May be involved in TLS when genomic replication is blocked by extremely large major groove DNA lesions. May function in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linking agents. Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with HELQ helicase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links. Taurus_UMD|evm.model.AC_000163.1.641 Q8N9F0 NAT8L_HUMAN 89.535 0.77027 0.735099 NAT8L - N-acetylaspartate synthetase - Homo sapiens (Human) - NAT8L gene Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. Taurus_UMD|evm.model.AC_000163.1.642 Q5H8A4 PIGG_HUMAN 76.327 0.994797 0.97762 PIGG - GPI ethanolamine phosphate transferase 2 - Homo sapiens (Human) - PIGG gene Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose. Taurus_UMD|evm.model.AC_000163.1.645 Q4A1L4 BECN1_BOVIN 86.000 0.485294 0.455357 BECN1 - Beclin-1 - Bos taurus (Bovine) - BECN1 gene Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity). Taurus_UMD|evm.model.AC_000163.1.646 Q4A1L4 BECN1_BOVIN 94.737 0.854545 0.245536 BECN1 - Beclin-1 - Bos taurus (Bovine) - BECN1 gene Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity). Taurus_UMD|evm.model.AC_000163.1.647 Q4A1L4 BECN1_BOVIN 95.385 0.633663 0.225446 BECN1 - Beclin-1 - Bos taurus (Bovine) - BECN1 gene Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity). Taurus_UMD|evm.model.AC_000163.1.648 P23439 PDE6B_BOVIN 88.863 0.997487 0.933177 PDE6B - Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor - Bos taurus (Bovine) - PDE6B gene Necessary for the formation of a functional phosphodiesterase holoenzyme (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity). May participate in processes of transmission and amplification of the visual signal (By similarity). Taurus_UMD|evm.model.AC_000163.1.649 Q00361 ATP5I_BOVIN 100.000 0.96 0.704225 ATP5ME - ATP synthase subunit e, mitochondrial - Bos taurus (Bovine) - ATP5ME gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Taurus_UMD|evm.model.AC_000163.1.650 P41691 MYL5_FELCA 63.529 0.329218 1.40462 MYL5 - Myosin light chain 5 - Felis catus (Cat) - MYL5 gene Taurus_UMD|evm.model.AC_000163.1.651 Q8CE47 S49A3_MOUSE 72.273 0.907527 0.901163 Slc49a3 - Solute carrier family 49 member A3 - Mus musculus (Mouse) - Slc49a3 gene Taurus_UMD|evm.model.AC_000163.1.652 Q07G17 PCGF3_XENTR 75.207 0.990476 0.867769 pcgf3 - Polycomb group RING finger protein 3 - Xenopus tropicalis (Western clawed frog) - pcgf3 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Taurus_UMD|evm.model.AC_000163.1.654 O14976 GAK_HUMAN 79.284 0.998424 0.967963 GAK - Cyclin-G-associated kinase - Homo sapiens (Human) - GAK gene Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. Taurus_UMD|evm.model.AC_000163.1.655 Q32PG7 TM175_BOVIN 91.667 0.995699 0.970772 TMEM175 - Endosomal/lysosomal potassium channel TMEM175 - Bos taurus (Bovine) - TMEM175 gene Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel. Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors. The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation. The lysoK(GF) complex is required to protect neurons against stress-induced damage. Taurus_UMD|evm.model.AC_000163.1.656 P52824 DGKQ_HUMAN 81.070 0.986185 0.998938 DGKQ - Diacylglycerol kinase theta - Homo sapiens (Human) - DGKQ gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9099683, PubMed:11309392, PubMed:22627129). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). Taurus_UMD|evm.model.AC_000163.1.657 P35475 IDUA_HUMAN 82.708 0.950311 0.986217 IDUA - Alpha-L-iduronidase precursor - Homo sapiens (Human) - IDUA gene extracellular exosome, lysosomal lumen, hydrolase activity, hydrolyzing O-glycosyl compounds, L-iduronidase activity, chondroitin sulfate catabolic process, dermatan sulfate catabolic process, disaccharide metabolic process, glycosaminoglycan catabolic process, heparin catabolic process Taurus_UMD|evm.model.AC_000163.1.659 Q8N441 FGRL1_HUMAN 90.356 0.85045 1.10119 FGFRL1 - Fibroblast growth factor receptor-like 1 precursor - Homo sapiens (Human) - FGFRL1 gene Has a negative effect on cell proliferation. Taurus_UMD|evm.model.AC_000163.1.661 Q495C1 RN212_HUMAN 73.604 0.657718 1.00337 RNF212 - Probable E3 SUMO-protein ligase RNF212 - Homo sapiens (Human) - RNF212 gene SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity). Taurus_UMD|evm.model.AC_000163.1.662 P27869 TMD11_CANLF 87.333 0.281132 2.46512 TMED11 - Transmembrane emp24 domain-containing protein 11 precursor - Canis lupus familiaris (Dog) - TMED11 gene Part of a complex whose function is to bind Ca(2+) to the ER membrane and thereby regulate the retention of ER resident proteins. Taurus_UMD|evm.model.AC_000163.1.663 O88712 CTBP1_MOUSE 97.756 0.499374 1.81179 Ctbp1 - C-terminal-binding protein 1 - Mus musculus (Mouse) - Ctbp1 gene Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Taurus_UMD|evm.model.AC_000163.1.667 Q3MHJ2 MAEA_BOVIN 100.000 0.985577 0.958525 MAEA - E3 ubiquitin-protein transferase MAEA - Bos taurus (Bovine) - MAEA gene Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (By similarity). Taurus_UMD|evm.model.AC_000163.1.668 F1MX48 UVSSA_BOVIN 98.686 0.975434 1.01022 UVSSA - UV-stimulated scaffold protein A - Bos taurus (Bovine) - UVSSA gene Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage (By similarity). Taurus_UMD|evm.model.AC_000163.1.677 P97440 SLBP_MOUSE 86.182 0.992754 1.00364 Slbp - Histone RNA hairpin-binding protein - Mus musculus (Mouse) - Slbp gene RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (By similarity). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs. Taurus_UMD|evm.model.AC_000163.1.678 Q08DK0 TM129_BOVIN 99.724 0.99449 1.00276 TMEM129 - E3 ubiquitin-protein ligase TM129 - Bos taurus (Bovine) - TMEM129 gene E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation. Taurus_UMD|evm.model.AC_000163.1.679 Q9JJ11 TACC3_MOUSE 61.538 0.127004 1.28526 Tacc3 - Transforming acidic coiled-coil-containing protein 3 - Mus musculus (Mouse) - Tacc3 gene Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (PubMed:17920017). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (By similarity). May be involved in the control of cell growth and differentiation. May have a role in embryonic development. Taurus_UMD|evm.model.AC_000163.1.680 P22607 FGFR3_HUMAN 88.089 0.997406 0.956576 FGFR3 - Fibroblast growth factor receptor 3 precursor - Homo sapiens (Human) - FGFR3 gene Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. Taurus_UMD|evm.model.AC_000163.1.681 Q0VCA3 LETM1_BOVIN 99.727 0.928844 1.07514 LETM1 - Mitochondrial proton/calcium exchanger protein precursor - Bos taurus (Bovine) - LETM1 gene Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity). Taurus_UMD|evm.model.AC_000163.1.683 O96028 NSD2_HUMAN 86.846 0.97877 1.00073 NSD2 - Histone-lysine N-methyltransferase NSD2 - Homo sapiens (Human) - NSD2 gene Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:27571355, PubMed:22099308, PubMed:19808676, PubMed:29728617). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). Taurus_UMD|evm.model.AC_000163.1.684 Q9H3P2 NELFA_HUMAN 96.667 0.123173 0.907197 NELFA - Negative elongation factor A - Homo sapiens (Human) - NELFA gene Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Taurus_UMD|evm.model.AC_000163.1.686 A0JNN8 CD048_BOVIN 100.000 0.979592 1.01031 Neuropeptide-like protein C4orf48 homolog precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000163.1.687 Q3T9X0 GTR9_MOUSE 81.325 0.637066 0.481413 Slc2a9 - Solute carrier family 2, facilitated glucose transporter member 9 - Mus musculus (Mouse) - Slc2a9 gene Urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed:19587147, PubMed:25100214). Does not transport glucose, fructose or galactose (By similarity). Taurus_UMD|evm.model.AC_000163.1.688 Q5RB09 GTR9_PONAB 77.239 0.748571 0.618375 SLC2A9 - Solute carrier family 2, facilitated glucose transporter member 9 - Pongo abelii (Sumatran orangutan) - SLC2A9 gene Urate transporter, which may play a role in the urate reabsorption by proximal tubules (By similarity). Does not transport glucose, fructose or galactose (By similarity). Taurus_UMD|evm.model.AC_000163.1.689 Q2KJH4 WDR1_BOVIN 97.851 0.911011 1.09406 WDR1 - WD repeat-containing protein 1 - Bos taurus (Bovine) - WDR1 gene Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity). Taurus_UMD|evm.model.AC_000163.1.690 Q9C0D4 Z518B_HUMAN 74.722 0.998146 1.00466 ZNF518B - Zinc finger protein 518B - Homo sapiens (Human) - ZNF518B gene Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes. Taurus_UMD|evm.model.AC_000163.1.691 Q7Z7G1 CLNK_HUMAN 70.726 0.962963 1.00935 CLNK - Cytokine-dependent hematopoietic cell linker - Homo sapiens (Human) - CLNK gene An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation (By similarity). Together with FGR, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). Acts as a positive regulator of both T-cell receptor and natural killer T (NKT) cell receptor signaling in CD4-positive NKT cells (By similarity). Together with MAP4K1, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). May be involved in tumor necrosis factor induced cell death by promoting reactive oxidative species generation, and MLKL oligomerization, ultimately leading to necrosis (By similarity). Involved in phosphorylation of LAT (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). Taurus_UMD|evm.model.AC_000163.1.693 O14792 HS3S1_HUMAN 95.361 0.376953 1.66775 HS3ST1 - Heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor - Homo sapiens (Human) - HS3ST1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Taurus_UMD|evm.model.AC_000163.1.695 Q10126 YSM6_CAEEL 25.974 0.513208 0.949821 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000163.1.696 Q3SWY9 RAB28_BOVIN 100.000 0.990991 1.00452 RAB28 - Ras-related protein Rab-28 precursor - Bos taurus (Bovine) - RAB28 gene ciliary basal body, ciliary rootlet, GDP binding, GTP binding Taurus_UMD|evm.model.AC_000163.1.698 P78367 NKX32_HUMAN 89.489 0.993958 0.993994 NKX3-2 - Homeobox protein Nkx-3.2 - Homo sapiens (Human) - NKX3-2 gene Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity). Taurus_UMD|evm.model.AC_000163.1.699 Q96IK1 BOD1_HUMAN 75.000 0.0372109 16.1243 BOD1 - Biorientation of chromosomes in cell division protein 1 - Homo sapiens (Human) - BOD1 gene Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. Taurus_UMD|evm.model.AC_000163.1.702 O02751 CFDP2_BOVIN 77.041 0.517241 0.636824 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000163.1.703 Q7Z5Q1 CPEB2_HUMAN 97.582 0.577608 1.33447 CPEB2 - Cytoplasmic polyadenylation element-binding protein 2 - Homo sapiens (Human) - CPEB2 gene May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195). Taurus_UMD|evm.model.AC_000163.1.704 Q9BXJ2 C1QT7_HUMAN 97.578 0.986301 1.01038 C1QTNF7 - Complement C1q tumor necrosis factor-related protein 7 precursor - Homo sapiens (Human) - C1QTNF7 gene Taurus_UMD|evm.model.AC_000163.1.705 Q9P2K1 C2D2A_HUMAN 84.012 0.998781 1.01296 CC2D2A - Coiled-coil and C2 domain-containing protein 2A - Homo sapiens (Human) - CC2D2A gene Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). Taurus_UMD|evm.model.AC_000163.1.706 A2VE78 FBXL5_BOVIN 99.699 0.941761 1.01881 FBXL5 - F-box/LRR-repeat protein 5 - Bos taurus (Bovine) - FBXL5 gene Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity). Taurus_UMD|evm.model.AC_000163.1.707 P0CF97 F200B_HUMAN 84.370 0.996627 0.902588 FAM200B - Protein FAM200B - Homo sapiens (Human) - FAM200B gene Taurus_UMD|evm.model.AC_000163.1.708 Q63072 BST1_RAT 77.465 0.880878 1 Bst1 - ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor - Rattus norvegicus (Rat) - Bst1 gene Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth. Taurus_UMD|evm.model.AC_000163.1.709 Q64244 CD38_RAT 48.739 0.83871 0.920792 Cd38 - ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 - Rattus norvegicus (Rat) - Cd38 gene Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Taurus_UMD|evm.model.AC_000163.1.710 Q9MZ06 FGFP1_BOVIN 100.000 0.991489 1.00427 FGFBP1 - Fibroblast growth factor-binding protein 1 precursor - Bos taurus (Bovine) - FGFBP1 gene Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth (By similarity). Taurus_UMD|evm.model.AC_000163.1.711 P55210 CASP7_HUMAN 77.193 0.297753 0.587459 CASP7 - Caspase-7 precursor - Homo sapiens (Human) - CASP7 gene Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. Taurus_UMD|evm.model.AC_000163.1.712 O43490 PROM1_HUMAN 54.779 0.941589 0.989595 PROM1 - Prominin-1 precursor - Homo sapiens (Human) - PROM1 gene May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439). Taurus_UMD|evm.model.AC_000163.1.713 Q4VBD2 TAPT1_MOUSE 93.173 0.676796 1.28369 Tapt1 - Transmembrane anterior posterior transformation protein 1 - Mus musculus (Mouse) - Tapt1 gene Plays a role in primary cilia formation (By similarity). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity). Taurus_UMD|evm.model.AC_000163.1.714 O43679 LDB2_HUMAN 98.660 0.994652 1.00268 LDB2 - LIM domain-binding protein 2 - Homo sapiens (Human) - LDB2 gene Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. Taurus_UMD|evm.model.AC_000163.1.719 Q3T0Z7 DHPR_BOVIN 100.000 0.99177 1.00413 QDPR - Dihydropteridine reductase - Bos taurus (Bovine) - QDPR gene The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases. Taurus_UMD|evm.model.AC_000163.1.720 A0PK11 CLRN2_HUMAN 93.534 0.991416 1.00431 CLRN2 - Clarin-2 - Homo sapiens (Human) - CLRN2 gene Taurus_UMD|evm.model.AC_000163.1.721 Q28949 MA2B2_PIG 76.087 0.235602 0.19196 MAN2B2 - Epididymis-specific alpha-mannosidase precursor - Sus scrofa (Pig) - MAN2B2 gene Can digest both p-nitro-phenyl-alpha-D-mannoside and high mannose oligosaccharide (Man(8)-GlcNAc(2)). May be involved in sperm maturation. Has a possible role in specific sperm-egg interaction since sperm surface mannosidase acts like a receptor for mannose-containing oligosaccharides located on the zona pellucida. Taurus_UMD|evm.model.AC_000163.1.722 Q28949 MA2B2_PIG 88.889 0.0210084 1.67437 MAN2B2 - Epididymis-specific alpha-mannosidase precursor - Sus scrofa (Pig) - MAN2B2 gene Can digest both p-nitro-phenyl-alpha-D-mannoside and high mannose oligosaccharide (Man(8)-GlcNAc(2)). May be involved in sperm maturation. Has a possible role in specific sperm-egg interaction since sperm surface mannosidase acts like a receptor for mannose-containing oligosaccharides located on the zona pellucida. Taurus_UMD|evm.model.AC_000163.1.723 Q28949 MA2B2_PIG 77.143 0.167472 0.624121 MAN2B2 - Epididymis-specific alpha-mannosidase precursor - Sus scrofa (Pig) - MAN2B2 gene Can digest both p-nitro-phenyl-alpha-D-mannoside and high mannose oligosaccharide (Man(8)-GlcNAc(2)). May be involved in sperm maturation. Has a possible role in specific sperm-egg interaction since sperm surface mannosidase acts like a receptor for mannose-containing oligosaccharides located on the zona pellucida. Taurus_UMD|evm.model.AC_000163.1.724 Q28949 MA2B2_PIG 68.464 0.962338 0.773869 MAN2B2 - Epididymis-specific alpha-mannosidase precursor - Sus scrofa (Pig) - MAN2B2 gene Can digest both p-nitro-phenyl-alpha-D-mannoside and high mannose oligosaccharide (Man(8)-GlcNAc(2)). May be involved in sperm maturation. Has a possible role in specific sperm-egg interaction since sperm surface mannosidase acts like a receptor for mannose-containing oligosaccharides located on the zona pellucida. Taurus_UMD|evm.model.AC_000163.1.725 Q3ZC61 MOFA1_BOVIN 100.000 0.984375 1.00787 MRFAP1 - MORF4 family-associated protein 1 - Bos taurus (Bovine) - MRFAP1 gene Taurus_UMD|evm.model.AC_000163.1.726 Q9NUP1 BL1S4_HUMAN 81.095 0.930233 0.990783 BLOC1S4 - Biogenesis of lysosome-related organelles complex 1 subunit 4 - Homo sapiens (Human) - BLOC1S4 gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. Taurus_UMD|evm.model.AC_000163.1.727 Q92628 K0232_HUMAN 87.536 0.998577 1.00717 KIAA0232 - Uncharacterized protein KIAA0232 - Homo sapiens (Human) - KIAA0232 gene Taurus_UMD|evm.model.AC_000163.1.729 A6H7I8 TBC14_BOVIN 100.000 0.997114 1.00145 TBC1D14 - TBC1 domain family member 14 - Bos taurus (Bovine) - TBC1D14 gene Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. Taurus_UMD|evm.model.AC_000163.1.730 Q95LS7 CCD96_MACFA 82.386 0.89313 0.701786 CCDC96 - Coiled-coil domain-containing protein 96 - Macaca fascicularis (Crab-eating macaque) - CCDC96 gene Taurus_UMD|evm.model.AC_000163.1.731 Q5RBN9 TAD2B_PONAB 94.627 0.994048 0.8 TADA2B - Transcriptional adapter 2-beta - Pongo abelii (Sumatran orangutan) - TADA2B gene Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. Taurus_UMD|evm.model.AC_000163.1.732 Q3SZC1 GRPE1_BOVIN 100.000 0.990826 1.00461 GRPEL1 - GrpE protein homolog 1, mitochondrial precursor - Bos taurus (Bovine) - GRPEL1 gene Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity). Taurus_UMD|evm.model.AC_000163.1.733 Q96PQ0 SORC2_HUMAN 83.230 0.461988 0.295082 SORCS2 - VPS10 domain-containing receptor SorCS2 precursor - Homo sapiens (Human) - SORCS2 gene The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:22155786, PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (By similarity). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814). Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (PubMed:22155786). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes. Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (By similarity). Taurus_UMD|evm.model.AC_000163.1.736 Q6NUJ1 SAPL1_HUMAN 58.800 0.921933 1.03263 PSAPL1 - Proactivator polypeptide-like 1 precursor - Homo sapiens (Human) - PSAPL1 gene May activate the lysosomal degradation of sphingolipids. Taurus_UMD|evm.model.AC_000163.1.738 Q8N556 AFAP1_HUMAN 92.293 0.56674 1.25205 AFAP1 - Actin filament-associated protein 1 - Homo sapiens (Human) - AFAP1 gene Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. Taurus_UMD|evm.model.AC_000163.1.739 Q6H8Q1 ABLM2_HUMAN 82.700 0.996205 0.86252 ABLIM2 - Actin-binding LIM protein 2 - Homo sapiens (Human) - ABLIM2 gene May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. Taurus_UMD|evm.model.AC_000163.1.743 Q8TE82 S3TC1_HUMAN 71.969 0.941089 1.00374 SH3TC1 - SH3 domain and tetratricopeptide repeat-containing protein 1 - Homo sapiens (Human) - SH3TC1 gene Taurus_UMD|evm.model.AC_000163.1.744 P83110 HTRA3_HUMAN 75.352 0.560976 0.543046 HTRA3 - Serine protease HTRA3 precursor - Homo sapiens (Human) - HTRA3 gene Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724). Taurus_UMD|evm.model.AC_000163.1.745 D3ZA76 HTRA3_RAT 88.462 0.647059 0.259259 Htra3 - Serine protease HTRA3 precursor - Rattus norvegicus (Rat) - Htra3 gene Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity). Taurus_UMD|evm.model.AC_000163.1.746 Q9D236 HTRA3_MOUSE 86.250 0.940945 0.553377 Htra3 - Serine protease HTRA3 precursor - Mus musculus (Mouse) - Htra3 gene Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (PubMed:15206957). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity). Taurus_UMD|evm.model.AC_000164.1.2 O08678 MARK1_RAT 42.478 0.918033 0.153846 Mark1 - Serine/threonine-protein kinase MARK1 - Rattus norvegicus (Rat) - Mark1 gene Serine/threonine-protein kinase (By similarity). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (PubMed:14517247, PubMed:14741102, PubMed:9108484). Taurus_UMD|evm.model.AC_000164.1.3 A6NF01 P121B_HUMAN 49.474 0.232673 0.484412 POM121B - Putative nuclear envelope pore membrane protein POM 121B - Homo sapiens (Human) - POM121B gene Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). Taurus_UMD|evm.model.AC_000164.1.5 P35916 VGFR3_HUMAN 87.150 0.30942 1.01247 FLT4 - Vascular endothelial growth factor receptor 3 precursor - Homo sapiens (Human) - FLT4 gene Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. Taurus_UMD|evm.model.AC_000164.1.6 P08548 LIN1_NYCCO 30.928 0.909524 0.166667 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Taurus_UMD|evm.model.AC_000164.1.7 Q9ULM6 CNOT6_HUMAN 97.487 0.931323 1.07181 CNOT6 - CCR4-NOT transcription complex subunit 6 - Homo sapiens (Human) - CNOT6 gene Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence. Taurus_UMD|evm.model.AC_000164.1.8 Q08DQ2 GFPT2_BOVIN 100.000 0.997072 1.00147 GFPT2 - Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 - Bos taurus (Bovine) - GFPT2 gene Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (By similarity). Taurus_UMD|evm.model.AC_000164.1.9 P45984 MK09_HUMAN 99.764 0.995294 1.00236 MAPK9 - Mitogen-activated protein kinase 9 - Homo sapiens (Human) - MAPK9 gene Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity). Taurus_UMD|evm.model.AC_000164.1.10 Q86XS8 GOLI_HUMAN 97.568 0.436686 2.01671 RNF130 - E3 ubiquitin-protein ligase RNF130 precursor - Homo sapiens (Human) - RNF130 gene May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase. Taurus_UMD|evm.model.AC_000164.1.11 Q66K14 TBC9B_HUMAN 90.700 0.998408 1.0048 TBC1D9B - TBC1 domain family member 9B - Homo sapiens (Human) - TBC1D9B gene May act as a GTPase-activating protein for Rab family protein(s). Taurus_UMD|evm.model.AC_000164.1.12 Q3ZBG8 MRNIP_BOVIN 99.458 0.994595 1.00271 MRNIP - MRN complex-interacting protein - Bos taurus (Bovine) - MRNIP gene Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair. Taurus_UMD|evm.model.AC_000164.1.13 Q13501 SQSTM_HUMAN 92.045 0.995465 1.00227 SQSTM1 - Sequestosome-1 - Homo sapiens (Human) - SQSTM1 gene Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357). Taurus_UMD|evm.model.AC_000164.1.14 Q812F8 MGT4B_MOUSE 91.908 0.980989 0.959854 Mgat4b - Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B - Mus musculus (Mouse) - Mgat4b gene Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis (By similarity). Taurus_UMD|evm.model.AC_000164.1.15 Q2NKS0 LTC4S_BOVIN 100.000 0.986755 1.00667 LTC4S - Leukotriene C4 synthase - Bos taurus (Bovine) - LTC4S gene Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions. Taurus_UMD|evm.model.AC_000164.1.16 Q92585 MAML1_HUMAN 86.373 0.995798 0.468504 MAML1 - Mastermind-like protein 1 - Homo sapiens (Human) - MAML1 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Taurus_UMD|evm.model.AC_000164.1.17 Q92585 MAML1_HUMAN 88.017 0.745342 0.316929 MAML1 - Mastermind-like protein 1 - Homo sapiens (Human) - MAML1 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Taurus_UMD|evm.model.AC_000164.1.18 Q6T264 MAML1_MOUSE 81.579 0.75 0.141176 Maml1 - Mastermind-like protein 1 - Mus musculus (Mouse) - Maml1 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Taurus_UMD|evm.model.AC_000164.1.19 P24643 CALX_CANLF 95.447 0.964169 1.03541 CANX - Calnexin precursor - Canis lupus familiaris (Dog) - CANX gene Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse (By similarity). Taurus_UMD|evm.model.AC_000164.1.20 Q9CVN6 CBY3_MOUSE 69.347 0.804878 1.04681 Cby3 - Protein chibby homolog 3 - Mus musculus (Mouse) - Cby3 gene Taurus_UMD|evm.model.AC_000164.1.21 P31943 HNRH1_HUMAN 100.000 0.995556 1.00223 HNRNPH1 - Heterogeneous nuclear ribonucleoprotein H - Homo sapiens (Human) - HNRNPH1 gene This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). Taurus_UMD|evm.model.AC_000164.1.22 Q96T51 RUFY1_HUMAN 89.845 0.995665 0.977401 RUFY1 - RUN and FYVE domain-containing protein 1 - Homo sapiens (Human) - RUFY1 gene Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. Taurus_UMD|evm.model.AC_000164.1.28 P79331 ATS2_BOVIN 100.000 0.998342 1.00083 ADAMTS2 - A disintegrin and metalloproteinase with thrombospondin motifs 2 precursor - Bos taurus (Bovine) - ADAMTS2 gene Cleaves the propeptides of type I and II collagen prior to fibril assembly (PubMed:7622483). Does not act on type III collagen (PubMed:7622483). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (By similarity). Taurus_UMD|evm.model.AC_000164.1.29 Q86Y25 Z354C_HUMAN 83.238 0.973783 0.963899 ZNF354C - Zinc finger protein 354C - Homo sapiens (Human) - ZNF354C gene May function as a transcription repressor. Binds to 5'-CCACA-3' core sequence. Suppresses osteogenic effects of RUNX2. May be involved in osteoblastic differentiation (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). Taurus_UMD|evm.model.AC_000164.1.30 B4DU55 ZN879_HUMAN 95.157 0.983294 0.744227 ZNF879 - Zinc finger protein 879 - Homo sapiens (Human) - ZNF879 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.31 B4DU55 ZN879_HUMAN 75.000 0.97541 0.216696 ZNF879 - Zinc finger protein 879 - Homo sapiens (Human) - ZNF879 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.32 P24049 RL17_RAT 98.370 0.989189 1.00543 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000164.1.33 O15303 GRM6_HUMAN 96.357 0.973624 0.994299 GRM6 - Metabotropic glutamate receptor 6 precursor - Homo sapiens (Human) - GRM6 gene G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. Taurus_UMD|evm.model.AC_000164.1.34 Q8N9F8 ZN454_HUMAN 89.060 0.996154 0.996169 ZNF454 - Zinc finger protein 454 - Homo sapiens (Human) - ZNF454 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.36 Q6ZN57 ZFP2_HUMAN 91.164 0.995699 1.00868 ZFP2 - Zinc finger protein 2 homolog - Homo sapiens (Human) - ZFP2 gene Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance. Taurus_UMD|evm.model.AC_000164.1.37 Q5TA31 RN187_HUMAN 92.340 0.835714 1.19149 RNF187 - E3 ubiquitin-protein ligase RNF187 - Homo sapiens (Human) - RNF187 gene E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8. Taurus_UMD|evm.model.AC_000164.1.38 Q8CGP0 H2B3B_MOUSE 99.206 0.984252 1.00794 H2bu1 - Histone H2B type 3-B - Mus musculus (Mouse) - H2bu1 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000164.1.39 Q4FZT6 H2A3_RAT 100.000 0.984733 1.00769 Histone H2A type 3 - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000164.1.40 Q6LED0 H31_RAT 97.059 0.574468 1.72794 Histone H3.1 - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000164.1.41 Q2T9Z0 TRI17_BOVIN 94.316 0.995585 0.953684 TRIM17 - E3 ubiquitin-protein ligase TRIM17 - Bos taurus (Bovine) - TRIM17 gene May function as a ubiquitin E3 ligase. Taurus_UMD|evm.model.AC_000164.1.42 A0JN74 TRI11_BOVIN 100.000 0.780936 1.27778 TRIM11 - E3 ubiquitin-protein ligase TRIM11 - Bos taurus (Bovine) - TRIM11 gene E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Taurus_UMD|evm.model.AC_000164.1.43 Q6P7Q4 LGUL_RAT 90.217 0.989189 1.00543 Glo1 - Lactoylglutathione lyase - Rattus norvegicus (Rat) - Glo1 gene Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). Taurus_UMD|evm.model.AC_000164.1.44 Q5VST9 OBSCN_HUMAN 74.402 0.184619 1.13253 OBSCN - Obscurin - Homo sapiens (Human) - OBSCN gene Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). Taurus_UMD|evm.model.AC_000164.1.45 Q5T440 CAF17_HUMAN 75.419 0.994429 1.00843 IBA57 - Putative transferase CAF17, mitochondrial precursor - Homo sapiens (Human) - IBA57 gene Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Taurus_UMD|evm.model.AC_000164.1.46 Q29RK8 CXG2_BOVIN 99.765 0.995316 0.995338 GJC2 - Gap junction gamma-2 protein - Bos taurus (Bovine) - GJC2 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems (By similarity). Taurus_UMD|evm.model.AC_000164.1.47 P46195 KGUA_BOVIN 100.000 0.895455 1.11111 GUK1 - Guanylate kinase - Bos taurus (Bovine) - GUK1 gene Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:8243671, PubMed:29515371, PubMed:7911663). Involved in the cGMP metabolism in photoreceptors (PubMed:29515371, PubMed:8243671). Taurus_UMD|evm.model.AC_000164.1.48 P0C2B8 RM55_BOVIN 100.000 0.886525 1.11905 MRPL55 - 39S ribosomal protein L55, mitochondrial precursor - Bos taurus (Bovine) - MRPL55 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000164.1.49 Q58DU0 MMTA2_BOVIN 100.000 0.991525 1.00426 MMTAG2 - Multiple myeloma tumor-associated protein 2 homolog - Bos taurus (Bovine) - MMTAG2 gene Taurus_UMD|evm.model.AC_000164.1.50 P84079 ARF1_RAT 100.000 0.989011 1.00552 Arf1 - ADP-ribosylation factor 1 - Rattus norvegicus (Rat) - Arf1 gene GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD). Taurus_UMD|evm.model.AC_000164.1.51 P27467 WNT3A_MOUSE 96.951 0.886179 1.0483 Wnt3a - Protein Wnt-3a precursor - Mus musculus (Mouse) - Wnt3a gene Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites (PubMed:8299937). Required for normal morphogenesis of the developing neural tube (PubMed:8299937). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720). Taurus_UMD|evm.model.AC_000164.1.52 Q8R5M2 WNT9A_MOUSE 94.556 0.99422 0.947945 Wnt9a - Protein Wnt-9a precursor - Mus musculus (Mouse) - Wnt9a gene Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development (PubMed:16818445). Plays a redundant role in maintaining joint integrity (PubMed:16818445). Taurus_UMD|evm.model.AC_000164.1.53 A1L453 PRS38_HUMAN 61.639 0.89911 1.03374 PRSS38 - Serine protease 38 precursor - Homo sapiens (Human) - PRSS38 gene serine-type endopeptidase activity, proteolysis Taurus_UMD|evm.model.AC_000164.1.54 P63324 RS12_RAT 72.727 0.965116 0.651515 Rps12 - 40S ribosomal protein S12 - Rattus norvegicus (Rat) - Rps12 gene cytosolic large ribosomal subunit, cytosolic small ribosomal subunit, structural constituent of ribosome, response to organonitrogen compound Taurus_UMD|evm.model.AC_000164.1.55 A6QP11 SNP47_BOVIN 99.762 0.871102 1.14524 SNAP47 - Synaptosomal-associated protein 47 - Bos taurus (Bovine) - SNAP47 gene May play a role in intracellular membrane fusion. Taurus_UMD|evm.model.AC_000164.1.56 Q9H9V9 JMJD4_HUMAN 75.650 0.992941 0.917927 JMJD4 - 2-oxoglutarate and iron-dependent oxygenase JMJD4 - Homo sapiens (Human) - JMJD4 gene Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1. Taurus_UMD|evm.model.AC_000164.1.57 Q96LW1 Z354B_HUMAN 86.297 0.996732 1 ZNF354B - Zinc finger protein 354B - Homo sapiens (Human) - ZNF354B gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.59 Q9HD20 AT131_HUMAN 94.684 0.998333 0.996678 ATP13A1 - Endoplasmic reticulum transmembrane helix translocase - Homo sapiens (Human) - ATP13A1 gene Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005). Taurus_UMD|evm.model.AC_000164.1.60 Q9P107 GMIP_HUMAN 84.124 0.99793 0.995876 GMIP - GEM-interacting protein - Homo sapiens (Human) - GMIP gene Stimulates, in vitro and in vivo, the GTPase activity of RhoA. Taurus_UMD|evm.model.AC_000164.1.61 Q9HBW0 LPAR2_HUMAN 94.017 0.994318 1.00285 LPAR2 - Lysophosphatidic acid receptor 2 - Homo sapiens (Human) - LPAR2 gene Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. Taurus_UMD|evm.model.AC_000164.1.62 Q9BYU1 PBX4_HUMAN 78.151 0.921671 1.02406 PBX4 - Pre-B-cell leukemia transcription factor 4 - Homo sapiens (Human) - PBX4 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, animal organ morphogenesis, brain development, embryonic organ development, eye development, neuron development Taurus_UMD|evm.model.AC_000164.1.63 Q8IUL8 CILP2_HUMAN 87.937 0.987047 1.00173 CILP2 - Cartilage intermediate layer protein 2 precursor - Homo sapiens (Human) - CILP2 gene May play a role in cartilage scaffolding. Taurus_UMD|evm.model.AC_000164.1.64 F6W8I0 YJEN3_MOUSE 79.920 0.992 0.996016 Yjefn3 - YjeF N-terminal domain-containing protein 3 - Mus musculus (Mouse) - Yjefn3 gene May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence (By similarity). May play a role in spermiogenesis and oogenesis (By similarity). Taurus_UMD|evm.model.AC_000164.1.65 Q95KV7 NDUAD_BOVIN 100.000 0.986207 1.00694 NDUFA13 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 - Bos taurus (Bovine) - NDUFA13 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. Taurus_UMD|evm.model.AC_000164.1.66 Q9BXA6 TSSK6_HUMAN 98.535 0.992701 1.00366 TSSK6 - Testis-specific serine/threonine-protein kinase 6 - Homo sapiens (Human) - TSSK6 gene Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). Taurus_UMD|evm.model.AC_000164.1.67 Q86YP4 P66A_HUMAN 92.114 0.985938 1.01106 GATAD2A - Transcriptional repressor p66-alpha - Homo sapiens (Human) - GATAD2A gene Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B. Taurus_UMD|evm.model.AC_000164.1.68 Q9D2X5 SCC4_MOUSE 99.837 0.995114 0.991922 Mau2 - MAU2 chromatid cohesion factor homolog - Mus musculus (Mouse) - Mau2 gene Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodim. eric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin Plays a role in sister chromatid cohesion and normal progression through prometaphase. Taurus_UMD|evm.model.AC_000164.1.69 Q8IWZ8 SUGP1_HUMAN 89.767 0.996855 0.986047 SUGP1 - SURP and G-patch domain-containing protein 1 - Homo sapiens (Human) - SUGP1 gene Plays a role in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000164.1.70 Q9BZW4 TM6S2_HUMAN 81.698 0.994695 1 TM6SF2 - Transmembrane 6 superfamily member 2 - Homo sapiens (Human) - TM6SF2 gene Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content (PubMed:24531328, PubMed:24927523). May function as sterol isomerase (PubMed:25566323). Taurus_UMD|evm.model.AC_000164.1.71 Q86UW8 HPLN4_HUMAN 96.269 0.995037 1.00249 HAPLN4 - Hyaluronan and proteoglycan link protein 4 precursor - Homo sapiens (Human) - HAPLN4 gene Binds to hyaluronic acid and may be involved in formation of the extracellular matrix. Taurus_UMD|evm.model.AC_000164.1.72 O14594 NCAN_HUMAN 75.421 0.998538 1.03558 NCAN - Neurocan core protein precursor - Homo sapiens (Human) - NCAN gene May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid. Taurus_UMD|evm.model.AC_000164.1.73 Q58DU8 NR2CA_BOVIN 97.222 0.986207 1.03571 NR2C2AP - Nuclear receptor 2C2-associated protein - Bos taurus (Bovine) - NR2C2AP gene May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes. Taurus_UMD|evm.model.AC_000164.1.74 O14593 RFXK_HUMAN 93.077 0.992337 1.00385 RFXANK - DNA-binding protein RFXANK - Homo sapiens (Human) - RFXANK gene Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (PubMed:9806546, PubMed:10072068, PubMed:10725724). May also potentiate the activation of RAF1 (By similarity). Taurus_UMD|evm.model.AC_000164.1.75 Q96FH0 BORC8_HUMAN 98.319 0.983333 1.0084 BORCS8 - BLOC-1-related complex subunit 8 - Homo sapiens (Human) - BORCS8 gene As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Taurus_UMD|evm.model.AC_000164.1.76 Q02080 MEF2B_HUMAN 90.234 0.691057 1.01096 MEF2B - Myocyte-specific enhancer factor 2B - Homo sapiens (Human) - MEF2B gene Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription. Taurus_UMD|evm.model.AC_000164.1.77 Q9NX61 T161A_HUMAN 91.004 0.995825 1 TMEM161A - Transmembrane protein 161A precursor - Homo sapiens (Human) - TMEM161A gene May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. Taurus_UMD|evm.model.AC_000164.1.78 Q86VD7 S2542_HUMAN 92.767 0.99373 1.00314 SLC25A42 - Mitochondrial coenzyme A transporter SLC25A42 - Homo sapiens (Human) - SLC25A42 gene Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate. Taurus_UMD|evm.model.AC_000164.1.80 Q8BNU0 ARMC6_MOUSE 83.940 0.993603 1.00214 Armc6 - Armadillo repeat-containing protein 6 - Mus musculus (Mouse) - Armc6 gene cytosol, hematopoietic progenitor cell differentiation Taurus_UMD|evm.model.AC_000164.1.81 Q8IX01 SUGP2_HUMAN 84.182 0.956332 1.05823 SUGP2 - SURP and G-patch domain-containing protein 2 - Homo sapiens (Human) - SUGP2 gene May play a role in mRNA splicing. Taurus_UMD|evm.model.AC_000164.1.82 Q9NSC5 HOME3_HUMAN 91.413 0.994429 0.99446 HOMER3 - Homer protein homolog 3 - Homo sapiens (Human) - HOMER3 gene Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). Taurus_UMD|evm.model.AC_000164.1.83 Q9Y6V7 DDX49_HUMAN 94.595 0.991736 1.00207 DDX49 - Probable ATP-dependent RNA helicase DDX49 - Homo sapiens (Human) - DDX49 gene nucleoplasm, nucleus, RNA binding, positive regulation of cell growth, regulation of rRNA stability, rRNA processing Taurus_UMD|evm.model.AC_000164.1.84 Q28104 COPE_BOVIN 100.000 0.993528 1.00325 COPE - Coatomer subunit epsilon - Bos taurus (Bovine) - COPE gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Taurus_UMD|evm.model.AC_000164.1.85 P27544 CERS1_HUMAN 89.286 0.814181 1.16857 CERS1 - Ceramide synthase 1 - Homo sapiens (Human) - CERS1 gene Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA). Taurus_UMD|evm.model.AC_000164.1.86 P27539 GDF1_HUMAN 81.957 0.87027 0.994624 GDF1 - Embryonic growth/differentiation factor 1 precursor - Homo sapiens (Human) - GDF1 gene May mediate cell differentiation events during embryonic development. Taurus_UMD|evm.model.AC_000164.1.87 Q92900 RENT1_HUMAN 98.230 0.998209 0.989371 UPF1 - Regulator of nonsense transcripts 1 - Homo sapiens (Human) - UPF1 gene RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability. Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA hardoring long 3'UTR by inducing the NMD machinery (By similarity). Taurus_UMD|evm.model.AC_000164.1.88 P35445 COMP_BOVIN 92.725 0.997195 0.943122 COMP - Cartilage oligomeric matrix protein precursor - Bos taurus (Bovine) - COMP gene May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). Taurus_UMD|evm.model.AC_000164.1.89 Q6UUV9 CRTC1_HUMAN 89.238 0.997015 1.05678 CRTC1 - CREB-regulated transcription coactivator 1 - Homo sapiens (Human) - CRTC1 gene Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. Taurus_UMD|evm.model.AC_000164.1.90 Q53HC5 KLH26_HUMAN 95.777 0.962541 0.998374 KLHL26 - Kelch-like protein 26 - Homo sapiens (Human) - KLHL26 gene Taurus_UMD|evm.model.AC_000164.1.91 Q0VCT2 TM59L_BOVIN 100.000 0.994286 1.00287 TMEM59L - Transmembrane protein 59-like precursor - Bos taurus (Bovine) - TMEM59L gene Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding (By similarity). Taurus_UMD|evm.model.AC_000164.1.92 Q9JM58 CRLF1_MOUSE 97.814 0.914787 0.938824 Crlf1 - Cytokine receptor-like factor 1 precursor - Mus musculus (Mouse) - Crlf1 gene In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (By similarity). Plays a role in the initiation and/or maintenance of suckling in neonatal mice (PubMed:10359701). May also play a regulatory role in the immune system (By similarity). Taurus_UMD|evm.model.AC_000164.1.93 Q17Q97 REX1B_BOVIN 99.444 0.98895 1.00556 REX1BD - Required for excision 1-B domain-containing protein - Bos taurus (Bovine) - REX1BD gene Taurus_UMD|evm.model.AC_000164.1.94 P62986 RL40_RAT 100.000 0.984496 1.00781 Uba52 - Ubiquitin-60S ribosomal protein L40 precursor - Rattus norvegicus (Rat) - Uba52 gene Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). Taurus_UMD|evm.model.AC_000164.1.95 Q3SZV2 KXDL1_BOVIN 99.432 0.91623 1.08523 KXD1 - KxDL motif-containing protein 1 - Bos taurus (Bovine) - KXD1 gene As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May also be involved in the biogenesis of lysosome-related organelles such as melanosomes. Taurus_UMD|evm.model.AC_000164.1.96 Q14318 FKBP8_HUMAN 94.964 0.949074 1.04854 FKBP8 - Peptidyl-prolyl cis-trans isomerase FKBP8 - Homo sapiens (Human) - FKBP8 gene Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Taurus_UMD|evm.model.AC_000164.1.97 P55199 ELL_HUMAN 88.245 0.996759 0.993559 ELL - RNA polymerase II elongation factor ELL - Homo sapiens (Human) - ELL gene Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. Taurus_UMD|evm.model.AC_000164.1.98 Q2NL29 INO1_BOVIN 100.000 0.996416 1.0018 ISYNA1 - Inositol-3-phosphate synthase 1 - Bos taurus (Bovine) - ISYNA1 gene Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). Taurus_UMD|evm.model.AC_000164.1.99 Q9BWG4 SSBP4_HUMAN 89.119 0.99455 0.953247 SSBP4 - Single-stranded DNA-binding protein 4 - Homo sapiens (Human) - SSBP4 gene nucleus, positive regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000164.1.100 Q8MII8 LRC25_BOVIN 98.371 0.993485 1 LRRC25 - Leucine-rich repeat-containing protein 25 precursor - Bos taurus (Bovine) - LRRC25 gene Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy. Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA. Taurus_UMD|evm.model.AC_000164.1.101 Q99988 GDF15_HUMAN 65.273 0.993528 1.00325 GDF15 - Growth/differentiation factor 15 precursor - Homo sapiens (Human) - GDF15 gene Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity). Taurus_UMD|evm.model.AC_000164.1.102 Q9NXJ5 PGPI_HUMAN 98.565 0.990476 1.00478 PGPEP1 - Pyroglutamyl-peptidase 1 - Homo sapiens (Human) - PGPEP1 gene Removes 5-oxoproline from various penultimate amino acid residues except L-proline. Taurus_UMD|evm.model.AC_000164.1.103 P02301 H3C_MOUSE 98.936 0.645833 1.05882 H3-5 - Histone H3.3C - Mus musculus (Mouse) - H3-5 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000164.1.104 Q9Y4Z0 LSM4_HUMAN 100.000 0.901316 1.09353 LSM4 - U6 snRNA-associated Sm-like protein LSm4 - Homo sapiens (Human) - LSM4 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). Taurus_UMD|evm.model.AC_000164.1.105 Q8WNU4 IQCN_MACFA 52.367 0.943574 0.273585 IQCN - IQ domain-containing protein N - Macaca fascicularis (Crab-eating macaque) - IQCN gene Taurus_UMD|evm.model.AC_000164.1.106 A7YY54 JUND_BOVIN 99.712 0.994253 1.00288 JUND - Transcription factor jun-D - Bos taurus (Bovine) - JUND gene Transcription factor binding AP-1 sites. Taurus_UMD|evm.model.AC_000164.1.108 Q9H0B3 IQCN_HUMAN 52.157 0.642766 0.661864 IQCN - IQ domain-containing protein N - Homo sapiens (Human) - IQCN gene mitochondrion, nucleus Taurus_UMD|evm.model.AC_000164.1.109 Q9H0B3 IQCN_HUMAN 46.364 0.297372 0.612712 IQCN - IQ domain-containing protein N - Homo sapiens (Human) - IQCN gene mitochondrion, nucleus Taurus_UMD|evm.model.AC_000164.1.110 P14644 PDE4C_RAT 82.443 0.538066 1.81343 Pde4c - cAMP-specific 3',5'-cyclic phosphodiesterase 4C - Rattus norvegicus (Rat) - Pde4c gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Taurus_UMD|evm.model.AC_000164.1.111 P11023 RAB3A_BOVIN 100.000 0.793478 1.25455 RAB3A - Ras-related protein Rab-3A - Bos taurus (Bovine) - RAB3A gene Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (By similarity). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (By similarity). Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity). Taurus_UMD|evm.model.AC_000164.1.112 A5D787 M17L2_BOVIN 100.000 0.92735 1.07339 MPV17L2 - Mpv17-like protein 2 - Bos taurus (Bovine) - MPV17L2 gene Required for the assembly and stability of the mitochondrial ribosome (By similarity). Is a positive regulator of mitochondrial protein synthesis (By similarity). Taurus_UMD|evm.model.AC_000164.1.113 A6QPN6 GILT_BOVIN 99.590 0.991837 1.0041 IFI30 - Gamma-interferon-inducible lysosomal thiol reductase precursor - Bos taurus (Bovine) - IFI30 gene Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity). Taurus_UMD|evm.model.AC_000164.1.114 P23726 P85B_BOVIN 100.000 0.997241 1.00138 PIK3R2 - Phosphatidylinositol 3-kinase regulatory subunit beta - Bos taurus (Bovine) - PIK3R2 gene Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy. Promotes nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). Taurus_UMD|evm.model.AC_000164.1.116 O60307 MAST3_HUMAN 89.201 0.998513 1.0275 MAST3 - Microtubule-associated serine/threonine-protein kinase 3 - Homo sapiens (Human) - MAST3 gene protein serine/threonine kinase activity, cytoskeleton organization, intracellular signal transduction, peptidyl-serine phosphorylation Taurus_UMD|evm.model.AC_000164.1.117 P42701 I12R1_HUMAN 71.118 0.884457 1.09819 IL12RB1 - Interleukin-12 receptor subunit beta-1 precursor - Homo sapiens (Human) - IL12RB1 gene Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. Taurus_UMD|evm.model.AC_000164.1.118 Q8TBH0 ARRD2_HUMAN 80.348 0.98263 0.990172 ARRDC2 - Arrestin domain-containing protein 2 - Homo sapiens (Human) - ARRDC2 gene cytoplasm, cytoplasmic vesicle, plasma membrane, protein transport Taurus_UMD|evm.model.AC_000164.1.119 Q92952 KCNN1_HUMAN 92.449 0.800591 1.24678 KCNN1 - Small conductance calcium-activated potassium channel protein 1 - Homo sapiens (Human) - KCNN1 gene Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity). Taurus_UMD|evm.model.AC_000164.1.120 Q2TBV6 CC124_BOVIN 100.000 0.991071 1.00448 CCDC124 - Coiled-coil domain-containing protein 124 - Bos taurus (Bovine) - CCDC124 gene Required for proper progression of late cytokinetic stages. Taurus_UMD|evm.model.AC_000164.1.121 Q92911 SC5A5_HUMAN 88.455 0.973466 0.937792 SLC5A5 - Sodium/iodide cotransporter - Homo sapiens (Human) - SLC5A5 gene Mediates iodide uptake in the thyroid gland. Taurus_UMD|evm.model.AC_000164.1.122 Q02543 RL18A_HUMAN 100.000 0.988701 1.00568 RPL18A - 60S ribosomal protein L18a - Homo sapiens (Human) - RPL18A gene cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, polysomal ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, rRNA processing Taurus_UMD|evm.model.AC_000164.1.123 P52333 JAK3_HUMAN 90.147 0.996327 0.968861 JAK3 - Tyrosine-protein kinase JAK3 - Homo sapiens (Human) - JAK3 gene Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. Taurus_UMD|evm.model.AC_000164.1.124 O77801 INSL3_BOVIN 100.000 0.984962 1.00758 INSL3 - Insulin-like 3 precursor - Bos taurus (Bovine) - INSL3 gene Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). Taurus_UMD|evm.model.AC_000164.1.125 Q9Y2A9 B3GN3_HUMAN 72.849 0.994638 1.00269 B3GNT3 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 - Homo sapiens (Human) - B3GNT3 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191). Taurus_UMD|evm.model.AC_000164.1.126 O14526 FCHO1_HUMAN 89.062 0.997765 1.00675 FCHO1 - F-BAR domain only protein 1 - Homo sapiens (Human) - FCHO1 gene Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Taurus_UMD|evm.model.AC_000164.1.127 A6QQ70 MAP1S_BOVIN 99.719 0.998126 1.00094 MAP1S - Microtubule-associated protein 1S - Bos taurus (Bovine) - MAP1S gene Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). Taurus_UMD|evm.model.AC_000164.1.128 Q9UPW8 UN13A_HUMAN 95.794 0.998812 0.988256 UNC13A - Protein unc-13 homolog A - Homo sapiens (Human) - UNC13A gene Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (PubMed:23999003). Taurus_UMD|evm.model.AC_000164.1.129 A5PK45 GT251_BOVIN 100.000 0.996795 1.00161 COLGALT1 - Procollagen galactosyltransferase 1 precursor - Bos taurus (Bovine) - COLGALT1 gene Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the formation of collagen triple helix. Also involved in the biosynthesis of collagen type IV. Taurus_UMD|evm.model.AC_000164.1.130 Q86XR2 NIBA3_HUMAN 80.961 0.993174 0.840746 NIBAN3 - Protein Niban 3 - Homo sapiens (Human) - NIBAN3 gene Taurus_UMD|evm.model.AC_000164.1.131 Q2TBQ8 6PGL_BOVIN 99.612 0.992278 1.00388 PGLS - 6-phosphogluconolactonase - Bos taurus (Bovine) - PGLS gene Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. Taurus_UMD|evm.model.AC_000164.1.132 Q3ZKN0 S27A1_BOVIN 99.690 0.97432 1.02477 SLC27A1 - Long-chain fatty acid transport protein 1 - Bos taurus (Bovine) - SLC27A1 gene Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane. Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Probably involved in fatty acid transport across the blood barrier (By similarity). Taurus_UMD|evm.model.AC_000164.1.133 Q96CM4 NXNL1_HUMAN 86.911 0.86758 1.03302 NXNL1 - Nucleoredoxin-like protein 1 - Homo sapiens (Human) - NXNL1 gene Plays an important role in retinal cone photoreceptor survival (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and BSG, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (By similarity). Taurus_UMD|evm.model.AC_000164.1.134 A6NGB7 TM221_HUMAN 80.756 0.993151 1.00344 TMEM221 - Transmembrane protein 221 - Homo sapiens (Human) - TMEM221 gene Taurus_UMD|evm.model.AC_000164.1.135 Q3T0N1 MB12A_BOVIN 100.000 0.992701 1.00366 MVB12A - Multivesicular body subunit 12A - Bos taurus (Bovine) - MVB12A gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor (By similarity). Taurus_UMD|evm.model.AC_000164.1.136 Q10589 BST2_HUMAN 45.631 0.524862 1.00556 BST2 - Bone marrow stromal antigen 2 precursor - Homo sapiens (Human) - BST2 gene IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted (PubMed:22520941, PubMed:21529378, PubMed:20940320, PubMed:20419159, PubMed:20399176, PubMed:19879838, PubMed:19036818, PubMed:18342597, PubMed:18200009). Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, paramyxoviridae: nipah virus, and coronaviridae: SARS-CoV (PubMed:22520941, PubMed:21621240, PubMed:21529378, PubMed:20943977, PubMed:20686043, PubMed:20419159, PubMed:20399176, PubMed:19879838, PubMed:19179289, PubMed:18342597, PubMed:18200009, PubMed:26378163, PubMed:31199522). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration (PubMed:22065321). Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (PubMed:19564354, PubMed:26172439). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities (PubMed:23028328, PubMed:26172439). Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu (PubMed:23028328, PubMed:26172439). Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2 (PubMed:23028328). Taurus_UMD|evm.model.AC_000164.1.137 Q10589 BST2_HUMAN 48.113 0.597633 0.938889 BST2 - Bone marrow stromal antigen 2 precursor - Homo sapiens (Human) - BST2 gene IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted (PubMed:22520941, PubMed:21529378, PubMed:20940320, PubMed:20419159, PubMed:20399176, PubMed:19879838, PubMed:19036818, PubMed:18342597, PubMed:18200009). Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, paramyxoviridae: nipah virus, and coronaviridae: SARS-CoV (PubMed:22520941, PubMed:21621240, PubMed:21529378, PubMed:20943977, PubMed:20686043, PubMed:20419159, PubMed:20399176, PubMed:19879838, PubMed:19179289, PubMed:18342597, PubMed:18200009, PubMed:26378163, PubMed:31199522). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration (PubMed:22065321). Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (PubMed:19564354, PubMed:26172439). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities (PubMed:23028328, PubMed:26172439). Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu (PubMed:23028328, PubMed:26172439). Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2 (PubMed:23028328). Taurus_UMD|evm.model.AC_000164.1.138 A0A1B0GVG4 CC194_HUMAN 77.778 0.75502 1.0641 CCDC194 - Coiled-coil domain-containing protein 194 precursor - Homo sapiens (Human) - CCDC194 gene Taurus_UMD|evm.model.AC_000164.1.139 Q9BX97 PLVAP_HUMAN 75.566 0.995485 1.00226 PLVAP - Plasmalemma vesicle-associated protein - Homo sapiens (Human) - PLVAP gene Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development. Taurus_UMD|evm.model.AC_000164.1.140 Q969Y2 GTPB3_HUMAN 87.854 0.855652 1.1687 GTPBP3 - tRNA modification GTPase GTPBP3, mitochondrial precursor - Homo sapiens (Human) - GTPBP3 gene GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Taurus_UMD|evm.model.AC_000164.1.142 Q9HCE9 ANO8_HUMAN 84.826 0.998288 0.948052 ANO8 - Anoctamin-8 - Homo sapiens (Human) - ANO8 gene Does not exhibit calcium-activated chloride channel (CaCC) activity. Taurus_UMD|evm.model.AC_000164.1.143 Q5RD86 DDA1_PONAB 100.000 0.980583 1.0098 DDA1 - DET1- and DDB1-associated protein 1 - Pongo abelii (Sumatran orangutan) - DDA1 gene Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex. Taurus_UMD|evm.model.AC_000164.1.144 Q17QP1 ABHD8_BOVIN 100.000 0.995381 1.00231 ABHD8 - Protein ABHD8 - Bos taurus (Bovine) - ABHD8 gene mitochondrion, carboxylic ester hydrolase activity, lysophosphatidic acid acyltransferase activity, lipid homeostasis, phosphatidic acid biosynthetic process Taurus_UMD|evm.model.AC_000164.1.145 Q8NAG6 ANKL1_HUMAN 67.197 0.908133 1.07967 ANKLE1 - Ankyrin repeat and LEM domain-containing protein 1 - Homo sapiens (Human) - ANKLE1 gene Endonuclease that probably plays a role in the DNA damage response and DNA repair. Taurus_UMD|evm.model.AC_000164.1.146 Q08E57 BABA1_BOVIN 100.000 0.993994 1.00301 BABAM1 - BRISC and BRCA1-A complex member 1 - Bos taurus (Bovine) - BABAM1 gene Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Taurus_UMD|evm.model.AC_000164.1.147 Q8N6Y0 USBP1_HUMAN 75.960 0.997139 0.99431 USHBP1 - Usher syndrome type-1C protein-binding protein 1 - Homo sapiens (Human) - USHBP1 gene PDZ domain binding Taurus_UMD|evm.model.AC_000164.1.148 P10588 NR2F6_HUMAN 95.894 0.995157 1.02228 NR2F6 - Nuclear receptor subfamily 2 group F member 6 - Homo sapiens (Human) - NR2F6 gene Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). Taurus_UMD|evm.model.AC_000164.1.149 Q9H607 OCEL1_HUMAN 78.365 0.990338 0.784091 OCEL1 - Occludin/ELL domain-containing protein 1 - Homo sapiens (Human) - OCEL1 gene Taurus_UMD|evm.model.AC_000164.1.150 Q9NZ43 USE1_HUMAN 93.846 0.945255 1.05792 USE1 - Vesicle transport protein USE1 - Homo sapiens (Human) - USE1 gene SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Taurus_UMD|evm.model.AC_000164.1.151 Q13459 MYO9B_HUMAN 85.622 0.999074 1.00139 MYO9B - Unconventional myosin-IXb - Homo sapiens (Human) - MYO9B gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). Taurus_UMD|evm.model.AC_000164.1.152 Q9BT25 HAUS8_HUMAN 64.151 0.991643 0.87561 HAUS8 - HAUS augmin-like complex subunit 8 - Homo sapiens (Human) - HAUS8 gene Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Taurus_UMD|evm.model.AC_000164.1.154 Q8IZJ3 CPMD8_HUMAN 85.050 0.984941 0.951194 CPAMD8 - C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 precursor - Homo sapiens (Human) - CPAMD8 gene eye development Taurus_UMD|evm.model.AC_000164.1.155 Q96RI0 PAR4_HUMAN 77.403 0.994737 0.987013 F2RL3 - Proteinase-activated receptor 4 precursor - Homo sapiens (Human) - F2RL3 gene Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. Taurus_UMD|evm.model.AC_000164.1.156 O75182 SIN3B_HUMAN 92.301 0.983972 0.966437 SIN3B - Paired amphipathic helix protein Sin3b - Homo sapiens (Human) - SIN3B gene Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. Taurus_UMD|evm.model.AC_000164.1.157 Q149M9 NWD1_HUMAN 81.795 0.988506 1.00128 NWD1 - NACHT domain- and WD repeat-containing protein 1 - Homo sapiens (Human) - NWD1 gene May play a role in the control of androgen receptor (AR) protein steady-state levels. Taurus_UMD|evm.model.AC_000164.1.158 A4FV75 TM38A_BOVIN 100.000 0.993333 1.00334 TMEM38A - Trimeric intracellular cation channel type A - Bos taurus (Bovine) - TMEM38A gene Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Taurus_UMD|evm.model.AC_000164.1.159 Q3SZ97 SMIM7_BOVIN 100.000 0.972222 0.96 SMIM7 - Small integral membrane protein 7 precursor - Bos taurus (Bovine) - SMIM7 gene Taurus_UMD|evm.model.AC_000164.1.160 A5PK23 MED26_BOVIN 100.000 0.996667 1.00167 MED26 - Mediator of RNA polymerase II transcription subunit 26 - Bos taurus (Bovine) - MED26 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Taurus_UMD|evm.model.AC_000164.1.161 Q96K37 S35E1_HUMAN 96.373 0.932203 1.00732 SLC35E1 - Solute carrier family 35 member E1 - Homo sapiens (Human) - SLC35E1 gene Putative transporter. Taurus_UMD|evm.model.AC_000164.1.162 Q8IWX8 CHERP_HUMAN 97.162 0.997819 1.00109 CHERP - Calcium homeostasis endoplasmic reticulum protein - Homo sapiens (Human) - CHERP gene Involved in calcium homeostasis, growth and proliferation. Taurus_UMD|evm.model.AC_000164.1.163 Q9H6X5 CS044_HUMAN 74.627 0.99005 0.305936 C19orf44 - Uncharacterized protein C19orf44 - Homo sapiens (Human) - C19orf44 gene Taurus_UMD|evm.model.AC_000164.1.164 P30050 RL12_HUMAN 94.545 0.987952 1.00606 RPL12 - 60S ribosomal protein L12 - Homo sapiens (Human) - RPL12 gene Binds directly to 26S ribosomal RNA. Taurus_UMD|evm.model.AC_000164.1.165 Q2TBR8 CALR3_BOVIN 99.479 0.896956 1.11198 CALR3 - Calreticulin-3 precursor - Bos taurus (Bovine) - CALR3 gene During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity). Taurus_UMD|evm.model.AC_000164.1.166 Q9UBC2 EP15R_HUMAN 93.387 0.945115 1.0544 EPS15L1 - Epidermal growth factor receptor substrate 15-like 1 - Homo sapiens (Human) - EPS15L1 gene Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. Taurus_UMD|evm.model.AC_000164.1.167 Q9Y5W3 KLF2_HUMAN 99.038 0.449782 0.64507 KLF2 - Krueppel-like factor 2 - Homo sapiens (Human) - KLF2 gene Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758). Taurus_UMD|evm.model.AC_000164.1.169 Q9BXS5 AP1M1_HUMAN 100.000 0.995283 1.00236 AP1M1 - AP-1 complex subunit mu-1 - Homo sapiens (Human) - AP1M1 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Taurus_UMD|evm.model.AC_000164.1.170 Q5R9E5 FA32A_PONAB 100.000 0.982301 1.00893 FAM32A - Protein FAM32A - Pongo abelii (Sumatran orangutan) - FAM32A gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Taurus_UMD|evm.model.AC_000164.1.171 Q96Q77 CIB3_HUMAN 97.778 0.983516 0.973262 CIB3 - Calcium and integrin-binding family member 3 - Homo sapiens (Human) - CIB3 gene calcium ion binding, magnesium ion binding Taurus_UMD|evm.model.AC_000164.1.172 Q96JZ2 HSH2D_HUMAN 57.923 0.994169 0.974432 HSH2D - Hematopoietic SH2 domain-containing protein - Homo sapiens (Human) - HSH2D gene May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. Taurus_UMD|evm.model.AC_000164.1.173 A4FV54 RAB8A_BOVIN 100.000 0.990385 1.00483 RAB8A - Ras-related protein Rab-8A precursor - Bos taurus (Bovine) - RAB8A gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with MYO5B and RAB11A participates in epithelial cell polarization (By similarity). May be involved in ciliogenesis (By similarity). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (By similarity). Taurus_UMD|evm.model.AC_000164.1.174 Q01173 TPM1_XENLA 81.338 0.992982 1.00352 tpm1 - Tropomyosin alpha-1 chain - Xenopus laevis (African clawed frog) - tpm1 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Taurus_UMD|evm.model.AC_000164.1.176 Q9Y4A9 O10H1_HUMAN 77.193 0.327485 0.537736 OR10H1 - Olfactory receptor 10H1 - Homo sapiens (Human) - OR10H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000164.1.177 Q9GLL1 CP4F_SHEEP 81.636 0.996317 1.02841 CYP4F21 - Prostaglandin E2 omega-hydroxylase CYP4F21 precursor - Ovis aries (Sheep) - CYP4F21 gene A cytochrome P450 monooxygenase that catalyzes the omega-hydroxylation of prostaglandin E2. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Taurus_UMD|evm.model.AC_000164.1.178 Q9GLL1 CP4F_SHEEP 83.176 0.940541 1.05114 CYP4F21 - Prostaglandin E2 omega-hydroxylase CYP4F21 precursor - Ovis aries (Sheep) - CYP4F21 gene A cytochrome P450 monooxygenase that catalyzes the omega-hydroxylation of prostaglandin E2. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Taurus_UMD|evm.model.AC_000164.1.179 P78329 CP4F2_HUMAN 81.731 0.98855 1.00769 CYP4F2 - Cytochrome P450 4F2 precursor - Homo sapiens (Human) - CYP4F2 gene A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins (PubMed:18577768, PubMed:10833273, PubMed:10660572, PubMed:11997390, PubMed:17341693, PubMed:18574070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids. Displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs) (PubMed:18577768). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10660572, PubMed:17341693, PubMed:18574070). Plays a role in the oxidative inactivation of eicosanoids, including both proinflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs (PubMed:8026587, PubMed:9799565, PubMed:10833273, PubMed:10660572, PubMed:17341693, PubMed:18574070, PubMed:18577768). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids (PubMed:18065749). Converts monoepoxides of linoleic acid leukotoxin and isoleukotoxin to omega-hydroxylated metabolites (PubMed:15145985). Contributes to the degradation of very long-chain fatty acids (VLCFAs) by catalyzing successive omega-oxidations and chain shortening (PubMed:16547005, PubMed:18182499). Plays an important role in vitamin metabolism by chain shortening. Catalyzes omega-hydroxylation of the phytyl chain of tocopherols (forms of vitamin E), with preference for gamma-tocopherols over alpha-tocopherols, thus promoting retention of alpha-tocopherols in tissues (PubMed:11997390). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:19297519, PubMed:24138531). Taurus_UMD|evm.model.AC_000164.1.180 P78329 CP4F2_HUMAN 73.090 0.989673 1.11731 CYP4F2 - Cytochrome P450 4F2 precursor - Homo sapiens (Human) - CYP4F2 gene A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins (PubMed:18577768, PubMed:10833273, PubMed:10660572, PubMed:11997390, PubMed:17341693, PubMed:18574070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids. Displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs) (PubMed:18577768). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10660572, PubMed:17341693, PubMed:18574070). Plays a role in the oxidative inactivation of eicosanoids, including both proinflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs (PubMed:8026587, PubMed:9799565, PubMed:10833273, PubMed:10660572, PubMed:17341693, PubMed:18574070, PubMed:18577768). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids (PubMed:18065749). Converts monoepoxides of linoleic acid leukotoxin and isoleukotoxin to omega-hydroxylated metabolites (PubMed:15145985). Contributes to the degradation of very long-chain fatty acids (VLCFAs) by catalyzing successive omega-oxidations and chain shortening (PubMed:16547005, PubMed:18182499). Plays an important role in vitamin metabolism by chain shortening. Catalyzes omega-hydroxylation of the phytyl chain of tocopherols (forms of vitamin E), with preference for gamma-tocopherols over alpha-tocopherols, thus promoting retention of alpha-tocopherols in tissues (PubMed:11997390). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:19297519, PubMed:24138531). Taurus_UMD|evm.model.AC_000164.1.181 P78329 CP4F2_HUMAN 83.462 0.988571 1.00962 CYP4F2 - Cytochrome P450 4F2 precursor - Homo sapiens (Human) - CYP4F2 gene A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins (PubMed:18577768, PubMed:10833273, PubMed:10660572, PubMed:11997390, PubMed:17341693, PubMed:18574070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids. Displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs) (PubMed:18577768). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10660572, PubMed:17341693, PubMed:18574070). Plays a role in the oxidative inactivation of eicosanoids, including both proinflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs (PubMed:8026587, PubMed:9799565, PubMed:10833273, PubMed:10660572, PubMed:17341693, PubMed:18574070, PubMed:18577768). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids (PubMed:18065749). Converts monoepoxides of linoleic acid leukotoxin and isoleukotoxin to omega-hydroxylated metabolites (PubMed:15145985). Contributes to the degradation of very long-chain fatty acids (VLCFAs) by catalyzing successive omega-oxidations and chain shortening (PubMed:16547005, PubMed:18182499). Plays an important role in vitamin metabolism by chain shortening. Catalyzes omega-hydroxylation of the phytyl chain of tocopherols (forms of vitamin E), with preference for gamma-tocopherols over alpha-tocopherols, thus promoting retention of alpha-tocopherols in tissues (PubMed:11997390). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:19297519, PubMed:24138531). Taurus_UMD|evm.model.AC_000164.1.182 Q9GLL1 CP4F_SHEEP 92.000 0.216216 0.210227 CYP4F21 - Prostaglandin E2 omega-hydroxylase CYP4F21 precursor - Ovis aries (Sheep) - CYP4F21 gene A cytochrome P450 monooxygenase that catalyzes the omega-hydroxylation of prostaglandin E2. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Taurus_UMD|evm.model.AC_000164.1.183 P51871 CP4F6_RAT 79.079 0.992352 0.973929 Cyp4f6 - Cytochrome P450 4F6 - Rattus norvegicus (Rat) - Cyp4f6 gene inflammatory response, leukotriene metabolic process Taurus_UMD|evm.model.AC_000164.1.184 Q6NT55 CP4FN_HUMAN 93.032 0.996241 1.00188 CYP4F22 - Cytochrome P450 4F22 - Homo sapiens (Human) - CYP4F22 gene A cytochrome P450 monooxygenase involved in epidermal ceramide biosynthesis. Hydroxylates the terminal carbon (omega-hydroxylation) of ultra-long-chain fatty acyls (C28-C36) prior to ceramide synthesis (PubMed:26056268). Contributes to the synthesis of three classes of omega-hydroxy-ultra-long chain fatty acylceramides having sphingosine, 6-hydroxysphingosine and phytosphingosine bases, all major lipid components that underlie the permeability barrier of the stratum corneum (PubMed:26056268). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:26056268). Taurus_UMD|evm.model.AC_000164.1.185 A6QQ91 RASL3_BOVIN 99.896 0.63082 1.50692 RASAL3 - RAS protein activator like-3 - Bos taurus (Bovine) - RASAL3 gene Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. Taurus_UMD|evm.model.AC_000164.1.186 O95785 WIZ_HUMAN 79.771 0.392518 1.14961 WIZ - Protein Wiz - Homo sapiens (Human) - WIZ gene May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). Taurus_UMD|evm.model.AC_000164.1.187 Q9ULX6 AKP8L_HUMAN 90.909 0.996909 1.00155 AKAP8L - A-kinase anchor protein 8-like - Homo sapiens (Human) - AKAP8L gene Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). Taurus_UMD|evm.model.AC_000164.1.188 O43823 AKAP8_HUMAN 84.006 0.997076 0.988439 AKAP8 - A-kinase anchor protein 8 - Homo sapiens (Human) - AKAP8 gene Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). Taurus_UMD|evm.model.AC_000164.1.189 O60885 BRD4_HUMAN 96.730 0.527338 1.02056 BRD4 - Bromodomain-containing protein 4 - Homo sapiens (Human) - BRD4 gene Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:23589332, PubMed:23317504, PubMed:22334664). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:23589332, PubMed:19596240, PubMed:16109377, PubMed:16109376, PubMed:24360279). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). Taurus_UMD|evm.model.AC_000164.1.190 Q9H6B9 EPHX3_HUMAN 89.722 0.99446 1.00278 EPHX3 - Epoxide hydrolase 3 - Homo sapiens (Human) - EPHX3 gene Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin. Taurus_UMD|evm.model.AC_000164.1.191 Q9UM47 NOTC3_HUMAN 93.054 0.980712 1.00517 NOTCH3 - Neurogenic locus notch homolog protein 3 precursor - Homo sapiens (Human) - NOTCH3 gene Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Taurus_UMD|evm.model.AC_000164.1.192 Q920A7 AFG31_MOUSE 70.021 0.950226 0.560203 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Taurus_UMD|evm.model.AC_000164.1.193 A6QQT9 HACL2_BOVIN 100.000 0.99684 1.00158 ILVBL - 2-hydroxyacyl-CoA lyase 2 - Bos taurus (Bovine) - ILVBL gene Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway. Taurus_UMD|evm.model.AC_000164.1.194 D3ZZN9 SYDE1_RAT 89.011 0.787572 0.941497 Syde1 - Rho GTPase-activating protein SYDE1 - Rattus norvegicus (Rat) - Syde1 gene GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1. Taurus_UMD|evm.model.AC_000164.1.195 O60431 OR1I1_HUMAN 84.507 0.985915 0.2 OR1I1 - Olfactory receptor 1I1 - Homo sapiens (Human) - OR1I1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000164.1.196 P31944 CASPE_HUMAN 80.252 0.933071 1.04959 CASP14 - Caspase-14 precursor - Homo sapiens (Human) - CASP14 gene Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736). Taurus_UMD|evm.model.AC_000164.1.197 Q2YDN4 CC105_BOVIN 100.000 0.996008 1.002 CCDC105 - Coiled-coil domain-containing protein 105 - Bos taurus (Bovine) - CCDC105 gene Taurus_UMD|evm.model.AC_000164.1.198 Q9N1R2 EAA4_CANLF 80.531 0.996086 0.906028 SLC1A6 - Excitatory amino acid transporter 4 - Canis lupus familiaris (Dog) - SLC1A6 gene Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. Taurus_UMD|evm.model.AC_000164.1.199 Q93062 RBPMS_HUMAN 97.959 0.96 0.255102 RBPMS - RNA-binding protein with multiple splicing - Homo sapiens (Human) - RBPMS gene Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403). Taurus_UMD|evm.model.AC_000164.1.202 O76100 OR7AA_HUMAN 70.500 0.99005 0.650485 OR7A10 - Olfactory receptor 7A10 - Homo sapiens (Human) - OR7A10 gene Odorant receptor. Taurus_UMD|evm.model.AC_000164.1.204 Q58CS8 GNPTG_BOVIN 97.688 0.839024 0.669935 GNPTG - N-acetylglucosamine-1-phosphotransferase subunit gamma precursor - Bos taurus (Bovine) - GNPTG gene Non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors (By similarity). Taurus_UMD|evm.model.AC_000164.1.205 Q2Q421 AGRE2_CANLF 76.667 0.776316 0.0915663 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Canis lupus familiaris (Dog) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Taurus_UMD|evm.model.AC_000164.1.206 Q2Q426 AGRE2_MACMU 71.338 0.993651 0.383212 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Macaca mulatta (Rhesus macaque) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Taurus_UMD|evm.model.AC_000164.1.207 Q2Q421 AGRE2_CANLF 56.180 0.345098 0.307229 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Canis lupus familiaris (Dog) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Taurus_UMD|evm.model.AC_000164.1.210 Q9UHX3 AGRE2_HUMAN 59.085 0.862577 0.990279 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Homo sapiens (Human) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242). Taurus_UMD|evm.model.AC_000164.1.211 Q2Q421 AGRE2_CANLF 76.786 0.528846 0.125301 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Canis lupus familiaris (Dog) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Taurus_UMD|evm.model.AC_000164.1.212 Q8SQA4 AGRE5_BOVIN 100.000 0.0426065 1.63079 ADGRE5 - Adhesion G protein-coupled receptor E5 precursor - Bos taurus (Bovine) - ADGRE5 gene Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. Taurus_UMD|evm.model.AC_000164.1.213 Q9EQU5 SET_MOUSE 80.469 0.334302 1.19031 Set - Protein SET - Mus musculus (Mouse) - Set gene Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher (By similarity). Taurus_UMD|evm.model.AC_000164.1.214 Q2Q426 AGRE2_MACMU 96.667 0.0341981 1.03163 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Macaca mulatta (Rhesus macaque) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Taurus_UMD|evm.model.AC_000164.1.215 Q8SQA4 AGRE5_BOVIN 50.718 0.840336 0.324251 ADGRE5 - Adhesion G protein-coupled receptor E5 precursor - Bos taurus (Bovine) - ADGRE5 gene Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. Taurus_UMD|evm.model.AC_000164.1.216 Q2Q421 AGRE2_CANLF 71.240 0.904077 0.50241 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Canis lupus familiaris (Dog) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Taurus_UMD|evm.model.AC_000164.1.217 Q2Q421 AGRE2_CANLF 74.444 0.706349 0.151807 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Canis lupus familiaris (Dog) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Taurus_UMD|evm.model.AC_000164.1.218 Q2Q426 AGRE2_MACMU 94.737 0.455285 0.149635 ADGRE2 - Adhesion G protein-coupled receptor E2 precursor - Macaca mulatta (Rhesus macaque) - ADGRE2 gene Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Taurus_UMD|evm.model.AC_000164.1.219 Q9EQU5 SET_MOUSE 89.744 0.640884 0.626298 Set - Protein SET - Mus musculus (Mouse) - Set gene Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher (By similarity). Taurus_UMD|evm.model.AC_000164.1.220 Q96JL9 ZN333_HUMAN 65.988 0.987069 1.04662 ZNF333 - Zinc finger protein 333 - Homo sapiens (Human) - ZNF333 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.221 Q9BY15 AGRE3_HUMAN 70.813 0.979066 0.952454 ADGRE3 - Adhesion G protein-coupled receptor E3 precursor - Homo sapiens (Human) - ADGRE3 gene Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils. Taurus_UMD|evm.model.AC_000164.1.222 Q6ZS10 CL17A_HUMAN 59.756 0.916667 0.920635 CLEC17A - C-type lectin domain family 17, member A - Homo sapiens (Human) - CLEC17A gene Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues. Taurus_UMD|evm.model.AC_000164.1.223 Q02368 NDUB7_BOVIN 100.000 0.985507 1.0073 NDUFB7 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 - Bos taurus (Bovine) - NDUFB7 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000164.1.224 Q3ZCD7 TECR_BOVIN 100.000 0.993528 1.00325 TECR - Very-long-chain enoyl-CoA reductase - Bos taurus (Bovine) - TECR gene Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (By similarity). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (By similarity). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (By similarity). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (By similarity). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (By similarity). Taurus_UMD|evm.model.AC_000164.1.225 Q3MI00 DNJB1_BOVIN 100.000 0.994135 1.00294 DNAJB1 - DnaJ homolog subfamily B member 1 - Bos taurus (Bovine) - DNAJB1 gene Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Taurus_UMD|evm.model.AC_000164.1.226 O14908 GIPC1_HUMAN 98.198 0.994012 1.003 GIPC1 - PDZ domain-containing protein GIPC1 - Homo sapiens (Human) - GIPC1 gene May be involved in G protein-linked signaling. Taurus_UMD|evm.model.AC_000164.1.227 P34995 PE2R1_HUMAN 87.224 0.918552 1.0995 PTGER1 - Prostaglandin E2 receptor EP1 subtype - Homo sapiens (Human) - PTGER1 gene Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues. Taurus_UMD|evm.model.AC_000164.1.228 A1A4I4 PKN1_BOVIN 99.787 0.98633 1.00742 PKN1 - Serine/threonine-protein kinase N1 - Bos taurus (Bovine) - PKN1 gene PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. Taurus_UMD|evm.model.AC_000164.1.229 Q8VDW0 DX39A_MOUSE 97.892 0.995327 1.00234 Ddx39a - ATP-dependent RNA helicase DDX39A - Mus musculus (Mouse) - Ddx39a gene Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus (By similarity). Taurus_UMD|evm.model.AC_000164.1.230 Q8SQA4 AGRE5_BOVIN 83.918 0.997585 1.12807 ADGRE5 - Adhesion G protein-coupled receptor E5 precursor - Bos taurus (Bovine) - ADGRE5 gene Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. Taurus_UMD|evm.model.AC_000164.1.231 O97831 AGRL1_BOVIN 99.932 0.998642 1.00068 ADGRL1 - Adhesion G protein-coupled receptor L1 precursor - Bos taurus (Bovine) - ADGRL1 gene Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). Taurus_UMD|evm.model.AC_000164.1.232 Q17QJ0 ASF1B_BOVIN 100.000 0.990148 1.00495 ASF1B - Histone chaperone ASF1B - Bos taurus (Bovine) - ASF1B gene Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (By similarity). Taurus_UMD|evm.model.AC_000164.1.233 P00517 KAPCA_BOVIN 100.000 0.994318 1.00285 PRKACA - cAMP-dependent protein kinase catalytic subunit alpha - Bos taurus (Bovine) - PRKACA gene Phosphorylates a large number of substrates in the cytoplasm and the nucleus (By similarity). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (By similarity). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (By similarity). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis (By similarity). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA. Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (By similarity). Taurus_UMD|evm.model.AC_000164.1.234 Q8CF25 CS067_MOUSE 87.189 0.777778 1.19601 UPF0575 protein C19orf67 homolog - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000164.1.235 Q96FF7 MISP3_HUMAN 82.870 0.986239 0.995434 MISP3 - Uncharacterized protein MISP3 - Homo sapiens (Human) - MISP3 gene Taurus_UMD|evm.model.AC_000164.1.236 A6NDB9 PALM3_HUMAN 67.031 0.693316 1.13373 PALM3 - Paralemmin-3 precursor - Homo sapiens (Human) - PALM3 gene ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. Taurus_UMD|evm.model.AC_000164.1.237 Q6UWB1 I27RA_HUMAN 73.134 0.915773 1.02673 IL27RA - Interleukin-27 receptor subunit alpha precursor - Homo sapiens (Human) - IL27RA gene Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. Taurus_UMD|evm.model.AC_000164.1.238 P11953 RELX_SQUAC 90.909 0.154412 2.51852 Relaxin - Squalus acanthias (Spiny dogfish) Taurus_UMD|evm.model.AC_000164.1.239 P22670 RFX1_HUMAN 92.889 0.527059 0.434116 RFX1 - MHC class II regulatory factor RFX1 - Homo sapiens (Human) - RFX1 gene Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. Taurus_UMD|evm.model.AC_000164.1.240 P22670 RFX1_HUMAN 88.182 0.951754 0.232891 RFX1 - MHC class II regulatory factor RFX1 - Homo sapiens (Human) - RFX1 gene Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. Taurus_UMD|evm.model.AC_000164.1.241 P22670 RFX1_HUMAN 94.638 0.994652 0.382022 RFX1 - MHC class II regulatory factor RFX1 - Homo sapiens (Human) - RFX1 gene Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. Taurus_UMD|evm.model.AC_000164.1.242 Q3SZD5 DCA15_BOVIN 100.000 0.996672 1.00167 DCAF15 - DDB1- and CUL4-associated factor 15 - Bos taurus (Bovine) - DCAF15 gene Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins. The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3. May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells. Taurus_UMD|evm.model.AC_000164.1.243 Q6PEZ8 PONL1_HUMAN 91.009 0.765993 1.16016 PODNL1 - Podocan-like protein 1 precursor - Homo sapiens (Human) - PODNL1 gene extracellular space Taurus_UMD|evm.model.AC_000164.1.244 Q6P1N0 C2D1A_HUMAN 91.483 0.997899 1.00105 CC2D1A - Coiled-coil and C2 domain-containing protein 1A - Homo sapiens (Human) - CC2D1A gene Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. Taurus_UMD|evm.model.AC_000164.1.245 Q0VDD7 BRME1_HUMAN 47.411 0.938193 0.944611 BRME1 - Break repair meiotic recombinase recruitment factor 1 - Homo sapiens (Human) - BRME1 gene Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. Taurus_UMD|evm.model.AC_000164.1.246 P60323 NANO3_HUMAN 84.615 0.818713 0.988439 NANOS3 - Nanos homolog 3 - Homo sapiens (Human) - NANOS3 gene Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. Taurus_UMD|evm.model.AC_000164.1.247 Q0VDD7 BRME1_HUMAN 67.073 0.623077 0.194611 BRME1 - Break repair meiotic recombinase recruitment factor 1 - Homo sapiens (Human) - BRME1 gene Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. Taurus_UMD|evm.model.AC_000164.1.248 Q5EA37 CC130_BOVIN 99.695 0.98494 0.83 CCDC130 - Coiled-coil domain-containing protein 130 - Bos taurus (Bovine) - CCDC130 gene post-mRNA release spliceosomal complex, U2-type spliceosomal complex, RNA splicing Taurus_UMD|evm.model.AC_000164.1.249 Q2NL31 MTNA_BOVIN 100.000 0.994429 1.00279 MRI1 - Methylthioribose-1-phosphate isomerase - Bos taurus (Bovine) - MRI1 gene Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Taurus_UMD|evm.model.AC_000164.1.250 Q148I0 L10K_BOVIN 100.000 0.960396 1.03061 Leydig cell tumor 10 kDa protein homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000164.1.251 Q9H7M6 ZSWM4_HUMAN 96.477 0.537489 1.11931 ZSWIM4 - Zinc finger SWIM domain-containing protein 4 - Homo sapiens (Human) - ZSWIM4 gene Cul2-RING ubiquitin ligase complex, regulation of axon guidance Taurus_UMD|evm.model.AC_000164.1.252 P13994 CC130_HUMAN 94.000 0.379845 0.325758 CCDC130 - Coiled-coil domain-containing protein 130 - Homo sapiens (Human) - CCDC130 gene post-mRNA release spliceosomal complex, U2-type spliceosomal complex, response to virus, RNA splicing Taurus_UMD|evm.model.AC_000164.1.254 O00555 CAC1A_HUMAN 98.980 0.757812 0.0510774 CACNA1A - Voltage-dependent P/Q-type calcium channel subunit alpha-1A - Homo sapiens (Human) - CACNA1A gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP). Taurus_UMD|evm.model.AC_000164.1.255 O00555 CAC1A_HUMAN 96.650 0.891476 0.90822 CACNA1A - Voltage-dependent P/Q-type calcium channel subunit alpha-1A - Homo sapiens (Human) - CACNA1A gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP). Taurus_UMD|evm.model.AC_000164.1.256 Q9BTL4 IER2_HUMAN 82.589 0.991031 1 IER2 - Immediate early response gene 2 protein - Homo sapiens (Human) - IER2 gene DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713). Taurus_UMD|evm.model.AC_000164.1.257 O60499 STX10_HUMAN 85.551 0.992424 1.06024 STX10 - Syntaxin-10 - Homo sapiens (Human) - STX10 gene SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Taurus_UMD|evm.model.AC_000164.1.258 Q96RE7 NACC1_HUMAN 90.977 0.996248 1.01139 NACC1 - Nucleus accumbens-associated protein 1 - Homo sapiens (Human) - NACC1 gene Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Taurus_UMD|evm.model.AC_000164.1.259 Q9NXH9 TRM1_HUMAN 88.943 0.651113 1.43096 TRMT1 - tRNA (guanine(26)-N(2))-dimethyltransferase - Homo sapiens (Human) - TRMT1 gene Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. Taurus_UMD|evm.model.AC_000164.1.262 Q14938 NFIX_HUMAN 99.036 0.938776 0.878486 NFIX - Nuclear factor 1 X-type - Homo sapiens (Human) - NFIX gene Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Taurus_UMD|evm.model.AC_000164.1.263 A1A4P4 G45IP_BOVIN 100.000 0.991031 1.0045 GADD45GIP1 - Growth arrest and DNA damage-inducible proteins-interacting protein 1 - Bos taurus (Bovine) - GADD45GIP1 gene Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. Taurus_UMD|evm.model.AC_000164.1.264 A3KMV2 RD23A_BOVIN 99.725 0.994505 1.00552 RAD23A - UV excision repair protein RAD23 homolog A - Bos taurus (Bovine) - RAD23A gene Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (By similarity). Taurus_UMD|evm.model.AC_000164.1.265 P52193 CALR_BOVIN 99.760 0.995215 1.0024 CALR - Calreticulin precursor - Bos taurus (Bovine) - CALR gene Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). Taurus_UMD|evm.model.AC_000164.1.266 Q5RFA2 SYFA_PONAB 94.685 0.996071 1.00197 FARSA - Phenylalanine--tRNA ligase alpha subunit - Pongo abelii (Sumatran orangutan) - FARSA gene cytoplasm, phenylalanine-tRNA ligase complex, phenylalanine-tRNA ligase activity, phenylalanyl-tRNA aminoacylation, protein heterotetramerization Taurus_UMD|evm.model.AC_000164.1.267 Q6PIF2 SYCE2_HUMAN 75.882 0.982558 0.788991 SYCE2 - Synaptonemal complex central element protein 2 - Homo sapiens (Human) - SYCE2 gene Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity). Taurus_UMD|evm.model.AC_000164.1.268 Q2KHZ9 GCDH_BOVIN 100.000 0.995444 1.00228 GCDH - Glutaryl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - GCDH gene Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor (By similarity). Taurus_UMD|evm.model.AC_000164.1.269 Q60793 KLF4_MOUSE 83.673 0.269444 0.745342 Klf4 - Krueppel-like factor 4 - Mus musculus (Mouse) - Klf4 gene Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity). Taurus_UMD|evm.model.AC_000164.1.270 P56541 DNS2A_BOVIN 99.726 0.994536 1.00274 DNASE2 - Deoxyribonuclease-2-alpha precursor - Bos taurus (Bovine) - DNASE2 gene Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells (By similarity). Taurus_UMD|evm.model.AC_000164.1.271 Q9Y2H9 MAST1_HUMAN 92.444 0.969144 1.01146 MAST1 - Microtubule-associated serine/threonine-protein kinase 1 - Homo sapiens (Human) - MAST1 gene Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). Taurus_UMD|evm.model.AC_000164.1.272 Q4TUC0 RTBDN_CANLF 62.176 0.926702 0.856502 RTBDN - Retbindin precursor - Canis lupus familiaris (Dog) - RTBDN gene Riboflavin-binding protein which might have a role in retinal flavin transport. Taurus_UMD|evm.model.AC_000164.1.273 Q2TBT5 RNH2A_BOVIN 100.000 0.993333 1.00334 RNASEH2A - Ribonuclease H2 subunit A - Bos taurus (Bovine) - RNASEH2A gene Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. Taurus_UMD|evm.model.AC_000164.1.274 A0A1W2PP97 THSD8_HUMAN 77.586 0.982906 1.01739 THSD8 - Thrombospondin type-1 domain-containing protein 8 precursor - Homo sapiens (Human) - THSD8 gene Taurus_UMD|evm.model.AC_000164.1.275 Q9BGI3 PRDX2_BOVIN 100.000 0.99 1.00503 PRDX2 - Peroxiredoxin-2 - Bos taurus (Bovine) - PRDX2 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Taurus_UMD|evm.model.AC_000164.1.276 Q0VBZ5 JUNB_BOVIN 100.000 0.994253 1.00288 JUNB - Transcription factor jun-B - Bos taurus (Bovine) - JUNB gene Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3' (By similarity). Taurus_UMD|evm.model.AC_000164.1.277 Q96ED9 HOOK2_HUMAN 90.821 0.997211 0.997218 HOOK2 - Protein Hook homolog 2 - Homo sapiens (Human) - HOOK2 gene Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Taurus_UMD|evm.model.AC_000164.1.278 Q8NFU1 BEST2_HUMAN 84.961 0.996101 1.00786 BEST2 - Bestrophin-2 - Homo sapiens (Human) - BEST2 gene Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Taurus_UMD|evm.model.AC_000164.1.279 O43681 GET3_HUMAN 100.000 0.994269 1.00287 GET3 - ATPase GET3 - Homo sapiens (Human) - GET3 gene ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling. Taurus_UMD|evm.model.AC_000164.1.280 Q99LG2 TNPO2_MOUSE 99.549 0.815087 1.22548 Tnpo2 - Transportin-2 - Mus musculus (Mouse) - Tnpo2 gene Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Taurus_UMD|evm.model.AC_000164.1.281 Q2T9T9 FBXW9_BOVIN 99.563 0.995643 1.00218 FBXW9 - F-box/WD repeat-containing protein 9 - Bos taurus (Bovine) - FBXW9 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000164.1.282 A0A1W2PPG7 GBG14_HUMAN 77.778 0.972603 1.05797 GNG14 - Putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 - Homo sapiens (Human) - GNG14 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Taurus_UMD|evm.model.AC_000164.1.283 Q6EWQ6 DHYS_BOVIN 100.000 0.994595 1.00271 DHPS - Deoxyhypusine synthase - Bos taurus (Bovine) - DHPS gene Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. Taurus_UMD|evm.model.AC_000164.1.284 Q9BRX9 WDR83_HUMAN 95.238 0.993671 1.00317 WDR83 - WD repeat domain-containing protein 83 - Homo sapiens (Human) - WDR83 gene Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000164.1.285 Q2M2T6 ASTER_BOVIN 100.000 0.981308 1.00943 WDR83OS - PAT complex subunit Asterix - Bos taurus (Bovine) - WDR83OS gene Component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. WDR83OS/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS/Asterix. WDR83OS/Asterix associates with the first transmembrane domain (TMD1) of the nascent chain, independently of the N-glycosylation of the chain and irrespective of the amino acid sequence and transmembrane topology of TMD1. The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which TMD1 binds. Taurus_UMD|evm.model.AC_000164.1.286 Q29451 MA2B1_BOVIN 100.000 0.998 1.001 MAN2B1 - Lysosomal alpha-mannosidase precursor - Bos taurus (Bovine) - MAN2B1 gene Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Taurus_UMD|evm.model.AC_000164.1.287 Q8N972 ZN709_HUMAN 60.526 0.974757 0.803432 ZNF709 - Zinc finger protein 709 - Homo sapiens (Human) - ZNF709 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.289 Q8TBZ8 ZN564_HUMAN 54.007 0.740933 0.698011 ZNF564 - Zinc finger protein 564 - Homo sapiens (Human) - ZNF564 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.290 Q8WXI7 MUC16_HUMAN 63.502 0.201257 0.515475 MUC16 - Mucin-16 - Homo sapiens (Human) - MUC16 gene Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Taurus_UMD|evm.model.AC_000164.1.291 Q3ZCI9 TCPQ_BOVIN 97.810 0.996337 0.99635 CCT8 - T-complex protein 1 subunit theta - Bos taurus (Bovine) - CCT8 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Taurus_UMD|evm.model.AC_000164.1.292 Q96PQ6 ZN317_HUMAN 86.477 0.959872 1.04706 ZNF317 - Zinc finger protein 317 - Homo sapiens (Human) - ZNF317 gene May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation. Taurus_UMD|evm.model.AC_000164.1.293 Q32PG5 SCND1_BOVIN 62.500 0.5 0.797753 SCAND1 - SCAN domain-containing protein 1 - Bos taurus (Bovine) - SCAND1 gene May regulate transcriptional activity. Taurus_UMD|evm.model.AC_000164.1.294 Q3MHV9 SERC1_BOVIN 93.516 0.995025 0.887417 SERINC1 - Serine incorporator 1 - Bos taurus (Bovine) - SERINC1 gene Enhances the incorporation of serine into phosphatidylserine and sphingolipids. Taurus_UMD|evm.model.AC_000164.1.295 Q32M78 ZN699_HUMAN 84.112 0.996694 0.942368 ZNF699 - Zinc finger protein 699 - Homo sapiens (Human) - ZNF699 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.296 Q13360 ZN177_HUMAN 70.520 0.875639 1.22037 ZNF177 - Zinc finger protein 177 - Homo sapiens (Human) - ZNF177 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.297 A8MTY0 ZN724_HUMAN 53.659 0.317708 0.620355 ZNF724 - Zinc finger protein 724 - Homo sapiens (Human) - ZNF724 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.298 A2T812 ZN287_PONPY 59.623 0.981413 0.353482 ZNF287 - Zinc finger protein 287 - Pongo pygmaeus (Bornean orangutan) - ZNF287 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.299 Q96MR9 ZN560_HUMAN 61.458 0.683453 0.175949 ZNF560 - Zinc finger protein 560 - Homo sapiens (Human) - ZNF560 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.300 Q13360 ZN177_HUMAN 50.340 0.953333 0.31185 ZNF177 - Zinc finger protein 177 - Homo sapiens (Human) - ZNF177 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.301 Q32PG9 FXL12_BOVIN 99.693 0.993884 1.00307 FBXL12 - F-box/LRR-repeat protein 12 - Bos taurus (Bovine) - FBXL12 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity). Taurus_UMD|evm.model.AC_000164.1.302 Q791B0 UBL5_PSAOB 100.000 0.94 0.684932 UBL5 - Ubiquitin-like protein 5 - Psammomys obesus (Fat sand rat) - UBL5 gene Taurus_UMD|evm.model.AC_000164.1.303 Q5BIN5 PIN1_BOVIN 100.000 0.987805 1.00613 PIN1 - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 - Bos taurus (Bovine) - PIN1 gene Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes. Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner. Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN. May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells. Taurus_UMD|evm.model.AC_000164.1.304 Q8BM13 NOE2_MOUSE 98.614 0.901879 1.0692 Olfm2 - Noelin-2 precursor - Mus musculus (Mouse) - Olfm2 gene Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation (By similarity). TGF-beta induces expression and nuclear translocation of OLFM2 where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (By similarity). Plays a role in AMPAR complex organization (PubMed:25218043). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity). Taurus_UMD|evm.model.AC_000164.1.305 P25940 CO5A3_HUMAN 85.633 0.998845 0.99255 COL5A3 - Collagen alpha-3(V) chain precursor - Homo sapiens (Human) - COL5A3 gene Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Taurus_UMD|evm.model.AC_000164.1.306 Q9N126 RDH8_BOVIN 100.000 0.99361 1.00321 RDH8 - Retinol dehydrogenase 8 - Bos taurus (Bovine) - RDH8 gene Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. Taurus_UMD|evm.model.AC_000164.1.307 P01024 CO3_HUMAN 38.530 0.984366 1 C3 - Complement C3 precursor - Homo sapiens (Human) - C3 gene C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Taurus_UMD|evm.model.AC_000164.1.308 Q32L09 SHFL_BOVIN 99.655 0.993127 1.00345 SHFL - Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog - Bos taurus (Bovine) - SHFL gene Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses and cellular genes. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site (By similarity). May exhibit antiviral activity (By similarity). Taurus_UMD|evm.model.AC_000164.1.309 Q8NI99 ANGL6_HUMAN 88.326 0.961538 0.995745 ANGPTL6 - Angiopoietin-related protein 6 precursor - Homo sapiens (Human) - ANGPTL6 gene May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure. Taurus_UMD|evm.model.AC_000164.1.310 Q91YU8 SSF1_MOUSE 82.713 0.546218 1.77234 Ppan - Suppressor of SWI4 1 homolog - Mus musculus (Mouse) - Ppan gene May have a role in cell growth. Taurus_UMD|evm.model.AC_000164.1.311 O75821 EIF3G_HUMAN 100.000 0.993769 1.00313 EIF3G - Eukaryotic translation initiation factor 3 subunit G - Homo sapiens (Human) - EIF3G gene RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. Taurus_UMD|evm.model.AC_000164.1.312 Q24K09 DNMT1_BOVIN 100.000 0.978723 1.0211 DNMT1 - DNA (cytosine-5)-methyltransferase 1 - Bos taurus (Bovine) - DNMT1 gene Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. Promotes tumor growth. Taurus_UMD|evm.model.AC_000164.1.313 O95136 S1PR2_HUMAN 88.385 0.994334 1 S1PR2 - Sphingosine 1-phosphate receptor 2 - Homo sapiens (Human) - S1PR2 gene Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). Taurus_UMD|evm.model.AC_000164.1.314 Q32PI6 RM04_BOVIN 100.000 0.99322 1.0034 MRPL4 - 39S ribosomal protein L4, mitochondrial - Bos taurus (Bovine) - MRPL4 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000164.1.315 Q95132 ICAM1_BOVIN 79.762 0.752252 0.414953 ICAM1 - Intercellular adhesion molecule 1 precursor - Bos taurus (Bovine) - ICAM1 gene ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Taurus_UMD|evm.model.AC_000164.1.316 Q95132 ICAM1_BOVIN 99.414 0.774242 1.23364 ICAM1 - Intercellular adhesion molecule 1 precursor - Bos taurus (Bovine) - ICAM1 gene ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Taurus_UMD|evm.model.AC_000164.1.317 Q9ERM2 ICAM4_MOUSE 70.161 0.925094 1.01908 Icam4 - Intercellular adhesion molecule 4 precursor - Mus musculus (Mouse) - Icam4 gene Adhesion molecule that binds to leukocyte adhesion LFA-1 protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins (By similarity). Isoform 2 may modulate binding of membrane-associated ICAM4. Taurus_UMD|evm.model.AC_000164.1.318 Q9UMF0 ICAM5_HUMAN 88.528 0.997833 0.998918 ICAM5 - Intercellular adhesion molecule 5 precursor - Homo sapiens (Human) - ICAM5 gene ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). Taurus_UMD|evm.model.AC_000164.1.319 P0C6A0 ZGLP1_HUMAN 68.333 0.835766 1.01107 ZGLP1 - GATA-type zinc finger protein 1 - Homo sapiens (Human) - ZGLP1 gene Transcriptional regulator that plays a key role in germ cell development. Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry. Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells. Regulates expression of STRA8, a central downstream effector for the meiotic program. Acts independently of retinoic acid (RA). In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase. Taurus_UMD|evm.model.AC_000164.1.320 Q05B51 FDX2_BOVIN 100.000 0.989305 1.00538 FDX2 - Ferredoxin-2, mitochondrial precursor - Bos taurus (Bovine) - FDX2 gene Essential for heme A and Fe/S protein biosynthesis. Taurus_UMD|evm.model.AC_000164.1.321 Q8IY67 RAVR1_HUMAN 95.188 0.628458 1.25248 RAVER1 - Ribonucleoprotein PTB-binding 1 - Homo sapiens (Human) - RAVER1 gene Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). Taurus_UMD|evm.model.AC_000164.1.322 Q28125 ICAM3_BOVIN 99.265 0.99633 1.00184 ICAM3 - Intercellular adhesion molecule 3 precursor - Bos taurus (Bovine) - ICAM3 gene ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages. Taurus_UMD|evm.model.AC_000164.1.323 P29597 TYK2_HUMAN 82.269 0.998316 1.00084 TYK2 - Non-receptor tyrosine-protein kinase TYK2 - Homo sapiens (Human) - TYK2 gene Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Taurus_UMD|evm.model.AC_000164.1.324 Q5EAC6 CDC37_BOVIN 68.129 0.993243 0.778947 CDC37 - Hsp90 co-chaperone Cdc37 - Bos taurus (Bovine) - CDC37 gene Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity. Taurus_UMD|evm.model.AC_000164.1.325 O89084 PDE4A_MOUSE 95.604 0.459184 0.232227 Pde4a - cAMP-specific 3',5'-cyclic phosphodiesterase 4A - Mus musculus (Mouse) - Pde4a gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Taurus_UMD|evm.model.AC_000164.1.326 P27815 PDE4A_HUMAN 85.792 0.895911 0.910835 PDE4A - cAMP-specific 3',5'-cyclic phosphodiesterase 4A - Homo sapiens (Human) - PDE4A gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Taurus_UMD|evm.model.AC_000164.1.327 Q684M4 KEAP1_PIG 99.038 0.9968 1.0016 KEAP1 - Kelch-like ECH-associated protein 1 - Sus scrofa (Pig) - KEAP1 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes. In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2. The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (By similarity). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (By similarity). Taurus_UMD|evm.model.AC_000164.1.328 Q684M3 S1PR5_PIG 88.722 0.995 1.00503 S1PR5 - Sphingosine 1-phosphate receptor 5 - Sus scrofa (Pig) - S1PR5 gene Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/O)alpha and G(12) subclass of heteromeric G-proteins (By similarity). Taurus_UMD|evm.model.AC_000164.1.329 Q684M2 ATG4D_PIG 94.503 0.995772 1.00853 ATG4D - Cysteine protease ATG4D - Sus scrofa (Pig) - ATG4D gene Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Taurus_UMD|evm.model.AC_000164.1.330 Q0V8M0 KRI1_BOVIN 100.000 0.997167 1.00142 KRI1 - Protein KRI1 homolog - Bos taurus (Bovine) - KRI1 gene 90S preribosome, nucleolus, endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000164.1.331 Q29RV0 CDN2D_BOVIN 100.000 0.988024 1.00602 CDKN2D - Cyclin-dependent kinase 4 inhibitor D - Bos taurus (Bovine) - CDKN2D gene Interacts strongly with CDK4 and CDK6 and inhibits them. Taurus_UMD|evm.model.AC_000164.1.332 Q3SYW1 AP1M2_BOVIN 100.000 0.995283 1.00236 AP1M2 - AP-1 complex subunit mu-2 - Bos taurus (Bovine) - AP1M2 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Taurus_UMD|evm.model.AC_000164.1.333 A5D7H3 CTL2_BOVIN 99.713 0.987234 0.998584 SLC44A2 - Choline transporter-like protein 2 - Bos taurus (Bovine) - SLC44A2 gene Choline transporter. Taurus_UMD|evm.model.AC_000164.1.334 Q12906 ILF3_HUMAN 94.667 0.99777 1.00336 ILF3 - Interleukin enhancer-binding factor 3 - Homo sapiens (Human) - ILF3 gene RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). Taurus_UMD|evm.model.AC_000164.1.335 Q9BXR0 TGT_HUMAN 93.035 0.992574 1.00248 QTRT1 - Queuine tRNA-ribosyltransferase catalytic subunit 1 - Homo sapiens (Human) - QTRT1 gene Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:11255023, PubMed:20354154). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity). Taurus_UMD|evm.model.AC_000164.1.336 A6H7I5 DYN2_BOVIN 100.000 0.365517 0.167436 DNM2 - Dynamin-2 - Bos taurus (Bovine) - DNM2 gene Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane. Taurus_UMD|evm.model.AC_000164.1.337 A6H7I5 DYN2_BOVIN 99.877 0.965517 0.971132 DNM2 - Dynamin-2 - Bos taurus (Bovine) - DNM2 gene Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane. Taurus_UMD|evm.model.AC_000164.1.338 Q2TBK5 TMED1_BOVIN 100.000 0.991228 1.00441 TMED1 - Transmembrane emp24 domain-containing protein 1 precursor - Bos taurus (Bovine) - TMED1 gene Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Taurus_UMD|evm.model.AC_000164.1.339 Q86X55 CARM1_HUMAN 98.502 0.731139 1.19901 CARM1 - Histone-arginine methyltransferase CARM1 - Homo sapiens (Human) - CARM1 gene Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs. Taurus_UMD|evm.model.AC_000164.1.340 Q9BWQ6 YIPF2_HUMAN 85.350 0.990385 0.987342 YIPF2 - Protein YIPF2 - Homo sapiens (Human) - YIPF2 gene Golgi apparatus, Golgi medial cisterna, Golgi trans cisterna, trans-Golgi network, transport vesicle Taurus_UMD|evm.model.AC_000164.1.341 Q9BSF4 TIM29_HUMAN 85.769 0.941818 1.05769 TIMM29 - Mitochondrial import inner membrane translocase subunit Tim29 precursor - Homo sapiens (Human) - TIMM29 gene Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40. Taurus_UMD|evm.model.AC_000164.1.342 P08642 RASH_CHICK 52.500 0.666667 0.904762 HRAS - GTPase HRas precursor - Gallus gallus (Chicken) - HRAS gene Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Taurus_UMD|evm.model.AC_000164.1.343 Q86UD7 TBC26_HUMAN 40.659 0.286624 1.256 TBC1D26 - TBC1 domain family member 26 - Homo sapiens (Human) - TBC1D26 gene May act as a GTPase-activating protein for Rab family protein(s). Taurus_UMD|evm.model.AC_000164.1.344 O43313 ATMIN_HUMAN 64.474 0.691589 0.130012 ATMIN - ATM interactor - Homo sapiens (Human) - ATMIN gene Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. Taurus_UMD|evm.model.AC_000164.1.345 P51532 SMCA4_HUMAN 95.227 0.998753 0.973892 SMARCA4 - Transcription activator BRG1 - Homo sapiens (Human) - SMARCA4 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities (By similarity). Taurus_UMD|evm.model.AC_000164.1.346 P01131 LDLR_BOVIN 100.000 0.997636 1.00118 LDLR - Low-density lipoprotein receptor precursor - Bos taurus (Bovine) - LDLR gene Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Taurus_UMD|evm.model.AC_000164.1.347 Q24JY3 SPC24_BOVIN 96.517 0.990099 1.02538 SPC24 - Kinetochore protein Spc24 - Bos taurus (Bovine) - SPC24 gene Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Taurus_UMD|evm.model.AC_000164.1.348 Q1LZH7 KANK2_BOVIN 98.261 0.901186 0.884615 KANK2 - KN motif and ankyrin repeat domain-containing protein 2 - Bos taurus (Bovine) - KANK2 gene Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (By similarity). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000164.1.349 Q96HP0 DOCK6_HUMAN 96.716 0.289938 1.02443 DOCK6 - Dedicator of cytokinesis protein 6 - Homo sapiens (Human) - DOCK6 gene Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). Taurus_UMD|evm.model.AC_000164.1.350 Q9UKR8 TSN16_HUMAN 72.414 0.942857 1 TSPAN16 - Tetraspanin-16 - Homo sapiens (Human) - TSPAN16 gene integral component of membrane, integral component of plasma membrane Taurus_UMD|evm.model.AC_000164.1.351 O95716 RAB3D_HUMAN 94.977 0.990909 1.00457 RAB3D - Ras-related protein Rab-3D - Homo sapiens (Human) - RAB3D gene Protein transport. Probably involved in regulated exocytosis (By similarity). Taurus_UMD|evm.model.AC_000164.1.352 Q32L10 TM205_BOVIN 100.000 0.989474 1.00529 TMEM205 - Transmembrane protein 205 - Bos taurus (Bovine) - TMEM205 gene Taurus_UMD|evm.model.AC_000164.1.353 P0C7I6 CC159_HUMAN 78.276 0.639381 1.52189 CCDC159 - Coiled-coil domain-containing protein 159 - Homo sapiens (Human) - CCDC159 gene Taurus_UMD|evm.model.AC_000164.1.354 Q29RT8 PLPR2_BOVIN 98.916 0.812362 1.16452 PLPPR2 - Phospholipid phosphatase-related protein type 2 - Bos taurus (Bovine) - PLPPR2 gene integral component of plasma membrane, lipid phosphatase activity, phosphatidate phosphatase activity, phospholipid dephosphorylation, phospholipid metabolic process, signal transduction Taurus_UMD|evm.model.AC_000164.1.355 Q6NVH7 SWAP1_HUMAN 81.057 0.900398 1.09607 SWSAP1 - ATPase SWSAP1 - Homo sapiens (Human) - SWSAP1 gene ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity. Taurus_UMD|evm.model.AC_000164.1.356 Q9MYZ9 EPOR_PIG 86.444 0.996071 1 EPOR - Erythropoietin receptor precursor - Sus scrofa (Pig) - EPOR gene Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase (By similarity). Taurus_UMD|evm.model.AC_000164.1.357 Q3MIN7 RGL3_HUMAN 80.845 0.972527 1.02535 RGL3 - Ral guanine nucleotide dissociation stimulator-like 3 - Homo sapiens (Human) - RGL3 gene Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity). Taurus_UMD|evm.model.AC_000164.1.358 A7MBH5 ODAD3_BOVIN 100.000 0.996785 1.00161 ODAD3 - Outer dynein arm-docking complex subunit 3 - Bos taurus (Bovine) - ODAD3 gene Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules. Taurus_UMD|evm.model.AC_000164.1.359 Q28034 GLU2B_BOVIN 100.000 0.852564 1.17073 PRKCSH - Glucosidase 2 subunit beta precursor - Bos taurus (Bovine) - PRKCSH gene Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (By similarity). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). Taurus_UMD|evm.model.AC_000164.1.360 Q14576 ELAV3_HUMAN 99.455 0.994565 1.00272 ELAVL3 - ELAV-like protein 3 - Homo sapiens (Human) - ELAVL3 gene RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437). May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance (By similarity). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity). Taurus_UMD|evm.model.AC_000164.1.361 Q96CK0 ZN653_HUMAN 93.707 0.948304 1.0065 ZNF653 - Zinc finger protein 653 - Homo sapiens (Human) - ZNF653 gene Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity. Taurus_UMD|evm.model.AC_000164.1.362 Q3SX05 ECSIT_BOVIN 100.000 0.995392 1.00231 ECSIT - Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor - Bos taurus (Bovine) - ECSIT gene Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). Taurus_UMD|evm.model.AC_000164.1.363 Q2HJ38 CNN1_BOVIN 100.000 0.993289 1.00337 CNN1 - Calponin-1 - Bos taurus (Bovine) - CNN1 gene Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). Taurus_UMD|evm.model.AC_000164.1.364 P60003 ELOF1_MOUSE 100.000 0.488095 2.0241 Elof1 - Transcription elongation factor 1 homolog - Mus musculus (Mouse) - Elof1 gene Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Taurus_UMD|evm.model.AC_000164.1.365 P09889 PPA5_PIG 88.496 0.971098 1.01765 ACP5 - Tartrate-resistant acid phosphatase type 5 precursor - Sus scrofa (Pig) - ACP5 gene Uteroferrin is a phosphoprotein phosphatase, synthesized in response to progesterone. It appears to function in transplacental transport of iron in pig. Taurus_UMD|evm.model.AC_000164.1.366 Q2HJ60 ROA2_BOVIN 79.167 0.512064 1.09384 HNRNPA2B1 - Heterogeneous nuclear ribonucleoproteins A2/B1 - Bos taurus (Bovine) - HNRNPA2B1 gene Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (By similarity). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (By similarity). Taurus_UMD|evm.model.AC_000164.1.367 E9Q6I0 V2116_MOUSE 54.545 0.882883 0.259346 Vmn2r116 - Vomeronasal type-2 receptor 116 precursor - Mus musculus (Mouse) - Vmn2r116 gene Receptor for the Esp1 pheromone. Mediates the response to Esp1 which enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation. Taurus_UMD|evm.model.AC_000164.1.368 Q96NG5 ZN558_HUMAN 86.070 0.995037 1.00249 ZNF558 - Zinc finger protein 558 - Homo sapiens (Human) - ZNF558 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.369 E9Q6I0 V2116_MOUSE 55.263 0.946078 0.238318 Vmn2r116 - Vomeronasal type-2 receptor 116 precursor - Mus musculus (Mouse) - Vmn2r116 gene Receptor for the Esp1 pheromone. Mediates the response to Esp1 which enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation. Taurus_UMD|evm.model.AC_000164.1.370 Q6AYK1 RNPS1_RAT 70.476 0.390977 0.872131 Rnps1 - RNA-binding protein with serine-rich domain 1 - Rattus norvegicus (Rat) - Rnps1 gene Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity). Taurus_UMD|evm.model.AC_000164.1.371 A6NE82 MB3L3_HUMAN 50.000 0.942408 0.918269 MBD3L3 - Putative methyl-CpG-binding domain protein 3-like 3 - Homo sapiens (Human) - MBD3L3 gene Taurus_UMD|evm.model.AC_000164.1.372 P06213 INSR_HUMAN 96.237 0.998554 1.00072 INSR - Insulin receptor precursor - Homo sapiens (Human) - INSR gene Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). Taurus_UMD|evm.model.AC_000164.1.373 Q6ZSZ5 ARHGI_HUMAN 76.979 0.955224 1.0338 ARHGEF18 - Rho guanine nucleotide exchange factor 18 - Homo sapiens (Human) - ARHGEF18 gene Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Taurus_UMD|evm.model.AC_000164.1.374 Q96HA9 PX11C_HUMAN 82.427 0.987552 1 PEX11G - Peroxisomal membrane protein 11C - Homo sapiens (Human) - PEX11G gene Promotes membrane protrusion and elongation on the peroxisomal surface. Taurus_UMD|evm.model.AC_000164.1.375 Q8NA69 TEX45_HUMAN 66.928 0.974855 1.02376 TEX45 - Testis-expressed protein 45 - Homo sapiens (Human) - TEX45 gene Taurus_UMD|evm.model.AC_000164.1.376 Q9NW07 ZN358_HUMAN 82.812 0.936348 1.05106 ZNF358 - Zinc finger protein 358 - Homo sapiens (Human) - ZNF358 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.377 Q9GZU1 MCLN1_HUMAN 93.276 0.996558 1.00172 MCOLN1 - Mucolipin-1 - Homo sapiens (Human) - MCOLN1 gene Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed:11013137, PubMed:12459486, PubMed:15336987, PubMed:14749347, PubMed:29019983, PubMed:27623384). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed:16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:27787197, PubMed:25733853). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (PubMed:27357649). Functions as a Fe(2+) permeable channel in late endosomes and lysosomes (PubMed:18794901). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (PubMed:25130899) In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). Taurus_UMD|evm.model.AC_000164.1.378 Q8IY17 PLPL6_HUMAN 93.500 0.990847 0.953455 PNPLA6 - Patatin-like phospholipase domain-containing protein 6 - Homo sapiens (Human) - PNPLA6 gene Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids (PubMed:11927584). Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides (PubMed:11927584). Taurus_UMD|evm.model.AC_000164.1.379 Q9P1Y5 CAMP3_HUMAN 88.688 0.99842 1.01361 CAMSAP3 - Calmodulin-regulated spectrin-associated protein 3 - Homo sapiens (Human) - CAMSAP3 gene Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:27802168, PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). Taurus_UMD|evm.model.AC_000164.1.380 Q9HCS7 SYF1_HUMAN 97.079 0.997666 1.00234 XAB2 - Pre-mRNA-splicing factor SYF1 - Homo sapiens (Human) - XAB2 gene Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing (PubMed:10944529, PubMed:17981804). Taurus_UMD|evm.model.AC_000164.1.381 E1BHC3 PT100_BOVIN 100.000 0.974026 1.01316 PET100 - Protein PET100 homolog, mitochondrial precursor - Bos taurus (Bovine) - PET100 gene Plays a role in mitochondrial complex IV assembly. Taurus_UMD|evm.model.AC_000164.1.382 P12660 PCP2_MOUSE 81.600 0.885714 1.16667 Pcp2 - Purkinje cell protein 2 - Mus musculus (Mouse) - Pcp2 gene May function as a cell-type specific modulator for G protein-mediated cell signaling. Taurus_UMD|evm.model.AC_000164.1.383 Q15833 STXB2_HUMAN 95.110 0.996633 1.00169 STXBP2 - Syntaxin-binding protein 2 - Homo sapiens (Human) - STXBP2 gene Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells. Taurus_UMD|evm.model.AC_000164.1.384 Q762I5 RETN_BOVIN 100.000 0.981818 1.00917 RETN - Resistin precursor - Bos taurus (Bovine) - RETN gene Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes (By similarity). Taurus_UMD|evm.model.AC_000164.1.385 Q8IX19 MCEM1_HUMAN 44.898 0.922705 1.10695 MCEMP1 - Mast cell-expressed membrane protein 1 - Homo sapiens (Human) - MCEMP1 gene plasma membrane, specific granule membrane, tertiary granule membrane, identical protein binding, neutrophil degranulation Taurus_UMD|evm.model.AC_000164.1.386 Q8IUR0 TPPC5_HUMAN 99.468 0.73913 1.34574 TRAPPC5 - Trafficking protein particle complex subunit 5 - Homo sapiens (Human) - TRAPPC5 gene May play a role in vesicular transport from endoplasmic reticulum to Golgi. Taurus_UMD|evm.model.AC_000164.1.387 P06734 FCER2_HUMAN 65.972 0.367609 1.21184 FCER2 - Low affinity immunoglobulin epsilon Fc receptor - Homo sapiens (Human) - FCER2 gene Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). Taurus_UMD|evm.model.AC_000164.1.388 P20821 GCSH_BOVIN 89.394 0.177596 2.11561 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Taurus_UMD|evm.model.AC_000164.1.389 Q8HY06 CLC4M_GORGO 48.344 0.565385 0.691489 CLEC4M - C-type lectin domain family 4 member M - Gorilla gorilla gorilla (Western lowland gorilla) - CLEC4M gene Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). Taurus_UMD|evm.model.AC_000164.1.390 Q96CN4 EVI5L_HUMAN 98.241 0.997491 1.00378 EVI5L - EVI5-like protein - Homo sapiens (Human) - EVI5L gene Functions as a GTPase-activating protein (GAP) with a broad specificity. Taurus_UMD|evm.model.AC_000164.1.391 Q9H6K5 PRR36_HUMAN 83.025 0.294602 0.812036 PRR36 - Proline-rich protein 36 - Homo sapiens (Human) - PRR36 gene Taurus_UMD|evm.model.AC_000164.1.392 Q6NSJ5 LRC8E_HUMAN 92.588 0.997491 1.00126 LRRC8E - Volume-regulated anion channel subunit LRRC8E - Homo sapiens (Human) - LRRC8E gene Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (PubMed:33139539). Taurus_UMD|evm.model.AC_000164.1.393 O14733 MP2K7_HUMAN 99.469 0.532578 1.68496 MAP2K7 - Dual specificity mitogen-activated protein kinase kinase 7 - Homo sapiens (Human) - MAP2K7 gene Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). Taurus_UMD|evm.model.AC_000164.1.394 Q13487 SNPC2_HUMAN 68.502 0.953216 1.02395 SNAPC2 - snRNA-activating protein complex subunit 2 - Homo sapiens (Human) - SNAPC2 gene Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. Taurus_UMD|evm.model.AC_000164.1.395 P60606 CTXN1_HUMAN 96.341 0.975904 1.0122 CTXN1 - Cortexin-1 - Homo sapiens (Human) - CTXN1 gene May mediate extracellular or intracellular signaling of cortical neurons during forebrain development. Taurus_UMD|evm.model.AC_000164.1.396 O43615 TIM44_HUMAN 90.989 0.995604 1.00664 TIMM44 - Mitochondrial import inner membrane translocase subunit TIM44 precursor - Homo sapiens (Human) - TIMM44 gene Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). Taurus_UMD|evm.model.AC_000164.1.397 Q15717 ELAV1_HUMAN 99.387 0.684211 1.45706 ELAVL1 - ELAV-like protein 1 - Homo sapiens (Human) - ELAVL1 gene RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:14731398). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). Taurus_UMD|evm.model.AC_000164.1.398 Q4PR21 CCL25_PIG 70.199 0.736318 1.33113 CCL25 - C-C motif chemokine 25 precursor - Sus scrofa (Pig) - CCL25 gene Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity). Taurus_UMD|evm.model.AC_000164.1.399 Q75N90 FBN3_HUMAN 83.667 0.992321 1.01994 FBN3 - Fibrillin-3 precursor - Homo sapiens (Human) - FBN3 gene Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-containing microfibrils provide long-term force bearing structural support. Taurus_UMD|evm.model.AC_000164.1.400 Q5E9R6 CERS4_BOVIN 100.000 0.994924 1.00254 CERS4 - Ceramide synthase 4 - Bos taurus (Bovine) - CERS4 gene Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor. Taurus_UMD|evm.model.AC_000164.1.401 A6QNY1 CD320_BOVIN 100.000 0.992188 1.00392 CD320 - CD320 antigen precursor - Bos taurus (Bovine) - CD320 gene Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Taurus_UMD|evm.model.AC_000164.1.402 Q05752 NDUA7_BOVIN 100.000 0.982456 1.00885 NDUFA7 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 - Bos taurus (Bovine) - NDUFA7 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000164.1.403 P62859 RS28_RAT 100.000 0.971429 1.01449 Rps28 - 40S ribosomal protein S28 - Rattus norvegicus (Rat) - Rps28 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, maturation of SSU-rRNA, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosome biogenesis Taurus_UMD|evm.model.AC_000164.1.404 Q6NY19 KANK3_HUMAN 78.947 0.966625 0.963095 KANK3 - KN motif and ankyrin repeat domain-containing protein 3 - Homo sapiens (Human) - KANK3 gene May be involved in the control of cytoskeleton formation by regulating actin polymerization. Taurus_UMD|evm.model.AC_000164.1.405 Q2KJ51 ANGL4_BOVIN 100.000 0.995134 1.00244 ANGPTL4 - Angiopoietin-related protein 4 precursor - Bos taurus (Bovine) - ANGPTL4 gene Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (By similarity). Depending on context, may modulate tumor-related angiogenesis (By similarity). Taurus_UMD|evm.model.AC_000164.1.406 O35509 RB11B_RAT 100.000 0.990868 1.00459 Rab11b - Ras-related protein Rab-11B precursor - Rattus norvegicus (Rat) - Rab11b gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. Taurus_UMD|evm.model.AC_000164.1.407 Q32L65 MARH2_BOVIN 100.000 0.779553 1.27755 MARCHF2 - E3 ubiquitin-protein ligase MARCHF2 - Bos taurus (Bovine) - MARCHF2 gene E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6. Taurus_UMD|evm.model.AC_000164.1.408 P52272 HNRPM_HUMAN 99.315 0.997264 1.00137 HNRNPM - Heterogeneous nuclear ribonucleoprotein M - Homo sapiens (Human) - HNRNPM gene Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. Taurus_UMD|evm.model.AC_000164.1.409 Q96QH2 PRAM_HUMAN 57.339 0.997072 1.0194 PRAM1 - PML-RARA-regulated adapter molecule 1 - Homo sapiens (Human) - PRAM1 gene May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P. Taurus_UMD|evm.model.AC_000164.1.410 Q32KV8 ZN414_BOVIN 99.233 0.994898 1.00256 ZNF414 - Zinc finger protein 414 - Bos taurus (Bovine) - ZNF414 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.411 O00160 MYO1F_HUMAN 95.173 0.99818 1.00091 MYO1F - Unconventional myosin-If - Homo sapiens (Human) - MYO1F gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Taurus_UMD|evm.model.AC_000164.1.412 Q9H324 ATS10_HUMAN 95.826 0.964943 1.03445 ADAMTS10 - A disintegrin and metalloproteinase with thrombospondin motifs 10 precursor - Homo sapiens (Human) - ADAMTS10 gene Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues. Taurus_UMD|evm.model.AC_000164.1.413 A0A5F9ZHS7 NFILZ_HUMAN 70.588 0.992032 0.868512 NFILZ - NFIL3 like protein - Homo sapiens (Human) - NFILZ gene Taurus_UMD|evm.model.AC_000164.1.414 Q2T9W4 ACTL9_BOVIN 100.000 0.995204 1.0024 ACTL9 - Actin-like protein 9 - Bos taurus (Bovine) - ACTL9 gene dynactin complex Taurus_UMD|evm.model.AC_000164.1.415 Q2HJ60 ROA2_BOVIN 77.731 0.65651 1.05865 HNRNPA2B1 - Heterogeneous nuclear ribonucleoproteins A2/B1 - Bos taurus (Bovine) - HNRNPA2B1 gene Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (By similarity). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (By similarity). Taurus_UMD|evm.model.AC_000164.1.416 Q86SQ3 AGRE4_HUMAN 69.231 0.801653 0.52954 ADGRE4P - Putative adhesion G protein-coupled receptor E4P precursor - Homo sapiens (Human) - ADGRE4P gene May mediate the cellular interaction between myeloid cells and B-cells. Taurus_UMD|evm.model.AC_000164.1.417 Q15370 ELOB_HUMAN 85.938 0.348066 1.5339 ELOB - Elongin-B - Homo sapiens (Human) - ELOB gene SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). Taurus_UMD|evm.model.AC_000164.1.418 O46415 FRIL_BOVIN 92.632 0.230392 2.33143 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000164.1.419 Q6PG31 RNPS1_DANRE 62.500 0.178899 0.770318 rnps1 - RNA-binding protein with serine-rich domain 1 - Danio rerio (Zebrafish) - rnps1 gene Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Putative component of the spliceosome which enhances the formation of the ATP-dependent A complex of the spliceosome. May participate in mRNA 3'-end cleavage. Also mediates increase of mRNA abundance and translational efficiency (By similarity). Taurus_UMD|evm.model.AC_000164.1.420 Q2HJ60 ROA2_BOVIN 75.630 0.671388 1.03519 HNRNPA2B1 - Heterogeneous nuclear ribonucleoproteins A2/B1 - Bos taurus (Bovine) - HNRNPA2B1 gene Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (By similarity). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (By similarity). Taurus_UMD|evm.model.AC_000164.1.421 Q86SQ3 AGRE4_HUMAN 69.856 0.227778 1.96937 ADGRE4P - Putative adhesion G protein-coupled receptor E4P precursor - Homo sapiens (Human) - ADGRE4P gene May mediate the cellular interaction between myeloid cells and B-cells. Taurus_UMD|evm.model.AC_000164.1.422 Q86SQ3 AGRE4_HUMAN 81.308 0.48855 1.43326 ADGRE4P - Putative adhesion G protein-coupled receptor E4P precursor - Homo sapiens (Human) - ADGRE4P gene May mediate the cellular interaction between myeloid cells and B-cells. Taurus_UMD|evm.model.AC_000164.1.423 Q14246 AGRE1_HUMAN 67.678 0.555102 1.65914 ADGRE1 - Adhesion G protein-coupled receptor E1 precursor - Homo sapiens (Human) - ADGRE1 gene Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development. Taurus_UMD|evm.model.AC_000164.1.424 Q08DN7 VAV_BOVIN 99.608 0.832787 0.361374 VAV1 - Proto-oncogene vav - Bos taurus (Bovine) - VAV1 gene Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. Taurus_UMD|evm.model.AC_000164.1.425 P54100 VAV_RAT 98.592 0.5 0.166074 Vav1 - Proto-oncogene vav - Rattus norvegicus (Rat) - Vav1 gene Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. Taurus_UMD|evm.model.AC_000164.1.426 Q08DN7 VAV_BOVIN 100.000 0.841102 0.559242 VAV1 - Proto-oncogene vav - Bos taurus (Bovine) - VAV1 gene Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. Taurus_UMD|evm.model.AC_000164.1.427 Q5RCJ1 CIP4_PONAB 92.015 0.325466 1.33943 TRIP10 - Cdc42-interacting protein 4 - Pongo abelii (Sumatran orangutan) - TRIP10 gene Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Also acts as a link between CDC42 signaling and regulation of the actin cytoskeleton. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization in the vicinity of membrane tubules by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization and dynamin may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. May be required for the lysosomal retention of FASLG/FASL (By similarity). Taurus_UMD|evm.model.AC_000164.1.428 Q148L1 GP108_BOVIN 99.737 0.530899 1.29927 GPR108 - Protein GPR108 precursor - Bos taurus (Bovine) - GPR108 gene cis-Golgi network membrane, Golgi apparatus, membrane, negative regulation of toll-like receptor signaling pathway, regulation of immune response Taurus_UMD|evm.model.AC_000164.1.429 Q2UVX4 CO3_BOVIN 97.524 0.998819 1.01927 C3 - Complement C3 precursor - Bos taurus (Bovine) - C3 gene C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (By similarity). Taurus_UMD|evm.model.AC_000164.1.430 O43557 TNF14_HUMAN 69.835 0.991736 1.00833 TNFSF14 - Tumor necrosis factor ligand superfamily member 14 - Homo sapiens (Human) - TNFSF14 gene Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM (PubMed:9462508, PubMed:10754304). Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (PubMed:10754304). Taurus_UMD|evm.model.AC_000164.1.431 Q3ZDR4 CD70_PIG 72.917 0.935644 1.06316 CD70 - CD70 antigen - Sus scrofa (Pig) - CD70 gene Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. Taurus_UMD|evm.model.AC_000164.1.432 P41273 TNFL9_HUMAN 49.804 0.972332 0.996063 TNFSF9 - Tumor necrosis factor ligand superfamily member 9 - Homo sapiens (Human) - TNFSF9 gene Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Taurus_UMD|evm.model.AC_000164.1.433 Q61469 PLPP1_MOUSE 42.857 0.642473 1.31449 Plpp1 - Phospholipid phosphatase 1 - Mus musculus (Mouse) - Plpp1 gene Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:8702556, PubMed:10359651, PubMed:10818444, PubMed:10620492, PubMed:15461590, PubMed:19215222). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:17379599). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (PubMed:17379599). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (PubMed:15461590, PubMed:17057224). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (PubMed:17057224). Taurus_UMD|evm.model.AC_000164.1.434 Q9D6F9 TBB4A_MOUSE 100.000 0.995506 1.00225 Tubb4a - Tubulin beta-4A chain - Mus musculus (Mouse) - Tubb4a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Taurus_UMD|evm.model.AC_000164.1.435 Q8IV53 DEN1C_HUMAN 78.589 0.997497 0.997503 DENND1C - DENN domain-containing protein 1C - Homo sapiens (Human) - DENND1C gene Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Taurus_UMD|evm.model.AC_000164.1.436 A0A5F4BST2 CRUM3_CANLF 76.190 0.827869 0.99187 CRB3 - Protein crumbs homolog 3 precursor - Canis lupus familiaris (Dog) - CRB3 gene Involved in the establishment of cell polarity in mammalian epithelial cells (By similarity). Regulates the morphogenesis of tight junctions (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). Taurus_UMD|evm.model.AC_000164.1.437 Q0II44 S2541_BOVIN 100.000 0.222541 3.9914 SLC25A41 - Mitochondrial carrier protein SCaMC-3L - Bos taurus (Bovine) - SLC25A41 gene Calcium-independent ATP-Mg/Pi exchanger that catalyzes the electroneutral exchange of Mg-ATP or free ADP against an hydrogenphosphate and participates in the net transport of adenine nucleotides across the mitochondria inner membrane. Taurus_UMD|evm.model.AC_000164.1.438 Q920P5 KAD5_MOUSE 31.548 0.88587 0.327402 Ak5 - Adenylate kinase isoenzyme 5 - Mus musculus (Mouse) - Ak5 gene Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. Taurus_UMD|evm.model.AC_000164.1.439 Q5EA53 T2FA_BOVIN 100.000 0.996139 1.00193 GTF2F1 - General transcription factor IIF subunit 1 - Bos taurus (Bovine) - GTF2F1 gene TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation (By similarity). Taurus_UMD|evm.model.AC_000164.1.440 O60542 PSPN_HUMAN 77.344 0.792208 0.987179 PSPN - Persephin precursor - Homo sapiens (Human) - PSPN gene Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Taurus_UMD|evm.model.AC_000164.1.441 Q2M2S8 ALKB7_BOVIN 100.000 0.990991 1.00452 ALKBH7 - Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial precursor - Bos taurus (Bovine) - ALKBH7 gene May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity (By similarity). Involved in fatty acid metabolism (By similarity). Taurus_UMD|evm.model.AC_000164.1.442 Q2KHU4 CLPP_BOVIN 100.000 0.992674 1.00368 CLPP - ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor - Bos taurus (Bovine) - CLPP gene Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion. Taurus_UMD|evm.model.AC_000164.1.443 Q8TDN7 ACER1_HUMAN 77.273 0.992453 1.00379 ACER1 - Alkaline ceramidase 1 - Homo sapiens (Human) - ACER1 gene Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (PubMed:17713573, PubMed:20207939, PubMed:20628055). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:12783875). Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide (PubMed:17713573, PubMed:20207939). May also hydrolyze dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis (PubMed:17713573). Taurus_UMD|evm.model.AC_000164.1.444 Q03111 ENL_HUMAN 91.367 0.93086 1.06082 MLLT1 - Protein ENL - Homo sapiens (Human) - MLLT1 gene Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). Taurus_UMD|evm.model.AC_000164.1.446 Q5FVE4 ACBG2_HUMAN 71.982 0.986745 1.01952 ACSBG2 - Long-chain-fatty-acid--CoA ligase ACSBG2 - Homo sapiens (Human) - ACSBG2 gene Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed:16371355, PubMed:16762313). Has increased ability to activate oleic and linoleic acid (PubMed:16371355). May play a role in spermatogenesis (PubMed:15685348). Taurus_UMD|evm.model.AC_000164.1.447 A6QLW9 RFX2_BOVIN 100.000 0.912467 1.06648 RFX2 - DNA-binding protein RFX2 - Bos taurus (Bovine) - RFX2 gene Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene H1-6. Taurus_UMD|evm.model.AC_000164.1.448 Q4R4T9 RANB3_MACFA 93.103 0.04811 1.16633 RANBP3 - Ran-binding protein 3 - Macaca fascicularis (Crab-eating macaque) - RANBP3 gene Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export (By similarity). Taurus_UMD|evm.model.AC_000164.1.449 Q0VCC0 CAYP1_BOVIN 100.000 0.989474 1.00529 CAPS - Calcyphosin - Bos taurus (Bovine) - CAPS gene Calcium-binding protein. May play a role in cellular signaling events (Potential). Taurus_UMD|evm.model.AC_000164.1.450 A7YWC8 VMAC_BOVIN 100.000 0.988024 1.00602 VMAC - Vimentin-type intermediate filament-associated coiled-coil protein - Bos taurus (Bovine) - VMAC gene type III intermediate filament Taurus_UMD|evm.model.AC_000164.1.451 Q8HXG6 NDUAB_BOVIN 100.000 0.985915 1.00709 NDUFA11 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 - Bos taurus (Bovine) - NDUFA11 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000164.1.452 Q11126 FUT3_BOVIN 99.452 0.994536 1.00274 FUT3 - 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 - Bos taurus (Bovine) - FUT3 gene Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors and participates in the blood groups Lewis determination and expression of Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens. Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sialyl Lewis a expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration. Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin. Prefers type 1 chain over type 2 acceptors. Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred. Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Taurus_UMD|evm.model.AC_000164.1.453 Q99748 NRTN_HUMAN 93.909 0.989899 1.00508 NRTN - Neurturin precursor - Homo sapiens (Human) - NRTN gene Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Taurus_UMD|evm.model.AC_000164.1.454 Q96G46 DUS3L_HUMAN 85.474 0.996928 1.00154 DUS3L - tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like - Homo sapiens (Human) - DUS3L gene Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Taurus_UMD|evm.model.AC_000164.1.455 Q8IZ63 PRR22_HUMAN 67.426 0.99536 1.02133 PRR22 - Proline-rich protein 22 - Homo sapiens (Human) - PRR22 gene Taurus_UMD|evm.model.AC_000164.1.456 E1B9E5 CTSRD_BOVIN 100.000 0.977979 0.988476 CATSPERD - Cation channel sperm-associated protein subunit delta precursor - Bos taurus (Bovine) - CATSPERD gene Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane. Taurus_UMD|evm.model.AC_000164.1.457 Q59HJ6 LONM_BOVIN 99.896 0.997921 1.00104 LONP1 - Lon protease homolog, mitochondrial precursor - Bos taurus (Bovine) - LONP1 gene ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (By similarity). Endogenous substrates include oxidized aconitase. Taurus_UMD|evm.model.AC_000164.1.458 Q3T171 RL36_BOVIN 100.000 0.981132 1.00952 RPL36 - 60S ribosomal protein L36 - Bos taurus (Bovine) - RPL36 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000164.1.459 Q6Q7D1 DHI1L_BOVIN 100.000 0.993056 1.00348 HSD11B1L - Hydroxysteroid 11-beta-dehydrogenase 1-like protein precursor - Bos taurus (Bovine) - HSD11B1L gene Taurus_UMD|evm.model.AC_000164.1.460 A1XQR7 MIC13_PIG 88.136 0.983193 1.00847 MICOS13 - MICOS complex subunit MIC13 - Sus scrofa (Pig) - MICOS13 gene Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex. Taurus_UMD|evm.model.AC_000164.1.461 Q5R452 SAFB1_PONAB 83.316 0.93921 1.07987 SAFB - Scaffold attachment factor B1 - Pongo abelii (Sumatran orangutan) - SAFB gene Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (By similarity). Thereby acts as a negative regulator of cell proliferation (By similarity). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Taurus_UMD|evm.model.AC_000164.1.462 Q5R452 SAFB1_PONAB 82.368 0.946115 0.873085 SAFB - Scaffold attachment factor B1 - Pongo abelii (Sumatran orangutan) - SAFB gene Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (By similarity). Thereby acts as a negative regulator of cell proliferation (By similarity). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Taurus_UMD|evm.model.AC_000164.1.463 Q14151 SAFB2_HUMAN 84.509 0.88604 1.10493 SAFB2 - Scaffold attachment factor B2 - Homo sapiens (Human) - SAFB2 gene Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. Taurus_UMD|evm.model.AC_000164.1.464 A0A2R8Y7D0 TINCR_HUMAN 97.674 0.965909 0.733333 TINCR - Ubiquitin domain-containing protein TINCR - Homo sapiens (Human) - TINCR gene Taurus_UMD|evm.model.AC_000164.1.465 Q4R6Y5 ZNRF4_MACFA 67.920 0.857759 1.08159 ZNRF4 - E3 ubiquitin-protein ligase ZNRF4 precursor - Macaca fascicularis (Crab-eating macaque) - ZNRF4 gene E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum. Could have a role in spermatogenesis. Taurus_UMD|evm.model.AC_000164.1.466 Q13332 PTPRS_HUMAN 95.893 0.998962 0.98922 PTPRS - Receptor-type tyrosine-protein phosphatase S precursor - Homo sapiens (Human) - PTPRS gene Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120). Taurus_UMD|evm.model.AC_000164.1.467 O94953 KDM4B_HUMAN 84.303 0.998209 1.01916 KDM4B - Lysine-specific demethylase 4B - Homo sapiens (Human) - KDM4B gene Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Taurus_UMD|evm.model.AC_000164.1.469 A7E320 UHRF1_BOVIN 100.000 0.997459 1.00127 UHRF1 - E3 ubiquitin-protein ligase UHRF1 - Bos taurus (Bovine) - UHRF1 gene Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair (By similarity). Taurus_UMD|evm.model.AC_000164.1.470 Q32KX1 ARRD5_BOVIN 99.699 0.924581 1.07831 ARRDC5 - Arrestin domain-containing protein 5 - Bos taurus (Bovine) - ARRDC5 gene Taurus_UMD|evm.model.AC_000164.1.471 Q5BLZ2 PLIN3_PIG 89.749 0.995444 1 PLIN3 - Perilipin-3 - Sus scrofa (Pig) - PLIN3 gene Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network. Taurus_UMD|evm.model.AC_000164.1.472 Q4JF29 TCAM1_BOVIN 98.956 0.997392 1.01054 TICAM1 - TIR domain-containing adapter molecule 1 - Bos taurus (Bovine) - TICAM1 gene Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (By similarity). Taurus_UMD|evm.model.AC_000164.1.473 Q29RM5 FEM1A_BOVIN 100.000 0.996942 1.00153 FEM1A - Protein fem-1 homolog A - Bos taurus (Bovine) - FEM1A gene Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. May participate in antiinflammatory signaling via its interaction with PTGER4 (By similarity). Taurus_UMD|evm.model.AC_000164.1.475 Q86TI2 DPP9_HUMAN 92.451 0.96347 1.01506 DPP9 - Dipeptidyl peptidase 9 - Homo sapiens (Human) - DPP9 gene Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:30291141, PubMed:29382749). Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism (PubMed:27820798, PubMed:30291141, PubMed:29967349, PubMed:31525884, PubMed:32796818). Taurus_UMD|evm.model.AC_000164.1.476 P62248 MYDGF_BOVIN 100.000 0.988571 1.00575 MYDGF - Myeloid-derived growth factor precursor - Bos taurus (Bovine) - MYDGF gene Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway. Taurus_UMD|evm.model.AC_000164.1.477 A5PK29 TP8L1_BOVIN 100.000 0.989305 1.00538 TNFAIP8L1 - Tumor necrosis factor alpha-induced protein 8-like protein 1 - Bos taurus (Bovine) - TNFAIP8L1 gene Acts as a negative regulator of mTOR activity. Taurus_UMD|evm.model.AC_000164.1.479 Q9H3T3 SEM6B_HUMAN 94.580 0.949612 0.871622 SEMA6B - Semaphorin-6B precursor - Homo sapiens (Human) - SEMA6B gene Functions as a cell surface repellent for mossy fibers of developping neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. Taurus_UMD|evm.model.AC_000164.1.480 P02750 A2GL_HUMAN 69.741 0.974576 1.02017 LRG1 - Leucine-rich alpha-2-glycoprotein precursor - Homo sapiens (Human) - LRG1 gene extracellular exosome, extracellular region, extracellular space, ficolin-1-rich granule lumen, intracellular membrane-bounded organelle, membrane, specific granule lumen, tertiary granule lumen, neutrophil degranulation Taurus_UMD|evm.model.AC_000164.1.481 A6QLL0 PLIN5_BOVIN 100.000 0.995624 1.00219 PLIN5 - Perilipin-5 - Bos taurus (Bovine) - PLIN5 gene Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). Taurus_UMD|evm.model.AC_000164.1.482 Q96Q06 PLIN4_HUMAN 61.238 0.984992 0.93294 PLIN4 - Perilipin-4 - Homo sapiens (Human) - PLIN4 gene May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity). Taurus_UMD|evm.model.AC_000164.1.483 Q7Z4V5 HDGR2_HUMAN 85.481 0.994065 1.00447 HDGFL2 - Hepatoma-derived growth factor-related protein 2 - Homo sapiens (Human) - HDGFL2 gene Involved in cellular growth control, through the regulation of cyclin D1 expression. Taurus_UMD|evm.model.AC_000164.1.484 Q2KIJ6 UBXN6_BOVIN 99.773 0.995475 1.00227 UBXN6 - UBX domain-containing protein 6 - Bos taurus (Bovine) - UBXN6 gene May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Taurus_UMD|evm.model.AC_000164.1.485 A6QLA6 CAF1A_BOVIN 100.000 0.927746 1.07676 CHAF1A - Chromatin assembly factor 1 subunit A - Bos taurus (Bovine) - CHAF1A gene Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. Taurus_UMD|evm.model.AC_000164.1.486 Q2KJA1 SH3G1_BOVIN 100.000 0.99458 1.00272 SH3GL1 - Endophilin-A2 - Bos taurus (Bovine) - SH3GL1 gene Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Taurus_UMD|evm.model.AC_000164.1.487 Q3TV65 MPND_MOUSE 85.287 0.882114 1.01027 Mpnd - MPN domain-containing protein - Mus musculus (Mouse) - Mpnd gene Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (By similarity). Taurus_UMD|evm.model.AC_000164.1.488 Q9UGK3 STAP2_HUMAN 75.366 0.995098 1.01241 STAP2 - Signal-transducing adaptor protein 2 - Homo sapiens (Human) - STAP2 gene Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. Taurus_UMD|evm.model.AC_000164.1.489 Q05B84 FSD1_BOVIN 100.000 0.995976 1.00202 FSD1 - Fibronectin type III and SPRY domain-containing protein 1 - Bos taurus (Bovine) - FSD1 gene May be involved in microtubule organization and stabilization. Taurus_UMD|evm.model.AC_000164.1.490 Q96BF3 TMIG2_HUMAN 53.846 0.918089 1.03901 TMIGD2 - Transmembrane and immunoglobulin domain-containing protein 2 precursor - Homo sapiens (Human) - TMIGD2 gene Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. Taurus_UMD|evm.model.AC_000164.1.491 Q96IW2 SHD_HUMAN 89.736 0.994152 1.00588 SHD - SH2 domain-containing adapter protein D - Homo sapiens (Human) - SHD gene May function as an adapter protein. Taurus_UMD|evm.model.AC_000164.1.492 Q9BW85 YJU2_HUMAN 84.520 0.993769 0.993808 YJU2 - Splicing factor YJU2 - Homo sapiens (Human) - YJU2 gene Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA (PubMed:29301961). Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453). Taurus_UMD|evm.model.AC_000164.1.493 Q14213 IL27B_HUMAN 73.451 0.965665 1.01747 EBI3 - Interleukin-27 subunit beta precursor - Homo sapiens (Human) - EBI3 gene Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. Taurus_UMD|evm.model.AC_000164.1.494 Q8TF21 ANR24_HUMAN 80.103 0.998209 0.974695 ANKRD24 - Ankyrin repeat domain-containing protein 24 - Homo sapiens (Human) - ANKRD24 gene Taurus_UMD|evm.model.AC_000164.1.495 Q8N6T7 SIR6_HUMAN 88.579 0.994444 1.01408 SIRT6 - NAD-dependent protein deacetylase sirtuin-6 - Homo sapiens (Human) - SIRT6 gene NAD-dependent protein deacetylase involved in various processes including telomere maintenance and gene expression, and consequently has roles in genomic stability, cell senescence and apoptosis (PubMed:18337721, PubMed:19135889, PubMed:19625767, PubMed:21362626). Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate (PubMed:21362626). Has deacetylase activity towards histone H3K9Ac and H3K56Ac (PubMed:19625767, PubMed:21362626). Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle (PubMed:19625767). May also be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance (PubMed:18337721). Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes (PubMed:21362626). Deacetylation of nucleosomes interferes with RELA binding to target DNA (PubMed:19135889). Acts as a corepressor of the transcription factor Hif1a to control the expression of multiple glycolytic genes to regulate glucose homeostasis (By similarity). Required for normal IGF1 serum levels and normal glucose homeostasis (By similarity). Regulates the production of TNF protein (By similarity). Has a role in the regulation of life span (By similarity). Taurus_UMD|evm.model.AC_000164.1.496 Q3SYZ3 CR3L3_BOVIN 100.000 0.995624 1.00219 CREB3L3 - Cyclic AMP-responsive element-binding protein 3-like protein 3 - Bos taurus (Bovine) - CREB3L3 gene Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression (By similarity). Regulates FGF21 transcription (By similarity). Taurus_UMD|evm.model.AC_000164.1.497 Q1HG70 MP2K2_CANLF 98.500 0.995012 1.0025 MAP2K2 - Dual specificity mitogen-activated protein kinase kinase 2 - Canis lupus familiaris (Dog) - MAP2K2 gene Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). Taurus_UMD|evm.model.AC_000164.1.498 O95365 ZBT7A_HUMAN 88.737 0.996409 0.953767 ZBTB7A - Zinc finger and BTB domain-containing protein 7A - Homo sapiens (Human) - ZBTB7A gene Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149). Taurus_UMD|evm.model.AC_000164.1.499 Q8N2W9 PIAS4_HUMAN 94.542 0.996109 1.00784 PIAS4 - E3 SUMO-protein ligase PIAS4 - Homo sapiens (Human) - PIAS4 gene Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Taurus_UMD|evm.model.AC_000164.1.500 P84246 H33_RABIT 98.529 0.985401 1.00735 H3-3A - Histone H3.3 - Oryctolagus cuniculus (Rabbit) - H3-3A gene Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000164.1.501 Q3SYU2 EF2_BOVIN 100.000 0.997672 1.00117 EEF2 - Elongation factor 2 - Bos taurus (Bovine) - EEF2 gene Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). Taurus_UMD|evm.model.AC_000164.1.502 O43293 DAPK3_HUMAN 94.934 0.995604 1.0022 DAPK3 - Death-associated protein kinase 3 - Homo sapiens (Human) - DAPK3 gene Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. Taurus_UMD|evm.model.AC_000164.1.503 Q9NPI5 NRK2_HUMAN 90.909 0.744318 0.765217 NMRK2 - Nicotinamide riboside kinase 2 - Homo sapiens (Human) - NMRK2 gene Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis. Taurus_UMD|evm.model.AC_000164.1.504 Q86WG3 ATCAY_HUMAN 94.609 0.994624 1.0027 ATCAY - Caytaxin - Homo sapiens (Human) - ATCAY gene Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites. Taurus_UMD|evm.model.AC_000164.1.505 Q9UPR6 ZFR2_HUMAN 63.409 0.909363 1.06922 ZFR2 - Zinc finger RNA-binding protein 2 - Homo sapiens (Human) - ZFR2 gene double-stranded RNA binding, single-stranded RNA binding Taurus_UMD|evm.model.AC_000164.1.506 P42679 MATK_HUMAN 80.381 0.994231 1.02564 MATK - Megakaryocyte-associated tyrosine-protein kinase - Homo sapiens (Human) - MATK gene Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. Taurus_UMD|evm.model.AC_000164.1.507 Q7YRX0 RAX2_BOVIN 100.000 0.989189 1.00543 RAX2 - Retina and anterior neural fold homeobox protein 2 - Bos taurus (Bovine) - RAX2 gene May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter (By similarity). Taurus_UMD|evm.model.AC_000164.1.508 Q3MHJ5 RM54_BOVIN 99.275 0.985612 1.00725 MRPL54 - 39S ribosomal protein L54, mitochondrial precursor - Bos taurus (Bovine) - MRPL54 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000164.1.509 O96018 APBA3_HUMAN 83.045 0.996546 1.00696 APBA3 - Amyloid-beta A4 precursor protein-binding family A member 3 - Homo sapiens (Human) - APBA3 gene May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN. Taurus_UMD|evm.model.AC_000164.1.510 O95049 ZO3_HUMAN 84.548 0.997812 0.994559 TJP3 - Tight junction protein ZO-3 - Homo sapiens (Human) - TJP3 gene TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). Taurus_UMD|evm.model.AC_000164.1.511 O60331 PI51C_HUMAN 94.188 0.997015 1.00299 PIP5K1C - Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma - Homo sapiens (Human) - PIP5K1C gene Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:12422219, PubMed:22942276). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (Probable). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport (By similarity). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis (PubMed:12847086). Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:12847086). Required for clathrin-coated pits assembly at the synapse (PubMed:17261850). Participates in cell junction assembly (PubMed:17261850). Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking (PubMed:17261850). Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions (PubMed:12422219). Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (PubMed:12422219). Required for uropodium formation and retraction of the cell rear during directed migration (By similarity). Has a role in growth factor-stimulated directional cell migration and adhesion (By similarity). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (PubMed:17635937). Negative regulator of T-cell activation and adhesion (By similarity). Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor (By similarity). Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (By similarity). Taurus_UMD|evm.model.AC_000164.1.512 Q8WUQ7 CATIN_HUMAN 90.415 0.910172 0.998681 CACTIN - Cactin - Homo sapiens (Human) - CACTIN gene Involved in the regulation of innate immune response (PubMed:20829348). Acts as negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (PubMed:20829348, PubMed:26363554). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (PubMed:20829348, PubMed:26363554). Taurus_UMD|evm.model.AC_000164.1.513 Q95125 TA2R_BOVIN 100.000 0.994186 1.00292 TBXA2R - Thromboxane A2 receptor - Bos taurus (Bovine) - TBXA2R gene Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase. Taurus_UMD|evm.model.AC_000164.1.514 Q8TF64 GIPC3_HUMAN 92.982 0.982609 0.36859 GIPC3 - PDZ domain-containing protein GIPC3 - Homo sapiens (Human) - GIPC3 gene Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion. Taurus_UMD|evm.model.AC_000164.1.515 Q32L68 HM20B_BOVIN 100.000 0.987013 0.485804 HMG20B - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related - Bos taurus (Bovine) - HMG20B gene Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters (By similarity). Taurus_UMD|evm.model.AC_000164.1.516 Q8R5M0 GIPC3_MOUSE 95.455 0.802752 0.734007 Gipc3 - PDZ domain-containing protein GIPC3 - Mus musculus (Mouse) - Gipc3 gene Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion. Taurus_UMD|evm.model.AC_000164.1.517 Q32L68 HM20B_BOVIN 100.000 0.672414 0.731861 HMG20B - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related - Bos taurus (Bovine) - HMG20B gene Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters (By similarity). Taurus_UMD|evm.model.AC_000164.1.518 A0A3Q2HW92 MFS12_HORSE 90.260 0.966457 0.997908 MFSD12 - Major facilitator superfamily domain-containing protein 12 - Equus caballus (Horse) - MFSD12 gene Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin/hair pigmentation. In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin/hair pigmentation. Also catalyzes import of cysteine into lysosomes in non-pigmented cells. Taurus_UMD|evm.model.AC_000164.1.519 Q2M2T2 CS071_BOVIN 99.333 0.506803 1.41346 Uncharacterized protein C19orf71 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000164.1.520 Q9R1K5 FZR1_MOUSE 98.986 0.995951 1.00203 Fzr1 - Fizzy-related protein homolog - Mus musculus (Mouse) - Fzr1 gene Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). Taurus_UMD|evm.model.AC_000164.1.521 Q0VC53 DOHH_BOVIN 100.000 0.993421 1.0033 DOHH - Deoxyhypusine hydroxylase - Bos taurus (Bovine) - DOHH gene Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. Taurus_UMD|evm.model.AC_000164.1.523 Q0VG18 SIM24_MOUSE 77.778 0.377778 1.125 Smim24 - Small integral membrane protein 24 precursor - Mus musculus (Mouse) - Smim24 gene Taurus_UMD|evm.model.AC_000164.1.524 Q0VG18 SIM24_MOUSE 44.643 0.339744 1.3 Smim24 - Small integral membrane protein 24 precursor - Mus musculus (Mouse) - Smim24 gene Taurus_UMD|evm.model.AC_000164.1.525 P21999 NFIC_PIG 99.407 0.996055 1.00198 NFIC - Nuclear factor 1 C-type - Sus scrofa (Pig) - NFIC gene Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Taurus_UMD|evm.model.AC_000164.1.526 Q8N6W0 CELF5_HUMAN 97.783 0.387189 2.1567 CELF5 - CUGBP Elav-like family member 5 - Homo sapiens (Human) - CELF5 gene RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Taurus_UMD|evm.model.AC_000164.1.527 O95977 S1PR4_HUMAN 85.714 0.994819 1.00521 S1PR4 - Sphingosine 1-phosphate receptor 4 - Homo sapiens (Human) - S1PR4 gene Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. Taurus_UMD|evm.model.AC_000164.1.528 P30679 GNA15_HUMAN 92.513 0.994667 1.00267 GNA15 - Guanine nucleotide-binding protein subunit alpha-15 - Homo sapiens (Human) - GNA15 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Taurus_UMD|evm.model.AC_000164.1.529 P38409 GNA11_BOVIN 100.000 0.994444 1.00279 GNA11 - Guanine nucleotide-binding protein subunit alpha-11 - Bos taurus (Bovine) - GNA11 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). Taurus_UMD|evm.model.AC_000164.1.530 Q08117 TLE5_HUMAN 100.000 0.74502 1.27411 TLE5 - TLE family member 5 - Homo sapiens (Human) - TLE5 gene Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. Taurus_UMD|evm.model.AC_000164.1.531 Q04725 TLE2_HUMAN 95.597 0.988748 0.956931 TLE2 - Transducin-like enhancer protein 2 - Homo sapiens (Human) - TLE2 gene Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). Taurus_UMD|evm.model.AC_000164.1.532 Q9H808 TLE6_HUMAN 55.732 0.982639 1.00699 TLE6 - Transducin-like enhancer protein 6 - Homo sapiens (Human) - TLE6 gene Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (By similarity). Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (By similarity). Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (By similarity). Taurus_UMD|evm.model.AC_000164.1.533 Q15935 ZNF77_HUMAN 54.709 0.993603 0.86055 ZNF77 - Zinc finger protein 77 - Homo sapiens (Human) - ZNF77 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.534 Q15935 ZNF77_HUMAN 57.500 0.849785 0.427523 ZNF77 - Zinc finger protein 77 - Homo sapiens (Human) - ZNF77 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.535 Q15935 ZNF77_HUMAN 52.535 0.990521 0.387156 ZNF77 - Zinc finger protein 77 - Homo sapiens (Human) - ZNF77 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.536 Q8NEP9 ZN555_HUMAN 86.476 0.988615 0.839172 ZNF555 - Zinc finger protein 555 - Homo sapiens (Human) - ZNF555 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.537 Q7L945 ZN627_HUMAN 88.372 0.3 0.303688 ZNF627 - Zinc finger protein 627 - Homo sapiens (Human) - ZNF627 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.538 Q86TJ5 ZN554_HUMAN 70.842 0.993852 0.907063 ZNF554 - Zinc finger protein 554 - Homo sapiens (Human) - ZNF554 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.539 Q1JPJ8 THOP1_BOVIN 99.854 0.997093 1.00146 THOP1 - Thimet oligopeptidase - Bos taurus (Bovine) - THOP1 gene Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (By similarity). Taurus_UMD|evm.model.AC_000164.1.540 Q32LM2 SGTA_BOVIN 100.000 0.829787 1.20128 SGTA - Small glutamine-rich tetratricopeptide repeat-containing protein alpha - Bos taurus (Bovine) - SGTA gene Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex. Binds directly to HSC70 and HSP70 and regulates their ATPase activity. Taurus_UMD|evm.model.AC_000164.1.541 Q5E960 S39A3_BOVIN 100.000 0.993651 1.00318 SLC39A3 - Zinc transporter ZIP3 - Bos taurus (Bovine) - SLC39A3 gene Acts as a zinc-influx transporter. Taurus_UMD|evm.model.AC_000164.1.542 O95057 DIRA1_HUMAN 97.980 0.98995 1.00505 DIRAS1 - GTP-binding protein Di-Ras1 precursor - Homo sapiens (Human) - DIRAS1 gene Displays low GTPase activity and exists predominantly in the GTP-bound form. Taurus_UMD|evm.model.AC_000164.1.544 P30671 GBG7_BOVIN 100.000 0.971014 1.01471 GNG7 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 precursor - Bos taurus (Bovine) - GNG7 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity). Taurus_UMD|evm.model.AC_000164.1.545 Q5E9A5 GA45B_BOVIN 99.333 0.247098 3.76875 GADD45B - Growth arrest and DNA damage-inducible protein GADD45 beta - Bos taurus (Bovine) - GADD45B gene Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity). Taurus_UMD|evm.model.AC_000164.1.546 Q03252 LMNB2_HUMAN 86.943 0.99682 1.01452 LMNB2 - Lamin-B2 precursor - Homo sapiens (Human) - LMNB2 gene Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Taurus_UMD|evm.model.AC_000164.1.547 Q9Y5L4 TIM13_HUMAN 98.947 0.979167 1.01053 TIMM13 - Mitochondrial import inner membrane translocase subunit Tim13 - Homo sapiens (Human) - TIMM13 gene Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Taurus_UMD|evm.model.AC_000164.1.548 Q7Z410 TMPS9_HUMAN 80.274 0.998175 1.03494 TMPRSS9 - Transmembrane protease serine 9 - Homo sapiens (Human) - TMPRSS9 gene Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed. Taurus_UMD|evm.model.AC_000164.1.549 Q8TCT7 SPP2B_HUMAN 83.513 0.953767 0.986486 SPPL2B - Signal peptide peptidase-like 2B precursor - Homo sapiens (Human) - SPPL2B gene Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). Taurus_UMD|evm.model.AC_000164.1.550 Q9UK45 LSM7_HUMAN 100.000 0.980769 1.00971 LSM7 - U6 snRNA-associated Sm-like protein LSm7 - Homo sapiens (Human) - LSM7 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). Taurus_UMD|evm.model.AC_000164.1.553 P0C6S8 LIGO3_HUMAN 93.412 0.996627 1.00169 LINGO3 - Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 precursor - Homo sapiens (Human) - LINGO3 gene extracellular matrix, extracellular space Taurus_UMD|evm.model.AC_000164.1.554 Q6ZS72 PEAK3_HUMAN 68.487 0.995717 0.987315 PEAK3 - Protein PEAK3 - Homo sapiens (Human) - PEAK3 gene Probable catalytically inactive kinase (Probable). Interacts with CRK-II and antagonizes CRK-II-signaling. Prevents the formation of CRK-II-dependent membrane ruffling and lamellipodia-like extensions (PubMed:31311869). Taurus_UMD|evm.model.AC_000164.1.555 Q56K12 OAZ1_BOVIN 87.500 0.991561 1.04405 OAZ1 - Ornithine decarboxylase antizyme 1 - Bos taurus (Bovine) - OAZ1 gene Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Taurus_UMD|evm.model.AC_000164.1.556 Q8TEK3 DOT1L_HUMAN 84.023 0.998687 0.990891 DOT1L - Histone-lysine N-methyltransferase, H3 lysine-79 specific - Homo sapiens (Human) - DOT1L gene Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). Taurus_UMD|evm.model.AC_000164.1.557 Q3ZCI3 PKHJ1_BOVIN 100.000 0.986667 1.00671 PLEKHJ1 - Pleckstrin homology domain-containing family J member 1 - Bos taurus (Bovine) - PLEKHJ1 gene early endosome, recycling endosome, trans-Golgi network, endosome organization, receptor recycling, retrograde transport, endosome to Golgi Taurus_UMD|evm.model.AC_000164.1.558 A5PJN8 SF3A2_BOVIN 100.000 0.910714 0.469602 SF3A2 - Splicing factor 3A subunit 2 - Bos taurus (Bovine) - SF3A2 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron. Taurus_UMD|evm.model.AC_000164.1.559 P03972 MIS_BOVIN 99.652 0.996528 1.00174 AMH - Muellerian-inhibiting factor precursor - Bos taurus (Bovine) - AMH gene This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. Taurus_UMD|evm.model.AC_000164.1.560 Q2YDF7 JSPR1_BOVIN 99.703 0.994083 1.00297 JSRP1 - Junctional sarcoplasmic reticulum protein 1 - Bos taurus (Bovine) - JSRP1 gene Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S (By similarity). EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. Taurus_UMD|evm.model.AC_000164.1.561 Q865S1 AP3D1_BOVIN 100.000 0.998344 1.00083 AP3D1 - AP-3 complex subunit delta-1 - Bos taurus (Bovine) - AP3D1 gene Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Taurus_UMD|evm.model.AC_000164.1.562 Q4R6V5 IZUM4_MACFA 84.018 0.990654 0.977169 IZUMO4 - Izumo sperm-egg fusion protein 4 precursor - Macaca fascicularis (Crab-eating macaque) - IZUMO4 gene Taurus_UMD|evm.model.AC_000164.1.563 Q58D63 MOB3A_BOVIN 100.000 0.990826 1.00461 MOB3A - MOB kinase activator 3A - Bos taurus (Bovine) - MOB3A gene May regulate the activity of kinases. Taurus_UMD|evm.model.AC_000164.1.564 Q9HBH9 MKNK2_HUMAN 94.409 0.995699 1 MKNK2 - MAP kinase-interacting serine/threonine-protein kinase 2 - Homo sapiens (Human) - MKNK2 gene Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. Taurus_UMD|evm.model.AC_000164.1.565 Q5RDM6 RAP1B_PONAB 98.370 0.989189 1.00543 RAP1B - Ras-related protein Rap-1b precursor - Pongo abelii (Sumatran orangutan) - RAP1B gene GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity). Taurus_UMD|evm.model.AC_000164.1.566 Q0VCP4 SEPT8_BOVIN 99.536 0.88843 1.09502 SEPTIN8 - Septin-8 - Bos taurus (Bovine) - SEPTIN8 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (By similarity). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). Taurus_UMD|evm.model.AC_000164.1.567 Q6ZMN8 CCNI2_HUMAN 53.333 0.776744 0.582656 CCNI2 - Cyclin-I2 - Homo sapiens (Human) - CCNI2 gene cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus, cyclin-dependent protein serine/threonine kinase regulator activity, mitotic cell cycle phase transition, regulation of cyclin-dependent protein serine/threonine kinase activity Taurus_UMD|evm.model.AC_000164.1.568 Q9Y496 KIF3A_HUMAN 98.999 0.997143 1.00143 KIF3A - Kinesin-like protein KIF3A - Homo sapiens (Human) - KIF3A gene Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. Taurus_UMD|evm.model.AC_000164.1.569 P30367 IL4_BOVIN 100.000 0.985294 1.00741 IL4 - Interleukin-4 precursor - Bos taurus (Bovine) - IL4 gene Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. Taurus_UMD|evm.model.AC_000164.1.570 Q9XSV9 IL13_BOVIN 100.000 0.984962 1.00758 IL13 - Interleukin-13 precursor - Bos taurus (Bovine) - IL13 gene Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. Taurus_UMD|evm.model.AC_000164.1.571 Q92878 RAD50_HUMAN 95.046 0.998477 1.00076 RAD50 - DNA repair protein RAD50 - Homo sapiens (Human) - RAD50 gene Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). Taurus_UMD|evm.model.AC_000164.1.572 Q3SZP0 IRF1_BOVIN 99.689 0.993808 1.00311 IRF1 - Interferon regulatory factor 1 - Bos taurus (Bovine) - IRF1 gene Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (By similarity). Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (By similarity). Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Binds to a consensus sequence in gene promoters (By similarity). Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (By similarity). Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (By similarity). Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells (By similarity). Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development (By similarity). Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells (By similarity). Taurus_UMD|evm.model.AC_000164.1.574 O76082 S22A5_HUMAN 88.869 0.813988 1.20646 SLC22A5 - Solute carrier family 22 member 5 - Homo sapiens (Human) - SLC22A5 gene Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. Taurus_UMD|evm.model.AC_000164.1.575 Q9H015 S22A4_HUMAN 86.618 0.99639 1.00544 SLC22A4 - Solute carrier family 22 member 4 - Homo sapiens (Human) - SLC22A4 gene Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). Taurus_UMD|evm.model.AC_000164.1.576 Q3T005 PDLI4_BOVIN 100.000 0.993976 1.00302 PDLIM4 - PDZ and LIM domain protein 4 - Bos taurus (Bovine) - PDLIM4 gene Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). Taurus_UMD|evm.model.AC_000164.1.578 O15460 P4HA2_HUMAN 90.811 0.996403 1.03925 P4HA2 - Prolyl 4-hydroxylase subunit alpha-2 precursor - Homo sapiens (Human) - P4HA2 gene Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Taurus_UMD|evm.model.AC_000164.1.579 P79103 RS4_BOVIN 98.479 0.992424 1.0038 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000164.1.581 P11052 CSF2_BOVIN 100.000 0.986111 1.00699 CSF2 - Granulocyte-macrophage colony-stimulating factor precursor - Bos taurus (Bovine) - CSF2 gene Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Taurus_UMD|evm.model.AC_000164.1.582 P49875 IL3_BOVIN 100.000 0.986207 1.00694 IL3 - Interleukin-3 precursor - Bos taurus (Bovine) - IL3 gene Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Taurus_UMD|evm.model.AC_000164.1.583 Q9UKU0 ACSL6_HUMAN 92.683 0.962656 1.0373 ACSL6 - Long-chain-fatty-acid--CoA ligase 6 - Homo sapiens (Human) - ACSL6 gene Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. Taurus_UMD|evm.model.AC_000164.1.584 Q8TF40 FNIP1_HUMAN 93.843 0.791201 1.22813 FNIP1 - Folliculin-interacting protein 1 - Homo sapiens (Human) - FNIP1 gene Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (By similarity). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases (PubMed:24081491). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Required for B-cell development (By similarity). Taurus_UMD|evm.model.AC_000164.1.585 Q8TEU7 RPGF6_HUMAN 93.408 0.998751 1 RAPGEF6 - Rap guanine nucleotide exchange factor 6 - Homo sapiens (Human) - RAPGEF6 gene Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. Taurus_UMD|evm.model.AC_000164.1.586 A6QLJ4 C42S2_BOVIN 100.000 0.976471 1.0119 CDC42SE2 - CDC42 small effector protein 2 - Bos taurus (Bovine) - CDC42SE2 gene Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity). Taurus_UMD|evm.model.AC_000164.1.587 Q2M2S9 LYRM7_BOVIN 99.038 0.980952 1.00962 LYRM7 - Complex III assembly factor LYRM7 - Bos taurus (Bovine) - LYRM7 gene Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity). Taurus_UMD|evm.model.AC_000164.1.588 P62958 HINT1_BOVIN 100.000 0.984252 1.00794 HINT1 - Histidine triad nucleotide-binding protein 1 - Bos taurus (Bovine) - HINT1 gene Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Taurus_UMD|evm.model.AC_000164.1.589 Q70JA7 CHSS3_HUMAN 95.000 0.996161 0.590703 CHSY3 - Chondroitin sulfate synthase 3 - Homo sapiens (Human) - CHSY3 gene Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. Taurus_UMD|evm.model.AC_000164.1.590 Q70JA7 CHSS3_HUMAN 93.956 0.997238 0.410431 CHSY3 - Chondroitin sulfate synthase 3 - Homo sapiens (Human) - CHSY3 gene Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. Taurus_UMD|evm.model.AC_000164.1.591 P59773 MNARL_HUMAN 84.127 0.806867 1.22632 MINAR2 - Major intrinsically disordered NOTCH2-binding receptor 1-like - Homo sapiens (Human) - MINAR2 gene Taurus_UMD|evm.model.AC_000164.1.592 Q8TE59 ATS19_HUMAN 79.948 0.381687 0.805302 ADAMTS19 - A disintegrin and metalloproteinase with thrombospondin motifs 19 precursor - Homo sapiens (Human) - ADAMTS19 gene extracellular matrix, metalloendopeptidase activity, extracellular matrix organization Taurus_UMD|evm.model.AC_000164.1.593 A6QLY4 ISOC1_BOVIN 100.000 0.993311 1.00336 ISOC1 - Isochorismatase domain-containing protein 1 - Bos taurus (Bovine) - ISOC1 gene cytoplasm Taurus_UMD|evm.model.AC_000164.1.594 Q9Y2P4 S27A6_HUMAN 80.861 0.477958 0.696284 SLC27A6 - Long-chain fatty acid transport protein 6 - Homo sapiens (Human) - SLC27A6 gene Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart (PubMed:12556534). Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs) (By similarity). Taurus_UMD|evm.model.AC_000164.1.595 P35556 FBN2_HUMAN 95.437 0.958717 0.931662 FBN2 - Fibrillin-2 precursor - Homo sapiens (Human) - FBN2 gene Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Taurus_UMD|evm.model.AC_000164.1.596 P55011 S12A2_HUMAN 94.889 0.99834 0.994224 SLC12A2 - Solute carrier family 12 member 2 - Homo sapiens (Human) - SLC12A2 gene Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume. Taurus_UMD|evm.model.AC_000164.1.597 Q96M27 PRRC1_HUMAN 96.797 0.59322 1.06067 PRRC1 - Protein PRRC1 - Homo sapiens (Human) - PRRC1 gene cytoplasm, protein kinase A regulatory subunit binding, activation of protein kinase A activity Taurus_UMD|evm.model.AC_000164.1.598 Q96KG7 MEG10_HUMAN 95.652 0.988566 0.997368 MEGF10 - Multiple epidermal growth factor-like domains protein 10 precursor - Homo sapiens (Human) - MEGF10 gene Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells (PubMed:27170117). Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides (PubMed:20828568, PubMed:17643423). Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum (PubMed:27170117). Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:28498977, Ref.14). May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (PubMed:17498693, PubMed:17643423, PubMed:20828568, PubMed:22101682, PubMed:27170117, PubMed:28498977). Taurus_UMD|evm.model.AC_000164.1.599 A6NC05 YD286_HUMAN 85.965 0.482759 0.84058 C5orf63 - Glutaredoxin-like protein C5orf63 - Homo sapiens (Human) - C5orf63 gene Taurus_UMD|evm.model.AC_000164.1.600 P20290 BTF3_HUMAN 82.581 0.894737 0.830097 BTF3 - Transcription factor BTF3 - Homo sapiens (Human) - BTF3 gene When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. Taurus_UMD|evm.model.AC_000164.1.601 Q13796 SHRM2_HUMAN 71.186 0.297436 0.120668 SHROOM2 - Protein Shroom2 - Homo sapiens (Human) - SHROOM2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). Taurus_UMD|evm.model.AC_000164.1.602 A0JN69 MARH3_BOVIN 100.000 0.992126 1.00395 MARCHF3 - E3 ubiquitin-protein ligase MARCHF3 - Bos taurus (Bovine) - MARCHF3 gene E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Taurus_UMD|evm.model.AC_000164.1.603 P20700 LMNB1_HUMAN 90.420 0.924883 1.09044 LMNB1 - Lamin-B1 precursor - Homo sapiens (Human) - LMNB1 gene Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Taurus_UMD|evm.model.AC_000164.1.604 A8SMG2 TEX43_BOVIN 100.000 0.985075 1.00752 TEX43 - Testis-expressed protein 43 - Bos taurus (Bovine) - TEX43 gene Taurus_UMD|evm.model.AC_000164.1.605 Q3MHI4 PHAX_BOVIN 100.000 0.994937 1.00254 PHAX - Phosphorylated adapter RNA export protein - Bos taurus (Bovine) - PHAX gene A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA (By similarity). Taurus_UMD|evm.model.AC_000164.1.606 Q2KJC9 AL7A1_BOVIN 100.000 0.411168 0.365492 ALDH7A1 - Alpha-aminoadipic semialdehyde dehydrogenase precursor - Bos taurus (Bovine) - ALDH7A1 gene Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity). Taurus_UMD|evm.model.AC_000164.1.607 Q2KJC9 AL7A1_BOVIN 99.814 0.996296 1.00186 ALDH7A1 - Alpha-aminoadipic semialdehyde dehydrogenase precursor - Bos taurus (Bovine) - ALDH7A1 gene Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity). Taurus_UMD|evm.model.AC_000164.1.608 Q5R8N8 GRM2B_PONAB 87.621 0.931973 0.988789 GRAMD2B - GRAM domain-containing protein 2B - Pongo abelii (Sumatran orangutan) - GRAMD2B gene cytoplasmic microtubule Taurus_UMD|evm.model.AC_000164.1.609 Q9XSU7 RL27_CANLF 62.195 0.962963 0.595588 RPL27 - 60S ribosomal protein L27 - Canis lupus familiaris (Dog) - RPL27 gene Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity). Taurus_UMD|evm.model.AC_000164.1.610 Q3SZY3 PTTG1_BOVIN 90.594 0.990148 1.00495 PTTG1 - Securin - Bos taurus (Bovine) - PTTG1 gene Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity). Taurus_UMD|evm.model.AC_000164.1.613 P51176 TGM2_BOVIN 100.000 0.592593 0.117904 TGM2 - Protein-glutamine gamma-glutamyltransferase 2 - Bos taurus (Bovine) - TGM2 gene Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (By similarity). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:9880554). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:9880554). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (By similarity). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (By similarity). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (By similarity). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:25128524). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (By similarity). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (By similarity). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (By similarity). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (By similarity). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (By similarity). May also act as an isopeptidase cleaving the previously formed cross-links (By similarity). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (By similarity). Taurus_UMD|evm.model.AC_000164.1.614 Q9ULD9 ZN608_HUMAN 94.518 0.998676 0.999339 ZNF608 - Zinc finger protein 608 - Homo sapiens (Human) - ZNF608 gene Transcription factor, which represses ZNF609 transcription. Taurus_UMD|evm.model.AC_000164.1.617 Q92900 RENT1_HUMAN 46.377 0.624339 0.167405 UPF1 - Regulator of nonsense transcripts 1 - Homo sapiens (Human) - UPF1 gene RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability. Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA hardoring long 3'UTR by inducing the NMD machinery (By similarity). Taurus_UMD|evm.model.AC_000164.1.618 Q5R893 H2B1_PONAB 96.032 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000164.1.619 Q5R4V3 KC1G3_PONAB 98.684 0.995614 1 CSNK1G3 - Casein kinase I isoform gamma-3 - Pongo abelii (Sumatran orangutan) - CSNK1G3 gene Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Taurus_UMD|evm.model.AC_000164.1.620 A0JN62 CE120_BOVIN 100.000 0.997976 1.00101 CEP120 - Centrosomal protein of 120 kDa - Bos taurus (Bovine) - CEP120 gene Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000164.1.621 A6QPM3 PRDM6_BOVIN 100.000 0.996616 1.00169 PRDM6 - Putative histone-lysine N-methyltransferase PRDM6 - Bos taurus (Bovine) - PRDM6 gene Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. Taurus_UMD|evm.model.AC_000164.1.622 Q08E11 PPIC_BOVIN 100.000 0.99061 1.00472 PPIC - Peptidyl-prolyl cis-trans isomerase C - Bos taurus (Bovine) - PPIC gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Taurus_UMD|evm.model.AC_000164.1.623 Q17QS1 SNX24_BOVIN 100.000 0.988235 1.00592 SNX24 - Sorting nexin-24 - Bos taurus (Bovine) - SNX24 gene May be involved in several stages of intracellular trafficking. Taurus_UMD|evm.model.AC_000164.1.624 Q2TBW7 SNX2_BOVIN 99.615 0.996154 1.00193 SNX2 - Sorting nexin-2 - Bos taurus (Bovine) - SNX2 gene Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (By similarity). Taurus_UMD|evm.model.AC_000164.1.625 Q9Y6H5 SNCAP_HUMAN 89.239 0.945361 1.0555 SNCAIP - Synphilin-1 - Homo sapiens (Human) - SNCAIP gene Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. Taurus_UMD|evm.model.AC_000164.1.627 A6QQM4 ZN474_BOVIN 99.185 0.867612 0.931718 ZNF474 - Zinc finger protein 474 - Bos taurus (Bovine) - ZNF474 gene Taurus_UMD|evm.model.AC_000164.1.628 P33072 LYOX_BOVIN 99.522 0.995227 1.00239 LOX - Protein-lysine 6-oxidase precursor - Bos taurus (Bovine) - LOX gene Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). Taurus_UMD|evm.model.AC_000164.1.629 Q05B65 SRFB1_BOVIN 94.393 0.995074 0.948598 SRFBP1 - Serum response factor-binding protein 1 - Bos taurus (Bovine) - SRFBP1 gene May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). Taurus_UMD|evm.model.AC_000164.1.630 Q2YDI9 FTMT_BOVIN 99.587 0.99177 1.00413 FTMT - Ferritin, mitochondrial precursor - Bos taurus (Bovine) - FTMT gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Taurus_UMD|evm.model.AC_000164.1.631 P05387 RLA2_HUMAN 93.846 0.48855 1.13913 RPLP2 - 60S acidic ribosomal protein P2 - Homo sapiens (Human) - RPLP2 gene Plays an important role in the elongation step of protein synthesis. Taurus_UMD|evm.model.AC_000164.1.632 Q8TBA6 GOGA5_HUMAN 74.457 0.989071 0.250342 GOLGA5 - Golgin subfamily A member 5 - Homo sapiens (Human) - GOLGA5 gene Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. Taurus_UMD|evm.model.AC_000164.1.633 Q66LM5 F170A_MACFA 45.198 0.508671 1.22261 FAM170A - Protein FAM170A - Macaca fascicularis (Crab-eating macaque) - FAM170A gene Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE) (By similarity). Taurus_UMD|evm.model.AC_000164.1.634 Q08E26 CRTC2_BOVIN 63.731 0.652174 0.730159 CRTC2 - CREB-regulated transcription coactivator 2 - Bos taurus (Bovine) - CRTC2 gene Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). Taurus_UMD|evm.model.AC_000164.1.635 P62912 RL32_RAT 74.074 0.97561 0.607407 Rpl32 - 60S ribosomal protein L32 - Rattus norvegicus (Rat) - Rpl32 gene cytosolic large ribosomal subunit, polysomal ribosome, cellular response to dexamethasone stimulus, cytoplasmic translation, liver regeneration Taurus_UMD|evm.model.AC_000164.1.636 Q569H4 LARGN_HUMAN 90.171 0.991489 0.773026 PRR16 - Protein Largen - Homo sapiens (Human) - PRR16 gene Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration. Taurus_UMD|evm.model.AC_000164.1.637 P68105 EF1A1_RABIT 97.186 0.99568 1.00216 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000164.1.638 Q9H329 E41LB_HUMAN 91.083 0.742857 0.233333 EPB41L4B - Band 4.1-like protein 4B - Homo sapiens (Human) - EPB41L4B gene Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927). Taurus_UMD|evm.model.AC_000164.1.639 Q569H4 LARGN_HUMAN 91.228 0.666667 0.276316 PRR16 - Protein Largen - Homo sapiens (Human) - PRR16 gene Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration. Taurus_UMD|evm.model.AC_000164.1.641 Q2HJF1 RM53_BOVIN 84.722 0.959459 0.660714 MRPL53 - 39S ribosomal protein L53, mitochondrial precursor - Bos taurus (Bovine) - MRPL53 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Taurus_UMD|evm.model.AC_000164.1.642 A1A519 F170A_HUMAN 72.892 0.993994 1.00909 FAM170A - Protein FAM170A - Homo sapiens (Human) - FAM170A gene Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE). Taurus_UMD|evm.model.AC_000164.1.643 P51659 DHB4_HUMAN 85.734 0.997286 1.00136 HSD17B4 - Peroxisomal multifunctional enzyme type 2 - Homo sapiens (Human) - HSD17B4 gene Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from straight-chain, 2-methyl-branched-chain fatty acids bile acid intermediates. With EHHADH, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity (PubMed:10671535). Taurus_UMD|evm.model.AC_000164.1.644 A4IF78 TFIP8_BOVIN 100.000 0.59697 1.66667 TNFAIP8 - Tumor necrosis factor alpha-induced protein 8 - Bos taurus (Bovine) - TNFAIP8 gene Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity). Taurus_UMD|evm.model.AC_000164.1.645 Q9Y485 DMXL1_HUMAN 92.287 0.999337 0.996696 DMXL1 - DmX-like protein 1 - Homo sapiens (Human) - DMXL1 gene RAVE complex, vacuolar acidification Taurus_UMD|evm.model.AC_000164.1.646 Q8NBA8 DTWD2_HUMAN 71.951 0.618557 0.651007 DTWD2 - tRNA-uridine aminocarboxypropyltransferase 2 - Homo sapiens (Human) - DTWD2 gene Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)) (PubMed:31804502). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)) (PubMed:31804502). Taurus_UMD|evm.model.AC_000164.1.647 Q2HJ75 RITA1_BOVIN 66.667 0.880952 0.312268 RITA1 - RBPJ-interacting and tubulin-associated protein 1 - Bos taurus (Bovine) - RITA1 gene Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity). Taurus_UMD|evm.model.AC_000164.1.650 Q10126 YSM6_CAEEL 30.000 0.484642 1.05018 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000164.1.651 Q9H2E6 SEM6A_HUMAN 91.085 0.99799 0.966019 SEMA6A - Semaphorin-6A precursor - Homo sapiens (Human) - SEMA6A gene Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. Taurus_UMD|evm.model.AC_000164.1.652 Q9Y6G5 COMDA_HUMAN 92.353 0.913514 0.915842 COMMD10 - COMM domain-containing protein 10 - Homo sapiens (Human) - COMMD10 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Taurus_UMD|evm.model.AC_000164.1.653 Q8N8L6 ARL10_HUMAN 91.393 0.991837 1.0041 ARL10 - ADP-ribosylation factor-like protein 10 - Homo sapiens (Human) - ARL10 gene Taurus_UMD|evm.model.AC_000164.1.654 Q5E996 NOP16_BOVIN 100.000 0.988827 1.00562 NOP16 - Nucleolar protein 16 - Bos taurus (Bovine) - NOP16 gene nucleolus, ribosomal large subunit biogenesis Taurus_UMD|evm.model.AC_000164.1.655 Q9CQJ1 HIG2A_MOUSE 83.810 0.971963 1.00943 Higd2a - HIG1 domain family member 2A - Mus musculus (Mouse) - Higd2a gene Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes (By similarity). Taurus_UMD|evm.model.AC_000164.1.656 P04975 CLCB_BOVIN 100.000 0.991266 1.00439 CLTB - Clathrin light chain B - Bos taurus (Bovine) - CLTB gene Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Taurus_UMD|evm.model.AC_000164.1.657 Q2HJD0 FAF2_BOVIN 100.000 0.995516 1.00225 FAF2 - FAS-associated factor 2 - Bos taurus (Bovine) - FAF2 gene Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. Taurus_UMD|evm.model.AC_000164.1.658 Q7L0R7 RNF44_HUMAN 93.287 0.995381 1.00231 RNF44 - RING finger protein 44 - Homo sapiens (Human) - RNF44 gene Taurus_UMD|evm.model.AC_000164.1.659 Q9BYE9 CDHR2_HUMAN 76.198 0.998474 1.00076 CDHR2 - Cadherin-related family member 2 precursor - Homo sapiens (Human) - CDHR2 gene Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409). May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771). Taurus_UMD|evm.model.AC_000164.1.660 Q7Z2K8 GRIN1_HUMAN 65.538 0.997833 0.915675 GPRIN1 - G protein-regulated inducer of neurite outgrowth 1 - Homo sapiens (Human) - GPRIN1 gene May be involved in neurite outgrowth. Taurus_UMD|evm.model.AC_000164.1.661 P33567 SYUB_BOVIN 98.507 0.985185 1.00746 SNCB - Beta-synuclein - Bos taurus (Bovine) - SNCB gene May be involved in neuronal plasticity. Taurus_UMD|evm.model.AC_000164.1.662 A6NMX2 I4E1B_HUMAN 88.360 0.810345 0.958678 EIF4E1B - Eukaryotic translation initiation factor 4E type 1B - Homo sapiens (Human) - EIF4E1B gene Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure. Taurus_UMD|evm.model.AC_000164.1.663 Q58DN3 TSN17_BOVIN 100.000 0.953901 1.04444 TSPAN17 - Tetraspanin-17 - Bos taurus (Bovine) - TSPAN17 gene Regulates ADAM10 maturation. Taurus_UMD|evm.model.AC_000164.1.664 Q8K1S4 UNC5A_MOUSE 96.009 0.997785 1.00557 Unc5a - Netrin receptor UNC5A precursor - Mus musculus (Mouse) - Unc5a gene Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Taurus_UMD|evm.model.AC_000164.1.665 P52790 HXK3_HUMAN 90.693 0.997838 1.00217 HK3 - Hexokinase-3 - Homo sapiens (Human) - HK3 gene Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:8717435). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:8717435). Taurus_UMD|evm.model.AC_000164.1.666 A0P8Z5 UIMC1_PIG 87.293 0.924552 1.0846 UIMC1 - BRCA1-A complex subunit RAP80 - Sus scrofa (Pig) - UIMC1 gene Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. Taurus_UMD|evm.model.AC_000164.1.667 Q32L68 HM20B_BOVIN 96.622 0.936306 0.990536 HMG20B - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related - Bos taurus (Bovine) - HMG20B gene Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters (By similarity). Taurus_UMD|evm.model.AC_000164.1.668 O43447 PPIH_HUMAN 82.486 0.987805 0.926554 PPIH - Peptidyl-prolyl cis-trans isomerase H - Homo sapiens (Human) - PPIH gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. Taurus_UMD|evm.model.AC_000164.1.669 Q5R4W8 ZN346_PONAB 92.258 0.993548 1 ZNF346 - Zinc finger protein 346 - Pongo abelii (Sumatran orangutan) - ZNF346 gene Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. Taurus_UMD|evm.model.AC_000164.1.670 P22455 FGFR4_HUMAN 92.893 0.980025 0.998753 FGFR4 - Fibroblast growth factor receptor 4 precursor - Homo sapiens (Human) - FGFR4 gene Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling. Taurus_UMD|evm.model.AC_000164.1.671 Q96L73 NSD1_HUMAN 90.519 0.996296 0.901335 NSD1 - Histone-lysine N-methyltransferase, H3 lysine-36 specific - Homo sapiens (Human) - NSD1 gene Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. Taurus_UMD|evm.model.AC_000164.1.672 Q969Q5 RAB24_HUMAN 98.522 0.990196 1.00493 RAB24 - Ras-related protein Rab-24 - Homo sapiens (Human) - RAB24 gene May be involved in autophagy-related processes. Taurus_UMD|evm.model.AC_000164.1.673 Q32KN9 PRLD1_BOVIN 100.000 0.990909 1.00457 PRELID1 - PRELI domain-containing protein 1, mitochondrial precursor - Bos taurus (Bovine) - PRELID1 gene Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs (By similarity). Taurus_UMD|evm.model.AC_000164.1.674 Q9BW11 MAD3_HUMAN 91.748 0.990338 1.00485 MXD3 - Max dimerization protein 3 - Homo sapiens (Human) - MXD3 gene Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity). Taurus_UMD|evm.model.AC_000164.1.676 Q12907 LMAN2_HUMAN 94.930 0.983333 1.01124 LMAN2 - Vesicular integral-membrane protein VIP36 precursor - Homo sapiens (Human) - LMAN2 gene Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity). Taurus_UMD|evm.model.AC_000164.1.677 O43566 RGS14_HUMAN 89.789 0.996466 1 RGS14 - Regulator of G-protein signaling 14 - Homo sapiens (Human) - RGS14 gene Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. Taurus_UMD|evm.model.AC_000164.1.678 O97704 NPT2A_SHEEP 97.027 0.996875 1.00156 SLC34A1 - Sodium-dependent phosphate transport protein 2A - Ovis aries (Sheep) - SLC34A1 gene Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx. Taurus_UMD|evm.model.AC_000164.1.679 Q32PB1 PROF3_BOVIN 100.000 0.985507 1.0073 PFN3 - Profilin-3 - Bos taurus (Bovine) - PFN3 gene Binds to actin and affects the structure of the cytoskeleton. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Slightly reduces actin polymerization. May be involved in spermatogenesis. Taurus_UMD|evm.model.AC_000164.1.680 P98140 FA12_BOVIN 98.039 0.996689 0.986928 F12 - Coagulation factor XII precursor - Bos taurus (Bovine) - F12 gene Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). Taurus_UMD|evm.model.AC_000164.1.681 P43250 GRK6_HUMAN 96.707 0.986301 1.01389 GRK6 - G protein-coupled receptor kinase 6 - Homo sapiens (Human) - GRK6 gene Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). Taurus_UMD|evm.model.AC_000164.1.683 P0C6T3 PRR7_RAT 96.654 0.992593 1.00372 Prr7 - Proline-rich protein 7 - Rattus norvegicus (Rat) - Prr7 gene Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (PubMed:27458189). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (By similarity). Might promote apoptosis in T cells (By similarity). Taurus_UMD|evm.model.AC_000164.1.684 Q16643 DREB_HUMAN 89.846 0.981846 1.01849 DBN1 - Drebrin - Homo sapiens (Human) - DBN1 gene Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). Taurus_UMD|evm.model.AC_000164.1.685 Q9NR12 PDLI7_HUMAN 94.323 0.889105 1.12473 PDLIM7 - PDZ and LIM domain protein 7 - Homo sapiens (Human) - PDLIM7 gene May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). Taurus_UMD|evm.model.AC_000164.1.686 Q7L591 DOK3_HUMAN 77.728 0.995475 0.891129 DOK3 - Docking protein 3 - Homo sapiens (Human) - DOK3 gene DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). Taurus_UMD|evm.model.AC_000164.1.687 Q9UJV9 DDX41_HUMAN 99.196 0.988854 1.00965 DDX41 - Probable ATP-dependent RNA helicase DDX41 - Homo sapiens (Human) - DDX41 gene Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000164.1.688 A7MB40 F193B_BOVIN 100.000 0.439159 1.09842 FAM193B - Protein FAM193B - Bos taurus (Bovine) - FAM193B gene cytoplasm, nucleus Taurus_UMD|evm.model.AC_000164.1.689 Q99KF1 TMED9_MOUSE 67.662 0.884956 0.961702 Tmed9 - Transmembrane emp24 domain-containing protein 9 precursor - Mus musculus (Mouse) - Tmed9 gene Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 (By similarity). Taurus_UMD|evm.model.AC_000164.1.690 P68105 EF1A1_RABIT 94.589 0.995662 0.997835 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000164.1.691 Q3T133 TMED9_BOVIN 100.000 0.991525 1.00426 TMED9 - Transmembrane emp24 domain-containing protein 9 precursor - Bos taurus (Bovine) - TMED9 gene Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 (By similarity). Taurus_UMD|evm.model.AC_000164.1.692 Q9UBV7 B4GT7_HUMAN 92.966 0.993902 1.00306 B4GALT7 - Beta-1,4-galactosyltransferase 7 - Homo sapiens (Human) - B4GALT7 gene Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts. Taurus_UMD|evm.model.AC_000164.1.693 O15049 N4BP3_HUMAN 91.758 0.996324 1 N4BP3 - NEDD4-binding protein 3 - Homo sapiens (Human) - N4BP3 gene Plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage. Taurus_UMD|evm.model.AC_000164.1.694 Q91YQ7 RMD5B_MOUSE 97.118 0.88491 0.994911 Rmnd5b - E3 ubiquitin-protein transferase RMND5B - Mus musculus (Mouse) - Rmnd5b gene Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. Taurus_UMD|evm.model.AC_000164.1.695 Q5E950 NHP2_BOVIN 100.000 0.987013 1.00654 NHP2 - H/ACA ribonucleoprotein complex subunit 2 - Bos taurus (Bovine) - NHP2 gene Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). Taurus_UMD|evm.model.AC_000164.1.696 Q99729 ROAA_HUMAN 93.994 0.993994 1.00301 HNRNPAB - Heterogeneous nuclear ribonucleoprotein A/B - Homo sapiens (Human) - HNRNPAB gene Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site. Taurus_UMD|evm.model.AC_000164.1.697 Q8IUZ5 AT2L2_HUMAN 91.686 0.523002 1.83556 PHYKPL - 5-phosphohydroxy-L-lysine phospho-lyase - Homo sapiens (Human) - PHYKPL gene Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde. Taurus_UMD|evm.model.AC_000164.1.698 Q86Y22 CONA1_HUMAN 81.690 0.393258 0.32963 COL23A1 - Collagen alpha-1(XXIII) chain - Homo sapiens (Human) - COL23A1 gene collagen-containing extracellular matrix, endoplasmic reticulum lumen, extracellular matrix, extracellular space, plasma membrane, extracellular matrix structural constituent, collagen fibril organization, extracellular matrix organization Taurus_UMD|evm.model.AC_000164.1.699 Q9HAZ1 CLK4_HUMAN 97.297 0.995851 1.00208 CLK4 - Dual specificity protein kinase CLK4 - Homo sapiens (Human) - CLK4 gene Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Taurus_UMD|evm.model.AC_000164.1.700 O60765 Z354A_HUMAN 89.934 0.823129 1.21488 ZNF354A - Zinc finger protein 354A - Homo sapiens (Human) - ZNF354A gene cytosol, nucleolus, nucleoplasm, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II, sensory perception of sound Taurus_UMD|evm.model.AC_000164.1.701 Q8MJI9 PROP1_BOVIN 99.558 0.991189 1.00442 PROP1 - Homeobox protein prophet of Pit-1 - Bos taurus (Bovine) - PROP1 gene Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes. Taurus_UMD|evm.model.AC_000164.1.702 P27115 MGAT1_RABIT 92.617 0.995536 1.00224 MGAT1 - Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase - Oryctolagus cuniculus (Rabbit) - MGAT1 gene Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. Taurus_UMD|evm.model.AC_000164.1.704 Q8NB50 ZFP62_HUMAN 93.080 0.997696 0.964444 ZFP62 - Zinc finger protein 62 homolog - Homo sapiens (Human) - ZFP62 gene May play a role in differentiating skeletal muscle. Taurus_UMD|evm.model.AC_000164.1.705 P62752 RL23A_RAT 92.958 0.686275 0.653846 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000164.1.706 Q6UXG8 BTNL9_HUMAN 68.720 0.690789 0.568224 BTNL9 - Butyrophilin-like protein 9 precursor - Homo sapiens (Human) - BTNL9 gene external side of plasma membrane, plasma membrane, signaling receptor binding, adaptive immune response, regulation of cytokine production, T cell receptor signaling pathway Taurus_UMD|evm.model.AC_000164.1.707 Q6UXG8 BTNL9_HUMAN 65.882 0.948276 0.433645 BTNL9 - Butyrophilin-like protein 9 precursor - Homo sapiens (Human) - BTNL9 gene external side of plasma membrane, plasma membrane, signaling receptor binding, adaptive immune response, regulation of cytokine production, T cell receptor signaling pathway Taurus_UMD|evm.model.AC_000164.1.708 Q9C029 TRIM7_HUMAN 89.824 0.996055 0.992172 TRIM7 - E3 ubiquitin-protein ligase TRIM7 - Homo sapiens (Human) - TRIM7 gene E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of proinflammatory cytokines and type I interferon (By similarity). Plays also a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128). Taurus_UMD|evm.model.AC_000164.1.709 Q8WV44 TRI41_HUMAN 96.508 0.996825 1 TRIM41 - E3 ubiquitin-protein ligase TRIM41 - Homo sapiens (Human) - TRIM41 gene Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C. Taurus_UMD|evm.model.AC_000164.1.710 P63245 RACK1_RAT 100.000 0.993711 1.00315 Rack1 - Receptor of activated protein C kinase 1 - Rattus norvegicus (Rat) - Rack1 gene Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:15340087). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane. Taurus_UMD|evm.model.AC_000164.1.711 Q8WV44 TRI41_HUMAN 77.885 0.279133 0.585714 TRIM41 - E3 ubiquitin-protein ligase TRIM41 - Homo sapiens (Human) - TRIM41 gene Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C. Taurus_UMD|evm.model.AC_000164.1.712 P13753 HA1B_BOVIN 45.324 0.701799 1.06868 BOLA class I histocompatibility antigen, alpha chain BL3-7 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000164.1.713 Q3T9E4 TGTP2_MOUSE 43.223 0.92619 1.01205 Tgtp2 - T-cell-specific guanine nucleotide triphosphate-binding protein 2 - Mus musculus (Mouse) - Tgtp2 gene Involved in innate cell-autonomous resistance to intracellular pathogens, such as Toxoplasma gondii. During avirulent type II T. gondii infection, recruited to the parasitophorous vacuole (PV) membrane, leading to PV vesiculation and rupture, and subsequent digestion of the parasite within the cytosol (PubMed:19265156, PubMed:24563254). Not recruited to virulent type I T. gondii PV membrane (PubMed:19265156). May confer an antiviral state for vesicular stomatitis virus (PubMed:9725230). Taurus_UMD|evm.model.AC_000164.1.714 Q86W50 MET16_HUMAN 76.712 0.755208 0.341637 METTL16 - RNA N6-adenosine-methyltransferase METTL16 - Homo sapiens (Human) - METTL16 gene RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197299, PubMed:30197297). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197299, PubMed:30197297). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing and/or stability of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression (PubMed:28525753). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). Taurus_UMD|evm.model.AC_000164.1.715 Q96IT1 ZN496_HUMAN 83.844 0.996599 1.0017 ZNF496 - Zinc finger protein 496 - Homo sapiens (Human) - ZNF496 gene DNA-binding transcription factor that can both act as an activator and a repressor. Taurus_UMD|evm.model.AC_000164.1.716 A6QLE5 NLRP3_BOVIN 89.428 0.997949 0.945684 NLRP3 - NACHT, LRR and PYD domains-containing protein 3 - Bos taurus (Bovine) - NLRP3 gene As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (By similarity). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, cytosolic dsRNA, etc. However, it is unclear what constitutes the direct NLRP3 activator. Activation in presence of cytosolic dsRNA is mediated by DHX33 (By similarity). Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth. During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). Taurus_UMD|evm.model.AC_000164.1.717 O95918 OR2H2_HUMAN 60.690 0.947368 0.487179 OR2H2 - Olfactory receptor 2H2 - Homo sapiens (Human) - OR2H2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000164.1.718 Q5JQS6 GSAML_HUMAN 56.643 0.692308 1.44444 GCSAML - Germinal center-associated signaling and motility-like protein - Homo sapiens (Human) - GCSAML gene Taurus_UMD|evm.model.AC_000164.1.719 Q8NGG2 OR5T2_HUMAN 47.525 0.980519 0.857939 OR5T2 - Olfactory receptor 5T2 - Homo sapiens (Human) - OR5T2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000164.1.721 Q5E9Y2 STX17_BOVIN 84.783 0.387931 0.384106 STX17 - Syntaxin-17 - Bos taurus (Bovine) - STX17 gene SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (By similarity). Taurus_UMD|evm.model.AC_000164.1.722 Q8NG77 O2T12_HUMAN 72.941 0.960227 0.55 OR2T12 - Olfactory receptor 2T12 - Homo sapiens (Human) - OR2T12 gene Odorant receptor. Taurus_UMD|evm.model.AC_000164.1.723 Q8NG06 TRI58_HUMAN 82.268 0.991803 1.00412 TRIM58 - E3 ubiquitin-protein ligase TRIM58 - Homo sapiens (Human) - TRIM58 gene E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization. Taurus_UMD|evm.model.AC_000164.1.724 Q8NG80 OR2L5_HUMAN 80.000 0.969466 0.839744 OR2L5 - Olfactory receptor 2L5 - Homo sapiens (Human) - OR2L5 gene Odorant receptor. Taurus_UMD|evm.model.AC_000164.1.725 Q8NGY9 OR2L8_HUMAN 82.143 0.989848 0.63141 OR2L8 - Olfactory receptor 2L8 - Homo sapiens (Human) - OR2L8 gene Odorant receptor. Taurus_UMD|evm.model.AC_000164.1.726 Q6EE22 UNK_CANLF 88.406 0.384181 0.218519 UNK - RING finger protein unkempt homolog - Canis lupus familiaris (Dog) - UNK gene Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes. Taurus_UMD|evm.model.AC_000164.1.727 P51989 RO21_XENLA 75.377 0.775591 0.734104 Heterogeneous nuclear ribonucleoprotein A2 homolog 1 - Xenopus laevis (African clawed frog) Taurus_UMD|evm.model.AC_000164.1.728 Q8NH03 OR2T3_HUMAN 78.667 0.949045 0.493711 OR2T3 - Olfactory receptor 2T3 - Homo sapiens (Human) - OR2T3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000164.1.730 A2VE33 LYPD8_BOVIN 100.000 0.974468 1.02174 LYPD8 - Ly6/PLAUR domain-containing protein 8 precursor - Bos taurus (Bovine) - LYPD8 gene Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis. Taurus_UMD|evm.model.AC_000164.1.732 Q0V8K7 3BP5L_BOVIN 100.000 0.920228 0.911688 SH3BP5L - SH3 domain-binding protein 5-like - Bos taurus (Bovine) - SH3BP5L gene Functions as guanine nucleotide exchange factor (GEF) for RAB11A. Taurus_UMD|evm.model.AC_000164.1.733 Q499Z4 ZN672_HUMAN 80.435 0.982833 1.03097 ZNF672 - Zinc finger protein 672 - Homo sapiens (Human) - ZNF672 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000164.1.734 A0JNJ4 ZN692_BOVIN 99.804 0.977011 1.02353 ZNF692 - Zinc finger protein 692 - Bos taurus (Bovine) - ZNF692 gene May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway. Taurus_UMD|evm.model.AC_000164.1.735 Q6P3X8 PGBD2_HUMAN 90.102 0.883686 1.11824 PGBD2 - PiggyBac transposable element-derived protein 2 - Homo sapiens (Human) - PGBD2 gene sequence-specific DNA binding Taurus_UMD|evm.model.AC_000164.1.736 O43869 OR2T1_HUMAN 52.469 0.894444 0.487805 OR2T1 - Olfactory receptor 2T1 - Homo sapiens (Human) - OR2T1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000164.1.737 O75899 GABR2_HUMAN 89.130 0.542169 0.088204 GABBR2 - Gamma-aminobutyric acid type B receptor subunit 2 precursor - Homo sapiens (Human) - GABBR2 gene Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:9872744, PubMed:10906333, PubMed:10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Taurus_UMD|evm.model.AC_000164.1.739 E9Q6I0 V2116_MOUSE 73.196 0.536313 0.209112 Vmn2r116 - Vomeronasal type-2 receptor 116 precursor - Mus musculus (Mouse) - Vmn2r116 gene Receptor for the Esp1 pheromone. Mediates the response to Esp1 which enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation. Taurus_UMD|evm.model.AC_000164.1.740 Q9Z2V6 HDAC5_MOUSE 62.500 0.177966 0.318059 Hdac5 - Histone deacetylase 5 - Mus musculus (Mouse) - Hdac5 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). Serves as a corepressor of RARA and causes its deacetylation (By similarity). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity). Taurus_UMD|evm.model.AC_000164.1.741 Q2HJ61 PLPP2_BOVIN 100.000 0.993056 1.00348 PLPP2 - Phospholipid phosphatase 2 - Bos taurus (Bovine) - PLPP2 gene Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (By similarity). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (By similarity). Taurus_UMD|evm.model.AC_000164.1.742 A5PJX4 MIER2_BOVIN 99.822 0.996441 1.00178 MIER2 - Mesoderm induction early response protein 2 - Bos taurus (Bovine) - MIER2 gene Transcriptional repressor. Taurus_UMD|evm.model.AC_000164.1.743 Q9JMB1 THEG_MOUSE 72.293 0.816754 1.01867 Theg - Testicular haploid expressed gene protein - Mus musculus (Mouse) - Theg gene May be involved (but not essential) in spermatogenesis. Taurus_UMD|evm.model.AC_000164.1.744 Q8TF44 C2C4C_HUMAN 89.835 0.995249 1 C2CD4C - C2 calcium-dependent domain-containing protein 4C - Homo sapiens (Human) - C2CD4C gene Taurus_UMD|evm.model.AC_000164.1.745 P98077 SHC2_HUMAN 87.037 0.84252 0.872852 SHC2 - SHC-transforming protein 2 - Homo sapiens (Human) - SHC2 gene Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity). Taurus_UMD|evm.model.AC_000164.1.746 Q3SX64 OD3L2_HUMAN 81.818 0.657074 1.44291 ODF3L2 - Outer dense fiber protein 3-like protein 2 - Homo sapiens (Human) - ODF3L2 gene cytoplasmic microtubule, cytoskeleton Taurus_UMD|evm.model.AC_000164.1.747 Q13477 MADCA_HUMAN 56.122 0.670588 1.11257 MADCAM1 - Mucosal addressin cell adhesion molecule 1 precursor - Homo sapiens (Human) - MADCAM1 gene Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding. Taurus_UMD|evm.model.AC_000164.1.748 Q6ZTW0 TPGS1_HUMAN 87.241 0.953795 1.04483 TPGS1 - Tubulin polyglutamylase complex subunit 1 - Homo sapiens (Human) - TPGS1 gene May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity). Taurus_UMD|evm.model.AC_000164.1.749 P49427 UB2R1_HUMAN 98.305 0.991489 0.995763 CDC34 - Ubiquitin-conjugating enzyme E2 R1 - Homo sapiens (Human) - CDC34 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:22496338). Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes (PubMed:10329681, PubMed:10373550, PubMed:10871850, PubMed:11675391, PubMed:12037680, PubMed:15652359, PubMed:17461777, PubMed:17698585, PubMed:19112177, PubMed:19126550, PubMed:19945379, PubMed:20061386, PubMed:20347421). Taurus_UMD|evm.model.AC_000164.1.750 P51124 GRAM_HUMAN 69.636 0.945946 1.00778 GZMM - Granzyme M precursor - Homo sapiens (Human) - GZMM gene Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. Taurus_UMD|evm.model.AC_000164.1.751 Q9UL51 HCN2_HUMAN 95.901 0.762085 1.18673 HCN2 - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 - Homo sapiens (Human) - HCN2 gene Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity). Taurus_UMD|evm.model.AC_000164.1.752 O00411 RPOM_HUMAN 68.116 0.998363 0.993496 POLRMT - DNA-directed RNA polymerase, mitochondrial precursor - Homo sapiens (Human) - POLRMT gene DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:21278163). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:29149603). Taurus_UMD|evm.model.AC_000164.1.753 Q9ESS2 FGF22_MOUSE 77.083 0.836257 1.05556 Fgf22 - Fibroblast growth factor 22 precursor - Mus musculus (Mouse) - Fgf22 gene Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development. Taurus_UMD|evm.model.AC_000164.1.754 Q0II22 RN126_BOVIN 100.000 0.993631 1.00319 RNF126 - E3 ubiquitin-protein ligase RNF126 - Bos taurus (Bovine) - RNF126 gene E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor. May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination. By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation. May monoubiquitinate AICDA. Taurus_UMD|evm.model.AC_000164.1.755 Q1LZB9 FSTL3_BOVIN 100.000 0.992366 1.00383 FSTL3 - Follistatin-related protein 3 precursor - Bos taurus (Bovine) - FSTL3 gene The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10 (By similarity). Taurus_UMD|evm.model.AC_000164.1.756 Q6UWY2 PRS57_HUMAN 77.899 0.957746 1.00353 PRSS57 - Serine protease 57 precursor - Homo sapiens (Human) - PRSS57 gene Serine protease that cleaves preferentially after Arg residues (PubMed:22474388, PubMed:23904161, PubMed:25156428). Can also cleave after citrulline (deimidated arginine) and methylarginine residues (PubMed:25156428). Taurus_UMD|evm.model.AC_000164.1.757 Q2MJV8 PALM_PIG 87.855 0.929952 1.06977 PALM - Paralemmin-1 precursor - Sus scrofa (Pig) - PALM gene Involved in plasma membrane dynamics and cell process formation. Necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000164.1.758 Q8IVT2 MISP_HUMAN 59.807 0.997101 1.0162 MISP - Mitotic interactor and substrate of PLK1 - Homo sapiens (Human) - MISP gene Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. Taurus_UMD|evm.model.AC_000164.1.759 P20160 CAP7_HUMAN 79.757 0.991903 0.984064 AZU1 - Azurocidin precursor - Homo sapiens (Human) - AZU1 gene This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G. Taurus_UMD|evm.model.AC_000164.1.760 Q61096 PRTN3_MOUSE 70.281 0.957198 1.01181 Prtn3 - Myeloblastin precursor - Mus musculus (Mouse) - Prtn3 gene Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177. Taurus_UMD|evm.model.AC_000164.1.761 Q3UP87 ELNE_MOUSE 77.328 0.914179 1.01132 Elane - Neutrophil elastase precursor - Mus musculus (Mouse) - Elane gene Medullasin modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (By similarity). Capable of killing E.coli; probably digests outer membrane protein A (ompA) in E.coli (PubMed:10947984). Taurus_UMD|evm.model.AC_000164.1.762 Q29099 PTBP1_PIG 97.666 0.996416 1.0018 PTBP1 - Polypyrimidine tract-binding protein 1 - Sus scrofa (Pig) - PTBP1 gene Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (By similarity). Taurus_UMD|evm.model.AC_000164.1.763 Q6T4P5 PLPR3_HUMAN 80.357 0.964523 0.628134 PLPPR3 - Phospholipid phosphatase-related protein type 3 - Homo sapiens (Human) - PLPPR3 gene integral component of plasma membrane, lipid phosphatase activity, phosphatidate phosphatase activity, phospholipid dephosphorylation, phospholipid metabolic process, signal transduction Taurus_UMD|evm.model.AC_000164.1.764 Q3T0A3 CFAD_BOVIN 100.000 0.992308 1.00386 CFD - Complement factor D precursor - Bos taurus (Bovine) - CFD gene Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (By similarity). Taurus_UMD|evm.model.AC_000164.1.765 Q3T0A3 CFAD_BOVIN 88.889 0.718593 0.76834 CFD - Complement factor D precursor - Bos taurus (Bovine) - CFD gene Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (By similarity). Taurus_UMD|evm.model.AC_000164.1.766 Q9Y2X0 MED16_HUMAN 94.297 0.284783 1.04903 MED16 - Mediator of RNA polymerase II transcription subunit 16 - Homo sapiens (Human) - MED16 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Taurus_UMD|evm.model.AC_000164.1.767 Q2KIL7 R3HD4_BOVIN 100.000 0.992674 1.00368 R3HDM4 - R3H domain-containing protein 4 - Bos taurus (Bovine) - R3HDM4 gene Taurus_UMD|evm.model.AC_000164.1.768 Q969F8 KISSR_HUMAN 83.820 0.992084 0.952261 KISS1R - KiSS-1 receptor - Homo sapiens (Human) - KISS1R gene Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. Taurus_UMD|evm.model.AC_000164.1.769 Q99856 ARI3A_HUMAN 82.500 0.996616 0.996627 ARID3A - AT-rich interactive domain-containing protein 3A - Homo sapiens (Human) - ARID3A gene Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. Taurus_UMD|evm.model.AC_000164.1.770 Q3SZD4 WDR18_BOVIN 100.000 0.968539 1.03009 WDR18 - WD repeat-containing protein 18 - Bos taurus (Bovine) - WDR18 gene Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity). May play a role during development (By similarity). Taurus_UMD|evm.model.AC_000164.1.771 O60391 NMD3B_HUMAN 89.189 0.07628 0.917546 GRIN3B - Glutamate receptor ionotropic, NMDA 3B precursor - Homo sapiens (Human) - GRIN3B gene NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. Taurus_UMD|evm.model.AC_000164.1.772 Q3TBD2 HMHA1_MOUSE 91.525 0.0826211 0.629032 Arhgap45 - Rho GTPase-activating protein 45 - Mus musculus (Mouse) - Arhgap45 gene Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. Taurus_UMD|evm.model.AC_000164.1.773 Q3SYU6 CNN2_BOVIN 100.000 0.76738 1.21036 CNN2 - Calponin-2 - Bos taurus (Bovine) - CNN2 gene Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). Taurus_UMD|evm.model.AC_000164.1.774 Q8IZY2 ABCA7_HUMAN 82.462 0.999071 1.00326 ABCA7 - Phospholipid-transporting ATPase ABCA7 - Homo sapiens (Human) - ABCA7 gene Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791). Taurus_UMD|evm.model.AC_000164.1.775 Q92619 HMHA1_HUMAN 85.714 0.161253 0.758803 ARHGAP45 - Rho GTPase-activating protein 45 - Homo sapiens (Human) - ARHGAP45 gene Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. Taurus_UMD|evm.model.AC_000164.1.776 Q5R587 RPAB1_PONAB 99.524 0.990521 1.00476 POLR2E - DNA-directed RNA polymerases I, II, and III subunit RPABC1 - Pongo abelii (Sumatran orangutan) - POLR2E gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity). Taurus_UMD|evm.model.AC_000164.1.777 Q9N2J2 GPX4_BOVIN 92.893 0.98913 0.93401 GPX4 - Phospholipid hydroperoxide glutathione peroxidase precursor - Bos taurus (Bovine) - GPX4 gene Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity). Taurus_UMD|evm.model.AC_000164.1.778 A0JND4 SBNO2_BOVIN 100.000 0.998545 1.00073 SBNO2 - Protein strawberry notch homolog 2 - Bos taurus (Bovine) - SBNO2 gene Seems to have transcriptional repression activity in macrophages. Taurus_UMD|evm.model.AC_000164.1.779 Q15831 STK11_HUMAN 97.619 0.706215 0.408776 STK11 - Serine/threonine-protein kinase STK11 precursor - Homo sapiens (Human) - STK11 gene Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). Taurus_UMD|evm.model.AC_000164.1.780 Q15831 STK11_HUMAN 77.987 0.872928 0.418014 STK11 - Serine/threonine-protein kinase STK11 precursor - Homo sapiens (Human) - STK11 gene Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). Taurus_UMD|evm.model.AC_000164.1.781 Q15831 STK11_HUMAN 96.894 0.987654 0.374134 STK11 - Serine/threonine-protein kinase STK11 precursor - Homo sapiens (Human) - STK11 gene Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). Taurus_UMD|evm.model.AC_000164.1.782 Q8N350 CBARP_HUMAN 74.740 0.646992 1.24965 CBARP - Voltage-dependent calcium channel beta subunit-associated regulatory protein - Homo sapiens (Human) - CBARP gene Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. Taurus_UMD|evm.model.AC_000164.1.783 P05630 ATPD_BOVIN 100.000 0.988166 1.00595 ATP5F1D - ATP synthase subunit delta, mitochondrial precursor - Bos taurus (Bovine) - ATP5F1D gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Taurus_UMD|evm.model.AC_000164.1.784 O43921 EFNA2_HUMAN 96.244 0.990654 1.00469 EFNA2 - Ephrin-A2 precursor - Homo sapiens (Human) - EFNA2 gene Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity). Taurus_UMD|evm.model.AC_000164.1.785 D4AE48 MIDN_RAT 86.275 0.995976 0.984158 Midn - Midnolin - Rattus norvegicus (Rat) - Midn gene Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion (PubMed:24187134). Taurus_UMD|evm.model.AC_000164.1.786 Q5RF83 CIRBP_PONAB 98.214 0.36087 2.67442 CIRBP - Cold-inducible RNA-binding protein - Pongo abelii (Sumatran orangutan) - CIRBP gene Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed (By similarity). Taurus_UMD|evm.model.AC_000164.1.788 Q08DK9 PWP3A_BOVIN 100.000 0.996885 1.00156 PWWP3A - PWWP domain-containing DNA repair factor 3A - Bos taurus (Bovine) - PWWP3A gene Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage (By similarity). Taurus_UMD|evm.model.AC_000164.1.789 P42026 NDUS7_BOVIN 100.000 0.990783 1.00463 NDUFS7 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial precursor - Bos taurus (Bovine) - NDUFS7 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:10852722, PubMed:18721790). Essential for the catalytic activity of complex I (By similarity). Taurus_UMD|evm.model.AC_000164.1.790 Q2TBQ3 GAMT_BOVIN 100.000 0.991561 1.00424 GAMT - Guanidinoacetate N-methyltransferase - Bos taurus (Bovine) - GAMT gene Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development. Taurus_UMD|evm.model.AC_000164.1.791 Q96EP5 DAZP1_HUMAN 98.250 0.970732 1.00737 DAZAP1 - DAZ-associated protein 1 - Homo sapiens (Human) - DAZAP1 gene RNA-binding protein, which may be required during spermatogenesis. Taurus_UMD|evm.model.AC_000164.1.792 Q56K10 RS15_BOVIN 100.000 0.986301 1.0069 RPS15 - 40S ribosomal protein S15 - Bos taurus (Bovine) - RPS15 gene cytosolic small ribosomal subunit, structural constituent of ribosome, ribosomal small subunit assembly Taurus_UMD|evm.model.AC_000164.1.793 O95996 APCL_HUMAN 81.932 0.988586 0.989145 APC2 - Adenomatous polyposis coli protein 2 - Homo sapiens (Human) - APC2 gene Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329). Taurus_UMD|evm.model.AC_000164.1.794 Q1LZF3 CS025_BOVIN 100.000 0.983193 1.00847 UPF0449 protein C19orf25 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000164.1.795 Q6UW60 PCSK4_HUMAN 78.682 0.941094 0.944371 PCSK4 - Proprotein convertase subtilisin/kexin type 4 precursor - Homo sapiens (Human) - PCSK4 gene Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed:16040806). May also participate in folliculogenesis in the ovaries (By similarity). Taurus_UMD|evm.model.AC_000164.1.796 Q32LG5 REEP6_BOVIN 100.000 0.380846 2.42703 REEP6 - Receptor expression-enhancing protein 6 - Bos taurus (Bovine) - REEP6 gene Required for correct function and survival of retinal photoreceptors (By similarity). Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity). Taurus_UMD|evm.model.AC_000164.1.797 Q6ZMM2 ATL5_HUMAN 82.938 0.517241 0.844075 ADAMTSL5 - ADAMTS-like protein 5 precursor - Homo sapiens (Human) - ADAMTSL5 gene May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM). Taurus_UMD|evm.model.AC_000164.1.798 O95983 MBD3_HUMAN 96.610 0.765217 0.790378 MBD3 - Methyl-CpG-binding domain protein 3 - Homo sapiens (Human) - MBD3 gene Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. Taurus_UMD|evm.model.AC_000164.1.799 O95983 MBD3_HUMAN 92.593 0.546392 0.333333 MBD3 - Methyl-CpG-binding domain protein 3 - Homo sapiens (Human) - MBD3 gene Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. Taurus_UMD|evm.model.AC_000164.1.800 P07552 QCR10_BOVIN 100.000 0.964912 1.01786 UQCR11 - Cytochrome b-c1 complex subunit 10 - Bos taurus (Bovine) - UQCR11 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. QCR10 has a role in CIII assembly and RIP1 stability. Taurus_UMD|evm.model.AC_000164.1.801 P15923 TFE2_HUMAN 79.389 0.996875 0.978593 TCF3 - Transcription factor E2-alpha - Homo sapiens (Human) - TCF3 gene Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Together with TCF15, required for the mesenchymal to epithelial transition. Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). Taurus_UMD|evm.model.AC_000164.1.802 Q8K557 ONEC3_MOUSE 98.734 0.521595 0.614286 Onecut3 - One cut domain family member 3 - Mus musculus (Mouse) - Onecut3 gene Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Taurus_UMD|evm.model.AC_000164.1.803 O60423 AT8B3_HUMAN 72.213 0.871977 1.08154 ATP8B3 - Phospholipid-transporting ATPase IK - Homo sapiens (Human) - ATP8B3 gene P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida. Taurus_UMD|evm.model.AC_000164.1.804 Q8N1G1 REXO1_HUMAN 78.409 0.99835 0.992629 REXO1 - RNA exonuclease 1 homolog - Homo sapiens (Human) - REXO1 gene Seems to have no detectable effect on transcription elongation in vitro. Taurus_UMD|evm.model.AC_000164.1.805 Q9BXK1 KLF16_HUMAN 92.793 0.662651 0.65873 KLF16 - Krueppel-like factor 16 - Homo sapiens (Human) - KLF16 gene Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). Taurus_UMD|evm.model.AC_000164.1.806 Q2HJ19 AB17A_BOVIN 99.677 0.993569 1.00323 ABHD17A - Alpha/beta hydrolase domain-containing protein 17A - Bos taurus (Bovine) - ABHD17A gene Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6. Taurus_UMD|evm.model.AC_000164.1.807 Q96EY9 ADAT3_HUMAN 82.440 0.956395 0.980057 ADAT3 - Probable inactive tRNA-specific adenosine deaminase-like protein 3 - Homo sapiens (Human) - ADAT3 gene nucleoplasm, tRNA modification Taurus_UMD|evm.model.AC_000164.1.808 Q58DF6 SCAM4_BOVIN 100.000 0.991342 1.00435 SCAMP4 - Secretory carrier-associated membrane protein 4 - Bos taurus (Bovine) - SCAMP4 gene Probably involved in membrane protein trafficking. Taurus_UMD|evm.model.AC_000164.1.810 P78368 KC1G2_HUMAN 95.663 0.995181 1 CSNK1G2 - Casein kinase I isoform gamma-2 - Homo sapiens (Human) - CSNK1G2 gene Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation. Taurus_UMD|evm.model.AC_000164.1.811 Q9BX70 BTBD2_HUMAN 96.231 0.884086 0.969524 BTBD2 - BTB/POZ domain-containing protein 2 - Homo sapiens (Human) - BTBD2 gene cytosol, P-body, neurogenesis Taurus_UMD|evm.model.AC_000164.1.812 Q2M3V2 SWAHA_HUMAN 77.473 0.964539 1.02732 SOWAHA - Ankyrin repeat domain-containing protein SOWAHA precursor - Homo sapiens (Human) - SOWAHA gene Taurus_UMD|evm.model.AC_000164.1.813 Q2M3G4 SHRM1_HUMAN 71.028 0.992891 0.99061 SHROOM1 - Protein Shroom1 - Homo sapiens (Human) - SHROOM1 gene May be involved in the assembly of microtubule arrays during cell elongation. Taurus_UMD|evm.model.AC_000164.1.814 Q9GK68 GDF9_BOVIN 100.000 0.994536 0.807947 GDF9 - Growth/differentiation factor 9 precursor - Bos taurus (Bovine) - GDF9 gene Required for ovarian folliculogenesis. Taurus_UMD|evm.model.AC_000164.1.815 P13271 QCR8_BOVIN 100.000 0.604478 1.63415 UQCRQ - Cytochrome b-c1 complex subunit 8 - Bos taurus (Bovine) - UQCRQ gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Taurus_UMD|evm.model.AC_000164.1.816 Q9UHB7 AFF4_HUMAN 96.134 0.980607 1.01978 AFF4 - AF4/FMR2 family member 4 - Homo sapiens (Human) - AFF4 gene Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. Taurus_UMD|evm.model.AC_000164.1.817 Q9CX48 ZCH10_MOUSE 93.333 0.432749 0.960674 Zcchc10 - Zinc finger CCHC domain-containing protein 10 - Mus musculus (Mouse) - Zcchc10 gene Taurus_UMD|evm.model.AC_000164.1.818 Q58DW5 RL5_BOVIN 95.726 0.885496 0.441077 RPL5 - 60S ribosomal protein L5 - Bos taurus (Bovine) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Taurus_UMD|evm.model.AC_000164.1.819 P34932 HSP74_HUMAN 97.619 0.997622 1.00119 HSPA4 - Heat shock 70 kDa protein 4 - Homo sapiens (Human) - HSPA4 gene cytosol, extracellular exosome, nucleus, ATP binding, chaperone-mediated protein complex assembly, protein insertion into mitochondrial outer membrane, response to unfolded protein Taurus_UMD|evm.model.AC_000164.1.820 Q6MZW2 FSTL4_HUMAN 80.377 0.967949 0.926366 FSTL4 - Follistatin-related protein 4 precursor - Homo sapiens (Human) - FSTL4 gene cell differentiation, multicellular organism development Taurus_UMD|evm.model.AC_000164.1.823 Q5R5B8 KCT2_PONAB 78.113 0.992453 1 KCT2 - Keratinocyte-associated transmembrane protein 2 precursor - Pongo abelii (Sumatran orangutan) - KCT2 gene Taurus_UMD|evm.model.AC_000164.1.824 Q9TT15 VDAC1_RABIT 100.000 0.992958 1.00353 VDAC1 - Voltage-dependent anion-selective channel protein 1 - Oryctolagus cuniculus (Rabbit) - VDAC1 gene Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol. In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. May mediate ATP export from cells. Taurus_UMD|evm.model.AC_000164.1.825 P36402 TCF7_HUMAN 91.160 0.928021 1.01302 TCF7 - Transcription factor 7 - Homo sapiens (Human) - TCF7 gene Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. Taurus_UMD|evm.model.AC_000164.1.826 Q71U00 SKP1_XENLA 100.000 0.987805 1.00613 skp1 - S-phase kinase-associated protein 1 - Xenopus laevis (African clawed frog) - skp1 gene Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). Taurus_UMD|evm.model.AC_000164.1.827 P67777 PP2AA_RABIT 100.000 0.993548 1.00324 PPP2CA - Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform - Oryctolagus cuniculus (Rabbit) - PPP2CA gene PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (By similarity). Taurus_UMD|evm.model.AC_000164.1.828 Q4R8T9 CDKL3_MACFA 84.669 0.965928 0.994915 CDKL3 - Cyclin-dependent kinase-like 3 - Macaca fascicularis (Crab-eating macaque) - CDKL3 gene Taurus_UMD|evm.model.AC_000164.1.829 P63149 UBE2B_RAT 100.000 0.986928 1.00658 Ube2b - Ubiquitin-conjugating enzyme E2 B - Rattus norvegicus (Rat) - Ube2b gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth. Taurus_UMD|evm.model.AC_000164.1.830 Q24JY8 C2AIL_BOVIN 100.000 0.982906 1.00862 CDKN2AIPNL - CDKN2AIP N-terminal-like protein - Bos taurus (Bovine) - CDKN2AIPNL gene nucleolus, nucleoplasm Taurus_UMD|evm.model.AC_000164.1.831 Q6ZQF7 JADE2_MOUSE 90.264 0.958237 1.03981 Jade2 - E3 ubiquitin-protein ligase Jade-2 - Mus musculus (Mouse) - Jade2 gene Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (By similarity). Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself (PubMed:25018020). Positive regulator of neurogenesis (PubMed:25018020). Taurus_UMD|evm.model.AC_000164.1.832 Q3T0T7 SAR1B_BOVIN 100.000 0.98995 1.00505 SAR1B - GTP-binding protein SAR1b - Bos taurus (Bovine) - SAR1B gene Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity). Taurus_UMD|evm.model.AC_000164.1.833 A6QNT8 SC24A_BOVIN 100.000 0.998182 1.00091 SEC24A - Protein transport protein Sec24A - Bos taurus (Bovine) - SEC24A gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes. Taurus_UMD|evm.model.AC_000164.1.834 P49069 CAMLG_HUMAN 93.515 0.993174 0.989865 CAMLG - Guided entry of tail-anchored proteins factor CAMLG - Homo sapiens (Human) - CAMLG gene Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539). Required for the stability of GET1 (PubMed:32187542). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304). Essential for the survival of peripheral follicular B cells (By similarity). Taurus_UMD|evm.model.AC_000164.1.835 Q7L014 DDX46_HUMAN 99.607 0.842454 1.16974 DDX46 - Probable ATP-dependent RNA helicase DDX46 - Homo sapiens (Human) - DDX46 gene Plays an essential role in splicing, either prior to, or during splicing A complex formation. Taurus_UMD|evm.model.AC_000164.1.836 Q96J42 TXD15_HUMAN 86.479 0.876238 1.12222 TXNDC15 - Thioredoxin domain-containing protein 15 precursor - Homo sapiens (Human) - TXNDC15 gene Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Involved in ciliogenesis (PubMed:27894351). Taurus_UMD|evm.model.AC_000164.1.837 Q9H0N5 PHS2_HUMAN 89.623 0.981308 0.823077 PCBD2 - Pterin-4-alpha-carbinolamine dehydratase 2 - Homo sapiens (Human) - PCBD2 gene Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Taurus_UMD|evm.model.AC_000164.1.838 Q86XQ3 CTSR3_HUMAN 78.000 0.993355 0.756281 CATSPER3 - Cation channel sperm-associated protein 3 - Homo sapiens (Human) - CATSPER3 gene Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Taurus_UMD|evm.model.AC_000164.1.839 P78337 PITX1_HUMAN 98.408 0.808786 1.23248 PITX1 - Pituitary homeobox 1 - Homo sapiens (Human) - PITX1 gene Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Taurus_UMD|evm.model.AC_000164.1.840 O75367 H2AY_HUMAN 99.194 0.994624 1 MACROH2A1 - Core histone macro-H2A.1 - Homo sapiens (Human) - MACROH2A1 gene Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16428466, PubMed:16107708). Taurus_UMD|evm.model.AC_000164.1.841 Q6ZNK6 TIFAB_HUMAN 77.019 0.717489 1.38509 TIFAB - TRAF-interacting protein with FHA domain-containing protein B - Homo sapiens (Human) - TIFAB gene Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA. Taurus_UMD|evm.model.AC_000164.1.842 Q92886 NGN1_HUMAN 85.830 0.991935 1.04641 NEUROG1 - Neurogenin-1 - Homo sapiens (Human) - NEUROG1 gene Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). Taurus_UMD|evm.model.AC_000164.1.843 O95715 CXL14_HUMAN 97.590 0.82 0.900901 CXCL14 - C-X-C motif chemokine 14 precursor - Homo sapiens (Human) - CXCL14 gene Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. Taurus_UMD|evm.model.AC_000164.1.845 Q3MHI3 S2548_BOVIN 99.678 0.945122 1.05466 SLC25A48 - Solute carrier family 25 member 48 - Bos taurus (Bovine) - SLC25A48 gene acyl carnitine transmembrane transporter activity, acyl carnitine transport, amino acid transport Taurus_UMD|evm.model.AC_000164.1.846 P15248 IL9_HUMAN 58.993 0.971831 0.986111 IL9 - Interleukin-9 precursor - Homo sapiens (Human) - IL9 gene Supports IL-2 independent and IL-4 independent growth of helper T-cells. Taurus_UMD|evm.model.AC_000164.1.847 Q3ZBA7 FXL21_BOVIN 100.000 0.949561 1.05069 FBXL21 - F-box/LRR-repeat protein 21 - Bos taurus (Bovine) - FBXL21 gene Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity). Taurus_UMD|evm.model.AC_000164.1.848 O62644 LECT2_BOVIN 100.000 0.986842 1.00662 LECT2 - Leukocyte cell-derived chemotaxin-2 precursor - Bos taurus (Bovine) - LECT2 gene Has a neutrophil chemotactic activity (PubMed:9524238). Also a positive regulator of chondrocyte proliferation (PubMed:10050029, PubMed:8798437). Taurus_UMD|evm.model.AC_000164.1.849 P55906 BGH3_BOVIN 100.000 0.987597 0.944363 TGFBI - Transforming growth factor-beta-induced protein ig-h3 precursor - Bos taurus (Bovine) - TGFBI gene Plays a role in cell adhesion (By similarity). May play a role in cell-collagen interactions (By similarity). Taurus_UMD|evm.model.AC_000164.1.850 P0CG89 H4_SOYBN 84.375 0.346154 1.76699 Histone H4 - Glycine max (Soybean) Taurus_UMD|evm.model.AC_000164.1.851 Q5R6H7 SMAD5_PONAB 100.000 0.995708 1.00215 SMAD5 - Mothers against decapentaplegic homolog 5 - Pongo abelii (Sumatran orangutan) - SMAD5 gene Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD) (By similarity). Taurus_UMD|evm.model.AC_000164.1.852 A0A1B0GUA5 SIM32_HUMAN 92.233 0.980769 1.00971 SMIM32 - Small integral membrane protein 32 - Homo sapiens (Human) - SMIM32 gene Taurus_UMD|evm.model.AC_000164.1.854 Q9HCX4 TRPC7_HUMAN 97.213 0.777778 0.908353 TRPC7 - Short transient receptor potential channel 7 - Homo sapiens (Human) - TRPC7 gene Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion. Taurus_UMD|evm.model.AC_000164.1.856 Q08629 TICN1_HUMAN 94.430 0.994709 0.861048 SPOCK1 - Testican-1 precursor - Homo sapiens (Human) - SPOCK1 gene May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system. Taurus_UMD|evm.model.AC_000164.1.858 Q08629 TICN1_HUMAN 93.548 0.484127 0.287016 SPOCK1 - Testican-1 precursor - Homo sapiens (Human) - SPOCK1 gene May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system. Taurus_UMD|evm.model.AC_000164.1.859 F1MBP6 KLHL3_BOVIN 100.000 0.996599 1.0017 KLHL3 - Kelch-like protein 3 - Bos taurus (Bovine) - KLHL3 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity). Taurus_UMD|evm.model.AC_000164.1.860 Q13151 ROA0_HUMAN 99.020 0.993464 1.00328 HNRNPA0 - Heterogeneous nuclear ribonucleoprotein A0 - Homo sapiens (Human) - HNRNPA0 gene mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs. Taurus_UMD|evm.model.AC_000164.1.861 Q9UBF9 MYOTI_HUMAN 92.369 0.616625 1.61847 MYOT - Myotilin - Homo sapiens (Human) - MYOT gene Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells. Taurus_UMD|evm.model.AC_000164.1.863 Q9NZM6 PK2L2_HUMAN 85.417 0.99362 1.00481 PKD2L2 - Polycystic kidney disease 2-like 2 protein - Homo sapiens (Human) - PKD2L2 gene May function as a subunit of a cation channel and play a role in fertilization. Taurus_UMD|evm.model.AC_000164.1.864 Q9NYF5 FA13B_HUMAN 96.313 0.519185 0.911475 FAM13B - Protein FAM13B - Homo sapiens (Human) - FAM13B gene cytosol, regulation of small GTPase mediated signal transduction Taurus_UMD|evm.model.AC_000164.1.866 Q9H1J5 WNT8A_HUMAN 91.168 0.994318 1.00285 WNT8A - Protein Wnt-8a precursor - Homo sapiens (Human) - WNT8A gene Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. Taurus_UMD|evm.model.AC_000164.1.867 P56597 NDK5_HUMAN 91.388 0.41517 2.36321 NME5 - Nucleoside diphosphate kinase homolog 5 - Homo sapiens (Human) - NME5 gene Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity). Taurus_UMD|evm.model.AC_000164.1.868 Q9H0E9 BRD8_HUMAN 97.222 0.225603 0.77166 BRD8 - Bromodomain-containing protein 8 - Homo sapiens (Human) - BRD8 gene May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Taurus_UMD|evm.model.AC_000164.1.869 A1A4R8 CDC23_BOVIN 98.725 0.978571 0.938023 CDC23 - Cell division cycle protein 23 homolog - Bos taurus (Bovine) - CDC23 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Taurus_UMD|evm.model.AC_000164.1.870 O60609 GFRA3_HUMAN 82.749 0.936709 0.9875 GFRA3 - GDNF family receptor alpha-3 precursor - Homo sapiens (Human) - GFRA3 gene Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. Taurus_UMD|evm.model.AC_000164.1.871 A5D7P0 MPIP3_BOVIN 89.308 0.995316 0.895178 CDC25C - M-phase inducer phosphatase 3 - Bos taurus (Bovine) - CDC25C gene Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activate its kinase activity (By similarity). Taurus_UMD|evm.model.AC_000164.1.872 Q9YGP6 SLBP2_XENLA 76.471 0.175532 0.752 slbp2 - Oocyte-specific histone RNA stem-loop-binding protein 2 - Xenopus laevis (African clawed frog) - slbp2 gene Binds the stem-loop structure of replication-dependent histone mRNAs. Is associated with translationally inactive histone mRNA stored in oocytes. Could be a specific translational repressor. Not involved in histone pre-mRNA processing. Taurus_UMD|evm.model.AC_000164.1.873 Q29RM2 FA53C_BOVIN 100.000 0.994911 1.00255 FAM53C - Protein FAM53C - Bos taurus (Bovine) - FAM53C gene nucleus, protein import into nucleus Taurus_UMD|evm.model.AC_000164.1.874 Q7LBC6 KDM3B_HUMAN 96.313 0.998864 0.999432 KDM3B - Lysine-specific demethylase 3B - Homo sapiens (Human) - KDM3B gene Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. Taurus_UMD|evm.model.AC_000164.1.875 Q2KI30 REEP2_BOVIN 100.000 0.992157 1.00394 REEP2 - Receptor expression-enhancing protein 2 - Bos taurus (Bovine) - REEP2 gene Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity). Taurus_UMD|evm.model.AC_000164.1.876 Q29W20 EGR1_BOVIN 99.262 0.996317 1.00556 EGR1 - Early growth response protein 1 - Bos taurus (Bovine) - EGR1 gene Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). Taurus_UMD|evm.model.AC_000164.1.877 Q5U2Q7 ERF1_RAT 100.000 0.995434 1.00229 Etf1 - Eukaryotic peptide chain release factor subunit 1 - Rattus norvegicus (Rat) - Etf1 gene Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Taurus_UMD|evm.model.AC_000164.1.878 Q3ZCH0 GRP75_BOVIN 100.000 0.997059 1.00147 HSPA9 - Stress-70 protein, mitochondrial precursor - Bos taurus (Bovine) - HSPA9 gene Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis probably via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Taurus_UMD|evm.model.AC_000164.1.879 Q58DW2 CGL_BOVIN 99.506 0.995074 1.00247 CTH - Cystathionine gamma-lyase - Bos taurus (Bovine) - CTH gene Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (By similarity). Taurus_UMD|evm.model.AC_000164.1.880 Q3MHM6 CTNA1_BOVIN 99.779 0.983696 1.01545 CTNNA1 - Catenin alpha-1 - Bos taurus (Bovine) - CTNNA1 gene Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation (By similarity). Taurus_UMD|evm.model.AC_000164.1.881 Q32KV6 SIL1_BOVIN 100.000 0.99568 1.00216 SIL1 - Nucleotide exchange factor SIL1 precursor - Bos taurus (Bovine) - SIL1 gene Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5 (By similarity). Taurus_UMD|evm.model.AC_000164.1.883 P43243 MATR3_HUMAN 93.311 0.997773 1.06021 MATR3 - Matrin-3 - Homo sapiens (Human) - MATR3 gene May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). May bind to specific miRNA hairpins (PubMed:28431233). Taurus_UMD|evm.model.AC_000164.1.886 Q3ZC67 PAIP2_BOVIN 100.000 0.984 1.00806 PAIP2 - Polyadenylate-binding protein-interacting protein 2 - Bos taurus (Bovine) - PAIP2 gene Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (By similarity). Taurus_UMD|evm.model.AC_000164.1.887 Q9Z2J0 S23A1_MOUSE 92.088 0.967267 1.00992 Slc23a1 - Solute carrier family 23 member 1 - Mus musculus (Mouse) - Slc23a1 gene Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (By similarity). Taurus_UMD|evm.model.AC_000164.1.888 A5PJ93 MZB1_BOVIN 100.000 0.989474 1.00529 MZB1 - Marginal zone B- and B1-cell-specific protein precursor - Bos taurus (Bovine) - MZB1 gene Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation (By similarity). Taurus_UMD|evm.model.AC_000164.1.889 E7EW31 PROB1_HUMAN 73.190 0.998037 1.00394 PROB1 - Proline-rich basic protein 1 - Homo sapiens (Human) - PROB1 gene nucleoplasm Taurus_UMD|evm.model.AC_000164.1.890 Q4R7I4 SPA24_MACFA 94.634 0.990291 1.00488 SPATA24 - Spermatogenesis-associated protein 24 - Macaca fascicularis (Crab-eating macaque) - SPATA24 gene Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity). Taurus_UMD|evm.model.AC_000164.1.891 Q5EA26 DJC18_BOVIN 100.000 0.994429 1.00279 DNAJC18 - DnaJ homolog subfamily C member 18 - Bos taurus (Bovine) - DNAJC18 gene endoplasmic reticulum membrane, Hsp70 protein binding, cellular response to misfolded protein, chaperone cofactor-dependent protein refolding, ubiquitin-dependent ERAD pathway Taurus_UMD|evm.model.AC_000164.1.892 Q2KIX5 ECSCR_BOVIN 84.914 0.939024 1.24873 ECSCR - Endothelial cell-specific chemotaxis regulator precursor - Bos taurus (Bovine) - ECSCR gene Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2 (By similarity). Taurus_UMD|evm.model.AC_000164.1.893 A0A1B0GW64 SIM33_HUMAN 69.630 0.984962 1.00758 SMIM33 - Small integral membrane protein 33 - Homo sapiens (Human) - SMIM33 gene Taurus_UMD|evm.model.AC_000164.1.894 Q2KI99 STING_BOVIN 100.000 0.994723 1.00265 STING1 - Stimulator of interferon genes protein - Bos taurus (Bovine) - STING1 gene Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of c-di-GMP or cGAMP, STING oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state. In addition to promote the production of type I interferons, plays a direct role in autophagy. Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). The ERGIC serves as the membrane source for WIPI2 recruitment and LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome. The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation (By similarity). Autophagy is also triggered upon infection by bacteria: following c-di-GMP-binding, which is produced by live Gram-positive bacteria, promotes reticulophagy (By similarity). Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP (2'-3'-cGAMP) and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP. The preference for 2'-3'-cGAMP, compared to other linkage isomers is probably due to the ligand itself, whichs adopts an organized free-ligand conformation that resembles the STING1-bound conformation and pays low energy costs in changing into the active conformation. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons (By similarity). May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) (By similarity). Taurus_UMD|evm.model.AC_000164.1.895 P62840 UB2D2_XENLA 100.000 0.986486 1.0068 ube2d2 - Ubiquitin-conjugating enzyme E2 D2 - Xenopus laevis (African clawed frog) - ube2d2 gene Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Taurus_UMD|evm.model.AC_000164.1.896 Q32LB3 CXXC5_BOVIN 100.000 0.993711 1.00315 CXXC5 - CXXC-type zinc finger protein 5 - Bos taurus (Bovine) - CXXC5 gene May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity). Taurus_UMD|evm.model.AC_000164.1.897 Q9BQI7 PSD2_HUMAN 89.359 0.997429 1.00908 PSD2 - PH and SEC7 domain-containing protein 2 - Homo sapiens (Human) - PSD2 gene cleavage furrow, ruffle membrane Taurus_UMD|evm.model.AC_000164.1.898 O14511 NRG2_HUMAN 94.612 0.892344 0.983529 NRG2 - Pro-neuregulin-2, membrane-bound isoform precursor - Homo sapiens (Human) - NRG2 gene Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. Taurus_UMD|evm.model.AC_000164.1.899 Q00577 PURA_HUMAN 99.068 0.993808 1.00311 PURA - Transcriptional activator protein Pur-alpha - Homo sapiens (Human) - PURA gene This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination. Taurus_UMD|evm.model.AC_000164.1.900 Q32LK2 CYTM1_BOVIN 84.466 0.971429 1.01942 CYSTM1 - Cysteine-rich and transmembrane domain-containing protein 1 - Bos taurus (Bovine) - CYSTM1 gene Taurus_UMD|evm.model.AC_000164.1.902 Q01580 HBEGF_PIG 90.865 0.990431 1.00481 HBEGF - Proheparin-binding EGF-like growth factor precursor - Sus scrofa (Pig) - HBEGF gene Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). Taurus_UMD|evm.model.AC_000164.1.903 Q96Q91 B3A4_HUMAN 85.021 0.969538 0.968464 SLC4A9 - Anion exchange protein 4 - Homo sapiens (Human) - SLC4A9 gene Probable apical anion exchanger of the kidney cortex. Taurus_UMD|evm.model.AC_000164.1.904 Q8IWZ3 ANKH1_HUMAN 95.089 0.957248 1.0122 ANKHD1 - Ankyrin repeat and KH domain-containing protein 1 - Homo sapiens (Human) - ANKHD1 gene May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. Taurus_UMD|evm.model.AC_000164.1.905 Q9HD15 SRA1_HUMAN 85.268 0.982379 0.961864 SRA1 - Steroid receptor RNA activator 1 - Homo sapiens (Human) - SRA1 gene Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. Taurus_UMD|evm.model.AC_000164.1.906 O95704 APBB3_HUMAN 94.033 0.995893 1.00206 APBB3 - Amyloid-beta A4 precursor protein-binding family B member 3 - Homo sapiens (Human) - APBB3 gene May modulate the internalization of amyloid-beta precursor protein. Taurus_UMD|evm.model.AC_000164.1.907 L0R6Q1 S35U4_HUMAN 93.204 0.980769 1.00971 SLC35A4 - SLC35A4 upstream open reading frame protein - Homo sapiens (Human) - SLC35A4 gene positive regulation of translation in response to stress Taurus_UMD|evm.model.AC_000164.1.908 Q05B73 S35A4_BOVIN 100.000 0.993846 1.00309 SLC35A4 - Probable UDP-sugar transporter protein SLC35A4 - Bos taurus (Bovine) - SLC35A4 gene Golgi apparatus, integral component of Golgi membrane Taurus_UMD|evm.model.AC_000164.1.910 Q95122 CD14_BOVIN 100.000 0.994652 1.00268 CD14 - Monocyte differentiation antigen CD14 precursor - Bos taurus (Bovine) - CD14 gene Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity). Taurus_UMD|evm.model.AC_000164.1.911 Q96DC7 TMCO6_HUMAN 87.018 0.995951 1.00203 TMCO6 - Transmembrane and coiled-coil domain-containing protein 6 - Homo sapiens (Human) - TMCO6 gene Taurus_UMD|evm.model.AC_000164.1.912 Q02370 NDUA2_BOVIN 100.000 0.98 1.0101 NDUFA2 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 - Bos taurus (Bovine) - NDUFA2 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000164.1.913 Q58DT8 WDR55_BOVIN 100.000 0.409677 2.43455 WDR55 - WD repeat-containing protein 55 - Bos taurus (Bovine) - WDR55 gene Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). Taurus_UMD|evm.model.AC_000164.1.914 Q8IYX4 DND1_HUMAN 89.577 0.994382 1.0085 DND1 - Dead end protein homolog 1 - Homo sapiens (Human) - DND1 gene RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity). Taurus_UMD|evm.model.AC_000164.1.915 Q2KI84 HARS1_BOVIN 100.000 0.996078 1.00196 HARS1 - Histidine--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - HARS1 gene Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Taurus_UMD|evm.model.AC_000164.1.916 A5D7V9 SYHM_BOVIN 99.802 0.996055 1.00198 HARS2 - Histidine--tRNA ligase, mitochondrial precursor - Bos taurus (Bovine) - HARS2 gene Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Taurus_UMD|evm.model.AC_000164.1.917 Q9CPW7 ZMAT2_MOUSE 100.000 0.99 1.00503 Zmat2 - Zinc finger matrin-type protein 2 - Mus musculus (Mouse) - Zmat2 gene Involved in pre-mRNA splicing as a component of the spliceosome. Taurus_UMD|evm.model.AC_000164.1.918 Q9Y5I0 PCDAD_HUMAN 44.586 0.947368 0.16 PCDHA13 - Protocadherin alpha-13 precursor - Homo sapiens (Human) - PCDHA13 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.919 Q9Y5H7 PCDA5_HUMAN 85.151 0.16 5.07479 PCDHA5 - Protocadherin alpha-5 precursor - Homo sapiens (Human) - PCDHA5 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.920 Q9Y5I2 PCDAA_HUMAN 84.556 0.497436 1.64557 PCDHA10 - Protocadherin alpha-10 precursor - Homo sapiens (Human) - PCDHA10 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.921 Q91Y20 PCDAA_MOUSE 81.137 0.959057 0.852008 Pcdha10 - Protocadherin alpha-10 precursor - Mus musculus (Mouse) - Pcdha10 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.922 Q9Y5I0 PCDAD_HUMAN 86.047 0.321414 2.53158 PCDHA13 - Protocadherin alpha-13 precursor - Homo sapiens (Human) - PCDHA13 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.923 Q9H158 PCDC1_HUMAN 83.847 0.989011 0.850467 PCDHAC1 - Protocadherin alpha-C1 precursor - Homo sapiens (Human) - PCDHAC1 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.924 Q60972 RBBP4_MOUSE 75.731 0.993197 0.691765 Rbbp4 - Histone-binding protein RBBP4 - Mus musculus (Mouse) - Rbbp4 gene Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Taurus_UMD|evm.model.AC_000164.1.925 Q9Y5I4 PCDC2_HUMAN 93.446 0.998008 0.997021 PCDHAC2 - Protocadherin alpha-C2 precursor - Homo sapiens (Human) - PCDHAC2 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.926 Q5DRE0 PCDB1_PANTR 88.753 0.997558 1.00122 PCDHB1 - Protocadherin beta-1 precursor - Pan troglodytes (Chimpanzee) - PCDHB1 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.927 Q3MI00 DNJB1_BOVIN 80.000 0.991597 0.7 DNAJB1 - DnaJ homolog subfamily B member 1 - Bos taurus (Bovine) - DNAJB1 gene Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Taurus_UMD|evm.model.AC_000164.1.928 Q5DRD2 PCDB2_PANTR 70.986 0.978788 0.413534 PCDHB2 - Protocadherin beta-2 precursor - Pan troglodytes (Chimpanzee) - PCDHB2 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.929 Q5DRD0 PCDB4_PANTR 85.176 0.997491 1.00252 PCDHB4 - Protocadherin beta-4 precursor - Pan troglodytes (Chimpanzee) - PCDHB4 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.930 Q5DRC9 PCDB5_PANTR 75.879 0.947917 0.724528 PCDHB5 - Protocadherin beta-5 precursor - Pan troglodytes (Chimpanzee) - PCDHB5 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.931 Q9Y5E3 PCDB6_HUMAN 82.642 0.994987 1.00504 PCDHB6 - Protocadherin beta-6 precursor - Homo sapiens (Human) - PCDHB6 gene Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.932 Q9Y5E4 PCDB5_HUMAN 80.024 0.997582 1.04025 PCDHB5 - Protocadherin beta-5 precursor - Homo sapiens (Human) - PCDHB5 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.933 Q5DRC3 PCDBH_PANTR 83.563 0.997494 1.00377 PCDHB17 - Protocadherin beta-17 precursor - Pan troglodytes (Chimpanzee) - PCDHB17 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.934 P60868 RS20_RAT 91.667 0.830986 0.596639 Rps20 - 40S ribosomal protein S20 - Rattus norvegicus (Rat) - Rps20 gene cytosolic small ribosomal subunit, small ribosomal subunit, synapse, structural constituent of ribosome Taurus_UMD|evm.model.AC_000164.1.935 Q9Y5E2 PCDB7_HUMAN 81.266 0.996134 0.978562 PCDHB7 - Protocadherin beta-7 precursor - Homo sapiens (Human) - PCDHB7 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.936 Q5DRC6 PCDB8_PANTR 82.420 0.992395 0.985019 PCDHB8 - Protocadherin beta-8 precursor - Pan troglodytes (Chimpanzee) - PCDHB8 gene Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.937 Q9NRJ7 PCDBG_HUMAN 84.819 0.97023 0.95232 PCDHB16 - Protocadherin beta-16 precursor - Homo sapiens (Human) - PCDHB16 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.938 Q5DRD9 PCDBA_PANTR 82.478 0.9975 1.00251 PCDHB10 - Protocadherin beta-10 precursor - Pan troglodytes (Chimpanzee) - PCDHB10 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.939 Q5DRD5 PCDBE_PANTR 85.419 0.516689 1.87719 PCDHB14 - Protocadherin beta-14 precursor - Pan troglodytes (Chimpanzee) - PCDHB14 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.940 Q5DRD4 PCDBI_PANTR 82.452 0.971142 1.01142 PCDHB18 - Protocadherin beta-18 precursor - Pan troglodytes (Chimpanzee) - PCDHB18 gene Potential calcium-dependent cell-adhesion protein. Taurus_UMD|evm.model.AC_000164.1.941 Q9Y5E8 PCDBF_HUMAN 83.312 0.983689 1.01271 PCDHB15 - Protocadherin beta-15 precursor - Homo sapiens (Human) - PCDHB15 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.942 A6YRY8 RSSA_SHEEP 80.952 0.976471 0.288136 RPSA - 40S ribosomal protein SA - Ovis aries (Sheep) - RPSA gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. Taurus_UMD|evm.model.AC_000164.1.943 Q9BXI2 ORNT2_HUMAN 86.711 0.993377 1.00332 SLC25A2 - Mitochondrial ornithine transporter 2 - Homo sapiens (Human) - SLC25A2 gene Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix. Taurus_UMD|evm.model.AC_000164.1.944 Q2HJG8 TAF7_BOVIN 99.713 0.994286 1.00287 TAF7 - Transcription initiation factor TFIID subunit 7 - Bos taurus (Bovine) - TAF7 gene Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). Taurus_UMD|evm.model.AC_000164.1.946 Q5DRC2 PCDG1_PANTR 81.660 0.992602 0.871106 PCDHGA1 - Protocadherin gamma-A1 precursor - Pan troglodytes (Chimpanzee) - PCDHGA1 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.947 Q5DRB8 PCDG2_PANTR 84.406 0.974607 0.887339 PCDHGA2 - Protocadherin gamma-A2 precursor - Pan troglodytes (Chimpanzee) - PCDHGA2 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.948 Q9Y5H0 PCDG3_HUMAN 86.634 0.508186 1.70386 PCDHGA3 - Protocadherin gamma-A3 precursor - Homo sapiens (Human) - PCDHGA3 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.949 Q9Y5G9 PCDG4_HUMAN 85.891 0.988971 0.848233 PCDHGA4 - Protocadherin gamma-A4 precursor - Homo sapiens (Human) - PCDHGA4 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.950 Q5DRA9 PCDGE_PANTR 84.015 0.915909 0.94522 PCDHGB2 - Protocadherin gamma-B2 precursor - Pan troglodytes (Chimpanzee) - PCDHGB2 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.951 Q9Y5G8 PCDG5_HUMAN 84.035 0.990184 0.875403 PCDHGA5 - Protocadherin gamma-A5 precursor - Homo sapiens (Human) - PCDHGA5 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.952 Q9Y5G1 PCDGF_HUMAN 81.282 0.966501 0.8676 PCDHGB3 - Protocadherin gamma-B3 precursor - Homo sapiens (Human) - PCDHGB3 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.953 Q9Y5G7 PCDG6_HUMAN 83.715 0.95716 0.876609 PCDHGA6 - Protocadherin gamma-A6 precursor - Homo sapiens (Human) - PCDHGA6 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.954 Q5DRB3 PCDG7_PANTR 81.504 0.966467 0.895923 PCDHGA7 - Protocadherin gamma-A7 precursor - Pan troglodytes (Chimpanzee) - PCDHGA7 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.955 Q9UN71 PCDGG_HUMAN 85.732 0.992537 0.871073 PCDHGB4 - Protocadherin gamma-B4 precursor - Homo sapiens (Human) - PCDHGB4 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.956 Q5DRB2 PCDG8_PANTR 84.204 0.991358 0.869099 PCDHGA8 - Protocadherin gamma-A8 precursor - Pan troglodytes (Chimpanzee) - PCDHGA8 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.957 Q9Y5G0 PCDGH_HUMAN 88.722 0.987608 0.874323 PCDHGB5 - Protocadherin gamma-B5 precursor - Homo sapiens (Human) - PCDHGB5 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.958 Q9Y5F9 PCDGI_HUMAN 87.931 0.478095 1.69355 PCDHGB6 - Protocadherin gamma-B6 precursor - Homo sapiens (Human) - PCDHGB6 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.959 Q5DRC1 PCDGA_PANTR 88.916 0.974576 0.882479 PCDHGA10 - Protocadherin gamma-A10 precursor - Pan troglodytes (Chimpanzee) - PCDHGA10 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.960 Q5DRA5 PCDGJ_PANTR 83.519 0.993827 0.871905 PCDHGB7 - Protocadherin gamma-B7 precursor - Pan troglodytes (Chimpanzee) - PCDHGB7 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.961 Q5DRC0 PCDGB_PANTR 85.120 0.96 0.882353 PCDHGA11 - Protocadherin gamma-A11 precursor - Pan troglodytes (Chimpanzee) - PCDHGA11 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.962 Q5DRB0 PCDGD_PANTR 68.099 0.996473 0.61165 PCDHGB1 - Protocadherin gamma-B1 precursor - Pan troglodytes (Chimpanzee) - PCDHGB1 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.963 O60330 PCDGC_HUMAN 84.682 0.893096 0.963519 PCDHGA12 - Protocadherin gamma-A12 precursor - Homo sapiens (Human) - PCDHGA12 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.964 Q5DRA4 PCDGK_PANTR 93.218 0.967742 0.896146 PCDHGC3 - Protocadherin gamma-C3 precursor - Pan troglodytes (Chimpanzee) - PCDHGC3 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.965 Q5DRA3 PCDGL_PANTR 94.893 0.484076 1.84115 PCDHGC4 - Protocadherin gamma-C4 precursor - Pan troglodytes (Chimpanzee) - PCDHGC4 gene Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Taurus_UMD|evm.model.AC_000164.1.966 O15379 HDAC3_HUMAN 94.891 0.362416 1.74065 HDAC3 - Histone deacetylase 3 - Homo sapiens (Human) - HDAC3 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803). Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner (By similarity). During the activation phase, promotes the accumulation of ubiquitinated ARNTL/BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and ARNTL/BMAL1 (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Interacts with SETD5 (By similarity). Taurus_UMD|evm.model.AC_000164.1.967 Q2KI80 RELL2_BOVIN 100.000 0.993421 1.0033 RELL2 - RELT-like protein 2 - Bos taurus (Bovine) - RELL2 gene Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed. Taurus_UMD|evm.model.AC_000164.1.968 Q86WN1 FCSD1_HUMAN 92.630 0.997106 1.00145 FCHSD1 - F-BAR and double SH3 domains protein 1 - Homo sapiens (Human) - FCHSD1 gene Promotes actin polymerization mediated by SNX9 and WASL. Taurus_UMD|evm.model.AC_000164.1.969 Q8WWN8 ARAP3_HUMAN 90.722 0.553725 0.904145 ARAP3 - Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 - Homo sapiens (Human) - ARAP3 gene Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. Taurus_UMD|evm.model.AC_000164.1.970 Q08174 PCDH1_HUMAN 94.948 0.828843 1.19057 PCDH1 - Protocadherin-1 precursor - Homo sapiens (Human) - PCDH1 gene May be involved in cell-cell interaction processes and in cell adhesion. Taurus_UMD|evm.model.AC_000164.1.971 Q14154 DELE1_HUMAN 83.462 0.996161 1.01165 DELE1 - DAP3-binding cell death enhancer 1 precursor - Homo sapiens (Human) - DELE1 gene Key activator of the integrated stress response (ISR) following mitochondrial stress (PubMed:32132706, PubMed:32132707). In response to mitochondrial stress, cleaved by the protease OMA1, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (PubMed:32132706, PubMed:32132707). Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed:20563667). Taurus_UMD|evm.model.AC_000164.1.972 Q9NPG4 PCD12_HUMAN 87.142 0.958264 1.01182 PCDH12 - Protocadherin-12 precursor - Homo sapiens (Human) - PCDH12 gene Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell-cell adhesion (PubMed:21402705). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). Taurus_UMD|evm.model.AC_000164.1.973 Q9UBS8 RNF14_HUMAN 95.781 0.995789 1.00211 RNF14 - E3 ubiquitin-protein ligase RNF14 - Homo sapiens (Human) - RNF14 gene Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription. Taurus_UMD|evm.model.AC_000164.1.974 A4FV08 GNPI1_BOVIN 100.000 0.891641 1.11765 GNPDA1 - Glucosamine-6-phosphate isomerase 1 - Bos taurus (Bovine) - GNPDA1 gene Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity). Taurus_UMD|evm.model.AC_000164.1.977 Q9BT67 NFIP1_HUMAN 96.000 0.765385 1.17647 NDFIP1 - NEDD4 family-interacting protein 1 - Homo sapiens (Human) - NDFIP1 gene Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion (PubMed:26319551). Restricts the production of proinflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination and degradation of RORC (By similarity). Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become effector T-cells (By similarity). Negatively regulates RLR-mediated antiviral response by promoting SMURF1-mediated ubiquitination and subsequent degradation of MAVS (PubMed:23087404). Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus where it mediates KCNH2 degradation (PubMed:26363003). In cortical neurons, mediates the ubiquitination of the divalent metal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and iron toxicity (PubMed:19706893). Important for normal development of dendrites and dendritic spines in cortex (By similarity). Enhances the ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCH and is required for the nuclear localization of ubiquitinated BRAT1 (PubMed:25631046). Enhances the ITCH-mediated ubiquitination of MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 to ITCH (By similarity). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate (PubMed:20534535). Inhibits cell proliferation by promoting PTEN nuclear localization and changing its signaling specificity (PubMed:25801959). Taurus_UMD|evm.model.AC_000164.1.978 A2VDU1 SPY4_BOVIN 100.000 0.993333 1.00334 SPRY4 - Protein sprouty homolog 4 - Bos taurus (Bovine) - SPRY4 gene Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras (By similarity). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (By similarity). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (By similarity). Taurus_UMD|evm.model.AC_000164.1.980 P03968 FGF1_BOVIN 100.000 0.987179 1.00645 FGF1 - Fibroblast growth factor 1 precursor - Bos taurus (Bovine) - FGF1 gene Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis (By similarity). Taurus_UMD|evm.model.AC_000164.1.981 Q9UNA1 RHG26_HUMAN 97.775 0.937346 1 ARHGAP26 - Rho GTPase-activating protein 26 - Homo sapiens (Human) - ARHGAP26 gene GTPase-activating protein for RHOA and CDC42. Taurus_UMD|evm.model.AC_000164.1.982 P04150 GCR_HUMAN 93.734 0.997442 1.00644 NR3C1 - Glucocorticoid receptor - Homo sapiens (Human) - NR3C1 gene Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). Taurus_UMD|evm.model.AC_000164.1.984 Q2T9V7 PREY_BOVIN 77.011 0.858586 0.868421 PREY - Protein preY, mitochondrial precursor - Bos taurus (Bovine) - PREY gene glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex, GPI anchor biosynthetic process Taurus_UMD|evm.model.AC_000164.1.986 Q5E9E8 YIPF5_BOVIN 100.000 0.632099 1.57588 YIPF5 - Protein YIPF5 - Bos taurus (Bovine) - YIPF5 gene Plays a role in transport between endoplasmic reticulum and Golgi. Taurus_UMD|evm.model.AC_000164.1.987 A4FUC0 RM37_BOVIN 77.241 0.985915 0.335697 MRPL37 - 39S ribosomal protein L37, mitochondrial precursor - Bos taurus (Bovine) - MRPL37 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion Taurus_UMD|evm.model.AC_000164.1.988 Q68DU8 KCD16_HUMAN 98.364 0.995338 1.00234 KCTD16 - BTB/POZ domain-containing protein KCTD16 - Homo sapiens (Human) - KCTD16 gene Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). Taurus_UMD|evm.model.AC_000164.1.990 Q0VBB0 PRLD2_MOUSE 86.076 0.993671 0.892655 Prelid2 - PRELI domain-containing protein 2 - Mus musculus (Mouse) - Prelid2 gene mitochondrial intermembrane space, mitochondrion, phosphatidic acid transfer activity, phospholipid transport Taurus_UMD|evm.model.AC_000164.1.991 A6NFK2 GRCR2_HUMAN 86.694 0.991903 0.995968 GRXCR2 - Glutaredoxin domain-containing cysteine-rich protein 2 - Homo sapiens (Human) - GRXCR2 gene Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection. Taurus_UMD|evm.model.AC_000164.1.992 Q8TEC5 SH3R2_HUMAN 88.643 0.983539 1 SH3RF2 - E3 ubiquitin-protein ligase SH3RF2 - Homo sapiens (Human) - SH3RF2 gene Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19945436, PubMed:19389623). Taurus_UMD|evm.model.AC_000164.1.993 Q9P2J5 SYLC_HUMAN 92.177 0.998301 1.00085 LARS1 - Leucine--tRNA ligase, cytoplasmic - Homo sapiens (Human) - LARS1 gene Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. Taurus_UMD|evm.model.AC_000164.1.994 Q9P2N5 RBM27_HUMAN 96.887 0.998111 0.999057 RBM27 - RNA-binding protein 27 - Homo sapiens (Human) - RBM27 gene nucleus, RNA binding Taurus_UMD|evm.model.AC_000164.1.995 Q63955 PO4F3_MOUSE 99.704 0.9941 1.00296 Pou4f3 - POU domain, class 4, transcription factor 3 - Mus musculus (Mouse) - Pou4f3 gene Acts as a transcriptional activator (PubMed:8290353, PubMed:7935408). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:7935408). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (PubMed:8637595). Taurus_UMD|evm.model.AC_000164.1.996 O14776 TCRG1_HUMAN 93.443 0.998081 0.948998 TCERG1 - Transcription elongation regulator 1 - Homo sapiens (Human) - TCERG1 gene Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. Taurus_UMD|evm.model.AC_000164.1.997 Q8TDV0 GP151_HUMAN 85.961 0.995086 0.97136 GPR151 - G-protein coupled receptor 151 - Homo sapiens (Human) - GPR151 gene Proton-sensing G-protein coupled receptor. Taurus_UMD|evm.model.AC_000164.1.998 Q5R4A2 2ABB_PONAB 100.000 0.866667 1.15124 PPP2R2B - Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform - Pongo abelii (Sumatran orangutan) - PPP2R2B gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Taurus_UMD|evm.model.AC_000164.1.999 Q8BGW6 ST32A_MOUSE 91.457 0.994962 0.997487 Stk32a - Serine/threonine-protein kinase 32A - Mus musculus (Mouse) - Stk32a gene protein serine/threonine kinase activity, intracellular signal transduction, peptidyl-serine phosphorylation Taurus_UMD|evm.model.AC_000164.1.1001 Q14195 DPYL3_HUMAN 98.246 0.996497 1.00175 DPYSL3 - Dihydropyrimidinase-related protein 3 - Homo sapiens (Human) - DPYSL3 gene Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). Taurus_UMD|evm.model.AC_000164.1.1003 Q96AA8 JKIP2_HUMAN 99.751 0.978076 1.01358 JAKMIP2 - Janus kinase and microtubule-interacting protein 2 - Homo sapiens (Human) - JAKMIP2 gene Golgi apparatus Taurus_UMD|evm.model.AC_000164.1.1004 Q96PL1 SG3A2_HUMAN 79.310 0.897727 0.946237 SCGB3A2 - Secretoglobin family 3A member 2 precursor - Homo sapiens (Human) - SCGB3A2 gene Secreted cytokine-like protein (PubMed:12847263). Binds to the scavenger receptor MARCO (PubMed:12847263). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (PubMed:12847263). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed:24213919). Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung (PubMed:24213919). May play a role in fetal lung development and maturation (PubMed:24213919). Promotes branching morphogenesis during early stages of lung development (PubMed:24213919). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (By similarity). Taurus_UMD|evm.model.AC_000164.1.1005 Q3T146 CE046_BOVIN 100.000 0.977528 1.01136 Uncharacterized protein C5orf46 homolog precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000164.1.1006 Q9NQ38 ISK5_HUMAN 63.219 0.99359 1.02632 SPINK5 - Serine protease inhibitor Kazal-type 5 precursor - Homo sapiens (Human) - SPINK5 gene Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. Taurus_UMD|evm.model.AC_000164.1.1007 P08480 IPSG_FELCA 66.667 0.737931 1.30631 Double-headed protease inhibitor, submandibular gland - Felis catus (Cat) Taurus_UMD|evm.model.AC_000164.1.1010 Q5DT21 ISK9_HUMAN 58.442 0.770833 1.11628 SPINK9 - Serine protease inhibitor Kazal-type 9 precursor - Homo sapiens (Human) - SPINK9 gene Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5. Taurus_UMD|evm.model.AC_000164.1.1011 Q6PIJ6 FBX38_HUMAN 97.811 0.998318 1.00084 FBXO38 - F-box only protein 38 - Homo sapiens (Human) - FBXO38 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). Taurus_UMD|evm.model.AC_000164.1.1012 O70528 5HT4R_CAVPO 92.350 0.99455 0.945876 HTR4 - 5-hydroxytryptamine receptor 4 - Cavia porcellus (Guinea pig) - HTR4 gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (By similarity). Taurus_UMD|evm.model.AC_000164.1.1013 Q28044 ADRB2_BOVIN 100.000 0.995227 1.00239 ADRB2 - Beta-2 adrenergic receptor - Bos taurus (Bovine) - ADRB2 gene Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity). Taurus_UMD|evm.model.AC_000164.1.1014 Q8TF17 S3TC2_HUMAN 87.587 0.99845 1.00155 SH3TC2 - SH3 domain and tetratricopeptide repeat-containing protein 2 - Homo sapiens (Human) - SH3TC2 gene Taurus_UMD|evm.model.AC_000164.1.1015 O94929 ABLM3_HUMAN 83.748 0.996785 0.910688 ABLIM3 - Actin-binding LIM protein 3 - Homo sapiens (Human) - ABLIM3 gene May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. Taurus_UMD|evm.model.AC_000164.1.1016 A6QQV9 AF1L1_BOVIN 100.000 0.997382 1.00131 AFAP1L1 - Actin filament-associated protein 1-like 1 - Bos taurus (Bovine) - AFAP1L1 gene May be involved in podosome and invadosome formation. Taurus_UMD|evm.model.AC_000164.1.1017 Q0P5N5 GRPE2_BOVIN 100.000 0.991111 1.00446 GRPEL2 - GrpE protein homolog 2, mitochondrial precursor - Bos taurus (Bovine) - GRPEL2 gene Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). Taurus_UMD|evm.model.AC_000164.1.1018 Q0P5H1 PCYXL_BOVIN 100.000 0.995943 1.00203 PCYOX1L - Prenylcysteine oxidase-like precursor - Bos taurus (Bovine) - PCYOX1L gene Probable oxidoreductase. Taurus_UMD|evm.model.AC_000164.1.1019 Q9UHF5 IL17B_HUMAN 91.667 0.98895 1.00556 IL17B - Interleukin-17B precursor - Homo sapiens (Human) - IL17B gene Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. Taurus_UMD|evm.model.AC_000164.1.1021 Q8BK63 KC1A_MOUSE 100.000 0.994083 1.00297 Csnk1a1 - Casein kinase I isoform alpha - Mus musculus (Mouse) - Csnk1a1 gene Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (By similarity). Taurus_UMD|evm.model.AC_000164.1.1022 A1IGU5 ARH37_HUMAN 85.926 0.997037 1 ARHGEF37 - Rho guanine nucleotide exchange factor 37 - Homo sapiens (Human) - ARHGEF37 gene May act as a guanine nucleotide exchange factor (GEF). Taurus_UMD|evm.model.AC_000164.1.1023 Q86YN6 PRGC2_HUMAN 80.414 0.998095 1.02639 PPARGC1B - Peroxisome proliferator-activated receptor gamma coactivator 1-beta - Homo sapiens (Human) - PPARGC1B gene Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Taurus_UMD|evm.model.AC_000164.1.1024 P11541 PDE6A_BOVIN 96.659 0.985472 0.961583 PDE6A - Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha precursor - Bos taurus (Bovine) - PDE6A gene This protein participates in processes of transmission and amplification of the visual signal. Taurus_UMD|evm.model.AC_000164.1.1025 Q9BEG8 S26A2_BOVIN 99.864 0.997279 1.00136 SLC26A2 - Sulfate transporter - Bos taurus (Bovine) - SLC26A2 gene Sulfate transporter. May play a role in endochondral bone formation. Taurus_UMD|evm.model.AC_000164.1.1026 Q17RP2 TIGD6_HUMAN 74.809 0.714286 0.349328 TIGD6 - Tigger transposable element-derived protein 6 - Homo sapiens (Human) - TIGD6 gene nucleus, DNA binding Taurus_UMD|evm.model.AC_000164.1.1029 Q12766 HMGX3_HUMAN 92.549 0.98526 0.838101 HMGXB3 - HMG domain-containing protein 3 - Homo sapiens (Human) - HMGXB3 gene Taurus_UMD|evm.model.AC_000164.1.1030 P00545 KFMS_FSVMD 83.640 0.95544 0.986708 V-FMS - Tyrosine-protein kinase transforming protein fms - Feline sarcoma virus (strain McDonough) - V-FMS gene Truncated version of the receptor for colony-stimulating factor 1 (CSF-1). Taurus_UMD|evm.model.AC_000164.1.1031 A2T7H5 CDX1_PONPY 87.681 0.643192 0.803774 CDX1 - Homeobox protein CDX-1 - Pongo pygmaeus (Bornean orangutan) - CDX1 gene Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA. Taurus_UMD|evm.model.AC_000164.1.1032 Q99626 CDX2_HUMAN 91.304 0.419753 0.517572 CDX2 - Homeobox protein CDX-2 - Homo sapiens (Human) - CDX2 gene Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536). Taurus_UMD|evm.model.AC_000164.1.1033 Q6QNF3 PGFRB_CANLF 92.935 0.998188 1.00091 PDGFRB - Platelet-derived growth factor receptor beta precursor - Canis lupus familiaris (Dog) - PDGFRB gene Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor (By similarity). Taurus_UMD|evm.model.AC_000164.1.1034 Q99884 SC6A7_HUMAN 98.428 0.74356 1.34277 SLC6A7 - Sodium-dependent proline transporter - Homo sapiens (Human) - SLC6A7 gene Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals. Taurus_UMD|evm.model.AC_000164.1.1035 P11275 KCC2A_RAT 97.751 0.995918 1.0251 Camk2a - Calcium/calmodulin-dependent protein kinase type II subunit alpha - Rattus norvegicus (Rat) - Camk2a gene Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). Taurus_UMD|evm.model.AC_000164.1.1036 Q32KH7 ARSI_CANLF 96.161 0.993043 1.00349 ARSI - Arylsulfatase I precursor - Canis lupus familiaris (Dog) - ARSI gene Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. Taurus_UMD|evm.model.AC_000164.1.1037 Q13428 TCOF_HUMAN 57.450 0.962303 0.980511 TCOF1 - Treacle protein - Homo sapiens (Human) - TCOF1 gene Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Taurus_UMD|evm.model.AC_000164.1.1038 P04233 HG2A_HUMAN 81.111 0.992565 0.908784 CD74 - HLA class II histocompatibility antigen gamma chain - Homo sapiens (Human) - CD74 gene Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Taurus_UMD|evm.model.AC_000164.1.1039 P62264 RS14_MOUSE 100.000 0.925926 1.07285 Rps14 - 40S ribosomal protein S14 - Mus musculus (Mouse) - Rps14 gene cytosol, cytosolic small ribosomal subunit, mitochondrion, nucleolus, postsynaptic density, mRNA 5'-UTR binding, RNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome, translation regulator activity Taurus_UMD|evm.model.AC_000164.1.1040 P52848 NDST1_HUMAN 98.186 0.997735 1.00113 NDST1 - Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 - Homo sapiens (Human) - NDST1 gene Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (PubMed:10758005, PubMed:12634318). Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (PubMed:10758005, PubMed:12634318). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Taurus_UMD|evm.model.AC_000164.1.1041 Q8N3V7 SYNPO_HUMAN 83.921 0.800178 1.21206 SYNPO - Synaptopodin - Homo sapiens (Human) - SYNPO gene Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). Taurus_UMD|evm.model.AC_000164.1.1042 Q8TDC0 MYOZ3_HUMAN 78.884 0.99187 0.98008 MYOZ3 - Myozenin-3 - Homo sapiens (Human) - MYOZ3 gene Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. Taurus_UMD|evm.model.AC_000164.1.1043 Q8BHS3 RBM22_MOUSE 100.000 0.995249 1.00238 Rbm22 - Pre-mRNA-splicing factor RBM22 - Mus musculus (Mouse) - Rbm22 gene Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. Taurus_UMD|evm.model.AC_000164.1.1044 Q9UJW0 DCTN4_HUMAN 98.043 0.995662 1.00217 DCTN4 - Dynactin subunit 4 - Homo sapiens (Human) - DCTN4 gene Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. Taurus_UMD|evm.model.AC_000164.1.1045 Q9BZL3 SMIM3_HUMAN 91.667 0.694118 1.41667 SMIM3 - Small integral membrane protein 3 - Homo sapiens (Human) - SMIM3 gene identical protein binding Taurus_UMD|evm.model.AC_000164.1.1046 Q96RE9 ZN300_HUMAN 84.743 0.846262 1.17384 ZNF300 - Zinc finger protein 300 - Homo sapiens (Human) - ZNF300 gene Has a transcriptional repressor activity. Taurus_UMD|evm.model.AC_000164.1.1047 P37141 GPX3_BOVIN 95.595 0.99115 1 GPX3 - Glutathione peroxidase 3 precursor - Bos taurus (Bovine) - GPX3 gene Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. Taurus_UMD|evm.model.AC_000164.1.1048 Q15025 TNIP1_HUMAN 87.284 0.996845 0.996855 TNIP1 - TNFAIP3-interacting protein 1 - Homo sapiens (Human) - TNIP1 gene Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. Taurus_UMD|evm.model.AC_000164.1.1049 P79134 ANXA6_BOVIN 100.000 0.910569 1.09658 ANXA6 - Annexin A6 - Bos taurus (Bovine) - ANXA6 gene May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. Taurus_UMD|evm.model.AC_000164.1.1050 A6QNP9 CCD69_BOVIN 99.660 0.99322 1.0034 CCDC69 - Coiled-coil domain-containing protein 69 - Bos taurus (Bovine) - CCDC69 gene May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone. Taurus_UMD|evm.model.AC_000164.1.1051 P17900 SAP3_HUMAN 68.293 0.840206 1.00518 GM2A - Ganglioside GM2 activator precursor - Homo sapiens (Human) - GM2A gene The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 (By similarity). Has cholesterol transfer activity (PubMed:17552909). Taurus_UMD|evm.model.AC_000164.1.1052 Q495N2 S36A3_HUMAN 82.172 0.989837 1.04681 SLC36A3 - Proton-coupled amino acid transporter 3 - Homo sapiens (Human) - SLC36A3 gene amino acid transmembrane transporter activity, amino acid:proton symporter activity, glycine transmembrane transporter activity, L-alanine transmembrane transporter activity, L-proline transmembrane transporter activity, amino acid transmembrane transport, glycine transport, L-alanine transport, proline transmembrane transport, proton transmembrane transport Taurus_UMD|evm.model.AC_000164.1.1053 Q495M3 S36A2_HUMAN 80.538 0.995859 1 SLC36A2 - Proton-coupled amino acid transporter 2 - Homo sapiens (Human) - SLC36A2 gene Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity). Taurus_UMD|evm.model.AC_000164.1.1055 Q7Z2H8 S36A1_HUMAN 89.286 0.935039 1.06723 SLC36A1 - Proton-coupled amino acid transporter 1 - Homo sapiens (Human) - SLC36A1 gene Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognizes their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity). Taurus_UMD|evm.model.AC_000164.1.1057 Q9NYQ8 FAT2_HUMAN 86.741 0.994021 0.730743 FAT2 - Protocadherin Fat 2 precursor - Homo sapiens (Human) - FAT2 gene Involved in the regulation of cell migration (PubMed:18534823). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity). Taurus_UMD|evm.model.AC_000164.1.1058 Q9NYQ8 FAT2_HUMAN 87.332 0.991646 0.275236 FAT2 - Protocadherin Fat 2 precursor - Homo sapiens (Human) - FAT2 gene Involved in the regulation of cell migration (PubMed:18534823). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity). Taurus_UMD|evm.model.AC_000164.1.1059 P13213 SPRC_BOVIN 100.000 0.993421 1.0033 SPARC - SPARC precursor - Bos taurus (Bovine) - SPARC gene Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. Taurus_UMD|evm.model.AC_000164.1.1060 Q9XT28 ATOX1_SHEEP 97.059 0.957143 1.02941 ATOX1 - Copper transport protein ATOX1 - Ovis aries (Sheep) - ATOX1 gene Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity). Taurus_UMD|evm.model.AC_000164.1.1061 Q32LC7 G3BP1_BOVIN 100.000 0.926148 1.07742 G3BP1 - Ras GTPase-activating protein-binding protein 1 - Bos taurus (Bovine) - G3BP1 gene ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. Taurus_UMD|evm.model.AC_000164.1.1062 P57695 GLRA1_BOVIN 98.881 0.950644 1.01969 GLRA1 - Glycine receptor subunit alpha-1 precursor - Bos taurus (Bovine) - GLRA1 gene Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (By similarity). Plays an important role in the down-regulation of neuronal excitability (PubMed:11178872). Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity). Taurus_UMD|evm.model.AC_000164.1.1063 Q58CW4 NMUR2_BOVIN 100.000 0.995098 1.00246 NMUR2 - Neuromedin-U receptor 2 - Bos taurus (Bovine) - NMUR2 gene Receptor for the neuromedin-U and neuromedin-S neuropeptides. Taurus_UMD|evm.model.AC_000164.1.1065 P24049 RL17_RAT 75.000 0.697842 0.755435 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000164.1.1066 Q38PU8 GRIA1_MACFA 99.669 0.997795 1.0011 GRIA1 - Glutamate receptor 1 precursor - Macaca fascicularis (Crab-eating macaque) - GRIA1 gene Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). Taurus_UMD|evm.model.AC_000164.1.1067 Q2T9N1 F1142_BOVIN 99.800 0.996008 1.002 FAM114A1 - Protein FAM114A2 - Bos taurus (Bovine) - FAM114A1 gene Taurus_UMD|evm.model.AC_000164.1.1068 Q28103 MFAP3_BOVIN 99.429 0.479339 2.07429 MFAP3 - Microfibril-associated glycoprotein 3 - Bos taurus (Bovine) - MFAP3 gene Component of the elastin-associated microfibrils. Taurus_UMD|evm.model.AC_000164.1.1069 Q86SR1 GLT10_HUMAN 95.455 0.99637 0.913765 GALNT10 - Polypeptide N-acetylgalactosaminyltransferase 10 - Homo sapiens (Human) - GALNT10 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates. Taurus_UMD|evm.model.AC_000164.1.1070 Q0VCE2 HAND1_BOVIN 100.000 0.989744 0.894495 HAND1 - Heart- and neural crest derivatives-expressed protein 1 - Bos taurus (Bovine) - HAND1 gene Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity). Taurus_UMD|evm.model.AC_000164.1.1071 Q9HAJ7 SP30L_HUMAN 98.907 0.989071 1 SAP30L - Histone deacetylase complex subunit SAP30L - Homo sapiens (Human) - SAP30L gene Functions as transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676). Taurus_UMD|evm.model.AC_000164.1.1072 O46415 FRIL_BOVIN 96.203 0.975 0.457143 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000164.1.1073 Q6PKG0 LARP1_HUMAN 96.013 0.995807 0.870438 LARP1 - La-related protein 1 - Homo sapiens (Human) - LARP1 gene RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:26206669, PubMed:28379136). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:28379136). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). Taurus_UMD|evm.model.AC_000164.1.1075 Q96IV6 FXDC2_HUMAN 66.364 0.454167 0.720721 FAXDC2 - Fatty acid hydroxylase domain-containing protein 2 - Homo sapiens (Human) - FAXDC2 gene Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression. Taurus_UMD|evm.model.AC_000164.1.1076 Q9UFF9 CNOT8_HUMAN 100.000 0.993174 1.00342 CNOT8 - CCR4-NOT transcription complex subunit 8 - Homo sapiens (Human) - CNOT8 gene Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. Taurus_UMD|evm.model.AC_000164.1.1077 Q8TEQ6 GEMI5_HUMAN 85.553 0.997969 0.979443 GEMIN5 - Gem-associated protein 5 - Homo sapiens (Human) - GEMIN5 gene Required for the assembly of the SMN complex that plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:16857593, PubMed:18984161, PubMed:20513430). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:18984161). GEMIN5 acts as the snRNA-binding protein of the SMN complex (PubMed:11714716, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.25). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). Taurus_UMD|evm.model.AC_000164.1.1078 Q3SZX5 RM22_BOVIN 97.143 0.990521 1.03431 MRPL22 - 39S ribosomal protein L22, mitochondrial precursor - Bos taurus (Bovine) - MRPL22 gene large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, structural constituent of ribosome, ribosome assembly Taurus_UMD|evm.model.AC_000164.1.1079 Q56JY1 RL35A_BOVIN 86.316 0.930693 0.918182 RPL35A - 60S ribosomal protein L35a - Bos taurus (Bovine) - RPL35A gene Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation (By similarity). The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site (By similarity). Taurus_UMD|evm.model.AC_000164.1.1080 P70081 H48_CHICK 88.732 0.786517 0.864078 H4-VIII - Histone H4 type VIII - Gallus gallus (Chicken) - H4-VIII gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000164.1.1081 Q92629 SGCD_HUMAN 97.924 0.993103 1.00346 SGCD - Delta-sarcoglycan - Homo sapiens (Human) - SGCD gene Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Taurus_UMD|evm.model.AC_000164.1.1082 Q5FVR0 TIMD2_RAT 51.327 0.818182 0.378223 Timd2 - T-cell immunoglobulin and mucin domain-containing protein 2 precursor - Rattus norvegicus (Rat) - Timd2 gene Probable receptor for SEMA4A involved in the regulation of T-cell function. The interaction with SEMA4A enhances T-cell activation (By similarity). Taurus_UMD|evm.model.AC_000164.1.1083 Q96H15 TIMD4_HUMAN 54.856 0.994135 0.902116 TIMD4 - T-cell immunoglobulin and mucin domain-containing protein 4 precursor - Homo sapiens (Human) - TIMD4 gene Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity). Taurus_UMD|evm.model.AC_000164.1.1085 P58365 CAD23_RAT 94.393 0.439834 0.072656 Cdh23 - Cadherin-23 precursor - Rattus norvegicus (Rat) - Cdh23 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Taurus_UMD|evm.model.AC_000164.1.1086 Q5QNS5 HAVR1_MOUSE 51.639 0.248936 1.54098 Havcr1 - Hepatitis A virus cellular receptor 1 homolog precursor - Mus musculus (Mouse) - Havcr1 gene May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair (By similarity). Taurus_UMD|evm.model.AC_000164.1.1087 Q96H15 TIMD4_HUMAN 44.318 0.47027 0.489418 TIMD4 - T-cell immunoglobulin and mucin domain-containing protein 4 precursor - Homo sapiens (Human) - TIMD4 gene Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity). Taurus_UMD|evm.model.AC_000164.1.1088 Q96D42 HAVR1_HUMAN 62.366 0.162257 1.55769 HAVCR1 - Hepatitis A virus cellular receptor 1 precursor - Homo sapiens (Human) - HAVCR1 gene May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair. Taurus_UMD|evm.model.AC_000164.1.1089 P70206 PLXA1_MOUSE 65.625 0.969072 0.0512144 Plxna1 - Plexin-A1 precursor - Mus musculus (Mouse) - Plxna1 gene Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Taurus_UMD|evm.model.AC_000164.1.1090 Q8TDQ0 HAVR2_HUMAN 66.207 0.989324 0.933555 HAVCR2 - Hepatitis A virus cellular receptor 2 precursor - Homo sapiens (Human) - HAVCR2 gene Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857). Receptor for LGALS9 (PubMed:16286920, PubMed:24337741). Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged (PubMed:23555261). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453). In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801). Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity). Taurus_UMD|evm.model.AC_000164.1.1091 Q3T123 MED7_BOVIN 99.571 0.991453 1.00429 MED7 - Mediator of RNA polymerase II transcription subunit 7 - Bos taurus (Bovine) - MED7 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Taurus_UMD|evm.model.AC_000164.1.1092 Q66H38 FA71B_RAT 79.661 0.39966 0.90881 Fam71b - Protein FAM71B - Rattus norvegicus (Rat) - Fam71b gene May be involved in RNA biogenesis. Taurus_UMD|evm.model.AC_000164.1.1093 Q08881 ITK_HUMAN 90.161 0.996587 0.945161 ITK - Tyrosine-protein kinase ITK/TSK - Homo sapiens (Human) - ITK gene Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). Taurus_UMD|evm.model.AC_000164.1.1095 Q96F07 CYFP2_HUMAN 89.593 0.998304 0.922535 CYFIP2 - Cytoplasmic FMR1-interacting protein 2 - Homo sapiens (Human) - CYFIP2 gene Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Taurus_UMD|evm.model.AC_000164.1.1096 Q0D2K0 NIPA4_HUMAN 86.881 0.995062 0.869099 NIPAL4 - Magnesium transporter NIPA4 - Homo sapiens (Human) - NIPAL4 gene Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway. Taurus_UMD|evm.model.AC_000164.1.1098 Q9H013 ADA19_HUMAN 81.728 0.978996 0.897382 ADAM19 - Disintegrin and metalloproteinase domain-containing protein 19 precursor - Homo sapiens (Human) - ADAM19 gene Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). Taurus_UMD|evm.model.AC_000164.1.1099 Q8CGW4 SOX30_MOUSE 83.594 0.830508 0.980818 Sox30 - Transcription factor SOX-30 - Mus musculus (Mouse) - Sox30 gene Acts as both a transcriptional activator and repressor (PubMed:29866902, PubMed:29848638). Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (PubMed:29866902). Binds to its own promoter and activates its own transcription (PubMed:29866902, PubMed:29848638). Required to activate the expression of postmeiotic genes involved in spermiogenesis (PubMed:29866902, PubMed:29848638). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (By similarity). Taurus_UMD|evm.model.AC_000164.1.1100 Q05B50 THG1_BOVIN 100.000 0.993311 1.00336 THG1L - Probable tRNA(His) guanylyltransferase - Bos taurus (Bovine) - THG1L gene Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress. Taurus_UMD|evm.model.AC_000164.1.1101 P83369 LSM11_HUMAN 87.500 0.994203 0.958333 LSM11 - U7 snRNA-associated Sm-like protein LSm11 - Homo sapiens (Human) - LSM11 gene Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA. Taurus_UMD|evm.model.AC_000164.1.1102 A7Z035 EPN4_BOVIN 100.000 0.996894 1.00156 CLINT1 - Clathrin interactor 1 - Bos taurus (Bovine) - CLINT1 gene Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (By similarity). Taurus_UMD|evm.model.AC_000164.1.1103 P45973 CBX5_HUMAN 81.579 0.266187 0.727749 CBX5 - Chromobox protein homolog 5 - Homo sapiens (Human) - CBX5 gene Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Taurus_UMD|evm.model.AC_000164.1.1104 O77689 CCNB2_BOVIN 86.475 0.727545 0.839196 CCNB2 - G2/mitotic-specific cyclin-B2 - Bos taurus (Bovine) - CCNB2 gene Essential for the control of the cell cycle at the G2/M (mitosis) transition. Taurus_UMD|evm.model.AC_000164.1.1107 Q07802 COE1_MOUSE 99.492 0.996622 1.00169 Ebf1 - Transcription factor COE1 - Mus musculus (Mouse) - Ebf1 gene Key pioneer transcription factor of B-cell specification and commitment (PubMed:1915300, PubMed:7542362, PubMed:23812095). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (PubMed:20876732). Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates (PubMed:23812095, PubMed:20451411). For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage (PubMed:23812095, PubMed:20451411). In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (PubMed:32130892). Taurus_UMD|evm.model.AC_000164.1.1108 Q96MT1 RN145_HUMAN 90.272 0.984463 1.06787 RNF145 - RING finger protein 145 - Homo sapiens (Human) - RNF145 gene E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'-linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function. In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately downregulating cholesterol biosynthesis. Taurus_UMD|evm.model.AC_000164.1.1109 Q8WVY7 UBCP1_HUMAN 100.000 0.99373 1.00314 UBLCP1 - Ubiquitin-like domain-containing CTD phosphatase 1 - Homo sapiens (Human) - UBLCP1 gene Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome. Taurus_UMD|evm.model.AC_000164.1.1110 P46282 IL12B_BOVIN 100.000 0.993902 1.00306 IL12B - Interleukin-12 subunit beta precursor - Bos taurus (Bovine) - IL12B gene Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Taurus_UMD|evm.model.AC_000164.1.1111 P35368 ADA1B_HUMAN 96.923 0.996124 0.992308 ADRA1B - Alpha-1B adrenergic receptor - Homo sapiens (Human) - ADRA1B gene This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. Taurus_UMD|evm.model.AC_000164.1.1112 Q3ZBR5 TTC1_BOVIN 100.000 0.993174 1.00342 TTC1 - Tetratricopeptide repeat protein 1 - Bos taurus (Bovine) - TTC1 gene Taurus_UMD|evm.model.AC_000164.1.1113 Q96N64 PWP2A_HUMAN 91.667 0.991919 0.655629 PWWP2A - PWWP domain-containing protein 2A - Homo sapiens (Human) - PWWP2A gene H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. Also required for proper mitosis progression. Taurus_UMD|evm.model.AC_000164.1.1114 Q3T0Z2 FABP6_BOVIN 100.000 0.984496 1.00781 FABP6 - Gastrotropin - Bos taurus (Bovine) - FABP6 gene Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. Stimulates gastric acid and pepsinogen secretion (By similarity). Taurus_UMD|evm.model.AC_000164.1.1115 Q5SRT8 CCNJL_MOUSE 88.114 0.989664 1 Ccnjl - Cyclin-J-like protein - Mus musculus (Mouse) - Ccnjl gene centrosome, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus, cyclin-dependent protein serine/threonine kinase regulator activity, mitotic cell cycle phase transition, regulation of cyclin-dependent protein serine/threonine kinase activity Taurus_UMD|evm.model.AC_000164.1.1116 Q9BXJ5 C1QT2_HUMAN 94.035 0.993007 1.00351 C1QTNF2 - Complement C1q tumor necrosis factor-related protein 2 precursor - Homo sapiens (Human) - C1QTNF2 gene Involved in the regulation of lipid metabolism in adipose tissue and liver. Taurus_UMD|evm.model.AC_000164.1.1117 A4Z945 ZBED8_BOVIN 100.000 0.996639 1.00168 ZBED8 - Protein ZBED8 - Bos taurus (Bovine) - ZBED8 gene Taurus_UMD|evm.model.AC_000164.1.1118 Q3ZBE5 SLU7_BOVIN 100.000 0.996593 1.00171 SLU7 - Pre-mRNA-splicing factor SLU7 - Bos taurus (Bovine) - SLU7 gene Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Taurus_UMD|evm.model.AC_000164.1.1119 Q3SZY3 PTTG1_BOVIN 100.000 0.990148 1.00495 PTTG1 - Securin - Bos taurus (Bovine) - PTTG1 gene Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity). Taurus_UMD|evm.model.AC_000164.1.1120 O94823 AT10B_HUMAN 80.255 0.103931 1.02738 ATP10B - Phospholipid-transporting ATPase VB - Homo sapiens (Human) - ATP10B gene Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. Taurus_UMD|evm.model.AC_000164.1.1121 Q9H2H8 PPIL3_HUMAN 93.069 0.884956 0.701863 PPIL3 - Peptidyl-prolyl cis-trans isomerase-like 3 - Homo sapiens (Human) - PPIL3 gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000164.1.1122 Q5R893 H2B1_PONAB 88.095 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000164.1.1123 P63138 GBRB2_RAT 99.757 0.995146 0.869198 Gabrb2 - Gamma-aminobutyric acid receptor subunit beta-2 precursor - Rattus norvegicus (Rat) - Gabrb2 gene Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2548852). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). Taurus_UMD|evm.model.AC_000164.1.1124 Q16445 GBRA6_HUMAN 94.923 0.995595 1.00221 GABRA6 - Gamma-aminobutyric acid receptor subunit alpha-6 precursor - Homo sapiens (Human) - GABRA6 gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Taurus_UMD|evm.model.AC_000164.1.1126 P08219 GBRA1_BOVIN 100.000 0.995624 1.00219 GABRA1 - Gamma-aminobutyric acid receptor subunit alpha-1 precursor - Bos taurus (Bovine) - GABRA1 gene Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:3037384). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (By similarity). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Taurus_UMD|evm.model.AC_000164.1.1127 Q10126 YSM6_CAEEL 30.000 0.47651 1.0681 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000164.1.1128 P18508 GBRG2_RAT 99.326 0.995516 0.957082 Gabrg2 - Gamma-aminobutyric acid receptor subunit gamma-2 precursor - Rattus norvegicus (Rat) - Gabrg2 gene Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2561970). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor, alpha2/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Taurus_UMD|evm.model.AC_000164.1.1129 O75330 HMMR_HUMAN 85.882 0.617647 0.187845 HMMR - Hyaluronan mediated motility receptor - Homo sapiens (Human) - HMMR gene Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). Taurus_UMD|evm.model.AC_000164.1.1130 O75330 HMMR_HUMAN 76.744 0.807692 0.0718232 HMMR - Hyaluronan mediated motility receptor - Homo sapiens (Human) - HMMR gene Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). Taurus_UMD|evm.model.AC_000164.1.1132 Q13813 SPTN1_HUMAN 99.153 0.89313 0.0529935 SPTAN1 - Spectrin alpha chain, non-erythrocytic 1 - Homo sapiens (Human) - SPTAN1 gene Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Taurus_UMD|evm.model.AC_000164.1.1133 Q5E9I1 CCNG1_BOVIN 100.000 0.993243 1.00339 CCNG1 - Cyclin-G1 - Bos taurus (Bovine) - CCNG1 gene May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). Taurus_UMD|evm.model.AC_000164.1.1134 Q9CQ48 NUDC2_MOUSE 99.363 0.987342 1.00637 Nudcd2 - NudC domain-containing protein 2 - Mus musculus (Mouse) - Nudcd2 gene May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. Taurus_UMD|evm.model.AC_000164.1.1135 O75330 HMMR_HUMAN 83.613 0.99581 0.98895 HMMR - Hyaluronan mediated motility receptor - Homo sapiens (Human) - HMMR gene Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). Taurus_UMD|evm.model.AC_000164.1.1136 Q29RI9 MAT2B_BOVIN 100.000 0.99403 1.00299 MAT2B - Methionine adenosyltransferase 2 subunit beta - Bos taurus (Bovine) - MAT2B gene Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro). Taurus_UMD|evm.model.AC_000164.1.1139 P21329 RTJK_DROFU 29.143 0.95 0.196507 jockey\pol - RNA-directed DNA polymerase from mobile element jockey - Drosophila funebris (Fruit fly) - jockey\pol gene Taurus_UMD|evm.model.AC_000164.1.1140 Q13796 SHRM2_HUMAN 55.319 0.547619 0.0519802 SHROOM2 - Protein Shroom2 - Homo sapiens (Human) - SHROOM2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). Taurus_UMD|evm.model.AC_000164.1.1141 Q13796 SHRM2_HUMAN 65.934 0.75 0.0717822 SHROOM2 - Protein Shroom2 - Homo sapiens (Human) - SHROOM2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). Taurus_UMD|evm.model.AC_000164.1.1142 Q6GQS1 SCMC3_MOUSE 45.614 0.968085 0.40257 Slc25a23 - Calcium-binding mitochondrial carrier protein SCaMC-3 - Mus musculus (Mouse) - Slc25a23 gene Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. Acts as a regulator of mitochondrial calcium uptake via interaction with MCU and MICU1. Taurus_UMD|evm.model.AC_000164.1.1144 P63219 GBG5_RAT 96.825 0.984127 0.926471 Gng5 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 precursor - Rattus norvegicus (Rat) - Gng5 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Taurus_UMD|evm.model.AC_000164.1.1146 Q2NKR3 COXM2_BOVIN 100.000 0.965517 0.734177 CMC2 - COX assembly mitochondrial protein 2 homolog - Bos taurus (Bovine) - CMC2 gene May be involved in cytochrome c oxidase biogenesis. Taurus_UMD|evm.model.AC_000164.1.1147 Q9NT68 TEN2_HUMAN 98.684 0.657895 0.0410959 TENM2 - Teneurin-2 - Homo sapiens (Human) - TENM2 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer. Taurus_UMD|evm.model.AC_000164.1.1150 Q9WTS5 TEN2_MOUSE 100.000 0.866667 0.0325615 Tenm2 - Teneurin-2 - Mus musculus (Mouse) - Tenm2 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a ligand of the ADGRL1 receptor. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer (By similarity). Taurus_UMD|evm.model.AC_000164.1.1151 Q9WTS5 TEN2_MOUSE 82.243 0.619048 0.0607815 Tenm2 - Teneurin-2 - Mus musculus (Mouse) - Tenm2 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a ligand of the ADGRL1 receptor. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer (By similarity). Taurus_UMD|evm.model.AC_000164.1.1152 Q9NT68 TEN2_HUMAN 75.579 0.973382 0.785508 TENM2 - Teneurin-2 - Homo sapiens (Human) - TENM2 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer. Taurus_UMD|evm.model.AC_000164.1.1153 Q8IX03 KIBRA_HUMAN 94.070 0.998193 0.994609 WWC1 - Protein KIBRA - Homo sapiens (Human) - WWC1 gene Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance. Taurus_UMD|evm.model.AC_000164.1.1154 A7YW98 SYRC_BOVIN 100.000 0.996974 1.00152 RARS1 - Arginine--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - RARS1 gene Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1. Taurus_UMD|evm.model.AC_000164.1.1155 A6NHQ2 FBLL1_HUMAN 96.813 0.755287 0.991018 FBLL1 - rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 - Homo sapiens (Human) - FBLL1 gene S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity). Taurus_UMD|evm.model.AC_000164.1.1156 Q6UXP7 F151B_HUMAN 89.925 0.149162 6.48551 FAM151B - Protein FAM151B - Homo sapiens (Human) - FAM151B gene Taurus_UMD|evm.model.AC_000164.1.1157 A5PLL1 AN34B_HUMAN 89.105 0.996101 0.998054 ANKRD34B - Ankyrin repeat domain-containing protein 34B - Homo sapiens (Human) - ANKRD34B gene Taurus_UMD|evm.model.AC_000164.1.1158 P00376 DYR_BOVIN 99.231 0.969925 0.71123 DHFR - Dihydrofolate reductase - Bos taurus (Bovine) - DHFR gene Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2 (By similarity). Taurus_UMD|evm.model.AC_000164.1.1159 P20585 MSH3_HUMAN 85.216 0.570565 0.872471 MSH3 - DNA mismatch repair protein Msh3 - Homo sapiens (Human) - MSH3 gene Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Taurus_UMD|evm.model.AC_000164.1.1160 O14827 RGRF2_HUMAN 96.772 0.998387 1.00243 RASGRF2 - Ras-specific guanine nucleotide-releasing factor 2 - Homo sapiens (Human) - RASGRF2 gene Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. Taurus_UMD|evm.model.AC_000164.1.1161 Q3ZBP1 KCRS_BOVIN 99.761 0.995238 1.00239 CKMT2 - Creatine kinase S-type, mitochondrial precursor - Bos taurus (Bovine) - CKMT2 gene Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). Taurus_UMD|evm.model.AC_000164.1.1162 Q8N567 ZCHC9_HUMAN 92.620 0.992647 1.00369 ZCCHC9 - Zinc finger CCHC domain-containing protein 9 - Homo sapiens (Human) - ZCCHC9 gene May down-regulate transcription mediated by NF-kappa-B and the serum response element. Taurus_UMD|evm.model.AC_000164.1.1163 Q8WYK0 ACO12_HUMAN 86.486 0.992832 1.00541 ACOT12 - Acetyl-coenzyme A thioesterase - Homo sapiens (Human) - ACOT12 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16951743). Acyl-coenzyme A thioesterase 12/ACOT12 preferentially hydrolyzes acetyl-CoA (PubMed:16951743). Taurus_UMD|evm.model.AC_000164.1.1164 P81877 SSBP2_HUMAN 100.000 0.994475 1.00277 SSBP2 - Single-stranded DNA-binding protein 2 - Homo sapiens (Human) - SSBP2 gene cytoplasm, nucleus, single-stranded DNA binding, positive regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated Taurus_UMD|evm.model.AC_000164.1.1165 Q9H0Y0 ATG10_HUMAN 87.919 0.72549 0.927273 ATG10 - Ubiquitin-like-conjugating enzyme ATG10 - Homo sapiens (Human) - ATG10 gene E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis. Taurus_UMD|evm.model.AC_000164.1.1166 P62268 RS23_RAT 100.000 0.986111 1.00699 Rps23 - 40S ribosomal protein S23 - Rattus norvegicus (Rat) - Rps23 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy. Taurus_UMD|evm.model.AC_000164.1.1167 Q52LC2 VAS1L_HUMAN 76.555 0.638889 1.44643 ATP6AP1L - V-type proton ATPase subunit S1-like protein - Homo sapiens (Human) - ATP6AP1L gene plasma membrane proton-transporting V-type ATPase complex, regulation of cellular pH Taurus_UMD|evm.model.AC_000164.1.1168 Q5RAL1 KISHA_PONAB 88.710 0.358824 2.36111 TMEM167A - Protein kish-A precursor - Pongo abelii (Sumatran orangutan) - TMEM167A gene Involved in the early part of the secretory pathway. Taurus_UMD|evm.model.AC_000164.1.1169 Q13426 XRCC4_HUMAN 78.274 0.994012 0.994048 XRCC4 - DNA repair protein XRCC4 - Homo sapiens (Human) - XRCC4 gene Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Taurus_UMD|evm.model.AC_000164.1.1170 P81282 CSPG2_BOVIN 99.756 0.842887 0.717243 VCAN - Versican core protein precursor - Bos taurus (Bovine) - VCAN gene May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. Taurus_UMD|evm.model.AC_000164.1.1171 P55252 HPLN1_BOVIN 100.000 0.994366 1.00282 HAPLN1 - Hyaluronan and proteoglycan link protein 1 precursor - Bos taurus (Bovine) - HAPLN1 gene Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix. Taurus_UMD|evm.model.AC_000164.1.1172 O43854 EDIL3_HUMAN 98.551 0.995181 0.864583 EDIL3 - EGF-like repeat and discoidin I-like domain-containing protein 3 precursor - Homo sapiens (Human) - EDIL3 gene Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development. Taurus_UMD|evm.model.AC_000164.1.1173 Q0VC59 NMNA2_BOVIN 84.286 0.475862 0.472313 NMNAT2 - Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 - Bos taurus (Bovine) - NMNAT2 gene Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). Taurus_UMD|evm.model.AC_000164.1.1174 P79398 IF4G2_RABIT 93.103 0.982759 0.0639471 EIF4G2 - Eukaryotic translation initiation factor 4 gamma 2 - Oryctolagus cuniculus (Rabbit) - EIF4G2 gene Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. Taurus_UMD|evm.model.AC_000164.1.1175 Q5NVQ1 HIG1A_PONAB 79.545 0.811321 0.569892 HIGD1A - HIG1 domain family member 1A, mitochondrial - Pongo abelii (Sumatran orangutan) - HIGD1A gene Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). Taurus_UMD|evm.model.AC_000164.1.1176 P60025 COX7C_PANTR 100.000 0.413793 0.920635 COX7C - Cytochrome c oxidase subunit 7C, mitochondrial precursor - Pan troglodytes (Chimpanzee) - COX7C gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000164.1.1177 P50243 DCAM_BOVIN 95.286 0.993289 0.892216 AMD1 - S-adenosylmethionine decarboxylase proenzyme precursor - Bos taurus (Bovine) - AMD1 gene Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. Taurus_UMD|evm.model.AC_000164.1.1179 P09851 RASA1_BOVIN 99.808 0.998086 1.00096 RASA1 - Ras GTPase-activating protein 1 - Bos taurus (Bovine) - RASA1 gene Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21. Taurus_UMD|evm.model.AC_000164.1.1180 Q3ZBL9 CCNH_BOVIN 99.678 0.95679 1.0125 CCNH - Cyclin-H - Bos taurus (Bovine) - CCNH gene Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle (By similarity). Taurus_UMD|evm.model.AC_000164.1.1181 P51991 ROA3_HUMAN 91.111 0.583062 0.812169 HNRNPA3 - Heterogeneous nuclear ribonucleoprotein A3 - Homo sapiens (Human) - HNRNPA3 gene Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000164.1.1182 O46415 FRIL_BOVIN 49.606 0.859375 0.731429 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000164.1.1184 P18700 TBB_STRPU 60.748 0.905882 0.291096 Tubulin beta chain - Strongylocentrotus purpuratus (Purple sea urchin) Taurus_UMD|evm.model.AC_000164.1.1185 Q8NDZ6 T161B_HUMAN 97.125 0.995902 1.00205 TMEM161B - Transmembrane protein 161B - Homo sapiens (Human) - TMEM161B gene Taurus_UMD|evm.model.AC_000164.1.1187 Q2KIA0 MEF2C_BOVIN 86.925 0.9161 1 MEF2C - Myocyte-specific enhancer factor 2C - Bos taurus (Bovine) - MEF2C gene Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Taurus_UMD|evm.model.AC_000164.1.1189 I6VSD2 TM147_CAPHI 67.500 0.988024 0.745536 TMEM147 - Transmembrane protein 147 - Capra hircus (Goat) - TMEM147 gene Component of a ribosome-associated endoplasmic reticulum (ER) translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Together with SEC61 and TMCO1, forms the lipid-filled cavity at the center of the translocon where TMEM147 may insert hydrophobic segments of mutli-pass membrane proteins from the lumen into de central membrane cavity in a process gated by SEC61, and TMCO1 may insert hydrophobic segments of nascent chains from the cytosol into the cavity. Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Taurus_UMD|evm.model.AC_000164.1.1190 O15182 CETN3_HUMAN 98.802 0.988095 1.00599 CETN3 - Centrin-3 - Homo sapiens (Human) - CETN3 gene Plays a fundamental role in microtubule-organizing center structure and function. Taurus_UMD|evm.model.AC_000164.1.1191 A5PJT0 MBLC2_BOVIN 100.000 0.992857 1.00358 MBLAC2 - Metallo-beta-lactamase domain-containing protein 2 - Bos taurus (Bovine) - MBLAC2 gene Taurus_UMD|evm.model.AC_000164.1.1192 O15318 RPC7_HUMAN 90.583 0.991071 1.00448 POLR3G - DNA-directed RNA polymerase III subunit RPC7 - Homo sapiens (Human) - POLR3G gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (PubMed:20154270). May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF- Kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). Taurus_UMD|evm.model.AC_000164.1.1193 Q7Z3D4 LYSM3_HUMAN 89.216 0.993485 1.00327 LYSMD3 - LysM and putative peptidoglycan-binding domain-containing protein 3 - Homo sapiens (Human) - LYSMD3 gene Essential for Golgi structural integrity. Taurus_UMD|evm.model.AC_000164.1.1195 Q8WXG9 AGRV1_HUMAN 93.803 0.951613 0.0589914 ADGRV1 - Adhesion G-protein coupled receptor V1 precursor - Homo sapiens (Human) - ADGRV1 gene G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Involved in the regulation of bone metabolism. Taurus_UMD|evm.model.AC_000164.1.1196 Q0VCA2 ARRD3_BOVIN 100.000 0.995181 1.00242 ARRDC3 - Arrestin domain-containing protein 3 - Bos taurus (Bovine) - ARRDC3 gene Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. Taurus_UMD|evm.model.AC_000164.1.1197 Q5REU2 RL23_PONAB 64.773 0.78481 0.564286 RPL23 - 60S ribosomal protein L23 - Pongo abelii (Sumatran orangutan) - RPL23 gene Taurus_UMD|evm.model.AC_000164.1.1199 Q90733 COT2_CHICK 96.165 0.736383 1.11951 NR2F2 - COUP transcription factor 2 - Gallus gallus (Chicken) - NR2F2 gene Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro) (By similarity). May be involved in motor neuron development. Taurus_UMD|evm.model.AC_000164.1.1200 Q8WUF8 F172A_HUMAN 97.297 0.994609 0.891827 FAM172A - Cotranscriptional regulator FAM172A precursor - Homo sapiens (Human) - FAM172A gene Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity. Taurus_UMD|evm.model.AC_000164.1.1201 Q8IV33 K0825_HUMAN 82.338 0.995037 0.316078 KIAA0825 - Uncharacterized protein KIAA0825 - Homo sapiens (Human) - KIAA0825 gene Taurus_UMD|evm.model.AC_000164.1.1202 Q8IV33 K0825_HUMAN 82.993 0.266423 0.429804 KIAA0825 - Uncharacterized protein KIAA0825 - Homo sapiens (Human) - KIAA0825 gene Taurus_UMD|evm.model.AC_000164.1.1204 A6QR20 SLF1_BOVIN 95.924 0.998031 0.963033 SLF1 - SMC5-SMC6 complex localization factor protein 1 - Bos taurus (Bovine) - SLF1 gene Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions. Taurus_UMD|evm.model.AC_000164.1.1205 Q6DN14 MCTP1_HUMAN 97.996 0.766434 0.715716 MCTP1 - Multiple C2 and transmembrane domain-containing protein 1 - Homo sapiens (Human) - MCTP1 gene Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. Taurus_UMD|evm.model.AC_000164.1.1206 D4ABL6 MCTP1_RAT 79.487 0.52968 0.231501 Mctp1 - Multiple C2 and transmembrane domain-containing protein 1 - Rattus norvegicus (Rat) - Mctp1 gene Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity (By similarity). Overexpression in cultured neurons significantly inhibits neuronal transferrin endocytosis, secretory vesicle retrieval, cell migration, and oxidative stress from glutamate toxicity (PubMed:26195140). Taurus_UMD|evm.model.AC_000164.1.1207 Q0II90 FA81B_BOVIN 100.000 0.995181 1.00242 FAM81B - Protein FAM81B - Bos taurus (Bovine) - FAM81B gene Taurus_UMD|evm.model.AC_000164.1.1208 Q6PGP7 TTC37_HUMAN 92.199 0.998721 1 TTC37 - Tetratricopeptide repeat protein 37 - Homo sapiens (Human) - TTC37 gene Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). Taurus_UMD|evm.model.AC_000164.1.1209 Q148F3 ARSK_BOVIN 90.775 0.996 0.925926 ARSK - Arylsulfatase K precursor - Bos taurus (Bovine) - ARSK gene Taurus_UMD|evm.model.AC_000164.1.1210 O94955 RHBT3_HUMAN 95.902 0.804491 1.23895 RHOBTB3 - Rho-related BTB domain-containing protein 3 - Homo sapiens (Human) - RHOBTB3 gene Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9. Taurus_UMD|evm.model.AC_000164.1.1211 Q8NGU9 GP150_HUMAN 69.565 0.985646 0.481567 GPR150 - Probable G-protein coupled receptor 150 - Homo sapiens (Human) - GPR150 gene Orphan receptor. Taurus_UMD|evm.model.AC_000164.1.1212 Q8TAC1 RFESD_HUMAN 85.987 0.981132 1.01274 RFESD - Rieske domain-containing protein - Homo sapiens (Human) - RFESD gene Taurus_UMD|evm.model.AC_000164.1.1213 Q3T021 SPAT9_BOVIN 100.000 0.992126 1.00395 SPATA9 - Spermatogenesis-associated protein 9 - Bos taurus (Bovine) - SPATA9 gene May play at role in testicular development/spermatogenesis and may be an important factor in male infertility. Taurus_UMD|evm.model.AC_000164.1.1214 P10575 GLRX1_BOVIN 100.000 0.777778 1.27358 GLRX - Glutaredoxin-1 - Bos taurus (Bovine) - GLRX gene Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Taurus_UMD|evm.model.AC_000164.1.1215 O00472 ELL2_HUMAN 92.217 0.993255 0.926562 ELL2 - RNA polymerase II elongation factor ELL2 - Homo sapiens (Human) - ELL2 gene Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. Taurus_UMD|evm.model.AC_000164.1.1216 Q17QM4 EPT1_BOVIN 88.462 0.944444 0.13602 SELENOI - Ethanolaminephosphotransferase 1 - Bos taurus (Bovine) - SELENOI gene Ethanolaminephosphotransferase that catalyzes the transfer of phosphoethanolamine/PE from CDP-ethanolamine to lipid acceptors, the final step in the synthesis of PE via the 'Kennedy' pathway. PE is the second most abundant phospholipid of membranes in mammals and is involved in various membrane-related cellular processes. The enzyme is critical for the synthesis of several PE species and could also catalyze the synthesis of ether-linked phospholipids like plasmanyl- and plasmenyl-PE which could explain it is required for proper myelination and neurodevelopment. Taurus_UMD|evm.model.AC_000164.1.1217 Q9GLR1 NEC1_BOVIN 99.336 0.997347 1.00133 PCSK1 - Neuroendocrine convertase 1 precursor - Bos taurus (Bovine) - PCSK1 gene Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP. Taurus_UMD|evm.model.AC_000164.1.1218 P20811 ICAL_BOVIN 90.659 0.810169 1.25532 CAST - Calpastatin - Bos taurus (Bovine) - CAST gene Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. Taurus_UMD|evm.model.AC_000164.1.1219 Q9NZ08 ERAP1_HUMAN 87.966 0.994698 1.00213 ERAP1 - Endoplasmic reticulum aminopeptidase 1 - Homo sapiens (Human) - ERAP1 gene Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. Taurus_UMD|evm.model.AC_000164.1.1220 A6QPT7 ERAP2_BOVIN 100.000 0.997906 1.00105 ERAP2 - Endoplasmic reticulum aminopeptidase 2 - Bos taurus (Bovine) - ERAP2 gene Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys (By similarity). Taurus_UMD|evm.model.AC_000164.1.1221 Q9UIQ6 LCAP_HUMAN 86.550 0.998053 1.00195 LNPEP - Leucyl-cystinyl aminopeptidase - Homo sapiens (Human) - LNPEP gene Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Taurus_UMD|evm.model.AC_000164.1.1222 F1N5S9 FUND1_BOVIN 82.581 0.987179 1.00645 FUNDC1 - FUN14 domain-containing protein 1 - Bos taurus (Bovine) - FUNDC1 gene Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. Taurus_UMD|evm.model.AC_000164.1.1223 Q5MYT9 OASL2_RAT 32.404 0.540041 0.953033 Oasl2 - 2'-5'-oligoadenylate synthase-like protein 2 - Rattus norvegicus (Rat) - Oasl2 gene Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Synthesizes oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L (By similarity). Taurus_UMD|evm.model.AC_000164.1.1224 Q8N485 LIX1_HUMAN 94.574 0.850993 1.07092 LIX1 - Protein limb expression 1 homolog - Homo sapiens (Human) - LIX1 gene cytoplasm, autophagosome maturation Taurus_UMD|evm.model.AC_000164.1.1225 Q9BVS4 RIOK2_HUMAN 86.957 0.996377 1 RIOK2 - Serine/threonine-protein kinase RIO2 - Homo sapiens (Human) - RIOK2 gene Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). Taurus_UMD|evm.model.AC_000164.1.1228 Q6NW40 RGMB_HUMAN 91.327 0.863135 1.03661 RGMB - Repulsive guidance molecule B precursor - Homo sapiens (Human) - RGMB gene Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth. Taurus_UMD|evm.model.AC_000164.1.1229 O14646 CHD1_HUMAN 98.397 0.760556 1.05263 CHD1 - Chromodomain-helicase-DNA-binding protein 1 - Homo sapiens (Human) - CHD1 gene ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). Taurus_UMD|evm.model.AC_000164.1.1230 P09645 TBA8_CHICK 58.974 0.950617 0.25 Tubulin alpha-8 chain - Gallus gallus (Chicken) Taurus_UMD|evm.model.AC_000164.1.1232 Q8TBP5 F174A_HUMAN 78.981 0.804124 1.02105 FAM174A - Membrane protein FAM174A precursor - Homo sapiens (Human) - FAM174A gene Taurus_UMD|evm.model.AC_000164.1.1233 Q6ZXC9 SIA8D_BOVIN 99.443 0.994444 1.00279 ST8SIA4 - CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase - Bos taurus (Bovine) - ST8SIA4 gene Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells. Taurus_UMD|evm.model.AC_000164.1.1235 Q71MB6 SO4C1_RAT 71.495 0.725557 0.805249 Slco4c1 - Solute carrier organic anion transporter family member 4C1 - Rattus norvegicus (Rat) - Slco4c1 gene Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg. Taurus_UMD|evm.model.AC_000164.1.1236 Q86UG4 SO6A1_HUMAN 59.281 0.247761 0.93185 SLCO6A1 - Solute carrier organic anion transporter family member 6A1 - Homo sapiens (Human) - SLCO6A1 gene integral component of plasma membrane, sodium-independent organic anion transmembrane transporter activity, sodium-independent organic anion transport Taurus_UMD|evm.model.AC_000164.1.1239 Q4R5M0 RL5_MACFA 69.149 0.978723 0.316498 RPL5 - 60S ribosomal protein L5 - Macaca fascicularis (Crab-eating macaque) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Taurus_UMD|evm.model.AC_000164.1.1240 A4FUB7 GIN1_BOVIN 95.777 0.996169 1.04609 GIN1 - Gypsy retrotransposon integrase-like protein 1 - Bos taurus (Bovine) - GIN1 gene Taurus_UMD|evm.model.AC_000164.1.1241 O43314 VIP2_HUMAN 92.277 0.993289 0.95897 PPIP5K2 - Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 - Homo sapiens (Human) - PPIP5K2 gene Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). Taurus_UMD|evm.model.AC_000164.1.1244 Q3ZBS1 MACIR_BOVIN 100.000 0.990385 1.00483 MACIR - Macrophage immunometabolism regulator - Bos taurus (Bovine) - MACIR gene Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages. The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis. May play also a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B. May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells. Taurus_UMD|evm.model.AC_000164.1.1246 Q6AYD6 PDLI2_RAT 40.541 0.0654649 3.02006 Pdlim2 - PDZ and LIM domain protein 2 - Rattus norvegicus (Rat) - Pdlim2 gene Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity). Taurus_UMD|evm.model.AC_000164.1.1247 Q29RH3 NUD12_BOVIN 95.887 0.99568 1.04279 NUDT12 - NAD-capped RNA hydrolase NUDT12 - Bos taurus (Bovine) - NUDT12 gene mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to nutrient stress (By similarity). Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (By similarity). Taurus_UMD|evm.model.AC_000164.1.1250 Q9WV69 DEMA_MOUSE 54.444 0.472222 0.444444 Dmtn - Dematin - Mus musculus (Mouse) - Dmtn gene Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. Taurus_UMD|evm.model.AC_000164.1.1252 P02722 ADT1_BOVIN 97.143 0.897059 0.912752 SLC25A4 - ADP/ATP translocase 1 - Bos taurus (Bovine) - SLC25A4 gene ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (PubMed:7961643). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (PubMed:7961643). Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (By similarity). It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). Taurus_UMD|evm.model.AC_000164.1.1254 P62243 RS8_RAT 75.000 0.531532 0.533654 Rps8 - 40S ribosomal protein S8 - Rattus norvegicus (Rat) - Rps8 gene cytosolic small ribosomal subunit, ribonucleoprotein complex, structural constituent of ribosome, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000164.1.1255 P62243 RS8_RAT 43.023 0.680328 0.586538 Rps8 - 40S ribosomal protein S8 - Rattus norvegicus (Rat) - Rps8 gene cytosolic small ribosomal subunit, ribonucleoprotein complex, structural constituent of ribosome, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000164.1.1256 P62630 EF1A1_RAT 82.500 0.609375 0.138528 Eef1a1 - Elongation factor 1-alpha 1 - Rattus norvegicus (Rat) - Eef1a1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000164.1.1257 P62630 EF1A1_RAT 87.500 0.560284 0.305195 Eef1a1 - Elongation factor 1-alpha 1 - Rattus norvegicus (Rat) - Eef1a1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000164.1.1258 Q9Y520 PRC2C_HUMAN 95.890 0.882591 0.0852901 PRRC2C - Protein PRRC2C - Homo sapiens (Human) - PRRC2C gene Required for efficient formation of stress granules. Taurus_UMD|evm.model.AC_000164.1.1261 P52803 EFNA5_HUMAN 100.000 0.986577 0.653509 EFNA5 - Ephrin-A5 precursor - Homo sapiens (Human) - EFNA5 gene Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. Taurus_UMD|evm.model.AC_000164.1.1264 Q9UF56 FXL17_HUMAN 98.773 0.987805 0.233951 FBXL17 - F-box/LRR-repeat protein 17 - Homo sapiens (Human) - FBXL17 gene Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome (PubMed:30190310). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity). Taurus_UMD|evm.model.AC_000164.1.1266 O43164 PJA2_HUMAN 84.835 0.997139 0.987288 PJA2 - E3 ubiquitin-protein ligase Praja-2 - Homo sapiens (Human) - PJA2 gene Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Taurus_UMD|evm.model.AC_000164.1.1268 Q16706 MA2A1_HUMAN 85.714 0.209172 0.781469 MAN2A1 - Alpha-mannosidase 2 - Homo sapiens (Human) - MAN2A1 gene Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. Taurus_UMD|evm.model.AC_000164.1.1271 C9JQI7 TM232_HUMAN 71.320 0.989114 0.978691 TMEM232 - Transmembrane protein 232 - Homo sapiens (Human) - TMEM232 gene Taurus_UMD|evm.model.AC_000164.1.1272 Q96AG3 S2546_HUMAN 86.571 0.992754 0.990431 SLC25A46 - Solute carrier family 25 member 46 - Homo sapiens (Human) - SLC25A46 gene May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission. Taurus_UMD|evm.model.AC_000164.1.1274 P53563 B2CL1_RAT 91.176 0.417722 0.339056 Bcl2l1 - Bcl-2-like protein 1 - Rattus norvegicus (Rat) - Bcl2l1 gene Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Taurus_UMD|evm.model.AC_000165.1.1 A4IF94 MF14B_BOVIN 100.000 0.996024 1.00199 MFSD14B - Hippocampus abundant transcript-like protein 1 - Bos taurus (Bovine) - MFSD14B gene Taurus_UMD|evm.model.AC_000165.1.2 Q9UJ72 ANX10_HUMAN 82.264 0.821875 0.987654 ANXA10 - Annexin A10 - Homo sapiens (Human) - ANXA10 gene cytoplasm, calcium ion binding Taurus_UMD|evm.model.AC_000165.1.3 Q8IY21 DDX60_HUMAN 50.886 0.882645 0.353388 DDX60 - Probable ATP-dependent RNA helicase DDX60 - Homo sapiens (Human) - DDX60 gene Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). Taurus_UMD|evm.model.AC_000165.1.4 Q9QZ10 ANX10_MOUSE 95.238 0.925373 0.20679 Anxa10 - Annexin A10 - Mus musculus (Mouse) - Anxa10 gene cytoplasm, mitochondrion, calcium ion binding Taurus_UMD|evm.model.AC_000165.1.5 P0C5E3 PALLD_RAT 88.053 0.336819 2.22056 Palld - Palladin - Rattus norvegicus (Rat) - Palld gene Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Plays a role in neurite outgrowth and in the establishment of polarity during neuronal morphogenesis. Participates in the acquisition of the reactive astrocyte morphology. Taurus_UMD|evm.model.AC_000165.1.7 A4IFA7 CBR4_BOVIN 100.000 0.991597 1.00422 CBR4 - 3-oxoacyl-[acyl-carrier-protein] reductase - Bos taurus (Bovine) - CBR4 gene Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). Taurus_UMD|evm.model.AC_000165.1.9 A5D7F8 SH3R1_BOVIN 100.000 0.976552 0.863095 SH3RF1 - E3 ubiquitin-protein ligase SH3RF1 - Bos taurus (Bovine) - SH3RF1 gene Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly. Taurus_UMD|evm.model.AC_000165.1.10 A5D7F8 SH3R1_BOVIN 100.000 0.747126 0.207143 SH3RF1 - E3 ubiquitin-protein ligase SH3RF1 - Bos taurus (Bovine) - SH3RF1 gene Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly. Taurus_UMD|evm.model.AC_000165.1.11 Q96PY6 NEK1_HUMAN 78.866 0.998387 0.985692 NEK1 - Serine/threonine-protein kinase Nek1 - Homo sapiens (Human) - NEK1 gene Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). Taurus_UMD|evm.model.AC_000165.1.12 O18894 CLCN3_RABIT 98.778 0.997558 1.00122 CLCN3 - H(+)/Cl(-) exchange transporter 3 - Oryctolagus cuniculus (Rabbit) - CLCN3 gene Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). Taurus_UMD|evm.model.AC_000165.1.13 A2VDY4 HPF1_BOVIN 100.000 0.994236 1.00289 HPF1 - Histone PARylation factor 1 - Bos taurus (Bovine) - HPF1 gene Cofactor for serine ADP-ribosylation that confers serine specificity on PARP1 and PARP2 and plays a key role in DNA damage response. Initiates the repair of double-strand DNA breaks: recruited to DNA damage sites by PARP1 and PARP2 and switches the amino acid specificity of PARP1 and PARP2 from aspartate or glutamate to serine residues, licensing serine ADP-ribosylation of target proteins. Serine ADP-ribosylation of target proteins, such as histones, promotes decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. HPF1 acts by completing the active site of PARP1 and PARP2: forms a composite active site composed of residues from HPF1 and PARP1 or PARP2. HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1. Taurus_UMD|evm.model.AC_000165.1.14 Q5R435 GRPE2_PONAB 91.975 0.899441 0.795556 GRPEL2 - GrpE protein homolog 2, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - GRPEL2 gene Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). Taurus_UMD|evm.model.AC_000165.1.16 O75121 MFA3L_HUMAN 78.641 0.995012 0.98044 MFAP3L - Microfibrillar-associated protein 3-like precursor - Homo sapiens (Human) - MFAP3L gene May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis. Taurus_UMD|evm.model.AC_000165.1.19 Q5E9N4 AADAT_BOVIN 99.765 0.995305 1.00235 AADAT - Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial precursor - Bos taurus (Bovine) - AADAT gene Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity). Taurus_UMD|evm.model.AC_000165.1.20 Q5E9N4 AADAT_BOVIN 89.928 0.783427 1.24941 AADAT - Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial precursor - Bos taurus (Bovine) - AADAT gene Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity). Taurus_UMD|evm.model.AC_000165.1.22 Q6PCX9 TRI37_MOUSE 87.973 0.779133 0.76795 Trim37 - E3 ubiquitin-protein ligase TRIM37 - Mus musculus (Mouse) - Trim37 gene E3 ubiquitin-protein ligase required to prevent centriole reduplication (By similarity). Probably acts by ubiquitinating positive regulators of centriole reduplication (By similarity). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Taurus_UMD|evm.model.AC_000165.1.23 O94972 TRI37_HUMAN 99.160 0.983333 0.124481 TRIM37 - E3 ubiquitin-protein ligase TRIM37 - Homo sapiens (Human) - TRIM37 gene E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724). Taurus_UMD|evm.model.AC_000165.1.25 P08548 LIN1_NYCCO 61.039 0.977876 0.179365 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Taurus_UMD|evm.model.AC_000165.1.28 Q49A17 GLTL6_HUMAN 95.699 0.920596 0.670549 GALNTL6 - Polypeptide N-acetylgalactosaminyltransferase-like 6 - Homo sapiens (Human) - GALNTL6 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Taurus_UMD|evm.model.AC_000165.1.29 Q49A17 GLTL6_HUMAN 94.545 0.964286 0.093178 GALNTL6 - Polypeptide N-acetylgalactosaminyltransferase-like 6 - Homo sapiens (Human) - GALNTL6 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Taurus_UMD|evm.model.AC_000165.1.30 Q5RFJ6 GALT7_PONAB 92.422 0.996711 0.925419 GALNT7 - N-acetylgalactosaminyltransferase 7 - Pongo abelii (Sumatran orangutan) - GALNT7 gene Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified (By similarity). Taurus_UMD|evm.model.AC_000165.1.31 P26583 HMGB2_HUMAN 100.000 0.990476 1.00478 HMGB2 - High mobility group protein B2 - Homo sapiens (Human) - HMGB2 gene Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity). Taurus_UMD|evm.model.AC_000165.1.33 O75446 SAP30_HUMAN 97.727 0.99095 1.00455 SAP30 - Histone deacetylase complex subunit SAP30 - Homo sapiens (Human) - SAP30 gene Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. Taurus_UMD|evm.model.AC_000165.1.34 P61295 HAND2_RAT 99.394 0.987952 0.764977 Hand2 - Heart- and neural crest derivatives-expressed protein 2 - Rattus norvegicus (Rat) - Hand2 gene Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Taurus_UMD|evm.model.AC_000165.1.38 Q5E9G6 FBX8_BOVIN 100.000 0.99375 1.00313 FBXO8 - F-box only protein 8 - Bos taurus (Bovine) - FBXO8 gene May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential). Taurus_UMD|evm.model.AC_000165.1.39 Q08DB0 CEP44_BOVIN 99.721 0.862651 1.07792 CEP44 - Centrosomal protein of 44 kDa - Bos taurus (Bovine) - CEP44 gene Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome. Taurus_UMD|evm.model.AC_000165.1.40 Q3T0C2 PGDH_BOVIN 99.624 0.992509 1.00376 HPGD - 15-hydroxyprostaglandin dehydrogenase [NAD(+)] - Bos taurus (Bovine) - HPGD gene Primary enzyme catalyzing the conversion of hydroxylated arachidonic acid species to their corresponding oxidized metabolites. Prostaglandin inactivation, catalyzes the first step in the catabolic pathway of the prostaglandins. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Converts 11(R)-HETE to 11-oxo-5,8,12,14-(Z,Z,E,Z)-eicosatetraenoic acid (ETE). Has hydroxylated docosahexaenoic acid metabolites as substrates. Converts resolvins E1, D1 and D2 to their oxo products which represents a mode of resolvins inactivation and stabilizes their anti-inflammatory actions. Taurus_UMD|evm.model.AC_000165.1.41 O75311 GLRA3_HUMAN 95.556 0.350394 0.547414 GLRA3 - Glycine receptor subunit alpha-3 precursor - Homo sapiens (Human) - GLRA3 gene Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity). Taurus_UMD|evm.model.AC_000165.1.42 Q9UKF5 ADA29_HUMAN 63.432 0.97619 0.717073 ADAM29 - Disintegrin and metalloproteinase domain-containing protein 29 precursor - Homo sapiens (Human) - ADAM29 gene May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein. Taurus_UMD|evm.model.AC_000165.1.43 Q9UKF5 ADA29_HUMAN 52.581 0.90219 0.835366 ADAM29 - Disintegrin and metalloproteinase domain-containing protein 29 precursor - Homo sapiens (Human) - ADAM29 gene May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein. Taurus_UMD|evm.model.AC_000165.1.44 O43506 ADA20_HUMAN 56.319 0.986245 1.00138 ADAM20 - Disintegrin and metalloproteinase domain-containing protein 20 precursor - Homo sapiens (Human) - ADAM20 gene May be involved in sperm maturation and/or fertilization. Taurus_UMD|evm.model.AC_000165.1.45 Q9UKF5 ADA29_HUMAN 51.729 0.876984 0.921951 ADAM29 - Disintegrin and metalloproteinase domain-containing protein 29 precursor - Homo sapiens (Human) - ADAM29 gene May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein. Taurus_UMD|evm.model.AC_000165.1.46 O43506 ADA20_HUMAN 51.023 0.951117 0.986226 ADAM20 - Disintegrin and metalloproteinase domain-containing protein 20 precursor - Homo sapiens (Human) - ADAM20 gene May be involved in sperm maturation and/or fertilization. Taurus_UMD|evm.model.AC_000165.1.47 Q8BVB5 DFB42_MOUSE 59.459 0.631579 0.76 Defb42 - Beta-defensin 42 precursor - Mus musculus (Mouse) - Defb42 gene Has bactericidal activity (By similarity). May play a role in the antimicrobial protection of sperm and urogenital tract epithelia (PubMed:16023745). Taurus_UMD|evm.model.AC_000165.1.48 Q8IZU2 WDR17_HUMAN 93.750 0.940299 0.0506808 WDR17 - WD repeat-containing protein 17 - Homo sapiens (Human) - WDR17 gene Taurus_UMD|evm.model.AC_000165.1.49 P07688 CATB_BOVIN 100.000 0.994048 1.00299 CTSB - Cathepsin B precursor - Bos taurus (Bovine) - CTSB gene Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:1856234). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). Taurus_UMD|evm.model.AC_000165.1.50 Q32KR6 FDFT_BOVIN 99.760 0.995215 1.0024 FDFT1 - Squalene synthase - Bos taurus (Bovine) - FDFT1 gene Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Taurus_UMD|evm.model.AC_000165.1.51 Q6IE77 NEIL2_BOVIN 100.000 0.993939 1.00304 NEIL2 - Endonuclease 8-like 2 - Bos taurus (Bovine) - NEIL2 gene Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity). Taurus_UMD|evm.model.AC_000165.1.52 Q0Q0E4 GATA4_CANLF 95.701 0.995485 1.00226 GATA4 - Transcription factor GATA-4 - Canis lupus familiaris (Dog) - GATA4 gene Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development. May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase. Taurus_UMD|evm.model.AC_000165.1.53 P51451 BLK_HUMAN 87.154 0.996016 0.994059 BLK - Tyrosine-protein kinase Blk - Homo sapiens (Human) - BLK gene Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (By similarity). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (By similarity). Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PubMed:8756631). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (By similarity). Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (By similarity). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PubMed:30356214). Taurus_UMD|evm.model.AC_000165.1.54 Q0V7M8 F167A_BOVIN 100.000 0.990566 1.00474 FAM167A - Protein FAM167A - Bos taurus (Bovine) - FAM167A gene Taurus_UMD|evm.model.AC_000165.1.55 Q2KIR8 TDH_BOVIN 100.000 0.994652 1.00268 TDH - L-threonine 3-dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - TDH gene Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism. Taurus_UMD|evm.model.AC_000165.1.56 A7MB43 MTMR9_BOVIN 100.000 0.996364 1.00182 MTMR9 - Myotubularin-related protein 9 - Bos taurus (Bovine) - MTMR9 gene Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate, and MTMR6 binding affinity for phosphorylated phosphatidylinositols (By similarity). Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles. Negatively regulates autophagy, in part via its association with MTMR8. Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6. Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (By similarity). Taurus_UMD|evm.model.AC_000165.1.57 Q5GH57 XKR6_RAT 97.158 0.869369 0.695925 Xkr6 - XK-related protein 6 - Rattus norvegicus (Rat) - Xkr6 gene membrane, plasma membrane, apoptotic process involved in development, engulfment of apoptotic cell, phosphatidylserine exposure on apoptotic cell surface Taurus_UMD|evm.model.AC_000165.1.60 Q5GH57 XKR6_RAT 89.714 0.921788 0.280564 Xkr6 - XK-related protein 6 - Rattus norvegicus (Rat) - Xkr6 gene membrane, plasma membrane, apoptotic process involved in development, engulfment of apoptotic cell, phosphatidylserine exposure on apoptotic cell surface Taurus_UMD|evm.model.AC_000165.1.61 Q96BK5 PINX1_HUMAN 70.405 0.970968 0.945122 PINX1 - PIN2/TERF1-interacting telomerase inhibitor 1 - Homo sapiens (Human) - PINX1 gene Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. Taurus_UMD|evm.model.AC_000165.1.62 Q9BT81 SOX7_HUMAN 83.704 0.99505 1.04124 SOX7 - Transcription factor SOX-7 - Homo sapiens (Human) - SOX7 gene Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. Taurus_UMD|evm.model.AC_000165.1.63 Q2NL11 CH074_BOVIN 87.202 0.994065 1.15017 Uncharacterized protein C8orf74 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000165.1.64 Q8IWN7 RP1L1_HUMAN 48.185 0.761762 0.974167 RP1L1 - Retinitis pigmentosa 1-like 1 protein - Homo sapiens (Human) - RP1L1 gene Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors (By similarity). Taurus_UMD|evm.model.AC_000165.1.65 Q6UWB4 PRS55_HUMAN 62.696 0.974603 0.894886 PRSS55 - Serine protease 55 precursor - Homo sapiens (Human) - PRSS55 gene Probable serine protease, which plays a crucial role in the fertility of male mice including sperm migration and sperm-egg interaction. Taurus_UMD|evm.model.AC_000165.1.66 A0A1B0GVH4 PRS51_HUMAN 50.901 0.827715 1.21364 PRSS51 - Serine protease-like protein 51 precursor - Homo sapiens (Human) - PRSS51 gene Taurus_UMD|evm.model.AC_000165.1.67 Q9D9M0 PRS52_MOUSE 56.126 0.915751 0.850467 Prss52 - Serine protease 52 precursor - Mus musculus (Mouse) - Prss52 gene Probable serine protease. Taurus_UMD|evm.model.AC_000165.1.68 P54149 MSRA_BOVIN 100.000 0.991453 1.00429 MSRA - Mitochondrial peptide methionine sulfoxide reductase precursor - Bos taurus (Bovine) - MSRA gene Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Taurus_UMD|evm.model.AC_000165.1.69 Q642A5 DPOE3_RAT 87.755 0.676056 0.489655 Pole3 - DNA polymerase epsilon subunit 3 - Rattus norvegicus (Rat) - Pole3 gene Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). Taurus_UMD|evm.model.AC_000165.1.70 Q9NQT8 KI13B_HUMAN 86.476 0.942914 1.09365 KIF13B - Kinesin-like protein KIF13B - Homo sapiens (Human) - KIF13B gene Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. Taurus_UMD|evm.model.AC_000165.1.71 Q6NT76 HMBX1_HUMAN 100.000 0.995249 1.00238 HMBOX1 - Homeobox-containing protein 1 - Homo sapiens (Human) - HMBOX1 gene Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958). Taurus_UMD|evm.model.AC_000165.1.73 Q2KJA6 INT9_BOVIN 90.229 0.955128 0.948328 INTS9 - Integrator complex subunit 9 - Bos taurus (Bovine) - INTS9 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Taurus_UMD|evm.model.AC_000165.1.74 O43909 EXTL3_HUMAN 96.953 0.997826 1.00109 EXTL3 - Exostosin-like 3 - Homo sapiens (Human) - EXTL3 gene Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs) (PubMed:28132690, PubMed:28148688). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation (PubMed:22727489). Taurus_UMD|evm.model.AC_000165.1.75 Q61086 FZD3_MOUSE 98.498 0.997001 1.0015 Fzd3 - Frizzled-3 precursor - Mus musculus (Mouse) - Fzd3 gene Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner. Taurus_UMD|evm.model.AC_000165.1.76 Q8IX29 FBX16_HUMAN 87.986 0.826979 1.16781 FBXO16 - F-box only protein 16 - Homo sapiens (Human) - FBXO16 gene Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Taurus_UMD|evm.model.AC_000165.1.77 Q9H8N7 ZN395_HUMAN 84.333 0.996016 0.978558 ZNF395 - Zinc finger protein 395 - Homo sapiens (Human) - ZNF395 gene Plays a role in papillomavirus genes transcription. Taurus_UMD|evm.model.AC_000165.1.78 O62647 PNOC_BOVIN 100.000 0.643382 1.54545 PNOC - Prepronociceptin precursor - Bos taurus (Bovine) - PNOC gene Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Taurus_UMD|evm.model.AC_000165.1.79 Q2KJ61 ELP3_BOVIN 100.000 0.99635 1.00183 ELP3 - Elongator complex protein 3 - Bos taurus (Bovine) - ELP3 gene Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity). Taurus_UMD|evm.model.AC_000165.1.80 Q68CJ6 SLIP_HUMAN 85.031 0.997487 1 NUGGC - Nuclear GTPase SLIP-GC - Homo sapiens (Human) - NUGGC gene Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity). Taurus_UMD|evm.model.AC_000165.1.81 A5PJQ2 SCAR5_BOVIN 100.000 0.94636 1.05455 SCARA5 - Scavenger receptor class A member 5 - Bos taurus (Bovine) - SCARA5 gene Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1). Taurus_UMD|evm.model.AC_000165.1.82 Q96KB5 TOPK_HUMAN 89.164 0.990769 1.00932 PBK - Lymphokine-activated killer T-cell-originated protein kinase - Homo sapiens (Human) - PBK gene Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Taurus_UMD|evm.model.AC_000165.1.83 Q56NI9 ESCO2_HUMAN 79.651 0.990329 0.860233 ESCO2 - N-acetyltransferase ESCO2 - Homo sapiens (Human) - ESCO2 gene Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). Taurus_UMD|evm.model.AC_000165.1.84 Q3SZX8 CCD25_BOVIN 100.000 0.793103 1.25481 CCDC25 - Coiled-coil domain-containing protein 25 - Bos taurus (Bovine) - CCDC25 gene Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility. NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells. Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells. Taurus_UMD|evm.model.AC_000165.1.85 Q6AZY7 SCAR3_HUMAN 89.384 0.925397 1.0396 SCARA3 - Scavenger receptor class A member 3 - Homo sapiens (Human) - SCARA3 gene Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation. Taurus_UMD|evm.model.AC_000165.1.86 P17697 CLUS_BOVIN 100.000 0.995455 1.00228 CLU - Clusterin precursor - Bos taurus (Bovine) - CLU gene Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity (By similarity). Following stress, promotes apoptosis (By similarity). Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (By similarity). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity). Taurus_UMD|evm.model.AC_000165.1.87 Q5R4K6 PKHB2_PONAB 90.991 0.990991 1 PLEKHB2 - Pleckstrin homology domain-containing family B member 2 - Pongo abelii (Sumatran orangutan) - PLEKHB2 gene Involved in retrograde transport of recycling endosomes. Taurus_UMD|evm.model.AC_000165.1.88 A7MB05 TM215_BOVIN 100.000 0.991525 1.00426 TMEM215 - Transmembrane protein 215 - Bos taurus (Bovine) - TMEM215 gene Taurus_UMD|evm.model.AC_000165.1.90 Q02367 NDUB6_BOVIN 100.000 0.984496 1.00781 NDUFB6 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 - Bos taurus (Bovine) - NDUFB6 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000165.1.91 Q9NS56 TOPRS_HUMAN 90.162 0.998073 0.993301 TOPORS - E3 ubiquitin-protein ligase Topors - Homo sapiens (Human) - TOPORS gene Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. Taurus_UMD|evm.model.AC_000165.1.92 Q9GLV6 DDX58_PIG 82.836 0.993637 1.00319 DDX58 - Antiviral innate immune response receptor RIG-I - Sus scrofa (Pig) - DDX58 gene Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons. Ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA ( Taurus_UMD|evm.model.AC_000165.1.93 Q0VCU1 ACOC_BOVIN 99.888 0.941676 1.06074 ACO1 - Cytoplasmic aconitate hydratase - Bos taurus (Bovine) - ACO1 gene Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. Taurus_UMD|evm.model.AC_000165.1.95 Q9TTY4 MAGBA_CANLF 65.414 0.825 0.42328 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Taurus_UMD|evm.model.AC_000165.1.96 Q9N1R0 CABP1_BOVIN 89.916 0.983333 0.530973 CABP1 - Calcium-binding protein 1 - Bos taurus (Bovine) - CABP1 gene Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina. Taurus_UMD|evm.model.AC_000165.1.98 Q56JZ7 ZCRB1_BOVIN 98.618 0.990826 1.00461 ZCRB1 - Zinc finger CCHC-type and RNA-binding motif-containing protein 1 - Bos taurus (Bovine) - ZCRB1 gene U12-type spliceosomal complex, mRNA splicing, via spliceosome Taurus_UMD|evm.model.AC_000165.1.99 Q7L985 LIGO2_HUMAN 98.845 0.996705 1.00165 LINGO2 - Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor - Homo sapiens (Human) - LINGO2 gene extracellular matrix, extracellular space Taurus_UMD|evm.model.AC_000165.1.100 Q96LT7 CI072_HUMAN 98.753 0.995851 1.00208 C9orf72 - Guanine nucleotide exchange C9orf72 - Homo sapiens (Human) - C9orf72 gene Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity (PubMed:27617292). Positively regulates initiation of autophagy by regulating the RAB1A-dependent trafficking of the ATG1/ULK1 kinase complex to the phagophore which leads to autophagosome formation (PubMed:27334615). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131). Plays a role in endosomal trafficking (PubMed:24549040). May be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation (PubMed:27723745). This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of cofilin, leading to cofilin activation (PubMed:27723745). Positively regulates axon extension and axon growth cone size in spinal motor neurons (PubMed:27723745). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity (By similarity). Taurus_UMD|evm.model.AC_000165.1.102 Q29RK9 MOB3B_BOVIN 100.000 0.990783 1.00463 MOB3B - MOB kinase activator 3B - Bos taurus (Bovine) - MOB3B gene Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Taurus_UMD|evm.model.AC_000165.1.103 Q9NQ60 EQTN_HUMAN 51.524 0.947531 1.10204 EQTN - Equatorin precursor - Homo sapiens (Human) - EQTN gene Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. Taurus_UMD|evm.model.AC_000165.1.105 Q7TT28 REXO1_MOUSE 52.068 0.750958 0.430338 Rexo1 - RNA exonuclease 1 homolog - Mus musculus (Mouse) - Rexo1 gene Seems to have no detectable effect on transcription elongation in vitro. Taurus_UMD|evm.model.AC_000165.1.106 Q06807 TIE2_BOVIN 100.000 0.998224 1.00089 TEK - Angiopoietin-1 receptor precursor - Bos taurus (Bovine) - TEK gene Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1, SHC1 and TIE1 (By similarity). Taurus_UMD|evm.model.AC_000165.1.107 Q8BKE9 IFT74_MOUSE 91.833 0.996672 1.00167 Ift74 - Intraflagellar transport protein 74 homolog - Mus musculus (Mouse) - Ift74 gene Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis (By similarity). Taurus_UMD|evm.model.AC_000165.1.108 Q9Y263 PLAP_HUMAN 93.878 0.917937 1.07296 PLAA - Phospholipase A-2-activating protein - Homo sapiens (Human) - PLAA gene Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986). Taurus_UMD|evm.model.AC_000165.1.109 Q2T9W9 CAAP1_BOVIN 100.000 0.99449 1.00276 CAAP1 - Caspase activity and apoptosis inhibitor 1 - Bos taurus (Bovine) - CAAP1 gene Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. Taurus_UMD|evm.model.AC_000165.1.110 O18882 VATL_SHEEP 98.561 0.985714 0.903226 ATP6V0C - V-type proton ATPase 16 kDa proteolipid subunit - Ovis aries (Sheep) - ATP6V0C gene Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Taurus_UMD|evm.model.AC_000165.1.113 Q99877 H2B1N_HUMAN 94.937 0.962963 0.642857 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000165.1.114 Q2TAM9 TUSC1_HUMAN 74.408 0.985714 0.990566 TUSC1 - Tumor suppressor candidate gene 1 protein - Homo sapiens (Human) - TUSC1 gene Taurus_UMD|evm.model.AC_000165.1.115 A6QL94 IZUM3_BOVIN 100.000 0.991701 1.00417 IZUMO3 - Izumo sperm-egg fusion protein 3 precursor - Bos taurus (Bovine) - IZUMO3 gene protein homodimerization activity Taurus_UMD|evm.model.AC_000165.1.117 Q60899 ELAV2_MOUSE 99.714 0.859606 1.12778 Elavl2 - ELAV-like protein 2 - Mus musculus (Mouse) - Elavl2 gene RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (PubMed:8668530). Seems to recognize a GAAA motif (PubMed:8668530). Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR (PubMed:8668530). Taurus_UMD|evm.model.AC_000165.1.119 Q5VZB9 DMRTA_HUMAN 78.529 0.993964 0.986111 DMRTA1 - Doublesex- and mab-3-related transcription factor A1 - Homo sapiens (Human) - DMRTA1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, germ cell development, regulation of transcription by RNA polymerase II, sex differentiation Taurus_UMD|evm.model.AC_000165.1.120 Q3SZV3 EF1G_BOVIN 93.434 0.994723 0.861364 EEF1G - Elongation factor 1-gamma - Bos taurus (Bovine) - EEF1G gene Probably plays a role in anchoring the complex to other cellular components. Taurus_UMD|evm.model.AC_000165.1.121 Q2KJD8 CDN2B_BOVIN 99.237 0.984848 1.00763 CDKN2B - Cyclin-dependent kinase 4 inhibitor B - Bos taurus (Bovine) - CDKN2B gene Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity). Taurus_UMD|evm.model.AC_000165.1.123 Q2KJD8 CDN2B_BOVIN 85.950 0.784314 1.16794 CDKN2B - Cyclin-dependent kinase 4 inhibitor B - Bos taurus (Bovine) - CDKN2B gene Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity). Taurus_UMD|evm.model.AC_000165.1.124 Q3MHF7 MTAP_BOVIN 100.000 0.992958 1.00353 MTAP - S-methyl-5'-thioadenosine phosphorylase - Bos taurus (Bovine) - MTAP gene Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. Taurus_UMD|evm.model.AC_000165.1.125 A7UHZ5 IFNE_PIG 86.458 0.984536 1.00518 IFNE - Interferon epsilon precursor - Sus scrofa (Pig) - IFNE gene Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity). Taurus_UMD|evm.model.AC_000165.1.126 P15696 IFNT1_BOVIN 100.000 0.304813 0.958974 IFNT1 - Interferon tau-1 precursor - Bos taurus (Bovine) - IFNT1 gene Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible. Taurus_UMD|evm.model.AC_000165.1.127 P15696 IFNT1_BOVIN 89.674 0.584665 1.60513 IFNT1 - Interferon tau-1 precursor - Bos taurus (Bovine) - IFNT1 gene Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible. Taurus_UMD|evm.model.AC_000165.1.128 P05008 IFNAB_BOVIN 92.593 0.989474 1.00529 IFNAB - Interferon alpha-B precursor - Bos taurus (Bovine) - IFNAB gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Taurus_UMD|evm.model.AC_000165.1.129 P49876 IFNAF_BOVIN 95.349 0.332468 2.03704 IFNAF - Interferon alpha-F precursor - Bos taurus (Bovine) - IFNAF gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Taurus_UMD|evm.model.AC_000165.1.130 P07352 IFNW1_BOVIN 88.718 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.131 P07352 IFNW1_BOVIN 90.000 0.72973 1.32821 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.132 P07352 IFNW1_BOVIN 89.744 0.989796 1.00513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.133 P49876 IFNAF_BOVIN 97.354 0.989474 1.00529 IFNAF - Interferon alpha-F precursor - Bos taurus (Bovine) - IFNAF gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Taurus_UMD|evm.model.AC_000165.1.134 P07352 IFNW1_BOVIN 86.082 0.873303 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.135 P07352 IFNW1_BOVIN 90.811 0.872038 1.08205 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.136 P07348 IFNA1_BOVIN 99.471 0.989474 1.00529 Interferon alpha-1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000165.1.137 P07352 IFNW1_BOVIN 100.000 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.138 P07352 IFNW1_BOVIN 83.333 0.872642 1.08718 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.139 P05008 IFNAB_BOVIN 93.651 0.989474 1.00529 IFNAB - Interferon alpha-B precursor - Bos taurus (Bovine) - IFNAB gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Taurus_UMD|evm.model.AC_000165.1.140 P07352 IFNW1_BOVIN 89.005 0.86758 1.12308 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.141 P07352 IFNW1_BOVIN 88.205 0.854626 1.1641 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.142 P49877 IFNAG_BOVIN 95.767 0.989474 1.00529 IFNAG - Interferon alpha-G precursor - Bos taurus (Bovine) - IFNAG gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Taurus_UMD|evm.model.AC_000165.1.143 Q9P2J3 KLHL9_HUMAN 99.352 0.996764 1.00162 KLHL9 - Kelch-like protein 9 - Homo sapiens (Human) - KLHL9 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. Taurus_UMD|evm.model.AC_000165.1.145 P49877 IFNAG_BOVIN 96.825 0.989474 1.00529 IFNAG - Interferon alpha-G precursor - Bos taurus (Bovine) - IFNAG gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Taurus_UMD|evm.model.AC_000165.1.146 P07352 IFNW1_BOVIN 90.256 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.147 P07352 IFNW1_BOVIN 89.785 0.872642 1.08718 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.148 P07352 IFNW1_BOVIN 90.769 0.989796 1.00513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.149 P05009 IFNAC_BOVIN 98.942 0.989474 1.00529 IFNAC - Interferon alpha-C precursor - Bos taurus (Bovine) - IFNAC gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Taurus_UMD|evm.model.AC_000165.1.150 P07352 IFNW1_BOVIN 87.692 0.989796 1.00513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.151 P07352 IFNW1_BOVIN 89.744 0.989796 1.00513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.153 P07352 IFNW1_BOVIN 88.043 0.924242 1.01538 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.154 P07352 IFNW1_BOVIN 89.231 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.155 P07352 IFNW1_BOVIN 90.256 0.989796 1.00513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.156 P07352 IFNW1_BOVIN 89.231 0.321725 3.09231 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.157 P49878 IFNAH_BOVIN 95.767 0.944724 1.05291 IFNAH - Interferon alpha-H precursor - Bos taurus (Bovine) - IFNAH gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Taurus_UMD|evm.model.AC_000165.1.158 P49878 IFNAH_BOVIN 97.354 0.989474 1.00529 IFNAH - Interferon alpha-H precursor - Bos taurus (Bovine) - IFNAH gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Taurus_UMD|evm.model.AC_000165.1.159 P07352 IFNW1_BOVIN 89.744 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.160 P07352 IFNW1_BOVIN 88.205 0.989796 1.00513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.161 P07352 IFNW1_BOVIN 89.231 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.163 P07352 IFNW1_BOVIN 90.256 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.164 P49878 IFNAH_BOVIN 95.238 0.989474 1.00529 IFNAH - Interferon alpha-H precursor - Bos taurus (Bovine) - IFNAH gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Taurus_UMD|evm.model.AC_000165.1.165 P07352 IFNW1_BOVIN 88.718 0.989796 1.00513 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.166 P01577 IFNB3_BOVIN 87.273 0.302778 1.93548 IFNB3 - Interferon beta-3 precursor - Bos taurus (Bovine) - IFNB3 gene Has antiviral, antibacterial and anticancer activities. Taurus_UMD|evm.model.AC_000165.1.168 P01577 IFNB3_BOVIN 99.219 0.709497 0.962366 IFNB3 - Interferon beta-3 precursor - Bos taurus (Bovine) - IFNB3 gene Has antiviral, antibacterial and anticancer activities. Taurus_UMD|evm.model.AC_000165.1.169 P01577 IFNB3_BOVIN 100.000 0.984733 0.704301 IFNB3 - Interferon beta-3 precursor - Bos taurus (Bovine) - IFNB3 gene Has antiviral, antibacterial and anticancer activities. Taurus_UMD|evm.model.AC_000165.1.170 P01577 IFNB3_BOVIN 100.000 0.489362 1.01075 IFNB3 - Interferon beta-3 precursor - Bos taurus (Bovine) - IFNB3 gene Has antiviral, antibacterial and anticancer activities. Taurus_UMD|evm.model.AC_000165.1.171 P01576 IFNB2_BOVIN 86.207 0.41791 0.360215 IFNB2 - Interferon beta-2 precursor - Bos taurus (Bovine) - IFNB2 gene Has antiviral, antibacterial and anticancer activities. Taurus_UMD|evm.model.AC_000165.1.174 P07352 IFNW1_BOVIN 81.188 0.75188 0.682051 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.175 P05004 IFNA2_HORSE 50.829 0.957219 1.0163 Interferon alpha-2 precursor - Equus caballus (Horse) Taurus_UMD|evm.model.AC_000165.1.176 P01578 IFNB1_BOVIN 96.774 0.989305 1.00538 IFNB1 - Interferon beta-1 precursor - Bos taurus (Bovine) - IFNB1 gene Has antiviral, antibacterial and anticancer activities. Taurus_UMD|evm.model.AC_000165.1.177 P01569 IFNA5_HUMAN 49.167 0.975207 0.640212 IFNA5 - Interferon alpha-5 precursor - Homo sapiens (Human) - IFNA5 gene Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Taurus_UMD|evm.model.AC_000165.1.178 P01578 IFNB1_BOVIN 95.161 0.989305 1.00538 IFNB1 - Interferon beta-1 precursor - Bos taurus (Bovine) - IFNB1 gene Has antiviral, antibacterial and anticancer activities. Taurus_UMD|evm.model.AC_000165.1.179 P07352 IFNW1_BOVIN 71.186 0.745223 0.805128 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.AC_000165.1.180 P05005 IFNA3_HORSE 52.601 0.913978 1.01087 Interferon alpha-3 precursor - Equus caballus (Horse) Taurus_UMD|evm.model.AC_000165.1.181 P01576 IFNB2_BOVIN 90.244 0.588448 1.48925 IFNB2 - Interferon beta-2 precursor - Bos taurus (Bovine) - IFNB2 gene Has antiviral, antibacterial and anticancer activities. Taurus_UMD|evm.model.AC_000165.1.182 P07348 IFNA1_BOVIN 52.344 0.926471 0.719577 Interferon alpha-1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000165.1.183 P01576 IFNB2_BOVIN 100.000 0.548611 1.54839 IFNB2 - Interferon beta-2 precursor - Bos taurus (Bovine) - IFNB2 gene Has antiviral, antibacterial and anticancer activities. Taurus_UMD|evm.model.AC_000165.1.184 P01576 IFNB2_BOVIN 95.161 0.989305 1.00538 IFNB2 - Interferon beta-2 precursor - Bos taurus (Bovine) - IFNB2 gene Has antiviral, antibacterial and anticancer activities. Taurus_UMD|evm.model.AC_000165.1.185 Q0P5C7 HACD4_BOVIN 99.567 0.991379 1.00433 HACD4 - Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 - Bos taurus (Bovine) - HACD4 gene Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Taurus_UMD|evm.model.AC_000165.1.186 Q5VW36 FOCAD_HUMAN 89.583 0.0304997 0.855636 FOCAD - Focadhesin - Homo sapiens (Human) - FOCAD gene Potential tumor suppressor in gliomas. Taurus_UMD|evm.model.AC_000165.1.187 P42568 AF9_HUMAN 90.088 0.994197 0.910211 MLLT3 - Protein AF-9 - Homo sapiens (Human) - MLLT3 gene Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than confering, HSC stemness (PubMed:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511). Taurus_UMD|evm.model.AC_000165.1.188 Q9UI40 NCKX2_HUMAN 89.608 0.996914 0.980333 SLC24A2 - Sodium/potassium/calcium exchanger 2 - Homo sapiens (Human) - SLC24A2 gene Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Taurus_UMD|evm.model.AC_000165.1.189 Q5QJU3 ACER2_HUMAN 95.273 0.992754 1.00364 ACER2 - Alkaline ceramidase 2 - Homo sapiens (Human) - ACER2 gene Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:16940153, PubMed:18945876, PubMed:20207939, PubMed:20089856). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20207939). Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides (PubMed:16940153, PubMed:18945876, PubMed:20207939, PubMed:20089856). Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates (PubMed:20089856). Also hydrolyzes dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (By similarity). Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate (PubMed:16940153, PubMed:26943039, PubMed:28294157, PubMed:29229990). As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage (PubMed:26943039, PubMed:28294157, PubMed:29229990). Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins (PubMed:18945876). Taurus_UMD|evm.model.AC_000165.1.190 Q5E995 RS6_BOVIN 98.551 0.919643 0.899598 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Taurus_UMD|evm.model.AC_000165.1.191 Q5VZ89 DEN4C_HUMAN 88.974 0.889092 1.14772 DENND4C - DENN domain-containing protein 4C - Homo sapiens (Human) - DENND4C gene Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. Taurus_UMD|evm.model.AC_000165.1.192 Q9TUM6 PLIN2_BOVIN 96.651 0.930804 0.995556 PLIN2 - Perilipin-2 - Bos taurus (Bovine) - PLIN2 gene May be involved in development and maintenance of adipose tissue. Taurus_UMD|evm.model.AC_000165.1.193 Q7Z4H7 HAUS6_HUMAN 75.052 0.99791 1.00209 HAUS6 - HAUS augmin-like complex subunit 6 - Homo sapiens (Human) - HAUS6 gene Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. Taurus_UMD|evm.model.AC_000165.1.194 Q63486 RRAGA_RAT 100.000 0.993631 1.00319 Rraga - Ras-related GTP-binding protein A - Rattus norvegicus (Rat) - Rraga gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. Taurus_UMD|evm.model.AC_000165.1.195 Q8IYX7 SAXO1_HUMAN 81.818 0.987448 1.00844 SAXO1 - Stabilizer of axonemal microtubules 1 - Homo sapiens (Human) - SAXO1 gene May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature. Taurus_UMD|evm.model.AC_000165.1.196 Q8N6G6 ATL1_HUMAN 67.617 0.977081 0.940976 ADAMTSL1 - ADAMTS-like protein 1 precursor - Homo sapiens (Human) - ADAMTSL1 gene endoplasmic reticulum lumen, extracellular matrix, metalloendopeptidase activity, extracellular matrix organization Taurus_UMD|evm.model.AC_000165.1.197 P70081 H48_CHICK 97.531 0.5 1.5534 H4-VIII - Histone H4 type VIII - Gallus gallus (Chicken) - H4-VIII gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000165.1.200 O35179 SH3G2_RAT 97.947 0.991254 0.974432 Sh3gl2 - Endophilin-A1 - Rattus norvegicus (Rat) - Sh3gl2 gene Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (By similarity). Taurus_UMD|evm.model.AC_000165.1.201 Q9Y4B5 MTCL1_HUMAN 41.767 0.9 0.110236 MTCL1 - Microtubule cross-linking factor 1 - Homo sapiens (Human) - MTCL1 gene Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Taurus_UMD|evm.model.AC_000165.1.202 Q9NXG0 CNTLN_HUMAN 83.053 0.883234 0.713167 CNTLN - Centlein - Homo sapiens (Human) - CNTLN gene Required for centrosome cohesion and recruitment of CEP68 to centrosomes. Taurus_UMD|evm.model.AC_000165.1.203 Q6ZN30 BNC2_HUMAN 97.917 0.909483 1.05551 BNC2 - Zinc finger protein basonuclin-2 - Homo sapiens (Human) - BNC2 gene Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes (PubMed:14988505). May also play an important role in early urinary-tract development (PubMed:31051115). Taurus_UMD|evm.model.AC_000165.1.204 P16116 ALDR_BOVIN 98.500 0.786561 0.803175 AKR1B1 - Aldo-keto reductase family 1 member B1 - Bos taurus (Bovine) - AKR1B1 gene Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Taurus_UMD|evm.model.AC_000165.1.205 Q6TFL3 CC171_HUMAN 87.640 0.998451 0.973605 CCDC171 - Coiled-coil domain-containing protein 171 - Homo sapiens (Human) - CCDC171 gene Taurus_UMD|evm.model.AC_000165.1.206 Q8MJG1 PSIP1_BOVIN 90.000 0.995833 0.90566 PSIP1 - PC4 and SFRS1-interacting protein - Bos taurus (Bovine) - PSIP1 gene Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity). Taurus_UMD|evm.model.AC_000165.1.207 Q5E9M5 SNPC3_BOVIN 88.592 0.995098 0.990291 SNAPC3 - snRNA-activating protein complex subunit 3 - Bos taurus (Bovine) - SNAPC3 gene Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity). Taurus_UMD|evm.model.AC_000165.1.208 Q95LT8 TT39B_MACFA 88.795 0.952998 0.976266 TTC39B - Tetratricopeptide repeat protein 39B - Macaca fascicularis (Crab-eating macaque) - TTC39B gene Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3). Taurus_UMD|evm.model.AC_000165.1.209 Q5H8C1 FREM1_HUMAN 83.568 0.999028 0.94447 FREM1 - FRAS1-related extracellular matrix protein 1 precursor - Homo sapiens (Human) - FREM1 gene Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development. Taurus_UMD|evm.model.AC_000165.1.210 O95813 CER1_HUMAN 73.993 0.992701 1.02622 CER1 - Cerberus precursor - Homo sapiens (Human) - CER1 gene Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity). Taurus_UMD|evm.model.AC_000165.1.211 A2VDT6 ZDH21_BOVIN 100.000 0.992481 1.00377 ZDHHC21 - Palmitoyltransferase ZDHHC21 - Bos taurus (Bovine) - ZDHHC21 gene Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity). Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK (By similarity). Taurus_UMD|evm.model.AC_000165.1.212 Q99068 AMRP_RAT 76.398 0.879121 0.505556 Lrpap1 - Alpha-2-macroglobulin receptor-associated protein precursor - Rattus norvegicus (Rat) - Lrpap1 gene Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. Taurus_UMD|evm.model.AC_000165.1.213 P17924 NFIB_CHICK 93.564 0.980488 0.366071 NFIB - Nuclear factor 1 B-type - Gallus gallus (Chicken) - NFIB gene Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Taurus_UMD|evm.model.AC_000165.1.214 Q0VCL6 NFIB_BOVIN 100.000 0.904762 0.55 NFIB - Nuclear factor 1 B-type - Bos taurus (Bovine) - NFIB gene Transcriptional activator of GFAP, essential for proper brain development. Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Taurus_UMD|evm.model.AC_000165.1.216 Q9HB90 RRAGC_HUMAN 83.333 0.601266 0.39599 RRAGC - Ras-related GTP-binding protein C - Homo sapiens (Human) - RRAGC gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:27234373, PubMed:24095279). Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form (PubMed:24095279). In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:27234373, PubMed:24095279). This is a crucial step in the activation of the TOR signaling cascade by amino acids (PubMed:20381137, PubMed:27234373, PubMed:24095279). Taurus_UMD|evm.model.AC_000165.1.217 O75970 MPDZ_HUMAN 88.605 0.999017 0.982609 MPDZ - Multiple PDZ domain protein - Homo sapiens (Human) - MPDZ gene Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). Taurus_UMD|evm.model.AC_000165.1.218 Q9DAW9 CNN3_MOUSE 84.211 0.986667 0.454545 Cnn3 - Calponin-3 - Mus musculus (Mouse) - Cnn3 gene Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). Taurus_UMD|evm.model.AC_000165.1.219 Q8IV03 LUR1L_HUMAN 84.914 0.991189 0.982684 LURAP1L - Leucine rich adaptor protein 1-like - Homo sapiens (Human) - LURAP1L gene Taurus_UMD|evm.model.AC_000165.1.220 Q8WN57 TYRP1_BOVIN 99.620 0.996205 0.981378 TYRP1 - 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor - Bos taurus (Bovine) - TYRP1 gene Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. Taurus_UMD|evm.model.AC_000165.1.221 P67937 TPM4_PIG 89.516 0.991561 0.955645 TPM4 - Tropomyosin alpha-4 chain - Sus scrofa (Pig) - TPM4 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. Taurus_UMD|evm.model.AC_000165.1.222 P39023 RL3_HUMAN 79.310 0.118644 0.585608 RPL3 - 60S ribosomal protein L3 - Homo sapiens (Human) - RPL3 gene The L3 protein is a component of the large subunit of cytoplasmic ribosomes. Taurus_UMD|evm.model.AC_000165.1.223 Q3SZQ6 RL32_BOVIN 88.060 0.725275 0.674074 RPL32 - 60S ribosomal protein L32 - Bos taurus (Bovine) - RPL32 gene cytosolic large ribosomal subunit Taurus_UMD|evm.model.AC_000165.1.224 P62912 RL32_RAT 92.593 0.963636 0.407407 Rpl32 - 60S ribosomal protein L32 - Rattus norvegicus (Rat) - Rpl32 gene cytosolic large ribosomal subunit, polysomal ribosome, cellular response to dexamethasone stimulus, cytoplasmic translation, liver regeneration Taurus_UMD|evm.model.AC_000165.1.225 A5PJP6 BRCC3_BOVIN 82.243 0.981308 0.338608 BRCC3 - Lys-63-specific deubiquitinase BRCC36 - Bos taurus (Bovine) - BRCC3 gene Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Taurus_UMD|evm.model.AC_000165.1.227 Q8NHW5 RLA0L_HUMAN 87.324 0.958904 0.230284 RPLP0P6 - 60S acidic ribosomal protein P0-like - Homo sapiens (Human) - RPLP0P6 gene Ribosomal protein P0 is the functional equivalent of E.coli protein L10. Taurus_UMD|evm.model.AC_000165.1.229 P23468 PTPRD_HUMAN 97.439 0.998943 0.98954 PTPRD - Receptor-type tyrosine-protein phosphatase delta precursor - Homo sapiens (Human) - PTPRD gene Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. Taurus_UMD|evm.model.AC_000165.1.230 O15439 MRP4_HUMAN 75.490 0.808 0.0943396 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000165.1.231 Q9H3R0 KDM4C_HUMAN 85.464 0.997301 0.701705 KDM4C - Lysine-specific demethylase 4C - Homo sapiens (Human) - KDM4C gene Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Taurus_UMD|evm.model.AC_000165.1.232 Q9H3R0 KDM4C_HUMAN 91.758 0.59375 0.272727 KDM4C - Lysine-specific demethylase 4C - Homo sapiens (Human) - KDM4C gene Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Taurus_UMD|evm.model.AC_000165.1.233 O95372 LYPA2_HUMAN 89.375 0.987578 0.69697 LYPLA2 - Acyl-protein thioesterase 2 - Homo sapiens (Human) - LYPLA2 gene Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951). Taurus_UMD|evm.model.AC_000165.1.234 P23378 GCSP_HUMAN 93.725 0.998041 1.00098 GLDC - Glycine dehydrogenase (decarboxylating), mitochondrial precursor - Homo sapiens (Human) - GLDC gene The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH). Taurus_UMD|evm.model.AC_000165.1.235 Q96PU4 UHRF2_HUMAN 90.250 0.990826 0.951372 UHRF2 - E3 ubiquitin-protein ligase UHRF2 - Homo sapiens (Human) - UHRF2 gene E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131. Taurus_UMD|evm.model.AC_000165.1.236 Q5R592 RPAB2_PONAB 98.425 0.984375 1.00787 POLR2F - DNA-directed RNA polymerases I, II, and III subunit RPABC2 - Pongo abelii (Sumatran orangutan) - POLR2F gene DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity). Taurus_UMD|evm.model.AC_000165.1.237 Q96J77 TPD55_HUMAN 77.206 0.553279 1.74286 TPD52L3 - Tumor protein D55 - Homo sapiens (Human) - TPD52L3 gene cytoplasm Taurus_UMD|evm.model.AC_000165.1.238 O97863 IL33_CANLF 67.286 0.967153 1.04183 IL33 - Interleukin-33 precursor - Canis lupus familiaris (Dog) - IL33 gene Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity). Taurus_UMD|evm.model.AC_000165.1.239 O60518 RNBP6_HUMAN 97.557 0.998192 1.0009 RANBP6 - Ran-binding protein 6 - Homo sapiens (Human) - RANBP6 gene May function in nuclear protein import as nuclear transport receptor. Taurus_UMD|evm.model.AC_000165.1.240 Q5HYC2 K2026_HUMAN 85.640 0.999036 0.98621 KIAA2026 - Uncharacterized protein KIAA2026 - Homo sapiens (Human) - KIAA2026 gene Taurus_UMD|evm.model.AC_000165.1.241 Q16655 MAR1_HUMAN 58.974 0.621849 1.00847 MLANA - Melanoma antigen recognized by T-cells 1 - Homo sapiens (Human) - MLANA gene Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. Taurus_UMD|evm.model.AC_000165.1.242 Q7Z2K6 ERMP1_HUMAN 92.201 0.9925 0.884956 ERMP1 - Endoplasmic reticulum metallopeptidase 1 - Homo sapiens (Human) - ERMP1 gene Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures. Taurus_UMD|evm.model.AC_000165.1.243 Q4ADV7 RIC1_HUMAN 95.576 0.998595 1 RIC1 - Guanine nucleotide exchange factor subunit RIC1 - Homo sapiens (Human) - RIC1 gene The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment (PubMed:23091056). The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors (PubMed:23091056). Required for phosphorylation and localization of GJA1 (PubMed:16112082). Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton (PubMed:31932796). Taurus_UMD|evm.model.AC_000165.1.244 Q9BQ51 PD1L2_HUMAN 69.884 0.905263 1.04396 PDCD1LG2 - Programmed cell death 1 ligand 2 precursor - Homo sapiens (Human) - PDCD1LG2 gene Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity). Taurus_UMD|evm.model.AC_000165.1.245 Q9NZQ7 PD1L1_HUMAN 73.196 0.993103 1 CD274 - Programmed cell death 1 ligand 1 precursor - Homo sapiens (Human) - CD274 gene Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). Taurus_UMD|evm.model.AC_000165.1.246 Q9HBL7 PLRKT_HUMAN 83.673 0.986486 1.0068 PLGRKT - Plasminogen receptor (KT) - Homo sapiens (Human) - PLGRKT gene Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9. Taurus_UMD|evm.model.AC_000165.1.247 Q32L79 INSL6_BOVIN 100.000 0.990291 1.00488 INSL6 - Insulin-like peptide INSL6 precursor - Bos taurus (Bovine) - INSL6 gene May have a role in sperm development and fertilization. Taurus_UMD|evm.model.AC_000165.1.248 O19064 JAK2_PIG 96.994 0.997352 1.00177 JAK2 - Tyrosine-protein kinase JAK2 - Sus scrofa (Pig) - JAK2 gene Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin. Taurus_UMD|evm.model.AC_000165.1.249 Q2KHX8 RCL1_BOVIN 93.566 0.994286 0.938338 RCL1 - RNA 3'-terminal phosphate cyclase-like protein - Bos taurus (Bovine) - RCL1 gene Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity). Taurus_UMD|evm.model.AC_000165.1.250 P08760 KAD3_BOVIN 100.000 0.991228 1.00441 AK3 - GTP:AMP phosphotransferase AK3, mitochondrial - Bos taurus (Bovine) - AK3 gene Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. Taurus_UMD|evm.model.AC_000165.1.251 A6H754 CD37L_BOVIN 100.000 0.994083 1.00297 CDC37L1 - Hsp90 co-chaperone Cdc37-like 1 - Bos taurus (Bovine) - CDC37L1 gene Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. Taurus_UMD|evm.model.AC_000165.1.252 Q5R7C4 SERF2_PONAB 96.610 0.966667 1.01695 SERF2 - Small EDRK-rich factor 2 - Pongo abelii (Sumatran orangutan) - SERF2 gene Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity). Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates (By similarity). Taurus_UMD|evm.model.AC_000165.1.253 Q58DI5 PLPP6_BOVIN 100.000 0.993103 1.00346 PLPP6 - Phospholipid phosphatase 6 - Bos taurus (Bovine) - PLPP6 gene Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid (By similarity). Taurus_UMD|evm.model.AC_000165.1.254 Q8N4H0 SPA6L_HUMAN 71.386 0.776995 1.08673 SPATA6L - Spermatogenesis associated 6-like protein - Homo sapiens (Human) - SPATA6L gene Taurus_UMD|evm.model.AC_000165.1.255 Q95135 EAA3_BOVIN 92.939 0.995951 0.942748 SLC1A1 - Excitatory amino acid transporter 3 - Bos taurus (Bovine) - SLC1A1 gene Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine (By similarity). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport. Negatively regulated by ARL6IP5 (By similarity). Taurus_UMD|evm.model.AC_000165.1.256 P13060 EF2_DROME 41.844 0.604545 0.260664 eEF2 - Eukaryotic translation elongation factor 2 - Drosophila melanogaster (Fruit fly) - eEF2 gene Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). Taurus_UMD|evm.model.AC_000165.1.257 Q8NEA6 GLIS3_HUMAN 88.197 0.782875 1.26581 GLIS3 - Zinc finger protein GLIS3 - Homo sapiens (Human) - GLIS3 gene Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). Taurus_UMD|evm.model.AC_000165.1.258 Q8WY07 CTR3_HUMAN 53.055 0.401894 1.19386 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000165.1.259 Q4R3I8 RFX3_MACFA 99.437 0.939153 1.00935 RFX3 - Transcription factor RFX3 - Macaca fascicularis (Crab-eating macaque) - RFX3 gene Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes. Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (By similarity). Taurus_UMD|evm.model.AC_000165.1.260 Q29B63 CARM1_DROPS 79.032 0.2891 0.397363 Art4 - Histone-arginine methyltransferase CARMER - Drosophila pseudoobscura pseudoobscura (Fruit fly) - Art4 gene Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in proteins. May methylate histone H3 at 'Arg-17' and activate transcription via chromatin remodeling (By similarity). Taurus_UMD|evm.model.AC_000165.1.261 Q15397 PUM3_HUMAN 91.358 0.996914 1 PUM3 - Pumilio homolog 3 - Homo sapiens (Human) - PUM3 gene Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity). Taurus_UMD|evm.model.AC_000165.1.262 Q8CFS6 KCNV2_MOUSE 81.770 0.991182 1.0089 Kcnv2 - Potassium voltage-gated channel subfamily V member 2 - Mus musculus (Mouse) - Kcnv2 gene Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (By similarity). Taurus_UMD|evm.model.AC_000165.1.263 P98155 VLDLR_HUMAN 93.700 0.997636 0.969072 VLDLR - Very low-density lipoprotein receptor precursor - Homo sapiens (Human) - VLDLR gene Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). Taurus_UMD|evm.model.AC_000165.1.265 P0DOH2 GGAG_FSVMD 43.103 0.965812 0.218284 Glyco-Gag protein - Feline sarcoma virus (strain McDonough) Taurus_UMD|evm.model.AC_000165.1.266 O14490 DLGP1_HUMAN 91.729 0.979167 0.54043 DLGAP1 - Disks large-associated protein 1 - Homo sapiens (Human) - DLGAP1 gene Part of the postsynaptic scaffold in neuronal cells. Taurus_UMD|evm.model.AC_000165.1.267 P51531 SMCA2_HUMAN 97.233 0.998729 0.989308 SMARCA2 - Probable global transcription activator SNF2L2 - Homo sapiens (Human) - SMARCA2 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Taurus_UMD|evm.model.AC_000165.1.269 Q9Y5R5 DMRT2_HUMAN 85.918 0.996422 0.996435 DMRT2 - Doublesex- and mab-3-related transcription factor 2 - Homo sapiens (Human) - DMRT2 gene Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity). Taurus_UMD|evm.model.AC_000165.1.270 F6W2R2 DMRT3_HORSE 89.032 0.99568 0.976793 DMRT3 - Doublesex and mab-3 related transcription factor 3 - Equus caballus (Horse) - DMRT3 gene Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within a specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development. Taurus_UMD|evm.model.AC_000165.1.271 C0LZJ1 DMRT1_BOVIN 89.655 0.367742 0.434174 DMRT1 - Doublesex and mab-3 related transcription factor 1 - Bos taurus (Bovine) - DMRT1 gene Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). Taurus_UMD|evm.model.AC_000165.1.272 C0LZJ1 DMRT1_BOVIN 99.035 0.981013 0.885154 DMRT1 - Doublesex and mab-3 related transcription factor 1 - Bos taurus (Bovine) - DMRT1 gene Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). Taurus_UMD|evm.model.AC_000165.1.273 Q14678 KANK1_HUMAN 88.733 0.998525 1.00296 KANK1 - KN motif and ankyrin repeat domain-containing protein 1 - Homo sapiens (Human) - KANK1 gene Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration (PubMed:25961457). Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1 (PubMed:25961457). Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways (PubMed:25961457). Taurus_UMD|evm.model.AC_000165.1.274 Q8NF50 DOCK8_HUMAN 93.435 0.999047 1 DOCK8 - Dedicator of cytokinesis protein 8 - Homo sapiens (Human) - DOCK8 gene Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). Taurus_UMD|evm.model.AC_000165.1.275 Q8IUF1 CBWD2_HUMAN 88.161 0.992481 1.01013 CBWD2 - COBW domain-containing protein 2 - Homo sapiens (Human) - CBWD2 gene cytoplasm Taurus_UMD|evm.model.AC_000165.1.276 Q63249 FOXD4_RAT 100.000 0.217391 4.55446 Foxd4 - Forkhead box protein D4 - Rattus norvegicus (Rat) - Foxd4 gene DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, anatomical structure morphogenesis, cell differentiation, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000165.1.277 Q8BZF8 PGM5_MOUSE 98.413 0.996479 1.00176 Pgm5 - Phosphoglucomutase-like protein 5 - Mus musculus (Mouse) - Pgm5 gene Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity (By similarity). Taurus_UMD|evm.model.AC_000165.1.278 Q8N6L7 TM252_HUMAN 66.082 0.988372 1.01176 TMEM252 - Transmembrane protein 252 - Homo sapiens (Human) - TMEM252 gene Taurus_UMD|evm.model.AC_000165.1.280 Q96E09 PBIR1_HUMAN 97.561 0.866667 1.14983 PABIR1 - PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 - Homo sapiens (Human) - PABIR1 gene Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). Taurus_UMD|evm.model.AC_000165.1.281 O14986 PI51B_HUMAN 96.667 0.996296 1 PIP5K1B - Phosphatidylinositol 4-phosphate 5-kinase type-1 beta - Homo sapiens (Human) - PIP5K1B gene Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Taurus_UMD|evm.model.AC_000165.1.282 Q05B87 FRDA_BOVIN 100.000 0.990826 1.00461 FXN - Frataxin, mitochondrial precursor - Bos taurus (Bovine) - FXN gene Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). Taurus_UMD|evm.model.AC_000165.1.283 Q95168 ZO2_CANLF 90.290 0.951987 1.02896 TJP2 - Tight junction protein ZO-2 - Canis lupus familiaris (Dog) - TJP2 gene Plays a role in tight junctions and adherens junctions. Taurus_UMD|evm.model.AC_000165.1.284 Q15884 F1892_HUMAN 88.000 0.908907 1.09778 FAM189A2 - Protein FAM189A2 precursor - Homo sapiens (Human) - FAM189A2 gene Taurus_UMD|evm.model.AC_000165.1.285 Q02410 APBA1_HUMAN 94.418 0.997576 0.985663 APBA1 - Amyloid-beta A4 precursor protein-binding family A member 1 - Homo sapiens (Human) - APBA1 gene Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). Taurus_UMD|evm.model.AC_000165.1.286 Q7Z6K3 PTAR1_HUMAN 86.713 0.995349 1.06965 PTAR1 - Protein prenyltransferase alpha subunit repeat-containing protein 1 - Homo sapiens (Human) - PTAR1 gene cytoplasm, protein prenylation Taurus_UMD|evm.model.AC_000165.1.287 Q32L77 CI135_BOVIN 100.000 0.991416 1.00431 Protein C9orf135 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000165.1.288 Q7Z304 MAMC2_HUMAN 89.359 0.997089 1.00146 MAMDC2 - MAM domain-containing protein 2 precursor - Homo sapiens (Human) - MAMDC2 gene endoplasmic reticulum Taurus_UMD|evm.model.AC_000165.1.289 Q8IY18 SMC5_HUMAN 92.475 0.997285 1.00363 SMC5 - Structural maintenance of chromosomes protein 5 - Homo sapiens (Human) - SMC5 gene Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). Taurus_UMD|evm.model.AC_000165.1.290 P79288 KLF9_PIG 100.000 0.991837 1.0041 KLF9 - Krueppel-like factor 9 - Sus scrofa (Pig) - KLF9 gene Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation. Taurus_UMD|evm.model.AC_000165.1.292 Q9HCF6 TRPM3_HUMAN 95.588 0.994731 0.986143 TRPM3 - Transient receptor potential cation channel subfamily M member 3 - Homo sapiens (Human) - TRPM3 gene Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. In addition, forms heteromultimeric ion channels with TRPM1 which are permeable for calcium and zinc ions (PubMed:21278253). Taurus_UMD|evm.model.AC_000165.1.294 P19378 HSP7C_CRIGR 84.722 0.721649 0.150155 HSPA8 - Heat shock cognate 71 kDa protein - Cricetulus griseus (Chinese hamster) - HSPA8 gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. Interacts with VGF-derived peptide TLQP-21. Taurus_UMD|evm.model.AC_000165.1.295 Q9UHN6 CEIP2_HUMAN 90.889 0.998555 1.00072 CEMIP2 - Cell surface hyaluronidase - Homo sapiens (Human) - CEMIP2 gene Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172). Taurus_UMD|evm.model.AC_000165.1.296 Q5VST6 AB17B_HUMAN 100.000 0.99308 1.00347 ABHD17B - Alpha/beta hydrolase domain-containing protein 17B - Homo sapiens (Human) - ABHD17B gene Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913). Taurus_UMD|evm.model.AC_000165.1.297 Q96MD7 CI085_HUMAN 95.455 0.698718 0.871508 C9orf85 - Uncharacterized protein C9orf85 - Homo sapiens (Human) - C9orf85 gene Taurus_UMD|evm.model.AC_000165.1.298 Q5W0N0 CI057_HUMAN 59.302 0.490798 1.01242 C9orf57 - Uncharacterized protein C9orf57 - Homo sapiens (Human) - C9orf57 gene Taurus_UMD|evm.model.AC_000165.1.299 Q9Y2T3 GUAD_HUMAN 89.868 0.995604 1.0022 GDA - Guanine deaminase - Homo sapiens (Human) - GDA gene Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. Taurus_UMD|evm.model.AC_000165.1.300 O76080 ZFAN5_HUMAN 98.592 0.872428 1.14085 ZFAND5 - AN1-type zinc finger protein 5 - Homo sapiens (Human) - ZFAND5 gene Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. Taurus_UMD|evm.model.AC_000165.1.301 P68105 EF1A1_RABIT 94.762 0.963134 0.469697 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000165.1.302 A2Q0Z0 EF1A1_HORSE 95.536 0.917355 0.261905 EEF1A1 - Elongation factor 1-alpha 1 - Equus caballus (Horse) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000165.1.303 Q8TDI8 TMC1_HUMAN 92.593 0.995856 0.952632 TMC1 - Transmembrane channel-like protein 1 - Homo sapiens (Human) - TMC1 gene Probable ion channel required for the normal function of cochlear hair cells. Taurus_UMD|evm.model.AC_000165.1.304 P48644 AL1A1_BOVIN 100.000 0.996016 1.002 ALDH1A1 - Retinal dehydrogenase 1 - Bos taurus (Bovine) - ALDH1A1 gene Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal. May have a broader specificity and oxidize other aldehydes in vivo. Taurus_UMD|evm.model.AC_000165.1.305 Q92116 CP1A1_STECH 52.000 0.142857 0.658349 cyp1a1 - Cytochrome P450 1A1 - Stenotomus chrysops (Scup) - cyp1a1 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Taurus_UMD|evm.model.AC_000165.1.306 P46193 ANXA1_BOVIN 95.087 0.994048 0.971098 ANXA1 - Annexin A1 - Bos taurus (Bovine) - ANXA1 gene Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T-cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (By similarity). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). Taurus_UMD|evm.model.AC_000165.1.307 Q13309 SKP2_HUMAN 90.698 0.971591 0.415094 SKP2 - S-phase kinase-associated protein 2 - Homo sapiens (Human) - SKP2 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:17962192, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Taurus_UMD|evm.model.AC_000165.1.310 Q92753 RORB_HUMAN 89.362 0.995316 0.908511 RORB - Nuclear receptor ROR-beta - Homo sapiens (Human) - RORB gene Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity). Taurus_UMD|evm.model.AC_000165.1.312 Q9BX84 TRPM6_HUMAN 83.627 0.999017 1.00643 TRPM6 - Transient receptor potential cation channel subfamily M member 6 - Homo sapiens (Human) - TRPM6 gene Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. Taurus_UMD|evm.model.AC_000165.1.313 Q8IXQ3 CI040_HUMAN 72.308 0.989796 1.01031 C9orf40 - Uncharacterized protein C9orf40 - Homo sapiens (Human) - C9orf40 gene Taurus_UMD|evm.model.AC_000165.1.314 Q8N4J0 CARME_HUMAN 96.154 0.85567 1.18582 CARNMT1 - Carnosine N-methyltransferase - Homo sapiens (Human) - CARNMT1 gene N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His). Taurus_UMD|evm.model.AC_000165.1.315 Q9NWW6 NRK1_HUMAN 85.427 0.99 1.00503 NMRK1 - Nicotinamide riboside kinase 1 - Homo sapiens (Human) - NMRK1 gene Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine. Taurus_UMD|evm.model.AC_000165.1.316 Q8MJ50 OSTF1_BOVIN 100.000 0.990698 1.00467 OSTF1 - Osteoclast-stimulating factor 1 - Bos taurus (Bovine) - OSTF1 gene Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity. Taurus_UMD|evm.model.AC_000165.1.317 P63159 HMGB1_RAT 59.732 0.980952 0.488372 Hmgb1 - High mobility group protein B1 - Rattus norvegicus (Rat) - Hmgb1 gene Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide (PubMed:11154118). Bound to RAGE mediates signaling for neuronal outgrowth (PubMed:1885601, PubMed:2461949, PubMed:7592757, PubMed:12183440). May play a role in accumulation of expanded polyglutamine (polyQ) proteins. Taurus_UMD|evm.model.AC_000165.1.318 P41413 PCSK5_RAT 80.217 0.980877 0.491432 Pcsk5 - Proprotein convertase subtilisin/kexin type 5 precursor - Rattus norvegicus (Rat) - Pcsk5 gene Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors. Taurus_UMD|evm.model.AC_000165.1.319 Q92824 PCSK5_HUMAN 78.136 0.986555 0.319892 PCSK5 - Proprotein convertase subtilisin/kexin type 5 precursor - Homo sapiens (Human) - PCSK5 gene Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. Taurus_UMD|evm.model.AC_000165.1.320 Q969G6 RIFK_HUMAN 94.839 0.987179 1.00645 RFK - Riboflavin kinase - Homo sapiens (Human) - RFK gene Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase. Taurus_UMD|evm.model.AC_000165.1.321 Q10126 YSM6_CAEEL 26.522 0.893162 0.83871 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000165.1.323 Q92180 GCNT1_BOVIN 99.533 0.995338 1.00468 GCNT1 - Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase - Bos taurus (Bovine) - GCNT1 gene Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes. Taurus_UMD|evm.model.AC_000165.1.324 Q5R4Q8 PRUN2_PONAB 91.045 0.108442 9.5356 PRUNE2 - Protein prune homolog 2 - Pongo abelii (Sumatran orangutan) - PRUNE2 gene May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. Taurus_UMD|evm.model.AC_000165.1.325 Q64733 FOXB2_MOUSE 100.000 0.233853 1.04907 Foxb2 - Forkhead box protein B2 - Mus musculus (Mouse) - Foxb2 gene Transcription factor. Taurus_UMD|evm.model.AC_000165.1.326 Q96RL7 VP13A_HUMAN 84.692 0.437775 0.430372 VPS13A - Vacuolar protein sorting-associated protein 13A - Homo sapiens (Human) - VPS13A gene Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria (PubMed:30741634). Negatively regulates lipid droplet size and motility (PubMed:30741634). Required for efficient lysosomal protein degradation (PubMed:30709847). Taurus_UMD|evm.model.AC_000165.1.327 Q5H8C4 VP13A_MOUSE 93.636 0.981982 0.03506 Vps13a - Vacuolar protein sorting-associated protein 13A - Mus musculus (Mouse) - Vps13a gene Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria (By similarity). Negatively regulates lipid droplet size and motility (By similarity). Required for efficient lysosomal protein degradation (By similarity). Taurus_UMD|evm.model.AC_000165.1.328 P38408 GNA14_BOVIN 100.000 0.994382 1.00282 GNA14 - Guanine nucleotide-binding protein subunit alpha-14 - Bos taurus (Bovine) - GNA14 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Taurus_UMD|evm.model.AC_000165.1.329 Q2PKF4 GNAQ_PIG 100.000 0.992095 0.704735 GNAQ - Guanine nucleotide-binding protein G(q) subunit alpha - Sus scrofa (Pig) - GNAQ gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). Taurus_UMD|evm.model.AC_000165.1.330 Q2PKF4 GNAQ_PIG 98.413 0.72093 0.239554 GNAQ - Guanine nucleotide-binding protein G(q) subunit alpha - Sus scrofa (Pig) - GNAQ gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). Taurus_UMD|evm.model.AC_000165.1.331 P82471 GNAQ_RAT 100.000 0.411215 0.29805 Gnaq - Guanine nucleotide-binding protein G(q) subunit alpha - Rattus norvegicus (Rat) - Gnaq gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). Taurus_UMD|evm.model.AC_000165.1.332 Q5JTW2 CEP78_HUMAN 83.144 0.873606 1.17126 CEP78 - Centrosomal protein of 78 kDa - Homo sapiens (Human) - CEP78 gene May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). May play a role in cilium biogenesis (PubMed:27588451). Taurus_UMD|evm.model.AC_000165.1.333 Q9Y617 SERC_HUMAN 92.703 0.840547 1.18649 PSAT1 - Phosphoserine aminotransferase - Homo sapiens (Human) - PSAT1 gene Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. Taurus_UMD|evm.model.AC_000165.1.334 P62828 RAN_RAT 92.130 0.986239 1.00926 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Taurus_UMD|evm.model.AC_000165.1.335 Q04727 TLE4_HUMAN 99.803 0.71773 0.912031 TLE4 - Transducin-like enhancer protein 4 - Homo sapiens (Human) - TLE4 gene Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Taurus_UMD|evm.model.AC_000165.1.337 P52591 PO121_RAT 39.456 0.162946 0.747289 Pom121 - Nuclear envelope pore membrane protein POM 121 - Rattus norvegicus (Rat) - Pom121 gene Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). Taurus_UMD|evm.model.AC_000165.1.338 Q1LZD0 AA2BR_BOVIN 73.469 0.423423 0.334337 ADORA2B - Adenosine receptor A2b - Bos taurus (Bovine) - ADORA2B gene Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Taurus_UMD|evm.model.AC_000165.1.339 Q04724 TLE1_HUMAN 75.455 0.996904 0.838961 TLE1 - Transducin-like enhancer protein 1 - Homo sapiens (Human) - TLE1 gene Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. Taurus_UMD|evm.model.AC_000165.1.340 Q62441 TLE4_MOUSE 98.611 0.788889 0.116429 Tle4 - Transducin-like enhancer protein 4 - Mus musculus (Mouse) - Tle4 gene Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression. Taurus_UMD|evm.model.AC_000165.1.341 Q6ZQQ2 S31D1_HUMAN 53.807 0.650859 0.923223 SPATA31D1 - Spermatogenesis-associated protein 31D1 - Homo sapiens (Human) - SPATA31D1 gene May play a role in spermatogenesis. Taurus_UMD|evm.model.AC_000165.1.342 P0C874 S31D3_HUMAN 42.137 0.557432 1.61396 SPATA31D3 - Spermatogenesis-associated protein 31D3 - Homo sapiens (Human) - SPATA31D3 gene May play a role in spermatogenesis. Taurus_UMD|evm.model.AC_000165.1.344 Q63HN1 F205B_HUMAN 66.369 0.417854 2.39748 FAM205BP - Putative protein FAM205B - Homo sapiens (Human) - FAM205BP gene Taurus_UMD|evm.model.AC_000165.1.345 Q32LN6 F205C_BOVIN 100.000 0.99511 1.00245 FAM205C - Protein FAM205C - Bos taurus (Bovine) - FAM205C gene Taurus_UMD|evm.model.AC_000165.1.346 Q9UPV7 PHF24_HUMAN 92.500 0.995012 1.0025 PHF24 - PHD finger protein 24 - Homo sapiens (Human) - PHF24 gene Taurus_UMD|evm.model.AC_000165.1.347 Q5BIP8 DNJB5_BOVIN 100.000 0.816471 1.22126 DNAJB5 - DnaJ homolog subfamily B member 5 - Bos taurus (Bovine) - DNAJB5 gene cytosol, chaperone binding, unfolded protein binding, chaperone cofactor-dependent protein refolding Taurus_UMD|evm.model.AC_000165.1.349 Q5VYM1 CI131_HUMAN 52.659 0.618197 1.14087 C9orf131 - Uncharacterized protein C9orf131 - Homo sapiens (Human) - C9orf131 gene Taurus_UMD|evm.model.AC_000165.1.350 Q3ZBT1 TERA_BOVIN 99.876 0.997522 1.00124 VCP - Transitional endoplasmic reticulum ATPase - Bos taurus (Bovine) - VCP gene Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Plays a role in the regulation of stress granules (SGs) clearance process upon arsenite-induced response (By similarity). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis. Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex. Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation. Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy. Acts as a negative regulator of type I interferon production by interacting with DDX58/RIG-I: interaction takes place when DDX58/RIG-I is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of DDX58/RIG-I. May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation. May more particularly play a role in caveolins sorting in cells. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Taurus_UMD|evm.model.AC_000165.1.351 O15287 FANCG_HUMAN 80.165 0.969502 1.00161 FANCG - Fanconi anemia group G protein - Homo sapiens (Human) - FANCG gene DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. Taurus_UMD|evm.model.AC_000165.1.352 Q8TEQ8 PIGO_HUMAN 82.277 0.932189 1.06979 PIGO - GPI ethanolamine phosphate transferase 3 - Homo sapiens (Human) - PIGO gene Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond. Taurus_UMD|evm.model.AC_000165.1.353 Q32LL2 STML2_BOVIN 99.719 0.994398 1.00281 STOML2 - Stomatin-like protein 2, mitochondrial precursor - Bos taurus (Bovine) - STOML2 gene Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation (By similarity). Taurus_UMD|evm.model.AC_000165.1.354 Q5BIM2 F214B_BOVIN 100.000 0.85103 1.17286 FAM214B - Protein FAM214B - Bos taurus (Bovine) - FAM214B gene Taurus_UMD|evm.model.AC_000165.1.355 O14795 UN13B_HUMAN 95.726 0.998744 1.00063 UNC13B - Protein unc-13 homolog B - Homo sapiens (Human) - UNC13B gene Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). Taurus_UMD|evm.model.AC_000165.1.356 A3FIN4 AT8B5_MOUSE 77.386 0.994007 0.98732 Atp8b5 - Phospholipid-transporting ATPase FetA - Mus musculus (Mouse) - Atp8b5 gene P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in phospholid transport across membranes and in acrosome formation. Taurus_UMD|evm.model.AC_000165.1.357 Q8N2Y8 RUSC2_HUMAN 89.074 0.983455 0.996702 RUSC2 - Iporin - Homo sapiens (Human) - RUSC2 gene cytoplasmic vesicle, extracellular exosome, small GTPase binding Taurus_UMD|evm.model.AC_000165.1.358 Q2TBR5 F166B_BOVIN 100.000 0.992727 1.00365 FAM166B - Protein FAM166B - Bos taurus (Bovine) - FAM166B gene Taurus_UMD|evm.model.AC_000165.1.359 Q15569 TESK1_HUMAN 94.257 0.936609 1.00799 TESK1 - Dual specificity testis-specific protein kinase 1 - Homo sapiens (Human) - TESK1 gene Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). Taurus_UMD|evm.model.AC_000165.1.360 P21854 CD72_HUMAN 60.109 0.977839 1.00557 CD72 - B-cell differentiation antigen CD72 - Homo sapiens (Human) - CD72 gene Plays a role in B-cell proliferation and differentiation. Taurus_UMD|evm.model.AC_000165.1.361 Q9Y3P8 SIT1_HUMAN 78.378 0.989247 0.94898 SIT1 - Signaling threshold-regulating transmembrane adapter 1 precursor - Homo sapiens (Human) - SIT1 gene Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells. Taurus_UMD|evm.model.AC_000165.1.362 Q2NL23 CC107_BOVIN 100.000 0.992278 1.00388 CCDC107 - Coiled-coil domain-containing protein 107 precursor - Bos taurus (Bovine) - CCDC107 gene Taurus_UMD|evm.model.AC_000165.1.363 Q0P5E3 ARG39_BOVIN 100.000 0.994048 1.00299 ARHGEF39 - Rho guanine nucleotide exchange factor 39 - Bos taurus (Bovine) - ARHGEF39 gene Promotes cell proliferation. Taurus_UMD|evm.model.AC_000165.1.364 Q16790 CAH9_HUMAN 80.694 0.843691 1.15686 CA9 - Carbonic anhydrase 9 precursor - Homo sapiens (Human) - CA9 gene Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. Taurus_UMD|evm.model.AC_000165.1.365 P58775 TPM2_RAT 92.606 0.992982 1.00352 Tpm2 - Tropomyosin beta chain - Rattus norvegicus (Rat) - Tpm2 gene Binds to actin filaments in muscle and non-muscle cells (PubMed:7568216, PubMed:22812662). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:22812662). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity). Taurus_UMD|evm.model.AC_000165.1.366 Q9Y490 TLN1_HUMAN 98.898 0.999213 1.00039 TLN1 - Talin-1 - Homo sapiens (Human) - TLN1 gene Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity). Taurus_UMD|evm.model.AC_000165.1.367 Q8SQ19 CREB3_BOVIN 100.000 0.99458 1.00272 CREB3 - Cyclic AMP-responsive element-binding protein 3 - Bos taurus (Bovine) - CREB3 gene Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription. Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death. Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Associates with chromatin to the HERPUD1 promoter. Also induces transcriptional activation of chemokine receptors. Functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Also decreases the acetylation level of histone H4. Does not promote the chemotactic activity of leukocyte cells. Taurus_UMD|evm.model.AC_000165.1.368 Q9HCG7 GBA2_HUMAN 87.717 0.997824 0.99137 GBA2 - Non-lysosomal glucosylceramidase - Homo sapiens (Human) - GBA2 gene Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide (PubMed:17105727, PubMed:30308956). Glucosylceramides are membrane glycosphingolipids that have a wide intracellular distribution (By similarity). They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties (By similarity). Also involved in the transglucosylation of cholesterol, transferring glucose from glucosylceramides, thereby modifying its water solubility and biological properties (By similarity). Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide (By similarity). Finally, may also play a role in the metabolism of bile acids (PubMed:11489889, PubMed:9111029, PubMed:17080196). It is able to hydrolyze bile acid 3-O-glucosides but also to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity (PubMed:11489889, PubMed:9111029, PubMed:17080196). However, the relevance of both activities is unclear in vivo (By similarity). Taurus_UMD|evm.model.AC_000165.1.369 Q2T9P3 RGP1_BOVIN 99.728 0.936224 0.994924 RGP1 - RAB6A-GEF complex partner protein 2 - Bos taurus (Bovine) - RGP1 gene The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Taurus_UMD|evm.model.AC_000165.1.370 Q1L6U9 MSMP_HUMAN 91.367 0.985714 1.00719 MSMP - Prostate-associated microseminoprotein precursor - Homo sapiens (Human) - MSMP gene Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:24442440). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:24442440). Exhibits a chemotactic activity for monocytes and lymphocytes but not neutrophils (PubMed:24442440). Taurus_UMD|evm.model.AC_000165.1.371 P46197 ANPRB_BOVIN 100.000 0.97893 0.589303 NPR2 - Atrial natriuretic peptide receptor 2 precursor - Bos taurus (Bovine) - NPR2 gene Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. Taurus_UMD|evm.model.AC_000165.1.372 P46197 ANPRB_BOVIN 98.595 0.986079 0.411652 NPR2 - Atrial natriuretic peptide receptor 2 precursor - Bos taurus (Bovine) - NPR2 gene Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. Taurus_UMD|evm.model.AC_000165.1.373 Q99932 SPAG8_HUMAN 58.886 0.991848 0.758763 SPAG8 - Sperm-associated antigen 8 - Homo sapiens (Human) - SPAG8 gene Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (PubMed:19548270). May play a role in fertility and microtubule formation through interaction with RANBP9 (PubMed:10500252). Taurus_UMD|evm.model.AC_000165.1.374 Q8SQ21 HINT2_BOVIN 100.000 0.987805 1.00613 HINT2 - Histidine triad nucleotide-binding protein 2, mitochondrial precursor - Bos taurus (Bovine) - HINT2 gene Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity (By similarity). Taurus_UMD|evm.model.AC_000165.1.375 A6H8Z2 F221B_HUMAN 63.196 0.877419 1.15672 FAM221B - Protein FAM221B - Homo sapiens (Human) - FAM221B gene Taurus_UMD|evm.model.AC_000165.1.376 A6QLK4 TMM8B_BOVIN 100.000 0.505908 1.97246 TMEM8B - Transmembrane protein 8B - Bos taurus (Bovine) - TMEM8B gene May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion (By similarity). Taurus_UMD|evm.model.AC_000165.1.377 Q6UXD1 HRCT1_HUMAN 62.069 0.747826 1 HRCT1 - Histidine-rich carboxyl terminus protein 1 - Homo sapiens (Human) - HRCT1 gene Taurus_UMD|evm.model.AC_000165.1.378 A0A1B0GVQ0 SPAR_HUMAN 86.154 0.463768 1.53333 SPAAR - Small regulatory polypeptide of amino acid response - Homo sapiens (Human) - SPAAR gene Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels and amino acids (PubMed:28024296). Negatively regulates mTORC1 activation by inhibiting recruitment of mTORC1 to lysosomes upon stimulation with amino acids: acts by promoting the formation of a tightly bound supercomplex composed of the lysosomal V-ATPase, Ragulator and Rag GTPases, preventing recruitment of mTORC1 (PubMed:28024296). Acts as a regulator of muscle regeneration following injury by regulating mTORC1 activation (By similarity). Taurus_UMD|evm.model.AC_000165.1.379 O95980 RECK_HUMAN 93.210 0.997945 1.00206 RECK - Reversion-inducing cysteine-rich protein with Kazal motifs precursor - Homo sapiens (Human) - RECK gene Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:9789069, PubMed:18194466). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069). Taurus_UMD|evm.model.AC_000165.1.380 Q9H4G4 GAPR1_HUMAN 96.104 0.987097 1.00649 GLIPR2 - Golgi-associated plant pathogenesis-related protein 1 - Homo sapiens (Human) - GLIPR2 gene extracellular exosome, extracellular space, Golgi membrane, protein homodimerization activity, positive regulation of epithelial cell migration, positive regulation of epithelial to mesenchymal transition, positive regulation of ERK1 and ERK2 cascade Taurus_UMD|evm.model.AC_000165.1.381 Q28068 CALI_BOVIN 100.000 0.996604 1.0017 CCIN - Calicin - Bos taurus (Bovine) - CCIN gene Possible morphogenic cytoskeletal element in spermiogenic differentiation. Taurus_UMD|evm.model.AC_000165.1.382 P04973 CLCA_BOVIN 100.000 0.991803 1.00412 CLTA - Clathrin light chain A - Bos taurus (Bovine) - CLTA gene Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (By similarity). Taurus_UMD|evm.model.AC_000165.1.383 Q9Y223 GLCNE_HUMAN 98.338 0.997234 1.00139 GNE - Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase - Homo sapiens (Human) - GNE gene Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. Taurus_UMD|evm.model.AC_000165.1.384 Q9H0F5 RNF38_HUMAN 98.633 0.944547 1.05049 RNF38 - E3 ubiquitin-protein ligase RNF38 - Homo sapiens (Human) - RNF38 gene Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme. Taurus_UMD|evm.model.AC_000165.1.385 Q14680 MELK_HUMAN 89.555 0.996928 1 MELK - Maternal embryonic leucine zipper kinase - Homo sapiens (Human) - MELK gene Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. Taurus_UMD|evm.model.AC_000165.1.386 Q02650 PAX5_MOUSE 97.340 0.956633 1.00256 Pax5 - Paired box protein Pax-5 - Mus musculus (Mouse) - Pax5 gene Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:9042861). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:16546096). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:9042861, PubMed:16546096). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (By similarity). Taurus_UMD|evm.model.AC_000165.1.387 Q2KIN0 ZCHC7_BOVIN 99.634 0.996344 1.00183 ZCCHC7 - Zinc finger CCHC domain-containing protein 7 - Bos taurus (Bovine) - ZCCHC7 gene Taurus_UMD|evm.model.AC_000165.1.388 P62752 RL23A_RAT 50.442 0.59542 0.839744 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000165.1.389 Q9UBQ7 GRHPR_HUMAN 88.720 0.993921 1.00305 GRHPR - Glyoxylate reductase/hydroxypyruvate reductase - Homo sapiens (Human) - GRHPR gene Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. Taurus_UMD|evm.model.AC_000165.1.390 O15062 ZBTB5_HUMAN 95.273 0.946704 1.05318 ZBTB5 - Zinc finger and BTB domain-containing protein 5 - Homo sapiens (Human) - ZBTB5 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000165.1.391 Q9GZS1 RPA49_HUMAN 87.112 0.995238 1.00239 POLR1E - DNA-directed RNA polymerase I subunit RPA49 - Homo sapiens (Human) - POLR1E gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors (PubMed:24207024). Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (PubMed:24207024). Taurus_UMD|evm.model.AC_000165.1.392 Q9UK96 FBX10_HUMAN 90.063 0.962475 1.03138 FBXO10 - F-box only protein 10 - Homo sapiens (Human) - FBXO10 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. Taurus_UMD|evm.model.AC_000165.1.395 Q5SYB0 FRPD1_HUMAN 81.132 0.998741 1.00634 FRMPD1 - FERM and PDZ domain-containing protein 1 - Homo sapiens (Human) - FRMPD1 gene Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1. Taurus_UMD|evm.model.AC_000165.1.396 Q08DP1 TM10B_BOVIN 83.861 0.992481 0.841772 TRMT10B - tRNA methyltransferase 10 homolog B - Bos taurus (Bovine) - TRMT10B gene S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs. Taurus_UMD|evm.model.AC_000165.1.397 Q3T0E1 EXOS3_BOVIN 100.000 0.992754 1.00364 EXOSC3 - Exosome complex component RRP40 - Bos taurus (Bovine) - EXOSC3 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5 (By similarity). Taurus_UMD|evm.model.AC_000165.1.399 Q5QP82 DCA10_HUMAN 95.273 0.59436 0.824687 DCAF10 - DDB1- and CUL4-associated factor 10 - Homo sapiens (Human) - DCAF10 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Taurus_UMD|evm.model.AC_000165.1.400 Q9H1U9 S2551_HUMAN 93.603 0.993289 1.00337 SLC25A51 - Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 - Homo sapiens (Human) - SLC25A51 gene Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria (PubMed:32906142). Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration (PubMed:32906142). Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria (PubMed:32906142). Taurus_UMD|evm.model.AC_000165.1.401 Q15464 SHB_HUMAN 98.148 0.449082 1.17682 SHB - SH2 domain-containing adapter protein B - Homo sapiens (Human) - SHB gene Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. Taurus_UMD|evm.model.AC_000165.1.402 O15347 HMGB3_HUMAN 80.357 0.72093 1.075 HMGB3 - High mobility group protein B3 - Homo sapiens (Human) - HMGB3 gene Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). Taurus_UMD|evm.model.AC_000165.1.403 P83917 CBX1_MOUSE 100.000 0.989247 1.00541 Cbx1 - Chromobox protein homolog 1 - Mus musculus (Mouse) - Cbx1 gene Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Taurus_UMD|evm.model.AC_000165.1.404 P52476 AL1B1_BOVIN 100.000 0.962264 1.03718 ALDH1B1 - Aldehyde dehydrogenase X, mitochondrial precursor - Bos taurus (Bovine) - ALDH1B1 gene ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. In the cornea, this enzyme may help in the absorption of the damaging UV-B, as well as in the detoxification of the UV-induced peroxidic aldehydes. Taurus_UMD|evm.model.AC_000165.1.405 A5PKD8 IBPL1_BOVIN 100.000 0.784483 1.27007 IGFBPL1 - Insulin-like growth factor-binding protein-like 1 precursor - Bos taurus (Bovine) - IGFBPL1 gene IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). Taurus_UMD|evm.model.AC_000165.1.406 Q9DBN1 STR6L_MOUSE 79.516 0.995153 0.996779 Stra6l - Stimulated by retinoic acid gene 6 protein-like - Mus musculus (Mouse) - Stra6l gene Acts as a high-affinity cell-surface receptor for retinol-binding protein RBP4 and mediates RBP4-dependent retinol uptake in the liver. Taurus_UMD|evm.model.AC_000165.1.407 Q9P1Z9 CC180_HUMAN 69.615 0.998769 0.95532 CCDC180 - Coiled-coil domain-containing protein 180 - Homo sapiens (Human) - CCDC180 gene extracellular exosome Taurus_UMD|evm.model.AC_000165.1.408 P54252 ATX3_HUMAN 83.810 0.611765 0.470914 ATXN3 - Ataxin-3 - Homo sapiens (Human) - ATXN3 gene Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). Taurus_UMD|evm.model.AC_000165.1.409 A6QLE1 TDRD7_BOVIN 100.000 0.99818 1.00091 TDRD7 - Tudor domain-containing protein 7 - Bos taurus (Bovine) - TDRD7 gene Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis (By similarity). Taurus_UMD|evm.model.AC_000165.1.410 A0JNC0 TMOD1_BOVIN 96.629 0.836585 1.14206 TMOD1 - Tropomodulin-1 - Bos taurus (Bovine) - TMOD1 gene Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus (By similarity). Taurus_UMD|evm.model.AC_000165.1.411 Q5T7W7 TSTD2_HUMAN 84.221 0.978599 0.996124 TSTD2 - Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 - Homo sapiens (Human) - TSTD2 gene Taurus_UMD|evm.model.AC_000165.1.412 Q09161 NCBP1_HUMAN 99.114 0.997472 1.00127 NCBP1 - Nuclear cap-binding protein subunit 1 - Homo sapiens (Human) - NCBP1 gene Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability (PubMed:26382858). Taurus_UMD|evm.model.AC_000165.1.413 P23025 XPA_HUMAN 91.575 0.992701 1.00366 XPA - DNA repair protein complementing XP-A cells - Homo sapiens (Human) - XPA gene Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. Taurus_UMD|evm.model.AC_000165.1.414 O00358 FOXE1_HUMAN 91.200 0.994652 1.00268 FOXE1 - Forkhead box protein E1 - Homo sapiens (Human) - FOXE1 gene Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression. Taurus_UMD|evm.model.AC_000165.1.415 Q9BU70 TRMO_HUMAN 74.944 0.995423 0.99093 TRMO - tRNA (adenine(37)-N6)-methyltransferase - Homo sapiens (Human) - TRMO gene S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU) (PubMed:25063302). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity). Taurus_UMD|evm.model.AC_000165.1.416 Q32L62 HEMGN_BOVIN 99.776 0.995536 1.00224 HEMGN - Hemogen - Bos taurus (Bovine) - HEMGN gene Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity). Taurus_UMD|evm.model.AC_000165.1.417 Q3SZC6 AN32B_BOVIN 96.875 0.700441 0.869732 ANP32B - Acidic leucine-rich nuclear phosphoprotein 32 family member B - Bos taurus (Bovine) - ANP32B gene Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription. Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis. Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes. Plays also an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (By similarity). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000165.1.418 Q9NR45 SIAS_HUMAN 96.657 0.994444 1.00279 NANS - Sialic acid synthase - Homo sapiens (Human) - NANS gene Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Taurus_UMD|evm.model.AC_000165.1.419 Q14142 TRI14_HUMAN 91.667 0.306792 0.966063 TRIM14 - Tripartite motif-containing protein 14 - Homo sapiens (Human) - TRIM14 gene Plays an essential role in the innate immune defense against viruses and bacteria (PubMed:30150992, PubMed:32404352). Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways (PubMed:24379373). Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593). Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression (PubMed:32404352). Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000165.1.420 Q32LP9 COR2A_BOVIN 100.000 0.996198 1.0019 CORO2A - Coronin-2A - Bos taurus (Bovine) - CORO2A gene actin filament binding Taurus_UMD|evm.model.AC_000165.1.421 A6QP29 TBD2A_BOVIN 100.000 0.99784 1.00108 TBC1D2 - TBC1 domain family member 2A - Bos taurus (Bovine) - TBC1D2 gene May act as a GTPase-activating protein for Rab family protein(s). Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and further inhibition of cadherin degradation (By similarity). Taurus_UMD|evm.model.AC_000165.1.422 O75899 GABR2_HUMAN 100.000 0.149338 0.562168 GABBR2 - Gamma-aminobutyric acid type B receptor subunit 2 precursor - Homo sapiens (Human) - GABBR2 gene Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:9872744, PubMed:10906333, PubMed:10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Taurus_UMD|evm.model.AC_000165.1.423 Q68DC2 ANKS6_HUMAN 91.743 0.996536 0.994259 ANKS6 - Ankyrin repeat and SAM domain-containing protein 6 - Homo sapiens (Human) - ANKS6 gene Required for renal function. Taurus_UMD|evm.model.AC_000165.1.424 Q8BGT9 GLT12_MOUSE 81.250 0.642276 0.213542 Galnt12 - Polypeptide N-acetylgalactosaminyltransferase 12 - Mus musculus (Mouse) - Galnt12 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs (By similarity). Taurus_UMD|evm.model.AC_000165.1.425 Q8IXK2 GLT12_HUMAN 89.059 0.964059 0.814114 GALNT12 - Polypeptide N-acetylgalactosaminyltransferase 12 - Homo sapiens (Human) - GALNT12 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. Taurus_UMD|evm.model.AC_000165.1.426 P39059 COFA1_HUMAN 80.546 0.998543 0.989193 COL15A1 - Collagen alpha-1(XV) chain precursor - Homo sapiens (Human) - COL15A1 gene Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. Taurus_UMD|evm.model.AC_000165.1.427 O46680 TGFR1_BOVIN 99.205 0.996032 1.01002 TGFBR1 - TGF-beta receptor type-1 precursor - Bos taurus (Bovine) - TGFBR1 gene Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation (By similarity). Taurus_UMD|evm.model.AC_000165.1.428 Q9H553 ALG2_HUMAN 89.183 0.995204 1.0024 ALG2 - Alpha-1,3/1,6-mannosyltransferase ALG2 - Homo sapiens (Human) - ALG2 gene Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Taurus_UMD|evm.model.AC_000165.1.431 Q9GMB0 RPN1_PIG 85.362 0.996716 1.00164 RPN1 - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor - Sus scrofa (Pig) - RPN1 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (Probable). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Taurus_UMD|evm.model.AC_000165.1.432 Q92570 NR4A3_HUMAN 91.680 0.823834 1.23323 NR4A3 - Nuclear receptor subfamily 4 group A member 3 - Homo sapiens (Human) - NR4A3 gene Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Plays also a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Plays also a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity). Taurus_UMD|evm.model.AC_000165.1.433 Q5E9Y2 STX17_BOVIN 100.000 0.993399 1.00331 STX17 - Syntaxin-17 - Bos taurus (Bovine) - STX17 gene SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (By similarity). Taurus_UMD|evm.model.AC_000165.1.434 Q3T0L2 ERP44_BOVIN 100.000 0.995086 1.00246 ERP44 - Endoplasmic reticulum resident protein 44 precursor - Bos taurus (Bovine) - ERP44 gene Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum (By similarity). Taurus_UMD|evm.model.AC_000165.1.435 Q6JAN1 INVS_CANLF 89.054 0.988062 1.0074 INVS - Inversin - Canis lupus familiaris (Dog) - INVS gene Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Taurus_UMD|evm.model.AC_000165.1.436 Q9NXF1 TEX10_HUMAN 92.620 0.997863 1.00753 TEX10 - Testis-expressed protein 10 - Homo sapiens (Human) - TEX10 gene Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). Taurus_UMD|evm.model.AC_000165.1.437 A8MTI9 PRS47_HUMAN 55.247 0.79056 0.904 PRSS47 - Putative serine protease 47 precursor - Homo sapiens (Human) - PRSS47 gene extracellular space, serine-type endopeptidase activity, proteolysis Taurus_UMD|evm.model.AC_000165.1.438 E9QAF0 SPT31_MOUSE 58.696 0.0246981 1.79684 Spata31 - Spermatogenesis-associated protein 31 - Mus musculus (Mouse) - Spata31 gene May play a role in spermatogenesis. Taurus_UMD|evm.model.AC_000165.1.439 A8MTI9 PRS47_HUMAN 54.508 0.706061 0.88 PRSS47 - Putative serine protease 47 precursor - Homo sapiens (Human) - PRSS47 gene extracellular space, serine-type endopeptidase activity, proteolysis Taurus_UMD|evm.model.AC_000165.1.440 Q9NXF1 TEX10_HUMAN 85.801 0.716484 0.489774 TEX10 - Testis-expressed protein 10 - Homo sapiens (Human) - TEX10 gene Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). Taurus_UMD|evm.model.AC_000165.1.441 A8MTI9 PRS47_HUMAN 45.817 0.879245 0.706667 PRSS47 - Putative serine protease 47 precursor - Homo sapiens (Human) - PRSS47 gene extracellular space, serine-type endopeptidase activity, proteolysis Taurus_UMD|evm.model.AC_000165.1.442 P79103 RS4_BOVIN 96.198 0.992424 1.0038 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000165.1.443 Q9BZ76 CNTP3_HUMAN 73.391 0.409938 0.875 CNTNAP3 - Contactin-associated protein-like 3 precursor - Homo sapiens (Human) - CNTNAP3 gene integral component of membrane, cell recognition Taurus_UMD|evm.model.AC_000165.1.444 P0DKV0 S31C1_HUMAN 39.011 0.0895028 1.52357 SPATA31C1 - Putative spermatogenesis-associated protein 31C1 - Homo sapiens (Human) - SPATA31C1 gene May play a role in spermatogenesis. Taurus_UMD|evm.model.AC_000165.1.445 Q8TF47 ZFP90_HUMAN 76.190 0.362832 0.177673 ZFP90 - Zinc finger protein 90 homolog - Homo sapiens (Human) - ZFP90 gene Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes. Taurus_UMD|evm.model.AC_000165.1.447 Q58DT1 RL7_BOVIN 88.068 0.988095 0.677419 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Taurus_UMD|evm.model.AC_000165.1.448 P54219 VMAT1_HUMAN 80.000 0.996 0.952381 SLC18A1 - Chromaffin granule amine transporter - Homo sapiens (Human) - SLC18A1 gene Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells. Taurus_UMD|evm.model.AC_000165.1.449 P31408 VATB2_BOVIN 100.000 0.996094 1.00196 ATP6V1B2 - V-type proton ATPase subunit B, brain isoform - Bos taurus (Bovine) - ATP6V1B2 gene Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity). Taurus_UMD|evm.model.AC_000165.1.450 Q9Y250 LZTS1_HUMAN 90.349 0.996644 1 LZTS1 - Leucine zipper putative tumor suppressor 1 - Homo sapiens (Human) - LZTS1 gene Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. Taurus_UMD|evm.model.AC_000165.1.451 P15880 RS2_HUMAN 71.739 0.986842 0.518771 RPS2 - 40S ribosomal protein S2 - Homo sapiens (Human) - RPS2 gene cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleoplasm, nucleus, cadherin binding, enzyme binding Taurus_UMD|evm.model.AC_000165.1.452 O18789 RS2_BOVIN 88.372 0.403846 0.354949 RPS2 - 40S ribosomal protein S2 - Bos taurus (Bovine) - RPS2 gene cytosolic small ribosomal subunit, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000165.1.453 Q5E9U0 SP2_BOVIN 94.719 0.996528 0.939641 SP2 - Transcription factor Sp2 - Bos taurus (Bovine) - SP2 gene Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Taurus_UMD|evm.model.AC_000165.1.454 P84089 ERH_MOUSE 75.904 0.78125 0.923077 Erh - Enhancer of rudimentary homolog - Mus musculus (Mouse) - Erh gene May have a role in the cell cycle. Taurus_UMD|evm.model.AC_000165.1.456 Q5E9X0 GFRA2_BOVIN 92.793 0.969298 0.491379 GFRA2 - GDNF family receptor alpha-2 precursor - Bos taurus (Bovine) - GFRA2 gene Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor (By similarity). Taurus_UMD|evm.model.AC_000165.1.457 Q5E9X0 GFRA2_BOVIN 100.000 0.992481 0.573276 GFRA2 - GDNF family receptor alpha-2 precursor - Bos taurus (Bovine) - GFRA2 gene Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor (By similarity). Taurus_UMD|evm.model.AC_000165.1.459 A7MBB8 DOK2_BOVIN 100.000 0.995169 1.00242 DOK2 - Docking protein 2 - Bos taurus (Bovine) - DOK2 gene DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). Taurus_UMD|evm.model.AC_000165.1.460 Q9UIA9 XPO7_HUMAN 98.449 0.982944 1.02484 XPO7 - Exportin-7 - Homo sapiens (Human) - XPO7 gene Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Taurus_UMD|evm.model.AC_000165.1.461 O60258 FGF17_HUMAN 97.037 0.349869 1.77315 FGF17 - Fibroblast growth factor 17 precursor - Homo sapiens (Human) - FGF17 gene Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. Taurus_UMD|evm.model.AC_000165.1.463 Q08DM1 DEMA_BOVIN 99.754 0.995074 1 DMTN - Dematin - Bos taurus (Bovine) - DMTN gene Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation (By similarity). Taurus_UMD|evm.model.AC_000165.1.465 Q80YR2 F16B2_MOUSE 84.409 0.99729 0.991935 Fhip2b - FHF complex subunit HOOK interacting protein 2B - Mus musculus (Mouse) - Fhip2b gene Able to activate MAPK/ERK and TGFB signaling pathways (By similarity). May regulate the activity of genes involved in intestinal barrier function and immunoprotective inflammation (PubMed:31862898). May play a role in cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000165.1.466 Q6ZVK8 NUD18_HUMAN 84.830 0.993827 1.0031 NUDT18 - 8-oxo-dGDP phosphatase NUDT18 - Homo sapiens (Human) - NUDT18 gene Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. Taurus_UMD|evm.model.AC_000165.1.467 O43593 HAIR_HUMAN 79.348 0.998291 0.98402 HR - Lysine-specific demethylase hairless - Homo sapiens (Human) - HR gene Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. Taurus_UMD|evm.model.AC_000165.1.468 Q3ZCI8 REEP4_BOVIN 100.000 0.992248 1.00389 REEP4 - Receptor expression-enhancing protein 4 - Bos taurus (Bovine) - REEP4 gene Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity). Taurus_UMD|evm.model.AC_000165.1.469 Q1EGL0 LGI3_PANTR 90.693 0.996344 0.998175 LGI3 - Leucine-rich repeat LGI family member 3 precursor - Pan troglodytes (Chimpanzee) - LGI3 gene May participate in the regulation of neuronal exocytosis. Taurus_UMD|evm.model.AC_000165.1.470 P15783 PSPC_BOVIN 100.000 0.891509 1.11579 SFTPC - Pulmonary surfactant-associated protein C precursor - Bos taurus (Bovine) - SFTPC gene Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. Taurus_UMD|evm.model.AC_000165.1.472 P13497 BMP1_HUMAN 92.316 0.971846 0.972617 BMP1 - Bone morphogenetic protein 1 precursor - Homo sapiens (Human) - BMP1 gene Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins (PubMed:33206546). Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:33169406, PubMed:32636307). Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers (PubMed:31152061, PubMed:33206546). Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (PubMed:32636307). Taurus_UMD|evm.model.AC_000165.1.473 Q0VD34 PHYIP_BOVIN 100.000 0.993958 1.00303 PHYHIP - Phytanoyl-CoA hydroxylase-interacting protein - Bos taurus (Bovine) - PHYHIP gene Its interaction with PHYH suggests a role in the development of the central system. Taurus_UMD|evm.model.AC_000165.1.474 Q5E9Z7 RPC4_BOVIN 100.000 0.994987 1.00251 POLR3D - DNA-directed RNA polymerase III subunit RPC4 - Bos taurus (Bovine) - POLR3D gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Taurus_UMD|evm.model.AC_000165.1.475 Q8TC59 PIWL2_HUMAN 76.465 0.997714 0.899281 PIWIL2 - Piwi-like protein 2 - Homo sapiens (Human) - PIWIL2 gene Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660). Represses circadian rhythms by promoting the stability and activity of core clock components ARNTL/BMAL1 and CLOCK by inhibiting GSK3B-mediated phosphorylation and ubiquitination-dependent degradation of these proteins (PubMed:28903391). Taurus_UMD|evm.model.AC_000165.1.476 A5D7L5 S39AE_BOVIN 100.000 0.995927 1.00204 SLC39A14 - Metal cation symporter ZIP14 precursor - Bos taurus (Bovine) - SLC39A14 gene Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (By similarity). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions. Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity). Taurus_UMD|evm.model.AC_000165.1.477 P48454 PP2BC_HUMAN 93.725 0.967495 1.02148 PPP3CC - Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform - Homo sapiens (Human) - PPP3CC gene Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Taurus_UMD|evm.model.AC_000165.1.478 O60504 VINEX_HUMAN 83.235 0.931129 1.08197 SORBS3 - Vinexin - Homo sapiens (Human) - SORBS3 gene Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. Taurus_UMD|evm.model.AC_000165.1.480 Q3T0C8 PDLI2_BOVIN 100.000 0.994269 1.00287 PDLIM2 - PDZ and LIM domain protein 2 - Bos taurus (Bovine) - PDLIM2 gene Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity). Taurus_UMD|evm.model.AC_000165.1.481 Q8NAV2 CH058_HUMAN 58.268 0.992105 1.0411 C8orf58 - Uncharacterized protein C8orf58 - Homo sapiens (Human) - C8orf58 gene Taurus_UMD|evm.model.AC_000165.1.483 Q5R8S0 CCAR2_PONAB 90.196 0.997819 0.998911 CCAR2 - Cell cycle and apoptosis regulator protein 2 - Pongo abelii (Sumatran orangutan) - CCAR2 gene Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (By similarity). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (By similarity). Inhibits SUV39H1 methyltransferase activity (By similarity). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (By similarity). Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1 (By similarity). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (By similarity). Represses the ligand-dependent transcriptional activation function of ESR2 (By similarity). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (By similarity). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (By similarity). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (By similarity). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (By similarity). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (By similarity). Represses the transcriptional activator activity of BRCA1 (By similarity). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (By similarity). Taurus_UMD|evm.model.AC_000165.1.484 Q9NQY0 BIN3_HUMAN 95.600 0.972656 1.01186 BIN3 - Bridging integrator 3 - Homo sapiens (Human) - BIN3 gene Involved in cytokinesis and septation where it has a role in the localization of F-actin. Taurus_UMD|evm.model.AC_000165.1.485 Q06889 EGR3_HUMAN 98.966 0.994845 1.00258 EGR3 - Early growth response protein 3 - Homo sapiens (Human) - EGR3 gene Probable transcription factor involved in muscle spindle development. Taurus_UMD|evm.model.AC_000165.1.486 Q96S96 PEBP4_HUMAN 72.146 0.973214 0.986784 PEBP4 - Phosphatidylethanolamine-binding protein 4 precursor - Homo sapiens (Human) - PEBP4 gene Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway. Taurus_UMD|evm.model.AC_000165.1.487 Q91V93 RHBT2_MOUSE 91.255 0.965659 1 Rhobtb2 - Rho-related BTB domain-containing protein 2 - Mus musculus (Mouse) - Rhobtb2 gene cell cortex, cell projection, cytoplasmic vesicle, cytoskeleton, intracellular membrane-bounded organelle, plasma membrane, GTP binding, GTPase activity, protein kinase binding, actin filament organization Taurus_UMD|evm.model.AC_000165.1.488 Q91V93 RHBT2_MOUSE 83.546 0.961095 0.953297 Rhobtb2 - Rho-related BTB domain-containing protein 2 - Mus musculus (Mouse) - Rhobtb2 gene cell cortex, cell projection, cytoplasmic vesicle, cytoskeleton, intracellular membrane-bounded organelle, plasma membrane, GTP binding, GTPase activity, protein kinase binding, actin filament organization Taurus_UMD|evm.model.AC_000165.1.489 Q91V93 RHBT2_MOUSE 83.694 0.728792 1.06868 Rhobtb2 - Rho-related BTB domain-containing protein 2 - Mus musculus (Mouse) - Rhobtb2 gene cell cortex, cell projection, cytoplasmic vesicle, cytoskeleton, intracellular membrane-bounded organelle, plasma membrane, GTP binding, GTPase activity, protein kinase binding, actin filament organization Taurus_UMD|evm.model.AC_000165.1.490 O14798 TR10C_HUMAN 47.260 0.43465 1.27027 TNFRSF10C - Tumor necrosis factor receptor superfamily member 10C precursor - Homo sapiens (Human) - TNFRSF10C gene Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Taurus_UMD|evm.model.AC_000165.1.491 Q13136 LIPA1_HUMAN 44.466 0.95045 0.369384 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000165.1.492 Q13136 LIPA1_HUMAN 67.021 0.592417 0.351082 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000165.1.494 A6QQT9 HACL2_BOVIN 94.253 0.452632 0.300633 ILVBL - 2-hydroxyacyl-CoA lyase 2 - Bos taurus (Bovine) - ILVBL gene Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway. Taurus_UMD|evm.model.AC_000165.1.496 A6QQT9 HACL2_BOVIN 81.329 0.991319 0.911392 ILVBL - 2-hydroxyacyl-CoA lyase 2 - Bos taurus (Bovine) - ILVBL gene Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway. Taurus_UMD|evm.model.AC_000165.1.497 A6QQT9 HACL2_BOVIN 91.935 0.426573 0.226266 ILVBL - 2-hydroxyacyl-CoA lyase 2 - Bos taurus (Bovine) - ILVBL gene Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway. Taurus_UMD|evm.model.AC_000165.1.498 O00220 TR10A_HUMAN 49.198 0.587459 0.647436 TNFRSF10A - Tumor necrosis factor receptor superfamily member 10A precursor - Homo sapiens (Human) - TNFRSF10A gene Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF-kappa-B (PubMed:9430227). Taurus_UMD|evm.model.AC_000165.1.501 Q8WUX9 CHMP7_HUMAN 96.889 0.995565 0.995585 CHMP7 - Charged multivesicular body protein 7 - Homo sapiens (Human) - CHMP7 gene ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway (PubMed:16856878). Taurus_UMD|evm.model.AC_000165.1.502 Q9Y3T6 R3HC1_HUMAN 76.941 0.89002 1.11591 R3HCC1 - R3H and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - R3HCC1 gene Taurus_UMD|evm.model.AC_000165.1.503 A6H737 LOXL2_BOVIN 93.734 0.997403 0.994832 LOXL2 - Lysyl oxidase homolog 2 precursor - Bos taurus (Bovine) - LOXL2 gene Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin CDH1, probably by mediating deamination of histone H3. During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription. SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits. Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction. When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. Taurus_UMD|evm.model.AC_000165.1.504 A6H737 LOXL2_BOVIN 98.077 0.607143 0.108527 LOXL2 - Lysyl oxidase homolog 2 precursor - Bos taurus (Bovine) - LOXL2 gene Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin CDH1, probably by mediating deamination of histone H3. During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription. SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits. Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction. When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. Taurus_UMD|evm.model.AC_000165.1.505 Q9Y227 ENTP4_HUMAN 93.841 0.996732 0.993506 ENTPD4 - Ectonucleoside triphosphate diphosphohydrolase 4 - Homo sapiens (Human) - ENTPD4 gene Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP. AMP, ADP, ATP and UMP are not substrates (PubMed:10858452, PubMed:9556635). Preferentially activated by Ca(2+) over Mg(2+) (PubMed:10858452). Taurus_UMD|evm.model.AC_000165.1.506 Q3ZBJ8 MFRN1_BOVIN 99.329 0.436578 1.98246 SLC25A37 - Mitoferrin-1 - Bos taurus (Bovine) - SLC25A37 gene Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). Taurus_UMD|evm.model.AC_000165.1.508 P70061 NKX32_XENLA 77.612 0.275 0.729483 nkx3-2 - Homeobox protein Nkx-3.2 - Xenopus laevis (African clawed frog) - nkx3-2 gene nucleus, DNA binding, positive regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000165.1.509 A6NCS4 NKX26_HUMAN 72.333 0.827298 1.19269 NKX2-6 - Homeobox protein Nkx-2.6 - Homo sapiens (Human) - NKX2-6 gene Acts as a transcriptional activator (PubMed:15649947). In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development. Taurus_UMD|evm.model.AC_000165.1.511 Q9N0T1 STC1_BOVIN 100.000 0.991935 1.00405 STC1 - Stanniocalcin-1 precursor - Bos taurus (Bovine) - STC1 gene Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia. Taurus_UMD|evm.model.AC_000165.1.512 P31950 S10AB_PIG 84.375 0.984375 0.646465 S100A11 - Protein S100-A11 - Sus scrofa (Pig) - S100A11 gene Facilitates the differentiation and the cornification of keratinocytes. Taurus_UMD|evm.model.AC_000165.1.513 Q63486 RRAGA_RAT 98.400 0.984127 0.402556 Rraga - Ras-related GTP-binding protein A - Rattus norvegicus (Rat) - Rraga gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. Taurus_UMD|evm.model.AC_000165.1.514 Q63486 RRAGA_RAT 100.000 0.913669 0.444089 Rraga - Ras-related GTP-binding protein A - Rattus norvegicus (Rat) - Rraga gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. Taurus_UMD|evm.model.AC_000165.1.515 O15204 ADEC1_HUMAN 76.840 0.377049 2.59574 ADAMDEC1 - ADAM DEC1 precursor - Homo sapiens (Human) - ADAMDEC1 gene May play an important role in the control of the immune response and during pregnancy. Taurus_UMD|evm.model.AC_000165.1.516 Q28475 ADAM7_MACFA 69.075 0.997468 1.01804 ADAM7 - Disintegrin and metalloproteinase domain-containing protein 7 precursor - Macaca fascicularis (Crab-eating macaque) - ADAM7 gene May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity). Taurus_UMD|evm.model.AC_000165.1.517 P01871 IGHM_HUMAN 54.762 0.146953 1.23179 IGHM - Immunoglobulin heavy constant mu - Homo sapiens (Human) - IGHM gene Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553). Taurus_UMD|evm.model.AC_000165.1.518 P04221 MUCM_RABIT 64.301 0.90595 1.08768 Ig mu chain C region membrane-bound form - Oryctolagus cuniculus (Rabbit) Taurus_UMD|evm.model.AC_000165.1.519 O77788 NFM_BOVIN 99.033 0.997854 1.00648 NEFM - Neurofilament medium polypeptide - Bos taurus (Bovine) - NEFM gene Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). Taurus_UMD|evm.model.AC_000165.1.521 P02548 NFL_BOVIN 100.000 0.996403 1.0018 NEFL - Neurofilament light polypeptide - Bos taurus (Bovine) - NEFL gene Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). Taurus_UMD|evm.model.AC_000165.1.522 Q9H7D0 DOCK5_HUMAN 94.599 0.99893 1 DOCK5 - Dedicator of cytokinesis protein 5 - Homo sapiens (Human) - DOCK5 gene Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Taurus_UMD|evm.model.AC_000165.1.523 Q7L273 KCTD9_HUMAN 98.972 0.994872 1.00257 KCTD9 - BTB/POZ domain-containing protein KCTD9 - Homo sapiens (Human) - KCTD9 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. Taurus_UMD|evm.model.AC_000165.1.524 Q29RT4 CDCA2_BOVIN 92.098 0.766595 0.461919 CDCA2 - Cell division cycle-associated protein 2 - Bos taurus (Bovine) - CDCA2 gene Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates (By similarity). Taurus_UMD|evm.model.AC_000165.1.525 Q29RT4 CDCA2_BOVIN 99.445 0.987203 0.541048 CDCA2 - Cell division cycle-associated protein 2 - Bos taurus (Bovine) - CDCA2 gene Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates (By similarity). Taurus_UMD|evm.model.AC_000165.1.526 Q08DL5 COE2_BOVIN 98.305 0.748936 0.408696 EBF2 - Transcription factor COE2 - Bos taurus (Bovine) - EBF2 gene Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). Taurus_UMD|evm.model.AC_000165.1.528 Q08DL5 COE2_BOVIN 85.294 0.0884718 0.648696 EBF2 - Transcription factor COE2 - Bos taurus (Bovine) - EBF2 gene Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). Taurus_UMD|evm.model.AC_000165.1.529 Q08DL5 COE2_BOVIN 100.000 0.84127 0.328696 EBF2 - Transcription factor COE2 - Bos taurus (Bovine) - EBF2 gene Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). Taurus_UMD|evm.model.AC_000165.1.530 P63150 2ABA_RABIT 100.000 0.995506 0.995526 PPP2R2A - Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform - Oryctolagus cuniculus (Rabbit) - PPP2R2A gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Taurus_UMD|evm.model.AC_000165.1.531 Q3T013 BNI3L_BOVIN 100.000 0.990909 1.00457 BNIP3L - BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like - Bos taurus (Bovine) - BNIP3L gene Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May function as a tumor suppressor (By similarity). Taurus_UMD|evm.model.AC_000165.1.532 Q2KIT6 PNMA2_BOVIN 99.725 0.994521 1.00275 PNMA2 - Paraneoplastic antigen Ma2 homolog - Bos taurus (Bovine) - PNMA2 gene Taurus_UMD|evm.model.AC_000165.1.534 O02675 DPYL2_BOVIN 100.000 0.99651 1.00175 DPYSL2 - Dihydropyrimidinase-related protein 2 - Bos taurus (Bovine) - DPYSL2 gene Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity). Taurus_UMD|evm.model.AC_000165.1.535 P18130 ADA1A_BOVIN 100.000 0.99061 0.914163 ADRA1A - Alpha-1A adrenergic receptor - Bos taurus (Bovine) - ADRA1A gene This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). Taurus_UMD|evm.model.AC_000165.1.536 Q5R4C5 STMN4_PONAB 87.500 0.990783 1.14815 STMN4 - Stathmin-4 - Pongo abelii (Sumatran orangutan) - STMN4 gene Exhibits microtubule-destabilizing activity. Taurus_UMD|evm.model.AC_000165.1.537 Q9UPQ4 TRI35_HUMAN 88.618 0.993927 1.00203 TRIM35 - E3 ubiquitin-protein ligase TRIM35 - Homo sapiens (Human) - TRIM35 gene E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via DDX58/RIG-I signaling pathway (PubMed:32562145). Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145). Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537). Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). Taurus_UMD|evm.model.AC_000165.1.538 Q14289 FAK2_HUMAN 95.257 0.961165 1.02081 PTK2B - Protein-tyrosine kinase 2-beta - Homo sapiens (Human) - PTK2B gene Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. Taurus_UMD|evm.model.AC_000165.1.539 Q15822 ACHA2_HUMAN 81.698 0.996055 0.958412 CHRNA2 - Neuronal acetylcholine receptor subunit alpha-2 precursor - Homo sapiens (Human) - CHRNA2 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Taurus_UMD|evm.model.AC_000165.1.540 Q6Q2C2 HYES_PIG 79.279 0.996403 1.0018 EPHX2 - Bifunctional epoxide hydrolase 2 - Sus scrofa (Pig) - EPHX2 gene Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:15308618). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (By similarity). Taurus_UMD|evm.model.AC_000165.1.541 Q3ZC33 GGLO_BOVIN 100.000 0.995465 1.00227 GULO - L-gulonolactone oxidase - Bos taurus (Bovine) - GULO gene Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate. Taurus_UMD|evm.model.AC_000165.1.542 Q7YRZ2 APTX_BOVIN 100.000 0.430845 2.29494 APTX - Aprataxin - Bos taurus (Bovine) - APTX gene DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). Taurus_UMD|evm.model.AC_000165.1.543 Q5E954 DNJA1_BOVIN 100.000 0.994975 1.00252 DNAJA1 - DnaJ homolog subfamily A member 1 precursor - Bos taurus (Bovine) - DNAJA1 gene Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Taurus_UMD|evm.model.AC_000165.1.544 Q3UKJ7 SMU1_MOUSE 100.000 0.996109 1.00195 Smu1 - WD40 repeat-containing protein SMU1 - Mus musculus (Mouse) - Smu1 gene Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity). Taurus_UMD|evm.model.AC_000165.1.545 P02301 H3C_MOUSE 53.600 0.970874 0.757353 H3-5 - Histone H3.3C - Mus musculus (Mouse) - H3-5 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000165.1.546 P08037 B4GT1_BOVIN 100.000 0.995037 1.00249 B4GALT1 - Beta-1,4-galactosyltransferase 1 - Bos taurus (Bovine) - B4GALT1 gene The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Taurus_UMD|evm.model.AC_000165.1.547 P37109 ISK4_PIG 81.944 0.972603 0.848837 SPINK4 - Serine protease inhibitor Kazal-type 4 precursor - Sus scrofa (Pig) - SPINK4 gene Inhibits the glucose-induced insulin secretion from perfused pancreas; also plays a role in the immune system. Does not inhibit trypsin. Taurus_UMD|evm.model.AC_000165.1.548 Q99933 BAG1_HUMAN 83.898 0.987395 0.689855 BAG1 - BAG family molecular chaperone regulator 1 - Homo sapiens (Human) - BAG1 gene Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631). Taurus_UMD|evm.model.AC_000165.1.549 Q5RBR3 CHMP5_PONAB 99.087 0.990909 1.00457 CHMP5 - Charged multivesicular body protein 5 - Pongo abelii (Sumatran orangutan) - CHMP5 gene Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity). Taurus_UMD|evm.model.AC_000165.1.550 A6QLA0 NFX1_BOVIN 100.000 0.998209 1.0009 NFX1 - Transcriptional repressor NF-X1 - Bos taurus (Bovine) - NFX1 gene Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination (By similarity). Taurus_UMD|evm.model.AC_000165.1.551 P56403 AQP7_RAT 71.937 0.758308 1.23048 Aqp7 - Aquaporin-7 - Rattus norvegicus (Rat) - Aqp7 gene Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9252401). The channel is also permeable to urea (PubMed:9252401). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity). Taurus_UMD|evm.model.AC_000165.1.552 Q08DE6 AQP3_BOVIN 100.000 0.993174 1.00342 AQP3 - Aquaporin-3 - Bos taurus (Bovine) - AQP3 gene Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. Taurus_UMD|evm.model.AC_000165.1.553 Q9H6R4 NOL6_HUMAN 89.791 0.998256 1.00087 NOL6 - Nucleolar protein 6 - Homo sapiens (Human) - NOL6 gene condensed nuclear chromosome, CURI complex, mitochondrion, nucleolus, nucleoplasm, small-subunit processome, UTP-C complex, RNA binding, rRNA processing, tRNA export from nucleus Taurus_UMD|evm.model.AC_000165.1.554 Q29503 UB2R2_RABIT 100.000 0.991632 1.0042 UBE2R2 - Ubiquitin-conjugating enzyme E2 R2 - Oryctolagus cuniculus (Rabbit) - UBE2R2 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin. Taurus_UMD|evm.model.AC_000165.1.555 Q5T6F2 UBAP2_HUMAN 84.081 0.998208 0.997319 UBAP2 - Ubiquitin-associated protein 2 - Homo sapiens (Human) - UBAP2 gene cytoplasm, nucleus, P-body, cadherin binding, RNA binding, regulation of gene expression Taurus_UMD|evm.model.AC_000165.1.556 Q3MHH0 DCA12_BOVIN 100.000 0.995595 1.00221 DCAF12 - DDB1- and CUL4-associated factor 12 - Bos taurus (Bovine) - DCAF12 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Taurus_UMD|evm.model.AC_000165.1.557 Q9NZ09 UBAP1_HUMAN 92.032 0.996024 1.00199 UBAP1 - Ubiquitin-associated protein 1 - Homo sapiens (Human) - UBAP1 gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:24284069, PubMed:22405001, PubMed:31203368). Taurus_UMD|evm.model.AC_000165.1.558 Q5T7B8 KIF24_HUMAN 74.805 0.998577 1.02705 KIF24 - Kinesin-like protein KIF24 - Homo sapiens (Human) - KIF24 gene Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Taurus_UMD|evm.model.AC_000165.1.559 Q29RJ1 AP4A_BOVIN 100.000 0.986486 1.0068 NUDT2 - Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] - Bos taurus (Bovine) - NUDT2 gene Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. Taurus_UMD|evm.model.AC_000165.1.560 Q6NSJ0 MYORG_HUMAN 93.846 0.997203 1.0014 MYORG - Myogenesis-regulating glycosidase - Homo sapiens (Human) - MYORG gene Putative glycosidase. Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2. Taurus_UMD|evm.model.AC_000165.1.561 Q32KP0 SMRP1_BOVIN 100.000 0.993443 1.00329 SMRP1 - Spermatid-specific manchette-related protein 1 - Bos taurus (Bovine) - SMRP1 gene May play a role in spermatogenesis. May be involved in differentiation or function of ciliated cells (By similarity). Taurus_UMD|evm.model.AC_000165.1.563 Q8IW50 F219A_HUMAN 100.000 0.989247 1.00541 FAM219A - Protein FAM219A - Homo sapiens (Human) - FAM219A gene Taurus_UMD|evm.model.AC_000165.1.564 Q32KS2 DNAI1_BOVIN 100.000 0.997155 1.00142 DNAI1 - Dynein axonemal intermediate chain 1 - Bos taurus (Bovine) - DNAI1 gene Part of the dynein complex of respiratory cilia. Taurus_UMD|evm.model.AC_000165.1.565 A2VE22 ENHO_BOVIN 97.260 0.514286 1.84211 ENHO - Adropin precursor - Bos taurus (Bovine) - ENHO gene Involved in the regulation of glucose homeostasis and lipid metabolism. Taurus_UMD|evm.model.AC_000165.1.566 P26992 CNTFR_HUMAN 96.067 0.747368 1.27688 CNTFR - Ciliary neurotrophic factor receptor subunit alpha precursor - Homo sapiens (Human) - CNTFR gene Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 (PubMed:26858303). Taurus_UMD|evm.model.AC_000165.1.567 Q2KIR4 RP25L_BOVIN 100.000 0.987805 1.00613 RPP25L - Ribonuclease P protein subunit p25-like protein - Bos taurus (Bovine) - RPP25L gene May be a component of ribonuclease P or MRP. Taurus_UMD|evm.model.AC_000165.1.568 Q0P5A1 DCTN3_BOVIN 100.000 0.989305 1.00538 DCTN3 - Dynactin subunit 3 - Bos taurus (Bovine) - DCTN3 gene Together with dynein may be involved in spindle assembly and cytokinesis. Taurus_UMD|evm.model.AC_000165.1.569 A6NKF2 ARI3C_HUMAN 82.759 0.959135 1.00971 ARID3C - AT-rich interactive domain-containing protein 3C - Homo sapiens (Human) - ARID3C gene membrane raft, nucleus, DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000165.1.570 Q58DH7 SGMR1_BOVIN 100.000 0.991071 1.00448 SIGMAR1 - Sigma non-opioid intracellular receptor 1 - Bos taurus (Bovine) - SIGMAR1 gene Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (By similarity). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity). Taurus_UMD|evm.model.AC_000165.1.571 P07902 GALT_HUMAN 92.997 0.98615 0.952507 GALT - Galactose-1-phosphate uridylyltransferase - Homo sapiens (Human) - GALT gene Plays an important role in galactose metabolism. Taurus_UMD|evm.model.AC_000165.1.572 Q5RF19 I11RA_PONAB 85.782 0.880753 1.1327 IL11RA - Interleukin-11 receptor subunit alpha precursor - Pongo abelii (Sumatran orangutan) - IL11RA gene Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Taurus_UMD|evm.model.AC_000165.1.573 Q9Z1X0 CCL27_MOUSE 68.421 0.783333 1 Ccl27 - C-C motif chemokine 27 precursor - Mus musculus (Mouse) - Ccl27 gene Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. May play a role in cell migration during embryogenesis. Nuclear forms may facilitate cellular migration by inducing cytoskeletal relaxation. Binds to CCR10. Taurus_UMD|evm.model.AC_000165.1.575 O70460 CCL19_MOUSE 73.958 0.902913 0.953704 Ccl19 - C-C motif chemokine 19 precursor - Mus musculus (Mouse) - Ccl19 gene Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. Taurus_UMD|evm.model.AC_000165.1.576 O00585 CCL21_HUMAN 72.519 0.970149 1 CCL21 - C-C motif chemokine 21 precursor - Homo sapiens (Human) - CCL21 gene Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. Taurus_UMD|evm.model.AC_000165.1.577 Q63HN1 F205B_HUMAN 60.791 0.429348 2.31655 FAM205BP - Putative protein FAM205B - Homo sapiens (Human) - FAM205BP gene Taurus_UMD|evm.model.AC_000165.1.579 Q8IZ41 RASEF_HUMAN 89.459 0.997301 1.00135 RASEF - Ras and EF-hand domain-containing protein - Homo sapiens (Human) - RASEF gene Binds predominantly GDP, and also GTP (PubMed:17448446). Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules (PubMed:30814157). Taurus_UMD|evm.model.AC_000165.1.580 A2A2Y4 FRMD3_HUMAN 95.477 0.99665 1 FRMD3 - FERM domain-containing protein 3 - Homo sapiens (Human) - FRMD3 gene Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. Taurus_UMD|evm.model.AC_000165.1.581 Q5T6J7 GNTK_HUMAN 80.541 0.989247 0.994652 IDNK - Probable gluconokinase - Homo sapiens (Human) - IDNK gene gluconokinase activity, D-gluconate catabolic process Taurus_UMD|evm.model.AC_000165.1.582 Q9UMX0 UBQL1_HUMAN 94.737 0.99661 1.0017 UBQLN1 - Ubiquilin-1 - Homo sapiens (Human) - UBQLN1 gene Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Isoform 1, isoform 2 and isoform 3 play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Isoform 1 and isoform 3 play a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently downregulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity). Taurus_UMD|evm.model.AC_000165.1.583 Q9JLS3 TAOK2_RAT 90.686 0.789883 0.208097 Taok2 - Serine/threonine-protein kinase TAO2 - Rattus norvegicus (Rat) - Taok2 gene Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14/p38 MAPK activation. Taurus_UMD|evm.model.AC_000165.1.584 Q32LE2 GKAP1_BOVIN 100.000 0.994505 1.00275 GKAP1 - G kinase-anchoring protein 1 - Bos taurus (Bovine) - GKAP1 gene Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation. Taurus_UMD|evm.model.AC_000165.1.585 Q86VH2 KIF27_HUMAN 87.009 0.998567 0.996431 KIF27 - Kinesin-like protein KIF27 - Homo sapiens (Human) - KIF27 gene Plays an essential role in motile ciliogenesis. Taurus_UMD|evm.model.AC_000165.1.586 Q1JP73 QSPP_BOVIN 99.707 0.994152 1.00293 Queuosine salvage protein - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000165.1.587 Q3T0D0 HNRPK_BOVIN 100.000 0.899029 1.10991 HNRNPK - Heterogeneous nuclear ribonucleoprotein K - Bos taurus (Bovine) - HNRNPK gene One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest (By similarity). Taurus_UMD|evm.model.AC_000165.1.588 A4IF98 RMI1_BOVIN 100.000 0.928934 0.947115 RMI1 - RecQ-mediated genome instability protein 1 - Bos taurus (Bovine) - RMI1 gene Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity). Taurus_UMD|evm.model.AC_000165.1.590 Q9HAS3 S28A3_HUMAN 77.042 0.926702 1.10564 SLC28A3 - Solute carrier family 28 member 3 - Homo sapiens (Human) - SLC28A3 gene Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine. Taurus_UMD|evm.model.AC_000165.1.591 A1XQR9 RUXE_PIG 89.855 0.971429 0.76087 SNRPE - Small nuclear ribonucleoprotein E - Sus scrofa (Pig) - SNRPE gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. Taurus_UMD|evm.model.AC_000165.1.592 Q16620 NTRK2_HUMAN 92.918 0.972746 0.580292 NTRK2 - BDNF/NT-3 growth factors receptor precursor - Homo sapiens (Human) - NTRK2 gene Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. Taurus_UMD|evm.model.AC_000165.1.593 Q16620 NTRK2_HUMAN 100.000 0.821759 0.525547 NTRK2 - BDNF/NT-3 growth factors receptor precursor - Homo sapiens (Human) - NTRK2 gene Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. Taurus_UMD|evm.model.AC_000165.1.595 Q9UPW5 CBPC1_HUMAN 94.861 0.997553 1 AGTPBP1 - Cytosolic carboxypeptidase 1 - Homo sapiens (Human) - AGTPBP1 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins (PubMed:30420557). Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Taurus_UMD|evm.model.AC_000165.1.596 Q5RBT3 NAA35_PONAB 99.172 0.898263 1.11172 NAA35 - N-alpha-acetyltransferase 35, NatC auxiliary subunit - Pongo abelii (Sumatran orangutan) - NAA35 gene Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells (By similarity). Taurus_UMD|evm.model.AC_000165.1.597 Q8NBJ4 GOLM1_HUMAN 81.481 0.995074 1.01247 GOLM1 - Golgi membrane protein 1 - Homo sapiens (Human) - GOLM1 gene Unknown. Cellular response protein to viral infection. Taurus_UMD|evm.model.AC_000165.1.599 Q5TBE3 CI153_HUMAN 49.333 0.279693 2.58416 C9orf153 - Uncharacterized protein C9orf153 - Homo sapiens (Human) - C9orf153 gene Taurus_UMD|evm.model.AC_000165.1.600 Q4R5F0 ISCA1_MACFA 100.000 0.984615 1.00775 ISCA1 - Iron-sulfur cluster assembly 1 homolog, mitochondrial precursor - Macaca fascicularis (Crab-eating macaque) - ISCA1 gene Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. Taurus_UMD|evm.model.AC_000165.1.601 Q5VYS8 TUT7_HUMAN 86.043 0.951488 1.03411 TUT7 - Terminal uridylyltransferase 7 - Homo sapiens (Human) - TUT7 gene Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:25979828, PubMed:25480299, PubMed:19703396, PubMed:22898984, PubMed:18172165, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). Taurus_UMD|evm.model.AC_000165.1.603 P54826 GAS1_HUMAN 92.353 0.974138 1.0087 GAS1 - Growth arrest-specific protein 1 precursor - Homo sapiens (Human) - GAS1 gene Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. Taurus_UMD|evm.model.AC_000165.1.604 A8D8X1 RL10_SHEEP 79.730 0.972603 0.341121 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000165.1.606 P53355 DAPK1_HUMAN 95.804 0.998602 1.0007 DAPK1 - Death-associated protein kinase 1 - Homo sapiens (Human) - DAPK1 gene Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition. Taurus_UMD|evm.model.AC_000165.1.607 Q9GL24 CATL1_CANLF 78.144 0.994012 1.003 CTSL - Procathepsin L precursor - Canis lupus familiaris (Dog) - CTSL gene Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells. Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (By similarity). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity). Taurus_UMD|evm.model.AC_000165.1.608 Q2KJJ9 F16P2_BOVIN 90.855 0.993528 0.911504 FBP2 - Fructose-1,6-bisphosphatase isozyme 2 - Bos taurus (Bovine) - FBP2 gene Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. Taurus_UMD|evm.model.AC_000165.1.609 Q3SZB7 F16P1_BOVIN 100.000 0.9941 1.00296 FBP1 - Fructose-1,6-bisphosphatase 1 - Bos taurus (Bovine) - FBP1 gene Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. Taurus_UMD|evm.model.AC_000165.1.611 O19104 FANCC_BOVIN 98.944 0.996485 1.00353 FANCC - Fanconi anemia group C protein homolog - Bos taurus (Bovine) - FANCC gene DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity). Taurus_UMD|evm.model.AC_000165.1.612 Q13635 PTC1_HUMAN 95.048 0.998624 1.00484 PTCH1 - Protein patched homolog 1 - Homo sapiens (Human) - PTCH1 gene Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. Taurus_UMD|evm.model.AC_000165.1.614 A3KMX0 ER6L2_BOVIN 100.000 0.998717 1.00064 ERCC6L2 - DNA excision repair protein ERCC-6-like 2 - Bos taurus (Bovine) - ERCC6L2 gene May be involved in early DNA damage response. Taurus_UMD|evm.model.AC_000165.1.615 P37058 DHB3_HUMAN 80.968 0.993569 1.00323 HSD17B3 - Testosterone 17-beta-dehydrogenase 3 - Homo sapiens (Human) - HSD17B3 gene Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH (PubMed:26545797, PubMed:8075637, PubMed:16216911). Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (PubMed:16216911). Taurus_UMD|evm.model.AC_000165.1.616 Q76EJ3 S35D2_HUMAN 91.691 0.99115 1.00593 SLC35D2 - UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter - Homo sapiens (Human) - SLC35D2 gene Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. Taurus_UMD|evm.model.AC_000165.1.617 Q7RTV3 ZN367_HUMAN 92.308 0.994286 1 ZNF367 - Zinc finger protein 367 - Homo sapiens (Human) - ZNF367 gene Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes. Taurus_UMD|evm.model.AC_000165.1.618 Q5JVS0 HABP4_HUMAN 89.928 0.995215 1.01211 HABP4 - Intracellular hyaluronan-binding protein 4 - Homo sapiens (Human) - HABP4 gene RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation (PubMed:19523114). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Involved in mRNA translation regulation, probably at the initiation step (PubMed:21771594). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). Taurus_UMD|evm.model.AC_000165.1.619 A4D256 CC14C_HUMAN 87.345 0.822314 1.08277 CDC14C - Dual specificity protein phosphatase CDC14C - Homo sapiens (Human) - CDC14C gene Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity). Taurus_UMD|evm.model.AC_000165.1.620 Q6PFY9 CC14B_MOUSE 57.895 0.967391 0.189691 Cdc14b - Dual specificity protein phosphatase CDC14B - Mus musculus (Mouse) - Cdc14b gene Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity). Taurus_UMD|evm.model.AC_000165.1.621 Q148E0 PXL2C_BOVIN 100.000 0.991266 1.00439 PRXL2C - Peroxiredoxin-like 2C - Bos taurus (Bovine) - PRXL2C gene May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis. Taurus_UMD|evm.model.AC_000165.1.622 P62246 RS15A_RAT 100.000 0.984733 1.00769 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Taurus_UMD|evm.model.AC_000165.1.623 Q6ZMW2 ZN782_HUMAN 77.983 0.995733 1.00572 ZNF782 - Zinc finger protein 782 - Homo sapiens (Human) - ZNF782 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000165.1.624 P25975 CATL1_BOVIN 98.983 0.872404 1.00898 CTSL - Procathepsin L precursor - Bos taurus (Bovine) - CTSL gene Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (PubMed:12869695). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells. Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (By similarity). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity). Taurus_UMD|evm.model.AC_000165.1.625 A0A1B0GVZ2 F240B_HUMAN 85.714 0.962025 1.01282 FAM240B - Protein FAM240B - Homo sapiens (Human) - FAM240B gene Taurus_UMD|evm.model.AC_000165.1.627 Q5JVG2 ZN484_HUMAN 75.815 0.931684 0.996479 ZNF484 - Zinc finger protein 484 - Homo sapiens (Human) - ZNF484 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000165.1.628 P41252 SYIC_HUMAN 91.125 0.998416 1.00079 IARS1 - Isoleucine--tRNA ligase, cytoplasmic - Homo sapiens (Human) - IARS1 gene Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Taurus_UMD|evm.model.AC_000165.1.629 Q76FK4 NOL8_HUMAN 71.635 0.998252 0.980291 NOL8 - Nucleolar protein 8 - Homo sapiens (Human) - NOL8 gene Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. Taurus_UMD|evm.model.AC_000165.1.630 P19879 MIME_BOVIN 99.666 0.993333 1.00334 OGN - Mimecan precursor - Bos taurus (Bovine) - OGN gene Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2. Taurus_UMD|evm.model.AC_000165.1.631 O77742 OMD_BOVIN 99.763 0.995272 1.00237 OMD - Osteomodulin precursor - Bos taurus (Bovine) - OMD gene May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin. Taurus_UMD|evm.model.AC_000165.1.632 Q3ZBN5 ASPN_BOVIN 100.000 0.994609 1.0027 ASPN - Asporin precursor - Bos taurus (Bovine) - ASPN gene extracellular space Taurus_UMD|evm.model.AC_000165.1.633 Q3MHH9 ECM2_BOVIN 93.741 0.897772 1.12206 ECM2 - Extracellular matrix protein 2 precursor - Bos taurus (Bovine) - ECM2 gene Promotes matrix assembly and cell adhesiveness. Taurus_UMD|evm.model.AC_000165.1.634 Q6IPU0 CENPP_HUMAN 75.455 0.939655 0.402778 CENPP - Centromere protein P - Homo sapiens (Human) - CENPP gene Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Taurus_UMD|evm.model.AC_000165.1.635 Q9H8X2 IPPK_HUMAN 84.200 0.995859 0.983707 IPPK - Inositol-pentakisphosphate 2-kinase - Homo sapiens (Human) - IPPK gene Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. Taurus_UMD|evm.model.AC_000165.1.636 Q8TD16 BICD2_HUMAN 90.655 0.997519 0.978155 BICD2 - Protein bicaudal D homolog 2 - Homo sapiens (Human) - BICD2 gene Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). Taurus_UMD|evm.model.AC_000165.1.637 Q5R5T1 FGD3_PONAB 73.113 0.997301 1.00543 FGD3 - FYVE, RhoGEF and PH domain-containing protein 3 - Pongo abelii (Sumatran orangutan) - FGD3 gene Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). Taurus_UMD|evm.model.AC_000165.1.638 Q96L08 SUSD3_HUMAN 64.885 0.992218 1.00784 SUSD3 - Sushi domain-containing protein 3 - Homo sapiens (Human) - SUSD3 gene May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration. Taurus_UMD|evm.model.AC_000165.1.639 Q58D91 CAR19_BOVIN 99.454 0.98913 1.00546 CARD19 - Caspase recruitment domain-containing protein 19 - Bos taurus (Bovine) - CARD19 gene Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner. Taurus_UMD|evm.model.AC_000165.1.640 P70617 NINJ1_RAT 88.158 0.986842 1 Ninj1 - Ninjurin-1 - Rattus norvegicus (Rat) - Ninj1 gene Homophilic transmembrane adhesion molecule involved in various processes such as inflammation, cell death, axonal growth, cell chemotaxis and angiogenesis (By similarity). Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM) (PubMed:19595672). Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells (By similarity). Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding (By similarity). Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions (By similarity). Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS (By similarity). Acts as a mediator of both programmed and necrotic cell death (By similarity). Plays a key role in the induction of plasma membrane rupture during programmed and necrotic cell death: oligomerizes in response to death stimuli to mediate plasma membrane rupture (cytolysis), leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (By similarity). Plays a role in nerve regeneration by promoting maturation of Schwann cells (By similarity). Acts as a regulator of angiogenesis (PubMed:33028854). Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells (By similarity). Promotes osteoclasts development by enhancing the survival of prefusion osteoclasts (By similarity). Also involved in striated muscle growth and differentiation (By similarity). Taurus_UMD|evm.model.AC_000165.1.641 Q9Y3S1 WNK2_HUMAN 85.010 0.413034 0.988681 WNK2 - Serine/threonine-protein kinase WNK2 - Homo sapiens (Human) - WNK2 gene Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity. Taurus_UMD|evm.model.AC_000165.1.642 A6H7H1 F120A_BOVIN 99.904 0.998081 0.935368 FAM120A - Constitutive coactivator of PPAR-gamma-like protein 1 - Bos taurus (Bovine) - FAM120A gene Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May participate in mRNA transport in the cytoplasm (By similarity). Taurus_UMD|evm.model.AC_000165.1.643 O75151 PHF2_HUMAN 87.931 0.986239 0.994526 PHF2 - Lysine-specific demethylase PHF2 - Homo sapiens (Human) - PHF2 gene Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Taurus_UMD|evm.model.AC_000165.1.644 A5D7C3 MPZL3_BOVIN 92.233 0.953488 0.918803 MPZL3 - Myelin protein zero-like protein 3 precursor - Bos taurus (Bovine) - MPZL3 gene Mediates homophilic cell-cell adhesion. Taurus_UMD|evm.model.AC_000165.1.645 Q10994 CYTB_SHEEP 75.510 0.914286 1.07143 CSTB - Cystatin-B - Ovis aries (Sheep) - CSTB gene This is an intracellular thiol proteinase inhibitor. Taurus_UMD|evm.model.AC_000165.1.646 Q9W6D8 BARX1_CHICK 90.000 0.653285 1.32367 BARX1 - Homeobox protein BarH-like 1 - Gallus gallus (Chicken) - BARX1 gene Transcription factor, which is involved in craniofacial development, in odontogenic region definition, and in stomach organogenesis. Binds to a regulatory module of the NCAM promoter. Taurus_UMD|evm.model.AC_000165.1.647 A7E379 PTPC1_BOVIN 99.587 0.962815 0.94598 PTPDC1 - Protein tyrosine phosphatase domain-containing protein 1 - Bos taurus (Bovine) - PTPDC1 gene May play roles in cilia formation and/or maintenance. Taurus_UMD|evm.model.AC_000165.1.648 Q9BYV6 TRI55_HUMAN 34.254 0.452128 0.686131 TRIM55 - Tripartite motif-containing protein 55 - Homo sapiens (Human) - TRIM55 gene May regulate gene expression and protein turnover in muscle cells. Taurus_UMD|evm.model.AC_000165.1.649 Q14929 ZN169_HUMAN 72.910 0.913681 1.01824 ZNF169 - Zinc finger protein 169 - Homo sapiens (Human) - ZNF169 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000165.1.650 P0DKV0 S31C1_HUMAN 44.308 0.188295 1.32323 SPATA31C1 - Putative spermatogenesis-associated protein 31C1 - Homo sapiens (Human) - SPATA31C1 gene May play a role in spermatogenesis. Taurus_UMD|evm.model.AC_000165.1.651 Q6ZUB1 S31E1_HUMAN 42.982 0.391003 0.2 SPATA31E1 - Spermatogenesis-associated protein 31E1 - Homo sapiens (Human) - SPATA31E1 gene May play a role in spermatogenesis. Taurus_UMD|evm.model.AC_000165.1.654 Q5VT25 MRCKA_HUMAN 62.784 0.952756 0.439954 CDC42BPA - Serine/threonine-protein kinase MRCK alpha - Homo sapiens (Human) - CDC42BPA gene Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). Taurus_UMD|evm.model.AC_000165.1.655 Q3MHG1 SPTC1_BOVIN 100.000 0.995781 1.00211 SPTLC1 - Serine palmitoyltransferase 1 - Bos taurus (Bovine) - SPTLC1 gene Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). Required for adipocyte cell viability and metabolic homeostasis (By similarity). Taurus_UMD|evm.model.AC_000165.1.656 Q01974 ROR2_HUMAN 93.425 0.997875 0.997879 ROR2 - Tyrosine-protein kinase transmembrane receptor ROR2 precursor - Homo sapiens (Human) - ROR2 gene Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). Taurus_UMD|evm.model.AC_000165.1.658 Q08D88 NFIL3_BOVIN 100.000 0.99568 1.00216 NFIL3 - Nuclear factor interleukin-3-regulated protein - Bos taurus (Bovine) - NFIL3 gene Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity). Taurus_UMD|evm.model.AC_000165.1.659 Q13825 AUHM_HUMAN 80.328 0.887097 0.914454 AUH - Methylglutaconyl-CoA hydratase, mitochondrial precursor - Homo sapiens (Human) - AUH gene Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA (PubMed:11738050, PubMed:12434311, PubMed:12655555). Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Has very low enoyl-CoA hydratase activity (PubMed:7892223). Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs (PubMed:7892223). Taurus_UMD|evm.model.AC_000165.1.662 Q00655 KSYK_PIG 95.064 0.99682 1.00159 SYK - Tyrosine-protein kinase SYK - Sus scrofa (Pig) - SYK gene Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Required for the stimulation of neutrophil phagocytosis by IL15 (By similarity). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). Taurus_UMD|evm.model.AC_000165.1.663 Q5PR73 DIRA2_MOUSE 97.990 0.99 1.00503 Diras2 - GTP-binding protein Di-Ras2 precursor - Mus musculus (Mouse) - Diras2 gene Displays low GTPase activity and exists predominantly in the GTP-bound form. Taurus_UMD|evm.model.AC_000165.1.664 Q9Y6M4 KC1G3_HUMAN 68.116 0.951807 0.371365 CSNK1G3 - Casein kinase I isoform gamma-3 - Homo sapiens (Human) - CSNK1G3 gene Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Taurus_UMD|evm.model.AC_000165.1.666 Q2KIX1 GA45G_BOVIN 100.000 0.9875 1.00629 GADD45G - Growth arrest and DNA damage-inducible protein GADD45 gamma - Bos taurus (Bovine) - GADD45G gene Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity). Taurus_UMD|evm.model.AC_000165.1.667 Q29361 RL35_PIG 50.000 0.966667 0.487805 RPL35 - 60S ribosomal protein L35 - Sus scrofa (Pig) - RPL35 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000165.1.668 Q92854 SEM4D_HUMAN 84.473 0.997685 1.00232 SEMA4D - Semaphorin-4D precursor - Homo sapiens (Human) - SEMA4D gene Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). Taurus_UMD|evm.model.AC_000165.1.670 P56390 CKS2_MOUSE 100.000 0.0200846 11.9747 Cks2 - Cyclin-dependent kinases regulatory subunit 2 - Mus musculus (Mouse) - Cks2 gene Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. Taurus_UMD|evm.model.AC_000165.1.671 Q92529 SHC3_HUMAN 91.383 0.967033 0.765993 SHC3 - SHC-transforming protein 3 - Homo sapiens (Human) - SHC3 gene Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. Taurus_UMD|evm.model.AC_000165.1.672 Q99500 S1PR3_HUMAN 88.000 0.986807 1.00265 S1PR3 - Sphingosine 1-phosphate receptor 3 - Homo sapiens (Human) - S1PR3 gene Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Taurus_UMD|evm.model.AC_000165.1.674 Q5VZ03 NXNL2_HUMAN 85.806 0.980892 1.00641 NXNL2 - Nucleoredoxin-like protein 2 - Homo sapiens (Human) - NXNL2 gene May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons. Taurus_UMD|evm.model.AC_000165.1.675 Q5R997 SPIN1_PONAB 99.237 0.992395 1.00382 SPIN1 - Spindlin-1 - Pongo abelii (Sumatran orangutan) - SPIN1 gene Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. Taurus_UMD|evm.model.AC_000165.1.676 Q29463 TRY2_BOVIN 96.377 0.578059 0.959514 Anionic trypsin precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000165.1.678 Q9JHU3 CDK20_MOUSE 96.532 0.994236 1.00289 Cdk20 - Cyclin-dependent kinase 20 - Mus musculus (Mouse) - Cdk20 gene Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Taurus_UMD|evm.model.AC_000165.1.679 Q6X9E4 FBW12_HUMAN 36.693 0.91253 0.911638 FBXW12 - F-box/WD repeat-containing protein 12 - Homo sapiens (Human) - FBXW12 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000165.1.681 Q86Y26 NUTM1_HUMAN 59.740 0.670753 0.504417 NUTM1 - NUT family member 1 - Homo sapiens (Human) - NUTM1 gene Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. Taurus_UMD|evm.model.AC_000165.1.682 Q8IYR6 TEFF1_HUMAN 98.684 0.994723 0.997368 TMEFF1 - Tomoregulin-1 precursor - Homo sapiens (Human) - TMEFF1 gene May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers. Taurus_UMD|evm.model.AC_000165.1.683 A5PJI6 CAVN4_BOVIN 100.000 0.994475 1.00277 CAVIN4 - Caveolae-associated protein 4 - Bos taurus (Bovine) - CAVIN4 gene Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes. Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway. Taurus_UMD|evm.model.AC_000165.1.684 Q8TBJ4 PLPR1_HUMAN 96.990 0.949045 0.966154 PLPPR1 - Phospholipid phosphatase-related protein type 1 - Homo sapiens (Human) - PLPPR1 gene integral component of plasma membrane, nucleoplasm, lipid phosphatase activity, phosphatidate phosphatase activity, phospholipid dephosphorylation, phospholipid metabolic process, signal transduction Taurus_UMD|evm.model.AC_000165.1.685 Q5FVR5 ACNT2_RAT 65.871 0.995238 1.00478 Acnat2 - Acyl-coenzyme A amino acid N-acyltransferase 2 - Rattus norvegicus (Rat) - Acnat2 gene Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine (By similarity). Taurus_UMD|evm.model.AC_000165.1.686 Q91X34 BAAT_MOUSE 68.657 0.985075 0.159524 Baat - Bile acid-CoA:amino acid N-acyltransferase - Mus musculus (Mouse) - Baat gene Catalyzes the amidation of bile acids (BAs) with the amino acid taurine (PubMed:9215542). Selective for taurine conjugation of cholyl CoA and only taurine-conjugated BAs are found in bile (PubMed:9215542). Amidation of BAs in the liver with taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (By similarity). This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption (By similarity). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids (By similarity). In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (By similarity). Taurus_UMD|evm.model.AC_000165.1.687 Q2KI49 RM50_BOVIN 100.000 0.9875 1.00629 MRPL50 - 39S ribosomal protein L50, mitochondrial - Bos taurus (Bovine) - MRPL50 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Taurus_UMD|evm.model.AC_000165.1.688 O75820 ZN189_HUMAN 95.687 0.996737 0.979233 ZNF189 - Zinc finger protein 189 - Homo sapiens (Human) - ZNF189 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000165.1.689 Q3T0S5 ALDOB_BOVIN 99.451 0.862233 1.15659 ALDOB - Fructose-bisphosphate aldolase B - Bos taurus (Bovine) - ALDOB gene cytosol, fructose-1-phosphate aldolase activity, fructose-bisphosphate aldolase activity, fructose 1,6-bisphosphate metabolic process, glycolytic process Taurus_UMD|evm.model.AC_000165.1.690 A2VDP1 BRE1A_BOVIN 100.000 0.997951 1.00103 RNF20 - E3 ubiquitin-protein ligase BRE1A - Bos taurus (Bovine) - RNF20 gene Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of PA2G4 leading to its proteasome-mediated degradation. Taurus_UMD|evm.model.AC_000165.1.691 Q2TBI5 CANB2_BOVIN 100.000 0.435567 2.28235 PPP3R2 - Calcineurin subunit B type 2 - Bos taurus (Bovine) - PPP3R2 gene Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Taurus_UMD|evm.model.AC_000165.1.692 Q8TCU5 NMD3A_HUMAN 94.486 0.992481 0.834978 GRIN3A - Glutamate receptor ionotropic, NMDA 3A precursor - Homo sapiens (Human) - GRIN3A gene NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits, plays a role in the synaptic refinement period, restricting spine maturation and growth. By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses. May also play a role in PPP2CB-NMDAR mediated signaling mechanism. Taurus_UMD|evm.model.AC_000165.1.693 Q5R893 H2B1_PONAB 93.043 0.95 0.952381 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000165.1.694 Q28092 CYLC2_BOVIN 80.738 0.995062 0.829918 CYLC2 - Cylicin-2 - Bos taurus (Bovine) - CYLC2 gene Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. Taurus_UMD|evm.model.AC_000165.1.695 Q32L59 TMC5B_BOVIN 90.909 0.182203 0.672365 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Taurus_UMD|evm.model.AC_000165.1.696 P14381 YTX2_XENLA 26.974 0.722826 0.140673 Transposon TX1 uncharacterized 149 kDa protein - Xenopus laevis (African clawed frog) Taurus_UMD|evm.model.AC_000165.1.697 P68105 EF1A1_RABIT 100.000 0.982143 0.242424 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000165.1.698 A2Q0Z0 EF1A1_HORSE 100.000 0.851852 0.233766 EEF1A1 - Elongation factor 1-alpha 1 - Equus caballus (Horse) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000165.1.699 O95347 SMC2_HUMAN 93.031 0.969845 1.02506 SMC2 - Structural maintenance of chromosomes protein 2 - Homo sapiens (Human) - SMC2 gene Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Taurus_UMD|evm.model.AC_000165.1.700 Q80Z37 TOPRS_MOUSE 39.286 0.261808 0.717328 Topors - E3 ubiquitin-protein ligase Topors - Mus musculus (Mouse) - Topors gene Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA-damage-induced cell death through IKBKE sumoylation. Taurus_UMD|evm.model.AC_000165.1.701 Q93079 H2B1H_HUMAN 89.231 0.761905 0.666667 H2BC9 - Histone H2B type 1-H - Homo sapiens (Human) - H2BC9 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000165.1.702 Q5RAA9 NPS3A_PONAB 91.093 0.991935 1.00405 NIPSNAP3A - Protein NipSnap homolog 3A - Pongo abelii (Sumatran orangutan) - NIPSNAP3A gene Taurus_UMD|evm.model.AC_000165.1.703 O95477 ABCA1_HUMAN 75.510 0.311688 0.0681115 ABCA1 - Phospholipid-transporting ATPase ABCA1 - Homo sapiens (Human) - ABCA1 gene Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Thereby, participates in phospholipid transfer to apoliproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May play a similar role in the efflux of intracellular cholesterol to apoliproteins and the formation of nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981). Taurus_UMD|evm.model.AC_000165.1.704 O95477 ABCA1_HUMAN 94.646 0.959643 1.04113 ABCA1 - Phospholipid-transporting ATPase ABCA1 - Homo sapiens (Human) - ABCA1 gene Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Thereby, participates in phospholipid transfer to apoliproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May play a similar role in the efflux of intracellular cholesterol to apoliproteins and the formation of nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981). Taurus_UMD|evm.model.AC_000165.1.705 P46777 RL5_HUMAN 78.882 0.952381 0.565657 RPL5 - 60S ribosomal protein L5 - Homo sapiens (Human) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868, PubMed:23636399). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Taurus_UMD|evm.model.AC_000165.1.706 Q58DW5 RL5_BOVIN 70.000 0.94 0.673401 RPL5 - 60S ribosomal protein L5 - Bos taurus (Bovine) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Taurus_UMD|evm.model.AC_000165.1.707 Q8WWI5 CTL1_HUMAN 74.576 0.961749 0.278539 SLC44A1 - Choline transporter-like protein 1 - Homo sapiens (Human) - SLC44A1 gene Choline transporter. Involved in membrane synthesis and myelin production. Taurus_UMD|evm.model.AC_000165.1.708 Q8WWI5 CTL1_HUMAN 85.199 0.878594 0.476408 SLC44A1 - Choline transporter-like protein 1 - Homo sapiens (Human) - SLC44A1 gene Choline transporter. Involved in membrane synthesis and myelin production. Taurus_UMD|evm.model.AC_000165.1.709 Q8WWI5 CTL1_HUMAN 97.927 0.969697 0.30137 SLC44A1 - Choline transporter-like protein 1 - Homo sapiens (Human) - SLC44A1 gene Choline transporter. Involved in membrane synthesis and myelin production. Taurus_UMD|evm.model.AC_000165.1.710 Q9BXM9 FSD1L_HUMAN 96.349 0.987952 0.939623 FSD1L - FSD1-like protein - Homo sapiens (Human) - FSD1L gene Taurus_UMD|evm.model.AC_000165.1.711 O75072 FKTN_HUMAN 82.035 0.995338 0.930586 FKTN - Fukutin - Homo sapiens (Human) - FKTN gene Catalyzes the transfer of CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:17034757, PubMed:25279699, PubMed:26923585, PubMed:29477842). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (PubMed:17034757, PubMed:25279699, PubMed:26923585, PubMed:29477842). Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity (PubMed:17034757). May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes (PubMed:25279699). Could be involved in brain development (Probable). Taurus_UMD|evm.model.AC_000165.1.712 Q16559 TAL2_HUMAN 92.593 0.981132 0.981481 TAL2 - T-cell acute lymphocytic leukemia protein 2 - Homo sapiens (Human) - TAL2 gene chromatin, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000165.1.713 P67829 KC1A_SHEEP 96.308 0.993865 1.00308 CSNK1A1 - Casein kinase I isoform alpha - Ovis aries (Sheep) - CSNK1A1 gene Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. Taurus_UMD|evm.model.AC_000165.1.714 Q0VC58 TM38B_BOVIN 100.000 0.993151 1.00344 TMEM38B - Trimeric intracellular cation channel type B - Bos taurus (Bovine) - TMEM38B gene Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Taurus_UMD|evm.model.AC_000165.1.717 Q58DT1 RL7_BOVIN 90.826 0.972973 0.447581 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Taurus_UMD|evm.model.AC_000165.1.719 Q96JM2 ZN462_HUMAN 94.990 0.765388 0.998404 ZNF462 - Zinc finger protein 462 - Homo sapiens (Human) - ZNF462 gene Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). Taurus_UMD|evm.model.AC_000165.1.720 Q29RK4 RD23B_BOVIN 100.000 0.99511 1.00245 RAD23B - UV excision repair protein RAD23 homolog B - Bos taurus (Bovine) - RAD23B gene Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome (By similarity). Taurus_UMD|evm.model.AC_000165.1.721 Q60793 KLF4_MOUSE 92.798 0.995893 1.00828 Klf4 - Krueppel-like factor 4 - Mus musculus (Mouse) - Klf4 gene Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity). Taurus_UMD|evm.model.AC_000165.1.723 Q2KHU8 IF2G_BOVIN 98.855 0.938849 0.588983 EIF2S3 - Eukaryotic translation initiation factor 2 subunit 3 - Bos taurus (Bovine) - EIF2S3 gene As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). Taurus_UMD|evm.model.AC_000165.1.724 Q2KHU8 IF2G_BOVIN 96.429 0.834586 0.28178 EIF2S3 - Eukaryotic translation initiation factor 2 subunit 3 - Bos taurus (Bovine) - EIF2S3 gene As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). Taurus_UMD|evm.model.AC_000165.1.725 P20821 GCSH_BOVIN 92.373 0.959016 0.705202 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Taurus_UMD|evm.model.AC_000165.1.726 Q32L91 ACL7B_BOVIN 100.000 0.995215 1.0024 ACTL7B - Actin-like protein 7B - Bos taurus (Bovine) - ACTL7B gene cytoplasm, dynactin complex, nucleus Taurus_UMD|evm.model.AC_000165.1.727 Q32KZ2 ACL7A_BOVIN 100.000 0.752595 1.31963 ACTL7A - Actin-like protein 7A - Bos taurus (Bovine) - ACTL7A gene cytoplasm, dynactin complex, nucleus Taurus_UMD|evm.model.AC_000165.1.728 Q8WND5 ELP1_RABIT 86.192 0.990864 0.903226 ELP1 - Elongator complex protein 1 - Oryctolagus cuniculus (Rabbit) - ELP1 gene Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity). Taurus_UMD|evm.model.AC_000165.1.729 Q29S16 ABITM_BOVIN 100.000 0.989362 1.00535 ABITRAM - Protein Abitram - Bos taurus (Bovine) - ABITRAM gene Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons. May play a role in transcription regulation. Taurus_UMD|evm.model.AC_000165.1.730 Q5RC06 CTNL1_PONAB 92.157 0.997203 0.974114 CTNNAL1 - Alpha-catulin - Pongo abelii (Sumatran orangutan) - CTNNAL1 gene May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1). Taurus_UMD|evm.model.AC_000165.1.731 E1BD52 TM245_BOVIN 99.654 0.981818 1.01382 TMEM245 - Transmembrane protein 245 - Bos taurus (Bovine) - TMEM245 gene Taurus_UMD|evm.model.AC_000165.1.732 D3ZE85 FRS1L_RAT 96.703 0.937931 0.989761 Frrs1l - DOMON domain-containing protein FRRS1L precursor - Rattus norvegicus (Rat) - Frrs1l gene Important modulator of glutamate signaling pathway. Taurus_UMD|evm.model.AC_000165.1.733 B2RYE5 E41LB_RAT 97.011 0.479112 1.45351 Epb41l4b - Band 4.1-like protein 4B - Rattus norvegicus (Rat) - Epb41l4b gene Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18. Involved in the regulation of the circumferential actomyosin belt in epithelial cells. Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing. May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation. Taurus_UMD|evm.model.AC_000165.1.734 P26045 PTN3_HUMAN 91.005 0.892148 1.15772 PTPN3 - Tyrosine-protein phosphatase non-receptor type 3 - Homo sapiens (Human) - PTPN3 gene May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. Taurus_UMD|evm.model.AC_000165.1.736 Q8IXS6 PALM2_HUMAN 96.947 0.119595 2.86807 PALM2 - Paralemmin-2 precursor - Homo sapiens (Human) - PALM2 gene Taurus_UMD|evm.model.AC_000165.1.737 Q5JTZ5 CI152_HUMAN 69.198 0.982979 0.983264 C9orf152 - Uncharacterized protein C9orf152 - Homo sapiens (Human) - C9orf152 gene Taurus_UMD|evm.model.AC_000165.1.738 O97680 THIO_BOVIN 98.000 0.469194 2.00952 TXN - Thioredoxin - Bos taurus (Bovine) - TXN gene Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity). Taurus_UMD|evm.model.AC_000165.1.739 Q6A555 TXND8_HUMAN 55.118 0.981132 0.834646 TXNDC8 - Thioredoxin domain-containing protein 8 - Homo sapiens (Human) - TXNDC8 gene May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm. Taurus_UMD|evm.model.AC_000165.1.740 Q4LDE5 SVEP1_HUMAN 83.556 0.906635 0.953794 SVEP1 - Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 precursor - Homo sapiens (Human) - SVEP1 gene May play a role in the cell attachment process. Taurus_UMD|evm.model.AC_000165.1.741 Q8AXY6 MUSK_CHICK 87.568 0.433099 0.899683 MUSK - Muscle, skeletal receptor tyrosine protein kinase precursor - Gallus gallus (Chicken) - MUSK gene Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity). Taurus_UMD|evm.model.AC_000165.1.742 P46628 LPAR1_SHEEP 99.174 0.991781 0.928753 LPAR1 - Lysophosphatidic acid receptor 1 - Ovis aries (Sheep) - LPAR1 gene Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain. Taurus_UMD|evm.model.AC_000165.1.743 Q5VYK3 ECM29_HUMAN 96.563 0.995111 0.997832 ECPAS - Proteasome adapter and scaffold protein ECM29 - Homo sapiens (Human) - ECPAS gene Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (PubMed:15496406). Promotes proteasome dissociation under oxidative stress (By similarity). Taurus_UMD|evm.model.AC_000165.1.744 Q8TF39 ZN483_HUMAN 78.393 0.905502 1.12366 ZNF483 - Zinc finger protein 483 - Homo sapiens (Human) - ZNF483 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000165.1.745 Q3SZJ4 PTGR1_BOVIN 99.392 0.934473 1.06687 PTGR1 - Prostaglandin reductase 1 - Bos taurus (Bovine) - PTGR1 gene NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (By similarity). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). Plays a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (By similarity). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity). Taurus_UMD|evm.model.AC_000165.1.746 Q9H1X3 DJC25_HUMAN 92.222 0.994444 1 DNAJC25 - DnaJ homolog subfamily C member 25 - Homo sapiens (Human) - DNAJC25 gene endoplasmic reticulum membrane, protein folding Taurus_UMD|evm.model.AC_000165.1.747 P50151 GBG10_HUMAN 98.529 0.971014 1.01471 GNG10 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 precursor - Homo sapiens (Human) - GNG10 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3. Taurus_UMD|evm.model.AC_000165.1.748 Q5VXU9 SHOC1_HUMAN 73.371 0.998583 0.977147 SHOC1 - Protein shortage in chiasmata 1 ortholog - Homo sapiens (Human) - SHOC1 gene ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (PubMed:29742103). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (PubMed:29742103). Plays a key role in homologous recombination and crossing-over in meiotic prophase I in male and female germ cells (By similarity). Requiref for recruitment TEX11 and MSH4 to recombination intermediates (By similarity). Taurus_UMD|evm.model.AC_000165.1.749 Q16739 CEGT_HUMAN 99.746 0.994937 1.00254 UGCG - Ceramide glucosyltransferase - Homo sapiens (Human) - UGCG gene Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (PubMed:8643456, PubMed:1532799). Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures (PubMed:8643456). Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction. They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions. They are required for instance in the proper development and functioning of the nervous system. As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway. They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope. The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity). Taurus_UMD|evm.model.AC_000165.1.750 Q6UWL2 SUSD1_HUMAN 82.186 0.921271 0.96921 SUSD1 - Sushi domain-containing protein 1 precursor - Homo sapiens (Human) - SUSD1 gene Taurus_UMD|evm.model.AC_000165.1.751 O95758 PTBP3_HUMAN 96.117 0.601874 1.5471 PTBP3 - Polypyrimidine tract-binding protein 3 - Homo sapiens (Human) - PTBP3 gene RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). Taurus_UMD|evm.model.AC_000165.1.752 A4FUZ6 HSDL2_BOVIN 100.000 0.995227 1.00239 HSDL2 - Hydroxysteroid dehydrogenase-like protein 2 - Bos taurus (Bovine) - HSDL2 gene Has apparently no steroid dehydrogenase activity. Taurus_UMD|evm.model.AC_000165.1.753 Q8N8K9 K1958_HUMAN 63.636 0.910569 1.03073 KIAA1958 - Uncharacterized protein KIAA1958 - Homo sapiens (Human) - KIAA1958 gene Taurus_UMD|evm.model.AC_000165.1.754 Q8N8K9 K1958_HUMAN 96.626 0.936599 0.484637 KIAA1958 - Uncharacterized protein KIAA1958 - Homo sapiens (Human) - KIAA1958 gene Taurus_UMD|evm.model.AC_000165.1.755 Q2NKT2 SOSSC_BOVIN 100.000 0.980952 1.00962 INIP - SOSS complex subunit C - Bos taurus (Bovine) - INIP gene Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). Taurus_UMD|evm.model.AC_000165.1.756 Q5VWJ9 SNX30_HUMAN 95.881 0.995434 1.00229 SNX30 - Sorting nexin-30 - Homo sapiens (Human) - SNX30 gene May be involved in several stages of intracellular trafficking. Taurus_UMD|evm.model.AC_000165.1.757 Q9BY10 TSCOT_HUMAN 81.876 0.983087 0.995789 SLC46A2 - Thymic stromal cotransporter homolog - Homo sapiens (Human) - SLC46A2 gene May act as a transporter. Taurus_UMD|evm.model.AC_000165.1.758 Q95182 ALL1_HORSE 65.946 0.989071 0.97861 Major allergen Equ c 1 precursor - Equus caballus (Horse) Taurus_UMD|evm.model.AC_000165.1.759 Q95182 ALL1_HORSE 63.784 0.772532 1.24599 Major allergen Equ c 1 precursor - Equus caballus (Horse) Taurus_UMD|evm.model.AC_000165.1.760 Q9Y6Q3 ZFP37_HUMAN 78.362 0.99685 1.00794 ZFP37 - Zinc finger protein 37 homolog - Homo sapiens (Human) - ZFP37 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000165.1.764 O15432 COPT2_HUMAN 78.014 0.972222 1.00699 SLC31A2 - Probable low affinity copper uptake protein 2 - Homo sapiens (Human) - SLC31A2 gene Involved in low-affinity copper uptake. Taurus_UMD|evm.model.AC_000165.1.765 Q5T1M5 FKB15_HUMAN 81.848 0.998325 0.979491 FKBP15 - FK506-binding protein 15 - Homo sapiens (Human) - FKBP15 gene May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. Taurus_UMD|evm.model.AC_000165.1.766 Q8K211 COPT1_MOUSE 93.714 0.905263 0.969388 Slc31a1 - High affinity copper uptake protein 1 - Mus musculus (Mouse) - Slc31a1 gene High-affinity, saturable copper transporter involved in dietary copper uptake. Taurus_UMD|evm.model.AC_000165.1.767 Q3SZT7 CDC26_BOVIN 100.000 0.792453 1.24706 CDC26 - Anaphase-promoting complex subunit CDC26 - Bos taurus (Bovine) - CDC26 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). Taurus_UMD|evm.model.AC_000165.1.768 Q3MHE2 PRP4_BOVIN 100.000 0.996169 1.00192 PRPF4 - U4/U6 small nuclear ribonucleoprotein Prp4 - Bos taurus (Bovine) - PRPF4 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). Taurus_UMD|evm.model.AC_000165.1.769 Q29308 RS19_PIG 80.851 0.775862 0.426471 RPS19 - 40S ribosomal protein S19 - Sus scrofa (Pig) - RPS19 gene Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Taurus_UMD|evm.model.AC_000165.1.770 Q3SWY0 RN183_BOVIN 100.000 0.769547 1.29255 RNF183 - E3 ubiquitin-protein ligase RNF183 - Bos taurus (Bovine) - RNF183 gene Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling. Taurus_UMD|evm.model.AC_000165.1.771 Q8NA23 WDR31_HUMAN 86.919 0.994203 0.940054 WDR31 - WD repeat-containing protein 31 - Homo sapiens (Human) - WDR31 gene Taurus_UMD|evm.model.AC_000165.1.772 Q5W0U4 BSPRY_HUMAN 89.526 0.992556 1.00249 BSPRY - B box and SPRY domain-containing protein - Homo sapiens (Human) - BSPRY gene May regulate epithelial calcium transport by inhibiting TRPV5 activity. Taurus_UMD|evm.model.AC_000165.1.773 Q5E9D6 HDHD3_BOVIN 100.000 0.992063 1.00398 HDHD3 - Haloacid dehalogenase-like hydrolase domain-containing protein 3 - Bos taurus (Bovine) - HDHD3 gene Taurus_UMD|evm.model.AC_000165.1.774 Q58DK5 HEM2_BOVIN 100.000 0.993939 1.00304 ALAD - Delta-aminolevulinic acid dehydratase - Bos taurus (Bovine) - ALAD gene Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). Taurus_UMD|evm.model.AC_000165.1.775 Q5R4W3 DPOE3_PONAB 100.000 0.986486 1.0068 POLE3 - DNA polymerase epsilon subunit 3 - Pongo abelii (Sumatran orangutan) - POLE3 gene Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). Taurus_UMD|evm.model.AC_000165.1.776 Q8TAL5 CI043_HUMAN 55.975 0.947712 0.995662 C9orf43 - Uncharacterized protein C9orf43 - Homo sapiens (Human) - C9orf43 gene Taurus_UMD|evm.model.AC_000165.1.777 P49796 RGS3_HUMAN 86.415 0.98226 0.89399 RGS3 - Regulator of G-protein signaling 3 - Homo sapiens (Human) - RGS3 gene Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. Taurus_UMD|evm.model.AC_000165.1.778 P46405 RS12_PIG 60.902 0.98 0.757576 RPS12 - 40S ribosomal protein S12 - Sus scrofa (Pig) - RPS12 gene cytosolic small ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000165.1.780 Q5T7W0 ZN618_HUMAN 90.387 0.84 1.15304 ZNF618 - Zinc finger protein 618 - Homo sapiens (Human) - ZNF618 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000165.1.781 P00978 AMBP_BOVIN 98.864 0.994334 1.00284 AMBP - Protein AMBP precursor - Bos taurus (Bovine) - AMBP gene Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization. Taurus_UMD|evm.model.AC_000165.1.782 Q96FN5 KIF12_HUMAN 84.906 0.993721 0.986068 KIF12 - Kinesin-like protein KIF12 - Homo sapiens (Human) - KIF12 gene extracellular exosome, kinesin complex, microtubule, ATPase activity, microtubule binding, microtubule motor activity, microtubule-based movement Taurus_UMD|evm.model.AC_000165.1.783 Q8IZC6 CORA1_HUMAN 87.552 0.497568 0.773656 COL27A1 - Collagen alpha-1(XXVII) chain precursor - Homo sapiens (Human) - COL27A1 gene Plays a role during the calcification of cartilage and the transition of cartilage to bone. Taurus_UMD|evm.model.AC_000165.1.784 Q3SZR3 A1AG_BOVIN 99.505 0.990148 1.00495 ORM1 - Alpha-1-acid glycoprotein precursor - Bos taurus (Bovine) - ORM1 gene Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction (By similarity). Taurus_UMD|evm.model.AC_000165.1.785 Q7Z591 AKNA_HUMAN 75.839 0.112719 0.912439 AKNA - Microtubule organization protein AKNA - Homo sapiens (Human) - AKNA gene Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). Taurus_UMD|evm.model.AC_000165.1.786 Q9P202 WHRN_HUMAN 90.930 0.95815 1.0011 WHRN - Whirlin - Homo sapiens (Human) - WHRN gene Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Taurus_UMD|evm.model.AC_000165.1.787 P79251 VATG1_BOVIN 100.000 0.983193 1.00847 ATP6V1G1 - V-type proton ATPase subunit G 1 - Bos taurus (Bovine) - ATP6V1G1 gene Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). Taurus_UMD|evm.model.AC_000165.1.788 Q5EA48 TM268_BOVIN 100.000 0.830508 1.20058 TMEM268 - Transmembrane protein 268 - Bos taurus (Bovine) - TMEM268 gene Taurus_UMD|evm.model.AC_000165.1.789 A0A1B0GUV7 TEX48_HUMAN 47.500 0.983193 0.991667 TEX48 - Testis-expressed protein 48 - Homo sapiens (Human) - TEX48 gene Taurus_UMD|evm.model.AC_000165.1.790 O95150 TNF15_HUMAN 80.934 0.992218 1.0239 TNFSF15 - Tumor necrosis factor ligand superfamily member 15 - Homo sapiens (Human) - TNFSF15 gene Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. Taurus_UMD|evm.model.AC_000165.1.791 P32971 TNFL8_HUMAN 80.769 0.991489 1.00427 TNFSF8 - Tumor necrosis factor ligand superfamily member 8 - Homo sapiens (Human) - TNFSF8 gene Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. Taurus_UMD|evm.model.AC_000165.1.792 P24821 TENA_HUMAN 70.754 0.829769 1.0836 TNC - Tenascin precursor - Homo sapiens (Human) - TNC gene Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Taurus_UMD|evm.model.AC_000165.1.795 Q13219 PAPP1_HUMAN 82.490 0.975251 0.918869 PAPPA - Pappalysin-1 precursor - Homo sapiens (Human) - PAPPA gene Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Taurus_UMD|evm.model.AC_000165.1.796 O75129 ASTN2_HUMAN 98.796 0.972311 0.70127 ASTN2 - Astrotactin-2 precursor - Homo sapiens (Human) - ASTN2 gene Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6). Taurus_UMD|evm.model.AC_000165.1.797 Q9GL65 TLR4_BOVIN 99.881 0.997625 1.00119 TLR4 - Toll-like receptor 4 precursor - Bos taurus (Bovine) - TLR4 gene Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:17559944). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity). Activated by the signaling pathway regulator NMI which acts as damage-associated molecular patterns (DAMPs) in response to cell injury or pathogen invasion, therefore promoting nuclear factor NF-kappa-B activation (By similarity). Taurus_UMD|evm.model.AC_000165.1.800 Q5E9L2 BRNP1_BOVIN 99.869 0.997375 1.00131 BRINP1 - BMP/retinoic acid-inducible neural-specific protein 1 precursor - Bos taurus (Bovine) - BRINP1 gene Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway (By similarity). Taurus_UMD|evm.model.AC_000165.1.805 Q9BE52 CK5P2_MACFA 80.769 0.04 2.23318 CDK5RAP2 - CDK5 regulatory subunit-associated protein 2 - Macaca fascicularis (Crab-eating macaque) - CDK5RAP2 gene Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (By similarity). In complex with PDE4DIP, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery. Required for the recruitment of AKAP9 to centrosomes (By similarity). Plays a role in neurogenesis (By similarity). Taurus_UMD|evm.model.AC_000165.1.806 Q9H1U4 MEGF9_HUMAN 86.732 0.786822 0.857143 MEGF9 - Multiple epidermal growth factor-like domains protein 9 precursor - Homo sapiens (Human) - MEGF9 gene basement membrane, animal organ morphogenesis, cell migration, substrate adhesion-dependent cell spreading, tissue development Taurus_UMD|evm.model.AC_000165.1.809 Q58D00 FBXW2_BOVIN 100.000 0.80605 1.23789 FBXW2 - F-box/WD repeat-containing protein 2 - Bos taurus (Bovine) - FBXW2 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000165.1.810 A8MXE2 B3GT9_HUMAN 83.548 0.993569 0.842818 B3GALT9 - Beta-1,3-galactosyltransferase 9 - Homo sapiens (Human) - B3GALT9 gene Putative glycosyltransferase that could catalyze the transfer of galactose residues from UDP-alpha-D-galactose. Taurus_UMD|evm.model.AC_000165.1.811 Q0P5A6 PSMD5_BOVIN 99.802 0.99604 1.00398 PSMD5 - 26S proteasome non-ATPase regulatory subunit 5 - Bos taurus (Bovine) - PSMD5 gene Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity). Taurus_UMD|evm.model.AC_000165.1.812 Q7T3C3 CUTA_DANRE 52.308 0.811321 1.06 cuta - Protein CutA homolog precursor - Danio rerio (Zebrafish) - cuta gene copper ion binding Taurus_UMD|evm.model.AC_000165.1.813 Q5T6S3 PHF19_HUMAN 97.069 0.996558 1.00172 PHF19 - PHD finger protein 19 - Homo sapiens (Human) - PHF19 gene Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:15563832, PubMed:18691976, PubMed:23160351, PubMed:23228662, PubMed:23273982, PubMed:29499137, PubMed:23104054, PubMed:31959557). Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351). Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (PubMed:23104054). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter (PubMed:15563832). Taurus_UMD|evm.model.AC_000165.1.814 Q13077 TRAF1_HUMAN 88.221 0.995192 1 TRAF1 - TNF receptor-associated factor 1 - Homo sapiens (Human) - TRAF1 gene Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Taurus_UMD|evm.model.AC_000165.1.816 P01031 CO5_HUMAN 78.736 0.99699 0.99105 C5 - Complement C5 precursor - Homo sapiens (Human) - C5 gene Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Taurus_UMD|evm.model.AC_000165.1.817 Q7Z7A1 CNTRL_HUMAN 84.165 0.99101 1.00473 CNTRL - Centriolin - Homo sapiens (Human) - CNTRL gene Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. Taurus_UMD|evm.model.AC_000165.1.818 Q5R8Z8 RAB14_PONAB 100.000 0.990741 1.00465 RAB14 - Ras-related protein Rab-14 - Pongo abelii (Sumatran orangutan) - RAB14 gene Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes. Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Taurus_UMD|evm.model.AC_000165.1.821 Q3SX14 GELS_BOVIN 99.863 0.933504 1.06977 GSN - Gelsolin - Bos taurus (Bovine) - GSN gene Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). Taurus_UMD|evm.model.AC_000165.1.823 P27105 STOM_HUMAN 93.310 0.992982 0.989583 STOM - Stomatin - Homo sapiens (Human) - STOM gene Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. Taurus_UMD|evm.model.AC_000165.1.825 A8MYV0 DCD2C_HUMAN 76.056 0.775824 1.25 DCDC2C - Doublecortin domain-containing protein 2C - Homo sapiens (Human) - DCDC2C gene cytoplasm, microtubule, microtubule organizing center, sperm flagellum Taurus_UMD|evm.model.AC_000165.1.826 Q2KIG4 ALLC_BOVIN 100.000 0.995157 1.00243 ALLC - Probable allantoicase - Bos taurus (Bovine) - ALLC gene The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals. Taurus_UMD|evm.model.AC_000165.1.827 Q17QH6 COL11_BOVIN 100.000 0.992537 1.00375 COLEC11 - Collectin-11 precursor - Bos taurus (Bovine) - COLEC11 gene Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis. Taurus_UMD|evm.model.AC_000165.1.828 P62083 RS7_RAT 100.000 0.885321 1.12371 Rps7 - 40S ribosomal protein S7 - Rattus norvegicus (Rat) - Rps7 gene Required for rRNA maturation. Taurus_UMD|evm.model.AC_000165.1.829 O60930 RNH1_HUMAN 67.791 0.993769 1.12238 RNASEH1 - Ribonuclease H1 - Homo sapiens (Human) - RNASEH1 gene Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224). Taurus_UMD|evm.model.AC_000165.1.830 Q3ZBL1 MTND_BOVIN 100.000 0.988889 1.00559 ADI1 - 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase - Bos taurus (Bovine) - ADI1 gene Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Taurus_UMD|evm.model.AC_000165.1.831 Q8K2L8 TPC12_MOUSE 75.689 0.997468 0.991217 Trappc12 - Trafficking protein particle complex subunit 12 - Mus musculus (Mouse) - Trappc12 gene Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores. Taurus_UMD|evm.model.AC_000165.1.832 Q53HC9 EIPR1_HUMAN 88.889 0.994845 1.00258 EIPR1 - EARP and GARP complex-interacting protein 1 - Homo sapiens (Human) - EIPR1 gene Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (PubMed:27440922). Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein(PubMed:27440922). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (PubMed:27440922). Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity). Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity). Taurus_UMD|evm.model.AC_000166.1.2 Q13136 LIPA1_HUMAN 50.404 0.920255 0.521631 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000166.1.3 Q2TL32 UBR4_RAT 87.719 0.622222 0.0173277 Ubr4 - E3 ubiquitin-protein ligase UBR4 - Rattus norvegicus (Rat) - Ubr4 gene E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation (By similarity). Taurus_UMD|evm.model.AC_000166.1.4 Q6ZPY2 SMG5_MOUSE 42.308 0.283883 0.536873 Smg5 - Protein SMG5 - Mus musculus (Mouse) - Smg5 gene Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity (By similarity). Taurus_UMD|evm.model.AC_000166.1.5 P19633 CASQ1_RAT 79.111 0.919811 0.522167 Casq1 - Calsequestrin-1 precursor - Rattus norvegicus (Rat) - Casq1 gene Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:8042990). Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction (By similarity). Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity). Taurus_UMD|evm.model.AC_000166.1.6 Q78EG7 TP4A1_RAT 98.266 0.988506 1.00578 Ptp4a1 - Protein tyrosine phosphatase type IVA 1 precursor - Rattus norvegicus (Rat) - Ptp4a1 gene Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). Taurus_UMD|evm.model.AC_000166.1.7 Q92576 PHF3_HUMAN 82.364 0.978723 1.01422 PHF3 - PHD finger protein 3 - Homo sapiens (Human) - PHF3 gene multicellular organism development Taurus_UMD|evm.model.AC_000166.1.8 P35293 RAB18_MOUSE 98.235 0.988304 0.830097 Rab18 - Ras-related protein Rab-18 precursor - Mus musculus (Mouse) - Rab18 gene Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (By similarity). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (By similarity). Taurus_UMD|evm.model.AC_000166.1.10 P60509 ERB1_HUMAN 33.908 0.835052 0.377432 ERVPABLB-1 - Endogenous retrovirus group PABLB member 1 Env polyprotein - Homo sapiens (Human) - ERVPABLB-1 gene Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. Taurus_UMD|evm.model.AC_000166.1.11 Q96J02 ITCH_HUMAN 94.052 0.370474 0.795127 ITCH - E3 ubiquitin-protein ligase Itchy homolog - Homo sapiens (Human) - ITCH gene Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14602072, PubMed:17028573, PubMed:16387660, PubMed:18718448, PubMed:18718449, PubMed:11046148, PubMed:19592251, PubMed:19116316, PubMed:19881509, PubMed:20491914, PubMed:20392206, PubMed:20068034, PubMed:23146885, PubMed:24790097, PubMed:25631046). Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (PubMed:17028573, PubMed:18718448, PubMed:19131965, PubMed:19881509). Involved in the control of inflammatory signaling pathways (PubMed:19131965). Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (PubMed:19131965). Promotes the association of the complex after TNF stimulation (PubMed:19131965). Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:19131965). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (PubMed:19131965). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (PubMed:19592251). Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response (PubMed:18718448, PubMed:20491914). Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages (PubMed:18718448). Mediates JUN ubiquitination and degradation (By similarity). Mediates JUNB ubiquitination and degradation (PubMed:16387660). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (By similarity). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (PubMed:19881509). Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (PubMed:19881509). Following ligand stimulation, regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (PubMed:23146885). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (PubMed:23146885). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:14602072, PubMed:23146885). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:17028573, PubMed:18628966, PubMed:23886940). Ubiquitinates SNX9 (PubMed:20491914). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (By similarity). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (PubMed:20068034). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Inhibits the replication of influenza A virus (IAV) via ubiquitination of IAV matrix protein 1 (M1) through 'Lys-48'-linked conjugation resulting in M1 proteasomal degradation (PubMed:30328013). Taurus_UMD|evm.model.AC_000166.1.12 Q3V3Q4 PYDC3_MOUSE 42.623 0.379747 0.268707 Pydc3 - Pyrin domain-containing protein 3 - Mus musculus (Mouse) - Pydc3 gene cytosol, nucleolus, nucleoplasm, nucleus, DNA-binding transcription repressor activity, RNA polymerase II-specific, double-stranded DNA binding, identical protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, transcription factor binding, cellular response to interferon-beta Taurus_UMD|evm.model.AC_000166.1.15 Q9BUJ2 HNRL1_HUMAN 68.182 0.833333 0.0911215 HNRNPUL1 - Heterogeneous nuclear ribonucleoprotein U-like protein 1 - Homo sapiens (Human) - HNRNPUL1 gene Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. Taurus_UMD|evm.model.AC_000166.1.16 Q02377 NDUA1_BOVIN 96.000 0.960784 0.728571 NDUFA1 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 - Bos taurus (Bovine) - NDUFA1 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000166.1.17 Q6DG32 S2536_DANRE 83.333 0.337209 0.276527 slc25a36a - Solute carrier family 25 member 36-A - Danio rerio (Zebrafish) - slc25a36a gene pyrimidine nucleotide transmembrane transporter activity, pyrimidine nucleotide import into mitochondrion Taurus_UMD|evm.model.AC_000166.1.18 P61078 UB2D3_RAT 95.238 0.986486 1.0068 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Taurus_UMD|evm.model.AC_000166.1.19 Q80ZF8 AGRB3_MOUSE 98.413 0.90942 0.18134 Adgrb3 - Adhesion G protein-coupled receptor B3 precursor - Mus musculus (Mouse) - Adgrb3 gene Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (PubMed:23628982). Promotes myoblast fusion through ELMO/DOCK1 (By similarity). Taurus_UMD|evm.model.AC_000166.1.20 P09456 KAP0_RAT 71.552 0.611702 0.493438 Prkar1a - cAMP-dependent protein kinase type I-alpha regulatory subunit - Rattus norvegicus (Rat) - Prkar1a gene Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Taurus_UMD|evm.model.AC_000166.1.21 A8D8X1 RL10_SHEEP 57.485 0.984962 0.621495 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000166.1.22 P13549 EF1A0_XENLA 77.838 0.978723 0.406926 eef1as - Elongation factor 1-alpha, somatic form - Xenopus laevis (African clawed frog) - eef1as gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Taurus_UMD|evm.model.AC_000166.1.23 P68105 EF1A1_RABIT 93.333 0.992188 0.554113 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000166.1.25 O60242 AGRB3_HUMAN 98.129 0.997126 0.457293 ADGRB3 - Adhesion G protein-coupled receptor B3 precursor - Homo sapiens (Human) - ADGRB3 gene Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399). Taurus_UMD|evm.model.AC_000166.1.26 Q5E9E2 MYL9_BOVIN 79.310 0.876923 0.755814 MYL9 - Myosin regulatory light polypeptide 9 - Bos taurus (Bovine) - MYL9 gene Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity). Taurus_UMD|evm.model.AC_000166.1.27 Q3SYY9 LMBD1_BOVIN 85.451 0.995708 0.858195 LMBRD1 - Lysosomal cobalamin transport escort protein LMBD1 - Bos taurus (Bovine) - LMBRD1 gene Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity). Taurus_UMD|evm.model.AC_000166.1.29 Q14993 COJA1_HUMAN 66.270 0.756098 0.287215 COL19A1 - Collagen alpha-1(XIX) chain precursor - Homo sapiens (Human) - COL19A1 gene May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. Taurus_UMD|evm.model.AC_000166.1.30 Q14993 COJA1_HUMAN 84.828 0.927461 0.676007 COL19A1 - Collagen alpha-1(XIX) chain precursor - Homo sapiens (Human) - COL19A1 gene May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. Taurus_UMD|evm.model.AC_000166.1.31 P20849 CO9A1_HUMAN 91.886 0.924797 0.534202 COL9A1 - Collagen alpha-1(IX) chain precursor - Homo sapiens (Human) - COL9A1 gene Structural component of hyaline cartilage and vitreous of the eye. Taurus_UMD|evm.model.AC_000166.1.32 P20849 CO9A1_HUMAN 90.385 0.687003 0.409338 COL9A1 - Collagen alpha-1(IX) chain precursor - Homo sapiens (Human) - COL9A1 gene Structural component of hyaline cartilage and vitreous of the eye. Taurus_UMD|evm.model.AC_000166.1.33 Q99880 H2B1L_HUMAN 89.683 0.984252 1.00794 H2BC13 - Histone H2B type 1-L - Homo sapiens (Human) - H2BC13 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000166.1.35 Q9P2D6 F135A_HUMAN 86.537 0.998706 1.0198 FAM135A - Protein FAM135A - Homo sapiens (Human) - FAM135A gene cellular lipid metabolic process Taurus_UMD|evm.model.AC_000166.1.36 Q5VUM1 SDHF4_HUMAN 84.466 0.625 1.48148 SDHAF4 - Succinate dehydrogenase assembly factor 4, mitochondrial precursor - Homo sapiens (Human) - SDHAF4 gene Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity). Taurus_UMD|evm.model.AC_000166.1.37 Q8IYB5 SMAP1_HUMAN 86.229 0.995763 1.01071 SMAP1 - Stromal membrane-associated protein 1 - Homo sapiens (Human) - SMAP1 gene GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity). Taurus_UMD|evm.model.AC_000166.1.38 Q5CAZ6 B3GA2_CANLF 93.030 0.993884 0.993921 B3GAT2 - Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 - Canis lupus familiaris (Dog) - B3GAT2 gene Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Taurus_UMD|evm.model.AC_000166.1.39 Q5TC84 OGRL1_HUMAN 82.385 0.963255 0.844789 OGFRL1 - Opioid growth factor receptor-like protein 1 - Homo sapiens (Human) - OGFRL1 gene Taurus_UMD|evm.model.AC_000166.1.41 Q86UR5 RIMS1_HUMAN 93.878 0.751938 0.0762411 RIMS1 - Regulating synaptic membrane exocytosis protein 1 - Homo sapiens (Human) - RIMS1 gene Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Taurus_UMD|evm.model.AC_000166.1.42 Q9JIR4 RIMS1_RAT 88.761 0.998016 0.624149 Rims1 - Regulating synaptic membrane exocytosis protein 1 - Rattus norvegicus (Rat) - Rims1 gene Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Plays a role in dendrite formation by melanocytes. Taurus_UMD|evm.model.AC_000166.1.43 P56696 KCNQ4_HUMAN 81.481 0.265306 0.141007 KCNQ4 - Potassium voltage-gated channel subfamily KQT member 4 - Homo sapiens (Human) - KCNQ4 gene Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors. Taurus_UMD|evm.model.AC_000166.1.46 Q9JK45 KCNQ5_MOUSE 83.804 0.781847 0.673098 Kcnq5 - Potassium voltage-gated channel subfamily KQT member 5 - Mus musculus (Mouse) - Kcnq5 gene Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Taurus_UMD|evm.model.AC_000166.1.47 Q5JSQ8 KHDCL_HUMAN 49.275 0.455782 1.14844 KHDC1L - Putative KHDC1-like protein - Homo sapiens (Human) - KHDC1L gene cytoplasm, RNA binding, activation of cysteine-type endopeptidase activity involved in apoptotic process Taurus_UMD|evm.model.AC_000166.1.49 Q587J8 KHDC3_HUMAN 60.563 0.505967 1.93088 KHDC3L - KH domain-containing protein 3 - Homo sapiens (Human) - KHDC3L gene As part of the OOEP-KHDC3L scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Involved in the repair of DNA double strand breaks independent of its role in restarting stalled replication forks (By similarity). As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for maintenance of euploidy during cleavage-stage embryogenesis (By similarity). Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process (By similarity). Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (By similarity). Capable of binding RNA (By similarity). Taurus_UMD|evm.model.AC_000166.1.50 A0JNQ6 OOEP_BOVIN 100.000 0.985816 1.00714 OOEP - Oocyte-expressed protein homolog - Bos taurus (Bovine) - OOEP gene As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes (By similarity). Thereby contributes to oocyte survival and the resumption and completion of meiosis (By similarity). As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). Taurus_UMD|evm.model.AC_000166.1.51 Q9NXZ2 DDX43_HUMAN 71.341 0.995342 0.993827 DDX43 - Probable ATP-dependent RNA helicase DDX43 - Homo sapiens (Human) - DDX43 gene RNA binding, RNA helicase activity Taurus_UMD|evm.model.AC_000166.1.53 E1BGN7 CGAS_BOVIN 99.564 0.867424 1.06024 CGAS - Cyclic GMP-AMP synthase - Bos taurus (Bovine) - CGAS gene Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Preferentially binds long dsDNA (around 45 bp) and forms ladder-like networks that function cooperatively to stabilize individual cGAS-dsDNA complexes. Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm. Also acts as an innate immune sensor of infection by retroviruses by detecting the presence of reverse-transcribed DNA in the cytosol (By similarity). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (By similarity). Also detects the presence of DNA from bacteria (By similarity). cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote TMEM173/STING activation and convey immune response to connecting cells. cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner. In addition to antiviral activity, also involved in the response to cellular stresses, such as senescence, DNA damage or genome instability. Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via TMEM173/STING and promote cellular senescence. Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability. Micronuclei, which as frequently found in cancer cells, consist of chromatin surrounded by its own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to cGAMP synthesis and subsequent activation of TMEM173/STING and type-I interferon production (By similarity). Acts as a suppressor of DNA repair in response to DNA damage: translocates to the nucleus following dephosphorylation at Tyr-204 and inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (By similarity). Taurus_UMD|evm.model.AC_000166.1.54 Q4R4P6 MTO1_MACFA 89.162 0.997114 1.00145 MTO1 - Protein MTO1 homolog, mitochondrial precursor - Macaca fascicularis (Crab-eating macaque) - MTO1 gene Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Taurus_UMD|evm.model.AC_000166.1.55 P68105 EF1A1_RABIT 100.000 0.99568 1.00216 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000166.1.56 Q9MZD1 S17A5_SHEEP 97.778 0.995968 1.00202 SLC17A5 - Sialin - Ovis aries (Sheep) - SLC17A5 gene Primary solute translocator for anionic substances; particularly it is a free sialic acid transporter in the lysosomes (Probable). Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties. Taurus_UMD|evm.model.AC_000166.1.57 Q6YHK3 CD109_HUMAN 82.546 0.997921 0.998616 CD109 - CD109 antigen precursor - Homo sapiens (Human) - CD109 gene Modulates negatively TGFB1 signaling in keratinocytes. Taurus_UMD|evm.model.AC_000166.1.59 Q99715 COCA1_HUMAN 93.599 0.982247 1.01143 COL12A1 - Collagen alpha-1(XII) chain precursor - Homo sapiens (Human) - COL12A1 gene Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. Taurus_UMD|evm.model.AC_000166.1.60 Q17QL5 CC50A_BOVIN 100.000 0.652913 1.14127 TMEM30A - Cell cycle control protein 50A - Bos taurus (Bovine) - TMEM30A gene Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF). Can also mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations. Taurus_UMD|evm.model.AC_000166.1.61 Q7Z7B0 FLIP1_HUMAN 94.889 0.974277 1.02556 FILIP1 - Filamin-A-interacting protein 1 - Homo sapiens (Human) - FILIP1 gene By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. Taurus_UMD|evm.model.AC_000166.1.64 P18621 RL17_HUMAN 88.158 0.974026 0.418478 RPL17 - 60S ribosomal protein L17 - Homo sapiens (Human) - RPL17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000166.1.66 Q9GZR1 SENP6_HUMAN 84.595 0.998255 1.03058 SENP6 - Sentrin-specific protease 6 - Homo sapiens (Human) - SENP6 gene Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. Taurus_UMD|evm.model.AC_000166.1.67 Q9BXY8 BEX2_HUMAN 77.273 0.68254 0.492188 BEX2 - Protein BEX2 - Homo sapiens (Human) - BEX2 gene Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity. Taurus_UMD|evm.model.AC_000166.1.68 E1BPK6 MYO6_BOVIN 100.000 0.998457 1.00077 MYO6 - Unconventional myosin-VI - Bos taurus (Bovine) - MYO6 gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (By similarity). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Modulates RNA polymerase II-dependent transcription (By similarity). Taurus_UMD|evm.model.AC_000166.1.69 Q9GMS5 IMPG1_BOVIN 93.981 0.981651 0.274559 IMPG1 - Interphotoreceptor matrix proteoglycan 1 precursor - Bos taurus (Bovine) - IMPG1 gene Chondroitin sulfate-, heparin- and hyaluronan-binding protein (By similarity). May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix (By similarity). Taurus_UMD|evm.model.AC_000166.1.70 Q9GMS5 IMPG1_BOVIN 86.286 0.809976 0.530227 IMPG1 - Interphotoreceptor matrix proteoglycan 1 precursor - Bos taurus (Bovine) - IMPG1 gene Chondroitin sulfate-, heparin- and hyaluronan-binding protein (By similarity). May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix (By similarity). Taurus_UMD|evm.model.AC_000166.1.71 P62936 PPIA_PIG 84.932 0.430303 1.0061 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Taurus_UMD|evm.model.AC_000166.1.72 P61928 RL37_RAT 97.938 0.979592 1.01031 Rpl37 - 60S ribosomal protein L37 - Rattus norvegicus (Rat) - Rpl37 gene Binds to the 23S rRNA. Taurus_UMD|evm.model.AC_000166.1.75 P79250 5HT1B_CANLF 91.755 0.923267 1.03856 HTR1B - 5-hydroxytryptamine receptor 1B - Canis lupus familiaris (Dog) - HTR1B gene G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries (By similarity). Taurus_UMD|evm.model.AC_000166.1.76 A8MW99 MEI4_HUMAN 64.211 0.749004 0.651948 MEI4 - Meiosis-specific protein MEI4 - Homo sapiens (Human) - MEI4 gene Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Taurus_UMD|evm.model.AC_000166.1.77 P23004 QCR2_BOVIN 98.896 0.995595 1.00221 UQCRC2 - Cytochrome b-c1 complex subunit 2, mitochondrial precursor - Bos taurus (Bovine) - UQCRC2 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (PubMed:9694818, PubMed:11073949). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Taurus_UMD|evm.model.AC_000166.1.79 Q5VVH5 IKBP1_HUMAN 87.692 0.992337 1.00385 IRAK1BP1 - Interleukin-1 receptor-associated kinase 1-binding protein 1 - Homo sapiens (Human) - IRAK1BP1 gene Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity). Taurus_UMD|evm.model.AC_000166.1.81 Q8WWQ0 PHIP_HUMAN 96.025 0.964384 1.0022 PHIP - PH-interacting protein - Homo sapiens (Human) - PHIP gene Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Taurus_UMD|evm.model.AC_000166.1.82 Q3ZBV4 HMGN3_BOVIN 100.000 0.980198 1.01 HMGN3 - High mobility group nucleosome-binding domain-containing protein 3 - Bos taurus (Bovine) - HMGN3 gene Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). Taurus_UMD|evm.model.AC_000166.1.83 Q86VQ0 LCA5_HUMAN 56.143 0.996753 0.883788 LCA5 - Lebercilin - Homo sapiens (Human) - LCA5 gene Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. Taurus_UMD|evm.model.AC_000166.1.84 A4IFC4 SH3L2_BOVIN 97.895 0.648276 1.35514 SH3BGRL2 - SH3 domain-binding glutamic acid-rich-like protein 2 - Bos taurus (Bovine) - SH3BGRL2 gene Taurus_UMD|evm.model.AC_000166.1.85 Q3S8M4 ELOV4_MACMU 92.038 0.993651 1.00318 ELOVL4 - Elongation of very long chain fatty acids protein 4 - Macaca mulatta (Rhesus macaque) - ELOVL4 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. Taurus_UMD|evm.model.AC_000166.1.86 P33981 TTK_HUMAN 75.314 0.997599 0.971995 TTK - Dual specificity protein kinase TTK - Homo sapiens (Human) - TTK gene Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720). Probably associated with cell proliferation (PubMed:18243099). Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720). Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099). Taurus_UMD|evm.model.AC_000166.1.87 P21953 ODBB_HUMAN 98.000 0.9 0.280612 BCKDHB - 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor - Homo sapiens (Human) - BCKDHB gene The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Taurus_UMD|evm.model.AC_000166.1.88 P21839 ODBB_BOVIN 100.000 0.315271 0.517857 BCKDHB - 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor - Bos taurus (Bovine) - BCKDHB gene The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Taurus_UMD|evm.model.AC_000166.1.89 P21839 ODBB_BOVIN 100.000 0.903614 0.211735 BCKDHB - 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor - Bos taurus (Bovine) - BCKDHB gene The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Taurus_UMD|evm.model.AC_000166.1.91 Q96IP4 TET5A_HUMAN 95.249 0.995402 0.984163 TENT5A - Terminal nucleotidyltransferase 5A - Homo sapiens (Human) - TENT5A gene Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase. Taurus_UMD|evm.model.AC_000166.1.93 Q1RMW1 UBE2F_BOVIN 64.286 0.482353 0.459459 UBE2F - NEDD8-conjugating enzyme UBE2F - Bos taurus (Bovine) - UBE2F gene Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. Taurus_UMD|evm.model.AC_000166.1.94 Q9P2D0 IBTK_HUMAN 90.399 0.954802 1.04656 IBTK - Inhibitor of Bruton tyrosine kinase - Homo sapiens (Human) - IBTK gene Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. Taurus_UMD|evm.model.AC_000166.1.97 Q13641 TPBG_HUMAN 86.905 0.995249 1.00238 TPBG - Trophoblast glycoprotein precursor - Homo sapiens (Human) - TPBG gene May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. Taurus_UMD|evm.model.AC_000166.1.98 Q1JQA1 UBE3D_BOVIN 100.000 0.994872 1.00257 UBE3D - E3 ubiquitin-protein ligase E3D - Bos taurus (Bovine) - UBE3D gene E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Taurus_UMD|evm.model.AC_000166.1.99 Q5JWR5 DOP1_HUMAN 94.567 0.999195 1.00852 DOP1A - Protein dopey-1 - Homo sapiens (Human) - DOP1A gene May be involved in protein traffic between late Golgi and early endosomes. Taurus_UMD|evm.model.AC_000166.1.100 F1RQM2 AGM1_PIG 88.930 0.747238 1.33579 PGM3 - Phosphoacetylglucosamine mutase - Sus scrofa (Pig) - PGM3 gene Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. Taurus_UMD|evm.model.AC_000166.1.101 Q9UIY3 RWD2A_HUMAN 95.548 0.993174 1.00342 RWDD2A - RWD domain-containing protein 2A - Homo sapiens (Human) - RWDD2A gene Taurus_UMD|evm.model.AC_000166.1.102 Q29558 MAOX_PIG 93.175 0.988235 0.610413 ME1 - NADP-dependent malic enzyme - Sus scrofa (Pig) - ME1 gene cytosol, mitochondrion, malate dehydrogenase (decarboxylating) (NADP+) activity, malic enzyme activity, manganese ion binding, malate metabolic process, pyruvate metabolic process, response to hormone Taurus_UMD|evm.model.AC_000166.1.103 Q29558 MAOX_PIG 95.041 0.967742 0.222621 ME1 - NADP-dependent malic enzyme - Sus scrofa (Pig) - ME1 gene cytosol, mitochondrion, malate dehydrogenase (decarboxylating) (NADP+) activity, malic enzyme activity, manganese ion binding, malate metabolic process, pyruvate metabolic process, response to hormone Taurus_UMD|evm.model.AC_000166.1.104 Q5E9X7 PRS35_BOVIN 100.000 0.995157 1.00243 PRSS35 - Inactive serine protease 35 precursor - Bos taurus (Bovine) - PRSS35 gene Taurus_UMD|evm.model.AC_000166.1.105 O60641 AP180_HUMAN 99.160 0.576547 0.676957 SNAP91 - Clathrin coat assembly protein AP180 - Homo sapiens (Human) - SNAP91 gene Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity). Taurus_UMD|evm.model.AC_000166.1.106 Q6P5S2 LEG1H_HUMAN 64.590 0.980645 0.939394 LEG1 - Protein LEG1 homolog precursor - Homo sapiens (Human) - LEG1 gene May be involved in early liver development. Taurus_UMD|evm.model.AC_000166.1.107 Q5TF21 SOGA3_HUMAN 93.075 0.997897 1.00422 SOGA3 - Protein SOGA3 precursor - Homo sapiens (Human) - SOGA3 gene Taurus_UMD|evm.model.AC_000166.1.108 Q6ZU52 K0408_HUMAN 71.758 0.997118 1 KIAA0408 - Uncharacterized protein KIAA0408 - Homo sapiens (Human) - KIAA0408 gene Taurus_UMD|evm.model.AC_000166.1.109 Q2HJD5 ECHD1_BOVIN 100.000 0.993355 0.98366 ECHDC1 - Ethylmalonyl-CoA decarboxylase - Bos taurus (Bovine) - ECHDC1 gene Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level. Taurus_UMD|evm.model.AC_000166.1.110 Q3T139 R146B_BOVIN 100.000 0.994236 1 RNF146B - E3 ubiquitin-protein ligase RNF146-B - Bos taurus (Bovine) - RNF146B gene E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination (By similarity). Taurus_UMD|evm.model.AC_000166.1.112 Q1RMU1 RSPO3_BOVIN 100.000 0.990244 0.750916 RSPO3 - R-spondin-3 precursor - Bos taurus (Bovine) - RSPO3 gene Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (By similarity). Taurus_UMD|evm.model.AC_000166.1.113 Q71SV0 LAP4B_BOVIN 90.769 0.977273 0.584071 LAPTM4B - Lysosomal-associated transmembrane protein 4B - Bos taurus (Bovine) - LAPTM4B gene Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways. Taurus_UMD|evm.model.AC_000166.1.114 A8E4M4 MCRI1_BOVIN 90.722 0.979592 1.01031 MCRIP1 - Mapk-regulated corepressor-interacting protein 1 - Bos taurus (Bovine) - MCRIP1 gene The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition. Taurus_UMD|evm.model.AC_000166.1.115 Q5EE01 CENPW_HUMAN 86.364 0.977528 1.01136 CENPW - Centromere protein W - Homo sapiens (Human) - CENPW gene Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. Taurus_UMD|evm.model.AC_000166.1.116 Q05B63 TRM11_BOVIN 100.000 0.995662 1.00217 TRMT11 - tRNA (guanine(10)-N2)-methyltransferase homolog - Bos taurus (Bovine) - TRMT11 gene Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. Taurus_UMD|evm.model.AC_000166.1.117 Q2YDJ4 HINT3_BOVIN 100.000 0.989071 1.00549 HINT3 - Histidine triad nucleotide-binding protein 3 - Bos taurus (Bovine) - HINT3 gene Hydrolyzes phosphoramidate and acyl-adenylate substrates. Taurus_UMD|evm.model.AC_000166.1.118 Q8NI08 NCOA7_HUMAN 88.653 0.997872 0.997877 NCOA7 - Nuclear receptor coactivator 7 - Homo sapiens (Human) - NCOA7 gene Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. Taurus_UMD|evm.model.AC_000166.1.119 Q9UBP5 HEY2_HUMAN 98.220 0.994083 1.00297 HEY2 - Hairy/enhancer-of-split related with YRPW motif protein 2 - Homo sapiens (Human) - HEY2 gene Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Taurus_UMD|evm.model.AC_000166.1.120 Q13439 GOGA4_HUMAN 89.130 0.963158 0.0852018 GOLGA4 - Golgin subfamily A member 4 - Homo sapiens (Human) - GOLGA4 gene Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). Taurus_UMD|evm.model.AC_000166.1.121 Q0P565 HDDC2_BOVIN 100.000 0.990291 1.00488 HDDC2 - 5'-deoxynucleotidase HDDC2 - Bos taurus (Bovine) - HDDC2 gene Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP). Taurus_UMD|evm.model.AC_000166.1.122 Q16890 TPD53_HUMAN 89.474 0.990476 1.02941 TPD52L1 - Tumor protein D53 - Homo sapiens (Human) - TPD52L1 gene cytoplasm, perinuclear region of cytoplasm, identical protein binding, protein homodimerization activity, G2/M transition of mitotic cell cycle, positive regulation of apoptotic signaling pathway, positive regulation of JNK cascade, positive regulation of MAP kinase activity Taurus_UMD|evm.model.AC_000166.1.123 Q8TC41 RN217_HUMAN 92.111 0.983982 0.806273 RNF217 - Probable E3 ubiquitin-protein ligase RNF217 - Homo sapiens (Human) - RNF217 gene E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Taurus_UMD|evm.model.AC_000166.1.124 Q2NL29 INO1_BOVIN 40.000 0.854093 0.504488 ISYNA1 - Inositol-3-phosphate synthase 1 - Bos taurus (Bovine) - ISYNA1 gene Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). Taurus_UMD|evm.model.AC_000166.1.127 Q4R5Y8 UB2G1_MACFA 48.148 0.158416 1.78235 UBE2G1 - Ubiquitin-conjugating enzyme E2 G1 - Macaca fascicularis (Crab-eating macaque) - UBE2G1 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4. Taurus_UMD|evm.model.AC_000166.1.128 P82179 TRDN_CANLF 84.314 0.124384 1.15835 TRDN - Triadin - Canis lupus familiaris (Dog) - TRDN gene Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. Taurus_UMD|evm.model.AC_000166.1.130 Q71U00 SKP1_XENLA 96.933 0.987578 0.98773 skp1 - S-phase kinase-associated protein 1 - Xenopus laevis (African clawed frog) - skp1 gene Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). Taurus_UMD|evm.model.AC_000166.1.131 Q95KF7 CLVS2_MACFA 99.694 0.993902 1.00306 CLVS2 - Clavesin-2 - Macaca fascicularis (Crab-eating macaque) - CLVS2 gene Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Taurus_UMD|evm.model.AC_000166.1.133 Q3ZC91 ASM3A_BOVIN 99.556 0.995565 1.00222 SMPDL3A - Acid sphingomyelinase-like phosphodiesterase 3a precursor - Bos taurus (Bovine) - SMPDL3A gene Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity. Taurus_UMD|evm.model.AC_000166.1.134 Q09139 FABP7_BOVIN 100.000 0.984962 1.00758 FABP7 - Fatty acid-binding protein, brain - Bos taurus (Bovine) - FABP7 gene FABP are thought to play a role in the intracellular transport of long chain fatty acids and their acyl-CoA esters. Binds oleic and palmitic acids but not palmitoyl CoA. Taurus_UMD|evm.model.AC_000166.1.135 Q9C010 IPKB_HUMAN 73.611 0.972603 0.935897 PKIB - cAMP-dependent protein kinase inhibitor beta - Homo sapiens (Human) - PKIB gene Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Taurus_UMD|evm.model.AC_000166.1.136 Q3MHV9 SERC1_BOVIN 98.013 0.995506 0.98234 SERINC1 - Serine incorporator 1 - Bos taurus (Bovine) - SERINC1 gene Enhances the incorporation of serine into phosphatidylserine and sphingolipids. Taurus_UMD|evm.model.AC_000166.1.137 Q03933 HSF2_HUMAN 94.590 0.996132 0.964552 HSF2 - Heat shock factor protein 2 - Homo sapiens (Human) - HSF2 gene DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. Taurus_UMD|evm.model.AC_000166.1.138 Q8HXB8 RL29_MACFA 75.000 0.964286 0.356688 RPL29 - 60S ribosomal protein L29 - Macaca fascicularis (Crab-eating macaque) - RPL29 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000166.1.139 P18246 CXA1_BOVIN 100.000 0.994792 1.00261 GJA1 - Gap junction alpha-1 protein - Bos taurus (Bovine) - GJA1 gene Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). Taurus_UMD|evm.model.AC_000166.1.140 Q96NH3 BROMI_HUMAN 90.977 0.22534 0.935561 TBC1D32 - Protein broad-minded - Homo sapiens (Human) - TBC1D32 gene Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity). Taurus_UMD|evm.model.AC_000166.1.141 Q8N335 GPD1L_HUMAN 88.319 0.994318 1.00285 GPD1L - Glycerol-3-phosphate dehydrogenase 1-like protein - Homo sapiens (Human) - GPD1L gene Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. Taurus_UMD|evm.model.AC_000166.1.143 O02773 MA1A1_PIG 91.994 0.99697 1.00152 MAN1A1 - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA - Sus scrofa (Pig) - MAN1A1 gene Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). Taurus_UMD|evm.model.AC_000166.1.144 Q8NB25 F184A_HUMAN 94.386 0.998247 1.00088 FAM184A - Protein FAM184A - Homo sapiens (Human) - FAM184A gene extracellular space Taurus_UMD|evm.model.AC_000166.1.145 F1N2W9 MCM9_BOVIN 100.000 0.303951 0.86655 MCM9 - DNA helicase MCM9 - Bos taurus (Bovine) - MCM9 gene Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand. In addition, recruits MLH1, a component of the MMR complex, to chromatin. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. Probably by regulating HR, plays a key role during gametogenesis. Taurus_UMD|evm.model.AC_000166.1.146 Q5SZL2 CE85L_HUMAN 90.087 0.997522 1.00248 CEP85L - Centrosomal protein of 85 kDa-like - Homo sapiens (Human) - CEP85L gene Plays an essential role in neuronal cell migration. Taurus_UMD|evm.model.AC_000166.1.147 P26882 PPID_BOVIN 92.035 0.982456 0.308108 PPID - Peptidyl-prolyl cis-trans isomerase D - Bos taurus (Bovine) - PPID gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Taurus_UMD|evm.model.AC_000166.1.148 P26882 PPID_BOVIN 88.421 0.979167 0.259459 PPID - Peptidyl-prolyl cis-trans isomerase D - Bos taurus (Bovine) - PPID gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Taurus_UMD|evm.model.AC_000166.1.149 Q5T1Q4 S35F1_HUMAN 98.571 0.994302 0.860294 SLC35F1 - Solute carrier family 35 member F1 - Homo sapiens (Human) - SLC35F1 gene Putative solute transporter. Taurus_UMD|evm.model.AC_000166.1.150 Q5T1Q4 S35F1_HUMAN 92.500 0.513514 0.181373 SLC35F1 - Solute carrier family 35 member F1 - Homo sapiens (Human) - SLC35F1 gene Putative solute transporter. Taurus_UMD|evm.model.AC_000166.1.151 P47914 RL29_HUMAN 56.122 0.442396 1.36478 RPL29 - 60S ribosomal protein L29 - Homo sapiens (Human) - RPL29 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000166.1.152 Q96E22 NGBR_HUMAN 95.683 0.826347 0.569966 NUS1 - Dehydrodolichyl diphosphate synthase complex subunit NUS1 - Homo sapiens (Human) - NUS1 gene With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300). Taurus_UMD|evm.model.AC_000166.1.153 Q9CQ76 NEPN_MOUSE 83.301 0.990253 1.00195 Nepn - Nephrocan precursor - Mus musculus (Mouse) - Nepn gene May inhibit TGF-beta signaling. Taurus_UMD|evm.model.AC_000166.1.154 Q9HD26 GOPC_HUMAN 96.404 0.956897 1.00433 GOPC - Golgi-associated PDZ and coiled-coil motif-containing protein - Homo sapiens (Human) - GOPC gene Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. Taurus_UMD|evm.model.AC_000166.1.155 Q8N8Z6 DCBD1_HUMAN 81.988 0.962025 0.994406 DCBLD1 - Discoidin, CUB and LCCL domain-containing protein 1 precursor - Homo sapiens (Human) - DCBLD1 gene Taurus_UMD|evm.model.AC_000166.1.156 P08922 ROS1_HUMAN 83.594 0.999147 0.999148 ROS1 - Proto-oncogene tyrosine-protein kinase ROS precursor - Homo sapiens (Human) - ROS1 gene Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. Taurus_UMD|evm.model.AC_000166.1.157 Q8N8G2 VGLL2_HUMAN 92.484 0.950156 1.01262 VGLL2 - Transcription cofactor vestigial-like protein 2 - Homo sapiens (Human) - VGLL2 gene May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles. Taurus_UMD|evm.model.AC_000166.1.158 D2HNW6 RFX6_AILME 92.888 0.997845 1 RFX6 - DNA-binding protein RFX6 - Ailuropoda melanoleuca (Giant panda) - RFX6 gene Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription. Taurus_UMD|evm.model.AC_000166.1.159 E1BPQ3 GPC6A_BOVIN 73.968 0.992424 0.297297 GPRC6A - G-protein coupled receptor family C group 6 member A precursor - Bos taurus (Bovine) - GPRC6A gene Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (By similarity). Taurus_UMD|evm.model.AC_000166.1.161 A6QPI4 F162B_BOVIN 100.000 0.987805 1.00613 FAM162B - Protein FAM162B - Bos taurus (Bovine) - FAM162B gene Taurus_UMD|evm.model.AC_000166.1.162 O15131 IMA6_HUMAN 91.418 0.99006 0.938433 KPNA5 - Importin subunit alpha-6 - Homo sapiens (Human) - KPNA5 gene Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Taurus_UMD|evm.model.AC_000166.1.163 Q3SWY8 ZUP1_BOVIN 99.827 0.996552 1.00173 ZUP1 - Zinc finger-containing ubiquitin peptidase 1 - Bos taurus (Bovine) - ZUP1 gene Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress. Taurus_UMD|evm.model.AC_000166.1.164 Q5TD94 RSH4A_HUMAN 78.693 0.968188 1.00978 RSPH4A - Radial spoke head protein 4 homolog A - Homo sapiens (Human) - RSPH4A gene Component of the axonemal radial spoke head which plays an important role in ciliary motility (PubMed:19200523). Essential for triplet radial spokes (RS1, RS2 and RS3) head assembly in the motile cilia (By similarity). Taurus_UMD|evm.model.AC_000166.1.165 Q5E975 TM230_BOVIN 51.515 0.984962 1.10833 TMEM230 - Transmembrane protein 230 - Bos taurus (Bovine) - TMEM230 gene Involved in trafficking and recycling of synaptic vesicles. Taurus_UMD|evm.model.AC_000166.1.166 O46640 ST3A1_RABIT 70.508 0.909677 1.0299 SULT3A1 - Amine sulfotransferase - Oryctolagus cuniculus (Rabbit) - SULT3A1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the N-sulfonation of amines (PTHP, aniline, 4-chloroaniline, 2-naphthylamine). Taurus_UMD|evm.model.AC_000166.1.167 Q9H446 RWDD1_HUMAN 96.708 0.991803 1.00412 RWDD1 - RWD domain-containing protein 1 - Homo sapiens (Human) - RWDD1 gene Protects DRG2 from proteolytic degradation. Taurus_UMD|evm.model.AC_000166.1.168 Q5JW98 CAHM4_HUMAN 80.892 0.987382 1.00955 CALHM4 - Calcium homeostasis modulator protein 4 - Homo sapiens (Human) - CALHM4 gene Pore-forming subunit of a voltage-gated ion channel. Taurus_UMD|evm.model.AC_000166.1.169 Q5T215 TPC3L_HUMAN 94.059 0.862069 0.640884 TRAPPC3L - Trafficking protein particle complex subunit 3-like protein - Homo sapiens (Human) - TRAPPC3L gene May play a role in vesicular transport from endoplasmic reticulum to Golgi. Taurus_UMD|evm.model.AC_000166.1.170 Q5R3K3 CAHM6_HUMAN 76.489 0.993691 1.00635 CALHM6 - Calcium homeostasis modulator protein 6 - Homo sapiens (Human) - CALHM6 gene Pore-forming subunit of a voltage-gated ion channel. Taurus_UMD|evm.model.AC_000166.1.171 P0C2H4 DSE_BOVIN 99.896 0.943842 1.0595 DSE - Dermatan-sulfate epimerase precursor - Bos taurus (Bovine) - DSE gene Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate. Taurus_UMD|evm.model.AC_000166.1.172 Q0P5N2 TSYL1_BOVIN 100.000 0.995381 1.00231 TSPYL1 - Testis-specific Y-encoded-like protein 1 - Bos taurus (Bovine) - TSPYL1 gene chromatin, nucleus, chromatin binding, histone binding Taurus_UMD|evm.model.AC_000166.1.173 Q9UJ04 TSYL4_HUMAN 81.490 0.995181 1.00242 TSPYL4 - Testis-specific Y-encoded-like protein 4 - Homo sapiens (Human) - TSPYL4 gene chromatin, nucleus, chromatin binding, histone binding Taurus_UMD|evm.model.AC_000166.1.174 Q2TBU5 NT5D1_BOVIN 100.000 0.995585 1.00221 NT5DC1 - 5'-nucleotidase domain-containing protein 1 - Bos taurus (Bovine) - NT5DC1 gene 5'-nucleotidase activity Taurus_UMD|evm.model.AC_000166.1.175 Q922K9 FRK_MOUSE 88.716 0.996117 1.00586 Frk - Tyrosine-protein kinase FRK - Mus musculus (Mouse) - Frk gene Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity). Taurus_UMD|evm.model.AC_000166.1.176 Q96D71 REPS1_HUMAN 87.719 0.421053 0.167085 REPS1 - RalBP1-associated Eps domain-containing protein 1 - Homo sapiens (Human) - REPS1 gene May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. Taurus_UMD|evm.model.AC_000166.1.177 Q8BSL4 HS3S5_MOUSE 97.977 0.99422 1 Hs3st5 - Heparan sulfate glucosamine 3-O-sulfotransferase 5 - Mus musculus (Mouse) - Hs3st5 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2 (By similarity). Taurus_UMD|evm.model.AC_000166.1.178 Q92769 HDAC2_HUMAN 92.828 0.995662 0.944672 HDAC2 - Histone deacetylase 2 - Homo sapiens (Human) - HDAC2 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. Taurus_UMD|evm.model.AC_000166.1.180 P12624 MARCS_BOVIN 99.700 0.994012 1.003 MARCKS - Myristoylated alanine-rich C-kinase substrate - Bos taurus (Bovine) - MARCKS gene MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. Taurus_UMD|evm.model.AC_000166.1.182 Q0D252 F229B_BOVIN 100.000 0.975309 1.0125 FAM229B - Protein FAM229B - Bos taurus (Bovine) - FAM229B gene Taurus_UMD|evm.model.AC_000166.1.183 Q9UJT0 TBE_HUMAN 93.684 0.846429 1.17895 TUBE1 - Tubulin epsilon chain - Homo sapiens (Human) - TUBE1 gene cytoplasm, microtubule, pericentriolar material, GTP binding, structural constituent of cytoskeleton, centrosome cycle, microtubule cytoskeleton organization, mitotic cell cycle Taurus_UMD|evm.model.AC_000166.1.184 O95389 CCN6_HUMAN 83.616 0.994366 1.00282 CCN6 - Cellular communication network factor 6 precursor - Homo sapiens (Human) - CCN6 gene Plays a role in mitochondrial electron transport and mitochondrial respiration (PubMed:27252383). Through its regulation of the mitochondrial function may play a role in normal postnatal skeletal growth and cartilage homeostasis (PubMed:27252383, PubMed:10471507). Taurus_UMD|evm.model.AC_000166.1.187 A0JNB0 FYN_BOVIN 100.000 0.996283 1.00186 FYN - Tyrosine-protein kinase Fyn - Bos taurus (Bovine) - FYN gene Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Taurus_UMD|evm.model.AC_000166.1.188 O43734 CIKS_HUMAN 82.923 0.986038 0.998258 TRAF3IP2 - E3 ubiquitin ligase TRAF3IP2 - Homo sapiens (Human) - TRAF3IP2 gene E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828). Taurus_UMD|evm.model.AC_000166.1.190 O60673 REV3L_HUMAN 89.709 0.997711 0.976997 REV3L - DNA polymerase zeta catalytic subunit - Homo sapiens (Human) - REV3L gene Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. Taurus_UMD|evm.model.AC_000166.1.191 Q5TF39 MFS4B_HUMAN 84.854 0.901754 1.10039 MFSD4B - Sodium-dependent glucose transporter 1 - Homo sapiens (Human) - MFSD4B gene May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney. Taurus_UMD|evm.model.AC_000166.1.192 Q8TF71 MOT10_HUMAN 88.247 0.996124 1.00194 SLC16A10 - Monocarboxylate transporter 10 - Homo sapiens (Human) - SLC16A10 gene Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity). Taurus_UMD|evm.model.AC_000166.1.193 Q2YDN6 RPF2_BOVIN 99.673 0.993485 1.00327 RPF2 - Ribosome production factor 2 homolog - Bos taurus (Bovine) - RPF2 gene Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. Taurus_UMD|evm.model.AC_000166.1.194 Q969F1 TF3C6_HUMAN 85.870 0.75 1.14554 GTF3C6 - General transcription factor 3C polypeptide 6 - Homo sapiens (Human) - GTF3C6 gene Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. Taurus_UMD|evm.model.AC_000166.1.195 P50243 DCAM_BOVIN 100.000 0.99403 1.00299 AMD1 - S-adenosylmethionine decarboxylase proenzyme precursor - Bos taurus (Bovine) - AMD1 gene Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. Taurus_UMD|evm.model.AC_000166.1.196 Q9BWU1 CDK19_HUMAN 98.207 0.996008 0.998008 CDK19 - Cyclin-dependent kinase 19 - Homo sapiens (Human) - CDK19 gene cytosol, mediator complex, nucleus, cyclin-dependent protein serine/threonine kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity, protein phosphorylation Taurus_UMD|evm.model.AC_000166.1.197 Q17QN9 S22AG_BOVIN 100.000 0.99651 1.00175 SLC22A16 - Solute carrier family 22 member 16 - Bos taurus (Bovine) - SLC22A16 gene High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent (By similarity). Taurus_UMD|evm.model.AC_000166.1.198 P31228 OXDD_BOVIN 99.413 0.994152 1.00293 DDO - D-aspartate oxidase - Bos taurus (Bovine) - DDO gene Taurus_UMD|evm.model.AC_000166.1.199 Q5JXM2 MET24_HUMAN 85.902 0.932515 0.89071 METTL24 - Methyltransferase-like protein 24 precursor - Homo sapiens (Human) - METTL24 gene Taurus_UMD|evm.model.AC_000166.1.200 O60508 PRP17_HUMAN 98.446 0.996552 1.00173 CDC40 - Pre-mRNA-processing factor 17 - Homo sapiens (Human) - CDC40 gene Required for pre-mRNA splicing as component of the activated spliceosome. Taurus_UMD|evm.model.AC_000166.1.201 Q0IIJ3 WASF1_BOVIN 100.000 0.996429 1.00179 WASF1 - Wiskott-Aldrich syndrome protein family member 1 - Bos taurus (Bovine) - WASF1 gene Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (By similarity). Taurus_UMD|evm.model.AC_000166.1.202 P46095 GPR6_HUMAN 92.603 0.994536 1.01105 GPR6 - G-protein coupled receptor 6 - Homo sapiens (Human) - GPR6 gene Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Taurus_UMD|evm.model.AC_000166.1.203 Q92562 FIG4_HUMAN 95.039 0.997755 0.982359 FIG4 - Polyphosphoinositide phosphatase - Homo sapiens (Human) - FIG4 gene The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. Taurus_UMD|evm.model.AC_000166.1.204 O43167 ZBT24_HUMAN 93.848 0.261637 3.82209 ZBTB24 - Zinc finger and BTB domain-containing protein 24 - Homo sapiens (Human) - ZBTB24 gene May be involved in BMP2-induced transcription. Taurus_UMD|evm.model.AC_000166.1.205 F1MH07 MICA1_BOVIN 100.000 0.938053 1.05607 MICAL1 - [F-actin]-monooxygenase MICAL1 - Bos taurus (Bovine) - MICAL1 gene Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking. Taurus_UMD|evm.model.AC_000166.1.206 O60906 NSMA_HUMAN 84.870 0.995283 1.00236 SMPD2 - Sphingomyelin phosphodiesterase 2 - Homo sapiens (Human) - SMPD2 gene Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). Taurus_UMD|evm.model.AC_000166.1.207 Q1RMP7 PPIL6_BOVIN 100.000 0.993506 1.00326 PPIL6 - Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 - Bos taurus (Bovine) - PPIL6 gene Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. Taurus_UMD|evm.model.AC_000166.1.208 Q2YDH0 MUC24_BOVIN 100.000 0.98995 1.00505 CD164 - Sialomucin core protein 24 precursor - Bos taurus (Bovine) - CD164 gene Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity). Taurus_UMD|evm.model.AC_000166.1.209 Q0VG85 CC162_MOUSE 73.823 0.40514 2.34649 Ccdc162 - Coiled-coil domain-containing protein 162 - Mus musculus (Mouse) - Ccdc162 gene Taurus_UMD|evm.model.AC_000166.1.210 Q8IYX8 CE57L_HUMAN 80.294 0.995807 1.03696 CEP57L1 - Centrosomal protein CEP57L1 - Homo sapiens (Human) - CEP57L1 gene Centrosomal protein which may be required for microtubule attachment to centrosomes. Taurus_UMD|evm.model.AC_000166.1.211 P58006 SESN1_MOUSE 98.257 0.82971 1.12195 Sesn1 - Sestrin-1 - Mus musculus (Mouse) - Sesn1 gene Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25259925). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed (By similarity). Taurus_UMD|evm.model.AC_000166.1.212 P0C6R2 ARMC2_BOVIN 87.659 0.997537 0.938728 ARMC2 - Armadillo repeat-containing protein 2 - Bos taurus (Bovine) - ARMC2 gene Required for sperm flagellum axoneme organization and function. Involved in axonemal central pair complex assembly and/or stability. Taurus_UMD|evm.model.AC_000166.1.213 O43524 FOXO3_HUMAN 95.542 0.997028 1 FOXO3 - Forkhead box protein O3 - Homo sapiens (Human) - FOXO3 gene Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Taurus_UMD|evm.model.AC_000166.1.215 Q8WV93 AFG1L_HUMAN 92.931 0.995842 1 AFG1L - AFG1-like ATPase - Homo sapiens (Human) - AFG1L gene Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain (PubMed:26759378, PubMed:27323408). Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress (PubMed:27323408). Taurus_UMD|evm.model.AC_000166.1.216 P79103 RS4_BOVIN 98.859 0.992395 1 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000166.1.217 Q5U211 SNX3_RAT 100.000 0.98773 1.00617 Snx3 - Sorting nexin-3 - Rattus norvegicus (Rat) - Snx3 gene Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor Tfrc presuambly by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex. Involved in regulation of neurite outgrowth in primary neurons. Taurus_UMD|evm.model.AC_000166.1.218 Q9Y466 NR2E1_HUMAN 98.168 0.84292 1.17403 NR2E1 - Nuclear receptor subfamily 2 group E member 1 - Homo sapiens (Human) - NR2E1 gene Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells. Taurus_UMD|evm.model.AC_000166.1.219 Q5E9F5 TAGL2_BOVIN 88.945 0.99 1.00503 TAGLN2 - Transgelin-2 - Bos taurus (Bovine) - TAGLN2 gene Taurus_UMD|evm.model.AC_000166.1.220 Q86WC4 OSTM1_HUMAN 90.301 0.886567 1.00299 OSTM1 - Osteopetrosis-associated transmembrane protein 1 precursor - Homo sapiens (Human) - OSTM1 gene Required for osteoclast and melanocyte maturation and function. Taurus_UMD|evm.model.AC_000166.1.221 Q9UGP8 SEC63_HUMAN 98.421 0.997372 1.00132 SEC63 - Translocation protein SEC63 homolog - Homo sapiens (Human) - SEC63 gene Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). Taurus_UMD|evm.model.AC_000166.1.222 Q8N228 SCML4_HUMAN 96.454 0.426829 0.792271 SCML4 - Sex comb on midleg-like protein 4 - Homo sapiens (Human) - SCML4 gene Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). Taurus_UMD|evm.model.AC_000166.1.223 A7XYH9 SOBP_BOVIN 96.216 0.997622 0.96445 SOBP - Sine oculis-binding protein homolog - Bos taurus (Bovine) - SOBP gene Implicated in development of the cochlea. Taurus_UMD|evm.model.AC_000166.1.224 Q86YH6 DLP1_HUMAN 88.793 0.982609 0.576441 PDSS2 - All trans-polyprenyl-diphosphate synthase PDSS2 - Homo sapiens (Human) - PDSS2 gene Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone (PubMed:16262699). Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9) and ubiquinone-10 (Q10) respectively (PubMed:16262699). The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry (PubMed:16262699). May play a role during cerebellar development (By similarity). May regulate mitochondrial respiratory chain function (By similarity). Taurus_UMD|evm.model.AC_000166.1.225 Q5T5X7 BEND3_HUMAN 93.727 0.952819 1.04952 BEND3 - BEN domain-containing protein 3 - Homo sapiens (Human) - BEND3 gene Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). Taurus_UMD|evm.model.AC_000166.1.226 Q9P0P8 MRES1_HUMAN 83.544 0.635246 1.01667 MTRES1 - Mitochondrial transcription rescue factor 1 precursor - Homo sapiens (Human) - MTRES1 gene Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability (PubMed:31226201). Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation (PubMed:33243891, PubMed:31396629). As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue (PubMed:33243891). Taurus_UMD|evm.model.AC_000166.1.227 P25063 CD24_HUMAN 75.949 0.961538 0.975 CD24 - Signal transducer CD24 precursor - Homo sapiens (Human) - CD24 gene May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity). Taurus_UMD|evm.model.AC_000166.1.228 Q07761 RL23A_TOBAC 74.725 0.717742 0.805195 RPL23A - 60S ribosomal protein L23a - Nicotiana tabacum (Common tobacco) - RPL23A gene This protein binds to a specific region on the 26S rRNA. Taurus_UMD|evm.model.AC_000166.1.229 Q29RP9 GATA_BOVIN 99.810 0.996205 1.0019 QRSL1 - Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial - Bos taurus (Bovine) - QRSL1 gene Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Taurus_UMD|evm.model.AC_000166.1.230 Q0VC50 RT4I1_BOVIN 100.000 0.994962 1.00253 RTN4IP1 - Reticulon-4-interacting protein 1, mitochondrial precursor - Bos taurus (Bovine) - RTN4IP1 gene Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury. Taurus_UMD|evm.model.AC_000166.1.231 Q9Y4K1 CRBG1_HUMAN 79.585 0.807456 1.22983 CRYBG1 - Beta/gamma crystallin domain-containing protein 1 - Homo sapiens (Human) - CRYBG1 gene May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. Taurus_UMD|evm.model.AC_000166.1.232 Q3MQ24 ATG5_BOVIN 100.000 0.918605 0.625455 ATG5 - Autophagy protein 5 - Bos taurus (Bovine) - ATG5 gene Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. Taurus_UMD|evm.model.AC_000166.1.234 Q3MQ24 ATG5_BOVIN 98.319 0.951613 0.450909 ATG5 - Autophagy protein 5 - Bos taurus (Bovine) - ATG5 gene Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. Taurus_UMD|evm.model.AC_000166.1.235 O75626 PRDM1_HUMAN 87.575 0.997587 1.00485 PRDM1 - PR domain zinc finger protein 1 - Homo sapiens (Human) - PRDM1 gene Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity). Taurus_UMD|evm.model.AC_000166.1.236 P21533 RL6_RAT 44.037 0.864407 0.395973 Rpl6 - 60S ribosomal protein L6 - Rattus norvegicus (Rat) - Rpl6 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000166.1.237 Q6Q311 RS25_SHEEP 93.827 0.879121 0.728 RPS25 - 40S ribosomal protein S25 - Ovis aries (Sheep) - RPS25 gene Taurus_UMD|evm.model.AC_000166.1.238 Q9XTA2 PPCE_BOVIN 98.994 0.94046 1.04085 PREP - Prolyl endopeptidase - Bos taurus (Bovine) - PREP gene Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Taurus_UMD|evm.model.AC_000166.1.239 Q8VH49 HIG1A_RAT 83.871 0.978723 1.01075 Higd1a - HIG1 domain family member 1A, mitochondrial - Rattus norvegicus (Rat) - Higd1a gene Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). Taurus_UMD|evm.model.AC_000166.1.240 Q9HBV1 POPD3_HUMAN 92.440 0.993151 1.00344 POPDC3 - Popeye domain-containing protein 3 - Homo sapiens (Human) - POPDC3 gene May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding. May play a role in the regulation of KCNK2/TREK-1-mediated current amplitude (PubMed:31610034). Taurus_UMD|evm.model.AC_000166.1.241 B8Q0B2 POPD1_PIG 91.197 0.700495 1.12222 BVES - Blood vessel epicardial substance - Sus scrofa (Pig) - BVES gene Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Important for skeletal muscle and heart development. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury (By similarity). Taurus_UMD|evm.model.AC_000166.1.242 Q6ZN17 LN28B_HUMAN 90.625 0.59434 0.424 LIN28B - Protein lin-28 homolog B - Homo sapiens (Human) - LIN28B gene Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. Taurus_UMD|evm.model.AC_000166.1.243 F1N6G5 HACE1_BOVIN 100.000 0.997802 1.0011 HACE1 - E3 ubiquitin-protein ligase HACE1 - Bos taurus (Bovine) - HACE1 gene E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. Taurus_UMD|evm.model.AC_000166.1.246 P62630 EF1A1_RAT 95.312 0.617647 0.220779 Eef1a1 - Elongation factor 1-alpha 1 - Rattus norvegicus (Rat) - Eef1a1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000166.1.247 P68105 EF1A1_RABIT 94.805 0.993528 0.668831 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000166.1.250 A0A0B4J1U6 TVB9_HUMAN 66.316 0.717557 1.14912 TRBV9 - T cell receptor beta variable 9 precursor - Homo sapiens (Human) - TRBV9 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000166.1.251 Q8NCR0 B3GL2_HUMAN 88.152 0.985915 0.426 B3GALNT2 - UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 - Homo sapiens (Human) - B3GALNT2 gene Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Taurus_UMD|evm.model.AC_000166.1.253 E1BNG3 ASCC3_BOVIN 100.000 0.999092 1.00045 ascc3 - Activating signal cointegrator 1 complex subunit 3 - Bos taurus (Bovine) - ascc3 gene 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Taurus_UMD|evm.model.AC_000166.1.254 P81133 SIM1_HUMAN 100.000 0.393939 0.818538 SIM1 - Single-minded homolog 1 - Homo sapiens (Human) - SIM1 gene Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. Taurus_UMD|evm.model.AC_000166.1.255 P62309 RUXG_MOUSE 90.789 0.973684 1 Snrpg - Small nuclear ribonucleoprotein G - Mus musculus (Mouse) - Snrpg gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. Taurus_UMD|evm.model.AC_000166.1.256 P62944 AP2B1_RAT 82.043 0.855544 1.04909 Ap2b1 - AP-2 complex subunit beta - Rattus norvegicus (Rat) - Ap2b1 gene Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly (By similarity). Taurus_UMD|evm.model.AC_000166.1.257 Q8SQ54 MCHR2_MACFA 84.545 0.52657 0.608824 MCHR2 - Melanin-concentrating hormone receptor 2 - Macaca fascicularis (Crab-eating macaque) - MCHR2 gene Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis. Taurus_UMD|evm.model.AC_000166.1.259 Q9H4Q3 PRD13_HUMAN 90.268 0.997175 1.00141 PRDM13 - PR domain zinc finger protein 13 - Homo sapiens (Human) - PRDM13 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000166.1.260 Q3ZCK5 CCNC_BOVIN 100.000 0.992958 1.00353 CCNC - Cyclin-C - Bos taurus (Bovine) - CCNC gene Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity). Taurus_UMD|evm.model.AC_000166.1.261 H0UI37 TSTD3_HUMAN 77.011 0.5375 1.64948 TSTD3 - Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3 - Homo sapiens (Human) - TSTD3 gene Taurus_UMD|evm.model.AC_000166.1.262 Q70EL2 UBP45_HUMAN 81.563 0.997555 1.00491 USP45 - Ubiquitin carboxyl-terminal hydrolase 45 - Homo sapiens (Human) - USP45 gene Catalyzes the deubiquitination of SPDL1 (PubMed:30258100). Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (PubMed:25538220). May be involved in the maintenance of photoreceptor function (PubMed:30573563). May play a role in normal retinal development (By similarity). Plays a role in cell migration (PubMed:30258100). Taurus_UMD|evm.model.AC_000166.1.265 Q8TF01 PNISR_HUMAN 95.901 0.986284 0.996273 PNISR - Arginine/serine-rich protein PNISR - Homo sapiens (Human) - PNISR gene cytosol, nuclear speck, nucleoplasm, plasma membrane, presynaptic active zone, RNA binding Taurus_UMD|evm.model.AC_000166.1.266 Q3T131 COQ3_BOVIN 99.459 0.994609 1.0027 COQ3 - Ubiquinone biosynthesis O-methyltransferase, mitochondrial precursor - Bos taurus (Bovine) - COQ3 gene O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. Taurus_UMD|evm.model.AC_000166.1.267 F7E235 FAXC_XENTR 80.531 0.436047 1.27094 faxc - Failed axon connections homolog - Xenopus tropicalis (Western clawed frog) - faxc gene May play a role in axonal development. Taurus_UMD|evm.model.AC_000166.1.268 Q0VD31 FBXL4_BOVIN 100.000 0.979866 0.719807 FBXL4 - F-box/LRR-repeat protein 4 - Bos taurus (Bovine) - FBXL4 gene mitochondrial intermembrane space Taurus_UMD|evm.model.AC_000166.1.269 Q0VD31 FBXL4_BOVIN 94.286 0.792308 0.20934 FBXL4 - F-box/LRR-repeat protein 4 - Bos taurus (Bovine) - FBXL4 gene mitochondrial intermembrane space Taurus_UMD|evm.model.AC_000166.1.270 P31360 PO3F2_MOUSE 100.000 0.965517 0.45618 Pou3f2 - POU domain, class 3, transcription factor 2 - Mus musculus (Mouse) - Pou3f2 gene Transcription factor that plays a key role in neuronal differentiation (PubMed:24243019). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (PubMed:18505825, PubMed:18403418). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (PubMed:24243019). Taurus_UMD|evm.model.AC_000166.1.271 P20265 PO3F2_HUMAN 98.333 0.719512 0.185102 POU3F2 - POU domain, class 3, transcription factor 2 - Homo sapiens (Human) - POU3F2 gene Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity). Taurus_UMD|evm.model.AC_000166.1.272 P24049 RL17_RAT 93.056 0.865854 0.445652 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000166.1.275 E1BGH8 MMS22_BOVIN 99.851 0.625584 0.860932 MMS22L - Protein MMS22-like - Bos taurus (Bovine) - MMS22L gene Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA (By similarity). Taurus_UMD|evm.model.AC_000166.1.276 Q96NJ5 KLH32_HUMAN 98.226 0.996779 1.00161 KLHL32 - Kelch-like protein 32 - Homo sapiens (Human) - KLHL32 gene Taurus_UMD|evm.model.AC_000166.1.277 A4FUH5 NDUF4_BOVIN 100.000 0.988636 1.00571 NDUFAF4 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 - Bos taurus (Bovine) - NDUFAF4 gene Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion (By similarity). Taurus_UMD|evm.model.AC_000166.1.278 Q9BZJ6 GPR63_HUMAN 93.795 0.995238 1.00239 GPR63 - Probable G-protein coupled receptor 63 - Homo sapiens (Human) - GPR63 gene Orphan receptor. May play a role in brain function. Taurus_UMD|evm.model.AC_000166.1.279 Q2YDK0 FHL5_BOVIN 100.000 0.992982 1.00352 FHL5 - Four and a half LIM domains protein 5 - Bos taurus (Bovine) - FHL5 gene May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner (By similarity). Taurus_UMD|evm.model.AC_000166.1.280 A1A4I9 UFL1_BOVIN 100.000 0.997478 1.00126 UFL1 - E3 UFM1-protein ligase 1 - Bos taurus (Bovine) - UFL1 gene E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (By similarity). In response to endoplasmic reticulum stress, recruited to the endoplasmic reticulum membrane by DDRGK1, and mediates ufmylation of proteins such as RPN1 and RPL26/uL24, thereby promoting reticulophagy of endoplasmic reticulum sheets (By similarity). Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) via ERN1/IRE1-alpha (By similarity). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response (PubMed:30881595). Regulates inflammation in response to endoplasmic reticulum stress by promoting reticulophagy, leading to inhibit the activity of the NF-kappa-B transcription factor (PubMed:31721015, PubMed:31078114, PubMed:30881595, PubMed:32050508). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is a collateral effect or is required for ufmylation (By similarity). Catalyzes ufmylation of various subunits of the ribosomal complex or associated components, such as RPS3/uS3, RPS20/uS10, RPL10/uL16, RPL26/uL24 and EIF6 (By similarity). Anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (By similarity). Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 (By similarity). Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription (By similarity). Required for hematopoietic stem cell function and hematopoiesis. Required for cardiac homeostasis (By similarity). Taurus_UMD|evm.model.AC_000166.1.281 Q8HZR2 FUT9_BOVIN 99.721 0.994444 1.00279 FUT9 - 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 - Bos taurus (Bovine) - FUT9 gene Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal lactosamine unit of a glycoprotein or a glycolipid-linked polylactosamine chains through an alpha-1,3 glycosidic linkage and participates in particular to the Lewis x (Lex)/CD15 epitope biosynthesis in neurons which allows cell differentiation, cell adhesion, and initiation of neurite outgrowth. Also fucosylates di-, tri- and tetraantennary N-glycans linked to glycoproteins and the inner lactosamine unit of the alpha2,3-sialylated polylactosamine resulting in sLex (CD15s) epitope synthesis. Furthermore, it is capable to synthesizes Lewis a (Lea), although to a lesser extent than Lex and Lewis y (Ley) and to confer SELE-dependent, but not SELL- and SELP-selectin-dependent, cell rolling and adhesion by enhancing Lex and sLex synthesis. Taurus_UMD|evm.model.AC_000166.1.282 Q95N02 CLTR1_PIG 91.892 0.63913 0.676471 CYSLTR1 - Cysteinyl leukotriene receptor 1 - Sus scrofa (Pig) - CYSLTR1 gene Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). Taurus_UMD|evm.model.AC_000166.1.283 Q5RD93 MANEA_PONAB 84.061 0.811388 1.21645 MANEA - Glycoprotein endo-alpha-1,2-mannosidase - Pongo abelii (Sumatran orangutan) - MANEA gene Taurus_UMD|evm.model.AC_000166.1.286 Q5R573 RBL2A_PONAB 59.276 0.976048 0.729258 RABL2A - Rab-like protein 2A - Pongo abelii (Sumatran orangutan) - RABL2A gene Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail. Taurus_UMD|evm.model.AC_000166.1.287 Q5D7J1 TRIM5_PANTR 55.061 0.929961 0.521298 TRIM5 - Tripartite motif-containing protein 5 - Pan troglodytes (Chimpanzee) - TRIM5 gene Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2. Taurus_UMD|evm.model.AC_000166.1.288 P16423 POLR_DROME 31.053 0.651724 0.274361 pol - Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM - Drosophila melanogaster (Fruit fly) - pol gene Taurus_UMD|evm.model.AC_000166.1.289 Q15375 EPHA7_HUMAN 97.996 0.997986 0.99499 EPHA7 - Ephrin type-A receptor 7 precursor - Homo sapiens (Human) - EPHA7 gene Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. Taurus_UMD|evm.model.AC_000166.1.290 Q58D08 P5CR3_BOVIN 73.077 0.344595 0.480519 PYCR3 - Pyrroline-5-carboxylate reductase 3 - Bos taurus (Bovine) - PYCR3 gene Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. Taurus_UMD|evm.model.AC_000166.1.292 Q3T0Q8 UT14A_BOVIN 76.841 0.96904 0.838961 UTP14A - U3 small nucleolar RNA-associated protein 14 homolog A - Bos taurus (Bovine) - UTP14A gene May be required for ribosome biogenesis. Taurus_UMD|evm.model.AC_000166.1.293 O43318 M3K7_HUMAN 99.010 0.996705 1.00165 MAP3K7 - Mitogen-activated protein kinase kinase kinase 7 - Homo sapiens (Human) - MAP3K7 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity. Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Taurus_UMD|evm.model.AC_000166.1.295 Q8NH57 O52P1_HUMAN 58.986 0.866397 0.76947 OR52P1P - Putative olfactory receptor 52P1 - Homo sapiens (Human) - OR52P1P gene Odorant receptor. Taurus_UMD|evm.model.AC_000166.1.296 Q9BYV9 BACH2_HUMAN 93.713 0.966705 1.03567 BACH2 - Transcription regulator protein BACH2 - Homo sapiens (Human) - BACH2 gene Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). Taurus_UMD|evm.model.AC_000166.1.297 Q969M2 CXA10_HUMAN 81.250 0.980932 0.869245 GJA10 - Gap junction alpha-10 protein - Homo sapiens (Human) - GJA10 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning (By similarity). Taurus_UMD|evm.model.AC_000166.1.298 Q9UKL3 C8AP2_HUMAN 76.873 0.998987 0.995964 CASP8AP2 - CASP8-associated protein 2 - Homo sapiens (Human) - CASP8AP2 gene Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. Taurus_UMD|evm.model.AC_000166.1.299 Q9NU22 MDN1_HUMAN 87.458 0.999464 0.999464 MDN1 - Midasin - Homo sapiens (Human) - MDN1 gene Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity). Taurus_UMD|evm.model.AC_000166.1.300 Q32LM5 LYRM2_BOVIN 100.000 0.977528 1.01136 LYRM2 - LYR motif-containing protein 2 - Bos taurus (Bovine) - LYRM2 gene Taurus_UMD|evm.model.AC_000166.1.301 Q9Y2G4 ANKR6_HUMAN 91.495 0.99726 1.00413 ANKRD6 - Ankyrin repeat domain-containing protein 6 - Homo sapiens (Human) - ANKRD6 gene Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals. Taurus_UMD|evm.model.AC_000166.1.302 Q32L92 CNN3_BOVIN 77.049 0.632184 0.264438 CNN3 - Calponin-3 - Bos taurus (Bovine) - CNN3 gene Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). Taurus_UMD|evm.model.AC_000166.1.303 Q9NQL2 RRAGD_HUMAN 97.500 0.994975 0.995 RRAGD - Ras-related GTP-binding protein D - Homo sapiens (Human) - RRAGD gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279). Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form (PubMed:24095279). In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279). This is a crucial step in the activation of the TOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279). Taurus_UMD|evm.model.AC_000166.1.304 Q9Y385 UB2J1_HUMAN 95.597 0.99373 1.00314 UBE2J1 - Ubiquitin-conjugating enzyme E2 J1 - Homo sapiens (Human) - UBE2J1 gene Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Taurus_UMD|evm.model.AC_000166.1.305 P50572 GBRR1_RAT 86.168 0.904762 1.00625 Gabrr1 - Gamma-aminobutyric acid receptor subunit rho-1 precursor - Rattus norvegicus (Rat) - Gabrr1 gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission. Taurus_UMD|evm.model.AC_000166.1.306 Q8IYS1 P20D2_HUMAN 87.703 0.995338 0.983945 PM20D2 - Peptidase M20 domain-containing protein 2 - Homo sapiens (Human) - PM20D2 gene nucleoplasm, dipeptidase activity, identical protein binding, proteolysis, regulation of cellular protein metabolic process Taurus_UMD|evm.model.AC_000166.1.307 Q8WXF0 SRS12_HUMAN 97.590 0.988024 0.639847 SRSF12 - Serine/arginine-rich splicing factor 12 - Homo sapiens (Human) - SRSF12 gene Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation. Taurus_UMD|evm.model.AC_000166.1.308 Q12796 PNRC1_HUMAN 87.234 0.993939 1.00917 PNRC1 - Proline-rich nuclear receptor coactivator 1 - Homo sapiens (Human) - PNRC1 gene Nuclear receptor coactivator. May play a role in signal transduction. Taurus_UMD|evm.model.AC_000166.1.310 O60942 MCE1_HUMAN 98.207 0.998008 0.840871 RNGTT - mRNA-capping enzyme - Homo sapiens (Human) - RNGTT gene Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. Taurus_UMD|evm.model.AC_000166.1.311 Q5IS73 CNR1_PANTR 97.246 0.995772 1.00212 CNR1 - Cannabinoid receptor 1 - Pan troglodytes (Chimpanzee) - CNR1 gene G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (By similarity). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia. In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes. In the liver, activation by cannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake. Peripherally modulates energy metabolism. In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism. In response to cannabinoid anandamide, elicits a proinflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion (By similarity). Taurus_UMD|evm.model.AC_000166.1.312 Q2YDG7 SACA1_BOVIN 92.977 0.993333 1.07527 SPACA1 - Sperm acrosome membrane-associated protein 1 precursor - Bos taurus (Bovine) - SPACA1 gene Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility. Taurus_UMD|evm.model.AC_000166.1.313 A8YXY8 AKIR2_BOVIN 76.355 0.987179 0.768473 AKIRIN2 - Akirin-2 - Bos taurus (Bovine) - AKIRIN2 gene Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). Taurus_UMD|evm.model.AC_000166.1.314 Q32PJ3 ORC3_BOVIN 99.860 0.997195 1.0014 ORC3 - Origin recognition complex subunit 3 - Bos taurus (Bovine) - ORC3 gene Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. Taurus_UMD|evm.model.AC_000166.1.315 Q0P5H7 SYRM_BOVIN 100.000 0.996546 1.00173 RARS2 - Probable arginine--tRNA ligase, mitochondrial precursor - Bos taurus (Bovine) - RARS2 gene mitochondrion, arginine-tRNA ligase activity, arginyl-tRNA aminoacylation, mitochondrial translation Taurus_UMD|evm.model.AC_000166.1.316 P78382 S35A1_HUMAN 95.252 0.994083 1.00297 SLC35A1 - CMP-sialic acid transporter - Homo sapiens (Human) - SLC35A1 gene Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function (PubMed:15576474). Efficient CMP-sialic acid uptake depends on the presence of free CMP inside the vesicles, suggesting the proteins functions as an antiporter. Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (By similarity). Taurus_UMD|evm.model.AC_000166.1.317 Q29RL1 CF206_BOVIN 100.000 0.99679 1.00161 CFAP206 - Cilia- and flagella-associated protein 206 - Bos taurus (Bovine) - CFAP206 gene Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (By similarity). Required for the establishment of radial spokes in sperm flagella (By similarity). Taurus_UMD|evm.model.AC_000166.1.318 A2VDV9 SMIM8_BOVIN 98.795 0.231638 3.64948 SMIM8 - Small integral membrane protein 8 - Bos taurus (Bovine) - SMIM8 gene Taurus_UMD|evm.model.AC_000166.1.320 Q6PEY0 CXB7_HUMAN 91.111 0.716578 0.838565 GJB7 - Gap junction beta-7 protein - Homo sapiens (Human) - GJB7 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Taurus_UMD|evm.model.AC_000166.1.321 O60281 ZN292_HUMAN 91.016 0.999265 0.998898 ZNF292 - Zinc finger protein 292 - Homo sapiens (Human) - ZNF292 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000166.1.322 A8D8X1 RL10_SHEEP 85.890 0.987805 0.766355 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000166.1.323 P01217 GLHA_BOVIN 100.000 0.983471 1.00833 CGA - Glycoprotein hormones alpha chain precursor - Bos taurus (Bovine) - CGA gene Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. Taurus_UMD|evm.model.AC_000166.1.324 Q6VB83 5HT1E_CAVPO 95.890 0.994536 1.00274 5HT1E - 5-hydroxytryptamine receptor 1E - Cavia porcellus (Guinea pig) - 5HT1E gene G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Taurus_UMD|evm.model.AC_000166.1.326 Q9Y6A5 TACC3_HUMAN 84.615 0.506667 0.0894988 TACC3 - Transforming acidic coiled-coil-containing protein 3 - Homo sapiens (Human) - TACC3 gene Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). Taurus_UMD|evm.model.AC_000166.1.329 O60506 HNRPQ_HUMAN 100.000 0.973357 0.903692 SYNCRIP - Heterogeneous nuclear ribonucleoprotein Q - Homo sapiens (Human) - SYNCRIP gene Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. Taurus_UMD|evm.model.AC_000166.1.330 Q5R903 SNX14_PONAB 92.953 0.941176 1.02685 SNX14 - Sorting nexin-14 - Pongo abelii (Sumatran orangutan) - SNX14 gene Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking. Taurus_UMD|evm.model.AC_000166.1.331 Q05927 5NTD_BOVIN 98.769 0.915254 0.616725 NT5E - 5'-nucleotidase precursor - Bos taurus (Bovine) - NT5E gene Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Taurus_UMD|evm.model.AC_000166.1.332 Q05927 5NTD_BOVIN 99.602 0.862069 0.505226 NT5E - 5'-nucleotidase precursor - Bos taurus (Bovine) - NT5E gene Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Taurus_UMD|evm.model.AC_000166.1.333 Q76LV1 HS90B_BOVIN 61.285 0.967742 0.685083 HSP90AB1 - Heat shock protein HSP 90-beta - Bos taurus (Bovine) - HSP90AB1 gene Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10. Taurus_UMD|evm.model.AC_000166.1.334 Q5R893 H2B1_PONAB 89.552 0.970588 0.539683 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000166.1.335 O95935 TBX18_HUMAN 95.752 0.996737 1.00988 TBX18 - T-box transcription factor TBX18 - Homo sapiens (Human) - TBX18 gene Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area. Taurus_UMD|evm.model.AC_000166.1.336 O43812 DUX1_HUMAN 70.769 0.201893 1.86471 DUX1 - Double homeobox protein 1 - Homo sapiens (Human) - DUX1 gene Probable transcription activator. Binds the P5 DNA element sequence 5'-GATCTGAGTCTAATTGAGAATTACTGTAC-3'. Taurus_UMD|evm.model.AC_000166.1.337 Q5TB80 CE162_HUMAN 80.567 0.998534 0.972202 CEP162 - Centrosomal protein of 162 kDa - Homo sapiens (Human) - CEP162 gene Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. Taurus_UMD|evm.model.AC_000166.1.338 Q96G30 MRAP2_HUMAN 91.220 0.990291 1.00488 MRAP2 - Melanocortin-2 receptor accessory protein 2 - Homo sapiens (Human) - MRAP2 gene Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo. Taurus_UMD|evm.model.AC_000166.1.339 Q15041 AR6P1_HUMAN 94.118 0.118203 2.08374 ARL6IP1 - ADP-ribosylation factor-like protein 6-interacting protein 1 - Homo sapiens (Human) - ARL6IP1 gene Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules (PubMed:24262037). Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself (PubMed:12754298). May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (PubMed:10995579). Taurus_UMD|evm.model.AC_000166.1.340 Q32LH7 NB5R4_BOVIN 100.000 0.944444 0.276923 CYB5R4 - Cytochrome b5 reductase 4 - Bos taurus (Bovine) - CYB5R4 gene NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS) (By similarity). Taurus_UMD|evm.model.AC_000166.1.341 Q5TAB7 RIPP2_HUMAN 78.095 0.634146 1.28125 RIPPLY2 - Protein ripply2 - Homo sapiens (Human) - RIPPLY2 gene Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites (By similarity). Taurus_UMD|evm.model.AC_000166.1.342 Q5RCP8 H2B2E_PONAB 89.189 0.763889 1.14286 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000166.1.343 Q6P5S2 LEG1H_HUMAN 30.000 0.839888 1.07879 LEG1 - Protein LEG1 homolog precursor - Homo sapiens (Human) - LEG1 gene May be involved in early liver development. Taurus_UMD|evm.model.AC_000166.1.344 A5D789 THMS1_BOVIN 99.641 0.739362 1.17317 THEMIS - Protein THEMIS - Bos taurus (Bovine) - THEMIS gene Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. Taurus_UMD|evm.model.AC_000166.1.345 Q15262 PTPRK_HUMAN 99.374 0.997222 1.00069 PTPRK - Receptor-type tyrosine-protein phosphatase kappa precursor - Homo sapiens (Human) - PTPRK gene Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. Taurus_UMD|evm.model.AC_000166.1.346 O60361 NDK8_HUMAN 54.545 0.734694 1.07299 NME2P1 - Putative nucleoside diphosphate kinase - Homo sapiens (Human) - NME2P1 gene Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Taurus_UMD|evm.model.AC_000166.1.347 P24043 LAMA2_HUMAN 91.095 0.937899 0.55189 LAMA2 - Laminin subunit alpha-2 precursor - Homo sapiens (Human) - LAMA2 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Taurus_UMD|evm.model.AC_000166.1.348 Q8N392 RHG18_HUMAN 86.486 0.921093 0.993967 ARHGAP18 - Rho GTPase-activating protein 18 - Homo sapiens (Human) - ARHGAP18 gene Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). Taurus_UMD|evm.model.AC_000166.1.349 Q4PLJ0 NEDD8_RABIT 81.481 0.930233 1.06173 NEDD8 - NEDD8 precursor - Oryctolagus cuniculus (Rabbit) - NEDD8 gene Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). Taurus_UMD|evm.model.AC_000166.1.350 Q8BLB7 LMBL3_MOUSE 98.230 0.143406 0.884485 L3mbtl3 - Lethal(3)malignant brain tumor-like protein 3 - Mus musculus (Mouse) - L3mbtl3 gene Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Required for normal maturation of myeloid progenitor cells. Taurus_UMD|evm.model.AC_000166.1.351 Q8N6K7 SAMD3_HUMAN 87.308 0.996086 0.982692 SAMD3 - Sterile alpha motif domain-containing protein 3 - Homo sapiens (Human) - SAMD3 gene Taurus_UMD|evm.model.AC_000166.1.352 Q86VY9 T200A_HUMAN 93.279 0.995935 1.00204 TMEM200A - Transmembrane protein 200A - Homo sapiens (Human) - TMEM200A gene Taurus_UMD|evm.model.AC_000166.1.353 H3BR10 SMLR1_HUMAN 81.395 0.341463 1.14953 SMLR1 - Small leucine-rich protein 1 - Homo sapiens (Human) - SMLR1 gene Taurus_UMD|evm.model.AC_000166.1.354 O43491 E41L2_HUMAN 83.506 0.998088 1.0408 EPB41L2 - Band 4.1-like protein 2 - Homo sapiens (Human) - EPB41L2 gene Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). Taurus_UMD|evm.model.AC_000166.1.355 Q9P0M2 AKA7G_HUMAN 85.200 0.992032 0.721264 AKAP7 - A-kinase anchor protein 7 isoform gamma - Homo sapiens (Human) - AKAP7 gene Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. Taurus_UMD|evm.model.AC_000166.1.356 Q2KJ64 ARGI1_BOVIN 100.000 0.993808 1.00311 ARG1 - Arginase-1 - Bos taurus (Bovine) - ARG1 gene cytoplasm, cytosol, arginase activity, manganese ion binding, arginine catabolic process to ornithine Taurus_UMD|evm.model.AC_000166.1.357 Q9ULK4 MED23_HUMAN 96.711 0.996318 0.99269 MED23 - Mediator of RNA polymerase II transcription subunit 23 - Homo sapiens (Human) - MED23 gene Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. Taurus_UMD|evm.model.AC_000166.1.358 P15396 ENPP3_BOVIN 100.000 0.911221 0.927918 ENPP3 - Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 - Bos taurus (Bovine) - ENPP3 gene Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has also alkaline phosphodiesterase activity (By similarity). Taurus_UMD|evm.model.AC_000166.1.359 P22413 ENPP1_HUMAN 87.027 0.997838 1 ENPP1 - Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 - Homo sapiens (Human) - ENPP1 gene Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels (By similarity). PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals (PubMed:11004006). Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP (PubMed:27467858, PubMed:8001561, PubMed:25344812). May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling (PubMed:27467858, PubMed:8001561). Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect (By similarity). Appears to modulate insulin sensitivity and function (PubMed:10615944). Also involved in melanogenesis (PubMed:28964717). Also able to hydrolyze 2'-3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production (PubMed:25344812). 2'-3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced; the role of 2'-3'-cGAMP hydrolysis is therefore unclear (PubMed:25344812). Not able to hydrolyze the 2'-3'-cGAMP linkage isomer 3'-3'-cGAMP (PubMed:25344812). Taurus_UMD|evm.model.AC_000166.1.360 O18739 CCN2_BOVIN 100.000 0.994286 1.00287 CCN2 - CCN family member 2 precursor - Bos taurus (Bovine) - CCN2 gene Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity). Taurus_UMD|evm.model.AC_000166.1.361 A0JN40 KIF3C_BOVIN 80.606 0.806931 0.255051 KIF3C - Kinesin-like protein KIF3C - Bos taurus (Bovine) - KIF3C gene Microtubule-based anterograde translocator for membranous organelles. Taurus_UMD|evm.model.AC_000166.1.362 Q6UVY6 MOXD1_HUMAN 94.194 0.646444 0.779772 MOXD1 - DBH-like monooxygenase protein 1 precursor - Homo sapiens (Human) - MOXD1 gene endoplasmic reticulum membrane, extracellular space, secretory granule membrane, copper ion binding, dopamine beta-monooxygenase activity, dopamine catabolic process, norepinephrine biosynthetic process, octopamine biosynthetic process Taurus_UMD|evm.model.AC_000166.1.363 Q6YP21 KAT3_HUMAN 90.000 0.474403 0.645374 KYAT3 - Kynurenine--oxoglutarate transaminase 3 - Homo sapiens (Human) - KYAT3 gene Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro). Taurus_UMD|evm.model.AC_000166.1.364 Q3ZBT5 STX7_BOVIN 100.000 0.992366 1.00383 STX7 - Syntaxin-7 - Bos taurus (Bovine) - STX7 gene May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity). Taurus_UMD|evm.model.AC_000166.1.365 Q5QD11 TAA7B_MOUSE 75.862 0.643785 1.50559 Taar7b - Trace amine-associated receptor 7b - Mus musculus (Mouse) - Taar7b gene Orphan olfactory receptor specific for trace amines. Taurus_UMD|evm.model.AC_000166.1.366 Q96RI8 TAAR6_HUMAN 83.774 0.988764 0.773913 TAAR6 - Trace amine-associated receptor 6 - Homo sapiens (Human) - TAAR6 gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. Taurus_UMD|evm.model.AC_000166.1.367 Q923Y5 TAAR6_RAT 81.522 0.91 0.289855 Taar6 - Trace amine-associated receptor 6 - Rattus norvegicus (Rat) - Taar6 gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. Taurus_UMD|evm.model.AC_000166.1.368 Q923Y2 TAA7A_RAT 79.012 0.56338 0.396648 Taar7a - Trace amine-associated receptor 7a - Rattus norvegicus (Rat) - Taar7a gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. Taurus_UMD|evm.model.AC_000166.1.369 Q969N4 TAAR8_HUMAN 47.644 0.981132 0.464912 TAAR8 - Trace amine-associated receptor 8 - Homo sapiens (Human) - TAAR8 gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. Taurus_UMD|evm.model.AC_000166.1.370 Q5QD12 TAA7A_MOUSE 80.415 0.976744 0.960894 Taar7a - Trace amine-associated receptor 7a - Mus musculus (Mouse) - Taar7a gene Orphan olfactory receptor specific for trace amines. Taurus_UMD|evm.model.AC_000166.1.371 Q96RI8 TAAR6_HUMAN 83.841 0.451034 2.10145 TAAR6 - Trace amine-associated receptor 6 - Homo sapiens (Human) - TAAR6 gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. Taurus_UMD|evm.model.AC_000166.1.372 Q5W8W0 TAAR6_PANTR 85.423 0.9 1.10145 TAAR6 - Trace amine-associated receptor 6 - Pan troglodytes (Chimpanzee) - TAAR6 gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood (By similarity). Taurus_UMD|evm.model.AC_000166.1.373 Q5QD10 TAA7D_MOUSE 74.783 0.966245 0.662011 Taar7d - Trace amine-associated receptor 7d - Mus musculus (Mouse) - Taar7d gene Orphan olfactory receptor specific for trace amines. Taurus_UMD|evm.model.AC_000166.1.374 Q5QD12 TAA7A_MOUSE 78.806 0.97093 0.960894 Taar7a - Trace amine-associated receptor 7a - Mus musculus (Mouse) - Taar7a gene Orphan olfactory receptor specific for trace amines. Taurus_UMD|evm.model.AC_000166.1.375 Q5QD13 TAAR6_MOUSE 84.928 0.99422 1.0029 Taar6 - Trace amine-associated receptor 6 - Mus musculus (Mouse) - Taar6 gene Orphan olfactory receptor specific for trace amines. Taurus_UMD|evm.model.AC_000166.1.376 Q5QD10 TAA7D_MOUSE 70.448 0.96732 0.854749 Taar7d - Trace amine-associated receptor 7d - Mus musculus (Mouse) - Taar7d gene Orphan olfactory receptor specific for trace amines. Taurus_UMD|evm.model.AC_000166.1.377 Q5W8W0 TAAR6_PANTR 79.300 0.977011 1.0087 TAAR6 - Trace amine-associated receptor 6 - Pan troglodytes (Chimpanzee) - TAAR6 gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood (By similarity). Taurus_UMD|evm.model.AC_000166.1.378 Q5QD12 TAA7A_MOUSE 78.006 0.988372 0.960894 Taar7a - Trace amine-associated receptor 7a - Mus musculus (Mouse) - Taar7a gene Orphan olfactory receptor specific for trace amines. Taurus_UMD|evm.model.AC_000166.1.379 Q5W8W0 TAAR6_PANTR 86.804 0.991254 0.994203 TAAR6 - Trace amine-associated receptor 6 - Pan troglodytes (Chimpanzee) - TAAR6 gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood (By similarity). Taurus_UMD|evm.model.AC_000166.1.380 Q96RI8 TAAR6_HUMAN 80.328 0.0988468 1.75942 TAAR6 - Trace amine-associated receptor 6 - Homo sapiens (Human) - TAAR6 gene Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. Taurus_UMD|evm.model.AC_000166.1.381 Q5QD14 TAAR5_MOUSE 85.460 0.994083 1.00297 Taar5 - Trace amine-associated receptor 5 - Mus musculus (Mouse) - Taar5 gene Olfactory receptor specific for trimethylamine, a trace amine enriched in the urine of male mice, playing a role in social behavior. Trimethylamine is present at high concentration in the urine of male mice after puberty and acts as an attractant. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase. Taurus_UMD|evm.model.AC_000166.1.382 Q9P1P5 TAAR2_HUMAN 91.031 0.467368 1.35328 TAAR2 - Trace amine-associated receptor 2 - Homo sapiens (Human) - TAAR2 gene Orphan receptor. Taurus_UMD|evm.model.AC_000166.1.383 Q58CQ9 VNN1_BOVIN 99.608 0.791602 1.26078 VNN1 - Pantetheinase precursor - Bos taurus (Bovine) - VNN1 gene Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Taurus_UMD|evm.model.AC_000166.1.384 O95498 VNN2_HUMAN 79.423 0.996161 1.00192 VNN2 - Vascular non-inflammatory molecule 2 precursor - Homo sapiens (Human) - VNN2 gene Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil. Taurus_UMD|evm.model.AC_000166.1.385 Q6NT16 S18B1_HUMAN 83.937 0.950431 1.01754 SLC18B1 - MFS-type transporter SLC18B1 - Homo sapiens (Human) - SLC18B1 gene transmembrane transporter activity Taurus_UMD|evm.model.AC_000166.1.386 P46405 RS12_PIG 100.000 0.984962 1.00758 RPS12 - 40S ribosomal protein S12 - Sus scrofa (Pig) - RPS12 gene cytosolic small ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000166.1.388 Q9Z191 EYA4_MOUSE 94.805 0.996759 1.00162 Eya4 - Eyes absent homolog 4 - Mus musculus (Mouse) - Eya4 gene Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). Taurus_UMD|evm.model.AC_000166.1.390 Q5E9S3 TCF21_BOVIN 100.000 0.988889 1.00559 TCF21 - Transcription factor 21 - Bos taurus (Bovine) - TCF21 gene Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types (By similarity). Taurus_UMD|evm.model.AC_000166.1.391 Q5R7U8 TBPL1_PONAB 100.000 0.989305 0.984211 TBPL1 - TATA box-binding protein-like 1 - Pongo abelii (Sumatran orangutan) - TBPL1 gene Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity). Taurus_UMD|evm.model.AC_000166.1.392 Q5J316 GTR12_BOVIN 91.897 0.996296 0.869565 SLC2A12 - Solute carrier family 2, facilitated glucose transporter member 12 - Bos taurus (Bovine) - SLC2A12 gene Insulin-independent facilitative glucose transporter. Taurus_UMD|evm.model.AC_000166.1.393 A7MB74 SGK1_BOVIN 100.000 0.768501 1.22274 SGK1 - Serine/threonine-protein kinase Sgk1 - Bos taurus (Bovine) - SGK1 gene Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis (By similarity). Taurus_UMD|evm.model.AC_000166.1.395 P62074 TIM10_RAT 87.671 0.972973 0.822222 Timm10 - Mitochondrial import inner membrane translocase subunit Tim10 - Rattus norvegicus (Rat) - Timm10 gene Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). Taurus_UMD|evm.model.AC_000166.1.396 Q5R997 SPIN1_PONAB 72.031 0.9875 0.916031 SPIN1 - Spindlin-1 - Pongo abelii (Sumatran orangutan) - SPIN1 gene Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. Taurus_UMD|evm.model.AC_000166.1.397 Q0P5F9 AL8A1_BOVIN 99.795 0.995902 1.00205 ALDH8A1 - 2-aminomuconic semialdehyde dehydrogenase - Bos taurus (Bovine) - ALDH8A1 gene Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. Taurus_UMD|evm.model.AC_000166.1.398 Q2KHZ2 HBS1L_BOVIN 99.854 0.997089 1.00146 HBS1L - HBS1-like protein - Bos taurus (Bovine) - HBS1L gene Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway. Taurus_UMD|evm.model.AC_000166.1.399 P46200 MYB_BOVIN 99.751 0.524934 1.19063 MYB - Transcriptional activator Myb - Bos taurus (Bovine) - MYB gene Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. Taurus_UMD|evm.model.AC_000166.1.400 Q8N157 AHI1_HUMAN 81.052 0.998295 0.980769 AHI1 - Jouberin - Homo sapiens (Human) - AHI1 gene Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382). Taurus_UMD|evm.model.AC_000166.1.401 Q9QXQ1 PDE7B_MOUSE 93.096 0.995556 1.00897 Pde7b - cAMP-specific 3',5'-cyclic phosphodiesterase 7B - Mus musculus (Mouse) - Pde7b gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain. Taurus_UMD|evm.model.AC_000166.1.402 Q58CR1 MTFR2_BOVIN 100.000 0.266962 3.70492 MTFR2 - Mitochondrial fission regulator 2 - Bos taurus (Bovine) - MTFR2 gene May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity). Taurus_UMD|evm.model.AC_000166.1.403 Q14244 MAP7_HUMAN 81.625 0.997301 0.989319 MAP7 - Ensconsin - Homo sapiens (Human) - MAP7 gene Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. Taurus_UMD|evm.model.AC_000166.1.406 P97865 PEX7_MOUSE 89.172 0.965625 1.00629 Pex7 - Peroxisomal targeting signal 2 receptor - Mus musculus (Mouse) - Pex7 gene Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import. Taurus_UMD|evm.model.AC_000166.1.407 Q5M8T2 S35D3_HUMAN 91.017 0.995283 1.01923 SLC35D3 - Solute carrier family 35 member D3 - Homo sapiens (Human) - SLC35D3 gene May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules. Taurus_UMD|evm.model.AC_000166.1.408 Q9UHF4 I20RA_HUMAN 75.522 0.937388 1.01085 IL20RA - Interleukin-20 receptor subunit alpha precursor - Homo sapiens (Human) - IL20RA gene The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26. Taurus_UMD|evm.model.AC_000166.1.409 Q969J5 I22R2_HUMAN 65.779 0.991342 0.878327 IL22RA2 - Interleukin-22 receptor subunit alpha-2 precursor - Homo sapiens (Human) - IL22RA2 gene Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Taurus_UMD|evm.model.AC_000166.1.410 P15260 INGR1_HUMAN 57.755 0.928144 1.02454 IFNGR1 - Interferon gamma receptor 1 precursor - Homo sapiens (Human) - IFNGR1 gene Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity). Taurus_UMD|evm.model.AC_000166.1.411 Q0VCA5 SAMH1_BOVIN 95.833 0.753165 0.268251 SAMHD1 - Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 - Bos taurus (Bovine) - SAMHD1 gene Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (By similarity). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity (By similarity). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools. Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication. Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation. Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (By similarity). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity). Taurus_UMD|evm.model.AC_000166.1.412 Q7RTU3 OLIG3_HUMAN 98.897 0.992674 1.00368 OLIG3 - Oligodendrocyte transcription factor 3 - Homo sapiens (Human) - OLIG3 gene May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons. Taurus_UMD|evm.model.AC_000166.1.414 Q4R8W3 TNAP3_MACFA 85.949 0.997439 0.988608 TNFAIP3 - Tumor necrosis factor alpha-induced protein 3 - Macaca fascicularis (Crab-eating macaque) - TNFAIP3 gene Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages (By similarity). Taurus_UMD|evm.model.AC_000166.1.415 Q96FX8 PERP_HUMAN 88.601 0.989189 0.958549 PERP - p53 apoptosis effector related to PMP-22 - Homo sapiens (Human) - PERP gene Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity). Taurus_UMD|evm.model.AC_000166.1.416 Q5TH69 BIG3_HUMAN 94.444 0.999081 1 ARFGEF3 - Brefeldin A-inhibited guanine nucleotide-exchange protein 3 - Homo sapiens (Human) - ARFGEF3 gene Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). Taurus_UMD|evm.model.AC_000166.1.417 A0A1B0GU29 SIM28_HUMAN 79.592 0.879518 1.09211 SMIM28 - Small integral membrane protein 28 - Homo sapiens (Human) - SMIM28 gene Taurus_UMD|evm.model.AC_000166.1.418 Q9Y5Z4 HEBP2_HUMAN 88.293 0.990291 1.00488 HEBP2 - Heme-binding protein 2 - Homo sapiens (Human) - HEBP2 gene Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Taurus_UMD|evm.model.AC_000166.1.419 Q5SYE7 NHSL1_HUMAN 74.088 0.940564 1.01366 NHSL1 - NHS-like protein 1 - Homo sapiens (Human) - NHSL1 gene cell differentiation Taurus_UMD|evm.model.AC_000166.1.420 Q8IWP9 CC28A_HUMAN 81.273 0.838608 1.15328 CCDC28A - Coiled-coil domain-containing protein 28A - Homo sapiens (Human) - CCDC28A gene Taurus_UMD|evm.model.AC_000166.1.421 Q008S8 ECT2L_HUMAN 79.514 0.985011 1.03319 ECT2L - Epithelial cell-transforming sequence 2 oncogene-like - Homo sapiens (Human) - ECT2L gene May act as a guanine nucleotide exchange factor (GEF). Taurus_UMD|evm.model.AC_000166.1.422 Q96D71 REPS1_HUMAN 94.849 0.997429 0.977387 REPS1 - RalBP1-associated Eps domain-containing protein 1 - Homo sapiens (Human) - REPS1 gene May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. Taurus_UMD|evm.model.AC_000166.1.423 Q3ZBN0 ABRAL_BOVIN 100.000 0.571429 1.7284 ABRACL - Costars family protein ABRACL - Bos taurus (Bovine) - ABRACL gene regulation of actin filament-based process Taurus_UMD|evm.model.AC_000166.1.424 Q9UBI9 HDC_HUMAN 96.272 0.991285 0.845304 HECA - Headcase protein homolog - Homo sapiens (Human) - HECA gene May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs. Taurus_UMD|evm.model.AC_000166.1.425 Q8N3L3 TXLNB_HUMAN 67.560 0.997199 1.04386 TXLNB - Beta-taxilin - Homo sapiens (Human) - TXLNB gene Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic. Taurus_UMD|evm.model.AC_000166.1.426 Q0VCT9 CITE2_BOVIN 100.000 0.992701 1.00366 CITED2 - Cbp/p300-interacting transactivator 2 - Bos taurus (Bovine) - CITED2 gene Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. Taurus_UMD|evm.model.AC_000166.1.429 Q2HJ94 DNJA2_BOVIN 98.701 0.697248 0.264563 DNAJA2 - DnaJ homolog subfamily A member 2 precursor - Bos taurus (Bovine) - DNAJA2 gene Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Taurus_UMD|evm.model.AC_000166.1.430 A6NMX2 I4E1B_HUMAN 84.810 0.6 0.53719 EIF4E1B - Eukaryotic translation initiation factor 4E type 1B - Homo sapiens (Human) - EIF4E1B gene Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure. Taurus_UMD|evm.model.AC_000166.1.432 P28336 NMBR_HUMAN 91.538 0.994885 1.00256 NMBR - Neuromedin-B receptor - Homo sapiens (Human) - NMBR gene Receptor for neuromedin-B. Taurus_UMD|evm.model.AC_000166.1.433 Q32L63 VTA1_BOVIN 99.349 0.993506 1.00326 VTA1 - Vacuolar protein sorting-associated protein VTA1 homolog - Bos taurus (Bovine) - VTA1 gene Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Taurus_UMD|evm.model.AC_000166.1.434 Q86SQ4 AGRG6_HUMAN 86.178 0.96 1.02375 ADGRG6 - Adhesion G-protein coupled receptor G6 precursor - Homo sapiens (Human) - ADGRG6 gene G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity). Taurus_UMD|evm.model.AC_000166.1.435 P31629 ZEP2_HUMAN 89.967 0.999181 0.998774 HIVEP2 - Transcription factor HIVEP2 - Homo sapiens (Human) - HIVEP2 gene This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. Taurus_UMD|evm.model.AC_000166.1.437 Q9NVV5 AIG1_HUMAN 97.059 0.991632 1.0042 AIG1 - Androgen-induced gene 1 protein - Homo sapiens (Human) - AIG1 gene Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). Taurus_UMD|evm.model.AC_000166.1.438 Q5E9J7 ADAT2_BOVIN 100.000 0.989583 1.00524 DEADC1 - tRNA-specific adenosine deaminase 2 - Bos taurus (Bovine) - DEADC1 gene Probably participates in deamination of adenosine-34 to inosine in many tRNAs. Taurus_UMD|evm.model.AC_000166.1.439 A6H7C2 PEX3_BOVIN 99.732 0.994652 1.00268 PEX3 - Peroxisomal biogenesis factor 3 - Bos taurus (Bovine) - PEX3 gene Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes (By similarity). Taurus_UMD|evm.model.AC_000166.1.440 Q9BTY2 FUCO2_HUMAN 86.788 0.939914 0.997859 FUCA2 - Plasma alpha-L-fucosidase precursor - Homo sapiens (Human) - FUCA2 gene Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Taurus_UMD|evm.model.AC_000166.1.442 O75167 PHAR2_HUMAN 92.414 0.255814 0.881703 PHACTR2 - Phosphatase and actin regulator 2 - Homo sapiens (Human) - PHACTR2 gene plasma membrane, platelet alpha granule membrane, actin binding, actin cytoskeleton organization, platelet degranulation Taurus_UMD|evm.model.AC_000166.1.443 Q0VC06 LTV1_BOVIN 100.000 0.995798 1.00211 LTV1 - Protein LTV1 homolog - Bos taurus (Bovine) - LTV1 gene cytosol, nucleus, preribosome, small subunit precursor, ribosomal small subunit biogenesis, ribosomal small subunit export from nucleus Taurus_UMD|evm.model.AC_000166.1.444 Q32KN7 ZC21B_BOVIN 99.095 0.990991 1.0137 ZC2HC1B - Zinc finger C2HC domain-containing protein 1B - Bos taurus (Bovine) - ZC2HC1B gene Taurus_UMD|evm.model.AC_000166.1.445 Q2I689 PLAL1_PIG 88.769 0.995652 0.993521 PLAGL1 - Zinc finger protein PLAGL1 - Sus scrofa (Pig) - PLAGL1 gene Acts as a transcriptional activator. Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide. Taurus_UMD|evm.model.AC_000166.1.446 Q9BWJ5 SF3B5_HUMAN 100.000 0.977011 1.01163 SF3B5 - Splicing factor 3B subunit 5 - Homo sapiens (Human) - SF3B5 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Taurus_UMD|evm.model.AC_000166.1.447 O75558 STX11_HUMAN 83.217 0.989583 1.00348 STX11 - Syntaxin-11 - Homo sapiens (Human) - STX11 gene SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. Taurus_UMD|evm.model.AC_000166.1.448 P46939 UTRO_HUMAN 91.818 0.990407 1.00204 UTRN - Utrophin - Homo sapiens (Human) - UTRN gene May play a role in anchoring the cytoskeleton to the plasma membrane. Taurus_UMD|evm.model.AC_000166.1.449 Q93079 H2B1H_HUMAN 92.929 0.823529 0.944444 H2BC9 - Histone H2B type 1-H - Homo sapiens (Human) - H2BC9 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000166.1.451 O95278 EPM2A_HUMAN 95.166 0.993976 1.00302 EPM2A - Laforin - Homo sapiens (Human) - EPM2A gene Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates (PubMed:16901901, PubMed:23922729, PubMed:26231210, PubMed:25538239, PubMed:25544560). Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro) (PubMed:11001928, PubMed:11220751, PubMed:11739371, PubMed:14532330, PubMed:16971387, PubMed:18617530, PubMed:22036712, PubMed:23922729, PubMed:14722920). Has been shown to dephosphorylate MAPT (By similarity). Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin (PubMed:23922729). Also promotes proteasome-independent protein degradation through the macroautophagy pathway (PubMed:20453062). Taurus_UMD|evm.model.AC_000166.1.452 Q8TB52 FBX30_HUMAN 90.909 0.997319 1.00134 FBXO30 - F-box only protein 30 - Homo sapiens (Human) - FBXO30 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation. Taurus_UMD|evm.model.AC_000166.1.453 Q149N8 SHPRH_HUMAN 90.569 0.982497 1.01842 SHPRH - E3 ubiquitin-protein ligase SHPRH - Homo sapiens (Human) - SHPRH gene E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. Taurus_UMD|evm.model.AC_000166.1.454 P97772 GRM1_MOUSE 97.152 0.923754 0.284404 Grm1 - Metabotropic glutamate receptor 1 precursor - Mus musculus (Mouse) - Grm1 gene G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity). May function in the light response in the retina (PubMed:26427409). Taurus_UMD|evm.model.AC_000166.1.455 Q13255 GRM1_HUMAN 91.714 0.997717 0.733668 GRM1 - Metabotropic glutamate receptor 1 precursor - Homo sapiens (Human) - GRM1 gene G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, PubMed:28886343, PubMed:7476890). May function in the light response in the retina (By similarity). Taurus_UMD|evm.model.AC_000166.1.456 Q06AU5 RAB32_PIG 93.204 0.90708 1 RAB32 - Ras-related protein Rab-32 - Sus scrofa (Pig) - RAB32 gene Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Taurus_UMD|evm.model.AC_000166.1.457 Q1RMS8 FBX25_BOVIN 94.615 0.759531 0.955182 FBXO25 - F-box only protein 25 - Bos taurus (Bovine) - FBXO25 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). Taurus_UMD|evm.model.AC_000166.1.458 Q3SZB4 ACADM_BOVIN 100.000 0.0205405 4.3943 ACADM - Medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ACADM gene Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains. Taurus_UMD|evm.model.AC_000166.1.459 Q5T5C0 STXB5_HUMAN 97.830 0.998265 1.00174 STXBP5 - Syntaxin-binding protein 5 - Homo sapiens (Human) - STXBP5 gene Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). Taurus_UMD|evm.model.AC_000166.1.460 Q9BZM4 ULBP3_HUMAN 47.788 0.931624 0.479508 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000166.1.461 Q09YL6 SAMD5_BOVIN 100.000 0.950617 0.925714 SAMD5 - Sterile alpha motif domain-containing protein 5 - Bos taurus (Bovine) - SAMD5 gene cytoplasm Taurus_UMD|evm.model.AC_000166.1.462 Q9BZM4 ULBP3_HUMAN 49.505 0.681356 1.20902 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000166.1.463 Q32KW0 NFYB_BOVIN 99.512 0.971429 1.01449 NFYB - Nuclear transcription factor Y subunit beta - Bos taurus (Bovine) - NFYB gene Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors (By similarity). Taurus_UMD|evm.model.AC_000166.1.464 Q5SVS4 KMCP1_HUMAN 94.118 0.921875 0.439863 SLC25A30 - Kidney mitochondrial carrier protein 1 - Homo sapiens (Human) - SLC25A30 gene Probable transporter. Taurus_UMD|evm.model.AC_000166.1.467 O94885 SASH1_HUMAN 87.783 0.862039 0.935846 SASH1 - SAM and SH3 domain-containing protein 1 - Homo sapiens (Human) - SASH1 gene Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). Taurus_UMD|evm.model.AC_000166.1.468 Q9Y2C2 UST_HUMAN 85.446 0.789474 0.655172 UST - Uronyl 2-sulfotransferase - Homo sapiens (Human) - UST gene Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin. Taurus_UMD|evm.model.AC_000166.1.469 Q9Y2C2 UST_HUMAN 94.253 0.716667 0.295567 UST - Uronyl 2-sulfotransferase - Homo sapiens (Human) - UST gene Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin. Taurus_UMD|evm.model.AC_000166.1.470 Q9NYJ8 TAB2_HUMAN 96.681 0.997118 1.00144 TAB2 - TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 - Homo sapiens (Human) - TAB2 gene Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:22158122). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459). Taurus_UMD|evm.model.AC_000166.1.472 A2A288 ZC12D_HUMAN 69.017 0.994297 0.998102 ZC3H12D - Probable ribonuclease ZC3H12D - Homo sapiens (Human) - ZC3H12D gene May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561). Taurus_UMD|evm.model.AC_000166.1.473 Q8WUA2 PPIL4_HUMAN 97.561 0.995943 1.00203 PPIL4 - Peptidyl-prolyl cis-trans isomerase-like 4 - Homo sapiens (Human) - PPIL4 gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Taurus_UMD|evm.model.AC_000166.1.474 Q5RBQ2 GINM1_PONAB 87.311 0.993939 1 GINM1 - Glycoprotein integral membrane protein 1 precursor - Pongo abelii (Sumatran orangutan) - GINM1 gene Taurus_UMD|evm.model.AC_000166.1.475 O75449 KTNA1_HUMAN 97.149 0.995935 1.00204 KATNA1 - Katanin p60 ATPase-containing subunit A1 - Homo sapiens (Human) - KATNA1 gene Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. Taurus_UMD|evm.model.AC_000166.1.477 O95835 LATS1_HUMAN 94.956 0.998221 0.99469 LATS1 - Serine/threonine-protein kinase LATS1 - Homo sapiens (Human) - LATS1 gene Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Taurus_UMD|evm.model.AC_000166.1.478 P19338 NUCL_HUMAN 87.324 0.188503 1.05352 NCL - Nucleolin - Homo sapiens (Human) - NCL gene Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Taurus_UMD|evm.model.AC_000166.1.479 Q8NFH3 NUP43_HUMAN 93.784 0.87234 1.11316 NUP43 - Nucleoporin Nup43 - Homo sapiens (Human) - NUP43 gene Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. Taurus_UMD|evm.model.AC_000166.1.480 P15246 PIMT_BOVIN 100.000 0.672673 1.46696 PCMT1 - Protein-L-isoaspartate(D-aspartate) O-methyltransferase - Bos taurus (Bovine) - PCMT1 gene Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein. Taurus_UMD|evm.model.AC_000166.1.481 Q86VZ4 LRP11_HUMAN 79.352 0.907063 0.538 LRP11 - Low-density lipoprotein receptor-related protein 11 precursor - Homo sapiens (Human) - LRP11 gene plasma membrane, phosphoprotein binding Taurus_UMD|evm.model.AC_000166.1.482 Q2YDJ0 NUSAP_BOVIN 97.849 0.99568 0.995699 NUSAP1 - Nucleolar and spindle-associated protein 1 - Bos taurus (Bovine) - NUSAP1 gene Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them (By similarity). Taurus_UMD|evm.model.AC_000166.1.483 Q86VZ4 LRP11_HUMAN 72.459 0.986301 0.584 LRP11 - Low-density lipoprotein receptor-related protein 11 precursor - Homo sapiens (Human) - LRP11 gene plasma membrane, phosphoprotein binding Taurus_UMD|evm.model.AC_000166.1.484 Q9BZM5 ULBP2_HUMAN 48.235 0.571429 0.597561 ULBP2 - UL16-binding protein 2 precursor - Homo sapiens (Human) - ULBP2 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000166.1.485 Q9BZM4 ULBP3_HUMAN 43.478 0.535294 0.696721 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000166.1.486 Q9BZM4 ULBP3_HUMAN 52.336 0.758007 1.15164 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000166.1.487 Q9BZM4 ULBP3_HUMAN 52.459 0.647687 1.15164 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000166.1.488 Q9BZM4 ULBP3_HUMAN 48.485 0.693662 1.16393 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000166.1.489 Q9BZM5 ULBP2_HUMAN 48.634 0.627586 1.17886 ULBP2 - UL16-binding protein 2 precursor - Homo sapiens (Human) - ULBP2 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000166.1.490 Q8TD07 RAE1E_HUMAN 45.370 0.894737 0.43346 RAET1E - Retinoic acid early transcript 1E precursor - Homo sapiens (Human) - RAET1E gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000166.1.491 Q8TAE6 PP14C_HUMAN 90.476 0.988166 1.02424 PPP1R14C - Protein phosphatase 1 regulatory subunit 14C - Homo sapiens (Human) - PPP1R14C gene Inhibitor of the PP1 regulatory subunit PPP1CA. Taurus_UMD|evm.model.AC_000166.1.492 Q6TA49 IYD1_PIG 87.413 0.681928 1.43599 IYD - Iodotyrosine deiodinase 1 precursor - Sus scrofa (Pig) - IYD gene Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT) (PubMed:15289438). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine. Taurus_UMD|evm.model.AC_000166.1.493 Q8TD07 RAE1E_HUMAN 54.595 0.432941 1.61597 RAET1E - Retinoic acid early transcript 1E precursor - Homo sapiens (Human) - RAET1E gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000166.1.494 Q9DCX8 IYD1_MOUSE 83.607 0.869565 0.242105 Iyd - Iodotyrosine deiodinase 1 precursor - Mus musculus (Mouse) - Iyd gene Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT) (PubMed:22238141). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine (By similarity). Taurus_UMD|evm.model.AC_000166.1.496 Q9ULL1 PKHG1_HUMAN 81.694 0.998552 0.997112 PLEKHG1 - Pleckstrin homology domain-containing family G member 1 - Homo sapiens (Human) - PLEKHG1 gene nucleoplasm Taurus_UMD|evm.model.AC_000166.1.497 Q0VCR7 C1TM_BOVIN 84.298 0.95397 0.891282 MTHFD1L - Monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor - Bos taurus (Bovine) - MTHFD1L gene May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. Taurus_UMD|evm.model.AC_000166.1.498 Q02952 AKA12_HUMAN 62.614 0.955215 0.989899 AKAP12 - A-kinase anchor protein 12 - Homo sapiens (Human) - AKAP12 gene Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). Taurus_UMD|evm.model.AC_000166.1.499 Q8N680 ZBTB2_HUMAN 96.498 0.996117 1.00195 ZBTB2 - Zinc finger and BTB domain-containing protein 2 - Homo sapiens (Human) - ZBTB2 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000166.1.500 Q9NWS8 RMND1_HUMAN 86.860 0.984581 1.01114 RMND1 - Required for meiotic nuclear division protein 1 homolog precursor - Homo sapiens (Human) - RMND1 gene Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome (PubMed:23022098, PubMed:25604853). Taurus_UMD|evm.model.AC_000166.1.501 A3KMX8 ARMT1_BOVIN 99.773 0.995475 1.00227 ARMT1 - Damage-control phosphatase ARMT1 - Bos taurus (Bovine) - ARMT1 gene Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (By similarity). Taurus_UMD|evm.model.AC_000166.1.502 Q8IYT3 CC170_HUMAN 72.113 0.980273 0.921678 CCDC170 - Coiled-coil domain-containing protein 170 - Homo sapiens (Human) - CCDC170 gene Plays a role in Golgi-associated microtubules organization and stabilization. Taurus_UMD|evm.model.AC_000166.1.503 P49884 ESR1_BOVIN 100.000 0.971154 0.174497 ESR1 - Estrogen receptor - Bos taurus (Bovine) - ESR1 gene Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity). Taurus_UMD|evm.model.AC_000166.1.504 P49884 ESR1_BOVIN 100.000 0.984444 0.755034 ESR1 - Estrogen receptor - Bos taurus (Bovine) - ESR1 gene Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity). Taurus_UMD|evm.model.AC_000166.1.505 Q8NF91 SYNE1_HUMAN 89.910 0.999513 0.466523 SYNE1 - Nesprin-1 - Homo sapiens (Human) - SYNE1 gene Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. Taurus_UMD|evm.model.AC_000166.1.506 Q8NF91 SYNE1_HUMAN 89.777 0.994863 0.53109 SYNE1 - Nesprin-1 - Homo sapiens (Human) - SYNE1 gene Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. Taurus_UMD|evm.model.AC_000166.1.507 Q8N699 MYCT1_HUMAN 86.826 0.988024 0.710638 MYCT1 - Myc target protein 1 - Homo sapiens (Human) - MYCT1 gene May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity). Taurus_UMD|evm.model.AC_000166.1.508 P81401 VIP_BOVIN 100.000 0.988304 1.00588 VIP - VIP peptides precursor - Bos taurus (Bovine) - VIP gene VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. Taurus_UMD|evm.model.AC_000166.1.510 Q2KI15 RF1ML_BOVIN 99.737 0.994751 1.00263 MTRF1L - Peptide chain release factor 1-like, mitochondrial precursor - Bos taurus (Bovine) - MTRF1L gene Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG. Taurus_UMD|evm.model.AC_000166.1.511 Q9UGC6 RGS17_HUMAN 82.857 0.94709 0.9 RGS17 - Regulator of G-protein signaling 17 - Homo sapiens (Human) - RGS17 gene Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:15096504). Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). Taurus_UMD|evm.model.AC_000166.1.514 Q8NH72 OR4C6_HUMAN 67.857 0.990323 1.00324 OR4C6 - Olfactory receptor 4C6 - Homo sapiens (Human) - OR4C6 gene Odorant receptor. Taurus_UMD|evm.model.AC_000166.1.515 P13383 NUCL_RAT 56.627 0.842105 0.346424 Ncl - Nucleolin - Rattus norvegicus (Rat) - Ncl gene Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity). Taurus_UMD|evm.model.AC_000166.1.516 Q8WY07 CTR3_HUMAN 56.223 0.946721 0.394184 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000166.1.517 P79350 OPRM_BOVIN 99.487 0.98731 0.982544 OPRM1 - Mu-type opioid receptor - Bos taurus (Bovine) - OPRM1 gene Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:10581406). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis (By similarity). Taurus_UMD|evm.model.AC_000166.1.518 Q8WWN9 ICEF1_HUMAN 80.182 0.993135 1 IPCEF1 - Interactor protein for cytohesin exchange factors 1 - Homo sapiens (Human) - IPCEF1 gene Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. Taurus_UMD|evm.model.AC_000166.1.520 G9CGD6 CNIPF_HUMAN 95.186 0.81982 0.617353 CNK3/IPCEF1 - CNK3/IPCEF1 fusion protein - Homo sapiens (Human) - CNK3/IPCEF1 gene Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration. Taurus_UMD|evm.model.AC_000166.1.521 P18437 HMGN2_RAT 77.922 0.72381 1.16667 Hmgn2 - Non-histone chromosomal protein HMG-17 - Rattus norvegicus (Rat) - Hmgn2 gene Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). Taurus_UMD|evm.model.AC_000166.1.523 Q9UPN6 SCAF8_HUMAN 95.279 0.998424 0.998426 SCAF8 - SR-related and CTD-associated factor 8 - Homo sapiens (Human) - SCAF8 gene Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF4, also acts as a positive regulator of transcript elongation (PubMed:31104839). Taurus_UMD|evm.model.AC_000166.1.524 Q8NFU3 TSTD1_HUMAN 75.410 0.361446 1.44348 TSTD1 - Thiosulfate:glutathione sulfurtransferase - Homo sapiens (Human) - TSTD1 gene Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631). Taurus_UMD|evm.model.AC_000166.1.526 Q8IVF5 TIAM2_HUMAN 86.792 0.357323 0.931217 TIAM2 - Rho guanine nucleotide exchange factor TIAM2 - Homo sapiens (Human) - TIAM2 gene Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. Taurus_UMD|evm.model.AC_000166.1.527 Q2TBQ0 TFB1M_BOVIN 100.000 0.526163 1.0088 TFB1M - Mitochondrial dimethyladenosine transferase 1 precursor - Bos taurus (Bovine) - TFB1M gene S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity). Taurus_UMD|evm.model.AC_000166.1.528 Q9HBY0 NOX3_HUMAN 82.752 0.90636 0.996479 NOX3 - NADPH oxidase 3 - Homo sapiens (Human) - NOX3 gene NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Taurus_UMD|evm.model.AC_000166.1.529 Q96LI6 HSFY1_HUMAN 49.012 0.873684 0.710723 HSFY1 - Heat shock transcription factor, Y-linked - Homo sapiens (Human) - HSFY1 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000166.1.530 P00348 HCDH_PIG 85.446 0.942222 0.716561 HADH - Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor - Sus scrofa (Pig) - HADH gene Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:9593854, PubMed:2817332). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Taurus_UMD|evm.model.AC_000166.1.533 Q7PNC0 TMA7_ANOGA 61.905 0.561644 1.14062 AGAP008008 - Translation machinery-associated protein 7 homolog - Anopheles gambiae (African malaria mosquito) - AGAP008008 gene cytoplasmic translation Taurus_UMD|evm.model.AC_000166.1.534 E9Q4N7 ARI1B_MOUSE 91.718 0.998869 0.787879 Arid1b - AT-rich interactive domain-containing protein 1B - Mus musculus (Mouse) - Arid1b gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Binds DNA non-specifically. Taurus_UMD|evm.model.AC_000166.1.535 Q5R987 TM242_PONAB 87.234 0.985915 1.00709 TMEM242 - Transmembrane protein 242 - Pongo abelii (Sumatran orangutan) - TMEM242 gene Taurus_UMD|evm.model.AC_000166.1.536 Q8IZN3 ZDH14_HUMAN 93.139 0.995708 0.954918 ZDHHC14 - Palmitoyltransferase ZDHHC14 - Homo sapiens (Human) - ZDHHC14 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and thereby regulate G protein-coupled receptor signaling (PubMed:27481942). May play a role in cell differentiation and apoptosis (PubMed:21151021, PubMed:24407904). Taurus_UMD|evm.model.AC_000166.1.537 Q9Y5X1 SNX9_HUMAN 92.857 0.996593 0.986555 SNX9 - Sorting nexin-9 - Homo sapiens (Human) - SNX9 gene Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. Taurus_UMD|evm.model.AC_000166.1.538 O15056 SYNJ2_HUMAN 83.197 0.978983 0.985963 SYNJ2 - Synaptojanin-2 - Homo sapiens (Human) - SYNJ2 gene Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. Taurus_UMD|evm.model.AC_000166.1.539 Q2TBM9 SRAC1_BOVIN 100.000 0.996947 1.00153 SERAC1 - Protein SERAC1 - Bos taurus (Bovine) - SERAC1 gene Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway (By similarity). Taurus_UMD|evm.model.AC_000166.1.540 Q6ZYL4 TF2H5_HUMAN 100.000 0.972222 1.01408 GTF2H5 - General transcription factor IIH subunit 5 - Homo sapiens (Human) - GTF2H5 gene Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell. Taurus_UMD|evm.model.AC_000166.1.541 Q9JIL5 TULP4_MOUSE 93.730 0.657005 0.936652 Tulp4 - Tubby-related protein 4 - Mus musculus (Mouse) - Tulp4 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000166.1.543 Q9P2C4 TM181_HUMAN 87.288 0.798214 0.915033 TMEM181 - Transmembrane protein 181 - Homo sapiens (Human) - TMEM181 gene Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication. Taurus_UMD|evm.model.AC_000166.1.544 P63172 DYLT1_HUMAN 100.000 0.982456 1.00885 DYNLT1 - Dynein light chain Tctex-type 1 - Homo sapiens (Human) - DYNLT1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. Taurus_UMD|evm.model.AC_000166.1.545 Q4VX76 SYTL3_HUMAN 77.614 0.996732 1.00328 SYTL3 - Synaptotagmin-like protein 3 - Homo sapiens (Human) - SYTL3 gene May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity). Taurus_UMD|evm.model.AC_000166.1.546 P31976 EZRI_BOVIN 100.000 0.996564 1.00172 EZR - Ezrin - Bos taurus (Bovine) - EZR gene Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). Taurus_UMD|evm.model.AC_000166.1.547 A8E4N3 RSPH3_BOVIN 100.000 0.996705 1.00165 RSPH3 - Radial spoke head protein 3 homolog - Bos taurus (Bovine) - RSPH3 gene Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (By similarity). Taurus_UMD|evm.model.AC_000166.1.548 P62246 RS15A_RAT 76.344 0.978723 0.723077 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Taurus_UMD|evm.model.AC_000166.1.549 Q8N103 TAGAP_HUMAN 65.940 0.741701 1.31874 TAGAP - T-cell activation Rho GTPase-activating protein - Homo sapiens (Human) - TAGAP gene May function as a GTPase-activating protein and may play important roles during T-cell activation. Taurus_UMD|evm.model.AC_000166.1.550 Q4ZHG4 FNDC1_HUMAN 90.625 0.212188 0.95301 FNDC1 - Fibronectin type III domain-containing protein 1 precursor - Homo sapiens (Human) - FNDC1 gene May be an activator of G protein signaling. Taurus_UMD|evm.model.AC_000166.1.552 A6NHX0 CAST2_HUMAN 57.534 0.743056 0.87538 CASTOR2 - Cytosolic arginine sensor for mTORC1 subunit 2 - Homo sapiens (Human) - CASTOR2 gene Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. Taurus_UMD|evm.model.AC_000166.1.553 P41976 SODM_BOVIN 100.000 0.14752 3.45045 SOD2 - Superoxide dismutase [Mn], mitochondrial precursor - Bos taurus (Bovine) - SOD2 gene Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Taurus_UMD|evm.model.AC_000166.1.554 Q9BWD1 THIC_HUMAN 90.152 0.992462 1.00252 ACAT2 - Acetyl-CoA acetyltransferase, cytosolic - Homo sapiens (Human) - ACAT2 gene Involved in the biosynthetic pathway of cholesterol. Taurus_UMD|evm.model.AC_000166.1.555 Q32L40 TCPA_BOVIN 99.820 0.996409 1.0018 TCP1 - T-complex protein 1 subunit alpha - Bos taurus (Bovine) - TCP1 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Taurus_UMD|evm.model.AC_000166.1.556 Q3ZBR7 RM18_BOVIN 100.000 0.98895 1.00556 MRPL18 - 39S ribosomal protein L18, mitochondrial precursor - Bos taurus (Bovine) - MRPL18 gene Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity). Taurus_UMD|evm.model.AC_000166.1.557 B2RXZ1 PNDC1_MOUSE 87.287 0.988722 1.00188 Pnldc1 - Poly(A)-specific ribonuclease PNLDC1 - Mus musculus (Mouse) - Pnldc1 gene 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells (PubMed:27515512). Taurus_UMD|evm.model.AC_000166.1.559 P04201 MAS_HUMAN 87.385 0.993865 1.00308 MAS1 - Proto-oncogene Mas - Homo sapiens (Human) - MAS1 gene Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. Taurus_UMD|evm.model.AC_000166.1.560 P08169 MPRI_BOVIN 93.555 0.954274 0.201281 IGF2R - Cation-independent mannose-6-phosphate receptor precursor - Bos taurus (Bovine) - IGF2R gene Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. Taurus_UMD|evm.model.AC_000166.1.561 P08169 MPRI_BOVIN 94.444 0.825641 0.0780312 IGF2R - Cation-independent mannose-6-phosphate receptor precursor - Bos taurus (Bovine) - IGF2R gene Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. Taurus_UMD|evm.model.AC_000166.1.562 P08169 MPRI_BOVIN 99.895 0.985996 0.771509 IGF2R - Cation-independent mannose-6-phosphate receptor precursor - Bos taurus (Bovine) - IGF2R gene Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. Taurus_UMD|evm.model.AC_000166.1.563 A7MBE0 S22A1_BOVIN 100.000 0.996454 1.00178 SLC22A1 - Solute carrier family 22 member 1 - Bos taurus (Bovine) - SLC22A1 gene Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase (By similarity). Taurus_UMD|evm.model.AC_000166.1.564 O02713 S22A2_PIG 88.809 0.996364 0.99278 SLC22A2 - Solute carrier family 22 member 2 - Sus scrofa (Pig) - SLC22A2 gene Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity (By similarity). Taurus_UMD|evm.model.AC_000166.1.565 O75751 S22A3_HUMAN 93.728 0.996416 1.0036 SLC22A3 - Solute carrier family 22 member 3 - Homo sapiens (Human) - SLC22A3 gene Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. Taurus_UMD|evm.model.AC_000166.1.566 P06868 PLMN_BOVIN 99.261 0.99754 1.00123 PLG - Plasminogen precursor - Bos taurus (Bovine) - PLG gene Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity). Taurus_UMD|evm.model.AC_000166.1.567 P03709 FI_LAMBD 34.483 0.945055 0.689394 Fi - DNA-packaging protein FI - Escherichia phage lambda - Fi gene Stimulates the interaction of procapsid with the terminase-DNA complex, thereby increasing the overall rate of DNA packaging. Before packaging, it likely coats the surface of the procapsid through binding mediated by c-terminal domain. FI presumably dissociates from the capsid once it inflates upon DNA packaging, and is not present in the mature virion. Taurus_UMD|evm.model.AC_000166.1.568 Q9Y6R4 M3K4_HUMAN 91.299 0.974859 0.989428 MAP3K4 - Mitogen-activated protein kinase kinase kinase 4 - Homo sapiens (Human) - MAP3K4 gene Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. Taurus_UMD|evm.model.AC_000166.1.569 Q5E9R2 PLCD_BOVIN 99.735 0.994723 1.00265 AGPAT4 - 1-acyl-sn-glycerol-3-phosphate acyltransferase delta - Bos taurus (Bovine) - AGPAT4 gene Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity). Taurus_UMD|evm.model.AC_000166.1.571 O60260 PRKN_HUMAN 89.199 0.993056 0.619355 PRKN - E3 ubiquitin-protein ligase parkin - Homo sapiens (Human) - PRKN gene Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536, PubMed:32047033, PubMed:29311685, PubMed:22396657). Substrates include SYT11 and VDAC1 (PubMed:32047033, PubMed:29311685). Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2 (PubMed:10888878, PubMed:10973942, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:15105460, PubMed:16135753, PubMed:21376232, PubMed:21532592, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536, PubMed:22396657). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25621951, PubMed:32047033, PubMed:25474007). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMed:19229105). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed:11431533, PubMed:11590439, PubMed:15105460, PubMed:19229105, PubMed:15728840). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed:20889974). Protects against mitochondrial dysfunction during cellular stress, by acting downstream of PINK1 to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:32047033, PubMed:19029340, PubMed:19966284, PubMed:23620051, PubMed:24896179, PubMed:25527291, PubMed:18957282, PubMed:21376232, PubMed:22396657, PubMed:24660806, PubMed:25474007, PubMed:24784582, PubMed:11439185, PubMed:22082830, PubMed:23933751). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:32047033, PubMed:19029340, PubMed:19801972, PubMed:19966284, PubMed:23620051, PubMed:24896179, PubMed:25527291, PubMed:21376232, PubMed:22396657, PubMed:11439185, PubMed:22082830, PubMed:23933751, PubMed:33499712). Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires PINK1-mediated phosphorylation of both PRKN and ubiquitin (PubMed:24660806, PubMed:25474007, PubMed:24784582, PubMed:25527291). After mitochondrial damage, functions with PINK1 to mediate the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of VDAC1, respectively; polyubiquitination of VDAC1 promotes mitophagy, while monoubiquitination of VDAC1 decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1, MFN1 and USP30 (PubMed:19029340, PubMed:19966284, PubMed:23620051, PubMed:24896179, PubMed:25527291, PubMed:22396657, PubMed:23933751). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains, leading to mitophagy (PubMed:25621951, PubMed:32047033). The PINK1-PRKN pathway also promotes fission of damaged mitochondria by PINK1-mediated phosphorylation which promotes the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:23620051). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:23620051). Regulates motility of damaged mitochondria via the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Involved in mitochondrial biogenesis via the 'Lys-48'-linked polyubiquitination of transcriptional repressor ZNF746/PARIS which leads to its subsequent proteasomal degradation and allows activation of the transcription factor PPARGC1A (PubMed:21376232). Limits the production of reactive oxygen species (ROS) (PubMed:18541373). Regulates cyclin-E during neuronal apoptosis (PubMed:12628165). In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed:11439185). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene (PubMed:12719539). Taurus_UMD|evm.model.AC_000166.1.574 Q5W9D5 QKI_PIG 100.000 0.993031 0.841642 QKI - Protein quaking - Sus scrofa (Pig) - QKI gene RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). Taurus_UMD|evm.model.AC_000166.1.578 Q9H3K2 GHITM_HUMAN 92.245 0.907063 0.77971 GHITM - Growth hormone-inducible transmembrane protein precursor - Homo sapiens (Human) - GHITM gene Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c. Taurus_UMD|evm.model.AC_000166.1.580 Q5T5N4 CF118_HUMAN 58.085 0.932347 1.00853 C6orf118 - Uncharacterized protein C6orf118 - Homo sapiens (Human) - C6orf118 gene Taurus_UMD|evm.model.AC_000166.1.581 Q9Y233 PDE10_HUMAN 95.294 0.97318 1.00513 PDE10A - cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A - Homo sapiens (Human) - PDE10A gene Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition. Taurus_UMD|evm.model.AC_000166.1.587 Q9GL27 TBXT_CANLF 89.885 0.995413 1.0023 TBXT - T-box transcription factor T - Canis lupus familiaris (Dog) - TBXT gene Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site. Taurus_UMD|evm.model.AC_000166.1.591 Q8WV19 SFT2A_HUMAN 93.711 0.755981 1.31447 SFT2D1 - Vesicle transport protein SFT2A - Homo sapiens (Human) - SFT2D1 gene May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Taurus_UMD|evm.model.AC_000166.1.592 Q3ZCG2 MPC1_BOVIN 100.000 0.981818 1.00917 MPC1 - Mitochondrial pyruvate carrier 1 - Bos taurus (Bovine) - MPC1 gene Mediates the uptake of pyruvate into mitochondria. Taurus_UMD|evm.model.AC_000166.1.594 Q15349 KS6A2_HUMAN 96.601 0.986014 0.975443 RPS6KA2 - Ribosomal protein S6 kinase alpha-2 - Homo sapiens (Human) - RPS6KA2 gene Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. Taurus_UMD|evm.model.AC_000166.1.597 Q7M329 RNT2_PIG 66.667 0.862903 1.24 RNASET2 - Ribonuclease T2 - Sus scrofa (Pig) - RNASET2 gene Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. Plays also a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs. Taurus_UMD|evm.model.AC_000166.1.599 Q2YDD1 CEP43_BOVIN 99.455 0.97861 0.937343 CEP43 - Centrosomal protein 43 - Bos taurus (Bovine) - CEP43 gene Required for anchoring microtubules to the centrosomes. Required for ciliation. Taurus_UMD|evm.model.AC_000166.1.602 P51684 CCR6_HUMAN 78.933 0.709677 1.40909 CCR6 - C-C chemokine receptor type 6 - Homo sapiens (Human) - CCR6 gene Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988). Taurus_UMD|evm.model.AC_000166.1.603 O00270 GPR31_HUMAN 61.950 0.984026 0.981191 GPR31 - 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor - Homo sapiens (Human) - GPR31 gene High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE), with much lower affinities for other HETE isomers (PubMed:21712392, PubMed:29227475). 12-S-HETE is a eicosanoid, a 12-lipoxygenase (ALOX12) metabolite of arachidonic acid, involved in many physiologic and pathologic processes (PubMed:26965684, PubMed:28619714, PubMed:29227475). 12-S-HETE-binding leads to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B pathways leading to cell growth (PubMed:21712392, PubMed:29227475). Plays a crucial role for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells by mediating the translocation of KRAS from the endoplasmic reticulum to the plasma membrane (PM) and its association with the PM (PubMed:28619714). Contributes to enhanced immune responses by inducing dendrite protrusion of small intestinal CX3CR1(+) phagocytes for the uptake of luminal antigens (By similarity). Acts also as a key receptor for 12-(S)-HETE-mediated liver ischemia reperfusion injury (PubMed:29227475). Taurus_UMD|evm.model.AC_000166.1.604 Q569L8 CENPJ_MOUSE 59.843 0.278396 0.334077 Cenpj - Centromere protein J - Mus musculus (Mouse) - Cenpj gene Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (By similarity). Taurus_UMD|evm.model.AC_000166.1.605 Q9BWV7 TTLL2_HUMAN 70.321 0.937388 0.944257 TTLL2 - Probable tubulin polyglutamylase TTLL2 - Homo sapiens (Human) - TTLL2 gene Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity). Taurus_UMD|evm.model.AC_000166.1.606 A2VE54 UN93A_BOVIN 78.993 0.994778 0.838074 UNC93A - Protein unc-93 homolog A - Bos taurus (Bovine) - UNC93A gene Taurus_UMD|evm.model.AC_000166.1.613 P55196 AFAD_HUMAN 86.096 0.970474 0.984101 AFDN - Afadin - Homo sapiens (Human) - AFDN gene Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). Taurus_UMD|evm.model.AC_000166.1.614 Q9UIL4 KIF25_HUMAN 59.425 0.423659 1.89323 KIF25 - Kinesin-like protein KIF25 - Homo sapiens (Human) - KIF25 gene Minus-end microtubule-dependent motor protein (By similarity). Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase (PubMed:28263957). Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis (PubMed:28263957). May also act as a negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). Taurus_UMD|evm.model.AC_000166.1.615 Q8N878 FRMD1_HUMAN 54.647 0.996161 0.948998 FRMD1 - FERM domain-containing protein 1 - Homo sapiens (Human) - FRMD1 gene cytoplasmic side of apical plasma membrane, activating transcription factor binding, positive regulation of hippo signaling Taurus_UMD|evm.model.AC_000166.1.620 Q8R4A3 DACT1_MOUSE 75.000 0.0362319 1.24165 Dact1 - Dapper homolog 1 - Mus musculus (Mouse) - Dact1 gene Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB (By similarity). Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway. The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling (By similarity). May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines. Taurus_UMD|evm.model.AC_000166.1.624 Q9H3U7 SMOC2_HUMAN 70.574 0.931759 0.85426 SMOC2 - SPARC-related modular calcium-binding protein 2 precursor - Homo sapiens (Human) - SMOC2 gene Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis. Taurus_UMD|evm.model.AC_000166.1.629 O19110 TSPY1_BOVIN 74.359 0.612903 0.195584 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000166.1.632 Q95116 TSP2_BOVIN 99.573 0.902703 1.10684 THBS2 - Thrombospondin-2 precursor - Bos taurus (Bovine) - THBS2 gene Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties (By similarity). Taurus_UMD|evm.model.AC_000166.1.635 A2RRH5 WDR27_HUMAN 64.614 0.997462 0.952842 WDR27 - WD repeat-containing protein 27 - Homo sapiens (Human) - WDR27 gene nucleoplasm Taurus_UMD|evm.model.AC_000166.1.636 A2VDZ5 CF120_BOVIN 99.457 0.989189 1.00543 UPF0669 protein C6orf120 homolog precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000166.1.637 Q2T9V9 PHF10_BOVIN 100.000 0.904867 1.10244 PHF10 - PHD finger protein 10 - Bos taurus (Bovine) - PHF10 gene Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Taurus_UMD|evm.model.AC_000166.1.638 Q8IZS6 DYLT2_HUMAN 87.374 0.989744 0.984848 DYNLT2 - Dynein light chain Tctex-type protein 2 - Homo sapiens (Human) - DYNLT2 gene May be an accessory component of axonemal dynein and cytoplasmic dynein 1 (PubMed:11278908, PubMed:12584439). Candidate for involvement in male sterility (By similarity). Taurus_UMD|evm.model.AC_000166.1.639 Q5T6L9 EMARD_HUMAN 73.560 0.964337 1.03392 ERMARD - Endoplasmic reticulum membrane-associated RNA degradation protein - Homo sapiens (Human) - ERMARD gene May play a role in neuronal migration during embryonic development. Taurus_UMD|evm.model.AC_000166.1.646 P30205 WC11_BOVIN 85.470 0.234927 0.334958 Antigen WC1.1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000166.1.647 O00548 DLL1_HUMAN 89.227 0.997234 1 DLL1 - Delta-like protein 1 precursor - Homo sapiens (Human) - DLL1 gene Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:11006133). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (By similarity). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:11581320). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway. At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway. Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis. Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell. Plays a role in immune systeme development, namely the development of all T-cells and marginal zone (MZ) B-cells (By similarity). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (PubMed:11581320). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation. Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression. During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression. Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium. Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels. During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression. Controls sprouting angiogenesis and subsequent vertical branch formation througth regulation on tip cell differentiation. Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine. Plays a role during inner ear development; negatively regulates auditory hair cell differentiation. Plays a role during nephron development through Notch signaling pathway. Regulates growth, blood pressure and energy homeostasis (By similarity). Taurus_UMD|evm.model.AC_000166.1.649 A6QNT4 F120B_BOVIN 95.759 0.997268 1.04571 FAM120B - Constitutive coactivator of peroxisome proliferator-activated receptor gamma - Bos taurus (Bovine) - FAM120B gene Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity). Taurus_UMD|evm.model.AC_000166.1.651 Q2TBX6 PSB1_BOVIN 99.585 0.991736 1.00415 PSMB1 - Proteasome subunit beta type-1 precursor - Bos taurus (Bovine) - PSMB1 gene Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Taurus_UMD|evm.model.AC_000166.1.652 Q2HJ52 TBP_BOVIN 100.000 0.986395 0.460815 TBP - TATA-box-binding protein - Bos taurus (Bovine) - TBP gene General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Taurus_UMD|evm.model.AC_000166.1.653 P20226 TBP_HUMAN 96.732 0.863636 0.519174 TBP - TATA-box-binding protein - Homo sapiens (Human) - TBP gene General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071). Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription (PubMed:15970593). The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Taurus_UMD|evm.model.AC_000166.1.654 Q2YDC9 PDCD2_BOVIN 100.000 0.994203 1.00291 PDCD2 - Programmed cell death protein 2 - Bos taurus (Bovine) - PDCD2 gene May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000167.1.1 P04022 GAG_SRV1 36.530 0.397638 0.772036 gag - Gag polyprotein - Simian retrovirus SRV-1 - gag gene Matrix protein. Taurus_UMD|evm.model.AC_000167.1.4 Q9BQI4 CCDC3_HUMAN 49.697 0.875817 0.566667 CCDC3 - Coiled-coil domain-containing protein 3 precursor - Homo sapiens (Human) - CCDC3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (PubMed:25193116). Positively regulates lipid accumulation in adipose cells (By similarity). Taurus_UMD|evm.model.AC_000167.1.5 Q13136 LIPA1_HUMAN 70.241 0.993976 0.276206 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000167.1.6 Q13136 LIPA1_HUMAN 61.538 0.936916 0.356073 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000167.1.8 Q32L86 T126A_BOVIN 96.226 0.339806 1.56853 TMEM126A - Transmembrane protein 126A - Bos taurus (Bovine) - TMEM126A gene mitochondrion, mitochondrial respiratory chain complex I assembly Taurus_UMD|evm.model.AC_000167.1.9 P23508 CRCM_HUMAN 96.794 0.865385 1.12907 MCC - Colorectal mutant cancer protein - Homo sapiens (Human) - MCC gene Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). Taurus_UMD|evm.model.AC_000167.1.10 Q8IU60 DCP2_HUMAN 83.294 0.799591 1.16429 DCP2 - m7GpppN-mRNA hydrolase - Homo sapiens (Human) - DCP2 gene Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968, PubMed:28002401). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). Taurus_UMD|evm.model.AC_000167.1.11 Q29RM3 REEP5_BOVIN 99.145 0.859259 0.714286 REEP5 - Receptor expression-enhancing protein 5 - Bos taurus (Bovine) - REEP5 gene May enhance the cell surface expression of odorant receptors. Taurus_UMD|evm.model.AC_000167.1.12 Q3ZBG7 SRP19_BOVIN 100.000 0.986207 1.00694 SRP19 - Signal recognition particle 19 kDa protein - Bos taurus (Bovine) - SRP19 gene Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. Taurus_UMD|evm.model.AC_000167.1.13 P25054 APC_HUMAN 94.528 0.999299 1.00317 APC - Adenomatous polyposis coli protein - Homo sapiens (Human) - APC gene Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. Taurus_UMD|evm.model.AC_000167.1.15 Q9HCS5 E41LA_HUMAN 94.898 0.997089 1.00146 EPB41L4A - Band 4.1-like protein 4A - Homo sapiens (Human) - EPB41L4A gene cytoskeleton, actomyosin structure organization Taurus_UMD|evm.model.AC_000167.1.20 Q5NVD3 NREP_PONAB 82.353 0.650485 1.51471 NREP - Neuronal regeneration-related protein - Pongo abelii (Sumatran orangutan) - NREP gene May have roles in neural function and cellular differentiation. Ectopic expression promotes axonal regeneration, induces differentiation of fibroblast into myofibroblast, induces myofibroblast ameboid migration, augments motility of gliomas, and increases retinoic-acid regulation of lipid-droplet biogenesis. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation. Taurus_UMD|evm.model.AC_000167.1.21 Q5R746 YTDC2_PONAB 96.993 0.998601 1 YTHDC2 - 3'-5' RNA helicase YTHDC2 - Pongo abelii (Sumatran orangutan) - YTHDC2 gene 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis. Taurus_UMD|evm.model.AC_000167.1.24 Q8WVD3 RN138_HUMAN 58.772 0.980769 0.42449 RNF138 - E3 ubiquitin-protein ligase RNF138 - Homo sapiens (Human) - RNF138 gene E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285). Taurus_UMD|evm.model.AC_000167.1.25 O00370 LORF2_HUMAN 53.731 0.978022 0.214118 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000167.1.26 P58390 KCNN2_MOUSE 90.948 0.968288 0.563766 Kcnn2 - Small conductance calcium-activated potassium channel protein 2 - Mus musculus (Mouse) - Kcnn2 gene Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Taurus_UMD|evm.model.AC_000167.1.27 Q9H2S1 KCNN2_HUMAN 96.970 0.991379 0.400691 KCNN2 - Small conductance calcium-activated potassium channel protein 2 - Homo sapiens (Human) - KCNN2 gene Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Taurus_UMD|evm.model.AC_000167.1.28 P82916 RT17_BOVIN 99.231 0.984733 1.00769 MRPS17 - 28S ribosomal protein S17, mitochondrial - Bos taurus (Bovine) - MRPS17 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit Taurus_UMD|evm.model.AC_000167.1.29 P52301 RAN_XENLA 83.871 0.764706 0.550926 ran - GTP-binding nuclear protein Ran - Xenopus laevis (African clawed frog) - ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:8413630). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446). Required for normal progress through mitosis (By similarity). In concert with nemp1a/b, required for proper eye development (PubMed:25946333). Taurus_UMD|evm.model.AC_000167.1.30 P62828 RAN_RAT 72.043 0.8 0.532407 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Taurus_UMD|evm.model.AC_000167.1.31 Q2KIS1 RENBP_BOVIN 79.592 0.510638 0.217593 RENBP - N-acylglucosamine 2-epimerase - Bos taurus (Bovine) - RENBP gene Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). Taurus_UMD|evm.model.AC_000167.1.32 Q9NQ86 TRI36_HUMAN 94.787 0.99726 1.00275 TRIM36 - E3 ubiquitin-protein ligase TRIM36 - Homo sapiens (Human) - TRIM36 gene E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. Taurus_UMD|evm.model.AC_000167.1.33 Q5EAD5 PGTB1_BOVIN 83.896 0.994398 0.94695 PGGT1B - Geranylgeranyl transferase type-1 subunit beta - Bos taurus (Bovine) - PGGT1B gene Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B (By similarity). Taurus_UMD|evm.model.AC_000167.1.34 Q8NEF3 CC112_HUMAN 90.498 0.839695 1.17489 CCDC112 - Coiled-coil domain-containing protein 112 - Homo sapiens (Human) - CCDC112 gene Taurus_UMD|evm.model.AC_000167.1.35 P08760 KAD3_BOVIN 70.968 0.648936 0.414097 AK3 - GTP:AMP phosphotransferase AK3, mitochondrial - Bos taurus (Bovine) - AK3 gene Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. Taurus_UMD|evm.model.AC_000167.1.36 A7MB89 FEM1C_BOVIN 100.000 0.996764 1.00162 FEM1C - Protein fem-1 homolog C - Bos taurus (Bovine) - FEM1C gene Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Taurus_UMD|evm.model.AC_000167.1.37 Q9UMY4 SNX12_HUMAN 64.000 0.980198 0.623457 SNX12 - Sorting nexin-12 - Homo sapiens (Human) - SNX12 gene May be involved in several stages of intracellular trafficking. Taurus_UMD|evm.model.AC_000167.1.38 Q9Y2D4 EXC6B_HUMAN 77.966 0.430041 0.59926 EXOC6B - Exocyst complex component 6B - Homo sapiens (Human) - EXOC6B gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Taurus_UMD|evm.model.AC_000167.1.39 Q2LGB7 TCAM2_BOVIN 100.000 0.991416 1.00431 TICAM2 - TIR domain-containing adapter molecule 2 - Bos taurus (Bovine) - TICAM2 gene Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response. Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria. Taurus_UMD|evm.model.AC_000167.1.41 Q9Y3B3 TMED7_HUMAN 96.444 0.99115 1.00893 TMED7 - Transmembrane emp24 domain-containing protein 7 precursor - Homo sapiens (Human) - TMED7 gene Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications. Taurus_UMD|evm.model.AC_000167.1.42 Q3SZU4 CDO1_BOVIN 100.000 0.984496 0.645 CDO1 - Cysteine dioxygenase type 1 - Bos taurus (Bovine) - CDO1 gene cysteine dioxygenase activity, ferrous iron binding, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, L-cysteine catabolic process Taurus_UMD|evm.model.AC_000167.1.43 Q3SZU4 CDO1_BOVIN 100.000 0.736842 0.38 CDO1 - Cysteine dioxygenase type 1 - Bos taurus (Bovine) - CDO1 gene cysteine dioxygenase activity, ferrous iron binding, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, L-cysteine catabolic process Taurus_UMD|evm.model.AC_000167.1.44 Q9CQY1 ATG12_MOUSE 73.333 0.860759 0.560284 Atg12 - Ubiquitin-like protein ATG12 - Mus musculus (Mouse) - Atg12 gene Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Taurus_UMD|evm.model.AC_000167.1.45 Q9DCR2 AP3S1_MOUSE 100.000 0.801587 0.65285 Ap3s1 - AP-3 complex subunit sigma-1 - Mus musculus (Mouse) - Ap3s1 gene Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Taurus_UMD|evm.model.AC_000167.1.46 A0A6J2ATK2 AMPQ_ACIJB 77.117 0.99787 0.946573 LVRN - Aminopeptidase Q - Acinonyx jubatus (Cheetah) - LVRN gene Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface (By similarity). Involved in coat pigmentation patterns. During skin development, may be required to establish the periodicity of tabby markings, initiating a pre-pattern at or before hair follicle development (PubMed:22997338). Taurus_UMD|evm.model.AC_000167.1.47 Q3UKZ7 A14EL_MOUSE 83.553 0.986842 1 Arl14epl - ARL14 effector protein-like - Mus musculus (Mouse) - Arl14epl gene Taurus_UMD|evm.model.AC_000167.1.48 Q3T044 P33MX_BOVIN 100.000 0.993464 1.00328 P33MONOX - Putative monooxygenase p33MONOX - Bos taurus (Bovine) - P33MONOX gene Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth (By similarity). Taurus_UMD|evm.model.AC_000167.1.49 F1LWT0 SIMC1_RAT 74.962 0.656762 0.770932 Simc1 - SUMO-interacting motif-containing protein 1 - Rattus norvegicus (Rat) - Simc1 gene Inhibits the protease activity of CAPN3. Taurus_UMD|evm.model.AC_000167.1.50 Q5RDY9 F151A_PONAB 68.182 0.631068 0.176068 FAM151A - Protein FAM151A - Pongo abelii (Sumatran orangutan) - FAM151A gene Taurus_UMD|evm.model.AC_000167.1.51 Q8WW52 F151A_HUMAN 69.748 0.95935 0.210256 FAM151A - Protein FAM151A - Homo sapiens (Human) - FAM151A gene extracellular exosome, membrane Taurus_UMD|evm.model.AC_000167.1.52 Q8WW52 F151A_HUMAN 57.273 0.989529 0.326496 FAM151A - Protein FAM151A - Homo sapiens (Human) - FAM151A gene extracellular exosome, membrane Taurus_UMD|evm.model.AC_000167.1.53 Q29RH4 THOC3_BOVIN 82.022 0.994152 0.974359 THOC3 - THO complex subunit 3 - Bos taurus (Bovine) - THOC3 gene Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity). Taurus_UMD|evm.model.AC_000167.1.54 P84087 CPLX2_RAT 100.000 0.985185 1.00746 Cplx2 - Complexin-2 - Rattus norvegicus (Rat) - Cplx2 gene Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (PubMed:15870114). Taurus_UMD|evm.model.AC_000167.1.55 P17124 HRH2_CANLF 82.730 0.852381 1.16992 HRH2 - Histamine H2 receptor - Canis lupus familiaris (Dog) - HRH2 gene The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Taurus_UMD|evm.model.AC_000167.1.57 Q5E9M8 SFXN1_BOVIN 100.000 0.993808 1.00311 SFXN1 - Sideroflexin-1 - Bos taurus (Bovine) - SFXN1 gene Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D-serine and L-serine. Also able to transport other amino-acids, such as alanine (By similarity). May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity). Taurus_UMD|evm.model.AC_000167.1.58 Q95136 DRD1_BOVIN 100.000 0.995526 1.00224 DRD1 - D(1A) dopamine receptor - Bos taurus (Bovine) - DRD1 gene Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Taurus_UMD|evm.model.AC_000167.1.59 Q9CR47 NSA2_MOUSE 55.556 0.984127 0.242308 Nsa2 - Ribosome biogenesis protein NSA2 homolog - Mus musculus (Mouse) - Nsa2 gene Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). Taurus_UMD|evm.model.AC_000167.1.60 Q9CR47 NSA2_MOUSE 77.049 0.731707 0.315385 Nsa2 - Ribosome biogenesis protein NSA2 homolog - Mus musculus (Mouse) - Nsa2 gene Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). Taurus_UMD|evm.model.AC_000167.1.61 O08585 CLCA_MOUSE 66.265 0.719101 0.378723 Clta - Clathrin light chain A - Mus musculus (Mouse) - Clta gene Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (By similarity). Taurus_UMD|evm.model.AC_000167.1.62 Q9P109 GCNT4_HUMAN 87.665 0.995604 1.00442 GCNT4 - Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 - Homo sapiens (Human) - GCNT4 gene Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O-glycan or I-branching enzyme activity. Taurus_UMD|evm.model.AC_000167.1.63 Q8N7Z5 ANR31_HUMAN 63.001 0.9637 1.07368 ANKRD31 - Ankyrin repeat domain-containing protein 31 - Homo sapiens (Human) - ANKRD31 gene Required for DNA double-strand breaks (DSBs) formation during meiotic recombination. Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation. Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes. Taurus_UMD|evm.model.AC_000167.1.64 O02751 CFDP2_BOVIN 73.077 0.934783 0.233108 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000167.1.66 A7Z064 HMDH_BOVIN 100.000 0.99775 1.00113 HMGCR - 3-hydroxy-3-methylglutaryl-coenzyme A reductase - Bos taurus (Bovine) - HMGCR gene Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. Taurus_UMD|evm.model.AC_000167.1.67 Q9GKI7 CERT_BOVIN 100.000 0.9968 1.0016 CERT1 - Ceramide transfer protein - Bos taurus (Bovine) - CERT1 gene Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. Taurus_UMD|evm.model.AC_000167.1.68 Q9UBT6 POLK_HUMAN 83.601 0.98861 1.0092 POLK - DNA polymerase kappa - Homo sapiens (Human) - POLK gene DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Taurus_UMD|evm.model.AC_000167.1.69 A6NHY2 AKD1B_HUMAN 59.322 0.335404 0.304924 ANKDD1B - Ankyrin repeat and death domain-containing protein 1B - Homo sapiens (Human) - ANKDD1B gene Taurus_UMD|evm.model.AC_000167.1.70 Q8NA72 POC5_HUMAN 79.690 0.996534 1.00348 POC5 - Centrosomal protein POC5 - Homo sapiens (Human) - POC5 gene Essential for the assembly of the distal half of centrioles, required for centriole elongation. Taurus_UMD|evm.model.AC_000167.1.71 Q496J9 SV2C_HUMAN 87.749 0.66004 0.691884 SV2C - Synaptic vesicle glycoprotein 2C - Homo sapiens (Human) - SV2C gene Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. Taurus_UMD|evm.model.AC_000167.1.72 Q69ZS6 SV2C_MOUSE 89.598 0.972222 0.594223 Sv2c - Synaptic vesicle glycoprotein 2C - Mus musculus (Mouse) - Sv2c gene Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. Taurus_UMD|evm.model.AC_000167.1.73 Q13576 IQGA2_HUMAN 89.651 0.998731 1.00063 IQGAP2 - Ras GTPase-activating-like protein IQGAP2 - Homo sapiens (Human) - IQGAP2 gene Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. Taurus_UMD|evm.model.AC_000167.1.74 A7YY44 PAR1_BOVIN 99.766 0.995327 1.00234 F2R - Proteinase-activated receptor 1 precursor - Bos taurus (Bovine) - F2R gene High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. Taurus_UMD|evm.model.AC_000167.1.75 Q2HJA4 PAR2_BOVIN 99.747 0.994949 1.00253 F2RL1 - Proteinase-activated receptor 2 precursor - Bos taurus (Bovine) - F2RL1 gene Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Taurus_UMD|evm.model.AC_000167.1.76 Q8WXG8 S100Z_HUMAN 85.859 0.98 1.0101 S100Z - Protein S100-Z - Homo sapiens (Human) - S100Z gene calcium ion binding, calcium-dependent protein binding, protein homodimerization activity Taurus_UMD|evm.model.AC_000167.1.77 Q28557 CRHBP_SHEEP 96.296 0.993846 1.00309 CRHBP - Corticotropin-releasing factor-binding protein precursor - Ovis aries (Sheep) - CRHBP gene Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Taurus_UMD|evm.model.AC_000167.1.78 Q8N302 AGGF1_HUMAN 88.167 0.967742 0.998599 AGGF1 - Angiogenic factor with G patch and FHA domains 1 - Homo sapiens (Human) - AGGF1 gene Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. Taurus_UMD|evm.model.AC_000167.1.79 Q96IU2 ZBED3_HUMAN 72.996 0.990698 0.918803 ZBED3 - Zinc finger BED domain-containing protein 3 - Homo sapiens (Human) - ZBED3 gene Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin (By similarity). Involved in transcription activation of Wnt target gene expression (By similarity). Plays a role in symmetric division of blastomeres in the early stages of embryogenesis via regulation of mitotic spindle central positioning and organization of the F-actin filament network (By similarity). Plays a role in regulating the distribution of cellular organelles, via modulation of cytoskeletal dynamics and cytoplasmic lattice formation (By similarity). Taurus_UMD|evm.model.AC_000167.1.81 O95263 PDE8B_HUMAN 90.686 0.987772 0.831638 PDE8B - High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B - Homo sapiens (Human) - PDE8B gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. Taurus_UMD|evm.model.AC_000167.1.82 Q9HAD4 WDR41_HUMAN 86.492 0.995595 0.989107 WDR41 - WD repeat-containing protein 41 - Homo sapiens (Human) - WDR41 gene Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292). Taurus_UMD|evm.model.AC_000167.1.83 O09113 OTP_MOUSE 100.000 0.978947 0.292308 Otp - Homeobox protein orthopedia - Mus musculus (Mouse) - Otp gene Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. Taurus_UMD|evm.model.AC_000167.1.84 O09113 OTP_MOUSE 100.000 0.814208 0.563077 Otp - Homeobox protein orthopedia - Mus musculus (Mouse) - Otp gene Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group. Taurus_UMD|evm.model.AC_000167.1.85 P48427 TBCA_BOVIN 100.000 0.981651 1.00926 TBCA - Tubulin-specific chaperone A - Bos taurus (Bovine) - TBCA gene Tubulin-folding protein; involved in the early step of the tubulin folding pathway. Taurus_UMD|evm.model.AC_000167.1.86 P54252 ATX3_HUMAN 95.817 0.952727 0.761773 ATXN3 - Ataxin-3 - Homo sapiens (Human) - ATXN3 gene Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). Taurus_UMD|evm.model.AC_000167.1.88 Q32PG1 AP3B1_BOVIN 100.000 0.998157 1.00092 AP3B1 - AP-3 complex subunit beta-1 - Bos taurus (Bovine) - AP3B1 gene Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Taurus_UMD|evm.model.AC_000167.1.89 O77735 SCAM1_PIG 84.179 0.931148 0.902367 SCAMP1 - Secretory carrier-associated membrane protein 1 - Sus scrofa (Pig) - SCAMP1 gene Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. Taurus_UMD|evm.model.AC_000167.1.90 Q6ZUX7 LHPL2_HUMAN 93.860 0.991266 1.00439 LHFPL2 - LHFPL tetraspan subfamily member 2 protein - Homo sapiens (Human) - LHFPL2 gene Plays a role in female and male fertility. Involved in distal reproductive tract development. Taurus_UMD|evm.model.AC_000167.1.93 P15848 ARSB_HUMAN 89.306 0.996255 1.00188 ARSB - Arylsulfatase B precursor - Homo sapiens (Human) - ARSB gene Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Taurus_UMD|evm.model.AC_000167.1.94 Q9UI17 M2GD_HUMAN 90.581 0.985899 0.982679 DMGDH - Dimethylglycine dehydrogenase, mitochondrial precursor - Homo sapiens (Human) - DMGDH gene Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro. Taurus_UMD|evm.model.AC_000167.1.95 Q9H2M3 BHMT2_HUMAN 80.952 0.75576 1.19559 BHMT2 - S-methylmethionine--homocysteine S-methyltransferase BHMT2 - Homo sapiens (Human) - BHMT2 gene Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. Taurus_UMD|evm.model.AC_000167.1.96 Q5I597 BHMT1_BOVIN 100.000 0.753247 1.32432 BHMT - Betaine--homocysteine S-methyltransferase 1 - Bos taurus (Bovine) - BHMT gene Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). Taurus_UMD|evm.model.AC_000167.1.97 Q8N9B5 JMY_HUMAN 88.004 0.997984 1.00405 JMY - Junction-mediating and -regulatory protein - Homo sapiens (Human) - JMY gene Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). Taurus_UMD|evm.model.AC_000167.1.98 Q2KJ56 HOME1_BOVIN 100.000 0.9 1.10169 HOMER1 - Homer protein homolog 1 - Bos taurus (Bovine) - HOMER1 gene Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity). Taurus_UMD|evm.model.AC_000167.1.99 Q2HJ44 GLD2_BOVIN 100.000 0.995876 1.00207 TENT2 - Poly(A) RNA polymerase GLD2 - Bos taurus (Bovine) - TENT2 gene Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation. Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs. Taurus_UMD|evm.model.AC_000167.1.100 Q8N3K9 CMYA5_HUMAN 81.929 0.345951 0.980339 CMYA5 - Cardiomyopathy-associated protein 5 - Homo sapiens (Human) - CMYA5 gene May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). Taurus_UMD|evm.model.AC_000167.1.102 Q5HYI7 MTX3_HUMAN 94.872 0.99361 1.00321 MTX3 - Metaxin-3 - Homo sapiens (Human) - MTX3 gene Could function in transport of proteins into the mitochondrion. Taurus_UMD|evm.model.AC_000167.1.103 Q3SWW8 TSP4_BOVIN 100.000 0.997921 1.00104 THBS4 - Thrombospondin-4 precursor - Bos taurus (Bovine) - THBS4 gene Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000167.1.104 Q4R6L9 SERC5_MACFA 86.557 0.919565 1.08491 SERINC5 - Serine incorporator 5 - Macaca fascicularis (Crab-eating macaque) - SERINC5 gene Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity). Taurus_UMD|evm.model.AC_000167.1.105 Q5RAL9 GNA1_PONAB 99.457 0.989189 1.00543 GNPNAT1 - Glucosamine 6-phosphate N-acetyltransferase - Pongo abelii (Sumatran orangutan) - GNPNAT1 gene Taurus_UMD|evm.model.AC_000167.1.106 Q5RDP3 STYX_PONAB 97.758 0.991071 1.00448 STYX - Serine/threonine/tyrosine-interacting protein - Pongo abelii (Sumatran orangutan) - STYX gene Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (By similarity). Plays a role in spermatogenesis (By similarity). Taurus_UMD|evm.model.AC_000167.1.107 P62334 PRS10_MOUSE 100.000 0.960396 1.03856 Psmc6 - 26S proteasome regulatory subunit 10B - Mus musculus (Mouse) - Psmc6 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Taurus_UMD|evm.model.AC_000167.1.108 A5PJN2 ERO1A_BOVIN 100.000 0.995736 1.00214 ERO1A - ERO1-like protein alpha precursor - Bos taurus (Bovine) - ERO1A gene Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1 (By similarity). Taurus_UMD|evm.model.AC_000167.1.109 Q8N3F9 G137C_HUMAN 94.326 0.498221 0.655012 GPR137C - Integral membrane protein GPR137C - Homo sapiens (Human) - GPR137C gene Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. Taurus_UMD|evm.model.AC_000167.1.110 Q9P2K2 TXD16_HUMAN 74.817 0.993703 0.962424 TXNDC16 - Thioredoxin domain-containing protein 16 precursor - Homo sapiens (Human) - TXNDC16 gene endoplasmic reticulum lumen, extracellular exosome Taurus_UMD|evm.model.AC_000167.1.111 P43116 PE2R2_HUMAN 83.520 0.994334 0.986034 PTGER2 - Prostaglandin E2 receptor EP2 subtype - Homo sapiens (Human) - PTGER2 gene Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle. Taurus_UMD|evm.model.AC_000167.1.112 Q8MJJ1 SPG21_BOVIN 100.000 0.993528 1.00325 SPG21 - Maspardin - Bos taurus (Bovine) - SPG21 gene May play a role as a negative regulatory factor in CD4-dependent T-cell activation. Taurus_UMD|evm.model.AC_000167.1.113 O77480 FMT_BOVIN 100.000 0.994885 1.00256 MTFMT - Methionyl-tRNA formyltransferase, mitochondrial precursor - Bos taurus (Bovine) - MTFMT gene Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism. Taurus_UMD|evm.model.AC_000167.1.114 A0JNM1 OSTB_BOVIN 100.000 0.984733 1.00769 SLC51B - Organic solute transporter subunit beta - Bos taurus (Bovine) - SLC51B gene Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities (By similarity). Taurus_UMD|evm.model.AC_000167.1.115 Q08E00 RASLC_BOVIN 99.624 0.992509 1.00376 RASL12 - Ras-like protein family member 12 - Bos taurus (Bovine) - RASL12 gene plasma membrane, GDP binding, GTP binding, GTPase activity Taurus_UMD|evm.model.AC_000167.1.116 C9JR72 KBTBD_HUMAN 89.520 0.995643 1.00218 KBTBD13 - Kelch repeat and BTB domain-containing protein 13 - Homo sapiens (Human) - KBTBD13 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000167.1.117 F5GYI3 UBA1L_HUMAN 72.019 0.99511 1.07349 UBAP1L - Ubiquitin-associated protein 1-like - Homo sapiens (Human) - UBAP1L gene ESCRT I complex, ubiquitin binding, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Taurus_UMD|evm.model.AC_000167.1.118 Q8N8D1 PDCD7_HUMAN 90.779 0.905028 1.10722 PDCD7 - Programmed cell death protein 7 - Homo sapiens (Human) - PDCD7 gene Promotes apoptosis when overexpressed. Taurus_UMD|evm.model.AC_000167.1.119 Q3ZC82 ZC3HE_BOVIN 89.552 0.891892 0.10068 ZC3H14 - Zinc finger CCCH domain-containing protein 14 - Bos taurus (Bovine) - ZC3H14 gene Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides. Taurus_UMD|evm.model.AC_000167.1.120 O76031 CLPX_HUMAN 98.353 0.743558 1.28752 CLPX - ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor - Homo sapiens (Human) - CLPX gene ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP (PubMed:28874591). Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis (PubMed:28874591). Important for efficient erythropoiesis through upregulation of heme biosynthesis (PubMed:25957689, PubMed:28874591). Taurus_UMD|evm.model.AC_000167.1.121 O19112 CILP1_PIG 95.627 0.366559 1.5576 CILP - Cartilage intermediate layer protein 1 - Sus scrofa (Pig) - CILP gene Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage (By similarity). Taurus_UMD|evm.model.AC_000167.1.122 Q8N5Y8 PAR16_HUMAN 92.547 0.993808 1.00311 PARP16 - Protein mono-ADP-ribosyltransferase PARP16 - Homo sapiens (Human) - PARP16 gene Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565, PubMed:25043379). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565). Taurus_UMD|evm.model.AC_000167.1.123 Q8IVU1 IGDC3_HUMAN 84.211 0.897695 0.85258 IGDCC3 - Immunoglobulin superfamily DCC subclass member 3 precursor - Homo sapiens (Human) - IGDCC3 gene Taurus_UMD|evm.model.AC_000167.1.124 Q8TDY8 IGDC4_HUMAN 89.209 0.997606 1.0024 IGDCC4 - Immunoglobulin superfamily DCC subclass member 4 precursor - Homo sapiens (Human) - IGDCC4 gene Taurus_UMD|evm.model.AC_000167.1.125 Q6V1X1 DPP8_HUMAN 98.107 0.997775 1.00111 DPP8 - Dipeptidyl peptidase 8 - Homo sapiens (Human) - DPP8 gene Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396) (Probable). Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism (PubMed:27820798, PubMed:29967349, PubMed:32796818). Taurus_UMD|evm.model.AC_000167.1.126 A7YY55 HACD3_BOVIN 100.000 0.99449 1.00276 HACD3 - Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 - Bos taurus (Bovine) - HACD3 gene Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (By similarity). Taurus_UMD|evm.model.AC_000167.1.127 Q5EA76 INT14_BOVIN 100.000 0.996146 1.00193 INTS14 - Integrator complex subunit 14 - Bos taurus (Bovine) - INTS14 gene Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. Taurus_UMD|evm.model.AC_000167.1.128 Q28139 NCKX1_BOVIN 99.836 0.998357 1.00082 SLC24A1 - Sodium/potassium/calcium exchanger 1 - Bos taurus (Bovine) - SLC24A1 gene Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity). Taurus_UMD|evm.model.AC_000167.1.129 Q7Z401 MYCPP_HUMAN 91.252 0.998952 1.02415 DENND4A - C-myc promoter-binding protein - Homo sapiens (Human) - DENND4A gene Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. Taurus_UMD|evm.model.AC_000167.1.131 P62494 RB11A_RAT 100.000 0.990783 1.00463 Rab11a - Ras-related protein Rab-11A precursor - Rattus norvegicus (Rat) - Rab11a gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). The small Rab GTPase RAB11A regulates endocytic recycling (PubMed:11163216). Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Taurus_UMD|evm.model.AC_000167.1.132 Q80T91 MEG11_MOUSE 80.538 0.912377 0.836847 Megf11 - Multiple epidermal growth factor-like domains protein 11 precursor - Mus musculus (Mouse) - Megf11 gene May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. Taurus_UMD|evm.model.AC_000167.1.133 A6BM72 MEG11_HUMAN 91.089 0.671141 0.14272 MEGF11 - Multiple epidermal growth factor-like domains protein 11 precursor - Homo sapiens (Human) - MEGF11 gene May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity). Taurus_UMD|evm.model.AC_000167.1.134 A0JN80 DI3L1_BOVIN 99.905 0.998102 1.00095 DIS3L - DIS3-like exonuclease 1 - Bos taurus (Bovine) - DIS3L gene Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. Taurus_UMD|evm.model.AC_000167.1.135 Q3ZCC4 TIPIN_BOVIN 100.000 0.83046 1.2 TIPIN - TIMELESS-interacting protein - Bos taurus (Bovine) - TIPIN gene Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (By similarity). Taurus_UMD|evm.model.AC_000167.1.136 Q02750 MP2K1_HUMAN 100.000 0.994924 1.00254 MAP2K1 - Dual specificity mitogen-activated protein kinase kinase 1 - Homo sapiens (Human) - MAP2K1 gene Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. Taurus_UMD|evm.model.AC_000167.1.137 Q29S17 SNPC5_BOVIN 100.000 0.979798 1.0102 SNAPC5 - snRNA-activating protein complex subunit 5 - Bos taurus (Bovine) - SNAPC5 gene Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity). Taurus_UMD|evm.model.AC_000167.1.138 Q58DW0 RL4_BOVIN 100.000 0.995272 1.00237 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Taurus_UMD|evm.model.AC_000167.1.139 A6QM04 ZWILC_BOVIN 100.000 0.99661 1.0017 ZWILCH - Protein zwilch homolog - Bos taurus (Bovine) - ZWILCH gene Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity). Taurus_UMD|evm.model.AC_000167.1.140 Q6UWM7 LCTL_HUMAN 87.125 0.996479 1.00176 LCTL - Lactase-like protein precursor - Homo sapiens (Human) - LCTL gene Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Taurus_UMD|evm.model.AC_000167.1.142 O43541 SMAD6_HUMAN 95.573 0.995984 1.00403 SMAD6 - Mothers against decapentaplegic homolog 6 - Homo sapiens (Human) - SMAD6 gene Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta (PubMed:9436979, PubMed:16951688, PubMed:22275001, PubMed:9759503, PubMed:10647776, PubMed:10708948, PubMed:10708949, PubMed:30848080). Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes (PubMed:16951688). Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding (PubMed:9436979, PubMed:30848080). Binds to regulatory elements in target promoter regions (PubMed:16491121). Taurus_UMD|evm.model.AC_000167.1.144 Q53H47 SETMR_HUMAN 57.895 0.942857 0.204678 SETMAR - Histone-lysine N-methyltransferase SETMAR - Homo sapiens (Human) - SETMAR gene Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750). Taurus_UMD|evm.model.AC_000167.1.145 P84025 SMAD3_RAT 99.765 0.995305 1.00235 Smad3 - Mothers against decapentaplegic homolog 3 - Rattus norvegicus (Rat) - Smad3 gene Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). Taurus_UMD|evm.model.AC_000167.1.147 Q5RET3 AAGAB_PONAB 90.794 0.993671 1.00317 AAGAB - Alpha- and gamma-adaptin-binding protein p34 - Pongo abelii (Sumatran orangutan) - AAGAB gene May be involved in endocytic recycling of growth factor receptors such as EGFR. Taurus_UMD|evm.model.AC_000167.1.148 Q86VS3 IQCH_HUMAN 76.254 0.997164 1.03019 IQCH - IQ domain-containing protein H - Homo sapiens (Human) - IQCH gene May play a regulatory role in spermatogenesis. Taurus_UMD|evm.model.AC_000167.1.149 Q0VG49 CO061_MOUSE 94.904 0.987342 1.00637 Uncharacterized protein C15orf61 homolog precursor - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000167.1.150 Q13163 MP2K5_HUMAN 74.924 0.991968 0.555804 MAP2K5 - Dual specificity mitogen-activated protein kinase kinase 5 - Homo sapiens (Human) - MAP2K5 gene Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. Taurus_UMD|evm.model.AC_000167.1.151 Q8BX46 SKOR1_MOUSE 92.159 0.997847 0.963693 Skor1 - SKI family transcriptional corepressor 1 - Mus musculus (Mouse) - Skor1 gene Inhibits BMP signaling (By similarity). Acts as a transcriptional corepressor of LBX1. Taurus_UMD|evm.model.AC_000167.1.152 A8D8X1 RL10_SHEEP 75.000 0.887755 0.457944 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000167.1.153 O75925 PIAS1_HUMAN 99.078 0.996933 1.00154 PIAS1 - E3 SUMO-protein ligase PIAS1 - Homo sapiens (Human) - PIAS1 gene Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Taurus_UMD|evm.model.AC_000167.1.154 Q3T0E8 CALL4_BOVIN 99.346 0.883721 1.12418 CALML4 - Calmodulin-like protein 4 - Bos taurus (Bovine) - CALML4 gene calcium ion binding, enzyme regulator activity Taurus_UMD|evm.model.AC_000167.1.155 Q5JZQ8 CLN6_CANLF 93.891 0.990385 1 CLN6 - Ceroid-lipofuscinosis neuronal protein 6 homolog - Canis lupus familiaris (Dog) - CLN6 gene early endosome, endoplasmic reticulum, endoplasmic reticulum lumen, membrane raft, lysophosphatidic acid binding, protein homodimerization activity, sulfatide binding, cholesterol metabolic process, ganglioside metabolic process, glycosaminoglycan metabolic process Taurus_UMD|evm.model.AC_000167.1.157 Q9UK73 FEM1B_HUMAN 99.522 0.996815 1.00159 FEM1B - Protein fem-1 homolog B - Homo sapiens (Human) - FEM1B gene Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1. Taurus_UMD|evm.model.AC_000167.1.158 Q9UKX5 ITA11_HUMAN 92.593 0.998318 1.00084 ITGA11 - Integrin alpha-11 precursor - Homo sapiens (Human) - ITGA11 gene Integrin alpha-11/beta-1 is a receptor for collagen. Taurus_UMD|evm.model.AC_000167.1.159 Q9UQ03 COR2B_HUMAN 97.534 0.969499 0.95625 CORO2B - Coronin-2B - Homo sapiens (Human) - CORO2B gene May play a role in the reorganization of neuronal actin structure. Taurus_UMD|evm.model.AC_000167.1.160 P51122 AN32A_BOVIN 100.000 0.992 1.00402 ANP32A - Acidic leucine-rich nuclear phosphoprotein 32 family member A - Bos taurus (Bovine) - ANP32A gene Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition. Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A. Taurus_UMD|evm.model.AC_000167.1.161 Q32KL7 SPESP_BOVIN 100.000 0.986486 1.01093 SPESP1 - Sperm equatorial segment protein 1 precursor - Bos taurus (Bovine) - SPESP1 gene Involved in fertilization ability of sperm. Taurus_UMD|evm.model.AC_000167.1.162 Q96PH1 NOX5_HUMAN 81.590 0.286058 1.08758 NOX5 - NADPH oxidase 5 - Homo sapiens (Human) - NOX5 gene Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. Taurus_UMD|evm.model.AC_000167.1.163 O18756 GLCE_BOVIN 100.000 0.9625 1.03728 GLCE - D-glucuronyl C5-epimerase - Bos taurus (Bovine) - GLCE gene Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. Taurus_UMD|evm.model.AC_000167.1.165 Q9NXK6 PAQR5_HUMAN 83.333 0.993958 1.00303 PAQR5 - Membrane progestin receptor gamma - Homo sapiens (Human) - PAQR5 gene Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167). Taurus_UMD|evm.model.AC_000167.1.166 Q02241 KIF23_HUMAN 93.222 0.996849 0.991667 KIF23 - Kinesin-like protein KIF23 - Homo sapiens (Human) - KIF23 gene Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. Taurus_UMD|evm.model.AC_000167.1.167 P05386 RLA1_HUMAN 100.000 0.982609 1.00877 RPLP1 - 60S acidic ribosomal protein P1 - Homo sapiens (Human) - RPLP1 gene Plays an important role in the elongation step of protein synthesis. Taurus_UMD|evm.model.AC_000167.1.168 Q04726 TLE3_HUMAN 99.093 0.997403 0.997409 TLE3 - Transducin-like enhancer protein 3 - Homo sapiens (Human) - TLE3 gene Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). Taurus_UMD|evm.model.AC_000167.1.170 Q8HYY4 UACA_BOVIN 99.427 0.983769 1.01142 UACA - Uveal autoantigen with coiled-coil domains and ankyrin repeats protein - Bos taurus (Bovine) - UACA gene Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). Taurus_UMD|evm.model.AC_000167.1.171 Q9BRS8 LARP6_HUMAN 93.192 0.965909 0.89613 LARP6 - La-related protein 6 - Homo sapiens (Human) - LARP6 gene Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. Taurus_UMD|evm.model.AC_000167.1.172 Q5NVM3 THA10_PONAB 63.636 0.550562 0.674242 THAP10 - THAP domain-containing protein 10 - Pongo abelii (Sumatran orangutan) - THAP10 gene Taurus_UMD|evm.model.AC_000167.1.173 Q8IUZ0 LRC49_HUMAN 87.463 0.888291 1.08309 LRRC49 - Leucine-rich repeat-containing protein 49 - Homo sapiens (Human) - LRRC49 gene cytoplasm, outer dynein arm assembly Taurus_UMD|evm.model.AC_000167.1.174 Q3UTY6 THSD4_MOUSE 81.534 0.883838 0.388998 Thsd4 - Thrombospondin type-1 domain-containing protein 4 precursor - Mus musculus (Mouse) - Thsd4 gene Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN. Taurus_UMD|evm.model.AC_000167.1.175 Q6ZMP0 THSD4_HUMAN 93.849 0.96789 0.642436 THSD4 - Thrombospondin type-1 domain-containing protein 4 precursor - Homo sapiens (Human) - THSD4 gene Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity). Taurus_UMD|evm.model.AC_000167.1.176 Q9TTF0 NR2E3_BOVIN 99.757 0.995146 1.00243 NR2E3 - Photoreceptor-specific nuclear receptor - Bos taurus (Bovine) - NR2E3 gene Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. Taurus_UMD|evm.model.AC_000167.1.177 B2RTY4 MYO9A_HUMAN 89.963 0.115071 0.91405 MYO9A - Unconventional myosin-IXa - Homo sapiens (Human) - MYO9A gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). Taurus_UMD|evm.model.AC_000167.1.178 Q96LD8 SENP8_HUMAN 91.469 0.985915 1.00472 SENP8 - Sentrin-specific protease 8 - Homo sapiens (Human) - SENP8 gene Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. Taurus_UMD|evm.model.AC_000167.1.179 Q3V3G7 GRM2A_MOUSE 77.199 0.672606 1.40312 Gramd2a - GRAM domain-containing protein 2A - Mus musculus (Mouse) - Gramd2a gene Participates in the organization ofendoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE). Taurus_UMD|evm.model.AC_000167.1.180 P14618 KPYM_HUMAN 97.552 0.996241 1.00188 PKM - Pyruvate kinase PKM - Homo sapiens (Human) - PKM gene Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723). In addition to its role in glycolysis, also regulates transcription (PubMed:18191611, PubMed:21620138). Stimulates POU5F1-mediated transcriptional activation (PubMed:18191611). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). Also acts as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a general role in caspase independent cell death of tumor cells (PubMed:17308100). Taurus_UMD|evm.model.AC_000167.1.181 Q2NL67 PARP6_HUMAN 91.988 0.936416 1.09841 PARP6 - Protein mono-ADP-ribosyltransferase PARP6 - Homo sapiens (Human) - PARP6 gene Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Taurus_UMD|evm.model.AC_000167.1.182 Q96J87 CELF6_HUMAN 98.129 0.995842 1 CELF6 - CUGBP Elav-like family member 6 - Homo sapiens (Human) - CELF6 gene RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA. Taurus_UMD|evm.model.AC_000167.1.184 Q0V8R6 HEXA_BOVIN 100.000 0.996226 1.00189 HEXA - Beta-hexosaminidase subunit alpha precursor - Bos taurus (Bovine) - HEXA gene Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. Taurus_UMD|evm.model.AC_000167.1.185 A6NGA9 TM202_HUMAN 68.675 0.921053 0.974359 TMEM202 - Transmembrane protein 202 - Homo sapiens (Human) - TMEM202 gene plasma membrane Taurus_UMD|evm.model.AC_000167.1.186 A6NGA9 TM202_HUMAN 41.833 0.884058 1.01099 TMEM202 - Transmembrane protein 202 - Homo sapiens (Human) - TMEM202 gene plasma membrane Taurus_UMD|evm.model.AC_000167.1.187 A2VEA3 ARI1_BOVIN 100.000 0.996403 1.0018 ARIH1 - E3 ubiquitin-protein ligase ARIH1 - Bos taurus (Bovine) - ARIH1 gene E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes. Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear. According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest. According to another report EIF4E2 ubiquitination leads to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2. In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, may act in nuclear subcellular localization and nuclear morphology. Taurus_UMD|evm.model.AC_000167.1.189 Q1JQ97 BBS4_BOVIN 100.000 0.996154 1.00193 BBS4 - Bardet-Biedl syndrome 4 protein homolog - Bos taurus (Bovine) - BBS4 gene May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane (By similarity). Taurus_UMD|evm.model.AC_000167.1.190 A2VE47 ADPGK_BOVIN 100.000 0.995984 1.00201 ADPGK - ADP-dependent glucokinase precursor - Bos taurus (Bovine) - ADPGK gene Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity). Taurus_UMD|evm.model.AC_000167.1.192 Q9JKA7 HCN4_RAT 97.275 0.525386 0.75626 Hcn4 - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 - Rattus norvegicus (Rat) - Hcn4 gene Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih) (By similarity). May mediate responses to sour stimuli. Taurus_UMD|evm.model.AC_000167.1.193 Q7Z4M0 RE114_HUMAN 73.864 0.984375 0.962406 REC114 - Meiotic recombination protein REC114 - Homo sapiens (Human) - REC114 gene Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Taurus_UMD|evm.model.AC_000167.1.194 Q9Y639 NPTN_HUMAN 91.270 0.886926 0.711055 NPTN - Neuroplastin precursor - Homo sapiens (Human) - NPTN gene Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). Taurus_UMD|evm.model.AC_000167.1.195 Q5ZPR3 CD276_HUMAN 93.195 0.988764 1 CD276 - CD276 antigen precursor - Homo sapiens (Human) - CD276 gene May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. Taurus_UMD|evm.model.AC_000167.1.196 A7YWL5 INSY1_BOVIN 99.315 0.993174 1.00342 INSYN1 - Inhibitory synaptic factor 1 - Bos taurus (Bovine) - INSYN1 gene Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code. Taurus_UMD|evm.model.AC_000167.1.199 Q8IYX1 TBC21_HUMAN 92.262 0.994065 1.00298 TBC1D21 - TBC1 domain family member 21 - Homo sapiens (Human) - TBC1D21 gene May act as a GTPase-activating protein for Rab family protein(s) (PubMed:19077034). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (PubMed:21128978). Taurus_UMD|evm.model.AC_000167.1.201 Q17QH8 D39U1_BOVIN 99.660 0.99322 1.0034 SDR39U1 - Epimerase family protein SDR39U1 - Bos taurus (Bovine) - SDR39U1 gene Putative NADP-dependent oxidoreductase. Taurus_UMD|evm.model.AC_000167.1.202 O15037 KHNYN_HUMAN 81.606 0.997046 0.998525 KHNYN - Protein KHNYN - Homo sapiens (Human) - KHNYN gene cytoplasmic ribonucleoprotein granule, nucleus, endoribonuclease activity, mRNA binding, RNA phosphodiester bond hydrolysis, endonucleolytic Taurus_UMD|evm.model.AC_000167.1.203 Q17QF9 CBLN3_BOVIN 99.296 0.986014 0.697561 CBLN3 - Cerebellin-3 precursor - Bos taurus (Bovine) - CBLN3 gene May be involved in synaptic functions in the CNS. Taurus_UMD|evm.model.AC_000167.1.204 Q9P2P1 NYNRI_HUMAN 82.490 0.985908 0.972076 NYNRIN - Protein NYNRIN - Homo sapiens (Human) - NYNRIN gene cytoplasmic ribonucleoprotein granule, nucleus, endoribonuclease activity, mRNA binding, RNA phosphodiester bond hydrolysis, endonucleolytic Taurus_UMD|evm.model.AC_000167.1.205 Q14934 NFAC4_HUMAN 92.295 0.9728 0.692905 NFATC4 - Nuclear factor of activated T-cells, cytoplasmic 4 - Homo sapiens (Human) - NFATC4 gene Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:7749981, PubMed:11514544, PubMed:11997522, PubMed:17875713, PubMed:17213202, PubMed:18668201, PubMed:25663301). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:7749981, PubMed:18668201, PubMed:18347059). Along with NFATC3, involved in embryonic heart development. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). Taurus_UMD|evm.model.AC_000167.1.206 Q9Y572 RIPK3_HUMAN 63.566 0.99604 0.974903 RIPK3 - Receptor-interacting serine/threonine-protein kinase 3 - Homo sapiens (Human) - RIPK3 gene Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609). Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:29883609, PubMed:32298652). Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:19524512, PubMed:19524513, PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:25316792, PubMed:29883609). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity). Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL (PubMed:19498109). These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (PubMed:19498109). Taurus_UMD|evm.model.AC_000167.1.207 Q8NFM4 ADCY4_HUMAN 89.694 0.998075 0.964717 ADCY4 - Adenylate cyclase type 4 - Homo sapiens (Human) - ADCY4 gene Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Taurus_UMD|evm.model.AC_000167.1.208 Q3T181 LT4R1_BOVIN 100.000 0.87 1.14613 LTB4R - Leukotriene B4 receptor 1 - Bos taurus (Bovine) - LTB4R gene Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response (By similarity). Taurus_UMD|evm.model.AC_000167.1.209 Q9NPC1 LT4R2_HUMAN 91.036 0.991643 1.00279 LTB4R2 - Leukotriene B4 receptor 2 - Homo sapiens (Human) - LTB4R2 gene Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3. Taurus_UMD|evm.model.AC_000167.1.210 Q3T191 CIDEB_BOVIN 100.000 0.990909 1.00457 CIDEB - Cell death activator CIDE-B - Bos taurus (Bovine) - CIDEB gene Activates apoptosis. Taurus_UMD|evm.model.AC_000167.1.211 Q86U38 NOP9_HUMAN 88.679 0.99686 1.00157 NOP9 - Nucleolar protein 9 - Homo sapiens (Human) - NOP9 gene 90S preribosome, nucleolus, preribosome, small subunit precursor, RNA binding, endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit export from nucleus Taurus_UMD|evm.model.AC_000167.1.212 Q96LJ7 DHRS1_HUMAN 83.094 0.816568 1.07987 DHRS1 - Dehydrogenase/reductase SDR family member 1 - Homo sapiens (Human) - DHRS1 gene endoplasmic reticulum Taurus_UMD|evm.model.AC_000167.1.213 Q5EA80 PGTA_BOVIN 100.000 0.996479 1.00176 RABGGTA - Geranylgeranyl transferase type-2 subunit alpha - Bos taurus (Bovine) - RABGGTA gene Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. Taurus_UMD|evm.model.AC_000167.1.214 Q9GLK0 TGM1_CANLF 88.810 0.985849 1.04049 TGM1 - Protein-glutamine gamma-glutamyltransferase K - Canis lupus familiaris (Dog) - TGM1 gene Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000167.1.215 Q9BSI4 TINF2_HUMAN 78.634 0.995575 1.00222 TINF2 - TERF1-interacting nuclear factor 2 - Homo sapiens (Human) - TINF2 gene Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. Taurus_UMD|evm.model.AC_000167.1.216 Q9P2T1 GMPR2_HUMAN 95.312 0.684783 0.264368 GMPR2 - GMP reductase 2 - Homo sapiens (Human) - GMPR2 gene Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231). Taurus_UMD|evm.model.AC_000167.1.217 Q32L93 GMPR2_BOVIN 100.000 0.440162 1.41667 GMPR2 - GMP reductase 2 - Bos taurus (Bovine) - GMPR2 gene Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (Probable). Plays a role in modulating cellular differentiation (By similarity). Taurus_UMD|evm.model.AC_000167.1.218 A2VDY3 CHM4A_BOVIN 100.000 0.991031 1.0045 CHMP4A - Charged multivesicular body protein 4a - Bos taurus (Bovine) - CHMP4A gene Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Taurus_UMD|evm.model.AC_000167.1.219 Q9D411 TSSK4_MOUSE 86.826 0.993994 1.01524 Tssk4 - Testis-specific serine/threonine-protein kinase 4 - Mus musculus (Mouse) - Tssk4 gene Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (PubMed:17927909, PubMed:23599433, PubMed:23054012, PubMed:25361759, PubMed:26940607). May be involved in the Cre/Creb signaling pathway (PubMed:26940607). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (By similarity). Phosphorylates CREM on 'Ser-116' in vitro (PubMed:26940607). Phosphorylates ODF2 on 'Ser-95' (PubMed:26961893). Taurus_UMD|evm.model.AC_000167.1.221 P16423 POLR_DROME 31.897 0.826087 0.130558 pol - Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM - Drosophila melanogaster (Fruit fly) - pol gene Taurus_UMD|evm.model.AC_000167.1.222 A4IFE9 TM9S1_BOVIN 99.835 0.996705 1.00165 TM9SF1 - Transmembrane 9 superfamily member 1 precursor - Bos taurus (Bovine) - TM9SF1 gene Plays an essential role in autophagy. Taurus_UMD|evm.model.AC_000167.1.223 Q8TEX9 IPO4_HUMAN 90.472 0.998152 1.00093 IPO4 - Importin-4 - Homo sapiens (Human) - IPO4 gene Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Taurus_UMD|evm.model.AC_000167.1.224 O95072 REC8_HUMAN 76.239 0.993103 1.06033 REC8 - Meiotic recombination protein REC8 homolog - Homo sapiens (Human) - REC8 gene Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity). Taurus_UMD|evm.model.AC_000167.1.225 Q96EP0 RNF31_HUMAN 88.363 0.704545 1.39552 RNF31 - E3 ubiquitin-protein ligase RNF31 - Homo sapiens (Human) - RNF31 gene E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). Taurus_UMD|evm.model.AC_000167.1.226 Q5E9G3 PSME2_BOVIN 100.000 0.991667 1.00418 PSME2 - Proteasome activator complex subunit 2 - Bos taurus (Bovine) - PSME2 gene Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Taurus_UMD|evm.model.AC_000167.1.227 Q9Y3B6 EMC9_HUMAN 93.237 0.985646 1.00481 EMC9 - ER membrane protein complex subunit 9 - Homo sapiens (Human) - EMC9 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). Taurus_UMD|evm.model.AC_000167.1.228 Q4U5R3 PSME1_BOVIN 99.598 0.992 1.00402 PSME1 - Proteasome activator complex subunit 1 - Bos taurus (Bovine) - PSME1 gene Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Taurus_UMD|evm.model.AC_000167.1.229 A7YWN2 FITM1_BOVIN 100.000 0.993174 1.00342 FITM1 - Fat storage-inducing transmembrane protein 1 - Bos taurus (Bovine) - FITM1 gene Plays an important role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol (By similarity). Taurus_UMD|evm.model.AC_000167.1.231 Q5E9I8 DCA11_BOVIN 99.817 0.996344 1.00183 DCAF11 - DDB1- and CUL4-associated factor 11 - Bos taurus (Bovine) - DCAF11 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Taurus_UMD|evm.model.AC_000167.1.232 Q16822 PCKGM_HUMAN 94.688 0.99688 1.00156 PCK2 - Phosphoenolpyruvate carboxykinase [GTP], mitochondrial precursor - Homo sapiens (Human) - PCK2 gene Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Taurus_UMD|evm.model.AC_000167.1.233 P54845 NRL_HUMAN 93.860 0.863118 1.1097 NRL - Neural retina-specific leucine zipper protein - Homo sapiens (Human) - NRL gene Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001). Taurus_UMD|evm.model.AC_000167.1.234 Q2KHY1 CPNE6_BOVIN 98.759 0.285932 3.53501 CPNE6 - Copine-6 - Bos taurus (Bovine) - CPNE6 gene Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes. Taurus_UMD|evm.model.AC_000167.1.236 Q8SPU8 DHRS4_BOVIN 99.642 0.992857 1.00358 DHRS4 - Dehydrogenase/reductase SDR family member 4 - Bos taurus (Bovine) - DHRS4 gene Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). Taurus_UMD|evm.model.AC_000167.1.237 P0CG22 DR4L1_HUMAN 73.171 0.547945 0.259786 DHRS4L1 - Putative dehydrogenase/reductase SDR family member 4-like 1 - Homo sapiens (Human) - DHRS4L1 gene Putative oxidoreductase. Taurus_UMD|evm.model.AC_000167.1.238 Q9TT13 VDAC3_RABIT 72.112 0.99 0.706714 VDAC3 - Voltage-dependent anion-selective channel protein 3 - Oryctolagus cuniculus (Rabbit) - VDAC3 gene Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. Taurus_UMD|evm.model.AC_000167.1.239 P20821 GCSH_BOVIN 93.064 0.988506 1.00578 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Taurus_UMD|evm.model.AC_000167.1.240 Q69FB3 JPH4_RAT 96.480 0.992051 0.998413 Jph4 - Junctophilin-4 - Rattus norvegicus (Rat) - Jph4 gene Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity). Taurus_UMD|evm.model.AC_000167.1.241 O75843 AP1G2_HUMAN 89.554 0.79112 1.26242 AP1G2 - AP-1 complex subunit gamma-like 2 - Homo sapiens (Human) - AP1G2 gene May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Taurus_UMD|evm.model.AC_000167.1.242 Q8MKF1 THTPA_BOVIN 100.000 0.990909 1.00457 THTPA - Thiamine-triphosphatase - Bos taurus (Bovine) - THTPA gene Hydrolase highly specific for thiamine triphosphate (ThTP). Taurus_UMD|evm.model.AC_000167.1.243 Q9C0A1 ZFHX2_HUMAN 86.477 0.995334 1 ZFHX2 - Zinc finger homeobox protein 2 - Homo sapiens (Human) - ZFHX2 gene Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli. Taurus_UMD|evm.model.AC_000167.1.244 Q2KII6 NGDN_BOVIN 100.000 0.993671 1.00317 NGDN - Neuroguidin - Bos taurus (Bovine) - NGDN gene Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs. Taurus_UMD|evm.model.AC_000167.1.245 Q9BE39 MYH7_BOVIN 97.927 0.500919 1.96848 MYH7 - Myosin-7 - Bos taurus (Bovine) - MYH7 gene Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Taurus_UMD|evm.model.AC_000167.1.246 Q96DZ9 CKLF5_HUMAN 93.651 0.181818 1.52915 CMTM5 - CKLF-like MARVEL transmembrane domain-containing protein 5 - Homo sapiens (Human) - CMTM5 gene integral component of membrane Taurus_UMD|evm.model.AC_000167.1.247 O43281 EFS_HUMAN 86.453 0.91954 1.08556 EFS - Embryonal Fyn-associated substrate - Homo sapiens (Human) - EFS gene Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity). Taurus_UMD|evm.model.AC_000167.1.248 Q3SZQ2 S22AH_BOVIN 100.000 0.797183 1.2522 SLC22A17 - Solute carrier family 22 member 17 - Bos taurus (Bovine) - SLC22A17 gene Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity). Taurus_UMD|evm.model.AC_000167.1.249 Q28165 PABP2_BOVIN 100.000 0.993485 1.00327 PABPN1 - Polyadenylate-binding protein 2 - Bos taurus (Bovine) - PABPN1 gene Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (PubMed:7479061, PubMed:10481015). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (PubMed:12637556). Increases the affinity of poly(A) polymerase for RNA (PubMed:12637556, PubMed:12853485). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (By similarity). Binds to poly(A) and to poly(G) with high affinity (PubMed:7479061, PubMed:12637556). May protect the poly(A) tail from degradation (PubMed:7479061). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (By similarity). Taurus_UMD|evm.model.AC_000167.1.250 Q45T69 B2CL2_CANLF 100.000 0.989691 1.00518 BCL2L2 - Bcl-2-like protein 2 - Canis lupus familiaris (Dog) - BCL2L2 gene Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX (By similarity). Taurus_UMD|evm.model.AC_000167.1.251 Q9H7J1 PPR3E_HUMAN 91.398 0.992857 1.00358 PPP1R3E - Protein phosphatase 1 regulatory subunit 3E - Homo sapiens (Human) - PPP1R3E gene Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis. Taurus_UMD|evm.model.AC_000167.1.252 Q8IX15 HOMEZ_HUMAN 86.550 0.933333 0.981818 HOMEZ - Homeobox and leucine zipper protein Homez - Homo sapiens (Human) - HOMEZ gene May function as a transcriptional regulator. Taurus_UMD|evm.model.AC_000167.1.253 A8MTL3 R212B_HUMAN 85.214 0.941176 0.906667 RNF212B - RING finger protein 212B - Homo sapiens (Human) - RNF212B gene synaptonemal complex, SUMO transferase activity, homologous chromosome pairing at meiosis, protein sumoylation Taurus_UMD|evm.model.AC_000167.1.254 Q9UHI5 LAT2_HUMAN 90.207 0.994329 0.988785 SLC7A8 - Large neutral amino acids transporter small subunit 2 - Homo sapiens (Human) - SLC7A8 gene Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. Taurus_UMD|evm.model.AC_000167.1.256 O77728 CEBPE_SHEEP 98.577 0.992908 1.00356 CEBPE - CCAAT/enhancer-binding protein epsilon - Ovis aries (Sheep) - CEBPE gene Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation. Taurus_UMD|evm.model.AC_000167.1.257 Q9JJ93 CN119_MOUSE 88.732 0.986014 1.00704 MNCb-2990 - Uncharacterized protein C14orf119 homolog - Mus musculus (Mouse) - MNCb-2990 gene cytosol, mitochondrion Taurus_UMD|evm.model.AC_000167.1.258 Q9UKV3 ACINU_HUMAN 91.878 0.998502 0.995526 ACIN1 - Apoptotic chromatin condensation inducer in the nucleus - Homo sapiens (Human) - ACIN1 gene Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. Taurus_UMD|evm.model.AC_000167.1.259 Q6PFX6 CAD24_MOUSE 93.982 0.975 1.02433 Cdh24 - Cadherin-24 precursor - Mus musculus (Mouse) - Cdh24 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion (By similarity). Taurus_UMD|evm.model.AC_000167.1.260 A5LHX3 PSB11_HUMAN 83.333 0.97931 0.966667 PSMB11 - Proteasome subunit beta type-11 precursor - Homo sapiens (Human) - PSMB11 gene The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity). Taurus_UMD|evm.model.AC_000167.1.261 Q32KL2 PSB5_BOVIN 100.000 0.992424 1.0038 PSMB5 - Proteasome subunit beta type-5 precursor - Bos taurus (Bovine) - PSMB5 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity. Taurus_UMD|evm.model.AC_000167.1.262 Q9H972 CN093_HUMAN 91.111 0.996303 1.00558 C14orf93 - Uncharacterized protein C14orf93 precursor - Homo sapiens (Human) - C14orf93 gene RNA binding Taurus_UMD|evm.model.AC_000167.1.263 E1BKA3 AJUBA_BOVIN 100.000 0.996357 1.00182 AJUBA - LIM domain-containing protein ajuba - Bos taurus (Bovine) - AJUBA gene Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1 (By similarity). Taurus_UMD|evm.model.AC_000167.1.264 Q9H6D7 HAUS4_HUMAN 87.879 0.994505 1.00275 HAUS4 - HAUS augmin-like complex subunit 4 - Homo sapiens (Human) - HAUS4 gene Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Taurus_UMD|evm.model.AC_000167.1.265 A7YW45 ANM5_BOVIN 99.843 0.996865 1.00157 PRMT5 - Protein arginine N-methyltransferase 5 - Bos taurus (Bovine) - PRMT5 gene Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its transcriptional elongation properties (By similarity). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9. Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (By similarity). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation. Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner. Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression. Symmetrically methylates NCL (By similarity). Methylates TP53; methylation might possibly affect TP53 target gene specificity (By similarity). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein B) and the interaction with tudor domain-containing protein TDRD6 (By similarity). Taurus_UMD|evm.model.AC_000167.1.266 Q86U06 RBM23_HUMAN 85.097 0.99569 1.05695 RBM23 - Probable RNA-binding protein 23 - Homo sapiens (Human) - RBM23 gene RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor (PubMed:15694343). Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity (PubMed:15694343). Taurus_UMD|evm.model.AC_000167.1.267 Q8IYK8 REM2_HUMAN 94.118 0.994135 1.00294 REM2 - GTP-binding protein REM 2 - Homo sapiens (Human) - REM2 gene Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis. Taurus_UMD|evm.model.AC_000167.1.268 Q7Z4F1 LRP10_HUMAN 89.368 0.974755 1 LRP10 - Low-density lipoprotein receptor-related protein 10 precursor - Homo sapiens (Human) - LRP10 gene Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity). Taurus_UMD|evm.model.AC_000167.1.269 Q9GLE4 MMP14_BOVIN 98.915 0.989247 0.958763 MMP14 - Matrix metalloproteinase-14 precursor - Bos taurus (Bovine) - MMP14 gene Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis. Taurus_UMD|evm.model.AC_000167.1.270 P0C2B7 RM52_BOVIN 100.000 0.647368 1.53226 MRPL52 - 39S ribosomal protein L52, mitochondrial precursor - Bos taurus (Bovine) - MRPL52 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000167.1.271 Q9UM01 YLAT1_HUMAN 90.411 0.942699 1.05871 SLC7A7 - Y+L amino acid transporter 1 - Homo sapiens (Human) - SLC7A7 gene Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Taurus_UMD|evm.model.AC_000167.1.272 Q3SYV3 OXA1L_BOVIN 100.000 0.995475 1.00227 OXA1L - Mitochondrial inner membrane protein OXA1L precursor - Bos taurus (Bovine) - OXA1L gene Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria (By similarity). Taurus_UMD|evm.model.AC_000167.1.273 Q90835 EF1A_CHICK 70.455 0.380531 0.244589 EEF1A - Elongation factor 1-alpha 1 - Gallus gallus (Chicken) - EEF1A gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Taurus_UMD|evm.model.AC_000167.1.274 Q02370 NDUA2_BOVIN 98.901 0.508475 1.78788 NDUFA2 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 - Bos taurus (Bovine) - NDUFA2 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000167.1.275 Q8NGC5 OR6J1_HUMAN 73.554 0.712575 0.481268 OR6J1 - Olfactory receptor 6J1 - Homo sapiens (Human) - OR6J1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000167.1.276 P29693 EF1D_XENLA 83.951 0.473373 0.637736 eef1d - Elongation factor 1-delta - Xenopus laevis (African clawed frog) - eef1d gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Taurus_UMD|evm.model.AC_000167.1.277 P62936 PPIA_PIG 98.780 0.987879 1.0061 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Taurus_UMD|evm.model.AC_000167.1.278 P29693 EF1D_XENLA 83.951 0.473373 0.637736 eef1d - Elongation factor 1-delta - Xenopus laevis (African clawed frog) - eef1d gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Taurus_UMD|evm.model.AC_000167.1.279 P62936 PPIA_PIG 98.780 0.987879 1.0061 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Taurus_UMD|evm.model.AC_000167.1.280 Q5EA59 ABHD4_BOVIN 100.000 0.957865 1.04094 ABHD4 - (Lyso)-N-acylphosphatidylethanolamine lipase - Bos taurus (Bovine) - ABHD4 gene Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine. Taurus_UMD|evm.model.AC_000167.1.281 Q5E9C2 DAD1_BOVIN 100.000 0.982456 1.00885 DAD1 - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 - Bos taurus (Bovine) - DAD1 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Taurus_UMD|evm.model.AC_000167.1.282 P01848 TRAC_HUMAN 61.111 0.858025 1.15714 TRAC - T cell receptor alpha chain constant - Homo sapiens (Human) - TRAC gene Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.283 B7Z8K6 TRDC_HUMAN 66.667 0.864407 1.15686 TRDC - T cell receptor delta constant - Homo sapiens (Human) - TRDC gene Constant region of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.284 Q99877 H2B1N_HUMAN 91.045 0.970149 0.531746 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000167.1.285 A0JD36 TRDV2_HUMAN 65.217 0.857143 1.15652 TRDV2 - T cell receptor delta variable 2 precursor - Homo sapiens (Human) - TRDV2 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.286 A0JD36 TRDV2_HUMAN 38.182 0.668712 1.41739 TRDV2 - T cell receptor delta variable 2 precursor - Homo sapiens (Human) - TRDV2 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.287 A0A0A6YYC5 TVA14_HUMAN 48.315 0.26875 2.75862 TRAV14DV4 - T cell receptor alpha variable 14/delta variable 4 precursor - Homo sapiens (Human) - TRAV14DV4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.288 P46410 GLNA_PIG 58.599 0.983051 0.316354 GLUL - Glutamine synthetase - Sus scrofa (Pig) - GLUL gene Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). Taurus_UMD|evm.model.AC_000167.1.289 P15103 GLNA_BOVIN 83.523 0.94086 0.49866 GLUL - Glutamine synthetase - Bos taurus (Bovine) - GLUL gene Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). Taurus_UMD|evm.model.AC_000167.1.290 A0A0B4J266 TVA41_HUMAN 62.500 0.738255 1.33036 TRAV41 - T cell receptor alpha variable 41 precursor - Homo sapiens (Human) - TRAV41 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.291 A0JD32 TV382_HUMAN 69.298 0.949153 1.01724 TRAV38-2DV8 - T cell receptor alpha variable 38-2/delta variable 8 precursor - Homo sapiens (Human) - TRAV38-2DV8 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.292 A0A0B4J277 TVA22_HUMAN 60.674 0.458333 1.74545 TRAV22 - T cell receptor alpha variable 22 precursor - Homo sapiens (Human) - TRAV22 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.293 A0A0B4J265 TVAZ2_HUMAN 62.766 0.588608 1.44954 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.294 A0A1B0GX56 TRDV1_HUMAN 63.478 0.596859 1.66087 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.295 A0A0B4J265 TVAZ2_HUMAN 70.652 0.572327 1.45872 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.296 A0A1B0GX56 TRDV1_HUMAN 66.087 0.942149 1.05217 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.297 A0A0B4J276 TVA25_HUMAN 63.441 0.661871 1.27523 TRAV25 - T cell receptor alpha variable 25 precursor - Homo sapiens (Human) - TRAV25 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.298 A0A1B0GX56 TRDV1_HUMAN 66.667 0.267898 3.76522 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.299 A0A1B0GX56 TRDV1_HUMAN 60.870 0.727273 1.33913 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.300 A0A1B0GX56 TRDV1_HUMAN 65.812 0.644444 1.56522 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.301 A0A1B0GX56 TRDV1_HUMAN 63.559 0.735849 1.38261 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.302 A0A1B0GX56 TRDV1_HUMAN 66.667 0.297806 2.77391 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.303 A0A1B0GX56 TRDV1_HUMAN 61.616 0.254642 3.27826 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.304 A0A0B4J272 TVA24_HUMAN 73.438 0.174033 3.17544 TRAV24 - T cell receptor alpha variable 24 precursor - Homo sapiens (Human) - TRAV24 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.305 A0A1B0GX56 TRDV1_HUMAN 71.717 0.411765 2.06957 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.306 A0A1B0GX56 TRDV1_HUMAN 73.196 0.376471 2.21739 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.307 A0A0B4J265 TVAZ2_HUMAN 66.972 0.715232 1.38532 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.308 A0A1B0GX56 TRDV1_HUMAN 62.745 0.612121 1.43478 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.309 A0JD32 TV382_HUMAN 74.561 0.94958 1.02586 TRAV38-2DV8 - T cell receptor alpha variable 38-2/delta variable 8 precursor - Homo sapiens (Human) - TRAV38-2DV8 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.310 A0JD32 TV382_HUMAN 72.807 0.94958 1.02586 TRAV38-2DV8 - T cell receptor alpha variable 38-2/delta variable 8 precursor - Homo sapiens (Human) - TRAV38-2DV8 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.311 A0A0B4J234 TVA2_HUMAN 33.696 0.716535 1.13393 TRAV2 - T cell receptor alpha variable 2 precursor - Homo sapiens (Human) - TRAV2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.312 P0DPF4 TVA35_HUMAN 74.194 0.328571 2.54545 TRAV35 - T cell receptor alpha variable 35 precursor - Homo sapiens (Human) - TRAV35 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.313 P01737 TVA84_HUMAN 69.792 0.272206 3.0885 TRAV8-4 - T cell receptor alpha variable 8-4 precursor - Homo sapiens (Human) - TRAV8-4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.314 A0A0B4J265 TVAZ2_HUMAN 64.130 0.283489 2.94495 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.315 P04437 TVA29_HUMAN 65.217 0.249084 2.29412 TRAV29DV5 - T cell receptor alpha variable 29/delta variable 5 precursor - Homo sapiens (Human) - TRAV29DV5 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.316 P04437 TVA29_HUMAN 74.359 0.168142 1.89916 TRAV29DV5 - T cell receptor alpha variable 29/delta variable 5 precursor - Homo sapiens (Human) - TRAV29DV5 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.317 A0A1B0GX56 TRDV1_HUMAN 70.435 0.596859 1.66087 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.318 A0A0B4J265 TVAZ2_HUMAN 60.294 0.446667 1.37615 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.319 A0A1B0GX56 TRDV1_HUMAN 70.435 0.350769 2.82609 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.320 A0A0B4J279 TVA21_HUMAN 71.875 0.601266 1.41071 TRAV21 - T cell receptor alpha variable 21 precursor - Homo sapiens (Human) - TRAV21 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.321 A0A0B4J274 TVA20_HUMAN 80.357 0.834586 1.1875 TRAV20 - T cell receptor alpha variable 20 precursor - Homo sapiens (Human) - TRAV20 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.322 A0A075B6X5 TVA18_HUMAN 73.000 0.510309 1.74775 TRAV18 - T cell receptor alpha variable 18 precursor - Homo sapiens (Human) - TRAV18 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.323 A0A0B4J271 TVAL3_HUMAN 65.263 0.676259 1.2193 TRAV12-3 - T cell receptor alpha variable 12-3 precursor - Homo sapiens (Human) - TRAV12-3 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.324 A0A0A6YYC5 TVA14_HUMAN 76.724 0.934959 1.06034 TRAV14DV4 - T cell receptor alpha variable 14/delta variable 4 precursor - Homo sapiens (Human) - TRAV14DV4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.325 A0A0B4J241 TVAM1_HUMAN 72.727 0.817204 0.830357 TRAV13-1 - T cell receptor alpha variable 13-1 precursor - Homo sapiens (Human) - TRAV13-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.326 A0A087WT02 TVA92_HUMAN 70.536 0.435294 2.27679 TRAV9-2 - T cell receptor alpha variable 9-2 precursor - Homo sapiens (Human) - TRAV9-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.327 A0A0B4J277 TVA22_HUMAN 64.545 0.825758 1.2 TRAV22 - T cell receptor alpha variable 22 precursor - Homo sapiens (Human) - TRAV22 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.328 A0A1B0GX56 TRDV1_HUMAN 67.677 0.300613 2.83478 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.329 A0A0B4J265 TVAZ2_HUMAN 68.478 0.284375 2.93578 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.330 A0A1B0GX56 TRDV1_HUMAN 69.565 0.942149 1.05217 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.331 A0A0B4J265 TVAZ2_HUMAN 68.478 0.464286 1.79817 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.332 A0A0B4J277 TVA22_HUMAN 65.672 0.160584 3.73636 TRAV22 - T cell receptor alpha variable 22 precursor - Homo sapiens (Human) - TRAV22 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.333 A0A0B4J265 TVAZ2_HUMAN 69.792 0.283582 3.07339 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.334 A0A1B0GX56 TRDV1_HUMAN 61.905 0.42449 2.13043 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.335 A0A0B4J279 TVA21_HUMAN 69.863 0.380952 1.6875 TRAV21 - T cell receptor alpha variable 21 precursor - Homo sapiens (Human) - TRAV21 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.336 A0A0B4J274 TVA20_HUMAN 80.357 0.832061 1.16964 TRAV20 - T cell receptor alpha variable 20 precursor - Homo sapiens (Human) - TRAV20 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.337 O15439 MRP4_HUMAN 66.013 0.878613 0.130566 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000167.1.338 A0A1B0GX56 TRDV1_HUMAN 65.347 0.549451 1.58261 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.339 A0A0B4J265 TVAZ2_HUMAN 69.725 0.459574 2.15596 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.340 A0A075B6X5 TVA18_HUMAN 62.832 0.459016 2.1982 TRAV18 - T cell receptor alpha variable 18 precursor - Homo sapiens (Human) - TRAV18 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.341 A0A075B6X5 TVA18_HUMAN 65.179 0.867188 1.15315 TRAV18 - T cell receptor alpha variable 18 precursor - Homo sapiens (Human) - TRAV18 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.342 A0A075B6X5 TVA18_HUMAN 61.446 0.471264 1.56757 TRAV18 - T cell receptor alpha variable 18 precursor - Homo sapiens (Human) - TRAV18 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.343 A0A075B6X5 TVA18_HUMAN 79.570 0.609272 1.36036 TRAV18 - T cell receptor alpha variable 18 precursor - Homo sapiens (Human) - TRAV18 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.344 A0A0B4J275 TVA17_HUMAN 69.912 0.647399 1.54464 TRAV17 - T cell receptor alpha variable 17 precursor - Homo sapiens (Human) - TRAV17 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.345 A0A0A6YYK6 TVA16_HUMAN 77.778 0.685897 1.43119 TRAV16 - T cell receptor alpha variable 16 precursor - Homo sapiens (Human) - TRAV16 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.346 P01739 TVA2_MOUSE 64.211 0.298413 2.38636 T-cell receptor alpha chain V region 2B4 precursor - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000167.1.347 A0A0A6YYC5 TVA14_HUMAN 76.744 0.282392 2.59483 TRAV14DV4 - T cell receptor alpha variable 14/delta variable 4 precursor - Homo sapiens (Human) - TRAV14DV4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.348 A0A0B4J265 TVAZ2_HUMAN 67.890 0.715232 1.38532 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.349 A0A1B0GX56 TRDV1_HUMAN 63.478 0.77551 1.27826 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.350 A0A1B0GX56 TRDV1_HUMAN 67.826 0.942149 1.05217 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.351 A0A1B0GX56 TRDV1_HUMAN 66.667 0.59375 1.3913 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.352 A0A1B0GX56 TRDV1_HUMAN 61.739 0.670588 1.47826 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.353 A0A1B0GX56 TRDV1_HUMAN 64.348 0.596859 1.66087 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.354 A0A0A6YYJ7 TVA83_HUMAN 72.321 0.720779 1.36283 TRAV8-3 - T cell receptor alpha variable 8-3 precursor - Homo sapiens (Human) - TRAV8-3 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.355 A0A0B4J265 TVAZ2_HUMAN 61.446 0.427083 1.76147 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.356 A0A1B0GX56 TRDV1_HUMAN 58.974 0.601036 1.67826 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.357 P01737 TVA84_HUMAN 72.857 0.188011 3.24779 TRAV8-4 - T cell receptor alpha variable 8-4 precursor - Homo sapiens (Human) - TRAV8-4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.358 A0A075B6T8 TVA91_HUMAN 75.000 0.813725 0.910714 TRAV9-1 - T cell receptor alpha variable 9-1 precursor - Homo sapiens (Human) - TRAV9-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.359 A0A075B6X5 TVA18_HUMAN 63.393 0.867188 1.15315 TRAV18 - T cell receptor alpha variable 18 precursor - Homo sapiens (Human) - TRAV18 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.360 P01739 TVA2_MOUSE 64.516 0.486772 1.43182 T-cell receptor alpha chain V region 2B4 precursor - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000167.1.361 A0A0A6YYC5 TVA14_HUMAN 75.000 0.966387 1.02586 TRAV14DV4 - T cell receptor alpha variable 14/delta variable 4 precursor - Homo sapiens (Human) - TRAV14DV4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.362 A0A0B4J241 TVAM1_HUMAN 75.000 0.417431 1.94643 TRAV13-1 - T cell receptor alpha variable 13-1 precursor - Homo sapiens (Human) - TRAV13-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.363 A0A0B4J249 TVA5_HUMAN 63.366 0.840336 1.0531 TRAV5 - T cell receptor alpha variable 5 precursor - Homo sapiens (Human) - TRAV5 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.364 A0A0B4J268 TVA4_HUMAN 74.312 0.964286 1.02752 TRAV4 - T cell receptor alpha variable 4 precursor - Homo sapiens (Human) - TRAV4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.365 A0A1B0GX56 TRDV1_HUMAN 64.348 0.633333 1.56522 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.366 A0A0B4J277 TVA22_HUMAN 61.818 0.694268 1.42727 TRAV22 - T cell receptor alpha variable 22 precursor - Homo sapiens (Human) - TRAV22 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.367 A0A087WT02 TVA92_HUMAN 74.713 0.843137 0.910714 TRAV9-2 - T cell receptor alpha variable 9-2 precursor - Homo sapiens (Human) - TRAV9-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.368 A0A1B0GX56 TRDV1_HUMAN 60.000 0.670588 1.47826 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.369 A0A1B0GX56 TRDV1_HUMAN 65.217 0.863636 1.14783 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.370 P01737 TVA84_HUMAN 66.337 0.757576 1.16814 TRAV8-4 - T cell receptor alpha variable 8-4 precursor - Homo sapiens (Human) - TRAV8-4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.371 A0A087WT03 TVAZ1_HUMAN 66.316 0.155372 5.55046 TRAV26-1 - T cell receptor alpha variable 26-1 precursor - Homo sapiens (Human) - TRAV26-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.372 A0A1B0GX56 TRDV1_HUMAN 60.000 0.596859 1.66087 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.373 A0A087WT03 TVAZ1_HUMAN 60.638 0.299035 2.85321 TRAV26-1 - T cell receptor alpha variable 26-1 precursor - Homo sapiens (Human) - TRAV26-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.374 A0A1B0GX56 TRDV1_HUMAN 69.388 0.60625 1.3913 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.375 A0A0B4J265 TVAZ2_HUMAN 65.060 0.344538 2.18349 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.376 A0A1B0GX56 TRDV1_HUMAN 67.826 0.942149 1.05217 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.377 A0A0B4J276 TVA25_HUMAN 58.696 0.710938 1.17431 TRAV25 - T cell receptor alpha variable 25 precursor - Homo sapiens (Human) - TRAV25 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.378 A0A0B4J277 TVA22_HUMAN 69.091 0.908333 1.09091 TRAV22 - T cell receptor alpha variable 22 precursor - Homo sapiens (Human) - TRAV22 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.379 A0A0B4J265 TVAZ2_HUMAN 69.565 0.348659 2.3945 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.380 A0A1B0GX56 TRDV1_HUMAN 58.974 0.601036 1.67826 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.381 A0A075B6X5 TVA18_HUMAN 70.408 0.259358 3.36937 TRAV18 - T cell receptor alpha variable 18 precursor - Homo sapiens (Human) - TRAV18 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.382 A0A0A6YYC5 TVA14_HUMAN 76.724 0.934959 1.06034 TRAV14DV4 - T cell receptor alpha variable 14/delta variable 4 precursor - Homo sapiens (Human) - TRAV14DV4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.383 A0A0B4J241 TVAM1_HUMAN 72.826 0.317073 2.5625 TRAV13-1 - T cell receptor alpha variable 13-1 precursor - Homo sapiens (Human) - TRAV13-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.384 A0A087WT03 TVAZ1_HUMAN 69.643 0.180328 2.79817 TRAV26-1 - T cell receptor alpha variable 26-1 precursor - Homo sapiens (Human) - TRAV26-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.385 A0A0B4J249 TVA5_HUMAN 66.964 0.853846 1.15044 TRAV5 - T cell receptor alpha variable 5 precursor - Homo sapiens (Human) - TRAV5 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.386 A0A0B4J268 TVA4_HUMAN 77.083 0.354478 2.45872 TRAV4 - T cell receptor alpha variable 4 precursor - Homo sapiens (Human) - TRAV4 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.387 A0A1B0GX56 TRDV1_HUMAN 66.087 0.926829 1.06957 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.388 A0A075B6X5 TVA18_HUMAN 79.570 0.29582 2.8018 TRAV18 - T cell receptor alpha variable 18 precursor - Homo sapiens (Human) - TRAV18 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.389 A0A075B6X5 TVA18_HUMAN 77.660 0.611842 1.36937 TRAV18 - T cell receptor alpha variable 18 precursor - Homo sapiens (Human) - TRAV18 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.390 A0A075B6X5 TVA18_HUMAN 65.179 0.895161 1.11712 TRAV18 - T cell receptor alpha variable 18 precursor - Homo sapiens (Human) - TRAV18 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.391 P06322 TVA1_RABIT 71.795 0.219653 1.29104 T-cell receptor alpha chain V region RL-5 precursor - Oryctolagus cuniculus (Rabbit) Taurus_UMD|evm.model.AC_000167.1.392 A0A1B0GX56 TRDV1_HUMAN 68.696 0.942149 1.05217 TRDV1 - T cell receptor delta variable 1 precursor - Homo sapiens (Human) - TRDV1 gene V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714). Taurus_UMD|evm.model.AC_000167.1.393 A0A087WT03 TVAZ1_HUMAN 65.741 0.324242 3.02752 TRAV26-1 - T cell receptor alpha variable 26-1 precursor - Homo sapiens (Human) - TRAV26-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.394 P06323 TVA3_MOUSE 65.957 0.510989 1.37879 T-cell receptor alpha chain V region CTL-F3 precursor - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000167.1.395 A0A075B6T6 TVAL2_HUMAN 64.211 0.661972 1.25664 TRAV12-2 - T cell receptor alpha variable 12-2 precursor - Homo sapiens (Human) - TRAV12-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.396 A0A0B4J241 TVAM1_HUMAN 67.857 0.859375 1.14286 TRAV13-1 - T cell receptor alpha variable 13-1 precursor - Homo sapiens (Human) - TRAV13-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.397 A0A087WT02 TVA92_HUMAN 72.973 0.21611 4.54464 TRAV9-2 - T cell receptor alpha variable 9-2 precursor - Homo sapiens (Human) - TRAV9-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.398 A0A0B4J265 TVAZ2_HUMAN 70.408 0.253264 3.51376 TRAV26-2 - T cell receptor alpha variable 26-2 precursor - Homo sapiens (Human) - TRAV26-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.399 A0A0B4J274 TVA20_HUMAN 76.596 0.371429 2.1875 TRAV20 - T cell receptor alpha variable 20 precursor - Homo sapiens (Human) - TRAV20 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.400 A0A0B4J244 TVA3_HUMAN 81.373 0.495098 1.78947 TRAV3 - T cell receptor alpha variable 3 precursor - Homo sapiens (Human) - TRAV3 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.401 A0A0B4J234 TVA2_HUMAN 79.279 0.916667 1.07143 TRAV2 - T cell receptor alpha variable 2 precursor - Homo sapiens (Human) - TRAV2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.402 A0A0B4J244 TVA3_HUMAN 82.653 0.505208 1.68421 TRAV3 - T cell receptor alpha variable 3 precursor - Homo sapiens (Human) - TRAV3 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.403 A0A0B4J244 TVA3_HUMAN 78.947 0.758389 1.30702 TRAV3 - T cell receptor alpha variable 3 precursor - Homo sapiens (Human) - TRAV3 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.404 A0A0B4J244 TVA3_HUMAN 83.133 0.267101 2.69298 TRAV3 - T cell receptor alpha variable 3 precursor - Homo sapiens (Human) - TRAV3 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.405 P10854 H2B1M_MOUSE 89.744 0.5 0.603175 H2bc14 - Histone H2B type 1-M - Mus musculus (Mouse) - H2bc14 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000167.1.406 Q8NGC4 O10G3_HUMAN 84.659 0.631769 0.884984 OR10G3 - Olfactory receptor 10G3 - Homo sapiens (Human) - OR10G3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000167.1.407 Q8VD88 RNS1D_RAT 35.000 0.742188 0.853333 Rnase1d - Ribonuclease pancreatic delta-type precursor - Rattus norvegicus (Rat) - Rnase1d gene Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA (By similarity). Taurus_UMD|evm.model.AC_000167.1.408 Q9Y467 SALL2_HUMAN 91.097 0.873636 1.09235 SALL2 - Sal-like protein 2 - Homo sapiens (Human) - SALL2 gene Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure. Taurus_UMD|evm.model.AC_000167.1.409 Q86U44 MTA70_HUMAN 97.931 0.996558 1.00172 METTL3 - N6-adenosine-methyltransferase catalytic subunit - Homo sapiens (Human) - METTL3 gene The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:28297716, PubMed:30428350, PubMed:29506078, PubMed:29348140, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). Taurus_UMD|evm.model.AC_000167.1.410 Q0P5K4 TOX4_BOVIN 100.000 0.996774 1.00162 TOX4 - TOX high mobility group box family member 4 - Bos taurus (Bovine) - TOX4 gene Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Taurus_UMD|evm.model.AC_000167.1.411 Q8WUD1 RAB2B_HUMAN 96.759 0.990783 1.00463 RAB2B - Ras-related protein Rab-2B - Homo sapiens (Human) - RAB2B gene Required for protein transport from the endoplasmic reticulum to the Golgi complex. Taurus_UMD|evm.model.AC_000167.1.412 Q9HCK8 CHD8_HUMAN 95.819 0.999208 0.97869 CHD8 - Chromodomain-helicase-DNA-binding protein 8 - Homo sapiens (Human) - CHD8 gene DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Taurus_UMD|evm.model.AC_000167.1.413 Q9Y5B9 SP16H_HUMAN 99.713 0.998092 1.00096 SUPT16H - FACT complex subunit SPT16 - Homo sapiens (Human) - SUPT16H gene Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Taurus_UMD|evm.model.AC_000167.1.414 Q9GLM3 RPGR1_BOVIN 94.806 0.998342 0.987715 RPGRIP1 - X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 - Bos taurus (Bovine) - RPGRIP1 gene May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells. Taurus_UMD|evm.model.AC_000167.1.415 Q99880 H2B1L_HUMAN 97.590 0.97619 0.666667 H2BC13 - Histone H2B type 1-L - Homo sapiens (Human) - H2BC13 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000167.1.416 O77768 HNRPC_RABIT 94.788 0.99322 0.964052 HNRNPC - Heterogeneous nuclear ribonucleoprotein C - Oryctolagus cuniculus (Rabbit) - HNRNPC gene Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing. Taurus_UMD|evm.model.AC_000167.1.419 P0C7T8 TM253_HUMAN 84.925 0.965517 0.935484 TMEM253 - Transmembrane protein 253 - Homo sapiens (Human) - TMEM253 gene Taurus_UMD|evm.model.AC_000167.1.420 Q9P2Y4 ZN219_HUMAN 90.720 0.997211 0.993075 ZNF219 - Zinc finger protein 219 - Homo sapiens (Human) - ZNF219 gene Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity). Taurus_UMD|evm.model.AC_000167.1.421 Q8TER5 ARH40_HUMAN 89.093 0.998685 1.00132 ARHGEF40 - Rho guanine nucleotide exchange factor 40 - Homo sapiens (Human) - ARHGEF40 gene May act as a guanine nucleotide exchange factor (GEF). Taurus_UMD|evm.model.AC_000167.1.422 Q9H1E1 RNAS7_HUMAN 71.795 0.987261 1.00641 RNASE7 - Ribonuclease 7 precursor - Homo sapiens (Human) - RNASE7 gene Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% Taurus_UMD|evm.model.AC_000167.1.423 Q5GAM7 RNS13_MOUSE 70.588 0.987013 1.00654 Rnase13 - Probable inactive ribonuclease-like protein 13 precursor - Mus musculus (Mouse) - Rnase13 gene Does not exhibit any ribonuclease activity. Taurus_UMD|evm.model.AC_000167.1.424 Q3T077 TPPP2_BOVIN 100.000 0.988372 1.00585 TPPP2 - Tubulin polymerization-promoting protein family member 2 - Bos taurus (Bovine) - TPPP2 gene Probable regulator of microtubule dynamics required for sperm motility (By similarity). In contrast to other members of the family, has no microtubule bundling activity (By similarity). Taurus_UMD|evm.model.AC_000167.1.425 Q3ZBA8 NDRG2_BOVIN 87.675 0.993846 0.910364 NDRG2 - Protein NDRG2 - Bos taurus (Bovine) - NDRG2 gene Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity). Taurus_UMD|evm.model.AC_000167.1.426 Q9NP94 S39A2_HUMAN 78.317 0.993548 1.00324 SLC39A2 - Zinc transporter ZIP2 - Homo sapiens (Human) - SLC39A2 gene Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis. Taurus_UMD|evm.model.AC_000167.1.427 Q2TBP8 MET17_BOVIN 99.784 0.99568 1.00216 METTL17 - Methyltransferase-like protein 17, mitochondrial precursor - Bos taurus (Bovine) - METTL17 gene Probable S-adenosyl-L-methionine-dependent RNA methyltransferase required to stabilize the mitochondrial small ribosomal subunit (mt-SSU). Required for protein translation in mitochondria. Taurus_UMD|evm.model.AC_000167.1.428 P47784 RNAS2_PONPY 55.901 0.987421 0.987578 RNASE2 - Non-secretory ribonuclease precursor - Pongo pygmaeus (Bornean orangutan) - RNASE2 gene This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Possesses a wide variety of biological activities. Taurus_UMD|evm.model.AC_000167.1.429 Q8SQ08 RNAS1_SAISC 37.500 0.823944 0.910256 RNASE1 - Ribonuclease pancreatic precursor - Saimiri sciureus (Common squirrel monkey) - RNASE1 gene Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA (By similarity). Taurus_UMD|evm.model.AC_000167.1.430 P00669 RNS_BOVIN 100.000 0.986755 1.00667 SRN - Seminal ribonuclease precursor - Bos taurus (Bovine) - SRN gene This enzyme hydrolyzes both single- and double-stranded RNA. Taurus_UMD|evm.model.AC_000167.1.431 P39873 RNBR_BOVIN 100.000 0.988095 1.00599 BRN - Brain ribonuclease precursor - Bos taurus (Bovine) - BRN gene ribonuclease activity, RNA phosphodiester bond hydrolysis Taurus_UMD|evm.model.AC_000167.1.432 P15467 RNAS4_BOVIN 91.509 0.37234 2.36975 RNASE4 - Ribonuclease 4 - Bos taurus (Bovine) - RNASE4 gene This RNase has marked specificity towards the 3' side of uridine nucleotides. Taurus_UMD|evm.model.AC_000167.1.433 P10152 ANG1_BOVIN 72.603 0.973154 1.00676 ANG1 - Angiogenin-1 precursor - Bos taurus (Bovine) - ANG1 gene Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonuclease activity. Taurus_UMD|evm.model.AC_000167.1.434 Q9NYH9 UTP6_HUMAN 73.658 0.977011 1.0201 UTP6 - U3 small nucleolar RNA-associated protein 6 homolog - Homo sapiens (Human) - UTP6 gene Involved in nucleolar processing of pre-18S ribosomal RNA. Taurus_UMD|evm.model.AC_000167.1.435 Q9H1E1 RNAS7_HUMAN 68.590 0.91716 1.08333 RNASE7 - Ribonuclease 7 precursor - Homo sapiens (Human) - RNASE7 gene Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% Taurus_UMD|evm.model.AC_000167.1.436 Q28521 ROA1_MACMU 69.500 0.852273 0.55 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Macaca mulatta (Rhesus macaque) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins (By similarity). Taurus_UMD|evm.model.AC_000167.1.437 P61823 RNAS1_BOVIN 100.000 0.986755 1.00667 RNASE1 - Ribonuclease pancreatic precursor - Bos taurus (Bovine) - RNASE1 gene Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA. Taurus_UMD|evm.model.AC_000167.1.438 P08904 RNAS6_BOVIN 100.000 0.987097 1.00649 RNASE6 - Ribonuclease K6 precursor - Bos taurus (Bovine) - RNASE6 gene Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:3926759). Has potent antimicrobial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (By similarity). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (By similarity). Probably contributes to urinary tract sterility (By similarity). Bactericidal activity is independent of RNase activity (By similarity). Taurus_UMD|evm.model.AC_000167.1.439 P56851 EP3B_HUMAN 55.102 0.884146 1.11565 EDDM3B - Epididymal secretory protein E3-beta precursor - Homo sapiens (Human) - EDDM3B gene Possible function in sperm maturation. Taurus_UMD|evm.model.AC_000167.1.440 P15467 RNAS4_BOVIN 98.305 0.790541 1.2437 RNASE4 - Ribonuclease 4 - Bos taurus (Bovine) - RNASE4 gene This RNase has marked specificity towards the 3' side of uridine nucleotides. Taurus_UMD|evm.model.AC_000167.1.441 P10152 ANG1_BOVIN 99.324 0.986577 1.00676 ANG1 - Angiogenin-1 precursor - Bos taurus (Bovine) - ANG1 gene Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonuclease activity. Taurus_UMD|evm.model.AC_000167.1.442 P80929 ANG2_BOVIN 100.000 0.606965 1.63415 ANG2 - Angiogenin-2 - Bos taurus (Bovine) - ANG2 gene Binds tightly to placental ribonuclease inhibitor and has very low ribonuclease activity. Has potent angiogenic activity. Angiogenin induces vascularization of normal and malignant tissues. Abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Taurus_UMD|evm.model.AC_000167.1.443 Q8NH40 OR6S1_HUMAN 71.429 0.213178 0.779456 OR6S1 - Olfactory receptor 6S1 - Homo sapiens (Human) - OR6S1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000167.1.444 Q5GAN4 RNS12_HUMAN 67.347 0.75 1.30612 RNASE12 - Probable inactive ribonuclease-like protein 12 precursor - Homo sapiens (Human) - RNASE12 gene Does not exhibit any ribonuclease activity. Taurus_UMD|evm.model.AC_000167.1.445 Q7YRH1 RNAS9_CHLAE 47.059 0.737705 0.897059 RNASE9 - Inactive ribonuclease-like protein 9 precursor - Chlorocebus aethiops (Green monkey) - RNASE9 gene Does not exhibit any ribonuclease activity. Taurus_UMD|evm.model.AC_000167.1.446 Q7YRH1 RNAS9_CHLAE 41.912 0.63981 1.03431 RNASE9 - Inactive ribonuclease-like protein 9 precursor - Chlorocebus aethiops (Green monkey) - RNASE9 gene Does not exhibit any ribonuclease activity. Taurus_UMD|evm.model.AC_000167.1.447 Q70IB2 RNS10_BOVIN 100.000 0.990566 1.00474 RNASE10 - Inactive ribonuclease-like protein 10 precursor - Bos taurus (Bovine) - RNASE10 gene Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity). Taurus_UMD|evm.model.AC_000167.1.448 P55859 PNPH_BOVIN 100.000 0.993103 1.00346 PNP - Purine nucleoside phosphorylase - Bos taurus (Bovine) - PNP gene Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (By similarity). Taurus_UMD|evm.model.AC_000167.1.449 P55859 PNPH_BOVIN 87.565 0.932039 0.712803 PNP - Purine nucleoside phosphorylase - Bos taurus (Bovine) - PNP gene Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (By similarity). Taurus_UMD|evm.model.AC_000167.1.450 Q4R6W2 PP4P1_MACFA 99.648 0.992982 1.00352 PIP4P1 - Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase - Macaca fascicularis (Crab-eating macaque) - PIP4P1 gene Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (By similarity). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (By similarity). May play a role in the regulation of cellular cholesterol metabolism (By similarity). Taurus_UMD|evm.model.AC_000167.1.451 P23196 APEX1_BOVIN 99.686 0.99373 1.00314 APEX1 - DNA-(apurinic or apyrimidinic site) endonuclease - Bos taurus (Bovine) - APEX1 gene Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA (By similarity). Taurus_UMD|evm.model.AC_000167.1.452 Q0VCI1 OSGEP_BOVIN 100.000 0.994048 1.00299 OSGEP - Probable tRNA N6-adenosine threonylcarbamoyltransferase - Bos taurus (Bovine) - OSGEP gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. Taurus_UMD|evm.model.AC_000167.1.453 P59158 S12A3_MOUSE 48.077 0.206478 0.246507 Slc12a3 - Solute carrier family 12 member 3 - Mus musculus (Mouse) - Slc12a3 gene Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (By similarity). Receptor for the proinflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1 (PubMed:26099046). Taurus_UMD|evm.model.AC_000167.1.454 A6NCF5 KLH33_HUMAN 89.869 0.151567 6.58537 KLHL33 - Kelch-like protein 33 - Homo sapiens (Human) - KLHL33 gene Taurus_UMD|evm.model.AC_000167.1.455 Q9UGN5 PARP2_HUMAN 88.652 0.971581 0.965695 PARP2 - Poly [ADP-ribose] polymerase 2 - Homo sapiens (Human) - PARP2 gene Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:25043379, PubMed:27471034, PubMed:32028527, PubMed:32939087). Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379, PubMed:30321391). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:32939087). Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1 (PubMed:25043379). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP2 active site (PubMed:28190768, PubMed:32028527). PARP2 initiates the repair of double-strand DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:10364231, PubMed:32939087). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034). Taurus_UMD|evm.model.AC_000167.1.456 Q9NPC3 CIP1_HUMAN 95.307 0.992806 1.00361 CCNB1IP1 - E3 ubiquitin-protein ligase CCNB1IP1 - Homo sapiens (Human) - CCNB1IP1 gene Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. Taurus_UMD|evm.model.AC_000167.1.457 Q0P5H9 TTC5_BOVIN 100.000 0.995455 1 TTC5 - Tetratricopeptide repeat protein 5 - Bos taurus (Bovine) - TTC5 gene Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity). Taurus_UMD|evm.model.AC_000167.1.458 Q07537 GALT1_BOVIN 61.323 0.994334 0.631485 GALNT1 - Polypeptide N-acetylgalactosaminyltransferase 1 - Bos taurus (Bovine) - GALNT1 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. Taurus_UMD|evm.model.AC_000167.1.459 Q8NGC8 O11H7_HUMAN 65.957 0.973958 0.611465 OR11H7 - Olfactory receptor 11H7 - Homo sapiens (Human) - OR11H7 gene Odorant receptor. Activated by isovaleric acid. Taurus_UMD|evm.model.AC_000167.1.460 Q8NGC7 O11H6_HUMAN 64.423 0.953704 0.327273 OR11H6 - Olfactory receptor 11H6 - Homo sapiens (Human) - OR11H6 gene Odorant receptor. Taurus_UMD|evm.model.AC_000167.1.461 Q8NGC9 O11H4_HUMAN 61.497 0.738095 0.777778 OR11H4 - Olfactory receptor 11H4 - Homo sapiens (Human) - OR11H4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000167.1.462 A4IFF3 TTC9C_BOVIN 97.661 0.988372 1.00585 TTC9C - Tetratricopeptide repeat protein 9C - Bos taurus (Bovine) - TTC9C gene Taurus_UMD|evm.model.AC_000167.1.463 Q8NGC1 O11G2_HUMAN 65.686 0.765152 0.382609 OR11G2 - Olfactory receptor 11G2 - Homo sapiens (Human) - OR11G2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000167.1.464 Q8NGD0 OR4M1_HUMAN 93.333 0.992188 0.817891 OR4M1 - Olfactory receptor 4M1 - Homo sapiens (Human) - OR4M1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000167.1.465 Q8NGD2 OR4K2_HUMAN 70.886 0.957317 0.522293 OR4K2 - Olfactory receptor 4K2 - Homo sapiens (Human) - OR4K2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000167.1.466 Q8NH41 OR4KF_HUMAN 69.822 0.982456 0.491379 OR4K15 - Olfactory receptor 4K15 - Homo sapiens (Human) - OR4K15 gene Odorant receptor. Taurus_UMD|evm.model.AC_000167.1.467 Q8NH43 OR4L1_HUMAN 79.121 0.473684 0.608974 OR4L1 - Olfactory receptor 4L1 - Homo sapiens (Human) - OR4L1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000167.1.468 Q8NH43 OR4L1_HUMAN 80.263 0.980519 0.49359 OR4L1 - Olfactory receptor 4L1 - Homo sapiens (Human) - OR4L1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000167.1.470 Q6IEY1 OR4F3_HUMAN 85.714 0.989796 0.314103 OR4F3 - Olfactory receptor 4F3/4F16/4F29 - Homo sapiens (Human) - OR4F3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000167.1.471 Q8NGB9 OR4F6_HUMAN 75.884 0.990415 1.00321 OR4F6 - Olfactory receptor 4F6 - Homo sapiens (Human) - OR4F6 gene Odorant receptor. Taurus_UMD|evm.model.AC_000167.1.472 Q6IEY1 OR4F3_HUMAN 76.963 0.883721 0.689103 OR4F3 - Olfactory receptor 4F3/4F16/4F29 - Homo sapiens (Human) - OR4F3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000167.1.473 P62752 RL23A_RAT 93.519 0.768116 0.884615 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000167.1.474 Q643R3 LPCT4_HUMAN 91.337 0.99619 1.00191 LPCAT4 - Lysophospholipid acyltransferase LPCAT4 - Homo sapiens (Human) - LPCAT4 gene Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors. Taurus_UMD|evm.model.AC_000167.1.475 Q86Y26 NUTM1_HUMAN 68.003 0.998238 1.00265 NUTM1 - NUT family member 1 - Homo sapiens (Human) - NUTM1 gene Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. Taurus_UMD|evm.model.AC_000167.1.476 Q9CQS2 NOP10_MOUSE 95.312 0.969231 1.01562 Nop10 - H/ACA ribonucleoprotein complex subunit 3 - Mus musculus (Mouse) - Nop10 gene Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). Taurus_UMD|evm.model.AC_000167.1.477 Q9UHW9 S12A6_HUMAN 98.870 0.911905 1.09565 SLC12A6 - Solute carrier family 12 member 6 - Homo sapiens (Human) - SLC12A6 gene Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells. Taurus_UMD|evm.model.AC_000167.1.478 Q3T0K8 EMC4_BOVIN 100.000 0.98913 1.00546 EMC4 - ER membrane protein complex subunit 4 - Bos taurus (Bovine) - EMC4 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Taurus_UMD|evm.model.AC_000167.1.479 A5PJA8 EMC7_BOVIN 99.585 0.991736 1.00415 EMC7 - ER membrane protein complex subunit 7 precursor - Bos taurus (Bovine) - EMC7 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Taurus_UMD|evm.model.AC_000167.1.480 P08912 ACM5_HUMAN 90.414 0.996248 1.00188 CHRM5 - Muscarinic acetylcholine receptor M5 - Homo sapiens (Human) - CHRM5 gene The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Taurus_UMD|evm.model.AC_000167.1.481 Q9NQS1 AVEN_HUMAN 77.544 0.797753 0.983425 AVEN - Cell death regulator Aven - Homo sapiens (Human) - AVEN gene Protects against apoptosis mediated by Apaf-1. Taurus_UMD|evm.model.AC_000167.1.482 Q15413 RYR3_HUMAN 94.595 0.998053 0.949076 RYR3 - Ryanodine receptor 3 - Homo sapiens (Human) - RYR3 gene Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling. Taurus_UMD|evm.model.AC_000167.1.483 Q32L59 TMC5B_BOVIN 87.179 0.993506 0.877493 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Taurus_UMD|evm.model.AC_000167.1.485 Q8WNY1 GREM1_MACMU 100.000 0.933673 1.06522 GREM1 - Gremlin-1 precursor - Macaca mulatta (Rhesus macaque) - GREM1 gene Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity). Taurus_UMD|evm.model.AC_000167.1.486 P01165 7B2_PIG 97.596 0.971831 1.02899 SCG5 - Neuroendocrine protein 7B2 precursor - Sus scrofa (Pig) - SCG5 gene Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. Taurus_UMD|evm.model.AC_000167.1.487 Q3KRB8 RHGBB_HUMAN 87.727 0.213867 3.83521 ARHGAP11B - Inactive Rho GTPase-activating protein 11B precursor - Homo sapiens (Human) - ARHGAP11B gene Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex (PubMed:25721503, PubMed:27957544, PubMed:30484771, PubMed:32554627). Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion (PubMed:25721503). Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation (PubMed:31883789). Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development (PubMed:25721503, PubMed:27957544). Taurus_UMD|evm.model.AC_000167.1.488 Q866T7 CXD2_BOVIN 100.000 0.993789 1.00312 GJD2 - Gap junction delta-2 protein - Bos taurus (Bovine) - GJD2 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Taurus_UMD|evm.model.AC_000167.1.489 Q6P640 ACTC_XENTR 100.000 0.994709 1.00265 actc1 - Actin, alpha cardiac muscle 1 precursor - Xenopus tropicalis (Western clawed frog) - actc1 gene Actins are highly conserved proteins that are involved in various types of cell motility. Taurus_UMD|evm.model.AC_000167.1.490 O60306 AQR_HUMAN 90.581 0.998648 0.99596 AQR - RNA helicase aquarius - Homo sapiens (Human) - AQR gene Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28502770, PubMed:28076346). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396). Taurus_UMD|evm.model.AC_000167.1.491 Q6IQ21 ZN770_HUMAN 80.202 0.997097 0.997106 ZNF770 - Zinc finger protein 770 - Homo sapiens (Human) - ZNF770 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000167.1.492 Q2HJF5 DPH6_BOVIN 100.000 0.992537 1.00375 DPH6 - Diphthine--ammonia ligase - Bos taurus (Bovine) - DPH6 gene Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (By similarity). Taurus_UMD|evm.model.AC_000167.1.493 Q5E9S8 CDIN1_BOVIN 100.000 0.987952 0.590747 CDIN1 - CDAN1-interacting nuclease 1 - Bos taurus (Bovine) - CDIN1 gene Plays a role in erythroid cell differentiation. Taurus_UMD|evm.model.AC_000167.1.494 O14770 MEIS2_HUMAN 99.371 0.995816 1.0021 MEIS2 - Homeobox protein Meis2 - Homo sapiens (Human) - MEIS2 gene Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription. Taurus_UMD|evm.model.AC_000167.1.495 Q9D9D5 TMC5A_MOUSE 75.578 0.912387 1.09241 Tmco5a - Transmembrane and coiled-coil domain-containing protein 5A - Mus musculus (Mouse) - Tmco5a gene Taurus_UMD|evm.model.AC_000167.1.497 Q7Z699 SPRE1_HUMAN 92.809 0.995495 1 SPRED1 - Sprouty-related, EVH1 domain-containing protein 1 - Homo sapiens (Human) - SPRED1 gene Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). Taurus_UMD|evm.model.AC_000167.1.498 Q52LJ0 FA98B_HUMAN 94.545 0.84359 0.900693 FAM98B - Protein FAM98B - Homo sapiens (Human) - FAM98B gene Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436). Promotes colorectal cancer cell malignancy (PubMed:28040436). Taurus_UMD|evm.model.AC_000167.1.499 O95267 GRP1_HUMAN 93.408 0.997516 1.01004 RASGRP1 - RAS guanyl-releasing protein 1 - Homo sapiens (Human) - RASGRP1 gene Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768, PubMed:27776107, PubMed:29155103). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994, PubMed:27776107, PubMed:29155103). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types (PubMed:12845332). Taurus_UMD|evm.model.AC_000167.1.502 Q28178 TSP1_BOVIN 99.658 0.973356 1.0265 THBS1 - Thrombospondin-1 precursor - Bos taurus (Bovine) - THBS1 gene Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties (By similarity). May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). Taurus_UMD|evm.model.AC_000167.1.503 Q8NA03 FSIP1_HUMAN 74.570 0.994863 1.00516 FSIP1 - Fibrous sheath-interacting protein 1 - Homo sapiens (Human) - FSIP1 gene Taurus_UMD|evm.model.AC_000167.1.504 Q14439 GP176_HUMAN 92.621 0.996124 1.00194 GPR176 - G-protein coupled receptor 176 - Homo sapiens (Human) - GPR176 gene Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production. Taurus_UMD|evm.model.AC_000167.1.505 Q9P2K8 E2AK4_HUMAN 93.537 0.991515 1.00061 EIF2AK4 - eIF-2-alpha kinase GCN2 - Homo sapiens (Human) - EIF2AK4 gene Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity). Binds uncharged tRNAs (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). Taurus_UMD|evm.model.AC_000167.1.506 A6QQL9 SRP14_BOVIN 100.000 0.981982 1.00909 SRP14 - Signal recognition particle 14 kDa protein - Bos taurus (Bovine) - SRP14 gene Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity). Taurus_UMD|evm.model.AC_000167.1.507 Q96LC9 BMF_HUMAN 91.848 0.831818 1.19565 BMF - Bcl-2-modifying factor - Homo sapiens (Human) - BMF gene May play a role in apoptosis. Isoform 1 seems to be the main initiator. Taurus_UMD|evm.model.AC_000167.1.508 O60566 BUB1B_HUMAN 88.677 0.98683 1.01238 BUB1B - Mitotic checkpoint serine/threonine-protein kinase BUB1 beta - Homo sapiens (Human) - BUB1B gene Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. Taurus_UMD|evm.model.AC_000167.1.509 Q5R8Z4 PAK6_PONAB 93.539 0.997067 1.00147 PAK6 - Serine/threonine-protein kinase PAK 6 - Pongo abelii (Sumatran orangutan) - PAK6 gene Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity). Taurus_UMD|evm.model.AC_000167.1.510 C9JTQ0 ANR63_HUMAN 93.979 0.994778 1.00789 ANKRD63 - Ankyrin repeat domain-containing protein 63 - Homo sapiens (Human) - ANKRD63 gene Taurus_UMD|evm.model.AC_000167.1.511 Q00722 PLCB2_HUMAN 88.047 0.998289 0.986498 PLCB2 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 - Homo sapiens (Human) - PLCB2 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Taurus_UMD|evm.model.AC_000167.1.512 P0DMQ5 INAM2_HUMAN 91.503 0.986928 1 INAFM2 - Putative transmembrane protein INAFM2 - Homo sapiens (Human) - INAFM2 gene calcium channel regulator activity Taurus_UMD|evm.model.AC_000167.1.514 Q5RCJ6 CCD9B_PONAB 70.312 0.996071 0.951402 CCDC9B - Coiled-coil domain-containing protein 9B - Pongo abelii (Sumatran orangutan) - CCDC9B gene Taurus_UMD|evm.model.AC_000167.1.516 A7MBM2 DISP2_HUMAN 88.439 0.985043 1.00214 DISP2 - Protein dispatched homolog 2 - Homo sapiens (Human) - DISP2 gene plasma membrane, smoothened signaling pathway Taurus_UMD|evm.model.AC_000167.1.517 Q9Y448 SKAP_HUMAN 82.427 0.991525 0.746835 KNSTRN - Small kinetochore-associated protein - Homo sapiens (Human) - KNSTRN gene Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). Taurus_UMD|evm.model.AC_000167.1.518 Q3SZI8 IVD_BOVIN 100.000 0.995316 1.00235 IVD - Isovaleryl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - IVD gene Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA. Taurus_UMD|evm.model.AC_000167.1.519 Q8TBE0 BAHD1_HUMAN 91.165 0.997426 0.996154 BAHD1 - Bromo adjacent homology domain-containing 1 protein - Homo sapiens (Human) - BAHD1 gene Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. Taurus_UMD|evm.model.AC_000167.1.520 Q8NCH0 CHSTE_HUMAN 93.617 0.994695 1.00266 CHST14 - Carbohydrate sulfotransferase 14 - Homo sapiens (Human) - CHST14 gene Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development. Taurus_UMD|evm.model.AC_000167.1.521 Q9BV29 CCD32_HUMAN 87.151 0.723577 1.32973 CCDC32 - Coiled-coil domain-containing protein 32 - Homo sapiens (Human) - CCDC32 gene Taurus_UMD|evm.model.AC_000167.1.522 Q8IZ73 RUSD2_HUMAN 83.559 0.99422 0.952294 RPUSD2 - RNA pseudouridylate synthase domain-containing protein 2 - Homo sapiens (Human) - RPUSD2 gene pseudouridine synthase activity, RNA binding, enzyme-directed rRNA pseudouridine synthesis, mRNA pseudouridine synthesis Taurus_UMD|evm.model.AC_000167.1.523 Q8NG31 KNL1_HUMAN 69.571 0.999146 1 KNL1 - Kinetochore scaffold 1 - Homo sapiens (Human) - KNL1 gene Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. Taurus_UMD|evm.model.AC_000167.1.524 Q2KJ94 RAD51_BOVIN 100.000 0.994118 1.00295 RAD51 - DNA repair protein RAD51 homolog 1 - Bos taurus (Bovine) - RAD51 gene Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair. Taurus_UMD|evm.model.AC_000167.1.525 Q1JQC5 RMD3_BOVIN 100.000 0.995763 1.00212 RMDN3 - Regulator of microtubule dynamics protein 3 - Bos taurus (Bovine) - RMDN3 gene Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity). Taurus_UMD|evm.model.AC_000167.1.526 Q32L41 GFRP_BOVIN 100.000 0.976471 1.0119 GCHFR - GTP cyclohydrolase 1 feedback regulatory protein - Bos taurus (Bovine) - GCHFR gene Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine (By similarity). Taurus_UMD|evm.model.AC_000167.1.527 Q2KI83 DJC17_BOVIN 100.000 0.993443 1.00329 DNAJC17 - DnaJ homolog subfamily C member 17 - Bos taurus (Bovine) - DNAJC17 gene May negatively affect PAX8-induced thyroglobulin/TG transcription. Taurus_UMD|evm.model.AC_000167.1.528 Q96K21 ANCHR_HUMAN 79.472 0.916442 0.787686 ZFYVE19 - Abscission/NoCut checkpoint regulator - Homo sapiens (Human) - ZFYVE19 gene Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. Taurus_UMD|evm.model.AC_000167.1.529 Q9NXH3 PP14D_HUMAN 87.586 0.655963 1.50345 PPP1R14D - Protein phosphatase 1 regulatory subunit 14D - Homo sapiens (Human) - PPP1R14D gene Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Taurus_UMD|evm.model.AC_000167.1.530 O43278 SPIT1_HUMAN 78.450 0.996109 0.971645 SPINT1 - Kunitz-type protease inhibitor 1 precursor - Homo sapiens (Human) - SPINT1 gene Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). Taurus_UMD|evm.model.AC_000167.1.531 Q17QI8 RHOV_BOVIN 100.000 0.800948 0.894068 Rhov - Rho-related GTP-binding protein RhoV - Bos taurus (Bovine) - Rhov gene Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway. Taurus_UMD|evm.model.AC_000167.1.532 Q9P253 VPS18_HUMAN 97.122 0.997947 1.00103 VPS18 - Vacuolar protein sorting-associated protein 18 homolog - Homo sapiens (Human) - VPS18 gene Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity). Taurus_UMD|evm.model.AC_000167.1.533 Q9NR61 DLL4_HUMAN 92.398 0.749726 1.32993 DLL4 - Delta-like protein 4 precursor - Homo sapiens (Human) - DLL4 gene Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344). Taurus_UMD|evm.model.AC_000167.1.534 Q9BUX1 CHAC1_HUMAN 92.342 0.990909 0.990991 CHAC1 - Glutathione-specific gamma-glutamylcyclotransferase 1 - Homo sapiens (Human) - CHAC1 gene Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366). Taurus_UMD|evm.model.AC_000167.1.535 Q9ULG1 INO80_HUMAN 97.126 0.998724 1.00707 INO80 - Chromatin-remodeling ATPase INO80 - Homo sapiens (Human) - INO80 gene ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820). Taurus_UMD|evm.model.AC_000167.1.536 Q5I0H3 SUMO1_RAT 96.040 0.694444 1.42574 Sumo1 - Small ubiquitin-related modifier 1 precursor - Rattus norvegicus (Rat) - Sumo1 gene Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3. Taurus_UMD|evm.model.AC_000167.1.537 Q8NHP7 EXD1_HUMAN 80.198 0.874126 1.11284 EXD1 - piRNA biogenesis protein EXD1 - Homo sapiens (Human) - EXD1 gene RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity). Taurus_UMD|evm.model.AC_000167.1.538 Q3SYS6 CHP1_BOVIN 100.000 0.989796 1.00513 CHP1 - Calcineurin B homologous protein 1 - Bos taurus (Bovine) - CHP1 gene Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000167.1.539 O43482 MS18B_HUMAN 82.096 0.991304 1.00437 OIP5 - Protein Mis18-beta - Homo sapiens (Human) - OIP5 gene Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. Taurus_UMD|evm.model.AC_000167.1.540 Q2YDJ0 NUSAP_BOVIN 100.000 0.995708 1.00215 NUSAP1 - Nucleolar and spindle-associated protein 1 - Bos taurus (Bovine) - NUSAP1 gene Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them (By similarity). Taurus_UMD|evm.model.AC_000167.1.541 Q0MQ84 CIA30_PANTR 82.927 0.993921 1.00612 NDUFAF1 - Complex I intermediate-associated protein 30, mitochondrial precursor - Pan troglodytes (Chimpanzee) - NDUFAF1 gene Chaperone protein involved in early stages of the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Taurus_UMD|evm.model.AC_000167.1.542 Q92541 RTF1_HUMAN 98.319 0.997203 1.00704 RTF1 - RNA polymerase-associated protein RTF1 homolog - Homo sapiens (Human) - RTF1 gene Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). Taurus_UMD|evm.model.AC_000167.1.543 P23677 IP3KA_HUMAN 96.095 0.995671 1.00217 ITPKA - Inositol-trisphosphate 3-kinase A - Homo sapiens (Human) - ITPKA gene cytoplasm, cytosol, nucleus, inositol hexakisphosphate kinase activity, inositol-1,4,5-trisphosphate 3-kinase activity, kinase activity, inositol phosphate biosynthetic process, inositol phosphate metabolic process, phosphatidylinositol phosphorylation, signal transduction Taurus_UMD|evm.model.AC_000167.1.545 A0JN53 RPAP1_BOVIN 100.000 0.998567 1.00072 RPAP1 - RNA polymerase II-associated protein 1 - Bos taurus (Bovine) - RPAP1 gene Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity). Taurus_UMD|evm.model.AC_000167.1.546 Q06418 TYRO3_HUMAN 92.865 0.959551 1 TYRO3 - Tyrosine-protein kinase receptor TYRO3 precursor - Homo sapiens (Human) - TYRO3 gene Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Taurus_UMD|evm.model.AC_000167.1.547 A6QLH6 SCYL1_BOVIN 53.741 0.789474 0.164808 SCYL1 - N-terminal kinase-like protein - Bos taurus (Bovine) - SCYL1 gene Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro. Taurus_UMD|evm.model.AC_000167.1.548 Q8IWI9 MGAP_HUMAN 87.412 0.999358 1.01631 MGA - MAX gene-associated protein - Homo sapiens (Human) - MGA gene Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity). Taurus_UMD|evm.model.AC_000167.1.549 O60336 MABP1_HUMAN 89.637 0.998007 0.994055 MAPKBP1 - Mitogen-activated protein kinase-binding protein 1 - Homo sapiens (Human) - MAPKBP1 gene Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). Taurus_UMD|evm.model.AC_000167.1.550 P0C870 JMJD7_HUMAN 93.291 0.285453 3.45886 JMJD7 - Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 - Homo sapiens (Human) - JMJD7 gene Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase (PubMed:28847961, PubMed:29915238). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4 (PubMed:28847961). After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961). Additionally, may play a role in protein biosynthesis by modifying the translation machinery (PubMed:29915238). Acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA) (PubMed:29915238). Taurus_UMD|evm.model.AC_000167.1.551 Q9NRC6 SPTN5_HUMAN 68.595 0.741384 1.03457 SPTBN5 - Spectrin beta chain, non-erythrocytic 5 - Homo sapiens (Human) - SPTBN5 gene cytoplasm, cytosol, membrane, photoreceptor connecting cilium, photoreceptor disc membrane, spectrin, actin binding, dynactin binding, dynein intermediate chain binding, identical protein binding Taurus_UMD|evm.model.AC_000167.1.552 Q9H223 EHD4_HUMAN 94.640 0.996303 1 EHD4 - EH domain-containing protein 4 - Homo sapiens (Human) - EHD4 gene ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport. Taurus_UMD|evm.model.AC_000167.1.553 Q3MJ16 PA24E_HUMAN 79.484 0.965217 0.927419 PLA2G4E - Cytosolic phospholipase A2 epsilon - Homo sapiens (Human) - PLA2G4E gene Calcium-dependent N-acyltransferase involved in the biosynthesis of N-acyl ethanolamines (NAEs) in the brain (PubMed:29447909). Transfers the sn-1 fatty acyl chain of phosphatidylcholine (fatty acyl donor) to the amine group of phosphatidylethanolamine (fatty acyl acceptor) to generate N-acyl phosphatidylethanolamine (NAPE). Similarly can use plasmenylethanolamine as a fatty acyl acceptor to form N-acyl plasmenylethanolamine (N-Acyl-PlsEt). Both NAPE and N-Acyl-PlsEt can serve as precursors of bioactive NAEs like N-arachidonoyl phosphatidylethanolamine also called anandamide (PubMed:29447909, PubMed:30517655). Has weak phospholipase A2 and lysophospholipase activities (By similarity). Regulates intracellular membrane trafficking that requires modulation of membrane curvature as it occurs by enrichment in lysophospholipids. Promotes tubule formation involved in clathrin-independent endocytotic trafficking and cargo recycling (By similarity). Taurus_UMD|evm.model.AC_000167.1.554 Q86XP0 PA24D_HUMAN 79.615 0.992298 0.952323 PLA2G4D - Cytosolic phospholipase A2 delta - Homo sapiens (Human) - PLA2G4D gene Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:14709560). Has a preference for linoleic acid at the sn-2 position (PubMed:14709560). Taurus_UMD|evm.model.AC_000167.1.555 Q68DD2 PA24F_HUMAN 82.332 0.997636 0.996466 PLA2G4F - Cytosolic phospholipase A2 zeta - Homo sapiens (Human) - PLA2G4F gene Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:29158256). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:29158256). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis (PubMed:29158256). In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs) (PubMed:29158256). Taurus_UMD|evm.model.AC_000167.1.556 Q96JC1 VPS39_HUMAN 97.178 0.997717 0.988713 VPS39 - Vam6/Vps39-like protein - Homo sapiens (Human) - VPS39 gene Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. Taurus_UMD|evm.model.AC_000167.1.557 Q8NBN3 TM87A_HUMAN 91.449 0.996516 1.03423 TMEM87A - Transmembrane protein 87A precursor - Homo sapiens (Human) - TMEM87A gene May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). Taurus_UMD|evm.model.AC_000167.1.558 Q9BE70 GANC_MACFA 87.240 0.838251 1.18986 GANC - Neutral alpha-glucosidase C - Macaca fascicularis (Crab-eating macaque) - GANC gene Has alpha-glucosidase activity. Taurus_UMD|evm.model.AC_000167.1.559 P51186 CAN3_BOVIN 99.878 0.99757 1.00122 CAPN3 - Calpain-3 - Bos taurus (Bovine) - CAPN3 gene Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53. Taurus_UMD|evm.model.AC_000167.1.560 Q9H2Y7 ZN106_HUMAN 87.908 0.978992 1.01115 ZNF106 - Zinc finger protein 106 - Homo sapiens (Human) - ZNF106 gene RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. Taurus_UMD|evm.model.AC_000167.1.561 O09044 SNP23_MOUSE 89.100 0.990566 1.00952 Snap23 - Synaptosomal-associated protein 23 - Mus musculus (Mouse) - Snap23 gene Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. Taurus_UMD|evm.model.AC_000167.1.562 Q5FVI3 LRC57_RAT 95.397 0.991667 1.00418 Lrrc57 - Leucine-rich repeat-containing protein 57 - Rattus norvegicus (Rat) - Lrrc57 gene Taurus_UMD|evm.model.AC_000167.1.563 Q9NVX0 HAUS2_HUMAN 85.532 0.991525 1.00426 HAUS2 - HAUS augmin-like complex subunit 2 - Homo sapiens (Human) - HAUS2 gene Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Taurus_UMD|evm.model.AC_000167.1.564 Q9P2P6 STAR9_HUMAN 90.000 0.0179668 0.935532 STARD9 - StAR-related lipid transfer protein 9 - Homo sapiens (Human) - STARD9 gene Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM). Taurus_UMD|evm.model.AC_000167.1.565 Q8IWY9 CDAN1_HUMAN 89.024 0.998375 1.00326 CDAN1 - Codanin-1 - Homo sapiens (Human) - CDAN1 gene May act as a negative regulator of ASF1 in chromatin assembly. Taurus_UMD|evm.model.AC_000167.1.566 Q6IQ55 TTBK2_HUMAN 91.559 0.998392 1 TTBK2 - Tau-tubulin kinase 2 - Homo sapiens (Human) - TTBK2 gene Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. Taurus_UMD|evm.model.AC_000167.1.567 Q8IWV7 UBR1_HUMAN 94.067 0.99886 1.00286 UBR1 - E3 ubiquitin-protein ligase UBR1 - Homo sapiens (Human) - UBR1 gene E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Taurus_UMD|evm.model.AC_000167.1.568 Q0P6H9 TMM62_HUMAN 83.826 0.996894 1.00156 TMEM62 - Transmembrane protein 62 - Homo sapiens (Human) - TMEM62 gene Taurus_UMD|evm.model.AC_000167.1.569 Q2KIZ9 CCDB1_BOVIN 99.721 0.994429 1.00279 CCNDBP1 - Cyclin-D1-binding protein 1 - Bos taurus (Bovine) - CCNDBP1 gene May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription (By similarity). Taurus_UMD|evm.model.AC_000167.1.570 O46510 EPB42_BOVIN 100.000 0.231008 0.938865 EPB42 - Protein 4.2 - Bos taurus (Bovine) - EPB42 gene Probably plays an important role in the regulation of erythrocyte shape and mechanical properties. Taurus_UMD|evm.model.AC_000167.1.571 Q5R8Z6 MCFD2_PONAB 94.253 0.817308 0.712329 MCFD2 - Multiple coagulation factor deficiency protein 2 homolog precursor - Pongo abelii (Sumatran orangutan) - MCFD2 gene The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Taurus_UMD|evm.model.AC_000167.1.572 Q3SYR7 RL9_BOVIN 81.250 0.987578 0.838542 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000167.1.573 Q5RBN9 TAD2B_PONAB 60.377 0.657895 0.180952 TADA2B - Transcriptional adapter 2-beta - Pongo abelii (Sumatran orangutan) - TADA2B gene Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. Taurus_UMD|evm.model.AC_000167.1.574 P20290 BTF3_HUMAN 94.737 0.965517 0.281553 BTF3 - Transcription factor BTF3 - Homo sapiens (Human) - BTF3 gene When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. Taurus_UMD|evm.model.AC_000167.1.575 Q2TBW8 RL10L_BOVIN 100.000 0.990698 1.00467 RPL10L - 60S ribosomal protein L10-like - Bos taurus (Bovine) - RPL10L gene cytosolic large ribosomal subunit, structural constituent of ribosome, ribosomal large subunit assembly Taurus_UMD|evm.model.AC_000167.1.576 Q9GMT4 MDGA2_MACFA 98.214 0.71246 0.694013 MDGA2 - MAM domain-containing glycosylphosphatidylinositol anchor protein 2 precursor - Macaca fascicularis (Crab-eating macaque) - MDGA2 gene May be involved in cell-cell interactions. Taurus_UMD|evm.model.AC_000167.1.577 P60756 MDGA2_RAT 98.667 0.801609 0.393045 Mdga2 - MAM domain-containing glycosylphosphatidylinositol anchor protein 2 precursor - Rattus norvegicus (Rat) - Mdga2 gene May be involved in cell-cell interactions. Taurus_UMD|evm.model.AC_000167.1.578 Q7Z553 MDGA2_HUMAN 98.492 0.785714 0.263598 MDGA2 - MAM domain-containing glycosylphosphatidylinositol anchor protein 2 precursor - Homo sapiens (Human) - MDGA2 gene May be involved in cell-cell interactions. Taurus_UMD|evm.model.AC_000167.1.581 P43362 MAGA9_HUMAN 51.643 0.8 0.84127 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000167.1.582 P52701 MSH6_HUMAN 64.583 0.27439 0.120588 MSH6 - DNA mismatch repair protein Msh6 - Homo sapiens (Human) - MSH6 gene Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. Taurus_UMD|evm.model.AC_000167.1.583 P62275 RS29_RAT 97.059 0.3 1.96429 Rps29 - 40S ribosomal protein S29 - Rattus norvegicus (Rat) - Rps29 gene cytosolic small ribosomal subunit, polysomal ribosome, structural constituent of ribosome, zinc ion binding, cytoplasmic translation, positive regulation of apoptotic process Taurus_UMD|evm.model.AC_000167.1.584 Q96L50 LLR1_HUMAN 87.736 0.995294 1.02657 LRR1 - Leucine-rich repeat protein 1 - Homo sapiens (Human) - LRR1 gene May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000167.1.585 P83883 RL36A_RAT 100.000 0.981308 1.00943 Rpl36a - 60S ribosomal protein L36a - Rattus norvegicus (Rat) - Rpl36a gene cytosolic large ribosomal subunit, nucleus, response to organic substance, response to retinoic acid Taurus_UMD|evm.model.AC_000167.1.586 O19071 MGAT2_PIG 93.274 0.995526 1.00224 MGAT2 - Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase - Sus scrofa (Pig) - MGAT2 gene Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans. Taurus_UMD|evm.model.AC_000167.1.587 Q0VC73 KTU_BOVIN 100.000 0.99759 1.00121 DNAAF2 - Protein kintoun - Bos taurus (Bovine) - DNAAF2 gene Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. Taurus_UMD|evm.model.AC_000167.1.588 A7YWS7 DPOE2_BOVIN 98.124 0.996255 1.01328 POLE2 - DNA polymerase epsilon subunit 2 - Bos taurus (Bovine) - POLE2 gene Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Taurus_UMD|evm.model.AC_000167.1.589 Q8N7A1 KLDC1_HUMAN 94.335 0.995086 1.00246 KLHDC1 - Kelch domain-containing protein 1 - Homo sapiens (Human) - KLHDC1 gene cytosol Taurus_UMD|evm.model.AC_000167.1.590 Q5E9A7 KLDC2_BOVIN 100.000 0.995086 1.00246 KLHDC2 - Kelch domain-containing protein 2 - Bos taurus (Bovine) - KLHDC2 gene Represses CREB3-mediated transcription by interfering with CREB3-DNA binding. Taurus_UMD|evm.model.AC_000167.1.591 O60524 NEMF_HUMAN 93.321 0.998145 1.00186 NEMF - Nuclear export mediator factor NEMF - Homo sapiens (Human) - NEMF gene Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875). Taurus_UMD|evm.model.AC_000167.1.592 P62332 ARF6_RAT 100.000 0.988636 1.00571 Arf6 - ADP-ribosylation factor 6 - Rattus norvegicus (Rat) - Arf6 gene GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:26446845). Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:16672654). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early endosomes (PubMed:26446845). Taurus_UMD|evm.model.AC_000167.1.593 Q53VB8 FRIL_CANLF 65.476 0.902174 0.525714 FTL - Ferritin light chain - Canis lupus familiaris (Dog) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000167.1.594 Q9H867 MT21D_HUMAN 93.778 0.89243 1.09607 VCPKMT - Protein-lysine methyltransferase METTL21D - Homo sapiens (Human) - VCPKMT gene Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity. Taurus_UMD|evm.model.AC_000167.1.595 Q07890 SOS2_HUMAN 86.343 0.994382 0.935435 SOS2 - Son of sevenless homolog 2 - Homo sapiens (Human) - SOS2 gene Promotes the exchange of Ras-bound GDP by GTP. Taurus_UMD|evm.model.AC_000167.1.596 A7MBI3 L2HDH_BOVIN 100.000 0.99569 1.00216 L2HGDH - L-2-hydroxyglutarate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - L2HGDH gene mitochondrion, (S)-2-hydroxy-acid oxidase activity, 2-hydroxyglutarate dehydrogenase activity Taurus_UMD|evm.model.AC_000167.1.597 P22027 ATP5S_BOVIN 100.000 0.99005 1.005 DMAC2L - ATP synthase subunit s, mitochondrial precursor - Bos taurus (Bovine) - DMAC2L gene Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway. Taurus_UMD|evm.model.AC_000167.1.598 Q8CEQ0 CDKL1_MOUSE 91.193 0.994334 1.00284 Cdkl1 - Cyclin-dependent kinase-like 1 - Mus musculus (Mouse) - Cdkl1 gene ciliary transition zone, intracellular membrane-bounded organelle, nucleoplasm, nucleus, cyclin-dependent protein serine/threonine kinase activity, protein phosphorylation, regulation of cilium assembly Taurus_UMD|evm.model.AC_000167.1.600 Q9Y4K4 M4K5_HUMAN 95.260 0.997688 1.02246 MAP4K5 - Mitogen-activated protein kinase kinase kinase kinase 5 - Homo sapiens (Human) - MAP4K5 gene May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Taurus_UMD|evm.model.AC_000167.1.601 Q58D72 ATLA1_BOVIN 96.325 0.994 0.896057 ATL1 - Atlastin-1 - Bos taurus (Bovine) - ATL1 gene GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. Taurus_UMD|evm.model.AC_000167.1.602 Q9H4B6 SAV1_HUMAN 96.354 0.994805 1.00522 SAV1 - Protein salvador homolog 1 - Homo sapiens (Human) - SAV1 gene Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Taurus_UMD|evm.model.AC_000167.1.603 Q8N4C6 NIN_HUMAN 86.329 0.948624 1.04306 NIN - Ninein - Homo sapiens (Human) - NIN gene Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). Taurus_UMD|evm.model.AC_000167.1.605 Q7Z5M8 AB12B_HUMAN 84.320 0.98827 0.941989 ABHD12B - Protein ABHD12B - Homo sapiens (Human) - ABHD12B gene endoplasmic reticulum membrane, membrane, acylglycerol lipase activity, lysophospholipase activity, palmitoyl-(protein) hydrolase activity, monoacylglycerol catabolic process, phosphatidylserine catabolic process Taurus_UMD|evm.model.AC_000167.1.606 Q0VCM4 PYGL_BOVIN 100.000 0.997653 1.00118 PYGL - Glycogen phosphorylase, liver form - Bos taurus (Bovine) - PYGL gene Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). Taurus_UMD|evm.model.AC_000167.1.607 Q29RQ5 TRIM9_BOVIN 100.000 0.997187 1.00141 TRIM9 - E3 ubiquitin-protein ligase TRIM9 - Bos taurus (Bovine) - TRIM9 gene E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. Taurus_UMD|evm.model.AC_000167.1.608 Q0Z7W6 TMX1_BOVIN 100.000 0.992832 1.0036 TMX1 - Thioredoxin-related transmembrane protein 1 precursor - Bos taurus (Bovine) - TMX1 gene May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Taurus_UMD|evm.model.AC_000167.1.609 Q96NE9 FRMD6_HUMAN 98.553 0.99679 1.00161 FRMD6 - FERM domain-containing protein 6 - Homo sapiens (Human) - FRMD6 gene cytoskeleton, actomyosin structure organization Taurus_UMD|evm.model.AC_000167.1.610 Q5R7U4 GBG2_PONAB 100.000 0.972222 1.01408 GNG2 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor - Pongo abelii (Sumatran orangutan) - GNG2 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Taurus_UMD|evm.model.AC_000167.1.611 Q5R8I2 RTRAF_PONAB 97.959 0.99187 1.0082 RTRAF - RNA transcription, translation and transport factor protein - Pongo abelii (Sumatran orangutan) - RTRAF gene RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex and is required for tRNA ligation. May be required for RNA transport. Taurus_UMD|evm.model.AC_000167.1.612 Q14112 NID2_HUMAN 67.315 0.981595 0.948364 NID2 - Nidogen-2 precursor - Homo sapiens (Human) - NID2 gene Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions. Taurus_UMD|evm.model.AC_000167.1.615 A5D7K8 PD2R_BOVIN 100.000 0.994475 1.00277 PTGDR - Prostaglandin D2 receptor - Bos taurus (Bovine) - PTGDR gene Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). Taurus_UMD|evm.model.AC_000167.1.617 Q32LQ1 PKHO2_BOVIN 99.198 0.996 1.002 PLEKHO2 - Pleckstrin homology domain-containing family O member 2 - Bos taurus (Bovine) - PLEKHO2 gene Taurus_UMD|evm.model.AC_000167.1.618 Q9H611 PIF1_HUMAN 90.172 0.803011 1.24337 PIF1 - ATP-dependent DNA helicase PIF1 - Homo sapiens (Human) - PIF1 gene DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. Taurus_UMD|evm.model.AC_000167.1.619 Q6ZRY4 RBPS2_HUMAN 95.556 0.913265 0.937799 RBPMS2 - RNA-binding protein with multiple splicing 2 - Homo sapiens (Human) - RBPMS2 gene RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (PubMed:25064856). Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity). Taurus_UMD|evm.model.AC_000167.1.620 O08608 OAZ2_MOUSE 100.000 0.801242 0.851852 Oaz2 - Ornithine decarboxylase antizyme 2 - Mus musculus (Mouse) - Oaz2 gene Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:16916800, PubMed:18508777, PubMed:24967154). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338). Taurus_UMD|evm.model.AC_000167.1.621 O15014 ZN609_HUMAN 97.177 0.862179 1.1056 ZNF609 - Zinc finger protein 609 - Homo sapiens (Human) - ZNF609 gene Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. Taurus_UMD|evm.model.AC_000167.1.622 Q15650 TRIP4_HUMAN 87.952 0.994828 0.998279 TRIP4 - Activating signal cointegrator 1 - Homo sapiens (Human) - TRIP4 gene Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity). Taurus_UMD|evm.model.AC_000167.1.623 Q5E9B2 PAF15_BOVIN 100.000 0.982143 1.00901 PCLAF - PCNA-associated factor - Bos taurus (Bovine) - PCLAF gene PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity). Taurus_UMD|evm.model.AC_000167.1.624 A7E3X2 KC1G1_BOVIN 100.000 0.995633 1.00219 CSNK1G1 - Casein kinase I isoform gamma-1 - Bos taurus (Bovine) - CSNK1G1 gene Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate. Phosphorylates CLSPN (By similarity). Taurus_UMD|evm.model.AC_000167.1.625 P80311 PPIB_BOVIN 100.000 0.990783 1.00463 PPIB - Peptidyl-prolyl cis-trans isomerase B precursor - Bos taurus (Bovine) - PPIB gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Taurus_UMD|evm.model.AC_000167.1.626 Q96L94 SNX22_HUMAN 73.575 0.988506 0.901554 SNX22 - Sorting nexin-22 - Homo sapiens (Human) - SNX22 gene May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). Taurus_UMD|evm.model.AC_000167.1.628 Q05B62 SNX1_BOVIN 99.808 0.996176 1.00192 SNX1 - Sorting nexin-1 - Bos taurus (Bovine) - SNX1 gene Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1). Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (By similarity). Taurus_UMD|evm.model.AC_000167.1.629 Q3T0U7 CIA2A_BOVIN 99.375 0.987578 1.00625 CIAO2A - Cytosolic iron-sulfur assembly component 2A - Bos taurus (Bovine) - CIAO2A gene Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation. May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1. Taurus_UMD|evm.model.AC_000167.1.630 Q8VDF3 DAPK2_MOUSE 95.393 0.70229 1.41622 Dapk2 - Death-associated protein kinase 2 - Mus musculus (Mouse) - Dapk2 gene Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity). Regulates granulocytes motility by controlling cell spreading and polarization (PubMed:24163421). Taurus_UMD|evm.model.AC_000167.1.631 Q15751 HERC1_HUMAN 98.005 0.999588 0.997737 HERC1 - Probable E3 ubiquitin-protein ligase HERC1 - Homo sapiens (Human) - HERC1 gene Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Taurus_UMD|evm.model.AC_000167.1.632 Q2HJF2 FXL22_BOVIN 100.000 0.789474 1.26106 FBXL22 - F-box and leucine-rich protein 22 - Bos taurus (Bovine) - FBXL22 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC) (By similarity). Taurus_UMD|evm.model.AC_000167.1.633 Q9Y6I4 UBP3_HUMAN 97.308 0.996161 1.00192 USP3 - Ubiquitin carboxyl-terminal hydrolase 3 - Homo sapiens (Human) - USP3 gene Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin. Taurus_UMD|evm.model.AC_000167.1.634 O43570 CAH12_HUMAN 77.465 0.994203 0.974576 CA12 - Carbonic anhydrase 12 precursor - Homo sapiens (Human) - CA12 gene Reversible hydration of carbon dioxide. Taurus_UMD|evm.model.AC_000167.1.635 Q5RDM3 APH1B_PONAB 67.704 0.990783 0.844358 APH1B - Gamma-secretase subunit APH-1B - Pongo abelii (Sumatran orangutan) - APH1B gene Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A (By similarity). Taurus_UMD|evm.model.AC_000167.1.636 Q2HJI8 RAB8B_BOVIN 99.517 0.990385 1.00483 RAB8B - Ras-related protein Rab-8B precursor - Bos taurus (Bovine) - RAB8B gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity). Taurus_UMD|evm.model.AC_000167.1.637 Q3T0B7 RS27L_BOVIN 100.000 0.642857 1.5 RPS27L - 40S ribosomal protein S27-like - Bos taurus (Bovine) - RPS27L gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, ribosomal small subunit assembly Taurus_UMD|evm.model.AC_000167.1.638 P83095 LACTB_BOVIN 100.000 0.996409 1.0018 LACTB - Serine beta-lactamase-like protein LACTB, mitochondrial precursor - Bos taurus (Bovine) - LACTB gene Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. Taurus_UMD|evm.model.AC_000167.1.639 P67937 TPM4_PIG 82.258 0.991968 1.00403 TPM4 - Tropomyosin alpha-4 chain - Sus scrofa (Pig) - TPM4 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. Taurus_UMD|evm.model.AC_000167.1.640 P58773 TPM1_COTJA 58.730 0.796178 0.552817 TPM1 - Tropomyosin alpha-1 chain - Coturnix japonica (Japanese quail) - TPM1 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Taurus_UMD|evm.model.AC_000167.1.641 Q9Y4G6 TLN2_HUMAN 97.246 0.999203 0.987411 TLN2 - Talin-2 - Homo sapiens (Human) - TLN2 gene As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). Taurus_UMD|evm.model.AC_000167.1.643 Q2KJ18 C2C4A_BOVIN 100.000 0.994521 1.00275 C2CD4A - C2 calcium-dependent domain-containing protein 4A - Bos taurus (Bovine) - C2CD4A gene May be involved in inflammatory process. May regulate cell architecture and adhesion (By similarity). Taurus_UMD|evm.model.AC_000167.1.644 Q2KJ18 C2C4A_BOVIN 74.695 0.809896 1.05495 C2CD4A - C2 calcium-dependent domain-containing protein 4A - Bos taurus (Bovine) - C2CD4A gene May be involved in inflammatory process. May regulate cell architecture and adhesion (By similarity). Taurus_UMD|evm.model.AC_000167.1.645 Q709C8 VP13C_HUMAN 86.022 0.999461 0.988809 VPS13C - Vacuolar protein sorting-associated protein 13C - Homo sapiens (Human) - VPS13C gene Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization. Taurus_UMD|evm.model.AC_000167.1.648 P35398 RORA_HUMAN 99.782 0.974414 0.89675 RORA - Nuclear receptor ROR-alpha - Homo sapiens (Human) - RORA gene Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development (PubMed:29656859). Regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, ARNTL/BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC1 and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling. Taurus_UMD|evm.model.AC_000167.1.650 Q0VCQ7 ICE2_BOVIN 99.898 0.997963 1.00102 ICE2 - Little elongation complex subunit 2 - Bos taurus (Bovine) - ICE2 gene Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Taurus_UMD|evm.model.AC_000167.1.651 A2SW69 ANXA2_SHEEP 100.000 0.994118 1.00295 ANXA2 - Annexin A2 - Ovis aries (Sheep) - ANXA2 gene Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Taurus_UMD|evm.model.AC_000167.1.652 Q99853 FOXB1_HUMAN 99.692 0.993865 1.00308 FOXB1 - Forkhead box protein B1 - Homo sapiens (Human) - FOXB1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, anatomical structure morphogenesis, axon target recognition, cell differentiation, cell migration in diencephalon Taurus_UMD|evm.model.AC_000167.1.655 Q12982 BNIP2_HUMAN 94.785 0.740319 1.39809 BNIP2 - BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 - Homo sapiens (Human) - BNIP2 gene Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins. Taurus_UMD|evm.model.AC_000167.1.656 P52657 T2AG_HUMAN 100.000 0.981818 1.00917 GTF2A2 - Transcription initiation factor IIA subunit 2 - Homo sapiens (Human) - GTF2A2 gene TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. Taurus_UMD|evm.model.AC_000167.1.657 Q7YQE1 GCNT3_BOVIN 100.000 0.995465 1.00227 GCNT3 - Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 - Bos taurus (Bovine) - GCNT3 gene Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. Taurus_UMD|evm.model.AC_000167.1.658 Q3UXZ6 FA81A_MOUSE 94.521 0.98645 1.01374 Fam81a - Protein FAM81A - Mus musculus (Mouse) - Fam81a gene Taurus_UMD|evm.model.AC_000167.1.659 Q12965 MYO1E_HUMAN 95.126 0.998197 1.0009 MYO1E - Unconventional myosin-Ie - Homo sapiens (Human) - MYO1E gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. Taurus_UMD|evm.model.AC_000167.1.660 O77689 CCNB2_BOVIN 99.497 0.994987 1.00251 CCNB2 - G2/mitotic-specific cyclin-B2 - Bos taurus (Bovine) - CCNB2 gene Essential for the control of the cell cycle at the G2/M (mitosis) transition. Taurus_UMD|evm.model.AC_000167.1.661 Q6ZNA4 RN111_HUMAN 95.779 0.99799 1.00101 RNF111 - E3 ubiquitin-protein ligase Arkadia - Homo sapiens (Human) - RNF111 gene E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695). Associates with UBE2D2 as an E2 enzyme (PubMed:22411132). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493). Mediates ubiquitination and degradation of sumoylated PML (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity). Taurus_UMD|evm.model.AC_000167.1.662 Q8CH25 SLTM_MOUSE 90.773 0.481366 0.936954 Sltm - SAFB-like transcription modulator - Mus musculus (Mouse) - Sltm gene When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. Taurus_UMD|evm.model.AC_000167.1.663 Q2KI23 MINY2_BOVIN 97.302 0.996774 0.984127 MINDY2 - Ubiquitin carboxyl-terminal hydrolase MINDY-2 - Bos taurus (Bovine) - MINDY2 gene Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. Can also bind to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33' and 'Lys-63'. May play a regulatory role at the level of protein turnover. Taurus_UMD|evm.model.AC_000167.1.664 Q10741 ADA10_BOVIN 100.000 0.99733 1.00134 ADAM10 - Disintegrin and metalloproteinase domain-containing protein 10 precursor - Bos taurus (Bovine) - ADAM10 gene Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:10097139). Contributes to the normal cleavage of the cellular prion protein (By similarity). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (By similarity). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (By similarity). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (By similarity). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (By similarity). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (By similarity). Taurus_UMD|evm.model.AC_000167.1.665 P27656 LIPC_MOUSE 72.368 0.484009 0.919608 Lipc - Hepatic triacylglycerol lipase precursor - Mus musculus (Mouse) - Lipc gene Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (By similarity). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (By similarity). Taurus_UMD|evm.model.AC_000167.1.666 P54105 ICLN_HUMAN 92.994 0.987342 0.666667 CLNS1A - Methylosome subunit pICln - Homo sapiens (Human) - CLNS1A gene Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:21081503, PubMed:18984161). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. Taurus_UMD|evm.model.AC_000167.1.667 O43315 AQP9_HUMAN 82.022 0.98155 0.918644 AQP9 - Aquaporin-9 - Homo sapiens (Human) - AQP9 gene Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small, non-charged solutes including carbamides, polyols, purines, and pyrimidines. Taurus_UMD|evm.model.AC_000167.1.669 O94788 AL1A2_HUMAN 87.838 0.995643 0.8861 ALDH1A2 - Retinal dehydrogenase 2 - Homo sapiens (Human) - ALDH1A2 gene Converts retinaldehyde to retinoic acid (PubMed:29240402). Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral (By similarity). Taurus_UMD|evm.model.AC_000167.1.670 Q17QE3 GRL1A_BOVIN 100.000 0.994609 1.0027 POLR2M - DNA-directed RNA polymerase II subunit GRINL1A - Bos taurus (Bovine) - POLR2M gene Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in Mediator complex-dependent regulation of transcription activation. Acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. Taurus_UMD|evm.model.AC_000167.1.671 P0CAP1 MYZAP_HUMAN 91.202 0.99569 0.995708 MYZAP - Myocardial zonula adherens protein precursor - Homo sapiens (Human) - MYZAP gene Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity). Taurus_UMD|evm.model.AC_000167.1.672 Q0VF96 CGNL1_HUMAN 86.186 0.998454 0.993856 CGNL1 - Cingulin-like protein 1 - Homo sapiens (Human) - CGNL1 gene May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. Taurus_UMD|evm.model.AC_000167.1.674 Q60420 HTF4_MESAU 96.322 0.76007 1.30664 TCF12 - Transcription factor 12 - Mesocricetus auratus (Golden hamster) - TCF12 gene Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Participates in the control of inducible RP4 gene expression in salivary cells (By similarity). Binds to the RIPE3 element of the insulin II promoter. Taurus_UMD|evm.model.AC_000167.1.675 Q99081 HTF4_HUMAN 99.074 0.816794 0.192082 TCF12 - Transcription factor 12 - Homo sapiens (Human) - TCF12 gene Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Taurus_UMD|evm.model.AC_000167.1.677 Q6N043 Z280D_HUMAN 88.442 0.992821 0.995914 ZNF280D - Zinc finger protein 280D - Homo sapiens (Human) - ZNF280D gene May function as a transcription factor. Taurus_UMD|evm.model.AC_000167.1.678 Q2KIQ2 MNS1_BOVIN 98.458 0.995595 0.917172 MNS1 - Meiosis-specific nuclear structural protein 1 - Bos taurus (Bovine) - MNS1 gene May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis (By similarity). Required for sperm flagella assembly (By similarity). May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules (By similarity). Taurus_UMD|evm.model.AC_000167.1.679 Q8N6V9 TEX9_HUMAN 84.143 0.994832 0.98977 TEX9 - Testis-expressed protein 9 - Homo sapiens (Human) - TEX9 gene Taurus_UMD|evm.model.AC_000167.1.680 Q2KHR2 RFX7_HUMAN 91.716 0.931154 1.05503 RFX7 - DNA-binding protein RFX7 - Homo sapiens (Human) - RFX7 gene chromatin, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000167.1.681 P46934 NEDD4_HUMAN 95.771 0.890244 0.683851 NEDD4 - E3 ubiquitin-protein ligase NEDD4 - Homo sapiens (Human) - NEDD4 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Taurus_UMD|evm.model.AC_000167.1.682 Q2VWP7 PRTG_HUMAN 87.182 0.927101 1.01391 PRTG - Protogenin precursor - Homo sapiens (Human) - PRTG gene May play a role in anteroposterior axis elongation. Taurus_UMD|evm.model.AC_000167.1.683 Q9Y3Y4 PYGO1_HUMAN 95.408 0.930952 1.00239 PYGO1 - Pygopus homolog 1 - Homo sapiens (Human) - PYGO1 gene Involved in signal transduction through the Wnt pathway. Taurus_UMD|evm.model.AC_000167.1.684 Q863A4 DAAF4_PONPY 88.571 0.992891 1.00476 DNAAF4 - Dynein axonemal assembly factor 4 - Pongo pygmaeus (Bornean orangutan) - DNAAF4 gene Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility (By similarity). Taurus_UMD|evm.model.AC_000167.1.685 H3BRN8 CO065_HUMAN 86.777 0.983471 1 C15orf65 - Uncharacterized protein C15orf65 - Homo sapiens (Human) - C15orf65 gene Taurus_UMD|evm.model.AC_000167.1.686 Q5R6R3 CCPG1_PONAB 83.355 0.962917 1.00372 CCPG1 - Cell cycle progression protein 1 - Pongo abelii (Sumatran orangutan) - CCPG1 gene Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42. May be involved in cell cycle regulation (By similarity). Taurus_UMD|evm.model.AC_000167.1.687 Q1LZA0 PIGB_BOVIN 86.322 0.995851 0.890943 PIGB - GPI mannosyltransferase 3 - Bos taurus (Bovine) - PIGB gene Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity). Taurus_UMD|evm.model.AC_000167.1.688 Q4LE85 RB27A_PIG 96.380 0.990991 1.00452 RAB27A - Ras-related protein Rab-27A - Sus scrofa (Pig) - RAB27A gene Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Taurus_UMD|evm.model.AC_000167.1.689 Q3SZ12 RLP24_BOVIN 100.000 0.81407 1.22086 RSL24D1 - Probable ribosome biogenesis protein RLP24 - Bos taurus (Bovine) - RSL24D1 gene Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity). Taurus_UMD|evm.model.AC_000167.1.692 Q5RFQ4 WDR72_PONAB 84.093 0.998986 0.897996 WDR72 - WD repeat-containing protein 72 - Pongo abelii (Sumatran orangutan) - WDR72 gene Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. Taurus_UMD|evm.model.AC_000167.1.693 P15927 RFA2_HUMAN 91.129 0.984 0.462963 RPA2 - Replication protein A 32 kDa subunit - Homo sapiens (Human) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Taurus_UMD|evm.model.AC_000167.1.694 Q8BHS3 RBM22_MOUSE 69.960 0.829545 0.628571 Rbm22 - Pre-mRNA-splicing factor RBM22 - Mus musculus (Mouse) - Rbm22 gene Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. Taurus_UMD|evm.model.AC_000167.1.696 Q9UBC0 HNF6_HUMAN 98.925 0.995708 1.00215 ONECUT1 - Hepatocyte nuclear factor 6 - Homo sapiens (Human) - ONECUT1 gene Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. Taurus_UMD|evm.model.AC_000167.1.698 Q32MH5 F214A_HUMAN 84.298 0.998163 1.01208 FAM214A - Protein FAM214A - Homo sapiens (Human) - FAM214A gene Taurus_UMD|evm.model.AC_000167.1.699 Q28055 ARP19_BOVIN 100.000 0.982301 1.00893 ARPP19 - cAMP-regulated phosphoprotein 19 - Bos taurus (Bovine) - ARPP19 gene Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression (By similarity). Taurus_UMD|evm.model.AC_000167.1.700 Q9Y4I1 MYO5A_HUMAN 97.251 0.998921 0.998922 MYO5A - Unconventional myosin-Va - Homo sapiens (Human) - MYO5A gene Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation. Taurus_UMD|evm.model.AC_000167.1.701 Q9NQX4 MYO5C_HUMAN 94.939 0.358396 0.916188 MYO5C - Unconventional myosin-Vc - Homo sapiens (Human) - MYO5C gene May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues. Taurus_UMD|evm.model.AC_000167.1.702 Q80ZD0 GNB5_TAMST 99.433 0.99435 1.00283 GNB5 - Guanine nucleotide-binding protein subunit beta-5 - Tamias striatus (Eastern chipmunk) - GNB5 gene Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). Taurus_UMD|evm.model.AC_000167.1.703 Q9HD36 B2L10_HUMAN 54.902 0.761905 0.926471 BCL2L10 - Bcl-2-like protein 10 - Homo sapiens (Human) - BCL2L10 gene Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (PubMed:11689480, PubMed:11278245). Increases binding of AHCYL1/IRBIT to ITPR1 (PubMed:27995898). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (PubMed:27995898). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). Taurus_UMD|evm.model.AC_000167.1.704 Q2T9N1 F1142_BOVIN 91.304 0.135802 0.324 FAM114A1 - Protein FAM114A2 - Bos taurus (Bovine) - FAM114A1 gene Taurus_UMD|evm.model.AC_000167.1.705 Q16659 MK06_HUMAN 97.645 0.997234 1.00277 MAPK6 - Mitogen-activated protein kinase 6 - Homo sapiens (Human) - MAPK6 gene Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). Taurus_UMD|evm.model.AC_000167.1.706 Q8WVC0 LEO1_HUMAN 97.156 0.99701 1.0045 LEO1 - RNA polymerase-associated protein LEO1 - Homo sapiens (Human) - LEO1 gene Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. Taurus_UMD|evm.model.AC_000167.1.707 Q5XJE5 LEO1_MOUSE 64.815 0.936364 0.494753 Leo1 - RNA polymerase-associated protein LEO1 - Mus musculus (Mouse) - Leo1 gene Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling (By similarity). Taurus_UMD|evm.model.AC_000167.1.708 Q9NYL9 TMOD3_HUMAN 94.393 0.954955 0.315341 TMOD3 - Tropomodulin-3 - Homo sapiens (Human) - TMOD3 gene Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). Taurus_UMD|evm.model.AC_000167.1.709 Q9NYL9 TMOD3_HUMAN 96.842 0.696296 0.383523 TMOD3 - Tropomodulin-3 - Homo sapiens (Human) - TMOD3 gene Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). Taurus_UMD|evm.model.AC_000167.1.710 Q9NZR1 TMOD2_HUMAN 97.151 0.855746 1.16524 TMOD2 - Tropomodulin-2 - Homo sapiens (Human) - TMOD2 gene Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). Taurus_UMD|evm.model.AC_000167.1.711 Q1JQA8 LYSM2_BOVIN 100.000 0.990741 1.00465 LYSMD2 - LysM and putative peptidoglycan-binding domain-containing protein 2 - Bos taurus (Bovine) - LYSMD2 gene Taurus_UMD|evm.model.AC_000167.1.712 A6QLI2 SCG3_BOVIN 100.000 0.995763 1.00212 SCG3 - Secretogranin-3 precursor - Bos taurus (Bovine) - SCG3 gene Member of the granin protein family that regulates the biogenesis of secretory granules (By similarity). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (By similarity). Taurus_UMD|evm.model.AC_000167.1.714 Q8TDJ6 DMXL2_HUMAN 97.521 0.0401741 0.98386 DMXL2 - DmX-like protein 2 - Homo sapiens (Human) - DMXL2 gene May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). Taurus_UMD|evm.model.AC_000167.1.715 Q6ZMI3 GLDN_HUMAN 85.921 0.996283 0.976407 GLDN - Gliomedin precursor - Homo sapiens (Human) - GLDN gene Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. Taurus_UMD|evm.model.AC_000167.1.716 P46194 CP19A_BOVIN 99.795 0.99591 0.972167 CYP19A1 - Aromatase - Bos taurus (Bovine) - CYP19A1 gene A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Taurus_UMD|evm.model.AC_000167.1.717 P79304 CP193_PIG 91.525 0.495726 0.233533 CYP19A3 - Aromatase 3 - Sus scrofa (Pig) - CYP19A3 gene Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Taurus_UMD|evm.model.AC_000167.1.718 P46194 CP19A_BOVIN 95.522 0.985185 0.26839 CYP19A1 - Aromatase - Bos taurus (Bovine) - CYP19A1 gene A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Taurus_UMD|evm.model.AC_000167.1.720 Q5GJ75 TP8L3_HUMAN 96.078 0.990244 0.702055 TNFAIP8L3 - Tumor necrosis factor alpha-induced protein 8-like protein 3 - Homo sapiens (Human) - TNFAIP8L3 gene Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling. Taurus_UMD|evm.model.AC_000167.1.721 Q9UPM8 AP4E1_HUMAN 89.506 0.998267 1.01495 AP4E1 - AP-4 complex subunit epsilon-1 - Homo sapiens (Human) - AP4E1 gene Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). Taurus_UMD|evm.model.AC_000167.1.722 Q8TCT8 SPP2A_HUMAN 88.740 0.996183 1.00769 SPPL2A - Signal peptide peptidase-like 2A precursor - Homo sapiens (Human) - SPPL2A gene Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). Taurus_UMD|evm.model.AC_000167.1.723 Q96QT4 TRPM7_HUMAN 96.141 0.998929 1.00107 TRPM7 - Transient receptor potential cation channel subfamily M member 7 - Homo sapiens (Human) - TRPM7 gene Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). Taurus_UMD|evm.model.AC_000167.1.724 Q4R6D3 UBP50_MACFA 81.452 0.972752 0.983914 USP50 - Putative ubiquitin carboxyl-terminal hydrolase 50 - Macaca fascicularis (Crab-eating macaque) - USP50 gene May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Taurus_UMD|evm.model.AC_000167.1.725 P40818 UBP8_HUMAN 88.014 0.998158 0.971377 USP8 - Ubiquitin carboxyl-terminal hydrolase 8 - Homo sapiens (Human) - USP8 gene Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). Taurus_UMD|evm.model.AC_000167.1.727 Q06547 GABP1_HUMAN 100.000 0.987805 0.622785 GABPB1 - GA-binding protein subunit beta-1 - Homo sapiens (Human) - GABPB1 gene Transcription factor capable of interacting with purine rich repeats (GA repeats) (PubMed:8441384, PubMed:10675337, PubMed:8816484). Acts as a a master regulator of nuclear-encoded mitochondrial genes (By similarity). Taurus_UMD|evm.model.AC_000167.1.728 Q5EA83 DCHS_BOVIN 100.000 0.996965 1.00152 HDC - Histidine decarboxylase - Bos taurus (Bovine) - HDC gene Catalyzes the biosynthesis of histamine from histidine. Taurus_UMD|evm.model.AC_000167.1.729 Q06547 GABP1_HUMAN 99.338 0.857143 0.443038 GABPB1 - GA-binding protein subunit beta-1 - Homo sapiens (Human) - GABPB1 gene Transcription factor capable of interacting with purine rich repeats (GA repeats) (PubMed:8441384, PubMed:10675337, PubMed:8816484). Acts as a a master regulator of nuclear-encoded mitochondrial genes (By similarity). Taurus_UMD|evm.model.AC_000167.1.730 A0A075B6T8 TVA91_HUMAN 74.419 0.752212 1.00893 TRAV9-1 - T cell receptor alpha variable 9-1 precursor - Homo sapiens (Human) - TRAV9-1 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.731 A0A0B4J235 TVAM2_HUMAN 61.165 0.682759 1.28319 TRAV13-2 - T cell receptor alpha variable 13-2 precursor - Homo sapiens (Human) - TRAV13-2 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000167.1.732 O14975 S27A2_HUMAN 85.161 0.996779 1.00161 SLC27A2 - Very long-chain acyl-CoA synthetase - Homo sapiens (Human) - SLC27A2 gene Acyl CoA synthetase that activates long-chain and very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (PubMed:10198260, PubMed:10749848, PubMed:11980911). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PubMed:10198260). Does not activate C24 bile acids, cholate and chenodeoxycholate (PubMed:11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). Exhibits long-chain fatty acids (LCFA) transport activity and plays an important role in hepatic fatty acid uptake (PubMed:20530735). Taurus_UMD|evm.model.AC_000167.1.733 Q8TF62 AT8B4_HUMAN 93.078 0.732548 0.925336 ATP8B4 - Probable phospholipid-transporting ATPase IM - Homo sapiens (Human) - ATP8B4 gene Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Taurus_UMD|evm.model.AC_000167.1.734 Q8N5C7 DTWD1_HUMAN 87.500 0.993377 0.993421 DTWD1 - tRNA-uridine aminocarboxypropyltransferase 1 - Homo sapiens (Human) - DTWD1 gene Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)). Taurus_UMD|evm.model.AC_000167.1.735 Q96M60 F227B_HUMAN 68.258 0.988827 0.704724 FAM227B - Protein FAM227B - Homo sapiens (Human) - FAM227B gene Taurus_UMD|evm.model.AC_000167.1.736 Q5D0X0 FGF7_CEREL 100.000 0.989744 1.00515 FGF7 - Fibroblast growth factor 7 precursor - Cervus elaphus (Red deer) - FGF7 gene Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000167.1.737 Q56JZ1 RL13_BOVIN 100.000 0.897059 0.322275 RPL13 - 60S ribosomal protein L13 - Bos taurus (Bovine) - RPL13 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the LSU, it is probably required for its formation and the maturation of rRNAs. Plays a role in bone development. Taurus_UMD|evm.model.AC_000167.1.738 Q01415 GALK2_HUMAN 93.668 0.995643 1.00218 GALK2 - N-acetylgalactosamine kinase - Homo sapiens (Human) - GALK2 gene Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates. Taurus_UMD|evm.model.AC_000167.1.739 P61203 CSN2_RAT 100.000 0.995495 1.00226 Cops2 - COP9 signalosome complex subunit 2 - Rattus norvegicus (Rat) - Cops2 gene Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. Taurus_UMD|evm.model.AC_000167.1.740 Q93073 SBP2L_HUMAN 97.093 0.327586 0.474114 SECISBP2L - Selenocysteine insertion sequence-binding protein 2-like - Homo sapiens (Human) - SECISBP2L gene Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro. Taurus_UMD|evm.model.AC_000167.1.741 Q93073 SBP2L_HUMAN 89.401 0.972973 0.201635 SECISBP2L - Selenocysteine insertion sequence-binding protein 2-like - Homo sapiens (Human) - SECISBP2L gene Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro. Taurus_UMD|evm.model.AC_000167.1.742 Q6S5L8 SHC4_HUMAN 86.825 0.996737 0.973016 SHC4 - SHC-transforming protein 4 - Homo sapiens (Human) - SHC4 gene Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. Taurus_UMD|evm.model.AC_000167.1.743 O94986 CE152_HUMAN 74.107 0.998878 1.04211 CEP152 - Centrosomal protein of 152 kDa - Homo sapiens (Human) - CEP152 gene Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). Taurus_UMD|evm.model.AC_000167.1.744 P98133 FBN1_BOVIN 100.000 0.971893 1.02856 FBN1 - Fibrillin-1 precursor - Bos taurus (Bovine) - FBN1 gene Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function. Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1. Binds heparin and this interaction plays an important role in the assembly of microfibrils. Taurus_UMD|evm.model.AC_000167.1.745 P70583 DUT_RAT 75.510 0.803419 1.14146 Dut - Deoxyuridine 5'-triphosphate nucleotidohydrolase - Rattus norvegicus (Rat) - Dut gene This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor. Taurus_UMD|evm.model.AC_000167.1.746 P55015 S12A1_RABIT 92.403 0.998233 1.03003 SLC12A1 - Solute carrier family 12 member 1 - Oryctolagus cuniculus (Rabbit) - SLC12A1 gene Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. Taurus_UMD|evm.model.AC_000167.1.747 Q9P2K5 MYEF2_HUMAN 95.833 0.996672 1.00167 MYEF2 - Myelin expression factor 2 - Homo sapiens (Human) - MYEF2 gene Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity). Taurus_UMD|evm.model.AC_000167.1.748 Q71RS6 NCKX5_HUMAN 90.600 0.994024 1.004 SLC24A5 - Sodium/potassium/calcium exchanger 5 precursor - Homo sapiens (Human) - SLC24A5 gene Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Taurus_UMD|evm.model.AC_000167.1.749 Q8NFY4 SEM6D_HUMAN 97.204 0.998138 1.00093 SEMA6D - Semaphorin-6D precursor - Homo sapiens (Human) - SEMA6D gene Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Taurus_UMD|evm.model.AC_000167.1.752 P02281 H2B11_XENLA 45.946 0.496552 1.15079 Histone H2B 1.1 - Xenopus laevis (African clawed frog) Taurus_UMD|evm.model.AC_000167.1.753 E2RK33 GATC_CANLF 60.000 0.982759 0.374194 GATC - Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial precursor - Canis lupus familiaris (Dog) - GATC gene Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Taurus_UMD|evm.model.AC_000167.1.754 Q9Y6N5 SQOR_HUMAN 91.556 0.995565 1.00222 SQOR - Sulfide:quinone oxidoreductase, mitochondrial precursor - Homo sapiens (Human) - SQOR gene Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro) (PubMed:22852582). It is believed the in vivo electron acceptor is glutathione (PubMed:25225291,PubMed:29715001). Taurus_UMD|evm.model.AC_000167.1.755 Q08DU8 BL1S6_BOVIN 100.000 0.988439 1.00581 BLOC1S6 - Biogenesis of lysosome-related organelles complex 1 subunit 6 - Bos taurus (Bovine) - BLOC1S6 gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process (By similarity). Taurus_UMD|evm.model.AC_000167.1.756 O14863 ZNT4_HUMAN 94.393 0.993023 1.00233 SLC30A4 - Zinc transporter 4 - Homo sapiens (Human) - SLC30A4 gene Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment. Taurus_UMD|evm.model.AC_000167.1.757 Q9C002 NMES1_HUMAN 83.099 0.636364 1.3253 NMES1 - Normal mucosa of esophagus-specific gene 1 protein - Homo sapiens (Human) - NMES1 gene mitochondrial respiratory chain complex IV, nucleus Taurus_UMD|evm.model.AC_000167.1.758 A7YSY2 SPA5L_BOVIN 100.000 0.997396 1.0013 SPATA5L1 - Spermatogenesis-associated protein 5-like protein 1 - Bos taurus (Bovine) - SPATA5L1 gene cytoplasm, spindle, ATPase activity Taurus_UMD|evm.model.AC_000167.1.759 Q2HJ74 GATM_BOVIN 100.000 0.995283 1.00236 GATM - Glycine amidinotransferase, mitochondrial precursor - Bos taurus (Bovine) - GATM gene Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity). Taurus_UMD|evm.model.AC_000167.1.760 O43868 S28A2_HUMAN 85.714 0.995455 1.00304 SLC28A2 - Sodium/nucleoside cotransporter 2 - Homo sapiens (Human) - SLC28A2 gene Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues. Taurus_UMD|evm.model.AC_000167.1.761 Q7M4L6 SHF_HUMAN 83.590 0.890736 0.995272 SHF - SH2 domain-containing adapter protein F - Homo sapiens (Human) - SHF gene Adapter protein which may play a role in the regulation of apoptosis in response to PDGF. Taurus_UMD|evm.model.AC_000167.1.762 Q8HZK3 DUOX1_PIG 93.818 0.998713 1.00064 DUOX1 - Dual oxidase 1 precursor - Sus scrofa (Pig) - DUOX1 gene Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. Taurus_UMD|evm.model.AC_000167.1.763 Q1HG43 DOXA1_HUMAN 84.840 0.994083 0.985423 DUOXA1 - Dual oxidase maturation factor 1 - Homo sapiens (Human) - DUOXA1 gene May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1. Taurus_UMD|evm.model.AC_000167.1.764 Q1HG44 DOXA2_HUMAN 79.128 0.993769 1.00313 DUOXA2 - Dual oxidase maturation factor 2 - Homo sapiens (Human) - DUOXA2 gene Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis. Taurus_UMD|evm.model.AC_000167.1.765 Q8HZK2 DUOX2_PIG 89.709 0.998706 1.00065 DUOX2 - Dual oxidase 2 precursor - Sus scrofa (Pig) - DUOX2 gene Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. Taurus_UMD|evm.model.AC_000167.1.766 Q58D31 DHSO_BOVIN 100.000 0.994398 1.00281 SORD - Sorbitol dehydrogenase - Bos taurus (Bovine) - SORD gene Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with xylitol, D-sorbitol (D-glucitol) and L-iditol as substrates, leading to the C2-oxidized products D-xylulose, D-fructose and L-sorbose, respectively (PubMed:9143345). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). Cannot use NADP(+) as the electron acceptor. Has no activity on ethanol, methanol, glycerol, galactitol and fructose 6-phosphate (PubMed:9143345). Taurus_UMD|evm.model.AC_000167.1.767 Q8N5G0 SIM20_HUMAN 97.143 0.225166 2.25373 SMIM20 - Small integral membrane protein 20 - Homo sapiens (Human) - SMIM20 gene Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (PubMed:26321642). Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C (PubMed:26321642). Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover (PubMed:26321642). Taurus_UMD|evm.model.AC_000167.1.768 P10515 ODP2_HUMAN 65.482 0.947644 0.295209 DLAT - Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor - Homo sapiens (Human) - DLAT gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Taurus_UMD|evm.model.AC_000167.1.769 Q9ULW0 TPX2_HUMAN 62.048 0.683761 0.313253 TPX2 - Targeting protein for Xklp2 - Homo sapiens (Human) - TPX2 gene Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940). Taurus_UMD|evm.model.AC_000167.1.770 Q5RCP8 H2B2E_PONAB 91.270 0.984127 1 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000167.1.771 Q96AC1 FERM2_HUMAN 98.263 0.99711 1.01765 FERMT2 - Fermitin family homolog 2 - Homo sapiens (Human) - FERMT2 gene Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. Taurus_UMD|evm.model.AC_000167.1.772 O46606 DDHD1_BOVIN 99.886 0.997717 1.00114 DDHD1 - Phospholipase DDHD1 - Bos taurus (Bovine) - DDHD1 gene Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid (PubMed:9488669). Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). Taurus_UMD|evm.model.AC_000167.1.773 Q10126 YSM6_CAEEL 25.735 0.84375 1.03226 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000167.1.774 Q2KJH1 BMP4_BOVIN 100.000 0.625767 1.59413 BMP4 - Bone morphogenetic protein 4 precursor - Bos taurus (Bovine) - BMP4 gene Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (By similarity). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (By similarity). Taurus_UMD|evm.model.AC_000167.1.775 Q9MYN5 CDKN3_PIG 96.226 0.99061 1.00472 CDKN3 - Cyclin-dependent kinase inhibitor 3 - Sus scrofa (Pig) - CDKN3 gene May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000167.1.776 O35372 CNIH1_MOUSE 100.000 0.986207 1.00694 Cnih1 - Protein cornichon homolog 1 - Mus musculus (Mouse) - Cnih1 gene Involved in the selective transport and maturation of TGF-alpha family proteins. Taurus_UMD|evm.model.AC_000167.1.778 Q5R6P6 GMFB_PONAB 87.117 0.987805 1.15493 GMFB - Glia maturation factor beta - Pongo abelii (Sumatran orangutan) - GMFB gene This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. Taurus_UMD|evm.model.AC_000167.1.779 Q99675 CGRF1_HUMAN 96.000 0.971631 0.849398 CGRRF1 - Cell growth regulator with RING finger domain protein 1 - Homo sapiens (Human) - CGRRF1 gene Able to inhibit growth in several cell lines. Taurus_UMD|evm.model.AC_000167.1.780 Q9UPU9 SMAG1_HUMAN 97.479 0.96875 1.02507 SAMD4A - Protein Smaug homolog 1 - Homo sapiens (Human) - SAMD4A gene Acts as a translational repressor of SRE-containing messengers. Taurus_UMD|evm.model.AC_000167.1.781 P45478 PPT1_BOVIN 62.238 0.955224 0.437908 PPT1 - Palmitoyl-protein thioesterase 1 precursor - Bos taurus (Bovine) - PPT1 gene Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. Taurus_UMD|evm.model.AC_000167.1.782 Q5E984 TCTP_BOVIN 100.000 0.98 0.581395 TPT1 - Translationally-controlled tumor protein - Bos taurus (Bovine) - TPT1 gene Involved in calcium binding and microtubule stabilization. Taurus_UMD|evm.model.AC_000167.1.783 P30793 GCH1_HUMAN 91.200 0.992 1 GCH1 - GTP cyclohydrolase 1 - Homo sapiens (Human) - GCH1 gene Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. Taurus_UMD|evm.model.AC_000167.1.784 O75717 WDHD1_HUMAN 88.771 0.998227 0.999114 WDHD1 - WD repeat and HMG-box DNA-binding protein 1 - Homo sapiens (Human) - WDHD1 gene Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Taurus_UMD|evm.model.AC_000167.1.785 Q0VC91 SOCS4_BOVIN 100.000 0.995465 1.00227 SOCS4 - Suppressor of cytokine signaling 4 - Bos taurus (Bovine) - SOCS4 gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity). Taurus_UMD|evm.model.AC_000167.1.786 Q5E9L3 MISSL_BOVIN 100.000 0.559719 1.77917 MAPK1IP1L - MAPK-interacting and spindle-stabilizing protein-like - Bos taurus (Bovine) - MAPK1IP1L gene Taurus_UMD|evm.model.AC_000167.1.788 P17931 LEG3_HUMAN 87.407 0.77907 0.688 LGALS3 - Galectin-3 - Homo sapiens (Human) - LGALS3 gene Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. Taurus_UMD|evm.model.AC_000167.1.789 Q15398 DLGP5_HUMAN 77.160 0.987013 1.00118 DLGAP5 - Disks large-associated protein 5 - Homo sapiens (Human) - DLGAP5 gene Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. Taurus_UMD|evm.model.AC_000167.1.790 Q9NWN3 FBX34_HUMAN 84.712 0.928292 1.07876 FBXO34 - F-box only protein 34 - Homo sapiens (Human) - FBXO34 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000167.1.791 Q6ZNE5 BAKOR_HUMAN 95.732 0.960861 1.03862 ATG14 - Beclin 1-associated autophagy-related key regulator - Homo sapiens (Human) - ATG14 gene Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity). Taurus_UMD|evm.model.AC_000167.1.792 Q92117 TBP_PROFL 88.265 0.515873 1.26 TBP - TATA-box-binding protein - Protobothrops flavoviridis (Habu) - TBP gene General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Taurus_UMD|evm.model.AC_000167.1.794 Q86UP2 KTN1_HUMAN 92.704 0.998527 1.00074 KTN1 - Kinectin - Homo sapiens (Human) - KTN1 gene Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. Taurus_UMD|evm.model.AC_000167.1.795 Q9HAT8 PELI2_HUMAN 98.810 0.995249 1.00238 PELI2 - E3 ubiquitin-protein ligase pellino homolog 2 - Homo sapiens (Human) - PELI2 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Taurus_UMD|evm.model.AC_000167.1.796 Q9NX78 TM260_HUMAN 83.191 0.982709 0.981612 TMEM260 - Transmembrane protein 260 - Homo sapiens (Human) - TMEM260 gene Taurus_UMD|evm.model.AC_000167.1.797 P32243 OTX2_HUMAN 98.962 0.993103 1.00346 OTX2 - Homeobox protein OTX2 - Homo sapiens (Human) - OTX2 gene Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'. Taurus_UMD|evm.model.AC_000167.1.798 P68370 TBA1A_RAT 74.318 0.963145 0.902439 Tuba1a - Tubulin alpha-1A chain - Rattus norvegicus (Rat) - Tuba1a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Taurus_UMD|evm.model.AC_000167.1.799 O00471 EXOC5_HUMAN 91.757 0.997245 1.02542 EXOC5 - Exocyst complex component 5 - Homo sapiens (Human) - EXOC5 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Taurus_UMD|evm.model.AC_000167.1.800 Q5E9X5 AP5M1_BOVIN 100.000 0.995927 1.00204 AP5M1 - AP-5 complex subunit mu-1 - Bos taurus (Bovine) - AP5M1 gene As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. Taurus_UMD|evm.model.AC_000167.1.801 Q147X3 NAA30_HUMAN 92.011 0.994444 0.994475 NAA30 - N-alpha-acetyltransferase 30 - Homo sapiens (Human) - NAA30 gene Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate. Taurus_UMD|evm.model.AC_000167.1.802 Q9NVL8 CC198_HUMAN 67.626 0.753799 1.11149 CCDC198 - Uncharacterized protein CCDC198 - Homo sapiens (Human) - CCDC198 gene Taurus_UMD|evm.model.AC_000167.1.803 A4IF30 S35F4_HUMAN 96.444 0.995565 0.865643 SLC35F4 - Solute carrier family 35 member F4 - Homo sapiens (Human) - SLC35F4 gene Putative solute transporter. Taurus_UMD|evm.model.AC_000167.1.804 Q2TA21 ARMD4_BOVIN 99.868 0.997372 1.00132 ARMH4 - Armadillo-like helical domain-containing protein 4 precursor - Bos taurus (Bovine) - ARMH4 gene Taurus_UMD|evm.model.AC_000167.1.805 Q3ZBD2 ARP10_BOVIN 97.531 0.933025 1.03837 ACTR10 - Actin-related protein 10 - Bos taurus (Bovine) - ACTR10 gene dynactin complex, microtubule-based movement, retrograde axonal transport of mitochondrion Taurus_UMD|evm.model.AC_000167.1.806 Q58DU5 PSA3_BOVIN 100.000 0.992188 1.00392 PSMA3 - Proteasome subunit alpha type-3 - Bos taurus (Bovine) - PSMA3 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. Taurus_UMD|evm.model.AC_000167.1.807 P29374 ARI4A_HUMAN 93.265 0.998415 1.00398 ARID4A - AT-rich interactive domain-containing protein 4A - Homo sapiens (Human) - ARID4A gene DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). Taurus_UMD|evm.model.AC_000167.1.808 Q9BVV6 TALD3_HUMAN 79.121 0.977128 1.02674 KIAA0586 - Protein TALPID3 - Homo sapiens (Human) - KIAA0586 gene Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). Taurus_UMD|evm.model.AC_000167.1.809 Q96B18 DACT3_HUMAN 90.000 0.0360248 1.27981 DACT3 - Dapper homolog 3 - Homo sapiens (Human) - DACT3 gene May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Taurus_UMD|evm.model.AC_000167.1.810 Q96T55 KCNKG_HUMAN 38.288 0.827715 0.864078 KCNK16 - Potassium channel subfamily K member 16 - Homo sapiens (Human) - KCNK16 gene Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Taurus_UMD|evm.model.AC_000167.1.811 Q9Y4D1 DAAM1_HUMAN 97.681 0.998129 0.991651 DAAM1 - Disheveled-associated activator of morphogenesis 1 - Homo sapiens (Human) - DAAM1 gene Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). Taurus_UMD|evm.model.AC_000167.1.812 Q8IZ08 GP135_HUMAN 84.200 0.991968 1.0081 GPR135 - G-protein coupled receptor 135 - Homo sapiens (Human) - GPR135 gene Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). Taurus_UMD|evm.model.AC_000167.1.813 Q3SX04 T3HPD_BOVIN 100.000 0.994366 1.00282 L3HYPDH - Trans-L-3-hydroxyproline dehydratase - Bos taurus (Bovine) - L3HYPDH gene Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Taurus_UMD|evm.model.AC_000167.1.814 Q9P055 JKAMP_HUMAN 98.071 0.99359 1.00322 JKAMP - JNK1/MAPK8-associated membrane protein - Homo sapiens (Human) - JKAMP gene May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity). Taurus_UMD|evm.model.AC_000167.1.815 Q2T9Z6 CC175_BOVIN 100.000 0.917738 1.07459 CCDC175 - Coiled-coil domain-containing protein 175 - Bos taurus (Bovine) - CCDC175 gene Taurus_UMD|evm.model.AC_000167.1.816 Q5IS59 RTN1_PANTR 86.469 0.997426 1.00129 RTN1 - Reticulon-1 - Pan troglodytes (Chimpanzee) - RTN1 gene Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. Taurus_UMD|evm.model.AC_000167.1.817 Q6ZRR7 LRRC9_HUMAN 89.832 0.953177 1.02891 LRRC9 - Leucine-rich repeat-containing protein 9 - Homo sapiens (Human) - LRRC9 gene Taurus_UMD|evm.model.AC_000167.1.819 Q63HM2 PCX4_HUMAN 82.840 0.99746 1.00768 PCNX4 - Pecanex-like protein 4 - Homo sapiens (Human) - PCNX4 gene Taurus_UMD|evm.model.AC_000167.1.820 Q9Y394 DHRS7_HUMAN 85.619 0.805405 1.09145 DHRS7 - Dehydrogenase/reductase SDR family member 7 precursor - Homo sapiens (Human) - DHRS7 gene membrane Taurus_UMD|evm.model.AC_000167.1.821 O62829 PPM1A_BOVIN 100.000 0.837363 1.1911 PPM1A - Protein phosphatase 1A - Bos taurus (Bovine) - PPM1A gene Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). Taurus_UMD|evm.model.AC_000167.1.822 Q8N1H7 S6OS1_HUMAN 75.908 0.803101 1.09881 SIX6OS1 - Protein SIX6OS1 - Homo sapiens (Human) - SIX6OS1 gene Meiotic protein that localizes to the central element of the synaptonemal complex and is required for chromosome synapsis during meiotic recombination. Required for the appropriate processing of intermediate recombination nodules before crossover formation. Taurus_UMD|evm.model.AC_000167.1.824 O95475 SIX6_HUMAN 97.967 0.991903 1.00407 SIX6 - Homeobox protein SIX6 - Homo sapiens (Human) - SIX6 gene May be involved in eye development. Taurus_UMD|evm.model.AC_000167.1.825 A2D5H2 SIX1_LAGLA 98.944 0.992982 1.00352 SIX1 - Homeobox protein SIX1 - Lagothrix lagotricha (Brown woolly monkey) - SIX1 gene Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development (By similarity). Plays an important role in the development of several organs, including kidney, muscle and inner ear (By similarity). Depending on context, functions as transcriptional repressor or activator (By similarity). Lacks an activation domain, and requires interaction with EYA family members for transcription activation (By similarity). Mediates nuclear translocation of EYA1 and EYA2 (By similarity). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (By similarity). Regulates the expression of numerous genes, including MYC, CCNA1, CCND1 and EZR (By similarity). Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2 (By similarity). Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex (By similarity). During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1 (By similarity). Promotes brown adipocyte differentiation (By similarity). Taurus_UMD|evm.model.AC_000167.1.826 Q9UIU6 SIX4_HUMAN 91.751 0.871705 0.728553 SIX4 - Homeobox protein SIX4 - Homo sapiens (Human) - SIX4 gene Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis. Taurus_UMD|evm.model.AC_000167.1.827 P51948 MAT1_HUMAN 97.735 0.993548 1.00324 MNAT1 - CDK-activating kinase assembly factor MAT1 - Homo sapiens (Human) - MNAT1 gene Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Taurus_UMD|evm.model.AC_000167.1.828 Q3MHN8 TRM5_BOVIN 100.000 0.995984 1.00201 TRMT5 - tRNA (guanine(37)-N1)-methyltransferase - Bos taurus (Bovine) - TRMT5 gene Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. Taurus_UMD|evm.model.AC_000167.1.829 Q8IZM9 S38A6_HUMAN 88.816 0.995624 1.00219 SLC38A6 - Probable sodium-coupled neutral amino acid transporter 6 - Homo sapiens (Human) - SLC38A6 gene Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate. Taurus_UMD|evm.model.AC_000167.1.830 P05786 K2C8_BOVIN 96.462 0.995294 0.889121 KRT8 - Keratin, type II cytoskeletal 8 - Bos taurus (Bovine) - KRT8 gene Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Taurus_UMD|evm.model.AC_000167.1.831 Q3MIR4 CC50B_HUMAN 95.322 0.963277 1.00855 TMEM30B - Cell cycle control protein 50B - Homo sapiens (Human) - TMEM30B gene Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane. Taurus_UMD|evm.model.AC_000167.1.835 Q9XTA5 HIF1A_BOVIN 99.878 0.997573 1.00122 HIF1A - Hypoxia-inducible factor 1-alpha - Bos taurus (Bovine) - HIF1A gene Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (By similarity). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with NCOA1 and/or NCOA2. Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity). Taurus_UMD|evm.model.AC_000167.1.836 Q16533 SNPC1_HUMAN 82.385 0.983871 1.01087 SNAPC1 - snRNA-activating protein complex subunit 1 - Homo sapiens (Human) - SNAPC1 gene Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. Taurus_UMD|evm.model.AC_000167.1.837 Q17RD7 SYT16_HUMAN 74.336 0.888889 0.195349 SYT16 - Synaptotagmin-16 - Homo sapiens (Human) - SYT16 gene May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent. Taurus_UMD|evm.model.AC_000167.1.839 Q17RD7 SYT16_HUMAN 88.747 0.95723 0.76124 SYT16 - Synaptotagmin-16 - Homo sapiens (Human) - SYT16 gene May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent. Taurus_UMD|evm.model.AC_000167.1.840 A6QPD8 U730_BOVIN 100.000 0.285714 3.43137 Putative UPF0730 protein encoded by LINC00643 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000167.1.841 Q8NCM2 KCNH5_HUMAN 99.089 0.997978 1.00101 KCNH5 - Potassium voltage-gated channel subfamily H member 5 - Homo sapiens (Human) - KCNH5 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Taurus_UMD|evm.model.AC_000167.1.842 Q9H4E5 RHOJ_HUMAN 95.794 0.990698 1.00467 RHOJ - Rho-related GTP-binding protein RhoJ precursor - Homo sapiens (Human) - RHOJ gene Plasma membrane-associated small GTPase specifically involved in angiogenesis (PubMed:21628409, PubMed:24434213, PubMed:30158707). Required for endothelial cell migration during vascular development via its interaction with GLUL (PubMed:30158707). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:30158707). Taurus_UMD|evm.model.AC_000167.1.843 Q86YW7 GPHB5_HUMAN 91.538 0.984733 1.00769 GPHB5 - Glycoprotein hormone beta-5 precursor - Homo sapiens (Human) - GPHB5 gene Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. Taurus_UMD|evm.model.AC_000167.1.844 O70374 MTG8R_MOUSE 88.830 0.989418 0.318182 Cbfa2t2 - Protein CBFA2T2 - Mus musculus (Mouse) - Cbfa2t2 gene Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation (PubMed:27281218). Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent mannerCan repress the expression of MMP7 in a ZBTB33-dependent manner (By similarity). Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:19799863). Required for the maintenance of the secretory cell lineage in the small intestine (PubMed:16227606). Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (PubMed:25398765). Taurus_UMD|evm.model.AC_000167.1.845 O43439 MTG8R_HUMAN 88.393 0.770035 0.475166 CBFA2T2 - Protein CBFA2T2 - Homo sapiens (Human) - CBFA2T2 gene Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). Taurus_UMD|evm.model.AC_000167.1.846 Q16537 2A5E_HUMAN 100.000 0.995726 1.00214 PPP2R5E - Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform - Homo sapiens (Human) - PPP2R5E gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Taurus_UMD|evm.model.AC_000167.1.847 Q3ZBK1 WDR89_BOVIN 100.000 0.994832 1.00259 WDR89 - WD repeat-containing protein 89 - Bos taurus (Bovine) - WDR89 gene Taurus_UMD|evm.model.AC_000167.1.848 Q9BX95 SGPP1_HUMAN 78.652 0.995192 0.943311 SGPP1 - Sphingosine-1-phosphate phosphatase 1 - Homo sapiens (Human) - SGPP1 gene Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid (PubMed:16782891). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (PubMed:12815058, PubMed:11756451, PubMed:16782891). Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:11756451, PubMed:12815058, PubMed:16782891). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic retiulum to the Golgi apparatus (PubMed:16782891). The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed:18583713). Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (PubMed:20798685, PubMed:18583713). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity). Taurus_UMD|evm.model.AC_000167.1.849 Q8WXH0 SYNE2_HUMAN 81.007 0.999657 0.84764 SYNE2 - Nesprin-2 - Homo sapiens (Human) - SYNE2 gene Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Taurus_UMD|evm.model.AC_000167.1.850 Q9XSB5 ESR2_BOVIN 91.651 0.99596 0.939279 ESR2 - Estrogen receptor beta - Bos taurus (Bovine) - ESR2 gene Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Taurus_UMD|evm.model.AC_000167.1.851 Q8IYT3 CC170_HUMAN 36.752 0.195286 0.830769 CCDC170 - Coiled-coil domain-containing protein 170 - Homo sapiens (Human) - CCDC170 gene Plays a role in Golgi-associated microtubules organization and stabilization. Taurus_UMD|evm.model.AC_000167.1.852 P11586 C1TC_HUMAN 92.374 0.661451 1.50374 MTHFD1 - C-1-tetrahydrofolate synthase, cytoplasmic - Homo sapiens (Human) - MTHFD1 gene cytosol, extracellular exosome, membrane, mitochondrion, formate-tetrahydrofolate ligase activity, methenyltetrahydrofolate cyclohydrolase activity, methylenetetrahydrofolate dehydrogenase (NAD+) activity, methylenetetrahydrofolate dehydrogenase (NADP+) activity, methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity, 10-formyltetrahydrofolate biosynthetic process Taurus_UMD|evm.model.AC_000167.1.853 A1YEX3 ZBT25_GORGO 94.960 0.959184 0.901149 ZBTB25 - Zinc finger and BTB domain-containing protein 25 - Gorilla gorilla gorilla (Western lowland gorilla) - ZBTB25 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000167.1.854 Q9Y2K1 ZBTB1_HUMAN 98.036 0.997199 1.0014 ZBTB1 - Zinc finger and BTB domain-containing protein 1 - Homo sapiens (Human) - ZBTB1 gene Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity). Taurus_UMD|evm.model.AC_000167.1.855 P34933 HSP72_BOVIN 99.843 0.99686 1.00157 HSPA2 - Heat shock-related 70 kDa protein 2 - Bos taurus (Bovine) - HSPA2 gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells. Taurus_UMD|evm.model.AC_000167.1.856 Q96LQ0 PPR36_HUMAN 77.251 0.995062 0.959716 PPP1R36 - Protein phosphatase 1 regulatory subunit 36 - Homo sapiens (Human) - PPP1R36 gene Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. Taurus_UMD|evm.model.AC_000167.1.857 A1L390 PKHG3_HUMAN 85.684 0.351474 1.08532 PLEKHG3 - Pleckstrin homology domain-containing family G member 3 - Homo sapiens (Human) - PLEKHG3 gene Taurus_UMD|evm.model.AC_000167.1.858 P11277 SPTB1_HUMAN 91.356 0.891397 1.09874 SPTB - Spectrin beta chain, erythrocytic - Homo sapiens (Human) - SPTB gene Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Taurus_UMD|evm.model.AC_000167.1.859 Q2HJG7 CHUR_BOVIN 98.571 0.985816 1.01439 CHURC1 - Protein Churchill - Bos taurus (Bovine) - CHURC1 gene Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement. Does not bind DNA by itself (By similarity). Taurus_UMD|evm.model.AC_000167.1.860 Q9JHC0 GPX2_MOUSE 94.118 0.861314 0.721053 Gpx2 - Glutathione peroxidase 2 - Mus musculus (Mouse) - Gpx2 gene cytosol, glutathione peroxidase activity, peroxidase activity, biological process involved in interaction with symbiont, negative regulation of inflammatory response to antigenic stimulus, response to symbiotic bacterium, temperature homeostasis Taurus_UMD|evm.model.AC_000167.1.861 Q1RMR4 RAB15_BOVIN 100.000 0.99061 1.00472 RAB15 - Ras-related protein Rab-15 - Bos taurus (Bovine) - RAB15 gene May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal. EHBP1L1. Taurus_UMD|evm.model.AC_000167.1.862 P49355 FNTB_BOVIN 100.000 0.995434 1.00229 FNTB - Protein farnesyltransferase subunit beta - Bos taurus (Bovine) - FNTB gene Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X (By similarity). Taurus_UMD|evm.model.AC_000167.1.863 P61244 MAX_HUMAN 99.375 0.987578 1.00625 MAX - Protein max - Homo sapiens (Human) - MAX gene Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. Taurus_UMD|evm.model.AC_000167.1.864 Q9N0W2 FUT8_BOVIN 99.304 0.996528 1.00174 FUT8 - Alpha-(1,6)-fucosyltransferase - Bos taurus (Bovine) - FUT8 gene Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Taurus_UMD|evm.model.AC_000167.1.865 Q3T014 PMGE_BOVIN 97.683 0.992308 1.00386 BPGM - Bisphosphoglycerate mutase - Bos taurus (Bovine) - BPGM gene Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. Taurus_UMD|evm.model.AC_000167.1.866 Q2YDE5 CC196_BOVIN 100.000 0.57047 1.50505 CCDC196 - Putative coiled-coil domain-containing protein 196 - Bos taurus (Bovine) - CCDC196 gene Taurus_UMD|evm.model.AC_000167.1.868 Q2YDE8 FA71D_BOVIN 99.744 0.944175 1.03778 FAM71D - Protein FAM71D - Bos taurus (Bovine) - FAM71D gene Taurus_UMD|evm.model.AC_000167.1.869 E2QY99 MPP5_CANLF 98.815 0.997041 1.00148 PALS1 - Protein PALS1 - Canis lupus familiaris (Dog) - PALS1 gene Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:17182851). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (PubMed:17182851). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). May play a role in the T-cell receptor-mediated activation of NF-kappa-B (By similarity). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). Taurus_UMD|evm.model.AC_000167.1.870 P39942 VATD_BOVIN 99.595 0.991935 1.00405 ATP6V1D - V-type proton ATPase subunit D - Bos taurus (Bovine) - ATP6V1D gene Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). Taurus_UMD|evm.model.AC_000167.1.871 P68101 IF2A_RAT 100.000 0.993671 1.00317 Eif2s1 - Eukaryotic translation initiation factor 2 subunit 1 - Rattus norvegicus (Rat) - Eif2s1 gene Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. EIF2S1/eIF-2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming. Taurus_UMD|evm.model.AC_000167.1.872 Q9NYT0 PLEK2_HUMAN 94.334 0.99435 1.00283 PLEK2 - Pleckstrin-2 - Homo sapiens (Human) - PLEK2 gene May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. Taurus_UMD|evm.model.AC_000167.1.873 Q5EA70 T229B_BOVIN 100.000 0.988095 1.00599 TMEM229B - Transmembrane protein 229B - Bos taurus (Bovine) - TMEM229B gene Taurus_UMD|evm.model.AC_000167.1.875 Q9ULM0 PKHH1_HUMAN 86.813 0.998529 0.997067 PLEKHH1 - Pleckstrin homology domain-containing family H member 1 - Homo sapiens (Human) - PLEKHH1 gene Taurus_UMD|evm.model.AC_000167.1.876 Q32L89 PIGH_BOVIN 98.936 0.939698 1.05851 PIGH - Phosphatidylinositol N-acetylglucosaminyltransferase subunit H - Bos taurus (Bovine) - PIGH gene Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Taurus_UMD|evm.model.AC_000167.1.877 Q58DL1 ARGI2_BOVIN 99.718 0.994366 1.00282 ARG2 - Arginase-2, mitochondrial precursor - Bos taurus (Bovine) - ARG2 gene May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity. Taurus_UMD|evm.model.AC_000167.1.878 Q2KIU0 VTI1B_BOVIN 99.569 0.991416 1.00431 VTI1B - Vesicle transport through interaction with t-SNAREs homolog 1B - Bos taurus (Bovine) - VTI1B gene V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. Taurus_UMD|evm.model.AC_000167.1.879 Q8TC12 RDH11_HUMAN 89.109 0.88563 1.07233 RDH11 - Retinol dehydrogenase 11 - Homo sapiens (Human) - RDH11 gene Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956). Taurus_UMD|evm.model.AC_000167.1.880 P59837 RDH12_BOVIN 99.320 0.811634 1.14241 RDH12 - Retinol dehydrogenase 12 - Bos taurus (Bovine) - RDH12 gene Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards steroids. Taurus_UMD|evm.model.AC_000167.1.881 E1BLZ4 ZFY26_BOVIN 98.975 0.99921 1.00676 ZFYVE26 - Zinc finger FYVE domain-containing protein 26 - Bos taurus (Bovine) - ZFYVE26 gene Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity). Taurus_UMD|evm.model.AC_000167.1.882 O15315 RA51B_HUMAN 82.370 0.980769 0.8125 RAD51B - DNA repair protein RAD51 homolog 2 - Homo sapiens (Human) - RAD51B gene Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Taurus_UMD|evm.model.AC_000167.1.884 Q07352 TISB_HUMAN 99.112 0.9941 1.00296 ZFP36L1 - mRNA decay activator protein ZFP36L1 - Homo sapiens (Human) - ZFP36L1 gene Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity). Taurus_UMD|evm.model.AC_000167.1.885 P52301 RAN_XENLA 66.964 0.946429 0.518519 ran - GTP-binding nuclear protein Ran - Xenopus laevis (African clawed frog) - ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:8413630). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446). Required for normal progress through mitosis (By similarity). In concert with nemp1a/b, required for proper eye development (PubMed:25946333). Taurus_UMD|evm.model.AC_000167.1.886 Q3B7N2 ACTN1_BOVIN 97.593 0.997814 1.02578 ACTN1 - Alpha-actinin-1 - Bos taurus (Bovine) - ACTN1 gene F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). Taurus_UMD|evm.model.AC_000167.1.887 Q96JK2 DCAF5_HUMAN 87.977 0.997599 0.884289 DCAF5 - DDB1- and CUL4-associated factor 5 - Homo sapiens (Human) - DCAF5 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Taurus_UMD|evm.model.AC_000167.1.888 Q9NVH0 EXD2_HUMAN 89.793 0.993641 1.01288 EXD2 - Exonuclease 3'-5' domain-containing protein 2 - Homo sapiens (Human) - EXD2 gene Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291). In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:29335528, PubMed:31127291). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528). Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466). Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646). Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646). Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466). Taurus_UMD|evm.model.AC_000167.1.890 Q8N428 GLT16_HUMAN 93.728 0.996416 1 GALNT16 - Polypeptide N-acetylgalactosaminyltransferase 16 - Homo sapiens (Human) - GALNT16 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Taurus_UMD|evm.model.AC_000167.1.891 P84089 ERH_MOUSE 100.000 0.980952 1.00962 Erh - Enhancer of rudimentary homolog - Mus musculus (Mouse) - Erh gene May have a role in the cell cycle. Taurus_UMD|evm.model.AC_000167.1.893 Q9NUM3 S39A9_HUMAN 95.440 0.993506 1.00326 SLC39A9 - Zinc transporter ZIP9 - Homo sapiens (Human) - SLC39A9 gene May act as a zinc-influx transporter. Taurus_UMD|evm.model.AC_000167.1.894 A6NEE1 PLHD1_HUMAN 91.700 0.99596 0.978261 PLEKHD1 - Pleckstrin homology domain-containing family D member 1 - Homo sapiens (Human) - PLEKHD1 gene Taurus_UMD|evm.model.AC_000167.1.895 Q9NQR7 CC177_HUMAN 90.523 0.997139 0.988685 CCDC177 - Coiled-coil domain-containing protein 177 - Homo sapiens (Human) - CCDC177 gene Taurus_UMD|evm.model.AC_000167.1.896 Q92537 SUSD6_HUMAN 91.749 0.993355 0.993399 SUSD6 - Sushi domain-containing protein 6 precursor - Homo sapiens (Human) - SUSD6 gene May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity). Taurus_UMD|evm.model.AC_000167.1.898 Q13243 SRSF5_HUMAN 98.540 0.992674 1.00368 SRSF5 - Serine/arginine-rich splicing factor 5 - Homo sapiens (Human) - SRSF5 gene Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Taurus_UMD|evm.model.AC_000167.1.899 Q14973 NTCP_HUMAN 83.478 0.927224 1.06304 SLC10A1 - Sodium/bile acid cotransporter - Homo sapiens (Human) - SLC10A1 gene The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Taurus_UMD|evm.model.AC_000167.1.900 Q9H4F8 SMOC1_HUMAN 96.092 0.995413 1.00461 SMOC1 - SPARC-related modular calcium-binding protein 1 precursor - Homo sapiens (Human) - SMOC1 gene Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation. Taurus_UMD|evm.model.AC_000167.1.901 S4R2P9 NAC3_MOUSE 93.750 0.83715 0.423491 Slc8a3 - Sodium/calcium exchanger 3 precursor - Mus musculus (Mouse) - Slc8a3 gene Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain (PubMed:14722618, PubMed:21593315). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:14722618, PubMed:21593315). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:14722618). In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (PubMed:21593315). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (PubMed:24616101). Isoform 1 displays higher calcium exchanger activity than isoform 2, probably because isoform 1 has a lower threshold for activation by cytoplasmic Ca(2+) (PubMed:24616101). Taurus_UMD|evm.model.AC_000167.1.902 Q6UWI4 SHSA2_HUMAN 54.000 0.842593 0.366102 SHISA2 - Protein shisa-2 homolog precursor - Homo sapiens (Human) - SHISA2 gene Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Taurus_UMD|evm.model.AC_000167.1.903 P57103 NAC3_HUMAN 97.143 0.996644 0.642934 SLC8A3 - Sodium/calcium exchanger 3 precursor - Homo sapiens (Human) - SLC8A3 gene Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity). Taurus_UMD|evm.model.AC_000167.1.904 Q3T0C9 SYJ2B_BOVIN 99.310 0.986301 1.0069 SYNJ2BP - Synaptojanin-2-binding protein - Bos taurus (Bovine) - SYNJ2BP gene Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction. Taurus_UMD|evm.model.AC_000167.1.905 Q2NKS2 COX16_BOVIN 100.000 0.981481 1.00935 COX16 - Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial - Bos taurus (Bovine) - COX16 gene Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6. Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines. Taurus_UMD|evm.model.AC_000167.1.906 Q9JI76 ADA21_MOUSE 46.154 0.533058 0.331962 Adam21 - Disintegrin and metalloproteinase domain-containing protein 21 precursor - Mus musculus (Mouse) - Adam21 gene May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. Taurus_UMD|evm.model.AC_000167.1.907 O43506 ADA20_HUMAN 48.175 0.235702 0.794766 ADAM20 - Disintegrin and metalloproteinase domain-containing protein 20 precursor - Homo sapiens (Human) - ADAM20 gene May be involved in sperm maturation and/or fertilization. Taurus_UMD|evm.model.AC_000167.1.908 Q9UKJ8 ADA21_HUMAN 73.826 0.968144 1 ADAM21 - Disintegrin and metalloproteinase domain-containing protein 21 precursor - Homo sapiens (Human) - ADAM21 gene May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. Taurus_UMD|evm.model.AC_000167.1.909 O43506 ADA20_HUMAN 70.554 0.899604 1.0427 ADAM20 - Disintegrin and metalloproteinase domain-containing protein 20 precursor - Homo sapiens (Human) - ADAM20 gene May be involved in sperm maturation and/or fertilization. Taurus_UMD|evm.model.AC_000167.1.910 Q3SZY9 MED6_BOVIN 100.000 0.991903 1.00407 MED6 - Mediator of RNA polymerase II transcription subunit 6 - Bos taurus (Bovine) - MED6 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Taurus_UMD|evm.model.AC_000167.1.911 Q92623 TTC9A_HUMAN 96.226 0.822917 0.864865 TTC9 - Tetratricopeptide repeat protein 9A - Homo sapiens (Human) - TTC9 gene Taurus_UMD|evm.model.AC_000167.1.912 P80192 M3K9_HUMAN 96.380 0.998188 1 MAP3K9 - Mitogen-activated protein kinase kinase kinase 9 - Homo sapiens (Human) - MAP3K9 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Taurus_UMD|evm.model.AC_000167.1.914 Q96RV3 PCX1_HUMAN 96.586 0.661176 0.907732 PCNX1 - Pecanex-like protein 1 - Homo sapiens (Human) - PCNX1 gene Taurus_UMD|evm.model.AC_000167.1.915 Q58DT1 RL7_BOVIN 89.908 0.877049 0.491935 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Taurus_UMD|evm.model.AC_000167.1.916 Q58DT1 RL7_BOVIN 95.283 0.972222 0.435484 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Taurus_UMD|evm.model.AC_000167.1.918 P30050 RL12_HUMAN 100.000 0.987952 1.00606 RPL12 - 60S ribosomal protein L12 - Homo sapiens (Human) - RPL12 gene Binds directly to 26S ribosomal RNA. Taurus_UMD|evm.model.AC_000167.1.919 O43166 SI1L1_HUMAN 96.842 0.998893 1.00111 SIPA1L1 - Signal-induced proliferation-associated 1-like protein 1 - Homo sapiens (Human) - SIPA1L1 gene Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). Taurus_UMD|evm.model.AC_000167.1.920 P49758 RGS6_HUMAN 94.286 0.995927 1.04025 RGS6 - Regulator of G-protein signaling 6 - Homo sapiens (Human) - RGS6 gene Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). Taurus_UMD|evm.model.AC_000167.1.921 P58269 DPF3_MOUSE 97.015 0.741573 0.23545 Dpf3 - Zinc finger protein DPF3 - Mus musculus (Mouse) - Dpf3 gene Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development (By similarity). Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Taurus_UMD|evm.model.AC_000167.1.923 Q92784 DPF3_HUMAN 96.233 0.812849 0.94709 DPF3 - Zinc finger protein DPF3 - Homo sapiens (Human) - DPF3 gene Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development. Taurus_UMD|evm.model.AC_000167.1.924 Q5R938 RS15A_PONAB 97.692 0.984733 1.00769 RPS15A - 40S ribosomal protein S15a - Pongo abelii (Sumatran orangutan) - RPS15A gene Structural component of the ribosome. Required for proper erythropoiesis. Taurus_UMD|evm.model.AC_000167.1.925 Q58DC2 DCAF4_BOVIN 98.785 0.99596 1.00202 DCAF4 - DDB1- and CUL4-associated factor 4 - Bos taurus (Bovine) - DCAF4 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Taurus_UMD|evm.model.AC_000167.1.926 Q810J8 ZFYV1_MOUSE 96.654 0.997429 1.00129 Zfyve1 - Zinc finger FYVE domain-containing protein 1 - Mus musculus (Mouse) - Zfyve1 gene Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241). Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contact sites by forming a complex with RAB18 and ZW10 (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (By similarity). Taurus_UMD|evm.model.AC_000167.1.927 P49756 RBM25_HUMAN 99.881 0.99763 1.00119 RBM25 - RNA-binding protein 25 - Homo sapiens (Human) - RBM25 gene RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. Taurus_UMD|evm.model.AC_000167.1.928 Q9XT97 PSN1_BOVIN 97.699 0.886148 1.10251 PSEN1 - Presenilin-1 - Bos taurus (Bovine) - PSEN1 gene Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (By similarity). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (By similarity). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis. Involved in the regulation of neurite outgrowth (By similarity). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity). Taurus_UMD|evm.model.AC_000167.1.930 O95428 PPN_HUMAN 75.473 0.980424 0.959311 PAPLN - Papilin precursor - Homo sapiens (Human) - PAPLN gene extracellular matrix, metalloendopeptidase activity, extracellular matrix organization Taurus_UMD|evm.model.AC_000167.1.931 P49757 NUMB_HUMAN 88.208 0.996764 0.949309 NUMB - Protein numb homolog - Homo sapiens (Human) - NUMB gene Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). Taurus_UMD|evm.model.AC_000167.1.932 Q86WZ0 HEAT4_HUMAN 75.522 0.971872 1.00487 HEATR4 - HEAT repeat-containing protein 4 - Homo sapiens (Human) - HEATR4 gene oxidoreductase activity Taurus_UMD|evm.model.AC_000167.1.933 Q86TX2 ACOT1_HUMAN 83.848 0.903226 1.10451 ACOT1 - Acyl-coenzyme A thioesterase 1 - Homo sapiens (Human) - ACOT1 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating intracellular levels of acyl-CoAs, free fatty acids and CoASH. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20). Taurus_UMD|evm.model.AC_000167.1.934 Q8N9L9 ACOT4_HUMAN 82.892 0.974118 1.0095 ACOT4 - Peroxisomal succinyl-coenzyme A thioesterase - Homo sapiens (Human) - ACOT4 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16940157). ACOT4 is a peroxisomal succinyl-coenzyme A thioesterase can also hydrolyze glutaryl-CoA and long chain saturated acyl-CoAs (PubMed:16940157). Taurus_UMD|evm.model.AC_000167.1.935 Q86TX2 ACOT1_HUMAN 81.710 0.995261 1.00238 ACOT1 - Acyl-coenzyme A thioesterase 1 - Homo sapiens (Human) - ACOT1 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating intracellular levels of acyl-CoAs, free fatty acids and CoASH. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20). Taurus_UMD|evm.model.AC_000167.1.936 Q5VVW2 GARL3_HUMAN 85.448 0.747899 0.352419 GARNL3 - GTPase-activating Rap/Ran-GAP domain-like protein 3 - Homo sapiens (Human) - GARNL3 gene cytoplasm, GTPase activator activity, activation of GTPase activity Taurus_UMD|evm.model.AC_000167.1.937 Q8N9L9 ACOT4_HUMAN 82.410 0.992806 0.990499 ACOT4 - Peroxisomal succinyl-coenzyme A thioesterase - Homo sapiens (Human) - ACOT4 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16940157). ACOT4 is a peroxisomal succinyl-coenzyme A thioesterase can also hydrolyze glutaryl-CoA and long chain saturated acyl-CoAs (PubMed:16940157). Taurus_UMD|evm.model.AC_000167.1.938 Q32Q92 ACOT6_MOUSE 72.986 0.995261 1.00716 Acot6 - Acyl-coenzyme A thioesterase 6 - Mus musculus (Mouse) - Acot6 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:17613526). Acyl-coenzyme A thioesterase 6/ACOT6 catalyzes the hydrolysis of phytanoyl-CoA and pristanoyl-CoA, two methyl-branched fatty acids derived from phytol, that enter the body via the diet (PubMed:17613526). Taurus_UMD|evm.model.AC_000167.1.939 Q02543 RL18A_HUMAN 90.909 0.988166 0.960227 RPL18A - 60S ribosomal protein L18a - Homo sapiens (Human) - RPL18A gene cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, polysomal ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, rRNA processing Taurus_UMD|evm.model.AC_000167.1.940 Q2KID4 DNAL1_BOVIN 100.000 0.989529 1.00526 DNAL1 - Dynein axonemal light chain 1 - Bos taurus (Bovine) - DNAL1 gene Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (By similarity). Taurus_UMD|evm.model.AC_000167.1.941 A6QLK5 PNMA1_BOVIN 100.000 0.99435 1.00283 PNMA1 - Paraneoplastic antigen Ma1 homolog - Bos taurus (Bovine) - PNMA1 gene cytoplasm, nucleolus, inflammatory response to antigenic stimulus Taurus_UMD|evm.model.AC_000167.1.942 Q6PJG2 MDEAS_HUMAN 89.279 0.945603 1.0555 MIDEAS - Mitotic deacetylase-associated SANT domain protein - Homo sapiens (Human) - MIDEAS gene histone deacetylase complex, nucleoplasm, transcription regulator complex, transcription corepressor activity, histone deacetylation, negative regulation of transcription, DNA-templated, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000167.1.944 Q32L99 PTGR2_BOVIN 100.000 0.994318 1.00285 PTGR2 - Prostaglandin reductase 2 - Bos taurus (Bovine) - PTGR2 gene Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Taurus_UMD|evm.model.AC_000167.1.945 Q5EAC5 ZN410_BOVIN 97.699 0.995825 1.0257 ZNF410 - Zinc finger protein 410 - Bos taurus (Bovine) - ZNF410 gene Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence. Taurus_UMD|evm.model.AC_000167.1.946 Q96MY7 F161B_HUMAN 77.231 0.996928 1.00618 FAM161B - Protein FAM161B - Homo sapiens (Human) - FAM161B gene cytoplasmic microtubule, microtubule cytoskeleton, cilium organization Taurus_UMD|evm.model.AC_000167.1.947 Q2KIL4 COQ6_BOVIN 100.000 0.995745 1.00213 COQ6 - Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial precursor - Bos taurus (Bovine) - COQ6 gene FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. Taurus_UMD|evm.model.AC_000167.1.948 E1BPW0 ENTP5_BOVIN 99.074 0.995338 0.993056 ENTPD5 - Ectonucleoside triphosphate diphosphohydrolase 5 precursor - Bos taurus (Bovine) - ENTPD5 gene Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling (By similarity). Taurus_UMD|evm.model.AC_000167.1.949 Q8ND07 BBOF1_HUMAN 81.621 0.928309 1.02836 BBOF1 - Basal body-orientation factor 1 - Homo sapiens (Human) - BBOF1 gene Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity). Taurus_UMD|evm.model.AC_000167.1.950 Q07536 MMSA_BOVIN 99.628 0.996283 1.00186 ALDH6A1 - Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor - Bos taurus (Bovine) - ALDH6A1 gene Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. Taurus_UMD|evm.model.AC_000167.1.951 Q8CD94 LIN52_MOUSE 100.000 0.982906 1.00862 Lin52 - Protein lin-52 homolog - Mus musculus (Mouse) - Lin52 gene Taurus_UMD|evm.model.AC_000167.1.952 P58304 VSX2_HUMAN 92.521 0.994475 1.00277 VSX2 - Visual system homeobox 2 - Homo sapiens (Human) - VSX2 gene Acts as a transcriptional regulator through binding to DNA at the consensus sequence 5'-[TC]TAATT[AG][AG]-3' upstream of gene promoters (PubMed:27301076). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex, such as VSX1 (PubMed:17919464, PubMed:27477290). Acts as a positive transcriptional regulator of NXNL1; regulation is significantly increased in synergy with VSX1 (By similarity). Acts as a negative transcriptional regulator of MITF (By similarity). Represses SAG transcription by competitive inhibition of ISL1-LHX3 response elements (PubMed:16236706, PubMed:27477290). Binds to the photoreceptor conserved element-1 (PCE-1) in the promoter of rod photoreceptor arrestin SAG and acts as a transcriptional repressor (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Involved in the development of retinal ganglion cells (RGCs) which leads to release of SHH by RGCs, promoting Hedgehog signaling and subsequent proliferation of retinal progenitor cells (By similarity). Participates in the development of the cells of the inner nuclear layer, by promoting postnatal differentiation of bipolar cells with a comparable inhibition of rod cell differentiation (By similarity). May play a role in the maintenance of neural retina identity during development by regulation of canonical Wnt genes and CTNNB1 localization, suggesting a role in the regulation of canonical Wnt signaling (PubMed:27301076). Taurus_UMD|evm.model.AC_000167.1.953 O14678 ABCD4_HUMAN 89.439 0.996705 1.00165 ABCD4 - Lysosomal cobalamin transporter ABCD4 - Homo sapiens (Human) - ABCD4 gene Lysosomal transporter that plays a role in the lysosomal release of vitamin B12 into the cytosol (PubMed:22922874). Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane (PubMed:27456980). Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791). Taurus_UMD|evm.model.AC_000167.1.954 E1BP92 VRTN_BOVIN 93.857 0.997147 1.06535 VRTN - Vertnin - Bos taurus (Bovine) - VRTN gene Taurus_UMD|evm.model.AC_000167.1.955 A4IFJ1 SYN1L_BOVIN 99.580 0.991632 1.0042 SYNDIG1L - Synapse differentiation-inducing gene protein 1-like - Bos taurus (Bovine) - SYNDIG1L gene Taurus_UMD|evm.model.AC_000167.1.956 P79345 NPC2_BOVIN 100.000 0.986667 1.00671 NPC2 - NPC intracellular cholesterol transporter 2 precursor - Bos taurus (Bovine) - NPC2 gene Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:29580834, PubMed:17552909). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (By similarity). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17573352). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity). Taurus_UMD|evm.model.AC_000167.1.957 Q2TBG7 ISCA2_BOVIN 99.346 0.987013 1.01316 ISCA2 - Iron-sulfur cluster assembly 2 homolog, mitochondrial precursor - Bos taurus (Bovine) - ISCA2 gene Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly. Taurus_UMD|evm.model.AC_000167.1.958 Q28019 LTBP2_BOVIN 98.208 0.936434 1.05049 LTBP2 - Latent-transforming growth factor beta-binding protein 2 precursor - Bos taurus (Bovine) - LTBP2 gene May play an integral structural role in elastic-fiber architectural organization and/or assembly. Taurus_UMD|evm.model.AC_000167.1.959 O15033 AREL1_HUMAN 97.205 0.997573 1.00122 AREL1 - Apoptosis-resistant E3 ubiquitin protein ligase 1 - Homo sapiens (Human) - AREL1 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation (PubMed:23479728). Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome (PubMed:31578312). Taurus_UMD|evm.model.AC_000167.1.960 Q5RFQ0 FCF1_PONAB 100.000 0.98995 1.00505 FCF1 - rRNA-processing protein FCF1 homolog - Pongo abelii (Sumatran orangutan) - FCF1 gene Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. Taurus_UMD|evm.model.AC_000167.1.961 Q9R0I7 YLPM1_MOUSE 95.263 0.0880708 1.54834 Ylpm1 - YLP motif-containing protein 1 - Mus musculus (Mouse) - Ylpm1 gene Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation. Taurus_UMD|evm.model.AC_000167.1.962 Q3B8N5 PROX2_HUMAN 75.197 0.629333 0.633446 PROX2 - Prospero homeobox protein 2 - Homo sapiens (Human) - PROX2 gene Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). Taurus_UMD|evm.model.AC_000167.1.963 P11179 ODO2_BOVIN 91.522 0.856061 1.16044 DLST - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor - Bos taurus (Bovine) - DLST gene Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity). Taurus_UMD|evm.model.AC_000167.1.964 Q5RA67 RPKL1_PONAB 78.040 0.99637 1.00364 RPS6KL1 - Ribosomal protein S6 kinase-like 1 - Pongo abelii (Sumatran orangutan) - RPS6KL1 gene Taurus_UMD|evm.model.AC_000167.1.965 Q9XS47 PLGF_BOVIN 87.647 0.988304 1.14765 PGF - Placenta growth factor precursor - Bos taurus (Bovine) - PGF gene Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth (By similarity). Taurus_UMD|evm.model.AC_000167.1.966 Q5E9B4 EI2BB_BOVIN 100.000 0.994318 1.00285 EIF2B2 - Translation initiation factor eIF-2B subunit beta - Bos taurus (Bovine) - EIF2B2 gene Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Taurus_UMD|evm.model.AC_000167.1.967 Q9UHC1 MLH3_HUMAN 79.917 0.945875 1.04267 MLH3 - DNA mismatch repair protein Mlh3 - Homo sapiens (Human) - MLH3 gene Probably involved in the repair of mismatches in DNA. Taurus_UMD|evm.model.AC_000167.1.968 P41500 ACYP1_BOVIN 100.000 0.625 1.58416 ACYP1 - Acylphosphatase-1 - Bos taurus (Bovine) - ACYP1 gene acylphosphatase activity Taurus_UMD|evm.model.AC_000167.1.969 Q9BGW4 ZC21C_MACFA 72.795 0.996234 1 ZC2HC1C - Zinc finger C2HC domain-containing protein 1C - Macaca fascicularis (Crab-eating macaque) - ZC2HC1C gene Taurus_UMD|evm.model.AC_000167.1.970 Q8TD19 NEK9_HUMAN 96.221 0.997955 0.998979 NEK9 - Serine/threonine-protein kinase Nek9 - Homo sapiens (Human) - NEK9 gene Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively. Taurus_UMD|evm.model.AC_000167.1.971 Q90515 TMEDA_TAKRU 94.253 0.544304 0.741784 tmed10 - Transmembrane emp24 domain-containing protein 10 precursor - Takifugu rubripes (Japanese pufferfish) - tmed10 gene Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity). Taurus_UMD|evm.model.AC_000167.1.972 O77628 FOS_BOVIN 100.000 0.994751 1.00263 FOS - Proto-oncogene c-Fos - Bos taurus (Bovine) - FOS gene Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity). Taurus_UMD|evm.model.AC_000167.1.973 P04773 GLNA_CRIGR 82.927 0.333333 0.313673 GLUL - Glutamine synthetase - Cricetulus griseus (Chinese hamster) - GLUL gene Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). Taurus_UMD|evm.model.AC_000167.1.974 Q8WYK2 JDP2_HUMAN 97.546 0.576512 1.72393 JDP2 - Jun dimerization protein 2 - Homo sapiens (Human) - JDP2 gene Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. Taurus_UMD|evm.model.AC_000167.1.975 D4A7E1 BATF_RAT 92.754 0.747253 0.728 Batf - Basic leucine zipper transcriptional factor ATF-like - Rattus norvegicus (Rat) - Batf gene AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity). Taurus_UMD|evm.model.AC_000167.1.976 Q91X85 FLVC2_MOUSE 79.186 0.44332 0.896552 Flvcr2 - Feline leukemia virus subgroup C receptor-related protein 2 - Mus musculus (Mouse) - Flvcr2 gene Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism (By similarity). Taurus_UMD|evm.model.AC_000167.1.977 Q96DR4 STAR4_HUMAN 88.780 0.976077 1.01951 STARD4 - StAR-related lipid transfer protein 4 - Homo sapiens (Human) - STARD4 gene Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols. Taurus_UMD|evm.model.AC_000167.1.978 P13234 KCC4_RAT 98.000 0.902174 0.582278 Camk4 - Calcium/calmodulin-dependent protein kinase type IV - Rattus norvegicus (Rat) - Camk4 gene Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18 (By similarity). Taurus_UMD|evm.model.AC_000167.1.979 Q8NI36 WDR36_HUMAN 92.514 0.997768 0.942166 WDR36 - WD repeat-containing protein 36 - Homo sapiens (Human) - WDR36 gene Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2. Taurus_UMD|evm.model.AC_000167.1.980 Q969D9 TSLP_HUMAN 55.000 0.418675 2.08805 TSLP - Thymic stromal lymphopoietin precursor - Homo sapiens (Human) - TSLP gene Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. Taurus_UMD|evm.model.AC_000167.1.981 Q9ERY9 ERG28_MOUSE 82.292 0.411255 1.65 Erg28 - Ergosterol biosynthetic protein 28 homolog - Mus musculus (Mouse) - Erg28 gene endoplasmic reticulum, transport vesicle, identical protein binding, protein-macromolecule adaptor activity Taurus_UMD|evm.model.AC_000167.1.982 Q91X85 FLVC2_MOUSE 80.778 0.877016 0.900181 Flvcr2 - Feline leukemia virus subgroup C receptor-related protein 2 - Mus musculus (Mouse) - Flvcr2 gene Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism (By similarity). Taurus_UMD|evm.model.AC_000167.1.983 Q9ERY9 ERG28_MOUSE 89.286 0.985816 1.00714 Erg28 - Ergosterol biosynthetic protein 28 homolog - Mus musculus (Mouse) - Erg28 gene endoplasmic reticulum, transport vesicle, identical protein binding, protein-macromolecule adaptor activity Taurus_UMD|evm.model.AC_000167.1.984 Q5R978 TTLL5_PONAB 91.629 0.997715 1.01078 TTLL5 - Tubulin polyglutamylase TTLL5 - Pongo abelii (Sumatran orangutan) - TTLL5 gene Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (By similarity). Taurus_UMD|evm.model.AC_000167.1.985 P15203 TGFB3_PIG 94.132 0.898455 1.10758 TGFB3 - Transforming growth factor beta-3 proprotein precursor - Sus scrofa (Pig) - TGFB3 gene Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Taurus_UMD|evm.model.AC_000167.1.986 Q2TBN9 IFT43_BOVIN 99.517 0.990385 1.00483 IFT43 - Intraflagellar transport protein 43 homolog - Bos taurus (Bovine) - IFT43 gene As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base. Taurus_UMD|evm.model.AC_000167.1.988 Q9NWQ4 GPT2L_HUMAN 91.134 0.813675 1.21369 GPATCH2L - G patch domain-containing protein 2-like - Homo sapiens (Human) - GPATCH2L gene Taurus_UMD|evm.model.AC_000167.1.989 O95718 ERR2_HUMAN 98.222 0.625698 0.82679 ESRRB - Steroid hormone receptor ERR2 - Homo sapiens (Human) - ESRRB gene Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (PubMed:17920186, PubMed:19755138). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:23836911). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (PubMed:17920186, PubMed:19755138). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity). Taurus_UMD|evm.model.AC_000167.1.990 Q7L8A9 VASH1_HUMAN 94.521 0.994505 0.99726 VASH1 - Tubulinyl-Tyr carboxypeptidase 1 - Homo sapiens (Human) - VASH1 gene Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869, PubMed:31270470, PubMed:31235910, PubMed:31171830, PubMed:31235911). Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:15467828, PubMed:16488400, PubMed:16707096, PubMed:19204325). This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (PubMed:15467828, PubMed:16488400, PubMed:16707096). Taurus_UMD|evm.model.AC_000167.1.991 Q9UNK9 ANGE1_HUMAN 90.909 0.99701 0.998507 ANGEL1 - Protein angel homolog 1 - Homo sapiens (Human) - ANGEL1 gene cis-Golgi network, cytosol, endoplasmic reticulum, nucleus, perinuclear region of cytoplasm, 3'-5'-exoribonuclease activity, eukaryotic initiation factor 4E binding, protein domain specific binding Taurus_UMD|evm.model.AC_000167.1.992 A0JPI9 LR74A_RAT 75.699 0.868421 1.11065 Lrrc74a - Leucine-rich repeat-containing protein 74A - Rattus norvegicus (Rat) - Lrrc74a gene Taurus_UMD|evm.model.AC_000167.1.993 Q2MJS2 I2BPL_MACMU 95.718 0.997419 0.976071 IRF2BPL - Probable E3 ubiquitin-protein ligase IRF2BPL - Macaca mulatta (Rhesus macaque) - IRF2BPL gene Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway. Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). Taurus_UMD|evm.model.AC_000167.1.994 Q5R8C5 CIPC_PONAB 86.466 0.994987 1 CIPC - CLOCK-interacting pacemaker - Pongo abelii (Sumatran orangutan) - CIPC gene Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock. Taurus_UMD|evm.model.AC_000167.1.995 Q8N966 ZDH22_HUMAN 95.057 0.992424 1.0038 ZDHHC22 - Palmitoyltransferase ZDHHC22 - Homo sapiens (Human) - ZDHHC22 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (PubMed:22399288). Catalyzes the palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane (PubMed:22399288). Might also mediate palmitoylation of CNN3 (By similarity). Taurus_UMD|evm.model.AC_000167.1.996 Q9P1W3 CSC1_HUMAN 82.010 0.997516 0.998759 TMEM63C - Calcium permeable stress-gated cation channel 1 - Homo sapiens (Human) - TMEM63C gene Acts as an osmosensitive calcium-permeable cation channel (PubMed:24503647). Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). Taurus_UMD|evm.model.AC_000167.1.997 Q6WZ19 NGB_BOVIN 100.000 0.986842 1.00662 NGB - Neuroglobin - Bos taurus (Bovine) - NGB gene Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes (By similarity). Taurus_UMD|evm.model.AC_000167.1.998 Q9UKY4 POMT2_HUMAN 90.957 0.912515 1.09733 POMT2 - Protein O-mannosyl-transferase 2 - Homo sapiens (Human) - POMT2 gene Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (PubMed:14699049, PubMed:28512129). Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins (PubMed:28512129). Taurus_UMD|evm.model.AC_000167.1.999 P57113 MAAI_RAT 78.603 0.987013 1.06944 Gstz1 - Maleylacetoacetate isomerase - Rattus norvegicus (Rat) - Gstz1 gene Probable bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with t-butyl and cumene hydroperoxides (By similarity). Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. Taurus_UMD|evm.model.AC_000167.1.1000 Q6PL24 TMED8_HUMAN 84.969 0.993884 1.00615 TMED8 - Protein TMED8 - Homo sapiens (Human) - TMED8 gene Taurus_UMD|evm.model.AC_000167.1.1001 Q9P1V8 SAM15_HUMAN 47.665 0.997085 1.0178 SAMD15 - Sterile alpha motif domain-containing protein 15 - Homo sapiens (Human) - SAMD15 gene Taurus_UMD|evm.model.AC_000167.1.1002 Q6NXP6 NXRD1_HUMAN 68.937 0.940722 1.08078 NOXRED1 - NADP-dependent oxidoreductase domain-containing protein 1 - Homo sapiens (Human) - NOXRED1 gene Probable oxidoreductase. Taurus_UMD|evm.model.AC_000167.1.1003 A5D796 SPE39_BOVIN 97.764 0.995943 1.02495 VIPAS39 - Spermatogenesis-defective protein 39 homolog - Bos taurus (Bovine) - VIPAS39 gene Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B. May play a role in vesicular trafficking during spermatogenesis. May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity). Taurus_UMD|evm.model.AC_000167.1.1004 O95433 AHSA1_HUMAN 96.450 0.9941 1.00296 AHSA1 - Activator of 90 kDa heat shock protein ATPase homolog 1 - Homo sapiens (Human) - AHSA1 gene Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Taurus_UMD|evm.model.AC_000167.1.1005 Q8QFV1 ISM_XENLA 49.669 0.359801 0.89755 ism1 - Isthmin precursor - Xenopus laevis (African clawed frog) - ism1 gene May act as an angiogenesis inhibitor. Taurus_UMD|evm.model.AC_000167.1.1007 O15270 SPTC2_HUMAN 94.671 0.996448 1.00178 SPTLC2 - Serine palmitoyltransferase 2 - Homo sapiens (Human) - SPTLC2 gene Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis (By similarity). Taurus_UMD|evm.model.AC_000167.1.1008 Q13686 ALKB1_HUMAN 86.856 0.992308 1.00257 ALKBH1 - Nucleic acid dioxygenase ALKBH1 - Homo sapiens (Human) - ALKBH1 gene Dioxygenase that acts as on nucleic acids, such as DNA and tRNA (PubMed:18603530, PubMed:27745969, PubMed:27497299). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:18603530, PubMed:27497299). A number of activities have been described for this dioxygenase, but recent results suggest that it mainly acts as on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment (PubMed:27745969, PubMed:27497299). Mainly acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs, with a preference for N(1)-methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs (PubMed:27745969). Acts as a regulator of translation initiation and elongation in response to glucose deprivation: regulates both translation initiation, by mediating demethylation of tRNA(Met), and translation elongation, N(1)-methyladenine-containing tRNAs being preferentially recruited to polysomes to promote translation elongation (PubMed:27745969). In mitochondrion, specifically interacts with mt-tRNA(Met) and mediates oxidation of mt-tRNA(Met) methylated at cytosine(34) to form 5-formylcytosine (f(5)c) at this position (PubMed:27497299). mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299). Specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA (PubMed:30392959, PubMed:30017583). N(6)-methyladenosine (m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing (By similarity). Demethylates mRNAs containing N(3)-methylcytidine modification (PubMed:31188562). Also able to repair alkylated single-stranded DNA by oxidative demethylation, but with low activity (PubMed:18603530). Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites (PubMed:19959401). DNA lyase activity does not require alpha-ketboglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5' DNA product (PubMed:19959401, PubMed:23577621). DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation. May play a role in placental trophoblast lineage differentiation (By similarity). Taurus_UMD|evm.model.AC_000167.1.1009 Q32P59 SLIRP_BOVIN 100.000 0.982143 1.00901 SLIRP - SRA stem-loop-interacting RNA-binding protein, mitochondrial precursor - Bos taurus (Bovine) - SLIRP gene RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation (By similarity). Taurus_UMD|evm.model.AC_000167.1.1010 Q1JQE0 SNW1_BOVIN 100.000 0.996276 1.00187 SNW1 - SNW domain-containing protein 1 - Bos taurus (Bovine) - SNW1 gene Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Taurus_UMD|evm.model.AC_000167.1.1011 Q86TW2 ADCK1_HUMAN 86.932 0.992366 0.988679 ADCK1 - AarF domain-containing protein kinase 1 precursor - Homo sapiens (Human) - ADCK1 gene Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT (PubMed:31125351). The action of this enzyme is not yet clear (Probable). It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable). Taurus_UMD|evm.model.AC_000167.1.1012 Q9Y4C0 NRX3A_HUMAN 93.220 0.873606 0.163725 NRXN3 - Neurexin-3 precursor - Homo sapiens (Human) - NRXN3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Taurus_UMD|evm.model.AC_000167.1.1014 Q6P9K9 NRX3A_MOUSE 97.712 0.915916 0.211967 Nrxn3 - Neurexin-3 precursor - Mus musculus (Mouse) - Nrxn3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). Taurus_UMD|evm.model.AC_000167.1.1015 Q6P9K9 NRX3A_MOUSE 98.473 0.588235 0.140675 Nrxn3 - Neurexin-3 precursor - Mus musculus (Mouse) - Nrxn3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). Taurus_UMD|evm.model.AC_000167.1.1017 Q9Y4C0 NRX3A_HUMAN 94.366 0.777778 0.0547778 NRXN3 - Neurexin-3 precursor - Homo sapiens (Human) - NRXN3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Taurus_UMD|evm.model.AC_000167.1.1018 Q9Y4C0 NRX3A_HUMAN 99.695 0.755196 0.263542 NRXN3 - Neurexin-3 precursor - Homo sapiens (Human) - NRXN3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Taurus_UMD|evm.model.AC_000167.1.1020 D0PRN3 NRX3A_CHICK 87.143 0.71134 0.0572947 Neurexin-3 precursor - Gallus gallus (Chicken) Taurus_UMD|evm.model.AC_000167.1.1021 Q9Y4C0 NRX3A_HUMAN 100.000 0.54902 0.0620816 NRXN3 - Neurexin-3 precursor - Homo sapiens (Human) - NRXN3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Taurus_UMD|evm.model.AC_000167.1.1022 Q9HDB5 NRX3B_HUMAN 96.429 0.929314 0.755102 NRXN3 - Neurexin-3-beta precursor - Homo sapiens (Human) - NRXN3 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity). Taurus_UMD|evm.model.AC_000167.1.1023 Q5I3B2 IOD2_BOVIN 87.547 0.991416 0.866171 DIO2 - Type II iodothyronine deiodinase - Bos taurus (Bovine) - DIO2 gene Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. Taurus_UMD|evm.model.AC_000167.1.1024 P79103 RS4_BOVIN 95.057 0.992424 1.0038 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000167.1.1025 Q6ZU80 CE128_HUMAN 82.339 0.983683 0.784278 CEP128 - Centrosomal protein of 128 kDa - Homo sapiens (Human) - CEP128 gene centriolar subdistal appendage, centriole, spindle pole, protein localization Taurus_UMD|evm.model.AC_000167.1.1026 Q27987 TSHR_BOVIN 93.316 0.997203 0.93709 TSHR - Thyrotropin receptor precursor - Bos taurus (Bovine) - TSHR gene Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Taurus_UMD|evm.model.AC_000167.1.1027 P52655 TF2AA_HUMAN 99.202 0.994695 1.00266 GTF2A1 - Transcription initiation factor IIA subunit 1 - Homo sapiens (Human) - GTF2A1 gene TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. Taurus_UMD|evm.model.AC_000167.1.1028 Q8WXE9 STON2_HUMAN 86.613 0.971047 0.992265 STON2 - Stonin-2 - Homo sapiens (Human) - STON2 gene Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. Taurus_UMD|evm.model.AC_000167.1.1029 Q9UBV2 SE1L1_HUMAN 88.035 0.997294 0.93073 SEL1L - Protein sel-1 homolog 1 precursor - Homo sapiens (Human) - SEL1L gene Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. Taurus_UMD|evm.model.AC_000167.1.1033 Q29RK1 CISY_BOVIN 83.223 0.992424 0.849785 CS - Citrate synthase, mitochondrial precursor - Bos taurus (Bovine) - CS gene mitochondrial matrix, citrate (Si)-synthase activity, carbohydrate metabolic process, tricarboxylic acid cycle Taurus_UMD|evm.model.AC_000167.1.1035 Q95K48 POTE1_MACFA 71.287 0.891892 0.175079 POT1 - Protection of telomeres protein 1 - Macaca fascicularis (Crab-eating macaque) - POT1 gene Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity (By similarity). Taurus_UMD|evm.model.AC_000167.1.1038 O43155 FLRT2_HUMAN 94.697 0.996974 1.00152 FLRT2 - Leucine-rich repeat transmembrane protein FLRT2 precursor - Homo sapiens (Human) - FLRT2 gene Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis. Taurus_UMD|evm.model.AC_000167.1.1040 Q61553 FSCN1_MOUSE 46.154 0.407583 0.427992 Fscn1 - Fascin - Mus musculus (Mouse) - Fscn1 gene Actin-binding protein that contains 2 major actin binding sites (By similarity). Organizes filamentous actin into parallel bundles (PubMed:7738015). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (By similarity). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:21685497). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (By similarity). Taurus_UMD|evm.model.AC_000167.1.1041 Q56JZ7 ZCRB1_BOVIN 92.208 0.863636 0.40553 ZCRB1 - Zinc finger CCHC-type and RNA-binding motif-containing protein 1 - Bos taurus (Bovine) - ZCRB1 gene U12-type spliceosomal complex, mRNA splicing, via spliceosome Taurus_UMD|evm.model.AC_000167.1.1042 Q922R8 PDIA6_MOUSE 92.727 0.995465 1.00227 Pdia6 - Protein disulfide-isomerase A6 precursor - Mus musculus (Mouse) - Pdia6 gene May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:24508390). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (By similarity). May also regulate the UPR via the EIF2AK3 UPR sensor (By similarity). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (By similarity). Taurus_UMD|evm.model.AC_000167.1.1043 Q8VE62 PAIP1_MOUSE 96.907 0.821277 0.5875 Paip1 - Polyadenylate-binding protein-interacting protein 1 - Mus musculus (Mouse) - Paip1 gene Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). Taurus_UMD|evm.model.AC_000167.1.1045 P08548 LIN1_NYCCO 31.844 0.530675 0.25873 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Taurus_UMD|evm.model.AC_000167.1.1046 P11369 LORF2_MOUSE 23.636 0.941176 0.0796253 Pol - LINE-1 retrotransposable element ORF2 protein - Mus musculus (Mouse) - Pol gene Has a reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition. Has also an endonuclease activity that allows the introduction of nicks in the chromosomal target DNA. Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to sites of LINE-1 integration in the genome. Taurus_UMD|evm.model.AC_000167.1.1047 P54804 GALC_CANLF 88.341 0.966715 1.03288 GALC - Galactocerebrosidase precursor - Canis lupus familiaris (Dog) - GALC gene Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine (PubMed:8661004). Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (By similarity). Taurus_UMD|evm.model.AC_000167.1.1048 Q8IYL9 PSYR_HUMAN 78.886 0.994152 1.01484 GPR65 - Psychosine receptor - Homo sapiens (Human) - GPR65 gene Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (PubMed:11309421). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411). May have a role in activation-induced cell death or differentiation of T-cells (By similarity). Taurus_UMD|evm.model.AC_000167.1.1050 P57789 KCNKA_HUMAN 95.930 0.457219 0.695167 KCNK10 - Potassium channel subfamily K member 10 - Homo sapiens (Human) - KCNK10 gene Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids. Taurus_UMD|evm.model.AC_000167.1.1051 Q9P0W8 SPAT7_HUMAN 71.141 0.99661 0.984975 SPATA7 - Spermatogenesis-associated protein 7 - Homo sapiens (Human) - SPATA7 gene Involved in the maintenance of both rod and cone photoreceptor cells (By similarity). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as photoreceptor-specific localization of proximal CC proteins at the distal CC (By similarity). Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (By similarity). Taurus_UMD|evm.model.AC_000167.1.1052 Q16825 PTN21_HUMAN 84.309 0.998233 0.964225 PTPN21 - Tyrosine-protein phosphatase non-receptor type 21 - Homo sapiens (Human) - PTPN21 gene cytoplasm, cytoskeleton, protein tyrosine phosphatase activity, protein dephosphorylation Taurus_UMD|evm.model.AC_000167.1.1053 Q3ZC82 ZC3HE_BOVIN 99.857 0.997151 0.955102 ZC3H14 - Zinc finger CCCH domain-containing protein 14 - Bos taurus (Bovine) - ZC3H14 gene Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides. Taurus_UMD|evm.model.AC_000167.1.1054 Q05BV3 EMAL5_HUMAN 96.496 0.998985 1.00051 EML5 - Echinoderm microtubule-associated protein-like 5 - Homo sapiens (Human) - EML5 gene May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. Taurus_UMD|evm.model.AC_000167.1.1055 Q8VD72 TTC8_MOUSE 90.998 0.996016 0.974757 Ttc8 - Tetratricopeptide repeat protein 8 - Mus musculus (Mouse) - Ttc8 gene The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (By similarity). Taurus_UMD|evm.model.AC_000167.1.1059 Q33BP8 FOXN3_PIG 85.567 0.995643 0.946392 FOXN3 - Forkhead box protein N3 - Sus scrofa (Pig) - FOXN3 gene Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints) (By similarity). Taurus_UMD|evm.model.AC_000167.1.1061 Q9BUY7 EFC11_HUMAN 82.822 0.975904 1.0184 EFCAB11 - EF-hand calcium-binding domain-containing protein 11 - Homo sapiens (Human) - EFCAB11 gene calcium ion binding Taurus_UMD|evm.model.AC_000167.1.1062 Q9NUW8 TYDP1_HUMAN 82.353 0.995106 1.00822 TDP1 - Tyrosyl-DNA phosphodiesterase 1 - Homo sapiens (Human) - TDP1 gene DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. Taurus_UMD|evm.model.AC_000167.1.1063 Q9HB14 KCNKD_HUMAN 72.603 0.330275 0.534314 KCNK13 - Potassium channel subfamily K member 13 - Homo sapiens (Human) - KCNK13 gene Potassium channel displaying weak inward rectification in symmetrical K(+) solution. Taurus_UMD|evm.model.AC_000167.1.1064 P62193 PRS4_RAT 100.000 0.869307 1.14773 Psmc1 - 26S proteasome regulatory subunit 4 - Rattus norvegicus (Rat) - Psmc1 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Taurus_UMD|evm.model.AC_000167.1.1065 Q9H7Z3 NRDE2_HUMAN 79.394 0.987889 0.993127 NRDE2 - Nuclear exosome regulator NRDE2 - Homo sapiens (Human) - NRDE2 gene Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217). U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis (PubMed:30538148). Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites (PubMed:30538148). Plays a role in DNA damage response (PubMed:29902117). Taurus_UMD|evm.model.AC_000167.1.1066 P0DP31 CALM3_RAT 100.000 0.97351 1.01342 Calm3 - Calmodulin-3 - Rattus norvegicus (Rat) - Calm3 gene Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Taurus_UMD|evm.model.AC_000167.1.1068 Q86TV6 TTC7B_HUMAN 95.641 0.896089 1.06168 TTC7B - Tetratricopeptide repeat protein 7B - Homo sapiens (Human) - TTC7B gene Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (PubMed:26571211). Taurus_UMD|evm.model.AC_000167.1.1069 O75582 KS6A5_HUMAN 94.764 0.826638 1.17955 RPS6KA5 - Ribosomal protein S6 kinase alpha-5 - Homo sapiens (Human) - RPS6KA5 gene Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). Taurus_UMD|evm.model.AC_000167.1.1071 A2VE10 GOLM2_BOVIN 95.833 0.0602094 1.00526 GOLM2 - Protein GOLM2 - Bos taurus (Bovine) - GOLM2 gene Taurus_UMD|evm.model.AC_000167.1.1072 Q05D32 CTSL2_HUMAN 99.356 0.995717 1.00215 CTDSPL2 - CTD small phosphatase-like protein 2 - Homo sapiens (Human) - CTDSPL2 gene Probable phosphatase. Taurus_UMD|evm.model.AC_000167.1.1074 Q0VCU8 EIF3J_BOVIN 100.000 0.986957 0.898438 EIF3J - Eukaryotic translation initiation factor 3 subunit J - Bos taurus (Bovine) - EIF3J gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA. Taurus_UMD|evm.model.AC_000167.1.1075 Q96JI7 SPTCS_HUMAN 82.777 0.998757 0.988129 SPG11 - Spatacsin - Homo sapiens (Human) - SPG11 gene May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. Taurus_UMD|evm.model.AC_000167.1.1076 C9JE40 PATL2_HUMAN 74.453 0.868932 1.13812 PATL2 - Protein PAT1 homolog 2 - Homo sapiens (Human) - PATL2 gene RNA-binding protein that acts as a translational repressor. Taurus_UMD|evm.model.AC_000167.1.1077 P01888 B2MG_BOVIN 100.000 0.983193 1.00847 B2M - Beta-2-microglobulin precursor - Bos taurus (Bovine) - B2M gene Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Taurus_UMD|evm.model.AC_000167.1.1078 Q29RI9 MAT2B_BOVIN 98.802 0.99403 1.00299 MAT2B - Methionine adenosyltransferase 2 subunit beta - Bos taurus (Bovine) - MAT2B gene Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro). Taurus_UMD|evm.model.AC_000167.1.1079 Q86WT6 TRI69_HUMAN 85.000 0.954111 1.046 TRIM69 - E3 ubiquitin-protein ligase TRIM69 - Homo sapiens (Human) - TRIM69 gene May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis. Taurus_UMD|evm.model.AC_000168.1.3 P61129 ZC3H6_HUMAN 79.133 0.998307 0.993272 ZC3H6 - Zinc finger CCCH domain-containing protein 6 - Homo sapiens (Human) - ZC3H6 gene chromatin, nucleus Taurus_UMD|evm.model.AC_000168.1.4 Q8N5P1 ZC3H8_HUMAN 74.510 0.986971 1.05498 ZC3H8 - Zinc finger CCCH domain-containing protein 8 - Homo sapiens (Human) - ZC3H8 gene Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. Taurus_UMD|evm.model.AC_000168.1.5 Q53RD9 FBLN7_HUMAN 90.888 0.995455 1.00228 FBLN7 - Fibulin-7 precursor - Homo sapiens (Human) - FBLN7 gene An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation. Taurus_UMD|evm.model.AC_000168.1.6 Q96K49 TM87B_HUMAN 81.528 0.996441 1.01261 TMEM87B - Transmembrane protein 87B precursor - Homo sapiens (Human) - TMEM87B gene May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN). Taurus_UMD|evm.model.AC_000168.1.7 Q12866 MERTK_HUMAN 82.077 0.98 1.001 MERTK - Tyrosine-protein kinase Mer precursor - Homo sapiens (Human) - MERTK gene Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Taurus_UMD|evm.model.AC_000168.1.8 Q9H1A4 APC1_HUMAN 95.525 0.998971 1 ANAPC1 - Anaphase-promoting complex subunit 1 - Homo sapiens (Human) - ANAPC1 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Taurus_UMD|evm.model.AC_000168.1.9 A6NJR5 SPDL3_HUMAN 54.088 0.6 0.896552 Putative speedy protein-like protein 3 - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000168.1.10 A1A4Q3 HBM_BOVIN 87.805 0.632812 0.907801 HBM - Hemoglobin subunit mu - Bos taurus (Bovine) - HBM gene haptoglobin-hemoglobin complex, hemoglobin complex, heme binding, organic acid binding, oxygen binding, oxygen carrier activity, hydrogen peroxide catabolic process Taurus_UMD|evm.model.AC_000168.1.12 Q17QD9 CSEN_BOVIN 92.683 0.515284 0.894531 KCNIP3 - Calsenilin - Bos taurus (Bovine) - KCNIP3 gene Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Taurus_UMD|evm.model.AC_000168.1.14 O43521 B2L11_HUMAN 87.500 0.299845 3.26768 BCL2L11 - Bcl-2-like protein 11 - Homo sapiens (Human) - BCL2L11 gene Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. Taurus_UMD|evm.model.AC_000168.1.15 Q9NUZ1 ACOXL_HUMAN 83.857 0.41573 0.976234 ACOXL - Acyl-coenzyme A oxidase-like protein - Homo sapiens (Human) - ACOXL gene peroxisomal matrix, peroxisome, acyl-CoA oxidase activity, fatty acid binding, flavin adenine dinucleotide binding, fatty acid beta-oxidation using acyl-CoA oxidase, lipid homeostasis Taurus_UMD|evm.model.AC_000168.1.16 Q9NUZ1 ACOXL_HUMAN 88.095 0.828383 0.553931 ACOXL - Acyl-coenzyme A oxidase-like protein - Homo sapiens (Human) - ACOXL gene peroxisomal matrix, peroxisome, acyl-CoA oxidase activity, fatty acid binding, flavin adenine dinucleotide binding, fatty acid beta-oxidation using acyl-CoA oxidase, lipid homeostasis Taurus_UMD|evm.model.AC_000168.1.17 O43683 BUB1_HUMAN 78.913 0.998152 0.997235 BUB1 - Mitotic checkpoint serine/threonine-protein kinase BUB1 - Homo sapiens (Human) - BUB1 gene Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. Taurus_UMD|evm.model.AC_000168.1.18 Q9ULQ1 TPC1_HUMAN 29.391 0.681643 0.954657 TPCN1 - Two pore calcium channel protein 1 - Homo sapiens (Human) - TPCN1 gene Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. Taurus_UMD|evm.model.AC_000168.1.19 Q8NCU8 MTLN_HUMAN 96.429 0.964912 1.01786 MTLN - Mitoregulin - Homo sapiens (Human) - MTLN gene Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential while decreasing mitochondrial reactive oxygen species (PubMed:29949756). Increases mitochondrial respiration rate (PubMed:29949756). Increased mitochondrial respiratory activity promotes myogenic differentiation which facilitates muscle growth and regeneration (By similarity). Increases mitochondrial calcium retention capacity (PubMed:29949756). Plays a role in maintenance of cellular lipid composition through its interaction with cytochrome b5 reductase CYB5R3 which is required for mitochondrial respiratory complex I activity (By similarity). Interacts with the mitochondrial trifunctional enzyme complex (MTE) and enhances fatty acid beta-oxidation (PubMed:32243843). Not required for MTE formation or stability (By similarity). Modulates triglyceride clearance in adipocytes through its role in regulating fatty acid beta-oxidation and lipolysis (PubMed:32243843). Taurus_UMD|evm.model.AC_000168.1.20 Q9TU19 NPHP1_CANLF 86.891 0.612198 1.53805 NPHP1 - Nephrocystin-1 - Canis lupus familiaris (Dog) - NPHP1 gene Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly (By similarity). Required for normal retina development (By similarity). In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity). Taurus_UMD|evm.model.AC_000168.1.21 Q3ZBY0 MAL_BOVIN 99.346 0.987013 1.00654 MAL - Myelin and lymphocyte protein - Bos taurus (Bovine) - MAL gene Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function (By similarity). Taurus_UMD|evm.model.AC_000168.1.22 Q28296 MAL_CANLF 69.281 0.94375 1.04575 MAL - Myelin and lymphocyte protein - Canis lupus familiaris (Dog) - MAL gene Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function. Taurus_UMD|evm.model.AC_000168.1.23 Q2KID9 RT05_BOVIN 100.000 0.99536 1.00233 MRPS5 - 28S ribosomal protein S5, mitochondrial - Bos taurus (Bovine) - MRPS5 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation, translation Taurus_UMD|evm.model.AC_000168.1.24 Q96K75 ZN514_HUMAN 80.000 0.44898 0.245 ZNF514 - Zinc finger protein 514 - Homo sapiens (Human) - ZNF514 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000168.1.25 Q6ECI4 ZN470_HUMAN 59.587 0.417817 1.11158 ZNF470 - Zinc finger protein 470 - Homo sapiens (Human) - ZNF470 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000168.1.26 Q8N271 PROM2_HUMAN 78.298 0.970024 1 PROM2 - Prominin-2 precursor - Homo sapiens (Human) - PROM2 gene apical plasma membrane, cell projection, cell surface, cilium, cytoplasmic vesicle, extracellular exosome, integral component of plasma membrane, microspike, microvillus, prominosome Taurus_UMD|evm.model.AC_000168.1.27 Q17QD9 CSEN_BOVIN 96.154 0.707763 0.855469 KCNIP3 - Calsenilin - Bos taurus (Bovine) - KCNIP3 gene Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Taurus_UMD|evm.model.AC_000168.1.28 Q2KIB0 FAHD2_BOVIN 99.363 0.993651 1.00318 FAHD2 - Fumarylacetoacetate hydrolase domain-containing protein 2 - Bos taurus (Bovine) - FAHD2 gene May have hydrolase activity. Taurus_UMD|evm.model.AC_000168.1.29 Q6NUI2 GPAT2_HUMAN 85.019 0.997503 1.00755 GPAT2 - Glycerol-3-phosphate acyltransferase 2, mitochondrial - Homo sapiens (Human) - GPAT2 gene Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids. In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA). Prefers arachidonoyl-CoA as the acyl donor. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity. Taurus_UMD|evm.model.AC_000168.1.30 O77700 ADA2B_BOVIN 100.000 0.872768 1.14286 ADRA2B - Alpha-2B adrenergic receptor - Bos taurus (Bovine) - ADRA2B gene Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Taurus_UMD|evm.model.AC_000168.1.32 Q6HA08 ASTL_HUMAN 75.000 0.931579 0.881671 ASTL - Astacin-like metalloendopeptidase precursor - Homo sapiens (Human) - ASTL gene Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity). Taurus_UMD|evm.model.AC_000168.1.33 Q05923 DUS2_HUMAN 90.127 0.993651 1.00318 DUSP2 - Dual specificity protein phosphatase 2 - Homo sapiens (Human) - DUSP2 gene Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. Taurus_UMD|evm.model.AC_000168.1.34 Q9NQZ5 STAR7_HUMAN 88.204 0.994429 0.97027 STARD7 - StAR-related lipid transfer protein 7, mitochondrial precursor - Homo sapiens (Human) - STARD7 gene May play a protective role in mucosal tissues by preventing exaggerated allergic responses. Taurus_UMD|evm.model.AC_000168.1.35 O75204 TM127_HUMAN 99.580 0.991632 1.0042 TMEM127 - Transmembrane protein 127 - Homo sapiens (Human) - TMEM127 gene Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor. Taurus_UMD|evm.model.AC_000168.1.36 Q32PJ6 CIAO1_BOVIN 100.000 0.994118 1.00295 CIAO1 - Probable cytosolic iron-sulfur protein assembly protein CIAO1 - Bos taurus (Bovine) - CIAO1 gene Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (By similarity). Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity). Taurus_UMD|evm.model.AC_000168.1.37 O75643 U520_HUMAN 99.298 0.999064 1.00047 SNRNP200 - U5 small nuclear ribonucleoprotein 200 kDa helicase - Homo sapiens (Human) - SNRNP200 gene Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Taurus_UMD|evm.model.AC_000168.1.38 P84246 H33_RABIT 95.588 0.985401 1.00735 H3-3A - Histone H3.3 - Oryctolagus cuniculus (Rabbit) - H3-3A gene Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000168.1.39 Q6GPH6 IPIL1_HUMAN 90.659 0.994526 0.987387 ITPRIPL1 - Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 precursor - Homo sapiens (Human) - ITPRIPL1 gene membrane Taurus_UMD|evm.model.AC_000168.1.40 Q15003 CND2_HUMAN 80.108 0.994543 0.989204 NCAPH - Condensin complex subunit 2 - Homo sapiens (Human) - NCAPH gene Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). Taurus_UMD|evm.model.AC_000168.1.41 Q96EH8 NEUL3_HUMAN 71.264 0.955556 1.03053 NEURL3 - E3 ubiquitin-protein ligase NEURL3 - Homo sapiens (Human) - NEURL3 gene E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation. Taurus_UMD|evm.model.AC_000168.1.42 Q3SWY1 ARI5A_BOVIN 100.000 0.996627 1.00169 ARID5A - AT-rich interactive domain-containing protein 5A - Bos taurus (Bovine) - ARID5A gene DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes. May act as repressor and down-regulate enhancer-dependent gene expressison. May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention. Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors. As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock. Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity). Taurus_UMD|evm.model.AC_000168.1.43 Q9P2N6 KANL3_HUMAN 94.027 0.99779 1.00111 KANSL3 - KAT8 regulatory NSL complex subunit 3 - Homo sapiens (Human) - KANSL3 gene As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. Taurus_UMD|evm.model.AC_000168.1.44 A0AVI2 FR1L5_HUMAN 78.080 0.999028 1.00049 FER1L5 - Fer-1-like protein 5 - Homo sapiens (Human) - FER1L5 gene Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation. Taurus_UMD|evm.model.AC_000168.1.45 Q2HJD1 LMA2L_BOVIN 96.936 0.994444 1.03448 LMAN2L - VIP36-like protein precursor - Bos taurus (Bovine) - LMAN2L gene May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53 (By similarity). Taurus_UMD|evm.model.AC_000168.1.46 Q6P4Q7 CNNM4_HUMAN 81.720 0.996689 0.779355 CNNM4 - Metal transporter CNNM4 - Homo sapiens (Human) - CNNM4 gene Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. Taurus_UMD|evm.model.AC_000168.1.47 Q8NE01 CNNM3_HUMAN 85.255 0.989348 1.06223 CNNM3 - Metal transporter CNNM3 - Homo sapiens (Human) - CNNM3 gene Probable metal transporter. Taurus_UMD|evm.model.AC_000168.1.49 Q86SG2 ANR23_HUMAN 80.719 0.993464 1.00328 ANKRD23 - Ankyrin repeat domain-containing protein 23 - Homo sapiens (Human) - ANKRD23 gene May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression. Taurus_UMD|evm.model.AC_000168.1.50 Q0P5B9 ANR39_BOVIN 100.000 0.98913 1.00546 ANKRD39 - Ankyrin repeat domain-containing protein 39 - Bos taurus (Bovine) - ANKRD39 gene cytoplasm, nucleus, NAD+ ADP-ribosyltransferase activity, positive regulation of canonical Wnt signaling pathway, positive regulation of telomere capping, protein ADP-ribosylation, protein localization to chromosome, telomeric region Taurus_UMD|evm.model.AC_000168.1.51 Q9C0C4 SEM4C_HUMAN 93.277 0.997602 1.0012 SEMA4C - Semaphorin-4C precursor - Homo sapiens (Human) - SEMA4C gene Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. Taurus_UMD|evm.model.AC_000168.1.52 Q8IXR5 F178B_HUMAN 63.359 0.99688 0.944035 FAM178B - Protein FAM178B - Homo sapiens (Human) - FAM178B gene Taurus_UMD|evm.model.AC_000168.1.53 P00428 COX5B_BOVIN 100.000 0.984615 1.00775 COX5B - Cytochrome c oxidase subunit 5B, mitochondrial precursor - Bos taurus (Bovine) - COX5B gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000168.1.54 A4IFE3 ACTY_BOVIN 86.772 0.994709 1.00532 ACTR1B - Beta-centractin - Bos taurus (Bovine) - ACTR1B gene Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity). Taurus_UMD|evm.model.AC_000168.1.55 A0A1B0GVN3 CB092_HUMAN 49.242 0.821656 1.18491 C2orf92 - Uncharacterized protein C2orf92 precursor - Homo sapiens (Human) - C2orf92 gene Taurus_UMD|evm.model.AC_000168.1.56 P43404 ZAP70_MOUSE 93.355 0.995146 1 Zap70 - Tyrosine-protein kinase ZAP-70 - Mus musculus (Mouse) - Zap70 gene Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). Taurus_UMD|evm.model.AC_000168.1.57 Q92545 TM131_HUMAN 91.662 0.998934 0.996814 TMEM131 - Transmembrane protein 131 - Homo sapiens (Human) - TMEM131 gene May play a role in the immune response to viral infection. Taurus_UMD|evm.model.AC_000168.1.58 Q502W6 VWA3B_HUMAN 77.494 0.968701 0.987635 VWA3B - von Willebrand factor A domain-containing protein 3B - Homo sapiens (Human) - VWA3B gene cytosol, nucleoplasm Taurus_UMD|evm.model.AC_000168.1.59 Q29441 CNGA3_BOVIN 100.000 0.997171 1.00142 CNGA3 - Cyclic nucleotide-gated cation channel alpha-3 - Bos taurus (Bovine) - CNGA3 gene Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Could be responsible for cGMP-induced calcium entry in cells other than sensory cells. Might be involved in chemotaxis of sperm. Taurus_UMD|evm.model.AC_000168.1.62 Q96PE3 INP4A_HUMAN 94.688 0.99794 0.993859 INPP4A - Inositol polyphosphate-4-phosphatase type I A - Homo sapiens (Human) - INPP4A gene Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:20463662, PubMed:15716355). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:30071275) (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity). Taurus_UMD|evm.model.AC_000168.1.63 Q3ZBG6 UNC50_BOVIN 100.000 0.992308 1.00386 UNC50 - Protein unc-50 homolog - Bos taurus (Bovine) - UNC50 gene May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity). Taurus_UMD|evm.model.AC_000168.1.64 O77836 MGT4A_BOVIN 96.634 0.994036 0.940187 MGAT4A - Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A - Bos taurus (Bovine) - MGAT4A gene Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells. Taurus_UMD|evm.model.AC_000168.1.65 Q6NV74 CRCDL_HUMAN 63.000 0.997824 0.955301 CRACDL - CRACD-like protein - Homo sapiens (Human) - CRACDL gene Taurus_UMD|evm.model.AC_000168.1.66 Q6NY15 TSG10_MOUSE 96.848 0.754881 1.32281 Tsga10 - Testis-specific gene 10 protein - Mus musculus (Mouse) - Tsga10 gene Plays a role in spermatogenesis (PubMed:14585816). When overexpressed, prevents nuclear localization of HIF1A (PubMed:16777103). Taurus_UMD|evm.model.AC_000168.1.67 O46419 LIPT_BOVIN 100.000 0.994652 1.00268 LIPT1 - Lipoyltransferase 1, mitochondrial precursor - Bos taurus (Bovine) - LIPT1 gene Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes. Taurus_UMD|evm.model.AC_000168.1.68 Q8WV92 MITD1_HUMAN 83.936 0.991968 1 MITD1 - MIT domain-containing protein 1 - Homo sapiens (Human) - MITD1 gene Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex. Taurus_UMD|evm.model.AC_000168.1.69 Q58DV5 RM30_BOVIN 99.379 0.987654 1.00621 MRPL30 - 39S ribosomal protein L30, mitochondrial precursor - Bos taurus (Bovine) - MRPL30 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Taurus_UMD|evm.model.AC_000168.1.70 Q86SG7 LYG2_HUMAN 72.642 0.596045 1.66981 LYG2 - Lysozyme g-like protein 2 precursor - Homo sapiens (Human) - LYG2 gene May act as a potent antibacterial protein that may play a role in the innate immunity. Taurus_UMD|evm.model.AC_000168.1.71 O18883 TXND9_BOVIN 99.558 0.991189 1.00442 TXNDC9 - Thioredoxin domain-containing protein 9 - Bos taurus (Bovine) - TXNDC9 gene Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin. Taurus_UMD|evm.model.AC_000168.1.72 O60841 IF2P_HUMAN 92.376 0.998378 1.01066 EIF5B - Eukaryotic translation initiation factor 5B - Homo sapiens (Human) - EIF5B gene Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. Taurus_UMD|evm.model.AC_000168.1.73 Q9UBZ9 REV1_HUMAN 82.330 0.680071 0.894484 REV1 - DNA repair protein REV1 - Homo sapiens (Human) - REV1 gene Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Taurus_UMD|evm.model.AC_000168.1.74 P51826 AFF3_HUMAN 87.030 0.998395 1.01631 AFF3 - AF4/FMR2 family member 3 - Homo sapiens (Human) - AFF3 gene Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA. Taurus_UMD|evm.model.AC_000168.1.77 Q5RBZ6 CHSTA_PONAB 89.744 0.40684 2.38202 CHST10 - Carbohydrate sulfotransferase 10 - Pongo abelii (Sumatran orangutan) - CHST10 gene Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis (By similarity). Taurus_UMD|evm.model.AC_000168.1.78 Q0VCW8 PDCL3_BOVIN 99.167 0.991701 1.00417 PDCL3 - Phosducin-like protein 3 - Bos taurus (Bovine) - PDCL3 gene Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (By similarity). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity). Taurus_UMD|evm.model.AC_000168.1.79 Q12923 PTN13_HUMAN 88.403 0.995633 0.184306 PTPN13 - Tyrosine-protein phosphatase non-receptor type 13 - Homo sapiens (Human) - PTPN13 gene Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). Taurus_UMD|evm.model.AC_000168.1.80 A6QP84 SOAT_BOVIN 100.000 0.991803 0.647215 SLC10A6 - Solute carrier family 10 member 6 - Bos taurus (Bovine) - SLC10A6 gene Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner. Taurus_UMD|evm.model.AC_000168.1.81 Q99743 NPAS2_HUMAN 83.374 0.905325 1.02549 NPAS2 - Neuronal PAS domain-containing protein 2 - Homo sapiens (Human) - NPAS2 gene Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. NPAS2 plays an important role in sleep homeostasis and in maintaining circadian behaviors in normal light/dark and feeding conditions and in the effective synchronization of feeding behavior with scheduled food availability. Regulates the gene transcription of key metabolic pathways in the liver and is involved in DNA damage response by regulating several cell cycle and DNA repair genes. Controls the circadian rhythm of NR0B2 expression by binding rhythmically to its promoter (By similarity). Mediates the diurnal variation in the expression of GABARA1 receptor in the brain and contributes to the regulation of anxiety-like behaviors and GABAergic neurotransmission in the ventral striatum (By similarity). Taurus_UMD|evm.model.AC_000168.1.82 P62902 RL31_RAT 100.000 0.984127 1.008 Rpl31 - 60S ribosomal protein L31 - Rattus norvegicus (Rat) - Rpl31 gene cytosolic large ribosomal subunit, nucleolus, nucleoplasm, polysomal ribosome, synapse, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000168.1.83 O95759 TBCD8_HUMAN 91.354 0.997375 1.00263 TBC1D8 - TBC1 domain family member 8 - Homo sapiens (Human) - TBC1D8 gene May act as a GTPase-activating protein for Rab family protein(s). Taurus_UMD|evm.model.AC_000168.1.84 Q9UKZ1 CNO11_HUMAN 99.333 0.995565 0.884314 CNOT11 - CCR4-NOT transcription complex subunit 11 - Homo sapiens (Human) - CNOT11 gene Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function. Taurus_UMD|evm.model.AC_000168.1.85 Q8NC42 RN149_HUMAN 79.397 0.989848 0.985 RNF149 - E3 ubiquitin-protein ligase RNF149 precursor - Homo sapiens (Human) - RNF149 gene E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation. Taurus_UMD|evm.model.AC_000168.1.86 Q8IUH2 CREG2_HUMAN 81.884 0.953571 0.965517 CREG2 - Protein CREG2 precursor - Homo sapiens (Human) - CREG2 gene extracellular space Taurus_UMD|evm.model.AC_000168.1.87 Q6ZV50 RFX8_HUMAN 74.579 0.986689 1.0256 RFX8 - DNA-binding protein RFX8 - Homo sapiens (Human) - RFX8 gene May be a transcription factor. Taurus_UMD|evm.model.AC_000168.1.88 O95819 M4K4_HUMAN 96.394 0.341845 0.979822 MAP4K4 - Mitogen-activated protein kinase kinase kinase kinase 4 - Homo sapiens (Human) - MAP4K4 gene Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. Taurus_UMD|evm.model.AC_000168.1.89 P27930 IL1R2_HUMAN 70.529 0.977556 1.00754 IL1R2 - Interleukin-1 receptor type 2 precursor - Homo sapiens (Human) - IL1R2 gene Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Taurus_UMD|evm.model.AC_000168.1.90 Q7TQK0 CCNT2_MOUSE 55.072 0.435897 0.215768 Ccnt2 - Cyclin-T2 - Mus musculus (Mouse) - Ccnt2 gene Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). The activity of this complex is regulated by binding with 7SK snRNA (By similarity). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (PubMed:16245309, PubMed:23060074, PubMed:12037670). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (By similarity). Involved in early embryo development (PubMed:19364821). Taurus_UMD|evm.model.AC_000168.1.91 P14778 IL1R1_HUMAN 72.251 0.996516 1.00879 IL1R1 - Interleukin-1 receptor type 1 precursor - Homo sapiens (Human) - IL1R1 gene Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850). Taurus_UMD|evm.model.AC_000168.1.92 Q9HB29 ILRL2_HUMAN 68.036 0.957118 1.01391 IL1RL2 - Interleukin-1 receptor-like 2 precursor - Homo sapiens (Human) - IL1RL2 gene Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. Taurus_UMD|evm.model.AC_000168.1.93 Q6AI14 SL9A4_HUMAN 85.586 0.104049 2.66165 SLC9A4 - Sodium/hydrogen exchanger 4 - Homo sapiens (Human) - SLC9A4 gene Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity). Taurus_UMD|evm.model.AC_000168.1.94 P50482 SL9A2_RABIT 96.178 0.428181 0.903585 SLC9A2 - Sodium/hydrogen exchanger 2 - Oryctolagus cuniculus (Rabbit) - SLC9A2 gene Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption. Taurus_UMD|evm.model.AC_000168.1.95 Q8NBP5 MFSD9_HUMAN 67.949 0.960905 1.02532 MFSD9 - Major facilitator superfamily domain-containing protein 9 - Homo sapiens (Human) - MFSD9 gene Taurus_UMD|evm.model.AC_000168.1.96 A4IF75 TM182_BOVIN 100.000 0.470199 0.659389 TMEM182 - Transmembrane protein 182 precursor - Bos taurus (Bovine) - TMEM182 gene Taurus_UMD|evm.model.AC_000168.1.97 O43572 AKA10_HUMAN 94.928 0.652381 0.317221 AKAP10 - A-kinase anchor protein 10, mitochondrial precursor - Homo sapiens (Human) - AKAP10 gene Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). Taurus_UMD|evm.model.AC_000168.1.100 P20264 PO3F3_HUMAN 97.685 0.918455 0.466 POU3F3 - POU domain, class 3, transcription factor 3 - Homo sapiens (Human) - POU3F3 gene Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development (PubMed:31303265). Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity). Taurus_UMD|evm.model.AC_000168.1.103 Q58DQ5 RT09_BOVIN 100.000 0.994962 1.00253 MRPS9 - 28S ribosomal protein S9, mitochondrial precursor - Bos taurus (Bovine) - MRPS9 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit, RNA binding, structural constituent of ribosome Taurus_UMD|evm.model.AC_000168.1.104 Q9Y5Y3 GPR45_HUMAN 81.501 0.994652 1.00538 GPR45 - Probable G-protein coupled receptor 45 - Homo sapiens (Human) - GPR45 gene Orphan receptor. May play a role in brain function. Taurus_UMD|evm.model.AC_000168.1.105 A7MB11 TGFA1_BOVIN 99.651 0.986207 1.01281 TGFBRAP1 - Transforming growth factor-beta receptor-associated protein 1 - Bos taurus (Bovine) - TGFBRAP1 gene Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 (By similarity). Taurus_UMD|evm.model.AC_000168.1.106 A2VDP0 ASHWN_BOVIN 100.000 0.991416 1.00431 Ashwin - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000168.1.107 Q2KI95 FHL2_BOVIN 100.000 0.992857 1.00358 FHL2 - Four and a half LIM domains protein 2 - Bos taurus (Bovine) - FHL2 gene May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (By similarity). Taurus_UMD|evm.model.AC_000168.1.108 P30547 NK1R_CAVPO 99.231 0.781818 0.405405 TACR1 - Substance-P receptor - Cavia porcellus (Guinea pig) - TACR1 gene This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. Taurus_UMD|evm.model.AC_000168.1.109 Q5DUB3 NK1R_CANLF 93.885 0.923333 0.737101 TACR1 - Substance-P receptor - Canis lupus familiaris (Dog) - TACR1 gene This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Taurus_UMD|evm.model.AC_000168.1.110 A6QQ14 DPOE4_BOVIN 98.261 0.735484 1.33621 POLE4 - DNA polymerase epsilon subunit 4 - Bos taurus (Bovine) - POLE4 gene Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Taurus_UMD|evm.model.AC_000168.1.111 Q1W674 HXK2_PIG 97.710 0.997821 1.00109 HK2 - Hexokinase-2 - Sus scrofa (Pig) - HK2 gene Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. Taurus_UMD|evm.model.AC_000168.1.112 Q9Z123 SEM4F_MOUSE 90.135 0.955959 0.993565 Sema4f - Semaphorin-4F precursor - Mus musculus (Mouse) - Sema4f gene Probable cell surface receptor that regulates oligodendroglial precursor cell migration (PubMed:21945643). Might also regulate differentiation of oligodendroglial precursor cells (By similarity). Has growth cone collapse activity against retinal ganglion-cell axons (By similarity). Taurus_UMD|evm.model.AC_000168.1.113 Q8TC57 M1AP_HUMAN 86.538 0.161392 0.596226 M1AP - Meiosis 1 arrest protein - Homo sapiens (Human) - M1AP gene Required for meiosis I progression during spermatogenesis. Taurus_UMD|evm.model.AC_000168.1.114 Q5EA84 DOK1_BOVIN 99.793 0.995868 1.00207 DOK1 - Docking protein 1 - Bos taurus (Bovine) - DOK1 gene DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). Taurus_UMD|evm.model.AC_000168.1.115 P58215 LOXL3_HUMAN 95.219 0.914738 1.09031 LOXL3 - Lysyl oxidase homolog 3 precursor - Homo sapiens (Human) - LOXL3 gene Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:17018530, PubMed:28065600). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:17018530). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600). Also able to catalyze deacetylation of lysine residues on STAT3 (PubMed:28065600). Taurus_UMD|evm.model.AC_000168.1.116 A0JNK3 HTRA2_BOVIN 100.000 0.995643 1.00218 HTRA2 - Serine protease HTRA2, mitochondrial precursor - Bos taurus (Bovine) - HTRA2 gene Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis (By similarity). Taurus_UMD|evm.model.AC_000168.1.117 Q9Y679 AUP1_HUMAN 94.878 0.995134 1.00244 AUP1 - Lipid droplet-regulating VLDL assembly factor AUP1 - Homo sapiens (Human) - AUP1 gene Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (PubMed:18711132, PubMed:21857022). Plays a role in lipid droplet formation (PubMed:21857022). Induces lipid droplet clustering (PubMed:24039768). Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation (PubMed:23223569, PubMed:21127063). Also required for the degradation of INSIG1, SREBF1 and SREBF2 (PubMed:23223569). Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB (PubMed:28183703). Taurus_UMD|evm.model.AC_000168.1.118 Q3ZBE0 DQX1_BOVIN 100.000 0.997222 1.00139 DQX1 - ATP-dependent RNA helicase DQX1 - Bos taurus (Bovine) - DQX1 gene spliceosomal complex, RNA binding Taurus_UMD|evm.model.AC_000168.1.119 O43763 TLX2_HUMAN 94.366 0.992982 1.00352 TLX2 - T-cell leukemia homeobox protein 2 - Homo sapiens (Human) - TLX2 gene Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity). Taurus_UMD|evm.model.AC_000168.1.120 Q2YDF9 PCGF1_BOVIN 99.614 0.992308 1.00386 PCGF1 - Polycomb group RING finger protein 1 - Bos taurus (Bovine) - PCGF1 gene Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells. Taurus_UMD|evm.model.AC_000168.1.121 Q6XYB7 LBX2_HUMAN 79.293 0.989848 0.994949 LBX2 - Transcription factor LBX2 - Homo sapiens (Human) - LBX2 gene Transcription factor. Taurus_UMD|evm.model.AC_000168.1.122 Q17RM4 CC142_HUMAN 75.065 0.997372 1.01467 CCDC142 - Coiled-coil domain-containing protein 142 - Homo sapiens (Human) - CCDC142 gene Taurus_UMD|evm.model.AC_000168.1.123 Q2HJF1 RM53_BOVIN 100.000 0.982301 1.00893 MRPL53 - 39S ribosomal protein L53, mitochondrial precursor - Bos taurus (Bovine) - MRPL53 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Taurus_UMD|evm.model.AC_000168.1.124 Q13724 MOGS_HUMAN 89.861 0.997226 0.86141 MOGS - Mannosyl-oligosaccharide glucosidase - Homo sapiens (Human) - MOGS gene Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner. Taurus_UMD|evm.model.AC_000168.1.125 Q96G27 WBP1_HUMAN 85.874 0.992593 1.00372 WBP1 - WW domain-binding protein 1 - Homo sapiens (Human) - WBP1 gene WW domain binding Taurus_UMD|evm.model.AC_000168.1.126 Q9C086 IN80B_HUMAN 95.787 0.949198 1.05056 INO80B - INO80 complex subunit B - Homo sapiens (Human) - INO80B gene Induces growth and cell cycle arrests at the G1 phase of the cell cycle. Taurus_UMD|evm.model.AC_000168.1.127 Q9BST9 RTKN_HUMAN 90.603 0.99646 1.00355 RTKN - Rhotekin - Homo sapiens (Human) - RTKN gene Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. Taurus_UMD|evm.model.AC_000168.1.128 Q9H977 WDR54_HUMAN 88.922 0.99403 1.00299 WDR54 - WD repeat-containing protein 54 - Homo sapiens (Human) - WDR54 gene When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation. Taurus_UMD|evm.model.AC_000168.1.129 A8NIX5 CB081_BOVIN 100.000 0.247117 1.20676 Uncharacterized protein C2orf81 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000168.1.130 P59837 RDH12_BOVIN 42.756 0.845921 1.04747 RDH12 - Retinol dehydrogenase 12 - Bos taurus (Bovine) - RDH12 gene Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards steroids. Taurus_UMD|evm.model.AC_000168.1.131 O08788 DCTN1_MOUSE 94.650 0.945619 1.03357 Dctn1 - Dynactin subunit 1 - Mus musculus (Mouse) - Dctn1 gene Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon. Plays a role in metaphase spindle orientation. Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole. Plays a role in primary cilia formation. Taurus_UMD|evm.model.AC_000168.1.132 Q07817 B2CL1_HUMAN 86.400 0.712644 0.746781 BCL2L1 - Bcl-2-like protein 1 - Homo sapiens (Human) - BCL2L1 gene Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Taurus_UMD|evm.model.AC_000168.1.133 Q6RI88 S4A5_RAT 90.651 0.806883 0.940647 Slc4a5 - Electrogenic sodium bicarbonate cotransporter 4 - Rattus norvegicus (Rat) - Slc4a5 gene Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH. Taurus_UMD|evm.model.AC_000168.1.134 Q0P5C2 MTDC_BOVIN 100.000 0.994302 1.00286 MTHFD2 - Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor - Bos taurus (Bovine) - MTHFD2 gene Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. Taurus_UMD|evm.model.AC_000168.1.135 Q3T1J9 MOB1A_RAT 100.000 0.990783 1.00463 Mob1a - MOB kinase activator 1A - Rattus norvegicus (Rat) - Mob1a gene Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity). Taurus_UMD|evm.model.AC_000168.1.136 Q3SZ84 BOLA3_BOVIN 100.000 0.981982 1.00909 BOLA3 - BolA-like protein 3 - Bos taurus (Bovine) - BOLA3 gene Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1. Taurus_UMD|evm.model.AC_000168.1.137 O43151 TET3_HUMAN 91.035 0.998794 0.923677 TET3 - Methylcytosine dioxygenase TET3 - Homo sapiens (Human) - TET3 gene Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization (PubMed:31928709). Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation (By similarity). Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes (PubMed:23217707). In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT (PubMed:23353889). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). Taurus_UMD|evm.model.AC_000168.1.138 Q16854 DGUOK_HUMAN 84.116 0.992806 1.00361 DGUOK - Deoxyguanosine kinase, mitochondrial precursor - Homo sapiens (Human) - DGUOK gene Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:8692979, PubMed:8706825, PubMed:11687801, PubMed:17073823, PubMed:23043144). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents. Taurus_UMD|evm.model.AC_000168.1.139 P63269 ACTH_RAT 94.681 0.994398 0.949468 Actg2 - Actin, gamma-enteric smooth muscle precursor - Rattus norvegicus (Rat) - Actg2 gene Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Taurus_UMD|evm.model.AC_000168.1.140 O95630 STABP_HUMAN 91.981 0.946188 1.05189 STAMBP - STAM-binding protein - Homo sapiens (Human) - STAMBP gene Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. Taurus_UMD|evm.model.AC_000168.1.141 A6NCI8 CB078_HUMAN 75.000 0.317742 0.672451 C2orf78 - Uncharacterized protein C2orf78 - Homo sapiens (Human) - C2orf78 gene Taurus_UMD|evm.model.AC_000168.1.142 Q5E999 DUS11_BOVIN 99.698 0.993976 1.00302 DUSP11 - RNA/RNP complex-1-interacting phosphatase - Bos taurus (Bovine) - DUSP11 gene Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism. Taurus_UMD|evm.model.AC_000168.1.143 Q9Y3C4 TPRKB_HUMAN 90.857 0.988636 1.00571 TPRKB - EKC/KEOPS complex subunit TPRKB - Homo sapiens (Human) - TPRKB gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:28805828). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:28805828). TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828). Taurus_UMD|evm.model.AC_000168.1.144 Q8TCU4 ALMS1_HUMAN 67.954 0.0674127 0.879079 ALMS1 - Alstrom syndrome protein 1 - Homo sapiens (Human) - ALMS1 gene Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells. Taurus_UMD|evm.model.AC_000168.1.145 Q9GL32 EGR4_BOVIN 99.793 0.995859 1.00207 EGR4 - Early growth response protein 4 - Bos taurus (Bovine) - EGR4 gene Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity). Taurus_UMD|evm.model.AC_000168.1.146 Q8TF61 FBX41_HUMAN 96.449 0.996528 0.987429 FBXO41 - F-box only protein 41 - Homo sapiens (Human) - FBXO41 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000168.1.147 Q2NKZ1 TCPH_BOVIN 100.000 0.996324 1.00184 CCT7 - T-complex protein 1 subunit eta - Bos taurus (Bovine) - CCT7 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin. Taurus_UMD|evm.model.AC_000168.1.148 Q9BSG0 PADC1_HUMAN 98.936 0.989418 1.00532 PRADC1 - Protease-associated domain-containing protein 1 precursor - Homo sapiens (Human) - PRADC1 gene Plays a role in the modulation of physical activity and adiposity. Taurus_UMD|evm.model.AC_000168.1.149 Q6GMV2 SMYD5_HUMAN 96.411 0.995227 1.00239 SMYD5 - SET and MYND domain-containing protein 5 - Homo sapiens (Human) - SMYD5 gene Taurus_UMD|evm.model.AC_000168.1.150 Q06615 NOTO_XENLA 65.517 0.215909 1.11864 noto - Homeobox protein notochord - Xenopus laevis (African clawed frog) - noto gene Transcriptional repressor. Plays a fundamental role in notochord formation, acting within the mesodermal region. Taurus_UMD|evm.model.AC_000168.1.151 P24666 PPAC_HUMAN 86.624 0.981132 1.00633 ACP1 - Low molecular weight phosphotyrosine protein phosphatase - Homo sapiens (Human) - ACP1 gene Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity. Taurus_UMD|evm.model.AC_000168.1.152 Q9BXF6 RFIP5_HUMAN 90.057 0.396055 2.01838 RAB11FIP5 - Rab11 family-interacting protein 5 - Homo sapiens (Human) - RAB11FIP5 gene Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. Taurus_UMD|evm.model.AC_000168.1.153 Q8TD22 SFXN5_HUMAN 98.235 0.994135 1.00294 SFXN5 - Sideroflexin-5 - Homo sapiens (Human) - SFXN5 gene Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (PubMed:30442778). Transports citrate (By similarity). Taurus_UMD|evm.model.AC_000168.1.154 Q04741 EMX1_HUMAN 98.054 0.878893 1.12451 EMX1 - Homeobox protein EMX1 - Homo sapiens (Human) - EMX1 gene Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system. Taurus_UMD|evm.model.AC_000168.1.155 Q17QK8 SPRE_BOVIN 99.625 0.992537 1.00375 SPR - Sepiapterin reductase - Bos taurus (Bovine) - SPR gene Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. Taurus_UMD|evm.model.AC_000168.1.156 Q9Y2D4 EXC6B_HUMAN 98.836 0.993565 0.958076 EXOC6B - Exocyst complex component 6B - Homo sapiens (Human) - EXOC6B gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Taurus_UMD|evm.model.AC_000168.1.157 E1BHJ4 CP26B_BOVIN 100.000 0.996101 1.00195 CYP26B1 - Cytochrome P450 26B1 - Bos taurus (Bovine) - CYP26B1 gene Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints (By similarity). Taurus_UMD|evm.model.AC_000168.1.162 A6QQP7 DYSF_BOVIN 100.000 0.0137678 1.03417 DYSF - Dysferlin - Bos taurus (Bovine) - DYSF gene Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). Taurus_UMD|evm.model.AC_000168.1.163 Q14966 ZN638_HUMAN 81.272 0.961058 1.01264 ZNF638 - Zinc finger protein 638 - Homo sapiens (Human) - ZNF638 gene Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:8647861, PubMed:30487602). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). Taurus_UMD|evm.model.AC_000168.1.165 Q9ULR5 PAI2B_HUMAN 93.496 0.976 1.01626 PAIP2B - Polyadenylate-binding protein-interacting protein 2B - Homo sapiens (Human) - PAIP2B gene Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail. Taurus_UMD|evm.model.AC_000168.1.166 Q3SZM9 NAGK_BOVIN 100.000 0.994203 1.00291 NAGK - N-acetyl-D-glucosamine kinase - Bos taurus (Bovine) - NAGK gene Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Also has ManNAc kinase activity (By similarity). Taurus_UMD|evm.model.AC_000168.1.167 Q58DA4 TX261_BOVIN 100.000 0.873096 1.02073 TEX261 - Protein TEX261 - Bos taurus (Bovine) - TEX261 gene COPII-coated ER to Golgi transport vesicle, integral component of endoplasmic reticulum membrane, integral component of Golgi membrane, COPII receptor activity, endoplasmic reticulum to Golgi vesicle-mediated transport Taurus_UMD|evm.model.AC_000168.1.168 Q8N9V6 ANR53_HUMAN 69.266 0.80705 1.01698 ANKRD53 - Ankyrin repeat domain-containing protein 53 - Homo sapiens (Human) - ANKRD53 gene Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization. Taurus_UMD|evm.model.AC_000168.1.169 P31407 VATB1_BOVIN 99.805 0.996109 1.00195 ATP6V1B1 - V-type proton ATPase subunit B, kidney isoform - Bos taurus (Bovine) - ATP6V1B1 gene Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential for the proper assembly and activity of V-ATPase (By similarity). In renal intercalated cells, mediates secretion of protons (H+) into the urine thereby ensuring correct urinary acidification (By similarity). Required for optimal olfactory function by mediating the acidification of the nasal olfactory epithelium (By similarity). Taurus_UMD|evm.model.AC_000168.1.170 Q9UIW0 VAX2_HUMAN 85.172 0.989547 0.989655 VAX2 - Ventral anterior homeobox 2 - Homo sapiens (Human) - VAX2 gene Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina. Taurus_UMD|evm.model.AC_000168.1.171 Q9UJ71 CLC4K_HUMAN 68.997 0.987952 1.0122 CD207 - C-type lectin domain family 4 member K - Homo sapiens (Human) - CD207 gene Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. Taurus_UMD|evm.model.AC_000168.1.172 Q8N1N0 CLC4F_HUMAN 61.483 0.907895 1.03226 CLEC4F - C-type lectin domain family 4 member F - Homo sapiens (Human) - CLEC4F gene Receptor with an affinity for galactose and fucose. Could be involved in endocytosis (By similarity). Taurus_UMD|evm.model.AC_000168.1.173 O55208 FIGLA_MOUSE 68.852 0.607527 0.958763 Figla - Factor in the germline alpha - Mus musculus (Mouse) - Figla gene Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. Taurus_UMD|evm.model.AC_000168.1.174 P35612 ADDB_HUMAN 93.846 0.982069 0.998623 ADD2 - Beta-adducin - Homo sapiens (Human) - ADD2 gene Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. Taurus_UMD|evm.model.AC_000168.1.175 Q06922 TGFA_PIG 96.226 0.770732 1.28125 TGFA - Protransforming growth factor alpha precursor - Sus scrofa (Pig) - TGFA gene TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. Taurus_UMD|evm.model.AC_000168.1.176 Q5R8M1 STK38_PONAB 92.735 0.991489 0.505376 STK38 - Serine/threonine-protein kinase 38 - Pongo abelii (Sumatran orangutan) - STK38 gene Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity). Taurus_UMD|evm.model.AC_000168.1.177 A2VDV2 STK38_BOVIN 89.610 0.93865 0.350538 STK38 - Serine/threonine-protein kinase 38 - Bos taurus (Bovine) - STK38 gene Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity). Taurus_UMD|evm.model.AC_000168.1.178 Q2HJI3 F136A_BOVIN 100.000 0.878205 1.13043 FAM136A - Protein FAM136A - Bos taurus (Bovine) - FAM136A gene cytoplasm Taurus_UMD|evm.model.AC_000168.1.179 P80457 XDH_BOVIN 99.850 0.9985 1.00075 XDH - Xanthine dehydrogenase/oxidase - Bos taurus (Bovine) - XDH gene Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Taurus_UMD|evm.model.AC_000168.1.180 Q58DW5 RL5_BOVIN 98.052 0.950311 0.542088 RPL5 - 60S ribosomal protein L5 - Bos taurus (Bovine) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Taurus_UMD|evm.model.AC_000168.1.181 O18765 S5A2_PIG 95.625 0.987578 0.633858 SRD5A2 - 3-oxo-5-alpha-steroid 4-dehydrogenase 2 - Sus scrofa (Pig) - SRD5A2 gene Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). Taurus_UMD|evm.model.AC_000168.1.182 O18765 S5A2_PIG 88.421 0.930693 0.397638 SRD5A2 - 3-oxo-5-alpha-steroid 4-dehydrogenase 2 - Sus scrofa (Pig) - SRD5A2 gene Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). Taurus_UMD|evm.model.AC_000168.1.183 Q4R6D9 MEMO1_MACFA 98.577 0.958904 0.983165 MEMO1 - Protein MEMO1 - Macaca fascicularis (Crab-eating macaque) - MEMO1 gene May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Taurus_UMD|evm.model.AC_000168.1.184 Q9C005 DPY30_HUMAN 100.000 0.98 1.0101 DPY30 - Protein dpy-30 homolog - Homo sapiens (Human) - DPY30 gene As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Taurus_UMD|evm.model.AC_000168.1.185 A2VDN5 SPAST_BOVIN 100.000 0.544405 1.83388 SPAST - Spastin - Bos taurus (Bovine) - SPAST gene ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches. Taurus_UMD|evm.model.AC_000168.1.186 F1MHT9 NLRC4_BOVIN 99.799 0.957692 1.02262 NLRC4 - NLR family CARD domain-containing protein 4 - Bos taurus (Bovine) - NLRC4 gene Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. Taurus_UMD|evm.model.AC_000168.1.187 Q9BSR8 YIPF4_HUMAN 98.624 0.711475 1.25 YIPF4 - Protein YIPF4 - Homo sapiens (Human) - YIPF4 gene Involved in the maintenance of the Golgi structure. Taurus_UMD|evm.model.AC_000168.1.188 Q9NR09 BIRC6_HUMAN 96.318 0.99959 1.00391 BIRC6 - Baculoviral IAP repeat-containing protein 6 - Homo sapiens (Human) - BIRC6 gene Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Taurus_UMD|evm.model.AC_000168.1.189 Q17QZ7 TTC27_BOVIN 100.000 0.559299 0.876033 TTC27 - Tetratricopeptide repeat protein 27 - Bos taurus (Bovine) - TTC27 gene Taurus_UMD|evm.model.AC_000168.1.190 Q14766 LTBP1_HUMAN 87.153 0.992857 0.162696 LTBP1 - Latent-transforming growth factor beta-binding protein 1 precursor - Homo sapiens (Human) - LTBP1 gene Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Taurus_UMD|evm.model.AC_000168.1.191 Q14766 LTBP1_HUMAN 83.250 0.899351 0.715863 LTBP1 - Latent-transforming growth factor beta-binding protein 1 precursor - Homo sapiens (Human) - LTBP1 gene Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Taurus_UMD|evm.model.AC_000168.1.192 Q8IV61 GRP3_HUMAN 95.143 0.997143 1.01449 RASGRP3 - Ras guanyl-releasing protein 3 - Homo sapiens (Human) - RASGRP3 gene Guanine nucleotide exchange factor (GEF) for Ras and Rap1. Taurus_UMD|evm.model.AC_000168.1.193 Q8NCA5 FA98A_HUMAN 89.403 0.996032 0.972973 FAM98A - Protein FAM98A - Homo sapiens (Human) - FAM98A gene Positively stimulates PRMT1-induced protein arginine methylation (PubMed:28040436). Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Promotes colorectal cancer cell malignancy (PubMed:28040436). Taurus_UMD|evm.model.AC_000168.1.195 Q3ZCC3 TRAF6_BOVIN 91.882 0.914855 1.01845 TRAF6 - TNF receptor-associated factor 6 - Bos taurus (Bovine) - TRAF6 gene E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. Taurus_UMD|evm.model.AC_000168.1.196 Q5E995 RS6_BOVIN 41.447 0.815789 0.610442 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Taurus_UMD|evm.model.AC_000168.1.199 Q9UHY8 FEZ2_HUMAN 94.051 0.994286 0.991501 FEZ2 - Fasciculation and elongation protein zeta-2 - Homo sapiens (Human) - FEZ2 gene Involved in axonal outgrowth and fasciculation. Taurus_UMD|evm.model.AC_000168.1.201 Q95LI2 VITRN_BOVIN 97.546 0.996865 0.978528 VIT - Vitrin precursor - Bos taurus (Bovine) - VIT gene Promotes matrix assembly and cell adhesiveness. Plays a role in spinal cord formation by regulating the proliferation and differentiation of neural stem cells. Taurus_UMD|evm.model.AC_000168.1.202 O43815 STRN_HUMAN 93.943 0.997531 1.03846 STRN - Striatin - Homo sapiens (Human) - STRN gene Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling. Taurus_UMD|evm.model.AC_000168.1.203 Q9P2D3 HTR5B_HUMAN 97.344 0.9909 1.00821 HEATR5B - HEAT repeat-containing protein 5B - Homo sapiens (Human) - HEATR5B gene Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). Taurus_UMD|evm.model.AC_000168.1.204 Q2KI19 GPT11_BOVIN 100.000 0.977358 1.01923 GPATCH11 - G patch domain-containing protein 11 - Bos taurus (Bovine) - GPATCH11 gene kinetochore Taurus_UMD|evm.model.AC_000168.1.205 P19525 E2AK2_HUMAN 61.441 0.996255 0.969147 EIF2AK2 - Interferon-induced, double-stranded RNA-activated protein kinase - Homo sapiens (Human) - EIF2AK2 gene IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19507191, PubMed:19189853, PubMed:21123651, PubMed:21072047, PubMed:22948139, PubMed:23229543, PubMed:22381929). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:20171114, PubMed:19840259, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:22214662, PubMed:19229320). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). Taurus_UMD|evm.model.AC_000168.1.207 Q6WG18 ST6B1_PANTR 87.083 0.187797 4.16502 SULT6B1 - Sulfotransferase 6B1 - Pan troglodytes (Chimpanzee) - SULT6B1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity). Taurus_UMD|evm.model.AC_000168.1.208 Q2KHV5 NDUF7_BOVIN 99.546 0.995475 1.00227 NDUFAF7 - Protein arginine methyltransferase NDUFAF7, mitochondrial precursor - Bos taurus (Bovine) - NDUFAF7 gene Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex. Taurus_UMD|evm.model.AC_000168.1.209 O94806 KPCD3_HUMAN 97.640 0.997755 1.00112 PRKD3 - Serine/threonine-protein kinase D3 - Homo sapiens (Human) - PRKD3 gene Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). Taurus_UMD|evm.model.AC_000168.1.210 Q28120 QPCT_BOVIN 99.723 0.994475 1.00277 QPCT - Glutaminyl-peptide cyclotransferase precursor - Bos taurus (Bovine) - QPCT gene Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation (By similarity). Taurus_UMD|evm.model.AC_000168.1.211 P62907 RL10A_RAT 79.730 0.845238 0.387097 Rpl10a - 60S ribosomal protein L10a - Rattus norvegicus (Rat) - Rpl10a gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000168.1.212 Q9UKI2 BORG2_HUMAN 94.094 0.992157 1.00394 CDC42EP3 - Cdc42 effector protein 3 - Homo sapiens (Human) - CDC42EP3 gene Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Taurus_UMD|evm.model.AC_000168.1.213 Q2TBQ7 RMD2_BOVIN 100.000 0.921171 1.08293 RMDN2 - Regulator of microtubule dynamics protein 2 - Bos taurus (Bovine) - RMDN2 gene cytoplasm, mitochondrion, mitotic spindle pole, spindle microtubule, microtubule binding Taurus_UMD|evm.model.AC_000168.1.214 Q16678 CP1B1_HUMAN 81.952 0.996296 0.994475 CYP1B1 - Cytochrome P450 1B1 - Homo sapiens (Human) - CYP1B1 gene A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:20972997, PubMed:11555828, PubMed:12865317, PubMed:10681376, PubMed:15258110). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:20972997, PubMed:11555828, PubMed:12865317, PubMed:10681376, PubMed:15258110). Exhibits catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2- and 4-hydroxy E1 and E2. Displays a predominant hydroxylase activity toward E2 at the C-4 position (PubMed:11555828, PubMed:12865317). Metabolizes testosterone and progesterone to B or D ring hydroxylated metabolites (PubMed:10426814). May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376, PubMed:15258110). Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrE, that function as lipid mediators in the vascular system (PubMed:20972997). Additionally, displays dehydratase activity toward oxygenated eicosanoids hydroperoxyeicosatetraenoates (HpETEs). This activity is independent of cytochrome P450 reductase, NADPH, and O2 (PubMed:21068195). Also involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging products (PubMed:10426814). Plays an important role in retinal vascular development. Under hyperoxic O2 conditions, promotes retinal angiogenesis and capillary morphogenesis, likely by metabolizing the oxygenated products generated during the oxidative stress. Also, contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression (By similarity). Taurus_UMD|evm.model.AC_000168.1.215 Q95LN3 ATLA2_MACFA 97.818 0.876997 1.10796 ATL2 - Atlastin-2 - Macaca fascicularis (Crab-eating macaque) - ATL2 gene GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. Taurus_UMD|evm.model.AC_000168.1.217 Q9Y2Z4 SYYM_HUMAN 50.000 0.688312 0.161426 YARS2 - Tyrosine--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - YARS2 gene Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Taurus_UMD|evm.model.AC_000168.1.218 Q8WVV9 HNRLL_HUMAN 99.262 0.99631 1 HNRNPLL - Heterogeneous nuclear ribonucleoprotein L-like - Homo sapiens (Human) - HNRNPLL gene RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. Taurus_UMD|evm.model.AC_000168.1.219 Q58DT1 RL7_BOVIN 98.256 0.988439 0.697581 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Taurus_UMD|evm.model.AC_000168.1.220 Q5EA79 GALM_BOVIN 100.000 0.994169 1.00292 GALM - Galactose mutarotase - Bos taurus (Bovine) - GALM gene Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose. Taurus_UMD|evm.model.AC_000168.1.221 Q3T106 SRSF7_BOVIN 98.739 0.991632 1.01702 SRSF7 - Serine/arginine-rich splicing factor 7 - Bos taurus (Bovine) - SRSF7 gene Required for pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific (By similarity). Taurus_UMD|evm.model.AC_000168.1.222 Q5XHH9 TT39B_XENLA 48.348 0.964346 1.00512 ttc39b - Tetratricopeptide repeat protein 39B - Xenopus laevis (African clawed frog) - ttc39b gene May be involved in lipid metabolism. Taurus_UMD|evm.model.AC_000168.1.223 Q2KHW8 GEMI6_BOVIN 100.000 0.988024 1.00602 GEMIN6 - Gem-associated protein 6 - Bos taurus (Bovine) - GEMIN6 gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity). Taurus_UMD|evm.model.AC_000168.1.224 Q6P158 DHX57_HUMAN 91.838 0.978324 0.998557 DHX57 - Putative ATP-dependent RNA helicase DHX57 - Homo sapiens (Human) - DHX57 gene Probable ATP-binding RNA helicase. Taurus_UMD|evm.model.AC_000168.1.225 A8MVX0 ARG33_HUMAN 80.839 0.927938 1.06872 ARHGEF33 - Rho guanine nucleotide exchange factor 33 - Homo sapiens (Human) - ARHGEF33 gene May act as a guanine-nucleotide releasing factor. Taurus_UMD|evm.model.AC_000168.1.226 Q07889 SOS1_HUMAN 99.325 0.998501 1.00075 SOS1 - Son of sevenless homolog 1 - Homo sapiens (Human) - SOS1 gene Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). Taurus_UMD|evm.model.AC_000168.1.227 Q5MAI5 CDKL4_HUMAN 95.793 0.897959 0.905013 CDKL4 - Cyclin-dependent kinase-like 4 - Homo sapiens (Human) - CDKL4 gene nucleus, cyclin-dependent protein serine/threonine kinase activity, protein phosphorylation Taurus_UMD|evm.model.AC_000168.1.230 Q8NBL3 T178A_HUMAN 99.327 0.993289 1.00337 TMEM178A - Transmembrane protein 178A precursor - Homo sapiens (Human) - TMEM178A gene Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1. Taurus_UMD|evm.model.AC_000168.1.231 Q9BTF0 THUM2_HUMAN 75.498 0.994024 0.998012 THUMPD2 - THUMP domain-containing protein 2 - Homo sapiens (Human) - THUMPD2 gene tRNA (guanine) methyltransferase activity, tRNA methylation Taurus_UMD|evm.model.AC_000168.1.232 Q8IZP2 ST134_HUMAN 82.353 0.175532 0.783333 ST13P4 - Putative protein FAM10A4 - Homo sapiens (Human) - ST13P4 gene extracellular exosome, heat shock protein binding, chaperone cofactor-dependent protein refolding, protein-containing complex assembly Taurus_UMD|evm.model.AC_000168.1.234 Q5EAB0 MPZL2_BOVIN 77.241 0.866667 0.697674 MPZL2 - Myelin protein zero-like protein 2 precursor - Bos taurus (Bovine) - MPZL2 gene Mediates homophilic cell-cell adhesion. Taurus_UMD|evm.model.AC_000168.1.235 Q3T171 RL36_BOVIN 82.716 0.91954 0.828571 RPL36 - 60S ribosomal protein L36 - Bos taurus (Bovine) - RPL36 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000168.1.237 Q504Y2 PKDCC_HUMAN 95.068 0.894349 0.825558 PKDCC - Extracellular tyrosine-protein kinase PKDCC precursor - Homo sapiens (Human) - PKDCC gene Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity). Taurus_UMD|evm.model.AC_000168.1.239 Q9HC35 EMAL4_HUMAN 92.214 0.994965 1.01223 EML4 - Echinoderm microtubule-associated protein-like 4 - Homo sapiens (Human) - EML4 gene Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). Taurus_UMD|evm.model.AC_000168.1.240 Q3T061 COX7R_BOVIN 100.000 0.982609 1.00877 COX7A2L - Cytochrome c oxidase subunit 7A-related protein, mitochondrial precursor - Bos taurus (Bovine) - COX7A2L gene Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity). Taurus_UMD|evm.model.AC_000168.1.241 Q71U34 HSP7C_SAGOE 71.552 0.670588 0.263158 HSPA8 - Heat shock cognate 71 kDa protein - Saguinus oedipus (Cotton-top tamarin) - HSPA8 gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. Taurus_UMD|evm.model.AC_000168.1.242 Q8R523 KCNG3_RAT 98.198 0.924686 0.551963 Kcng3 - Potassium voltage-gated channel subfamily G member 3 - Rattus norvegicus (Rat) - Kcng3 gene Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Taurus_UMD|evm.model.AC_000168.1.243 Q8TAE7 KCNG3_HUMAN 97.015 0.985185 0.309633 KCNG3 - Potassium voltage-gated channel subfamily G member 3 - Homo sapiens (Human) - KCNG3 gene Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135). Taurus_UMD|evm.model.AC_000168.1.244 A6QL72 MTA3_BOVIN 99.313 0.935588 1.05254 MTA3 - Metastasis-associated protein MTA3 - Bos taurus (Bovine) - MTA3 gene Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6 (By similarity). Taurus_UMD|evm.model.AC_000168.1.246 Q8TDS5 OXER1_HUMAN 72.857 0.905013 0.895981 OXER1 - Oxoeicosanoid receptor 1 - Homo sapiens (Human) - OXER1 gene Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins. Taurus_UMD|evm.model.AC_000168.1.249 Q0VCA8 3HAO_BOVIN 100.000 0.685096 1.45455 HAAO - 3-hydroxyanthranilate 3,4-dioxygenase - Bos taurus (Bovine) - HAAO gene Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. Taurus_UMD|evm.model.AC_000168.1.251 P47974 TISD_HUMAN 85.830 0.995763 0.955466 ZFP36L2 - mRNA decay activator protein ZFP36L2 - Homo sapiens (Human) - ZFP36L2 gene Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. Taurus_UMD|evm.model.AC_000168.1.252 A8C750 THADA_CANLF 86.308 0.998459 0.999487 THADA - Thyroid adenoma-associated protein homolog - Canis lupus familiaris (Dog) - THADA gene cytosol, tRNA methylation Taurus_UMD|evm.model.AC_000168.1.253 Q8IVE3 PKHH2_HUMAN 94.039 0.99866 0.99933 PLEKHH2 - Pleckstrin homology domain-containing family H member 2 - Homo sapiens (Human) - PLEKHH2 gene In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia. Taurus_UMD|evm.model.AC_000168.1.254 Q32KV4 DC2L1_BOVIN 100.000 0.994318 1.00285 DYNC2LI1 - Cytoplasmic dynein 2 light intermediate chain 1 - Bos taurus (Bovine) - DYNC2LI1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles. Involved in the regulation of ciliary length. Taurus_UMD|evm.model.AC_000168.1.255 Q9H222 ABCG5_HUMAN 82.214 0.836641 1.00614 ABCG5 - ATP-binding cassette sub-family G member 5 - Homo sapiens (Human) - ABCG5 gene ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:27144356). Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11138003, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11138003, PubMed:15054092). The heterodimer with ABCG8 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356). Taurus_UMD|evm.model.AC_000168.1.256 Q9H221 ABCG8_HUMAN 81.899 0.997019 0.997028 ABCG8 - ATP-binding cassette sub-family G member 8 - Homo sapiens (Human) - ABCG8 gene ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092). The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356). Taurus_UMD|evm.model.AC_000168.1.257 P42704 LPPRC_HUMAN 80.532 0.996408 0.998565 LRPPRC - Leucine-rich PPR motif-containing protein, mitochondrial precursor - Homo sapiens (Human) - LRPPRC gene May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Taurus_UMD|evm.model.AC_000168.1.258 Q9H0F5 RNF38_HUMAN 97.630 0.990566 0.41165 RNF38 - E3 ubiquitin-protein ligase RNF38 - Homo sapiens (Human) - RNF38 gene Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme. Taurus_UMD|evm.model.AC_000168.1.259 O62830 PPM1B_BOVIN 98.760 0.995833 0.991736 PPM1B - Protein phosphatase 1B - Bos taurus (Bovine) - PPM1B gene Enzyme with a broad specificity. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). Taurus_UMD|evm.model.AC_000168.1.260 Q07837 SLC31_HUMAN 81.898 0.997085 1.00146 SLC3A1 - Neutral and basic amino acid transport protein rBAT - Homo sapiens (Human) - SLC3A1 gene Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule. Taurus_UMD|evm.model.AC_000168.1.261 Q5RAK4 PPCEL_PONAB 90.314 0.997275 1.00963 PREPL - Prolyl endopeptidase-like - Pongo abelii (Sumatran orangutan) - PREPL gene Serine peptidase whose precise substrate specificity remains unclear (By similarity). Does not cleave peptides after a arginine or lysine residue (By similarity). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (By similarity). May play a role in the regulation of synaptic vesicle exocytosis (By similarity). Taurus_UMD|evm.model.AC_000168.1.262 Q7Z624 CMKMT_HUMAN 76.380 0.993464 0.947368 CAMKMT - Calmodulin-lysine N-methyltransferase - Homo sapiens (Human) - CAMKMT gene Catalyzes the trimethylation of 'Lys-116' in calmodulin. Taurus_UMD|evm.model.AC_000168.1.263 O95343 SIX3_HUMAN 97.289 0.970326 1.01506 SIX3 - Homeobox protein SIX3 - Homo sapiens (Human) - SIX3 gene Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is TLE5 and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 functions also in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (By similarity). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway. Taurus_UMD|evm.model.AC_000168.1.264 Q62232 SIX2_MOUSE 98.322 0.993311 1.01014 Six2 - Homeobox protein SIX2 - Mus musculus (Mouse) - Six2 gene Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation (PubMed:20515681). During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1 (PubMed:19660448). During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway (PubMed:18321982). Also may be involved in limb tendon and ligament development (PubMed:7720577). Plays a role in cell proliferation and migration (By similarity). Taurus_UMD|evm.model.AC_000168.1.266 Q8N5C6 SRBD1_HUMAN 83.551 0.98029 0.968844 SRBD1 - S1 RNA-binding domain-containing protein 1 - Homo sapiens (Human) - SRBD1 gene mRNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000168.1.267 Q02156 KPCE_HUMAN 99.186 0.99729 1.00136 PRKCE - Protein kinase C epsilon type - Homo sapiens (Human) - PRKCE gene Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Taurus_UMD|evm.model.AC_000168.1.268 Q99814 EPAS1_HUMAN 86.797 0.997704 1.00115 EPAS1 - Endothelial PAS domain-containing protein 1 - Homo sapiens (Human) - EPAS1 gene Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity). Taurus_UMD|evm.model.AC_000168.1.269 Q2YDG1 TM247_BOVIN 99.052 0.836653 1.15668 Transmembrane protein 247 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000168.1.270 Q32LB7 VATE2_BOVIN 100.000 0.991189 1.00442 ATP6V1E2 - V-type proton ATPase subunit E 2 - Bos taurus (Bovine) - ATP6V1E2 gene Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity). Taurus_UMD|evm.model.AC_000168.1.271 P17081 RHOQ_HUMAN 100.000 0.990291 1.00488 RHOQ - Rho-related GTP-binding protein RhoQ precursor - Homo sapiens (Human) - RHOQ gene Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. Taurus_UMD|evm.model.AC_000168.1.272 Q07326 PIGF_HUMAN 90.411 0.990909 1.00457 PIGF - Phosphatidylinositol-glycan biosynthesis class F protein - Homo sapiens (Human) - PIGF gene Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI. Taurus_UMD|evm.model.AC_000168.1.273 Q9P021 CRIPT_HUMAN 100.000 0.980392 1.0099 CRIPT - Cysteine-rich PDZ-binding protein - Homo sapiens (Human) - CRIPT gene Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. Taurus_UMD|evm.model.AC_000168.1.274 Q29RN6 SOCS5_BOVIN 99.813 0.996276 1.00187 SOCS5 - Suppressor of cytokine signaling 5 - Bos taurus (Bovine) - SOCS5 gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling (By similarity). Taurus_UMD|evm.model.AC_000168.1.275 Q5R8Z6 MCFD2_PONAB 92.568 0.73 1.36986 MCFD2 - Multiple coagulation factor deficiency protein 2 homolog precursor - Pongo abelii (Sumatran orangutan) - MCFD2 gene The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Taurus_UMD|evm.model.AC_000168.1.276 Q9ULT0 TTC7A_HUMAN 93.007 0.997672 1.00117 TTC7A - Tetratricopeptide repeat protein 7A - Homo sapiens (Human) - TTC7A gene Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (By similarity). Taurus_UMD|evm.model.AC_000168.1.277 P0DP31 CALM3_RAT 95.973 0.426513 2.32886 Calm3 - Calmodulin-3 - Rattus norvegicus (Rat) - Calm3 gene Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Taurus_UMD|evm.model.AC_000168.1.278 Q3T0L5 EPCAM_BOVIN 98.726 0.993651 1.00318 EPCAM - Epithelial cell adhesion molecule precursor - Bos taurus (Bovine) - EPCAM gene May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). Taurus_UMD|evm.model.AC_000168.1.279 Q3MHE4 MSH2_BOVIN 100.000 0.997861 1.00107 MSH2 - DNA mismatch repair protein Msh2 - Bos taurus (Bovine) - MSH2 gene Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. Taurus_UMD|evm.model.AC_000168.1.280 Q9HB15 KCNKC_HUMAN 99.535 0.99536 1.00233 KCNK12 - Potassium channel subfamily K member 12 - Homo sapiens (Human) - KCNK12 gene Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel (By similarity). Taurus_UMD|evm.model.AC_000168.1.281 P52701 MSH6_HUMAN 91.930 0.998532 1.00147 MSH6 - DNA mismatch repair protein Msh6 - Homo sapiens (Human) - MSH6 gene Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. Taurus_UMD|evm.model.AC_000168.1.282 Q7TSL3 FBX11_RAT 99.763 0.909385 1.09964 Fbxo11 - F-box only protein 11 - Rattus norvegicus (Rat) - Fbxo11 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53LOG. Taurus_UMD|evm.model.AC_000168.1.283 P62752 RL23A_RAT 63.636 0.857143 0.628205 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000168.1.285 P32314 FOXN2_HUMAN 91.344 0.995455 1.02088 FOXN2 - Forkhead box protein N2 - Homo sapiens (Human) - FOXN2 gene Binds to the purine-rich region in HTLV-I LTR. Taurus_UMD|evm.model.AC_000168.1.286 Q6ZMI0 PPR21_HUMAN 94.872 0.997439 1.00128 PPP1R21 - Protein phosphatase 1 regulatory subunit 21 - Homo sapiens (Human) - PPP1R21 gene Putative regulator of protein phosphatase 1 (PP1) activity (PubMed:19389623). May play a role in the endosomal sorting process or in endosome maturation pathway (PubMed:30520571). Taurus_UMD|evm.model.AC_000168.1.287 Q9Y6Q2 STON1_HUMAN 86.685 0.997271 0.997279 STON1 - Stonin-1 - Homo sapiens (Human) - STON1 gene May be involved in the endocytic machinery. Taurus_UMD|evm.model.AC_000168.1.288 Q9UNN4 TF2AY_HUMAN 80.738 0.546067 0.930962 GTF2A1L - TFIIA-alpha and beta-like factor - Homo sapiens (Human) - GTF2A1L gene May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. Taurus_UMD|evm.model.AC_000168.1.289 Q28005 LSHR_BOVIN 96.434 0.99705 0.96719 LHCGR - Lutropin-choriogonadotropic hormone receptor precursor - Bos taurus (Bovine) - LHCGR gene Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Taurus_UMD|evm.model.AC_000168.1.290 P35376 FSHR_BOVIN 91.925 0.975369 0.876259 FSHR - Follicle-stimulating hormone receptor precursor - Bos taurus (Bovine) - FSHR gene G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. Taurus_UMD|evm.model.AC_000168.1.291 Q9ULB1 NRX1A_HUMAN 96.277 0.999127 0.77522 NRXN1 - Neurexin-1 precursor - Homo sapiens (Human) - NRXN1 gene Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity). Taurus_UMD|evm.model.AC_000168.1.292 Q4L180 FIL1L_HUMAN 96.000 0.993333 0.132159 FILIP1L - Filamin A-interacting protein 1-like - Homo sapiens (Human) - FILIP1L gene Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. Taurus_UMD|evm.model.AC_000168.1.293 Q96MG7 NSE3_HUMAN 77.863 0.909091 0.470395 NSMCE3 - Non-structural maintenance of chromosomes element 3 homolog - Homo sapiens (Human) - NSMCE3 gene Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity). Taurus_UMD|evm.model.AC_000168.1.294 Q9CPR8 NSE3_MOUSE 60.550 0.981308 0.383513 Nsmce3 - Non-structural maintenance of chromosomes element 3 homolog - Mus musculus (Mouse) - Nsmce3 gene Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (PubMed:14593116). Taurus_UMD|evm.model.AC_000168.1.296 Q96FN9 DTD2_HUMAN 88.690 0.988166 1.00595 DTD2 - D-aminoacyl-tRNA deacylase 2 - Homo sapiens (Human) - DTD2 gene Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408). Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408). Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity). Taurus_UMD|evm.model.AC_000168.1.297 Q08DV6 ASB3_BOVIN 99.810 0.996198 1.0019 ASB3 - Ankyrin repeat and SOCS box protein 3 - Bos taurus (Bovine) - ASB3 gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B (By similarity). Taurus_UMD|evm.model.AC_000168.1.298 Q9CQG1 CHAC2_MOUSE 94.382 0.936508 1.0618 Chac2 - Putative glutathione-specific gamma-glutamylcyclotransferase 2 - Mus musculus (Mouse) - Chac2 gene Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide (PubMed:27913623). Acts specifically on glutathione, but not on other gamma-glutamyl peptides (By similarity). Taurus_UMD|evm.model.AC_000168.1.299 Q5R8S4 ERLEC_PONAB 97.101 0.995868 1.00207 ERLEC1 - Endoplasmic reticulum lectin 1 precursor - Pongo abelii (Sumatran orangutan) - ERLEC1 gene Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins (By similarity). Taurus_UMD|evm.model.AC_000168.1.300 O95800 GPR75_HUMAN 93.704 0.91511 1.09074 GPR75 - Probable G-protein coupled receptor 75 - Homo sapiens (Human) - GPR75 gene G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. Taurus_UMD|evm.model.AC_000168.1.301 F1MKX4 PSME4_BOVIN 99.675 0.998915 0.999458 PSME4 - Proteasome activator complex subunit 4 - Bos taurus (Bovine) - PSME4 gene Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks (By similarity). Taurus_UMD|evm.model.AC_000168.1.302 P07033 ACYP2_BOVIN 95.455 0.477941 1.37374 ACYP2 - Acylphosphatase-2 - Bos taurus (Bovine) - ACYP2 gene Its physiological role is not yet clear. Taurus_UMD|evm.model.AC_000168.1.303 A6QQL5 CB073_BOVIN 100.000 0.993127 1.00345 Uncharacterized protein C2orf73 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000168.1.304 Q01082 SPTB2_HUMAN 99.069 0.999154 1 SPTBN1 - Spectrin beta chain, non-erythrocytic 1 - Homo sapiens (Human) - SPTBN1 gene Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Taurus_UMD|evm.model.AC_000168.1.305 Q6ZMW3 EMAL6_HUMAN 97.966 0.960883 1.01839 EML6 - Echinoderm microtubule-associated protein-like 6 - Homo sapiens (Human) - EML6 gene May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. Taurus_UMD|evm.model.AC_000168.1.306 Q9NQC3 RTN4_HUMAN 80.948 0.998308 0.991611 RTN4 - Reticulon-4 - Homo sapiens (Human) - RTN4 gene Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:27619977, PubMed:25612671, PubMed:24262037). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977, PubMed:25612671, PubMed:24262037, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). Taurus_UMD|evm.model.AC_000168.1.307 Q4R6I5 CLHC1_MACFA 80.245 0.933007 1.04437 CLHC1 - Clathrin heavy chain linker domain-containing protein 1 - Macaca fascicularis (Crab-eating macaque) - CLHC1 gene Taurus_UMD|evm.model.AC_000168.1.308 P62979 RS27A_HUMAN 100.000 0.987261 1.00641 RPS27A - Ubiquitin-40S ribosomal protein S27a precursor - Homo sapiens (Human) - RPS27A gene Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Taurus_UMD|evm.model.AC_000168.1.309 P46198 IF2M_BOVIN 100.000 0.997253 1.00138 MTIF2 - Translation initiation factor IF-2, mitochondrial precursor - Bos taurus (Bovine) - MTIF2 gene One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. Taurus_UMD|evm.model.AC_000168.1.310 A1A4Q2 PRXD1_BOVIN 100.000 0.636704 1.5614 PRORSD1 - Prolyl-tRNA synthetase associated domain-containing protein 1 - Bos taurus (Bovine) - PRORSD1 gene Taurus_UMD|evm.model.AC_000168.1.311 Q3V6T2 GRDN_HUMAN 95.998 0.99893 0.999466 CCDC88A - Girdin - Homo sapiens (Human) - CCDC88A gene Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:20462955, PubMed:16139227, PubMed:19211784, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). Taurus_UMD|evm.model.AC_000168.1.312 Q3ZC62 CFA36_BOVIN 91.254 0.994186 1.09904 CFAP36 - Cilia- and flagella-associated protein 36 - Bos taurus (Bovine) - CFAP36 gene May act as an effector for ARL3. Taurus_UMD|evm.model.AC_000168.1.313 Q922R5 P4R3B_MOUSE 96.341 0.997564 1.00122 Ppp4r3b - Serine/threonine-protein phosphatase 4 regulatory subunit 3B - Mus musculus (Mouse) - Ppp4r3b gene Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers (By similarity). Taurus_UMD|evm.model.AC_000168.1.314 Q8TCS8 PNPT1_HUMAN 91.816 0.996173 1.00128 PNPT1 - Polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor - Homo sapiens (Human) - PNPT1 gene RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA. Taurus_UMD|evm.model.AC_000168.1.315 Q7YQD7 FBLN3_MACFA 73.092 0.640212 0.766734 EFEMP1 - EGF-containing fibulin-like extracellular matrix protein 1 precursor - Macaca fascicularis (Crab-eating macaque) - EFEMP1 gene Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth (By similarity). Taurus_UMD|evm.model.AC_000168.1.316 Q96PX6 CC85A_HUMAN 96.667 0.0675991 0.775769 CCDC85A - Coiled-coil domain-containing protein 85A - Homo sapiens (Human) - CCDC85A gene May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family. Taurus_UMD|evm.model.AC_000168.1.318 Q86Y07 VRK2_HUMAN 74.539 0.898671 1.18504 VRK2 - Serine/threonine-protein kinase VRK2 - Homo sapiens (Human) - VRK2 gene Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant. Taurus_UMD|evm.model.AC_000168.1.319 Q9NW38 FANCL_HUMAN 87.701 0.992 1 FANCL - E3 ubiquitin-protein ligase FANCL - Homo sapiens (Human) - FANCL gene Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026). Also mediates monoubiquitination of FANCI (PubMed:19589784). May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. Taurus_UMD|evm.model.AC_000168.1.320 P23527 H2B1O_HUMAN 94.340 0.944444 0.428571 H2BC17 - Histone H2B type 1-O - Homo sapiens (Human) - H2BC17 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000168.1.322 Q5E9S8 CDIN1_BOVIN 89.535 0.977011 0.309609 CDIN1 - CDAN1-interacting nuclease 1 - Bos taurus (Bovine) - CDIN1 gene Plays a role in erythroid cell differentiation. Taurus_UMD|evm.model.AC_000168.1.323 Q9H165 BC11A_HUMAN 99.641 0.997608 1.0012 BCL11A - B-cell lymphoma/leukemia 11A - Homo sapiens (Human) - BCL11A gene Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:29606353, PubMed:26375765). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). Taurus_UMD|evm.model.AC_000168.1.325 Q9BWT3 PAPOG_HUMAN 94.602 0.997301 1.00679 PAPOLG - Poly(A) polymerase gamma - Homo sapiens (Human) - PAPOLG gene Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. Taurus_UMD|evm.model.AC_000168.1.326 Q04864 REL_HUMAN 79.775 0.993243 0.956381 REL - Proto-oncogene c-Rel - Homo sapiens (Human) - REL gene Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. Taurus_UMD|evm.model.AC_000168.1.327 Q3MIT2 PUS10_HUMAN 76.350 0.899818 1.03781 PUS10 - tRNA pseudouridine synthase Pus10 - Homo sapiens (Human) - PUS10 gene Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm (PubMed:31819270). In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs (PubMed:30530625, PubMed:31819270). tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs (PubMed:30530625). In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity (PubMed:31819270). Binds pri-miRNAs (PubMed:31819270). Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage (PubMed:14527409, PubMed:19712588). Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death (PubMed:19712588). Taurus_UMD|evm.model.AC_000168.1.328 Q0P5B1 PEX13_BOVIN 100.000 0.99505 1.00248 PEX13 - Peroxisomal membrane protein PEX13 - Bos taurus (Bovine) - PEX13 gene Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (By similarity). Taurus_UMD|evm.model.AC_000168.1.330 Q6NSI8 K1841_HUMAN 93.750 0.940678 0.164345 KIAA1841 - Uncharacterized protein KIAA1841 - Homo sapiens (Human) - KIAA1841 gene Taurus_UMD|evm.model.AC_000168.1.331 Q6NSI8 K1841_HUMAN 90.928 0.995876 0.675487 KIAA1841 - Uncharacterized protein KIAA1841 - Homo sapiens (Human) - KIAA1841 gene Taurus_UMD|evm.model.AC_000168.1.332 P16383 GCFC2_HUMAN 77.139 0.994891 1.00256 GCFC2 - Intron Large complex component GCFC2 - Homo sapiens (Human) - GCFC2 gene Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693). Taurus_UMD|evm.model.AC_000168.1.333 Q2HJI0 RM19_BOVIN 99.658 0.993174 1.00342 MRPL19 - 39S ribosomal protein L19, mitochondrial precursor - Bos taurus (Bovine) - MRPL19 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000168.1.334 P10096 G3P_BOVIN 82.397 0.960938 0.768769 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Bos taurus (Bovine) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Taurus_UMD|evm.model.AC_000168.1.335 Q9H8M9 EVA1A_HUMAN 87.234 0.985816 0.927632 EVA1A - Protein eva-1 homolog A - Homo sapiens (Human) - EVA1A gene Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis. Taurus_UMD|evm.model.AC_000168.1.336 Q53LP3 SWAHC_HUMAN 81.818 0.669251 0.737143 SOWAHC - Ankyrin repeat domain-containing protein SOWAHC - Homo sapiens (Human) - SOWAHC gene Taurus_UMD|evm.model.AC_000168.1.337 Q2KJB1 SEP10_BOVIN 100.000 0.899384 1.07506 SEPTIN10 - Septin-10 - Bos taurus (Bovine) - SEPTIN10 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Taurus_UMD|evm.model.AC_000168.1.338 Q8TEJ3 SH3R3_HUMAN 76.077 0.997633 0.95805 SH3RF3 - E3 ubiquitin-protein ligase SH3RF3 - Homo sapiens (Human) - SH3RF3 gene Has E3 ubiquitin-protein ligase activity. Taurus_UMD|evm.model.AC_000168.1.339 Q9UNE0 EDAR_HUMAN 85.523 0.598131 1.67188 EDAR - Tumor necrosis factor receptor superfamily member EDAR precursor - Homo sapiens (Human) - EDAR gene Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. Taurus_UMD|evm.model.AC_000168.1.340 Q95JJ5 CC138_MACFA 72.532 0.926667 1.12782 CCDC138 - Coiled-coil domain-containing protein 138 - Macaca fascicularis (Crab-eating macaque) - CCDC138 gene Taurus_UMD|evm.model.AC_000168.1.341 P48820 RBP2_BOVIN 99.631 0.351492 2.8424 RANBP2 - E3 SUMO-protein ligase RanBP2 - Bos taurus (Bovine) - RANBP2 gene E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. Taurus_UMD|evm.model.AC_000168.1.342 P48059 LIMS1_HUMAN 98.154 0.95858 1.04 LIMS1 - LIM and senescent cell antigen-like-containing domain protein 1 - Homo sapiens (Human) - LIMS1 gene Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation. Taurus_UMD|evm.model.AC_000168.1.343 Q99666 RGPD5_HUMAN 78.767 0.0848665 0.954674 RGPD5 - RANBP2-like and GRIP domain-containing protein 5/6 - Homo sapiens (Human) - RGPD5 gene cytoplasm, nuclear pore, NLS-bearing protein import into nucleus Taurus_UMD|evm.model.AC_000168.1.344 O75897 ST1C4_HUMAN 74.497 0.99 0.993377 SULT1C4 - Sulfotransferase 1C4 - Homo sapiens (Human) - SULT1C4 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). Taurus_UMD|evm.model.AC_000168.1.345 O75897 ST1C4_HUMAN 79.461 0.989967 0.990066 SULT1C4 - Sulfotransferase 1C4 - Homo sapiens (Human) - SULT1C4 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). Taurus_UMD|evm.model.AC_000168.1.346 Q9WUW8 ST1C2_RAT 79.443 0.760638 1.27027 Sult1c2 - Sulfotransferase 1C2 - Rattus norvegicus (Rat) - Sult1c2 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. Taurus_UMD|evm.model.AC_000168.1.347 P50237 ST1C1_RAT 86.513 0.993443 1.00329 Sult1c1 - Sulfotransferase 1C1 - Rattus norvegicus (Rat) - Sult1c1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines (By similarity). Taurus_UMD|evm.model.AC_000168.1.348 Q9GZV3 SC5A7_HUMAN 90.517 0.996558 1.00172 SLC5A7 - High affinity choline transporter 1 - Homo sapiens (Human) - SLC5A7 gene Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent. Taurus_UMD|evm.model.AC_000168.1.352 A5D7T4 SIAT2_BOVIN 100.000 0.995968 1.00202 ST6GAL2 - Beta-galactoside alpha-2,6-sialyltransferase 2 - Bos taurus (Bovine) - ST6GAL2 gene Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids. Taurus_UMD|evm.model.AC_000168.1.353 Q9UHC7 MKRN1_HUMAN 82.902 0.510638 0.780083 MKRN1 - E3 ubiquitin-protein ligase makorin-1 - Homo sapiens (Human) - MKRN1 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. Taurus_UMD|evm.model.AC_000168.1.354 Q5R885 UXS1_PONAB 96.905 0.995249 1.00238 UXS1 - UDP-glucuronic acid decarboxylase 1 - Pongo abelii (Sumatran orangutan) - UXS1 gene Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity). Taurus_UMD|evm.model.AC_000168.1.355 Q32KM8 AUGN_BOVIN 99.320 0.986486 1.0068 ECRG4 - Augurin precursor - Bos taurus (Bovine) - ECRG4 gene Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (By similarity). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (By similarity). Taurus_UMD|evm.model.AC_000168.1.356 Q9DCR2 AP3S1_MOUSE 81.250 0.378973 2.11917 Ap3s1 - AP-3 complex subunit sigma-1 - Mus musculus (Mouse) - Ap3s1 gene Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Taurus_UMD|evm.model.AC_000168.1.357 O43639 NCK2_HUMAN 89.474 0.994695 0.992105 NCK2 - Cytoplasmic protein NCK2 - Homo sapiens (Human) - NCK2 gene Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Taurus_UMD|evm.model.AC_000168.1.358 P68373 TBA1C_MOUSE 87.097 0.190625 0.712695 Tuba1c - Tubulin alpha-1C chain - Mus musculus (Mouse) - Tuba1c gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Taurus_UMD|evm.model.AC_000168.1.360 P38584 TTL_BOVIN 99.735 0.994709 1.00265 TTL - Tubulin--tyrosine ligase - Bos taurus (Bovine) - TTL gene Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin. Taurus_UMD|evm.model.AC_000168.1.361 Q5REE8 RPA2_PONAB 93.838 0.998239 1 POLR1B - DNA-directed RNA polymerase I subunit RPA2 - Pongo abelii (Sumatran orangutan) - POLR1B gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. Taurus_UMD|evm.model.AC_000168.1.362 Q9BSY4 CHCH5_HUMAN 86.239 0.5625 1.74545 CHCHD5 - Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 - Homo sapiens (Human) - CHCHD5 gene mitochondrion Taurus_UMD|evm.model.AC_000168.1.363 O97596 S20A1_FELCA 96.833 0.970674 1.00147 Slc20a1 - Sodium-dependent phosphate transporter 1 - Felis catus (Cat) - Slc20a1 gene Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. Taurus_UMD|evm.model.AC_000168.1.364 Q86YG4 NT5D4_HUMAN 64.407 0.87013 0.899533 NT5DC4 - 5'-nucleotidase domain-containing protein 4 - Homo sapiens (Human) - NT5DC4 gene 5'-nucleotidase activity Taurus_UMD|evm.model.AC_000168.1.366 A5PK21 CKP2L_BOVIN 100.000 0.997315 1.00134 CKAP2L - Cytoskeleton-associated protein 2-like - Bos taurus (Bovine) - CKAP2L gene Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells. Taurus_UMD|evm.model.AC_000168.1.367 P08831 IL1A_BOVIN 100.000 0.917526 1.08582 IL1A - Interleukin-1 alpha precursor - Bos taurus (Bovine) - IL1A gene Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Taurus_UMD|evm.model.AC_000168.1.368 P84089 ERH_MOUSE 98.077 0.980952 1.00962 Erh - Enhancer of rudimentary homolog - Mus musculus (Mouse) - Erh gene May have a role in the cell cycle. Taurus_UMD|evm.model.AC_000168.1.369 P09428 IL1B_BOVIN 99.624 0.992509 1.00376 IL1B - Interleukin-1 beta precursor - Bos taurus (Bovine) - IL1B gene Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Taurus_UMD|evm.model.AC_000168.1.370 Q9NZH6 IL37_HUMAN 61.650 0.990291 0.944954 IL37 - Interleukin-37 precursor - Homo sapiens (Human) - IL37 gene Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. Taurus_UMD|evm.model.AC_000168.1.371 Q9NZH8 IL36G_HUMAN 67.089 0.885714 1.0355 IL36G - Interleukin-36 gamma precursor - Homo sapiens (Human) - IL36G gene Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. Taurus_UMD|evm.model.AC_000168.1.372 Q9UHA7 IL36A_HUMAN 67.308 0.786802 1.24684 IL36A - Interleukin-36 alpha precursor - Homo sapiens (Human) - IL36A gene Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung. Taurus_UMD|evm.model.AC_000168.1.373 Q9NZH7 IL36B_HUMAN 67.647 0.482014 0.847561 IL36B - Interleukin-36 beta precursor - Homo sapiens (Human) - IL36B gene Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. Taurus_UMD|evm.model.AC_000168.1.374 Q9UBH0 I36RA_HUMAN 83.871 0.987179 1.00645 IL36RN - Interleukin-36 receptor antagonist protein - Homo sapiens (Human) - IL36RN gene Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. Taurus_UMD|evm.model.AC_000168.1.375 Q8WWZ1 IL1FA_HUMAN 86.093 0.980392 1.00658 IL1F10 - Interleukin-1 family member 10 - Homo sapiens (Human) - IL1F10 gene Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2. Taurus_UMD|evm.model.AC_000168.1.376 O77482 IL1RA_BOVIN 100.000 0.988571 1.00575 IL1RN - Interleukin-1 receptor antagonist protein precursor - Bos taurus (Bovine) - IL1RN gene Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Taurus_UMD|evm.model.AC_000168.1.377 Q8NDX1 PSD4_HUMAN 71.535 0.998043 0.967803 PSD4 - PH and SEC7 domain-containing protein 4 - Homo sapiens (Human) - PSD4 gene Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. Taurus_UMD|evm.model.AC_000168.1.378 P47240 PAX8_CANLF 98.475 0.995633 0.997821 PAX8 - Paired box protein Pax-8 - Canis lupus familiaris (Dog) - PAX8 gene Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development. Taurus_UMD|evm.model.AC_000168.1.381 P62268 RS23_RAT 99.301 0.986111 1.00699 Rps23 - 40S ribosomal protein S23 - Rattus norvegicus (Rat) - Rps23 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy. Taurus_UMD|evm.model.AC_000168.1.382 P06310 KV230_HUMAN 71.667 0.937008 1.05833 IGKV2-30 - Immunoglobulin kappa variable 2-30 precursor - Homo sapiens (Human) - IGKV2-30 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Taurus_UMD|evm.model.AC_000168.1.383 P04432 KVD39_HUMAN 78.788 0.784 1.06838 IGKV1D-39 - Immunoglobulin kappa variable 1D-39 precursor - Homo sapiens (Human) - IGKV1D-39 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Taurus_UMD|evm.model.AC_000168.1.384 A0A0A0MRZ8 KVD11_HUMAN 55.435 0.771186 1.02609 IGKV3D-11 - Immunoglobulin kappa variable 3D-11 precursor - Homo sapiens (Human) - IGKV3D-11 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Taurus_UMD|evm.model.AC_000168.1.385 P01834 IGKC_HUMAN 59.048 0.920354 1.05607 IGKC - Immunoglobulin kappa constant - Homo sapiens (Human) - IGKC gene Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000168.1.386 O43482 MS18B_HUMAN 72.549 0.933333 0.458515 OIP5 - Protein Mis18-beta - Homo sapiens (Human) - OIP5 gene Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. Taurus_UMD|evm.model.AC_000168.1.387 Q3T186 RPIA_BOVIN 100.000 0.856678 1.16288 RPIA - Ribose-5-phosphate isomerase - Bos taurus (Bovine) - RPIA gene intracellular membrane-bounded organelle, ribose-5-phosphate isomerase activity, D-ribose metabolic process, pentose-phosphate shunt, non-oxidative branch Taurus_UMD|evm.model.AC_000168.1.388 Q9NZJ5 E2AK3_HUMAN 89.744 0.975806 1 EIF2AK3 - Eukaryotic translation initiation factor 2-alpha kinase 3 precursor - Homo sapiens (Human) - EIF2AK3 gene Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:33384352). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity). Taurus_UMD|evm.model.AC_000168.1.389 A5PJD8 TEX37_BOVIN 98.333 0.98895 1.00556 TEX37 - Testis-expressed sequence 37 protein - Bos taurus (Bovine) - TEX37 gene cytoplasm Taurus_UMD|evm.model.AC_000168.1.390 A8MTJ6 FOXI3_HUMAN 87.629 0.755906 0.302381 FOXI3 - Forkhead box protein I3 - Homo sapiens (Human) - FOXI3 gene Possible transcriptional factor. Taurus_UMD|evm.model.AC_000168.1.391 A8MTJ6 FOXI3_HUMAN 84.375 0.99308 0.688095 FOXI3 - Forkhead box protein I3 - Homo sapiens (Human) - FOXI3 gene Possible transcriptional factor. Taurus_UMD|evm.model.AC_000168.1.392 P62979 RS27A_HUMAN 74.400 0.974576 0.75641 RPS27A - Ubiquitin-40S ribosomal protein S27a precursor - Homo sapiens (Human) - RPS27A gene Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Taurus_UMD|evm.model.AC_000168.1.393 Q5RFE6 THNS2_PONAB 87.110 0.989691 1.00207 THNSL2 - Threonine synthase-like 2 - Pongo abelii (Sumatran orangutan) - THNSL2 gene Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity). Taurus_UMD|evm.model.AC_000168.1.394 P80425 FABPL_BOVIN 100.000 0.984375 1.00787 FABP1 - Fatty acid-binding protein, liver - Bos taurus (Bovine) - FABP1 gene Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Taurus_UMD|evm.model.AC_000168.1.395 Q8NB12 SMYD1_HUMAN 95.510 0.995927 1.00204 SMYD1 - Histone-lysine N-methyltransferase SMYD1 - Homo sapiens (Human) - SMYD1 gene Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis. Taurus_UMD|evm.model.AC_000168.1.396 Q17QQ9 KRCC1_BOVIN 100.000 0.992248 1.00389 KRCC1 - Lysine-rich coiled-coil protein 1 - Bos taurus (Bovine) - KRCC1 gene Taurus_UMD|evm.model.AC_000168.1.397 Q92146 TBP_TRIGA 80.198 0.993421 1.00662 TBP - TATA-box-binding protein - Trimeresurus gramineus (Bamboo pit viper) - TBP gene General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Taurus_UMD|evm.model.AC_000168.1.398 Q3V0C1 ZMAT1_MOUSE 57.500 0.157258 0.347339 Zmat1 - Zinc finger matrin-type protein 1 - Mus musculus (Mouse) - Zmat1 gene Taurus_UMD|evm.model.AC_000168.1.399 P79336 CD8B_FELCA 65.979 0.909953 1.00476 CD8B - T-cell surface glycoprotein CD8 beta chain precursor - Felis catus (Cat) - CD8B gene Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells. Taurus_UMD|evm.model.AC_000168.1.400 P31783 CD8A_BOVIN 98.760 0.99177 1.00413 CD8A - T-cell surface glycoprotein CD8 alpha chain precursor - Bos taurus (Bovine) - CD8A gene Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. Taurus_UMD|evm.model.AC_000168.1.401 Q80YQ8 RMD5A_MOUSE 100.000 0.994898 1.00256 Rmnd5a - E3 ubiquitin-protein ligase RMND5A - Mus musculus (Mouse) - Rmnd5a gene Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. Taurus_UMD|evm.model.AC_000168.1.402 O00237 RN103_HUMAN 97.372 0.997085 1.00146 RNF103 - E3 ubiquitin-protein ligase RNF103 - Homo sapiens (Human) - RNF103 gene Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway. Taurus_UMD|evm.model.AC_000168.1.403 Q58CS7 CHMP3_BOVIN 100.000 0.991031 1.0045 CHMP3 - Charged multivesicular body protein 3 - Bos taurus (Bovine) - CHMP3 gene Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor (By similarity). Taurus_UMD|evm.model.AC_000168.1.404 Q9Y4C1 KDM3A_HUMAN 92.523 0.980669 1.01817 KDM3A - Lysine-specific demethylase 3A - Homo sapiens (Human) - KDM3A gene Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. Taurus_UMD|evm.model.AC_000168.1.405 Q9H902 REEP1_HUMAN 89.767 0.607955 1.75124 REEP1 - Receptor expression-enhancing protein 1 - Homo sapiens (Human) - REEP1 gene Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (PubMed:20200447). May play a role in long-term axonal maintenance (PubMed:24478229). Taurus_UMD|evm.model.AC_000168.1.406 Q3SZA9 RM35_BOVIN 100.000 0.989418 1.00532 MRPL35 - 39S ribosomal protein L35, mitochondrial precursor - Bos taurus (Bovine) - MRPL35 gene mitochondrial inner membrane, mitochondrion Taurus_UMD|evm.model.AC_000168.1.407 Q16891 MIC60_HUMAN 89.021 0.98543 0.996042 IMMT - MICOS complex subunit MIC60 precursor - Homo sapiens (Human) - IMMT gene Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180). Taurus_UMD|evm.model.AC_000168.1.408 Q2KI62 PTCD3_BOVIN 100.000 0.997097 1.00145 PTCD3 - Pentatricopeptide repeat domain-containing protein 3, mitochondrial precursor - Bos taurus (Bovine) - PTCD3 gene Mitochondrial RNA-binding protein that has a role in mitochondrial translation. Taurus_UMD|evm.model.AC_000168.1.409 O95602 RPA1_HUMAN 87.449 0.998801 0.969767 POLR1A - DNA-directed RNA polymerase I subunit RPA1 - Homo sapiens (Human) - POLR1A gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Taurus_UMD|evm.model.AC_000168.1.410 Q70D51 SIAT9_BOVIN 99.762 0.995249 1.00238 ST3GAL5 - Lactosylceramide alpha-2,3-sialyltransferase - Bos taurus (Bovine) - ST3GAL5 gene Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1 Taurus_UMD|evm.model.AC_000168.1.411 Q96SQ7 ATOH8_HUMAN 89.130 0.993711 0.990654 ATOH8 - Protein atonal homolog 8 - Homo sapiens (Human) - ATOH8 gene Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (PubMed:24236640). Regulates endothelial cell proliferation, migration and tube-like structures formation (PubMed:24463812). Modulates endothelial cell differentiation through NOS3 (PubMed:24463812). May be implicated in specification and differentiation of neuronal cell lineages in the brain (By similarity). May participate in kidney development and may be involved in podocyte differentiation (By similarity). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (By similarity). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (By similarity). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (PubMed:24236640). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (By similarity). Taurus_UMD|evm.model.AC_000168.1.412 Q29075 NKL_PIG 59.200 0.843537 1.13953 NKL - Antimicrobial peptide NK-lysin precursor - Sus scrofa (Pig) - NKL gene May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. Taurus_UMD|evm.model.AC_000168.1.413 Q2NL21 DJC11_BOVIN 88.193 0.996176 0.935599 DNAJC11 - DnaJ homolog subfamily C member 11 - Bos taurus (Bovine) - DNAJC11 gene Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex. Taurus_UMD|evm.model.AC_000168.1.414 Q29075 NKL_PIG 57.778 0.872549 0.790698 NKL - Antimicrobial peptide NK-lysin precursor - Sus scrofa (Pig) - NKL gene May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. Taurus_UMD|evm.model.AC_000168.1.415 Q29075 NKL_PIG 54.264 0.874126 1.10853 NKL - Antimicrobial peptide NK-lysin precursor - Sus scrofa (Pig) - NKL gene May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. Taurus_UMD|evm.model.AC_000168.1.416 P15781 PSPB_BOVIN 100.000 0.994652 1.00268 SFTPB - Pulmonary surfactant-associated protein B precursor - Bos taurus (Bovine) - SFTPB gene Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. Taurus_UMD|evm.model.AC_000168.1.417 Q53GS9 SNUT2_HUMAN 97.876 0.996466 1.00177 USP39 - U4/U6.U5 tri-snRNP-associated protein 2 - Homo sapiens (Human) - USP39 gene Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity (PubMed:18728397). Taurus_UMD|evm.model.AC_000168.1.418 A4IFR8 CB068_BOVIN 100.000 0.988024 1.00602 UPF0561 protein C2orf68 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000168.1.419 Q86TG1 T150A_HUMAN 92.308 0.991935 0.915129 TMEM150A - Transmembrane protein 150A - Homo sapiens (Human) - TMEM150A gene Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex (PubMed:25608530). Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:25608530). May also play a role in fasting-induced catabolism (By similarity). Taurus_UMD|evm.model.AC_000168.1.420 Q3T0W3 RN181_BOVIN 100.000 0.987013 1.00654 RNF181 - E3 ubiquitin-protein ligase RNF181 - Bos taurus (Bovine) - RNF181 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Taurus_UMD|evm.model.AC_000168.1.421 Q2KHY2 VAMP5_BOVIN 100.000 0.982906 1.00862 VAMP5 - Vesicle-associated membrane protein 5 - Bos taurus (Bovine) - VAMP5 gene May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking. Taurus_UMD|evm.model.AC_000168.1.422 Q3T0Y8 VAMP8_BOVIN 100.000 0.649007 1.51 VAMP8 - Vesicle-associated membrane protein 8 - Bos taurus (Bovine) - VAMP8 gene SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Participates also in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (By similarity). Taurus_UMD|evm.model.AC_000168.1.423 Q07175 VKGC_BOVIN 100.000 0.997245 0.957784 GGCX - Vitamin K-dependent gamma-carboxylase - Bos taurus (Bovine) - GGCX gene Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. Taurus_UMD|evm.model.AC_000168.1.424 Q5R5H1 METK2_PONAB 99.241 0.994949 1.00253 MAT2A - S-adenosylmethionine synthase isoform type-2 - Pongo abelii (Sumatran orangutan) - MAT2A gene Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. Taurus_UMD|evm.model.AC_000168.1.425 Q7Z4S9 SH2D6_HUMAN 79.562 0.375691 2.06857 SH2D6 - SH2 domain-containing protein 6 - Homo sapiens (Human) - SH2D6 gene cytoplasm, intracellular signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway Taurus_UMD|evm.model.AC_000168.1.426 Q865V6 CAPG_BOVIN 100.000 0.994286 1.00287 CAPG - Macrophage-capping protein - Bos taurus (Bovine) - CAPG gene Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA (By similarity). Taurus_UMD|evm.model.AC_000168.1.427 Q58DT5 ELMD3_BOVIN 88.235 0.995098 1.07087 ELMOD3 - ELMO domain-containing protein 3 - Bos taurus (Bovine) - ELMOD3 gene Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity. Taurus_UMD|evm.model.AC_000168.1.428 Q6NUM9 RETST_HUMAN 81.081 0.968852 1 RETSAT - All-trans-retinol 13,14-reductase precursor - Homo sapiens (Human) - RETSAT gene Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation. Taurus_UMD|evm.model.AC_000168.1.429 P19814 TGON3_RAT 67.568 0.472131 0.854342 Ttgn1 - Trans-Golgi network integral membrane protein TGN38 precursor - Rattus norvegicus (Rat) - Ttgn1 gene endosome, Golgi apparatus, integral component of membrane, trans-Golgi network, trans-Golgi network transport vesicle, Golgi to endosome transport Taurus_UMD|evm.model.AC_000168.1.430 Q9HCS4 TF7L1_HUMAN 96.516 0.994792 0.979592 TCF7L1 - Transcription factor 7-like 1 - Homo sapiens (Human) - TCF7L1 gene Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. Taurus_UMD|evm.model.AC_000168.1.431 Q1LZE1 KCMF1_BOVIN 97.113 0.994667 0.984252 KCMF1 - E3 ubiquitin-protein ligase KCMF1 - Bos taurus (Bovine) - KCMF1 gene Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. Taurus_UMD|evm.model.AC_000168.1.432 Q9C0G6 DYH6_HUMAN 90.574 0.941399 0.95214 DNAH6 - Dynein axonemal heavy chain 6 - Homo sapiens (Human) - DNAH6 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Taurus_UMD|evm.model.AC_000168.1.433 Q58DR8 SUCA_BOVIN 99.700 0.994012 0.965318 SUCLG1 - Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - SUCLG1 gene Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. Taurus_UMD|evm.model.AC_000168.1.435 Q3MHN8 TRM5_BOVIN 85.714 0.932886 0.299799 TRMT5 - tRNA (guanine(37)-N1)-methyltransferase - Bos taurus (Bovine) - TRMT5 gene Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. Taurus_UMD|evm.model.AC_000168.1.436 P14381 YTX2_XENLA 32.673 0.568182 0.134557 Transposon TX1 uncharacterized 149 kDa protein - Xenopus laevis (African clawed frog) Taurus_UMD|evm.model.AC_000168.1.437 P08548 LIN1_NYCCO 74.558 0.682809 0.327778 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Taurus_UMD|evm.model.AC_000168.1.439 P03360 POL_AVIRE 42.972 0.995935 0.427083 pol - Gag-Pol polyprotein - Avian reticuloendotheliosis virus - pol gene The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell. Taurus_UMD|evm.model.AC_000168.1.440 Q5R416 CTNA2_PONAB 99.748 0.878049 0.498343 CTNNA2 - Catenin alpha-2 - Pongo abelii (Sumatran orangutan) - CTNNA2 gene May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation. Taurus_UMD|evm.model.AC_000168.1.442 P31621 ENV_JSRV 36.364 0.526012 0.281301 env - Envelope glycoprotein precursor - Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) - env gene The envelope proteins induce cell transformation leading to ovine pulmonary adenocarcinoma (OPA), a contagious lung cancer of sheep and goat. They bind to the HYAL2 receptor for cell entry. Env proteins probably do not act as oncogenes by themselves, but may rather liberate an oncogenic factor that would normally be negatively regulated. One mechanism of transformation seems to involve activation of the phosphoinositide-3-OH kinase (PI3K)/Akt pathway but does not involve the virus receptor HYAL2, and the other seems to involve Env binding to HYAL2, HYAL2 degradation, and activation of the MST1R receptor tyrosine kinase, which is normally suppressed by HYAL2. Taurus_UMD|evm.model.AC_000168.1.443 P23132 LITH_BOVIN 70.520 0.976879 0.988571 PTP - Lithostathine precursor - Bos taurus (Bovine) - PTP gene Might act as an inhibitor of spontaneous calcium carbonate precipitation. Taurus_UMD|evm.model.AC_000168.1.444 P23132 LITH_BOVIN 100.000 0.988636 1.00571 PTP - Lithostathine precursor - Bos taurus (Bovine) - PTP gene Might act as an inhibitor of spontaneous calcium carbonate precipitation. Taurus_UMD|evm.model.AC_000168.1.445 P63221 RS21_PIG 86.747 0.88172 1.12048 RPS21 - 40S ribosomal protein S21 - Sus scrofa (Pig) - RPS21 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, ribosome binding, structural constituent of ribosome, cytoplasmic translation, endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000168.1.447 Q86VH4 LRRT4_HUMAN 96.318 0.996132 0.876271 LRRTM4 - Leucine-rich repeat transmembrane neuronal protein 4 precursor - Homo sapiens (Human) - LRRTM4 gene May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity). Taurus_UMD|evm.model.AC_000168.1.448 Q5RCS8 VATD_PONAB 78.632 0.990291 0.417004 ATP6V1D - V-type proton ATPase subunit D - Pongo abelii (Sumatran orangutan) - ATP6V1D gene Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). Taurus_UMD|evm.model.AC_000168.1.449 Q96KR7 PHAR3_HUMAN 88.506 0.905759 0.341682 PHACTR3 - Phosphatase and actin regulator 3 - Homo sapiens (Human) - PHACTR3 gene nucleoplasm, actin binding, actin cytoskeleton organization Taurus_UMD|evm.model.AC_000168.1.450 Q80XG9 LRRT4_MOUSE 89.189 0.760417 0.162712 Lrrtm4 - Leucine-rich repeat transmembrane neuronal protein 4 precursor - Mus musculus (Mouse) - Lrrtm4 gene May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity). Taurus_UMD|evm.model.AC_000168.1.451 A8MZ97 CB074_HUMAN 61.856 0.989247 0.958763 C2orf74 - Uncharacterized protein C2orf74 - Homo sapiens (Human) - C2orf74 gene Taurus_UMD|evm.model.AC_000168.1.452 A6QQC0 AHSA2_BOVIN 99.598 0.740299 1.28846 AHSA2 - Activator of 90 kDa heat shock protein ATPase homolog 2 - Bos taurus (Bovine) - AHSA2 gene Co-chaperone that stimulates HSP90 ATPase activity. Taurus_UMD|evm.model.AC_000168.1.453 Q70CQ2 UBP34_HUMAN 98.478 0.999436 1.00056 USP34 - Ubiquitin carboxyl-terminal hydrolase 34 - Homo sapiens (Human) - USP34 gene Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Taurus_UMD|evm.model.AC_000168.1.454 Q6P5F9 XPO1_MOUSE 99.160 0.998134 1.00093 Xpo1 - Exportin-1 - Mus musculus (Mouse) - Xpo1 gene Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap (By similarity). Taurus_UMD|evm.model.AC_000168.1.455 Q5RFQ0 FCF1_PONAB 96.970 0.987952 0.838384 FCF1 - rRNA-processing protein FCF1 homolog - Pongo abelii (Sumatran orangutan) - FCF1 gene Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. Taurus_UMD|evm.model.AC_000168.1.457 Q3B820 F161A_HUMAN 76.190 0.975976 1.00909 FAM161A - Protein FAM161A - Homo sapiens (Human) - FAM161A gene Involved in ciliogenesis. Taurus_UMD|evm.model.AC_000168.1.458 Q2T9X2 TCPD_BOVIN 99.631 0.996317 1.00185 CCT4 - T-complex protein 1 subunit delta - Bos taurus (Bovine) - CCT4 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Taurus_UMD|evm.model.AC_000168.1.459 Q2M2T5 COMD1_BOVIN 99.468 0.989418 1.00532 COMMD1 - COMM domain-containing protein 1 - Bos taurus (Bovine) - COMMD1 gene Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitination of SLC12A2. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes. Promotes CFTR cell surface expression through regulation of its ubiquitination. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1. Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner. Taurus_UMD|evm.model.AC_000168.1.460 Q9NY97 B3GN2_HUMAN 88.665 0.994975 1.00252 B3GNT2 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 - Homo sapiens (Human) - B3GNT2 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. Taurus_UMD|evm.model.AC_000168.1.461 A4FUY9 TMM17_BOVIN 100.000 0.98995 1.00505 TMEM17 - Transmembrane protein 17 - Bos taurus (Bovine) - TMEM17 gene Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). Taurus_UMD|evm.model.AC_000168.1.462 Q8NDI1 EHBP1_HUMAN 89.805 0.998172 0.888708 EHBP1 - EH domain-binding protein 1 - Homo sapiens (Human) - EHBP1 gene May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). Taurus_UMD|evm.model.AC_000168.1.464 P32242 OTX1_HUMAN 97.465 0.808219 1.23729 OTX1 - Homeobox protein OTX1 - Homo sapiens (Human) - OTX1 gene Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. Taurus_UMD|evm.model.AC_000168.1.465 Q2M2T7 RT24_BOVIN 95.808 0.988095 1.00599 MRPS24 - 28S ribosomal protein S24, mitochondrial precursor - Bos taurus (Bovine) - MRPS24 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000168.1.466 O95876 FRITZ_HUMAN 82.310 0.64486 0.573727 WDPCP - WD repeat-containing and planar cell polarity effector protein fritz homolog - Homo sapiens (Human) - WDPCP gene Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). Taurus_UMD|evm.model.AC_000168.1.467 Q3T145 MDHC_BOVIN 100.000 0.99403 1.00299 MDH1 - Malate dehydrogenase, cytoplasmic - Bos taurus (Bovine) - MDH1 gene Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Taurus_UMD|evm.model.AC_000168.1.468 O00370 LORF2_HUMAN 30.645 0.787097 0.121569 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000168.1.469 Q10126 YSM6_CAEEL 35.849 0.390977 0.476703 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000168.1.471 Q07130 UGPA_BOVIN 100.000 0.995984 0.980315 UGP2 - UTP--glucose-1-phosphate uridylyltransferase - Bos taurus (Bovine) - UGP2 gene UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. Taurus_UMD|evm.model.AC_000168.1.472 Q9P1Q0 VPS54_HUMAN 95.906 0.997955 1.00102 VPS54 - Vacuolar protein sorting-associated protein 54 - Homo sapiens (Human) - VPS54 gene Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061). Taurus_UMD|evm.model.AC_000168.1.473 Q96FA3 PELI1_HUMAN 99.522 0.995227 1.00239 PELI1 - E3 ubiquitin-protein ligase pellino homolog 1 - Homo sapiens (Human) - PELI1 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609). Taurus_UMD|evm.model.AC_000168.1.475 Q8VED9 LEGL_MOUSE 100.000 0.988439 1.00581 Lgalsl - Galectin-related protein - Mus musculus (Mouse) - Lgalsl gene Does not bind lactose, and may not bind carbohydrates. Taurus_UMD|evm.model.AC_000168.1.476 Q6ULP2 AFTIN_HUMAN 87.540 0.997856 0.996795 AFTPH - Aftiphilin - Homo sapiens (Human) - AFTPH gene Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). Taurus_UMD|evm.model.AC_000168.1.477 Q9JJG5 SRTD2_MOUSE 79.560 0.993671 1.02265 Sertad2 - SERTA domain-containing protein 2 - Mus musculus (Mouse) - Sertad2 gene Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. Taurus_UMD|evm.model.AC_000168.1.479 P20065 TYB4_MOUSE 97.826 0.737705 1.22 Tmsb4x - Thymosin beta-4 - Mus musculus (Mouse) - Tmsb4x gene Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Taurus_UMD|evm.model.AC_000168.1.480 A2VDL4 SATT_BOVIN 100.000 0.996234 1.00189 SLC1A4 - Neutral amino acid transporter A - Bos taurus (Bovine) - SLC1A4 gene Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. Taurus_UMD|evm.model.AC_000168.1.481 Q5RCQ2 CEP68_PONAB 70.580 0.985526 1.01198 CEP68 - Centrosomal protein of 68 kDa - Pongo abelii (Sumatran orangutan) - CEP68 gene Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase. Taurus_UMD|evm.model.AC_000168.1.482 Q6NYB7 RAB1A_RAT 100.000 0.990291 1.00488 Rab1A - Ras-related protein Rab-1A - Rattus norvegicus (Rat) - Rab1A gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21303926). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21303926). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed:21303926). Regulates the level of CASR present at the cell membrane (By similarity). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (By similarity). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity). Taurus_UMD|evm.model.AC_000168.1.483 P61161 ARP2_MOUSE 97.716 0.994819 0.979695 Actr2 - Actin-related protein 2 - Mus musculus (Mouse) - Actr2 gene ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Taurus_UMD|evm.model.AC_000168.1.484 Q7Z698 SPRE2_HUMAN 97.608 0.995215 1 SPRED2 - Sprouty-related, EVH1 domain-containing protein 2 - Homo sapiens (Human) - SPRED2 gene Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). Taurus_UMD|evm.model.AC_000168.1.485 Q96PP9 GBP4_HUMAN 68.519 0.218107 0.379688 GBP4 - Guanylate-binding protein 4 - Homo sapiens (Human) - GBP4 gene Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity). Taurus_UMD|evm.model.AC_000168.1.488 Q6UXQ4 CB066_HUMAN 76.190 0.805825 0.880342 C2orf66 - Uncharacterized protein C2orf66 precursor - Homo sapiens (Human) - C2orf66 gene Taurus_UMD|evm.model.AC_000168.1.489 Q3ZEJ6 SPA33_BOVIN 99.375 0.929825 0.416058 SERPINA3-3 - Serpin A3-3 precursor - Bos taurus (Bovine) - SERPINA3-3 gene Serine protease inhibitor. Strongly inhibits elastase and trypsin stoichiometrically at the molar ratio of 1:1. Acts as a moderate inhibitor of plasmin and chymotrypsin. Does not inhibit thrombin, urokinase, kallikrein, tissue plasminogen activator, cathepsin G or the cysteine proteases papain, cathepsin B or cathepsin L. Taurus_UMD|evm.model.AC_000168.1.490 Q08DI1 ETAA1_BOVIN 100.000 0.997778 1.00111 ETAA1 - Ewing's tumor-associated antigen 1 homolog - Bos taurus (Bovine) - ETAA1 gene Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets. Taurus_UMD|evm.model.AC_000168.1.492 Q32PE4 C1D_BOVIN 100.000 0.740741 1.34043 C1D - Nuclear nucleic acid-binding protein C1D - Bos taurus (Bovine) - C1D gene Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). Taurus_UMD|evm.model.AC_000168.1.493 Q29RZ9 WDR92_BOVIN 100.000 0.994413 1.0028 DNAAF10 - Dynein axonemal assembly factor 10 - Bos taurus (Bovine) - DNAAF10 gene Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm. Taurus_UMD|evm.model.AC_000168.1.494 Q7YRD0 PNO1_BOVIN 100.000 0.992095 1.00397 PNO1 - RNA-binding protein PNO1 - Bos taurus (Bovine) - PNO1 gene Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. Taurus_UMD|evm.model.AC_000168.1.495 P63100 CANB1_RAT 100.000 0.988304 1.00588 Ppp3r1 - Calcineurin subunit B type 1 - Rattus norvegicus (Rat) - Ppp3r1 gene Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Taurus_UMD|evm.model.AC_000168.1.496 Q17QM9 CNRP1_BOVIN 100.000 0.987879 1.0061 CNRIP1 - CB1 cannabinoid receptor-interacting protein 1 - Bos taurus (Bovine) - CNRIP1 gene Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Taurus_UMD|evm.model.AC_000168.1.497 P08567 PLEK_HUMAN 94.571 0.994302 1.00286 PLEK - Pleckstrin - Homo sapiens (Human) - PLEK gene Major protein kinase C substrate of platelets. Taurus_UMD|evm.model.AC_000168.1.498 Q5FWF7 FBX48_HUMAN 86.452 0.987179 1.00645 FBXO48 - F-box only protein 48 - Homo sapiens (Human) - FBXO48 gene SCF ubiquitin ligase complex, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Taurus_UMD|evm.model.AC_000168.1.499 Q8IW19 APLF_HUMAN 75.124 0.448198 0.868885 APLF - Aprataxin and PNK-like factor - Homo sapiens (Human) - APLF gene Nuclease involved in single-strand and double-strand DNA break repair (PubMed:17353262, PubMed:17396150). Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (PubMed:17353262, PubMed:17396150, PubMed:21211721). Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (PubMed:17353262, PubMed:17396150). Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721). Taurus_UMD|evm.model.AC_000168.1.500 Q8SPN2 PKR1_BOVIN 99.746 0.915888 1.08906 PROKR1 - Prokineticin receptor 1 - Bos taurus (Bovine) - PROKR1 gene Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy (By similarity). Taurus_UMD|evm.model.AC_000168.1.501 P42331 RHG25_HUMAN 89.009 0.99688 0.993798 ARHGAP25 - Rho GTPase-activating protein 25 - Homo sapiens (Human) - ARHGAP25 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000168.1.502 O95393 BMP10_HUMAN 89.858 0.995294 1.00236 BMP10 - Bone morphogenetic protein 10 precursor - Homo sapiens (Human) - BMP10 gene Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. Taurus_UMD|evm.model.AC_000168.1.503 D2XPP7 GKN3_PIG 85.380 0.982558 0.950276 GKN3 - Gastrokine-3 precursor - Sus scrofa (Pig) - GKN3 gene May inhibit gastric epithelial cell proliferation. Taurus_UMD|evm.model.AC_000168.1.504 Q86XP6 GKN2_HUMAN 73.913 0.989189 1.00543 GKN2 - Gastrokine-2 precursor - Homo sapiens (Human) - GKN2 gene extracellular space, regulation of cell population proliferation Taurus_UMD|evm.model.AC_000168.1.505 Q8HYA9 GKN1_PIG 76.796 0.782609 1.16162 GKN1 - Gastrokine-1 precursor - Sus scrofa (Pig) - GKN1 gene Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. Taurus_UMD|evm.model.AC_000168.1.506 Q9H6X2 ANTR1_HUMAN 97.518 0.99646 1.00177 ANTXR1 - Anthrax toxin receptor 1 precursor - Homo sapiens (Human) - ANTXR1 gene Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. Taurus_UMD|evm.model.AC_000168.1.507 P82808 GFPT1_RAT 91.579 0.988848 0.790015 Gfpt1 - Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 - Rattus norvegicus (Rat) - Gfpt1 gene Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1. Taurus_UMD|evm.model.AC_000168.1.508 Q9UMS0 NFU1_HUMAN 92.913 0.992126 1 NFU1 - NFU1 iron-sulfur cluster scaffold homolog, mitochondrial precursor - Homo sapiens (Human) - NFU1 gene Iron-sulfur cluster scaffold protein which can assemble [4Fe-4S] clusters and deliver them to target proteins. Taurus_UMD|evm.model.AC_000168.1.509 F1MH24 AAK1_BOVIN 99.892 0.712635 1.35632 AAK1 - AP2-associated protein kinase 1 - Bos taurus (Bovine) - AAK1 gene Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Preferentially, may phosphorylate substrates on threonine residues. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. Taurus_UMD|evm.model.AC_000168.1.510 P13214 ANXA4_BOVIN 100.000 0.99375 1.00313 ANXA4 - Annexin A4 - Bos taurus (Bovine) - ANXA4 gene May play a role in alveolar type II cells through interaction with the surfactant protein SFTPA1 (SP-A). Taurus_UMD|evm.model.AC_000168.1.511 Q96IK5 GMCL1_HUMAN 93.774 0.973435 1.0233 GMCL1 - Germ cell-less protein-like 1 - Homo sapiens (Human) - GMCL1 gene Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). Taurus_UMD|evm.model.AC_000168.1.512 Q8WVK2 SNR27_HUMAN 100.000 0.987179 1.00645 SNRNP27 - U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein - Homo sapiens (Human) - SNRNP27 gene May play a role in mRNA splicing. Taurus_UMD|evm.model.AC_000168.1.513 Q05195 MAD1_HUMAN 95.946 0.991031 1.00905 MXD1 - Max dimerization protein 1 - Homo sapiens (Human) - MXD1 gene Component of a transcriptional repressor complex together with MAX (PubMed:8425218). In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (PubMed:8425218). Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (PubMed:8425218). Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (PubMed:12837246). Taurus_UMD|evm.model.AC_000168.1.514 Q53RT3 APRV1_HUMAN 86.434 0.988281 0.746356 ASPRV1 - Retroviral-like aspartic protease 1 precursor - Homo sapiens (Human) - ASPRV1 gene Protease responsible for filaggrin processing, essential for the maintenance of a proper epidermis organization. Taurus_UMD|evm.model.AC_000168.1.515 O19048 PCBP1_RABIT 100.000 0.994398 1.00281 PCBP1 - Poly(rC)-binding protein 1 - Oryctolagus cuniculus (Rabbit) - PCBP1 gene Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Taurus_UMD|evm.model.AC_000168.1.517 Q3SYX3 CB042_BOVIN 100.000 0.996522 1.00174 Uncharacterized protein C2orf42 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000168.1.519 P31483 TIA1_HUMAN 98.187 0.994832 1.00259 TIA1 - Nucleolysin TIA-1 isoform p40 - Homo sapiens (Human) - TIA1 gene Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. Taurus_UMD|evm.model.AC_000168.1.520 Q95KC9 PCYOX_MACFA 79.418 0.943026 1.00792 PCYOX1 - Prenylcysteine oxidase precursor - Macaca fascicularis (Crab-eating macaque) - PCYOX1 gene Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (By similarity). Taurus_UMD|evm.model.AC_000168.1.521 P62309 RUXG_MOUSE 100.000 0.974026 1.01316 Snrpg - Small nuclear ribonucleoprotein G - Mus musculus (Mouse) - Snrpg gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. Taurus_UMD|evm.model.AC_000168.1.522 Q9NZN3 EHD3_HUMAN 97.009 0.996269 1.00187 EHD3 - EH domain-containing protein 3 - Homo sapiens (Human) - EHD3 gene ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250). Taurus_UMD|evm.model.AC_000168.1.523 A8MX76 CAN14_HUMAN 79.576 0.932203 1.03509 CAPN14 - Calpain-14 - Homo sapiens (Human) - CAPN14 gene Calcium-regulated non-lysosomal thiol-protease. Taurus_UMD|evm.model.AC_000168.1.524 Q96FL9 GLT14_HUMAN 90.217 0.996383 1.00181 GALNT14 - Polypeptide N-acetylgalactosaminyltransferase 14 - Homo sapiens (Human) - GALNT14 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney. Taurus_UMD|evm.model.AC_000168.1.525 Q5BK10 CAN13_RAT 66.119 0.99701 1.0015 Capn13 - Calpain-13 - Rattus norvegicus (Rat) - Capn13 gene Probable non-lysosomal thiol-protease. Taurus_UMD|evm.model.AC_000168.1.526 Q6UWP7 LCLT1_HUMAN 91.223 0.994695 0.910628 LCLAT1 - Lysocardiolipin acyltransferase 1 - Homo sapiens (Human) - LCLAT1 gene Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:16620771). Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (PubMed:19075029). Required for establishment of the hematopoietic and endothelial lineages (By similarity). Taurus_UMD|evm.model.AC_000168.1.527 A5PJU8 LBH_BOVIN 100.000 0.981132 1.00952 LBH - Protein LBH - Bos taurus (Bovine) - LBH gene Transcriptional activator. Taurus_UMD|evm.model.AC_000168.1.528 Q5RDU7 YPEL5_PONAB 100.000 0.983607 1.00826 YPEL5 - Protein yippee-like 5 - Pongo abelii (Sumatran orangutan) - YPEL5 gene Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for normal cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000168.1.529 Q9UM73 ALK_HUMAN 80.882 0.91129 0.22963 ALK - ALK tyrosine kinase receptor precursor - Homo sapiens (Human) - ALK gene Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. Thinness gene involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Taurus_UMD|evm.model.AC_000168.1.530 Q9UM73 ALK_HUMAN 91.304 0.6 0.117284 ALK - ALK tyrosine kinase receptor precursor - Homo sapiens (Human) - ALK gene Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. Thinness gene involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Taurus_UMD|evm.model.AC_000168.1.531 Q9UM73 ALK_HUMAN 91.774 0.833036 0.691358 ALK - ALK tyrosine kinase receptor precursor - Homo sapiens (Human) - ALK gene Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. Thinness gene involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Taurus_UMD|evm.model.AC_000168.1.532 Q8N3C7 CLIP4_HUMAN 91.348 0.997163 1 CLIP4 - CAP-Gly domain-containing linker protein 4 - Homo sapiens (Human) - CLIP4 gene cytoplasm, intracellular membrane-bounded organelle, microtubule plus-end, nucleus, microtubule plus-end binding, cytoplasmic microtubule organization Taurus_UMD|evm.model.AC_000168.1.533 A6NGG8 PCARE_HUMAN 64.346 0.994648 1.01553 PCARE - Photoreceptor cilium actin regulator - Homo sapiens (Human) - PCARE gene Plays an essential role for normal photoreceptor cell maintenance and vision. Taurus_UMD|evm.model.AC_000168.1.534 Q6ZUX3 TGRM2_HUMAN 79.053 0.996976 0.973503 TOGARAM2 - TOG array regulator of axonemal microtubules protein 2 - Homo sapiens (Human) - TOGARAM2 gene cilium, cytoplasmic microtubule, microtubule organizing center, mitotic spindle, spindle microtubule, microtubule binding, microtubule cytoskeleton organization, mitotic spindle assembly Taurus_UMD|evm.model.AC_000168.1.535 Q15061 WDR43_HUMAN 90.029 0.997067 1.00739 WDR43 - WD repeat-containing protein 43 - Homo sapiens (Human) - WDR43 gene Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity). Taurus_UMD|evm.model.AC_000168.1.536 Q9BVS5 TR61B_HUMAN 73.237 0.995781 0.993711 TRMT61B - tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial precursor - Homo sapiens (Human) - TRMT61B gene Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function (PubMed:27631568). In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537). Taurus_UMD|evm.model.AC_000168.1.537 Q6GQL2 PP1B_XENLA 100.000 0.527434 1.72783 ppp1cb - Serine/threonine-protein phosphatase PP1-beta catalytic subunit - Xenopus laevis (African clawed frog) - ppp1cb gene Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity (By similarity). Taurus_UMD|evm.model.AC_000168.1.538 Q6P1J6 PLB1_HUMAN 68.502 0.994582 0.886145 PLB1 - Phospholipase B1, membrane-associated precursor - Homo sapiens (Human) - PLB1 gene Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates (By similarity). Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (By similarity). May also hydrolyze long chain retinyl esters such as retinyl palmitate (By similarity). May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (By similarity). Taurus_UMD|evm.model.AC_000168.1.539 P15408 FOSL2_HUMAN 97.248 0.993902 1.00613 FOSL2 - Fos-related antigen 2 - Homo sapiens (Human) - FOSL2 gene Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts. Taurus_UMD|evm.model.AC_000168.1.540 A6QQW8 BABA2_BOVIN 100.000 0.994792 1.00261 BABAM2 - BRISC and BRCA1-A complex member 2 - Bos taurus (Bovine) - BABAM2 gene Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect. Taurus_UMD|evm.model.AC_000168.1.541 Q9H477 RBSK_HUMAN 88.615 0.993865 1.01242 RBKS - Ribokinase - Homo sapiens (Human) - RBKS gene Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. Taurus_UMD|evm.model.AC_000168.1.542 Q9BWU0 NADAP_HUMAN 84.367 0.997301 0.930905 SLC4A1AP - Kanadaptin - Homo sapiens (Human) - SLC4A1AP gene intracellular membrane-bounded organelle, nucleoplasm, plasma membrane, mRNA binding Taurus_UMD|evm.model.AC_000168.1.543 O94864 ST65G_HUMAN 96.602 0.995157 0.997585 SUPT7L - STAGA complex 65 subunit gamma - Homo sapiens (Human) - SUPT7L gene nucleoplasm, nucleus, STAGA complex, transcription coactivator activity, histone H3 acetylation, maintenance of protein location in nucleus Taurus_UMD|evm.model.AC_000168.1.544 A4FUD1 GPN1_BOVIN 100.000 0.994652 1.00268 GPN1 - GPN-loop GTPase 1 - Bos taurus (Bovine) - GPN1 gene Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA. Taurus_UMD|evm.model.AC_000168.1.545 Q6ZUS5 CC121_HUMAN 51.938 0.365714 1.25899 CCDC121 - Coiled-coil domain-containing protein 121 - Homo sapiens (Human) - CCDC121 gene Taurus_UMD|evm.model.AC_000168.1.546 Q6ZUS5 CC121_HUMAN 45.926 0.943662 0.510791 CCDC121 - Coiled-coil domain-containing protein 121 - Homo sapiens (Human) - CCDC121 gene Taurus_UMD|evm.model.AC_000168.1.547 A4FV61 ZN512_BOVIN 100.000 0.996479 1.00176 ZNF512 - Zinc finger protein 512 - Bos taurus (Bovine) - ZNF512 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000168.1.548 Q68DN1 CB016_HUMAN 59.235 0.288552 2.99395 C2orf16 - Uncharacterized protein C2orf16 - Homo sapiens (Human) - C2orf16 gene extracellular exosome, nucleus Taurus_UMD|evm.model.AC_000168.1.549 Q14397 GCKR_HUMAN 62.531 0.919137 0.5936 GCKR - Glucokinase regulatory protein - Homo sapiens (Human) - GCKR gene Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:23621087, PubMed:23733961). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10456334). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed:23621087, PubMed:23733961). Taurus_UMD|evm.model.AC_000168.1.550 A6QPL2 FNDC4_BOVIN 89.941 0.969512 0.713043 FNDC4 - Fibronectin type III domain-containing protein 4 precursor - Bos taurus (Bovine) - FNDC4 gene Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. Taurus_UMD|evm.model.AC_000168.1.551 Q9JKU3 IF172_RAT 97.370 0.998857 1.00057 Ift172 - Intraflagellar transport protein 172 homolog - Rattus norvegicus (Rat) - Ift172 gene Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Taurus_UMD|evm.model.AC_000168.1.552 Q3SZ72 KCP3_BOVIN 99.583 0.991701 1.00417 KRTCAP3 - Keratinocyte-associated protein 3 - Bos taurus (Bovine) - KRTCAP3 gene Taurus_UMD|evm.model.AC_000168.1.553 Q4R8X0 NRBP_MACFA 99.626 0.735537 1.35701 NRBP1 - Nuclear receptor-binding protein - Macaca fascicularis (Crab-eating macaque) - NRBP1 gene May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Taurus_UMD|evm.model.AC_000168.1.554 P79126 PPM1G_BOVIN 100.000 0.996101 0.944751 PPM1G - Protein phosphatase 1G - Bos taurus (Bovine) - PPM1G gene nucleoplasm, protein serine/threonine phosphatase activity, protein dephosphorylation Taurus_UMD|evm.model.AC_000168.1.555 Q8N8E2 ZN513_HUMAN 96.494 0.994475 1.0037 ZNF513 - Zinc finger protein 513 - Homo sapiens (Human) - ZNF513 gene Transcriptional regulator that plays a role in retinal development and maintenance. Taurus_UMD|evm.model.AC_000168.1.556 Q5EA77 SNX17_BOVIN 100.000 0.995754 1.00213 SNX17 - Sorting nexin-17 - Bos taurus (Bovine) - SNX17 gene Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). Taurus_UMD|evm.model.AC_000168.1.557 Q3T058 EI2BD_BOVIN 99.618 0.99619 1.00191 EIF2B4 - Translation initiation factor eIF-2B subunit delta - Bos taurus (Bovine) - EIF2B4 gene Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Taurus_UMD|evm.model.AC_000168.1.558 Q5RDC3 TF3C2_PONAB 89.791 0.997802 0.998902 GTF3C2 - General transcription factor 3C polypeptide 2 - Pongo abelii (Sumatran orangutan) - GTF3C2 gene Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1 (By similarity). Taurus_UMD|evm.model.AC_000168.1.559 Q2KIN6 MPV17_BOVIN 100.000 0.988701 1.00568 MPV17 - Protein Mpv17 - Bos taurus (Bovine) - MPV17 gene Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis. Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (By similarity). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity). Taurus_UMD|evm.model.AC_000168.1.560 P55089 UCN1_HUMAN 84.496 0.984615 1.04839 UCN - Urocortin precursor - Homo sapiens (Human) - UCN gene Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity). Taurus_UMD|evm.model.AC_000168.1.561 Q58D15 TRI54_BOVIN 100.000 0.99455 1.00273 TRIM54 - Tripartite motif-containing protein 54 - Bos taurus (Bovine) - TRIM54 gene May bind and stabilize microtubules during myotubes formation. Taurus_UMD|evm.model.AC_000168.1.562 Q8N7S2 DNJ5G_HUMAN 68.783 0.982857 0.925926 DNAJC5G - DnaJ homolog subfamily C member 5G - Homo sapiens (Human) - DNAJC5G gene Taurus_UMD|evm.model.AC_000168.1.563 Q08E25 ZNT3_BOVIN 100.000 0.994859 1.00258 SLC30A3 - Zinc transporter 3 - Bos taurus (Bovine) - SLC30A3 gene Involved in accumulation of zinc in synaptic vesicles. Taurus_UMD|evm.model.AC_000168.1.564 P27708 PYR1_HUMAN 95.959 0.999102 1.00045 CAD - CAD protein - Homo sapiens (Human) - CAD gene This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). Taurus_UMD|evm.model.AC_000168.1.566 Q9XT77 SC5A6_RABIT 88.245 0.99687 1.00472 SLC5A6 - Sodium-dependent multivitamin transporter - Oryctolagus cuniculus (Rabbit) - SLC5A6 gene Sodium-dependent multivitamin transporter that transports pantothenate, biotin and lipoate (By similarity). Required for biotin and pantothenate uptake in the instestine (By similarity). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). May play a role in the transport of biotin and pantothenate into the brain across the blood-brain barrier (By similarity). May also be involved in the sodium-dependent transport of iodide ions (By similarity). Taurus_UMD|evm.model.AC_000168.1.567 Q2T9Q7 TCF23_BOVIN 99.507 0.990196 0.953271 TCF23 - Transcription factor 23 - Bos taurus (Bovine) - TCF23 gene Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity). Taurus_UMD|evm.model.AC_000168.1.568 Q53SZ7 PRR30_HUMAN 65.122 0.989975 0.968447 PRR30 - Proline-rich protein 30 - Homo sapiens (Human) - PRR30 gene Taurus_UMD|evm.model.AC_000168.1.569 Q9HCU5 PREB_HUMAN 92.584 0.995227 1.0048 PREB - Prolactin regulatory element-binding protein - Homo sapiens (Human) - PREB gene Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. Taurus_UMD|evm.model.AC_000168.1.570 Q3T0A0 ABHD1_BOVIN 100.000 0.995062 1.00248 ABHD1 - Protein ABHD1 - Bos taurus (Bovine) - ABHD1 gene acetylesterase activity, acylglycerol lipase activity, short-chain carboxylesterase activity, cellular lipid metabolic process, medium-chain fatty acid biosynthetic process, medium-chain fatty acid catabolic process Taurus_UMD|evm.model.AC_000168.1.571 Q8R1U2 CGRE1_MOUSE 60.985 0.792208 1.09609 Cgref1 - Cell growth regulator with EF hand domain protein 1 precursor - Mus musculus (Mouse) - Cgref1 gene Mediates cell-cell adhesion in a calcium-dependent manner. Able to inhibit growth in several cell lines (By similarity). Taurus_UMD|evm.model.AC_000168.1.572 Q02974 KHK_RAT 76.385 0.994012 1.12081 Khk - Ketohexokinase - Rattus norvegicus (Rat) - Khk gene Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. Taurus_UMD|evm.model.AC_000168.1.573 Q9Y6C2 EMIL1_HUMAN 89.980 0.998031 1 EMILIN1 - EMILIN-1 precursor - Homo sapiens (Human) - EMILIN1 gene May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity. Taurus_UMD|evm.model.AC_000168.1.574 B0BLS0 OST4_RAT 100.000 0.5 1.94595 Ost4 - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 - Rattus norvegicus (Rat) - Ost4 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes. Taurus_UMD|evm.model.AC_000168.1.575 Q58CX9 CBPC5_BOVIN 100.000 0.997743 1.00113 AGBL5 - Cytosolic carboxypeptidase-like protein 5 - Bos taurus (Bovine) - AGBL5 gene Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Taurus_UMD|evm.model.AC_000168.1.576 A4FV45 TM214_BOVIN 100.000 0.997093 1.00146 TMEM214 - Transmembrane protein 214 - Bos taurus (Bovine) - TMEM214 gene Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress (By similarity). Taurus_UMD|evm.model.AC_000168.1.577 Q9UPY8 MARE3_HUMAN 99.644 0.968858 1.02847 MAPRE3 - Microtubule-associated protein RP/EB family member 3 - Homo sapiens (Human) - MAPRE3 gene Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). May play a role in cell migration (By similarity). Taurus_UMD|evm.model.AC_000168.1.578 Q9BPU6 DPYL5_HUMAN 98.936 0.99646 1.00177 DPYSL5 - Dihydropyrimidinase-related protein 5 - Homo sapiens (Human) - DPYSL5 gene May have a function in neuronal differentiation and/or axon growth. Taurus_UMD|evm.model.AC_000168.1.579 P49449 CENPA_BOVIN 99.275 0.985612 1.00725 CENPA - Histone H3-like centromeric protein A - Bos taurus (Bovine) - CENPA gene Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis. Taurus_UMD|evm.model.AC_000168.1.580 Q5RFT1 S35F6_PONAB 94.340 0.994624 1.0027 SLC35F6 - Solute carrier family 35 member F6 precursor - Pongo abelii (Sumatran orangutan) - SLC35F6 gene Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (By similarity). Taurus_UMD|evm.model.AC_000168.1.581 O14649 KCNK3_HUMAN 95.771 0.995037 1.02284 KCNK3 - Potassium channel subfamily K member 3 - Homo sapiens (Human) - KCNK3 gene pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Taurus_UMD|evm.model.AC_000168.1.583 C7A278 CIB4_SHEEP 100.000 0.989247 1.00541 CIB4 - Calcium and integrin-binding family member 4 - Ovis aries (Sheep) - CIB4 gene calcium ion binding, magnesium ion binding Taurus_UMD|evm.model.AC_000168.1.584 Q3SZR5 F166C_BOVIN 100.000 0.990099 1.00498 FAM166C - Protein FAM166C - Bos taurus (Bovine) - FAM166C gene Taurus_UMD|evm.model.AC_000168.1.586 Q9HC10 OTOF_HUMAN 94.294 0.998999 1.001 OTOF - Otoferlin - Homo sapiens (Human) - OTOF gene Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity). Taurus_UMD|evm.model.AC_000168.1.587 Q32KY1 DRC1_BOVIN 100.000 0.997195 1.0014 DRC1 - Dynein regulatory complex protein 1 - Bos taurus (Bovine) - DRC1 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Taurus_UMD|evm.model.AC_000168.1.588 Q17QM4 EPT1_BOVIN 100.000 0.994832 0.974811 SELENOI - Ethanolaminephosphotransferase 1 - Bos taurus (Bovine) - SELENOI gene Ethanolaminephosphotransferase that catalyzes the transfer of phosphoethanolamine/PE from CDP-ethanolamine to lipid acceptors, the final step in the synthesis of PE via the 'Kennedy' pathway. PE is the second most abundant phospholipid of membranes in mammals and is involved in various membrane-related cellular processes. The enzyme is critical for the synthesis of several PE species and could also catalyze the synthesis of ether-linked phospholipids like plasmanyl- and plasmenyl-PE which could explain it is required for proper myelination and neurodevelopment. Taurus_UMD|evm.model.AC_000168.1.589 Q8IZF5 AGRF3_HUMAN 73.109 0.86864 1.00185 ADGRF3 - Adhesion G-protein coupled receptor F3 precursor - Homo sapiens (Human) - ADGRF3 gene Orphan receptor. Taurus_UMD|evm.model.AC_000168.1.590 O46629 ECHB_BOVIN 100.000 0.983402 1.01474 HADHB - Trifunctional enzyme subunit beta, mitochondrial precursor - Bos taurus (Bovine) - HADHB gene Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity. Taurus_UMD|evm.model.AC_000168.1.591 Q29554 ECHA_PIG 90.301 0.997382 1.00131 HADHA - Trifunctional enzyme subunit alpha, mitochondrial precursor - Sus scrofa (Pig) - HADHA gene Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity. Independently of the subunit beta, the trifunctional enzyme subunit alpha/HADHA also has a monolysocardiolipin acyltransferase activity. It acylates monolysocardiolipin into cardiolipin, a major mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes in the generation of ATP. Allows the acylation of monolysocardiolipin with different acyl-CoA substrates including oleoyl-CoA for which it displays the highest activity. Taurus_UMD|evm.model.AC_000168.1.592 Q75VX8 GARE2_HUMAN 88.558 0.915254 0.540046 GAREM2 - GRB2-associated and regulator of MAPK protein 2 - Homo sapiens (Human) - GAREM2 gene Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. Taurus_UMD|evm.model.AC_000168.1.593 Q6PAJ3 GARE2_MOUSE 95.789 0.895238 0.119318 Garem2 - GRB2-associated and regulator of MAPK protein 2 - Mus musculus (Mouse) - Garem2 gene Probable adapter protein that provides a critical link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. Taurus_UMD|evm.model.AC_000168.1.594 Q6PAJ3 GARE2_MOUSE 88.757 0.820513 0.221591 Garem2 - GRB2-associated and regulator of MAPK protein 2 - Mus musculus (Mouse) - Garem2 gene Probable adapter protein that provides a critical link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. Taurus_UMD|evm.model.AC_000168.1.595 Q5R5U1 RAB10_PONAB 100.000 0.99005 1.005 RAB10 - Ras-related protein Rab-10 - Pongo abelii (Sumatran orangutan) - RAB10 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Plays also a specific role in asymmetric protein transport to the plasma membranes (By similarity). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane. In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (By similarity). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (By similarity). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (By similarity). When phosphorylated by LRRK2 on Thr-73, it binds RILPL1 and inhibits ciliogenesis (By similarity). Taurus_UMD|evm.model.AC_000168.1.596 A0JN40 KIF3C_BOVIN 95.707 0.997365 0.958333 KIF3C - Kinesin-like protein KIF3C - Bos taurus (Bovine) - KIF3C gene Microtubule-based anterograde translocator for membranous organelles. Taurus_UMD|evm.model.AC_000168.1.597 Q90YQ8 RS15A_ICTPU 92.105 0.889764 0.976923 rps15a - 40S ribosomal protein S15a - Ictalurus punctatus (Channel catfish) - rps15a gene Structural component of the ribosome. Taurus_UMD|evm.model.AC_000168.1.598 O60941 DTNB_HUMAN 98.263 0.250727 3.28868 DTNB - Dystrobrevin beta - Homo sapiens (Human) - DTNB gene Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). Taurus_UMD|evm.model.AC_000168.1.599 Q1LZ53 DNM3A_RAT 96.887 0.95297 0.889868 Dnmt3a - DNA (cytosine-5)-methyltransferase 3A - Rattus norvegicus (Rat) - Dnmt3a gene Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-706 in absence of DNA (By similarity). Taurus_UMD|evm.model.AC_000168.1.601 P01190 COLI_BOVIN 100.000 0.992481 1.00377 POMC - Pro-opiomelanocortin precursor - Bos taurus (Bovine) - POMC gene Stimulates the adrenal glands to release cortisol. Taurus_UMD|evm.model.AC_000168.1.602 Q9Y2G0 EFR3B_HUMAN 97.430 0.997555 1.00122 EFR3B - Protein EFR3 homolog B - Homo sapiens (Human) - EFR3B gene Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). Taurus_UMD|evm.model.AC_000168.1.603 A5D7F5 DJC27_BOVIN 100.000 0.992701 1.00366 DNAJC27 - DnaJ homolog subfamily C member 27 - Bos taurus (Bovine) - DNAJC27 gene GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. Taurus_UMD|evm.model.AC_000168.1.604 O60266 ADCY3_HUMAN 94.672 0.998255 1.00175 ADCY3 - Adenylate cyclase type 3 - Homo sapiens (Human) - ADCY3 gene Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. Taurus_UMD|evm.model.AC_000168.1.605 Q3ZBK8 CENPO_BOVIN 100.000 0.993266 1.00338 CENPO - Centromere protein O - Bos taurus (Bovine) - CENPO gene Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex (By similarity). Taurus_UMD|evm.model.AC_000168.1.606 Q3SZ85 PTRD1_BOVIN 100.000 0.985816 1.00714 PTRHD1 - Putative peptidyl-tRNA hydrolase PTRHD1 - Bos taurus (Bovine) - PTRHD1 gene Taurus_UMD|evm.model.AC_000168.1.607 Q4PJW2 NCOA1_PIG 96.877 0.998613 1.00139 NCOA1 - Nuclear receptor coactivator 1 - Sus scrofa (Pig) - NCOA1 gene Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response (By similarity). Taurus_UMD|evm.model.AC_000168.1.609 Q9NZM3 ITSN2_HUMAN 91.343 0.998791 0.974661 ITSN2 - Intersectin-2 - Homo sapiens (Human) - ITSN2 gene Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Taurus_UMD|evm.model.AC_000168.1.610 Q32KQ1 F228A_BOVIN 100.000 0.481032 2.07233 FAM228A - Protein FAM228A - Bos taurus (Bovine) - FAM228A gene Taurus_UMD|evm.model.AC_000168.1.611 Q2NKT1 PROF4_BOVIN 100.000 0.984615 1.00775 PFN4 - Profilin-4 - Bos taurus (Bovine) - PFN4 gene Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Taurus_UMD|evm.model.AC_000168.1.612 Q53FA7 QORX_HUMAN 88.855 0.993994 1.00301 TP53I3 - Quinone oxidoreductase PIG3 - Homo sapiens (Human) - TP53I3 gene May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro). Taurus_UMD|evm.model.AC_000168.1.613 P59708 SF3B6_MOUSE 100.000 0.984127 1.008 Sf3b6 - Splicing factor 3B subunit 6 - Mus musculus (Mouse) - Sf3b6 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively. Taurus_UMD|evm.model.AC_000168.1.614 P68106 FKB1B_HUMAN 100.000 0.981651 1.00926 FKBP1B - Peptidyl-prolyl cis-trans isomerase FKBP1B - Homo sapiens (Human) - FKBP1B gene Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Taurus_UMD|evm.model.AC_000168.1.615 Q9H6R7 WDCP_HUMAN 73.517 0.965567 0.966713 WDCP - WD repeat and coiled-coil-containing protein - Homo sapiens (Human) - WDCP gene kinase binding, protein complex oligomerization Taurus_UMD|evm.model.AC_000168.1.616 A6NFX1 MFS2B_HUMAN 84.355 0.94 0.992063 MFSD2B - Major facilitator superfamily domain-containing protein 2B - Homo sapiens (Human) - MFSD2B gene Cation-dependent lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets (PubMed:29045386). Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Does not transport lysophosphatidylcholine (LPC) (By similarity). Taurus_UMD|evm.model.AC_000168.1.617 P68543 UBX2A_HUMAN 90.310 0.992278 1 UBXN2A - UBX domain-containing protein 2A - Homo sapiens (Human) - UBXN2A gene cytosol, nucleus, ubiquitin binding, autophagosome assembly, Golgi organization, membrane fusion, nuclear envelope reassembly, proteasome-mediated ubiquitin-dependent protein catabolic process Taurus_UMD|evm.model.AC_000168.1.618 Q9ULI0 ATD2B_HUMAN 96.982 0.998629 1.00069 ATAD2B - ATPase family AAA domain-containing protein 2B - Homo sapiens (Human) - ATAD2B gene nucleoplasm, nucleus, ATPase activity, chromatin binding, histone binding, lysine-acetylated histone binding, negative regulation of chromatin silencing, positive regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000168.1.619 Q96CT2 KLH29_HUMAN 96.457 0.997717 1.00114 KLHL29 - Kelch-like protein 29 - Homo sapiens (Human) - KLHL29 gene Taurus_UMD|evm.model.AC_000168.1.625 Q5E983 EF1B_BOVIN 93.377 0.980392 0.68 EEF1B - Elongation factor 1-beta - Bos taurus (Bovine) - EEF1B gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Taurus_UMD|evm.model.AC_000168.1.626 P62268 RS23_RAT 95.105 0.934211 1.06294 Rps23 - 40S ribosomal protein S23 - Rattus norvegicus (Rat) - Rps23 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy. Taurus_UMD|evm.model.AC_000168.1.627 B5MCY1 TDR15_HUMAN 76.983 0.326569 0.815408 TDRD15 - Tudor domain-containing protein 15 - Homo sapiens (Human) - TDRD15 gene Taurus_UMD|evm.model.AC_000168.1.628 P17165 APOB_RABIT 80.556 0.0325074 30.5486 APOB - Apolipoprotein B - Oryctolagus cuniculus (Rabbit) - APOB gene Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Taurus_UMD|evm.model.AC_000168.1.630 Q9H6V9 LDAH_HUMAN 78.769 0.993865 1.00308 LDAH - Lipid droplet-associated hydrolase - Homo sapiens (Human) - LDAH gene Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages. Taurus_UMD|evm.model.AC_000168.1.631 Q9BDW8 GDF7_CHLAE 82.069 0.655068 1.47875 GDF7 - Growth/differentiation factor 7 precursor - Chlorocebus aethiops (Green monkey) - GDF7 gene May play an active role in the motor area of the primate neocortex. Taurus_UMD|evm.model.AC_000168.1.633 Q53T59 H1BP3_HUMAN 77.041 0.98731 1.0051 HS1BP3 - HCLS1-binding protein 3 - Homo sapiens (Human) - HS1BP3 gene May be a modulator of IL-2 signaling. Taurus_UMD|evm.model.AC_000168.1.634 P62747 RHOB_RAT 100.000 0.989848 1.0051 Rhob - Rho-related GTP-binding protein RhoB precursor - Rattus norvegicus (Rat) - Rhob gene Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells (By similarity). Taurus_UMD|evm.model.AC_000168.1.635 P82252 BAT1_RAT 36.032 0.986333 0.901437 Slc7a9 - b(0,+)-type amino acid transporter 1 - Rattus norvegicus (Rat) - Slc7a9 gene Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney proximal tubule. Taurus_UMD|evm.model.AC_000168.1.636 Q80U58 PUM2_MOUSE 96.127 0.573604 0.924015 Pum2 - Pumilio homolog 2 - Mus musculus (Mouse) - Pum2 gene Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation. Plays a role in cytoplasmic sensing of viral infection. Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm. May regulate DCUN1D3 mRNA levels. May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (By similarity). Taurus_UMD|evm.model.AC_000168.1.637 Q08DZ5 SDC1_BOVIN 100.000 0.99359 1.00322 SDC1 - Syndecan-1 precursor - Bos taurus (Bovine) - SDC1 gene Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Taurus_UMD|evm.model.AC_000168.1.638 Q6QRN8 LAP4A_BOVIN 100.000 0.991453 1.00429 LAPTM4A - Lysosomal-associated transmembrane protein 4A - Bos taurus (Bovine) - LAPTM4A gene May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. Taurus_UMD|evm.model.AC_000168.1.639 A6N6J5 WDR35_RAT 89.126 0.617368 1.25983 Wdr35 - WD repeat-containing protein 35 - Rattus norvegicus (Rat) - Wdr35 gene As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking (By similarity). May promote CASP3 activation and TNF-stimulated apoptosis (PubMed:20193664). Taurus_UMD|evm.model.AC_000168.1.640 Q5I0X7 TTC32_HUMAN 87.755 0.979866 0.986755 TTC32 - Tetratricopeptide repeat protein 32 - Homo sapiens (Human) - TTC32 gene Taurus_UMD|evm.model.AC_000168.1.643 Q08DS3 OSR1_BOVIN 100.000 0.992537 1.00375 OSR1 - Protein odd-skipped-related 1 - Bos taurus (Bovine) - OSR1 gene Transcription factor that plays a role in the regulation of embryonic heart and urogenital development. Taurus_UMD|evm.model.AC_000168.1.645 Q32L59 TMC5B_BOVIN 93.750 0.0919881 0.960114 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Taurus_UMD|evm.model.AC_000168.1.646 P08548 LIN1_NYCCO 26.934 0.655446 0.400794 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Taurus_UMD|evm.model.AC_000168.1.648 Q96P26 5NT1B_HUMAN 69.288 0.925664 0.92623 NT5C1B - Cytosolic 5'-nucleotidase 1B - Homo sapiens (Human) - NT5C1B gene Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity). Taurus_UMD|evm.model.AC_000168.1.649 Q17QW3 RDH14_BOVIN 100.000 0.994065 1.00298 RDH14 - Retinol dehydrogenase 14 - Bos taurus (Bovine) - RDH14 gene Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol. Shows a very weak activity towards 13-cis-retinol. Has no activity towards steroid. Taurus_UMD|evm.model.AC_000168.1.650 Q9TT17 KCNS3_RABIT 96.516 0.989837 1.00204 KCNS3 - Potassium voltage-gated channel subfamily S member 3 - Oryctolagus cuniculus (Rabbit) - KCNS3 gene Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells. Taurus_UMD|evm.model.AC_000168.1.651 A6NI15 MSGN1_HUMAN 87.565 0.989691 1.00518 MSGN1 - Mesogenin-1 - Homo sapiens (Human) - MSGN1 gene Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity). Taurus_UMD|evm.model.AC_000168.1.652 Q17RS7 GEN_HUMAN 75.679 0.997625 0.927313 GEN1 - Flap endonuclease GEN homolog 1 - Homo sapiens (Human) - GEN1 gene Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation (PubMed:19020614, PubMed:26682650). Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid. Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction (PubMed:26578604). Efficiently cleaves both single and double HJs contained within large recombination intermediates. Exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA (PubMed:28049850). Has also endonuclease activity on 5'-flap and replication fork (RF) DNA substrates (PubMed:26578604). Taurus_UMD|evm.model.AC_000168.1.653 Q96SB8 SMC6_HUMAN 91.431 0.99727 1.00733 SMC6 - Structural maintenance of chromosomes protein 6 - Homo sapiens (Human) - SMC6 gene Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). Taurus_UMD|evm.model.AC_000168.1.654 P62762 VISL1_RAT 100.000 0.818966 1.21466 Vsnl1 - Visinin-like protein 1 - Rattus norvegicus (Rat) - Vsnl1 gene Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. Taurus_UMD|evm.model.AC_000168.1.655 Q09MP3 R51A2_HUMAN 64.122 0.35576 0.936152 RAD51AP2 - RAD51-associated protein 2 - Homo sapiens (Human) - RAD51AP2 gene protein-containing complex, double-stranded DNA binding, single-stranded DNA binding, double-strand break repair via homologous recombination, interstrand cross-link repair Taurus_UMD|evm.model.AC_000168.1.656 Q5R6L2 CYRIA_PONAB 100.000 0.993827 1.0031 CYRIA - CYFIP-related Rac1 interactor A - Pongo abelii (Sumatran orangutan) - CYRIA gene May negatively regulate RAC1 signaling and RAC1-driven cytoskeletal remodeling. May regulate chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Taurus_UMD|evm.model.AC_000168.1.658 P04198 MYCN_HUMAN 93.833 0.821818 0.592672 MYCN - N-myc proto-oncogene protein - Homo sapiens (Human) - MYCN gene Positively regulates the transcription of MYCNOS in neuroblastoma cells. Taurus_UMD|evm.model.AC_000168.1.660 Q0IIK5 DDX1_BOVIN 100.000 0.997301 1.00135 DDX1 - ATP-dependent RNA helicase DDX1 - Bos taurus (Bovine) - DDX1 gene Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). Taurus_UMD|evm.model.AC_000168.1.661 A2RRP1 NBAS_HUMAN 93.462 0.354765 0.924926 NBAS - Neuroblastoma-amplified sequence - Homo sapiens (Human) - NBAS gene Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). Taurus_UMD|evm.model.AC_000168.1.662 Q3ZCA1 LRAT1_BOVIN 100.000 0.993289 1.00337 LRATD1 - Protein LRATD1 - Bos taurus (Bovine) - LRATD1 gene May play a role in cell morphology and motility. Taurus_UMD|evm.model.AC_000168.1.663 P61203 CSN2_RAT 98.444 0.995565 1.01806 Cops2 - COP9 signalosome complex subunit 2 - Rattus norvegicus (Rat) - Cops2 gene Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. Taurus_UMD|evm.model.AC_000168.1.664 Q13309 SKP2_HUMAN 73.375 0.98917 0.653302 SKP2 - S-phase kinase-associated protein 2 - Homo sapiens (Human) - SKP2 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:17962192, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Taurus_UMD|evm.model.AC_000168.1.666 Q5GLH2 TRIB2_BOVIN 100.000 0.994186 1.00292 TRIB2 - Tribbles homolog 2 - Bos taurus (Bovine) - TRIB2 gene Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). Taurus_UMD|evm.model.AC_000168.1.667 Q91ZP3 LPIN1_MOUSE 84.872 0.915897 1.05519 Lpin1 - Phosphatidate phosphatase LPIN1 - Mus musculus (Mouse) - Lpin1 gene Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels (PubMed:17158099). Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol. Taurus_UMD|evm.model.AC_000168.1.668 O95665 NTR2_HUMAN 80.153 0.941176 0.995122 NTSR2 - Neurotensin receptor type 2 - Homo sapiens (Human) - NTSR2 gene Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000168.1.669 Q4ZG55 GREB1_HUMAN 90.830 0.969062 1.02822 GREB1 - Protein GREB1 - Homo sapiens (Human) - GREB1 gene May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers. Taurus_UMD|evm.model.AC_000168.1.670 Q08DY6 E2F6_BOVIN 98.264 0.99308 1.01404 E2F6 - Transcription factor E2F6 - Bos taurus (Bovine) - E2F6 gene Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains (By similarity). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (By similarity). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (By similarity). Taurus_UMD|evm.model.AC_000168.1.671 Q28021 ROCK2_BOVIN 99.851 0.977389 0.987752 ROCK2 - Rho-associated protein kinase 2 - Bos taurus (Bovine) - ROCK2 gene Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. Taurus_UMD|evm.model.AC_000168.1.672 Q8N755 S66A3_HUMAN 81.313 0.975248 1 SLC66A3 - Solute carrier family 66 member 3 precursor - Homo sapiens (Human) - SLC66A3 gene Taurus_UMD|evm.model.AC_000168.1.673 Q1JPL0 CB050_BOVIN 100.000 0.987342 1.00637 Uncharacterized protein C2orf50 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000168.1.674 Q9H3M0 KCNF1_HUMAN 96.364 0.995968 1.00405 KCNF1 - Potassium voltage-gated channel subfamily F member 1 - Homo sapiens (Human) - KCNF1 gene Putative voltage-gated potassium channel. Taurus_UMD|evm.model.AC_000168.1.675 Q922R8 PDIA6_MOUSE 95.909 0.995465 1.00227 Pdia6 - Protein disulfide-isomerase A6 precursor - Mus musculus (Mouse) - Pdia6 gene May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:24508390). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (By similarity). May also regulate the UPR via the EIF2AK3 UPR sensor (By similarity). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (By similarity). Taurus_UMD|evm.model.AC_000168.1.676 Q8NEY4 VATC2_HUMAN 94.145 0.995327 1.00234 ATP6V1C2 - V-type proton ATPase subunit C 2 - Homo sapiens (Human) - ATP6V1C2 gene Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Taurus_UMD|evm.model.AC_000168.1.677 Q9BSC4 NOL10_HUMAN 90.262 0.99689 0.934593 NOL10 - Nucleolar protein 10 - Homo sapiens (Human) - NOL10 gene nucleolus, small-subunit processome, RNA binding, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000168.1.678 P27117 DCOR_BOVIN 100.000 0.995671 1.00217 ODC1 - Ornithine decarboxylase - Bos taurus (Bovine) - ODC1 gene Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Taurus_UMD|evm.model.AC_000168.1.679 B3VSB7 HPCL1_SHEEP 100.000 0.989691 1.00518 HPCAL1 - Hippocalcin-like protein 1 - Ovis aries (Sheep) - HPCAL1 gene May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Taurus_UMD|evm.model.AC_000168.1.682 P31350 RIR2_HUMAN 94.859 0.994872 1.00257 RRM2 - Ribonucleoside-diphosphate reductase subunit M2 - Homo sapiens (Human) - RRM2 gene Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Taurus_UMD|evm.model.AC_000168.1.683 Q8R4T1 CYS1_MOUSE 70.588 0.337838 1.02069 Cys1 - Cystin-1 - Mus musculus (Mouse) - Cys1 gene axoneme, ciliary basal body, cytosol, membrane, nucleus, chromatin binding, transcription corepressor activity, inner ear development, kidney development, negative regulation of DNA-binding transcription factor activity Taurus_UMD|evm.model.AC_000168.1.684 Q9JJZ6 KLF13_MOUSE 77.907 0.162214 1.81315 Klf13 - Krueppel-like factor 13 - Mus musculus (Mouse) - Klf13 gene Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage. Taurus_UMD|evm.model.AC_000168.1.685 Q5RAR8 GRHL1_PONAB 91.746 0.74673 1.36084 GRHL1 - Grainyhead-like protein 1 homolog - Pongo abelii (Sumatran orangutan) - GRHL1 gene Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Taurus_UMD|evm.model.AC_000168.1.686 Q1JQD6 TAF1B_BOVIN 87.458 0.996248 0.90339 TAF1B - TATA box-binding protein-associated factor RNA polymerase I subunit B - Bos taurus (Bovine) - TAF1B gene Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3 (By similarity). Taurus_UMD|evm.model.AC_000168.1.687 Q5RFJ2 1433T_PONAB 100.000 0.99187 1.00408 YWHAQ - 14-3-3 protein theta - Pongo abelii (Sumatran orangutan) - YWHAQ gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). Taurus_UMD|evm.model.AC_000168.1.688 O77636 ADA17_PIG 99.107 0.134383 7.375 ADAM17 - Disintegrin and metalloproteinase domain-containing protein 17 - Sus scrofa (Pig) - ADAM17 gene Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (By similarity). Taurus_UMD|evm.model.AC_000168.1.689 Q3SZ16 IAH1_BOVIN 100.000 0.992 1.00402 IAH1 - Isoamyl acetate-hydrolyzing esterase 1 homolog - Bos taurus (Bovine) - IAH1 gene Probable lipase. Taurus_UMD|evm.model.AC_000168.1.690 P79101 CPSF3_BOVIN 100.000 0.99708 1.00146 CPSF3 - Cleavage and polyadenylation specificity factor subunit 3 - Bos taurus (Bovine) - CPSF3 gene Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Taurus_UMD|evm.model.AC_000168.1.691 Q3ZBM4 ITBP1_BOVIN 100.000 0.99005 1.005 ITGB1BP1 - Integrin beta-1-binding protein 1 - Bos taurus (Bovine) - ITGB1BP1 gene Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter (By similarity). Taurus_UMD|evm.model.AC_000168.1.692 Q7SIG6 ASAP2_MOUSE 82.898 0.997669 0.895616 Asap2 - Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 - Mus musculus (Mouse) - Asap2 gene Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration (By similarity). Taurus_UMD|evm.model.AC_000168.1.693 Q6ZWT7 MBOA2_HUMAN 85.253 0.995745 0.903846 MBOAT2 - Lysophospholipid acyltransferase 2 - Homo sapiens (Human) - MBOAT2 gene Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Catalyzes preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS) (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor (PubMed:18772128). May be involved in chondrocyte differentiation (By similarity). Taurus_UMD|evm.model.AC_000168.1.694 Q9ULH0 KDIS_HUMAN 94.706 0.985476 0.777527 KIDINS220 - Kinase D-interacting substrate of 220 kDa - Homo sapiens (Human) - KIDINS220 gene Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. Taurus_UMD|evm.model.AC_000168.1.696 Q3ZC46 ID2_BOVIN 100.000 0.985185 1.00746 ID2 - DNA-binding protein inhibitor ID-2 - Bos taurus (Bovine) - ID2 gene Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism (By similarity). Taurus_UMD|evm.model.AC_000168.1.697 Q4R7Y2 RL10_MACFA 61.364 0.460317 0.883178 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000168.1.699 Q99877 H2B1N_HUMAN 91.379 0.92 0.992063 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000168.1.700 Q9NR30 DDX21_HUMAN 82.456 0.302703 0.236271 DDX21 - Nucleolar RNA helicase 2 - Homo sapiens (Human) - DDX21 gene RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Taurus_UMD|evm.model.AC_000168.1.704 Q925F3 R144A_MOUSE 94.198 0.993197 1.00685 Rnf144a - E3 ubiquitin-protein ligase RNF144A - Mus musculus (Mouse) - Rnf144a gene E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC. Taurus_UMD|evm.model.AC_000168.1.705 Q2HJF9 RSAD2_BOVIN 100.000 0.994505 1.00275 RSAD2 - Radical S-adenosyl methionine domain-containing protein 2 - Bos taurus (Bovine) - RSAD2 gene Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyszes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses. Promotes also TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins. Taurus_UMD|evm.model.AC_000168.1.706 Q5EBM0 CMPK2_HUMAN 79.233 0.748276 1.29176 CMPK2 - UMP-CMP kinase 2, mitochondrial precursor - Homo sapiens (Human) - CMPK2 gene May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. Taurus_UMD|evm.model.AC_000168.1.709 P35716 SOX11_HUMAN 71.134 0.6787 0.628118 SOX11 - Transcription factor SOX-11 - Homo sapiens (Human) - SOX11 gene Transcription factor that acts as a transcriptional activator (PubMed:24886874). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity). Taurus_UMD|evm.model.AC_000168.1.711 Q9UNH6 SNX7_HUMAN 86.364 0.970149 0.346253 SNX7 - Sorting nexin-7 - Homo sapiens (Human) - SNX7 gene May be involved in several stages of intracellular trafficking. Taurus_UMD|evm.model.AC_000168.1.712 Q9UNH6 SNX7_HUMAN 92.174 0.982759 0.299742 SNX7 - Sorting nexin-7 - Homo sapiens (Human) - SNX7 gene May be involved in several stages of intracellular trafficking. Taurus_UMD|evm.model.AC_000168.1.717 G3V9Q9 GTA1L_RAT 64.214 0.916149 1.00312 Ggta1l1 - N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1 - Rattus norvegicus (Rat) - Ggta1l1 gene Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Taurus_UMD|evm.model.AC_000168.1.718 Q8HYB2 GGTA1_LEMCA 66.667 0.862275 0.890667 GGTA1 - N-acetyllactosaminide alpha-1,3-galactosyltransferase - Lemur catta (Ring-tailed lemur) - GGTA1 gene Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isogloboside 3 (iGb3) (By similarity). Taurus_UMD|evm.model.AC_000168.1.719 P14769 GGTA1_BOVIN 100.000 0.99458 1.00272 GGTA1 - N-acetyllactosaminide alpha-1,3-galactosyltransferase - Bos taurus (Bovine) - GGTA1 gene Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isoglobotrihexosylceramide or isogloboside 3 (iGb3). Taurus_UMD|evm.model.AC_000168.1.722 Q6P730 DAB2P_RAT 97.110 0.847636 1.14659 Dab2ip - Disabled homolog 2-interacting protein - Rattus norvegicus (Rat) - Dab2ip gene Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively (By similarity). Mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Functions as a Ras GTPase-activating protein. May act as a tumor suppressor gene. Taurus_UMD|evm.model.AC_000168.1.723 Q8NHH1 TTL11_HUMAN 86.016 0.978827 0.7675 TTLL11 - Tubulin polyglutamylase TTLL11 - Homo sapiens (Human) - TTLL11 gene Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Generates long side-chains (By similarity). Taurus_UMD|evm.model.AC_000168.1.724 P42029 NDUA8_BOVIN 100.000 0.988439 1.00581 NDUFA8 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 - Bos taurus (Bovine) - NDUFA8 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000168.1.725 Q32LL6 MORN5_BOVIN 100.000 0.988439 1.00581 MORN5 - MORN repeat-containing protein 5 - Bos taurus (Bovine) - MORN5 gene Taurus_UMD|evm.model.AC_000168.1.726 Q9UPM6 LHX6_HUMAN 98.898 0.707031 1.41047 LHX6 - LIM/homeobox protein Lhx6 - Homo sapiens (Human) - LHX6 gene Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity). Taurus_UMD|evm.model.AC_000168.1.727 Q3ZCC5 RBM18_BOVIN 100.000 0.989529 1.00526 RBM18 - Probable RNA-binding protein 18 - Bos taurus (Bovine) - RBM18 gene RNA binding Taurus_UMD|evm.model.AC_000168.1.728 Q0VCQ4 RRFM_BOVIN 96.855 0.542955 1.11069 MRRF - Ribosome-recycling factor, mitochondrial precursor - Bos taurus (Bovine) - MRRF gene Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity). Taurus_UMD|evm.model.AC_000168.1.729 Q9D6S7 RRFM_MOUSE 88.696 0.857143 0.507634 Mrrf - Ribosome-recycling factor, mitochondrial precursor - Mus musculus (Mouse) - Mrrf gene Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity). Taurus_UMD|evm.model.AC_000168.1.730 O62664 PGH1_BOVIN 100.000 0.996672 1.00167 PTGS1 - Prostaglandin G/H synthase 1 precursor - Bos taurus (Bovine) - PTGS1 gene Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. Taurus_UMD|evm.model.AC_000168.1.731 Q6ZRY4 RBPS2_HUMAN 82.418 0.592105 0.727273 RBPMS2 - RNA-binding protein with multiple splicing 2 - Homo sapiens (Human) - RBPMS2 gene RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (PubMed:25064856). Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity). Taurus_UMD|evm.model.AC_000168.1.740 Q8NGR6 OR1B1_HUMAN 80.635 0.987421 1 OR1B1 - Olfactory receptor 1B1 - Homo sapiens (Human) - OR1B1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000168.1.741 Q8NGR5 OR1L4_HUMAN 85.852 0.99359 1.00322 OR1L4 - Olfactory receptor 1L4 - Homo sapiens (Human) - OR1L4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000168.1.742 P79103 RS4_BOVIN 82.890 0.991453 0.889734 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000168.1.743 Q2HJA9 PHLP_BOVIN 100.000 0.993377 1.00332 PDCL - Phosducin-like protein - Bos taurus (Bovine) - PDCL gene Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function. Taurus_UMD|evm.model.AC_000168.1.744 Q9HBD1 RC3H2_HUMAN 97.145 0.998319 0.99916 RC3H2 - Roquin-2 - Homo sapiens (Human) - RC3H2 gene Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670) (By similarity). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). Taurus_UMD|evm.model.AC_000168.1.745 Q13136 LIPA1_HUMAN 44.531 0.95122 0.0682196 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000168.1.746 Q0V8G8 ZBTB6_BOVIN 100.000 0.813462 1.22642 ZBTB6 - Zinc finger and BTB domain-containing protein 6 - Bos taurus (Bovine) - ZBTB6 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000168.1.747 Q9HCK0 ZBT26_HUMAN 99.093 0.995475 1.00227 ZBTB26 - Zinc finger and BTB domain-containing protein 26 - Homo sapiens (Human) - ZBTB26 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000168.1.748 Q5RAN1 RBGP1_PONAB 98.410 0.998131 1.00094 RABGAP1 - Rab GTPase-activating protein 1 - Pongo abelii (Sumatran orangutan) - RABGAP1 gene May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition (By similarity). Taurus_UMD|evm.model.AC_000168.1.750 Q08E27 STRBP_BOVIN 100.000 0.997028 1.00149 STRBP - Spermatid perinuclear RNA-binding protein - Bos taurus (Bovine) - STRBP gene Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity). Taurus_UMD|evm.model.AC_000168.1.752 Q5IJ48 CRUM2_HUMAN 80.978 0.99844 0.997665 CRB2 - Protein crumbs homolog 2 precursor - Homo sapiens (Human) - CRB2 gene Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo (By similarity). Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer (By similarity). The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB (By similarity). Plays a role in the maintenance of retinal neuroepithelium organization, structural integrity, adhesion, photoreceptor polarity and retinal photoreceptor layer thickness (By similarity). May play a role in determining the length of cone photoreceptor outer segments and proliferation of late-born progenitor cells (By similarity). Also required for maintenance of the apical polarity complex during development of the cortex (By similarity). Inhibits gamma-secretase-dependent cleavage of APP and secretion of amyloid-beta peptide 40 and amyloid-beta peptide 42, and thereby inhibits gamma-secretase-dependent Notch transcription (PubMed:20299451). Taurus_UMD|evm.model.AC_000168.1.753 Q8TEH3 DEN1A_HUMAN 89.635 0.998014 0.998018 DENND1A - DENN domain-containing protein 1A - Homo sapiens (Human) - DENND1A gene Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). Taurus_UMD|evm.model.AC_000168.1.754 P50458 LHX2_HUMAN 99.754 0.995086 1.00246 LHX2 - LIM/homeobox protein Lhx2 - Homo sapiens (Human) - LHX2 gene Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity). Taurus_UMD|evm.model.AC_000168.1.755 A2BD05 NEK6_PIG 98.083 0.685714 1.45367 NEK6 - Serine/threonine-protein kinase Nek6 - Sus scrofa (Pig) - NEK6 gene Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (By similarity). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity). Taurus_UMD|evm.model.AC_000168.1.756 Q2TBP0 PSB7_BOVIN 99.639 0.992806 1.00361 PSMB7 - Proteasome subunit beta type-7 precursor - Bos taurus (Bovine) - PSMB7 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity. Taurus_UMD|evm.model.AC_000168.1.757 Q7Z7M1 AGRD2_HUMAN 75.373 0.863469 1.12565 ADGRD2 - Adhesion G-protein coupled receptor D2 - Homo sapiens (Human) - ADGRD2 gene Orphan receptor. Taurus_UMD|evm.model.AC_000168.1.758 Q04752 STF1_BOVIN 100.000 0.995671 1.00217 NR5A1 - Steroidogenic factor 1 - Bos taurus (Bovine) - NR5A1 gene Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity). Taurus_UMD|evm.model.AC_000168.1.759 A0P8Z4 NR6A1_PIG 99.076 0.990826 0.91023 NR6A1 - Nuclear receptor subfamily 6 group A member 1 - Sus scrofa (Pig) - NR6A1 gene Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity). Taurus_UMD|evm.model.AC_000168.1.760 A2BD09 OLM2A_PIG 92.960 0.946646 1.00923 OLFML2A - Olfactomedin-like protein 2A precursor - Sus scrofa (Pig) - OLFML2A gene Taurus_UMD|evm.model.AC_000168.1.761 Q5JTN6 WDR38_HUMAN 80.068 0.993266 0.94586 WDR38 - WD repeat-containing protein 38 - Homo sapiens (Human) - WDR38 gene Taurus_UMD|evm.model.AC_000168.1.762 Q3MHM7 RL35_BOVIN 100.000 0.983871 1.00813 RPL35 - 60S ribosomal protein L35 - Bos taurus (Bovine) - RPL35 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000168.1.763 Q5E963 ARP5L_BOVIN 100.000 0.461883 1.45752 ARPC5L - Actin-related protein 2/3 complex subunit 5-like protein - Bos taurus (Bovine) - ARPC5L gene May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Taurus_UMD|evm.model.AC_000168.1.764 Q92805 GOGA1_HUMAN 85.677 0.92615 1.07692 GOLGA1 - Golgin subfamily A member 1 - Homo sapiens (Human) - GOLGA1 gene Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. Taurus_UMD|evm.model.AC_000168.1.765 Q8N9R8 SCAI_HUMAN 99.670 0.996705 1.00165 SCAI - Protein SCAI - Homo sapiens (Human) - SCAI gene Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. Taurus_UMD|evm.model.AC_000168.1.766 O00743 PPP6_HUMAN 100.000 0.993464 1.00328 PPP6C - Serine/threonine-protein phosphatase 6 catalytic subunit - Homo sapiens (Human) - PPP6C gene Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194). During mitosis, regulates spindle positioning (PubMed:27335426). Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228). Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation (PubMed:29053956). Taurus_UMD|evm.model.AC_000168.1.768 Q5EA50 RABEK_BOVIN 100.000 0.994638 1.00269 RABEPK - Rab9 effector protein with kelch motifs - Bos taurus (Bovine) - RABEPK gene Rab9 effector required for endosome to trans-Golgi network (TGN) transport. Taurus_UMD|evm.model.AC_000168.1.769 Q0VCX2 BIP_BOVIN 100.000 0.386454 0.766412 HSPA5 - Endoplasmic reticulum chaperone BiP precursor - Bos taurus (Bovine) - HSPA5 gene Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000168.1.770 Q14C86 GAPD1_HUMAN 97.566 0.998632 0.989175 GAPVD1 - GTPase-activating protein and VPS9 domain-containing protein 1 - Homo sapiens (Human) - GAPVD1 gene Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. Taurus_UMD|evm.model.AC_000168.1.772 P40426 PBX3_HUMAN 100.000 0.994444 0.829493 PBX3 - Pre-B-cell leukemia transcription factor 3 - Homo sapiens (Human) - PBX3 gene Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Taurus_UMD|evm.model.AC_000168.1.774 Q60564 LMX1B_MESAU 96.875 0.409091 0.417344 LMX1B - LIM homeobox transcription factor 1-beta - Mesocricetus auratus (Golden hamster) - LMX1B gene Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Mediates physical interaction and transcriptional synergy with E47/PAN-1. Taurus_UMD|evm.model.AC_000168.1.775 O60663 LMX1B_HUMAN 100.000 0.924051 0.78607 LMX1B - LIM homeobox transcription factor 1-beta - Homo sapiens (Human) - LMX1B gene Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Taurus_UMD|evm.model.AC_000168.1.776 O43298 ZBT43_HUMAN 98.069 0.931864 1.06852 ZBTB43 - Zinc finger and BTB domain-containing protein 43 - Homo sapiens (Human) - ZBTB43 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000168.1.777 Q8NCN2 ZBT34_HUMAN 96.813 0.988166 1.014 ZBTB34 - Zinc finger and BTB domain-containing protein 34 - Homo sapiens (Human) - ZBTB34 gene May be a transcriptional repressor. Taurus_UMD|evm.model.AC_000168.1.778 A2AR50 RGPS1_MOUSE 96.239 0.729089 1.36923 Ralgps1 - Ras-specific guanine nucleotide-releasing factor RalGPS1 - Mus musculus (Mouse) - Ralgps1 gene Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeleton organization. Taurus_UMD|evm.model.AC_000168.1.779 Q5VVW2 GARL3_HUMAN 93.939 0.951877 1.02567 GARNL3 - GTPase-activating Rap/Ran-GAP domain-like protein 3 - Homo sapiens (Human) - GARNL3 gene cytoplasm, GTPase activator activity, activation of GTPase activity Taurus_UMD|evm.model.AC_000168.1.780 P58354 GTR8_BOVIN 99.372 0.995825 1.00209 SLC2A8 - Solute carrier family 2, facilitated glucose transporter member 8 - Bos taurus (Bovine) - SLC2A8 gene Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate. Taurus_UMD|evm.model.AC_000168.1.781 Q15937 ZNF79_HUMAN 86.373 0.996 1.00402 ZNF79 - Zinc finger protein 79 - Homo sapiens (Human) - ZNF79 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000168.1.782 P30050 RL12_HUMAN 100.000 0.987952 1.00606 RPL12 - 60S ribosomal protein L12 - Homo sapiens (Human) - RPL12 gene Binds directly to 26S ribosomal RNA. Taurus_UMD|evm.model.AC_000168.1.783 Q6UWE0 LRSM1_HUMAN 91.172 0.997241 1.00277 LRSAM1 - E3 ubiquitin-protein ligase LRSAM1 - Homo sapiens (Human) - LRSAM1 gene E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). Taurus_UMD|evm.model.AC_000168.1.784 B4F7E8 NIBA2_RAT 91.444 0.997319 0.998661 Niban2 - Protein Niban 2 - Rattus norvegicus (Rat) - Niban2 gene May play a role in apoptosis suppression. Taurus_UMD|evm.model.AC_000168.1.785 P61765 STXB1_RAT 100.000 0.996639 1.00168 Stxbp1 - Syntaxin-binding protein 1 - Rattus norvegicus (Rat) - Stxbp1 gene Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (PubMed:21689256). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Taurus_UMD|evm.model.AC_000168.1.786 Q5JU67 CF157_HUMAN 70.286 0.996176 1.00577 CFAP157 - Cilia- and flagella-associated protein 157 - Homo sapiens (Human) - CFAP157 gene Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility. May be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure. Taurus_UMD|evm.model.AC_000168.1.787 Q86Y79 PTH_HUMAN 82.857 0.972093 1.00467 PTRH1 - Probable peptidyl-tRNA hydrolase - Homo sapiens (Human) - PTRH1 gene aminoacyl-tRNA hydrolase activity, RNA binding Taurus_UMD|evm.model.AC_000168.1.788 Q8NEE8 TTC16_HUMAN 63.933 0.885279 1.12829 TTC16 - Tetratricopeptide repeat protein 16 - Homo sapiens (Human) - TTC16 gene Taurus_UMD|evm.model.AC_000168.1.789 A4FUH1 TOR2A_BOVIN 100.000 0.993789 1.00312 TOR2A - Torsin-2A precursor - Bos taurus (Bovine) - TOR2A gene Taurus_UMD|evm.model.AC_000168.1.790 Q8N5H7 SH2D3_HUMAN 90.453 0.972125 1.00116 SH2D3C - SH2 domain-containing protein 3C - Homo sapiens (Human) - SH2D3C gene Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). Taurus_UMD|evm.model.AC_000168.1.791 Q5EAB2 CDK9_BOVIN 100.000 0.994638 1.00269 CDK9 - Cyclin-dependent kinase 9 - Bos taurus (Bovine) - CDK9 gene Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation. Taurus_UMD|evm.model.AC_000168.1.792 A6H751 FOLC_BOVIN 100.000 0.605974 1.20171 FPGS - Folylpolyglutamate synthase, mitochondrial precursor - Bos taurus (Bovine) - FPGS gene Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Taurus_UMD|evm.model.AC_000168.1.793 A6H751 FOLC_BOVIN 99.248 0.26087 0.864957 FPGS - Folylpolyglutamate synthase, mitochondrial precursor - Bos taurus (Bovine) - FPGS gene Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Taurus_UMD|evm.model.AC_000168.1.794 P00570 KAD1_BOVIN 100.000 0.989744 1.00515 AK1 - Adenylate kinase isoenzyme 1 - Bos taurus (Bovine) - AK1 gene Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Taurus_UMD|evm.model.AC_000168.1.795 Q08E15 SIA7F_BOVIN 98.780 0.893443 1.10241 ST6GALNAC6 - Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 - Bos taurus (Bovine) - ST6GALNAC6 gene Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (By similarity). Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity). Taurus_UMD|evm.model.AC_000168.1.796 Q9H4F1 SIA7D_HUMAN 91.060 0.833795 1.19536 ST6GALNAC4 - Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase - Homo sapiens (Human) - ST6GALNAC4 gene Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. Prefers O-glycans to glycoproteins or glycolipids. Taurus_UMD|evm.model.AC_000168.1.797 Q17QS4 PI5L1_BOVIN 85.227 0.874502 1.26768 PIP5KL1 - Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 - Bos taurus (Bovine) - PIP5KL1 gene May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. Taurus_UMD|evm.model.AC_000168.1.798 Q2KIN1 DPM2_BOVIN 98.795 0.828283 1.17857 DPM2 - Dolichol phosphate-mannose biosynthesis regulatory protein - Bos taurus (Bovine) - DPM2 gene Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the GPI-GNT complex. Taurus_UMD|evm.model.AC_000168.1.799 Q5T9C2 F102A_HUMAN 96.094 0.922705 1.07812 FAM102A - Protein FAM102A - Homo sapiens (Human) - FAM102A gene May play a role in estrogen action. Taurus_UMD|evm.model.AC_000168.1.800 A7MBH3 NAIF1_BOVIN 100.000 0.993902 1.00306 NAIF1 - Nuclear apoptosis-inducing factor 1 - Bos taurus (Bovine) - NAIF1 gene Induces apoptosis. Taurus_UMD|evm.model.AC_000168.1.801 Q0V7M4 SCMC2_BOVIN 99.760 0.828685 1.07036 SLC25A25 - Calcium-binding mitochondrial carrier protein SCaMC-2 - Bos taurus (Bovine) - SLC25A25 gene Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity). Taurus_UMD|evm.model.AC_000168.1.803 Q66LN0 PGES2_BOVIN 100.000 0.994638 1.00269 PTGES2 - Prostaglandin E synthase 2 - Bos taurus (Bovine) - PTGES2 gene Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:10446427, PubMed:11866447). The biological function and the GSH-dependent property of PTGES2 is still under debate (By similarity). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity). Taurus_UMD|evm.model.AC_000168.1.804 P80188 NGAL_HUMAN 69.274 0.820276 1.09596 LCN2 - Neutrophil gelatinase-associated lipocalin precursor - Homo sapiens (Human) - LCN2 gene Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:27780864, PubMed:20581821). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:27780864). Can also bind siderophores from M.tuberculosis (PubMed:15642259, PubMed:21978368). Taurus_UMD|evm.model.AC_000168.1.805 Q2NKS9 BBLN_BOVIN 100.000 0.97619 1.01205 BBLN - Bublin coiled-coil protein - Bos taurus (Bovine) - BBLN gene Taurus_UMD|evm.model.AC_000168.1.806 Q9ULV3 CIZ1_HUMAN 76.712 0.943375 0.983296 CIZ1 - Cip1-interacting zinc finger protein - Homo sapiens (Human) - CIZ1 gene May regulate the subcellular localization of CIP/WAF1. Taurus_UMD|evm.model.AC_000168.1.807 Q05193 DYN1_HUMAN 99.769 0.997688 1.00116 DNM1 - Dynamin-1 - Homo sapiens (Human) - DNM1 gene Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. Taurus_UMD|evm.model.AC_000168.1.808 H3BPF8 GOG8S_HUMAN 73.684 0.054211 1.6528 GOLGA8S - Golgin subfamily A member 8S - Homo sapiens (Human) - GOLGA8S gene cis-Golgi network, Golgi cis cisterna, Golgi cisterna membrane, Golgi organization Taurus_UMD|evm.model.AC_000168.1.809 Q1ZZU3 SWI5_HUMAN 86.022 0.92 0.425532 SWI5 - DNA repair protein SWI5 homolog - Homo sapiens (Human) - SWI5 gene Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. Taurus_UMD|evm.model.AC_000168.1.810 O95900 TRUB2_HUMAN 85.801 0.993976 1.00302 TRUB2 - Mitochondrial mRNA pseudouridine synthase TRUB2 precursor - Homo sapiens (Human) - TRUB2 gene Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Taurus_UMD|evm.model.AC_000168.1.811 Q05B52 COQ4_BOVIN 97.080 0.511278 1.76159 COQ4 - Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial precursor - Bos taurus (Bovine) - COQ4 gene Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides (By similarity). Taurus_UMD|evm.model.AC_000168.1.812 Q5RDY4 S27A4_PONAB 88.958 0.996894 1.00156 SLC27A4 - Long-chain fatty acid transport protein 4 - Pongo abelii (Sumatran orangutan) - SLC27A4 gene Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs) (By similarity). Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (By similarity). Probably involved in fatty acid transport across the blood barrier (By similarity). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity). Taurus_UMD|evm.model.AC_000168.1.813 A9YUB5 URM1_CAPHI 100.000 0.980392 1.0099 URM1 - Ubiquitin-related modifier 1 - Capra hircus (Goat) - URM1 gene Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. Taurus_UMD|evm.model.AC_000168.1.815 A8D8X1 RL10_SHEEP 68.868 0.689655 0.67757 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000168.1.816 A7MB73 GT253_BOVIN 100.000 0.996139 0.870588 CERCAM - Probable inactive glycosyltransferase 25 family member 3 precursor - Bos taurus (Bovine) - CERCAM gene Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro. Taurus_UMD|evm.model.AC_000168.1.817 Q2T9U2 ODFP2_BOVIN 97.865 0.632292 1.46119 ODF2 - Outer dense fiber protein 2 - Bos taurus (Bovine) - ODF2 gene Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly (By similarity). Taurus_UMD|evm.model.AC_000168.1.818 Q3ZBK7 GLE1_BOVIN 100.000 0.997139 1.00143 GLE1 - Nucleoporin GLE1 - Bos taurus (Bovine) - GLE1 gene Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). Taurus_UMD|evm.model.AC_000168.1.819 Q13813 SPTN1_HUMAN 99.110 0.994366 1.00526 SPTAN1 - Spectrin alpha chain, non-erythrocytic 1 - Homo sapiens (Human) - SPTAN1 gene Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Taurus_UMD|evm.model.AC_000168.1.820 Q5U4F6 DC2I2_MOUSE 84.524 0.934823 1 Dync2i2 - Cytoplasmic dynein 2 intermediate chain 2 - Mus musculus (Mouse) - Dync2i2 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis (PubMed:28379358). Required also to maintain a functional transition zone (By similarity). Taurus_UMD|evm.model.AC_000168.1.821 Q01105 SET_HUMAN 91.213 0.808874 1.01034 SET - Protein SET - Homo sapiens (Human) - SET gene Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. Taurus_UMD|evm.model.AC_000168.1.822 Q6P5Z2 PKN3_HUMAN 90.101 0.997753 1.00112 PKN3 - Serine/threonine-protein kinase N3 - Homo sapiens (Human) - PKN3 gene Contributes to invasiveness in malignant prostate cancer. Taurus_UMD|evm.model.AC_000168.1.823 Q96GR4 ZDH12_HUMAN 93.657 0.992565 1.00749 ZDHHC12 - Palmitoyltransferase ZDHHC12 - Homo sapiens (Human) - ZDHHC12 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering. Thereby, indirectly regulates GABAergic synaptic transmission. Taurus_UMD|evm.model.AC_000168.1.824 Q5RAG3 ZER1_PONAB 98.303 0.997392 1.00131 ZER1 - Protein zer-1 homolog - Pongo abelii (Sumatran orangutan) - ZER1 gene Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation. Taurus_UMD|evm.model.AC_000168.1.825 Q9NVG8 TBC13_HUMAN 96.000 0.995 1 TBC1D13 - TBC1 domain family member 13 - Homo sapiens (Human) - TBC1D13 gene Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. Taurus_UMD|evm.model.AC_000168.1.826 P38447 NUCG_BOVIN 100.000 0.993333 1.00334 ENDOG - Endonuclease G, mitochondrial precursor - Bos taurus (Bovine) - ENDOG gene Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. Taurus_UMD|evm.model.AC_000168.1.827 Q5T280 CI114_HUMAN 94.385 0.98939 1.00266 SPOUT1 - Putative methyltransferase C9orf114 - Homo sapiens (Human) - SPOUT1 gene Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:20813266, PubMed:25657325). Also involved in chromosome alignment (PubMed:20813266). May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis (PubMed:25657325). Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level (PubMed:28431233). Taurus_UMD|evm.model.AC_000168.1.828 Q16773 KAT1_HUMAN 85.816 0.99061 1.00948 KYAT1 - Kynurenine--oxoglutarate transaminase 1 - Homo sapiens (Human) - KYAT1 gene Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:19338303, PubMed:28097769). Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites (PubMed:7883047). Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:7883047). Taurus_UMD|evm.model.AC_000168.1.829 Q8IWT6 LRC8A_HUMAN 99.012 0.997534 1.00123 LRRC8A - Volume-regulated anion channel subunit LRRC8A - Homo sapiens (Human) - LRRC8A gene Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubMed:29769723, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24725410, PubMed:30095067, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). In complex with LRRC8C or LRRC8E, acts as a transporter of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol: mediates both import and export of 2'-3'-cGAMP, thereby promoting transfer of 2'-3'-cGAMP to bystander cells (PubMed:33171122). In contrast, complexes containing LRRC8D inhibit transport of 2'-3'-cGAMP (PubMed:33171122). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Can form functional channels by itself (in vitro) (PubMed:26824658). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746). Also required for T-cell development (By similarity). Required for myoblast differentiation: VRAC activity promotes membrane hyperpolarization and regulates insulin-stimulated glucose metabolism and oxygen consumption (By similarity). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29371604). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (PubMed:31270356, PubMed:33139539). Taurus_UMD|evm.model.AC_000168.1.831 Q0IIB1 PHYD1_BOVIN 99.656 0.993151 1.00344 PHYHD1 - Phytanoyl-CoA dioxygenase domain-containing protein 1 - Bos taurus (Bovine) - PHYHD1 gene Has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA (By similarity). Taurus_UMD|evm.model.AC_000168.1.832 Q58CR4 DOLK_BOVIN 100.000 0.996289 1.00186 DOLK - Dolichol kinase - Bos taurus (Bovine) - DOLK gene Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. Taurus_UMD|evm.model.AC_000168.1.833 Q5SRE5 NU188_HUMAN 96.059 0.998858 1.00172 NUP188 - Nucleoporin NUP188 - Homo sapiens (Human) - NUP188 gene Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). Taurus_UMD|evm.model.AC_000168.1.834 Q08DK5 SHLB2_BOVIN 100.000 0.994949 1.00253 SH3GLB2 - Endophilin-B2 - Bos taurus (Bovine) - SH3GLB2 gene Taurus_UMD|evm.model.AC_000168.1.835 Q1JPG0 MIGA2_BOVIN 100.000 0.996633 1.00169 MIGA2 - Mitoguardin 2 - Bos taurus (Bovine) - MIGA2 gene Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. Taurus_UMD|evm.model.AC_000168.1.836 B0KWE9 DOPP1_CALJA 96.218 0.991632 1.0042 DOLPP1 - Dolichyldiphosphatase 1 - Callithrix jacchus (White-tufted-ear marmoset) - DOLPP1 gene Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity). Taurus_UMD|evm.model.AC_000168.1.837 P43155 CACP_HUMAN 92.652 0.99681 1.0016 CRAT - Carnitine O-acetyltransferase - Homo sapiens (Human) - CRAT gene Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation (PubMed:15099582, PubMed:29395073). Responsible for the synthesis of short- and branched-chain acylcarnitines (PubMed:23485643). Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates (PubMed:23485643). Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates (PubMed:23485643). Taurus_UMD|evm.model.AC_000168.1.839 Q2KJ44 PTPA_BOVIN 100.000 0.993846 1.00309 PTPA - Serine/threonine-protein phosphatase 2A activator - Bos taurus (Bovine) - PTPA gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A (By similarity). Taurus_UMD|evm.model.AC_000168.1.840 Q6PBC9 IER5L_XENTR 98.305 0.143921 1.36149 ier5l - Immediate early response gene 5-like protein - Xenopus tropicalis (Western clawed frog) - ier5l gene Taurus_UMD|evm.model.AC_000168.1.842 Q5SZB4 CI050_HUMAN 53.089 0.968109 1.01856 C9orf50 - Uncharacterized protein C9orf50 - Homo sapiens (Human) - C9orf50 gene Taurus_UMD|evm.model.AC_000168.1.843 Q2T9N3 NTM1A_BOVIN 99.552 0.991071 1.00448 NTMT1 - N-terminal Xaa-Pro-Lys N-methyltransferase 1 - Bos taurus (Bovine) - NTMT1 gene Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. Taurus_UMD|evm.model.AC_000168.1.845 Q9NWX5 ASB6_HUMAN 94.537 0.995261 1.00238 ASB6 - Ankyrin repeat and SOCS box protein 6 - Homo sapiens (Human) - ASB6 gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000168.1.846 Q99811 PRRX2_HUMAN 97.468 0.862637 0.719368 PRRX2 - Paired mesoderm homeobox protein 2 - Homo sapiens (Human) - PRRX2 gene May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development. Taurus_UMD|evm.model.AC_000168.1.847 Q95L14 PTGES_BOVIN 100.000 0.987013 1.00654 PTGES - Prostaglandin E synthase - Bos taurus (Bovine) - PTGES gene Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (By similarity). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity). Taurus_UMD|evm.model.AC_000168.1.848 O14657 TOR1B_HUMAN 92.727 0.83792 0.973214 TOR1B - Torsin-1B precursor - Homo sapiens (Human) - TOR1B gene May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues. Taurus_UMD|evm.model.AC_000168.1.849 Q60HG2 TOR1A_MACFA 93.417 0.952096 1.00602 TOR1A - Torsin-1A precursor - Macaca fascicularis (Crab-eating macaque) - TOR1A gene Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues (By similarity). Taurus_UMD|evm.model.AC_000168.1.850 Q9NZ63 TLS1_HUMAN 98.616 0.993103 1.00346 C9orf78 - Telomere length and silencing protein 1 homolog - Homo sapiens (Human) - C9orf78 gene Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. Taurus_UMD|evm.model.AC_000168.1.851 B0BN18 PFD2_RAT 77.064 0.870968 0.805195 Pfdn2 - Prefoldin subunit 2 - Rattus norvegicus (Rat) - Pfdn2 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Taurus_UMD|evm.model.AC_000168.1.852 A7Z056 UBP20_BOVIN 100.000 0.997809 1.0011 USP20 - Ubiquitin carboxyl-terminal hydrolase 20 - Bos taurus (Bovine) - USP20 gene Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Taurus_UMD|evm.model.AC_000168.1.854 Q96RU3 FNBP1_HUMAN 93.750 0.966292 1.00972 FNBP1 - Formin-binding protein 1 - Homo sapiens (Human) - FNBP1 gene May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. Taurus_UMD|evm.model.AC_000168.1.855 Q5VW38 GP107_HUMAN 83.914 0.994614 0.928333 GPR107 - Protein GPR107 precursor - Homo sapiens (Human) - GPR107 gene Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (PubMed:22933024). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). Taurus_UMD|evm.model.AC_000168.1.857 P62168 NCS1_RAT 93.011 0.800866 1.21579 Ncs1 - Neuronal calcium sensor 1 - Rattus norvegicus (Rat) - Ncs1 gene Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel. Taurus_UMD|evm.model.AC_000168.1.860 Q8NDA2 HMCN2_HUMAN 82.956 0.99921 1.00138 HMCN2 - Hemicentin-2 precursor - Homo sapiens (Human) - HMCN2 gene collagen-containing extracellular matrix, extracellular matrix, extracellular space Taurus_UMD|evm.model.AC_000168.1.861 P14568 ASSY_BOVIN 100.000 0.995157 1.00243 ASS1 - Argininosuccinate synthase - Bos taurus (Bovine) - ASS1 gene One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. Taurus_UMD|evm.model.AC_000168.1.862 Q96I24 FUBP3_HUMAN 95.105 0.99651 1.00175 FUBP3 - Far upstream element-binding protein 3 - Homo sapiens (Human) - FUBP3 gene May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Taurus_UMD|evm.model.AC_000168.1.863 A2AJ77 PRD12_MOUSE 98.082 0.994475 0.991781 Prdm12 - PR domain zinc finger protein 12 - Mus musculus (Mouse) - Prdm12 gene Involved in the positive regulation of histone H3-K9 dimethylation. Taurus_UMD|evm.model.AC_000168.1.864 Q2KID0 EXOS2_BOVIN 100.000 0.993197 1.00341 EXOSC2 - Exosome complex component RRP4 - Bos taurus (Bovine) - EXOSC2 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7 (By similarity). Taurus_UMD|evm.model.AC_000168.1.865 P10447 ABL_FSVHY 98.861 0.380208 2.62415 ABL - Tyrosine-protein kinase transforming protein Abl - Feline sarcoma virus (strain Hardy-Zuckerman 2) - ABL gene Taurus_UMD|evm.model.AC_000168.1.866 P83862 OX26_BOVIN 99.248 0.977778 1.00746 QRFP - Orexigenic neuropeptide QRFP precursor - Bos taurus (Bovine) - QRFP gene Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity). Taurus_UMD|evm.model.AC_000168.1.867 Q8N539 FBCD1_HUMAN 91.964 0.988938 0.980477 FIBCD1 - Fibrinogen C domain-containing protein 1 - Homo sapiens (Human) - FIBCD1 gene Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components. Taurus_UMD|evm.model.AC_000168.1.868 Q9Y6N6 LAMC3_HUMAN 86.518 0.483196 1.00127 LAMC3 - Laminin subunit gamma-3 precursor - Homo sapiens (Human) - LAMC3 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Taurus_UMD|evm.model.AC_000168.1.869 P35658 NU214_HUMAN 82.468 0.999043 1 NUP214 - Nuclear pore complex protein Nup214 - Homo sapiens (Human) - NUP214 gene Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). Taurus_UMD|evm.model.AC_000168.1.870 Q8C552 FA78A_MOUSE 96.466 0.992958 1.00353 Fam78a - Protein FAM78A - Mus musculus (Mouse) - Fam78a gene Taurus_UMD|evm.model.AC_000168.1.873 Q8NBV4 PLPP7_HUMAN 94.465 0.992647 1.00369 PLPP7 - Inactive phospholipid phosphatase 7 - Homo sapiens (Human) - PLPP7 gene Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity). Taurus_UMD|evm.model.AC_000168.1.874 Q7TPM1 PRC2B_MOUSE 85.516 0.348138 1.5 Prrc2b - Protein PRRC2B - Mus musculus (Mouse) - Prrc2b gene cell differentiation, in utero embryonic development Taurus_UMD|evm.model.AC_000168.1.876 Q8R2R1 POMT1_MOUSE 85.497 0.995868 0.97319 Pomt1 - Protein O-mannosyl-transferase 1 - Mus musculus (Mouse) - Pomt1 gene Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins. Taurus_UMD|evm.model.AC_000168.1.877 Q0P5A4 UCK1_BOVIN 100.000 0.992806 1.00361 UCK1 - Uridine-cytidine kinase 1 - Bos taurus (Bovine) - UCK1 gene Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor (By similarity). Taurus_UMD|evm.model.AC_000168.1.878 A0A1B0GWB2 PRT1B_HUMAN 66.426 0.984375 0.973384 PRRT1B - Proline rich transmembrane protein 1B - Homo sapiens (Human) - PRRT1B gene membrane Taurus_UMD|evm.model.AC_000168.1.879 Q13905 RPGF1_HUMAN 91.396 0.477855 1.19499 RAPGEF1 - Rap guanine nucleotide exchange factor 1 - Homo sapiens (Human) - RAPGEF1 gene Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. Taurus_UMD|evm.model.AC_000168.1.881 Q2TBN7 MED27_BOVIN 100.000 0.99359 1.00322 MED27 - Mediator of RNA polymerase II transcription subunit 27 - Bos taurus (Bovine) - MED27 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Taurus_UMD|evm.model.AC_000168.1.882 Q96CW9 NTNG2_HUMAN 95.728 0.966165 1.00377 NTNG2 - Netrin-G2 precursor - Homo sapiens (Human) - NTNG2 gene Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. Taurus_UMD|evm.model.AC_000168.1.883 Q7Z333 SETX_HUMAN 78.961 0.998289 0.436683 SETX - Probable helicase senataxin - Homo sapiens (Human) - SETX gene Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). Taurus_UMD|evm.model.AC_000168.1.884 Q7Z333 SETX_HUMAN 76.551 0.982833 0.522226 SETX - Probable helicase senataxin - Homo sapiens (Human) - SETX gene Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). Taurus_UMD|evm.model.AC_000168.1.885 Q15361 TTF1_HUMAN 72.037 0.687664 0.841989 TTF1 - Transcription termination factor 1 - Homo sapiens (Human) - TTF1 gene Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. Taurus_UMD|evm.model.AC_000168.1.886 Q6ZQR2 CFA77_HUMAN 81.562 0.992982 0.890625 CFAP77 - Cilia- and flagella-associated protein 77 - Homo sapiens (Human) - CFAP77 gene Taurus_UMD|evm.model.AC_000168.1.888 Q9BZE3 BARH1_HUMAN 98.777 0.993902 1.00306 BARHL1 - BarH-like 1 homeobox protein - Homo sapiens (Human) - BARHL1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000168.1.889 Q9H8H2 DDX31_HUMAN 79.533 0.986431 0.86604 DDX31 - Probable ATP-dependent RNA helicase DDX31 - Homo sapiens (Human) - DDX31 gene Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 (PubMed:23019224). Taurus_UMD|evm.model.AC_000168.1.890 Q9UKN8 TF3C4_HUMAN 92.092 0.997543 0.990268 GTF3C4 - General transcription factor 3C polypeptide 4 - Homo sapiens (Human) - GTF3C4 gene Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box. Taurus_UMD|evm.model.AC_000168.1.891 Q96MA6 KAD8_HUMAN 82.255 0.957916 1.04175 AK8 - Adenylate kinase 8 - Homo sapiens (Human) - AK8 gene Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Taurus_UMD|evm.model.AC_000168.1.892 Q96E40 SACA9_HUMAN 90.854 0.693617 1.05856 SPACA9 - Sperm acrosome-associated protein 9 - Homo sapiens (Human) - SPACA9 gene acrosomal vesicle, ciliary basal body, ciliary base, cytoplasmic microtubule, nucleus, sperm flagellum Taurus_UMD|evm.model.AC_000168.1.893 Q92574 TSC1_HUMAN 88.069 0.998276 0.996564 TSC1 - Hamartin - Homo sapiens (Human) - TSC1 gene In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Seems not to be required for TSC2 GAP activity towards RHEB (PubMed:15340059). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). Taurus_UMD|evm.model.AC_000168.1.894 Q5VTD9 GFI1B_HUMAN 88.822 0.993976 1.00606 GFI1B - Zinc finger protein Gfi-1b - Homo sapiens (Human) - GFI1B gene Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation. Taurus_UMD|evm.model.AC_000168.1.895 Q9Y5Q8 TF3C5_HUMAN 81.818 0.996283 1.03661 GTF3C5 - General transcription factor 3C polypeptide 5 - Homo sapiens (Human) - GTF3C5 gene Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. Taurus_UMD|evm.model.AC_000168.1.896 P30122 CEL_BOVIN 99.659 0.975 1.00503 CEL - Bile salt-activated lipase precursor - Bos taurus (Bovine) - CEL gene Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA) (PubMed:10220579). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). Taurus_UMD|evm.model.AC_000168.1.897 Q12967 GNDS_HUMAN 84.543 0.982737 0.887309 RALGDS - Ral guanine nucleotide dissociation stimulator - Homo sapiens (Human) - RALGDS gene Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. Taurus_UMD|evm.model.AC_000168.1.898 Q95158 GBGT1_CANLF 81.844 0.994236 1 GBGT1 - Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 - Canis lupus familiaris (Dog) - GBGT1 gene Catalyzes the formation of Forssman glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to GalNAcb-1,3Gala-1,4Galb-1,4GlcCer (Gb4Cer) (PubMed:8855242, PubMed:10506200). Forssman glycolipid (also called Forssman antigen; FG) probably serves for adherence of some pathogens such as E.coli uropathogenic strains (PubMed:10506200). Taurus_UMD|evm.model.AC_000168.1.899 Q03386 GNDS_RAT 60.902 0.767606 0.158659 Ralgds - Ral guanine nucleotide dissociation stimulator - Rattus norvegicus (Rat) - Ralgds gene Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. Taurus_UMD|evm.model.AC_000168.1.900 P07380 LACB2_HORSE 64.885 0.159705 4.49724 LGB2 - Beta-lactoglobulin-2 precursor - Equus caballus (Horse) - LGB2 gene Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule. Taurus_UMD|evm.model.AC_000168.1.901 P02754 LACB_BOVIN 99.438 0.988827 1.00562 LGB - Beta-lactoglobulin precursor - Bos taurus (Bovine) - LGB gene Primary component of whey, it binds retinol and is probably involved in the transport of that molecule. Taurus_UMD|evm.model.AC_000168.1.903 Q2YDM8 GL6D1_BOVIN 99.675 0.993528 1.00325 GLT6D1 - Glycosyltransferase 6 domain-containing protein 1 - Bos taurus (Bovine) - GLT6D1 gene Taurus_UMD|evm.model.AC_000168.1.904 Q9D267 LCN9_MOUSE 44.872 0.536332 1.6236 Lcn9 - Epididymal-specific lipocalin-9 precursor - Mus musculus (Mouse) - Lcn9 gene extracellular space Taurus_UMD|evm.model.AC_000168.1.905 Q5JUK2 SOLH1_HUMAN 46.541 0.779104 1.02134 SOHLH1 - Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 - Homo sapiens (Human) - SOHLH1 gene Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity). Taurus_UMD|evm.model.AC_000168.1.907 Q5JUK3 KCNT1_HUMAN 94.182 0.886228 1.08618 KCNT1 - Potassium channel subfamily T member 1 - Homo sapiens (Human) - KCNT1 gene Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity). Taurus_UMD|evm.model.AC_000168.1.909 Q5T5Y3 CAMP1_HUMAN 78.629 0.998729 0.982522 CAMSAP1 - Calmodulin-regulated spectrin-associated protein 1 - Homo sapiens (Human) - CAMSAP1 gene Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24486153, PubMed:24706919, PubMed:24117850). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). Taurus_UMD|evm.model.AC_000168.1.910 Q9BSL1 UBAC1_HUMAN 87.407 0.995037 0.995062 UBAC1 - Ubiquitin-associated domain-containing protein 1 - Homo sapiens (Human) - UBAC1 gene Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. Taurus_UMD|evm.model.AC_000168.1.911 Q96BF6 NACC2_HUMAN 93.919 0.424638 1.17547 NACC2 - Nucleus accumbens-associated protein 2 - Homo sapiens (Human) - NACC2 gene Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. Taurus_UMD|evm.model.AC_000168.1.912 H0YL14 TM250_HUMAN 93.525 0.985714 1.00719 TMEM250 - Transmembrane protein 250 - Homo sapiens (Human) - TMEM250 gene May play a role in cell proliferation by promoting progression into S phase. Taurus_UMD|evm.model.AC_000168.1.913 O97581 LHX3_PIG 95.979 0.920792 1.05483 LHX3 - LIM/homeobox protein Lhx3 - Sus scrofa (Pig) - LHX3 gene Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Taurus_UMD|evm.model.AC_000168.1.914 Q6ZRP7 QSOX2_HUMAN 77.213 0.994211 0.989971 QSOX2 - Sulfhydryl oxidase 2 precursor - Homo sapiens (Human) - QSOX2 gene Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis. Taurus_UMD|evm.model.AC_000168.1.915 A0A096LP49 CC187_HUMAN 53.265 0.429795 1.97648 CCDC187 - Coiled-coil domain-containing protein 187 - Homo sapiens (Human) - CCDC187 gene Taurus_UMD|evm.model.AC_000168.1.917 Q9R080 GPSM1_RAT 92.571 0.997028 1 Gpsm1 - G-protein-signaling modulator 1 - Rattus norvegicus (Rat) - Gpsm1 gene Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Taurus_UMD|evm.model.AC_000168.1.918 Q5SXM8 DNLZ_HUMAN 71.910 0.988235 0.955056 DNLZ - DNL-type zinc finger protein precursor - Homo sapiens (Human) - DNLZ gene May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation. Taurus_UMD|evm.model.AC_000168.1.919 Q9H257 CARD9_HUMAN 77.138 0.990385 0.970149 CARD9 - Caspase recruitment domain-containing protein 9 - Homo sapiens (Human) - CARD9 gene Adapter protein that plays a key role in innate immune response against fungi by forming signaling complexes downstream of C-type lectin receptors (PubMed:26961233, PubMed:33558980). CARD9-mediated signals are essential for antifungal immunity against a subset of fungi from the phylum Ascomycota (PubMed:24231284, PubMed:25702837, PubMed:25057046, PubMed:26679537, PubMed:26961233, PubMed:26521038, PubMed:27777981, PubMed:29080677, PubMed:33558980). Transduces signals in myeloid cells downstream of C-type lectin receptors CLEC7A (dectin-1), CLEC6A (dectin-2) and CLEC4E (Mincle), which detect pathogen-associated molecular pattern metabolites (PAMPs), such as fungal carbohydrates, and trigger CARD9 activation (By similarity). Upon activation, CARD9 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11053425, PubMed:26488816, PubMed:31296852, PubMed:26961233, PubMed:33558980). CARD9 signaling in antigen-presenting cells links innate sensing of fungi to the activation of adaptive immunity and provides a cytokine milieu that induces the development and subsequent of interleukin 17-producing T helper (Th17) cells (PubMed:24231284). Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). CARD9 can also be engaged independently of BCL10: forms a complex with RASGRF1 downstream of C-type lectin receptors, which recruits and activates HRAS, leading to ERK activation and the production of cytokines (By similarity). Acts as an important regulator of the intestinal commensal fungi (mycobiota) component of the gut microbiota (PubMed:33548172). Plays an essential role in antifungal immunity against dissemination of gut fungi: acts by promoting induction of antifungal IgG antibodies response in CX3CR1(+) macrophages to confer protection against disseminated C.albicans or C.auris infection (PubMed:33548172). Also mediates immunity against other pathogens, such as certain bacteria, viruses and parasites; CARD9 signaling is however redundant with other innate immune responses (By similarity). In response to L.monocytogenes infection, required for the production of inflammatory cytokines activated by intracellular peptidoglycan: acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B (By similarity). Taurus_UMD|evm.model.AC_000168.1.920 Q5SXM2 SNPC4_HUMAN 58.132 0.997724 0.897209 SNAPC4 - snRNA-activating protein complex subunit 4 - Homo sapiens (Human) - SNAPC4 gene Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. Taurus_UMD|evm.model.AC_000168.1.921 Q2KJD6 ENTR1_BOVIN 100.000 0.0531401 1.1532 ENTR1 - Endosome-associated-trafficking regulator 1 - Bos taurus (Bovine) - ENTR1 gene Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis. Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1. Plays a role in the formation of cilia. Involved in cargo protein localization, such as PKD2, at primary cilia (By similarity). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity). Taurus_UMD|evm.model.AC_000168.1.922 Q0P5M8 MPPA_BOVIN 100.000 0.996198 1.0019 PMPCA - Mitochondrial-processing peptidase subunit alpha precursor - Bos taurus (Bovine) - PMPCA gene Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Taurus_UMD|evm.model.AC_000168.1.923 Q9NRR6 INP5E_HUMAN 74.468 0.996956 1.02019 INPP5E - Phosphatidylinositol polyphosphate 5-phosphatase type IV precursor - Homo sapiens (Human) - INPP5E gene Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:10764818) (By similarity). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity). Taurus_UMD|evm.model.AC_000168.1.924 O15027 SC16A_HUMAN 67.015 0.981029 1.00636 SEC16A - Protein transport protein Sec16A - Homo sapiens (Human) - SEC16A gene Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:17005010, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). Taurus_UMD|evm.model.AC_000168.1.925 P46531 NOTC1_HUMAN 87.912 0.991736 0.994521 NOTCH1 - Neurogenic locus notch homolog protein 1 precursor - Homo sapiens (Human) - NOTCH1 gene Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Taurus_UMD|evm.model.AC_000168.1.926 Q6AZ60 EGFL7_RAT 67.857 0.56701 0.34767 Egfl7 - Epidermal growth factor-like protein 7 precursor - Rattus norvegicus (Rat) - Egfl7 gene Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis (By similarity). Taurus_UMD|evm.model.AC_000168.1.928 Q8K3K7 PLCB_MOUSE 83.240 0.777293 0.823741 Agpat2 - 1-acyl-sn-glycerol-3-phosphate acyltransferase beta precursor - Mus musculus (Mouse) - Agpat2 gene Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Taurus_UMD|evm.model.AC_000168.1.929 Q5VUD6 DIK1B_HUMAN 85.158 0.903084 1.05336 DIPK1B - Divergent protein kinase domain 1B - Homo sapiens (Human) - DIPK1B gene Taurus_UMD|evm.model.AC_000168.1.930 Q3SYR7 RL9_BOVIN 99.479 0.989637 1.00521 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000168.1.931 P38649 BGAT_MOUSE 72.222 0.753968 1.13855 Abo - Histo-blood group ABO system transferase - Mus musculus (Mouse) - Abo gene cytoplasmic vesicle, Golgi apparatus, vesicle, alpha-1,3-galactosyltransferase activity, antigen binding, fucosylgalactoside 3-alpha-galactosyltransferase activity, glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity, manganese ion binding, nucleotide binding, transferase activity, transferring glycosyl groups Taurus_UMD|evm.model.AC_000168.1.932 Q0VCY3 SURF6_BOVIN 100.000 0.99435 1.00283 SURF6 - Surfeit locus protein 6 - Bos taurus (Bovine) - SURF6 gene Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). Taurus_UMD|evm.model.AC_000168.1.933 Q5E9K2 MED22_BOVIN 100.000 0.990099 1.00498 MED22 - Mediator of RNA polymerase II transcription subunit 22 - Bos taurus (Bovine) - MED22 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Taurus_UMD|evm.model.AC_000168.1.934 Q2TBQ5 RL7A_BOVIN 100.000 0.992509 1.00376 RPL7A - 60S ribosomal protein L7a - Bos taurus (Bovine) - RPL7A gene cytosolic large ribosomal subunit, RNA binding, maturation of LSU-rRNA Taurus_UMD|evm.model.AC_000168.1.935 Q15526 SURF1_HUMAN 82.623 0.987013 1.02667 SURF1 - Surfeit locus protein 1 - Homo sapiens (Human) - SURF1 gene Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Taurus_UMD|evm.model.AC_000168.1.936 Q15527 SURF2_HUMAN 77.992 0.992278 1.01172 SURF2 - Surfeit locus protein 2 - Homo sapiens (Human) - SURF2 gene nuclear speck, nucleolus, nucleoplasm, plasma membrane Taurus_UMD|evm.model.AC_000168.1.937 A7YY49 SURF4_BOVIN 100.000 0.992593 1.00372 SURF4 - Surfeit locus protein 4 - Bos taurus (Bovine) - SURF4 gene May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Taurus_UMD|evm.model.AC_000168.1.938 Q8NE28 STKL1_HUMAN 67.385 0.922857 1.02941 STKLD1 - Serine/threonine kinase-like domain-containing protein STKLD1 - Homo sapiens (Human) - STKLD1 gene protein serine/threonine kinase activity Taurus_UMD|evm.model.AC_000168.1.939 Q9GZR2 REXO4_HUMAN 64.252 0.995134 0.973934 REXO4 - RNA exonuclease 4 - Homo sapiens (Human) - REXO4 gene nuclear speck, nucleolus, nucleoplasm, nucleus, 3'-5' exonuclease activity, double-stranded DNA binding, endonuclease activity, exonuclease activity, RNA binding, single-stranded DNA binding Taurus_UMD|evm.model.AC_000168.1.940 Q76LX8 ATS13_HUMAN 67.127 0.994448 1.00981 ADAMTS13 - A disintegrin and metalloproteinase with thrombospondin motifs 13 precursor - Homo sapiens (Human) - ADAMTS13 gene Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. Taurus_UMD|evm.model.AC_000168.1.941 Q8BG21 FLOWR_MOUSE 90.260 0.884393 1.0117 Cacfd1 - Calcium channel flower homolog - Mus musculus (Mouse) - Cacfd1 gene vesicle-mediated transport Taurus_UMD|evm.model.AC_000168.1.942 Q9UGQ3 GTR6_HUMAN 87.179 0.996063 1.00197 SLC2A6 - Solute carrier family 2, facilitated glucose transporter member 6 - Homo sapiens (Human) - SLC2A6 gene Probable sugar transporter that acts as a regulator of glycolysis in macrophages (Probable). Does not transport glucose (PubMed:30431159). Taurus_UMD|evm.model.AC_000168.1.944 A6NI61 MYMK_HUMAN 91.403 0.990991 1.00452 MYMK - Protein myomaker - Homo sapiens (Human) - MYMK gene Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:28681861). Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of MYMX. Acts independently of MYMX (By similarity). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (By similarity). Also involved in skeletal muscle hypertrophy, probably by mediating the fusion of satellite cells with myofibers (By similarity). Taurus_UMD|evm.model.AC_000168.1.945 Q86TH1 ATL2_HUMAN 89.005 0.997908 1.00526 ADAMTSL2 - ADAMTS-like protein 2 precursor - Homo sapiens (Human) - ADAMTSL2 gene extracellular matrix, metalloendopeptidase activity, extracellular matrix organization, negative regulation of transforming growth factor beta receptor signaling pathway Taurus_UMD|evm.model.AC_000168.1.946 Q8BUM6 F163B_MOUSE 87.425 0.98773 0.976048 Fam163b - Protein FAM163B - Mus musculus (Mouse) - Fam163b gene Taurus_UMD|evm.model.AC_000168.1.947 P15101 DOPO_BOVIN 100.000 0.996727 1.00164 DBH - Dopamine beta-hydroxylase - Bos taurus (Bovine) - DBH gene Conversion of dopamine to noradrenaline. Taurus_UMD|evm.model.AC_000168.1.948 Q9UL12 SARDH_HUMAN 87.378 0.997826 1.00218 SARDH - Sarcosine dehydrogenase, mitochondrial precursor - Homo sapiens (Human) - SARDH gene cytoplasm, mitochondrial matrix, mitochondrion, oxidoreductase activity, sarcosine dehydrogenase activity, choline catabolic process, sarcosine catabolic process Taurus_UMD|evm.model.AC_000168.1.949 Q60992 VAV2_MOUSE 89.415 0.992298 0.897465 Vav2 - Guanine nucleotide exchange factor VAV2 - Mus musculus (Mouse) - Vav2 gene Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Taurus_UMD|evm.model.AC_000168.1.950 Q9R0C8 VAV3_MOUSE 72.222 0.180412 0.229044 Vav3 - Guanine nucleotide exchange factor VAV3 - Mus musculus (Mouse) - Vav3 gene Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion. Taurus_UMD|evm.model.AC_000168.1.951 A0A1B0GUI7 BRDOS_HUMAN 92.857 0.976471 1.0119 BRD3OS - Putative uncharacterized protein BRD3OS - Homo sapiens (Human) - BRD3OS gene Taurus_UMD|evm.model.AC_000168.1.952 Q15059 BRD3_HUMAN 92.593 0.964039 0.995868 BRD3 - Bromodomain-containing protein 3 - Homo sapiens (Human) - BRD3 gene Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Taurus_UMD|evm.model.AC_000168.1.954 Q498M4 WDR5_RAT 99.676 0.919403 1.00299 Wdr5 - WD repeat-containing protein 5 - Rattus norvegicus (Rat) - Wdr5 gene Contributes to histone modification (By similarity). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (By similarity). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (By similarity). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity). Taurus_UMD|evm.model.AC_000168.1.957 D6RBM5 U17LN_HUMAN 48.734 0.764706 1.11475 USP17L23 - Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23 - Homo sapiens (Human) - USP17L23 gene Taurus_UMD|evm.model.AC_000168.1.959 Q00975 CAC1B_HUMAN 93.468 0.567294 0.93074 CACNA1B - Voltage-dependent N-type calcium channel subunit alpha-1B - Homo sapiens (Human) - CACNA1B gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522) (By similarity). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Taurus_UMD|evm.model.AC_000168.1.960 Q9H9B1 EHMT1_HUMAN 85.703 0.992254 0.994607 EHMT1 - Histone-lysine N-methyltransferase EHMT1 - Homo sapiens (Human) - EHMT1 gene Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). Taurus_UMD|evm.model.AC_000168.1.961 Q8N5I2 ARRD1_HUMAN 86.667 0.995316 0.986143 ARRDC1 - Arrestin domain-containing protein 1 - Homo sapiens (Human) - ARRDC1 gene Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940). Taurus_UMD|evm.model.AC_000168.1.962 Q7TSV3 ZMY19_RAT 94.787 0.985915 0.938326 Zmynd19 - Zinc finger MYND domain-containing protein 19 - Rattus norvegicus (Rat) - Zmynd19 gene May be involved as a regulatory molecule in GPR24/MCH-R1 signaling. Taurus_UMD|evm.model.AC_000168.1.963 Q9BTV6 DPH7_HUMAN 65.055 0.736498 1.35177 DPH7 - Diphthine methyltransferase - Homo sapiens (Human) - DPH7 gene Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). Taurus_UMD|evm.model.AC_000168.1.964 Q5BJX1 RM41_RAT 78.519 0.985294 1.01493 Mrpl41 - 39S ribosomal protein L41, mitochondrial precursor - Rattus norvegicus (Rat) - Mrpl41 gene Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins. Taurus_UMD|evm.model.AC_000168.1.965 Q6ZV29 PLPL7_HUMAN 82.412 0.980363 1.00532 PNPLA7 - Patatin-like phospholipase domain-containing protein 7 - Homo sapiens (Human) - PNPLA7 gene Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine. Also can deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0). Taurus_UMD|evm.model.AC_000168.1.966 Q6X4W1 NSMF_HUMAN 94.400 0.954111 0.986792 NSMF - NMDA receptor synaptonuclear signaling and neuronal migration factor - Homo sapiens (Human) - NSMF gene Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. Taurus_UMD|evm.model.AC_000168.1.968 A0JND9 ENTP8_BOVIN 99.798 0.896552 1.11313 ENTPD8 - Ectonucleoside triphosphate diphosphohydrolase 8 - Bos taurus (Bovine) - ENTPD8 gene Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP (By similarity). Taurus_UMD|evm.model.AC_000168.1.969 Q86UR1 NOXA1_HUMAN 61.649 0.993684 0.997899 NOXA1 - NADPH oxidase activator 1 - Homo sapiens (Human) - NOXA1 gene Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. Taurus_UMD|evm.model.AC_000168.1.970 Q8N9H8 MUT7_HUMAN 61.423 0.713519 1.06393 EXD3 - Exonuclease mut-7 homolog - Homo sapiens (Human) - EXD3 gene Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs (By similarity). Taurus_UMD|evm.model.AC_000168.1.971 Q8N9H8 MUT7_HUMAN 62.963 0.881579 0.173516 EXD3 - Exonuclease mut-7 homolog - Homo sapiens (Human) - EXD3 gene Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs (By similarity). Taurus_UMD|evm.model.AC_000168.1.972 Q91ZA8 NRARP_MOUSE 100.000 0.29558 3.17544 Nrarp - Notch-regulated ankyrin repeat-containing protein - Mus musculus (Mouse) - Nrarp gene Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (By similarity). Involved in the regulation of canonical Wnt signaling by stabilizing LEF1 (By similarity). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (PubMed:21795391, PubMed:21998026). Taurus_UMD|evm.model.AC_000168.1.973 O42579 FZD3_XENLA 96.364 0.254717 0.319277 fzd3 - Frizzled-3 precursor - Xenopus laevis (African clawed frog) - fzd3 gene Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activated by Wnt8. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000168.1.974 Q9NXH8 TOR4A_HUMAN 77.305 0.995086 0.962175 TOR4A - Torsin-4A - Homo sapiens (Human) - TOR4A gene endoplasmic reticulum lumen, extracellular region, nuclear envelope, platelet alpha granule lumen, ATPase activity, platelet degranulation Taurus_UMD|evm.model.AC_000168.1.975 Q8WX92 NELFB_HUMAN 96.379 0.69759 1.43103 NELFB - Negative elongation factor B - Homo sapiens (Human) - NELFB gene Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). May be able to induce chromatin unfolding (PubMed:11739404). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (By similarity). Taurus_UMD|evm.model.AC_000168.1.976 Q4QR77 F166A_RAT 81.308 0.993769 1 Fam166a - Protein FAM166A - Rattus norvegicus (Rat) - Fam166a gene ciliary basal body Taurus_UMD|evm.model.AC_000168.1.977 P68372 TBB4B_MOUSE 100.000 0.995516 1.00225 Tubb4b - Tubulin beta-4B chain - Mus musculus (Mouse) - Tubb4b gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Taurus_UMD|evm.model.AC_000168.1.978 Q8N130 NPT2C_HUMAN 79.221 0.28125 0.90818 SLC34A3 - Sodium-dependent phosphate transport protein 2C - Homo sapiens (Human) - SLC34A3 gene May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx. Taurus_UMD|evm.model.AC_000168.1.979 P0DH78 RN224_HUMAN 71.739 0.872611 1.00641 RNF224 - RING finger protein 224 - Homo sapiens (Human) - RNF224 gene Taurus_UMD|evm.model.AC_000168.1.980 A0JNN6 CRTP1_BOVIN 100.000 0.984252 1.00794 CYSRT1 - Cysteine-rich tail protein 1 - Bos taurus (Bovine) - CYSRT1 gene Taurus_UMD|evm.model.AC_000168.1.981 Q8K0W3 RN208_MOUSE 89.850 0.992509 1.00755 Rnf208 - RING finger protein 208 - Mus musculus (Mouse) - Rnf208 gene cytosol, nucleoplasm, ubiquitin-protein transferase activity, protein autoubiquitination Taurus_UMD|evm.model.AC_000168.1.983 Q1JPJ0 NDOR1_BOVIN 100.000 0.996656 1.00168 NDOR1 - NADPH-dependent diflavin oxidoreductase 1 - Bos taurus (Bovine) - NDOR1 gene Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. Taurus_UMD|evm.model.AC_000168.1.984 Q8R235 TM203_MOUSE 99.265 0.985401 1.00735 Tmem203 - Transmembrane protein 203 - Mus musculus (Mouse) - Tmem203 gene Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873). Taurus_UMD|evm.model.AC_000168.1.985 A2AI08 TPRN_MOUSE 62.310 0.954839 1.03471 Tprn - Taperin - Mus musculus (Mouse) - Tprn gene stereocilium, stereocilium base, auditory receptor cell stereocilium organization, sensory perception of sound, stereocilium maintenance Taurus_UMD|evm.model.AC_000168.1.986 Q5E9C3 SSNA1_BOVIN 100.000 0.133869 6.27731 SSNA1 - Sjoegren syndrome nuclear autoantigen 1 homolog - Bos taurus (Bovine) - SSNA1 gene centrosome, ciliary basal body Taurus_UMD|evm.model.AC_000168.1.987 Q9UJX6 ANC2_HUMAN 92.632 0.984375 0.233577 ANAPC2 - Anaphase-promoting complex subunit 2 - Homo sapiens (Human) - ANAPC2 gene Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. Taurus_UMD|evm.model.AC_000168.1.988 Q9D2F0 TM210_MOUSE 74.615 0.895833 0.979592 Tmem210 - Transmembrane protein 210 precursor - Mus musculus (Mouse) - Tmem210 gene Taurus_UMD|evm.model.AC_000168.1.989 Q2I0M4 LRC26_HUMAN 76.241 0.851064 0.98503 LRRC26 - Leucine-rich repeat-containing protein 26 precursor - Homo sapiens (Human) - LRRC26 gene Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium. Taurus_UMD|evm.model.AC_000168.1.990 Q5R1P0 NMDZ1_CANLF 97.177 0.957356 0.994698 GRIN1 - Glutamate receptor ionotropic, NMDA 1 precursor - Canis lupus familiaris (Dog) - GRIN1 gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. Taurus_UMD|evm.model.AC_000168.1.992 P28700 RXRA_MOUSE 97.162 0.982796 0.995717 Rxra - Retinoic acid receptor RXR-alpha - Mus musculus (Mouse) - Rxra gene Receptor for retinoic acid that acts as a transcription factor (PubMed:10383391, PubMed:12032153, PubMed:25417649). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:1310259, PubMed:10383391). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:1310259). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:10383391, PubMed:25417649). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (By similarity). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (By similarity). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:1310259). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (By similarity). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (By similarity). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (By similarity). Acts as an enhancer of RARA binding to RARE DNA element (By similarity). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (By similarity). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (By similarity). Taurus_UMD|evm.model.AC_000168.1.993 Q9UKM7 MA1B1_HUMAN 73.242 0.983257 0.939914 MAN1B1 - Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase - Homo sapiens (Human) - MAN1B1 gene Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). Taurus_UMD|evm.model.AC_000168.1.994 Q3KQV9 UAP1L_HUMAN 84.032 0.990099 0.996055 UAP1L1 - UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 - Homo sapiens (Human) - UAP1L1 gene UDP-N-acetylglucosamine diphosphorylase activity, UDP-N-acetylglucosamine biosynthetic process Taurus_UMD|evm.model.AC_000168.1.995 Q86UD0 SAPC2_HUMAN 72.362 0.99455 0.931472 SAPCD2 - Suppressor APC domain-containing protein 2 - Homo sapiens (Human) - SAPCD2 gene Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824). Taurus_UMD|evm.model.AC_000168.1.996 G3MZR2 FUT7_BOVIN 100.000 0.367876 2.25731 FUT7 - Alpha-(1,3)-fucosyltransferase 7 - Bos taurus (Bovine) - FUT7 gene Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein or a glycolipid-linked sialopolylactosamines chain through an alpha-1,3 glycosidic linkage and participates in the final fucosylation step in the biosynthesis of the sialyl Lewis X (sLe(x)), a carbohydrate involved in cell and matrix adhesion during leukocyte trafficking and fertilization (PubMed:22909383). In vitro, also synthesizes sialyl-dimeric-Lex structures, from VIM-2 structures and both di-fucosylated and trifucosylated structures from mono-fucosylated precursors. However does not catalyze alpha 1-3 fucosylation when an internal alpha 1-3 fucosylation is present in polylactosamine chain and the fucosylation rate of the internal GlcNAc residues is reduced once fucose has been added to the distal GlcNAc. Also catalyzes the transfer of a fucose from GDP-beta-fucose to the 6-sulfated a(2,3)sialylated substrate to produce 6-sulfo sLex mediating significant L-selectin-dependent cell adhesion. Through sialyl-Lewis(x) biosynthesis, can control SELE- and SELP-mediated cell adhesion with leukocytes and allows leukocytes tethering and rolling along the endothelial tissue thereby enabling the leukocytes to accumulate at a site of inflammation. May enhance embryo implantation through sialyl Lewis X (sLeX)-mediated adhesion of embryo cells to endometrium. May affect insulin signaling by upregulating the phosphorylation and expression of some signaling molecules involved in the insulin-signaling pathway through SLe(x) which is present on the glycans of the INSRR alpha subunit (By similarity). Taurus_UMD|evm.model.AC_000168.1.997 Q9BZC7 ABCA2_HUMAN 87.202 0.855831 0.894456 ABCA2 - ATP-binding cassette sub-family A member 2 - Homo sapiens (Human) - ABCA2 gene Probable lipid tranporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (PubMed:15238223, PubMed:21810484, PubMed:24201375) (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). Taurus_UMD|evm.model.AC_000168.1.998 Q9BZC7 ABCA2_HUMAN 93.056 0.772973 0.0759754 ABCA2 - ATP-binding cassette sub-family A member 2 - Homo sapiens (Human) - ABCA2 gene Probable lipid tranporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (PubMed:15238223, PubMed:21810484, PubMed:24201375) (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). Taurus_UMD|evm.model.AC_000168.1.999 O95833 CLIC3_HUMAN 90.295 0.991597 1.00847 CLIC3 - Chloride intracellular channel protein 3 - Homo sapiens (Human) - CLIC3 gene Can insert into membranes and form chloride ion channels. May participate in cellular growth control. Taurus_UMD|evm.model.AC_000168.1.1000 Q9BUH6 PAXX_HUMAN 87.000 0.970732 1.0049 PAXX - Protein PAXX - Homo sapiens (Human) - PAXX gene Involved in non-homologous end joining (NHEJ), a major pathway to repair double-strand breaks in DNA. May act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery. Taurus_UMD|evm.model.AC_000168.1.1001 Q6ZST4 LCNL1_HUMAN 67.961 0.554348 1.12195 LCNL1 - Lipocalin-like 1 protein - Homo sapiens (Human) - LCNL1 gene Taurus_UMD|evm.model.AC_000168.1.1002 O02853 PTGDS_BOVIN 100.000 0.989583 1.00524 PTGDS - Prostaglandin-H2 D-isomerase precursor - Bos taurus (Bovine) - PTGDS gene Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation (PubMed:9510973). Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). Taurus_UMD|evm.model.AC_000168.1.1003 Q6JVE5 LCN12_HUMAN 52.778 0.598662 1.55729 LCN12 - Epididymal-specific lipocalin-12 precursor - Homo sapiens (Human) - LCN12 gene Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity). Taurus_UMD|evm.model.AC_000168.1.1004 P07360 CO8G_HUMAN 81.188 0.990148 1.00495 C8G - Complement component C8 gamma chain precursor - Homo sapiens (Human) - C8G gene C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Taurus_UMD|evm.model.AC_000168.1.1006 Q969U6 FBXW5_HUMAN 90.265 0.9947 1 FBXW5 - F-box/WD repeat-containing protein 5 - Homo sapiens (Human) - FBXW5 gene Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Taurus_UMD|evm.model.AC_000168.1.1007 Q12933 TRAF2_HUMAN 86.047 0.748547 1.37325 TRAF2 - TNF receptor-associated factor 2 - Homo sapiens (Human) - TRAF2 gene Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. Taurus_UMD|evm.model.AC_000168.1.1008 O60869 EDF1_HUMAN 100.000 0.986577 1.00676 EDF1 - Endothelial differentiation-related factor 1 - Homo sapiens (Human) - EDF1 gene Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. Taurus_UMD|evm.model.AC_000168.1.1009 Q6UXC1 AEGP_HUMAN 75.882 0.997527 0.997533 MAMDC4 - Apical endosomal glycoprotein precursor - Homo sapiens (Human) - MAMDC4 gene Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. Taurus_UMD|evm.model.AC_000168.1.1010 Q32PA4 PHP14_BOVIN 100.000 0.984127 1.008 PHPT1 - 14 kDa phosphohistidine phosphatase - Bos taurus (Bovine) - PHPT1 gene Exhibits phosphohistidine phosphatase activity. Taurus_UMD|evm.model.AC_000168.1.1011 C9J069 AJM1_HUMAN 88.627 0.866548 1.15164 AJM1 - Apical junction component 1 homolog - Homo sapiens (Human) - AJM1 gene May be involved in the control of adherens junction integrity. Taurus_UMD|evm.model.AC_000168.1.1012 Q08DA0 RABL6_BOVIN 100.000 0.997151 1.00143 RABL6 - Rab-like protein 6 - Bos taurus (Bovine) - RABL6 gene May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A (By similarity). Taurus_UMD|evm.model.AC_000168.1.1014 A2AJB1 CC183_MOUSE 78.394 0.975701 1.00187 Ccdc183 - Coiled-coil domain-containing protein 183 - Mus musculus (Mouse) - Ccdc183 gene Taurus_UMD|evm.model.AC_000168.1.1015 Q3SZU9 TM141_BOVIN 100.000 0.981651 1.00926 TMEM141 - Transmembrane protein 141 - Bos taurus (Bovine) - TMEM141 gene Taurus_UMD|evm.model.AC_000168.1.1016 Q6UWW0 LCN15_HUMAN 76.879 0.291525 3.20652 LCN15 - Lipocalin-15 precursor - Homo sapiens (Human) - LCN15 gene Taurus_UMD|evm.model.AC_000168.1.1017 P62503 LCN6_MACMU 65.244 0.79902 1.13333 LCN6 - Epididymal-specific lipocalin-6 precursor - Macaca mulatta (Rhesus macaque) - LCN6 gene May play a role in male fertility. Taurus_UMD|evm.model.AC_000168.1.1018 Q810Z1 LCN10_MOUSE 55.114 0.94086 1.02198 Lcn10 - Epididymal-specific lipocalin-10 precursor - Mus musculus (Mouse) - Lcn10 gene May play a role in male fertility. May act as a retinoid carrier protein within the epididymis. Taurus_UMD|evm.model.AC_000168.1.1019 P53715 LCN1_PIG 58.282 0.931034 0.988636 LCN1 - Lipocalin-1 precursor - Sus scrofa (Pig) - LCN1 gene Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket (By similarity). Taurus_UMD|evm.model.AC_000168.1.1020 Q9NPH6 OBP2B_HUMAN 40.606 0.758294 1.24118 OBP2B - Odorant-binding protein 2b precursor - Homo sapiens (Human) - OBP2B gene Probably binds and transports small hydrophobic volatile molecules. Taurus_UMD|evm.model.AC_000168.1.1021 P82923 RT02_BOVIN 100.000 0.993197 1.00341 MRPS2 - 28S ribosomal protein S2, mitochondrial - Bos taurus (Bovine) - MRPS2 gene Required for mitoribosome formation and stability, and mitochondrial translation. Taurus_UMD|evm.model.AC_000168.1.1022 Q32P67 CI116_BOVIN 100.000 0.985401 1.00735 UPF0691 protein C9orf116 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000168.1.1023 Q5T8A7 PPR26_HUMAN 52.522 0.992334 0.97105 PPP1R26 - Protein phosphatase 1 regulatory subunit 26 - Homo sapiens (Human) - PPP1R26 gene Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation. Taurus_UMD|evm.model.AC_000168.1.1027 Q62609 NOE1_RAT 97.941 0.951965 0.94433 Olfm1 - Noelin precursor - Rattus norvegicus (Rat) - Olfm1 gene Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity). Taurus_UMD|evm.model.AC_000168.1.1030 Q5I2E5 FCN2_BOVIN 100.000 0.993939 1.00304 FCN2 - Ficolin-2 precursor - Bos taurus (Bovine) - FCN2 gene May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity). Taurus_UMD|evm.model.AC_000168.1.1032 P20908 CO5A1_HUMAN 95.344 0.643183 0.834059 COL5A1 - Collagen alpha-1(V) chain precursor - Homo sapiens (Human) - COL5A1 gene Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Taurus_UMD|evm.model.AC_000168.1.1034 P20908 CO5A1_HUMAN 96.154 0.79386 0.124048 COL5A1 - Collagen alpha-1(V) chain precursor - Homo sapiens (Human) - COL5A1 gene Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Taurus_UMD|evm.model.AC_000168.1.1039 P13164 IFM1_HUMAN 70.370 0.571429 1.12 IFITM1 - Interferon-induced transmembrane protein 1 - Homo sapiens (Human) - IFITM1 gene IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) (PubMed:26354436, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration (PubMed:33270927). Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). Taurus_UMD|evm.model.AC_000168.1.1040 Q3SYY2 TPST2_BOVIN 55.039 0.524444 0.596817 TPST2 - Protein-tyrosine sulfotransferase 2 - Bos taurus (Bovine) - TPST2 gene Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. Taurus_UMD|evm.model.AC_000168.1.1041 Q8TD33 SG1C1_HUMAN 77.895 0.979167 1.01053 SCGB1C1 - Secretoglobin family 1C member 1 precursor - Homo sapiens (Human) - SCGB1C1 gene Taurus_UMD|evm.model.AC_000168.1.1042 Q2TBH0 ODF3A_BOVIN 99.606 0.992157 1.00394 ODF3 - Outer dense fiber protein 3 - Bos taurus (Bovine) - ODF3 gene Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail. Taurus_UMD|evm.model.AC_000168.1.1043 Q3MHP8 BET1L_BOVIN 100.000 0.982143 1.00901 BET1L - BET1-like protein - Bos taurus (Bovine) - BET1L gene Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity). Taurus_UMD|evm.model.AC_000168.1.1044 Q5E9J8 RIC8A_BOVIN 100.000 0.996234 1.00189 RIC8A - Synembryn-A - Bos taurus (Bovine) - RIC8A gene Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity). Taurus_UMD|evm.model.AC_000168.1.1045 Q9NTG7 SIR3_HUMAN 75.988 0.979042 0.837093 SIRT3 - NAD-dependent protein deacetylase sirtuin-3, mitochondrial precursor - Homo sapiens (Human) - SIRT3 gene NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity). Taurus_UMD|evm.model.AC_000168.1.1046 Q32M88 PGGHG_HUMAN 82.138 0.730975 1.26594 PGGHG - Protein-glucosylgalactosylhydroxylysine glucosidase - Homo sapiens (Human) - PGGHG gene Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins. Taurus_UMD|evm.model.AC_000168.1.1047 P59044 NLRP6_HUMAN 72.924 0.976244 0.991031 NLRP6 - NACHT, LRR and PYD domains-containing protein 6 - Homo sapiens (Human) - NLRP6 gene As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity) (PubMed:12387869). Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity). Taurus_UMD|evm.model.AC_000168.1.1048 P10175 COX8B_BOVIN 97.143 0.971831 1.01429 COX8B - Cytochrome c oxidase subunit 8B, mitochondrial precursor - Bos taurus (Bovine) - COX8B gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000168.1.1049 Q5E964 PSD13_BOVIN 100.000 0.944079 0.808511 PSMD13 - 26S proteasome non-ATPase regulatory subunit 13 - Bos taurus (Bovine) - PSMD13 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Taurus_UMD|evm.model.AC_000168.1.1050 P13164 IFM1_HUMAN 74.510 0.316614 2.552 IFITM1 - Interferon-induced transmembrane protein 1 - Homo sapiens (Human) - IFITM1 gene IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) (PubMed:26354436, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration (PubMed:33270927). Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). Taurus_UMD|evm.model.AC_000169.1.1 Q8N6Y1 PCD20_HUMAN 90.231 0.997899 1.00105 PCDH20 - Protocadherin-20 precursor - Homo sapiens (Human) - PCDH20 gene Potential calcium-dependent cell-adhesion protein. Taurus_UMD|evm.model.AC_000169.1.2 P68105 EF1A1_RABIT 94.156 0.993363 0.978355 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000169.1.4 Q63610 TPM3_RAT 94.375 0.969512 0.66129 Tpm3 - Tropomyosin alpha-3 chain - Rattus norvegicus (Rat) - Tpm3 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Taurus_UMD|evm.model.AC_000169.1.5 Q2HJG4 TDRD3_BOVIN 84.812 0.996951 0.908587 TDRD3 - Tudor domain-containing protein 3 - Bos taurus (Bovine) - TDRD3 gene Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins (By similarity). Taurus_UMD|evm.model.AC_000169.1.6 Q14694 UBP10_HUMAN 56.440 0.652591 0.652882 USP10 - Ubiquitin carboxyl-terminal hydrolase 10 - Homo sapiens (Human) - USP10 gene Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Taurus_UMD|evm.model.AC_000169.1.7 P39872 RL3_BOVIN 71.264 0.934783 0.228288 RPL3 - 60S ribosomal protein L3 - Bos taurus (Bovine) - RPL3 gene The L3 protein is a component of the large subunit of cytoplasmic ribosomes. Taurus_UMD|evm.model.AC_000169.1.8 Q9NSV4 DIAP3_HUMAN 86.713 0.484979 0.97653 DIAPH3 - Protein diaphanous homolog 3 - Homo sapiens (Human) - DIAPH3 gene Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. Taurus_UMD|evm.model.AC_000169.1.9 Q3ZBP8 CO040_BOVIN 88.158 0.862069 0.690476 UPF0235 protein C15orf40 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000169.1.10 O14917 PCD17_HUMAN 98.105 0.998279 1.00259 PCDH17 - Protocadherin-17 precursor - Homo sapiens (Human) - PCDH17 gene Potential calcium-dependent cell-adhesion protein. Taurus_UMD|evm.model.AC_000169.1.12 Q86W50 MET16_HUMAN 73.077 0.980769 0.0925267 METTL16 - RNA N6-adenosine-methyltransferase METTL16 - Homo sapiens (Human) - METTL16 gene RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197299, PubMed:30197297). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197299, PubMed:30197297). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing and/or stability of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression (PubMed:28525753). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). Taurus_UMD|evm.model.AC_000169.1.13 Q920A7 AFG31_MOUSE 71.512 0.981928 0.210393 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Taurus_UMD|evm.model.AC_000169.1.14 Q4R5G2 TCPA_MACFA 65.000 0.988636 0.158273 TCP1 - T-complex protein 1 subunit alpha - Macaca fascicularis (Crab-eating macaque) - TCP1 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Taurus_UMD|evm.model.AC_000169.1.16 Q9HD36 B2L10_HUMAN 61.111 0.972603 0.357843 BCL2L10 - Bcl-2-like protein 10 - Homo sapiens (Human) - BCL2L10 gene Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (PubMed:11689480, PubMed:11278245). Increases binding of AHCYL1/IRBIT to ITPR1 (PubMed:27995898). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (PubMed:27995898). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). Taurus_UMD|evm.model.AC_000169.1.17 P0DP42 T225B_HUMAN 72.637 0.803213 1.1267 TMEM225B - Transmembrane protein 225B - Homo sapiens (Human) - TMEM225B gene Taurus_UMD|evm.model.AC_000169.1.19 Q9ER69 FL2D_MOUSE 89.899 0.989848 0.497475 Wtap - Pre-mRNA-splicing regulator WTAP - Mus musculus (Mouse) - Wtap gene Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189, PubMed:29547716). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (PubMed:29547716). Required for accumulation of METTL3 and METTL14 to nuclear speckle (By similarity). Acts as a mRNA splicing regulator (By similarity). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (By similarity). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (By similarity). Taurus_UMD|evm.model.AC_000169.1.20 Q9ER69 FL2D_MOUSE 96.800 0.873239 0.358586 Wtap - Pre-mRNA-splicing regulator WTAP - Mus musculus (Mouse) - Wtap gene Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189, PubMed:29547716). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (PubMed:29547716). Required for accumulation of METTL3 and METTL14 to nuclear speckle (By similarity). Acts as a mRNA splicing regulator (By similarity). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (By similarity). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (By similarity). Taurus_UMD|evm.model.AC_000169.1.25 O95206 PCDH8_HUMAN 73.369 0.775 0.598131 PCDH8 - Protocadherin-8 precursor - Homo sapiens (Human) - PCDH8 gene Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity). Taurus_UMD|evm.model.AC_000169.1.26 Q6UX06 OLFM4_HUMAN 78.104 0.876248 0.982353 OLFM4 - Olfactomedin-4 precursor - Homo sapiens (Human) - OLFM4 gene May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. Taurus_UMD|evm.model.AC_000169.1.27 O95206 PCDH8_HUMAN 94.030 0.998133 1.00093 PCDH8 - Protocadherin-8 precursor - Homo sapiens (Human) - PCDH8 gene Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity). Taurus_UMD|evm.model.AC_000169.1.28 P17404 CNMD_BOVIN 100.000 0.92011 1.08358 CNMD - Leukocyte cell-derived chemotaxin 1 precursor - Bos taurus (Bovine) - CNMD gene Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity). Taurus_UMD|evm.model.AC_000169.1.29 Q2KIK0 SGT1_BOVIN 99.704 0.994083 1 SUGT1 - Protein SGT1 homolog - Bos taurus (Bovine) - SUGT1 gene May play a role in ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000169.1.30 A0JN51 ELF1_BOVIN 100.000 0.996748 1.00163 ELF1 - ETS-related transcription factor Elf-1 - Bos taurus (Bovine) - ELF1 gene Transcription factor that activates the LYN and BLK promoters. Taurus_UMD|evm.model.AC_000169.1.31 Q4R7Y2 RL10_MACFA 80.645 0.521368 0.546729 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000169.1.32 O75554 WBP4_HUMAN 76.471 0.969605 0.875 WBP4 - WW domain-binding protein 4 - Homo sapiens (Human) - WBP4 gene Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:9724750, PubMed:19592703, PubMed:28781166). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). Taurus_UMD|evm.model.AC_000169.1.33 Q86V97 KBTB6_HUMAN 85.390 0.997167 1.04748 KBTBD6 - Kelch repeat and BTB domain-containing protein 6 - Homo sapiens (Human) - KBTBD6 gene As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205). Taurus_UMD|evm.model.AC_000169.1.34 Q4R4R6 CDC42_MACFA 44.231 0.780822 0.382199 CDC42 - Cell division control protein 42 homolog precursor - Macaca fascicularis (Crab-eating macaque) - CDC42 gene Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (By similarity). Taurus_UMD|evm.model.AC_000169.1.36 Q8WVZ9 KBTB7_HUMAN 95.906 0.997063 0.995614 KBTBD7 - Kelch repeat and BTB domain-containing protein 7 - Homo sapiens (Human) - KBTBD7 gene As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205). Taurus_UMD|evm.model.AC_000169.1.37 Q3MHI7 RF1M_BOVIN 100.000 0.995536 1.00224 MTRF1 - Peptide chain release factor 1, mitochondrial precursor - Bos taurus (Bovine) - MTRF1 gene Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA. Taurus_UMD|evm.model.AC_000169.1.38 Q6N069 NAA16_HUMAN 91.194 0.996471 0.983796 NAA16 - N-alpha-acetyltransferase 16, NatA auxiliary subunit - Homo sapiens (Human) - NAA16 gene Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Taurus_UMD|evm.model.AC_000169.1.39 Q9H4X1 RGCC_HUMAN 89.189 0.797101 1.0073 RGCC - Regulator of cell cycle RGCC - Homo sapiens (Human) - RGCC gene Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. Taurus_UMD|evm.model.AC_000169.1.40 A3KMH1 VWA8_HUMAN 91.617 0.849548 0.928084 VWA8 - von Willebrand factor A domain-containing protein 8 precursor - Homo sapiens (Human) - VWA8 gene Exhibits ATPase activity in vitro. Taurus_UMD|evm.model.AC_000169.1.41 Q86XP1 DGKH_HUMAN 93.450 0.998152 0.886885 DGKH - Diacylglycerol kinase eta - Homo sapiens (Human) - DGKH gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016). Taurus_UMD|evm.model.AC_000169.1.42 Q9UKA4 AKA11_HUMAN 78.743 0.998951 1.00263 AKAP11 - A-kinase anchor protein 11 - Homo sapiens (Human) - AKAP11 gene Binds to type II regulatory subunits of protein kinase A and anchors/targets them. Taurus_UMD|evm.model.AC_000169.1.43 O14788 TNF11_HUMAN 85.174 0.993399 0.955836 TNFSF11 - Tumor necrosis factor ligand superfamily member 11 - Homo sapiens (Human) - TNFSF11 gene Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity). Taurus_UMD|evm.model.AC_000169.1.44 Q17QP0 F216B_BOVIN 100.000 0.8 1.24138 FAM216B - Protein FAM216B - Bos taurus (Bovine) - FAM216B gene Taurus_UMD|evm.model.AC_000169.1.45 Q96J88 ESIP1_HUMAN 55.063 0.985401 0.861635 EPSTI1 - Epithelial-stromal interaction protein 1 - Homo sapiens (Human) - EPSTI1 gene Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity). Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (By similarity). Taurus_UMD|evm.model.AC_000169.1.46 Q9Y5T4 DJC15_HUMAN 80.667 0.986667 1 DNAJC15 - DnaJ homolog subfamily C member 15 - Homo sapiens (Human) - DNAJC15 gene Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. Taurus_UMD|evm.model.AC_000169.1.47 Q8TC92 ENOX1_HUMAN 99.109 0.996441 0.874028 ENOX1 - Ecto-NOX disulfide-thiol exchanger 1 - Homo sapiens (Human) - ENOX1 gene Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock. Taurus_UMD|evm.model.AC_000169.1.49 Q5T0U0 CC122_HUMAN 68.727 0.991525 0.864469 CCDC122 - Coiled-coil domain-containing protein 122 - Homo sapiens (Human) - CCDC122 gene Taurus_UMD|evm.model.AC_000169.1.50 Q8IV20 LACC1_HUMAN 85.116 0.995316 0.993023 LACC1 - Purine nucleoside phosphorylase LACC1 - Homo sapiens (Human) - LACC1 gene Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine (PubMed:31978345). Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (PubMed:31978345). Also has adenosine deaminase activity (PubMed:31978345). Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages (PubMed:31978345). Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface (PubMed:31978345). The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity (PubMed:31978345). Participates in pattern recognition receptor (PRR)-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance (PubMed:28593945, PubMed:31875558). Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR) (PubMed:31875558). Does not show laccase activity (PubMed:27959965, PubMed:31978345). Taurus_UMD|evm.model.AC_000169.1.52 Q9EQ60 CAC1H_RAT 61.957 0.514793 0.0716405 Cacna1h - Voltage-dependent T-type calcium channel subunit alpha-1H - Rattus norvegicus (Rat) - Cacna1h gene Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:11073957). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (By similarity). Taurus_UMD|evm.model.AC_000169.1.53 Q6TAW2 SERP2_MOUSE 77.778 0.344156 2.36923 Serp2 - Stress-associated endoplasmic reticulum protein 2 - Mus musculus (Mouse) - Serp2 gene May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential). Taurus_UMD|evm.model.AC_000169.1.54 Q4R4H5 T22D1_MACFA 100.000 0.986207 1.00694 TSC22D1 - TSC22 domain family protein 1 - Macaca fascicularis (Crab-eating macaque) - TSC22D1 gene Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter (By similarity). Taurus_UMD|evm.model.AC_000169.1.55 Q5R4H1 T22D1_PONAB 80.894 0.996904 0.905607 TSC22D1 - TSC22 domain family protein 1 - Pongo abelii (Sumatran orangutan) - TSC22D1 gene Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter (By similarity). Taurus_UMD|evm.model.AC_000169.1.57 Q9UHK0 NUFP1_HUMAN 71.515 0.993724 0.965657 NUFIP1 - Nuclear fragile X mental retardation-interacting protein 1 - Homo sapiens (Human) - NUFIP1 gene Binds RNA. Taurus_UMD|evm.model.AC_000169.1.58 Q3ZBM6 GPAM1_BOVIN 100.000 0.623077 1.40794 GPALPP1 - GPALPP motifs-containing protein 1 - Bos taurus (Bovine) - GPALPP1 gene Taurus_UMD|evm.model.AC_000169.1.59 Q3SYV4 CAP1_BOVIN 97.040 0.995763 1 CAP1 - Adenylyl cyclase-associated protein 1 - Bos taurus (Bovine) - CAP1 gene Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. Taurus_UMD|evm.model.AC_000169.1.60 Q2T9L9 T2FB_BOVIN 100.000 0.992 1.00402 GTF2F2 - General transcription factor IIF subunit 2 - Bos taurus (Bovine) - GTF2F2 gene TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity (By similarity). Taurus_UMD|evm.model.AC_000169.1.61 Q5E984 TCTP_BOVIN 100.000 0.777273 1.27907 TPT1 - Translationally-controlled tumor protein - Bos taurus (Bovine) - TPT1 gene Involved in calcium binding and microtubule stabilization. Taurus_UMD|evm.model.AC_000169.1.62 Q8HXE3 KMCP1_MACFA 95.533 0.826211 1.20619 SLC25A30 - Kidney mitochondrial carrier protein 1 - Macaca fascicularis (Crab-eating macaque) - SLC25A30 gene Probable transporter. Taurus_UMD|evm.model.AC_000169.1.63 Q96JB2 COG3_HUMAN 91.411 0.978049 0.990338 COG3 - Conserved oligomeric Golgi complex subunit 3 - Homo sapiens (Human) - COG3 gene Involved in ER-Golgi transport. Taurus_UMD|evm.model.AC_000169.1.64 Q5W0A0 ERI6B_HUMAN 52.535 0.817391 0.826149 ERICH6B - Glutamate-rich protein 6B - Homo sapiens (Human) - ERICH6B gene Taurus_UMD|evm.model.AC_000169.1.65 A6QQS3 CBY2_BOVIN 100.000 0.995614 1.0022 CBY2 - Protein chibby homolog 2 - Bos taurus (Bovine) - CBY2 gene Taurus_UMD|evm.model.AC_000169.1.66 Q8IW03 SIAH3_HUMAN 77.246 0.648221 0.94052 SIAH3 - Seven in absentia homolog 3 - Homo sapiens (Human) - SIAH3 gene Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria. Taurus_UMD|evm.model.AC_000169.1.67 Q5T200 ZC3HD_HUMAN 95.399 0.393829 0.991007 ZC3H13 - Zinc finger CCCH domain-containing protein 13 - Homo sapiens (Human) - ZC3H13 gene Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). Taurus_UMD|evm.model.AC_000169.1.68 Q2KIG3 CBPB2_BOVIN 100.000 0.995283 1.00236 CPB2 - Carboxypeptidase B2 precursor - Bos taurus (Bovine) - CPB2 gene Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. Taurus_UMD|evm.model.AC_000169.1.69 Q61233 PLSL_MOUSE 96.491 0.996815 1.00159 Lcp1 - Plastin-2 - Mus musculus (Mouse) - Lcp1 gene Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Taurus_UMD|evm.model.AC_000169.1.70 Q05C16 LRC63_HUMAN 60.000 0.729447 1.15345 LRRC63 - Leucine-rich repeat-containing protein 63 - Homo sapiens (Human) - LRRC63 gene Taurus_UMD|evm.model.AC_000169.1.71 A7E316 PACER_BOVIN 100.000 0.996988 1.00151 RUBCNL - Protein associated with UVRAG as autophagy enhancer - Bos taurus (Bovine) - RUBCNL gene Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex. Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes. Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (By similarity). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (By similarity). Taurus_UMD|evm.model.AC_000169.1.72 Q9Y2L9 LRCH1_HUMAN 86.043 0.890746 1.06868 LRCH1 - Leucine-rich repeat and calponin homology domain-containing protein 1 - Homo sapiens (Human) - LRCH1 gene Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration. Taurus_UMD|evm.model.AC_000169.1.73 Q08E20 ESTD_BOVIN 100.000 0.959044 1.03901 ESD - S-formylglutathione hydrolase - Bos taurus (Bovine) - ESD gene Serine hydrolase involved in the detoxification of formaldehyde. Taurus_UMD|evm.model.AC_000169.1.74 Q75Z89 5HT2A_BOVIN 100.000 0.995754 1.00213 HTR2A - 5-hydroxytryptamine receptor 2A - Bos taurus (Bovine) - HTR2A gene G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity). Taurus_UMD|evm.model.AC_000169.1.75 O00370 LORF2_HUMAN 63.855 0.942529 0.0682353 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000169.1.76 Q148D5 SUCB1_BOVIN 99.784 0.99569 1.00216 SUCLA2 - Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial precursor - Bos taurus (Bovine) - SUCLA2 gene ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Taurus_UMD|evm.model.AC_000169.1.77 Q9NV35 NUD15_HUMAN 93.902 0.947674 1.04878 NUDT15 - Nucleotide triphosphate diphosphatase NUDT15 - Homo sapiens (Human) - NUDT15 gene May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PubMed:26238318, PubMed:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956). Taurus_UMD|evm.model.AC_000169.1.78 Q3SYZ9 MED4_BOVIN 100.000 0.99262 1.0037 MED4 - Mediator of RNA polymerase II transcription subunit 4 - Bos taurus (Bovine) - MED4 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Taurus_UMD|evm.model.AC_000169.1.79 A5A6H4 ROA1_PANTR 95.238 0.639456 0.91875 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Pan troglodytes (Chimpanzee) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. Taurus_UMD|evm.model.AC_000169.1.80 Q3T0P7 ITM2B_BOVIN 99.624 0.992509 1.00376 ITM2B - Integral membrane protein 2B - Bos taurus (Bovine) - ITM2B gene Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity). Taurus_UMD|evm.model.AC_000169.1.81 P62919 RL8_RAT 96.109 0.992248 1.00389 Rpl8 - 60S ribosomal protein L8 - Rattus norvegicus (Rat) - Rpl8 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000169.1.82 P06400 RB_HUMAN 93.534 0.997847 1.00108 RB1 - Retinoblastoma-associated protein - Homo sapiens (Human) - RB1 gene Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). Taurus_UMD|evm.model.AC_000169.1.83 Q5RCZ7 RCBT2_PONAB 96.015 0.996212 0.958258 RCBTB2 - RCC1 and BTB domain-containing protein 2 - Pongo abelii (Sumatran orangutan) - RCBTB2 gene Taurus_UMD|evm.model.AC_000169.1.85 Q95N03 CLTR2_PIG 83.140 0.991329 1.0029 CYSLTR2 - Cysteinyl leukotriene receptor 2 - Sus scrofa (Pig) - CYSLTR2 gene Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). Taurus_UMD|evm.model.AC_000169.1.86 Q62280 SSXT_MOUSE 59.259 0.622951 0.291866 Ss18 - Protein SSXT - Mus musculus (Mouse) - Ss18 gene Appears to function synergistically with RBM14 as a transcriptional coactivator. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Taurus_UMD|evm.model.AC_000169.1.87 Q9Y2H6 FND3A_HUMAN 94.240 0.998332 1.00083 FNDC3A - Fibronectin type-III domain-containing protein 3A - Homo sapiens (Human) - FNDC3A gene Mediates spermatid-Sertoli adhesion during spermatogenesis. Taurus_UMD|evm.model.AC_000169.1.88 O43193 MTLR_HUMAN 81.463 0.954762 1.01942 MLNR - Motilin receptor - Homo sapiens (Human) - MLNR gene Receptor for motilin. Taurus_UMD|evm.model.AC_000169.1.89 Q4R683 CDAC1_MACFA 91.456 0.996124 1.00194 CDADC1 - Cytidine and dCMP deaminase domain-containing protein 1 - Macaca fascicularis (Crab-eating macaque) - CDADC1 gene Catalyzes the deamination of cytidine and deoxycytidine into uridine and deoxyuridine, respectively. May play an important role in testicular development and spermatogenesis. Taurus_UMD|evm.model.AC_000169.1.90 Q9H9S4 CB39L_HUMAN 95.536 0.943662 1.05341 CAB39L - Calcium-binding protein 39-like - Homo sapiens (Human) - CAB39L gene Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity). Taurus_UMD|evm.model.AC_000169.1.92 Q96T68 SETB2_HUMAN 77.330 0.997147 0.974965 SETDB2 - Histone-lysine N-methyltransferase SETDB2 - Homo sapiens (Human) - SETDB2 gene Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. Taurus_UMD|evm.model.AC_000169.1.93 Q2HJ93 PHF11_BOVIN 100.000 0.994083 1.00297 PHF11 - PHD finger protein 11 - Bos taurus (Bovine) - PHF11 gene Positive regulator of Th1-type cytokine gene expression. Taurus_UMD|evm.model.AC_000169.1.94 Q8NDN9 RCBT1_HUMAN 97.175 0.757143 1.31827 RCBTB1 - RCC1 and BTB domain-containing protein 1 - Homo sapiens (Human) - RCBTB1 gene May be involved in cell cycle regulation by chromatin remodeling. Taurus_UMD|evm.model.AC_000169.1.95 Q0VCI6 PIHD1_BOVIN 95.536 0.649123 0.589655 PIH1D1 - PIH1 domain-containing protein 1 - Bos taurus (Bovine) - PIH1D1 gene Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (By similarity). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity). Positively regulates the assembly and activity of the mTORC1 complex (By similarity). Taurus_UMD|evm.model.AC_000169.1.96 Q58DI9 ARL11_BOVIN 80.925 0.843137 1.12088 ARL11 - ADP-ribosylation factor-like protein 11 - Bos taurus (Bovine) - ARL11 gene May play a role in apoptosis. May act as a tumor suppressor (By similarity). Taurus_UMD|evm.model.AC_000169.1.97 Q9BY08 EBPL_HUMAN 71.845 0.989189 0.898058 EBPL - Emopamil-binding protein-like - Homo sapiens (Human) - EBPL gene Does not possess sterol isomerase activity and does not bind sigma ligands. Taurus_UMD|evm.model.AC_000169.1.98 O35344 IMA4_MOUSE 100.000 0.995984 0.955854 Kpna3 - Importin subunit alpha-4 - Mus musculus (Mouse) - Kpna3 gene Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Taurus_UMD|evm.model.AC_000169.1.99 Q2T9X3 SPRY7_BOVIN 100.000 0.989848 1.0051 SPRYD7 - SPRY domain-containing protein 7 - Bos taurus (Bovine) - SPRYD7 gene Taurus_UMD|evm.model.AC_000169.1.101 Q32L60 TRI13_BOVIN 100.000 0.995098 1.00246 TRIM13 - E3 ubiquitin-protein ligase TRIM13 - Bos taurus (Bovine) - TRIM13 gene Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Plays also a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation. Participates as well in T-cell receptor-mediated NF-kappa-B activation. In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B. Taurus_UMD|evm.model.AC_000169.1.102 Q863D4 KCNRG_BOVIN 100.000 0.992537 1.00375 KCNRG - Potassium channel regulatory protein - Bos taurus (Bovine) - KCNRG gene Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes (By similarity). Taurus_UMD|evm.model.AC_000169.1.103 Q3ZBI3 RNH2B_BOVIN 99.029 0.993485 0.993528 RNASEH2B - Ribonuclease H2 subunit B - Bos taurus (Bovine) - RNASEH2B gene Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity). Taurus_UMD|evm.model.AC_000169.1.104 O75343 GCYB2_HUMAN 82.432 0.757692 1.26418 GUCY1B2 - Guanylate cyclase soluble subunit beta-2 - Homo sapiens (Human) - GUCY1B2 gene cGMP-mediated signaling Taurus_UMD|evm.model.AC_000169.1.106 A0A1B0GVH6 CM042_HUMAN 79.421 0.993443 0.938462 C13orf42 - Uncharacterized protein C13orf42 - Homo sapiens (Human) - C13orf42 gene Taurus_UMD|evm.model.AC_000169.1.107 Q5RA50 F124A_PONAB 76.923 0.99633 0.998168 FAM124A - Protein FAM124A - Pongo abelii (Sumatran orangutan) - FAM124A gene Taurus_UMD|evm.model.AC_000169.1.108 A6QQ92 SERP3_BOVIN 100.000 0.819533 1.1775 SERPINE3 - Serpin E3 precursor - Bos taurus (Bovine) - SERPINE3 gene Probable serine protease inhibitor. Taurus_UMD|evm.model.AC_000169.1.109 Q9UL03 INT6_HUMAN 97.718 0.897467 0.934611 INTS6 - Integrator complex subunit 6 - Homo sapiens (Human) - INTS6 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144). Taurus_UMD|evm.model.AC_000169.1.110 Q96P53 WDFY2_HUMAN 98.250 0.995012 1.0025 WDFY2 - WD repeat and FYVE domain-containing protein 2 - Homo sapiens (Human) - WDFY2 gene Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553). Taurus_UMD|evm.model.AC_000169.1.111 A6QP05 DHR12_BOVIN 100.000 0.993711 1.00315 DHRS12 - Dehydrogenase/reductase SDR family member 12 - Bos taurus (Bovine) - DHRS12 gene Putative oxidoreductase. Taurus_UMD|evm.model.AC_000169.1.112 Q0II65 CCD70_BOVIN 100.000 0.991031 1.0045 CCDC70 - Coiled-coil domain-containing protein 70 precursor - Bos taurus (Bovine) - CCDC70 gene Taurus_UMD|evm.model.AC_000169.1.113 Q9XT50 ATP7B_SHEEP 95.953 0.991003 0.960133 ATP7B - Copper-transporting ATPase 2 - Ovis aries (Sheep) - ATP7B gene Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile. Taurus_UMD|evm.model.AC_000169.1.114 Q2TAA5 ALG11_HUMAN 89.634 0.982 1.01626 ALG11 - GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase - Homo sapiens (Human) - ALG11 gene Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain. Taurus_UMD|evm.model.AC_000169.1.115 Q7TSC3 NEK5_MOUSE 78.598 0.332512 1.29506 Nek5 - Serine/threonine-protein kinase Nek5 - Mus musculus (Mouse) - Nek5 gene protein kinase activity, positive regulation of cysteine-type endopeptidase activity, positive regulation of striated muscle cell differentiation Taurus_UMD|evm.model.AC_000169.1.116 P51956 NEK3_HUMAN 83.960 0.993952 0.980237 NEK3 - Serine/threonine-protein kinase Nek3 - Homo sapiens (Human) - NEK3 gene Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. Taurus_UMD|evm.model.AC_000169.1.117 A5D7U0 CKAP2_BOVIN 87.977 0.997072 1.0928 CKAP2 - Cytoskeleton-associated protein 2 - Bos taurus (Bovine) - CKAP2 gene Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000169.1.118 A5PK00 VPS36_BOVIN 99.741 0.994832 1.00259 VPS36 - Vacuolar protein-sorting-associated protein 36 - Bos taurus (Bovine) - VPS36 gene Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. Taurus_UMD|evm.model.AC_000169.1.119 Q5BIR3 THSD1_BOVIN 99.882 0.997647 1.00118 THSD1 - Thrombospondin type-1 domain-containing protein 1 precursor - Bos taurus (Bovine) - THSD1 gene Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix. Taurus_UMD|evm.model.AC_000169.1.120 Q6XPS3 TPTE2_HUMAN 63.450 0.787682 1.18199 TPTE2 - Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 - Homo sapiens (Human) - TPTE2 gene Acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. Taurus_UMD|evm.model.AC_000169.1.121 Q9Y619 ORNT1_HUMAN 95.349 0.993377 1.00332 SLC25A15 - Mitochondrial ornithine transporter 1 - Homo sapiens (Human) - SLC25A15 gene Ornithine-citrulline antiporter. Connects the cytosolic and the intramitochondrial reactions of the urea cycle by exchanging cytosolic ornithine with matrix citrulline (PubMed:12807890). The stoichiometry is close to 1:1 (By similarity). Taurus_UMD|evm.model.AC_000169.1.123 Q86VY4 TSYL5_HUMAN 79.322 0.993151 0.70024 TSPYL5 - Testis-specific Y-encoded-like protein 5 - Homo sapiens (Human) - TSPYL5 gene Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. Taurus_UMD|evm.model.AC_000169.1.124 P82925 RT31_BOVIN 100.000 0.994832 1.00259 MRPS31 - 28S ribosomal protein S31, mitochondrial precursor - Bos taurus (Bovine) - MRPS31 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit Taurus_UMD|evm.model.AC_000169.1.125 E1BPQ1 FOXO1_BOVIN 98.558 0.996753 0.987179 FOXO1 - Forkhead box protein O1 - Bos taurus (Bovine) - FOXO1 gene Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1. Promotes neural cell death (By similarity). Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (By similarity). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). Taurus_UMD|evm.model.AC_000169.1.128 Q3SZI7 COG6_BOVIN 99.848 0.99696 1.00152 COG6 - Conserved oligomeric Golgi complex subunit 6 - Bos taurus (Bovine) - COG6 gene Required for normal Golgi function. Taurus_UMD|evm.model.AC_000169.1.129 Q9Y693 LHPL6_HUMAN 97.500 0.99005 1.005 LHFPL6 - LHFPL tetraspan subfamily member 6 protein precursor - Homo sapiens (Human) - LHFPL6 gene membrane Taurus_UMD|evm.model.AC_000169.1.130 Q5JS37 NHLC3_HUMAN 83.673 0.870229 1.13256 NHLRC3 - NHL repeat-containing protein 3 precursor - Homo sapiens (Human) - NHLRC3 gene azurophil granule lumen, extracellular region, ubiquitin protein ligase activity, neutrophil degranulation, proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination Taurus_UMD|evm.model.AC_000169.1.131 Q86XN7 PRSR1_HUMAN 75.000 0.997817 0.970339 PROSER1 - Proline and serine-rich protein 1 - Homo sapiens (Human) - PROSER1 gene Taurus_UMD|evm.model.AC_000169.1.132 Q8TAV4 STML3_HUMAN 93.617 0.903382 0.71134 STOML3 - Stomatin-like protein 3 - Homo sapiens (Human) - STOML3 gene Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations. Taurus_UMD|evm.model.AC_000169.1.133 Q5SZK8 FREM2_HUMAN 89.824 0.99937 1.00126 FREM2 - FRAS1-related extracellular matrix protein 2 precursor - Homo sapiens (Human) - FREM2 gene Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (PubMed:15838507). Required for epidermal adhesion (PubMed:15838507). Involved in the development of eyelids and the anterior segment of the eyeballs (PubMed:29688405, PubMed:30802441). Taurus_UMD|evm.model.AC_000169.1.134 Q2KJG2 UFM1_BOVIN 100.000 0.621359 1.21176 UFM1 - Ubiquitin-fold modifier 1 precursor - Bos taurus (Bovine) - UFM1 gene Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription. Taurus_UMD|evm.model.AC_000169.1.137 P79100 TRPC4_BOVIN 100.000 0.997959 1.00102 TRPC4 - Short transient receptor potential channel 4 - Bos taurus (Bovine) - TRPC4 gene Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Acts as a cell-cell contact-dependent endothelial calcium entry channel (By similarity). Taurus_UMD|evm.model.AC_000169.1.138 Q15063 POSTN_HUMAN 94.976 0.997611 1.0012 POSTN - Periostin precursor - Homo sapiens (Human) - POSTN gene Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Taurus_UMD|evm.model.AC_000169.1.140 Q16254 E2F4_HUMAN 67.769 0.844961 0.312349 E2F4 - Transcription factor E2F4 - Homo sapiens (Human) - E2F4 gene Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Taurus_UMD|evm.model.AC_000169.1.141 Q8NEM7 SP20H_HUMAN 96.241 0.648352 1.05135 SUPT20H - Transcription factor SPT20 homolog - Homo sapiens (Human) - SUPT20H gene Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. Taurus_UMD|evm.model.AC_000169.1.142 Q2KHU3 EXOS8_BOVIN 72.632 0.992032 0.90942 EXOSC8 - Exosome complex component RRP43 - Bos taurus (Bovine) - EXOSC8 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs (By similarity). Taurus_UMD|evm.model.AC_000169.1.143 Q9Y673 ALG5_HUMAN 92.901 0.993846 1.00309 ALG5 - Dolichyl-phosphate beta-glucosyltransferase - Homo sapiens (Human) - ALG5 gene endoplasmic reticulum membrane, membrane, oligosaccharyl transferase activity, protein glycosylation, protein N-linked glycosylation, protein N-linked glycosylation via asparagine Taurus_UMD|evm.model.AC_000169.1.145 Q9JIW5 SMAD9_MOUSE 96.279 0.99536 1.00233 Smad9 - Mothers against decapentaplegic homolog 9 - Mus musculus (Mouse) - Smad9 gene Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). Has been shown to be activated by activin type I receptor-like kinases (ALK-2, ALK-3, ALK-6) which stimulate heteromerization between SMAD9 and SMAD4. May play a role in osteoblast differentiation and maturation. Taurus_UMD|evm.model.AC_000169.1.146 O00287 RFXAP_HUMAN 86.920 0.991597 0.875 RFXAP - Regulatory factor X-associated protein - Homo sapiens (Human) - RFXAP gene Part of the RFX complex that binds to the X-box of MHC II promoters. Taurus_UMD|evm.model.AC_000169.1.147 A2A2V5 SRTM1_HUMAN 97.196 0.981481 1.00935 SERTM1 - Serine-rich and transmembrane domain-containing protein 1 - Homo sapiens (Human) - SERTM1 gene intracellular membrane-bounded organelle Taurus_UMD|evm.model.AC_000169.1.148 Q6AY13 CCNA1_RAT 87.886 0.995261 1.00238 Ccna1 - Cyclin-A1 - Rattus norvegicus (Rat) - Ccna1 gene May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells (By similarity). Taurus_UMD|evm.model.AC_000169.1.149 A0JNJ3 SPART_BOVIN 100.000 0.99701 1.0015 SPART - Spartin - Bos taurus (Bovine) - SPART gene May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. Taurus_UMD|evm.model.AC_000169.1.150 Q9NX45 SOLH2_HUMAN 71.596 0.995316 1.00471 SOHLH2 - Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 - Homo sapiens (Human) - SOHLH2 gene Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity). Taurus_UMD|evm.model.AC_000169.1.151 O15075 DCLK1_HUMAN 99.595 0.87574 1.14189 DCLK1 - Serine/threonine-protein kinase DCLK1 - Homo sapiens (Human) - DCLK1 gene Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. Taurus_UMD|evm.model.AC_000169.1.152 Q8NFP9 NBEA_HUMAN 99.654 0.998273 0.393075 NBEA - Neurobeachin - Homo sapiens (Human) - NBEA gene Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). Taurus_UMD|evm.model.AC_000169.1.153 Q8NFP9 NBEA_HUMAN 93.069 0.568182 0.059742 NBEA - Neurobeachin - Homo sapiens (Human) - NBEA gene Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). Taurus_UMD|evm.model.AC_000169.1.155 Q2TBV1 RFC3_BOVIN 100.000 0.994398 1.00281 RFC3 - Replication factor C subunit 3 - Bos taurus (Bovine) - RFC3 gene The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Taurus_UMD|evm.model.AC_000169.1.156 Q9Y3M8 STA13_HUMAN 96.899 0.992248 0.115903 STARD13 - StAR-related lipid transfer protein 13 - Homo sapiens (Human) - STARD13 gene GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. Taurus_UMD|evm.model.AC_000169.1.157 Q8WP17 KLOT_MACFA 90.726 0.215721 1.12919 KL - Klotho precursor - Macaca fascicularis (Crab-eating macaque) - KL gene May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). Taurus_UMD|evm.model.AC_000169.1.158 Q9NTI5 PDS5B_HUMAN 98.206 0.998621 1.00207 PDS5B - Sister chromatid cohesion protein PDS5 homolog B - Homo sapiens (Human) - PDS5B gene Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. Taurus_UMD|evm.model.AC_000169.1.159 Q3T145 MDHC_BOVIN 90.446 0.787879 0.592814 MDH1 - Malate dehydrogenase, cytoplasmic - Bos taurus (Bovine) - MDH1 gene Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Taurus_UMD|evm.model.AC_000169.1.160 Q92802 N42L2_HUMAN 74.431 0.466942 2.07547 N4BP2L2 - NEDD4-binding protein 2-like 2 - Homo sapiens (Human) - N4BP2L2 gene extracellular exosome, nucleus, transcription repressor complex, enzyme binding, transcription corepressor activity, negative regulation of hematopoietic stem cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of hematopoietic stem cell proliferation Taurus_UMD|evm.model.AC_000169.1.161 Q29S05 N42L1_BOVIN 93.706 0.581967 1.4104 N4BP2L1 - NEDD4-binding protein 2-like 1 - Bos taurus (Bovine) - N4BP2L1 gene Taurus_UMD|evm.model.AC_000169.1.162 Q864S8 BRCA2_FELCA 73.643 0.482205 1.01661 BRCA2 - Breast cancer type 2 susceptibility protein homolog - Felis catus (Cat) - BRCA2 gene Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability, independently of its known role in homologous recombination (By similarity). Taurus_UMD|evm.model.AC_000169.1.163 Q1XFL1 ZAR1L_BOVIN 100.000 0.778098 1.09119 ZAR1L - ZAR1-like protein - Bos taurus (Bovine) - ZAR1L gene cytoplasm, mRNA binding involved in posttranscriptional gene silencing, translation Taurus_UMD|evm.model.AC_000169.1.164 Q5TBA9 FRY_HUMAN 97.909 0.97194 0.81613 FRY - Protein furry homolog - Homo sapiens (Human) - FRY gene Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. Taurus_UMD|evm.model.AC_000169.1.165 Q5XM32 RXFP2_CANLF 89.824 0.99729 1.00136 RXFP2 - Relaxin receptor 2 - Canis lupus familiaris (Dog) - RXFP2 gene Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity). Taurus_UMD|evm.model.AC_000169.1.166 Q3T139 R146B_BOVIN 99.490 0.989848 0.567723 RNF146B - E3 ubiquitin-protein ligase RNF146-B - Bos taurus (Bovine) - RNF146B gene E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination (By similarity). Taurus_UMD|evm.model.AC_000169.1.167 Q6Y288 B3GLT_HUMAN 86.709 0.995789 0.953815 B3GLCT - Beta-1,3-glucosyltransferase - Homo sapiens (Human) - B3GLCT gene O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. Taurus_UMD|evm.model.AC_000169.1.168 Q0IIM3 HS105_BOVIN 100.000 0.997674 1.00116 HSPH1 - Heat shock protein 105 kDa - Bos taurus (Bovine) - HSPH1 gene Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. Taurus_UMD|evm.model.AC_000169.1.169 B7FF06 WDY_DROGR 27.240 0.26971 0.823228 WDY - WD repeat-containing protein on Y chromosome - Drosophila grimshawi (Hawaiian fruit fly) - WDY gene Taurus_UMD|evm.model.AC_000169.1.170 A4IFN2 MEDAG_BOVIN 100.000 0.491557 1.75908 MEDAG - Mesenteric estrogen-dependent adipogenesis protein - Bos taurus (Bovine) - MEDAG gene Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes. Taurus_UMD|evm.model.AC_000169.1.171 Q148F2 AL5AP_BOVIN 100.000 0.987654 1.00621 ALOX5AP - Arachidonate 5-lipoxygenase-activating protein - Bos taurus (Bovine) - ALOX5AP gene Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity). Taurus_UMD|evm.model.AC_000169.1.172 Q5W0Q7 USPL1_HUMAN 70.377 0.997263 1.00366 USPL1 - SUMO-specific isopeptidase USPL1 - Homo sapiens (Human) - USPL1 gene SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172). Taurus_UMD|evm.model.AC_000169.1.173 P10103 HMGB1_BOVIN 100.000 0.990741 1.00465 HMGB1 - High mobility group protein B1 - Bos taurus (Bovine) - HMGB1 gene Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins (By similarity). Taurus_UMD|evm.model.AC_000169.1.176 A9RA82 KATL1_PAPAN 97.551 0.995927 1.00204 KATNAL1 - Katanin p60 ATPase-containing subunit A-like 1 - Papio anubis (Olive baboon) - KATNAL1 gene Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (By similarity). Taurus_UMD|evm.model.AC_000169.1.179 O95164 UBL3_HUMAN 100.000 0.943089 1.05128 UBL3 - Ubiquitin-like protein 3 precursor - Homo sapiens (Human) - UBL3 gene extracellular exosome Taurus_UMD|evm.model.AC_000169.1.181 P30825 SL7A1_HUMAN 91.256 0.996825 1.00159 SLC7A1 - High affinity cationic amino acid transporter 1 - Homo sapiens (Human) - SLC7A1 gene High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. Taurus_UMD|evm.model.AC_000169.1.182 Q5JR59 MTUS2_HUMAN 70.776 0.998536 0.997809 MTUS2 - Microtubule-associated tumor suppressor candidate 2 - Homo sapiens (Human) - MTUS2 gene Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. Taurus_UMD|evm.model.AC_000169.1.183 A5D7V7 S46A3_BOVIN 94.577 0.995434 0.950108 SLC46A3 - Solute carrier family 46 member 3 precursor - Bos taurus (Bovine) - SLC46A3 gene Taurus_UMD|evm.model.AC_000169.1.184 Q3SZV5 POMP_BOVIN 100.000 0.985915 1.00709 POMP - Proteasome maturation protein - Bos taurus (Bovine) - POMP gene Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation (By similarity). Mediates the association of 20S preproteasome with the endoplasmic reticulum (By similarity). Taurus_UMD|evm.model.AC_000169.1.186 P17948 VGFR1_HUMAN 81.260 0.954395 0.901345 FLT1 - Vascular endothelial growth factor receptor 1 precursor - Homo sapiens (Human) - FLT1 gene Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (Ref.11). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). Taurus_UMD|evm.model.AC_000169.1.187 Q58A45 PAN3_HUMAN 95.269 0.869565 0.985344 PAN3 - PAN2-PAN3 deadenylation complex subunit PAN3 - Homo sapiens (Human) - PAN3 gene Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. Taurus_UMD|evm.model.AC_000169.1.188 O15439 MRP4_HUMAN 88.525 0.444444 0.101887 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.189 F1M3J4 MRP4_RAT 71.698 0.96347 0.165283 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Taurus_UMD|evm.model.AC_000169.1.190 P36888 FLT3_HUMAN 90.760 0.997949 0.981873 FLT3 - Receptor-type tyrosine-protein kinase FLT3 precursor - Homo sapiens (Human) - FLT3 gene Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. Taurus_UMD|evm.model.AC_000169.1.191 A5PJD0 URAD_BOVIN 98.824 0.988304 1.00588 URAD - 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase - Bos taurus (Bovine) - URAD gene Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. Taurus_UMD|evm.model.AC_000169.1.192 P18111 CDX1_MOUSE 94.030 0.47482 0.518657 Cdx1 - Homeobox protein CDX-1 - Mus musculus (Mouse) - Cdx1 gene Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA. Taurus_UMD|evm.model.AC_000169.1.193 A1YF08 PDX1_GORGO 91.579 0.993007 1.00704 PDX1 - Pancreas/duodenum homeobox protein 1 - Gorilla gorilla gorilla (Western lowland gorilla) - PDX1 gene Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3' (By similarity). Taurus_UMD|evm.model.AC_000169.1.195 Q9H4S2 GSX1_HUMAN 95.539 0.992565 1.01894 GSX1 - GS homeobox 1 - Homo sapiens (Human) - GSX1 gene Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development. Taurus_UMD|evm.model.AC_000169.1.197 P0DPB5 RPC22_HUMAN 79.339 0.75817 1.2541 POLR1D - Protein POLR1D, isoform 2 - Homo sapiens (Human) - POLR1D gene cytosol, nucleoplasm, positive regulation of gene expression, epigenetic, positive regulation of type I interferon production, termination of RNA polymerase I transcription, transcription initiation from RNA polymerase I promoter Taurus_UMD|evm.model.AC_000169.1.198 Q8N448 LNX2_HUMAN 88.116 0.997072 0.989855 LNX2 - Ligand of Numb protein X 2 - Homo sapiens (Human) - LNX2 gene Taurus_UMD|evm.model.AC_000169.1.199 Q32KZ1 IF3M_BOVIN 100.000 0.931507 1.0696 MTIF3 - Translation initiation factor IF-3, mitochondrial precursor - Bos taurus (Bovine) - MTIF3 gene IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. Taurus_UMD|evm.model.AC_000169.1.200 Q92664 TF3A_HUMAN 79.609 0.909794 1.06301 GTF3A - Transcription factor IIIA - Homo sapiens (Human) - GTF3A gene Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity). Taurus_UMD|evm.model.AC_000169.1.201 Q6T310 RSLBA_HUMAN 88.511 0.975 0.991736 RASL11A - Ras-like protein family member 11A - Homo sapiens (Human) - RASL11A gene Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity). Taurus_UMD|evm.model.AC_000169.1.202 A5JSS2 RL21_CAPHI 100.000 0.987578 1.00625 RPL21 - 60S ribosomal protein L21 - Capra hircus (Goat) - RPL21 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000169.1.203 A5D9H7 UBP12_BOVIN 100.000 0.994595 1.00271 USP12 - Ubiquitin carboxyl-terminal hydrolase 12 - Bos taurus (Bovine) - USP12 gene Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. Taurus_UMD|evm.model.AC_000169.1.204 P47775 GPR12_HUMAN 93.114 0.99403 1.00299 GPR12 - G-protein coupled receptor 12 - Homo sapiens (Human) - GPR12 gene Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production. Taurus_UMD|evm.model.AC_000169.1.205 Q9UPY6 WASF3_HUMAN 93.825 0.996016 1 WASF3 - Wiskott-Aldrich syndrome protein family member 3 - Homo sapiens (Human) - WASF3 gene Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Taurus_UMD|evm.model.AC_000169.1.208 P49336 CDK8_HUMAN 99.525 0.9375 0.965517 CDK8 - Cyclin-dependent kinase 8 - Homo sapiens (Human) - CDK8 gene Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. Taurus_UMD|evm.model.AC_000169.1.209 Q9Y252 RNF6_HUMAN 73.907 0.997015 0.978102 RNF6 - E3 ubiquitin-protein ligase RNF6 - Homo sapiens (Human) - RNF6 gene E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. Taurus_UMD|evm.model.AC_000169.1.210 C7EXK4 AT8A2_BOVIN 66.520 0.981966 0.966028 ATP8A2 - Phospholipid-transporting ATPase IB - Bos taurus (Bovine) - ATP8A2 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (PubMed:31371510). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival. Taurus_UMD|evm.model.AC_000169.1.212 A6QPA0 SHSA2_BOVIN 100.000 0.993103 1.00346 SHISA2 - Protein shisa-2 homolog precursor - Bos taurus (Bovine) - SHISA2 gene Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Taurus_UMD|evm.model.AC_000169.1.213 C7EXK4 AT8A2_BOVIN 100.000 0.968254 0.054878 ATP8A2 - Phospholipid-transporting ATPase IB - Bos taurus (Bovine) - ATP8A2 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (PubMed:31371510). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival. Taurus_UMD|evm.model.AC_000169.1.214 Q0VBZ9 MRP_BOVIN 78.283 0.988235 0.858586 MARCKSL1 - MARCKS-related protein - Bos taurus (Bovine) - MARCKSL1 gene Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. Taurus_UMD|evm.model.AC_000169.1.215 Q9NTI2 AT8A2_HUMAN 93.143 0.786036 0.373737 ATP8A2 - Phospholipid-transporting ATPase IB - Homo sapiens (Human) - ATP8A2 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival. Taurus_UMD|evm.model.AC_000169.1.216 C7EXK4 AT8A2_BOVIN 96.667 0.608247 0.0844948 ATP8A2 - Phospholipid-transporting ATPase IB - Bos taurus (Bovine) - ATP8A2 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (PubMed:31371510). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival. Taurus_UMD|evm.model.AC_000169.1.217 C7EXK4 AT8A2_BOVIN 100.000 0.777429 0.277875 ATP8A2 - Phospholipid-transporting ATPase IB - Bos taurus (Bovine) - ATP8A2 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (PubMed:31371510). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival. Taurus_UMD|evm.model.AC_000169.1.218 C7EXK4 AT8A2_BOVIN 99.739 0.730402 0.455575 ATP8A2 - Phospholipid-transporting ATPase IB - Bos taurus (Bovine) - ATP8A2 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (PubMed:19778899, PubMed:24706822, PubMed:31371510, PubMed:26592152). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (PubMed:31371510). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival. Taurus_UMD|evm.model.AC_000169.1.219 Q8R332 NUP58_MOUSE 91.482 0.996593 1 Nup58 - Nucleoporin p58/p45 - Mus musculus (Mouse) - Nup58 gene Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. Taurus_UMD|evm.model.AC_000169.1.220 Q9Y217 MTMR6_HUMAN 93.881 0.996785 1.00161 MTMR6 - Myotubularin-related protein 6 - Homo sapiens (Human) - MTMR6 gene Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:19038970, PubMed:22647598). Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (PubMed:19038970, PubMed:22647598) (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). Taurus_UMD|evm.model.AC_000169.1.221 Q8N7J2 AMER2_HUMAN 81.395 0.199052 0.314456 AMER2 - APC membrane recruitment protein 2 - Homo sapiens (Human) - AMER2 gene Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Taurus_UMD|evm.model.AC_000169.1.223 Q5DU57 SPT13_MOUSE 83.053 0.491729 2.02744 Spata13 - Spermatogenesis-associated protein 13 - Mus musculus (Mouse) - Spata13 gene Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Taurus_UMD|evm.model.AC_000169.1.224 Q0II24 C1QT9_BOVIN 100.000 0.994012 1.003 C1QTNF9 - Complement C1q and tumor necrosis factor-related protein 9 precursor - Bos taurus (Bovine) - C1QTNF9 gene Taurus_UMD|evm.model.AC_000169.1.225 Q99797 MIPEP_HUMAN 87.079 0.995696 0.97756 MIPEP - Mitochondrial intermediate peptidase precursor - Homo sapiens (Human) - MIPEP gene Cleaves proteins, imported into the mitochondrion, to their mature size. Taurus_UMD|evm.model.AC_000169.1.226 Q9NS68 TNR19_HUMAN 72.315 0.981176 1.00473 TNFRSF19 - Tumor necrosis factor receptor superfamily member 19 precursor - Homo sapiens (Human) - TNFRSF19 gene Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death. Taurus_UMD|evm.model.AC_000169.1.227 Q9NZJ4 SACS_HUMAN 90.603 0.999126 0.999345 SACS - Sacsin - Homo sapiens (Human) - SACS gene Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins. Taurus_UMD|evm.model.AC_000169.1.228 Q0VCU7 SGCG_BOVIN 100.000 0.935484 1.06529 SGCG - Gamma-sarcoglycan - Bos taurus (Bovine) - SGCG gene Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Taurus_UMD|evm.model.AC_000169.1.232 Q95L12 FGF9_PIG 99.153 0.943548 0.596154 FGF9 - Fibroblast growth factor 9 precursor - Sus scrofa (Pig) - FGF9 gene Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). Taurus_UMD|evm.model.AC_000169.1.233 Q8IYU8 MICU2_HUMAN 84.065 0.99536 0.993088 MICU2 - Calcium uptake protein 2, mitochondrial precursor - Homo sapiens (Human) - MICU2 gene Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927). Taurus_UMD|evm.model.AC_000169.1.234 Q0VC89 ZDH20_BOVIN 95.495 0.922222 0.986301 ZDHHC20 - Palmitoyltransferase ZDHHC20 - Bos taurus (Bovine) - ZDHHC20 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains. Taurus_UMD|evm.model.AC_000169.1.235 Q3ZC04 RT63_BOVIN 100.000 0.980583 1.0098 MRPL57 - Ribosomal protein 63, mitochondrial - Bos taurus (Bovine) - MRPL57 gene mitochondrial inner membrane, mitochondrial ribosome, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000169.1.236 A8PUI7 SKA3_BOVIN 100.000 0.99505 1.00248 SKA3 - Spindle and kinetochore-associated protein 3 - Bos taurus (Bovine) - SKA3 gene Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. Taurus_UMD|evm.model.AC_000169.1.238 Q3T022 SAP18_BOVIN 100.000 0.878613 1.13072 SAP18 - Histone deacetylase complex subunit SAP18 - Bos taurus (Bovine) - SAP18 gene Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function (By similarity). Taurus_UMD|evm.model.AC_000169.1.239 Q7TSJ6 LATS2_MOUSE 76.422 0.663127 0.994242 Lats2 - Serine/threonine-protein kinase LATS2 - Mus musculus (Mouse) - Lats2 gene Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (By similarity). Taurus_UMD|evm.model.AC_000169.1.240 Q9C0E2 XPO4_HUMAN 94.296 0.998243 0.988705 XPO4 - Exportin-4 - Homo sapiens (Human) - XPO4 gene Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Taurus_UMD|evm.model.AC_000169.1.242 Q17QF2 EFMT1_BOVIN 100.000 0.991189 1.00442 EEF1AKMT1 - EEF1A lysine methyltransferase 1 - Bos taurus (Bovine) - EEF1AKMT1 gene Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'. Taurus_UMD|evm.model.AC_000169.1.243 Q8TAD2 IL17D_HUMAN 85.484 0.934343 0.980198 IL17D - Interleukin-17D precursor - Homo sapiens (Human) - IL17D gene Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells. Taurus_UMD|evm.model.AC_000169.1.244 Q61371 IFT88_MOUSE 94.296 0.717524 1.39199 Ift88 - Intraflagellar transport protein 88 homolog - Mus musculus (Mouse) - Ift88 gene Involved in primary cilium biogenesis (PubMed:31761534, PubMed:11062270, PubMed:21289087). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. Taurus_UMD|evm.model.AC_000169.1.245 Q8SPX7 CRYL1_BOVIN 100.000 0.993266 0.925234 CRYL1 - Lambda-crystallin homolog - Bos taurus (Bovine) - CRYL1 gene cytosol, L-gulonate 3-dehydrogenase activity, NAD+ binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Taurus_UMD|evm.model.AC_000169.1.246 Q8K0S9 SNPC1_MOUSE 71.429 0.473282 0.336761 Snapc1 - snRNA-activating protein complex subunit 1 - Mus musculus (Mouse) - Snapc1 gene Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity). Taurus_UMD|evm.model.AC_000169.1.247 Q5E9Z5 CXB6_BOVIN 100.000 0.992366 1.00383 GJB6 - Gap junction beta-6 protein - Bos taurus (Bovine) - GJB6 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Taurus_UMD|evm.model.AC_000169.1.248 A2VE67 CXB2_BOVIN 100.000 0.991189 1.00442 GJB2 - Gap junction beta-2 protein - Bos taurus (Bovine) - GJB2 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Taurus_UMD|evm.model.AC_000169.1.249 P41987 CXA3_BOVIN 100.000 0.995098 1.00246 GJA3 - Gap junction alpha-3 protein - Bos taurus (Bovine) - GJA3 gene Structural component of lens fiber gap junctions (PubMed:8088962). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:8088962). Taurus_UMD|evm.model.AC_000169.1.251 Q9UBW7 ZMYM2_HUMAN 94.190 0.905735 1.10167 ZMYM2 - Zinc finger MYM-type protein 2 - Homo sapiens (Human) - ZMYM2 gene May function as a transcription factor. Taurus_UMD|evm.model.AC_000169.1.254 A6QPH9 ZMYM5_BOVIN 100.000 0.997033 1.00149 ZMYM5 - Zinc finger MYM-type protein 5 - Bos taurus (Bovine) - ZMYM5 gene Functions as a transcriptional regulator. Taurus_UMD|evm.model.AC_000169.1.255 Q1LZD9 PSPC1_BOVIN 96.154 0.996024 0.967308 PSPC1 - Paraspeckle component 1 - Bos taurus (Bovine) - PSPC1 gene Together with NONO, required for the formation of nuclear paraspeckles. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Taurus_UMD|evm.model.AC_000169.1.256 Q99549 MPP8_HUMAN 80.070 0.989498 0.996512 MPHOSPH8 - M-phase phosphoprotein 8 - Homo sapiens (Human) - MPHOSPH8 gene Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Taurus_UMD|evm.model.AC_000169.1.257 E9PYK3 PARP4_MOUSE 73.856 0.646064 0.961402 Parp4 - Protein mono-ADP-ribosyltransferase PARP4 - Mus musculus (Mouse) - Parp4 gene Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Taurus_UMD|evm.model.AC_000169.1.258 Q5BQN8 CENPJ_PANTR 73.708 0.997786 1.01271 CENPJ - Centromere protein J - Pan troglodytes (Chimpanzee) - CENPJ gene Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (By similarity). Taurus_UMD|evm.model.AC_000169.1.259 Q4R3G4 RNF17_MACFA 81.995 0.817509 1.05737 RNF17 - RING finger protein 17 - Macaca fascicularis (Crab-eating macaque) - RNF17 gene Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity). Taurus_UMD|evm.model.AC_000169.1.260 P54707 AT12A_HUMAN 87.317 0.956969 1.02887 ATP12A - Potassium-transporting ATPase alpha chain 2 - Homo sapiens (Human) - ATP12A gene The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (PubMed:9774385, PubMed:7485470, PubMed:8853415, PubMed:11341842). Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (By similarity). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (PubMed:29391451). Taurus_UMD|evm.model.AC_000169.1.261 P54760 EPHB4_HUMAN 36.170 0.049417 1.82472 EPHB4 - Ephrin type-B receptor 4 precursor - Homo sapiens (Human) - EPHB4 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. Taurus_UMD|evm.model.AC_000169.1.262 Q5ZLM8 F133_CHICK 90.476 0.345833 0.96 FAM133 - Protein FAM133 - Gallus gallus (Chicken) - FAM133 gene Taurus_UMD|evm.model.AC_000169.1.263 Q2KJF9 T2EB_BOVIN 96.429 0.204545 0.456747 GTF2E2 - General transcription factor IIE subunit 2 - Bos taurus (Bovine) - GTF2E2 gene Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). Taurus_UMD|evm.model.AC_000169.1.264 Q2KJF9 T2EB_BOVIN 95.000 0.951613 0.214533 GTF2E2 - General transcription factor IIE subunit 2 - Bos taurus (Bovine) - GTF2E2 gene Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). Taurus_UMD|evm.model.AC_000169.1.265 P19536 COX5B_MOUSE 72.131 0.821918 0.570312 Cox5b - Cytochrome c oxidase subunit 5B, mitochondrial precursor - Mus musculus (Mouse) - Cox5b gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000169.1.267 Q3T0D0 HNRPK_BOVIN 76.353 0.993902 0.706897 HNRNPK - Heterogeneous nuclear ribonucleoprotein K - Bos taurus (Bovine) - HNRNPK gene One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest (By similarity). Taurus_UMD|evm.model.AC_000169.1.268 P28482 MK01_HUMAN 86.325 0.97479 0.330556 MAPK1 - Mitogen-activated protein kinase 1 - Homo sapiens (Human) - MAPK1 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity). Taurus_UMD|evm.model.AC_000169.1.271 Q9HC56 PCDH9_HUMAN 96.889 0.99115 0.1827 PCDH9 - Protocadherin-9 precursor - Homo sapiens (Human) - PCDH9 gene Potential calcium-dependent cell-adhesion protein. Taurus_UMD|evm.model.AC_000169.1.272 O02751 CFDP2_BOVIN 44.776 0.511628 0.217905 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000169.1.273 Q9HC56 PCDH9_HUMAN 99.704 0.987305 0.827809 PCDH9 - Protocadherin-9 precursor - Homo sapiens (Human) - PCDH9 gene Potential calcium-dependent cell-adhesion protein. Taurus_UMD|evm.model.AC_000169.1.274 Q9EQU5 SET_MOUSE 73.203 0.849162 0.619377 Set - Protein SET - Mus musculus (Mouse) - Set gene Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher (By similarity). Taurus_UMD|evm.model.AC_000169.1.276 P63170 DYL1_RAT 97.753 0.977778 1.01124 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Taurus_UMD|evm.model.AC_000169.1.277 P13471 RS14_RAT 86.885 0.821918 0.483444 Rps14 - 40S ribosomal protein S14 - Rattus norvegicus (Rat) - Rps14 gene cytosolic small ribosomal subunit, nucleolus, postsynaptic density, mRNA 5'-UTR binding, RNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome, translation regulator activity, erythrocyte differentiation, maturation of SSU-rRNA Taurus_UMD|evm.model.AC_000169.1.279 Q03274 PO22_POPJA 29.560 0.433702 0.509142 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 - Popillia japonica (Japanese beetle) Taurus_UMD|evm.model.AC_000169.1.281 Q9NR64 KLHL1_HUMAN 86.628 0.777273 0.294118 KLHL1 - Kelch-like protein 1 - Homo sapiens (Human) - KLHL1 gene May play a role in organizing the actin cytoskeleton of the brain cells. Taurus_UMD|evm.model.AC_000169.1.282 Q9UI36 DACH1_HUMAN 90.459 0.993939 0.653034 DACH1 - Dachshund homolog 1 - Homo sapiens (Human) - DACH1 gene Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). Taurus_UMD|evm.model.AC_000169.1.283 O19110 TSPY1_BOVIN 45.588 0.37931 0.548896 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000169.1.284 Q08AG7 MZT1_HUMAN 94.667 0.493151 1.78049 MZT1 - Mitotic-spindle organizing protein 1 - Homo sapiens (Human) - MZT1 gene Required for gamma-tubulin complex recruitment to the centrosome. Taurus_UMD|evm.model.AC_000169.1.285 Q6PGQ7 BORA_HUMAN 84.258 0.996429 1.00179 BORA - Protein aurora borealis - Homo sapiens (Human) - BORA gene Required for the activation of AURKA at the onset of mitosis. Taurus_UMD|evm.model.AC_000169.1.286 Q9Y2L1 RRP44_HUMAN 88.830 0.987899 0.948852 DIS3 - Exosome complex exonuclease RRP44 - Homo sapiens (Human) - DIS3 gene Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. Taurus_UMD|evm.model.AC_000169.1.287 Q8WXW3 PIBF1_HUMAN 89.696 0.997361 1.00132 PIBF1 - Progesterone-induced-blocking factor 1 - Homo sapiens (Human) - PIBF1 gene Plays a role in ciliogenesis. Taurus_UMD|evm.model.AC_000169.1.288 Q13887 KLF5_HUMAN 94.311 0.995604 0.995624 KLF5 - Krueppel-like factor 5 - Homo sapiens (Human) - KLF5 gene Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. Taurus_UMD|evm.model.AC_000169.1.289 Q9Y4X4 KLF12_HUMAN 99.005 0.995037 1.00249 KLF12 - Krueppel-like factor 12 - Homo sapiens (Human) - KLF12 gene Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. Taurus_UMD|evm.model.AC_000169.1.291 P11833 TBB_PARLI 93.125 0.987578 0.360179 Tubulin beta chain - Paracentrotus lividus (Common sea urchin) Taurus_UMD|evm.model.AC_000169.1.292 P09244 TBB7_CHICK 89.595 0.910053 0.425676 Tubulin beta-7 chain - Gallus gallus (Chicken) Taurus_UMD|evm.model.AC_000169.1.293 O60343 TBCD4_HUMAN 91.063 0.9982 0.855932 TBC1D4 - TBC1 domain family member 4 - Homo sapiens (Human) - TBC1D4 gene May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. Taurus_UMD|evm.model.AC_000169.1.294 O60343 TBCD4_HUMAN 91.018 0.768519 0.16641 TBC1D4 - TBC1 domain family member 4 - Homo sapiens (Human) - TBC1D4 gene May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. Taurus_UMD|evm.model.AC_000169.1.295 Q2KIY0 COMD6_BOVIN 100.000 0.839506 0.952941 COMMD6 - COMM domain-containing protein 6 - Bos taurus (Bovine) - COMMD6 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Inhibits TNF-induced NFKB1 activation. Taurus_UMD|evm.model.AC_000169.1.296 Q2TBG8 UCHL3_BOVIN 100.000 0.991342 1.00435 UCHL3 - Ubiquitin carboxyl-terminal hydrolase isozyme L3 - Bos taurus (Bovine) - UCHL3 gene Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3''. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome (By similarity). Taurus_UMD|evm.model.AC_000169.1.297 Q6QMZ7 RL12_CHILA 80.282 0.752688 0.563636 RPL12 - 60S ribosomal protein L12 - Chinchilla lanigera (Long-tailed chinchilla) - RPL12 gene Binds directly to 26S ribosomal RNA. Taurus_UMD|evm.model.AC_000169.1.298 Q8WWI1 LMO7_HUMAN 82.282 0.182941 1.05882 LMO7 - LIM domain only protein 7 - Homo sapiens (Human) - LMO7 gene apical plasma membrane, cell surface, cytoplasm, cytosol, focal adhesion, nuclear envelope, nucleus, ubiquitin ligase complex, ubiquitin-protein transferase activity, positive regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000169.1.299 Q99877 H2B1N_HUMAN 87.705 0.909774 1.05556 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000169.1.300 Q6WVG3 KCD12_MOUSE 97.248 0.993884 1 Kctd12 - BTB/POZ domain-containing protein KCTD12 - Mus musculus (Mouse) - Kctd12 gene Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization. Taurus_UMD|evm.model.AC_000169.1.301 A6NK06 IRG1_HUMAN 81.915 0.993644 0.981289 ACOD1 - Cis-aconitate decarboxylase - Homo sapiens (Human) - ACOD1 gene Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response (PubMed:23609450, PubMed:23610393). Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages (PubMed:23609450). Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages (PubMed:23610393). Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). Plays a role in the embryo implantation (By similarity). Taurus_UMD|evm.model.AC_000169.1.302 Q1ZYR0 CLN5_BOVIN 100.000 0.994429 1.00279 CLN5 - Ceroid-lipofuscinosis neuronal protein 5 - Bos taurus (Bovine) - CLN5 gene Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane. Taurus_UMD|evm.model.AC_000169.1.303 Q9UKT7 FBXL3_HUMAN 97.669 0.995349 1.00467 FBXL3 - F-box/LRR-repeat protein 3 - Homo sapiens (Human) - FBXL3 gene Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855). Taurus_UMD|evm.model.AC_000169.1.304 O75592 MYCB2_HUMAN 98.375 0.999572 1 MYCBP2 - E3 ubiquitin-protein ligase MYCBP2 - Homo sapiens (Human) - MYCBP2 gene Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (PubMed:29643511). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (PubMed:29643511). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (PubMed:18308511, PubMed:29643511). Plays a key role in neural development, probably by mediating ubiquitination of threonine residues on target proteins (Probable). Involved in different processes such as regulation of neurite outgrowth, synaptic growth, synaptogenesis and axon degeneration (By similarity). Required for the formation of major central nervous system axon tracts (By similarity). Required for proper axon growth by regulating axon navigation and axon branching: acts by regulating the subcellular location and stability of MAP3K12/DLK (By similarity). Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity). Regulates axon guidance in the olfactory system (By similarity). Involved in Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons: acts by promoting destabilization of NMNAT2, probably via ubiquitination of NMNAT2 (By similarity). Catalyzes ubiquitination of threonine and/or serine residues on NMNAT2, consequences of threonine and/or serine ubiquitination are however unknown (PubMed:29643511). Regulates the internalization of TRPV1 in peripheral sensory neurons (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin (PubMed:18308511, PubMed:27278822). Independently of the E3 ubiquitin-protein ligase activity, also acts as a guanosine exchange factor (GEF) for RAN in neurons of dorsal root ganglia (PubMed:26304119). May function as a facilitator or regulator of transcriptional activation by MYC (PubMed:9689053). Acts in concert with HUWE1 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Taurus_UMD|evm.model.AC_000169.1.305 O95171 SCEL_HUMAN 74.513 0.995828 1.04506 SCEL - Sciellin - Homo sapiens (Human) - SCEL gene May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. Taurus_UMD|evm.model.AC_000169.1.306 Q8ND83 SLAI1_HUMAN 95.443 0.879464 0.788732 SLAIN1 - SLAIN motif-containing protein 1 - Homo sapiens (Human) - SLAIN1 gene Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation. Taurus_UMD|evm.model.AC_000169.1.307 P28088 EDNRB_BOVIN 100.000 0.995475 1.00227 EDNRB - Endothelin receptor type B precursor - Bos taurus (Bovine) - EDNRB gene Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000169.1.308 Q6HA08 ASTL_HUMAN 76.923 0.9375 0.222738 ASTL - Astacin-like metalloendopeptidase precursor - Homo sapiens (Human) - ASTL gene Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity). Taurus_UMD|evm.model.AC_000169.1.309 P17208 PO4F1_MOUSE 100.000 0.981651 0.258907 Pou4f1 - POU domain, class 4, transcription factor 1 - Mus musculus (Mouse) - Pou4f1 gene Multifunctional transcription factor with different regions mediating its different effects (PubMed:10640682, PubMed:8621561, PubMed:9694219, PubMed:9722627). Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:8621561, PubMed:17668438). Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor (PubMed:12934100). Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain) (PubMed:9722627). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins (PubMed:8972215). Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity (PubMed:9448000). May positively regulate POU4F2 and POU4F3 (PubMed:8876243). Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord (PubMed:22326227). Plays a role in TNFSF11-mediated terminal osteoclast differentiation (PubMed:17668438). Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site (PubMed:12441296). Taurus_UMD|evm.model.AC_000169.1.310 Q5W0B1 OBI1_HUMAN 88.981 0.997214 0.988981 OBI1 - ORC ubiquitin ligase 1 - Homo sapiens (Human) - OBI1 gene E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). Taurus_UMD|evm.model.AC_000169.1.311 Q5T8P6 RBM26_HUMAN 96.723 0.997967 0.97716 RBM26 - RNA-binding protein 26 - Homo sapiens (Human) - RBM26 gene nucleus, RNA binding, negative regulation of phosphatase activity Taurus_UMD|evm.model.AC_000169.1.312 Q9NV92 NFIP2_HUMAN 86.012 0.905405 1.10119 NDFIP2 - NEDD4 family-interacting protein 2 - Homo sapiens (Human) - NDFIP2 gene Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). Taurus_UMD|evm.model.AC_000169.1.313 Q5R893 H2B1_PONAB 92.857 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000169.1.314 Q3SZ62 PGAM1_BOVIN 88.189 0.991525 0.929134 PGAM1 - Phosphoglycerate mutase 1 - Bos taurus (Bovine) - PGAM1 gene Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. Taurus_UMD|evm.model.AC_000169.1.315 Q08E39 SPY2_BOVIN 100.000 0.993671 1.00317 SPRY2 - Protein sprouty homolog 2 - Bos taurus (Bovine) - SPRY2 gene Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (By similarity). Taurus_UMD|evm.model.AC_000169.1.317 Q58CQ2 ARC1B_BOVIN 93.011 0.994609 0.997312 ARPC1B - Actin-related protein 2/3 complex subunit 1B - Bos taurus (Bovine) - ARPC1B gene Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Taurus_UMD|evm.model.AC_000169.1.318 P15927 RFA2_HUMAN 85.000 0.97541 0.451852 RPA2 - Replication protein A 32 kDa subunit - Homo sapiens (Human) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Taurus_UMD|evm.model.AC_000169.1.319 P56966 GGPPS_BOVIN 98.039 0.980392 0.17 GGPS1 - Geranylgeranyl pyrophosphate synthase - Bos taurus (Bovine) - GGPS1 gene Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Taurus_UMD|evm.model.AC_000169.1.320 O08658 NUP88_RAT 98.387 0.984 0.168464 Nup88 - Nuclear pore complex protein Nup88 - Rattus norvegicus (Rat) - Nup88 gene Component of nuclear pore complex. Taurus_UMD|evm.model.AC_000169.1.321 A6H767 NP1L1_BOVIN 89.846 0.983607 0.780051 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Taurus_UMD|evm.model.AC_000169.1.322 Q96PX8 SLIK1_HUMAN 99.138 0.997131 1.00144 SLITRK1 - SLIT and NTRK-like protein 1 precursor - Homo sapiens (Human) - SLITRK1 gene It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Enhances neuronal dendrite outgrowth (PubMed:16224024, PubMed:19640509). Taurus_UMD|evm.model.AC_000169.1.324 Q9H5Y7 SLIK6_HUMAN 93.120 0.997628 1.00238 SLITRK6 - SLIT and NTRK-like protein 6 precursor - Homo sapiens (Human) - SLITRK6 gene Regulator of neurite outgrowth required for normal hearing and vision. Taurus_UMD|evm.model.AC_000169.1.326 Q5RB63 HTSF1_PONAB 75.587 0.983051 1.01724 HTATSF1 - HIV Tat-specific factor 1 homolog - Pongo abelii (Sumatran orangutan) - HTATSF1 gene Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation (By similarity). Taurus_UMD|evm.model.AC_000169.1.327 Q810B7 SLIK5_MOUSE 96.454 0.142712 1.02508 Slitrk5 - SLIT and NTRK-like protein 5 precursor - Mus musculus (Mouse) - Slitrk5 gene Suppresses neurite outgrowth. Taurus_UMD|evm.model.AC_000169.1.328 Q17QW2 TM39B_BOVIN 90.826 0.955752 0.229675 TMEM39B - Transmembrane protein 39B - Bos taurus (Bovine) - TMEM39B gene membrane Taurus_UMD|evm.model.AC_000169.1.329 P19338 NUCL_HUMAN 85.714 0.205015 0.95493 NCL - Nucleolin - Homo sapiens (Human) - NCL gene Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Taurus_UMD|evm.model.AC_000169.1.331 Q8WTP9 XAGE3_HUMAN 40.541 0.634783 1.03604 XAGE3 - X antigen family member 3 - Homo sapiens (Human) - XAGE3 gene Taurus_UMD|evm.model.AC_000169.1.334 Q9UQ07 MOK_HUMAN 56.065 0.996552 0.692124 MOK - MAPK/MAK/MRK overlapping kinase - Homo sapiens (Human) - MOK gene Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. Taurus_UMD|evm.model.AC_000169.1.336 O62640 PIAP_PIG 92.000 0.0720721 0.930168 PIAP - Putative inhibitor of apoptosis - Sus scrofa (Pig) - PIAP gene cytoplasm, nucleus, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ubiquitin protein ligase activity, negative regulation of apoptotic process, negative regulation of necroptotic process, positive regulation of protein ubiquitination, regulation of cell cycle Taurus_UMD|evm.model.AC_000169.1.337 Q9R087 GPC6_MOUSE 99.363 0.996815 0.565766 Gpc6 - Glypican-6 precursor - Mus musculus (Mouse) - Gpc6 gene Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling (By similarity). Taurus_UMD|evm.model.AC_000169.1.338 Q95119 TYRP2_BOVIN 90.600 0.959916 0.916828 DCT - L-dopachrome tautomerase precursor - Bos taurus (Bovine) - DCT gene Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA). Taurus_UMD|evm.model.AC_000169.1.339 O02705 HS90A_PIG 97.514 0.99449 0.495225 HSP90AA1 - Heat shock protein HSP 90-alpha - Sus scrofa (Pig) - HSP90AA1 gene Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Mediates the association of TOMM70 with IRF3 or TBK1 in mitochodria outer membrane which promotes host antiviral response. Taurus_UMD|evm.model.AC_000169.1.340 Q76LV2 HS90A_BOVIN 98.343 0.989011 0.248295 HSP90AA1 - Heat shock protein HSP 90-alpha - Bos taurus (Bovine) - HSP90AA1 gene Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Mediates the association of TOMM70 with IRF3 or TBK1 in mitochodria outer membrane which promotes host antiviral response. Taurus_UMD|evm.model.AC_000169.1.341 A6QLW2 TGDS_BOVIN 100.000 0.994382 1.00282 TGDS - dTDP-D-glucose 4,6-dehydratase - Bos taurus (Bovine) - TGDS gene dTDP-glucose 4,6-dehydratase activity Taurus_UMD|evm.model.AC_000169.1.342 Q86V85 GP180_HUMAN 91.818 0.995465 1.00227 GPR180 - Integral membrane protein GPR180 precursor - Homo sapiens (Human) - GPR180 gene Taurus_UMD|evm.model.AC_000169.1.343 Q6RVD7 SX21B_DANRE 66.667 0.991632 0.97551 sox21b - Transcription factor Sox-21-B - Danio rerio (Zebrafish) - sox21b gene Acts as a negative regulator of transcription. Taurus_UMD|evm.model.AC_000169.1.345 O15439 MRP4_HUMAN 91.820 0.407346 0.904151 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.346 F1M3J4 MRP4_RAT 71.547 0.97043 0.280755 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Taurus_UMD|evm.model.AC_000169.1.347 E9Q236 MRP4_MOUSE 77.181 0.635193 0.175849 Abcc4 - ATP-binding cassette sub-family C member 4 - Mus musculus (Mouse) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Taurus_UMD|evm.model.AC_000169.1.348 O15439 MRP4_HUMAN 89.241 0.363426 0.326038 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.349 F1M3J4 MRP4_RAT 61.235 0.95283 0.32 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Taurus_UMD|evm.model.AC_000169.1.350 Q58DW5 RL5_BOVIN 92.965 0.413361 1.61279 RPL5 - 60S ribosomal protein L5 - Bos taurus (Bovine) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Taurus_UMD|evm.model.AC_000169.1.351 E9Q236 MRP4_MOUSE 63.158 0.778947 0.0716981 Abcc4 - ATP-binding cassette sub-family C member 4 - Mus musculus (Mouse) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Taurus_UMD|evm.model.AC_000169.1.352 F1M3J4 MRP4_RAT 69.477 0.988473 0.261887 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Taurus_UMD|evm.model.AC_000169.1.353 O15439 MRP4_HUMAN 71.014 0.300885 0.170566 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.354 O15439 MRP4_HUMAN 76.015 0.665025 0.306415 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.355 O15439 MRP4_HUMAN 69.193 0.866667 0.860377 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.356 F1M3J4 MRP4_RAT 67.593 0.699346 0.115472 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Taurus_UMD|evm.model.AC_000169.1.357 O15439 MRP4_HUMAN 61.856 0.923077 0.0784906 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.358 O15439 MRP4_HUMAN 78.788 0.875 0.0845283 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.359 E9Q236 MRP4_MOUSE 75.862 0.115756 0.938868 Abcc4 - ATP-binding cassette sub-family C member 4 - Mus musculus (Mouse) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Taurus_UMD|evm.model.AC_000169.1.360 F1M3J4 MRP4_RAT 74.576 0.753247 0.0581132 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Taurus_UMD|evm.model.AC_000169.1.362 O15439 MRP4_HUMAN 83.333 0.0474277 0.938868 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.363 O15439 MRP4_HUMAN 73.418 0.309638 1.10415 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.364 O95503 CBX6_HUMAN 97.727 0.133956 0.779126 CBX6 - Chromobox protein homolog 6 - Homo sapiens (Human) - CBX6 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). Taurus_UMD|evm.model.AC_000169.1.365 E9Q236 MRP4_MOUSE 82.432 0.0454829 1.21132 Abcc4 - ATP-binding cassette sub-family C member 4 - Mus musculus (Mouse) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Taurus_UMD|evm.model.AC_000169.1.366 O15439 MRP4_HUMAN 80.851 0.073132 0.474717 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.368 O15439 MRP4_HUMAN 62.609 0.990991 0.0837736 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.369 O15439 MRP4_HUMAN 75.510 0.183187 0.601509 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.370 F1M3J4 MRP4_RAT 76.970 0.982036 0.126038 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Taurus_UMD|evm.model.AC_000169.1.371 O15439 MRP4_HUMAN 76.136 0.811728 0.244528 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.372 O15439 MRP4_HUMAN 80.851 0.244094 0.287547 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.373 O15439 MRP4_HUMAN 72.278 0.987963 0.815094 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.374 O15439 MRP4_HUMAN 49.648 0.972509 0.219623 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.375 F1M3J4 MRP4_RAT 66.102 0.918605 0.129811 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Taurus_UMD|evm.model.AC_000169.1.376 O15439 MRP4_HUMAN 75.641 0.047066 1.23472 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.377 O15439 MRP4_HUMAN 76.555 0.268167 1.17358 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.379 E9Q236 MRP4_MOUSE 63.333 0.983333 0.045283 Abcc4 - ATP-binding cassette sub-family C member 4 - Mus musculus (Mouse) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Taurus_UMD|evm.model.AC_000169.1.380 O15439 MRP4_HUMAN 72.262 0.980598 0.933585 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.381 O15439 MRP4_HUMAN 75.758 0.128773 0.375094 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.382 O15439 MRP4_HUMAN 79.787 0.556886 0.126038 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.383 O15439 MRP4_HUMAN 87.770 0.0831826 1.25208 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.384 O15439 MRP4_HUMAN 67.293 0.989327 0.919245 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.385 O15439 MRP4_HUMAN 74.797 0.62383 0.886792 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.386 F1M3J4 MRP4_RAT 69.634 0.931373 0.153962 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Taurus_UMD|evm.model.AC_000169.1.387 F1M3J4 MRP4_RAT 83.871 0.14218 0.159245 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Taurus_UMD|evm.model.AC_000169.1.388 O15439 MRP4_HUMAN 75.130 0.569527 0.510189 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.389 E9Q236 MRP4_MOUSE 90.909 0.0537084 0.295094 Abcc4 - ATP-binding cassette sub-family C member 4 - Mus musculus (Mouse) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Taurus_UMD|evm.model.AC_000169.1.390 E9Q236 MRP4_MOUSE 67.769 0.449438 0.201509 Abcc4 - ATP-binding cassette sub-family C member 4 - Mus musculus (Mouse) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Taurus_UMD|evm.model.AC_000169.1.391 O15439 MRP4_HUMAN 72.208 0.981912 0.292075 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000169.1.392 E9Q236 MRP4_MOUSE 68.354 0.220339 0.26717 Abcc4 - ATP-binding cassette sub-family C member 4 - Mus musculus (Mouse) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Taurus_UMD|evm.model.AC_000169.1.393 E9Q236 MRP4_MOUSE 80.000 0.0964798 0.578868 Abcc4 - ATP-binding cassette sub-family C member 4 - Mus musculus (Mouse) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Taurus_UMD|evm.model.AC_000169.1.394 F1M3J4 MRP4_RAT 78.894 0.360656 0.41434 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Taurus_UMD|evm.model.AC_000169.1.395 Q5E9L0 CLD10_BOVIN 100.000 0.991379 1.00433 CLDN10 - Claudin-10 - Bos taurus (Bovine) - CLDN10 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function. Taurus_UMD|evm.model.AC_000169.1.396 Q86YF9 DZIP1_HUMAN 78.784 0.997701 1.00346 DZIP1 - Zinc finger protein DZIP1 - Homo sapiens (Human) - DZIP1 gene May participate in spermatogenesis via its interaction with DAZ1 (PubMed:15081113). Has a role in primary cilium formation (PubMed:19852954). Taurus_UMD|evm.model.AC_000169.1.397 Q12887 COX10_HUMAN 72.449 0.460784 0.460497 COX10 - Protoheme IX farnesyltransferase, mitochondrial precursor - Homo sapiens (Human) - COX10 gene Converts protoheme IX and farnesyl diphosphate to heme O. Taurus_UMD|evm.model.AC_000169.1.398 Q27968 DNJC3_BOVIN 99.802 0.99604 1.00198 DNAJC3 - DnaJ homolog subfamily C member 3 precursor - Bos taurus (Bovine) - DNAJC3 gene Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A (PubMed:7511204). May inhibit EIF2AK3/PERK activity (By similarity). Taurus_UMD|evm.model.AC_000169.1.399 Q9NYU1 UGGG2_HUMAN 82.980 0.950126 1.04485 UGGT2 - UDP-glucose:glycoprotein glucosyltransferase 2 precursor - Homo sapiens (Human) - UGGT2 gene Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Taurus_UMD|evm.model.AC_000169.1.400 Q9QYK4 H6ST3_MOUSE 89.916 0.764516 0.659574 Hs6st3 - Heparan-sulfate 6-O-sulfotransferase 3 - Mus musculus (Mouse) - Hs6st3 gene 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Taurus_UMD|evm.model.AC_000169.1.402 Q8IZP7 H6ST3_HUMAN 92.797 0.928854 0.537155 HS6ST3 - Heparan-sulfate 6-O-sulfotransferase 3 - Homo sapiens (Human) - HS6ST3 gene 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Taurus_UMD|evm.model.AC_000169.1.403 Q3SYR7 RL9_BOVIN 97.396 0.989637 1.00521 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000169.1.405 Q96P68 OXGR1_HUMAN 85.163 0.994083 1.00297 OXGR1 - 2-oxoglutarate receptor 1 - Homo sapiens (Human) - OXGR1 gene Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity). Taurus_UMD|evm.model.AC_000169.1.406 Q5R4F5 MBNL2_PONAB 97.885 0.896739 0.986595 MBNL2 - Muscleblind-like protein 2 - Pongo abelii (Sumatran orangutan) - MBNL2 gene Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM) (By similarity). Taurus_UMD|evm.model.AC_000169.1.407 Q5R988 RAP2A_PONAB 100.000 0.98913 1.00546 RAP2A - Ras-related protein Rap-2a precursor - Pongo abelii (Sumatran orangutan) - RAP2A gene Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (By similarity). Taurus_UMD|evm.model.AC_000169.1.410 O00410 IPO5_HUMAN 97.832 0.998195 1.01003 IPO5 - Importin-5 - Homo sapiens (Human) - IPO5 gene Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Taurus_UMD|evm.model.AC_000169.1.411 Q9Y4F1 FARP1_HUMAN 96.491 0.982456 0.0545455 FARP1 - FERM, ARHGEF and pleckstrin domain-containing protein 1 - Homo sapiens (Human) - FARP1 gene Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). Taurus_UMD|evm.model.AC_000169.1.412 Q9Y4F1 FARP1_HUMAN 91.010 0.969578 0.97512 FARP1 - FERM, ARHGEF and pleckstrin domain-containing protein 1 - Homo sapiens (Human) - FARP1 gene Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). Taurus_UMD|evm.model.AC_000169.1.413 Q99KH8 STK24_MOUSE 84.834 0.910628 0.960557 Stk24 - Serine/threonine-protein kinase 24 - Mus musculus (Mouse) - Stk24 gene Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. Acts as a key regulator of axon regeneration in the optic nerve and radial nerve (By similarity). Taurus_UMD|evm.model.AC_000169.1.414 Q8WMX5 S15A1_CANLF 83.451 0.997167 0.997175 SLC15A1 - Solute carrier family 15 member 1 - Canis lupus familiaris (Dog) - SLC15A1 gene Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen. Taurus_UMD|evm.model.AC_000169.1.416 Q9BZ29 DOCK9_HUMAN 92.930 0.961318 1.01208 DOCK9 - Dedicator of cytokinesis protein 9 - Homo sapiens (Human) - DOCK9 gene Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. Taurus_UMD|evm.model.AC_000169.1.417 Q4R910 UBAC2_MACFA 87.308 0.670984 1.11884 UBAC2 - Ubiquitin-associated domain-containing protein 2 precursor - Macaca fascicularis (Crab-eating macaque) - UBAC2 gene Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (By similarity). In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). Taurus_UMD|evm.model.AC_000169.1.418 A5PLE7 GP83A_DANRE 41.404 0.794944 0.967391 gpr183a - G-protein coupled receptor 183-A - Danio rerio (Zebrafish) - gpr183a gene G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (By similarity). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Taurus_UMD|evm.model.AC_000169.1.419 Q5R8Y6 TM9S2_PONAB 98.515 0.955766 0.954751 TM9SF2 - Transmembrane 9 superfamily member 2 precursor - Pongo abelii (Sumatran orangutan) - TM9SF2 gene In the intracellular compartments, may function as a channel or small molecule transporter. Taurus_UMD|evm.model.AC_000169.1.420 Q8N0X4 CLYBL_HUMAN 90.096 0.912281 1.00588 CLYBL - Citramalyl-CoA lyase, mitochondrial precursor - Homo sapiens (Human) - CLYBL gene Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341). Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (PubMed:29056341, PubMed:24334609). Also displays malyl-CoA thioesterase activity (PubMed:29056341). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (PubMed:24334609, PubMed:29056341). Also has very weak citramalate synthase activity in vitro (PubMed:24334609, PubMed:29056341). Taurus_UMD|evm.model.AC_000169.1.421 Q7TQ40 ZIC5_MOUSE 96.196 0.592233 0.496785 Zic5 - Zinc finger protein ZIC 5 - Mus musculus (Mouse) - Zic5 gene Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA. Taurus_UMD|evm.model.AC_000169.1.422 O95409 ZIC2_HUMAN 96.787 0.995935 0.924812 ZIC2 - Zinc finger protein ZIC 2 - Homo sapiens (Human) - ZIC2 gene Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos. Taurus_UMD|evm.model.AC_000169.1.424 P0DTA4 PCCA_PIG 93.648 0.998185 0.754795 PCCA - Propionyl-CoA carboxylase alpha chain, mitochondrial precursor - Sus scrofa (Pig) - PCCA gene This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:13752080). Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:13752080). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then tranfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:13752080). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (PubMed:13752080). Taurus_UMD|evm.model.AC_000169.1.425 Q0VFX9 GGACT_BOVIN 100.000 0.444149 2.2381 GGACT - Gamma-glutamylaminecyclotransferase - Bos taurus (Bovine) - GGACT gene Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine. Taurus_UMD|evm.model.AC_000169.1.426 Q5T4D3 TMTC4_HUMAN 91.093 0.997301 1 TMTC4 - Protein O-mannosyl-transferase TMTC4 - Homo sapiens (Human) - TMTC4 gene Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Taurus_UMD|evm.model.AC_000169.1.427 Q8IZF0 NALCN_HUMAN 96.145 0.998839 0.990794 NALCN - Sodium leak channel non-selective protein - Homo sapiens (Human) - NALCN gene Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and controls neuronal excitability (PubMed:17448995). Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, NALCN activity is enhanced/modulated by several GPCRs. Required for normal respiratory rhythm and neonatal survival. Involved in systemic osmoregulation by controlling the serum sodium concentration. NALCN is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability (By similarity). Taurus_UMD|evm.model.AC_000169.1.429 O95965 ITGBL_HUMAN 94.334 0.99435 0.716599 ITGBL1 - Integrin beta-like protein 1 precursor - Homo sapiens (Human) - ITGBL1 gene focal adhesion, plasma membrane, integrin binding, cell adhesion, cell adhesion mediated by integrin, cell migration, cell-matrix adhesion, integrin-mediated signaling pathway Taurus_UMD|evm.model.AC_000169.1.430 P70379 FGF14_MOUSE 98.160 0.987805 0.663968 Fgf14 - Fibroblast growth factor 14 - Mus musculus (Mouse) - Fgf14 gene Probably involved in nervous system development and function. Taurus_UMD|evm.model.AC_000169.1.431 Q92915 FGF14_HUMAN 100.000 0.526316 0.384615 FGF14 - Fibroblast growth factor 14 - Homo sapiens (Human) - FGF14 gene Probably involved in nervous system development and function. Taurus_UMD|evm.model.AC_000169.1.433 A5PK39 TPP2_BOVIN 99.920 0.9984 1.0008 TPP2 - Tripeptidyl-peptidase 2 - Bos taurus (Bovine) - TPP2 gene Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity). Taurus_UMD|evm.model.AC_000169.1.434 A6QP81 MT21C_BOVIN 100.000 0.992248 1.00389 METTL21C - Protein-lysine methyltransferase METTL21C - Bos taurus (Bovine) - METTL21C gene Protein-lysine methyltransferase. Taurus_UMD|evm.model.AC_000169.1.435 Q8NDH2 CC168_HUMAN 53.348 0.952731 0.388254 CCDC168 - Coiled-coil domain-containing protein 168 - Homo sapiens (Human) - CCDC168 gene Taurus_UMD|evm.model.AC_000169.1.436 Q3ZC52 TEX30_BOVIN 99.490 0.0253873 34.2902 TEX30 - Testis-expressed protein 30 - Bos taurus (Bovine) - TEX30 gene Taurus_UMD|evm.model.AC_000169.1.438 Q6UW63 PLGT2_HUMAN 93.426 0.996024 1.00199 POGLUT2 - Protein O-glucosyltransferase 2 precursor - Homo sapiens (Human) - POGLUT2 gene Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1 and NOTCH3 (PubMed:30127001). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001). Taurus_UMD|evm.model.AC_000169.1.439 Q86UB2 BIVM_HUMAN 92.644 0.996024 1 BIVM - Basic immunoglobulin-like variable motif-containing protein - Homo sapiens (Human) - BIVM gene extracellular space Taurus_UMD|evm.model.AC_000169.1.440 P28715 ERCC5_HUMAN 71.547 0.98527 1.03035 ERCC5 - DNA excision repair protein ERCC-5 - Homo sapiens (Human) - ERCC5 gene Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:8206890, PubMed:8090225, PubMed:8078765, PubMed:7651464, PubMed:32821917, PubMed:32522879). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:8090225, PubMed:8078765, PubMed:32821917, PubMed:32522879). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). Taurus_UMD|evm.model.AC_000169.1.441 Q58DC7 MT21E_BOVIN 99.655 0.993127 1.00345 METTL21E - Protein-lysine methyltransferase METTL21E - Bos taurus (Bovine) - METTL21E gene Protein-lysine methyltransferase. Taurus_UMD|evm.model.AC_000169.1.442 Q60414 NTCP2_CRIGR 81.517 0.954545 0.632184 SLC10A2 - Ileal sodium/bile acid cotransporter - Cricetulus griseus (Chinese hamster) - SLC10A2 gene Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity). Taurus_UMD|evm.model.AC_000169.1.446 O46415 FRIL_BOVIN 61.290 0.652482 0.805714 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000169.1.447 O46415 FRIL_BOVIN 53.957 0.836364 0.942857 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000169.1.449 P52799 EFNB2_HUMAN 89.869 0.983819 0.927928 EFNB2 - Ephrin-B2 precursor - Homo sapiens (Human) - EFNB2 gene Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. Taurus_UMD|evm.model.AC_000169.1.450 Q9NWB6 ARGL1_HUMAN 99.545 0.969027 0.827839 ARGLU1 - Arginine and glutamate-rich protein 1 - Homo sapiens (Human) - ARGLU1 gene Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. Taurus_UMD|evm.model.AC_000169.1.454 P35232 PHB_HUMAN 95.187 0.673913 1.01471 PHB - Prohibitin - Homo sapiens (Human) - PHB gene Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity). Taurus_UMD|evm.model.AC_000169.1.456 A4IFM1 F155A_BOVIN 100.000 0.635135 0.323851 FAM155A - Transmembrane protein FAM155A - Bos taurus (Bovine) - FAM155A gene plasma membrane, calcium ion import across plasma membrane Taurus_UMD|evm.model.AC_000169.1.457 A4IFM1 F155A_BOVIN 96.610 0.47541 0.266958 FAM155A - Transmembrane protein FAM155A - Bos taurus (Bovine) - FAM155A gene plasma membrane, calcium ion import across plasma membrane Taurus_UMD|evm.model.AC_000169.1.458 P80272 HMGN2_PIG 97.753 0.967033 1.01111 HMGN2 - Non-histone chromosomal protein HMG-17 - Sus scrofa (Pig) - HMGN2 gene Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). Taurus_UMD|evm.model.AC_000169.1.461 P49917 DNLI4_HUMAN 89.243 0.997807 1.0011 LIG4 - DNA ligase 4 - Homo sapiens (Human) - LIG4 gene Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Taurus_UMD|evm.model.AC_000169.1.462 Q7L211 ABHDD_HUMAN 97.923 0.994083 1.00297 ABHD13 - Protein ABHD13 - Homo sapiens (Human) - ABHD13 gene membrane, palmitoyl-(protein) hydrolase activity Taurus_UMD|evm.model.AC_000169.1.463 Q9Y275 TN13B_HUMAN 63.889 0.92517 0.515789 TNFSF13B - Tumor necrosis factor ligand superfamily member 13B - Homo sapiens (Human) - TNFSF13B gene Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Taurus_UMD|evm.model.AC_000169.1.464 Q9Y275 TN13B_HUMAN 92.188 0.976923 0.45614 TNFSF13B - Tumor necrosis factor ligand superfamily member 13B - Homo sapiens (Human) - TNFSF13B gene Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Taurus_UMD|evm.model.AC_000169.1.466 Q9Y6X6 MYO16_HUMAN 84.328 0.649146 0.81916 MYO16 - Unconventional myosin-XVI - Homo sapiens (Human) - MYO16 gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity). Taurus_UMD|evm.model.AC_000169.1.467 Q9Y6X6 MYO16_HUMAN 83.133 0.987654 0.0435953 MYO16 - Unconventional myosin-XVI - Homo sapiens (Human) - MYO16 gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity). Taurus_UMD|evm.model.AC_000169.1.470 Q9Y4H2 IRS2_HUMAN 84.570 0.242447 1.0142 IRS2 - Insulin receptor substrate 2 - Homo sapiens (Human) - IRS2 gene May mediate the control of various cellular processes by insulin. Taurus_UMD|evm.model.AC_000169.1.471 Q7SIB2 CO4A1_BOVIN 98.502 0.998786 0.986818 COL4A1 - Collagen alpha-1(IV) chain precursor - Bos taurus (Bovine) - COL4A1 gene Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Taurus_UMD|evm.model.AC_000169.1.472 Q7SIB3 CO4A2_BOVIN 99.559 0.125347 7.94273 COL4A2 - Collagen alpha-2(IV) chain - Bos taurus (Bovine) - COL4A2 gene Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits angiogenesis and tumor growth (By similarity). Taurus_UMD|evm.model.AC_000169.1.473 Q9NX57 RAB20_HUMAN 79.487 0.991379 0.991453 RAB20 - Ras-related protein Rab-20 - Homo sapiens (Human) - RAB20 gene Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Taurus_UMD|evm.model.AC_000169.1.474 E1BNQ4 NNRD_BOVIN 100.000 0.993939 1.00304 NAXD - ATP-dependent (S)-NAD(P)H-hydrate dehydratase precursor - Bos taurus (Bovine) - NAXD gene Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Taurus_UMD|evm.model.AC_000169.1.475 Q2KIF8 SYCM_BOVIN 99.640 0.996403 1.0018 CARS2 - Cysteine--tRNA ligase, mitochondrial precursor - Bos taurus (Bovine) - CARS2 gene cytoplasm, ATP binding, cysteine-tRNA ligase activity, cysteinyl-tRNA aminoacylation Taurus_UMD|evm.model.AC_000169.1.476 Q9NXR5 ANR10_HUMAN 78.063 0.831325 0.988095 ANKRD10 - Ankyrin repeat domain-containing protein 10 - Homo sapiens (Human) - ANKRD10 gene Taurus_UMD|evm.model.AC_000169.1.477 Q9QXV3 ING1_MOUSE 88.608 0.87037 0.967742 Ing1 - Inhibitor of growth protein 1 - Mus musculus (Mouse) - Ing1 gene Isoform 1 inhibits p53-dependent transcriptional activation and may function as an oncoprotein. Isoform 2 acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53-responsive genes and may act as a tumor suppressor. Taurus_UMD|evm.model.AC_000169.1.478 Q9D2S4 SPAC7_MOUSE 42.308 0.554945 1 Spaca7 - Sperm acrosome-associated protein 7 precursor - Mus musculus (Mouse) - Spaca7 gene Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion. Taurus_UMD|evm.model.AC_000169.1.479 O55043 ARHG7_RAT 93.963 0.533058 1.87307 Arhgef7 - Rho guanine nucleotide exchange factor 7 - Rattus norvegicus (Rat) - Arhgef7 gene Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). Taurus_UMD|evm.model.AC_000169.1.480 Q3SZT4 TEX29_BOVIN 100.000 0.986486 1.0068 TEX29 - Testis-expressed protein 29 - Bos taurus (Bovine) - TEX29 gene Taurus_UMD|evm.model.AC_000169.1.488 O00570 SOX1_HUMAN 92.583 0.994595 0.946292 SOX1 - Transcription factor SOX-1 - Homo sapiens (Human) - SOX1 gene Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). Taurus_UMD|evm.model.AC_000169.1.492 Q96KW9 SPAC7_HUMAN 36.782 0.945055 0.933333 SPACA7 - Sperm acrosome-associated protein 7 precursor - Homo sapiens (Human) - SPACA7 gene Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion. Taurus_UMD|evm.model.AC_000169.1.493 Q96CW5 GCP3_HUMAN 91.621 0.997797 1.0011 TUBGCP3 - Gamma-tubulin complex component 3 - Homo sapiens (Human) - TUBGCP3 gene Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Taurus_UMD|evm.model.AC_000169.1.497 P98196 AT11A_HUMAN 91.855 0.904177 1.07672 ATP11A - Phospholipid-transporting ATPase IH - Homo sapiens (Human) - ATP11A gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:25947375, PubMed:26567335, PubMed:29799007, PubMed:30018401). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib. Taurus_UMD|evm.model.AC_000169.1.499 Q63406 MCF2L_RAT 79.732 0.884219 1.09748 Mcf2l - Guanine nucleotide exchange factor DBS - Rattus norvegicus (Rat) - Mcf2l gene Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways. Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus. Taurus_UMD|evm.model.AC_000169.1.500 P22457 FA7_BOVIN 100.000 0.995536 1.00224 F7 - Coagulation factor VII precursor - Bos taurus (Bovine) - F7 gene Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. Taurus_UMD|evm.model.AC_000169.1.501 P00743 FA10_BOVIN 100.000 0.995943 1.00203 F10 - Coagulation factor X precursor - Bos taurus (Bovine) - F10 gene Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Taurus_UMD|evm.model.AC_000169.1.502 P00744 PROZ_BOVIN 100.000 0.891648 1.11869 PROZ - Vitamin K-dependent protein Z - Bos taurus (Bovine) - PROZ gene Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Taurus_UMD|evm.model.AC_000169.1.503 Q2TBN6 PCID2_BOVIN 96.602 0.99505 0.990196 PCID2 - PCI domain-containing protein 2 - Bos taurus (Bovine) - PCID2 gene Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells (By similarity). Taurus_UMD|evm.model.AC_000169.1.504 Q13619 CUL4A_HUMAN 94.366 0.97905 0.943347 CUL4A - Cullin-4A - Homo sapiens (Human) - CUL4A gene Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). With CUL4B, contributes to ribosome biogenesis (PubMed:26711351). Taurus_UMD|evm.model.AC_000169.1.505 Q05204 LAMP1_BOVIN 100.000 0.995122 1.00244 LAMP1 - Lysosome-associated membrane glycoprotein 1 precursor - Bos taurus (Bovine) - LAMP1 gene caveola, cytolytic granule membrane, endosome membrane, late endosome membrane, lysosomal membrane, membrane raft, plasma membrane, establishment of protein localization to organelle, protein stabilization Taurus_UMD|evm.model.AC_000169.1.506 Q5TC63 GRTP1_HUMAN 79.822 0.65362 1.52083 GRTP1 - Growth hormone-regulated TBC protein 1 - Homo sapiens (Human) - GRTP1 gene May act as a GTPase-activating protein for Rab family protein(s). Taurus_UMD|evm.model.AC_000169.1.507 Q3ZBM1 ARHL1_BOVIN 99.718 0.205113 4.86158 ADPRHL1 - [Protein ADP-ribosylarginine] hydrolase-like protein 1 - Bos taurus (Bovine) - ADPRHL1 gene autophagosome, recycling endosome, GTPase activator activity, activation of GTPase activity, intracellular protein transport, regulation of autophagosome assembly Taurus_UMD|evm.model.AC_000169.1.508 Q8BZJ7 DCNL2_MOUSE 88.500 0.952153 0.80695 Dcun1d2 - DCN1-like protein 2 - Mus musculus (Mouse) - Dcun1d2 gene Contributes to the neddylation of all cullins by transfering NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and plays an essential role in the regulation of SCF (SKP1-CUL1-F-box protein)-type complexes activity. Taurus_UMD|evm.model.AC_000169.1.509 Q8BH01 TMCO3_MOUSE 81.416 0.99705 1 Tmco3 - Transmembrane and coiled-coil domain-containing protein 3 precursor - Mus musculus (Mouse) - Tmco3 gene Probable Na(+)/H(+) antiporter. Taurus_UMD|evm.model.AC_000169.1.510 Q17QZ4 TFDP1_BOVIN 100.000 0.995134 1.00244 TFDP1 - Transcription factor Dp-1 - Bos taurus (Bovine) - TFDP1 gene Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (By similarity). Taurus_UMD|evm.model.AC_000169.1.511 P18434 ATP4B_PIG 89.655 0.993127 1.00345 ATP4B - Potassium-transporting ATPase subunit beta - Sus scrofa (Pig) - ATP4B gene The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (PubMed:29618813, PubMed:19387495). Taurus_UMD|evm.model.AC_000169.1.512 P28327 GRK1_BOVIN 100.000 0.996441 1.00178 GRK1 - Rhodopsin kinase GRK1 precursor - Bos taurus (Bovine) - GRK1 gene Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:12686556, PubMed:16675451, PubMed:21299498). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity). Taurus_UMD|evm.model.AC_000169.1.513 Q8WV15 T255B_HUMAN 70.552 0.984472 0.98773 TMEM255B - Transmembrane protein 255B - Homo sapiens (Human) - TMEM255B gene Taurus_UMD|evm.model.AC_000169.1.514 Q14393 GAS6_HUMAN 80.908 0.986068 0.952802 GAS6 - Growth arrest-specific protein 6 precursor - Homo sapiens (Human) - GAS6 gene Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Taurus_UMD|evm.model.AC_000169.1.516 A0A1B0GUA9 CM046_HUMAN 57.009 0.990291 0.971698 C13orf46 - Uncharacterized protein C13orf46 - Homo sapiens (Human) - C13orf46 gene Taurus_UMD|evm.model.AC_000169.1.517 Q28013 RASA3_BOVIN 99.640 0.997605 1.0012 RASA3 - Ras GTPase-activating protein 3 - Bos taurus (Bovine) - RASA3 gene Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4). Taurus_UMD|evm.model.AC_000169.1.519 Q98TF8 RL22_CHICK 77.778 0.17931 1.13281 RPL22 - 60S ribosomal protein L22 - Gallus gallus (Chicken) - RPL22 gene RNA binding, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000169.1.520 Q13042 CDC16_HUMAN 97.581 0.996779 1.00161 CDC16 - Cell division cycle protein 16 homolog - Homo sapiens (Human) - CDC16 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Taurus_UMD|evm.model.AC_000169.1.521 Q9H1J1 REN3A_HUMAN 76.096 0.883041 1.07773 UPF3A - Regulator of nonsense transcripts 3A - Homo sapiens (Human) - UPF3A gene Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. Taurus_UMD|evm.model.AC_000169.1.522 Q96JM3 CHAP1_HUMAN 86.626 0.997516 0.991379 CHAMP1 - Chromosome alignment-maintaining phosphoprotein 1 - Homo sapiens (Human) - CHAMP1 gene Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. Taurus_UMD|evm.model.AC_000169.1.525 Q8VGS1 O1038_MOUSE 70.861 0.993377 0.473354 Olfr1038 - Olfactory receptor 1038 - Mus musculus (Mouse) - Olfr1038 gene Potential odorant receptor. Taurus_UMD|evm.model.AC_000170.1.1 Q9UPS8 ANR26_HUMAN 65.789 0.255079 0.259064 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000170.1.2 Q13136 LIPA1_HUMAN 75.824 0.135338 0.553245 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000170.1.3 Q8NH73 OR4S2_HUMAN 83.234 0.988024 0.536977 OR4S2 - Olfactory receptor 4S2 - Homo sapiens (Human) - OR4S2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000170.1.4 Q5JUK9 PAGE3_HUMAN 44.444 0.56 1.54867 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Taurus_UMD|evm.model.AC_000170.1.5 Q5JUK9 PAGE3_HUMAN 49.474 0.746032 1.11504 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Taurus_UMD|evm.model.AC_000170.1.6 Q8NH72 OR4C6_HUMAN 64.398 0.972678 0.592233 OR4C6 - Olfactory receptor 4C6 - Homo sapiens (Human) - OR4C6 gene Odorant receptor. Taurus_UMD|evm.model.AC_000170.1.8 Q9H1E5 TMX4_HUMAN 79.656 0.985673 1 TMX4 - Thioredoxin-related transmembrane protein 4 precursor - Homo sapiens (Human) - TMX4 gene nuclear inner membrane Taurus_UMD|evm.model.AC_000170.1.9 P10894 PLCB1_BOVIN 100.000 0.983051 0.0485197 PLCB1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 - Bos taurus (Bovine) - PLCB1 gene Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier. Taurus_UMD|evm.model.AC_000170.1.10 P10894 PLCB1_BOVIN 96.111 0.998206 0.916941 PLCB1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 - Bos taurus (Bovine) - PLCB1 gene Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier. Taurus_UMD|evm.model.AC_000170.1.12 Q07722 PLCB4_BOVIN 95.920 0.8285 1.17986 PLCB4 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 - Bos taurus (Bovine) - PLCB4 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. Taurus_UMD|evm.model.AC_000170.1.13 A4FV27 LAMP5_BOVIN 100.000 0.992883 1.00357 LAMP5 - Lysosome-associated membrane glycoprotein 5 precursor - Bos taurus (Bovine) - LAMP5 gene Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. Taurus_UMD|evm.model.AC_000170.1.14 Q9P286 PAK5_HUMAN 94.159 0.931258 1.07232 PAK5 - Serine/threonine-protein kinase PAK 5 - Homo sapiens (Human) - PAK5 gene Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. Taurus_UMD|evm.model.AC_000170.1.15 Q99877 H2B1N_HUMAN 92.135 0.967033 0.722222 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000170.1.17 Q9NU02 ANKE1_HUMAN 87.355 0.996139 1.00129 ANKEF1 - Ankyrin repeat and EF-hand domain-containing protein 1 - Homo sapiens (Human) - ANKEF1 gene Taurus_UMD|evm.model.AC_000170.1.18 P60881 SNP25_RAT 95.631 0.990338 1.00485 Snap25 - Synaptosomal-associated protein 25 - Rattus norvegicus (Rat) - Snap25 gene t-SNARE involved in the molecular regulation of neurotransmitter release (PubMed:8243676, PubMed:8103915). May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells (PubMed:12403834). Taurus_UMD|evm.model.AC_000170.1.19 Q9NPJ1 MKKS_HUMAN 79.649 0.866058 1.15263 MKKS - McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin - Homo sapiens (Human) - MKKS gene Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (PubMed:20080638). Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis (PubMed:28753627). Taurus_UMD|evm.model.AC_000170.1.20 Q5VYV7 SLX4I_HUMAN 72.289 0.904412 0.666667 SLX4IP - Protein SLX4IP - Homo sapiens (Human) - SLX4IP gene Taurus_UMD|evm.model.AC_000170.1.21 P78504 JAG1_HUMAN 95.813 0.998359 1.00082 JAG1 - Protein jagged-1 precursor - Homo sapiens (Human) - JAG1 gene Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). Taurus_UMD|evm.model.AC_000170.1.23 Q03255 SRY_BOVIN 100.000 0.991304 1.00437 SRY - Sex-determining region Y protein - Bos taurus (Bovine) - SRY gene Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Taurus_UMD|evm.model.AC_000170.1.26 M3XQV7 BTBD3_MUSPF 97.180 0.996212 0.992481 BTBD3 - BTB/POZ domain-containing protein 3 - Mustela putorius furo (European domestic ferret) - BTBD3 gene Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed. Taurus_UMD|evm.model.AC_000170.1.29 Q9NUV7 SPTC3_HUMAN 83.144 0.814607 0.967391 SPTLC3 - Serine palmitoyltransferase 3 - Homo sapiens (Human) - SPTLC3 gene Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. SPT complexes containing SPTLC3 generate shorter chain sphingoid bases compared to complexes containing SPTLC2. The SPTLC1-SPTLC3-SPTSSA isozyme uses C12-CoA, C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. On the other hand, the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference. Taurus_UMD|evm.model.AC_000170.1.30 B1AKI9 ISM1_HUMAN 92.840 0.947846 0.950431 ISM1 - Isthmin-1 precursor - Homo sapiens (Human) - ISM1 gene Acts as an angiogenesis inhibitor. Taurus_UMD|evm.model.AC_000170.1.31 Q9H6P5 TASP1_HUMAN 97.949 0.989796 0.466667 TASP1 - Threonine aspartase 1 - Homo sapiens (Human) - TASP1 gene Protease responsible for KMT2A/MLL1 processing and activation (PubMed:14636557). It also activates KMT2D/MLL2 (By similarity). Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A (By similarity) (PubMed:14636557). Taurus_UMD|evm.model.AC_000170.1.32 Q9H501 ESF1_HUMAN 83.764 0.946324 1.00705 ESF1 - ESF1 homolog - Homo sapiens (Human) - ESF1 gene May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). Taurus_UMD|evm.model.AC_000170.1.33 Q5TEU4 NDUF5_HUMAN 88.623 0.962428 1.0029 NDUFAF5 - Arginine-hydroxylase NDUFAF5, mitochondrial precursor - Homo sapiens (Human) - NDUFAF5 gene Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages (PubMed:18940309, PubMed:27226634). Acts by mediating hydroxylation of 'Arg-111' of NDUFS7 (PubMed:27226634). May also have methyltransferase activity (Probable). Taurus_UMD|evm.model.AC_000170.1.34 Q5TEA6 SE1L2_HUMAN 89.971 0.997097 1.00145 SEL1L2 - Protein sel-1 homolog 2 precursor - Homo sapiens (Human) - SEL1L2 gene Hrd1p ubiquitin ligase ERAD-L complex, ubiquitin-dependent ERAD pathway Taurus_UMD|evm.model.AC_000170.1.36 Q9NZU0 FLRT3_HUMAN 97.689 0.996923 1.00154 FLRT3 - Leucine-rich repeat transmembrane protein FLRT3 precursor - Homo sapiens (Human) - FLRT3 gene Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity). Taurus_UMD|evm.model.AC_000170.1.37 Q3UYG8 MACD2_MOUSE 97.436 0.372549 0.214737 Macrod2 - ADP-ribose glycohydrolase MACROD2 - Mus musculus (Mouse) - Macrod2 gene Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Taurus_UMD|evm.model.AC_000170.1.38 A1Z1Q3 MACD2_HUMAN 88.095 0.41 0.235294 MACROD2 - ADP-ribose glycohydrolase MACROD2 - Homo sapiens (Human) - MACROD2 gene Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Taurus_UMD|evm.model.AC_000170.1.39 A1Z1Q3 MACD2_HUMAN 69.811 0.820312 0.301176 MACROD2 - ADP-ribose glycohydrolase MACROD2 - Homo sapiens (Human) - MACROD2 gene Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Taurus_UMD|evm.model.AC_000170.1.40 P62752 RL23A_RAT 65.517 0.817308 0.666667 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000170.1.41 Q96L93 KI16B_HUMAN 85.736 0.998457 0.984055 KIF16B - Kinesin-like protein KIF16B - Homo sapiens (Human) - KIF16B gene Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. Taurus_UMD|evm.model.AC_000170.1.43 P08579 RU2B_HUMAN 99.111 0.99115 1.00444 SNRPB2 - U2 small nuclear ribonucleoprotein B'' - Homo sapiens (Human) - SNRPB2 gene Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128). Taurus_UMD|evm.model.AC_000170.1.44 Q9NRC9 OTOR_HUMAN 88.372 0.984615 1.01562 OTOR - Otoraplin precursor - Homo sapiens (Human) - OTOR gene cartilage condensation, sensory perception of sound Taurus_UMD|evm.model.AC_000170.1.45 A4IFH4 PSF1_BOVIN 73.228 0.99115 0.576531 GINS1 - DNA replication complex GINS protein PSF1 - Bos taurus (Bovine) - GINS1 gene Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. Taurus_UMD|evm.model.AC_000170.1.46 Q9UPS8 ANR26_HUMAN 60.500 0.880734 0.127485 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000170.1.47 Q0EEE2 PTHD3_MOUSE 49.083 0.964444 0.248344 Ptchd3 - Patched domain-containing protein 3 - Mus musculus (Mouse) - Ptchd3 gene May play a role in sperm development or sperm function. Taurus_UMD|evm.model.AC_000170.1.48 Q8TBE9 NANP_HUMAN 94.355 0.991968 1.00403 NANP - N-acylneuraminate-9-phosphatase - Homo sapiens (Human) - NANP gene cytosol, N-acylneuraminate-9-phosphatase activity, N-acetylneuraminate biosynthetic process Taurus_UMD|evm.model.AC_000170.1.49 Q9Y2I6 NINL_HUMAN 71.266 0.674464 0.742402 NINL - Ninein-like protein - Homo sapiens (Human) - NINL gene Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. Taurus_UMD|evm.model.AC_000170.1.50 Q9UPS8 ANR26_HUMAN 64.286 0.141045 0.783626 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000170.1.51 P03359 POL_WMSV 50.714 0.785311 0.10492 pol - Gag-Pol polyprotein - Woolly monkey sarcoma virus (WMSV) - pol gene Plays a role in budding and is processed by the viral protease during virion maturation outside the cell. During budding, it recruits, in a PPXY-dependent or independent manner, Nedd4-like ubiquitin ligases that conjugate ubiquitin molecules to Gag-Pol, or to Gag-Pol binding host factors. Interaction with HECT ubiquitin ligases probably links the viral protein to the host ESCRT pathway and facilitates release. Taurus_UMD|evm.model.AC_000170.1.52 Q9Y2I6 NINL_HUMAN 63.563 0.230694 0.740232 NINL - Ninein-like protein - Homo sapiens (Human) - NINL gene Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. Taurus_UMD|evm.model.AC_000170.1.54 A6NC57 ANR62_HUMAN 59.016 0.501031 0.528899 ANKRD62 - Ankyrin repeat domain-containing protein 62 - Homo sapiens (Human) - ANKRD62 gene Taurus_UMD|evm.model.AC_000170.1.55 Q9UPS8 ANR26_HUMAN 62.857 0.5 0.162573 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000170.1.56 Q9UPS8 ANR26_HUMAN 61.765 0.085613 1.15439 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000170.1.57 Q9D6Y1 CCDC3_MOUSE 89.453 0.927273 1.00733 Ccdc3 - Coiled-coil domain-containing protein 3 precursor - Mus musculus (Mouse) - Ccdc3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (By similarity). Positively regulates lipid accumulation in adipose cells (PubMed:25605713). Taurus_UMD|evm.model.AC_000170.1.58 Q32KN9 PRLD1_BOVIN 45.366 0.722222 0.739726 PRELID1 - PRELI domain-containing protein 1, mitochondrial precursor - Bos taurus (Bovine) - PRELID1 gene Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs (By similarity). Taurus_UMD|evm.model.AC_000170.1.60 Q8IU85 KCC1D_HUMAN 97.746 0.961957 0.955844 CAMK1D - Calcium/calmodulin-dependent protein kinase type 1D - Homo sapiens (Human) - CAMK1D gene Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. Taurus_UMD|evm.model.AC_000170.1.61 Q2YDG3 CD123_BOVIN 100.000 0.994048 1.00299 CDC123 - Cell division cycle protein 123 homolog - Bos taurus (Bovine) - CDC123 gene Required for S phase entry of the cell cycle. Taurus_UMD|evm.model.AC_000170.1.62 Q9UKK9 NUDT5_HUMAN 88.426 0.981735 1 NUDT5 - ADP-sugar pyrophosphatase - Homo sapiens (Human) - NUDT5 gene Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:19699693, PubMed:21389046, PubMed:17052728). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). Taurus_UMD|evm.model.AC_000170.1.63 Q9JLR1 S61A2_MOUSE 100.000 0.995807 1.0021 Sec61a2 - Protein transport protein Sec61 subunit alpha isoform 2 - Mus musculus (Mouse) - Sec61a2 gene Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). Taurus_UMD|evm.model.AC_000170.1.64 Q5R7H0 DHTK1_PONAB 90.549 0.9859 1.00326 DHTKD1 - Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - DHTKD1 gene The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Taurus_UMD|evm.model.AC_000170.1.65 Q9HAU5 RENT2_HUMAN 97.642 0.998428 1 UPF2 - Regulator of nonsense transcripts 2 - Homo sapiens (Human) - UPF2 gene Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. Taurus_UMD|evm.model.AC_000170.1.66 Q8C5R2 PRSR2_MOUSE 64.509 0.995604 0.96603 Proser2 - Proline and serine-rich protein 2 - Mus musculus (Mouse) - Proser2 gene Taurus_UMD|evm.model.AC_000170.1.68 Q10126 YSM6_CAEEL 28.000 0.821429 0.602151 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000170.1.70 Q96DC8 ECHD3_HUMAN 82.000 0.993355 0.993399 ECHDC3 - Enoyl-CoA hydratase domain-containing protein 3, mitochondrial precursor - Homo sapiens (Human) - ECHDC3 gene May play a role in fatty acid biosynthesis and insulin sensitivity. Taurus_UMD|evm.model.AC_000170.1.71 Q92738 US6NL_HUMAN 79.162 0.997546 0.9843 USP6NL - USP6 N-terminal-like protein - Homo sapiens (Human) - USP6NL gene Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. Taurus_UMD|evm.model.AC_000170.1.72 Q5R8Y8 CELF2_PONAB 99.531 0.979263 0.854331 CELF2 - CUGBP Elav-like family member 2 - Pongo abelii (Sumatran orangutan) - CELF2 gene RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (By similarity). Taurus_UMD|evm.model.AC_000170.1.75 Q9H5I5 PIEZ2_HUMAN 86.842 0.355769 0.0377907 PIEZO2 - Piezo-type mechanosensitive ion channel component 2 - Homo sapiens (Human) - PIEZO2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. Taurus_UMD|evm.model.AC_000170.1.76 Q5R893 H2B1_PONAB 93.651 0.984 0.992063 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000170.1.78 Q13574 DGKZ_HUMAN 39.766 0.910345 0.15625 DGKZ - Diacylglycerol kinase zeta - Homo sapiens (Human) - DGKZ gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PubMed:9159104, PubMed:19744926, PubMed:22108654). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PubMed:15544348, PubMed:19744926, PubMed:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PubMed:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity). Taurus_UMD|evm.model.AC_000170.1.79 Q08DV0 GATA3_BOVIN 99.775 0.995506 1.00451 GATA3 - Trans-acting T-cell-specific transcription factor GATA-3 - Bos taurus (Bovine) - GATA3 gene Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses (By similarity). Taurus_UMD|evm.model.AC_000170.1.80 Q5VWG9 TAF3_HUMAN 88.627 0.997856 1.00431 TAF3 - Transcription initiation factor TFIID subunit 3 - Homo sapiens (Human) - TAF3 gene Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process. Taurus_UMD|evm.model.AC_000170.1.81 P05631 ATPG_BOVIN 100.000 0.993311 1.00336 ATP5F1C - ATP synthase subunit gamma, mitochondrial precursor - Bos taurus (Bovine) - ATP5F1C gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Taurus_UMD|evm.model.AC_000170.1.82 O60870 KIN17_HUMAN 97.201 0.994911 1 KIN - DNA/RNA-binding protein KIN17 - Homo sapiens (Human) - KIN gene Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. Taurus_UMD|evm.model.AC_000170.1.83 O02668 ITIH2_PIG 86.681 0.926471 1.09091 ITIH2 - Inter-alpha-trypsin inhibitor heavy chain H2 precursor - Sus scrofa (Pig) - ITIH2 gene May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Taurus_UMD|evm.model.AC_000170.1.84 Q5RKI1 IF4A2_RAT 100.000 0.2125 0.786241 Eif4a2 - Eukaryotic initiation factor 4A-II - Rattus norvegicus (Rat) - Eif4a2 gene ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). Taurus_UMD|evm.model.AC_000170.1.85 A2VE29 ITIH5_BOVIN 96.667 0.913889 0.382979 ITIH5 - Inter-alpha-trypsin inhibitor heavy chain H5 precursor - Bos taurus (Bovine) - ITIH5 gene May act as a tumor suppressor. Taurus_UMD|evm.model.AC_000170.1.87 A2VE29 ITIH5_BOVIN 97.063 0.989418 0.804255 ITIH5 - Inter-alpha-trypsin inhibitor heavy chain H5 precursor - Bos taurus (Bovine) - ITIH5 gene May act as a tumor suppressor. Taurus_UMD|evm.model.AC_000170.1.89 Q5VUG0 SMBT2_HUMAN 90.940 0.997758 0.997763 SFMBT2 - Scm-like with four MBT domains protein 2 - Homo sapiens (Human) - SFMBT2 gene Transcriptional repressor of HOXB13 gene. Taurus_UMD|evm.model.AC_000170.1.92 Q04759 KPCT_HUMAN 96.176 0.997171 1.00142 PRKCQ - Protein kinase C theta type - Homo sapiens (Human) - PRKCQ gene Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). Taurus_UMD|evm.model.AC_000170.1.93 Q5R9C1 F263_PONAB 96.327 0.987879 0.963035 PFKFB3 - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 - Pongo abelii (Sumatran orangutan) - PFKFB3 gene Synthesis and degradation of fructose 2,6-bisphosphate. Taurus_UMD|evm.model.AC_000170.1.94 Q96I25 SPF45_HUMAN 99.002 0.995025 1.00249 RBM17 - Splicing factor 45 - Homo sapiens (Human) - RBM17 gene Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. Taurus_UMD|evm.model.AC_000170.1.95 P12342 IL2RA_BOVIN 98.507 0.992565 0.978182 IL2RA - Interleukin-2 receptor subunit alpha precursor - Bos taurus (Bovine) - IL2RA gene Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. Taurus_UMD|evm.model.AC_000170.1.96 Q13261 I15RA_HUMAN 55.230 0.819788 1.05993 IL15RA - Interleukin-15 receptor subunit alpha precursor - Homo sapiens (Human) - IL15RA gene High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770). Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910). Taurus_UMD|evm.model.AC_000170.1.97 Q8NFZ0 FBH1_HUMAN 89.506 0.997945 0.932886 FBH1 - F-box DNA helicase 1 - Homo sapiens (Human) - FBH1 gene 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578). Taurus_UMD|evm.model.AC_000170.1.98 Q9UPS8 ANR26_HUMAN 61.656 0.538333 0.350877 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000170.1.99 Q9UPS8 ANR26_HUMAN 66.822 0.855372 0.14152 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000170.1.100 Q6ZQ12 NINL_MOUSE 53.247 0.30603 0.63056 Ninl - Ninein-like protein - Mus musculus (Mouse) - Ninl gene Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly (By similarity). Taurus_UMD|evm.model.AC_000170.1.101 Q811D2 ANR26_MOUSE 55.172 0.132867 0.271347 Ankrd26 - Ankyrin repeat domain-containing protein 26 - Mus musculus (Mouse) - Ankrd26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000170.1.102 Q9Y2I6 NINL_HUMAN 64.211 0.545455 0.238784 NINL - Ninein-like protein - Homo sapiens (Human) - NINL gene Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. Taurus_UMD|evm.model.AC_000170.1.103 A6NC57 ANR62_HUMAN 58.607 0.31436 0.842966 ANKRD62 - Ankyrin repeat domain-containing protein 62 - Homo sapiens (Human) - ANKRD62 gene Taurus_UMD|evm.model.AC_000170.1.105 Q9UPS8 ANR26_HUMAN 61.538 0.941176 0.0596491 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000170.1.106 Q9UPS8 ANR26_HUMAN 71.437 0.998824 0.994152 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000170.1.107 O88967 YMEL1_MOUSE 94.406 0.997207 1.0014 Yme1l1 - ATP-dependent zinc metalloprotease YME1L1 - Mus musculus (Mouse) - Yme1l1 gene ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (By similarity). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure (PubMed:17709429, PubMed:24616225, PubMed:26785494, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (By similarity). Required for normal, constitutive degradation of PRELID1 (PubMed:26785494). Catalyzes the degradation of OMA1 in response to membrane depolarization. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (By similarity). Taurus_UMD|evm.model.AC_000170.1.108 E1BFR5 GWL_BOVIN 99.212 0.997745 1.00453 MASTL - Serine/threonine-protein kinase greatwall - Bos taurus (Bovine) - MASTL gene Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity). Taurus_UMD|evm.model.AC_000170.1.109 P07106 ACBD5_BOVIN 97.373 0.996176 0.981238 ACBD5 - Acyl-CoA-binding domain-containing protein 5 - Bos taurus (Bovine) - ACBD5 gene Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity). Taurus_UMD|evm.model.AC_000170.1.110 Q9QZM5 ABI1_RAT 98.529 0.995807 1.0021 Abi1 - Abl interactor 1 - Rattus norvegicus (Rat) - Abi1 gene May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. Taurus_UMD|evm.model.AC_000170.1.111 Q5T2R2 DPS1_HUMAN 85.036 0.995227 1.00964 PDSS1 - All trans-polyprenyl-diphosphate synthase PDSS1 - Homo sapiens (Human) - PDSS1 gene Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone (PubMed:16262699). Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9)and ubiquinone-10 (Q10) respectively (PubMed:16262699). The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry (PubMed:16262699). Taurus_UMD|evm.model.AC_000170.1.112 Q8PJY5 SELO_XANAC 42.717 0.974903 1 selO - Protein adenylyltransferase SelO - Xanthomonas axonopodis pv. citri (strain 306) - selO gene Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). Taurus_UMD|evm.model.AC_000170.1.113 Q7Z5R6 AB1IP_HUMAN 86.081 0.578275 1.40991 APBB1IP - Amyloid beta A4 precursor protein-binding family B member 1-interacting protein - Homo sapiens (Human) - APBB1IP gene Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. Taurus_UMD|evm.model.AC_000170.1.115 Q8ND76 CCNY_HUMAN 98.534 0.994152 1.00293 CCNY - Cyclin-Y - Homo sapiens (Human) - CCNY gene Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. Taurus_UMD|evm.model.AC_000170.1.116 B6SEH8 ERVV1_HUMAN 40.239 0.98374 0.515723 ERVV-1 - Endogenous retrovirus group V member 1 Env polyprotein precursor - Homo sapiens (Human) - ERVV-1 gene Taurus_UMD|evm.model.AC_000170.1.117 P79145 CREM_CANLF 96.389 0.879902 1.13333 CREM - cAMP-responsive element modulator - Canis lupus familiaris (Dog) - CREM gene Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform Tau is a transcriptional activator. Plays a role in spermatogenesis and is involved in spermatid maturation (By similarity). Taurus_UMD|evm.model.AC_000170.1.119 Q5RAK6 EST1A_PONAB 98.413 0.794872 0.0549683 SMG6 - Telomerase-binding protein EST1A - Pongo abelii (Sumatran orangutan) - SMG6 gene Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). Taurus_UMD|evm.model.AC_000170.1.120 Q5RCF3 CUL2_PONAB 99.597 0.997319 1.00134 CUL2 - Cullin-2 - Pongo abelii (Sumatran orangutan) - CUL2 gene Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (By similarity). Taurus_UMD|evm.model.AC_000170.1.121 Q9D4H8 CUL2_MOUSE 70.093 0.93578 0.146309 Cul2 - Cullin-2 - Mus musculus (Mouse) - Cul2 gene Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (By similarity). Taurus_UMD|evm.model.AC_000170.1.122 Q02372 NDUB8_BOVIN 98.276 0.982759 0.311828 NDUFB8 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor - Bos taurus (Bovine) - NDUFB8 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000170.1.123 Q8TEW0 PARD3_HUMAN 91.673 0.990868 0.969027 PARD3 - Partitioning defective 3 homolog - Homo sapiens (Human) - PARD3 gene Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). Taurus_UMD|evm.model.AC_000170.1.124 P13706 GPDA_DROME 65.854 0.188679 0.584022 Gpdh1 - Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic - Drosophila melanogaster (Fruit fly) - Gpdh1 gene cytosol, M band, Z disc, glycerol-3-phosphate dehydrogenase [NAD+] activity, ethanol metabolic process, flight behavior, glycerol-3-phosphate metabolic process, NADH metabolic process, NADH oxidation, response to hyperoxia Taurus_UMD|evm.model.AC_000170.1.128 O14786 NRP1_HUMAN 95.125 0.997835 1.00108 NRP1 - Neuropilin-1 precursor - Homo sapiens (Human) - NRP1 gene Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed:9288753, PubMed:9529250, PubMed:10688880). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed:19805273). It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed:9288753, PubMed:9529250, PubMed:10688880, PubMed:19805273). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799). Taurus_UMD|evm.model.AC_000170.1.129 P53712 ITB1_BOVIN 100.000 0.864425 1.15539 ITGB1 - Integrin beta-1 precursor - Bos taurus (Bovine) - ITGB1 gene Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (By similarity). ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (By similarity). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity). Taurus_UMD|evm.model.AC_000170.1.130 Q96M83 CCDC7_HUMAN 32.995 0.349321 0.797834 CCDC7 - Coiled-coil domain-containing protein 7 - Homo sapiens (Human) - CCDC7 gene May play a role in tumorigenesis. Taurus_UMD|evm.model.AC_000170.1.131 Q96M83 CCDC7_HUMAN 68.323 0.983607 0.352347 CCDC7 - Coiled-coil domain-containing protein 7 - Homo sapiens (Human) - CCDC7 gene May play a role in tumorigenesis. Taurus_UMD|evm.model.AC_000170.1.132 Q9D4P0 ARL5B_MOUSE 100.000 0.983425 1.01117 Arl5b - ADP-ribosylation factor-like protein 5B - Mus musculus (Mouse) - Arl5b gene Binds and exchanges GTP and GDP. Taurus_UMD|evm.model.AC_000170.1.133 Q5VYJ5 MALR1_HUMAN 60.708 0.972154 0.566327 MALRD1 - MAM and LDL-receptor class A domain-containing protein 1 precursor - Homo sapiens (Human) - MALRD1 gene Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis. Taurus_UMD|evm.model.AC_000170.1.134 Q5VYJ5 MALR1_HUMAN 67.742 0.788079 0.0700371 MALRD1 - MAM and LDL-receptor class A domain-containing protein 1 precursor - Homo sapiens (Human) - MALRD1 gene Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis. Taurus_UMD|evm.model.AC_000170.1.135 Q5VYJ5 MALR1_HUMAN 81.122 0.730337 0.12384 MALRD1 - MAM and LDL-receptor class A domain-containing protein 1 precursor - Homo sapiens (Human) - MALRD1 gene Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis. Taurus_UMD|evm.model.AC_000170.1.137 Q6UX71 PXDC2_HUMAN 93.725 0.939048 0.992439 PLXDC2 - Plexin domain-containing protein 2 precursor - Homo sapiens (Human) - PLXDC2 gene May play a role in tumor angiogenesis. Taurus_UMD|evm.model.AC_000170.1.139 O76041 NEBL_HUMAN 90.107 0.897106 0.920118 NEBL - Nebulette - Homo sapiens (Human) - NEBL gene Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed:27733623). Isoform 2 might play a role in the assembly of focal adhesion (PubMed:15004028). Taurus_UMD|evm.model.AC_000170.1.140 Q9DC07 LNEBL_MOUSE 100.000 0.512195 0.455556 Nebl - LIM zinc-binding domain-containing Nebulette - Mus musculus (Mouse) - Nebl gene Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion (By similarity). Taurus_UMD|evm.model.AC_000170.1.141 P62278 RS13_RAT 98.667 0.980263 1.00662 Rps13 - 40S ribosomal protein S13 - Rattus norvegicus (Rat) - Rps13 gene cytosolic small ribosomal subunit, nucleolus, nucleus, postsynaptic density, synapse, 5.8S rRNA binding, mRNA 5'-UTR binding, mRNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome Taurus_UMD|evm.model.AC_000170.1.142 Q1XH10 SKDA1_HUMAN 100.000 0.449153 0.259912 SKIDA1 - SKI/DACH domain-containing protein 1 - Homo sapiens (Human) - SKIDA1 gene Taurus_UMD|evm.model.AC_000170.1.144 P55197 AF10_HUMAN 100.000 0.985075 0.250936 MLLT10 - Protein AF-10 - Homo sapiens (Human) - MLLT10 gene Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). Taurus_UMD|evm.model.AC_000170.1.145 P55197 AF10_HUMAN 91.815 0.840361 0.310861 MLLT10 - Protein AF-10 - Homo sapiens (Human) - MLLT10 gene Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). Taurus_UMD|evm.model.AC_000170.1.146 P55197 AF10_HUMAN 92.830 0.996234 0.497191 MLLT10 - Protein AF-10 - Homo sapiens (Human) - MLLT10 gene Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). Taurus_UMD|evm.model.AC_000170.1.147 Q96KC8 DNJC1_HUMAN 78.085 0.6874 1.13177 DNAJC1 - DnaJ homolog subfamily C member 1 precursor - Homo sapiens (Human) - DNAJC1 gene May modulate protein synthesis. Taurus_UMD|evm.model.AC_000170.1.148 P82539 DNJC1_CANLF 95.000 0.202128 4.7 DNAJC1 - DnaJ homolog subfamily C member 1 - Canis lupus familiaris (Dog) - DNAJC1 gene Taurus_UMD|evm.model.AC_000170.1.149 Q5E995 RS6_BOVIN 93.785 0.911917 0.7751 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Taurus_UMD|evm.model.AC_000170.1.150 P62902 RL31_RAT 59.375 0.964706 0.68 Rpl31 - 60S ribosomal protein L31 - Rattus norvegicus (Rat) - Rpl31 gene cytosolic large ribosomal subunit, nucleolus, nucleoplasm, polysomal ribosome, synapse, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000170.1.151 Q32KX7 BMI1_BOVIN 100.000 0.993884 1.00307 BMI1 - Polycomb complex protein BMI-1 - Bos taurus (Bovine) - BMI1 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. Taurus_UMD|evm.model.AC_000170.1.152 Q9JLI7 SPAG6_MOUSE 97.002 0.974895 0.942801 Spag6 - Sperm-associated antigen 6 - Mus musculus (Mouse) - Spag6 gene Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. Taurus_UMD|evm.model.AC_000170.1.154 O88377 PI42B_RAT 89.855 0.202985 0.805288 Pip4k2b - Phosphatidylinositol 5-phosphate 4-kinase type-2 beta - Rattus norvegicus (Rat) - Pip4k2b gene Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:9685379). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation (By similarity). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (By similarity). Taurus_UMD|evm.model.AC_000170.1.155 Q5W041 ARMC3_HUMAN 86.384 0.971942 1.02179 ARMC3 - Armadillo repeat-containing protein 3 - Homo sapiens (Human) - ARMC3 gene extracellular exosome Taurus_UMD|evm.model.AC_000170.1.156 Q9Y3D2 MSRB2_HUMAN 83.234 0.907104 1.00549 MSRB2 - Methionine-R-sulfoxide reductase B2, mitochondrial precursor - Homo sapiens (Human) - MSRB2 gene Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. Taurus_UMD|evm.model.AC_000170.1.157 Q7RTS3 PTF1A_HUMAN 90.854 0.993789 0.981707 PTF1A - Pancreas transcription factor 1 subunit alpha - Homo sapiens (Human) - PTF1A gene Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. Taurus_UMD|evm.model.AC_000170.1.158 Q8IYJ2 CJ067_HUMAN 61.434 0.969524 0.952813 C10orf67 - Uncharacterized protein C10orf67, mitochondrial precursor - Homo sapiens (Human) - C10orf67 gene Taurus_UMD|evm.model.AC_000170.1.159 Q5VV17 OTUD1_HUMAN 87.810 0.995851 1.00208 OTUD1 - OTU domain-containing protein 1 - Homo sapiens (Human) - OTUD1 gene Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin. Taurus_UMD|evm.model.AC_000170.1.161 Q5T5P2 SKT_HUMAN 79.754 0.998937 0.968091 KIAA1217 - Sickle tail protein homolog - Homo sapiens (Human) - KIAA1217 gene Required for normal development of intervertebral disks. Taurus_UMD|evm.model.AC_000170.1.162 Q5T5U3 RHG21_HUMAN 86.121 0.998975 0.996936 ARHGAP21 - Rho GTPase-activating protein 21 - Homo sapiens (Human) - ARHGAP21 gene Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. Taurus_UMD|evm.model.AC_000170.1.163 Q6DCP3 PRDC1_XENLA 52.252 0.382671 1.23661 prtfdc1 - Phosphoribosyltransferase domain-containing protein 1 - Xenopus laevis (African clawed frog) - prtfdc1 gene Taurus_UMD|evm.model.AC_000170.1.164 Q9NRG1 PRDC1_HUMAN 91.753 0.432432 0.986667 PRTFDC1 - Phosphoribosyltransferase domain-containing protein 1 - Homo sapiens (Human) - PRTFDC1 gene Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage. Taurus_UMD|evm.model.AC_000170.1.165 Q8TC29 ENKUR_HUMAN 89.370 0.973077 1.01562 ENKUR - Enkurin - Homo sapiens (Human) - ENKUR gene Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel. Taurus_UMD|evm.model.AC_000170.1.166 Q9BH05 THNS1_MACFA 91.117 0.990654 1.00808 THNSL1 - Threonine synthase-like 1 - Macaca fascicularis (Crab-eating macaque) - THNSL1 gene Taurus_UMD|evm.model.AC_000170.1.167 E1BBQ2 GP158_BOVIN 100.000 0.997517 0.993421 GPR158 - Probable G-protein coupled receptor 158 precursor - Bos taurus (Bovine) - GPR158 gene Orphan receptor. Taurus_UMD|evm.model.AC_000170.1.169 Q8NEV4 MYO3A_HUMAN 82.165 0.998077 0.965347 MYO3A - Myosin-IIIa - Homo sapiens (Human) - MYO3A gene Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (PubMed:12032315). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity). Taurus_UMD|evm.model.AC_000170.1.170 P48321 DCE2_PIG 98.291 0.996587 1.00171 GAD2 - Glutamate decarboxylase 2 - Sus scrofa (Pig) - GAD2 gene Catalyzes the production of GABA. Taurus_UMD|evm.model.AC_000170.1.171 Q9N0B3 CXD4_MACFA 56.105 0.970149 0.905405 GJD4 - Gap junction delta-4 protein - Macaca fascicularis (Crab-eating macaque) - GJD4 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Taurus_UMD|evm.model.AC_000170.1.172 Q9H461 FZD8_HUMAN 98.667 0.395225 0.543228 FZD8 - Frizzled-8 precursor - Homo sapiens (Human) - FZD8 gene Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. Taurus_UMD|evm.model.AC_000170.1.173 Q7YS99 OPTN_PIG 92.160 0.996516 1 OPTN - Optineurin - Sus scrofa (Pig) - OPTN gene Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. Taurus_UMD|evm.model.AC_000170.1.174 Q7L590 MCM10_HUMAN 82.171 0.997704 0.995429 MCM10 - Protein MCM10 homolog - Homo sapiens (Human) - MCM10 gene Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359). Taurus_UMD|evm.model.AC_000170.1.175 Q8WVF2 UCMA_HUMAN 77.049 0.967742 0.898551 UCMA - Unique cartilage matrix-associated protein precursor - Homo sapiens (Human) - UCMA gene May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. Taurus_UMD|evm.model.AC_000170.1.176 O18778 PAHX_BOVIN 99.379 0.476969 1.99703 PHYH - Phytanoyl-CoA dioxygenase, peroxisomal precursor - Bos taurus (Bovine) - PHYH gene Catalyzes the 2-hydroxylation of not only racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA, but also a variety of other mono- branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms) (By similarity). Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl-and 4-methyl-branched acyl-CoAs (By similarity). Taurus_UMD|evm.model.AC_000170.1.177 Q0VC82 SPS1_BOVIN 100.000 0.994911 1.00255 SEPHS1 - Selenide, water dikinase 1 - Bos taurus (Bovine) - SEPHS1 gene Synthesizes selenophosphate from selenide and ATP. Taurus_UMD|evm.model.AC_000170.1.178 Q8N7W2 BEND7_HUMAN 90.710 0.957895 0.732177 BEND7 - BEN domain-containing protein 7 - Homo sapiens (Human) - BEND7 gene extracellular exosome Taurus_UMD|evm.model.AC_000170.1.179 Q8N7W2 BEND7_HUMAN 91.667 0.303226 0.298651 BEND7 - BEN domain-containing protein 7 - Homo sapiens (Human) - BEND7 gene extracellular exosome Taurus_UMD|evm.model.AC_000170.1.180 Q2HJ41 PRP18_BOVIN 100.000 0.994169 1.00292 PRPF18 - Pre-mRNA-splicing factor 18 - Bos taurus (Bovine) - PRPF18 gene Participates in the second step of pre-mRNA splicing. Taurus_UMD|evm.model.AC_000170.1.181 Q9P2Q2 FRM4A_HUMAN 90.855 0.978506 0.940327 FRMD4A - FERM domain-containing protein 4A - Homo sapiens (Human) - FRMD4A gene Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). Taurus_UMD|evm.model.AC_000170.1.182 Q2KI00 F107B_BOVIN 99.237 0.550847 1.80153 FAM107B - Protein FAM107B - Bos taurus (Bovine) - FAM107B gene Taurus_UMD|evm.model.AC_000170.1.185 Q49AH0 CDNF_HUMAN 87.701 0.989362 1.00535 CDNF - Cerebral dopamine neurotrophic factor precursor - Homo sapiens (Human) - CDNF gene Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity). Taurus_UMD|evm.model.AC_000170.1.186 Q2YDD0 HSP7E_BOVIN 100.000 0.685714 0.206287 HSPA14 - Heat shock 70 kDa protein 14 - Bos taurus (Bovine) - HSPA14 gene Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity). Taurus_UMD|evm.model.AC_000170.1.187 Q2YDD0 HSP7E_BOVIN 99.544 0.555133 1.5501 HSPA14 - Heat shock 70 kDa protein 14 - Bos taurus (Bovine) - HSPA14 gene Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity). Taurus_UMD|evm.model.AC_000170.1.188 Q32PH7 SUV92_BOVIN 100.000 0.995134 1.00244 SUV39H2 - Histone-lysine N-methyltransferase SUV39H2 - Bos taurus (Bovine) - SUV39H2 gene Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity). Taurus_UMD|evm.model.AC_000170.1.189 Q5R6Z9 DCR1C_PONAB 83.259 0.943899 1.03035 DCLRE1C - Protein artemis - Pongo abelii (Sumatran orangutan) - DCLRE1C gene Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation, and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (By similarity). Taurus_UMD|evm.model.AC_000170.1.190 Q32LI5 MEIG1_BOVIN 100.000 0.776786 1.27273 MEIG1 - Meiosis expressed gene 1 protein homolog - Bos taurus (Bovine) - MEIG1 gene Essential for spermiogenesis. Taurus_UMD|evm.model.AC_000170.1.191 Q8R197 SAST_MOUSE 52.290 0.842697 1.00755 Olah - S-acyl fatty acid synthase thioesterase, medium chain - Mus musculus (Mouse) - Olah gene Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16). Taurus_UMD|evm.model.AC_000170.1.192 Q3SZF0 ACBD7_BOVIN 100.000 0.977528 1.01136 ACBD7 - Acyl-CoA-binding domain-containing protein 7 - Bos taurus (Bovine) - ACBD7 gene Binds medium- and long-chain acyl-CoA esters. Taurus_UMD|evm.model.AC_000170.1.193 Q32LC1 RPP38_BOVIN 100.000 0.992933 1.00355 RPP38 - Ribonuclease P protein subunit p38 - Bos taurus (Bovine) - RPP38 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Taurus_UMD|evm.model.AC_000170.1.194 Q9N181 NMT2_BOVIN 100.000 0.995992 1.00201 NMT2 - Glycylpeptide N-tetradecanoyltransferase 2 - Bos taurus (Bovine) - NMT2 gene Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Taurus_UMD|evm.model.AC_000170.1.195 Q5VUB5 F1711_HUMAN 80.137 0.986395 0.165169 FAM171A1 - Protein FAM171A1 precursor - Homo sapiens (Human) - FAM171A1 gene Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. Taurus_UMD|evm.model.AC_000170.1.196 Q5VUB5 F1711_HUMAN 90.612 0.890724 0.88427 FAM171A1 - Protein FAM171A1 precursor - Homo sapiens (Human) - FAM171A1 gene Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. Taurus_UMD|evm.model.AC_000170.1.198 P53708 ITA8_HUMAN 78.928 0.997833 0.868297 ITGA8 - Integrin alpha-8 precursor - Homo sapiens (Human) - ITGA8 gene Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. Taurus_UMD|evm.model.AC_000170.1.199 Q0IIH8 MINY3_BOVIN 100.000 0.995516 1.00225 MINDY3 - Ubiquitin carboxyl-terminal hydrolase MINDY-3 - Bos taurus (Bovine) - MINDY3 gene Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. Taurus_UMD|evm.model.AC_000170.1.201 A6QLJ8 PTER_BOVIN 100.000 0.994286 1.00287 PTER - Phosphotriesterase-related protein - Bos taurus (Bovine) - PTER gene Taurus_UMD|evm.model.AC_000170.1.202 Q9ESN4 C1QL3_MOUSE 100.000 0.992188 1.00392 C1ql3 - Complement C1q-like protein 3 precursor - Mus musculus (Mouse) - C1ql3 gene May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC1 and PCK1 and hence decreases de novo glucose production. Taurus_UMD|evm.model.AC_000170.1.204 Q5E9C0 RSU1_BOVIN 100.000 0.992806 1.00361 RSU1 - Ras suppressor protein 1 - Bos taurus (Bovine) - RSU1 gene Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro (By similarity). Taurus_UMD|evm.model.AC_000170.1.205 F1RWC3 CUBN_PIG 73.972 0.999412 0.938759 CUBN - Cubilin precursor - Sus scrofa (Pig) - CUBN gene Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. Taurus_UMD|evm.model.AC_000170.1.206 Q7YS61 TRDMT_BOVIN 100.000 0.994898 1.00256 TRDMT1 - tRNA (cytosine(38)-C(5))-methyltransferase - Bos taurus (Bovine) - TRDMT1 gene Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). Taurus_UMD|evm.model.AC_000170.1.207 P48616 VIME_BOVIN 100.000 0.995717 1.00215 VIM - Vimentin - Bos taurus (Bovine) - VIM gene Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Taurus_UMD|evm.model.AC_000170.1.208 P61648 SIA8F_PANTR 81.658 0.994987 1.00251 ST8SIA6 - Alpha-2,8-sialyltransferase 8F - Pan troglodytes (Chimpanzee) - ST8SIA6 gene Alpha-2,8-sialyltransferase that prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups. Taurus_UMD|evm.model.AC_000170.1.210 Q9N1R5 HACD1_SHEEP 98.958 0.99308 1.00347 HACD1 - Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 - Ovis aries (Sheep) - HACD1 gene Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Taurus_UMD|evm.model.AC_000170.1.211 Q92783 STAM1_HUMAN 92.442 0.953271 0.990741 STAM - Signal transducing adapter molecule 1 - Homo sapiens (Human) - STAM gene Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Taurus_UMD|evm.model.AC_000170.1.212 Q05005 TM236_RABIT 72.493 0.991453 1 TMEM236 - Transmembrane protein 236 - Oryctolagus cuniculus (Rabbit) - TMEM236 gene Taurus_UMD|evm.model.AC_000170.1.213 P22897 MRC1_HUMAN 86.745 0.998626 1 MRC1 - Macrophage mannose receptor 1 precursor - Homo sapiens (Human) - MRC1 gene Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Taurus_UMD|evm.model.AC_000170.1.214 Q08E40 S39AC_BOVIN 100.000 0.996947 1.00153 SLC39A12 - Zinc transporter ZIP12 - Bos taurus (Bovine) - SLC39A12 gene Acts as a zinc-influx transporter. Taurus_UMD|evm.model.AC_000170.1.215 Q9MZL5 CACB2_BOVIN 99.661 0.893778 1.09287 CACNB2 - Voltage-dependent L-type calcium channel subunit beta-2 - Bos taurus (Bovine) - CACNB2 gene The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Taurus_UMD|evm.model.AC_000170.1.216 Q8TEA1 NSUN6_HUMAN 86.567 0.993631 1.00426 NSUN6 - tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 - Homo sapiens (Human) - NSUN6 gene S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA) (PubMed:26160102, PubMed:27703015, PubMed:28531330). In vitro also methylates tRNA(Thr)(AGT) (PubMed:27703015, PubMed:26160102). Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates (PubMed:26160102, PubMed:27703015). Taurus_UMD|evm.model.AC_000170.1.217 Q9H2F5 EPC1_HUMAN 93.182 0.997543 0.973684 EPC1 - Enhancer of polycomb homolog 1 - Homo sapiens (Human) - EPC1 gene Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Taurus_UMD|evm.model.AC_000170.1.218 P33176 KINH_HUMAN 98.339 0.997925 1.00104 KIF5B - Kinesin-1 heavy chain - Homo sapiens (Human) - KIF5B gene Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Taurus_UMD|evm.model.AC_000170.1.219 Q8IWW6 RHG12_HUMAN 91.124 0.997622 0.99409 ARHGAP12 - Rho GTPase-activating protein 12 - Homo sapiens (Human) - ARHGAP12 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000170.1.221 P37275 ZEB1_HUMAN 87.170 0.998227 1.00356 ZEB1 - Zinc finger E-box-binding homeobox 1 - Homo sapiens (Human) - ZEB1 gene Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Taurus_UMD|evm.model.AC_000170.1.223 Q7Z4V0 ZN438_HUMAN 57.791 0.950057 1.06401 ZNF438 - Zinc finger protein 438 - Homo sapiens (Human) - ZNF438 gene Isoform 1 acts as a transcriptional repressor. Taurus_UMD|evm.model.AC_000170.1.224 O46385 SVIL_BOVIN 97.843 0.920095 0.764357 SVIL - Supervillin - Bos taurus (Bovine) - SVIL gene Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (By similarity). Taurus_UMD|evm.model.AC_000170.1.228 A2VE02 JCAD_BOVIN 100.000 0.998262 0.881992 JCAD - Junctional protein associated with coronary artery disease homolog - Bos taurus (Bovine) - JCAD gene adherens junction, ruffle membrane, positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Taurus_UMD|evm.model.AC_000170.1.229 A2VE02 JCAD_BOVIN 100.000 0.981651 0.0835249 JCAD - Junctional protein associated with coronary artery disease homolog - Bos taurus (Bovine) - JCAD gene adherens junction, ruffle membrane, positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Taurus_UMD|evm.model.AC_000170.1.230 Q9NVV4 PAPD1_HUMAN 80.171 0.996575 1.00344 MTPAP - Poly(A) RNA polymerase, mitochondrial precursor - Homo sapiens (Human) - MTPAP gene Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA. Taurus_UMD|evm.model.AC_000170.1.231 P41279 M3K8_HUMAN 96.154 0.896353 1.11563 MAP3K8 - Mitogen-activated protein kinase kinase kinase 8 - Homo sapiens (Human) - MAP3K8 gene Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant. Taurus_UMD|evm.model.AC_000170.1.232 A0JNM6 LYZL1_BOVIN 100.000 0.986577 1.00676 LYZL1 - Lysozyme-like protein 1 precursor - Bos taurus (Bovine) - LYZL1 gene Taurus_UMD|evm.model.AC_000170.1.233 Q8HYZ0 BAMBI_SHEEP 98.846 0.992337 1.00385 BAMBI - BMP and activin membrane-bound inhibitor homolog precursor - Ovis aries (Sheep) - BAMBI gene Negatively regulates TGF-beta signaling. Taurus_UMD|evm.model.AC_000170.1.235 Q9BTA9 WAC_HUMAN 97.134 0.97205 0.995363 WAC - WW domain-containing adapter protein with coiled-coil - Homo sapiens (Human) - WAC gene Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). Taurus_UMD|evm.model.AC_000170.1.236 A6QQZ7 MPP7_BOVIN 100.000 0.996534 1.00174 MPP7 - MAGUK p55 subfamily member 7 - Bos taurus (Bovine) - MPP7 gene Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity). Taurus_UMD|evm.model.AC_000170.1.237 Q5T2S8 ODAD2_HUMAN 76.759 0.990899 0.841954 ODAD2 - Outer dynein arm-docking complex subunit 2 - Homo sapiens (Human) - ODAD2 gene Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule (By similarity). May be involved in a late step of axonemal outer dynein arm assembly (PubMed:23849778). Taurus_UMD|evm.model.AC_000170.1.238 Q8IYA7 MKX_HUMAN 95.170 0.994334 1.00284 MKX - Homeobox protein Mohawk - Homo sapiens (Human) - MKX gene May act as a morphogenetic regulator of cell adhesion. Taurus_UMD|evm.model.AC_000170.1.239 Q0IIG8 RAB18_BOVIN 100.000 0.87234 1.14078 RAB18 - Ras-related protein Rab-18 precursor - Bos taurus (Bovine) - RAB18 gene Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (By similarity). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (By similarity). Taurus_UMD|evm.model.AC_000170.1.240 Q0EEE2 PTHD3_MOUSE 32.105 0.97561 0.135762 Ptchd3 - Patched domain-containing protein 3 - Mus musculus (Mouse) - Ptchd3 gene May play a role in sperm development or sperm function. Taurus_UMD|evm.model.AC_000170.1.241 Q9UPS8 ANR26_HUMAN 56.304 0.792905 0.609942 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000170.1.242 A6NC57 ANR62_HUMAN 60.714 0.298925 0.507088 ANKRD62 - Ankyrin repeat domain-containing protein 62 - Homo sapiens (Human) - ANKRD62 gene Taurus_UMD|evm.model.AC_000170.1.243 Q9GLR0 NEC2_BOVIN 94.179 0.997019 1.05172 PCSK2 - Neuroendocrine convertase 2 precursor - Bos taurus (Bovine) - PCSK2 gene Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). Taurus_UMD|evm.model.AC_000170.1.244 Q8N4L8 CCD24_HUMAN 69.444 0.794643 0.729642 CCDC24 - Coiled-coil domain-containing protein 24 - Homo sapiens (Human) - CCDC24 gene Taurus_UMD|evm.model.AC_000170.1.245 Q28039 SC6A9_BOVIN 83.127 0.934402 1.07524 SLC6A9 - Sodium- and chloride-dependent glycine transporter 1 - Bos taurus (Bovine) - SLC6A9 gene Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission (By similarity). Taurus_UMD|evm.model.AC_000170.1.246 Q06002 BFSP1_BOVIN 99.868 0.997361 1.00132 BFSP1 - Filensin - Bos taurus (Bovine) - BFSP1 gene Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). Involved in altering the calcium regulation of MIP water permeability (By similarity). Taurus_UMD|evm.model.AC_000170.1.247 P60982 DEST_PIG 100.000 0.987952 1.00606 DSTN - Destrin - Sus scrofa (Pig) - DSTN gene Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. Taurus_UMD|evm.model.AC_000170.1.248 Q9P2E9 RRBP1_HUMAN 81.138 0.375465 1.14468 RRBP1 - Ribosome-binding protein 1 - Homo sapiens (Human) - RRBP1 gene Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. Taurus_UMD|evm.model.AC_000170.1.249 Q32PE7 BAFL_BOVIN 100.000 0.978022 1.01111 BANF2 - Barrier-to-autointegration factor-like protein - Bos taurus (Bovine) - BANF2 gene May play a role in BANF1 regulation and influence tissue-specific roles of BANF1. Taurus_UMD|evm.model.AC_000170.1.250 Q3ZBM5 SNX5_BOVIN 100.000 0.995062 1.00248 SNX5 - Sorting nexin-5 - Bos taurus (Bovine) - SNX5 gene Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol lipids. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde transport of lysosomal enzyme receptor IGF2R. May function as link between endosomal transport vesicles and dynactin. Plays a role in the internalization of EGFR after EGF stimulation. Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C and is retromer-independent. Together with PIP5K1C facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation. Plays a role in macropinocytosis (By similarity). Taurus_UMD|evm.model.AC_000170.1.251 Q9BQP7 MGME1_HUMAN 80.294 0.988338 0.997093 MGME1 - Mitochondrial genome maintenance exonuclease 1 - Homo sapiens (Human) - MGME1 gene Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. Taurus_UMD|evm.model.AC_000170.1.252 Q9BRP0 OVOL2_HUMAN 89.781 0.992727 1 OVOL2 - Transcription factor Ovo-like 2 - Homo sapiens (Human) - OVOL2 gene Zinc-finger transcription repressor factor (PubMed:19700410). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (PubMed:19700410). Important for the correct development of primordial germ cells in embryos (By similarity). Taurus_UMD|evm.model.AC_000170.1.253 P0DJF2 PT117_MOUSE 88.889 0.97561 1.025 Pet117 - Protein PET117 homolog, mitochondrial precursor - Mus musculus (Mouse) - Pet117 gene mitochondrion, mitochondrial cytochrome c oxidase assembly Taurus_UMD|evm.model.AC_000170.1.254 Q9H8E8 CSR2B_HUMAN 95.512 0.979367 0.929668 KAT14 - Cysteine-rich protein 2-binding protein - Homo sapiens (Human) - KAT14 gene Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle. Taurus_UMD|evm.model.AC_000170.1.255 Q9H8E8 CSR2B_HUMAN 98.276 0.647727 0.112532 KAT14 - Cysteine-rich protein 2-binding protein - Homo sapiens (Human) - KAT14 gene Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle. Taurus_UMD|evm.model.AC_000170.1.256 P52736 ZN133_HUMAN 83.439 0.957055 0.996942 ZNF133 - Zinc finger protein 133 - Homo sapiens (Human) - ZNF133 gene May be involved in transcriptional regulation as a repressor. Taurus_UMD|evm.model.AC_000170.1.257 Q9NVP4 DZAN1_HUMAN 60.795 0.842697 0.236702 DZANK1 - Double zinc ribbon and ankyrin repeat-containing protein 1 - Homo sapiens (Human) - DZANK1 gene Taurus_UMD|evm.model.AC_000170.1.258 P52736 ZN133_HUMAN 78.822 0.982677 0.970948 ZNF133 - Zinc finger protein 133 - Homo sapiens (Human) - ZNF133 gene May be involved in transcriptional regulation as a repressor. Taurus_UMD|evm.model.AC_000170.1.259 Q9NVP4 DZAN1_HUMAN 71.731 0.99169 0.960106 DZANK1 - Double zinc ribbon and ankyrin repeat-containing protein 1 - Homo sapiens (Human) - DZANK1 gene Taurus_UMD|evm.model.AC_000170.1.260 Q2T9S3 RPC6_BOVIN 99.684 0.993691 1.00316 POLR3F - DNA-directed RNA polymerase III subunit RPC6 - Bos taurus (Bovine) - POLR3F gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Preferentially binds double-stranded DNA (dsDNA) (By similarity). Taurus_UMD|evm.model.AC_000170.1.261 O88851 RBBP9_MOUSE 91.954 0.988571 0.94086 Rbbp9 - Putative hydrolase RBBP9 - Mus musculus (Mouse) - Rbbp9 gene Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1. Taurus_UMD|evm.model.AC_000170.1.262 Q3SZN2 SC23B_BOVIN 100.000 0.997396 1.0013 SEC23B - Protein transport protein Sec23B - Bos taurus (Bovine) - SEC23B gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Taurus_UMD|evm.model.AC_000170.1.263 A0A096LP01 SIM26_HUMAN 59.551 0.884211 1 SMIM26 - Small integral membrane protein 26 - Homo sapiens (Human) - SMIM26 gene Taurus_UMD|evm.model.AC_000170.1.264 Q2T9V8 DTD1_BOVIN 100.000 0.990476 1.00478 DTD1 - D-aminoacyl-tRNA deacylase 1 - Bos taurus (Bovine) - DTD1 gene An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. Taurus_UMD|evm.model.AC_000170.1.265 Q58DW5 RL5_BOVIN 98.653 0.993289 1.00337 RPL5 - 60S ribosomal protein L5 - Bos taurus (Bovine) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Taurus_UMD|evm.model.AC_000170.1.266 Q2TBS3 SCP2D_BOVIN 100.000 0.987261 1.00641 SCP2D1 - SCP2 sterol-binding domain-containing protein 1 - Bos taurus (Bovine) - SCP2D1 gene sterol binding, phospholipid transport, positive regulation of intracellular cholesterol transport, steroid biosynthetic process Taurus_UMD|evm.model.AC_000170.1.267 Q9HC58 NCKX3_HUMAN 92.869 0.995033 0.937888 SLC24A3 - Sodium/potassium/calcium exchanger 3 precursor - Homo sapiens (Human) - SLC24A3 gene Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Taurus_UMD|evm.model.AC_000170.1.268 Q86XZ4 SPAS2_HUMAN 85.224 0.994737 0.697248 SPATS2 - Spermatogenesis-associated serine-rich protein 2 - Homo sapiens (Human) - SPATS2 gene cytoplasm, cytosol, RNA binding Taurus_UMD|evm.model.AC_000170.1.269 Q8WYP3 RIN2_HUMAN 95.130 0.371671 0.922905 RIN2 - Ras and Rab interactor 2 - Homo sapiens (Human) - RIN2 gene Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. Taurus_UMD|evm.model.AC_000170.1.270 P61600 NAA20_MOUSE 100.000 0.988827 1.00562 Naa20 - N-alpha-acetyltransferase 20 - Mus musculus (Mouse) - Naa20 gene Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration. Taurus_UMD|evm.model.AC_000170.1.271 P63155 CRNL1_RAT 94.334 0.986014 1.03623 Crnkl1 - Crooked neck-like protein 1 - Rattus norvegicus (Rat) - Crnkl1 gene Involved in pre-mRNA splicing process. Taurus_UMD|evm.model.AC_000170.1.272 Q8NHU2 CFA61_HUMAN 77.222 0.498145 0.871463 CFAP61 - Cilia- and flagella-associated protein 61 - Homo sapiens (Human) - CFAP61 gene May regulate cilium motility through its role in the assembly of the axonemal radial spokes. Taurus_UMD|evm.model.AC_000170.1.273 A6H7J1 INSM1_BOVIN 100.000 0.816162 0.948276 INSM1 - Insulinoma-associated protein 1 - Bos taurus (Bovine) - INSM1 gene Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4'. Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation. Taurus_UMD|evm.model.AC_000170.1.274 Q2PPJ7 RGPA2_HUMAN 86.346 0.983511 1.00374 RALGAPA2 - Ral GTPase-activating protein subunit alpha-2 - Homo sapiens (Human) - RALGAPA2 gene Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. Taurus_UMD|evm.model.AC_000170.1.275 B2RUJ5 APBA1_MOUSE 87.179 0.463415 0.0973872 Apba1 - Amyloid-beta A4 precursor protein-binding family A member 1 - Mus musculus (Mouse) - Apba1 gene Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of AAP-beta (By similarity). Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156). Taurus_UMD|evm.model.AC_000170.1.276 A0JNH1 KIZ_BOVIN 100.000 0.997253 1.00138 KIZ - Centrosomal protein kizuna - Bos taurus (Bovine) - KIZ gene Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole (By similarity). Taurus_UMD|evm.model.AC_000170.1.277 Q9H0D6 XRN2_HUMAN 95.794 0.997899 1.00211 XRN2 - 5'-3' exoribonuclease 2 - Homo sapiens (Human) - XRN2 gene Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). Taurus_UMD|evm.model.AC_000170.1.278 Q9EQM3 NKX24_MOUSE 96.875 0.120155 0.728814 Nkx2-4 - Homeobox protein Nkx-2.4 - Mus musculus (Mouse) - Nkx2-4 gene Probable transcription factor. Taurus_UMD|evm.model.AC_000170.1.279 O95096 NKX22_HUMAN 98.168 0.992701 1.00366 NKX2-2 - Homeobox protein Nkx-2.2 - Homo sapiens (Human) - NKX2-2 gene Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). Taurus_UMD|evm.model.AC_000170.1.280 A6H767 NP1L1_BOVIN 96.447 0.994937 1.01023 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Taurus_UMD|evm.model.AC_000170.1.281 P09084 PAX1_MOUSE 92.059 0.793911 0.957399 Pax1 - Paired box protein Pax-1 - Mus musculus (Mouse) - Pax1 gene This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column. Taurus_UMD|evm.model.AC_000170.1.283 Q3U2K5 KDM4D_MOUSE 59.155 0.311881 0.396078 Kdm4d - Lysine-specific demethylase 4D - Mus musculus (Mouse) - Kdm4d gene Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Taurus_UMD|evm.model.AC_000170.1.284 Q9Y261 FOXA2_HUMAN 96.984 0.99537 0.945295 FOXA2 - Hepatocyte nuclear factor 3-beta - Homo sapiens (Human) - FOXA2 gene Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. Taurus_UMD|evm.model.AC_000170.1.285 P06579 TRBM_BOVIN 100.000 0.606218 1.6264 THBD - Thrombomodulin - Bos taurus (Bovine) - THBD gene Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Taurus_UMD|evm.model.AC_000170.1.286 Q9NPY3 C1QR1_HUMAN 70.588 0.983051 0.180982 CD93 - Complement component C1q receptor precursor - Homo sapiens (Human) - CD93 gene Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. Taurus_UMD|evm.model.AC_000170.1.287 Q9NPY3 C1QR1_HUMAN 72.112 0.996 0.766871 CD93 - Complement component C1q receptor precursor - Homo sapiens (Human) - CD93 gene Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. Taurus_UMD|evm.model.AC_000170.1.288 Q5E983 EF1B_BOVIN 96.377 0.951389 0.64 EEF1B - Elongation factor 1-beta - Bos taurus (Bovine) - EEF1B gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Taurus_UMD|evm.model.AC_000170.1.289 Q2KIW0 NXT1_BOVIN 99.286 0.665072 1.49286 NXT1 - NTF2-related export protein 1 - Bos taurus (Bovine) - NXT1 gene Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (By similarity). Taurus_UMD|evm.model.AC_000170.1.290 Q9H116 GZF1_HUMAN 82.011 0.912031 1.0872 GZF1 - GDNF-inducible zinc finger protein 1 - Homo sapiens (Human) - GZF1 gene Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. Taurus_UMD|evm.model.AC_000170.1.291 P81126 SNAB_BOVIN 100.000 0.993311 1.00336 NAPB - Beta-soluble NSF attachment protein - Bos taurus (Bovine) - NAPB gene Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Taurus_UMD|evm.model.AC_000170.1.293 Q80Y72 CSTL1_MOUSE 59.821 0.808824 0.971429 Cstl1 - Cystatin-like 1 precursor - Mus musculus (Mouse) - Cstl1 gene Taurus_UMD|evm.model.AC_000170.1.294 Q8K5A3 CST11_RAT 53.153 0.714286 1.10791 Cst11 - Cystatin-11 precursor - Rattus norvegicus (Rat) - Cst11 gene Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Taurus_UMD|evm.model.AC_000170.1.295 Q32KQ9 CST16_BOVIN 99.206 0.984252 1.00794 Probable cystatin-16 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.296 Q2NKZ5 CST15_BOVIN 100.000 0.984496 1.00781 Probable cystatin-15 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.297 O60676 CST8_HUMAN 54.815 0.917808 1.02817 CST8 - Cystatin-8 precursor - Homo sapiens (Human) - CST8 gene Performs a specialized role during sperm development and maturation. Taurus_UMD|evm.model.AC_000170.1.298 Q80ZN5 CST13_MOUSE 59.574 0.985915 1.00709 Cst13 - Cystatin-13 precursor - Mus musculus (Mouse) - Cst13 gene May perform a specialized role during sperm development and maturation. Taurus_UMD|evm.model.AC_000170.1.299 Q29RH0 CST9_BOVIN 99.346 0.980645 1.01307 CST9 - Cystatin-9 precursor - Bos taurus (Bovine) - CST9 gene May play a role in hematopoietic differentiation or inflammation. Taurus_UMD|evm.model.AC_000170.1.300 P01035 CYTC_BOVIN 100.000 0.986577 1.00676 CST3 - Cystatin-C precursor - Bos taurus (Bovine) - CST3 gene This is a thiol proteinase inhibitor. Taurus_UMD|evm.model.AC_000170.1.301 Q08DM6 SYNG1_BOVIN 100.000 0.637717 1.56202 SYNDIG1 - Synapse differentiation-inducing gene protein 1 - Bos taurus (Bovine) - SYNDIG1 gene May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation. Taurus_UMD|evm.model.AC_000170.1.302 O76096 CYTF_HUMAN 71.724 0.986301 1.0069 CST7 - Cystatin-F precursor - Homo sapiens (Human) - CST7 gene Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system. Taurus_UMD|evm.model.AC_000170.1.303 Q3T0E5 APMAP_BOVIN 100.000 0.995157 1.00243 APMAP - Adipocyte plasma membrane-associated protein - Bos taurus (Bovine) - APMAP gene Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation (By similarity). Taurus_UMD|evm.model.AC_000170.1.304 Q9GMA3 VSX1_BOVIN 100.000 0.336957 2.7726 VSX1 - Visual system homeobox 1 - Bos taurus (Bovine) - VSX1 gene Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster (By similarity). May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development (By similarity). Taurus_UMD|evm.model.AC_000170.1.306 Q3U0P5 ENTP6_MOUSE 58.333 0.627119 0.518681 Entpd6 - Ectonucleoside triphosphate diphosphohydrolase 6 - Mus musculus (Mouse) - Entpd6 gene Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP. The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Taurus_UMD|evm.model.AC_000170.1.307 Q5MIB6 PYGB_SHEEP 81.053 0.686131 0.162515 PYGB - Glycogen phosphorylase, brain form - Ovis aries (Sheep) - PYGB gene Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Taurus_UMD|evm.model.AC_000170.1.308 Q3B7M9 PYGB_BOVIN 99.701 0.982327 0.805457 PYGB - Glycogen phosphorylase, brain form - Bos taurus (Bovine) - PYGB gene Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Taurus_UMD|evm.model.AC_000170.1.309 Q08DW9 ABD12_BOVIN 100.000 0.994987 1.00251 ABHD12 - Lysophosphatidylserine lipase ABHD12 - Bos taurus (Bovine) - ABHD12 gene Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity). Taurus_UMD|evm.model.AC_000170.1.310 Q8K2I9 FBH1_MOUSE 58.065 0.564103 0.112284 Fbh1 - F-box DNA helicase 1 - Mus musculus (Mouse) - Fbh1 gene 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:24108124). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal. In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (By similarity). Taurus_UMD|evm.model.AC_000170.1.311 Q6P6B7 ANR16_HUMAN 83.149 0.97043 1.03047 ANKRD16 - Ankyrin repeat domain-containing protein 16 - Homo sapiens (Human) - ANKRD16 gene Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides. Taurus_UMD|evm.model.AC_000170.1.312 O46563 VATH_BOVIN 92.708 0.995708 0.964803 ATP6V1H - V-type proton ATPase subunit H - Bos taurus (Bovine) - ATP6V1H gene Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (By similarity). Taurus_UMD|evm.model.AC_000170.1.313 Q5RCP8 H2B2E_PONAB 84.746 0.975 0.952381 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000170.1.314 P50397 GDIB_BOVIN 100.000 0.995516 1.00225 GDI2 - Rab GDP dissociation inhibitor beta - Bos taurus (Bovine) - GDI2 gene Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Taurus_UMD|evm.model.AC_000170.1.315 Q5VWN6 TASO2_HUMAN 59.191 0.900979 1.093 TASOR2 - Protein TASOR 2 - Homo sapiens (Human) - TASOR2 gene cytosol, nucleoplasm Taurus_UMD|evm.model.AC_000170.1.316 Q8VBX0 ASB13_MOUSE 92.806 0.992832 1.0036 Asb13 - Ankyrin repeat and SOCS box protein 13 - Mus musculus (Mouse) - Asb13 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000170.1.317 Q5U206 CALL3_RAT 61.345 0.728395 1.08725 Calml3 - Calmodulin-like protein 3 - Rattus norvegicus (Rat) - Calml3 gene May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates (By similarity). Taurus_UMD|evm.model.AC_000170.1.318 P24044 CALM_PLAFA 58.219 0.966443 1 Calmodulin - Plasmodium falciparum Taurus_UMD|evm.model.AC_000170.1.319 Q9Z206 ARHG8_MOUSE 83.789 0.94041 0.902521 Net1 - Neuroepithelial cell-transforming gene 1 protein - Mus musculus (Mouse) - Net1 gene Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway. Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. Taurus_UMD|evm.model.AC_000170.1.320 Q1RMJ9 UCN3_BOVIN 99.398 0.988024 1.00602 UCN3 - Urocortin-3 precursor - Bos taurus (Bovine) - UCN3 gene Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity). Taurus_UMD|evm.model.AC_000170.1.321 A6NHL2 TBAL3_HUMAN 80.000 0.96732 1.02915 TUBAL3 - Tubulin alpha chain-like 3 - Homo sapiens (Human) - TUBAL3 gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Taurus_UMD|evm.model.AC_000170.1.322 P52898 DDBX_BOVIN 83.282 0.993827 1.0031 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.323 P52898 DDBX_BOVIN 85.065 0.971519 0.978328 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.324 P52898 DDBX_BOVIN 88.026 0.461769 2.06502 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.325 P52898 DDBX_BOVIN 84.830 0.993827 1.0031 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.326 P52898 DDBX_BOVIN 82.090 0.225424 1.82663 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.327 P52897 PGFS2_BOVIN 72.000 0.851282 0.603715 Prostaglandin F synthase 2 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.328 P52898 DDBX_BOVIN 89.164 0.993827 1.0031 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.329 P52898 DDBX_BOVIN 100.000 0.993827 1.0031 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.330 P52898 DDBX_BOVIN 89.783 0.993827 1.0031 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.331 P52898 DDBX_BOVIN 89.198 0.987768 1.01238 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.332 P52897 PGFS2_BOVIN 100.000 0.993827 1.0031 Prostaglandin F synthase 2 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.333 P52898 DDBX_BOVIN 84.848 0.870588 1.05263 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.334 P52898 DDBX_BOVIN 88.710 0.526405 1.81734 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.335 P82125 AKCL2_PIG 83.444 0.993266 0.986711 AKR1E2 - 1,5-anhydro-D-fructose reductase - Sus scrofa (Pig) - AKR1E2 gene Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. Taurus_UMD|evm.model.AC_000170.1.336 Q9DB27 MCTS1_MOUSE 96.133 0.989011 1.00552 Mcts1 - Malignant T-cell-amplified sequence 1 - Mus musculus (Mouse) - Mcts1 gene Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3 (By similarity). Taurus_UMD|evm.model.AC_000170.1.339 Q99612 KLF6_HUMAN 93.310 0.887147 1.12721 KLF6 - Krueppel-like factor 6 - Homo sapiens (Human) - KLF6 gene Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development. Taurus_UMD|evm.model.AC_000170.1.343 Q5JRX3 PREP_HUMAN 81.774 0.996128 0.996143 PITRM1 - Presequence protease, mitochondrial precursor - Homo sapiens (Human) - PITRM1 gene Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing (PubMed:10360838, PubMed:16849325, PubMed:19196155, PubMed:24931469). Has an ATP-independent activity (PubMed:16849325). Specifically cleaves peptides in the range of 5 to 65 residues (PubMed:19196155). Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (PubMed:10360838, PubMed:19196155, PubMed:24931469). Degrades the transit peptides of mitochondrial proteins after their cleavage (PubMed:19196155). Also degrades other unstructured peptides (PubMed:19196155). It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion (PubMed:16849325, PubMed:24931469). It is a highly efficient protease, at least toward amyloid-beta protein 40 (PubMed:24931469). Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently (PubMed:24931469). Taurus_UMD|evm.model.AC_000170.1.344 P47859 PFKAP_RABIT 89.796 0.987374 1.00126 PFKP - ATP-dependent 6-phosphofructokinase, platelet type - Oryctolagus cuniculus (Rabbit) - PFKP gene Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Taurus_UMD|evm.model.AC_000170.1.348 P24049 RL17_RAT 71.166 0.991736 0.657609 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000170.1.351 P52898 DDBX_BOVIN 86.786 0.657957 1.30341 Dihydrodiol dehydrogenase 3 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.352 Q9NS39 RED2_HUMAN 79.066 0.945946 1.00135 ADARB2 - Double-stranded RNA-specific editase B2 - Homo sapiens (Human) - ADARB2 gene Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA. Taurus_UMD|evm.model.AC_000170.1.354 Q5R650 WDR37_PONAB 95.556 0.995968 1.00202 WDR37 - WD repeat-containing protein 37 - Pongo abelii (Sumatran orangutan) - WDR37 gene cytoplasm, nucleus Taurus_UMD|evm.model.AC_000170.1.356 P11369 LORF2_MOUSE 44.578 0.683333 0.0936768 Pol - LINE-1 retrotransposable element ORF2 protein - Mus musculus (Mouse) - Pol gene Has a reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition. Has also an endonuclease activity that allows the introduction of nicks in the chromosomal target DNA. Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to sites of LINE-1 integration in the genome. Taurus_UMD|evm.model.AC_000170.1.357 Q1LZ95 IDI1_BOVIN 100.000 0.784722 1.26872 IDI1 - Isopentenyl-diphosphate Delta-isomerase 1 - Bos taurus (Bovine) - IDI1 gene Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Taurus_UMD|evm.model.AC_000170.1.359 Q9BZE4 NOG1_HUMAN 93.849 0.99685 1.00158 GTPBP4 - GTP-binding protein 4 - Homo sapiens (Human) - GTPBP4 gene Involved in the biogenesis of the 60S ribosomal subunit. Taurus_UMD|evm.model.AC_000170.1.360 Q6A0A2 LAR4B_MOUSE 88.889 0.195489 0.179487 Larp4b - La-related protein 4B - Mus musculus (Mouse) - Larp4b gene Stimulates mRNA translation. Taurus_UMD|evm.model.AC_000170.1.361 Q92615 LAR4B_HUMAN 81.124 0.411091 2.24797 LARP4B - La-related protein 4B - Homo sapiens (Human) - LARP4B gene Stimulates mRNA translation. Taurus_UMD|evm.model.AC_000170.1.363 Q9Y2E4 DIP2C_HUMAN 98.470 0.931184 1.03663 DIP2C - Disco-interacting protein 2 homolog C - Homo sapiens (Human) - DIP2C gene Taurus_UMD|evm.model.AC_000170.1.364 Q15326 ZMY11_HUMAN 99.003 0.996683 1.00166 ZMYND11 - Zinc finger MYND domain-containing protein 11 - Homo sapiens (Human) - ZMYND11 gene Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. Taurus_UMD|evm.model.AC_000170.1.366 P10279 PRIO_BOVIN 100.000 0.992453 1.00379 PRNP - Major prion protein precursor - Bos taurus (Bovine) - PRNP gene Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity). Taurus_UMD|evm.model.AC_000170.1.367 Q9GK16 PRND_BOVIN 99.438 0.988827 1.00562 PRND - Prion-like protein doppel precursor - Bos taurus (Bovine) - PRND gene Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Taurus_UMD|evm.model.AC_000170.1.368 P50749 RASF2_HUMAN 95.399 0.993884 1.00307 RASSF2 - Ras association domain-containing protein 2 - Homo sapiens (Human) - RASSF2 gene Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. Taurus_UMD|evm.model.AC_000170.1.369 Q9UGH3 S23A2_HUMAN 98.151 0.995392 1.00154 SLC23A2 - Solute carrier family 23 member 2 - Homo sapiens (Human) - SLC23A2 gene Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. Taurus_UMD|evm.model.AC_000170.1.371 Q5E975 TM230_BOVIN 100.000 0.983471 1.00833 TMEM230 - Transmembrane protein 230 - Bos taurus (Bovine) - TMEM230 gene Involved in trafficking and recycling of synaptic vesicles. Taurus_UMD|evm.model.AC_000170.1.372 Q3ZBW4 PCNA_BOVIN 100.000 0.992366 1.00383 PCNA - Proliferating cell nuclear antigen - Bos taurus (Bovine) - PCNA gene Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (By similarity). Taurus_UMD|evm.model.AC_000170.1.374 A0JNC1 CDS2_BOVIN 99.766 0.914163 1.04719 CDS2 - Phosphatidate cytidylyltransferase 2 - Bos taurus (Bovine) - CDS2 gene Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (By similarity). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (By similarity). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (By similarity). Taurus_UMD|evm.model.AC_000170.1.375 Q2MHN1 FRIL_FELCA 63.953 0.933333 0.514286 FTL - Ferritin light chain - Felis catus (Cat) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000170.1.376 Q3T0Q2 TMM59_BOVIN 92.901 0.99361 0.96904 TMEM59 - Transmembrane protein 59 precursor - Bos taurus (Bovine) - TMEM59 gene Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. Taurus_UMD|evm.model.AC_000170.1.377 Q8SPN1 PKR2_BOVIN 100.000 0.994805 1.0026 PROKR2 - Prokineticin receptor 2 - Bos taurus (Bovine) - PROKR2 gene Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase (By similarity). Taurus_UMD|evm.model.AC_000170.1.378 Q9NPB8 GPCP1_HUMAN 97.619 0.997028 1.00149 GPCPD1 - Glycerophosphocholine phosphodiesterase GPCPD1 - Homo sapiens (Human) - GPCPD1 gene May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity. Taurus_UMD|evm.model.AC_000170.1.379 Q9DCH4 EIF3F_MOUSE 85.597 0.775244 0.850416 Eif3f - Eukaryotic translation initiation factor 3 subunit F - Mus musculus (Mouse) - Eif3f gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Taurus_UMD|evm.model.AC_000170.1.380 Q2KIJ1 SHLD1_BOVIN 100.000 0.990338 1.00485 SHLD1 - Shieldin complex subunit 1 - Bos taurus (Bovine) - SHLD1 gene Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. Taurus_UMD|evm.model.AC_000170.1.381 P23389 SCG1_BOVIN 99.226 0.996909 1.00155 CHGB - Secretogranin-1 precursor - Bos taurus (Bovine) - CHGB gene Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. The 16 pairs of basic AA distributed throughout its sequence may be used as proteolytic cleavage sites. Taurus_UMD|evm.model.AC_000170.1.382 Q2T9V5 TRM6_BOVIN 100.000 0.995984 1.00201 TRMT6 - tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 - Bos taurus (Bovine) - TRMT6 gene Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries. Taurus_UMD|evm.model.AC_000170.1.383 E1BPX4 MCM8_BOVIN 98.077 0.997599 1.02083 MCM8 - DNA helicase MCM8 - Bos taurus (Bovine) - MCM8 gene Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Probably by regulating HR, plays a key role during gametogenesis. Stabilizes MCM9 protein. Taurus_UMD|evm.model.AC_000170.1.384 Q9UJA2 CRLS1_HUMAN 88.333 0.986799 1.00664 CRLS1 - Cardiolipin synthase (CMP-forming) - Homo sapiens (Human) - CRLS1 gene Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. Taurus_UMD|evm.model.AC_000170.1.385 Q8WUT4 LRRN4_HUMAN 64.973 0.962291 0.967568 LRRN4 - Leucine-rich repeat neuronal protein 4 precursor - Homo sapiens (Human) - LRRN4 gene May play an important role in hippocampus-dependent long-lasting memory. Taurus_UMD|evm.model.AC_000170.1.386 Q9BQL6 FERM1_HUMAN 91.728 0.99705 1.00148 FERMT1 - Fermitin family homolog 1 - Homo sapiens (Human) - FERMT1 gene Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. Taurus_UMD|evm.model.AC_000170.1.387 Q0II59 PDXK_BOVIN 73.333 0.659259 0.432692 PDXK - Pyridoxal kinase - Bos taurus (Bovine) - PDXK gene Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (By similarity). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity). Taurus_UMD|evm.model.AC_000170.1.388 O19006 BMP2_DAMDA 97.727 0.994949 1 BMP2 - Bone morphogenetic protein 2 precursor - Dama dama (Fallow deer) - BMP2 gene Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Stimulates also the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Taurus_UMD|evm.model.AC_000170.1.389 P61078 UB2D3_RAT 95.918 0.986486 1.0068 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Taurus_UMD|evm.model.AC_000170.1.390 P61078 UB2D3_RAT 95.238 0.986486 1.0068 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Taurus_UMD|evm.model.AC_000170.1.391 P61078 UB2D3_RAT 95.238 0.986486 1.0068 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Taurus_UMD|evm.model.AC_000170.1.392 P61078 UB2D3_RAT 95.918 0.986486 1.0068 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Taurus_UMD|evm.model.AC_000170.1.393 P61078 UB2D3_RAT 95.238 0.954248 1.04082 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Taurus_UMD|evm.model.AC_000170.1.395 P08548 LIN1_NYCCO 70.851 0.979123 0.380159 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Taurus_UMD|evm.model.AC_000170.1.396 Q01580 HBEGF_PIG 82.759 0.761062 0.543269 HBEGF - Proheparin-binding EGF-like growth factor precursor - Sus scrofa (Pig) - HBEGF gene Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). Taurus_UMD|evm.model.AC_000170.1.397 Q9UJM8 HAOX1_HUMAN 92.162 0.994609 1.0027 HAO1 - Hydroxyacid oxidase 1 - Homo sapiens (Human) - HAO1 gene Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. Taurus_UMD|evm.model.AC_000170.1.398 Q9H1E5 TMX4_HUMAN 61.983 0.811189 0.409742 TMX4 - Thioredoxin-related transmembrane protein 4 precursor - Homo sapiens (Human) - TMX4 gene nuclear inner membrane Taurus_UMD|evm.model.AC_000170.1.399 Q9TTM9 ADA1D_PIG 81.913 0.996479 0.994746 ADRA1D - Alpha-1D adrenergic receptor - Sus scrofa (Pig) - ADRA1D gene This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. Taurus_UMD|evm.model.AC_000170.1.400 Q9NWM0 SMOX_HUMAN 91.282 0.996587 1.05586 SMOX - Spermine oxidase - Homo sapiens (Human) - SMOX gene Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. Taurus_UMD|evm.model.AC_000170.1.401 Q9Y225 RNF24_HUMAN 89.865 0.685567 1.31081 RNF24 - RING finger protein 24 - Homo sapiens (Human) - RNF24 gene May play a role in TRPCs intracellular trafficking. Taurus_UMD|evm.model.AC_000170.1.402 Q9BZ23 PANK2_HUMAN 94.286 0.995614 0.8 PANK2 - Pantothenate kinase 2, mitochondrial precursor - Homo sapiens (Human) - PANK2 gene Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis (PubMed:15659606, PubMed:17825826, PubMed:17242360, PubMed:16272150). Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC) (PubMed:30221726). Taurus_UMD|evm.model.AC_000170.1.404 Q7Z434 MAVS_HUMAN 57.143 0.911817 1.05 MAVS - Mitochondrial antiviral-signaling protein - Homo sapiens (Human) - MAVS gene Required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:20127681, PubMed:21170385). Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:25636800, PubMed:20127681, PubMed:21170385, PubMed:20628368). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Taurus_UMD|evm.model.AC_000170.1.405 Q9NUS5 AP5S1_HUMAN 82.412 0.9801 1.005 AP5S1 - AP-5 complex subunit sigma-1 - Homo sapiens (Human) - AP5S1 gene As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862, it is required for efficient homologous recombination DNA double-strand break repair. Taurus_UMD|evm.model.AC_000170.1.406 P30305 MPIP2_HUMAN 86.403 0.996522 0.991379 CDC25B - M-phase inducer phosphatase 2 - Homo sapiens (Human) - CDC25B gene Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. Taurus_UMD|evm.model.AC_000170.1.407 P07199 CENPB_HUMAN 96.923 0.62945 1.03172 CENPB - Major centromere autoantigen B - Homo sapiens (Human) - CENPB gene Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497). May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable). Taurus_UMD|evm.model.AC_000170.1.408 Q58DA1 SPEF1_BOVIN 100.000 0.991561 1.00424 SPEF1 - Sperm flagellar protein 1 - Bos taurus (Bovine) - SPEF1 gene Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity). Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities and for ciliary localization of HYDIN and SPAG6 in ependymal cilia (By similarity). Binds actin in intestinal epithelial cells (IECs), essential for IECs survival and contributes to formation of filopodia and lamellipodia in migrating IECs (By similarity). Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (By similarity). Taurus_UMD|evm.model.AC_000170.1.410 Q2KIM1 CT027_BOVIN 100.000 0.988571 1.00575 UPF0687 protein C20orf27 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.411 Q96MM6 HS12B_HUMAN 94.461 0.997089 1.00146 HSPA12B - Heat shock 70 kDa protein 12B - Homo sapiens (Human) - HSPA12B gene Taurus_UMD|evm.model.AC_000170.1.413 Q52RN5 SODC_BOSMU 98.684 0.986928 1.00658 SOD1 - Superoxide dismutase [Cu-Zn] - Bos mutus grunniens (Wild yak) - SOD1 gene Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Taurus_UMD|evm.model.AC_000170.1.414 A7LCJ3 SN_PIG 81.337 0.998833 0.990751 SIGLEC1 - Sialoadhesin precursor - Sus scrofa (Pig) - SIGLEC1 gene Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis (By similarity). Acts as an endocytic receptor mediating clathrin dependent endocytosis. In case of porcine reproductive and respiratory syndrome virus (PRRSV), mediates virion attachment and internalization into alveolar macrophages through a clathrin-coated dependent process. Taurus_UMD|evm.model.AC_000170.1.415 Q9BZ11 ADA33_HUMAN 76.221 0.982301 0.97294 ADAM33 - Disintegrin and metalloproteinase domain-containing protein 33 precursor - Homo sapiens (Human) - ADAM33 gene integral component of membrane, metalloendopeptidase activity, zinc ion binding, proteolysis Taurus_UMD|evm.model.AC_000170.1.416 Q9JJT2 GFRA4_MOUSE 69.068 0.820789 1.07308 Gfra4 - GDNF family receptor alpha-4 precursor - Mus musculus (Mouse) - Gfra4 gene Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. Taurus_UMD|evm.model.AC_000170.1.417 O75882 ATRN_HUMAN 93.310 0.983757 0.990903 ATRN - Attractin precursor - Homo sapiens (Human) - ATRN gene Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity). Taurus_UMD|evm.model.AC_000170.1.419 Q5TEA3 CT194_HUMAN 90.909 0.998302 1.00085 DNAAF9 - Dynein axonemal assembly factor 9 - Homo sapiens (Human) - DNAAF9 gene May act as an effector for ARL3. Taurus_UMD|evm.model.AC_000170.1.420 Q8NBS3 S4A11_HUMAN 81.250 0.97219 0.968575 SLC4A11 - Sodium bicarbonate transporter-like protein 11 - Homo sapiens (Human) - SLC4A11 gene Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter. Taurus_UMD|evm.model.AC_000170.1.421 Q2KIC5 ITPA_BOVIN 100.000 0.990431 1.00481 ITPA - Inosine triphosphate pyrophosphatase - Bos taurus (Bovine) - ITPA gene Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Taurus_UMD|evm.model.AC_000170.1.422 Q1LZB0 DDRGK_BOVIN 99.681 0.993631 1.00319 DDRGK1 - DDRGK domain-containing protein 1 precursor - Bos taurus (Bovine) - DDRGK1 gene Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy). In response to endoplasmic reticulum stress, promotes recruitment of the E3 UFM1-protein ligase UFL1 to the endoplasmic reticulum membrane: in turn, UFL1 mediates ufmylation of proteins such as RPN1 and RPL26/uL24, promoting reticulophagy of endoplasmic reticulum sheets. Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability (By similarity). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis or inflammatory response (By similarity). Required for TRIP4 ufmylation, thereby regulating nuclear receptors-mediated transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B. Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (By similarity). Taurus_UMD|evm.model.AC_000170.1.423 O60299 LZTS3_HUMAN 97.478 0.954481 1.04458 LZTS3 - Leucine zipper putative tumor suppressor 3 - Homo sapiens (Human) - LZTS3 gene May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses. Taurus_UMD|evm.model.AC_000170.1.424 Q95KD0 FAKD5_MACFA 80.131 0.934889 1.06545 FASTKD5 - FAST kinase domain-containing protein 5, mitochondrial precursor - Macaca fascicularis (Crab-eating macaque) - FASTKD5 gene Plays an important role in the processing of non-canonical mitochondrial mRNA precursors. Taurus_UMD|evm.model.AC_000170.1.425 O94941 RNF37_HUMAN 87.800 0.996283 0.994455 UBOX5 - RING finger protein 37 - Homo sapiens (Human) - UBOX5 gene May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. Taurus_UMD|evm.model.AC_000170.1.426 P01180 NEU2_BOVIN 100.000 0.988024 1.00602 AVP - Vasopressin-neurophysin 2-copeptin precursor - Bos taurus (Bovine) - AVP gene Neurophysin 2 specifically binds vasopressin. Taurus_UMD|evm.model.AC_000170.1.427 P01175 NEU1_BOVIN 100.000 0.984127 1.008 OXT - Oxytocin-neurophysin 1 precursor - Bos taurus (Bovine) - OXT gene Neurophysin 1 specifically binds oxytocin. Taurus_UMD|evm.model.AC_000170.1.428 Q3SZ86 RT26_BOVIN 100.000 0.990291 1.00488 MRPS26 - 28S ribosomal protein S26, mitochondrial precursor - Bos taurus (Bovine) - MRPS26 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000170.1.429 P18433 PTPRA_HUMAN 96.010 0.982801 1.01496 PTPRA - Receptor-type tyrosine-protein phosphatase alpha precursor - Homo sapiens (Human) - PTPRA gene Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity). Taurus_UMD|evm.model.AC_000170.1.430 Q5E9L7 VPS16_BOVIN 99.762 0.997619 1.00119 VPS16 - Vacuolar protein sorting-associated protein 16 homolog - Bos taurus (Bovine) - VPS16 gene Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for recruitment of VPS33A to the HOPS complex. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B. The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG. Taurus_UMD|evm.model.AC_000170.1.431 Q9H1Q7 PED1A_HUMAN 88.767 0.857414 1.15859 PCED1A - PC-esterase domain-containing protein 1A - Homo sapiens (Human) - PCED1A gene Taurus_UMD|evm.model.AC_000170.1.432 Q8WW34 TM239_HUMAN 86.093 0.986842 0.779487 TMEM239 - Transmembrane protein 239 - Homo sapiens (Human) - TMEM239 gene Taurus_UMD|evm.model.AC_000170.1.433 Q96SM3 CPXM1_HUMAN 88.692 0.997264 0.995913 CPXM1 - Probable carboxypeptidase X1 precursor - Homo sapiens (Human) - CPXM1 gene May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity). Taurus_UMD|evm.model.AC_000170.1.434 Q9BQW3 COE4_HUMAN 97.508 0.996683 1.00166 EBF4 - Transcription factor COE4 - Homo sapiens (Human) - EBF4 gene Transcriptional factor which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Taurus_UMD|evm.model.AC_000170.1.435 O77784 IDH3B_BOVIN 97.895 0.986979 0.997403 IDH3B - Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial precursor - Bos taurus (Bovine) - IDH3B gene Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Taurus_UMD|evm.model.AC_000170.1.436 Q3SZ63 NOP56_BOVIN 99.832 0.422475 2.35906 NOP56 - Nucleolar protein 56 - Bos taurus (Bovine) - NOP56 gene Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). Taurus_UMD|evm.model.AC_000170.1.437 Q58DW4 RSMB_BOVIN 100.000 0.991701 1.00417 SNRPB - Small nuclear ribonucleoprotein-associated protein B' - Bos taurus (Bovine) - SNRPB gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). Taurus_UMD|evm.model.AC_000170.1.438 Q9D8Z2 TRIA1_MOUSE 70.833 0.47 1.31579 Triap1 - TP53-regulated inhibitor of apoptosis 1 - Mus musculus (Mouse) - Triap1 gene Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. Taurus_UMD|evm.model.AC_000170.1.439 O95932 TGM3L_HUMAN 86.648 0.973684 1.02266 TGM6 - Protein-glutamine gamma-glutamyltransferase 6 - Homo sapiens (Human) - TGM6 gene Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Taurus_UMD|evm.model.AC_000170.1.440 A6QP57 TGM3_BOVIN 99.855 0.99711 1.00145 TGM3 - Protein-glutamine gamma-glutamyltransferase E precursor - Bos taurus (Bovine) - TGM3 gene Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath (By similarity). Taurus_UMD|evm.model.AC_000170.1.441 A8D8X1 RL10_SHEEP 94.805 0.361905 0.981308 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000170.1.442 Q8TDR2 STK35_HUMAN 91.466 0.996296 1.01124 STK35 - Serine/threonine-protein kinase 35 - Homo sapiens (Human) - STK35 gene nuclear body, nucleoplasm, nucleus, protein kinase activity, protein serine/threonine kinase activity, meiotic cell cycle Taurus_UMD|evm.model.AC_000170.1.443 Q95104 PDYN_BOVIN 98.837 0.992278 1.00388 PDYN - Proenkephalin-B precursor - Bos taurus (Bovine) - PDYN gene Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Taurus_UMD|evm.model.AC_000170.1.444 O46631 SHPS1_BOVIN 95.257 0.864726 1.15415 SIRPA - Tyrosine-protein phosphatase non-receptor type substrate 1 precursor - Bos taurus (Bovine) - SIRPA gene Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). Taurus_UMD|evm.model.AC_000170.1.445 O46631 SHPS1_BOVIN 39.024 0.415966 0.940711 SIRPA - Tyrosine-protein phosphatase non-receptor type substrate 1 precursor - Bos taurus (Bovine) - SIRPA gene Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). Taurus_UMD|evm.model.AC_000170.1.446 O46631 SHPS1_BOVIN 86.614 0.425676 0.58498 SIRPA - Tyrosine-protein phosphatase non-receptor type substrate 1 precursor - Bos taurus (Bovine) - SIRPA gene Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). Taurus_UMD|evm.model.AC_000170.1.447 Q9H0H5 RGAP1_HUMAN 93.333 0.112245 0.620253 RACGAP1 - Rac GTPase-activating protein 1 - Homo sapiens (Human) - RACGAP1 gene Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. Taurus_UMD|evm.model.AC_000170.1.448 O46631 SHPS1_BOVIN 89.518 0.893401 0.778656 SIRPA - Tyrosine-protein phosphatase non-receptor type substrate 1 precursor - Bos taurus (Bovine) - SIRPA gene Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). Taurus_UMD|evm.model.AC_000170.1.449 Q6PCB6 AB17C_HUMAN 60.784 0.779736 0.68997 ABHD17C - Alpha/beta hydrolase domain-containing protein 17C - Homo sapiens (Human) - ABHD17C gene Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95. Taurus_UMD|evm.model.AC_000170.1.450 P32244 MC3R_RAT 48.905 0.981132 0.328173 Mc3r - Melanocortin receptor 3 - Rattus norvegicus (Rat) - Mc3r gene Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. Taurus_UMD|evm.model.AC_000170.1.451 P41968 MC3R_HUMAN 76.923 0.643154 0.74613 MC3R - Melanocortin receptor 3 - Homo sapiens (Human) - MC3R gene Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. Taurus_UMD|evm.model.AC_000170.1.452 Q96MD7 CI085_HUMAN 94.545 0.703226 0.865922 C9orf85 - Uncharacterized protein C9orf85 - Homo sapiens (Human) - C9orf85 gene Taurus_UMD|evm.model.AC_000170.1.453 A4IFH4 PSF1_BOVIN 100.000 0.989848 1.0051 GINS1 - DNA replication complex GINS protein PSF1 - Bos taurus (Bovine) - GINS1 gene Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. Taurus_UMD|evm.model.AC_000170.1.454 Q58CZ2 PCMD2_BOVIN 100.000 0.902256 1.10526 PCMTD2 - Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 - Bos taurus (Bovine) - PCMTD2 gene cytoplasm, protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Taurus_UMD|evm.model.AC_000170.1.455 Q01538 MYT1_HUMAN 86.667 0.954822 1.02676 MYT1 - Myelin transcription factor 1 - Homo sapiens (Human) - MYT1 gene Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. Taurus_UMD|evm.model.AC_000170.1.456 Q8MJV2 NPBW2_BOVIN 98.492 0.88 0.669643 NPBWR2 - Neuropeptides B/W receptor type 2 - Bos taurus (Bovine) - NPBWR2 gene Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity). Taurus_UMD|evm.model.AC_000170.1.457 P41146 OPRX_HUMAN 94.595 0.726378 1.37297 OPRL1 - Nociceptin receptor - Homo sapiens (Human) - OPRL1 gene G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. Taurus_UMD|evm.model.AC_000170.1.458 Q8TD35 LKAM1_HUMAN 76.684 0.835556 1.15979 LKAAEAR1 - Protein LKAAEAR1 - Homo sapiens (Human) - LKAAEAR1 gene Taurus_UMD|evm.model.AC_000170.1.459 Q08DC7 RGS19_BOVIN 100.000 0.601626 1.65471 RGS19 - Regulator of G-protein signaling 19 - Bos taurus (Bovine) - RGS19 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein (By similarity). Taurus_UMD|evm.model.AC_000170.1.460 Q148K0 TCEA2_BOVIN 88.372 0.992958 0.946667 TCEA2 - Transcription elongation factor A protein 2 - Bos taurus (Bovine) - TCEA2 gene Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity). Taurus_UMD|evm.model.AC_000170.1.461 P35713 SOX18_HUMAN 88.372 0.993377 0.786458 SOX18 - Transcription factor SOX-18 - Homo sapiens (Human) - SOX18 gene Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development. Taurus_UMD|evm.model.AC_000170.1.462 A0A1B0GTL2 CT204_HUMAN 77.540 0.872642 1.12169 C20orf204 - Uncharacterized protein C20orf204 precursor - Homo sapiens (Human) - C20orf204 gene Taurus_UMD|evm.model.AC_000170.1.463 Q2KJJ0 PRP6_BOVIN 100.000 0.997877 1.00106 PRPF6 - Pre-mRNA-processing factor 6 - Bos taurus (Bovine) - PRPF6 gene Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Taurus_UMD|evm.model.AC_000170.1.464 Q9BYL1 SAM10_HUMAN 92.079 0.990148 1.00495 SAMD10 - Sterile alpha motif domain-containing protein 10 - Homo sapiens (Human) - SAMD10 gene Taurus_UMD|evm.model.AC_000170.1.465 Q96KM6 Z512B_HUMAN 84.420 0.945493 1.06951 ZNF512B - Zinc finger protein 512B - Homo sapiens (Human) - ZNF512B gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000170.1.466 Q9NWZ5 UCKL1_HUMAN 94.545 0.996364 1.00365 UCKL1 - Uridine-cytidine kinase-like 1 - Homo sapiens (Human) - UCKL1 gene May contribute to UTP accumulation needed for blast transformation and proliferation. Taurus_UMD|evm.model.AC_000170.1.467 Q29455 DNJC5_BOVIN 100.000 0.98995 1.00505 DNAJC5 - DnaJ homolog subfamily C member 5 - Bos taurus (Bovine) - DNAJC5 gene Acts as a general chaperone in regulated exocytosis (PubMed:9395474). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). Taurus_UMD|evm.model.AC_000170.1.468 Q5RCT1 TPD54_PONAB 90.777 0.990338 1.00485 TPD52L2 - Tumor protein D54 - Pongo abelii (Sumatran orangutan) - TPD52L2 gene cytoplasm, perinuclear region of cytoplasm Taurus_UMD|evm.model.AC_000170.1.469 Q9H3Z7 ABHGB_HUMAN 87.234 0.995754 1.00426 ABHD16B - Protein ABHD16B - Homo sapiens (Human) - ABHD16B gene membrane, nucleoplasm, acylglycerol lipase activity, palmitoyl-(protein) hydrolase activity, phospholipase activity, monoacylglycerol catabolic process, phosphatidylserine catabolic process Taurus_UMD|evm.model.AC_000170.1.470 Q86UZ6 ZBT46_HUMAN 86.486 0.951456 1.04924 ZBTB46 - Zinc finger and BTB domain-containing protein 46 - Homo sapiens (Human) - ZBTB46 gene Functions as a transcriptional repressor for PRDM1. Taurus_UMD|evm.model.AC_000170.1.471 Q9NR83 S2A4R_HUMAN 67.887 0.775229 1.12661 SLC2A4RG - SLC2A4 regulator - Homo sapiens (Human) - SLC2A4RG gene Transcription factor involved in SLC2A4 and HD gene transactivation. Binds to the consensus sequence 5'-GCCGGCG-3'. Taurus_UMD|evm.model.AC_000170.1.472 Q9EQR5 LIME1_MOUSE 59.701 0.790123 1.20446 Lime1 - Lck-interacting transmembrane adapter 1 - Mus musculus (Mouse) - Lime1 gene Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. Taurus_UMD|evm.model.AC_000170.1.473 Q17QX2 ZGPAT_BOVIN 100.000 0.996109 1.00195 ZGPAT - Zinc finger CCCH-type with G patch domain-containing protein - Bos taurus (Bovine) - ZGPAT gene Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity). Taurus_UMD|evm.model.AC_000170.1.474 Q32LJ2 ARFRP_BOVIN 100.000 0.990099 1.00498 ARFRP1 - ADP-ribosylation factor-related protein 1 - Bos taurus (Bovine) - ARFRP1 gene Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Taurus_UMD|evm.model.AC_000170.1.475 O95407 TNF6B_HUMAN 78.102 0.919192 0.99 TNFRSF6B - Tumor necrosis factor receptor superfamily member 6B precursor - Homo sapiens (Human) - TNFRSF6B gene Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Taurus_UMD|evm.model.AC_000170.1.476 A4K436 RTEL1_BOVIN 100.000 0.606522 0.378289 RTEL1 - Regulator of telomere elongation helicase 1 - Bos taurus (Bovine) - RTEL1 gene ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. Taurus_UMD|evm.model.AC_000170.1.477 A4K436 RTEL1_BOVIN 98.839 0.959032 0.441612 RTEL1 - Regulator of telomere elongation helicase 1 - Bos taurus (Bovine) - RTEL1 gene ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. Taurus_UMD|evm.model.AC_000170.1.478 A4K436 RTEL1_BOVIN 99.138 0.646067 0.146382 RTEL1 - Regulator of telomere elongation helicase 1 - Bos taurus (Bovine) - RTEL1 gene ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. Taurus_UMD|evm.model.AC_000170.1.479 A4IFK9 STMN3_BOVIN 100.000 0.98895 1.00556 STMN3 - Stathmin-3 - Bos taurus (Bovine) - STMN3 gene Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. Taurus_UMD|evm.model.AC_000170.1.480 Q9UKD1 GMEB2_HUMAN 91.604 0.996276 1.01321 GMEB2 - Glucocorticoid modulatory element-binding protein 2 - Homo sapiens (Human) - GMEB2 gene Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. Taurus_UMD|evm.model.AC_000170.1.481 Q2T9Z2 FND11_BOVIN 100.000 0.994012 1.003 Fibronectin type III domain-containing protein 11 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.482 Q9H3Y6 SRMS_HUMAN 78.528 0.981818 1.01434 SRMS - Tyrosine-protein kinase Srms - Homo sapiens (Human) - SRMS gene Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907). Taurus_UMD|evm.model.AC_000170.1.483 Q13882 PTK6_HUMAN 82.151 0.993151 0.971175 PTK6 - Protein-tyrosine kinase 6 - Homo sapiens (Human) - PTK6 gene Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways. Taurus_UMD|evm.model.AC_000170.1.484 Q3ZCB6 PPDPF_BOVIN 97.345 0.965517 1 PPDPF - Pancreatic progenitor cell differentiation and proliferation factor - Bos taurus (Bovine) - PPDPF gene Probable regulator of exocrine pancreas development. Taurus_UMD|evm.model.AC_000170.1.485 Q71V39 EF1A2_RABIT 100.000 0.99569 1.00216 EEF1A2 - Elongation factor 1-alpha 2 - Oryctolagus cuniculus (Rabbit) - EEF1A2 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Taurus_UMD|evm.model.AC_000170.1.486 Q9Z351 KCNQ2_MOUSE 89.853 0.828049 1.08037 Kcnq2 - Potassium voltage-gated channel subfamily KQT member 2 - Mus musculus (Mouse) - Kcnq2 gene Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. Taurus_UMD|evm.model.AC_000170.1.487 P43681 ACHA4_HUMAN 83.917 0.996748 0.980861 CHRNA4 - Neuronal acetylcholine receptor subunit alpha-4 precursor - Homo sapiens (Human) - CHRNA4 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. Taurus_UMD|evm.model.AC_000170.1.488 Q9EPJ9 ARFG1_MOUSE 82.284 0.234195 4.39372 Arfgap1 - ADP-ribosylation factor GTPase-activating protein 1 - Mus musculus (Mouse) - Arfgap1 gene GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). Taurus_UMD|evm.model.AC_000170.1.489 Q9JMG4 NKAI4_MOUSE 70.455 0.313869 0.658654 Nkain4 - Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4 - Mus musculus (Mouse) - Nkain4 gene membrane, regulation of sodium ion transport Taurus_UMD|evm.model.AC_000170.1.490 A2AWP0 BIRC7_MOUSE 74.483 0.476821 1.05965 Birc7 - Baculoviral IAP repeat-containing protein 7 - Mus musculus (Mouse) - Birc7 gene Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of caspase-3, -7, and -9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. Taurus_UMD|evm.model.AC_000170.1.491 Q9BYJ9 YTHD1_HUMAN 88.398 0.88707 1.09302 YTHDF1 - YTH domain-containing family protein 1 - Homo sapiens (Human) - YTHDF1 gene Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability (PubMed:24284625, PubMed:32492408, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:24284625, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31388144, PubMed:31292544, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). Taurus_UMD|evm.model.AC_000170.1.492 Q8NDY6 BHE23_HUMAN 87.556 0.991031 0.991111 Taurus_UMD|evm.model.AC_000170.1.493 Q9BYT1 S17A9_HUMAN 88.761 0.995423 1.00229 SLC17A9 - Solute carrier family 17 member 9 - Homo sapiens (Human) - SLC17A9 gene Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. Taurus_UMD|evm.model.AC_000170.1.494 Q32L52 GID8_BOVIN 100.000 0.991266 1.00439 GID8 - Glucose-induced degradation protein 8 homolog - Bos taurus (Bovine) - GID8 gene Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation. Taurus_UMD|evm.model.AC_000170.1.496 Q9BTC0 DIDO1_HUMAN 69.462 0.93507 1.04509 DIDO1 - Death-inducer obliterator 1 - Homo sapiens (Human) - DIDO1 gene Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. Taurus_UMD|evm.model.AC_000170.1.497 Q9UL49 TCFL5_HUMAN 92.364 0.992754 0.552 TCFL5 - Transcription factor-like 5 protein - Homo sapiens (Human) - TCFL5 gene Putative transcription factor. Isoform 3 may play a role in early spermatogenesis. Taurus_UMD|evm.model.AC_000170.1.498 Q14050 CO9A3_HUMAN 88.235 0.703827 0.878655 COL9A3 - Collagen alpha-3(IX) chain precursor - Homo sapiens (Human) - COL9A3 gene Structural component of hyaline cartilage and vitreous of the eye. Taurus_UMD|evm.model.AC_000170.1.499 Q9NZT2 OGFR_HUMAN 63.602 0.949627 0.791728 OGFR - Opioid growth factor receptor - Homo sapiens (Human) - OGFR gene Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. Taurus_UMD|evm.model.AC_000170.1.500 Q9NV56 MRGBP_HUMAN 92.568 0.986111 0.705882 MRGBP - MRG/MORF4L-binding protein - Homo sapiens (Human) - MRGBP gene Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Taurus_UMD|evm.model.AC_000170.1.501 Q9NV56 MRGBP_HUMAN 86.486 0.297521 0.593137 MRGBP - MRG/MORF4L-binding protein - Homo sapiens (Human) - MRGBP gene Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Taurus_UMD|evm.model.AC_000170.1.502 P30989 NTR1_HUMAN 87.081 0.995227 1.00239 NTSR1 - Neurotensin receptor type 1 - Homo sapiens (Human) - NTSR1 gene G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197). Taurus_UMD|evm.model.AC_000170.1.503 Q96BD0 SO4A1_HUMAN 77.348 0.921569 1.05956 SLCO4A1 - Solute carrier organic anion transporter family member 4A1 - Homo sapiens (Human) - SLCO4A1 gene Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate. Taurus_UMD|evm.model.AC_000170.1.505 Q3SZJ5 GATA5_BOVIN 100.000 0.937063 1.06452 GATA5 - Transcription factor GATA-5 - Bos taurus (Bovine) - GATA5 gene Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity). Taurus_UMD|evm.model.AC_000170.1.506 Q8NC74 RB8NL_HUMAN 61.882 0.947785 0.951807 RBBP8NL - RBBP8 N-terminal-like protein - Homo sapiens (Human) - RBBP8NL gene extracellular space Taurus_UMD|evm.model.AC_000170.1.507 Q8K3M5 CABL2_MOUSE 86.534 0.92623 1.02521 Cables2 - CDK5 and ABL1 enzyme substrate 2 - Mus musculus (Mouse) - Cables2 gene Unknown. Probably involved in G1-S cell cycle transition. Taurus_UMD|evm.model.AC_000170.1.508 P63221 RS21_PIG 100.000 0.573427 1.72289 RPS21 - 40S ribosomal protein S21 - Sus scrofa (Pig) - RPS21 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, ribosome binding, structural constituent of ribosome, cytoplasmic translation, endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000170.1.509 O15230 LAMA5_HUMAN 81.798 0.991537 0.99134 LAMA5 - Laminin subunit alpha-5 precursor - Homo sapiens (Human) - LAMA5 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Taurus_UMD|evm.model.AC_000170.1.510 A1L5A6 ADRM1_BOVIN 100.000 0.995098 1.00246 ADRM1 - Proteasomal ubiquitin receptor ADRM1 - Bos taurus (Bovine) - ADRM1 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex. Taurus_UMD|evm.model.AC_000170.1.511 Q9H1P3 OSBL2_HUMAN 90.000 0.995842 1.00208 OSBPL2 - Oxysterol-binding protein-related protein 2 - Homo sapiens (Human) - OSBPL2 gene Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane (PubMed:30581148). Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate (PubMed:30581148). Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (PubMed:11279184). Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro) (PubMed:17428193, PubMed:19224871, PubMed:30581148). Taurus_UMD|evm.model.AC_000170.1.512 Q3ZBG0 PSA7_BOVIN 100.000 0.991968 1.00403 PSMA7 - Proteasome subunit alpha type-7 - Bos taurus (Bovine) - PSMA7 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. Taurus_UMD|evm.model.AC_000170.1.513 Q9BX40 LS14B_HUMAN 81.096 0.933333 1.01299 LSM14B - Protein LSM14 homolog B - Homo sapiens (Human) - LSM14B gene Required for oocyte meiotic maturation. May be involved in the storage of translationally inactive mRNAs and protect them from degradation (By similarity). Plays a role in control of mRNA translation (By similarity). Taurus_UMD|evm.model.AC_000170.1.514 Q9QYN8 HRH3_RAT 92.877 0.975871 0.838202 Hrh3 - Histamine H3 receptor - Rattus norvegicus (Rat) - Hrh3 gene The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Taurus_UMD|evm.model.AC_000170.1.515 Q5RDW1 MTG2_PONAB 78.079 0.995086 1.00246 MTG2 - Mitochondrial ribosome-associated GTPase 2 - Pongo abelii (Sumatran orangutan) - MTG2 gene Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process (By similarity). Taurus_UMD|evm.model.AC_000170.1.516 Q08E31 CREST_BOVIN 100.000 0.953883 1.02488 SS18L1 - Calcium-responsive transactivator - Bos taurus (Bovine) - SS18L1 gene Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). Taurus_UMD|evm.model.AC_000170.1.517 O00268 TAF4_HUMAN 94.965 0.997199 0.658065 TAF4 - Transcription initiation factor TFIID subunit 4 - Homo sapiens (Human) - TAF4 gene Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone. Taurus_UMD|evm.model.AC_000170.1.518 P55283 CADH4_HUMAN 93.859 0.961969 0.975983 CDH4 - Cadherin-4 precursor - Homo sapiens (Human) - CDH4 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. Taurus_UMD|evm.model.AC_000170.1.522 P18621 RL17_HUMAN 89.011 0.978261 0.5 RPL17 - 60S ribosomal protein L17 - Homo sapiens (Human) - RPL17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000170.1.524 Q8IXH8 CAD26_HUMAN 64.945 0.975217 0.969952 CDH26 - Cadherin-like protein 26 precursor - Homo sapiens (Human) - CDH26 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation (PubMed:28051089). Taurus_UMD|evm.model.AC_000170.1.525 Q9NTX9 F217B_HUMAN 68.312 0.992147 0.997389 FAM217B - Protein FAM217B - Homo sapiens (Human) - FAM217B gene cytosol, nucleoplasm Taurus_UMD|evm.model.AC_000170.1.526 O95685 PPR3D_HUMAN 88.294 0.993333 1.00334 PPP1R3D - Protein phosphatase 1 regulatory subunit 3D - Homo sapiens (Human) - PPP1R3D gene Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Taurus_UMD|evm.model.AC_000170.1.527 Q9BX26 SYCP2_HUMAN 78.476 0.541339 0.996078 SYCP2 - Synaptonemal complex protein 2 - Homo sapiens (Human) - SYCP2 gene Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements. Taurus_UMD|evm.model.AC_000170.1.528 Q96KR7 PHAR3_HUMAN 79.592 0.646925 0.785331 PHACTR3 - Phosphatase and actin regulator 3 - Homo sapiens (Human) - PHACTR3 gene nucleoplasm, actin binding, actin cytoskeleton organization Taurus_UMD|evm.model.AC_000170.1.529 Q96KR7 PHAR3_HUMAN 70.312 0.717647 0.152057 PHACTR3 - Phosphatase and actin regulator 3 - Homo sapiens (Human) - PHACTR3 gene nucleoplasm, actin binding, actin cytoskeleton organization Taurus_UMD|evm.model.AC_000170.1.530 A5A752 EDN3_PIG 71.053 0.726829 1.0049 EDN3 - Endothelin-3 precursor - Sus scrofa (Pig) - EDN3 gene Endothelins are endothelium-derived vasoconstrictor peptides. Taurus_UMD|evm.model.AC_000170.1.534 Q58DB0 PLD3B_BOVIN 88.660 0.989247 0.958763 PRELID3B - PRELI domain containing protein 3B - Bos taurus (Bovine) - PRELID3B gene mitochondrial intermembrane space, phosphatidic acid transfer activity, phospholipid transport Taurus_UMD|evm.model.AC_000170.1.535 A2AQ07 TBB1_MOUSE 90.233 0.95122 1 Tubb1 - Tubulin beta-1 chain - Mus musculus (Mouse) - Tubb1 gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Taurus_UMD|evm.model.AC_000170.1.536 P05689 CATZ_BOVIN 99.671 0.993443 1.00329 CTSZ - Cathepsin Z precursor - Bos taurus (Bovine) - CTSZ gene Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Capable of producing kinin potentiating peptides (By similarity). Taurus_UMD|evm.model.AC_000170.1.537 A5GFY4 NELFD_PIG 98.644 0.99661 1 NELFCD - Negative elongation factor D - Sus scrofa (Pig) - NELFCD gene Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). Taurus_UMD|evm.model.AC_000170.1.538 P04896 GNAS2_BOVIN 95.968 0.369154 2.55076 GNAS - Guanine nucleotide-binding protein G(s) subunit alpha isoforms short - Bos taurus (Bovine) - GNAS gene Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:2022671, PubMed:9395396, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:19243146). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2 (By similarity). Taurus_UMD|evm.model.AC_000170.1.540 O18979 GNAS3_BOVIN 100.000 0.991736 1.00415 GNAS - Neuroendocrine secretory protein 55 precursor - Bos taurus (Bovine) - GNAS gene negative regulation of multicellular organism growth Taurus_UMD|evm.model.AC_000170.1.542 Q9H5I5 PIEZ2_HUMAN 30.568 0.648968 0.123183 PIEZO2 - Piezo-type mechanosensitive ion channel component 2 - Homo sapiens (Human) - PIEZO2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. Taurus_UMD|evm.model.AC_000170.1.543 Q8CD54 PIEZ2_MOUSE 50.694 0.187335 0.268604 Piezo2 - Piezo-type mechanosensitive ion channel component 2 - Mus musculus (Mouse) - Piezo2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:20813920, PubMed:24717433). Required for Merkel-cell mechanotransduction (PubMed:24717433). Plays a major role in light-touch mechanosensation (PubMed:25471886). Taurus_UMD|evm.model.AC_000170.1.544 Q8CD54 PIEZ2_MOUSE 55.556 0.157609 0.260808 Piezo2 - Piezo-type mechanosensitive ion channel component 2 - Mus musculus (Mouse) - Piezo2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:20813920, PubMed:24717433). Required for Merkel-cell mechanotransduction (PubMed:24717433). Plays a major role in light-touch mechanosensation (PubMed:25471886). Taurus_UMD|evm.model.AC_000170.1.545 Q8CD54 PIEZ2_MOUSE 62.025 0.614173 0.0450035 Piezo2 - Piezo-type mechanosensitive ion channel component 2 - Mus musculus (Mouse) - Piezo2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:20813920, PubMed:24717433). Required for Merkel-cell mechanotransduction (PubMed:24717433). Plays a major role in light-touch mechanosensation (PubMed:25471886). Taurus_UMD|evm.model.AC_000170.1.546 Q5R7G6 PEPL1_PONAB 94.304 0.973251 0.929254 NPEPL1 - Probable aminopeptidase NPEPL1 - Pongo abelii (Sumatran orangutan) - NPEPL1 gene Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Taurus_UMD|evm.model.AC_000170.1.547 Q8BVI5 STX16_MOUSE 95.050 0.923547 1.00307 Stx16 - Syntaxin-16 - Mus musculus (Mouse) - Stx16 gene SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Taurus_UMD|evm.model.AC_000170.1.548 Q8NCL9 APCDL_HUMAN 79.749 0.993724 0.954092 APCDD1L - Protein APCDD1-like precursor - Homo sapiens (Human) - APCDD1L gene Taurus_UMD|evm.model.AC_000170.1.549 A2VDZ9 VAPB_BOVIN 100.000 0.991803 1.00412 VAPB - Vesicle-associated membrane protein-associated protein B - Bos taurus (Bovine) - VAPB gene Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. Taurus_UMD|evm.model.AC_000170.1.550 Q9UL26 RB22A_HUMAN 98.454 0.989744 1.00515 RAB22A - Ras-related protein Rab-22A - Homo sapiens (Human) - RAB22A gene Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905). Taurus_UMD|evm.model.AC_000170.1.551 Q8TF05 PP4R1_HUMAN 78.788 0.102521 0.626316 PPP4R1 - Serine/threonine-protein phosphatase 4 regulatory subunit 1 - Homo sapiens (Human) - PPP4R1 gene Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Taurus_UMD|evm.model.AC_000170.1.552 Q9BZ19 ANR60_HUMAN 67.368 0.850299 0.968116 ANKRD60 - Ankyrin repeat domain-containing protein 60 - Homo sapiens (Human) - ANKRD60 gene Taurus_UMD|evm.model.AC_000170.1.553 Q9H1P6 CT085_HUMAN 86.861 0.985507 1.0073 C20orf85 - Uncharacterized protein C20orf85 - Homo sapiens (Human) - C20orf85 gene Taurus_UMD|evm.model.AC_000170.1.554 Q969W9 PMEPA_HUMAN 91.034 0.993103 1.01045 PMEPA1 - Protein TMEPAI - Homo sapiens (Human) - PMEPA1 gene Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). Taurus_UMD|evm.model.AC_000170.1.555 Q9H171 ZBP1_HUMAN 54.455 0.965432 0.944056 ZBP1 - Z-DNA-binding protein 1 - Homo sapiens (Human) - ZBP1 gene Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death (PubMed:32200799). Once activated upon Z-RNA-binding, ZBP1 interacts with RIPK3, inducing the complementary pathways of apoptosis, necroptosis and pyroptosis (By similarity). Acts as a key activator of necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members: ZBP1-dependent necroptosis involves RIPK3 stimulation, which phosphorylates and activates MLKL, triggering execution of programmed necrosis (By similarity). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: ZBP1 recognizes and binds Z-RNA structures that are produced in infected nuclei by orthomyxoviruses, such as the influenza A virus (IAV), leading to ZBP1 activation, RIPK3 stimulation and subsequent MLKL phosphorylation, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (PubMed:32200799). ZBP1-dependent cell death in response to IAV infection promotes interleukin-1 alpha (IL1A) induction in an NLRP3-inflammasome-independent manner: IL1A expression is required for the optimal interleukin-1 beta (IL1B) production, and together, these cytokines promote infiltration of inflammatory neutrophils to the lung, leading to the formation of neutrophil extracellular traps (By similarity). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with RIPK3, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). Taurus_UMD|evm.model.AC_000170.1.556 Q8HYZ4 PCKGC_BOVIN 98.875 0.926866 1.07717 PCK1 - Phosphoenolpyruvate carboxykinase, cytosolic [GTP] - Bos taurus (Bovine) - PCK1 gene Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis. Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate (By similarity). Acts as a regulator of formation and maintenance of memory CD8(+) T-cells: up-regulated in these cells, where it generates phosphoenolpyruvate, via gluconeogenesis. The resultant phosphoenolpyruvate flows to glycogen and pentose phosphate pathway, which is essential for memory CD8(+) T-cells homeostasis (By similarity). In addition to the phosphoenolpyruvate carboxykinase activity, also acts as a protein kinase when phosphorylated at Ser-90: phosphorylation at Ser-90 by AKT1 reduces the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as donor. The protein kinase activity regulates lipogenesis: upon phosphorylation at Ser-90, translocates to the endoplasmic reticulum and catalyzes phosphorylation of INSIG proteins (INSIG1 and INSIG2), thereby disrupting the interaction between INSIG proteins and SCAP and promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes (By similarity). Taurus_UMD|evm.model.AC_000170.1.557 Q08705 CTCF_CHICK 67.027 0.548193 0.912088 CTCF - Transcriptional repressor CTCF - Gallus gallus (Chicken) - CTCF gene Acts as both a transcriptional activator and repressor of the MYC gene. Taurus_UMD|evm.model.AC_000170.1.558 Q9H0Z9 RBM38_HUMAN 96.234 0.991667 1.00418 RBM38 - RNA-binding protein 38 - Homo sapiens (Human) - RBM38 gene RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. Taurus_UMD|evm.model.AC_000170.1.559 Q5E9A4 RAE1L_BOVIN 100.000 0.428238 2.3288 RAE1 - mRNA export factor - Bos taurus (Bovine) - RAE1 gene Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Taurus_UMD|evm.model.AC_000170.1.560 P18075 BMP7_HUMAN 97.912 0.99537 1.00232 BMP7 - Bone morphogenetic protein 7 precursor - Homo sapiens (Human) - BMP7 gene Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:31208997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:9748228, PubMed:12667445). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor (PubMed:31208997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061). Taurus_UMD|evm.model.AC_000170.1.562 Q92754 AP2C_HUMAN 94.222 0.995565 1.00222 TFAP2C - Transcription factor AP-2 gamma - Homo sapiens (Human) - TFAP2C gene Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Taurus_UMD|evm.model.AC_000170.1.563 Q3SYR7 RL9_BOVIN 98.438 0.989637 1.00521 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000170.1.564 Q5JX71 F209A_HUMAN 60.234 0.690377 1.39766 FAM209A - Protein FAM209A precursor - Homo sapiens (Human) - FAM209A gene extracellular exosome, nucleus Taurus_UMD|evm.model.AC_000170.1.565 Q0VCR1 RTF2_BOVIN 99.666 0.993333 1.00334 RTF2 - Replication termination factor 2 - Bos taurus (Bovine) - RTF2 gene Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Taurus_UMD|evm.model.AC_000170.1.566 A5GFW5 CASS4_PIG 76.572 0.997537 1.03571 CASS4 - Cas scaffolding protein family member 4 - Sus scrofa (Pig) - CASS4 gene Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading (By similarity). Taurus_UMD|evm.model.AC_000170.1.567 Q5BJQ6 CSTF1_RAT 99.536 0.99537 1.00232 Cstf1 - Cleavage stimulation factor subunit 1 - Rattus norvegicus (Rat) - Cstf1 gene One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (By similarity). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (By similarity). Taurus_UMD|evm.model.AC_000170.1.568 Q2TA06 AURKA_BOVIN 100.000 0.995037 1.00249 AURKA - Aurora kinase A - Bos taurus (Bovine) - AURKA gene Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (By similarity). Taurus_UMD|evm.model.AC_000170.1.569 Q96KR6 F210B_HUMAN 83.333 0.989637 1.00521 FAM210B - Protein FAM210B, mitochondrial precursor - Homo sapiens (Human) - FAM210B gene Plays a role in erythroid differentiation (PubMed:26968549). Involved in cell proliferation and tumor cell growth suppression (PubMed:28594398). Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner (PubMed:28594398). Taurus_UMD|evm.model.AC_000170.1.570 P41968 MC3R_HUMAN 91.950 0.993827 1.0031 MC3R - Melanocortin receptor 3 - Homo sapiens (Human) - MC3R gene Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. Taurus_UMD|evm.model.AC_000170.1.571 Q5JXA9 SIRB2_HUMAN 74.825 0.450949 1.84795 SIRPB2 - Signal-regulatory protein beta-2 precursor - Homo sapiens (Human) - SIRPB2 gene plasma membrane Taurus_UMD|evm.model.AC_000170.1.572 Q3SZC4 NSF1C_BOVIN 100.000 0.994609 1.0027 NSFL1C - NSFL1 cofactor p47 - Bos taurus (Bovine) - NSFL1C gene Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. Taurus_UMD|evm.model.AC_000170.1.573 P18203 FKB1A_BOVIN 85.185 0.978495 0.861111 FKBP1A - Peptidyl-prolyl cis-trans isomerase FKBP1A - Bos taurus (Bovine) - FKBP1A gene Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Taurus_UMD|evm.model.AC_000170.1.574 Q9H190 SDCB2_HUMAN 84.151 0.988764 0.914384 SDCBP2 - Syntenin-2 - Homo sapiens (Human) - SDCBP2 gene Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997). Taurus_UMD|evm.model.AC_000170.1.575 O15079 SNPH_HUMAN 90.946 0.915129 1.09717 SNPH - Syntaphilin - Homo sapiens (Human) - SNPH gene Inhibits SNARE complex formation by absorbing free syntaxin-1. Taurus_UMD|evm.model.AC_000170.1.576 D2HSB3 RD21L_AILME 84.601 0.90312 1.09928 RAD21L1 - Double-strand-break repair protein rad21-like protein 1 - Ailuropoda melanoleuca (Giant panda) - RAD21L1 gene Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity). Taurus_UMD|evm.model.AC_000170.1.577 Q9NUR3 TM74B_HUMAN 89.700 0.991453 0.914062 TMEM74B - Transmembrane protein 74B - Homo sapiens (Human) - TMEM74B gene Taurus_UMD|evm.model.AC_000170.1.578 Q3SX30 PSMF1_BOVIN 100.000 0.99262 1.0037 PSMF1 - Proteasome inhibitor PI31 subunit - Bos taurus (Bovine) - PSMF1 gene Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). Taurus_UMD|evm.model.AC_000170.1.580 Q2I0M5 RSPO4_HUMAN 82.456 0.97235 0.92735 RSPO4 - R-spondin-4 precursor - Homo sapiens (Human) - RSPO4 gene Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21727895, PubMed:21909076). Taurus_UMD|evm.model.AC_000170.1.581 Q24K15 ANGP4_BOVIN 89.357 0.995526 0.89759 ANGPT4 - Angiopoietin-4 precursor - Bos taurus (Bovine) - ANGPT4 gene Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis (By similarity). Taurus_UMD|evm.model.AC_000170.1.582 Q58DG5 F110A_BOVIN 100.000 0.993243 1.00339 FAM110A - Protein FAM110A - Bos taurus (Bovine) - FAM110A gene Taurus_UMD|evm.model.AC_000170.1.583 Q5E9R1 S52A3_BOVIN 100.000 0.995726 1.00214 SLC52A3 - Solute carrier family 52, riboflavin transporter, member 3 - Bos taurus (Bovine) - SLC52A3 gene Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Taurus_UMD|evm.model.AC_000170.1.584 Q9NQ03 SCRT2_HUMAN 97.802 0.545455 0.537459 SCRT2 - Transcriptional repressor scratch 2 - Homo sapiens (Human) - SCRT2 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000170.1.585 Q9BYN0 SRXN1_HUMAN 94.891 0.978417 1.0146 SRXN1 - Sulfiredoxin-1 - Homo sapiens (Human) - SRXN1 gene Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. Taurus_UMD|evm.model.AC_000170.1.586 Q60756 TCF15_MOUSE 94.416 0.989899 1.01538 Tcf15 - Transcription factor 15 - Mus musculus (Mouse) - Tcf15 gene Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency (PubMed:7597044, PubMed:8955271, PubMed:23395635, PubMed:32669716, PubMed:24038871). Essential for the mesenchymal to epithelial transition associated with somite formation (PubMed:7597044, PubMed:8955271, PubMed:24038871). Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles (PubMed:8955271). Required for proper localization of somite epithelium markers during the mesenchymal to epithelial transition (PubMed:24038871). Also plays a key role in regulation of stem cell pluripotency (PubMed:23395635, PubMed:32669716). Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation (PubMed:23395635). Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long-term self-renewal (PubMed:32669716). Together with MEOX2, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (PubMed:25561514). Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, such as TCF3/E12, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes (PubMed:15226298, PubMed:23395635). Taurus_UMD|evm.model.AC_000170.1.587 P68400 CSK21_HUMAN 100.000 0.919308 0.887468 CSNK2A1 - Casein kinase II subunit alpha - Homo sapiens (Human) - CSNK2A1 gene Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621, PubMed:24962073). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:12631575, PubMed:19387552, PubMed:19387551). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387552, PubMed:19387551). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:11704824, PubMed:19188443). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis (PubMed:11239457). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:16193064). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:16193064). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551, PubMed:23123191). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90 (PubMed:30699359). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551). Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (PubMed:20625391, PubMed:22406621). Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073). Taurus_UMD|evm.model.AC_000170.1.588 Q2T9Q1 TBC20_BOVIN 100.000 0.99505 1.00248 TBC1D20 - TBC1 domain family member 20 - Bos taurus (Bovine) - TBC1D20 gene GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. Taurus_UMD|evm.model.AC_000170.1.589 Q9BYM8 HOIL1_HUMAN 94.706 0.996086 1.00196 RBCK1 - RanBP-type and C3HC4-type zinc finger-containing protein 1 - Homo sapiens (Human) - RBCK1 gene E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types. Taurus_UMD|evm.model.AC_000170.1.590 Q0VCE3 TRIB3_BOVIN 100.000 0.967391 1.03081 TRIB3 - Tribbles homolog 3 - Bos taurus (Bovine) - TRIB3 gene Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (By similarity). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (By similarity). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity. Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases (By similarity). Can inhibit APOBEC3A editing of nuclear DNA (By similarity). Taurus_UMD|evm.model.AC_000170.1.591 Q9GZP1 NRSN2_HUMAN 86.634 0.985294 1 NRSN2 - Neurensin-2 - Homo sapiens (Human) - NRSN2 gene May play a role in maintenance and/or transport of vesicles. Taurus_UMD|evm.model.AC_000170.1.592 O15370 SOX12_HUMAN 95.896 0.992537 0.850794 SOX12 - Transcription factor SOX-12 - Homo sapiens (Human) - SOX12 gene Transcription factor that binds to DNA at the consensus sequence 5'-ACCAAAG-3' (By similarity). Acts as a transcriptional activator (By similarity). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Involved in the differentiation of naive CD4-positive T-cells into peripherally induced regulatory T (pT reg) cells under inflammatory conditions (By similarity). Binds to the promoter region of the FOXP3 gene and promotes its transcription, and might thereby contribute to pT reg cell differentiation in the spleen and lymph nodes during inflammation (By similarity). Plays a redundant role with SOX4 and SOX11 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity). Taurus_UMD|evm.model.AC_000170.1.593 Q9NUD5 ZCHC3_HUMAN 78.286 0.919355 0.461538 ZCCHC3 - Zinc finger CCHC domain-containing protein 3 - Homo sapiens (Human) - ZCCHC3 gene Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424). Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58/RIG-I and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of DDX58/RIG-I and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58/RIG-I and IFIH1/MDA5 (PubMed:30193849). Taurus_UMD|evm.model.AC_000170.1.594 Q9NUD7 CT096_HUMAN 58.953 0.994475 0.997245 C20orf96 - Uncharacterized protein C20orf96 - Homo sapiens (Human) - C20orf96 gene Taurus_UMD|evm.model.AC_000170.1.595 A4H265 DB132_MACFA 46.154 0.712644 0.915789 DEFB132 - Beta-defensin 132 precursor - Macaca fascicularis (Crab-eating macaque) - DEFB132 gene Has antibacterial activity. Taurus_UMD|evm.model.AC_000170.1.596 A4H257 DB129_GORGO 63.265 0.776596 1.02732 DEFB129 - Beta-defensin 129 precursor - Gorilla gorilla gorilla (Western lowland gorilla) - DEFB129 gene Has antibacterial activity. Taurus_UMD|evm.model.AC_000170.1.597 Q8K3U4 DFB36_MOUSE 66.667 0.53 1.49254 Defb36 - Beta-defensin 36 precursor - Mus musculus (Mouse) - Defb36 gene Has antibacterial activity. Taurus_UMD|evm.model.AC_000170.1.598 Q30KK4 DB124_PANTR 82.258 0.525862 1.6338 DEFB124 - Beta-defensin 124 precursor - Pan troglodytes (Chimpanzee) - DEFB124 gene Has antibacterial activity. Taurus_UMD|evm.model.AC_000170.1.599 O75628 REM1_HUMAN 92.282 0.993311 1.00336 REM1 - GTP-binding protein REM 1 - Homo sapiens (Human) - REM1 gene Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling. Taurus_UMD|evm.model.AC_000170.1.600 Q8TCT9 HM13_HUMAN 97.082 0.994709 1.00265 HM13 - Minor histocompatibility antigen H13 - Homo sapiens (Human) - HM13 gene Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity). Taurus_UMD|evm.model.AC_000170.1.601 P41134 ID1_HUMAN 91.489 0.903226 1 ID1 - DNA-binding protein inhibitor ID-1 - Homo sapiens (Human) - ID1 gene Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Taurus_UMD|evm.model.AC_000170.1.603 Q96KJ9 COX42_HUMAN 79.532 0.988372 1.00585 COX4I2 - Cytochrome c oxidase subunit 4 isoform 2, mitochondrial precursor - Homo sapiens (Human) - COX4I2 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000170.1.604 Q07817 B2CL1_HUMAN 97.826 0.867424 1.13305 BCL2L1 - Bcl-2-like protein 1 - Homo sapiens (Human) - BCL2L1 gene Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Taurus_UMD|evm.model.AC_000170.1.605 A6H6Z7 TPX2_BOVIN 93.842 0.997326 1.0625 TPX2 - Targeting protein for Xklp2 - Bos taurus (Bovine) - TPX2 gene Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation. Taurus_UMD|evm.model.AC_000170.1.606 A4IFM7 MYLK2_BOVIN 100.000 0.996795 1.00161 MYLK2 - Myosin light chain kinase 2, skeletal/cardiac muscle - Bos taurus (Bovine) - MYLK2 gene Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain (By similarity). Taurus_UMD|evm.model.AC_000170.1.607 O43638 FOXS1_HUMAN 85.152 0.993958 1.00303 FOXS1 - Forkhead box protein S1 - Homo sapiens (Human) - FOXS1 gene Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity). Taurus_UMD|evm.model.AC_000170.1.608 Q64287 IRF4_MOUSE 41.330 0.897436 0.953333 Irf4 - Interferon regulatory factor 4 - Mus musculus (Mouse) - Irf4 gene Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes. Taurus_UMD|evm.model.AC_000170.1.609 Q9H1R2 DUS15_HUMAN 93.662 0.597458 0.8 DUSP15 - Dual specificity protein phosphatase 15 - Homo sapiens (Human) - DUSP15 gene May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (PubMed:22792334). Taurus_UMD|evm.model.AC_000170.1.610 Q3SZH6 TTLL9_BOVIN 100.000 0.831301 1.06725 TTLL9 - Probable tubulin polyglutamylase TTLL9 - Bos taurus (Bovine) - TTLL9 gene Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Acts when complexed with other proteins. By mediating tubulin polyglutamylation, plays a role in the establishment of microtubule heterogeneity in sperm flagella. Taurus_UMD|evm.model.AC_000170.1.611 Q148L7 PDRG1_BOVIN 100.000 0.985075 1.00752 PDRG1 - p53 and DNA damage-regulated protein 1 - Bos taurus (Bovine) - PDRG1 gene May play a role in chaperone-mediated protein folding. Taurus_UMD|evm.model.AC_000170.1.612 Q5GH72 XKR7_HUMAN 92.069 0.996558 1.00345 XKR7 - XK-related protein 7 - Homo sapiens (Human) - XKR7 gene membrane, plasma membrane, apoptotic process involved in development, engulfment of apoptotic cell, phosphatidylserine exposure on apoptotic cell surface Taurus_UMD|evm.model.AC_000170.1.613 Q9NUG4 CCM2L_HUMAN 93.531 0.996485 0.996497 CCM2L - Cerebral cavernous malformations 2 protein-like - Homo sapiens (Human) - CCM2L gene Taurus_UMD|evm.model.AC_000170.1.615 Q95M30 HCK_MACFA 91.468 0.967245 1.02976 HCK - Tyrosine-protein kinase HCK - Macaca fascicularis (Crab-eating macaque) - HCK gene Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS (By similarity). Taurus_UMD|evm.model.AC_000170.1.616 A5D7E2 TM9S4_BOVIN 100.000 0.99689 1.00156 TM9SF4 - Transmembrane 9 superfamily member 4 precursor - Bos taurus (Bovine) - TM9SF4 gene Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Taurus_UMD|evm.model.AC_000170.1.617 Q8VD63 TSYL4_MOUSE 61.905 0.350427 0.288177 Tspyl4 - Testis-specific Y-encoded-like protein 4 - Mus musculus (Mouse) - Tspyl4 gene chromatin, nucleus, chromatin binding, histone binding Taurus_UMD|evm.model.AC_000170.1.618 Q9UPG8 PLAL2_HUMAN 97.782 0.995976 1.00202 PLAGL2 - Zinc finger protein PLAGL2 - Homo sapiens (Human) - PLAGL2 gene Shows weak transcriptional activatory activity. Taurus_UMD|evm.model.AC_000170.1.619 Q6EV69 OFUT1_PANTR 92.072 0.994898 1.01031 POFUT1 - GDP-fucose protein O-fucosyltransferase 1 precursor - Pan troglodytes (Chimpanzee) - POFUT1 gene Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs). Taurus_UMD|evm.model.AC_000170.1.620 O15066 KIF3B_HUMAN 97.456 0.997312 0.995984 KIF3B - Kinesin-like protein KIF3B - Homo sapiens (Human) - KIF3B gene Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (By similarity). Plays a role in cilia formation (PubMed:32386558). Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors (PubMed:32386558). Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites (By similarity). Taurus_UMD|evm.model.AC_000170.1.621 Q8IXJ9 ASXL1_HUMAN 79.249 0.998673 0.977936 ASXL1 - Polycomb group protein ASXL1 - Homo sapiens (Human) - ASXL1 gene Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (PubMed:30982744). Taurus_UMD|evm.model.AC_000170.1.622 Q96MY1 NOL4L_HUMAN 95.642 0.735593 1.35321 NOL4L - Nucleolar protein 4-like - Homo sapiens (Human) - NOL4L gene cytosol, nucleoplasm Taurus_UMD|evm.model.AC_000170.1.623 Q3MHX1 COMD7_BOVIN 100.000 0.99005 1.005 COMMD7 - COMM domain-containing protein 7 - Bos taurus (Bovine) - COMMD7 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Associates with the NF-kappa-B complex and suppresses its transcriptional activity. Taurus_UMD|evm.model.AC_000170.1.624 Q9UBC3 DNM3B_HUMAN 88.799 0.955682 1.03165 DNMT3B - DNA (cytosine-5)-methyltransferase 3B - Homo sapiens (Human) - DNMT3B gene Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398). Taurus_UMD|evm.model.AC_000170.1.625 Q3ZBD9 MARE1_BOVIN 100.000 0.939623 0.988806 MAPRE1 - Microtubule-associated protein RP/EB family member 1 - Bos taurus (Bovine) - MAPRE1 gene Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (By similarity). May play a role in cell migration (By similarity). Taurus_UMD|evm.model.AC_000170.1.626 A8MWE9 EFCB8_HUMAN 60.000 0.114376 8.74306 EFCAB8 - EF-hand calcium-binding domain-containing protein 8 - Homo sapiens (Human) - EFCAB8 gene Taurus_UMD|evm.model.AC_000170.1.627 Q8TC36 SUN5_HUMAN 80.481 0.994638 0.984169 SUN5 - SUN domain-containing protein 5 - Homo sapiens (Human) - SUN5 gene Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope. Taurus_UMD|evm.model.AC_000170.1.628 Q8N4F0 BPIB2_HUMAN 73.529 0.958696 1.00437 BPIFB2 - BPI fold-containing family B member 2 precursor - Homo sapiens (Human) - BPIFB2 gene endoplasmic reticulum lumen, extracellular exosome, extracellular region, antimicrobial humoral response, cellular protein metabolic process, post-translational protein modification Taurus_UMD|evm.model.AC_000170.1.629 Q8BU51 BPIB6_MOUSE 71.955 0.88191 0.886414 Bpifb6 - BPI fold-containing family B member 6 precursor - Mus musculus (Mouse) - Bpifb6 gene Taurus_UMD|evm.model.AC_000170.1.630 Q05704 BPIB4_RAT 85.304 0.56308 1.74716 Bpifb4 - BPI fold-containing family B member 4 precursor - Rattus norvegicus (Rat) - Bpifb4 gene May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity). Taurus_UMD|evm.model.AC_000170.1.631 P79125 SPL2B_BOVIN 58.333 0.282937 1.92917 SPLUNC2B - Short palate, lung and nasal epithelium carcinoma-associated protein 2B precursor - Bos taurus (Bovine) - SPLUNC2B gene secretory granule, lipopolysaccharide binding Taurus_UMD|evm.model.AC_000170.1.632 P79124 SPL2A_BOVIN 99.127 0.37013 2.57741 SPLUNC2A - Short palate, lung and nasal epithelium carcinoma-associated protein 2A precursor - Bos taurus (Bovine) - SPLUNC2A gene secretory granule, lipopolysaccharide binding Taurus_UMD|evm.model.AC_000170.1.633 P79124 SPL2A_BOVIN 52.632 0.763514 0.619247 SPLUNC2A - Short palate, lung and nasal epithelium carcinoma-associated protein 2A precursor - Bos taurus (Bovine) - SPLUNC2A gene secretory granule, lipopolysaccharide binding Taurus_UMD|evm.model.AC_000170.1.634 P79125 SPL2B_BOVIN 99.558 0.490196 1.9125 SPLUNC2B - Short palate, lung and nasal epithelium carcinoma-associated protein 2B precursor - Bos taurus (Bovine) - SPLUNC2B gene secretory granule, lipopolysaccharide binding Taurus_UMD|evm.model.AC_000170.1.635 Q9BQP9 BPIA3_HUMAN 67.094 0.974895 0.940945 BPIFA3 - BPI fold-containing family A member 3 precursor - Homo sapiens (Human) - BPIFA3 gene Taurus_UMD|evm.model.AC_000170.1.636 Q8SPU5 BPIA1_BOVIN 100.000 0.992188 1.00392 BPIFA1 - BPI fold-containing family A member 1 precursor - Bos taurus (Bovine) - BPIFA1 gene Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. Taurus_UMD|evm.model.AC_000170.1.638 Q8SPF8 BPIB1_BOVIN 99.789 0.995781 1.00211 BPIFB1 - BPI fold-containing family B member 1 precursor - Bos taurus (Bovine) - BPIFB1 gene May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS (By similarity). Taurus_UMD|evm.model.AC_000170.1.639 Q63751 VOME_RAT 43.772 0.496262 1.81664 Bpifb9 - Vomeromodulin precursor - Rattus norvegicus (Rat) - Bpifb9 gene Taurus_UMD|evm.model.AC_000170.1.640 Q96SZ6 CK5P1_HUMAN 87.396 0.99661 0.981697 CDK5RAP1 - Mitochondrial tRNA methylthiotransferase CDK5RAP1 precursor - Homo sapiens (Human) - CDK5RAP1 gene Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:22422838, PubMed:25738458, PubMed:28981754). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:22422838, PubMed:25738458, PubMed:28981754). Specifically inhibits CDK5 activation by CDK5R1 (PubMed:11882646). Essential for efficient mitochondrial protein synthesis and respiratory chain; shows pathological consequences in mitochondrial disease (PubMed:25738458). Taurus_UMD|evm.model.AC_000170.1.641 Q0P5E6 SNTA1_BOVIN 100.000 0.996047 1.00198 SNTA1 - Alpha-1-syntrophin - Bos taurus (Bovine) - SNTA1 gene Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity). Taurus_UMD|evm.model.AC_000170.1.642 O43439 MTG8R_HUMAN 96.604 0.986577 0.986755 CBFA2T2 - Protein CBFA2T2 - Homo sapiens (Human) - CBFA2T2 gene Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). Taurus_UMD|evm.model.AC_000170.1.643 A2VDW6 NECA3_BOVIN 99.721 0.901515 1.10615 NECAB3 - N-terminal EF-hand calcium-binding protein 3 - Bos taurus (Bovine) - NECAB3 gene Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta (By similarity). May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3 (By similarity). Taurus_UMD|evm.model.AC_000170.1.644 Q01094 E2F1_HUMAN 87.892 0.995526 1.02288 E2F1 - Transcription factor E2F1 - Homo sapiens (Human) - E2F1 gene Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599). Taurus_UMD|evm.model.AC_000170.1.645 A5PJL1 PXMP4_BOVIN 100.000 0.99061 1.00472 PXMP4 - Peroxisomal membrane protein 4 - Bos taurus (Bovine) - PXMP4 gene peroxisomal membrane Taurus_UMD|evm.model.AC_000170.1.646 Q9BYN7 ZN341_HUMAN 93.326 0.997661 1.00117 ZNF341 - Zinc finger protein 341 - Homo sapiens (Human) - ZNF341 gene Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription. Taurus_UMD|evm.model.AC_000170.1.647 Q9H444 CHM4B_HUMAN 97.321 0.991111 1.00446 CHMP4B - Charged multivesicular body protein 4b - Homo sapiens (Human) - CHMP4B gene Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Taurus_UMD|evm.model.AC_000170.1.648 Q64012 RALY_MOUSE 87.500 0.993333 0.961538 Raly - RNA-binding protein Raly - Mus musculus (Mouse) - Raly gene RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver (PubMed:27251289). Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (PubMed:27251289). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (By similarity). Taurus_UMD|evm.model.AC_000170.1.649 Q5E9D0 IF2B_BOVIN 99.700 0.994012 1.003 EIF2S2 - Eukaryotic translation initiation factor 2 subunit 2 - Bos taurus (Bovine) - EIF2S2 gene eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). Taurus_UMD|evm.model.AC_000170.1.650 Q29414 ASIP_BOVIN 100.000 0.985075 1.00752 ASIP - Agouti-signaling protein precursor - Bos taurus (Bovine) - ASIP gene Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). Taurus_UMD|evm.model.AC_000170.1.651 Q3MHL4 SAHH_BOVIN 100.000 0.995381 1.00231 AHCY - Adenosylhomocysteinase - Bos taurus (Bovine) - AHCY gene Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Taurus_UMD|evm.model.AC_000170.1.652 P47832 RL26_CHICK 99.219 0.819355 1.21094 RPL26 - 60S ribosomal protein L26 - Gallus gallus (Chicken) - RPL26 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome, cytoplasmic translation, ribosomal large subunit biogenesis Taurus_UMD|evm.model.AC_000170.1.653 Q8C863 ITCH_MOUSE 95.486 0.997683 0.998843 Itch - E3 ubiquitin-protein ligase Itchy - Mus musculus (Mouse) - Itch gene Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:15358865, PubMed:16446428, PubMed:17592138, PubMed:18628966, PubMed:20392206, PubMed:25632008). It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (By similarity). Involved in the control of inflammatory signaling pathways (By similarity). Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (By similarity). Promotes the association of the complex after TNF stimulation (By similarity). Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains (By similarity). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (By similarity). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (By similarity). Regulates the transcriptional activity of several transcription factors involved in immune response (PubMed:15358865, PubMed:11828324). Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages (By similarity). Mediates JUN ubiquitination and degradation (PubMed:15358865). Mediates JUNB ubiquitination and degradation (PubMed:11828324, PubMed:15358865). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (PubMed:11828324). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (By similarity). Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (By similarity). Following ligand stimulation, regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (By similarity). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (By similarity). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (By similarity). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:18628966). Ubiquitinates SNX9 (By similarity). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (PubMed:25632008). Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP (By similarity). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (By similarity). Taurus_UMD|evm.model.AC_000170.1.654 P62628 DLRB1_RAT 100.000 0.752 1.30208 Dynlrb1 - Dynein light chain roadblock-type 1 - Rattus norvegicus (Rat) - Dynlrb1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Taurus_UMD|evm.model.AC_000170.1.655 Q2HJ23 MLP3A_BOVIN 100.000 0.983607 1.00826 MAP1LC3A - Microtubule-associated proteins 1A/1B light chain 3A precursor - Bos taurus (Bovine) - MAP1LC3A gene Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Taurus_UMD|evm.model.AC_000170.1.656 Q9H490 PIGU_HUMAN 96.322 0.995413 1.0023 PIGU - Phosphatidylinositol glycan anchor biosynthesis class U protein - Homo sapiens (Human) - PIGU gene Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI. Taurus_UMD|evm.model.AC_000170.1.657 Q3MHN0 PSB6_BOVIN 75.229 0.84375 0.535565 PSMB6 - Proteasome subunit beta type-6 precursor - Bos taurus (Bovine) - PSMB6 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolyzing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues. Taurus_UMD|evm.model.AC_000170.1.658 Q8IXH6 T53I2_HUMAN 86.161 0.991111 1.02273 TP53INP2 - Tumor protein p53-inducible nuclear protein 2 - Homo sapiens (Human) - TP53INP2 gene Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. Taurus_UMD|evm.model.AC_000170.1.659 Q14686 NCOA6_HUMAN 95.477 0.480722 0.993214 NCOA6 - Nuclear receptor coactivator 6 - Homo sapiens (Human) - NCOA6 gene Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Taurus_UMD|evm.model.AC_000170.1.661 Q0V8L2 GGT7_BOVIN 100.000 0.996983 1.00151 GGT7 - Glutathione hydrolase 7 precursor - Bos taurus (Bovine) - GGT7 gene Cleaves glutathione conjugates. Taurus_UMD|evm.model.AC_000170.1.662 Q9NR19 ACSA_HUMAN 94.009 0.997151 1.00143 ACSS2 - Acetyl-coenzyme A synthetase, cytoplasmic - Homo sapiens (Human) - ACSS2 gene Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429). Acetate is the preferred substrate (PubMed:10843999, PubMed:28003429). Can also utilize propionate with a much lower affinity (By similarity). Taurus_UMD|evm.model.AC_000170.1.663 Q5EAC2 GSHB_BOVIN 99.789 0.987474 1.01055 GSS - Glutathione synthetase - Bos taurus (Bovine) - GSS gene ATP binding, glutathione binding, magnesium ion binding, protein homodimerization activity Taurus_UMD|evm.model.AC_000170.1.664 A7E2Y1 MYH7B_HUMAN 97.184 0.991366 0.99294 MYH7B - Myosin-7B - Homo sapiens (Human) - MYH7B gene Involved in muscle contraction. Taurus_UMD|evm.model.AC_000170.1.665 Q8TEL6 TP4AP_HUMAN 98.871 0.997494 1.00125 TRPC4AP - Short transient receptor potential channel 4-associated protein - Homo sapiens (Human) - TRPC4AP gene Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1. Taurus_UMD|evm.model.AC_000170.1.666 Q9BV94 EDEM2_HUMAN 96.367 0.996546 1.00173 EDEM2 - ER degradation-enhancing alpha-mannosidase-like protein 2 precursor - Homo sapiens (Human) - EDEM2 gene Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655). May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity). Taurus_UMD|evm.model.AC_000170.1.669 Q28105 EPCR_BOVIN 100.000 0.991736 1.00415 PROCR - Endothelial protein C receptor precursor - Bos taurus (Bovine) - PROCR gene Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. Taurus_UMD|evm.model.AC_000170.1.670 Q9Y5R2 MMP24_HUMAN 98.872 0.996248 0.826357 MMP24 - Matrix metalloproteinase-24 precursor - Homo sapiens (Human) - MMP24 gene Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity). Taurus_UMD|evm.model.AC_000170.1.671 Q9TU47 IF6_BOVIN 100.000 0.99187 1.00408 EIF6 - Eukaryotic translation initiation factor 6 - Bos taurus (Bovine) - EIF6 gene Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (By similarity). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity). Taurus_UMD|evm.model.AC_000170.1.672 Q9BQN1 FA83C_HUMAN 79.620 0.997275 0.982597 FAM83C - Protein FAM83C - Homo sapiens (Human) - FAM83C gene May play a role in MAPK signaling. Taurus_UMD|evm.model.AC_000170.1.673 Q9NVA1 UQCC1_HUMAN 97.727 0.184549 0.779264 UQCC1 - Ubiquinol-cytochrome-c reductase complex assembly factor 1 - Homo sapiens (Human) - UQCC1 gene Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability. Taurus_UMD|evm.model.AC_000170.1.674 P43026 GDF5_HUMAN 95.609 0.996 0.998004 GDF5 - Growth/differentiation factor 5 precursor - Homo sapiens (Human) - GDF5 gene Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Taurus_UMD|evm.model.AC_000170.1.675 Q9BV73 CP250_HUMAN 81.357 0.999179 0.997133 CEP250 - Centrosome-associated protein CEP250 - Homo sapiens (Human) - CEP250 gene May be involved in ciliogenesis (PubMed:28005958). Probably plays an important role in centrosome cohesion during interphase. Taurus_UMD|evm.model.AC_000170.1.676 Q6KB54 SIA10_PANTR 39.773 0.310861 0.806647 ST3GAL6 - Type 2 lactosamine alpha-2,3-sialyltransferase - Pan troglodytes (Chimpanzee) - ST3GAL6 gene Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity). Taurus_UMD|evm.model.AC_000170.1.677 Q96LM9 CT173_HUMAN 39.655 0.504386 1.5302 C20orf173 - Uncharacterized protein C20orf173 - Homo sapiens (Human) - C20orf173 gene Taurus_UMD|evm.model.AC_000170.1.678 Q5EAE0 ERGI3_BOVIN 100.000 0.797059 0.887728 ERGIC3 - Endoplasmic reticulum-Golgi intermediate compartment protein 3 - Bos taurus (Bovine) - ERGIC3 gene Possible role in transport between endoplasmic reticulum and Golgi. Taurus_UMD|evm.model.AC_000170.1.679 A9Z1Z3 FR1L4_HUMAN 79.211 0.894627 1.06856 FER1L4 - Fer-1-like protein 4 - Homo sapiens (Human) - FER1L4 gene plasma membrane organization Taurus_UMD|evm.model.AC_000170.1.680 Q9NPE6 SPAG4_HUMAN 87.707 0.956916 1.00915 SPAG4 - Sperm-associated antigen 4 protein - Homo sapiens (Human) - SPAG4 gene Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail. Taurus_UMD|evm.model.AC_000170.1.681 Q08DB4 CPNE1_BOVIN 100.000 0.987109 1.01117 CPNE1 - Copine-1 - Bos taurus (Bovine) - CPNE1 gene Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL. Taurus_UMD|evm.model.AC_000170.1.682 Q5RDE7 NFS1_PONAB 95.128 0.938865 1.00219 NFS1 - Cysteine desulfurase, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - NFS1 gene Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor (By similarity). Taurus_UMD|evm.model.AC_000170.1.683 P60603 ROMO1_MOUSE 100.000 0.975 1.01266 Romo1 - Reactive oxygen species modulator 1 - Mus musculus (Mouse) - Romo1 gene Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage (By similarity). Taurus_UMD|evm.model.AC_000170.1.684 Q14498 RBM39_HUMAN 100.000 0.996234 1.00189 RBM39 - RNA-binding protein 39 - Homo sapiens (Human) - RBM39 gene RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:31271494, PubMed:28437394, PubMed:28302793, PubMed:24795046). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). Taurus_UMD|evm.model.AC_000170.1.685 Q9BVI0 PHF20_HUMAN 91.527 0.998022 0.999012 PHF20 - PHD finger protein 20 - Homo sapiens (Human) - PHF20 gene Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. Taurus_UMD|evm.model.AC_000170.1.686 Q32PG5 SCND1_BOVIN 100.000 0.988827 1.00562 SCAND1 - SCAN domain-containing protein 1 - Bos taurus (Bovine) - SCAND1 gene May regulate transcriptional activity. Taurus_UMD|evm.model.AC_000170.1.687 Q95JR6 CNBD2_MACFA 73.585 0.833094 1.18803 CNBD2 - Cyclic nucleotide-binding domain-containing protein 2 - Macaca fascicularis (Crab-eating macaque) - CNBD2 gene Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm. Taurus_UMD|evm.model.AC_000170.1.688 Q9H4G0 E41L1_HUMAN 94.779 0.980769 1.00341 EPB41L1 - Band 4.1-like protein 1 - Homo sapiens (Human) - EPB41L1 gene May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. Taurus_UMD|evm.model.AC_000170.1.689 Q08DJ7 AAR2_BOVIN 100.000 0.994805 1.0026 AAR2 - Protein AAR2 homolog - Bos taurus (Bovine) - AAR2 gene Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Taurus_UMD|evm.model.AC_000170.1.691 Q9Y2H0 DLGP4_HUMAN 97.480 0.997986 1.00101 DLGAP4 - Disks large-associated protein 4 - Homo sapiens (Human) - DLGAP4 gene May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Taurus_UMD|evm.model.AC_000170.1.692 P02612 MLRM_CHICK 100.000 0.718487 1.38372 Myosin regulatory light chain 2, smooth muscle major isoform - Gallus gallus (Chicken) Taurus_UMD|evm.model.AC_000170.1.693 Q9GZN2 TGIF2_HUMAN 92.827 0.991597 1.00422 TGIF2 - Homeobox protein TGIF2 - Homo sapiens (Human) - TGIF2 gene Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. Taurus_UMD|evm.model.AC_000170.1.694 Q9CQT9 RCAF1_MOUSE 95.349 0.984615 1.00775 Rab5if - Respirasome Complex Assembly Factor 1 - Mus musculus (Mouse) - Rab5if gene Acts as an assembly factor for mitochondrial respiratory complexes. Taurus_UMD|evm.model.AC_000170.1.695 Q9H6Q3 SLAP2_HUMAN 83.969 0.938628 1.0613 SLA2 - Src-like-adapter 2 - Homo sapiens (Human) - SLA2 gene Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Taurus_UMD|evm.model.AC_000170.1.696 Q0VCA5 SAMH1_BOVIN 100.000 0.545151 1.52292 SAMHD1 - Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 - Bos taurus (Bovine) - SAMHD1 gene Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (By similarity). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity (By similarity). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools. Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication. Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation. Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (By similarity). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity). Taurus_UMD|evm.model.AC_000170.1.697 O43598 DNPH1_HUMAN 82.443 0.844156 0.885057 DNPH1 - 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 - Homo sapiens (Human) - DNPH1 gene Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. Taurus_UMD|evm.model.AC_000170.1.698 P46926 GNPI1_HUMAN 60.976 0.590062 0.557093 GNPDA1 - Glucosamine-6-phosphate isomerase 1 - Homo sapiens (Human) - GNPDA1 gene Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity). Taurus_UMD|evm.model.AC_000170.1.699 P28749 RBL1_HUMAN 94.419 0.457265 0.438202 RBL1 - Retinoblastoma-like protein 1 - Homo sapiens (Human) - RBL1 gene Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). Taurus_UMD|evm.model.AC_000170.1.700 P28749 RBL1_HUMAN 94.567 0.349005 2.07116 RBL1 - Retinoblastoma-like protein 1 - Homo sapiens (Human) - RBL1 gene Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). Taurus_UMD|evm.model.AC_000170.1.701 Q9H579 MROH8_HUMAN 66.151 0.53486 1.98965 MROH8 - Protein MROH8 - Homo sapiens (Human) - MROH8 gene Taurus_UMD|evm.model.AC_000170.1.702 Q3SZI6 RPN2_BOVIN 100.000 0.996835 1.00158 RPN2 - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 precursor - Bos taurus (Bovine) - RPN2 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Taurus_UMD|evm.model.AC_000170.1.703 P63292 SLIB_BOVIN 100.000 0.776923 1.22642 GHRH - Somatoliberin precursor - Bos taurus (Bovine) - GHRH gene GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. Taurus_UMD|evm.model.AC_000170.1.704 Q8TBH0 ARRD2_HUMAN 68.551 0.947368 0.653563 ARRDC2 - Arrestin domain-containing protein 2 - Homo sapiens (Human) - ARRDC2 gene cytoplasm, cytoplasmic vesicle, plasma membrane, protein transport Taurus_UMD|evm.model.AC_000170.1.706 Q9NQG1 MANBL_HUMAN 93.243 0.848837 1.01176 MANBAL - Protein MANBAL - Homo sapiens (Human) - MANBAL gene Taurus_UMD|evm.model.AC_000170.1.708 P12931 SRC_HUMAN 97.048 0.996317 1.01306 SRC - Proto-oncogene tyrosine-protein kinase Src - Homo sapiens (Human) - SRC gene Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:8755529, PubMed:14585963). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances DDX58/RIG-I-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Taurus_UMD|evm.model.AC_000170.1.709 P62950 BLCAP_RAT 100.000 0.977273 1.01149 Blcap - Bladder cancer-associated protein - Rattus norvegicus (Rat) - Blcap gene May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. Taurus_UMD|evm.model.AC_000170.1.710 Q0Q043 NNAT_PIG 100.000 0.544218 1.81481 NNAT - Neuronatin - Sus scrofa (Pig) - NNAT gene May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels (By similarity). Taurus_UMD|evm.model.AC_000170.1.712 O62703 CTBL1_BOVIN 96.540 0.996546 1.02842 CTNNBL1 - Beta-catenin-like protein 1 - Bos taurus (Bovine) - CTNNBL1 gene Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR) (By similarity). Taurus_UMD|evm.model.AC_000170.1.713 Q96N03 VTM2L_HUMAN 98.039 0.990244 1.0049 VSTM2L - V-set and transmembrane domain-containing protein 2-like protein precursor - Homo sapiens (Human) - VSTM2L gene axon, cytoplasm, extracellular region, plasma membrane, cell-cell adhesion mediator activity, axon guidance, dendrite self-avoidance, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of neuron apoptotic process Taurus_UMD|evm.model.AC_000170.1.715 O43156 TTI1_HUMAN 84.982 0.99817 1.00367 TTI1 - TELO2-interacting protein 1 homolog - Homo sapiens (Human) - TTI1 gene Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. Taurus_UMD|evm.model.AC_000170.1.716 Q9NQG5 RPR1B_HUMAN 100.000 0.993884 1.00307 RPRD1B - Regulation of nuclear pre-mRNA domain-containing protein 1B - Homo sapiens (Human) - RPRD1B gene Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. Taurus_UMD|evm.model.AC_000170.1.717 P51176 TGM2_BOVIN 99.854 0.997093 1.00146 TGM2 - Protein-glutamine gamma-glutamyltransferase 2 - Bos taurus (Bovine) - TGM2 gene Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (By similarity). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:9880554). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:9880554). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (By similarity). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (By similarity). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (By similarity). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:25128524). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (By similarity). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (By similarity). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (By similarity). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (By similarity). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (By similarity). May also act as an isopeptidase cleaving the previously formed cross-links (By similarity). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (By similarity). Taurus_UMD|evm.model.AC_000170.1.718 Q5JYT7 K1755_HUMAN 75.417 0.9925 1 KIAA1755 - Uncharacterized protein KIAA1755 - Homo sapiens (Human) - KIAA1755 gene Taurus_UMD|evm.model.AC_000170.1.719 P17453 BPI_BOVIN 99.774 0.988789 0.925311 BPI - Bactericidal permeability-increasing protein precursor - Bos taurus (Bovine) - BPI gene The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Taurus_UMD|evm.model.AC_000170.1.720 Q2TBI0 LBP_BOVIN 94.094 0.996071 1.05821 LBP - Lipopolysaccharide-binding protein precursor - Bos taurus (Bovine) - LBP gene Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide. Taurus_UMD|evm.model.AC_000170.1.721 P18428 LBP_HUMAN 43.281 0.942164 1.11435 LBP - Lipopolysaccharide-binding protein precursor - Homo sapiens (Human) - LBP gene Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359). Taurus_UMD|evm.model.AC_000170.1.723 Q86X10 RLGPB_HUMAN 97.726 0.998658 0.997323 RALGAPB - Ral GTPase-activating protein subunit beta - Homo sapiens (Human) - RALGAPB gene Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. Taurus_UMD|evm.model.AC_000170.1.724 Q2EMW0 ADIG_BOVIN 100.000 0.97561 1.01235 ADIG - Adipogenin - Bos taurus (Bovine) - ADIG gene Plays a role in stimulating adipocyte differentiation and development. Taurus_UMD|evm.model.AC_000170.1.725 O35458 VIAAT_RAT 99.240 0.996205 1.00381 Slc32a1 - Vesicular inhibitory amino acid transporter - Rattus norvegicus (Rat) - Slc32a1 gene Involved in the uptake of GABA and glycine into the synaptic vesicles. Taurus_UMD|evm.model.AC_000170.1.726 Q9H9F9 ARP5_HUMAN 92.422 0.983766 1.01483 ACTR5 - Actin-related protein 5 - Homo sapiens (Human) - ACTR5 gene Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. Taurus_UMD|evm.model.AC_000170.1.727 Q95N27 PP16B_BOVIN 100.000 0.996485 1.00176 PPP1R16B - Protein phosphatase 1 regulatory inhibitor subunit 16B precursor - Bos taurus (Bovine) - PPP1R16B gene Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of the PI3K/AKT signaling pathway (By similarity). Involved in the regulation of angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (PubMed:26806547). Involved in the regulation of endothelial cell filopodia extension (PubMed:17609201). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (By similarity). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (By similarity). Involved in the dephosphorylation of EEF1A1 (By similarity). Taurus_UMD|evm.model.AC_000170.1.728 A3KN19 FA83D_BOVIN 99.828 0.996564 1.00172 FAM83D - Protein FAM83D - Bos taurus (Bovine) - FAM83D gene Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC. May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade. May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22. Taurus_UMD|evm.model.AC_000170.1.729 Q9H5Z1 DHX35_HUMAN 96.439 0.995739 1.00142 DHX35 - Probable ATP-dependent RNA helicase DHX35 - Homo sapiens (Human) - DHX35 gene May be involved in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000170.1.730 Q9Y5Q3 MAFB_HUMAN 98.142 0.993827 1.0031 MAFB - Transcription factor MafB - Homo sapiens (Human) - MAFB gene Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Taurus_UMD|evm.model.AC_000170.1.731 Q7YR26 TOP1_CHLAE 98.309 0.997403 1.00391 TOP1 - DNA topoisomerase 1 - Chlorocebus aethiops (Green monkey) - TOP1 gene Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter. Taurus_UMD|evm.model.AC_000170.1.732 P08487 PLCG1_BOVIN 99.836 0.94786 0.995352 PLCG1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 - Bos taurus (Bovine) - PLCG1 gene Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (By similarity). Taurus_UMD|evm.model.AC_000170.1.733 Q9H4I2 ZHX3_HUMAN 82.218 0.997884 0.988494 ZHX3 - Zinc fingers and homeoboxes protein 3 - Homo sapiens (Human) - ZHX3 gene Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. Taurus_UMD|evm.model.AC_000170.1.735 Q9BQK8 LPIN3_HUMAN 82.864 0.996479 1.00118 LPIN3 - Phosphatidate phosphatase LPIN3 - Homo sapiens (Human) - LPIN3 gene Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism. Taurus_UMD|evm.model.AC_000170.1.736 Q9NT22 EMIL3_HUMAN 85.513 0.990237 0.936031 EMILIN3 - EMILIN-3 precursor - Homo sapiens (Human) - EMILIN3 gene collagen-containing extracellular matrix, extracellular matrix constituent conferring elasticity, identical protein binding Taurus_UMD|evm.model.AC_000170.1.737 Q8TD26 CHD6_HUMAN 86.711 0.999252 0.984899 CHD6 - Chromodomain-helicase-DNA-binding protein 6 - Homo sapiens (Human) - CHD6 gene DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. Taurus_UMD|evm.model.AC_000170.1.738 Q5R893 H2B1_PONAB 93.651 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000170.1.739 O14522 PTPRT_HUMAN 97.922 0.997382 0.795281 PTPRT - Receptor-type tyrosine-protein phosphatase T precursor - Homo sapiens (Human) - PTPRT gene May be involved in both signal transduction and cellular adhesion in the CNS. Taurus_UMD|evm.model.AC_000170.1.741 Q3B7L6 SRSF6_BOVIN 99.310 0.236498 3.54203 SRSF6 - Serine/arginine-rich splicing factor 6 - Bos taurus (Bovine) - SRSF6 gene Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity). Taurus_UMD|evm.model.AC_000170.1.742 Q9HBY8 SGK2_HUMAN 96.185 0.994565 1.00272 SGK2 - Serine/threonine-protein kinase Sgk2 - Homo sapiens (Human) - SGK2 gene Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Taurus_UMD|evm.model.AC_000170.1.743 Q62559 IFT52_MOUSE 92.308 0.94382 0.835681 Ift52 - Intraflagellar transport protein 52 homolog - Mus musculus (Mouse) - Ift52 gene Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia (PubMed:19253336). Required for the anterograde transport of IFT88 (By similarity). Taurus_UMD|evm.model.AC_000170.1.744 P10244 MYBB_HUMAN 88.286 0.997126 0.994286 MYBL2 - Myb-related protein B - Homo sapiens (Human) - MYBL2 gene Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. Taurus_UMD|evm.model.AC_000170.1.745 Q3T026 GTSFL_BOVIN 100.000 0.988235 1.00592 GTSF1L - Gametocyte-specific factor 1-like - Bos taurus (Bovine) - GTSF1L gene Taurus_UMD|evm.model.AC_000170.1.746 Q76IQ7 TOX2_RAT 91.643 0.927461 0.816068 Tox2 - TOX high mobility group box family member 2 - Rattus norvegicus (Rat) - Tox2 gene Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system. Taurus_UMD|evm.model.AC_000170.1.747 Q76IQ7 TOX2_RAT 95.789 0.671429 0.295983 Tox2 - TOX high mobility group box family member 2 - Rattus norvegicus (Rat) - Tox2 gene Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system. Taurus_UMD|evm.model.AC_000170.1.748 Q9GKY7 JPH2_RABIT 100.000 0.0314961 1.09798 JPH2 - Junctophilin-2 - Oryctolagus cuniculus (Rabbit) - JPH2 gene Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes. Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads. Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions. Taurus_UMD|evm.model.AC_000170.1.749 Q5E9A0 OSER1_BOVIN 100.000 0.909091 1.09622 OSER1 - Oxidative stress-responsive serine-rich protein 1 - Bos taurus (Bovine) - OSER1 gene cellular response to hydrogen peroxide Taurus_UMD|evm.model.AC_000170.1.750 Q96MZ0 GD1L1_HUMAN 98.365 0.994565 1.00272 GDAP1L1 - Ganglioside-induced differentiation-associated protein 1-like 1 - Homo sapiens (Human) - GDAP1L1 gene Taurus_UMD|evm.model.AC_000170.1.751 A4IFN5 FITM2_BOVIN 100.000 0.919014 1.08397 FITM2 - Acyl-coenzyme A diphosphatase FITM2 - Bos taurus (Bovine) - FITM2 gene Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates such as oleoyl-CoA/(9Z)-octadecenoyl-CoA and arachidonoyl-CoA/(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Taurus_UMD|evm.model.AC_000170.1.753 A2A5I3 CRSPL_MOUSE 82.213 0.90942 1.09091 R3hdml - Peptidase inhibitor R3HDML precursor - Mus musculus (Mouse) - R3hdml gene Putative serine protease inhibitor. Taurus_UMD|evm.model.AC_000170.1.754 P41235 HNF4A_HUMAN 97.890 0.995789 1.00211 HNF4A - Hepatocyte nuclear factor 4-alpha - Homo sapiens (Human) - HNF4A gene Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). Taurus_UMD|evm.model.AC_000170.1.756 Q5RFR0 TTPAL_PONAB 91.813 0.994169 1.00292 TTPAL - Alpha-tocopherol transfer protein-like - Pongo abelii (Sumatran orangutan) - TTPAL gene May act as a protein that binds a hydrophobic ligand. Taurus_UMD|evm.model.AC_000170.1.757 A4FUZ5 SERC3_BOVIN 100.000 0.995772 1.00212 SERINC3 - Serine incorporator 3 - Bos taurus (Bovine) - SERINC3 gene Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm. Taurus_UMD|evm.model.AC_000170.1.758 Q7YQJ3 IPKG_BOVIN 98.684 0.714286 1.38158 PKIG - cAMP-dependent protein kinase inhibitor gamma - Bos taurus (Bovine) - PKIG gene Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Taurus_UMD|evm.model.AC_000170.1.759 P56658 ADA_BOVIN 99.449 0.994505 1.00275 ADA - Adenosine deaminase - Bos taurus (Bovine) - ADA gene Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (By similarity). Plays an important role in purine metabolism and in adenosine homeostasis (By similarity). Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (By similarity). Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (PubMed:23240012). Enhances CD4+ T-cell differentiation and proliferation (By similarity). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity). Stimulates plasminogen activation (By similarity). Plays a role in male fertility (By similarity). Plays a protective role in early postimplantation embryonic development (By similarity). Taurus_UMD|evm.model.AC_000170.1.760 O76076 CCN5_HUMAN 86.000 0.992032 1.004 CCN5 - CCN family member 5 precursor - Homo sapiens (Human) - CCN5 gene May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production. Taurus_UMD|evm.model.AC_000170.1.761 Q8R5I0 KCNKF_RAT 81.346 0.993789 1.01258 Kcnk15 - Potassium channel subfamily K member 15 - Rattus norvegicus (Rat) - Kcnk15 gene Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel. Taurus_UMD|evm.model.AC_000170.1.762 Q9H426 RIMS4_HUMAN 100.000 0.990783 0.806691 RIMS4 - Regulating synaptic membrane exocytosis protein 4 - Homo sapiens (Human) - RIMS4 gene Regulates synaptic membrane exocytosis. Taurus_UMD|evm.model.AC_000170.1.763 A4K2U9 1433B_PONAB 100.000 0.991903 1.00407 YWHAB - 14-3-3 protein beta/alpha - Pongo abelii (Sumatran orangutan) - YWHAB gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. Taurus_UMD|evm.model.AC_000170.1.764 Q4VXU2 PAP1L_HUMAN 87.765 0.98546 1.00814 PABPC1L - Polyadenylate-binding protein 1-like - Homo sapiens (Human) - PABPC1L gene cytoplasmic stress granule, cytosol, extracellular exosome, nucleus, ribonucleoprotein complex, mRNA 3'-UTR binding, poly(A) binding, poly(U) RNA binding, RNA binding Taurus_UMD|evm.model.AC_000170.1.765 Q15785 TOM34_HUMAN 83.172 0.993548 1.00324 TOMM34 - Mitochondrial import receptor subunit TOM34 - Homo sapiens (Human) - TOMM34 gene Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. Taurus_UMD|evm.model.AC_000170.1.766 Q5E9L6 STK4_BOVIN 100.000 0.995902 1.00205 STK4 - Serine/threonine-protein kinase 4 - Bos taurus (Bovine) - STK4 gene Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. Taurus_UMD|evm.model.AC_000170.1.767 A4K2X4 KCNS1_SAIBB 93.964 0.993988 0.943289 KCNS1 - Potassium voltage-gated channel subfamily S member 1 - Saimiri boliviensis boliviensis (Bolivian squirrel monkey) - KCNS1 gene Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Taurus_UMD|evm.model.AC_000170.1.768 A4K2X5 WFDC5_SAIBB 74.380 0.983607 0.99187 WFDC5 - WAP four-disulfide core domain protein 5 precursor - Saimiri boliviensis boliviensis (Bolivian squirrel monkey) - WFDC5 gene Putative acid-stable proteinase inhibitor. Taurus_UMD|evm.model.AC_000170.1.769 P22075 CALU_CAVPO 53.488 0.336 2.27273 Caltrin-like protein 2 - Cavia porcellus (Guinea pig) Taurus_UMD|evm.model.AC_000170.1.770 P22075 CALU_CAVPO 53.488 0.336 2.27273 Caltrin-like protein 2 - Cavia porcellus (Guinea pig) Taurus_UMD|evm.model.AC_000170.1.771 Q3UW55 WFC6A_MOUSE 53.333 0.328358 0.985294 Wfdc6a - WAP four-disulfide core domain protein 6A precursor - Mus musculus (Mouse) - Wfdc6a gene cell surface, extracellular space, protein-containing complex, defense response to bacterium, negative regulation of calcium ion import, negative regulation of flagellated sperm motility, negative regulation of peptidase activity Taurus_UMD|evm.model.AC_000170.1.772 Q29125 ELAF_PIG 61.047 0.988439 1.03593 Elafin precursor - Sus scrofa (Pig) Taurus_UMD|evm.model.AC_000170.1.773 P03973 SLPI_HUMAN 55.303 0.922535 1.07576 SLPI - Antileukoproteinase precursor - Homo sapiens (Human) - SLPI gene Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563, PubMed:10702419, PubMed:24121345). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:10702419, PubMed:24352879). Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (PubMed:24352879). Taurus_UMD|evm.model.AC_000170.1.774 Q6V9X0 SLPI_SHEEP 85.606 0.984848 1 SLPI - Antileukoproteinase precursor - Ovis aries (Sheep) - SLPI gene Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (By similarity). Taurus_UMD|evm.model.AC_000170.1.775 P62278 RS13_RAT 87.919 0.880952 1.11258 Rps13 - 40S ribosomal protein S13 - Rattus norvegicus (Rat) - Rps13 gene cytosolic small ribosomal subunit, nucleolus, nucleus, postsynaptic density, synapse, 5.8S rRNA binding, mRNA 5'-UTR binding, mRNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome Taurus_UMD|evm.model.AC_000170.1.776 O95460 MATN4_HUMAN 85.690 0.936426 0.935691 MATN4 - Matrilin-4 precursor - Homo sapiens (Human) - MATN4 gene Major component of the extracellular matrix of cartilage. Taurus_UMD|evm.model.AC_000170.1.777 Q9UBG7 RBPJL_HUMAN 89.768 0.996139 1.00193 RBPJL - Recombining binding protein suppressor of hairless-like protein - Homo sapiens (Human) - RBPJL gene Putative transcription factor, which cooperates with EBNA2 to activate transcription. Taurus_UMD|evm.model.AC_000170.1.778 Q8HZJ6 SDC4_PIG 86.634 0.99 0.990099 SDC4 - Syndecan-4 precursor - Sus scrofa (Pig) - SDC4 gene Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Taurus_UMD|evm.model.AC_000170.1.780 Q1RMQ3 SYS1_BOVIN 100.000 0.987261 1.00641 SYS1 - Protein SYS1 homolog - Bos taurus (Bovine) - SYS1 gene Involved in protein trafficking. May serve as a receptor for ARFRP1 (By similarity). Taurus_UMD|evm.model.AC_000170.1.781 Q9Y2B4 T53G5_HUMAN 57.752 0.96063 0.875862 TP53TG5 - TP53-target gene 5 protein - Homo sapiens (Human) - TP53TG5 gene May play a significant role in p53/TP53-mediating signaling pathway. Taurus_UMD|evm.model.AC_000170.1.782 P30050 RL12_HUMAN 72.024 0.986928 0.927273 RPL12 - 60S ribosomal protein L12 - Homo sapiens (Human) - RPL12 gene Binds directly to 26S ribosomal RNA. Taurus_UMD|evm.model.AC_000170.1.783 Q9CRD4 DBND2_MOUSE 77.640 0.987342 1 Dbndd2 - Dysbindin domain-containing protein 2 - Mus musculus (Mouse) - Dbndd2 gene May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro) (By similarity). Taurus_UMD|evm.model.AC_000170.1.784 Q969N2 PIGT_HUMAN 93.560 0.963731 1.00173 PIGT - GPI transamidase component PIG-T precursor - Homo sapiens (Human) - PIGT gene Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. Taurus_UMD|evm.model.AC_000170.1.785 P00976 IBPC_BOVIN 89.062 0.417219 2.25373 Colostrum trypsin inhibitor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.786 Q9Y2W2 WBP11_HUMAN 91.051 0.69279 0.99532 WBP11 - WW domain-binding protein 11 - Homo sapiens (Human) - WBP11 gene Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. Taurus_UMD|evm.model.AC_000170.1.787 P00975 IBPS_BOVIN 55.357 0.354839 2.58333 Serum basic protease inhibitor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.788 P00975 IBPS_BOVIN 57.143 0.164251 3.45 Serum basic protease inhibitor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.789 Q29428 TKDP1_SHEEP 85.500 0.172893 4.3434 TKDP1 - Trophoblast Kunitz domain protein 1 precursor - Ovis aries (Sheep) - TKDP1 gene May play a role in mediating maternal-conceptus interactions in the immediate preimplantation period. Does not seem to have proteinase inhibitory activity. Taurus_UMD|evm.model.AC_000170.1.791 Q28201 TKDP1_BOVIN 71.875 0.183432 0.481481 TKDP1 - Trophoblast Kunitz domain protein 1 precursor - Bos taurus (Bovine) - TKDP1 gene May play a role in mediating maternal-conceptus interactions in the immediate preimplantation period. Does not seem to have proteinase inhibitory activity (By similarity). Taurus_UMD|evm.model.AC_000170.1.792 Q29428 TKDP1_SHEEP 71.875 0.252033 0.464151 TKDP1 - Trophoblast Kunitz domain protein 1 precursor - Ovis aries (Sheep) - TKDP1 gene May play a role in mediating maternal-conceptus interactions in the immediate preimplantation period. Does not seem to have proteinase inhibitory activity. Taurus_UMD|evm.model.AC_000170.1.793 P04815 BPT2_BOVIN 98.969 0.243038 3.95 Spleen trypsin inhibitor I precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.794 Q08DY8 ATG13_BOVIN 90.076 0.573333 0.46875 ATG13 - Autophagy-related protein 13 - Bos taurus (Bovine) - ATG13 gene Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. Taurus_UMD|evm.model.AC_000170.1.795 Q08DY8 ATG13_BOVIN 92.248 0.581818 0.458333 ATG13 - Autophagy-related protein 13 - Bos taurus (Bovine) - ATG13 gene Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. Taurus_UMD|evm.model.AC_000170.1.796 P00974 BPT1_BOVIN 96.739 0.875 1.04 Pancreatic trypsin inhibitor precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.797 P00975 IBPS_BOVIN 55.357 0.284974 3.21667 Serum basic protease inhibitor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.798 P00975 IBPS_BOVIN 66.667 0.513761 1.81667 Serum basic protease inhibitor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000170.1.799 Q8MI69 WFDC2_PIG 76.423 0.983871 1.00813 WFDC2 - WAP four-disulfide core domain protein 2 precursor - Sus scrofa (Pig) - WFDC2 gene Broad range protease inhibitor. Taurus_UMD|evm.model.AC_000170.1.800 Q9BDL1 EPPI_MACMU 61.000 0.332215 2.2406 EPPIN - Eppin precursor - Macaca mulatta (Rhesus macaque) - EPPIN gene Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (By similarity). Taurus_UMD|evm.model.AC_000170.1.802 D0VWQ3 RL18_CANLF 81.034 0.360759 0.840426 RPL18 - Ribosomal protein L18 - Canis lupus familiaris (Dog) - RPL18 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000170.1.803 Q8IUB2 WFDC3_HUMAN 87.209 0.429293 0.857143 WFDC3 - WAP four-disulfide core domain protein 3 precursor - Homo sapiens (Human) - WFDC3 gene extracellular space, serine-type endopeptidase inhibitor activity, antibacterial humoral response, innate immune response Taurus_UMD|evm.model.AC_000170.1.804 A6H7A8 TDIF1_BOVIN 100.000 0.993939 1.00304 DNTTIP1 - Deoxynucleotidyltransferase terminal-interacting protein 1 - Bos taurus (Bovine) - DNTTIP1 gene Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA. Taurus_UMD|evm.model.AC_000170.1.805 Q32PA5 UBE2C_BOVIN 100.000 0.988889 1.00559 UBE2C - Ubiquitin-conjugating enzyme E2 C - Bos taurus (Bovine) - UBE2C gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Taurus_UMD|evm.model.AC_000170.1.806 P02585 TNNC2_HUMAN 94.595 0.839695 0.81875 TNNC2 - Troponin C, skeletal muscle - Homo sapiens (Human) - TNNC2 gene Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Taurus_UMD|evm.model.AC_000170.1.807 Q969T3 SNX21_HUMAN 85.714 0.398927 1.49866 SNX21 - Sorting nexin-21 - Homo sapiens (Human) - SNX21 gene Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking. Taurus_UMD|evm.model.AC_000170.1.809 Q9BR11 ZSWM1_HUMAN 81.140 0.995624 0.942268 ZSWIM1 - Zinc finger SWIM domain-containing protein 1 - Homo sapiens (Human) - ZSWIM1 gene Taurus_UMD|evm.model.AC_000170.1.810 Q9BR10 SPT25_HUMAN 72.247 0.990868 0.964758 SPATA25 - Spermatogenesis-associated protein 25 - Homo sapiens (Human) - SPATA25 gene May play a role in spermatogenesis. Taurus_UMD|evm.model.AC_000170.1.811 Q9BR09 NEUL2_HUMAN 93.684 0.993007 1.00351 NEURL2 - Neuralized-like protein 2 - Homo sapiens (Human) - NEURL2 gene Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity). Taurus_UMD|evm.model.AC_000170.1.812 Q3MI05 PPGB_BOVIN 100.000 0.995833 1.00209 CTSA - Lysosomal protective protein precursor - Bos taurus (Bovine) - CTSA gene Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins (By similarity). Taurus_UMD|evm.model.AC_000170.1.813 P55058 PLTP_HUMAN 90.021 0.965795 1.00811 PLTP - Phospholipid transfer protein precursor - Homo sapiens (Human) - PLTP gene Mediates the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low density lipoproteins or LDL and very low density lipoproteins or VLDL) into high-density lipoproteins (HDL) as well as the exchange of phospholipids between triglyceride-rich lipoproteins themselves (PubMed:7654777, PubMed:9132017, PubMed:11013307, PubMed:19321130, PubMed:21515415, PubMed:29883800). Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine (PubMed:9132017). Plays an important role in HDL remodeling which involves modulating the size and composition of HDL (PubMed:29883800). Also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion (PubMed:21736953). Two distinct forms of PLTP exist in plasma: an active form that can transfer phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form that lacks this capability (PubMed:11013307). Taurus_UMD|evm.model.AC_000170.1.815 Q9H4Z3 CAPAM_HUMAN 96.733 0.997155 0.99858 PCIF1 - mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase - Homo sapiens (Human) - PCIF1 gene Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178). Taurus_UMD|evm.model.AC_000170.1.816 Q9H4Z2 ZN335_HUMAN 89.599 0.998511 1.00075 ZNF335 - Zinc finger protein 335 - Homo sapiens (Human) - ZNF335 gene Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). Taurus_UMD|evm.model.AC_000170.1.817 P52176 MMP9_BOVIN 99.860 0.997195 1.0014 MMP9 - Matrix metalloproteinase-9 precursor - Bos taurus (Bovine) - MMP9 gene Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (By similarity). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond (By similarity). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (By similarity). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide (By similarity). Taurus_UMD|evm.model.AC_000170.1.818 Q9H2X9 S12A5_HUMAN 97.719 0.998247 1.00176 SLC12A5 - Solute carrier family 12 member 5 - Homo sapiens (Human) - SLC12A5 gene Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262). Taurus_UMD|evm.model.AC_000170.1.819 Q9HCD5 NCOA5_HUMAN 94.128 0.996552 1.00173 NCOA5 - Nuclear receptor coactivator 5 - Homo sapiens (Human) - NCOA5 gene Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). Taurus_UMD|evm.model.AC_000170.1.821 Q28203 TNR5_BOVIN 99.643 0.992883 1.00357 CD40 - Tumor necrosis factor receptor superfamily member 5 precursor - Bos taurus (Bovine) - CD40 gene Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). Taurus_UMD|evm.model.AC_000170.1.823 Q9UJ99 CAD22_HUMAN 90.036 0.997468 0.954106 CDH22 - Cadherin-22 precursor - Homo sapiens (Human) - CDH22 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity). Taurus_UMD|evm.model.AC_000170.1.824 Q9NQQ7 S35C2_HUMAN 82.353 0.994413 0.980822 SLC35C2 - Solute carrier family 35 member C2 - Homo sapiens (Human) - SLC35C2 gene May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. Taurus_UMD|evm.model.AC_000170.1.825 A4FUD6 ELMO2_BOVIN 99.861 0.997226 1.00139 ELMO2 - Engulfment and cell motility protein 2 - Bos taurus (Bovine) - ELMO2 gene Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). Taurus_UMD|evm.model.AC_000170.1.826 A6NDX5 ZN840_HUMAN 64.068 0.992172 0.713687 ZNF840P - Putative zinc finger protein 840 - Homo sapiens (Human) - ZNF840P gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000170.1.827 O93603 TRFR_CHICK 54.303 0.901907 0.929114 TRHR - Thyrotropin-releasing hormone receptor - Gallus gallus (Chicken) - TRHR gene Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. Taurus_UMD|evm.model.AC_000170.1.828 Q9BR26 OCSTP_HUMAN 75.817 0.966102 0.833922 OCSTAMP - Osteoclast stimulatory transmembrane protein - Homo sapiens (Human) - OCSTAMP gene Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity). Taurus_UMD|evm.model.AC_000170.1.829 Q8WWT9 S13A3_HUMAN 89.037 0.996683 1.00166 SLC13A3 - Solute carrier family 13 member 3 - Homo sapiens (Human) - SLC13A3 gene High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, including succinate, alpha-ketoglutarate and N-acetylaspartate (PubMed:30635937). The stoichiometry is probably 3 Na(+) for 1 divalent succinate. Taurus_UMD|evm.model.AC_000170.1.831 Q96S44 PRPK_HUMAN 88.538 0.992126 1.00395 TP53RK - EKC/KEOPS complex subunit TP53RK - Homo sapiens (Human) - TP53RK gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806). Taurus_UMD|evm.model.AC_000170.1.832 O95528 GTR10_HUMAN 81.701 0.996276 0.992606 SLC2A10 - Solute carrier family 2, facilitated glucose transporter member 10 - Homo sapiens (Human) - SLC2A10 gene Facilitative glucose transporter required for the development of the cardiovascular system. Taurus_UMD|evm.model.AC_000170.1.833 Q58DB6 EYA2_BOVIN 100.000 0.7507 1.32961 EYA2 - Eyes absent homolog 2 - Bos taurus (Bovine) - EYA2 gene Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1. Taurus_UMD|evm.model.AC_000170.1.834 Q9ULU4 PKCB1_HUMAN 90.663 0.982272 1.04637 ZMYND8 - Protein kinase C-binding protein 1 - Homo sapiens (Human) - ZMYND8 gene May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion. Taurus_UMD|evm.model.AC_000170.1.835 Q9Y6Q9 NCOA3_HUMAN 89.238 0.998583 0.990871 NCOA3 - Nuclear receptor coactivator 3 - Homo sapiens (Human) - NCOA3 gene Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Taurus_UMD|evm.model.AC_000170.1.837 Q8IWU5 SULF2_HUMAN 94.483 0.997691 0.995402 SULF2 - Extracellular sulfatase Sulf-2 precursor - Homo sapiens (Human) - SULF2 gene Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Taurus_UMD|evm.model.AC_000170.1.840 P52732 KIF11_HUMAN 80.749 0.934066 0.172348 KIF11 - Kinesin-like protein KIF11 - Homo sapiens (Human) - KIF11 gene Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). Taurus_UMD|evm.model.AC_000170.1.841 Q8TCU6 PREX1_HUMAN 93.644 0.998739 0.955998 PREX1 - Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein - Homo sapiens (Human) - PREX1 gene Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. Taurus_UMD|evm.model.AC_000170.1.842 Q9Y6D5 BIG2_HUMAN 96.583 0.998876 0.997199 ARFGEF2 - Brefeldin A-inhibited guanine nucleotide-exchange protein 2 - Homo sapiens (Human) - ARFGEF2 gene Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Taurus_UMD|evm.model.AC_000170.1.843 O46415 FRIL_BOVIN 82.286 0.986755 0.862857 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000170.1.844 A5D785 XPO2_BOVIN 99.897 0.997942 1.00103 CSE1L - Exportin-2 - Bos taurus (Bovine) - CSE1L gene Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Taurus_UMD|evm.model.AC_000170.1.845 O95793 STAU1_HUMAN 95.285 0.755952 1.16464 STAU1 - Double-stranded RNA-binding protein Staufen homolog 1 - Homo sapiens (Human) - STAU1 gene Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. Taurus_UMD|evm.model.AC_000170.1.846 A1A4H6 DDX27_BOVIN 100.000 0.997389 1.00131 DDX27 - Probable ATP-dependent RNA helicase DDX27 - Bos taurus (Bovine) - DDX27 gene Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA. Taurus_UMD|evm.model.AC_000170.1.847 Q9P2E3 ZNFX1_HUMAN 88.854 0.998958 1.00052 ZNFX1 - NFX1-type zinc finger-containing protein 1 - Homo sapiens (Human) - ZNFX1 gene nuclear RNA-directed RNA polymerase complex, RNA binding, heterochromatin assembly by small RNA Taurus_UMD|evm.model.AC_000170.1.849 O18868 KCNB1_PIG 98.368 0.997672 1.00117 KCNB1 - Potassium voltage-gated channel subfamily B member 1 - Sus scrofa (Pig) - KCNB1 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (By similarity). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells. Channel properties are also modulated by cytoplasmic ancillary beta subunits, such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus. Contributes to the regulation of the glucose-induced amplitude and duration of action potentials in pancreatic beta-cells, hence limiting calcium influx and insulin secretion. Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions. Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits. Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner. Taurus_UMD|evm.model.AC_000170.1.850 Q29626 PTGIS_BOVIN 100.000 0.996008 1.002 PTGIS - Prostacyclin synthase - Bos taurus (Bovine) - PTGIS gene Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:8051072, PubMed:8280118). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (By similarity). Taurus_UMD|evm.model.AC_000170.1.852 A0A1S6M251 B4GT5_PIG 96.011 0.921053 0.979381 B4GALT5 - Beta-1,4-galactosyltransferase 5 - Sus scrofa (Pig) - B4GALT5 gene Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (By similarity). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity). Taurus_UMD|evm.model.AC_000170.1.853 Q9Y2E8 SL9A8_HUMAN 97.059 0.99651 0.986231 SLC9A8 - Sodium/hydrogen exchanger 8 - Homo sapiens (Human) - SLC9A8 gene Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Taurus_UMD|evm.model.AC_000170.1.854 Q9UM82 SPAT2_HUMAN 83.525 0.996139 0.996154 SPATA2 - Spermatogenesis-associated protein 2 - Homo sapiens (Human) - SPATA2 gene Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity). Taurus_UMD|evm.model.AC_000170.1.856 Q4U5R4 RN114_BOVIN 100.000 0.991342 1.00435 RNF114 - E3 ubiquitin-protein ligase RNF114 - Bos taurus (Bovine) - RNF114 gene E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation. Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C. This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis. Taurus_UMD|evm.model.AC_000170.1.857 O95863 SNAI1_HUMAN 87.500 0.900685 1.10606 SNAI1 - Zinc finger protein SNAI1 - Homo sapiens (Human) - SNAI1 gene Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. Taurus_UMD|evm.model.AC_000170.1.858 Q13404 UB2V1_HUMAN 100.000 0.986486 1.0068 UBE2V1 - Ubiquitin-conjugating enzyme E2 variant 1 - Homo sapiens (Human) - UBE2V1 gene Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed:31006531). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. Taurus_UMD|evm.model.AC_000170.1.859 A6QLM0 PDES1_BOVIN 100.000 0.832727 1.01476 PEDS1 - Plasmanylethanolamine desaturase - Bos taurus (Bovine) - PEDS1 gene Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane. Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms. Taurus_UMD|evm.model.AC_000170.1.861 P18031 PTN1_HUMAN 88.028 0.888889 1.07586 PTPN1 - Tyrosine-protein phosphatase non-receptor type 1 - Homo sapiens (Human) - PTPN1 gene Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. Taurus_UMD|evm.model.AC_000170.1.862 Q96MK2 RIPR3_HUMAN 83.738 0.95846 1.04334 RIPOR3 - RIPOR family member 3 - Homo sapiens (Human) - RIPOR3 gene Taurus_UMD|evm.model.AC_000170.1.863 Q9BYG5 PAR6B_HUMAN 89.008 0.994652 1.00538 PARD6B - Partitioning defective 6 homolog beta - Homo sapiens (Human) - PARD6B gene Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Taurus_UMD|evm.model.AC_000170.1.864 Q8TDM0 BCAS4_HUMAN 80.142 0.848485 0.781991 BCAS4 - Breast carcinoma-amplified sequence 4 - Homo sapiens (Human) - BCAS4 gene BLOC-1 complex Taurus_UMD|evm.model.AC_000170.1.865 Q9H2P0 ADNP_HUMAN 96.555 0.998187 1.00091 ADNP - Activity-dependent neuroprotector homeobox protein - Homo sapiens (Human) - ADNP gene Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Taurus_UMD|evm.model.AC_000170.1.866 Q1JQ93 DPM1_BOVIN 99.615 0.992337 1.00385 DPM1 - Dolichol-phosphate mannosyltransferase subunit 1 - Bos taurus (Bovine) - DPM1 gene Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. Taurus_UMD|evm.model.AC_000170.1.867 A1A4L8 MOCS3_BOVIN 100.000 0.970085 1.02857 MOCS3 - Adenylyltransferase and sulfurtransferase MOCS3 - Bos taurus (Bovine) - MOCS3 gene Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. Taurus_UMD|evm.model.AC_000170.1.868 Q9UIX4 KCNG1_HUMAN 93.969 0.996117 1.0039 KCNG1 - Potassium voltage-gated channel subfamily G member 1 - Homo sapiens (Human) - KCNG1 gene Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135). Taurus_UMD|evm.model.AC_000170.1.869 Q13469 NFAC2_HUMAN 92.216 0.997824 0.993514 NFATC2 - Nuclear factor of activated T-cells, cytoplasmic 2 - Homo sapiens (Human) - NFATC2 gene Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway. Taurus_UMD|evm.model.AC_000170.1.870 O75110 ATP9A_HUMAN 98.002 0.997899 0.909265 ATP9A - Probable phospholipid-transporting ATPase IIA - Homo sapiens (Human) - ATP9A gene Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling and endosome to trans-Golgi network retrograde transport (PubMed:27733620, PubMed:30213940). In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation (PubMed:30213940). Appears to be implicated in intercellular communication by negatively regulating the release of exosomes (PubMed:30947313). The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved (PubMed:30947313). Taurus_UMD|evm.model.AC_000170.1.872 Q9UJQ4 SALL4_HUMAN 79.699 0.998117 1.00855 SALL4 - Sal-like protein 4 - Homo sapiens (Human) - SALL4 gene Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells. Taurus_UMD|evm.model.AC_000170.1.874 Q86UF2 CTGE6_HUMAN 41.892 0.416185 0.445302 CTAGE6 - cTAGE family member 6 - Homo sapiens (Human) - CTAGE6 gene endoplasmic reticulum exit site, endoplasmic reticulum membrane, endoplasmic reticulum to Golgi vesicle-mediated transport, protein secretion, vesicle cargo loading Taurus_UMD|evm.model.AC_000170.1.875 Q9NTW7 ZF64B_HUMAN 86.486 0.95082 0.662016 ZFP64 - Zinc finger protein 64 - Homo sapiens (Human) - ZFP64 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000170.1.876 Q9NTW7 ZF64B_HUMAN 64.660 0.552129 1.05581 ZFP64 - Zinc finger protein 64 - Homo sapiens (Human) - ZFP64 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000170.1.879 A5GFT6 TSH2_PIG 92.483 0.836785 1.16618 TSHZ2 - Teashirt homolog 2 - Sus scrofa (Pig) - TSHZ2 gene Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Taurus_UMD|evm.model.AC_000170.1.881 O75362 ZN217_HUMAN 62.629 0.997984 0.946565 ZNF217 - Zinc finger protein 217 - Homo sapiens (Human) - ZNF217 gene Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. Taurus_UMD|evm.model.AC_000170.1.883 O75363 BCAS1_HUMAN 63.679 0.918797 1.1387 BCAS1 - Breast carcinoma-amplified sequence 1 - Homo sapiens (Human) - BCAS1 gene Required for myelination. Taurus_UMD|evm.model.AC_000170.1.885 Q07973 CP24A_HUMAN 87.160 0.996117 1.00195 CYP24A1 - 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor - Homo sapiens (Human) - CYP24A1 gene A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:24893882, PubMed:15574355, PubMed:8679605, PubMed:11012668, PubMed:16617161, PubMed:29461981). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid (PubMed:24893882, PubMed:15574355). With initial hydroxylation at C-23 (via C23-oxidation pathway), catalyzes sequential oxidation of calcidiol leading to the formation of 25(OH)D3-26,23-lactone as end product (PubMed:11012668, PubMed:8679605). Preferentially hydroxylates at C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol (PubMed:25727742). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:8679605). Taurus_UMD|evm.model.AC_000170.1.886 Q2TBR6 PFD4_BOVIN 99.213 0.639594 1.47015 PFDN4 - Prefoldin subunit 4 - Bos taurus (Bovine) - PFDN4 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Taurus_UMD|evm.model.AC_000170.1.888 Q9P104 DOK5_HUMAN 93.574 0.813115 0.996732 DOK5 - Docking protein 5 - Homo sapiens (Human) - DOK5 gene DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. Taurus_UMD|evm.model.AC_000170.1.893 Q9NTU7 CBLN4_HUMAN 95.522 0.990099 1.00498 CBLN4 - Cerebellin-4 precursor - Homo sapiens (Human) - CBLN4 gene Acts as a synaptic organizer in specific subsets of neurons in the brain (By similarity). Essential for the formation and maintenance of inhibitory GABAergic synapses (By similarity). Promotes the development of dendrite-targeting inhibitory GABAergic synapses made by somatostatin-positive interneurons (By similarity). May contribute to the function of ventral medial habenula region of the brain implicated in the regulation of anxiety-related behaviors (By similarity). May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity). Taurus_UMD|evm.model.AC_000171.1.1 Q13136 LIPA1_HUMAN 75.000 0.282609 0.191348 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000171.1.2 Q13136 LIPA1_HUMAN 89.189 0.227848 0.131448 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000171.1.3 Q13136 LIPA1_HUMAN 82.609 0.0922432 0.396839 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000171.1.4 Q8IX29 FBX16_HUMAN 78.082 0.967742 0.212329 FBXO16 - F-box only protein 16 - Homo sapiens (Human) - FBXO16 gene Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Taurus_UMD|evm.model.AC_000171.1.7 Q9NPG1 FZD3_HUMAN 82.759 0.0717949 0.585586 FZD3 - Frizzled-3 precursor - Homo sapiens (Human) - FZD3 gene Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000171.1.8 Q13136 LIPA1_HUMAN 73.864 0.966667 0.0748752 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000171.1.9 Q13136 LIPA1_HUMAN 62.416 0.65847 0.304493 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000171.1.11 Q8BSS9 LIPA2_MOUSE 81.818 0.0284192 0.895784 Ppfia2 - Liprin-alpha-2 - Mus musculus (Mouse) - Ppfia2 gene Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines. Taurus_UMD|evm.model.AC_000171.1.12 Q13136 LIPA1_HUMAN 56.275 0.821739 0.191348 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000171.1.13 Q8NGL4 OR5DD_HUMAN 72.816 0.980769 0.33121 OR5D13 - Olfactory receptor 5D13 - Homo sapiens (Human) - OR5D13 gene Odorant receptor. Taurus_UMD|evm.model.AC_000171.1.14 Q9UPS8 ANR26_HUMAN 63.743 0.958904 0.597661 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000171.1.15 Q7TNU6 ZN250_MOUSE 78.505 0.994413 1.00374 Znf250 - Zinc finger protein 250 - Mus musculus (Mouse) - Znf250 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000171.1.16 A1YG88 ZNF16_PANPA 75.083 0.965232 0.897474 ZNF16 - Zinc finger protein 16 - Pan paniscus (Pygmy chimpanzee) - ZNF16 gene Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis (By similarity). Taurus_UMD|evm.model.AC_000171.1.18 Q2KID8 CH033_BOVIN 99.468 0.989418 1.00532 UPF0488 protein C8orf33 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000171.1.19 A3KN32 ZNF34_BOVIN 99.816 0.996324 1.00184 ZNF34 - Zinc finger protein 34 - Bos taurus (Bovine) - ZNF34 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000171.1.20 P62919 RL8_RAT 100.000 0.992248 1.00389 Rpl8 - 60S ribosomal protein L8 - Rattus norvegicus (Rat) - Rpl8 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000171.1.21 P17097 ZNF7_HUMAN 79.826 0.965517 1.01458 ZNF7 - Zinc finger protein 7 - Homo sapiens (Human) - ZNF7 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000171.1.22 Q5E9K1 COMD5_BOVIN 100.000 0.991111 1.00446 COMMD5 - COMM domain-containing protein 5 - Bos taurus (Bovine) - COMMD5 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B. Taurus_UMD|evm.model.AC_000171.1.24 P18890 RHG39_RAT 98.020 0.0863558 11.4653 Arhgap39 - Rho GTPase-activating protein 39 - Rattus norvegicus (Rat) - Arhgap39 gene cytoplasm, glutamatergic synapse, postsynapse, GTPase activator activity, postsynapse organization Taurus_UMD|evm.model.AC_000171.1.25 A8E4L3 CH082_BOVIN 100.000 0.943478 1.05505 UPF0598 protein C8orf82 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000171.1.26 Q50LG9 LRC24_HUMAN 85.947 0.834483 1.1306 LRRC24 - Leucine-rich repeat-containing protein 24 precursor - Homo sapiens (Human) - LRRC24 gene extracellular matrix, extracellular space Taurus_UMD|evm.model.AC_000171.1.27 A5PJJ5 LRC14_BOVIN 100.000 0.995951 1.00203 LRRC14 - Leucine-rich repeat-containing protein 14 - Bos taurus (Bovine) - LRRC14 gene Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB. Taurus_UMD|evm.model.AC_000171.1.28 O94761 RECQ4_HUMAN 65.308 0.998359 1.00911 RECQL4 - ATP-dependent DNA helicase Q4 - Homo sapiens (Human) - RECQL4 gene DNA-dependent ATPase. May modulate chromosome segregation. Taurus_UMD|evm.model.AC_000171.1.29 Q96ES6 MFSD3_HUMAN 77.129 0.987952 1.00728 MFSD3 - Major facilitator superfamily domain-containing protein 3 - Homo sapiens (Human) - MFSD3 gene solute:proton symporter activity Taurus_UMD|evm.model.AC_000171.1.31 A4IFH5 ALAT1_BOVIN 100.000 0.488648 2.04234 GPT - Alanine aminotransferase 1 - Bos taurus (Bovine) - GPT gene Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). Taurus_UMD|evm.model.AC_000171.1.32 O75593 FOXH1_HUMAN 81.744 0.99446 0.989041 FOXH1 - Forkhead box protein H1 - Homo sapiens (Human) - FOXH1 gene Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). Taurus_UMD|evm.model.AC_000171.1.33 Q96AC6 KIFC2_HUMAN 83.994 0.822144 1.01313 KIFC2 - Kinesin-like protein KIFC2 - Homo sapiens (Human) - KIFC2 gene May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity). Taurus_UMD|evm.model.AC_000171.1.34 Q6ZMK1 CYHR1_HUMAN 93.923 0.99449 1.00276 CYHR1 - Cysteine and histidine-rich protein 1 - Homo sapiens (Human) - CYHR1 gene nucleoplasm Taurus_UMD|evm.model.AC_000171.1.35 Q0P5G1 TONSL_BOVIN 100.000 0.998545 1.00073 TONSL - Tonsoku-like protein - Bos taurus (Bovine) - TONSL gene Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold (By similarity). Taurus_UMD|evm.model.AC_000171.1.36 Q3T178 VPS28_BOVIN 79.186 0.989011 0.823529 VPS28 - Vacuolar protein sorting-associated protein 28 homolog - Bos taurus (Bovine) - VPS28 gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Taurus_UMD|evm.model.AC_000171.1.37 Q1KZG0 S39A4_BOVIN 100.000 0.996942 1.00153 SLC39A4 - Zinc transporter ZIP4 precursor - Bos taurus (Bovine) - SLC39A4 gene Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity). Taurus_UMD|evm.model.AC_000171.1.38 Q10569 CPSF1_BOVIN 100.000 0.953734 1.04778 CPSF1 - Cleavage and polyadenylation specificity factor subunit 1 - Bos taurus (Bovine) - CPSF1 gene Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). Taurus_UMD|evm.model.AC_000171.1.39 Q3MIX3 ADCK5_HUMAN 84.174 0.889922 1.11207 ADCK5 - Uncharacterized aarF domain-containing protein kinase 5 - Homo sapiens (Human) - ADCK5 gene The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr). Taurus_UMD|evm.model.AC_000171.1.40 Q863Y7 S52A2_PIG 85.507 0.919822 1.00673 SLC52A2 - Solute carrier family 52, riboflavin transporter, member 2 - Sus scrofa (Pig) - SLC52A2 gene Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. May also act as a receptor for 4-hydroxybutyrate. Taurus_UMD|evm.model.AC_000171.1.41 Q8N531 FBXL6_HUMAN 84.586 0.942056 0.992579 FBXL6 - F-box/LRR-repeat protein 6 - Homo sapiens (Human) - FBXL6 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000171.1.42 Q2WGJ8 TM249_HUMAN 84.242 0.849741 0.821277 TMEM249 - Transmembrane protein 249 - Homo sapiens (Human) - TMEM249 gene Taurus_UMD|evm.model.AC_000171.1.43 Q9NQ03 SCRT2_HUMAN 91.111 0.379603 1.14984 SCRT2 - Transcriptional repressor scratch 2 - Homo sapiens (Human) - SCRT2 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000171.1.45 Q8MK44 DGAT1_BOVIN 96.728 0.995789 0.97137 DGAT1 - Diacylglycerol O-acyltransferase 1 - Bos taurus (Bovine) - DGAT1 gene Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:18704537). Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats. In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (By similarity). Also present in female mammary glands, where it produces fat in the milk (PubMed:18704537, PubMed:15342525). May be involved in VLDL (very low density lipoprotein) assembly (By similarity). In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (By similarity). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). Taurus_UMD|evm.model.AC_000171.1.46 Q08DJ8 HSF1_BOVIN 94.756 0.99639 1.05524 HSF1 - Heat shock factor protein 1 - Bos taurus (Bovine) - HSF1 gene Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes. Activation is reversible, and during the attenuation and recovery phase period of the heat shock response, returns to its unactivated form. Binds to inverted 5'-NGAAN-3' pentamer DNA sequences. Binds to chromatin at heat shock gene promoters. Plays also several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells. Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner. Plays a role in nuclear export of stress-induced HSP70 mRNA. Plays a role in the regulation of mitotic progression. Plays also a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner. Involved in stress-induced cancer cell proliferation in a IER5-dependent manner. Taurus_UMD|evm.model.AC_000171.1.47 Q14137 BOP1_HUMAN 84.400 0.997308 0.995979 BOP1 - Ribosome biogenesis protein BOP1 - Homo sapiens (Human) - BOP1 gene Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Taurus_UMD|evm.model.AC_000171.1.48 A7E2Y6 MROH1_BOVIN 99.153 0.957895 1.03511 MROH1 - Maestro heat-like repeat-containing protein family member 1 - Bos taurus (Bovine) - MROH1 gene Taurus_UMD|evm.model.AC_000171.1.49 Q8C1R0 TSSK5_MOUSE 76.106 0.800948 1.13441 Tssk5 - Testis-specific serine/threonine-protein kinase 5 - Mus musculus (Mouse) - Tssk5 gene May be involved in a signaling pathway during male germ cell development or mature sperm function. Taurus_UMD|evm.model.AC_000171.1.50 Q9BTY7 HGH1_HUMAN 84.777 0.984456 0.989744 HGH1 - Protein HGH1 homolog - Homo sapiens (Human) - HGH1 gene Taurus_UMD|evm.model.AC_000171.1.51 A6NE52 WDR97_HUMAN 72.386 0.246011 0.92725 WDR97 - WD repeat-containing protein 97 - Homo sapiens (Human) - WDR97 gene Taurus_UMD|evm.model.AC_000171.1.52 A5D9C6 MAF1_BOVIN 100.000 0.992337 1.00385 MAF1 - Repressor of RNA polymerase III transcription MAF1 homolog - Bos taurus (Bovine) - MAF1 gene Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (By similarity). Plays also a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB. When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout. Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (By similarity). Taurus_UMD|evm.model.AC_000171.1.54 E1BDF2 SHRPN_BOVIN 100.000 0.995122 1.00244 SHARPIN - Sharpin - Bos taurus (Bovine) - SHARPIN gene Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Taurus_UMD|evm.model.AC_000171.1.55 P00125 CY1_BOVIN 100.000 0.993865 1.00308 CYC1 - Cytochrome c1, heme protein, mitochondrial precursor - Bos taurus (Bovine) - CYC1 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c. Taurus_UMD|evm.model.AC_000171.1.56 O43292 GPAA1_HUMAN 91.626 0.996759 0.993559 GPAA1 - Glycosylphosphatidylinositol anchor attachment 1 protein - Homo sapiens (Human) - GPAA1 gene Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. Taurus_UMD|evm.model.AC_000171.1.57 Q7YRA3 EXOS4_BOVIN 100.000 0.99187 1.00408 EXOSC4 - Exosome complex component RRP41 - Bos taurus (Bovine) - EXOSC4 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs (By similarity). Taurus_UMD|evm.model.AC_000171.1.58 Q75WB5 OPLA_BOVIN 99.379 0.929242 1.07531 OPLAH - 5-oxoprolinase - Bos taurus (Bovine) - OPLAH gene Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Taurus_UMD|evm.model.AC_000171.1.59 D6MZJ6 NSMA5_MOUSE 68.094 0.983122 0.981366 Smpd5 - Sphingomyelin phosphodiesterase 5 - Mus musculus (Mouse) - Smpd5 gene Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. Taurus_UMD|evm.model.AC_000171.1.60 Q148B6 SPERI_MOUSE 84.615 0.315447 1.28125 Spatc1 - Speriolin - Mus musculus (Mouse) - Spatc1 gene centrosome, cytoplasm, gamma-tubulin binding Taurus_UMD|evm.model.AC_000171.1.61 Q32L53 LFG1_BOVIN 100.000 0.933504 1.06831 GRINA - Protein lifeguard 1 - Bos taurus (Bovine) - GRINA gene Potential apoptotic regulator. Taurus_UMD|evm.model.AC_000171.1.62 Q53GL7 PAR10_HUMAN 65.982 0.992693 0.934634 PARP10 - Protein mono-ADP-ribosyltransferase PARP10 - Homo sapiens (Human) - PARP10 gene ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737). Taurus_UMD|evm.model.AC_000171.1.63 Q15149 PLEC_HUMAN 91.885 0.983657 0.966695 PLEC - Plectin - Homo sapiens (Human) - PLEC gene Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. Taurus_UMD|evm.model.AC_000171.1.64 P58107 EPIPL_HUMAN 79.068 0.4101 0.708333 EPPK1 - Epiplakin - Homo sapiens (Human) - EPPK1 gene Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:15671067, PubMed:27206504, PubMed:23398049). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:27206504, PubMed:23398049). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization (By similarity). Taurus_UMD|evm.model.AC_000171.1.65 P58107 EPIPL_HUMAN 85.612 0.995169 0.162736 EPPK1 - Epiplakin - Homo sapiens (Human) - EPPK1 gene Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:15671067, PubMed:27206504, PubMed:23398049). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:27206504, PubMed:23398049). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization (By similarity). Taurus_UMD|evm.model.AC_000171.1.66 Q91V36 NRBP2_MOUSE 94.318 0.739057 1.19038 Nrbp2 - Nuclear receptor-binding protein 2 - Mus musculus (Mouse) - Nrbp2 gene May regulate apoptosis of neural progenitor cells during their differentiation. Taurus_UMD|evm.model.AC_000171.1.67 Q2HJG2 PUF60_BOVIN 99.808 0.9254 1.06226 PUF60 - Poly(U)-binding-splicing factor PUF60 - Bos taurus (Bovine) - PUF60 gene DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA (By similarity). Taurus_UMD|evm.model.AC_000171.1.68 Q80U72 SCRIB_MOUSE 82.564 0.998744 0.987593 Scrib - Protein scribble homolog - Mus musculus (Mouse) - Scrib gene Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:12499390, PubMed:18716323, PubMed:19041750, PubMed:18329370). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (PubMed:18329370). Most probably functions in the establishment of apico-basal cell polarity (PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:19041750). May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling (PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:19458197). Functions as an activator of Rac GTPase activity. Taurus_UMD|evm.model.AC_000171.1.69 Q3TYL0 IQAK1_MOUSE 74.560 0.927273 1.01852 Iqank1 - IQ motif and ankyrin repeat domain-containing protein 1 - Mus musculus (Mouse) - Iqank1 gene Taurus_UMD|evm.model.AC_000171.1.70 Q6ZRV2 FA83H_HUMAN 85.823 0.859432 1.16455 FAM83H - Protein FAM83H - Homo sapiens (Human) - FAM83H gene May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). Taurus_UMD|evm.model.AC_000171.1.71 Q8TD08 MK15_HUMAN 71.676 0.965844 0.96875 MAPK15 - Mitogen-activated protein kinase 15 - Homo sapiens (Human) - MAPK15 gene Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:22948227, PubMed:24618899, PubMed:29021280, PubMed:21847093, PubMed:20733054). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:20638370, PubMed:19166846). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). Taurus_UMD|evm.model.AC_000171.1.72 O75123 ZN623_HUMAN 81.136 0.991919 0.923507 ZNF623 - Zinc finger protein 623 - Homo sapiens (Human) - ZNF623 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000171.1.73 A3KN32 ZNF34_BOVIN 51.799 0.408284 0.622468 ZNF34 - Zinc finger protein 34 - Bos taurus (Bovine) - ZNF34 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000171.1.74 Q8K3X2 FCL_CRIGR 93.458 0.76555 1.30218 GFUS - GDP-L-fucose synthase - Cricetulus griseus (Chinese hamster) - GFUS gene Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. Taurus_UMD|evm.model.AC_000171.1.75 Q58D08 P5CR3_BOVIN 100.000 0.993528 1.00325 PYCR3 - Pyrroline-5-carboxylate reductase 3 - Bos taurus (Bovine) - PYCR3 gene Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. Taurus_UMD|evm.model.AC_000171.1.76 G3MY25 TIGD5_BOVIN 100.000 0.996894 1.00156 TIGD5 - Tigger transposable element-derived protein 5 - Bos taurus (Bovine) - TIGD5 gene nucleus, DNA binding Taurus_UMD|evm.model.AC_000171.1.77 A5D989 EF1D_BOVIN 100.000 0.422727 2.35714 EEF1D - Elongation factor 1-delta - Bos taurus (Bovine) - EEF1D gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Taurus_UMD|evm.model.AC_000171.1.78 A5PK51 PNCB_BOVIN 99.628 0.996289 1.00186 NAPRT - Nicotinate phosphoribosyltransferase - Bos taurus (Bovine) - NAPRT gene Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis. Taurus_UMD|evm.model.AC_000171.1.79 A6NGR9 MROH6_HUMAN 80.690 0.995787 0.990264 MROH6 - Maestro heat-like repeat-containing protein family member 6 - Homo sapiens (Human) - MROH6 gene Taurus_UMD|evm.model.AC_000171.1.80 P57764 GSDMD_HUMAN 64.330 0.991786 1.0062 GSDMD - Gasdermin-D - Homo sapiens (Human) - GSDMD gene Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27281216). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:26375259, PubMed:27281216). Taurus_UMD|evm.model.AC_000171.1.81 Q8IXZ2 ZC3H3_HUMAN 70.951 0.434416 0.876582 ZC3H3 - Zinc finger CCCH domain-containing protein 3 - Homo sapiens (Human) - ZC3H3 gene Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity). Taurus_UMD|evm.model.AC_000171.1.82 Q8NHW3 MAFA_HUMAN 88.102 0.994318 0.997167 MAFA - Transcription factor MafA - Homo sapiens (Human) - MAFA gene Transcription factor that activates insulin gene expression (PubMed:15993959, PubMed:12011435). Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959). Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498). Taurus_UMD|evm.model.AC_000171.1.84 Q8TCX5 RHPN1_HUMAN 73.534 0.99697 0.985075 RHPN1 - Rhophilin-1 - Homo sapiens (Human) - RHPN1 gene Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules. Taurus_UMD|evm.model.AC_000171.1.85 Q969P6 TOP1M_HUMAN 68.293 0.144144 0.923461 TOP1MT - DNA topoisomerase I, mitochondrial precursor - Homo sapiens (Human) - TOP1MT gene Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Taurus_UMD|evm.model.AC_000171.1.86 Q9H7X3 ZN696_HUMAN 64.921 0.589984 1.70856 ZNF696 - Zinc finger protein 696 - Homo sapiens (Human) - ZNF696 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000171.1.87 P10075 GLI4_HUMAN 76.923 0.625608 1.64096 GLI4 - Zinc finger protein GLI4 - Homo sapiens (Human) - GLI4 gene DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription, DNA-templated Taurus_UMD|evm.model.AC_000171.1.88 Q9D1N2 HDBP1_MOUSE 54.861 0.80814 0.754386 Gpihbp1 - Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 precursor - Mus musculus (Mouse) - Gpihbp1 gene Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries (PubMed:20620994). Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries (PubMed:20620994, PubMed:24726386, PubMed:27811232). Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis (PubMed:17403372). Binds chylomicrons and phospholipid particles that contain APOA5 (PubMed:18340083). Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL (PubMed:12496272). Taurus_UMD|evm.model.AC_000171.1.89 A0JNB3 LY6H_BOVIN 99.286 0.985816 1.00714 LY6H - Lymphocyte antigen 6H precursor - Bos taurus (Bovine) - LY6H gene plasma membrane, acetylcholine receptor binding, acetylcholine receptor inhibitor activity, acetylcholine receptor signaling pathway Taurus_UMD|evm.model.AC_000171.1.90 H3BQJ8 LY6L_HUMAN 52.137 0.834532 1.00725 LY6L - Lymphocyte antigen 6L precursor - Homo sapiens (Human) - LY6L gene plasma membrane Taurus_UMD|evm.model.AC_000171.1.91 Q16553 LY6E_HUMAN 70.229 0.984733 1 LY6E - Lymphocyte antigen 6E precursor - Homo sapiens (Human) - LY6E gene GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (By similarity). Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion (PubMed:32641482). Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (By similarity). Taurus_UMD|evm.model.AC_000171.1.93 P15150 C11B1_BOVIN 93.638 0.995951 0.982107 CYP11B1 - Cytochrome P450 11B1, mitochondrial precursor - Bos taurus (Bovine) - CYP11B1 gene A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Taurus_UMD|evm.model.AC_000171.1.94 Q17RY6 LY6K_HUMAN 39.655 0.656051 0.951515 LY6K - Lymphocyte antigen 6K precursor - Homo sapiens (Human) - LY6K gene Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth (PubMed:18089789). Taurus_UMD|evm.model.AC_000171.1.95 P15150 C11B1_BOVIN 95.464 0.995556 0.894632 CYP11B1 - Cytochrome P450 11B1, mitochondrial precursor - Bos taurus (Bovine) - CYP11B1 gene A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Taurus_UMD|evm.model.AC_000171.1.96 Q90986 LY6E_CHICK 26.230 0.9375 0.888889 LY6E - Lymphocyte antigen 6E precursor - Gallus gallus (Chicken) - LY6E gene anchored component of membrane, cell surface, plasma membrane, acetylcholine receptor inhibitor activity, lymphoid progenitor cell differentiation Taurus_UMD|evm.model.AC_000171.1.98 Q148C3 LY6D_BOVIN 100.000 0.984496 1.00781 LY6D - Lymphocyte antigen 6D precursor - Bos taurus (Bovine) - LY6D gene May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification (By similarity). Taurus_UMD|evm.model.AC_000171.1.99 Q1RMQ4 LYNX1_BOVIN 100.000 0.982906 1.00862 LYNX1 - Ly-6/neurotoxin-like protein 1 precursor - Bos taurus (Bovine) - LYNX1 gene Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR. In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs. Prevents plasticity in the primary visual cortex late in life. Taurus_UMD|evm.model.AC_000171.1.100 Q6UXB3 LYPD2_HUMAN 79.439 0.821705 1.032 LYPD2 - Ly6/PLAUR domain-containing protein 2 precursor - Homo sapiens (Human) - LYPD2 gene extracellular region, plasma membrane Taurus_UMD|evm.model.AC_000171.1.101 P55000 SLUR1_HUMAN 65.306 0.76378 1.23301 SLURP1 - Secreted Ly-6/uPAR-related protein 1 precursor - Homo sapiens (Human) - SLURP1 gene Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have an immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896). Taurus_UMD|evm.model.AC_000171.1.102 A6H707 THEM6_BOVIN 100.000 0.799228 1.24519 THEM6 - Protein THEM6 precursor - Bos taurus (Bovine) - THEM6 gene Taurus_UMD|evm.model.AC_000171.1.103 O43653 PSCA_HUMAN 56.818 0.669565 1.00877 PSCA - Prostate stem cell antigen precursor - Homo sapiens (Human) - PSCA gene May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. Taurus_UMD|evm.model.AC_000171.1.104 O75564 JERKY_HUMAN 70.433 0.928166 0.951439 JRK - Jerky protein homolog - Homo sapiens (Human) - JRK gene May bind DNA. Taurus_UMD|evm.model.AC_000171.1.106 Q7LC44 ARC_HUMAN 91.667 0.994962 1.00253 ARC - Activity-regulated cytoskeleton-associated protein - Homo sapiens (Human) - ARC gene Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (By similarity). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity). Taurus_UMD|evm.model.AC_000171.1.107 Q6ZUA9 MROH5_HUMAN 35.847 0.884259 0.819423 MROH5 - Maestro heat-like repeat family member 5 - Homo sapiens (Human) - MROH5 gene Taurus_UMD|evm.model.AC_000171.1.109 O14514 AGRB1_HUMAN 92.434 0.998732 0.995581 ADGRB1 - Adhesion G protein-coupled receptor B1 precursor - Homo sapiens (Human) - ADGRB1 gene Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720). Taurus_UMD|evm.model.AC_000171.1.113 Q96NA8 TSNA1_HUMAN 77.432 0.995976 0.968811 TSNARE1 - t-SNARE domain-containing protein 1 - Homo sapiens (Human) - TSNARE1 gene endomembrane system, integral component of membrane, SNARE complex, SNAP receptor activity, SNARE binding, intracellular protein transport, vesicle docking, vesicle fusion Taurus_UMD|evm.model.AC_000171.1.117 Q6ZUA9 MROH5_HUMAN 76.923 0.708333 0.0546282 MROH5 - Maestro heat-like repeat family member 5 - Homo sapiens (Human) - MROH5 gene Taurus_UMD|evm.model.AC_000171.1.118 Q6ZUA9 MROH5_HUMAN 73.556 0.798526 0.308801 MROH5 - Maestro heat-like repeat family member 5 - Homo sapiens (Human) - MROH5 gene Taurus_UMD|evm.model.AC_000171.1.119 A2VDT1 TP4A3_BOVIN 100.000 0.988506 1.00578 PTP4A3 - Protein tyrosine phosphatase type IVA 3 precursor - Bos taurus (Bovine) - PTP4A3 gene Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II (By similarity). Taurus_UMD|evm.model.AC_000171.1.122 Q99678 GPR20_HUMAN 83.934 0.994475 1.01117 GPR20 - G-protein coupled receptor 20 - Homo sapiens (Human) - GPR20 gene Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP. Taurus_UMD|evm.model.AC_000171.1.124 Q5BKX6 S45A4_HUMAN 82.398 0.997416 1.00781 SLC45A4 - Solute carrier family 45 member 4 - Homo sapiens (Human) - SLC45A4 gene membrane, sucrose:proton symporter activity, sucrose transport Taurus_UMD|evm.model.AC_000171.1.125 A2RUS2 DEND3_HUMAN 79.651 0.935787 1.06594 DENND3 - DENN domain-containing protein 3 - Homo sapiens (Human) - DENND3 gene Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity). Taurus_UMD|evm.model.AC_000171.1.126 Q05397 FAK1_HUMAN 92.490 0.849535 1.12452 PTK2 - Focal adhesion kinase 1 - Homo sapiens (Human) - PTK2 gene Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. Taurus_UMD|evm.model.AC_000171.1.127 Q6QME8 AGO2_BOVIN 99.884 0.997677 1.00116 AGO2 - Protein argonaute-2 - Bos taurus (Bovine) - AGO2 gene Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. Taurus_UMD|evm.model.AC_000171.1.128 Q9JKP8 CHRC1_MOUSE 90.991 0.839695 1.0155 Chrac1 - Chromatin accessibility complex protein 1 - Mus musculus (Mouse) - Chrac1 gene Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Taurus_UMD|evm.model.AC_000171.1.129 Q32PH0 TPPC9_BOVIN 94.906 0.94301 0.986819 TRAPPC9 - Trafficking protein particle complex subunit 9 - Bos taurus (Bovine) - TRAPPC9 gene Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi. Taurus_UMD|evm.model.AC_000171.1.131 Q9NPC2 KCNK9_HUMAN 97.938 0.396694 0.647059 KCNK9 - Potassium channel subfamily K member 9 - Homo sapiens (Human) - KCNK9 gene pH-dependent, voltage-insensitive, background potassium channel protein. Taurus_UMD|evm.model.AC_000171.1.132 Q9NPC2 KCNK9_HUMAN 91.096 0.583166 1.33422 KCNK9 - Potassium channel subfamily K member 9 - Homo sapiens (Human) - KCNK9 gene pH-dependent, voltage-insensitive, background potassium channel protein. Taurus_UMD|evm.model.AC_000171.1.134 Q8NFW1 COMA1_HUMAN 82.975 0.992935 0.957565 COL22A1 - Collagen alpha-1(XXII) chain precursor - Homo sapiens (Human) - COL22A1 gene Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts. Taurus_UMD|evm.model.AC_000171.1.137 Q641I1 F135B_XENLA 83.896 0.27331 1.02108 fam135b - Protein FAM135B - Xenopus laevis (African clawed frog) - fam135b gene Taurus_UMD|evm.model.AC_000171.1.140 O75525 KHDR3_HUMAN 97.688 0.994236 1.00289 KHDRBS3 - KH domain-containing, RNA-binding, signal transduction-associated protein 3 - Homo sapiens (Human) - KHDRBS3 gene RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Taurus_UMD|evm.model.AC_000171.1.141 Q9P243 ZFAT_HUMAN 85.325 0.95814 1.03781 ZFAT - Zinc finger protein ZFAT - Homo sapiens (Human) - ZFAT gene May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). Taurus_UMD|evm.model.AC_000171.1.142 Q02745 SIA4A_PIG 89.538 0.952941 0.991254 ST3GAL1 - CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 - Sus scrofa (Pig) - ST3GAL1 gene A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:19820709, PubMed:8288606). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:19820709, PubMed:8288606). Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans (PubMed:19820709, PubMed:8288606). As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response (By similarity). Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser (PubMed:8288606). Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8288606) (By similarity). Taurus_UMD|evm.model.AC_000171.1.143 Q3SYX0 NDRG1_BOVIN 99.740 0.994805 1.0026 NDRG1 - Protein NDRG1 - Bos taurus (Bovine) - NDRG1 gene Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy (By similarity). Taurus_UMD|evm.model.AC_000171.1.144 O95388 CCN4_HUMAN 85.879 0.802784 1.17439 CCN4 - CCN family member 4 precursor - Homo sapiens (Human) - CCN4 gene Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. Taurus_UMD|evm.model.AC_000171.1.145 P01267 THYG_BOVIN 100.000 0.425197 0.0917299 TG - Thyroglobulin precursor - Bos taurus (Bovine) - TG gene Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). One dimer produces 7 thyroid hormone molecules (By similarity). Taurus_UMD|evm.model.AC_000171.1.146 P01267 THYG_BOVIN 99.324 0.794595 0.0668111 TG - Thyroglobulin precursor - Bos taurus (Bovine) - TG gene Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). One dimer produces 7 thyroid hormone molecules (By similarity). Taurus_UMD|evm.model.AC_000171.1.147 P01267 THYG_BOVIN 99.524 0.933036 0.0808956 TG - Thyroglobulin precursor - Bos taurus (Bovine) - TG gene Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). One dimer produces 7 thyroid hormone molecules (By similarity). Taurus_UMD|evm.model.AC_000171.1.148 Q13239 SLAP1_HUMAN 91.304 0.870253 1.14493 SLA - Src-like-adapter - Homo sapiens (Human) - SLA gene Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Taurus_UMD|evm.model.AC_000171.1.149 P01267 THYG_BOVIN 97.835 0.99588 0.87649 TG - Thyroglobulin precursor - Bos taurus (Bovine) - TG gene Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). One dimer produces 7 thyroid hormone molecules (By similarity). Taurus_UMD|evm.model.AC_000171.1.150 A8MW92 P20L1_HUMAN 91.078 0.997984 0.975418 PHF20L1 - PHD finger protein 20-like protein 1 - Homo sapiens (Human) - PHF20L1 gene NSL complex, histone acetylation, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000171.1.151 Q6P5X7 TMM71_HUMAN 69.799 0.993289 1.01017 TMEM71 - Transmembrane protein 71 - Homo sapiens (Human) - TMEM71 gene mitochondrion Taurus_UMD|evm.model.AC_000171.1.152 Q1RMR5 TILB_BOVIN 99.789 0.995781 1.00424 DNAAF11 - Dynein axonemal assembly factor 11 - Bos taurus (Bovine) - DNAAF11 gene Involved in dynein arm assembly, is important for expression and transporting outer dynein arm (ODA) proteins from the cytoplasm to the cilia. Acts as a crucial component in the formation and motility of spermatozoal flagella. Taurus_UMD|evm.model.AC_000171.1.153 P58126 KCNQ3_BOVIN 100.000 0.984615 0.150115 KCNQ3 - Potassium voltage-gated channel subfamily KQT member 3 - Bos taurus (Bovine) - KCNQ3 gene Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. Taurus_UMD|evm.model.AC_000171.1.155 P58126 KCNQ3_BOVIN 99.865 0.981383 0.86836 KCNQ3 - Potassium voltage-gated channel subfamily KQT member 3 - Bos taurus (Bovine) - KCNQ3 gene Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. Taurus_UMD|evm.model.AC_000171.1.156 C9JL84 HHLA1_HUMAN 70.556 0.996296 1.01695 HHLA1 - HERV-H LTR-associating protein 1 precursor - Homo sapiens (Human) - HHLA1 gene Taurus_UMD|evm.model.AC_000171.1.157 Q02509 OC90_HUMAN 70.732 0.991837 1.02725 OC90 - Otoconin-90 precursor - Homo sapiens (Human) - OC90 gene Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OTOL1, modulates calcite crystal morphology and growth kinetics. It is unlikely that this protein has phospholipase A2 activity. Taurus_UMD|evm.model.AC_000171.1.158 Q14156 EFR3A_HUMAN 97.143 0.102564 1.23508 EFR3A - Protein EFR3 homolog A - Homo sapiens (Human) - EFR3A gene Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). Taurus_UMD|evm.model.AC_000171.1.159 Q3T160 NPM_BOVIN 80.417 0.946502 0.826531 NPM1 - Nucleophosmin - Bos taurus (Bovine) - NPM1 gene Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. Taurus_UMD|evm.model.AC_000171.1.160 P40145 ADCY8_HUMAN 97.526 0.812459 1.23181 ADCY8 - Adenylate cyclase type 8 - Homo sapiens (Human) - ADCY8 gene Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells. Taurus_UMD|evm.model.AC_000171.1.161 Q6Q311 RS25_SHEEP 86.076 0.795918 0.784 RPS25 - 40S ribosomal protein S25 - Ovis aries (Sheep) - RPS25 gene Taurus_UMD|evm.model.AC_000171.1.163 O97902 ASAP1_BOVIN 97.431 0.998185 0.976085 ASAP1 - Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 - Bos taurus (Bovine) - ASAP1 gene Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. Plays a role in ciliogenesis (By similarity). May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Taurus_UMD|evm.model.AC_000171.1.164 Q9NUQ9 CYRIB_HUMAN 99.668 0.906344 1.0216 CYRIB - CYFIP-related Rac1 interactor B - Homo sapiens (Human) - CYRIB gene Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585, PubMed:30250061). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (PubMed:30250061). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585). Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity). Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164). Taurus_UMD|evm.model.AC_000171.1.165 Q9BYG8 GSDMC_HUMAN 46.154 0.295019 0.51378 GSDMC - Gasdermin-C - Homo sapiens (Human) - GSDMC gene This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death. Taurus_UMD|evm.model.AC_000171.1.166 Q9BYG8 GSDMC_HUMAN 52.148 0.922201 1.0374 GSDMC - Gasdermin-C - Homo sapiens (Human) - GSDMC gene This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death. Taurus_UMD|evm.model.AC_000171.1.172 Q2HJ27 MYC_BOVIN 100.000 0.995455 1.00228 MYC - Myc proto-oncogene protein - Bos taurus (Bovine) - MYC gene Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Taurus_UMD|evm.model.AC_000171.1.175 Q8VHF0 MARK3_RAT 50.633 0.804348 0.115433 Mark3 - MAP/microtubule affinity-regulating kinase 3 - Rattus norvegicus (Rat) - Mark3 gene Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAPT/TAU, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Taurus_UMD|evm.model.AC_000171.1.176 Q05512 MARK2_MOUSE 43.038 0.300905 0.569588 Mark2 - Serine/threonine-protein kinase MARK2 - Mus musculus (Mouse) - Mark2 gene Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. Taurus_UMD|evm.model.AC_000171.1.179 Q03141 MARK3_MOUSE 56.870 0.825949 0.419655 Mark3 - MAP/microtubule affinity-regulating kinase 3 - Mus musculus (Mouse) - Mark3 gene Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAPT/TAU, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Taurus_UMD|evm.model.AC_000171.1.180 O08679 MARK2_RAT 62.500 0.0624013 1.75346 Mark2 - Serine/threonine-protein kinase MARK2 - Rattus norvegicus (Rat) - Mark2 gene Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. Taurus_UMD|evm.model.AC_000171.1.181 Q8VHJ5 MARK1_MOUSE 31.667 0.215873 0.396226 Mark1 - Serine/threonine-protein kinase MARK1 - Mus musculus (Mouse) - Mark1 gene Serine/threonine-protein kinase (By similarity). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Taurus_UMD|evm.model.AC_000171.1.183 Q96L34 MARK4_HUMAN 56.790 0.190476 0.558511 MARK4 - MAP/microtubule affinity-regulating kinase 4 - Homo sapiens (Human) - MARK4 gene Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Taurus_UMD|evm.model.AC_000171.1.184 Q9P0L2 MARK1_HUMAN 38.333 0.833333 0.135849 MARK1 - Serine/threonine-protein kinase MARK1 - Homo sapiens (Human) - MARK1 gene Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Taurus_UMD|evm.model.AC_000171.1.185 Q8VHJ5 MARK1_MOUSE 59.603 0.761421 0.247799 Mark1 - Serine/threonine-protein kinase MARK1 - Mus musculus (Mouse) - Mark1 gene Serine/threonine-protein kinase (By similarity). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Taurus_UMD|evm.model.AC_000171.1.186 O08679 MARK2_RAT 54.098 0.870206 0.469529 Mark2 - Serine/threonine-protein kinase MARK2 - Rattus norvegicus (Rat) - Mark2 gene Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. Taurus_UMD|evm.model.AC_000171.1.188 Q7KZI7 MARK2_HUMAN 43.709 0.26643 0.714467 MARK2 - Serine/threonine-protein kinase MARK2 - Homo sapiens (Human) - MARK2 gene Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. Taurus_UMD|evm.model.AC_000171.1.189 O08678 MARK1_RAT 55.357 0.516279 0.271122 Mark1 - Serine/threonine-protein kinase MARK1 - Rattus norvegicus (Rat) - Mark1 gene Serine/threonine-protein kinase (By similarity). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (PubMed:14517247, PubMed:14741102, PubMed:9108484). Taurus_UMD|evm.model.AC_000171.1.191 Q96KN1 LRAT2_HUMAN 88.818 0.993631 1.0129 LRATD2 - Protein LRATD2 - Homo sapiens (Human) - LRATD2 gene cytoplasm, plasma membrane Taurus_UMD|evm.model.AC_000171.1.193 Q5E995 RS6_BOVIN 80.952 0.992248 0.518072 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Taurus_UMD|evm.model.AC_000171.1.194 Q96RU8 TRIB1_HUMAN 96.774 0.994638 1.00269 TRIB1 - Tribbles homolog 1 - Homo sapiens (Human) - TRIB1 gene Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797). Taurus_UMD|evm.model.AC_000171.1.195 Q32KY9 NSE2_BOVIN 99.597 0.991968 1.00403 NSMCE2 - E3 SUMO-protein ligase NSE2 - Bos taurus (Bovine) - NSMCE2 gene E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression. Taurus_UMD|evm.model.AC_000171.1.197 Q12768 WASC5_HUMAN 97.929 0.998276 1.00086 WASHC5 - WASH complex subunit 5 - Homo sapiens (Human) - WASHC5 gene Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). May be involved in axonal outgrowth. Involved in cellular localization of ADRB2 (PubMed:23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed:23676666). Taurus_UMD|evm.model.AC_000171.1.198 Q14534 ERG1_HUMAN 87.631 0.99651 0.998258 SQLE - Squalene monooxygenase - Homo sapiens (Human) - SQLE gene Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. Taurus_UMD|evm.model.AC_000171.1.199 Q32KN0 ZN572_BOVIN 99.811 0.996226 1.00189 ZNF572 - Zinc finger protein 572 - Bos taurus (Bovine) - ZNF572 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000171.1.200 O43312 MTSS1_HUMAN 97.098 0.997365 1.0053 MTSS1 - Protein MTSS 1 - Homo sapiens (Human) - MTSS1 gene May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. Taurus_UMD|evm.model.AC_000171.1.201 Q02369 NDUB9_BOVIN 100.000 0.988889 1.00559 NDUFB9 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 - Bos taurus (Bovine) - NDUFB9 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000171.1.202 Q148G4 TATD1_BOVIN 100.000 0.993289 1.00337 TATDN1 - Putative deoxyribonuclease TATDN1 - Bos taurus (Bovine) - TATDN1 gene Putative deoxyribonuclease. Taurus_UMD|evm.model.AC_000171.1.203 Q5RBT7 RN139_PONAB 95.789 0.996997 1.00301 RNF139 - E3 ubiquitin-protein ligase RNF139 - Pongo abelii (Sumatran orangutan) - RNF139 gene E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Involved in the sterol-accelerated degradation of HMGCR. This is achieved through binding to INSIG1 and/or INSIG2 at the ER membrane. In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. Taurus_UMD|evm.model.AC_000171.1.204 Q58D65 TYW2_BOVIN 99.315 0.912317 1.09361 TRMT12 - tRNA wybutosine-synthesizing protein 2 homolog - Bos taurus (Bovine) - TRMT12 gene S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity). Taurus_UMD|evm.model.AC_000171.1.205 Q0VCH8 TMM65_BOVIN 93.644 0.990991 0.940678 TMEM65 - Transmembrane protein 65 precursor - Bos taurus (Bovine) - TMEM65 gene May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). Regulates mitochondrial respiration and mitochondrial DNA copy number maintenance (By similarity). Taurus_UMD|evm.model.AC_000171.1.207 Q2WGJ9 FR1L6_HUMAN 89.409 0.998925 1.00162 FER1L6 - Fer-1-like protein 6 - Homo sapiens (Human) - FER1L6 gene plasma membrane organization Taurus_UMD|evm.model.AC_000171.1.208 Q658Y4 F91A1_HUMAN 95.823 0.997616 1.00119 FAM91A1 - Protein FAM91A1 - Homo sapiens (Human) - FAM91A1 gene As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. Taurus_UMD|evm.model.AC_000171.1.209 Q29471 ANX13_CANLF 85.763 0.963934 0.96519 ANXA13 - Annexin A13 - Canis lupus familiaris (Dog) - ANXA13 gene Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup. Taurus_UMD|evm.model.AC_000171.1.210 Q2WGJ6 KLH38_HUMAN 86.082 0.947627 1.05164 KLHL38 - Kelch-like protein 38 - Homo sapiens (Human) - KLHL38 gene Taurus_UMD|evm.model.AC_000171.1.211 Q2M2U4 RNH2C_BOVIN 56.897 0.904762 0.763636 RNASEH2C - Ribonuclease H2 subunit C - Bos taurus (Bovine) - RNASEH2C gene Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity). Taurus_UMD|evm.model.AC_000171.1.212 Q2KHT6 FBX32_BOVIN 100.000 0.994382 1.00282 FBXO32 - F-box only protein 32 - Bos taurus (Bovine) - FBXO32 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity). Taurus_UMD|evm.model.AC_000171.1.213 Q3T0D3 NTAQ1_BOVIN 100.000 0.990385 1.00483 NTAQ1 - Protein N-terminal glutamine amidohydrolase - Bos taurus (Bovine) - NTAQ1 gene Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine. Taurus_UMD|evm.model.AC_000171.1.214 Q5RDX4 ATAD2_PONAB 95.146 0.0742358 1.2594 ATAD2 - ATPase family AAA domain-containing protein 2 - Pongo abelii (Sumatran orangutan) - ATAD2 gene May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation (By similarity). Taurus_UMD|evm.model.AC_000171.1.215 A2T7S4 ZHX1_PONPY 94.502 0.997712 1.00115 ZHX1 - Zinc fingers and homeoboxes protein 1 - Pongo pygmaeus (Bornean orangutan) - ZHX1 gene Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins (By similarity). Taurus_UMD|evm.model.AC_000171.1.216 Q96EF9 ZHX1R_HUMAN 85.305 0.725594 1.29795 ZHX1-C8orf76 - Zinc fingers and homeoboxes protein 1, isoform 2 - Homo sapiens (Human) - ZHX1-C8orf76 gene Taurus_UMD|evm.model.AC_000171.1.217 Q86UY5 FA83A_HUMAN 83.716 0.995413 1.00461 FAM83A - Protein FAM83A - Homo sapiens (Human) - FAM83A gene Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. Taurus_UMD|evm.model.AC_000171.1.218 Q29RL0 TBC31_BOVIN 100.000 0.99812 1.00094 TBC1D31 - TBC1 domain family member 31 - Bos taurus (Bovine) - TBC1D31 gene centrosome Taurus_UMD|evm.model.AC_000171.1.219 Q71SS4 DERL1_BOVIN 87.251 0.990909 0.876494 DERL1 - Derlin-1 - Bos taurus (Bovine) - DERL1 gene Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Taurus_UMD|evm.model.AC_000171.1.220 Q9Y6X8 ZHX2_HUMAN 91.169 0.997616 1.00239 ZHX2 - Zinc fingers and homeoboxes protein 2 - Homo sapiens (Human) - ZHX2 gene Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). Taurus_UMD|evm.model.AC_000171.1.222 Q17QF2 EFMT1_BOVIN 89.116 0.884848 0.730088 EEF1AKMT1 - EEF1A lysine methyltransferase 1 - Bos taurus (Bovine) - EEF1AKMT1 gene Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'. Taurus_UMD|evm.model.AC_000171.1.223 O97711 HYAS2_BOVIN 99.585 0.995859 0.875 HAS2 - Hyaluronan synthase 2 - Bos taurus (Bovine) - HAS2 gene Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity). Taurus_UMD|evm.model.AC_000171.1.224 O97711 HYAS2_BOVIN 82.779 0.983389 0.54529 HAS2 - Hyaluronan synthase 2 - Bos taurus (Bovine) - HAS2 gene Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity). Taurus_UMD|evm.model.AC_000171.1.225 P46089 GPR3_HUMAN 95.000 0.378641 0.312121 GPR3 - G-protein coupled receptor 3 - Homo sapiens (Human) - GPR3 gene Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity). Taurus_UMD|evm.model.AC_000171.1.226 P03709 FI_LAMBD 57.500 0.52 0.568182 Fi - DNA-packaging protein FI - Escherichia phage lambda - Fi gene Stimulates the interaction of procapsid with the terminase-DNA complex, thereby increasing the overall rate of DNA packaging. Before packaging, it likely coats the surface of the procapsid through binding mediated by c-terminal domain. FI presumably dissociates from the capsid once it inflates upon DNA packaging, and is not present in the mature virion. Taurus_UMD|evm.model.AC_000171.1.227 Q10126 YSM6_CAEEL 28.105 0.9 0.537634 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000171.1.228 A6H6T1 PRS40_MOUSE 45.172 0.746032 1.03562 Prss40 - Serine protease 40 precursor - Mus musculus (Mouse) - Prss40 gene May play an important role in the sperm/egg interaction; released during the acrosome reaction. Taurus_UMD|evm.model.AC_000171.1.229 Q7YRP3 VN1R3_PANTR 35.146 0.896154 0.83871 VN1R3 - Vomeronasal type-1 receptor 3 - Pan troglodytes (Chimpanzee) - VN1R3 gene Putative pheromone receptor. Taurus_UMD|evm.model.AC_000171.1.231 O02756 CEBPD_BOVIN 99.531 0.990654 0.835938 CEBPD - CCAAT/enhancer-binding protein delta - Bos taurus (Bovine) - CEBPD gene Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB. Taurus_UMD|evm.model.AC_000171.1.232 Q14159 SPIDR_HUMAN 62.094 0.997875 1.02842 SPIDR - DNA repair-scaffolding protein - Homo sapiens (Human) - SPIDR gene Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. Taurus_UMD|evm.model.AC_000171.1.233 A5PK61 H3C_BOVIN 100.000 0.985401 1.00735 H3-5 - Histone H3.3C - Bos taurus (Bovine) - H3-5 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000171.1.234 Q8WN22 PRKDC_CANLF 78.686 0.996848 0.995415 PRKDC - DNA-dependent protein kinase catalytic subunit - Canis lupus familiaris (Dog) - PRKDC gene Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (By similarity). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (By similarity). Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (By similarity). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity). Taurus_UMD|evm.model.AC_000171.1.235 P33991 MCM4_HUMAN 90.476 0.22252 0.432213 MCM4 - DNA replication licensing factor MCM4 - Homo sapiens (Human) - MCM4 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Taurus_UMD|evm.model.AC_000171.1.236 Q5R6C9 UB2V2_PONAB 100.000 0.676056 1.46897 UBE2V2 - Ubiquitin-conjugating enzyme E2 variant 2 - Pongo abelii (Sumatran orangutan) - UBE2V2 gene Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity). Taurus_UMD|evm.model.AC_000171.1.237 P33991 MCM4_HUMAN 97.917 0.56213 0.195829 MCM4 - DNA replication licensing factor MCM4 - Homo sapiens (Human) - MCM4 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Taurus_UMD|evm.model.AC_000171.1.239 Q32L26 EFCB1_BOVIN 100.000 0.99061 1.00472 EFCAB1 - EF-hand calcium-binding domain-containing protein 1 - Bos taurus (Bovine) - EFCAB1 gene Taurus_UMD|evm.model.AC_000171.1.242 Q3MHQ4 SNAI2_BOVIN 100.000 0.992565 1.00373 SNAI2 - Zinc finger protein SNAI2 - Bos taurus (Bovine) - SNAI2 gene Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity). Taurus_UMD|evm.model.AC_000171.1.243 A8E653 PDPFL_BOVIN 99.296 0.986014 1.01418 PPDPFL - Pancreatic progenitor cell differentiation and proliferation factor-like protein - Bos taurus (Bovine) - PPDPFL gene Taurus_UMD|evm.model.AC_000171.1.244 P15509 CSF2R_HUMAN 55.814 0.928571 0.805 CSF2RA - Granulocyte-macrophage colony-stimulating factor receptor subunit alpha precursor - Homo sapiens (Human) - CSF2RA gene Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Taurus_UMD|evm.model.AC_000171.1.245 Q9NSN8 SNTG1_HUMAN 72.289 0.831486 0.87234 SNTG1 - Gamma-1-syntrophin - Homo sapiens (Human) - SNTG1 gene Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation. Taurus_UMD|evm.model.AC_000171.1.247 Q5R7K4 PCMD2_PONAB 75.000 0.418919 0.204986 PCMTD2 - Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 - Pongo abelii (Sumatran orangutan) - PCMTD2 gene Taurus_UMD|evm.model.AC_000171.1.248 Q58CZ2 PCMD2_BOVIN 84.259 0.981651 0.301939 PCMTD2 - Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 - Bos taurus (Bovine) - PCMTD2 gene cytoplasm, protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Taurus_UMD|evm.model.AC_000171.1.250 A2VDP2 PCMD1_BOVIN 100.000 0.994398 1.00281 PCMTD1 - Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 - Bos taurus (Bovine) - PCMTD1 gene cytoplasm, protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Taurus_UMD|evm.model.AC_000171.1.252 O60284 ST18_HUMAN 85.375 0.958955 1.02388 ST18 - Suppression of tumorigenicity 18 protein - Homo sapiens (Human) - ST18 gene Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells. Taurus_UMD|evm.model.AC_000171.1.253 Q3T174 TAF12_BOVIN 96.000 0.772021 1.19876 TAF12 - Transcription initiation factor TFIID subunit 12 - Bos taurus (Bovine) - TAF12 gene TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription (By similarity). Taurus_UMD|evm.model.AC_000171.1.254 Q6UXT8 ALKL1_HUMAN 62.963 0.795455 0.682171 ALKAL1 - ALK and LTK ligand 1 precursor - Homo sapiens (Human) - ALKAL1 gene Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly. Taurus_UMD|evm.model.AC_000171.1.255 Q8TDY2 RBCC1_HUMAN 88.018 0.998742 0.997491 RB1CC1 - RB1-inducible coiled-coil protein 1 - Homo sapiens (Human) - RB1CC1 gene Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). Taurus_UMD|evm.model.AC_000171.1.256 Q8MJV3 NPBW1_BOVIN 99.396 0.993976 1.00302 NPBWR1 - Neuropeptides B/W receptor type 1 - Bos taurus (Bovine) - NPBWR1 gene Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity). Taurus_UMD|evm.model.AC_000171.1.257 Q2KIP6 OPRK_BOVIN 100.000 0.940447 1.06053 OPRK1 - Kappa-type opioid receptor - Bos taurus (Bovine) - OPRK1 gene G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions (By similarity). Taurus_UMD|evm.model.AC_000171.1.258 O46563 VATH_BOVIN 99.793 0.995868 1.00207 ATP6V1H - V-type proton ATPase subunit H - Bos taurus (Bovine) - ATP6V1H gene Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (By similarity). Taurus_UMD|evm.model.AC_000171.1.259 P79348 RGS20_BOVIN 95.708 0.493421 1.21925 RGS20 - Regulator of G-protein signaling 20 - Bos taurus (Bovine) - RGS20 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). Taurus_UMD|evm.model.AC_000171.1.260 Q29RL9 TCEA1_BOVIN 96.014 0.99278 0.920266 TCEA1 - Transcription elongation factor A protein 1 - Bos taurus (Bovine) - TCEA1 gene Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity). Taurus_UMD|evm.model.AC_000171.1.261 Q3MHR0 LYPA1_BOVIN 100.000 0.991342 1.00435 LYPLA1 - Acyl-protein thioesterase 1 - Bos taurus (Bovine) - LYPLA1 gene Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (By similarity). Has depalmitoylating activity toward KCNMA1 (By similarity). Could also depalmitoylate ADRB2 (By similarity). Acts as a lysophospholipase hydrolyzing various lysophospholipids including lysophosphatidylcholine (lyso-PC), lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity (By similarity). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (By similarity). Taurus_UMD|evm.model.AC_000171.1.262 Q0VC21 RM15_BOVIN 100.000 0.993289 1.00337 MRPL15 - 39S ribosomal protein L15, mitochondrial precursor - Bos taurus (Bovine) - MRPL15 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000171.1.263 Q9H6I2 SOX17_HUMAN 84.450 0.995134 0.992754 SOX17 - Transcription factor SOX-17 - Homo sapiens (Human) - SOX17 gene Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells. Taurus_UMD|evm.model.AC_000171.1.269 Q5GH76 XKR4_HUMAN 94.226 0.940415 0.593846 XKR4 - XK-related protein 4 - Homo sapiens (Human) - XKR4 gene membrane, plasma membrane, apoptotic process involved in development, engulfment of apoptotic cell, phosphatidylserine exposure on apoptotic cell surface Taurus_UMD|evm.model.AC_000171.1.270 Q0VCR6 TMM68_BOVIN 100.000 0.99403 1.00299 TMEM68 - Transmembrane protein 68 - Bos taurus (Bovine) - TMEM68 gene Taurus_UMD|evm.model.AC_000171.1.271 Q96RS0 TGS1_HUMAN 72.674 0.997664 1.00352 TGS1 - Trimethylguanosine synthase - Homo sapiens (Human) - TGS1 gene Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. Taurus_UMD|evm.model.AC_000171.1.272 P07948 LYN_HUMAN 96.875 0.996101 1.00195 LYN - Tyrosine-protein kinase Lyn - Homo sapiens (Human) - LYN gene Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Taurus_UMD|evm.model.AC_000171.1.273 P60868 RS20_RAT 100.000 0.983333 1.0084 Rps20 - 40S ribosomal protein S20 - Rattus norvegicus (Rat) - Rps20 gene cytosolic small ribosomal subunit, small ribosomal subunit, synapse, structural constituent of ribosome Taurus_UMD|evm.model.AC_000171.1.274 P50118 MOS_PIG 75.793 0.973607 0.988406 MOS - Proto-oncogene serine/threonine-protein kinase mos - Sus scrofa (Pig) - MOS gene cytoplasm, cytosol, MAP kinase kinase kinase activity, protein kinase activity, protein serine/threonine kinase activity, activation of MAPK activity, activation of MAPKK activity, chromatin organization, ERK1 and ERK2 cascade, establishment of meiotic spindle orientation Taurus_UMD|evm.model.AC_000171.1.275 Q6DJT9 PLAG1_HUMAN 96.400 0.996 1 PLAG1 - Zinc finger protein PLAG1 - Homo sapiens (Human) - PLAG1 gene Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia. Taurus_UMD|evm.model.AC_000171.1.278 Q17Q91 CHCH7_BOVIN 91.228 0.112224 5.87059 CHCHD7 - Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 - Bos taurus (Bovine) - CHCHD7 gene Taurus_UMD|evm.model.AC_000171.1.279 Q8N3Y7 RDHE2_HUMAN 78.571 0.977707 1.01618 SDR16C5 - Epidermal retinol dehydrogenase 2 - Homo sapiens (Human) - SDR16C5 gene Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH. Taurus_UMD|evm.model.AC_000171.1.280 A5PJJ7 S16C6_BOVIN 100.000 0.991803 0.772152 SDR16C6 - Short-chain dehydrogenase/reductase family 16C member 6 - Bos taurus (Bovine) - SDR16C6 gene lipid droplet, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Taurus_UMD|evm.model.AC_000171.1.281 P01211 PENK_BOVIN 100.000 0.992424 1.0038 PENK - Proenkephalin-A precursor - Bos taurus (Bovine) - PENK gene Enkelytin possesses antibacterial activity against Gram-positive bacteria such as Micrococcus luteus and Bacillus megaterium. Taurus_UMD|evm.model.AC_000171.1.282 Q2KJ53 IMPA3_BOVIN 100.000 0.99449 1.00276 BPNT2 - Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase - Bos taurus (Bovine) - BPNT2 gene Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4. Taurus_UMD|evm.model.AC_000171.1.284 Q2KJ38 F110B_BOVIN 99.259 0.300448 1.17368 FAM110B - Protein FAM110B - Bos taurus (Bovine) - FAM110B gene Taurus_UMD|evm.model.AC_000171.1.285 Q14CS0 UBX2B_HUMAN 90.332 0.993976 1.00302 UBXN2B - UBX domain-containing protein 2B - Homo sapiens (Human) - UBXN2B gene Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). Taurus_UMD|evm.model.AC_000171.1.286 O46491 CP7A1_PIG 88.600 0.994012 1 CYP7A1 - Cytochrome P450 7A1 - Sus scrofa (Pig) - CYP7A1 gene A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis. 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol. Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives. Taurus_UMD|evm.model.AC_000171.1.287 O00560 SDCB1_HUMAN 92.953 0.822715 1.21141 SDCBP - Syntenin-1 - Homo sapiens (Human) - SDCBP gene Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). Taurus_UMD|evm.model.AC_000171.1.288 Q92636 FAN_HUMAN 89.239 0.997828 1.00436 NSMAF - Protein FAN - Homo sapiens (Human) - NSMAF gene Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE. Taurus_UMD|evm.model.AC_000171.1.289 O94900 TOX_HUMAN 95.446 0.996212 1.0038 TOX - Thymocyte selection-associated high mobility group box protein TOX - Homo sapiens (Human) - TOX gene Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (By similarity). Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (By similarity). Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches. Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment. Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells. Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC) (By similarity). May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage. Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (PubMed:21126536) (By similarity). Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation-induced cell death (By similarity). Taurus_UMD|evm.model.AC_000171.1.290 P35219 CAH8_HUMAN 80.690 0.991597 0.82069 CA8 - Carbonic anhydrase-related protein - Homo sapiens (Human) - CA8 gene Does not have a carbonic anhydrase catalytic activity. Taurus_UMD|evm.model.AC_000171.1.291 Q3SYU2 EF2_BOVIN 77.301 0.234104 0.806527 EEF2 - Elongation factor 2 - Bos taurus (Bovine) - EEF2 gene Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). Taurus_UMD|evm.model.AC_000171.1.292 Q5R6B6 RAB2A_PONAB 88.679 0.989474 0.896226 RAB2A - Ras-related protein Rab-2A - Pongo abelii (Sumatran orangutan) - RAB2A gene Required for protein transport from the endoplasmic reticulum to the Golgi complex. Taurus_UMD|evm.model.AC_000171.1.294 Q9P2D1 CHD7_HUMAN 91.705 0.982468 0.951618 CHD7 - Chromodomain-helicase-DNA-binding protein 7 - Homo sapiens (Human) - CHD7 gene Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. Taurus_UMD|evm.model.AC_000171.1.297 Q8IUQ0 CLVS1_HUMAN 100.000 0.984733 0.370056 CLVS1 - Clavesin-1 - Homo sapiens (Human) - CLVS1 gene Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Taurus_UMD|evm.model.AC_000171.1.298 Q9D4C9 CLVS1_MOUSE 98.611 0.740933 0.545198 Clvs1 - Clavesin-1 - Mus musculus (Mouse) - Clvs1 gene Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Taurus_UMD|evm.model.AC_000171.1.300 Q28056 ASPH_BOVIN 98.305 0.997396 1.01857 ASPH - Aspartyl/asparaginyl beta-hydroxylase - Bos taurus (Bovine) - ASPH gene Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. Taurus_UMD|evm.model.AC_000171.1.301 Q3URJ8 NKAI3_MOUSE 96.894 0.535117 1.65193 Nkain3 - Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 - Mus musculus (Mouse) - Nkain3 gene membrane, regulation of sodium ion transport Taurus_UMD|evm.model.AC_000171.1.303 A7YWG4 GGH_BOVIN 100.000 0.99373 1.00314 GGH - Gamma-glutamyl hydrolase precursor - Bos taurus (Bovine) - GGH gene Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Exhibits either endo- or exopeptidase activity depending upon the tissue of origin. When secreted, it acts primarily as an endopeptidase (By similarity). Taurus_UMD|evm.model.AC_000171.1.304 P49638 TTPA_HUMAN 88.129 0.975265 1.01799 TTPA - Alpha-tocopherol transfer protein - Homo sapiens (Human) - TTPA gene Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity). Taurus_UMD|evm.model.AC_000171.1.305 Q5RFL8 YTHD3_PONAB 98.276 0.917591 1.07863 YTHDF3 - YTH domain-containing family protein 3 - Pongo abelii (Sumatran orangutan) - YTHDF3 gene Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (By similarity). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs. Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation. Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons. Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation. The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules. May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (By similarity). Taurus_UMD|evm.model.AC_000171.1.309 O09029 BHE22_MESAU 92.169 0.928977 0.964384 BHLHE22 - Class E basic helix-loop-helix protein 22 - Mesocricetus auratus (Golden hamster) - BHLHE22 gene Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA. Taurus_UMD|evm.model.AC_000171.1.310 O75881 CP7B1_HUMAN 71.915 0.923077 1.00198 CYP7B1 - Cytochrome P450 7B1 - Homo sapiens (Human) - CYP7B1 gene A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids (PubMed:10588945, PubMed:24491228). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10588945, PubMed:24491228). Catalyzes the hydroxylation of carbon hydrogen bonds of steroids with a preference for 7-alpha position (PubMed:10588945, PubMed:24491228). Usually metabolizes steroids carrying a hydroxy group at position 3, functioning as a 3-hydroxy steroid 7-alpha hydroxylase (PubMed:24491228). Hydroxylates oxysterols, including 25-hydroxycholesterol and (25R)-cholest-5-ene-3beta,26-diol toward 7-alpha hydroxy derivatives, which may be transported to the liver and converted to bile acids (PubMed:9802883, PubMed:10588945). Via its product 7-alpha,25-dihydroxycholesterol, a ligand for the chemotactic G protein-coupled receptor GPR183/EBI2, regulates B cell migration in germinal centers of lymphoid organs, thus guiding efficient maturation of plasma B cells and overall antigen-specific humoral immune response (By similarity). 7-alpha hydroxylates neurosteroids, including 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone) and pregnenolone, both involved in hippocampus-associated memory and learning (PubMed:24491228). Metabolizes androstanoids toward 6- or 7-alpha hydroxy derivatives (PubMed:24491228). Taurus_UMD|evm.model.AC_000171.1.311 Q3ZBE1 ARMC1_BOVIN 100.000 0.992933 1.00355 ARMC1 - Armadillo repeat-containing protein 1 - Bos taurus (Bovine) - ARMC1 gene In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility. Taurus_UMD|evm.model.AC_000171.1.312 Q15390 MTFR1_HUMAN 80.178 0.994083 1.01502 MTFR1 - Mitochondrial fission regulator 1 precursor - Homo sapiens (Human) - MTFR1 gene May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). Taurus_UMD|evm.model.AC_000171.1.313 Q13946 PDE7A_HUMAN 97.095 0.993802 1.00415 PDE7A - High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A - Homo sapiens (Human) - PDE7A gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. Taurus_UMD|evm.model.AC_000171.1.314 Q2KIJ8 DNJ5B_BOVIN 100.000 0.99 1.00503 DNAJC5B - DnaJ homolog subfamily C member 5B - Bos taurus (Bovine) - DNAJC5B gene Taurus_UMD|evm.model.AC_000171.1.315 Q9BYV6 TRI55_HUMAN 86.000 0.996337 0.99635 TRIM55 - Tripartite motif-containing protein 55 - Homo sapiens (Human) - TRIM55 gene May regulate gene expression and protein turnover in muscle cells. Taurus_UMD|evm.model.AC_000171.1.316 Q95MI6 CRF_BOVIN 100.000 0.989529 1.00526 CRH - Corticoliberin precursor - Bos taurus (Bovine) - CRH gene Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). Taurus_UMD|evm.model.AC_000171.1.317 A6NJL1 ZSA5B_HUMAN 66.667 0.730769 0.262626 ZSCAN5B - Zinc finger and SCAN domain-containing protein 5B - Homo sapiens (Human) - ZSCAN5B gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000171.1.318 P17480 UBF1_HUMAN 62.037 0.690789 0.198953 UBTF - Nucleolar transcription factor 1 - Homo sapiens (Human) - UBTF gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. Taurus_UMD|evm.model.AC_000171.1.319 A1YEP8 ZSC12_GORGO 55.085 0.265306 0.730132 ZSCAN12 - Zinc finger and SCAN domain-containing protein 12 - Gorilla gorilla gorilla (Western lowland gorilla) - ZSCAN12 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000171.1.320 Q2KIH4 RRS1_BOVIN 99.726 0.994536 1.00274 RRS1 - Ribosome biogenesis regulatory protein homolog - Bos taurus (Bovine) - RRS1 gene Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. Taurus_UMD|evm.model.AC_000171.1.321 A6QP15 HOT_BOVIN 99.785 0.995717 1.00215 ADHFE1 - Hydroxyacid-oxoacid transhydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ADHFE1 gene Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity). Taurus_UMD|evm.model.AC_000171.1.322 Q0VCV7 VEXIN_BOVIN 100.000 0.990196 1.00493 VXN - Vexin - Bos taurus (Bovine) - VXN gene Required for neurogenesis in the neural plate and retina. Strongly cooperates with neural bHLH factors to promote neurogenesis. Taurus_UMD|evm.model.AC_000171.1.323 P10243 MYBA_HUMAN 92.530 0.989426 0.880319 MYBL1 - Myb-related protein A - Homo sapiens (Human) - MYBL1 gene Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:8058310, PubMed:7987850). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity). Transcriptional activator of SOX30 (By similarity). Taurus_UMD|evm.model.AC_000171.1.324 Q96JH7 VCIP1_HUMAN 93.382 0.998326 0.977905 VCPIP1 - Deubiquitinating protein VCPIP1 - Homo sapiens (Human) - VCPIP1 gene Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). Taurus_UMD|evm.model.AC_000171.1.325 Q5R7A7 SGK3_PONAB 97.959 0.995927 0.989919 SGK3 - Serine/threonine-protein kinase Sgk3 - Pongo abelii (Sumatran orangutan) - SGK3 gene Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes (By similarity). Taurus_UMD|evm.model.AC_000171.1.326 Q4G0Z9 MCMD2_HUMAN 90.896 0.997067 1.00147 MCMDC2 - Minichromosome maintenance domain-containing protein 2 - Homo sapiens (Human) - MCMDC2 gene Plays an important role in meiotic recombination and associated DNA double-strand break repair. Taurus_UMD|evm.model.AC_000171.1.327 Q7RTU0 TCF24_HUMAN 89.231 0.420195 1.83832 TCF24 - Transcription factor 24 - Homo sapiens (Human) - TCF24 gene Putative transcription factor. Taurus_UMD|evm.model.AC_000171.1.328 Q4R803 PPR42_MACFA 92.453 0.970588 0.761905 PPP1R42 - Protein phosphatase 1 regulatory subunit 42 - Macaca fascicularis (Crab-eating macaque) - PPP1R42 gene Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis. Taurus_UMD|evm.model.AC_000171.1.329 Q92905 CSN5_HUMAN 99.701 0.99403 1.00299 COPS5 - COP9 signalosome complex subunit 5 - Homo sapiens (Human) - COPS5 gene Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. Taurus_UMD|evm.model.AC_000171.1.330 Q1MSJ5 CSPP1_HUMAN 85.057 0.944785 1.03822 CSPP1 - Centrosome and spindle pole-associated protein 1 - Homo sapiens (Human) - CSPP1 gene May play a role in cell-cycle-dependent microtubule organization. Taurus_UMD|evm.model.AC_000171.1.331 O46382 BIG1_BOVIN 99.946 0.998919 1.00054 ARFGEF1 - Brefeldin A-inhibited guanine nucleotide-exchange protein 1 - Bos taurus (Bovine) - ARFGEF1 gene Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined (By similarity). Taurus_UMD|evm.model.AC_000171.1.332 Q8N4T0 CBPA6_HUMAN 92.222 0.267267 0.762014 CPA6 - Carboxypeptidase A6 precursor - Homo sapiens (Human) - CPA6 gene May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II (PubMed:18178555). Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine (PubMed:20855895). Taurus_UMD|evm.model.AC_000171.1.334 Q49A92 CH034_HUMAN 90.941 0.993056 0.535316 C8orf34 - Uncharacterized protein C8orf34 - Homo sapiens (Human) - C8orf34 gene Taurus_UMD|evm.model.AC_000171.1.335 Q8BZJ8 CH034_MOUSE 76.699 0.69863 0.318083 Uncharacterized protein C8orf34 homolog - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000171.1.337 Q8IWU6 SULF1_HUMAN 87.931 0.0579858 1.12859 SULF1 - Extracellular sulfatase Sulf-1 precursor - Homo sapiens (Human) - SULF1 gene Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation. Taurus_UMD|evm.model.AC_000171.1.338 Q9H2Y9 SO5A1_HUMAN 87.897 0.997639 0.998821 SLCO5A1 - Solute carrier organic anion transporter family member 5A1 - Homo sapiens (Human) - SLCO5A1 gene integral component of plasma membrane, intracellular membrane-bounded organelle, plasma membrane, sodium-independent organic anion transmembrane transporter activity, sodium-independent organic anion transport Taurus_UMD|evm.model.AC_000171.1.340 Q9GZV8 PRD14_HUMAN 79.232 0.994755 1.00175 PRDM14 - PR domain zinc finger protein 14 - Homo sapiens (Human) - PRDM14 gene Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. Taurus_UMD|evm.model.AC_000171.1.341 Q15596 NCOA2_HUMAN 94.130 0.998636 1.00137 NCOA2 - Nuclear receptor coactivator 2 - Homo sapiens (Human) - NCOA2 gene Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Taurus_UMD|evm.model.AC_000171.1.342 Q9GKZ4 TRAM1_BOVIN 99.733 0.994667 1.00267 TRAM1 - Translocating chain-associated membrane protein 1 - Bos taurus (Bovine) - TRAM1 gene Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel. Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER. May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport. Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane. Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane. Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome. Taurus_UMD|evm.model.AC_000171.1.343 Q1LZ83 LACB2_BOVIN 100.000 0.99308 1.00347 LACTB2 - Endoribonuclease LACTB2 - Bos taurus (Bovine) - LACTB2 gene Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. Taurus_UMD|evm.model.AC_000171.1.344 Q49LR9 XKR9_PANTR 83.511 0.93299 0.520107 XKR9 - XK-related protein 9 - Pan troglodytes (Chimpanzee) - XKR9 gene membrane, plasma membrane, apoptotic process involved in development, engulfment of apoptotic cell, phosphatidylserine exposure on apoptotic cell surface Taurus_UMD|evm.model.AC_000171.1.345 Q99502 EYA1_HUMAN 97.703 0.80057 1.18581 EYA1 - Eyes absent homolog 1 - Homo sapiens (Human) - EYA1 gene Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity). Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity). Taurus_UMD|evm.model.AC_000171.1.346 O60682 MUSC_HUMAN 90.291 0.989899 0.961165 MSC - Musculin - Homo sapiens (Human) - MSC gene Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation. Taurus_UMD|evm.model.AC_000171.1.347 O75762 TRPA1_HUMAN 80.448 0.973684 1.01877 TRPA1 - Transient receptor potential cation channel subfamily A member 1 - Homo sapiens (Human) - TRPA1 gene Receptor-activated non-selective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:25855297). Shows 8-fold preference for divalent over monovalent cations (PubMed:31447178). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of irritants, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:27241698, PubMed:30878828, PubMed:20547126). Acts also as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). Is activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner, whereas mechanisms of non-electrophilic ligands are not well determined. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). Taurus_UMD|evm.model.AC_000171.1.348 Q4ZHA6 KCNB2_BOVIN 99.485 0.989744 0.21405 KCNB2 - Potassium voltage-gated channel subfamily B member 2 - Bos taurus (Bovine) - KCNB2 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Taurus_UMD|evm.model.AC_000171.1.349 Q4ZHA6 KCNB2_BOVIN 99.583 0.995845 0.792536 KCNB2 - Potassium voltage-gated channel subfamily B member 2 - Bos taurus (Bovine) - KCNB2 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Taurus_UMD|evm.model.AC_000171.1.350 P54274 TERF1_HUMAN 82.955 0.995423 0.995444 TERF1 - Telomeric repeat-binding factor 1 - Homo sapiens (Human) - TERF1 gene Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Taurus_UMD|evm.model.AC_000171.1.351 Q32L50 SBSPO_BOVIN 100.000 0.992453 1.00379 SBSPON - Somatomedin-B and thrombospondin type-1 domain-containing protein precursor - Bos taurus (Bovine) - SBSPON gene Taurus_UMD|evm.model.AC_000171.1.352 P0DMQ9 CH089_HUMAN 50.885 0.667656 2.09317 C8orf89 - Putative uncharacterized protein C8orf89 - Homo sapiens (Human) - C8orf89 gene Taurus_UMD|evm.model.AC_000171.1.353 Q58DT1 RL7_BOVIN 100.000 0.991968 1.00403 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Taurus_UMD|evm.model.AC_000171.1.354 Q8IZV5 RDH10_HUMAN 90.323 0.993528 0.906158 RDH10 - Retinol dehydrogenase 10 - Homo sapiens (Human) - RDH10 gene Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol. Taurus_UMD|evm.model.AC_000171.1.355 Q9NUL3 STAU2_HUMAN 97.050 0.89418 0.663158 STAU2 - Double-stranded RNA-binding protein Staufen homolog 2 - Homo sapiens (Human) - STAU2 gene RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). Taurus_UMD|evm.model.AC_000171.1.356 Q9NUL3 STAU2_HUMAN 96.809 0.885714 0.184211 STAU2 - Double-stranded RNA-binding protein Staufen homolog 2 - Homo sapiens (Human) - STAU2 gene RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). Taurus_UMD|evm.model.AC_000171.1.357 B5DEI4 UBE2W_RAT 100.000 0.984615 0.860927 Ube2w - Ubiquitin-conjugating enzyme E2 W - Rattus norvegicus (Rat) - Ube2w gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination occurs also in the presence of inactive RING/U-box type E3s, i.e. lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate. Taurus_UMD|evm.model.AC_000171.1.358 P83941 ELOC_RAT 100.000 0.982301 1.00893 Eloc - Elongin-C - Rattus norvegicus (Rat) - Eloc gene SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). Taurus_UMD|evm.model.AC_000171.1.359 A6H773 TMM70_BOVIN 100.000 0.875433 1.1378 TMEM70 - Transmembrane protein 70, mitochondrial precursor - Bos taurus (Bovine) - TMEM70 gene Involved in biogenesis of mitochondrial ATP synthase. Taurus_UMD|evm.model.AC_000171.1.360 P58754 LY96_BOVIN 59.375 0.984733 0.81875 LY96 - Lymphocyte antigen 96 precursor - Bos taurus (Bovine) - LY96 gene Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (By similarity). Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS. Taurus_UMD|evm.model.AC_000171.1.361 A4FV48 FADS2_BOVIN 79.487 0.954268 0.738739 FADS2 - Acyl-CoA 6-desaturase - Bos taurus (Bovine) - FADS2 gene Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). It can also desaturate (11E)-octadecenoate (trans-vaccenoate, a metabolite in the biohydrogenation pathway of LA and the predominant trans fatty acid in cow milk) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity). Taurus_UMD|evm.model.AC_000171.1.362 P83917 CBX1_MOUSE 93.333 0.593333 0.810811 Cbx1 - Chromobox protein homolog 1 - Mus musculus (Mouse) - Cbx1 gene Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Taurus_UMD|evm.model.AC_000171.1.363 Q9HDC5 JPH1_HUMAN 94.251 0.996965 0.996974 JPH1 - Junctophilin-1 - Homo sapiens (Human) - JPH1 gene Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. Taurus_UMD|evm.model.AC_000171.1.364 A6QQZ0 GDAP1_BOVIN 100.000 0.994429 1.00279 GDAP1 - Ganglioside-induced differentiation-associated protein 1 - Bos taurus (Bovine) - GDAP1 gene Regulates the mitochondrial network by promoting mitochondrial fission. Taurus_UMD|evm.model.AC_000171.1.366 O43692 PI15_HUMAN 97.674 0.992278 1.00388 PI15 - Peptidase inhibitor 15 precursor - Homo sapiens (Human) - PI15 gene Serine protease inhibitor which displays weak inhibitory activity against trypsin (PubMed:8882727). May play a role in facial patterning during embryonic development (By similarity). Taurus_UMD|evm.model.AC_000171.1.367 Q9H336 CRLD1_HUMAN 89.200 0.995807 0.954 CRISPLD1 - Cysteine-rich secretory protein LCCL domain-containing 1 precursor - Homo sapiens (Human) - CRISPLD1 gene extracellular exosome, extracellular space, face morphogenesis Taurus_UMD|evm.model.AC_000171.1.369 Q14541 HNF4G_HUMAN 96.814 0.87905 1.1348 HNF4G - Hepatocyte nuclear factor 4-gamma - Homo sapiens (Human) - HNF4G gene Transcription factor. Has a lower transcription activation potential than HNF4-alpha. Taurus_UMD|evm.model.AC_000171.1.372 Q9NR30 DDX21_HUMAN 84.848 0.912037 0.275862 DDX21 - Nucleolar RNA helicase 2 - Homo sapiens (Human) - DDX21 gene RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Taurus_UMD|evm.model.AC_000171.1.373 Q86UP3 ZFHX4_HUMAN 93.901 0.978199 0.295767 ZFHX4 - Zinc finger homeobox protein 4 - Homo sapiens (Human) - ZFHX4 gene May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000171.1.374 Q86UP3 ZFHX4_HUMAN 93.590 0.681416 0.0316793 ZFHX4 - Zinc finger homeobox protein 4 - Homo sapiens (Human) - ZFHX4 gene May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000171.1.375 Q86UP3 ZFHX4_HUMAN 92.084 0.997617 0.705915 ZFHX4 - Zinc finger homeobox protein 4 - Homo sapiens (Human) - ZFHX4 gene May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000171.1.376 A2A368 MAGBG_HUMAN 50.909 0.506977 0.66358 MAGEB16 - Melanoma-associated antigen B16 - Homo sapiens (Human) - MAGEB16 gene Taurus_UMD|evm.model.AC_000171.1.377 P28328 PEX2_HUMAN 86.513 0.990196 1.00328 PEX2 - Peroxisome biogenesis factor 2 - Homo sapiens (Human) - PEX2 gene Somewhat implicated in the biogenesis of peroxisomes. Taurus_UMD|evm.model.AC_000171.1.378 Q96LD8 SENP8_HUMAN 90.995 0.950226 1.04245 SENP8 - Sentrin-specific protease 8 - Homo sapiens (Human) - SENP8 gene Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. Taurus_UMD|evm.model.AC_000171.1.379 Q5E943 CA043_BOVIN 86.869 0.98 0.395257 Protein C1orf43 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000171.1.380 Q5E943 CA043_BOVIN 92.361 0.986207 0.573123 Protein C1orf43 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000171.1.381 P46193 ANXA1_BOVIN 94.798 0.9941 0.979769 ANXA1 - Annexin A1 - Bos taurus (Bovine) - ANXA1 gene Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T-cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (By similarity). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). Taurus_UMD|evm.model.AC_000171.1.382 Q9BWD1 THIC_HUMAN 82.468 0.854749 0.450882 ACAT2 - Acetyl-CoA acetyltransferase, cytosolic - Homo sapiens (Human) - ACAT2 gene Involved in the biosynthetic pathway of cholesterol. Taurus_UMD|evm.model.AC_000171.1.383 Q3SX13 IPKA_BOVIN 100.000 0.974026 1.01316 PKIA - cAMP-dependent protein kinase inhibitor alpha - Bos taurus (Bovine) - PKIA gene Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Taurus_UMD|evm.model.AC_000171.1.384 A4FUE7 ZC21A_BOVIN 100.000 0.804805 1.03096 ZC2HC1A - Zinc finger C2HC domain-containing protein 1A - Bos taurus (Bovine) - ZC2HC1A gene Taurus_UMD|evm.model.AC_000171.1.385 P26895 IL7_BOVIN 100.000 0.458333 1.63636 IL7 - Interleukin-7 precursor - Bos taurus (Bovine) - IL7 gene Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Taurus_UMD|evm.model.AC_000171.1.388 P55821 STMN2_MOUSE 100.000 0.988166 0.944134 Stmn2 - Stathmin-2 - Mus musculus (Mouse) - Stmn2 gene Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. Taurus_UMD|evm.model.AC_000171.1.389 Q28852 ATP5L_BOVIN 97.087 0.980769 1.00971 ATP5MG - ATP synthase subunit g, mitochondrial - Bos taurus (Bovine) - ATP5MG gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Taurus_UMD|evm.model.AC_000171.1.390 Q2KIN4 HEY1_BOVIN 100.000 0.993443 1.00329 HEY1 - Hairy/enhancer-of-split related with YRPW motif protein 1 - Bos taurus (Bovine) - HEY1 gene Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. Taurus_UMD|evm.model.AC_000171.1.391 P14851 PPIA_CRIGR 56.000 0.462264 0.646341 PPIA - Peptidyl-prolyl cis-trans isomerase A - Cricetulus griseus (Chinese hamster) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Taurus_UMD|evm.model.AC_000171.1.392 P82928 RT28_BOVIN 100.000 0.989474 1.00529 MRPS28 - 28S ribosomal protein S28, mitochondrial precursor - Bos taurus (Bovine) - MRPS28 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrial translation Taurus_UMD|evm.model.AC_000171.1.393 P55327 TPD52_HUMAN 96.045 0.946237 0.830357 TPD52 - Tumor protein D52 - Homo sapiens (Human) - TPD52 gene cytoplasm, endoplasmic reticulum, perinuclear region of cytoplasm, calcium ion binding, protein homodimerization activity, anatomical structure morphogenesis, B cell differentiation, secretion Taurus_UMD|evm.model.AC_000171.1.394 Q96DT7 ZBT10_HUMAN 93.374 0.949766 0.982778 ZBTB10 - Zinc finger and BTB domain-containing protein 10 - Homo sapiens (Human) - ZBTB10 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000171.1.396 Q6ZNC4 ZN704_HUMAN 95.157 0.940639 1.06311 ZNF704 - Zinc finger protein 704 - Homo sapiens (Human) - ZNF704 gene Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer. Taurus_UMD|evm.model.AC_000171.1.397 Q9NWQ8 PHAG1_HUMAN 81.797 0.995402 1.00694 PAG1 - Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 - Homo sapiens (Human) - PAG1 gene Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. Taurus_UMD|evm.model.AC_000171.1.398 P55052 FABP5_BOVIN 96.296 0.128713 1.4963 FABP5 - Fatty acid-binding protein 5 - Bos taurus (Bovine) - FABP5 gene Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (By similarity). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). Taurus_UMD|evm.model.AC_000171.1.399 P02690 MYP2_BOVIN 100.000 0.829114 1.19697 PMP2 - Myelin P2 protein - Bos taurus (Bovine) - PMP2 gene May play a role in lipid transport protein in Schwann cells. May bind cholesterol. Taurus_UMD|evm.model.AC_000171.1.400 Q0Z7S8 FABP9_HUMAN 71.212 0.963235 1.0303 FABP9 - Fatty acid-binding protein 9 - Homo sapiens (Human) - FABP9 gene cytosol, triglyceride catabolic process Taurus_UMD|evm.model.AC_000171.1.401 P48035 FABP4_BOVIN 99.242 0.984962 1.00758 FABP4 - Fatty acid-binding protein, adipocyte - Bos taurus (Bovine) - FABP4 gene Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Taurus_UMD|evm.model.AC_000171.1.402 Q9DAK4 FBP12_MOUSE 84.091 0.929078 1.06818 Fabp12 - Fatty acid-binding protein 12 - Mus musculus (Mouse) - Fabp12 gene May play a role in lipid transport. Taurus_UMD|evm.model.AC_000171.1.403 P48745 CCN3_HUMAN 80.636 0.969101 0.997199 CCN3 - CCN family member 3 precursor - Homo sapiens (Human) - CCN3 gene Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891). Taurus_UMD|evm.model.AC_000171.1.404 A2VE13 MAL2_BOVIN 100.000 0.988701 1.00568 MAL2 - Protein MAL2 - Bos taurus (Bovine) - MAL2 gene Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway (By similarity). Taurus_UMD|evm.model.AC_000171.1.405 Q9Y6Z7 COL10_HUMAN 85.199 0.992126 0.916968 COLEC10 - Collectin-10 precursor - Homo sapiens (Human) - COLEC10 gene Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine (PubMed:10224141). Acts as a chemoattractant, probably involved in the regulation of cell migration (PubMed:28301481). Taurus_UMD|evm.model.AC_000171.1.406 A5D7R1 TR11B_BOVIN 100.000 0.995037 1.00249 TNFRSF11B - Tumor necrosis factor receptor superfamily member 11B precursor - Bos taurus (Bovine) - TNFRSF11B gene Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity). Taurus_UMD|evm.model.AC_000171.1.407 Q5RDW3 SAM12_PONAB 95.946 0.907407 0.80597 SAMD12 - Sterile alpha motif domain-containing protein 12 - Pongo abelii (Sumatran orangutan) - SAMD12 gene Taurus_UMD|evm.model.AC_000171.1.409 A5D7I4 EXT1_BOVIN 100.000 0.997323 1.00134 EXT1 - Exostosin-1 - Bos taurus (Bovine) - EXT1 gene Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Taurus_UMD|evm.model.AC_000171.1.411 Q2YDF2 MED30_BOVIN 100.000 0.814607 0.92228 MED30 - Mediator of RNA polymerase II transcription subunit 30 - Bos taurus (Bovine) - MED30 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Taurus_UMD|evm.model.AC_000171.1.413 Q8IWU4 ZNT8_HUMAN 89.583 0.489583 0.260163 SLC30A8 - Zinc transporter 8 - Homo sapiens (Human) - SLC30A8 gene Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. Taurus_UMD|evm.model.AC_000171.1.414 Q8IWU4 ZNT8_HUMAN 75.172 0.953642 0.409214 SLC30A8 - Zinc transporter 8 - Homo sapiens (Human) - SLC30A8 gene Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. Taurus_UMD|evm.model.AC_000171.1.415 Q4LEZ3 AARD_HUMAN 55.128 0.987013 0.993548 AARD - Alanine and arginine-rich domain-containing protein - Homo sapiens (Human) - AARD gene Taurus_UMD|evm.model.AC_000171.1.416 Q3SWX9 RAD21_BOVIN 100.000 0.99683 1.00159 RAD21 - Double-strand-break repair protein rad21 homolog - Bos taurus (Bovine) - RAD21 gene As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression. Binds to and represses APOB gene promoter (By similarity). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). Taurus_UMD|evm.model.AC_000171.1.417 Q08DU1 UTP23_BOVIN 99.597 0.991968 1.00403 UTP23 - rRNA-processing protein UTP23 homolog - Bos taurus (Bovine) - UTP23 gene Involved in rRNA-processing and ribosome biogenesis. Taurus_UMD|evm.model.AC_000171.1.418 Q56JZ5 EIF3H_BOVIN 100.000 0.994334 1.00284 EIF3H - Eukaryotic translation initiation factor 3 subunit H - Bos taurus (Bovine) - EIF3H gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Taurus_UMD|evm.model.AC_000171.1.419 E1BHC3 PT100_BOVIN 88.158 0.852273 1.15789 PET100 - Protein PET100 homolog, mitochondrial precursor - Bos taurus (Bovine) - PET100 gene Plays a role in mitochondrial complex IV assembly. Taurus_UMD|evm.model.AC_000171.1.420 Q8MTV8 H4_APLCA 92.941 0.785047 1.03883 His.H4 - Histone H4 - Aplysia californica (California sea hare) - His.H4 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000171.1.421 Q9UHF7 TRPS1_HUMAN 91.886 0.92952 0.764247 TRPS1 - Zinc finger transcription factor Trps1 - Homo sapiens (Human) - TRPS1 gene Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Taurus_UMD|evm.model.AC_000171.1.423 Q9UHF7 TRPS1_HUMAN 97.744 0.992519 0.313037 TRPS1 - Zinc finger transcription factor Trps1 - Homo sapiens (Human) - TRPS1 gene Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Taurus_UMD|evm.model.AC_000171.1.424 P35705 PRDX3_BOVIN 41.969 0.982301 0.439689 PRDX3 - Thioredoxin-dependent peroxide reductase, mitochondrial precursor - Bos taurus (Bovine) - PRDX3 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Taurus_UMD|evm.model.AC_000171.1.426 Q8WVR3 TPC14_HUMAN 96.552 0.966102 0.101724 TRAPPC14 - Trafficking protein particle complex subunit 14 - Homo sapiens (Human) - TRAPPC14 gene Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether (PubMed:31467083, PubMed:30715179). TRAPP II complex has also GEF activity toward RAB1A (By similarity). TRAPPC14 is dispensable for TRAPPII complex integrity but mediates RAB3IP preciliary vesicle trafficking to the mother centriole during ciliogenesis (PubMed:31467083). Modulates YAP1 activity as transcriptional regulator (PubMed:30447097). Taurus_UMD|evm.model.AC_000171.1.427 Q80T79 CSMD3_MOUSE 99.153 0.903846 0.0701376 Csmd3 - CUB and sushi domain-containing protein 3 - Mus musculus (Mouse) - Csmd3 gene Involved in dendrite development. Taurus_UMD|evm.model.AC_000171.1.428 Q7Z407 CSMD3_HUMAN 100.000 0.982143 0.0151066 CSMD3 - CUB and sushi domain-containing protein 3 - Homo sapiens (Human) - CSMD3 gene Involved in dendrite development. Taurus_UMD|evm.model.AC_000171.1.433 Q7Z407 CSMD3_HUMAN 86.993 0.652899 0.711896 CSMD3 - CUB and sushi domain-containing protein 3 - Homo sapiens (Human) - CSMD3 gene Involved in dendrite development. Taurus_UMD|evm.model.AC_000171.1.434 Q9NY97 B3GN2_HUMAN 89.474 0.926471 0.513854 B3GNT2 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 - Homo sapiens (Human) - B3GNT2 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. Taurus_UMD|evm.model.AC_000171.1.435 Q0P583 KCNV1_BOVIN 100.000 0.992048 1 KCNV1 - Potassium voltage-gated channel subfamily V member 1 - Bos taurus (Bovine) - KCNV1 gene Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity). Taurus_UMD|evm.model.AC_000171.1.436 Q9UPR3 SMG5_HUMAN 43.738 0.995935 0.968504 SMG5 - Protein SMG5 - Homo sapiens (Human) - SMG5 gene Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. Taurus_UMD|evm.model.AC_000171.1.437 Q9NX95 SYBU_HUMAN 81.009 0.996997 1.00452 SYBU - Syntabulin - Homo sapiens (Human) - SYBU gene Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. Taurus_UMD|evm.model.AC_000171.1.438 Q865S0 RCAS1_CANLF 99.061 0.990654 1.00469 EBAG9 - Receptor-binding cancer antigen expressed on SiSo cells - Canis lupus familiaris (Dog) - EBAG9 gene May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. Taurus_UMD|evm.model.AC_000171.1.439 Q86WI1 PKHL1_HUMAN 82.985 0.999284 0.987509 PKHD1L1 - Fibrocystin-L precursor - Homo sapiens (Human) - PKHD1L1 gene cytosol, extracellular space, integral component of membrane, signaling receptor activity, immune response Taurus_UMD|evm.model.AC_000171.1.440 Q9JIX0 ENY2_MOUSE 100.000 0.980392 1.0099 Eny2 - Transcription and mRNA export factor ENY2 - Mus musculus (Mouse) - Eny2 gene Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Taurus_UMD|evm.model.AC_000171.1.441 Q96RS6 NUDC1_HUMAN 96.000 0.197605 0.859348 NUDCD1 - NudC domain-containing protein 1 - Homo sapiens (Human) - NUDCD1 gene cytosol, nucleoplasm Taurus_UMD|evm.model.AC_000171.1.442 O46639 TRFR_BOVIN 100.000 0.994987 1.00251 TRHR - Thyrotropin-releasing hormone receptor - Bos taurus (Bovine) - TRHR gene Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. Taurus_UMD|evm.model.AC_000171.1.443 Q96NL1 TMM74_HUMAN 86.230 0.993464 1.00328 TMEM74 - Transmembrane protein 74 - Homo sapiens (Human) - TMEM74 gene Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction. Taurus_UMD|evm.model.AC_000171.1.444 Q5E993 EMC2_BOVIN 100.000 0.89697 1.11111 EMC2 - ER membrane protein complex subunit 2 - Bos taurus (Bovine) - EMC2 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Taurus_UMD|evm.model.AC_000171.1.445 P24049 RL17_RAT 81.319 0.841121 0.581522 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000171.1.446 Q3T102 EIF3E_BOVIN 100.000 0.995516 1.00225 EIF3E - Eukaryotic translation initiation factor 3 subunit E - Bos taurus (Bovine) - EIF3E gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. Taurus_UMD|evm.model.AC_000171.1.447 Q8BFU0 RSPO2_MOUSE 75.355 0.987805 0.674897 Rspo2 - R-spondin-2 precursor - Mus musculus (Mouse) - Rspo2 gene Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors (PubMed:21693646). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (By similarity). Taurus_UMD|evm.model.AC_000171.1.448 Q0VCN3 IFT27_BOVIN 98.387 0.989305 1.00538 IFT27 - Intraflagellar transport protein 27 homolog - Bos taurus (Bovine) - IFT27 gene Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6. Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation. Taurus_UMD|evm.model.AC_000171.1.449 Q9Y295 DRG1_HUMAN 97.548 0.994565 1.00272 DRG1 - Developmentally-regulated GTP-binding protein 1 - Homo sapiens (Human) - DRG1 gene Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). Taurus_UMD|evm.model.AC_000171.1.450 Q9BDY8 ANGP1_PIG 100.000 0.867257 0.226908 ANGPT1 - Angiopoietin-1 precursor - Sus scrofa (Pig) - ANGPT1 gene Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity). Taurus_UMD|evm.model.AC_000171.1.451 O18920 ANGP1_BOVIN 100.000 0.91791 0.539235 ANGPT1 - Angiopoietin-1 precursor - Bos taurus (Bovine) - ANGPT1 gene Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity). Taurus_UMD|evm.model.AC_000171.1.452 O35460 ANGP1_RAT 100.000 0.725191 0.263581 Angpt1 - Angiopoietin-1 precursor - Rattus norvegicus (Rat) - Angpt1 gene Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Taurus_UMD|evm.model.AC_000171.1.453 P08548 LIN1_NYCCO 27.557 0.60221 0.430952 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Taurus_UMD|evm.model.AC_000171.1.454 O97790 TBCD1_BOVIN 79.646 0.449153 0.202575 TBC1D1 - TBC1 domain family member 1 - Bos taurus (Bovine) - TBC1D1 gene May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). Taurus_UMD|evm.model.AC_000171.1.455 O97790 TBCD1_BOVIN 80.682 0.820755 0.0909871 TBC1D1 - TBC1 domain family member 1 - Bos taurus (Bovine) - TBC1D1 gene May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). Taurus_UMD|evm.model.AC_000171.1.456 B5SNZ6 ABRA_PIG 83.377 0.994778 0.997396 ABRA - Actin-binding Rho-activating protein - Sus scrofa (Pig) - ABRA gene Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling. Taurus_UMD|evm.model.AC_000171.1.457 A5PKL1 OXR1_BOVIN 96.498 0.888756 0.958716 OXR1 - Oxidation resistance protein 1 - Bos taurus (Bovine) - OXR1 gene May be involved in protection from oxidative damage. Taurus_UMD|evm.model.AC_000171.1.458 A5PKL1 OXR1_BOVIN 97.101 0.444444 0.175459 OXR1 - Oxidation resistance protein 1 - Bos taurus (Bovine) - OXR1 gene May be involved in protection from oxidative damage. Taurus_UMD|evm.model.AC_000171.1.460 Q8WW38 FOG2_HUMAN 96.429 0.992857 0.121633 ZFPM2 - Zinc finger protein ZFPM2 - Homo sapiens (Human) - ZFPM2 gene Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). Taurus_UMD|evm.model.AC_000171.1.461 Q5R662 LRP12_PONAB 96.154 0.997599 0.969732 LRP12 - Low-density lipoprotein receptor-related protein 12 precursor - Pongo abelii (Sumatran orangutan) - LRP12 gene Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor (By similarity). Taurus_UMD|evm.model.AC_000171.1.462 Q14117 DPYS_HUMAN 86.111 0.281843 0.710983 DPYS - Dihydropyrimidinase - Homo sapiens (Human) - DPYS gene Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Taurus_UMD|evm.model.AC_000171.1.463 Q9H295 DCSTP_HUMAN 78.465 0.915851 1.08723 DCSTAMP - Dendritic cell-specific transmembrane protein - Homo sapiens (Human) - DCSTAMP gene Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions. Taurus_UMD|evm.model.AC_000171.1.464 Q9JIS1 RIMS2_RAT 100.000 0.175767 0.859807 Rims2 - Regulating synaptic membrane exocytosis protein 2 - Rattus norvegicus (Rat) - Rims2 gene Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity). Taurus_UMD|evm.model.AC_000171.1.465 Q9NV06 DCA13_HUMAN 79.104 0.840426 0.844944 DCAF13 - DDB1- and CUL4-associated factor 13 - Homo sapiens (Human) - DCAF13 gene Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Taurus_UMD|evm.model.AC_000171.1.466 Q9H2D1 MFTC_HUMAN 80.255 0.853521 1.12698 SLC25A32 - Mitochondrial folate transporter/carrier - Homo sapiens (Human) - SLC25A32 gene Transports folate across the inner membranes of mitochondria (PubMed:15140890, PubMed:29666258). Can also transport FAD across the mitochondrial inner membrane (PubMed:16165386). Taurus_UMD|evm.model.AC_000171.1.467 Q96CG8 CTHR1_HUMAN 95.473 0.991803 1.00412 CTHRC1 - Collagen triple helix repeat-containing protein 1 precursor - Homo sapiens (Human) - CTHRC1 gene May act as a negative regulator of collagen matrix deposition. Taurus_UMD|evm.model.AC_000171.1.468 Q8WMU5 FZD6_CANLF 90.336 0.997203 1.00421 FZD6 - Frizzled-6 precursor - Canis lupus familiaris (Dog) - FZD6 gene Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). Taurus_UMD|evm.model.AC_000171.1.469 Q8WNE9 BAALC_PIG 87.586 0.986301 1.0069 BAALC - Brain and acute leukemia cytoplasmic protein - Sus scrofa (Pig) - BAALC gene May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A. Taurus_UMD|evm.model.AC_000171.1.471 P21282 VATC1_BOVIN 100.000 0.994778 1.00262 ATP6V1C1 - V-type proton ATPase subunit C 1 - Bos taurus (Bovine) - ATP6V1C1 gene Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Taurus_UMD|evm.model.AC_000171.1.473 O14977 AZIN1_HUMAN 94.196 0.995546 1.00223 AZIN1 - Antizyme inhibitor 1 - Homo sapiens (Human) - AZIN1 gene Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Taurus_UMD|evm.model.AC_000171.1.474 Q13118 KLF10_HUMAN 92.357 0.67482 1.44792 KLF10 - Krueppel-like factor 10 - Homo sapiens (Human) - KLF10 gene Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. Taurus_UMD|evm.model.AC_000171.1.476 Q29438 ODFP1_BOVIN 99.618 0.992395 1.00382 ODF1 - Outer dense fiber protein 1 - Bos taurus (Bovine) - ODF1 gene Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. Taurus_UMD|evm.model.AC_000171.1.477 Q3SZ90 RL13A_BOVIN 46.154 0.938053 0.55665 RPL13A - 60S ribosomal protein L13a - Bos taurus (Bovine) - RPL13A gene Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity). Taurus_UMD|evm.model.AC_000171.1.478 O95071 UBR5_HUMAN 99.143 0.999284 0.997856 UBR5 - E3 ubiquitin-protein ligase UBR5 - Homo sapiens (Human) - UBR5 gene E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. Taurus_UMD|evm.model.AC_000171.1.479 Q5R9G0 RIR2B_PONAB 95.442 0.994318 1.00285 RRM2B - Ribonucleoside-diphosphate reductase subunit M2 B - Pongo abelii (Sumatran orangutan) - RRM2B gene Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage (By similarity). Taurus_UMD|evm.model.AC_000171.1.480 Q5PQN0 NCALD_RAT 100.000 0.989691 1.00518 Ncald - Neurocalcin-delta - Rattus norvegicus (Rat) - Ncald gene May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity). Taurus_UMD|evm.model.AC_000171.1.481 Q6ISB3 GRHL2_HUMAN 95.427 0.631274 0.8288 GRHL2 - Grainyhead-like protein 2 homolog - Homo sapiens (Human) - GRHL2 gene Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:29309642, PubMed:25152456). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity). During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity). Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity). In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293). Taurus_UMD|evm.model.AC_000171.1.482 Q9D115 ZN706_MOUSE 100.000 0.581395 1.69737 Znf706 - Zinc finger protein 706 - Mus musculus (Mouse) - Znf706 gene Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4. Taurus_UMD|evm.model.AC_000171.1.483 Q5R651 1433Z_PONAB 100.000 0.99187 1.00408 YWHAZ - 14-3-3 protein zeta/delta - Pongo abelii (Sumatran orangutan) - YWHAZ gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). Taurus_UMD|evm.model.AC_000171.1.484 P11940 PABP1_HUMAN 100.000 0.99686 1.00157 PABPC1 - Polyadenylate-binding protein 1 - Homo sapiens (Human) - PABPC1 gene Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). Taurus_UMD|evm.model.AC_000171.1.485 Q8N9S9 SNX31_HUMAN 79.856 0.680743 1.34545 SNX31 - Sorting nexin-31 - Homo sapiens (Human) - SNX31 gene May be involved in protein trafficking. Taurus_UMD|evm.model.AC_000171.1.486 Q86W74 ANR46_HUMAN 100.000 0.991266 1.00439 ANKRD46 - Ankyrin repeat domain-containing protein 46 - Homo sapiens (Human) - ANKRD46 gene Taurus_UMD|evm.model.AC_000171.1.488 Q2VJ60 RN19A_PIG 97.852 0.997616 1.00119 RNF19A - E3 ubiquitin-protein ligase RNF19A - Sus scrofa (Pig) - RNF19A gene E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Taurus_UMD|evm.model.AC_000171.1.489 Q07617 SPAG1_HUMAN 87.534 0.449204 0.882289 SPAG1 - Sperm-associated antigen 1 - Homo sapiens (Human) - SPAG1 gene May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. Taurus_UMD|evm.model.AC_000171.1.490 Q4G163 FBX43_HUMAN 79.913 0.995658 0.975989 FBXO43 - F-box only protein 43 - Homo sapiens (Human) - FBXO43 gene Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable). Taurus_UMD|evm.model.AC_000171.1.491 Q8NE09 RGS22_HUMAN 81.660 0.99682 0.995253 RGS22 - Regulator of G-protein signaling 22 - Homo sapiens (Human) - RGS22 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Taurus_UMD|evm.model.AC_000171.1.493 Q7Z7G8 VP13B_HUMAN 89.756 0.999499 0.99279 VPS13B - Vacuolar protein sorting-associated protein 13B - Homo sapiens (Human) - VPS13B gene May be involved in protein sorting in post Golgi membrane traffic. Taurus_UMD|evm.model.AC_000171.1.494 O46415 FRIL_BOVIN 60.465 0.946154 0.742857 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000171.1.495 Q3T135 OSR2_BOVIN 99.606 0.808307 1.13406 OSR2 - Protein odd-skipped-related 2 - Bos taurus (Bovine) - OSR2 gene nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific DNA binding, bone morphogenesis, embryo development ending in birth or egg hatching, embryonic skeletal system morphogenesis, eyelid development in camera-type eye, mesonephros development, metanephros development Taurus_UMD|evm.model.AC_000171.1.496 Q13188 STK3_HUMAN 99.593 0.995935 1.00204 STK3 - Serine/threonine-protein kinase 3 - Homo sapiens (Human) - STK3 gene Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38. Taurus_UMD|evm.model.AC_000171.1.497 Q9ULS6 KCNS2_HUMAN 98.950 0.993724 1.0021 KCNS2 - Potassium voltage-gated channel subfamily S member 2 - Homo sapiens (Human) - KCNS2 gene Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Taurus_UMD|evm.model.AC_000171.1.500 Q6ZUA9 MROH5_HUMAN 66.621 0.964529 0.556146 MROH5 - Maestro heat-like repeat family member 5 - Homo sapiens (Human) - MROH5 gene Taurus_UMD|evm.model.AC_000171.1.501 Q9H841 NPAL2_HUMAN 80.679 0.99446 0.942559 NIPAL2 - NIPA-like protein 2 - Homo sapiens (Human) - NIPAL2 gene membrane, magnesium ion transport Taurus_UMD|evm.model.AC_000171.1.502 Q99575 POP1_HUMAN 80.762 0.998031 0.992188 POP1 - Ribonucleases P/MRP protein subunit POP1 - Homo sapiens (Human) - POP1 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:8918471, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). Taurus_UMD|evm.model.AC_000171.1.503 Q3T114 RIDA_BOVIN 100.000 0.985507 1.0073 RIDA - 2-iminobutanoate/2-iminopropanoate deaminase - Bos taurus (Bovine) - RIDA gene Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. Taurus_UMD|evm.model.AC_000171.1.504 Q08DY0 ERIC5_BOVIN 98.226 0.945378 1.05077 ERICH5 - Glutamate-rich protein 5 - Bos taurus (Bovine) - ERICH5 gene Taurus_UMD|evm.model.AC_000171.1.505 P62890 RL30_RAT 100.000 0.982759 1.0087 Rpl30 - 60S ribosomal protein L30 - Rattus norvegicus (Rat) - Rpl30 gene cytosol, cytosolic large ribosomal subunit, nucleus, polysomal ribosome, postsynaptic density, ribosome, RNA binding, selenocysteine insertion sequence binding, structural constituent of ribosome, antimicrobial humoral immune response mediated by antimicrobial peptide Taurus_UMD|evm.model.AC_000171.1.506 O00339 MATN2_HUMAN 90.319 0.993651 0.988494 MATN2 - Matrilin-2 precursor - Homo sapiens (Human) - MATN2 gene Involved in matrix assembly. Taurus_UMD|evm.model.AC_000171.1.509 Q71SV0 LAP4B_BOVIN 99.558 0.991189 1.00442 LAPTM4B - Lysosomal-associated transmembrane protein 4B - Bos taurus (Bovine) - LAPTM4B gene Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways. Taurus_UMD|evm.model.AC_000171.1.510 Q86UE4 LYRIC_HUMAN 88.254 0.996743 1.05498 MTDH - Protein LYRIC - Homo sapiens (Human) - MTDH gene Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. Taurus_UMD|evm.model.AC_000171.1.511 P62264 RS14_MOUSE 70.248 0.979381 0.642384 Rps14 - 40S ribosomal protein S14 - Mus musculus (Mouse) - Rps14 gene cytosol, cytosolic small ribosomal subunit, mitochondrion, nucleolus, postsynaptic density, mRNA 5'-UTR binding, RNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome, translation regulator activity Taurus_UMD|evm.model.AC_000171.1.512 P62752 RL23A_RAT 98.718 0.987261 1.00641 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000171.1.513 Q64152 BTF3_MOUSE 92.357 0.981013 0.77451 Btf3 - Transcription factor BTF3 - Mus musculus (Mouse) - Btf3 gene When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription (By similarity). Taurus_UMD|evm.model.AC_000171.1.514 Q86VY4 TSYL5_HUMAN 88.426 0.990698 0.515588 TSPYL5 - Testis-specific Y-encoded-like protein 5 - Homo sapiens (Human) - TSPYL5 gene Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. Taurus_UMD|evm.model.AC_000171.1.515 P31942 HNRH3_HUMAN 98.140 0.990741 0.624277 HNRNPH3 - Heterogeneous nuclear ribonucleoprotein H3 - Homo sapiens (Human) - HNRNPH3 gene Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction. Taurus_UMD|evm.model.AC_000171.1.516 Q17QK3 CBPQ_BOVIN 98.144 0.970655 0.938559 CPQ - Carboxypeptidase Q precursor - Bos taurus (Bovine) - CPQ gene Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor (By similarity). Taurus_UMD|evm.model.AC_000171.1.518 Q58DD4 SDC2_BOVIN 100.000 0.990148 1.00495 SDC2 - Syndecan-2 precursor - Bos taurus (Bovine) - SDC2 gene Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity). Taurus_UMD|evm.model.AC_000171.1.519 Q2KHY9 PTSS1_BOVIN 100.000 0.995781 1.00211 PTDSS1 - Phosphatidylserine synthase 1 - Bos taurus (Bovine) - PTDSS1 gene Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity). Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity). Taurus_UMD|evm.model.AC_000171.1.520 P00129 QCR7_BOVIN 100.000 0.127055 6.02703 UQCRB - Cytochrome b-c1 complex subunit 7 - Bos taurus (Bovine) - UQCRB gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Taurus_UMD|evm.model.AC_000171.1.521 P55106 GDF6_BOVIN 99.698 0.497738 1.41064 GDF6 - Growth/differentiation factor 6 precursor - Bos taurus (Bovine) - GDF6 gene Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG. Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38. Taurus_UMD|evm.model.AC_000171.1.523 Q4R7Y2 RL10_MACFA 74.627 0.381503 0.808411 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000171.1.524 E1BC52 CH037_BOVIN 100.000 0.990385 1.00483 Protein C8orf37 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000171.1.525 Q9H8W4 PKHF2_HUMAN 98.394 0.992 1.00402 PLEKHF2 - Pleckstrin homology domain-containing family F member 2 - Homo sapiens (Human) - PLEKHF2 gene May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467). Taurus_UMD|evm.model.AC_000171.1.526 A7YVD7 NDUF6_BOVIN 100.000 0.994012 1.003 NDUFAF6 - NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 precursor - Bos taurus (Bovine) - NDUFAF6 gene Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of complex I subunit MT-ND1. Taurus_UMD|evm.model.AC_000171.1.528 Q96A56 T53I1_HUMAN 90.833 0.991701 1.00417 TP53INP1 - Tumor protein p53-inducible nuclear protein 1 - Homo sapiens (Human) - TP53INP1 gene Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. Taurus_UMD|evm.model.AC_000171.1.529 Q75QN2 INT8_HUMAN 98.760 0.646113 0.374874 INTS8 - Integrator complex subunit 8 - Homo sapiens (Human) - INTS8 gene Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Taurus_UMD|evm.model.AC_000171.1.530 Q5E9K7 CCNE2_BOVIN 98.828 0.269556 2.34158 CCNE2 - G1/S-specific cyclin-E2 - Bos taurus (Bovine) - CCNE2 gene Essential for the control of the cell cycle at the late G1 and early S phase. Taurus_UMD|evm.model.AC_000171.1.531 Q5R8N9 D19L4_PONAB 95.735 0.937845 1.05539 DPY19L4 - Probable C-mannosyltransferase DPY19L4 - Pongo abelii (Sumatran orangutan) - DPY19L4 gene Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Taurus_UMD|evm.model.AC_000171.1.532 Q6NXG1 ESRP1_HUMAN 97.210 0.997067 1.00147 ESRP1 - Epithelial splicing regulatory protein 1 - Homo sapiens (Human) - ESRP1 gene mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). Taurus_UMD|evm.model.AC_000171.1.533 Q69YN4 VIR_HUMAN 97.737 0.998897 1.00055 VIRMA - Protein virilizer homolog - Homo sapiens (Human) - VIRMA gene Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). Taurus_UMD|evm.model.AC_000171.1.534 Q9Y620 RA54B_HUMAN 85.699 0.962845 1.03516 RAD54B - DNA repair and recombination protein RAD54B - Homo sapiens (Human) - RAD54B gene Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group. Taurus_UMD|evm.model.AC_000171.1.535 P55040 GEM_HUMAN 94.595 0.945513 1.05405 GEM - GTP-binding protein GEM - Homo sapiens (Human) - GEM gene Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Taurus_UMD|evm.model.AC_000171.1.536 Q12864 CAD17_HUMAN 78.005 0.997599 1.0012 CDH17 - Cadherin-17 precursor - Homo sapiens (Human) - CDH17 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. Taurus_UMD|evm.model.AC_000171.1.537 P35816 PDP1_BOVIN 100.000 0.905565 1.10223 PDP1 - [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial precursor - Bos taurus (Bovine) - PDP1 gene Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. Taurus_UMD|evm.model.AC_000171.1.538 P61959 SUMO2_RAT 80.000 0.621359 1.08421 Sumo2 - Small ubiquitin-related modifier 2 precursor - Rattus norvegicus (Rat) - Sumo2 gene Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity). Taurus_UMD|evm.model.AC_000171.1.539 Q5HYA8 MKS3_HUMAN 84.739 0.997879 0.947739 TMEM67 - Meckelin precursor - Homo sapiens (Human) - TMEM67 gene Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). Taurus_UMD|evm.model.AC_000171.1.540 Q8IXT5 RB12B_HUMAN 84.915 0.99797 0.984016 RBM12B - RNA-binding protein 12B - Homo sapiens (Human) - RBM12B gene nucleoplasm, ribonucleoprotein complex, RNA binding, regulation of RNA splicing Taurus_UMD|evm.model.AC_000171.1.541 Q3SZG6 FA92A_BOVIN 98.566 0.982206 0.975694 FAM92A - Protein FAM92A - Bos taurus (Bovine) - FAM92A gene Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Probable regulator of ciliogenesis involved in limb morphogenesis. In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis. Taurus_UMD|evm.model.AC_000171.1.542 O77737 B2CL1_PIG 80.000 0.963415 0.351931 BCL2L1 - Bcl-2-like protein 1 - Sus scrofa (Pig) - BCL2L1 gene Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). Taurus_UMD|evm.model.AC_000171.1.545 Q5RDR6 TRIQK_PONAB 98.077 0.31677 1.87209 TRIQK - Triple QxxK/R motif-containing protein - Pongo abelii (Sumatran orangutan) - TRIQK gene May play a role in cell growth and maintenance of cell morphology. Taurus_UMD|evm.model.AC_000171.1.546 Q06455 MTG8_HUMAN 99.172 0.996689 1 RUNX1T1 - Protein CBFA2T1 - Homo sapiens (Human) - RUNX1T1 gene Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199, PubMed:10688654). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). Taurus_UMD|evm.model.AC_000171.1.547 Q8TE54 S26A7_HUMAN 83.835 0.881579 1.04268 SLC26A7 - Anion exchange transporter - Homo sapiens (Human) - SLC26A7 gene Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion. Taurus_UMD|evm.model.AC_000171.1.548 Q6ZNQ3 LRC69_HUMAN 75.556 0.985294 0.391931 LRRC69 - Leucine-rich repeat-containing protein 69 - Homo sapiens (Human) - LRRC69 gene signal transduction Taurus_UMD|evm.model.AC_000171.1.549 Q9D9Q0 LRC69_MOUSE 75.000 0.933824 0.391931 Lrrc69 - Leucine-rich repeat-containing protein 69 - Mus musculus (Mouse) - Lrrc69 gene signal transduction Taurus_UMD|evm.model.AC_000171.1.550 Q8N6M0 OTU6B_HUMAN 90.444 0.993197 1.00341 OTUD6B - Deubiquitinase OTUD6B - Homo sapiens (Human) - OTUD6B gene Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334). May also play a role in proteasome assembly and function (PubMed:28343629). Taurus_UMD|evm.model.AC_000171.1.551 Q3SZ48 PP4P2_BOVIN 92.692 0.992063 0.980545 PIP4P2 - Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase - Bos taurus (Bovine) - PIP4P2 gene Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity). Taurus_UMD|evm.model.AC_000171.1.552 P0DMB2 CH088_HUMAN 94.872 0.966387 1.01709 C8orf88 - Uncharacterized protein C8orf88 - Homo sapiens (Human) - C8orf88 gene cytoplasm, eukaryotic initiation factor 4E binding, negative regulation of translational initiation Taurus_UMD|evm.model.AC_000171.1.553 P27117 DCOR_BOVIN 92.593 0.934783 0.997831 ODC1 - Ornithine decarboxylase - Bos taurus (Bovine) - ODC1 gene Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Taurus_UMD|evm.model.AC_000171.1.554 Q3U145 TMM64_MOUSE 94.161 0.807122 0.884514 Tmem64 - Transmembrane protein 64 - Mus musculus (Mouse) - Tmem64 gene Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (PubMed:23395171). Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1 (PubMed:25979161). Taurus_UMD|evm.model.AC_000171.1.555 P04467 CALB1_BOVIN 100.000 0.992366 1.00383 CALB1 - Calbindin - Bos taurus (Bovine) - CALB1 gene Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Taurus_UMD|evm.model.AC_000171.1.556 Q16698 DECR_HUMAN 90.566 0.960606 0.985075 DECR1 - 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial precursor - Homo sapiens (Human) - DECR1 gene Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Taurus_UMD|evm.model.AC_000171.1.557 O60934 NBN_HUMAN 78.864 0.997351 1.00133 NBN - Nibrin - Homo sapiens (Human) - NBN gene Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex. Taurus_UMD|evm.model.AC_000171.1.558 Q9Y236 OSGI2_HUMAN 92.095 0.916515 1.09109 OSGIN2 - Oxidative stress-induced growth inhibitor 2 - Homo sapiens (Human) - OSGIN2 gene May be involved in meiosis or the maturation of germ cells. Taurus_UMD|evm.model.AC_000171.1.559 Q3SZJ2 RIPK2_BOVIN 100.000 0.996303 1.00185 RIPK2 - Receptor-interacting serine/threonine-protein kinase 2 - Bos taurus (Bovine) - RIPK2 gene Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is release from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (By similarity). Plays a role in the inactivation of RHOA in response to NGFR signaling (By similarity). Taurus_UMD|evm.model.AC_000171.1.561 P51512 MMP16_HUMAN 98.759 0.989455 0.937397 MMP16 - Matrix metalloproteinase-16 precursor - Homo sapiens (Human) - MMP16 gene Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. Taurus_UMD|evm.model.AC_000171.1.562 P58353 GTR5_BOVIN 97.970 0.975124 0.401198 SLC2A5 - Solute carrier family 2, facilitated glucose transporter member 5 - Bos taurus (Bovine) - SLC2A5 gene Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake. Taurus_UMD|evm.model.AC_000171.1.563 Q9JIK5 DDX21_MOUSE 58.240 0.808743 0.645123 Ddx21 - Nucleolar RNA helicase 2 - Mus musculus (Mouse) - Ddx21 gene RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (By similarity). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (By similarity). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification (By similarity). Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (By similarity). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (By similarity). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (By similarity). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (By similarity). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (By similarity). Involved in rRNA processing. May bind to specific miRNA hairpins (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (PubMed:21703541). Taurus_UMD|evm.model.AC_000171.1.564 Q8NA66 CNBD1_HUMAN 72.120 0.835294 1.16972 CNBD1 - Cyclic nucleotide-binding domain-containing protein 1 - Homo sapiens (Human) - CNBD1 gene Taurus_UMD|evm.model.AC_000171.1.566 Q8MJD7 CNGB3_CANLF 80.265 0.99239 0.840153 CNGB3 - Cyclic nucleotide-gated cation channel beta-3 - Canis lupus familiaris (Dog) - CNGB3 gene Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity). Taurus_UMD|evm.model.AC_000171.1.567 O75131 CPNE3_HUMAN 95.310 0.840442 1.17877 CPNE3 - Copine-3 - Homo sapiens (Human) - CPNE3 gene Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870). Taurus_UMD|evm.model.AC_000171.1.568 Q32KL4 RMD1_BOVIN 100.000 0.993711 1.00315 RMDN1 - Regulator of microtubule dynamics protein 1 - Bos taurus (Bovine) - RMDN1 gene cytoplasm, mitotic spindle pole, spindle microtubule, microtubule binding Taurus_UMD|evm.model.AC_000171.1.569 Q9H0M0 WWP1_HUMAN 93.492 0.997831 1 WWP1 - NEDD4-like E3 ubiquitin-protein ligase WWP1 - Homo sapiens (Human) - WWP1 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. Taurus_UMD|evm.model.AC_000171.1.570 P40925 MDHC_HUMAN 46.429 0.722892 0.497006 MDH1 - Malate dehydrogenase, cytoplasmic - Homo sapiens (Human) - MDH1 gene Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Taurus_UMD|evm.model.AC_000171.1.571 Q8TCU3 S7A13_HUMAN 61.111 0.966942 0.257447 SLC7A13 - Solute carrier family 7 member 13 - Homo sapiens (Human) - SLC7A13 gene Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner. Taurus_UMD|evm.model.AC_000171.1.572 Q2KJB6 VA0D2_BOVIN 99.482 0.673684 0.811966 ATP6V0D2 - V-type proton ATPase subunit d 2 - Bos taurus (Bovine) - ATP6V0D2 gene Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). Taurus_UMD|evm.model.AC_000171.1.575 P00921 CAH2_BOVIN 100.000 0.990148 0.780769 CA2 - Carbonic anhydrase 2 - Bos taurus (Bovine) - CA2 gene Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Taurus_UMD|evm.model.AC_000171.1.576 Q3SZX4 CAH3_BOVIN 100.000 0.992337 1.00385 CA3 - Carbonic anhydrase 3 - Bos taurus (Bovine) - CA3 gene Reversible hydration of carbon dioxide. Taurus_UMD|evm.model.AC_000171.1.577 Q1LZA1 CAH1_BOVIN 100.000 0.992366 1.00383 CA1 - Carbonic anhydrase 1 - Bos taurus (Bovine) - CA1 gene Reversible hydration of carbon dioxide. Taurus_UMD|evm.model.AC_000171.1.578 Q1LZA1 CAH1_BOVIN 96.935 0.992366 1.00383 CA1 - Carbonic anhydrase 1 - Bos taurus (Bovine) - CA1 gene Reversible hydration of carbon dioxide. Taurus_UMD|evm.model.AC_000171.1.579 Q1LZA1 CAH1_BOVIN 100.000 0.601852 0.413793 CA1 - Carbonic anhydrase 1 - Bos taurus (Bovine) - CA1 gene Reversible hydration of carbon dioxide. Taurus_UMD|evm.model.AC_000171.1.580 Q9D6N1 CAH13_MOUSE 89.272 0.988593 1.00382 Ca13 - Carbonic anhydrase 13 - Mus musculus (Mouse) - Ca13 gene Reversible hydration of carbon dioxide. Taurus_UMD|evm.model.AC_000171.1.581 Q8N0T1 RBIS_HUMAN 83.000 0.980198 1.01 RBIS - Ribosomal biogenesis factor - Homo sapiens (Human) - RBIS gene Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production. Taurus_UMD|evm.model.AC_000171.1.582 Q15329 E2F5_HUMAN 87.960 0.943144 0.864162 E2F5 - Transcription factor E2F5 - Homo sapiens (Human) - E2F5 gene Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Taurus_UMD|evm.model.AC_000171.1.583 Q9C099 LRCC1_HUMAN 83.301 0.988327 0.996124 LRRCC1 - Leucine-rich repeat and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - LRRCC1 gene Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis. Taurus_UMD|evm.model.AC_000171.1.584 Q91WN3 S7A13_MOUSE 52.878 0.977035 1.00209 Slc7a13 - Solute carrier family 7 member 13 - Mus musculus (Mouse) - Slc7a13 gene Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner. Taurus_UMD|evm.model.AC_000171.1.585 Q5RKI7 S7A13_RAT 54.757 0.961303 1.02505 Slc7a13 - Solute carrier family 7 member 13 - Rattus norvegicus (Rat) - Slc7a13 gene Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner. Taurus_UMD|evm.model.AC_000171.1.596 Q3ZCJ7 TBA1C_BOVIN 88.462 0.6375 0.178174 TUBA1C - Tubulin alpha-1C chain - Bos taurus (Bovine) - TUBA1C gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Taurus_UMD|evm.model.AC_000171.1.597 P02552 TBA1_CHICK 86.047 0.97561 0.199029 Tubulin alpha-1 chain - Gallus gallus (Chicken) Taurus_UMD|evm.model.AC_000171.1.598 P57768 SNX16_HUMAN 88.630 0.994186 1 SNX16 - Sorting nexin-16 - Homo sapiens (Human) - SNX16 gene May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. Taurus_UMD|evm.model.AC_000171.1.599 Q96CF2 CHM4C_HUMAN 88.559 0.79932 1.2618 CHMP4C - Charged multivesicular body protein 4c - Homo sapiens (Human) - CHMP4C gene Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission (PubMed:22422861, PubMed:24814515). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Taurus_UMD|evm.model.AC_000171.1.600 Q8TCF1 ZFAN1_HUMAN 85.448 0.992565 1.00373 ZFAND1 - AN1-type zinc finger protein 1 - Homo sapiens (Human) - ZFAND1 gene Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830). Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830). This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830). Taurus_UMD|evm.model.AC_000171.1.601 Q5PT55 NTCP5_HUMAN 77.294 0.98861 1.00228 SLC10A5 - Sodium/bile acid cotransporter 5 precursor - Homo sapiens (Human) - SLC10A5 gene bile acid:sodium symporter activity, bile acid and bile salt transport Taurus_UMD|evm.model.AC_000171.1.602 P20456 IMPA1_BOVIN 100.000 0.841463 1.18412 IMPA1 - Inositol monophosphatase 1 - Bos taurus (Bovine) - IMPA1 gene Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate. Taurus_UMD|evm.model.AC_000171.1.603 A1A4K5 ENPP2_BOVIN 97.039 0.970387 0.988739 ENPP2 - Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 precursor - Bos taurus (Bovine) - ENPP2 gene Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine (PubMed:12119361). Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor (By similarity). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity). Taurus_UMD|evm.model.AC_000171.1.604 Q8C176 TAF2_MOUSE 97.366 0.616635 1.44837 Taf2 - Transcription initiation factor TFIID subunit 2 - Mus musculus (Mouse) - Taf2 gene Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter (By similarity). Taurus_UMD|evm.model.AC_000171.1.605 Q8TB45 DPTOR_HUMAN 94.430 0.942356 0.97555 DEPTOR - DEP domain-containing mTOR-interacting protein - Homo sapiens (Human) - DEPTOR gene Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes. Taurus_UMD|evm.model.AC_000171.1.607 Q05707 COEA1_HUMAN 90.823 0.995017 1.00557 COL14A1 - Collagen alpha-1(XIV) chain precursor - Homo sapiens (Human) - COL14A1 gene Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). Taurus_UMD|evm.model.AC_000171.1.609 Q3SYS1 RM13_BOVIN 100.000 0.988439 0.97191 MRPL13 - 39S ribosomal protein L13, mitochondrial - Bos taurus (Bovine) - MRPL13 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, ribosome, mRNA binding, structural constituent of ribosome, negative regulation of translation Taurus_UMD|evm.model.AC_000171.1.610 Q96DY7 MTBP_HUMAN 80.442 0.997775 0.994469 MTBP - Mdm2-binding protein - Homo sapiens (Human) - MTBP gene Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Taurus_UMD|evm.model.AC_000171.1.611 Q13884 SNTB1_HUMAN 77.715 0.848534 1.14126 SNTB1 - Beta-1-syntrophin - Homo sapiens (Human) - SNTB1 gene Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. Taurus_UMD|evm.model.AC_000172.1.1 Q13136 LIPA1_HUMAN 57.971 0.981651 0.0906822 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000172.1.2 Q8NH72 OR4C6_HUMAN 65.217 0.958115 0.618123 OR4C6 - Olfactory receptor 4C6 - Homo sapiens (Human) - OR4C6 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.3 Q8NGB2 OR4C5_HUMAN 50.746 0.8125 0.392638 OR4C5 - Olfactory receptor 4C5 - Homo sapiens (Human) - OR4C5 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.4 Q8NH37 OR4C3_HUMAN 58.594 0.818182 0.509934 OR4C3 - Olfactory receptor 4C3 - Homo sapiens (Human) - OR4C3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.6 Q8NGL9 OR4CG_HUMAN 75.200 0.953846 0.419355 OR4C16 - Olfactory receptor 4C16 - Homo sapiens (Human) - OR4C16 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.8 Q96RD7 PANX1_HUMAN 73.984 0.657459 0.424883 PANX1 - Pannexin-1 - Homo sapiens (Human) - PANX1 gene Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation (PubMed:16908669, PubMed:20829356, PubMed:30918116). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669). Plays a critical role in oogenesis (PubMed:30918116). Taurus_UMD|evm.model.AC_000172.1.9 Q9EQF4 JUNO_MOUSE 68.421 0.807143 0.57377 Izumo1r - Sperm-egg fusion protein Juno precursor - Mus musculus (Mouse) - Izumo1r gene Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization (PubMed:24739963, PubMed:26859261, PubMed:27309808, PubMed:27416963). The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:24739963, PubMed:26859261, PubMed:27309808). The ligand-receptor interaction probably does not act as a membrane 'fusogen' (PubMed:24739963, PubMed:26859261, PubMed:27309808). Does not bind folate (PubMed:24739963). Taurus_UMD|evm.model.AC_000172.1.10 Q9NYM4 GPR83_HUMAN 91.605 0.96875 0.983452 GPR83 - Probable G-protein coupled receptor 83 precursor - Homo sapiens (Human) - GPR83 gene Orphan receptor. Could be a neuropeptide Y receptor. Taurus_UMD|evm.model.AC_000172.1.11 P49959 MRE11_HUMAN 75.711 0.997389 1.08192 MRE11 - Double-strand break repair protein MRE11 - Homo sapiens (Human) - MRE11 gene Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). RAD50 may be required to bind DNA ends and hold them in close proximity (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289, PubMed:30612738). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). Taurus_UMD|evm.model.AC_000172.1.12 Q5EA33 ANR49_BOVIN 100.000 0.991632 1.0042 ANKRD49 - Ankyrin repeat domain-containing protein 49 - Bos taurus (Bovine) - ANKRD49 gene May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF-kappaB pathway. Taurus_UMD|evm.model.AC_000172.1.13 Q9NRN7 ADPPT_HUMAN 93.204 0.993548 1.00324 AASDHPPT - L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase - Homo sapiens (Human) - AASDHPPT gene Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN. Taurus_UMD|evm.model.AC_000172.1.15 Q8NAB2 KBTB3_HUMAN 95.207 0.993421 0.993464 KBTBD3 - Kelch repeat and BTB domain-containing protein 3 - Homo sapiens (Human) - KBTBD3 gene Taurus_UMD|evm.model.AC_000172.1.16 Q2KJB9 MSD4_BOVIN 100.000 0.99422 1.0029 MSANTD4 - Myb/SANT-like DNA-binding domain-containing protein 4 - Bos taurus (Bovine) - MSANTD4 gene Taurus_UMD|evm.model.AC_000172.1.17 P19493 GRIA4_RAT 96.176 0.980447 0.793792 Gria4 - Glutamate receptor 4 precursor - Rattus norvegicus (Rat) - Gria4 gene Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). Taurus_UMD|evm.model.AC_000172.1.18 P19493 GRIA4_RAT 96.296 0.456897 0.128603 Gria4 - Glutamate receptor 4 precursor - Rattus norvegicus (Rat) - Gria4 gene Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). Taurus_UMD|evm.model.AC_000172.1.19 Q148I1 PAAF1_BOVIN 89.764 0.984375 0.326531 PAAF1 - Proteasomal ATPase-associated factor 1 - Bos taurus (Bovine) - PAAF1 gene Inhibits proteasome 26S assembly and activity by impairing the association of the 19S regulatory complex with the 20S core. Protects SUPT6H from proteasomal degradation (By similarity). Taurus_UMD|evm.model.AC_000172.1.20 P19493 GRIA4_RAT 100.000 0.952941 0.094235 Gria4 - Glutamate receptor 4 precursor - Rattus norvegicus (Rat) - Gria4 gene Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). Taurus_UMD|evm.model.AC_000172.1.21 O75601 CASPD_BOVIN 100.000 0.460784 2.16446 CASP13 - Caspase-13 precursor - Bos taurus (Bovine) - CASP13 gene Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Taurus_UMD|evm.model.AC_000172.1.22 B0VXE8 CDK14_CALJA 86.567 0.578947 0.269504 CDK14 - Cyclin-dependent kinase 14 - Callithrix jacchus (White-tufted-ear marmoset) - CDK14 gene Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity). Taurus_UMD|evm.model.AC_000172.1.24 Q08DG8 ZN135_BOVIN 51.420 0.690945 0.773212 ZNF135 - Zinc finger protein 135 - Bos taurus (Bovine) - ZNF135 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000172.1.26 Q6V9H4 PDGFD_RABIT 94.667 0.548624 1.81667 PDGFD - Platelet-derived growth factor D precursor - Oryctolagus cuniculus (Rabbit) - PDGFD gene Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). Taurus_UMD|evm.model.AC_000172.1.28 Q8NCM8 DYHC2_HUMAN 90.697 0.999749 0.925935 DYNC2H1 - Cytoplasmic dynein 2 heavy chain 1 - Homo sapiens (Human) - DYNC2H1 gene May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity). Taurus_UMD|evm.model.AC_000172.1.29 Q1RMX9 DCNL5_BOVIN 100.000 0.991561 1.00424 DCUN1D5 - DCN1-like protein 5 - Bos taurus (Bovine) - DCUN1D5 gene Contributes to the neddylation of all cullins by transfering NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate to cell proliferation and anchorage-independent cell growth. Taurus_UMD|evm.model.AC_000172.1.30 O77656 MMP13_BOVIN 99.575 0.995763 1.00212 MMP13 - Collagenase 3 precursor - Bos taurus (Bovine) - MMP13 gene Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion (By similarity). Taurus_UMD|evm.model.AC_000172.1.32 P08254 MMP3_HUMAN 82.013 0.518354 1.8847 MMP3 - Stromelysin-1 precursor - Homo sapiens (Human) - MMP3 gene Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. Taurus_UMD|evm.model.AC_000172.1.33 P28053 MMP1_BOVIN 98.934 0.995745 1.00213 MMP1 - Interstitial collagenase precursor - Bos taurus (Bovine) - MMP1 gene Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. Taurus_UMD|evm.model.AC_000172.1.34 P28053 MMP1_BOVIN 98.847 0.347739 2.12154 MMP1 - Interstitial collagenase precursor - Bos taurus (Bovine) - MMP1 gene Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. Taurus_UMD|evm.model.AC_000172.1.35 Q9GKE1 MMP27_TUPBE 83.633 0.974609 1 MMP27 - Matrix metalloproteinase-27 precursor - Tupaia belangeri (Common tree shrew) - MMP27 gene Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens. Taurus_UMD|evm.model.AC_000172.1.36 O18767 MMP20_BOVIN 83.576 0.990476 0.873181 MMP20 - Matrix metalloproteinase-20 precursor - Bos taurus (Bovine) - MMP20 gene Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Ser-|-Phe-361' site. Taurus_UMD|evm.model.AC_000172.1.37 P09237 MMP7_HUMAN 74.046 0.949091 1.02996 MMP7 - Matrilysin precursor - Homo sapiens (Human) - MMP7 gene Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Taurus_UMD|evm.model.AC_000172.1.38 Q8N131 PORIM_HUMAN 70.968 0.315364 1.78365 TMEM123 - Porimin precursor - Homo sapiens (Human) - TMEM123 gene Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability. Taurus_UMD|evm.model.AC_000172.1.39 Q13490 BIRC2_HUMAN 89.179 0.996269 0.867314 BIRC2 - Baculoviral IAP repeat-containing protein 2 - Homo sapiens (Human) - BIRC2 gene Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. Taurus_UMD|evm.model.AC_000172.1.40 O62640 PIAP_PIG 77.831 0.712565 1.62291 PIAP - Putative inhibitor of apoptosis - Sus scrofa (Pig) - PIAP gene cytoplasm, nucleus, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ubiquitin protein ligase activity, negative regulation of apoptotic process, negative regulation of necroptotic process, positive regulation of protein ubiquitination, regulation of cell cycle Taurus_UMD|evm.model.AC_000172.1.41 P46937 YAP1_HUMAN 98.741 0.954217 0.823413 YAP1 - Transcriptional coactivator YAP1 - Homo sapiens (Human) - YAP1 gene Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750). Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Taurus_UMD|evm.model.AC_000172.1.42 Q2HJH8 CF300_BOVIN 99.625 0.992537 1.00375 CFAP300 - Cilia- and flagella-associated protein 300 - Bos taurus (Bovine) - CFAP300 gene Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly. Taurus_UMD|evm.model.AC_000172.1.43 Q9P2H0 CE126_HUMAN 71.810 0.929363 0.646374 CEP126 - Centrosomal protein of 126 kDa - Homo sapiens (Human) - CEP126 gene Participates in cytokinesis (PubMed:19799413). Necessary for microtubules and mitotic spindle organization (PubMed:24867236). Involved in primary cilium formation (PubMed:24867236). Taurus_UMD|evm.model.AC_000172.1.44 Q9P2H0 CE126_HUMAN 77.174 0.470284 0.346464 CEP126 - Centrosomal protein of 126 kDa - Homo sapiens (Human) - CEP126 gene Participates in cytokinesis (PubMed:19799413). Necessary for microtubules and mitotic spindle organization (PubMed:24867236). Involved in primary cilium formation (PubMed:24867236). Taurus_UMD|evm.model.AC_000172.1.45 Q86XS5 ANGL5_HUMAN 87.696 0.987047 0.994845 ANGPTL5 - Angiopoietin-related protein 5 precursor - Homo sapiens (Human) - ANGPTL5 gene collagen-containing extracellular matrix, extracellular space Taurus_UMD|evm.model.AC_000172.1.47 Q9MYW0 TRPC6_BOVIN 78.462 0.831169 0.0827068 TRPC6 - Short transient receptor potential channel 6 - Bos taurus (Bovine) - TRPC6 gene Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Taurus_UMD|evm.model.AC_000172.1.48 Q9MYW0 TRPC6_BOVIN 100.000 0.997639 0.909774 TRPC6 - Short transient receptor potential channel 6 - Bos taurus (Bovine) - TRPC6 gene Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Taurus_UMD|evm.model.AC_000172.1.49 P83783 SAHH_CANAL 41.026 0.640351 0.253333 SAH1 - Adenosylhomocysteinase - Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) - SAH1 gene Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Taurus_UMD|evm.model.AC_000172.1.51 P06186 PRGR_RABIT 65.237 0.716981 0.626882 PGR - Progesterone receptor - Oryctolagus cuniculus (Rabbit) - PGR gene The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Taurus_UMD|evm.model.AC_000172.1.54 A6NI28 RHG42_HUMAN 97.826 0.997714 1.00114 ARHGAP42 - Rho GTPase-activating protein 42 - Homo sapiens (Human) - ARHGAP42 gene May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. Taurus_UMD|evm.model.AC_000172.1.55 P17507 EF1A2_XENLA 56.098 0.465116 0.186551 eef1ao - Elongation factor 1-alpha, oocyte form - Xenopus laevis (African clawed frog) - eef1ao gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Taurus_UMD|evm.model.AC_000172.1.56 Q58DQ3 RL6_BOVIN 97.561 0.993056 1.00348 RPL6 - 60S ribosomal protein L6 - Bos taurus (Bovine) - RPL6 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000172.1.58 O94779 CNTN5_HUMAN 87.827 0.960155 0.935455 CNTN5 - Contactin-5 precursor - Homo sapiens (Human) - CNTN5 gene Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity). Taurus_UMD|evm.model.AC_000172.1.59 Q10126 YSM6_CAEEL 25.000 0.900662 0.541219 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000172.1.61 Q99880 H2B1L_HUMAN 88.095 0.984252 1.00794 H2BC13 - Histone H2B type 1-L - Homo sapiens (Human) - H2BC13 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000172.1.62 Q8TAE6 PP14C_HUMAN 88.824 0.988304 1.03636 PPP1R14C - Protein phosphatase 1 regulatory subunit 14C - Homo sapiens (Human) - PPP1R14C gene Inhibitor of the PP1 regulatory subunit PPP1CA. Taurus_UMD|evm.model.AC_000172.1.64 B2RRL2 JERKL_MOUSE 99.310 0.478405 0.575526 Jrkl - Jerky protein homolog-like - Mus musculus (Mouse) - Jrkl gene nucleus, DNA binding Taurus_UMD|evm.model.AC_000172.1.65 Q8N4S0 CCD82_HUMAN 72.152 0.996176 0.961397 CCDC82 - Coiled-coil domain-containing protein 82 - Homo sapiens (Human) - CCDC82 gene nucleus Taurus_UMD|evm.model.AC_000172.1.66 A5D7F6 MAML2_BOVIN 100.000 0.669261 0.227837 MAML2 - Mastermind-like protein 2 - Bos taurus (Bovine) - MAML2 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3 (By similarity). Taurus_UMD|evm.model.AC_000172.1.68 A5D7F6 MAML2_BOVIN 99.895 0.97546 0.867021 MAML2 - Mastermind-like protein 2 - Bos taurus (Bovine) - MAML2 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3 (By similarity). Taurus_UMD|evm.model.AC_000172.1.69 A6QLT2 MTMR2_BOVIN 100.000 0.966981 0.989114 MTMR2 - Myotubularin-related protein 2 - Bos taurus (Bovine) - MTMR2 gene Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Stabilizes SBF2/MTMR13 at the membranes. Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity). Taurus_UMD|evm.model.AC_000172.1.70 Q865V0 CEP57_BOVIN 99.800 0.996 1.002 CEP57 - Centrosomal protein of 57 kDa - Bos taurus (Bovine) - CEP57 gene Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2 (By similarity). Taurus_UMD|evm.model.AC_000172.1.71 Q5HYJ3 FA76B_HUMAN 99.115 0.994118 1.00295 FAM76B - Protein FAM76B - Homo sapiens (Human) - FAM76B gene nuclear speck Taurus_UMD|evm.model.AC_000172.1.72 Q3T075 STX8_BOVIN 96.078 0.980392 0.216102 STX8 - Syntaxin-8 - Bos taurus (Bovine) - STX8 gene Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER. Taurus_UMD|evm.model.AC_000172.1.76 P58005 SESN3_HUMAN 98.927 0.995717 0.949187 SESN3 - Sestrin-3 - Homo sapiens (Human) - SESN3 gene May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). Taurus_UMD|evm.model.AC_000172.1.77 O94919 ENDD1_HUMAN 76.600 0.996008 1.002 ENDOD1 - Endonuclease domain-containing 1 protein precursor - Homo sapiens (Human) - ENDOD1 gene May act as a DNase and a RNase. Taurus_UMD|evm.model.AC_000172.1.78 Q6B0I6 KDM4D_HUMAN 83.505 0.52459 0.349904 KDM4D - Lysine-specific demethylase 4D - Homo sapiens (Human) - KDM4D gene Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Taurus_UMD|evm.model.AC_000172.1.79 Q6B0I6 KDM4D_HUMAN 82.418 0.848131 0.818356 KDM4D - Lysine-specific demethylase 4D - Homo sapiens (Human) - KDM4D gene Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Taurus_UMD|evm.model.AC_000172.1.80 F1N5S9 FUND1_BOVIN 93.750 0.982301 0.729032 FUNDC1 - FUN14 domain-containing protein 1 - Bos taurus (Bovine) - FUNDC1 gene Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. Taurus_UMD|evm.model.AC_000172.1.81 B2RXH2 KDM4E_HUMAN 71.100 0.768463 0.990119 KDM4E - Lysine-specific demethylase 4E - Homo sapiens (Human) - KDM4E gene Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Taurus_UMD|evm.model.AC_000172.1.82 Q2KJD3 CWC15_BOVIN 100.000 0.991379 1.00433 CWC15 - Spliceosome-associated protein CWC15 homolog - Bos taurus (Bovine) - CWC15 gene Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Taurus_UMD|evm.model.AC_000172.1.84 E1BEQ5 AMOL1_BOVIN 99.788 0.848375 1.15417 AMOTL1 - Angiomotin-like protein 1 - Bos taurus (Bovine) - AMOTL1 gene Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Taurus_UMD|evm.model.AC_000172.1.85 Q7Z3Z4 PIWL4_HUMAN 81.081 0.974448 1.01056 PIWIL4 - Piwi-like protein 4 - Homo sapiens (Human) - PIWIL4 gene Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (By similarity). Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association (By similarity). The piRNA process acts upstream of known mediators of DNA methylation (By similarity). Does not show endonuclease activity (By similarity). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus (By similarity). May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci (PubMed:17544373). In addition to its role in germline, PIWIL4 also plays a role in the regulation of somatic cells activities. Plays a role in pancreatic beta cell function and insulin secretion (By similarity). Involved in maintaining cell morphology and functional integrity of retinal epithelial through Akt/GSK3alpha/beta signaling pathway (PubMed:28025795). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of cells proliferation in tumors (PubMed:22483988). Taurus_UMD|evm.model.AC_000172.1.86 Q8HZR3 FUT4_BOVIN 99.246 0.994987 1.00251 FUT4 - Alpha-(1,3)-fucosyltransferase 4 - Bos taurus (Bovine) - FUT4 gene May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens. Taurus_UMD|evm.model.AC_000172.1.87 F1MQW7 CK097_BOVIN 100.000 0.984252 1.00794 Uncharacterized protein C11orf97 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000172.1.88 Q2TBE0 C19L2_HUMAN 79.596 0.995343 0.96085 CWF19L2 - CWF19-like protein 2 - Homo sapiens (Human) - CWF19L2 gene post-mRNA release spliceosomal complex, mRNA splicing, via spliceosome Taurus_UMD|evm.model.AC_000172.1.89 P33402 GCYA2_HUMAN 93.579 0.997264 0.998634 GUCY1A2 - Guanylate cyclase soluble subunit alpha-2 - Homo sapiens (Human) - GUCY1A2 gene Has guanylyl cyclase on binding to the beta-1 subunit. Taurus_UMD|evm.model.AC_000172.1.90 A1A4L5 ALKB8_BOVIN 90.592 0.394663 1.07229 ALKBH8 - Alkylated DNA repair protein alkB homolog 8 - Bos taurus (Bovine) - ALKBH8 gene Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis (By similarity). Taurus_UMD|evm.model.AC_000172.1.92 Q0IIE6 ELMD1_BOVIN 100.000 0.993884 1.00307 ELMOD1 - ELMO domain-containing protein 1 - Bos taurus (Bovine) - ELMOD1 gene Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Taurus_UMD|evm.model.AC_000172.1.93 Q8IXU6 S35F2_HUMAN 92.781 0.994609 0.991979 SLC35F2 - Solute carrier family 35 member F2 - Homo sapiens (Human) - SLC35F2 gene Putative solute transporter. Taurus_UMD|evm.model.AC_000172.1.94 Q14964 RB39A_HUMAN 98.618 0.990826 1.00461 RAB39A - Ras-related protein Rab-39A - Homo sapiens (Human) - RAB39A gene Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K (PubMed:24349490). May be involved in multiple neurite formation (By similarity). Taurus_UMD|evm.model.AC_000172.1.95 Q93034 CUL5_HUMAN 100.000 0.997439 1.00128 CUL5 - Cullin-5 - Homo sapiens (Human) - CUL5 gene Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. Taurus_UMD|evm.model.AC_000172.1.96 Q29RZ0 THIL_BOVIN 100.000 0.905376 1.1019 ACAT1 - Acetyl-CoA acetyltransferase, mitochondrial precursor - Bos taurus (Bovine) - ACAT1 gene This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Taurus_UMD|evm.model.AC_000172.1.97 Q14207 NPAT_HUMAN 80.388 0.998605 1.00491 NPAT - Protein NPAT - Homo sapiens (Human) - NPAT gene Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. Taurus_UMD|evm.model.AC_000172.1.98 Q13315 ATM_HUMAN 89.823 0.999345 0.999673 ATM - Serine-protein kinase ATM - Homo sapiens (Human) - ATM gene Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:9843217, PubMed:9733515, PubMed:10550055, PubMed:10766245, PubMed:10839545, PubMed:10910365, PubMed:10802669, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:30612738, PubMed:30886146). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Taurus_UMD|evm.model.AC_000172.1.99 Q4R8C7 AIDA_MACFA 97.959 0.713235 0.494545 AIDA - Axin interactor, dorsalization-associated protein - Macaca fascicularis (Crab-eating macaque) - AIDA gene Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). Taurus_UMD|evm.model.AC_000172.1.100 Q4R8C7 AIDA_MACFA 98.582 0.985915 0.516364 AIDA - Axin interactor, dorsalization-associated protein - Macaca fascicularis (Crab-eating macaque) - AIDA gene Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). Taurus_UMD|evm.model.AC_000172.1.101 Q7Z4H8 PLGT3_HUMAN 91.189 0.956778 1.00394 POGLUT3 - Protein O-glucosyltransferase 3 precursor - Homo sapiens (Human) - POGLUT3 gene Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1 and NOTCH3 (PubMed:30127001). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001). Taurus_UMD|evm.model.AC_000172.1.102 Q8NEV8 EXPH5_HUMAN 78.346 0.988281 0.128708 EXPH5 - Exophilin-5 - Homo sapiens (Human) - EXPH5 gene May act as Rab effector protein and play a role in vesicle trafficking. Taurus_UMD|evm.model.AC_000172.1.103 Q8NEV8 EXPH5_HUMAN 64.908 0.980508 0.851181 EXPH5 - Exophilin-5 - Homo sapiens (Human) - EXPH5 gene May act as Rab effector protein and play a role in vesicle trafficking. Taurus_UMD|evm.model.AC_000172.1.104 Q0VAV2 EXPH5_MOUSE 90.000 0.239264 0.0831633 Exph5 - Exophilin-5 - Mus musculus (Mouse) - Exph5 gene May act as Rab effector protein and play a role in vesicle trafficking. Taurus_UMD|evm.model.AC_000172.1.105 Q13206 DDX10_HUMAN 85.324 0.997628 0.963429 DDX10 - Probable ATP-dependent RNA helicase DDX10 - Homo sapiens (Human) - DDX10 gene Putative ATP-dependent RNA helicase. Taurus_UMD|evm.model.AC_000172.1.107 Q9BGX9 CK087_MACFA 81.500 0.506427 1.97462 QflA-11381 - Uncharacterized protein C11orf87 homolog precursor - Macaca fascicularis (Crab-eating macaque) - QflA-11381 gene Taurus_UMD|evm.model.AC_000172.1.108 Q32P51 RA1L2_HUMAN 90.698 0.304348 0.43125 HNRNPA1L2 - Heterogeneous nuclear ribonucleoprotein A1-like 2 - Homo sapiens (Human) - HNRNPA1L2 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. Taurus_UMD|evm.model.AC_000172.1.109 Q28521 ROA1_MACMU 88.182 0.939655 0.3625 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Macaca mulatta (Rhesus macaque) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins (By similarity). Taurus_UMD|evm.model.AC_000172.1.110 A2Q0Z0 EF1A1_HORSE 62.097 0.968 0.270563 EEF1A1 - Elongation factor 1-alpha 1 - Equus caballus (Horse) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000172.1.111 Q9C0D7 ZC12C_HUMAN 92.141 0.989831 1.00227 ZC3H12C - Probable ribonuclease ZC3H12C - Homo sapiens (Human) - ZC3H12C gene May function as RNase and regulate the levels of target RNA species. Taurus_UMD|evm.model.AC_000172.1.112 Q32LP2 RADI_BOVIN 100.000 0.961983 1.03774 RDX - Radixin - Bos taurus (Bovine) - RDX gene Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. Taurus_UMD|evm.model.AC_000172.1.113 Q5E954 DNJA1_BOVIN 97.764 0.99361 0.788413 DNAJA1 - DnaJ homolog subfamily A member 1 precursor - Bos taurus (Bovine) - DNAJA1 gene Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Taurus_UMD|evm.model.AC_000172.1.114 P00257 ADX_BOVIN 100.000 0.989305 1.00538 FDX1 - Adrenodoxin, mitochondrial precursor - Bos taurus (Bovine) - FDX1 gene Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage to produce pregnenolone, the precursor of most steroid hormones. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons. Taurus_UMD|evm.model.AC_000172.1.115 Q9P2F6 RHG20_HUMAN 84.719 0.998314 0.995802 ARHGAP20 - Rho GTPase-activating protein 20 - Homo sapiens (Human) - ARHGAP20 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000172.1.116 P15880 RS2_HUMAN 99.333 0.943038 0.539249 RPS2 - 40S ribosomal protein S2 - Homo sapiens (Human) - RPS2 gene cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleoplasm, nucleus, cadherin binding, enzyme binding Taurus_UMD|evm.model.AC_000172.1.117 Q8IXP5 CK053_HUMAN 76.419 0.986957 0.974576 C11orf53 - Uncharacterized protein C11orf53 - Homo sapiens (Human) - C11orf53 gene Taurus_UMD|evm.model.AC_000172.1.118 A8K830 COLC2_HUMAN 67.532 0.729469 1.34416 COLCA2 - Colorectal cancer-associated protein 2 - Homo sapiens (Human) - COLCA2 gene cytoplasm Taurus_UMD|evm.model.AC_000172.1.119 Q2KJA4 OBF1_BOVIN 100.000 0.992218 1.00391 POU2AF1 - POU domain class 2-associating factor 1 - Bos taurus (Bovine) - POU2AF1 gene Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator. Taurus_UMD|evm.model.AC_000172.1.122 Q9NY30 BTG4_HUMAN 83.784 0.96087 1.03139 BTG4 - Protein BTG4 - Homo sapiens (Human) - BTG4 gene Shows marked antiproliferative activity, being able to induce G(1) arrest. Taurus_UMD|evm.model.AC_000172.1.123 Q32P68 HOATZ_BOVIN 88.095 0.986577 0.886905 HOATZ - Cilia- and flagella-associated protein HOATZ - Bos taurus (Bovine) - HOATZ gene Required for motile ciliogenesis and flagellar genesis by mediating the maturation of the glycolytic enzyme ENO4. Taurus_UMD|evm.model.AC_000172.1.124 Q6UX15 LAYN_HUMAN 80.716 0.94385 0.979058 LAYN - Layilin precursor - Homo sapiens (Human) - LAYN gene Receptor for hyaluronate. Taurus_UMD|evm.model.AC_000172.1.125 Q9H0K1 SIK2_HUMAN 87.689 0.99779 0.977322 SIK2 - Serine/threonine-protein kinase SIK2 - Homo sapiens (Human) - SIK2 gene Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Taurus_UMD|evm.model.AC_000172.1.126 P54613 2AAB_PIG 97.492 0.852857 1.16279 PPP2R1B - Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform - Sus scrofa (Pig) - PPP2R1B gene The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Taurus_UMD|evm.model.AC_000172.1.127 Q9H6U8 ALG9_HUMAN 95.902 0.977528 1.01964 ALG9 - Alpha-1,2-mannosyltransferase ALG9 - Homo sapiens (Human) - ALG9 gene Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides. Taurus_UMD|evm.model.AC_000172.1.128 Q9BRP7 FDXA1_HUMAN 81.090 0.9968 1.0016 FDXACB1 - Ferredoxin-fold anticodon-binding domain-containing protein 1 - Homo sapiens (Human) - FDXACB1 gene cytoplasm, rRNA (uridine-N3-)-methyltransferase activity, rRNA base methylation Taurus_UMD|evm.model.AC_000172.1.129 Q2T9Q3 CK001_BOVIN 100.000 0.359813 1.26627 UPF0686 protein C11orf1 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000172.1.130 P02510 CRYAB_BOVIN 100.000 0.988636 1.00571 CRYAB - Alpha-crystallin B chain - Bos taurus (Bovine) - CRYAB gene May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Taurus_UMD|evm.model.AC_000172.1.131 Q16082 HSPB2_HUMAN 98.352 0.989071 1.00549 HSPB2 - Heat shock protein beta-2 - Homo sapiens (Human) - HSPB2 gene May regulate the kinase DMPK. Taurus_UMD|evm.model.AC_000172.1.132 Q96A22 CK052_HUMAN 63.158 0.985075 1.08943 C11orf52 - Uncharacterized protein C11orf52 - Homo sapiens (Human) - C11orf52 gene extracellular exosome Taurus_UMD|evm.model.AC_000172.1.133 Q155Q3 DIXC1_HUMAN 93.213 0.969253 1 DIXDC1 - Dixin - Homo sapiens (Human) - DIXDC1 gene Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. Taurus_UMD|evm.model.AC_000172.1.134 P10515 ODP2_HUMAN 89.645 0.996914 1.00155 DLAT - Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor - Homo sapiens (Human) - DLAT gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Taurus_UMD|evm.model.AC_000172.1.135 Q32LH3 PIHD2_BOVIN 99.683 0.993671 1.00317 PIH1D2 - PIH1 domain-containing protein 2 - Bos taurus (Bovine) - PIH1D2 gene Taurus_UMD|evm.model.AC_000172.1.136 Q6ZUT1 NKAP1_HUMAN 92.808 0.993151 1 NKAPD1 - Uncharacterized protein NKAPD1 - Homo sapiens (Human) - NKAPD1 gene identical protein binding Taurus_UMD|evm.model.AC_000172.1.137 Q3SZ93 TIM8B_BOVIN 100.000 0.97619 1.01205 TIMM8B - Mitochondrial import inner membrane translocase subunit Tim8 B - Bos taurus (Bovine) - TIMM8B gene Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). Taurus_UMD|evm.model.AC_000172.1.138 Q95123 DHSD_BOVIN 100.000 0.975 1.01266 SDHD - Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor - Bos taurus (Bovine) - SDHD gene Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Taurus_UMD|evm.model.AC_000172.1.139 O43313 ATMIN_HUMAN 81.935 0.699074 0.262454 ATMIN - ATM interactor - Homo sapiens (Human) - ATMIN gene Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. Taurus_UMD|evm.model.AC_000172.1.140 Q9TU73 IL18_BOVIN 100.000 0.659794 1.50777 IL18 - Interleukin-18 precursor - Bos taurus (Bovine) - IL18 gene A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Taurus_UMD|evm.model.AC_000172.1.141 Q8HXG8 BCDO2_MACFA 81.115 0.956597 1.03597 BCO2 - Beta,beta-carotene 9',10'-oxygenase - Macaca fascicularis (Crab-eating macaque) - BCO2 gene Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects (By similarity). Taurus_UMD|evm.model.AC_000172.1.142 Q9R1Z7 PTPS_MOUSE 90.625 0.869863 1.01389 Pts - 6-pyruvoyl tetrahydrobiopterin synthase - Mus musculus (Mouse) - Pts gene Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. Taurus_UMD|evm.model.AC_000172.1.143 A5D7U1 PLET1_BOVIN 100.000 0.99177 1.00413 PLET1 - Placenta-expressed transcript 1 protein precursor - Bos taurus (Bovine) - PLET1 gene Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity). Taurus_UMD|evm.model.AC_000172.1.144 Q53H47 SETMR_HUMAN 77.966 0.920635 0.0921053 SETMAR - Histone-lysine N-methyltransferase SETMAR - Homo sapiens (Human) - SETMAR gene Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750). Taurus_UMD|evm.model.AC_000172.1.148 P31836 NCAM1_BOVIN 98.533 0.725719 1.30363 NCAM1 - Neural cell adhesion molecule 1 precursor - Bos taurus (Bovine) - NCAM1 gene This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Taurus_UMD|evm.model.AC_000172.1.149 Q9H892 TTC12_HUMAN 81.027 0.991501 1.00142 TTC12 - Tetratricopeptide repeat protein 12 - Homo sapiens (Human) - TTC12 gene Cytoplasmic protein that plays a role in the proper assembly of dynein arm complexes in motile cilia in both respiratory cells and sperm flagella. Taurus_UMD|evm.model.AC_000172.1.150 Q8NFD2 ANKK1_HUMAN 66.946 0.908397 0.342484 ANKK1 - Ankyrin repeat and protein kinase domain-containing protein 1 - Homo sapiens (Human) - ANKK1 gene nucleus, regulation of cell cycle process Taurus_UMD|evm.model.AC_000172.1.151 Q8NFD2 ANKK1_HUMAN 69.154 0.983099 0.464052 ANKK1 - Ankyrin repeat and protein kinase domain-containing protein 1 - Homo sapiens (Human) - ANKK1 gene nucleus, regulation of cell cycle process Taurus_UMD|evm.model.AC_000172.1.152 P20288 DRD2_BOVIN 99.099 0.995495 1 DRD2 - D(2) dopamine receptor - Bos taurus (Bovine) - DRD2 gene Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). Taurus_UMD|evm.model.AC_000172.1.153 Q9H3S3 TMPS5_HUMAN 82.899 0.870886 0.864333 TMPRSS5 - Transmembrane protease serine 5 - Homo sapiens (Human) - TMPRSS5 gene May play a role in hearing. Taurus_UMD|evm.model.AC_000172.1.154 O43264 ZW10_HUMAN 90.886 0.997436 1.00128 ZW10 - Centromere/kinetochore protein zw10 homolog - Homo sapiens (Human) - ZW10 gene Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). Taurus_UMD|evm.model.AC_000172.1.155 C9JDP6 CLD25_HUMAN 81.304 0.991342 1.00873 CLDN25 - Putative claudin-25 - Homo sapiens (Human) - CLDN25 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Taurus_UMD|evm.model.AC_000172.1.156 Q5I043 UBP28_MOUSE 91.582 0.258741 1.08849 Usp28 - Ubiquitin carboxyl-terminal hydrolase 28 - Mus musculus (Mouse) - Usp28 gene Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBXW7) complex. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells. Taurus_UMD|evm.model.AC_000172.1.157 O95264 5HT3B_HUMAN 76.147 0.995261 0.956916 HTR3B - 5-hydroxytryptamine receptor 3B precursor - Homo sapiens (Human) - HTR3B gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Taurus_UMD|evm.model.AC_000172.1.158 P46098 5HT3A_HUMAN 87.041 0.952577 1.01464 HTR3A - 5-hydroxytryptamine receptor 3A precursor - Homo sapiens (Human) - HTR3A gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Taurus_UMD|evm.model.AC_000172.1.159 Q05516 ZBT16_HUMAN 96.137 0.997033 1.00149 ZBTB16 - Zinc finger and BTB domain-containing protein 16 - Homo sapiens (Human) - ZBTB16 gene Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566). Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Taurus_UMD|evm.model.AC_000172.1.160 Q06AV1 NNMT_PIG 55.512 0.922794 1.0303 NNMT - Nicotinamide N-methyltransferase - Sus scrofa (Pig) - NNMT gene Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds (By similarity). Taurus_UMD|evm.model.AC_000172.1.161 Q06AV1 NNMT_PIG 66.176 0.489051 0.518939 NNMT - Nicotinamide N-methyltransferase - Sus scrofa (Pig) - NNMT gene Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds (By similarity). Taurus_UMD|evm.model.AC_000172.1.162 Q32L37 CK071_BOVIN 100.000 0.984962 1.00758 Uncharacterized protein C11orf71 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000172.1.163 Q3MHY8 RBM7_BOVIN 100.000 0.992395 1.00382 RBM7 - RNA-binding protein 7 - Bos taurus (Bovine) - RBM7 gene RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs). Participates in several biological processes including DNA damage response (DDR) and stress response. During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome. Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability. Taurus_UMD|evm.model.AC_000172.1.164 A2VE52 ORN_BOVIN 100.000 0.991597 1.00422 REXO2 - Oligoribonuclease, mitochondrial precursor - Bos taurus (Bovine) - REXO2 gene 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily Taurus_UMD|evm.model.AC_000172.1.165 Q99547 MPH6_HUMAN 68.750 0.984848 0.825 MPHOSPH6 - M-phase phosphoprotein 6 - Homo sapiens (Human) - MPHOSPH6 gene RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D. Taurus_UMD|evm.model.AC_000172.1.167 Q6UWF7 NXPE4_HUMAN 77.615 0.957672 1.04228 NXPE4 - NXPE family member 4 precursor - Homo sapiens (Human) - NXPE4 gene extracellular exosome Taurus_UMD|evm.model.AC_000172.1.168 Q96DL1 NXPE2_HUMAN 76.596 0.883562 1.04472 NXPE2 - NXPE family member 2 - Homo sapiens (Human) - NXPE2 gene Taurus_UMD|evm.model.AC_000172.1.172 Q8R5M8 CADM1_MOUSE 98.246 0.995614 1 Cadm1 - Cell adhesion molecule 1 precursor - Mus musculus (Mouse) - Cadm1 gene Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:12202822, PubMed:12799182, PubMed:12826663). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (PubMed:12826663). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). In mast cells, may mediate attachment to and promote communication with nerves (By similarity). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:15158462, PubMed:16605125). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (PubMed:19752223). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (PubMed:24687959). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (PubMed:24687959). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (PubMed:12202822, PubMed:23209303). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (PubMed:15707673). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (PubMed:12606335, PubMed:16612000). Taurus_UMD|evm.model.AC_000172.1.175 Q9BRD0 BUD13_HUMAN 79.601 0.996933 1.05331 BUD13 - BUD13 homolog - Homo sapiens (Human) - BUD13 gene Involved in pre-mRNA splicing as component of the activated spliceosome. Taurus_UMD|evm.model.AC_000172.1.176 Q2TBX0 ZPR1_BOVIN 100.000 0.995652 1.00218 ZNF259 - Zinc finger protein ZPR1 - Bos taurus (Bovine) - ZNF259 gene Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death (By similarity). Taurus_UMD|evm.model.AC_000172.1.177 P0DSO9 APOA5_ACIJB 81.089 0.937669 0.997297 APOA5 - Apolipoprotein A-V precursor - Acinonyx jubatus (Cheetah) - APOA5 gene Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL (By similarity). May also be associated with chylomicrons (By similarity). Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (By similarity). Binds heparin (By similarity). Taurus_UMD|evm.model.AC_000172.1.178 Q32PJ2 APOA4_BOVIN 99.737 0.994751 1.00263 APOA4 - Apolipoprotein A-IV precursor - Bos taurus (Bovine) - APOA4 gene May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons (By similarity). Taurus_UMD|evm.model.AC_000172.1.179 P19035 APOC3_BOVIN 100.000 0.698529 1.41667 APOC3 - Apolipoprotein C-III precursor - Bos taurus (Bovine) - APOC3 gene Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners. Taurus_UMD|evm.model.AC_000172.1.180 P15497 APOA1_BOVIN 97.093 0.825243 0.777358 APOA1 - Apolipoprotein A-I precursor - Bos taurus (Bovine) - APOA1 gene Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Taurus_UMD|evm.model.AC_000172.1.181 P19035 APOC3_BOVIN 80.488 0.972973 0.770833 APOC3 - Apolipoprotein C-III precursor - Bos taurus (Bovine) - APOC3 gene Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners. Taurus_UMD|evm.model.AC_000172.1.182 P15497 APOA1_BOVIN 100.000 0.992481 1.00377 APOA1 - Apolipoprotein A-I precursor - Bos taurus (Bovine) - APOA1 gene Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Taurus_UMD|evm.model.AC_000172.1.183 Q6P4S6 SIK3_MOUSE 89.855 0.954512 1.03966 Sik3 - Serine/threonine-protein kinase SIK3 - Mus musculus (Mouse) - Sik3 gene Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor (By similarity). Required for chondrocyte hypertrophy during skeletogenesis (PubMed:22318228). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (By similarity). Prevents HDAC4 translocation to the nucleus (PubMed:22318228). Taurus_UMD|evm.model.AC_000172.1.184 Q5R4G2 PA1B2_PONAB 100.000 0.991304 1.00437 PAFAH1B2 - Platelet-activating factor acetylhydrolase IB subunit alpha2 - Pongo abelii (Sumatran orangutan) - PAFAH1B2 gene Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity). Taurus_UMD|evm.model.AC_000172.1.185 Q8NBJ9 SIDT2_HUMAN 95.689 0.997596 1 SIDT2 - SID1 transmembrane family member 2 precursor - Homo sapiens (Human) - SIDT2 gene Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity). Taurus_UMD|evm.model.AC_000172.1.186 Q9TS87 TAGL_BOVIN 100.000 0.990099 1.00498 TAGLN - Transgelin - Bos taurus (Bovine) - TAGLN gene Actin cross-linking/gelling protein. Taurus_UMD|evm.model.AC_000172.1.187 Q16549 PCSK7_HUMAN 89.327 0.997459 1.00255 PCSK7 - Proprotein convertase subtilisin/kexin type 7 precursor - Homo sapiens (Human) - PCSK7 gene Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway. Taurus_UMD|evm.model.AC_000172.1.189 Q8ND24 RN214_HUMAN 94.460 0.997163 1.00284 RNF214 - RING finger protein 214 - Homo sapiens (Human) - RNF214 gene ubiquitin-protein transferase activity Taurus_UMD|evm.model.AC_000172.1.190 Q2HJ40 BACE1_BOVIN 100.000 0.996016 1.002 BACE1 - Beta-secretase 1 precursor - Bos taurus (Bovine) - BACE1 gene Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (By similarity). Cleaves CHL1 (By similarity). Taurus_UMD|evm.model.AC_000172.1.191 Q9UPV0 CE164_HUMAN 69.887 0.99864 1.00753 CEP164 - Centrosomal protein of 164 kDa - Homo sapiens (Human) - CEP164 gene Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. Taurus_UMD|evm.model.AC_000172.1.192 Q8TD84 DSCL1_HUMAN 94.886 0.970302 1.00049 DSCAML1 - Down syndrome cell adhesion molecule-like protein 1 precursor - Homo sapiens (Human) - DSCAML1 gene Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). Taurus_UMD|evm.model.AC_000172.1.193 Q3MHZ5 FXYD6_BOVIN 100.000 0.979167 1.01053 FXYD6 - FXYD domain-containing ion transport regulator 6 precursor - Bos taurus (Bovine) - FXYD6 gene sodium channel regulator activity, regulation of sodium ion transmembrane transporter activity Taurus_UMD|evm.model.AC_000172.1.194 Q5R893 H2B1_PONAB 92.035 0.957265 0.928571 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000172.1.195 Q9BYE2 TMPSD_HUMAN 84.597 0.759777 0.916382 TMPRSS13 - Transmembrane protease serine 13 - Homo sapiens (Human) - TMPRSS13 gene blood microparticle, integral component of membrane, serine-type endopeptidase activity Taurus_UMD|evm.model.AC_000172.1.196 Q13651 I10R1_HUMAN 68.728 0.967298 1.00519 IL10RA - Interleukin-10 receptor subunit alpha precursor - Homo sapiens (Human) - IL10RA gene Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683). Taurus_UMD|evm.model.AC_000172.1.197 A0A1B0GVV1 SIM35_HUMAN 91.566 0.863158 1.11765 SMIM35 - Small integral membrane protein 35 - Homo sapiens (Human) - SMIM35 gene Taurus_UMD|evm.model.AC_000172.1.198 Q9NRS4 TMPS4_HUMAN 77.465 0.894737 1.08696 TMPRSS4 - Transmembrane protease serine 4 - Homo sapiens (Human) - TMPRSS4 gene Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (PubMed:24434139). Seems to be capable of activating ENaC (By similarity). Taurus_UMD|evm.model.AC_000172.1.199 Q08E08 SCN4B_BOVIN 100.000 0.991266 1.00439 SCN4B - Sodium channel subunit beta-4 precursor - Bos taurus (Bovine) - SCN4B gene Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity). Taurus_UMD|evm.model.AC_000172.1.200 O60939 SCN2B_HUMAN 94.884 0.990741 1.00465 SCN2B - Sodium channel subunit beta-2 precursor - Homo sapiens (Human) - SCN2B gene Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). Taurus_UMD|evm.model.AC_000172.1.201 Q86YT9 JAML_HUMAN 67.342 0.994805 0.977157 JAML - Junctional adhesion molecule-like precursor - Homo sapiens (Human) - JAML gene Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. Taurus_UMD|evm.model.AC_000172.1.202 A5D7C3 MPZL3_BOVIN 99.573 0.991489 1.00427 MPZL3 - Myelin protein zero-like protein 3 precursor - Bos taurus (Bovine) - MPZL3 gene Mediates homophilic cell-cell adhesion. Taurus_UMD|evm.model.AC_000172.1.203 Q5EAB0 MPZL2_BOVIN 100.000 0.990741 1.00465 MPZL2 - Myelin protein zero-like protein 2 precursor - Bos taurus (Bovine) - MPZL2 gene Mediates homophilic cell-cell adhesion. Taurus_UMD|evm.model.AC_000172.1.204 Q28073 CD3E_BOVIN 100.000 0.989637 1.00521 CD3E - T-cell surface glycoprotein CD3 epsilon chain precursor - Bos taurus (Bovine) - CD3E gene Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region. Taurus_UMD|evm.model.AC_000172.1.205 Q28072 CD3D_BOVIN 100.000 0.988166 1.00595 CD3D - T-cell surface glycoprotein CD3 delta chain precursor - Bos taurus (Bovine) - CD3D gene Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells. Taurus_UMD|evm.model.AC_000172.1.206 Q28074 CD3G_BOVIN 100.000 0.977273 1.01734 CD3G - T-cell surface glycoprotein CD3 gamma chain precursor - Bos taurus (Bovine) - CD3G gene Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G. Taurus_UMD|evm.model.AC_000172.1.207 A5PKG6 UBE4A_BOVIN 100.000 0.998127 1.00094 UBE4A - Ubiquitin conjugation factor E4 A - Bos taurus (Bovine) - UBE4A gene Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. Taurus_UMD|evm.model.AC_000172.1.208 Q28852 ATP5L_BOVIN 99.029 0.980769 1.00971 ATP5MG - ATP synthase subunit g, mitochondrial - Bos taurus (Bovine) - ATP5MG gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Taurus_UMD|evm.model.AC_000172.1.209 Q5EA92 AL14E_BOVIN 60.000 0.479675 0.473077 ARL14EP - ARL14 effector protein - Bos taurus (Bovine) - ARL14EP gene Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. Taurus_UMD|evm.model.AC_000172.1.210 Q03164 KMT2A_HUMAN 94.539 0.998171 0.964223 KMT2A - Histone-lysine N-methyltransferase 2A - Homo sapiens (Human) - KMT2A gene Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). Taurus_UMD|evm.model.AC_000172.1.211 Q3SZV0 TTC36_BOVIN 100.000 0.989418 1.00532 TTC36 - Tetratricopeptide repeat protein 36 - Bos taurus (Bovine) - TTC36 gene Taurus_UMD|evm.model.AC_000172.1.212 Q86YD3 TMM25_HUMAN 92.896 0.789588 1.25956 TMEM25 - Transmembrane protein 25 precursor - Homo sapiens (Human) - TMEM25 gene In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. Taurus_UMD|evm.model.AC_000172.1.213 Q1LZB4 IFT46_BOVIN 100.000 0.993377 1.00332 IFT46 - Intraflagellar transport protein 46 homolog - Bos taurus (Bovine) - IFT46 gene Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity). Taurus_UMD|evm.model.AC_000172.1.214 P53619 COPD_BOVIN 100.000 0.74359 1.29746 ARCN1 - Coatomer subunit delta - Bos taurus (Bovine) - ARCN1 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). Taurus_UMD|evm.model.AC_000172.1.215 Q63312 PHLB1_RAT 92.298 0.616024 1.59206 Phldb1 - Pleckstrin homology-like domain family B member 1 - Rattus norvegicus (Rat) - Phldb1 gene basal cortex, positive regulation of basement membrane assembly involved in embryonic body morphogenesis, regulation of epithelial to mesenchymal transition, regulation of gastrulation, regulation of microtubule cytoskeleton organization Taurus_UMD|evm.model.AC_000172.1.217 O43280 TREA_HUMAN 82.487 0.982425 0.975986 TREH - Trehalase precursor - Homo sapiens (Human) - TREH gene Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose. Taurus_UMD|evm.model.AC_000172.1.218 P19813 TREA_RABIT 81.159 0.73913 0.15917 TREH - Trehalase precursor - Oryctolagus cuniculus (Rabbit) - TREH gene Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose. Taurus_UMD|evm.model.AC_000172.1.219 P26196 DDX6_HUMAN 99.793 0.993802 1.00207 DDX6 - Probable ATP-dependent RNA helicase DDX6 - Homo sapiens (Human) - DDX6 gene Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). Taurus_UMD|evm.model.AC_000172.1.220 Q04683 CXCR5_MOUSE 86.631 0.994667 1.00267 Cxcr5 - C-X-C chemokine receptor type 5 - Mus musculus (Mouse) - Cxcr5 gene Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. Taurus_UMD|evm.model.AC_000172.1.221 Q86UU0 BCL9L_HUMAN 94.863 0.998663 0.997999 BCL9L - B-cell CLL/lymphoma 9-like protein - Homo sapiens (Human) - BCL9L gene Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). Taurus_UMD|evm.model.AC_000172.1.222 Q08537 UPK2_BOVIN 100.000 0.989247 1.00541 UPK2 - Uroplakin-2 precursor - Bos taurus (Bovine) - UPK2 gene Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM. Taurus_UMD|evm.model.AC_000172.1.223 Q6PIV2 FOXR1_HUMAN 81.164 0.993151 1 FOXR1 - Forkhead box protein R1 - Homo sapiens (Human) - FOXR1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific double-stranded DNA binding Taurus_UMD|evm.model.AC_000172.1.224 Q86UT8 CATAC_HUMAN 89.841 0.865014 1.09337 CENATAC - Centrosomal AT-AC splicing factor - Homo sapiens (Human) - CENATAC gene Negative regulator of centrosome duplication (PubMed:31722219). Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1 (PubMed:31722219). Taurus_UMD|evm.model.AC_000172.1.225 Q6Q311 RS25_SHEEP 100.000 0.984127 1.008 RPS25 - 40S ribosomal protein S25 - Ovis aries (Sheep) - RPS25 gene Taurus_UMD|evm.model.AC_000172.1.226 Q2TBL9 TPPC4_BOVIN 100.000 0.990909 1.00457 TRAPPC4 - Trafficking protein particle complex subunit 4 - Bos taurus (Bovine) - TRAPPC4 gene Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (By similarity). May play a role in dendrite postsynaptic membrane trafficking (By similarity). Taurus_UMD|evm.model.AC_000172.1.227 O43826 G6PT1_HUMAN 95.338 0.995349 1.00233 SLC37A4 - Glucose-6-phosphate exchanger SLC37A4 - Homo sapiens (Human) - SLC37A4 gene Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels. Taurus_UMD|evm.model.AC_000172.1.229 Q9Y4L1 HYOU1_HUMAN 91.517 0.998004 1.003 HYOU1 - Hypoxia up-regulated protein 1 precursor - Homo sapiens (Human) - HYOU1 gene Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. Taurus_UMD|evm.model.AC_000172.1.230 Q9H270 VPS11_HUMAN 96.281 0.997838 0.982997 VPS11 - Vacuolar protein sorting-associated protein 11 homolog - Homo sapiens (Human) - VPS11 gene Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995). Taurus_UMD|evm.model.AC_000172.1.231 Q2KIN5 HEM3_BOVIN 100.000 0.994475 1.00277 HMBS - Porphobilinogen deaminase - Bos taurus (Bovine) - HMBS gene Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Taurus_UMD|evm.model.AC_000172.1.232 P16104 H2AX_HUMAN 99.301 0.986111 1.00699 H2AX - Histone H2AX - Homo sapiens (Human) - H2AX gene Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. Taurus_UMD|evm.model.AC_000172.1.233 Q5EA65 GPT_BOVIN 100.000 0.99511 1.00245 DPAGT1 - UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase - Bos taurus (Bovine) - DPAGT1 gene Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol. Taurus_UMD|evm.model.AC_000172.1.234 O14523 C2C2L_HUMAN 92.645 0.997175 1.00283 C2CD2L - Phospholipid transfer protein C2CD2L - Homo sapiens (Human) - C2CD2L gene Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). Taurus_UMD|evm.model.AC_000172.1.235 Q2TBP2 HINFP_BOVIN 99.806 0.996132 1.00194 HINFP - Histone H4 transcription factor - Bos taurus (Bovine) - HINFP gene Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter (By similarity). Taurus_UMD|evm.model.AC_000172.1.236 Q9H172 ABCG4_HUMAN 89.009 0.996909 1.00155 ABCG4 - ATP-binding cassette sub-family G member 4 - Homo sapiens (Human) - ABCG4 gene May be involved in macrophage lipid homeostasis. Taurus_UMD|evm.model.AC_000172.1.237 Q86UT6 NLRX1_HUMAN 91.385 0.997947 0.998974 NLRX1 - NLR family member X1 precursor - Homo sapiens (Human) - NLRX1 gene Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Taurus_UMD|evm.model.AC_000172.1.238 Q86UT5 NHRF4_HUMAN 82.516 0.924901 0.886165 PDZD3 - Na(+)/H(+) exchange regulatory cofactor NHE-RF4 - Homo sapiens (Human) - PDZD3 gene Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451). Taurus_UMD|evm.model.AC_000172.1.239 Q0P5D1 CC153_BOVIN 100.000 0.777273 1.07843 CCDC153 - Coiled-coil domain-containing protein 153 - Bos taurus (Bovine) - CCDC153 gene Taurus_UMD|evm.model.AC_000172.1.240 P23092 CBL_MLVCN 98.182 0.370913 2.27436 V-CBL - Transforming protein cbl - Cas-NS-1 murine leukemia virus - V-CBL gene Induces early B-lineage lymphomas. Taurus_UMD|evm.model.AC_000172.1.241 P43121 MUC18_HUMAN 80.650 0.996865 0.987616 MCAM - Cell surface glycoprotein MUC18 precursor - Homo sapiens (Human) - MCAM gene Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. Taurus_UMD|evm.model.AC_000172.1.242 Q9BY78 RNF26_HUMAN 90.762 0.995392 1.00231 RNF26 - E3 ubiquitin-protein ligase RNF26 - Homo sapiens (Human) - RNF26 gene E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud (PubMed:27368102). Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 (PubMed:27368102). Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING (PubMed:25254379). Also required to limit type I interferon response by promoting autophagic degradation of IRF3 (PubMed:25254379). Taurus_UMD|evm.model.AC_000172.1.243 Q9BXJ0 C1QT5_HUMAN 97.119 0.991803 1.00412 C1QTNF5 - Complement C1q tumor necrosis factor-related protein 5 precursor - Homo sapiens (Human) - C1QTNF5 gene cell projection, extracellular space, plasma membrane Taurus_UMD|evm.model.AC_000172.1.244 Q9BY79 MFRP_HUMAN 83.477 0.996546 1 MFRP - Membrane frizzled-related protein - Homo sapiens (Human) - MFRP gene May play a role in eye development. Taurus_UMD|evm.model.AC_000172.1.246 Q2KHV7 UBP2_BOVIN 100.000 0.996705 1.00165 USP2 - Ubiquitin carboxyl-terminal hydrolase 2 - Bos taurus (Bovine) - USP2 gene Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Possesses both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1. Taurus_UMD|evm.model.AC_000172.1.247 O62643 THY1_MACMU 73.913 0.987654 1.00621 THY1 - Thy-1 membrane glycoprotein precursor - Macaca mulatta (Rhesus macaque) - THY1 gene May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. Taurus_UMD|evm.model.AC_000172.1.250 Q9GL76 NECT1_PIG 96.107 0.934741 1.01165 NECTIN1 - Nectin-1 precursor - Sus scrofa (Pig) - NECTIN1 gene Probably involved in cell adhesion. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells. Taurus_UMD|evm.model.AC_000172.1.252 Q8R2Q0 TRI29_MOUSE 85.095 0.875796 1.06985 Trim29 - Tripartite motif-containing protein 29 - Mus musculus (Mouse) - Trim29 gene Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. Taurus_UMD|evm.model.AC_000172.1.253 Q86UD1 OAF_HUMAN 73.984 0.840336 0.871795 OAF - Out at first protein homolog precursor - Homo sapiens (Human) - OAF gene Taurus_UMD|evm.model.AC_000172.1.254 Q9UKI9 PO2F3_HUMAN 93.349 0.995349 0.986239 POU2F3 - POU domain, class 2, transcription factor 3 - Homo sapiens (Human) - POU2F3 gene Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen. Taurus_UMD|evm.model.AC_000172.1.255 Q0VD42 TLCD5_BOVIN 100.000 0.99187 1.00408 TLCD5 - TLC domain-containing protein 5 - Bos taurus (Bovine) - TLCD5 gene Taurus_UMD|evm.model.AC_000172.1.257 Q5IS46 GRIK4_PANTR 100.000 0.443396 0.110879 GRIK4 - Glutamate receptor ionotropic, kainate 4 precursor - Pan troglodytes (Chimpanzee) - GRIK4 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). Taurus_UMD|evm.model.AC_000172.1.258 Q16099 GRIK4_HUMAN 99.424 0.440204 0.822176 GRIK4 - Glutamate receptor ionotropic, kainate 4 precursor - Homo sapiens (Human) - GRIK4 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Taurus_UMD|evm.model.AC_000172.1.259 Q5IS46 GRIK4_PANTR 100.000 0.494662 0.293933 GRIK4 - Glutamate receptor ionotropic, kainate 4 precursor - Pan troglodytes (Chimpanzee) - GRIK4 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). Taurus_UMD|evm.model.AC_000172.1.260 P62890 RL30_RAT 96.522 0.982759 1.0087 Rpl30 - 60S ribosomal protein L30 - Rattus norvegicus (Rat) - Rpl30 gene cytosol, cytosolic large ribosomal subunit, nucleus, polysomal ribosome, postsynaptic density, ribosome, RNA binding, selenocysteine insertion sequence binding, structural constituent of ribosome, antimicrobial humoral immune response mediated by antimicrobial peptide Taurus_UMD|evm.model.AC_000172.1.261 Q3T0W7 ATG12_BOVIN 86.000 0.97 0.714286 ATG12 - Ubiquitin-like protein ATG12 - Bos taurus (Bovine) - ATG12 gene Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus (By similarity). Taurus_UMD|evm.model.AC_000172.1.262 Q5QJ74 TBCEL_HUMAN 99.292 0.995294 1.00236 TBCEL - Tubulin-specific chaperone cofactor E-like protein - Homo sapiens (Human) - TBCEL gene Acts as a regulator of tubulin stability. Taurus_UMD|evm.model.AC_000172.1.263 O08523 TECTA_MOUSE 95.452 0.99907 0.998144 Tecta - Alpha-tectorin precursor - Mus musculus (Mouse) - Tecta gene One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Taurus_UMD|evm.model.AC_000172.1.264 O75845 SC5D_HUMAN 84.615 0.993333 1.00334 SC5D - Lathosterol oxidase - Homo sapiens (Human) - SC5D gene Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol in cholesterol biosynthesis. Taurus_UMD|evm.model.AC_000172.1.265 Q92673 SORL_HUMAN 91.609 0.997217 0.973803 SORL1 - Sortilin-related receptor precursor - Homo sapiens (Human) - SORL1 gene Sorting receptor that directs several proteins to their correct location within the cell (Probable). Along with AP-1 complex, involved Golgi apparatus - endosome sorting (PubMed:17646382). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (PubMed:16174740, PubMed:16407538, PubMed:17855360, PubMed:24523320). May also sort newly produced amyloid-beta peptides to lysosomes for catabolism (PubMed:24523320). Does not affect APP trafficking from the endoplasmic reticulum to Golgi compartments (PubMed:17855360). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling by controlling the intracellular location of its receptor (PubMed:23977241). Sorting receptor for GDNF that promotes GDNF regulated, but not constitutive secretion (PubMed:21994944). Sorting receptor for the GDNF-GFRA1 complex, directing it from the cell surface to endosomes. GDNF is then targeted to lysosomes and degraded, while its receptor GFRA1 recycles back to the cell membrane, resulting in a GDNF clearance pathway. The SORL1-GFRA1 complex further targets RET for endocytosis, but not for degradation, affecting GDNF-induced neurotrophic activities (PubMed:23333276). Sorting receptor for ERBB2/HER2. Regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulating phosphoinositide 3-kinase (PI3K)-dependent ERBB2 signaling. In ERBB2-dependent cancer cells, promotes cell proliferation (PubMed:31138794). Sorting receptor for lipoprotein lipase LPL. Promotes LPL localization to endosomes and later to the lysosomes, leading to degradation of newly synthesized LPL (PubMed:21385844). Potential sorting receptor for APOA5, inducing APOA5 internalization to early endosomes, then to late endosomes, wherefrom a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network (PubMed:18603531). Sorting receptor for the insulin receptor INSR. Promotes recycling of internalized INSR via the Golgi apparatus back to the cell surface, thereby preventing lysosomal INSR catabolism, increasing INSR cell surface expression and strengthening insulin signal reception in adipose tissue. Does not affect INSR internalization (PubMed:27322061). Plays a role in renal ion homeostasis, controlling the phospho-regulation of SLC12A1/NKCC2 by STK39/SPAK kinase and PPP3CB/calcineurin A beta phosphatase, possibly through intracellular sorting of STK39 and PPP3CB (By similarity). Stimulates, via the N-terminal ectodomain, the proliferation and migration of smooth muscle cells, possibly by increasing cell surface expression of the urokinase receptor uPAR/PLAUR. This may promote extracellular matrix proteolysis and hence facilitate cell migration (PubMed:14764453). By acting on the migration of intimal smooth muscle cells, may accelerate intimal thickening following vascular injury (PubMed:14764453). Promotes adhesion of monocytes (PubMed:23486467). Stimulates proliferation and migration of monocytes/macrophages (By similarity). Through its action on intimal smooth muscle cells and macrophages, may accelerate intimal thickening and macrophage foam cell formation in the process of atherosclerosis (By similarity). Regulates hypoxia-enhanced adhesion of hematopoietic stem and progenitor cells to the bone marrow stromal cells via a PLAUR-mediated pathway. This function is mediated by the N-terminal ectodomain (PubMed:23486467). Metabolic regulator, which functions to maintain the adequate balance between lipid storage and oxidation in response to changing environmental conditions, such as temperature and diet. The N-terminal ectodomain negatively regulates adipose tissue energy expenditure, acting through the inhibition the BMP/Smad pathway (By similarity). May regulate signaling by the heterodimeric neurotrophic cytokine CLCF1-CRLF1 bound to the CNTFR receptor by promoting the endocytosis of the tripartite complex CLCF1-CRLF1-CNTFR and lysosomal degradation (PubMed:26858303). May regulate IL6 signaling, decreasing cis signaling, possibly by interfering with IL6-binding to membrane-bound IL6R, while up-regulating trans signaling via soluble IL6R (PubMed:28265003). Taurus_UMD|evm.model.AC_000172.1.268 Q8TF42 UBS3B_HUMAN 97.997 0.996923 1.00154 UBASH3B - Ubiquitin-associated and SH3 domain-containing protein B - Homo sapiens (Human) - UBASH3B gene Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. Taurus_UMD|evm.model.AC_000172.1.269 O95727 CRTAM_HUMAN 75.573 0.994885 0.994911 CRTAM - Cytotoxic and regulatory T-cell molecule precursor - Homo sapiens (Human) - CRTAM gene Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity). Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity). Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity). Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity). By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Taurus_UMD|evm.model.AC_000172.1.270 Q2T9M9 JHY_BOVIN 80.204 0.96 0.937904 JHY - Jhy protein homolog - Bos taurus (Bovine) - JHY gene Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. Taurus_UMD|evm.model.AC_000172.1.271 Q3C1V8 BSH_HUMAN 95.279 0.991416 1 BSX - Brain-specific homeobox protein homolog - Homo sapiens (Human) - BSX gene DNA binding protein that function as transcriptional activator. Is essential for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance (By similarity). Taurus_UMD|evm.model.AC_000172.1.272 Q4R7Y2 RL10_MACFA 86.667 0.266055 0.509346 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000172.1.273 P19120 HSP7C_BOVIN 100.000 0.983333 1.01538 HSPA8 - Heat shock cognate 71 kDa protein - Bos taurus (Bovine) - HSPA8 gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. Interacts with VGF-derived peptide TLQP-21. Taurus_UMD|evm.model.AC_000172.1.274 Q9H6B4 CLMP_HUMAN 90.659 0.970588 1.00268 CLMP - CXADR-like membrane protein precursor - Homo sapiens (Human) - CLMP gene May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development. Taurus_UMD|evm.model.AC_000172.1.276 Q3KR37 ASTRB_HUMAN 97.945 0.821995 1.19512 GRAMD1B - Protein Aster-B - Homo sapiens (Human) - GRAMD1B gene Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). Taurus_UMD|evm.model.AC_000172.1.277 Q2KI11 SCN3B_BOVIN 100.000 0.990741 1.00465 SCN3B - Sodium channel subunit beta-3 precursor - Bos taurus (Bovine) - SCN3B gene Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). Taurus_UMD|evm.model.AC_000172.1.278 O95125 ZN202_HUMAN 87.963 0.996918 1.00154 ZNF202 - Zinc finger protein 202 - Homo sapiens (Human) - ZNF202 gene Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease. Taurus_UMD|evm.model.AC_000172.1.279 P0DSO0 SAA2_PIG 59.302 0.901099 0.705426 SAA2 - Serum amyloid A-2 protein precursor - Sus scrofa (Pig) - SAA2 gene Major acute phase reactant. Taurus_UMD|evm.model.AC_000172.1.280 Q96ER3 SAAL1_HUMAN 90.717 0.995781 1 SAAL1 - Protein SAAL1 - Homo sapiens (Human) - SAAL1 gene Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli. Taurus_UMD|evm.model.AC_000172.1.281 P17752 TPH1_HUMAN 96.396 0.870334 1.1464 TPH1 - Tryptophan 5-hydroxylase 1 - Homo sapiens (Human) - TPH1 gene Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis. Taurus_UMD|evm.model.AC_000172.1.283 P25122 KCNC1_RAT 99.829 0.996587 1.00171 Kcnc1 - Potassium voltage-gated channel subfamily C member 1 - Rattus norvegicus (Rat) - Kcnc1 gene Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10482766, PubMed:14679187). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well (PubMed:10482766, PubMed:14679187). Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons (PubMed:10482766). Taurus_UMD|evm.model.AC_000172.1.284 Q7YS82 MYOD1_BOVIN 99.686 0.99373 1.00314 MYOD1 - Myoblast determination protein 1 - Bos taurus (Bovine) - MYOD1 gene Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). Taurus_UMD|evm.model.AC_000172.1.285 Q6ZRI0 OTOG_HUMAN 85.125 0.986078 1.00684 OTOG - Otogelin precursor - Homo sapiens (Human) - OTOG gene Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity). Taurus_UMD|evm.model.AC_000172.1.286 Q3MHQ0 USH1C_BOVIN 100.000 0.131974 1.69147 USH1C - Harmonin - Bos taurus (Bovine) - USH1C gene Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips (By similarity). Taurus_UMD|evm.model.AC_000172.1.287 Q09428 ABCC8_HUMAN 96.149 0.998738 1.00253 ABCC8 - ATP-binding cassette sub-family C member 8 - Homo sapiens (Human) - ABCC8 gene Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. Taurus_UMD|evm.model.AC_000172.1.288 O02822 KCJ11_RABIT 95.897 0.994859 0.997436 KCNJ11 - ATP-sensitive inward rectifier potassium channel 11 - Oryctolagus cuniculus (Rabbit) - KCNJ11 gene This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity). Taurus_UMD|evm.model.AC_000172.1.289 Q68D85 NR3L1_HUMAN 52.510 0.627792 0.887665 NCR3LG1 - Natural cytotoxicity triggering receptor 3 ligand 1 precursor - Homo sapiens (Human) - NCR3LG1 gene Triggers NCR3-dependent natural killer cell activation. Taurus_UMD|evm.model.AC_000172.1.290 P80303 NUCB2_HUMAN 91.106 0.995192 0.990476 NUCB2 - Nucleobindin-2 precursor - Homo sapiens (Human) - NUCB2 gene Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). Taurus_UMD|evm.model.AC_000172.1.292 P55263 ADK_HUMAN 90.345 0.711443 0.555249 ADK - Adenosine kinase - Homo sapiens (Human) - ADK gene ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. Taurus_UMD|evm.model.AC_000172.1.293 O00443 P3C2A_HUMAN 89.696 0.920895 1.08719 PIK3C2A - Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha - Homo sapiens (Human) - PIK3C2A gene Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). Taurus_UMD|evm.model.AC_000172.1.295 Q6IQ23 PKHA7_HUMAN 92.447 0.833333 1.11329 PLEKHA7 - Pleckstrin homology domain-containing family A member 7 - Homo sapiens (Human) - PLEKHA7 gene Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). Taurus_UMD|evm.model.AC_000172.1.296 Q3MHL8 SMAP_BOVIN 100.000 0.989011 1.00552 SMAP - Small acidic protein - Bos taurus (Bovine) - SMAP gene Taurus_UMD|evm.model.AC_000172.1.301 Q1MX18 INSC_HUMAN 89.749 0.989562 0.827288 INSC - Protein inscuteable homolog - Homo sapiens (Human) - INSC gene May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856). Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity). Taurus_UMD|evm.model.AC_000172.1.302 P01261 CALC_SHEEP 95.105 0.986111 1.00699 CALCA - Calcitonin precursor - Ovis aries (Sheep) - CALCA gene Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Taurus_UMD|evm.model.AC_000172.1.303 Q9N0V5 CALC_HORSE 61.475 0.748428 1.13571 CALCA - Calcitonin precursor - Equus caballus (Horse) - CALCA gene Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Taurus_UMD|evm.model.AC_000172.1.304 P08548 LIN1_NYCCO 62.088 0.563863 0.254762 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Taurus_UMD|evm.model.AC_000172.1.305 Q75V95 CRSP1_BOVIN 100.000 0.420455 1.408 CRSP1 - Calcitonin receptor-stimulating peptide 1 precursor - Bos taurus (Bovine) - CRSP1 gene Stimulates cAMP production in porcine kidney cell line LLC-PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. Taurus_UMD|evm.model.AC_000172.1.306 Q96AX1 VP33A_HUMAN 95.146 0.728571 0.234899 VPS33A - Vacuolar protein sorting-associated protein 33A - Homo sapiens (Human) - VPS33A gene Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770). Taurus_UMD|evm.model.AC_000172.1.307 B3IWF8 CRSP2_CAPHI 58.621 0.493506 1.848 CRSP2 - Calcitonin receptor-stimulating peptide 2 precursor - Capra hircus (Goat) - CRSP2 gene Taurus_UMD|evm.model.AC_000172.1.308 Q6VVX0 CP2R1_HUMAN 93.895 0.944223 1.002 CYP2R1 - Vitamin D 25-hydroxylase precursor - Homo sapiens (Human) - CYP2R1 gene A cytochrome P450 monooxygenase involved in activation of vitamin D precursors. Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D(2) and D(3) (calciol) (PubMed:12867411, PubMed:15465040, PubMed:18511070). Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D(2) (doxercalciferol) and 1alpha-hydroxyvitamin D(3) (alfacalcidol) forming 25-hydroxy derivatives (PubMed:15465040, PubMed:18511070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:12867411, PubMed:15465040, PubMed:18511070). Taurus_UMD|evm.model.AC_000172.1.309 Q13370 PDE3B_HUMAN 85.255 0.993728 1.0036 PDE3B - cGMP-inhibited 3',5'-cyclic phosphodiesterase B - Homo sapiens (Human) - PDE3B gene Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. Taurus_UMD|evm.model.AC_000172.1.310 Q3T0X5 PSA1_BOVIN 100.000 0.992424 1.0038 PSMA1 - Proteasome subunit alpha type-1 - Bos taurus (Bovine) - PSMA1 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Taurus_UMD|evm.model.AC_000172.1.311 A0JN39 COPB_BOVIN 100.000 0.997904 1.00105 COPB1 - Coatomer subunit beta - Bos taurus (Bovine) - COPB1 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Involved in the Golgi disassembly and reassembly processes during cell cycle. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Taurus_UMD|evm.model.AC_000172.1.313 O46414 FRIH_BOVIN 97.238 0.989011 1.00552 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000172.1.314 P62071 RRAS2_MOUSE 100.000 0.990244 1.0049 Rras2 - Ras-related protein R-Ras2 precursor - Mus musculus (Mouse) - Rras2 gene GTP-binding protein with GTPase activity involved in the regulation of MAPK signaling pathway, thereby controlling multiple cellular processes. Involved in the regulation of MAPK signaling pathway. Regulation of craniofacial development. Taurus_UMD|evm.model.AC_000172.1.315 Q9GLX9 SPON1_BOVIN 100.000 0.997525 1.00124 SPON1 - Spondin-1 precursor - Bos taurus (Bovine) - SPON1 gene Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell. Taurus_UMD|evm.model.AC_000172.1.316 Q5R834 FACR1_PONAB 98.447 0.996124 1.00194 FAR1 - Fatty acyl-CoA reductase 1 - Pongo abelii (Sumatran orangutan) - FAR1 gene Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis. Taurus_UMD|evm.model.AC_000172.1.317 P01268 PTHY_BOVIN 100.000 0.590674 1.67826 PTH - Parathyroid hormone precursor - Bos taurus (Bovine) - PTH gene PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). Taurus_UMD|evm.model.AC_000172.1.318 Q80X66 BTBDA_MOUSE 97.895 0.995798 1.00211 Btbd10 - BTB/POZ domain-containing protein 10 - Mus musculus (Mouse) - Btbd10 gene Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells. Taurus_UMD|evm.model.AC_000172.1.319 A0MLS5 BMAL1_HORSE 98.722 0.99681 1.0016 ARNTL - Aryl hydrocarbon receptor nuclear translocator-like protein 1 - Equus caballus (Horse) - ARNTL gene Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence. CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3'. The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3'. Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1. Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity). Taurus_UMD|evm.model.AC_000172.1.320 A6NK89 RASFA_HUMAN 86.693 0.996094 1.00986 RASSF10 - Ras association domain-containing protein 10 - Homo sapiens (Human) - RASSF10 gene Plays an important role in regulating embryonic neurogenesis. Taurus_UMD|evm.model.AC_000172.1.321 P28347 TEAD1_HUMAN 94.266 0.995423 1.02582 TEAD1 - Transcriptional enhancer factor TEF-1 - Homo sapiens (Human) - TEAD1 gene Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. Taurus_UMD|evm.model.AC_000172.1.323 Q9NVD7 PARVA_HUMAN 88.079 0.860841 0.830645 PARVA - Alpha-parvin - Homo sapiens (Human) - PARVA gene Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Taurus_UMD|evm.model.AC_000172.1.324 Q9Y6A5 TACC3_HUMAN 69.128 0.746193 0.235084 TACC3 - Transforming acidic coiled-coil-containing protein 3 - Homo sapiens (Human) - TACC3 gene Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). Taurus_UMD|evm.model.AC_000172.1.325 Q9HB97 PARVA_RAT 100.000 0.637681 0.185484 Parva - Alpha-parvin - Rattus norvegicus (Rat) - Parva gene Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Taurus_UMD|evm.model.AC_000172.1.326 Q6ZW33 MICLK_HUMAN 67.054 0.778416 1.25324 MICALCL - MICAL C-terminal-like protein - Homo sapiens (Human) - MICALCL gene May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa. May act as Rab effector protein and play a role in vesicle trafficking. Taurus_UMD|evm.model.AC_000172.1.327 F1MF74 MICA2_BOVIN 100.000 0.998185 1.00091 MICAL2 - [F-actin]-monooxygenase MICAL2 - Bos taurus (Bovine) - MICAL2 gene Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (By similarity). Taurus_UMD|evm.model.AC_000172.1.329 Q9UBP4 DKK3_HUMAN 71.160 0.886598 0.831429 DKK3 - Dickkopf-related protein 3 precursor - Homo sapiens (Human) - DKK3 gene Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). Taurus_UMD|evm.model.AC_000172.1.330 Q96K76 UBP47_HUMAN 96.073 0.998525 0.986182 USP47 - Ubiquitin carboxyl-terminal hydrolase 47 - Homo sapiens (Human) - USP47 gene Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. Taurus_UMD|evm.model.AC_000172.1.331 Q2MHN1 FRIL_FELCA 46.512 0.959184 0.56 FTL - Ferritin light chain - Felis catus (Cat) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000172.1.332 Q6P9A2 GLT18_HUMAN 98.188 0.996711 1.00165 GALNT18 - Polypeptide N-acetylgalactosaminyltransferase 18 - Homo sapiens (Human) - GALNT18 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Taurus_UMD|evm.model.AC_000172.1.333 Q148I0 L10K_BOVIN 100.000 0.979798 1.0102 Leydig cell tumor 10 kDa protein homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000172.1.335 A4Z943 ZBED5_BOVIN 100.000 0.997122 1.00144 ZBED5 - Zinc finger BED domain-containing protein 5 - Bos taurus (Bovine) - ZBED5 gene Taurus_UMD|evm.model.AC_000172.1.336 Q5R7J9 IF4G2_PONAB 99.890 0.813285 1.22822 EIF4G2 - Eukaryotic translation initiation factor 4 gamma 2 - Pongo abelii (Sumatran orangutan) - EIF4G2 gene Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases (By similarity). Taurus_UMD|evm.model.AC_000172.1.337 Q6PD62 CTR9_HUMAN 91.731 0.998206 0.950554 CTR9 - RNA polymerase-associated protein CTR9 homolog - Homo sapiens (Human) - CTR9 gene Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). Taurus_UMD|evm.model.AC_000172.1.338 A4FUB7 GIN1_BOVIN 92.514 0.996169 1.04609 GIN1 - Gypsy retrotransposon integrase-like protein 1 - Bos taurus (Bovine) - GIN1 gene Taurus_UMD|evm.model.AC_000172.1.339 Q9N1F0 IRAG1_BOVIN 99.671 0.997809 1.0022 IRAG1 - Inositol 1,4,5-triphosphate receptor associated 1 - Bos taurus (Bovine) - IRAG1 gene Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. Taurus_UMD|evm.model.AC_000172.1.341 Q6UC88 LYVE1_BOVIN 100.000 0.993808 1.00311 LYVE1 - Lymphatic vessel endothelial hyaluronic acid receptor 1 precursor - Bos taurus (Bovine) - LYVE1 gene Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Taurus_UMD|evm.model.AC_000172.1.343 Q32L15 RN141_BOVIN 100.000 0.991342 1.00435 RNF141 - RING finger protein 141 - Bos taurus (Bovine) - RNF141 gene May be involved in spermatogenesis. Taurus_UMD|evm.model.AC_000172.1.344 Q01432 AMPD3_HUMAN 89.439 0.997351 0.984355 AMPD3 - AMP deaminase 3 - Homo sapiens (Human) - AMPD3 gene AMP deaminase plays a critical role in energy metabolism. Taurus_UMD|evm.model.AC_000172.1.345 O62827 ADML_BOVIN 100.000 0.989418 1.00532 ADM - Pro-adrenomedullin precursor - Bos taurus (Bovine) - ADM gene Hypotensive peptide. May function as a hormone in circulation control (By similarity). Taurus_UMD|evm.model.AC_000172.1.346 Q86WG5 MTMRD_HUMAN 97.258 0.998387 0.335316 SBF2 - Myotubularin-related protein 13 - Homo sapiens (Human) - SBF2 gene Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed:20937701, PubMed:25648148). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701, PubMed:25648148). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Acts as an adapter for the phosphatase MTMR2 (By similarity). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (By similarity). Taurus_UMD|evm.model.AC_000172.1.348 P0C1G6 SWP70_BOVIN 99.829 0.996587 1.00171 SWAP70 - Switch-associated protein 70 - Bos taurus (Bovine) - SWAP70 gene Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). Taurus_UMD|evm.model.AC_000172.1.349 Q9NX08 COMD8_HUMAN 77.711 0.982143 0.918033 COMMD8 - COMM domain-containing protein 8 - Homo sapiens (Human) - COMMD8 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Taurus_UMD|evm.model.AC_000172.1.350 P30291 WEE1_HUMAN 96.749 0.996909 1.00155 WEE1 - Wee1-like protein kinase - Homo sapiens (Human) - WEE1 gene Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Taurus_UMD|evm.model.AC_000172.1.351 O95373 IPO7_HUMAN 98.727 0.696721 1.4104 IPO7 - Importin-7 - Homo sapiens (Human) - IPO7 gene Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Taurus_UMD|evm.model.AC_000172.1.352 P62752 RL23A_RAT 69.841 0.710983 1.10897 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000172.1.353 Q5FVN2 TM41B_RAT 92.440 0.993151 1.00344 Tmem41b - Transmembrane protein 41B - Rattus norvegicus (Rat) - Tmem41b gene Required for autophagosome formation (By similarity). Participates in early stages of autophagosome biogenesis at the ER membrane proabably via mobilization of neutral lipids from lipid droplets (By similarity). Required for normal motor neuron development (By similarity). Essential for embryonic development (By similarity). Taurus_UMD|evm.model.AC_000172.1.354 Q1LZG6 CCNB1_BOVIN 86.713 0.959184 0.344262 CCNB1 - G2/mitotic-specific cyclin-B1 - Bos taurus (Bovine) - CCNB1 gene Essential for the control of the cell cycle at the G2/M (mitosis) transition. Taurus_UMD|evm.model.AC_000172.1.355 Q1LZG6 CCNB1_BOVIN 80.272 0.986486 0.346604 CCNB1 - G2/mitotic-specific cyclin-B1 - Bos taurus (Bovine) - CCNB1 gene Essential for the control of the cell cycle at the G2/M (mitosis) transition. Taurus_UMD|evm.model.AC_000172.1.356 Q6IQ26 DEN5A_HUMAN 97.745 0.996124 1.00233 DENND5A - DENN domain-containing protein 5A - Homo sapiens (Human) - DENND5A gene Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). Taurus_UMD|evm.model.AC_000172.1.357 Q9NQ36 SCUB2_HUMAN 89.202 0.998054 1.02903 SCUBE2 - Signal peptide, CUB and EGF-like domain-containing protein 2 precursor - Homo sapiens (Human) - SCUBE2 gene Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687). Taurus_UMD|evm.model.AC_000172.1.358 Q9NQ35 NRIP3_HUMAN 94.561 0.940476 1.04564 NRIP3 - Nuclear receptor-interacting protein 3 - Homo sapiens (Human) - NRIP3 gene Taurus_UMD|evm.model.AC_000172.1.359 Q9NQ34 TMM9B_HUMAN 97.006 0.677551 1.23737 TMEM9B - Transmembrane protein 9B precursor - Homo sapiens (Human) - TMEM9B gene Enhances production of proinflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways. Taurus_UMD|evm.model.AC_000172.1.360 Q17QV3 SUMO3_BOVIN 97.115 0.980952 1.00962 SUMO3 - Small ubiquitin-related modifier 3 precursor - Bos taurus (Bovine) - SUMO3 gene Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity). Taurus_UMD|evm.model.AC_000172.1.361 Q9NQ33 ASCL3_HUMAN 81.111 0.983516 1.01111 ASCL3 - Achaete-scute homolog 3 - Homo sapiens (Human) - ASCL3 gene Transcriptional repressor. Inhibits myogenesis (By similarity). Taurus_UMD|evm.model.AC_000172.1.362 Q9NQ32 CK016_HUMAN 67.091 0.975104 1.03212 C11orf16 - Uncharacterized protein C11orf16 - Homo sapiens (Human) - C11orf16 gene Taurus_UMD|evm.model.AC_000172.1.363 Q9NQ31 AKIP1_HUMAN 73.810 0.990385 0.990476 AKIP1 - A-kinase-interacting protein 1 - Homo sapiens (Human) - AKIP1 gene Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Taurus_UMD|evm.model.AC_000172.1.364 P78524 DEN2B_HUMAN 93.843 0.976784 1.02287 DENND2B - DENN domain-containing protein 2B - Homo sapiens (Human) - DENND2B gene May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). Taurus_UMD|evm.model.AC_000172.1.365 Q56K03 RL27A_BOVIN 100.000 0.986577 1.00676 RPL27A - 60S ribosomal protein L27a - Bos taurus (Bovine) - RPL27A gene cytosolic large ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000172.1.366 Q924W6 TRI66_MOUSE 85.337 0.998396 1.00403 Trim66 - Tripartite motif-containing protein 66 - Mus musculus (Mouse) - Trim66 gene May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association. Taurus_UMD|evm.model.AC_000172.1.367 Q0VD22 STK33_BOVIN 98.901 0.876448 1.06584 STK33 - Serine/threonine-protein kinase 33 - Bos taurus (Bovine) - STK33 gene Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Taurus_UMD|evm.model.AC_000172.1.369 Q0P5B3 RBTN1_BOVIN 100.000 0.854651 1.10256 LMO1 - Rhombotin-1 - Bos taurus (Bovine) - LMO1 gene May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. Taurus_UMD|evm.model.AC_000172.1.370 Q7Z5B4 RIC3_HUMAN 86.179 0.994565 0.99729 RIC3 - Protein RIC-3 precursor - Homo sapiens (Human) - RIC3 gene Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors (PubMed:12821669, PubMed:15504725, PubMed:16120769, PubMed:18691158, PubMed:32204458). May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. Taurus_UMD|evm.model.AC_000172.1.371 P50607 TUB_HUMAN 93.137 0.996071 1.00593 TUB - Tubby protein homolog - Homo sapiens (Human) - TUB gene Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. Taurus_UMD|evm.model.AC_000172.1.372 Q9DCH4 EIF3F_MOUSE 98.566 0.710997 1.0831 Eif3f - Eukaryotic translation initiation factor 3 subunit F - Mus musculus (Mouse) - Eif3f gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Taurus_UMD|evm.model.AC_000172.1.376 Q6BCY4 NB5R2_HUMAN 80.364 0.30011 3.30797 CYB5R2 - NADH-cytochrome b5 reductase 2 - Homo sapiens (Human) - CYB5R2 gene NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1). Taurus_UMD|evm.model.AC_000172.1.377 Q8ND30 LIPB2_HUMAN 85.911 0.947856 0.98516 PPFIBP2 - Liprin-beta-2 - Homo sapiens (Human) - PPFIBP2 gene May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. Taurus_UMD|evm.model.AC_000172.1.378 Q6UWY5 OLFL1_HUMAN 84.328 0.995037 1.00249 OLFML1 - Olfactomedin-like protein 1 precursor - Homo sapiens (Human) - OLFML1 gene Taurus_UMD|evm.model.AC_000172.1.379 Q86SS6 SYT9_HUMAN 97.751 0.997955 0.995927 SYT9 - Synaptotagmin-9 - Homo sapiens (Human) - SYT9 gene May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Taurus_UMD|evm.model.AC_000172.1.380 Q29RT0 RBMX_BOVIN 100.000 0.994962 1.00253 RBMX - RNA-binding motif protein, X chromosome - Bos taurus (Bovine) - RBMX gene RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment (By similarity). Taurus_UMD|evm.model.AC_000172.1.381 Q86W24 NAL14_HUMAN 72.946 0.987952 0.987191 NLRP14 - NACHT, LRR and PYD domains-containing protein 14 - Homo sapiens (Human) - NLRP14 gene May be involved in inflammation and spermatogenesis. Taurus_UMD|evm.model.AC_000172.1.382 Q9UL59 ZN214_HUMAN 79.868 0.89881 1.10891 ZNF214 - Zinc finger protein 214 - Homo sapiens (Human) - ZNF214 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000172.1.383 Q9UL58 ZN215_HUMAN 72.727 0.996219 1.02321 ZNF215 - Zinc finger protein 215 - Homo sapiens (Human) - ZNF215 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000172.1.384 P23270 OL226_RAT 91.597 0.907692 0.397554 Olr226 - Olfactory receptor 226 - Rattus norvegicus (Rat) - Olr226 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.385 Q7Z2Y8 GVIN1_HUMAN 54.747 0.805397 0.504955 GVINP1 - Interferon-induced very large GTPase 1 - Homo sapiens (Human) - GVINP1 gene Taurus_UMD|evm.model.AC_000172.1.386 Q7Z2Y8 GVIN1_HUMAN 71.203 0.99868 0.938068 GVINP1 - Interferon-induced very large GTPase 1 - Homo sapiens (Human) - GVINP1 gene Taurus_UMD|evm.model.AC_000172.1.387 Q9NRX2 RM17_HUMAN 84.146 0.647541 0.697143 MRPL17 - 39S ribosomal protein L17, mitochondrial precursor - Homo sapiens (Human) - MRPL17 gene large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, protein domain specific binding, structural constituent of ribosome, mitochondrial translational elongation, mitochondrial translational termination Taurus_UMD|evm.model.AC_000172.1.388 Q7Z2Y8 GVIN1_HUMAN 67.879 0.966732 0.210983 GVINP1 - Interferon-induced very large GTPase 1 - Homo sapiens (Human) - GVINP1 gene Taurus_UMD|evm.model.AC_000172.1.389 Q7Z2Y8 GVIN1_HUMAN 67.232 0.928382 0.155656 GVINP1 - Interferon-induced very large GTPase 1 - Homo sapiens (Human) - GVINP1 gene Taurus_UMD|evm.model.AC_000172.1.390 Q7Z2Y8 GVIN1_HUMAN 69.368 0.963671 0.215937 GVINP1 - Interferon-induced very large GTPase 1 - Homo sapiens (Human) - GVINP1 gene Taurus_UMD|evm.model.AC_000172.1.391 Q7Z2Y8 GVIN1_HUMAN 72.199 0.983607 0.100743 GVINP1 - Interferon-induced very large GTPase 1 - Homo sapiens (Human) - GVINP1 gene Taurus_UMD|evm.model.AC_000172.1.392 Q3T0L3 RM17_BOVIN 100.000 0.988439 1.00581 MRPL17 - 39S ribosomal protein L17, mitochondrial precursor - Bos taurus (Bovine) - MRPL17 gene large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000172.1.393 Q96JQ0 PCD16_HUMAN 93.754 0.985642 1.01364 DCHS1 - Protocadherin-16 precursor - Homo sapiens (Human) - DCHS1 gene Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). Taurus_UMD|evm.model.AC_000172.1.394 Q0V8B6 TPP1_BOVIN 99.789 0.969262 0.866785 TPP1 - Tripeptidyl-peptidase 1 precursor - Bos taurus (Bovine) - TPP1 gene Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). Taurus_UMD|evm.model.AC_000172.1.395 Q12962 TAF10_HUMAN 95.413 0.990868 1.00459 TAF10 - Transcription initiation factor TFIID subunit 10 - Homo sapiens (Human) - TAF10 gene TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Taurus_UMD|evm.model.AC_000172.1.396 Q3SWY2 ILK_BOVIN 99.336 0.995585 1.00221 ILK - Integrin-linked protein kinase - Bos taurus (Bovine) - ILK gene Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Regulates cell motility by forming a complex with PARVB. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. Taurus_UMD|evm.model.AC_000172.1.397 O43159 RRP8_HUMAN 78.649 0.995633 1.00439 RRP8 - Ribosomal RNA-processing protein 8 - Homo sapiens (Human) - RRP8 gene Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. Taurus_UMD|evm.model.AC_000172.1.398 Q96M86 DNHD1_HUMAN 74.154 0.987608 1.00168 DNHD1 - Dynein heavy chain domain-containing protein 1 - Homo sapiens (Human) - DNHD1 gene dynein complex, extracellular exosome, inner dynein arm, ATP-dependent microtubule motor activity, minus-end-directed, dynein intermediate chain binding, dynein light intermediate chain binding, cilium movement, microtubule-based movement Taurus_UMD|evm.model.AC_000172.1.399 Q3SZW4 T10B_BOVIN 97.436 0.928 1.05932 TIMM10B - Mitochondrial import inner membrane translocase subunit Tim10 B - Bos taurus (Bovine) - TIMM10B gene Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space. Taurus_UMD|evm.model.AC_000172.1.400 Q3ZCL5 ARFP2_BOVIN 100.000 0.994152 1.00293 ARFIP2 - Arfaptin-2 - Bos taurus (Bovine) - ARFIP2 gene Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Participates also in autophagy by regulating the starvation-depdendent trafficking of ATG9A vesicles which deliver the PI4-kinase to the autophagosome initiation site. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG. Taurus_UMD|evm.model.AC_000172.1.401 O75382 TRIM3_HUMAN 99.194 0.997315 1.00134 TRIM3 - Tripartite motif-containing protein 3 - Homo sapiens (Human) - TRIM3 gene Probably involved in vesicular trafficking via its association with the CART complex (PubMed:15772161). The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Taurus_UMD|evm.model.AC_000172.1.402 Q3SZV7 HEMO_BOVIN 100.000 0.995652 1.00218 HPX - Hemopexin precursor - Bos taurus (Bovine) - HPX gene Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. Taurus_UMD|evm.model.AC_000172.1.403 O00213 APBB1_HUMAN 96.197 0.997175 0.997183 APBB1 - Amyloid-beta A4 precursor protein-binding family B member 1 - Homo sapiens (Human) - APBB1 gene Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Taurus_UMD|evm.model.AC_000172.1.404 Q0VD19 ASM_BOVIN 100.000 0.996805 1.0016 SMPD1 - Sphingomyelin phosphodiesterase precursor - Bos taurus (Bovine) - SMPD1 gene Converts sphingomyelin to ceramide. Exists as two enzymatic forms that arise from alternative trafficking of a single protein precursor, one that is targeted to the endolysosomal compartment, whereas the other is released extracellularly. However, in response to various forms of stress, lysosomal exocytosis may represent a major source of the secretory form. Taurus_UMD|evm.model.AC_000172.1.405 Q8NI29 FBX27_HUMAN 43.210 0.963415 0.869258 FBXO27 - F-box only protein 27 - Homo sapiens (Human) - FBXO27 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Taurus_UMD|evm.model.AC_000172.1.406 A4FV37 CAVN3_BOVIN 100.000 0.992337 1.00385 CAVIN3 - Caveolae-associated protein 3 - Bos taurus (Bovine) - CAVIN3 gene Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2. Taurus_UMD|evm.model.AC_000172.1.407 P79266 GASR_BOVIN 99.780 0.995604 1.0022 CCKBR - Gastrin/cholecystokinin type B receptor - Bos taurus (Bovine) - CCKBR gene Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000172.1.408 Q8IV77 CNGA4_HUMAN 94.087 0.996528 1.00174 CNGA4 - Cyclic nucleotide-gated cation channel alpha-4 - Homo sapiens (Human) - CNGA4 gene Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity). Taurus_UMD|evm.model.AC_000172.1.409 A7YY62 F16A2_BOVIN 97.386 0.737098 1.0555 FHIP1B - FHF complex subunit HOOK interacting protein 1B - Bos taurus (Bovine) - FHIP1B gene Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. Taurus_UMD|evm.model.AC_000172.1.410 Q8N5U0 CK042_HUMAN 87.087 0.994012 1.003 C11orf42 - Uncharacterized protein C11orf42 - Homo sapiens (Human) - C11orf42 gene Taurus_UMD|evm.model.AC_000172.1.411 Q6IF63 O52W1_HUMAN 87.736 0.987539 1.00313 OR52W1 - Olfactory receptor 52W1 - Homo sapiens (Human) - OR52W1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.412 Q96RD2 O52B2_HUMAN 88.172 0.989305 0.578947 OR52B2 - Olfactory receptor 52B2 - Homo sapiens (Human) - OR52B2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.413 P62752 RL23A_RAT 70.833 0.94 0.320513 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000172.1.414 Q3T000 YKT6_BOVIN 78.846 0.723404 0.712121 YKT6 - Synaptobrevin homolog YKT6 precursor - Bos taurus (Bovine) - YKT6 gene Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. Taurus_UMD|evm.model.AC_000172.1.415 Q8NGH7 O52L1_HUMAN 86.495 0.974843 0.966565 OR52L1 - Olfactory receptor 52L1 - Homo sapiens (Human) - OR52L1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.416 Q8NGH7 O52L1_HUMAN 86.068 0.952663 1.02736 OR52L1 - Olfactory receptor 52L1 - Homo sapiens (Human) - OR52L1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.417 Q8NGH5 O56A1_HUMAN 84.984 0.990476 0.990566 OR56A1 - Olfactory receptor 56A1 - Homo sapiens (Human) - OR56A1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.418 Q8NGH8 O56A4_HUMAN 81.818 0.915888 0.341853 OR56A4 - Olfactory receptor 56A4 - Homo sapiens (Human) - OR56A4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.419 Q8NGH8 O56A4_HUMAN 93.836 0.606695 0.763578 OR56A4 - Olfactory receptor 56A4 - Homo sapiens (Human) - OR56A4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.420 Q8NGH8 O56A4_HUMAN 91.558 0.987097 0.495208 OR56A4 - Olfactory receptor 56A4 - Homo sapiens (Human) - OR56A4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.421 Q8NGH8 O56A4_HUMAN 65.916 0.984127 1.00639 OR56A4 - Olfactory receptor 56A4 - Homo sapiens (Human) - OR56A4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.422 Q8NH54 O56A3_HUMAN 75.595 0.988024 0.530159 OR56A3 - Olfactory receptor 56A3 - Homo sapiens (Human) - OR56A3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.423 Q8NH54 O56A3_HUMAN 83.721 0.977099 0.415873 OR56A3 - Olfactory receptor 56A3 - Homo sapiens (Human) - OR56A3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.424 Q8NH54 O56A3_HUMAN 83.121 0.990506 1.00317 OR56A3 - Olfactory receptor 56A3 - Homo sapiens (Human) - OR56A3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.425 Q8NH54 O56A3_HUMAN 79.618 0.978125 1.01587 OR56A3 - Olfactory receptor 56A3 - Homo sapiens (Human) - OR56A3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.426 Q8NH54 O56A3_HUMAN 87.580 0.990506 1.00317 OR56A3 - Olfactory receptor 56A3 - Homo sapiens (Human) - OR56A3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.427 Q8NGH8 O56A4_HUMAN 89.137 0.993631 1.00319 OR56A4 - Olfactory receptor 56A4 - Homo sapiens (Human) - OR56A4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.428 Q8NGH9 O52E4_HUMAN 89.644 0.993548 0.99359 OR52E4 - Olfactory receptor 52E4 - Homo sapiens (Human) - OR52E4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.429 Q6IFG1 O52E8_HUMAN 73.810 0.954373 0.829653 OR52E8 - Olfactory receptor 52E8 - Homo sapiens (Human) - OR52E8 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.430 Q6IFG1 O52E8_HUMAN 85.093 0.820513 0.615142 OR52E8 - Olfactory receptor 52E8 - Homo sapiens (Human) - OR52E8 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.431 Q6IFG1 O52E8_HUMAN 72.313 0.974522 0.990536 OR52E8 - Olfactory receptor 52E8 - Homo sapiens (Human) - OR52E8 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.432 Q6IFG1 O52E8_HUMAN 73.871 0.98722 0.987382 OR52E8 - Olfactory receptor 52E8 - Homo sapiens (Human) - OR52E8 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.433 Q8NGI0 O52N2_HUMAN 85.455 0.982036 0.520249 OR52N2 - Olfactory receptor 52N2 - Homo sapiens (Human) - OR52N2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.434 A4FV72 PPIE_BOVIN 98.095 0.981132 0.352159 PPIE - Peptidyl-prolyl cis-trans isomerase E - Bos taurus (Bovine) - PPIE gene Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity. Taurus_UMD|evm.model.AC_000172.1.435 Q8NH53 O52N1_HUMAN 86.555 0.983051 0.36875 OR52N1 - Olfactory receptor 52N1 - Homo sapiens (Human) - OR52N1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.436 Q8NH56 O52N5_HUMAN 86.926 0.979094 0.885802 OR52N5 - Olfactory receptor 52N5 - Homo sapiens (Human) - OR52N5 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.437 Q8NGI0 O52N2_HUMAN 87.560 0.985782 0.657321 OR52N2 - Olfactory receptor 52N2 - Homo sapiens (Human) - OR52N2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.438 Q8NGI0 O52N2_HUMAN 82.266 0.961905 0.654206 OR52N2 - Olfactory receptor 52N2 - Homo sapiens (Human) - OR52N2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.439 A4FV72 PPIE_BOVIN 98.630 0.9 0.265781 PPIE - Peptidyl-prolyl cis-trans isomerase E - Bos taurus (Bovine) - PPIE gene Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity. Taurus_UMD|evm.model.AC_000172.1.440 Q8NH53 O52N1_HUMAN 83.942 0.978417 0.434375 OR52N1 - Olfactory receptor 52N1 - Homo sapiens (Human) - OR52N1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.441 Q8NH56 O52N5_HUMAN 88.800 0.972656 0.790123 OR52N5 - Olfactory receptor 52N5 - Homo sapiens (Human) - OR52N5 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.442 Q8NGI1 O56B2_HUMAN 74.436 0.985075 0.416149 OR56B2P - Putative olfactory receptor 56B2 - Homo sapiens (Human) - OR56B2P gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.443 Q8NGI1 O56B2_HUMAN 81.818 0.99375 0.993789 OR56B2P - Putative olfactory receptor 56B2 - Homo sapiens (Human) - OR56B2P gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.444 Q6WV90 H4_MYTGA 99.029 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000172.1.445 Q8NGI1 O56B2_HUMAN 82.075 0.990625 0.993789 OR56B2P - Putative olfactory receptor 56B2 - Homo sapiens (Human) - OR56B2P gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.446 Q8NGI1 O56B2_HUMAN 83.529 0.988327 0.798137 OR56B2P - Putative olfactory receptor 56B2 - Homo sapiens (Human) - OR56B2P gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.447 Q8NGI1 O56B2_HUMAN 80.255 0.975078 0.996894 OR56B2P - Putative olfactory receptor 56B2 - Homo sapiens (Human) - OR56B2P gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.448 Q8NGI2 O52N4_HUMAN 82.178 0.952607 0.657321 OR52N4 - Olfactory receptor 52N4 - Homo sapiens (Human) - OR52N4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.449 Q8NGI2 O52N4_HUMAN 88.235 0.990244 0.638629 OR52N4 - Olfactory receptor 52N4 - Homo sapiens (Human) - OR52N4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.450 Q8NGI2 O52N4_HUMAN 90.000 0.990521 0.657321 OR52N4 - Olfactory receptor 52N4 - Homo sapiens (Human) - OR52N4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.451 Q8NH57 O52P1_HUMAN 88.852 0.993464 0.953271 OR52P1P - Putative olfactory receptor 52P1 - Homo sapiens (Human) - OR52P1P gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.452 Q8NH57 O52P1_HUMAN 53.741 0.884848 1.02804 OR52P1P - Putative olfactory receptor 52P1 - Homo sapiens (Human) - OR52P1P gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.453 Q8NH57 O52P1_HUMAN 48.611 0.8 0.716511 OR52P1P - Putative olfactory receptor 52P1 - Homo sapiens (Human) - OR52P1P gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.454 Q8NH57 O52P1_HUMAN 52.769 0.93865 1.01558 OR52P1P - Putative olfactory receptor 52P1 - Homo sapiens (Human) - OR52P1P gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.455 A5A6H4 ROA1_PANTR 95.238 0.408696 1.4375 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Pan troglodytes (Chimpanzee) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. Taurus_UMD|evm.model.AC_000172.1.456 Q8NGJ2 O52H1_HUMAN 62.302 0.887097 0.775 OR52H1 - Olfactory receptor 52H1 - Homo sapiens (Human) - OR52H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.457 Q9EPR4 S23A2_MOUSE 54.237 0.915556 0.694444 Slc23a2 - Solute carrier family 23 member 2 - Mus musculus (Mouse) - Slc23a2 gene Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (By similarity). Taurus_UMD|evm.model.AC_000172.1.458 Q07537 GALT1_BOVIN 97.041 0.988235 0.304114 GALNT1 - Polypeptide N-acetylgalactosaminyltransferase 1 - Bos taurus (Bovine) - GALNT1 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. Taurus_UMD|evm.model.AC_000172.1.459 Q07537 GALT1_BOVIN 98.939 0.994709 0.676208 GALNT1 - Polypeptide N-acetylgalactosaminyltransferase 1 - Bos taurus (Bovine) - GALNT1 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. Taurus_UMD|evm.model.AC_000172.1.460 Q9ZRB2 TBB1_WHEAT 100.000 0.8 0.191011 TUBB1 - Tubulin beta-1 chain - Triticum aestivum (Wheat) - TUBB1 gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Taurus_UMD|evm.model.AC_000172.1.461 Q5D7I9 TRIM5_PYGNE 53.488 0.915966 0.480808 TRIM5 - Tripartite motif-containing protein 5 - Pygathrix nemaeus (Red-shanked douc langur) - TRIM5 gene Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2. Taurus_UMD|evm.model.AC_000172.1.462 Q8NGJ2 O52H1_HUMAN 74.026 0.977707 0.98125 OR52H1 - Olfactory receptor 52H1 - Homo sapiens (Human) - OR52H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.463 Q5D7J1 TRIM5_PANTR 62.069 0.9022 0.829615 TRIM5 - Tripartite motif-containing protein 5 - Pan troglodytes (Chimpanzee) - TRIM5 gene Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2. Taurus_UMD|evm.model.AC_000172.1.464 Q5D7I9 TRIM5_PYGNE 63.448 0.71358 0.818182 TRIM5 - Tripartite motif-containing protein 5 - Pygathrix nemaeus (Red-shanked douc langur) - TRIM5 gene Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2. Taurus_UMD|evm.model.AC_000172.1.465 Q5D7J0 TRIM5_COLGU 57.199 0.995968 1.00202 TRIM5 - Tripartite motif-containing protein 5 - Colobus guereza (Mantled guereza) - TRIM5 gene Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2. Taurus_UMD|evm.model.AC_000172.1.466 Q9BYJ4 TRI34_HUMAN 72.245 0.99591 1.00205 TRIM34 - Tripartite motif-containing protein 34 - Homo sapiens (Human) - TRIM34 gene May function as antiviral protein and may contribute to the defense against retroviral infections. Taurus_UMD|evm.model.AC_000172.1.468 Q9C030 TRIM6_HUMAN 83.197 0.791531 1.2582 TRIM6 - Tripartite motif-containing protein 6 - Homo sapiens (Human) - TRIM6 gene E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway (PubMed:24882218, PubMed:31694946). In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response (PubMed:24882218). Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Taurus_UMD|evm.model.AC_000172.1.469 Q8NGF0 O52B6_HUMAN 85.427 0.99 0.597015 OR52B6 - Olfactory receptor 52B6 - Homo sapiens (Human) - OR52B6 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.470 Q8NGF0 O52B6_HUMAN 82.162 0.8 0.686567 OR52B6 - Olfactory receptor 52B6 - Homo sapiens (Human) - OR52B6 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.471 Q8NGJ2 O52H1_HUMAN 69.014 0.971831 0.44375 OR52H1 - Olfactory receptor 52H1 - Homo sapiens (Human) - OR52H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.472 Q8NGJ2 O52H1_HUMAN 80.195 0.983974 0.975 OR52H1 - Olfactory receptor 52H1 - Homo sapiens (Human) - OR52H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.473 Q8NGJ2 O52H1_HUMAN 89.355 0.980952 0.984375 OR52H1 - Olfactory receptor 52H1 - Homo sapiens (Human) - OR52H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.474 Q8NGJ2 O52H1_HUMAN 88.811 0.577236 0.76875 OR52H1 - Olfactory receptor 52H1 - Homo sapiens (Human) - OR52H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.475 Q8IYU4 UBQLN_HUMAN 68.842 0.38206 2.53474 UBQLNL - Ubiquilin-like protein - Homo sapiens (Human) - UBQLNL gene cytosol, polyubiquitin modification-dependent protein binding, ubiquitin-dependent protein catabolic process Taurus_UMD|evm.model.AC_000172.1.476 Q9H347 UBQL3_HUMAN 79.116 0.995434 1.00305 UBQLN3 - Ubiquilin-3 - Homo sapiens (Human) - UBQLN3 gene cytosol, polyubiquitin modification-dependent protein binding, ubiquitin-dependent protein catabolic process Taurus_UMD|evm.model.AC_000172.1.477 Q9UHD9 UBQL2_HUMAN 57.971 0.128846 0.833333 UBQLN2 - Ubiquilin-2 - Homo sapiens (Human) - UBQLN2 gene Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683). Taurus_UMD|evm.model.AC_000172.1.478 Q9H346 O52D1_HUMAN 87.421 0.99373 1.00314 OR52D1 - Olfactory receptor 52D1 - Homo sapiens (Human) - OR52D1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.479 Q9H346 O52D1_HUMAN 85.535 0.99373 1.00314 OR52D1 - Olfactory receptor 52D1 - Homo sapiens (Human) - OR52D1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.480 Q9H346 O52D1_HUMAN 85.220 0.99373 1.00314 OR52D1 - Olfactory receptor 52D1 - Homo sapiens (Human) - OR52D1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.481 Q9H344 O51I2_HUMAN 63.710 0.242604 1.625 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.482 Q9H344 O51I2_HUMAN 63.200 0.438163 0.907051 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.483 Q9H344 O51I2_HUMAN 63.584 0.747826 0.737179 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.484 Q9H344 O51I2_HUMAN 89.103 0.99361 1.00321 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.485 Q9H344 O51I2_HUMAN 88.189 0.992157 0.817308 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.486 Q9H343 O51I1_HUMAN 86.538 0.987261 1 OR51I1 - Olfactory receptor 51I1 - Homo sapiens (Human) - OR51I1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.487 Q9H344 O51I2_HUMAN 56.897 0.911672 1.01603 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.488 Q8NH59 O51Q1_HUMAN 80.126 0.972308 1.02524 OR51Q1 - Olfactory receptor 51Q1 - Homo sapiens (Human) - OR51Q1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.489 Q8NH59 O51Q1_HUMAN 82.222 0.247191 0.561514 OR51Q1 - Olfactory receptor 51Q1 - Homo sapiens (Human) - OR51Q1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.490 Q9H342 O51J1_HUMAN 59.215 0.993711 1.00633 OR51J1 - Olfactory receptor 51J1 - Homo sapiens (Human) - OR51J1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.491 Q8NGK0 O51G2_HUMAN 56.627 0.976378 0.808917 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.492 Q9Y5P1 O51B2_HUMAN 43.005 0.949153 0.567308 OR51B2 - Olfactory receptor 51B2 - Homo sapiens (Human) - OR51B2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.493 Q9H341 O51M1_HUMAN 83.750 0.993769 0.984663 OR51M1 - Olfactory receptor 51M1 - Homo sapiens (Human) - OR51M1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.494 Q9H341 O51M1_HUMAN 82.407 0.938596 0.349693 OR51M1 - Olfactory receptor 51M1 - Homo sapiens (Human) - OR51M1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.496 P02102 HBE1_CAPHI 100.000 0.986486 1.0068 HBE1 - Hemoglobin subunit epsilon-1 - Capra hircus (Goat) - HBE1 gene Beta-type chain found in early embryos. Taurus_UMD|evm.model.AC_000172.1.497 P06643 HBE4_BOVIN 100.000 0.55814 1.7551 HBE4 - Hemoglobin subunit epsilon-4 - Bos taurus (Bovine) - HBE4 gene Hemoglobin epsilon chain is a beta-type chain found in early embryos. Taurus_UMD|evm.model.AC_000172.1.498 P02070 HBB_BOVIN 100.000 0.986301 1.0069 HBB - Hemoglobin subunit beta - Bos taurus (Bovine) - HBB gene Involved in oxygen transport from the lung to the various peripheral tissues. Taurus_UMD|evm.model.AC_000172.1.499 P06642 HBE2_BOVIN 100.000 0.358209 2.73469 HBE2 - Hemoglobin subunit epsilon-2 - Bos taurus (Bovine) - HBE2 gene Hemoglobin epsilon chain is a beta-type chain found in early embryos. Taurus_UMD|evm.model.AC_000172.1.500 P02081 HBBF_BOVIN 100.000 0.986301 1.0069 Hemoglobin fetal subunit beta - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000172.1.501 Q9H2C8 O51V1_HUMAN 87.859 0.987302 0.981308 OR51V1 - Olfactory receptor 51V1 - Homo sapiens (Human) - OR51V1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.502 P0C646 O52Z1_HUMAN 84.821 0.414179 0.899329 OR52Z1 - Olfactory receptor 52Z1 - Homo sapiens (Human) - OR52Z1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.503 Q9UKL2 O52A1_HUMAN 82.721 0.978339 0.887821 OR52A1 - Olfactory receptor 52A1 - Homo sapiens (Human) - OR52A1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.504 Q9UKL2 O52A1_HUMAN 83.333 0.99361 1.00321 OR52A1 - Olfactory receptor 52A1 - Homo sapiens (Human) - OR52A1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.505 Q9UKL2 O52A1_HUMAN 83.333 0.981073 1.01603 OR52A1 - Olfactory receptor 52A1 - Homo sapiens (Human) - OR52A1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.506 Q9UKL2 O52A1_HUMAN 80.247 0.629921 0.407051 OR52A1 - Olfactory receptor 52A1 - Homo sapiens (Human) - OR52A1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.507 Q9H2C5 O52A5_HUMAN 84.839 0.968652 1.00949 OR52A5 - Olfactory receptor 52A5 - Homo sapiens (Human) - OR52A5 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.508 P0C646 O52Z1_HUMAN 74.302 0.847619 0.704698 OR52Z1 - Olfactory receptor 52Z1 - Homo sapiens (Human) - OR52Z1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.509 Q9H2C8 O51V1_HUMAN 89.683 0.984314 0.794393 OR51V1 - Olfactory receptor 51V1 - Homo sapiens (Human) - OR51V1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.510 P02081 HBBF_BOVIN 99.138 0.515695 1.53793 Hemoglobin fetal subunit beta - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000172.1.511 Q8NH61 O51F2_HUMAN 64.192 0.978541 0.681287 OR51F2 - Olfactory receptor 51F2 - Homo sapiens (Human) - OR51F2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.512 A6NGY5 O51F1_HUMAN 63.141 0.980952 0.987461 OR51F1 - Olfactory receptor 51F1 - Homo sapiens (Human) - OR51F1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.513 A6NGY5 O51F1_HUMAN 69.231 0.992366 0.821317 OR51F1 - Olfactory receptor 51F1 - Homo sapiens (Human) - OR51F1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.514 A6NGY5 O51F1_HUMAN 65.246 0.967949 0.978056 OR51F1 - Olfactory receptor 51F1 - Homo sapiens (Human) - OR51F1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.515 Q8NGF1 O52R1_HUMAN 81.935 0.968652 1.0127 OR52R1 - Olfactory receptor 52R1 - Homo sapiens (Human) - OR52R1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.516 Q8NGF1 O52R1_HUMAN 69.858 0.54818 1.48254 OR52R1 - Olfactory receptor 52R1 - Homo sapiens (Human) - OR52R1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.517 Q8NGF1 O52R1_HUMAN 81.230 0.965517 1.0127 OR52R1 - Olfactory receptor 52R1 - Homo sapiens (Human) - OR52R1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.518 Q8NH61 O51F2_HUMAN 75.399 0.982517 0.836257 OR51F2 - Olfactory receptor 51F2 - Homo sapiens (Human) - OR51F2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.519 Q8NH64 O51A7_HUMAN 75.410 0.958991 1.01603 OR51A7 - Olfactory receptor 51A7 - Homo sapiens (Human) - OR51A7 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.520 Q8NGJ8 O51S1_HUMAN 81.056 0.993808 1 OR51S1 - Olfactory receptor 51S1 - Homo sapiens (Human) - OR51S1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.521 Q8NH63 O51H1_HUMAN 60.596 0.940439 1.05629 OR51H1 - Olfactory receptor 51H1 - Homo sapiens (Human) - OR51H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.522 Q8NH63 O51H1_HUMAN 80.087 0.858209 0.887417 OR51H1 - Olfactory receptor 51H1 - Homo sapiens (Human) - OR51H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.523 Q8NH63 O51H1_HUMAN 62.069 0.942149 0.400662 OR51H1 - Olfactory receptor 51H1 - Homo sapiens (Human) - OR51H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.524 Q8NGJ9 O51T1_HUMAN 77.676 0.993902 1.00306 OR51T1 - Olfactory receptor 51T1 - Homo sapiens (Human) - OR51T1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.525 Q8NGF1 O52R1_HUMAN 78.947 0.607843 0.485714 OR52R1 - Olfactory receptor 52R1 - Homo sapiens (Human) - OR52R1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.526 Q8NH61 O51F2_HUMAN 88.179 0.984227 0.926901 OR51F2 - Olfactory receptor 51F2 - Homo sapiens (Human) - OR51F2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.527 Q8NGJ8 O51S1_HUMAN 83.062 0.993506 0.95356 OR51S1 - Olfactory receptor 51S1 - Homo sapiens (Human) - OR51S1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.528 Q8NH63 O51H1_HUMAN 60.927 0.940439 1.05629 OR51H1 - Olfactory receptor 51H1 - Homo sapiens (Human) - OR51H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.529 Q8NH63 O51H1_HUMAN 79.139 0.946372 1.04967 OR51H1 - Olfactory receptor 51H1 - Homo sapiens (Human) - OR51H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.530 Q8NH63 O51H1_HUMAN 55.357 0.893048 0.619205 OR51H1 - Olfactory receptor 51H1 - Homo sapiens (Human) - OR51H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.531 Q8NGJ9 O51T1_HUMAN 77.370 0.993902 1.00306 OR51T1 - Olfactory receptor 51T1 - Homo sapiens (Human) - OR51T1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.532 Q8NH64 O51A7_HUMAN 76.316 0.317797 0.75641 OR51A7 - Olfactory receptor 51A7 - Homo sapiens (Human) - OR51A7 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.533 Q8NGK0 O51G2_HUMAN 90.970 0.949045 1 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.534 Q8NGK1 O51G1_HUMAN 96.850 0.782609 0.501558 OR51G1 - Olfactory receptor 51G1 - Homo sapiens (Human) - OR51G1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.535 Q8NGK3 O52K2_HUMAN 54.000 0.846416 0.933121 OR52K2 - Olfactory receptor 52K2 - Homo sapiens (Human) - OR52K2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.536 Q8NGJ4 O52E2_HUMAN 87.500 0.984496 0.396923 OR52E2 - Olfactory receptor 52E2 - Homo sapiens (Human) - OR52E2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.537 Q8NGH9 O52E4_HUMAN 70.833 0.971875 1.02564 OR52E4 - Olfactory receptor 52E4 - Homo sapiens (Human) - OR52E4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.538 Q8NGJ4 O52E2_HUMAN 74.227 0.827586 0.356923 OR52E2 - Olfactory receptor 52E2 - Homo sapiens (Human) - OR52E2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.540 Q8NGJ4 O52E2_HUMAN 85.075 0.977941 0.418462 OR52E2 - Olfactory receptor 52E2 - Homo sapiens (Human) - OR52E2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.541 Q8NGJ3 O52E1_HUMAN 82.812 0.979487 0.633117 OR52E1 - Olfactory receptor 52E1 - Homo sapiens (Human) - OR52E1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.542 Q8NGK3 O52K2_HUMAN 53.600 0.846416 0.933121 OR52K2 - Olfactory receptor 52K2 - Homo sapiens (Human) - OR52K2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.543 Q9H2C5 O52A5_HUMAN 60.547 0.972763 0.813291 OR52A5 - Olfactory receptor 52A5 - Homo sapiens (Human) - OR52A5 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.544 Q9H2C5 O52A5_HUMAN 48.221 0.972603 0.693038 OR52A5 - Olfactory receptor 52A5 - Homo sapiens (Human) - OR52A5 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.545 Q8NGK3 O52K2_HUMAN 56.410 0.0885781 1.36624 OR52K2 - Olfactory receptor 52K2 - Homo sapiens (Human) - OR52K2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.546 Q9UKL2 O52A1_HUMAN 58.703 0.941558 0.987179 OR52A1 - Olfactory receptor 52A1 - Homo sapiens (Human) - OR52A1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.547 Q8NH57 O52P1_HUMAN 65.517 0.777027 0.461059 OR52P1P - Putative olfactory receptor 52P1 - Homo sapiens (Human) - OR52P1P gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.549 Q9UKL2 O52A1_HUMAN 83.654 0.99361 1.00321 OR52A1 - Olfactory receptor 52A1 - Homo sapiens (Human) - OR52A1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.550 Q9H2C5 O52A5_HUMAN 83.077 0.97 0.632911 OR52A5 - Olfactory receptor 52A5 - Homo sapiens (Human) - OR52A5 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.551 Q9H2C8 O51V1_HUMAN 76.948 0.977707 0.978193 OR51V1 - Olfactory receptor 51V1 - Homo sapiens (Human) - OR51V1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.552 Q8NH57 O52P1_HUMAN 58.929 0.922652 0.563863 OR52P1P - Putative olfactory receptor 52P1 - Homo sapiens (Human) - OR52P1P gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.553 Q8NH57 O52P1_HUMAN 59.524 0.938202 0.554517 OR52P1P - Putative olfactory receptor 52P1 - Homo sapiens (Human) - OR52P1P gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.554 Q9H2C5 O52A5_HUMAN 78.165 0.993691 1.00316 OR52A5 - Olfactory receptor 52A5 - Homo sapiens (Human) - OR52A5 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.555 Q9H2C8 O51V1_HUMAN 73.312 0.987261 0.978193 OR51V1 - Olfactory receptor 51V1 - Homo sapiens (Human) - OR51V1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.556 Q9H2C8 O51V1_HUMAN 77.316 0.984227 0.987539 OR51V1 - Olfactory receptor 51V1 - Homo sapiens (Human) - OR51V1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.557 P0C646 O52Z1_HUMAN 73.220 0.970297 1.01678 OR52Z1 - Olfactory receptor 52Z1 - Homo sapiens (Human) - OR52Z1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.558 Q8NH63 O51H1_HUMAN 47.126 0.931655 0.92053 OR51H1 - Olfactory receptor 51H1 - Homo sapiens (Human) - OR51H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.559 Q8NGK0 O51G2_HUMAN 59.722 0.821839 0.55414 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.560 Q8NGK0 O51G2_HUMAN 55.631 0.924051 1.00637 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.561 Q8NGK0 O51G2_HUMAN 62.081 0.931034 1.01592 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.562 Q8NGK0 O51G2_HUMAN 56.863 0.834711 0.38535 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.563 Q8NH57 O52P1_HUMAN 58.025 0.858156 0.878505 OR52P1P - Putative olfactory receptor 52P1 - Homo sapiens (Human) - OR52P1P gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.564 Q9H2C5 O52A5_HUMAN 59.615 0.987097 0.981013 OR52A5 - Olfactory receptor 52A5 - Homo sapiens (Human) - OR52A5 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.565 Q8NGK5 O52M1_HUMAN 55.034 0.891566 1.04732 OR52M1 - Olfactory receptor 52M1 - Homo sapiens (Human) - OR52M1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.566 Q9H346 O52D1_HUMAN 54.074 0.956835 0.437107 OR52D1 - Olfactory receptor 52D1 - Homo sapiens (Human) - OR52D1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.567 Q8NGK4 O52K1_HUMAN 50.323 0.980952 1.00318 OR52K1 - Olfactory receptor 52K1 - Homo sapiens (Human) - OR52K1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.568 Q9H2C5 O52A5_HUMAN 57.595 0.971787 1.00949 OR52A5 - Olfactory receptor 52A5 - Homo sapiens (Human) - OR52A5 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.569 Q8NH60 O52J3_HUMAN 87.781 0.99359 1.00322 OR52J3 - Olfactory receptor 52J3 - Homo sapiens (Human) - OR52J3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.570 Q8NGJ3 O52E1_HUMAN 83.660 0.540925 0.912338 OR52E1 - Olfactory receptor 52E1 - Homo sapiens (Human) - OR52E1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.571 Q8NGJ4 O52E2_HUMAN 79.352 0.825503 0.916923 OR52E2 - Olfactory receptor 52E2 - Homo sapiens (Human) - OR52E2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.572 Q8NGJ3 O52E1_HUMAN 83.333 0.979487 0.633117 OR52E1 - Olfactory receptor 52E1 - Homo sapiens (Human) - OR52E1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.573 Q8NH60 O52J3_HUMAN 92.793 0.769231 0.459807 OR52J3 - Olfactory receptor 52J3 - Homo sapiens (Human) - OR52J3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.574 Q8NH60 O52J3_HUMAN 87.097 0.284065 1.39228 OR52J3 - Olfactory receptor 52J3 - Homo sapiens (Human) - OR52J3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.575 Q8NGK0 O51G2_HUMAN 59.839 0.972549 0.812102 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.576 Q8NGJ5 O51L1_HUMAN 86.538 0.984177 1.00317 OR51L1 - Olfactory receptor 51L1 - Homo sapiens (Human) - OR51L1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.577 Q8NGK1 O51G1_HUMAN 92.614 0.988701 0.551402 OR51G1 - Olfactory receptor 51G1 - Homo sapiens (Human) - OR51G1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.578 Q8NGK0 O51G2_HUMAN 88.963 0.983498 0.964968 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.579 Q8NGJ5 O51L1_HUMAN 84.718 0.916923 1.03175 OR51L1 - Olfactory receptor 51L1 - Homo sapiens (Human) - OR51L1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.580 Q8NGJ6 O51A4_HUMAN 83.706 0.990476 1.00639 OR51A4 - Olfactory receptor 51A4 - Homo sapiens (Human) - OR51A4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.581 Q8NGJ6 O51A4_HUMAN 82.428 0.990476 1.00639 OR51A4 - Olfactory receptor 51A4 - Homo sapiens (Human) - OR51A4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.582 Q8NH64 O51A7_HUMAN 68.608 0.993548 0.99359 OR51A7 - Olfactory receptor 51A7 - Homo sapiens (Human) - OR51A7 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.583 Q8NGJ6 O51A4_HUMAN 84.236 0.990196 0.651757 OR51A4 - Olfactory receptor 51A4 - Homo sapiens (Human) - OR51A4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.584 Q8NH64 O51A7_HUMAN 58.958 0.962264 1.01923 OR51A7 - Olfactory receptor 51A7 - Homo sapiens (Human) - OR51A7 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.585 Q8NGK1 O51G1_HUMAN 85.827 0.766667 0.46729 OR51G1 - Olfactory receptor 51G1 - Homo sapiens (Human) - OR51G1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.586 Q8NH61 O51F2_HUMAN 62.179 0.987302 0.921053 OR51F2 - Olfactory receptor 51F2 - Homo sapiens (Human) - OR51F2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.587 Q8NH61 O51F2_HUMAN 60.000 0.990536 0.926901 OR51F2 - Olfactory receptor 51F2 - Homo sapiens (Human) - OR51F2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.588 Q8NH61 O51F2_HUMAN 63.141 0.987302 0.921053 OR51F2 - Olfactory receptor 51F2 - Homo sapiens (Human) - OR51F2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.589 Q8NH61 O51F2_HUMAN 60.568 0.993651 0.921053 OR51F2 - Olfactory receptor 51F2 - Homo sapiens (Human) - OR51F2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.590 Q9H255 O51E2_HUMAN 91.562 0.993769 1.00313 OR51E2 - Olfactory receptor 51E2 - Homo sapiens (Human) - OR51E2 gene Olfactory receptor (PubMed:29249973, PubMed:27226631). Activated by the odorant, beta-ionone, a synthetic terpenoid (PubMed:29249973, PubMed:27226631, PubMed:19389702). The activity of this receptor is propably mediated by G-proteins leading to the elevation of intracellular Ca(2+), cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (PubMed:27226631, PubMed:29249973). Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (PubMed:27226631). Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (PubMed:29249973). Activated also by the short-chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). Activated by L-lactate in glomus cells (By similarity). Taurus_UMD|evm.model.AC_000172.1.591 Q9H344 O51I2_HUMAN 57.333 0.931464 1.02885 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.592 Q9H344 O51I2_HUMAN 51.667 0.923875 0.926282 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.593 Q9H344 O51I2_HUMAN 58.586 0.922118 1.02885 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.594 Q9H344 O51I2_HUMAN 52.878 0.860248 1.03205 OR51I2 - Olfactory receptor 51I2 - Homo sapiens (Human) - OR51I2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.595 Q8TCB6 O51E1_HUMAN 93.375 0.993711 1.00315 OR51E1 - Olfactory receptor 51E1 - Homo sapiens (Human) - OR51E1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.596 Q8NGF3 O51D1_HUMAN 88.889 0.890052 0.589506 OR51D1 - Olfactory receptor 51D1 - Homo sapiens (Human) - OR51D1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.597 Q6AZZ1 TRI68_HUMAN 88.247 0.995885 1.00206 TRIM68 - E3 ubiquitin-protein ligase TRIM68 - Homo sapiens (Human) - TRIM68 gene Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity. Taurus_UMD|evm.model.AC_000172.1.598 Q8NH67 O52I2_HUMAN 81.667 0.988889 0.514286 OR52I2 - Olfactory receptor 52I2 - Homo sapiens (Human) - OR52I2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.599 Q8NH67 O52I2_HUMAN 80.556 0.98895 0.517143 OR52I2 - Olfactory receptor 52I2 - Homo sapiens (Human) - OR52I2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.600 Q8NH67 O52I2_HUMAN 80.000 0.908629 0.562857 OR52I2 - Olfactory receptor 52I2 - Homo sapiens (Human) - OR52I2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.601 Q8NGJ4 O52E2_HUMAN 81.712 0.988372 0.793846 OR52E2 - Olfactory receptor 52E2 - Homo sapiens (Human) - OR52E2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.603 Q8NGK4 O52K1_HUMAN 89.655 0.990196 0.649682 OR52K1 - Olfactory receptor 52K1 - Homo sapiens (Human) - OR52K1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.604 Q8NGK4 O52K1_HUMAN 93.103 0.990196 0.649682 OR52K1 - Olfactory receptor 52K1 - Homo sapiens (Human) - OR52K1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.605 Q8NGK5 O52M1_HUMAN 85.795 0.988701 0.55836 OR52M1 - Olfactory receptor 52M1 - Homo sapiens (Human) - OR52M1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.606 Q8NGK4 O52K1_HUMAN 86.325 0.983051 0.375796 OR52K1 - Olfactory receptor 52K1 - Homo sapiens (Human) - OR52K1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.607 Q8NGK0 O51G2_HUMAN 53.356 0.933962 1.01274 OR51G2 - Olfactory receptor 51G2 - Homo sapiens (Human) - OR51G2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.608 Q7YRV4 RO52_BOVIN 100.000 0.914062 1.09168 TRIM21 - E3 ubiquitin-protein ligase TRIM21 - Bos taurus (Bovine) - TRIM21 gene E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (By similarity). Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI (By similarity). Taurus_UMD|evm.model.AC_000172.1.609 Q8NGK2 O52B4_HUMAN 61.429 0.972028 0.455414 OR52B4 - Olfactory receptor 52B4 - Homo sapiens (Human) - OR52B4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.611 Q8NGK2 O52B4_HUMAN 82.166 0.993651 1.00318 OR52B4 - Olfactory receptor 52B4 - Homo sapiens (Human) - OR52B4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.612 Q17QI2 SSU72_BOVIN 67.010 0.989744 1.00515 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Bos taurus (Bovine) - SSU72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK (By similarity). Taurus_UMD|evm.model.AC_000172.1.614 Q9NP77 SSU72_HUMAN 59.278 0.989744 1.00515 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Homo sapiens (Human) - SSU72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK. Taurus_UMD|evm.model.AC_000172.1.615 Q17QI2 SSU72_BOVIN 63.402 0.989744 1.00515 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Bos taurus (Bovine) - SSU72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK (By similarity). Taurus_UMD|evm.model.AC_000172.1.616 Q17QI2 SSU72_BOVIN 62.371 0.989744 1.00515 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Bos taurus (Bovine) - SSU72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK (By similarity). Taurus_UMD|evm.model.AC_000172.1.617 Q8NGK2 O52B4_HUMAN 72.727 0.922535 0.452229 OR52B4 - Olfactory receptor 52B4 - Homo sapiens (Human) - OR52B4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.618 Q5ZJQ7 SSU72_CHICK 61.340 0.989744 1.00515 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Gallus gallus (Chicken) - SSU72 gene May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination. Taurus_UMD|evm.model.AC_000172.1.619 Q17QI2 SSU72_BOVIN 63.402 0.989744 1.00515 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Bos taurus (Bovine) - SSU72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK (By similarity). Taurus_UMD|evm.model.AC_000172.1.621 Q9UNN5 FAF1_HUMAN 84.190 0.989177 0.710769 FAF1 - FAS-associated factor 1 - Homo sapiens (Human) - FAF1 gene Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). Taurus_UMD|evm.model.AC_000172.1.622 Q17QI2 SSU72_BOVIN 63.918 0.989744 1.00515 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Bos taurus (Bovine) - SSU72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK (By similarity). Taurus_UMD|evm.model.AC_000172.1.624 Q9CY97 SSU72_MOUSE 60.556 0.665428 1.3866 Ssu72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Mus musculus (Mouse) - Ssu72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK. Taurus_UMD|evm.model.AC_000172.1.625 Q8NGK4 O52K1_HUMAN 40.968 0.932927 1.04459 OR52K1 - Olfactory receptor 52K1 - Homo sapiens (Human) - OR52K1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.626 Q8NGF0 O52B6_HUMAN 38.644 0.861765 1.01493 OR52B6 - Olfactory receptor 52B6 - Homo sapiens (Human) - OR52B6 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.627 P23921 RIR1_HUMAN 97.854 0.997475 1 RRM1 - Ribonucleoside-diphosphate reductase large subunit - Homo sapiens (Human) - RRM1 gene Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Taurus_UMD|evm.model.AC_000172.1.628 Q58CP9 STIM1_BOVIN 99.854 0.997076 1.00146 STIM1 - Stromal interaction molecule 1 precursor - Bos taurus (Bovine) - STIM1 gene Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation. Activated following interaction with STIMATE, leading to promote STIM1 conformational switch. Taurus_UMD|evm.model.AC_000172.1.629 P84096 RHOG_MOUSE 98.953 0.989583 1.00524 Rhog - Rho-related GTP-binding protein RhoG precursor - Mus musculus (Mouse) - Rhog gene Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (By similarity). Taurus_UMD|evm.model.AC_000172.1.630 A6H7B8 PGAP2_BOVIN 100.000 0.744118 1.33858 PGAP2 - Post-GPI attachment to proteins factor 2 - Bos taurus (Bovine) - PGAP2 gene Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity). Taurus_UMD|evm.model.AC_000172.1.631 P52948 NUP98_HUMAN 93.722 0.998349 1 NUP98 - Nuclear pore complex protein Nup98-Nup96 precursor - Homo sapiens (Human) - NUP98 gene Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). Taurus_UMD|evm.model.AC_000172.1.632 Q9GZZ6 ACH10_HUMAN 92.093 0.935982 1.00667 CHRNA10 - Neuronal acetylcholine receptor subunit alpha-10 precursor - Homo sapiens (Human) - CHRNA10 gene Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. Taurus_UMD|evm.model.AC_000172.1.633 P52961 NAR1_HUMAN 83.486 0.993884 1 ART1 - GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor - Homo sapiens (Human) - ART1 gene Has ADP-ribosyltransferase activity toward GLP1R. Taurus_UMD|evm.model.AC_000172.1.634 P52961 NAR1_HUMAN 84.564 0.936709 0.966361 ART1 - GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor - Homo sapiens (Human) - ART1 gene Has ADP-ribosyltransferase activity toward GLP1R. Taurus_UMD|evm.model.AC_000172.1.635 P52961 NAR1_HUMAN 77.570 0.993769 0.981651 ART1 - GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor - Homo sapiens (Human) - ART1 gene Has ADP-ribosyltransferase activity toward GLP1R. Taurus_UMD|evm.model.AC_000172.1.636 Q0VC22 NAR5_BOVIN 93.077 0.984733 0.414557 ART5 - Ecto-ADP-ribosyltransferase 5 precursor - Bos taurus (Bovine) - ART5 gene NAD+ ADP-ribosyltransferase activity, peptidyl-arginine ADP-ribosylation Taurus_UMD|evm.model.AC_000172.1.637 Q0VC22 NAR5_BOVIN 99.367 0.507246 1.96519 ART5 - Ecto-ADP-ribosyltransferase 5 precursor - Bos taurus (Bovine) - ART5 gene NAD+ ADP-ribosyltransferase activity, peptidyl-arginine ADP-ribosylation Taurus_UMD|evm.model.AC_000172.1.638 Q0VC22 NAR5_BOVIN 82.993 0.945161 0.981013 ART5 - Ecto-ADP-ribosyltransferase 5 precursor - Bos taurus (Bovine) - ART5 gene NAD+ ADP-ribosyltransferase activity, peptidyl-arginine ADP-ribosylation Taurus_UMD|evm.model.AC_000172.1.639 O62826 TRPC2_BOVIN 99.537 0.341251 2.92361 TRPC2 - Short transient receptor potential channel 2 homolog - Bos taurus (Bovine) - TRPC2 gene Thought to form a receptor-activated calcium permeant cation channel. Taurus_UMD|evm.model.AC_000172.1.640 Q9H920 RN121_HUMAN 98.471 0.993902 1.00306 RNF121 - RING finger protein 121 - Homo sapiens (Human) - RNF121 gene endoplasmic reticulum membrane, Golgi membrane, ubiquitin protein ligase activity, endoplasmic reticulum unfolded protein response, ubiquitin-dependent ERAD pathway Taurus_UMD|evm.model.AC_000172.1.641 O95998 I18BP_HUMAN 68.085 0.880952 1.08247 IL18BP - Interleukin-18-binding protein precursor - Homo sapiens (Human) - IL18BP gene Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. Taurus_UMD|evm.model.AC_000172.1.642 Q14980 NUMA1_HUMAN 85.667 0.999058 1.00426 NUMA1 - Nuclear mitotic apparatus protein 1 - Homo sapiens (Human) - NUMA1 gene Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:23027904, PubMed:22327364, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24996901, PubMed:24371089). Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). Taurus_UMD|evm.model.AC_000172.1.643 Q5EAD8 LRC51_BOVIN 100.000 0.989637 1.00521 LRRC51 - Leucine-rich repeat-containing protein 51 - Bos taurus (Bovine) - LRRC51 gene Taurus_UMD|evm.model.AC_000172.1.644 Q3T0D8 LTOR1_BOVIN 100.000 0.987654 1.00621 LAMTOR1 - Ragulator complex protein LAMTOR1 - Bos taurus (Bovine) - LAMTOR1 gene As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation (By similarity). Taurus_UMD|evm.model.AC_000172.1.645 Q8WZ04 TOMT_HUMAN 96.124 0.992278 0.890034 LRTOMT - Transmembrane O-methyltransferase - Homo sapiens (Human) - LRTOMT gene Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (PubMed:18794526). Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (By similarity). Taurus_UMD|evm.model.AC_000172.1.646 Q3SZ31 APC15_BOVIN 100.000 0.983607 1.00826 ANAPC15 - Anaphase-promoting complex subunit 15 - Bos taurus (Bovine) - ANAPC15 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20 (By similarity). Taurus_UMD|evm.model.AC_000172.1.647 P02702 FOLR1_BOVIN 100.000 0.428884 1.89627 FOLR1 - Folate receptor alpha precursor - Bos taurus (Bovine) - FOLR1 gene Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000172.1.648 P14207 FOLR2_HUMAN 81.818 0.905512 0.996078 FOLR2 - Folate receptor beta precursor - Homo sapiens (Human) - FOLR2 gene Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Taurus_UMD|evm.model.AC_000172.1.649 O15357 SHIP2_HUMAN 96.598 0.998419 1.00556 INPPL1 - Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 - Homo sapiens (Human) - INPPL1 gene Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity. Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1. In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification. Taurus_UMD|evm.model.AC_000172.1.650 O14813 PHX2A_HUMAN 98.592 0.992982 1.00352 PHOX2A - Paired mesoderm homeobox protein 2A - Homo sapiens (Human) - PHOX2A gene May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype. Taurus_UMD|evm.model.AC_000172.1.651 Q5E9N5 CLPB_BOVIN 99.413 0.997067 1.00739 CLPB - Caseinolytic peptidase B protein homolog precursor - Bos taurus (Bovine) - CLPB gene May function as a regulatory ATPase and be related to secretion/protein trafficking process. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6. Taurus_UMD|evm.model.AC_000172.1.652 P14099 PDE2A_BOVIN 99.891 0.997831 1.00109 PDE2A - cGMP-dependent 3',5'-cyclic phosphodiesterase - Bos taurus (Bovine) - PDE2A gene Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Taurus_UMD|evm.model.AC_000172.1.653 Q96P48 ARAP1_HUMAN 86.460 0.966805 0.997241 ARAP1 - Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 - Homo sapiens (Human) - ARAP1 gene Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). Taurus_UMD|evm.model.AC_000172.1.654 Q9Y365 STA10_HUMAN 94.502 0.881459 1.13058 STARD10 - START domain-containing protein 10 - Homo sapiens (Human) - STARD10 gene May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes. Taurus_UMD|evm.model.AC_000172.1.655 Q8NAA4 A16L2_HUMAN 85.784 0.996759 0.996769 ATG16L2 - Protein Atg16l2 - Homo sapiens (Human) - ATG16L2 gene May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner. Taurus_UMD|evm.model.AC_000172.1.656 O94868 FCSD2_HUMAN 97.027 0.997301 1.00135 FCHSD2 - F-BAR and double SH3 domains protein 2 - Homo sapiens (Human) - FCHSD2 gene Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). Taurus_UMD|evm.model.AC_000172.1.657 O18951 P2RY2_BOVIN 97.744 0.349206 2.84211 P2RY2 - P2Y purinoceptor 2 - Bos taurus (Bovine) - P2RY2 gene Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000172.1.658 Q15077 P2RY6_HUMAN 92.683 0.993921 1.00305 P2RY6 - P2Y purinoceptor 6 - Homo sapiens (Human) - P2RY6 gene Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000172.1.659 Q96PE2 ARHGH_HUMAN 93.814 0.445658 0.932138 ARHGEF17 - Rho guanine nucleotide exchange factor 17 - Homo sapiens (Human) - ARHGEF17 gene Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Taurus_UMD|evm.model.AC_000172.1.661 Q969Z4 TR19L_HUMAN 82.423 0.974478 1.00233 RELT - Tumor necrosis factor receptor superfamily member 19L precursor - Homo sapiens (Human) - RELT gene May play a role in apoptosis (PubMed:28688764, PubMed:19969290). Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727). Involved in dental enamel formation (PubMed:30506946). Taurus_UMD|evm.model.AC_000172.1.662 Q8BGZ2 F168A_MOUSE 99.590 0.852632 1.16803 Fam168a - Protein FAM168A - Mus musculus (Mouse) - Fam168a gene In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels. Taurus_UMD|evm.model.AC_000172.1.663 Q9UF11 PKHB1_HUMAN 82.305 0.990431 0.860082 PLEKHB1 - Pleckstrin homology domain-containing family B member 1 - Homo sapiens (Human) - PLEKHB1 gene integral component of membrane, phototransduction, regulation of cell differentiation Taurus_UMD|evm.model.AC_000172.1.664 Q9WVB1 RAB6A_RAT 99.519 0.990431 1.00481 Rab6a - Ras-related protein Rab-6A - Rattus norvegicus (Rat) - Rab6a gene Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER. Taurus_UMD|evm.model.AC_000172.1.665 Q2YDI5 RM48_BOVIN 99.515 0.836735 1.15566 MRPL48 - 39S ribosomal protein L48, mitochondrial precursor - Bos taurus (Bovine) - MRPL48 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome Taurus_UMD|evm.model.AC_000172.1.666 Q8BT51 COA4_MOUSE 87.342 0.917647 0.977011 COA4 - Cytochrome c oxidase assembly factor 4 homolog, mitochondrial - Mus musculus (Mouse) - COA4 gene Putative COX assembly factor. Taurus_UMD|evm.model.AC_000172.1.667 Q148I1 PAAF1_BOVIN 100.000 0.994911 1.00255 PAAF1 - Proteasomal ATPase-associated factor 1 - Bos taurus (Bovine) - PAAF1 gene Inhibits proteasome 26S assembly and activity by impairing the association of the 19S regulatory complex with the 20S core. Protects SUPT6H from proteasomal degradation (By similarity). Taurus_UMD|evm.model.AC_000172.1.668 P59910 DJB13_HUMAN 92.089 0.993691 1.00316 DNAJB13 - DnaJ homolog subfamily B member 13 - Homo sapiens (Human) - DNAJB13 gene Plays a role in the formation of the central complex of ciliary and flagellar axonemes. Taurus_UMD|evm.model.AC_000172.1.669 Q3SZI5 UCP2_BOVIN 100.000 0.993548 1.00324 UCP2 - Mitochondrial uncoupling protein 2 - Bos taurus (Bovine) - UCP2 gene UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity). Taurus_UMD|evm.model.AC_000172.1.670 O77792 UCP3_BOVIN 100.000 0.890728 0.971061 UCP3 - Mitochondrial uncoupling protein 3 - Bos taurus (Bovine) - UCP3 gene UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity). Taurus_UMD|evm.model.AC_000172.1.671 Q4AC94 C2CD3_HUMAN 82.655 0.999147 0.997025 C2CD3 - C2 domain-containing protein 3 - Homo sapiens (Human) - C2CD3 gene Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. Taurus_UMD|evm.model.AC_000172.1.672 Q58DN4 PPME1_BOVIN 89.737 0.977011 0.915789 PPME1 - Protein phosphatase methylesterase 1 - Bos taurus (Bovine) - PPME1 gene Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity). Taurus_UMD|evm.model.AC_000172.1.673 Q75UG4 P4HA3_BOVIN 100.000 0.99633 1.00184 P4HA3 - Prolyl 4-hydroxylase subunit alpha-3 precursor - Bos taurus (Bovine) - P4HA3 gene Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Taurus_UMD|evm.model.AC_000172.1.674 P83883 RL36A_RAT 100.000 0.981308 1.00943 Rpl36a - 60S ribosomal protein L36a - Rattus norvegicus (Rat) - Rpl36a gene cytosolic large ribosomal subunit, nucleus, response to organic substance, response to retinoic acid Taurus_UMD|evm.model.AC_000172.1.675 Q5R979 PGM2L_PONAB 96.463 0.99679 1.00161 PGM2L1 - Glucose 1,6-bisphosphate synthase - Pongo abelii (Sumatran orangutan) - PGM2L1 gene Glucose 1,6-bisphosphate synthase using 1,3-bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars as acceptors, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1-phosphate. 5 or 6-phosphosugars are bad substrates, with the exception of glucose 6-phosphate. Also synthesizes ribose 1,5-bisphosphate. Has only low phosphopentomutase and phosphoglucomutase activities (By similarity). Taurus_UMD|evm.model.AC_000172.1.676 Q9Y6H6 KCNE3_HUMAN 88.350 0.98 0.970874 KCNE3 - Potassium voltage-gated channel subfamily E member 3 - Homo sapiens (Human) - KCNE3 gene Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:12954870). Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship. Taurus_UMD|evm.model.AC_000172.1.678 A6NK58 LIPT2_HUMAN 83.983 0.99115 0.978355 LIPT2 - Putative lipoyltransferase 2, mitochondrial precursor - Homo sapiens (Human) - LIPT2 gene Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes, which catalyze essential redox reactions (PubMed:28757203). Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). Taurus_UMD|evm.model.AC_000172.1.679 P84798 DPOD3_BOVIN 94.850 0.995699 0.997854 POLD3 - DNA polymerase delta subunit 3 - Bos taurus (Bovine) - POLD3 gene Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS, as a component of the tetrametric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7. Taurus_UMD|evm.model.AC_000172.1.680 Q6WN34 CRDL2_HUMAN 89.276 0.821192 1.05594 CHRDL2 - Chordin-like protein 2 precursor - Homo sapiens (Human) - CHRDL2 gene May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation. Taurus_UMD|evm.model.AC_000172.1.681 F1MRW8 RN169_BOVIN 100.000 0.975887 1.02322 RNF169 - E3 ubiquitin-protein ligase RNF169 - Bos taurus (Bovine) - RNF169 gene Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. Taurus_UMD|evm.model.AC_000172.1.682 Q7PCK7 XRRA1_BOVIN 90.134 0.725395 1.49909 XRRA1 - X-ray radiation resistance-associated protein 1 - Bos taurus (Bovine) - XRRA1 gene May be involved in the response of cells to X-ray radiation. Taurus_UMD|evm.model.AC_000172.1.683 Q9CYN2 SPCS2_MOUSE 89.815 0.784672 1.21239 Spcs2 - Signal peptidase complex subunit 2 - Mus musculus (Mouse) - Spcs2 gene Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Taurus_UMD|evm.model.AC_000172.1.684 O97859 NEUR3_BOVIN 99.533 0.972665 1.0257 NEU3 - Sialidase-3 - Bos taurus (Bovine) - NEU3 gene Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:9988745). Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (By similarity). Taurus_UMD|evm.model.AC_000172.1.685 O94956 SO2B1_HUMAN 80.959 0.997183 1.00141 SLCO2B1 - Solute carrier organic anion transporter family member 2B1 - Homo sapiens (Human) - SLCO2B1 gene Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. Taurus_UMD|evm.model.AC_000172.1.686 P0DKB5 TPBGL_HUMAN 89.974 0.994872 1.02094 TPBGL - Trophoblast glycoprotein-like precursor - Homo sapiens (Human) - TPBGL gene Taurus_UMD|evm.model.AC_000172.1.687 P17870 ARRB1_BOVIN 100.000 0.995227 1.00239 ARRB1 - Beta-arrestin-1 - Bos taurus (Bovine) - ARRB1 gene Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in IL8-mediated granule release in neutrophils. Binds phosphoinositides. Binds inositol hexakisphosphate (InsP6) (By similarity). Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3 (By similarity). Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH. Participates in the recruitment of the ubiquitin-protein ligase to the receptor (By similarity). Taurus_UMD|evm.model.AC_000172.1.688 Q0Z8U2 RS3_PIG 100.000 0.991803 1.00412 RPS3 - 40S ribosomal protein S3 - Sus scrofa (Pig) - RPS3 gene Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protein OGG1. Enhances the uracil excision activity of UNG1. Also stimulates the cleavage of the phosphodiester backbone by APEX1. When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage. Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide. Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes. Represses its own translation by binding to its cognate mRNA. Binds to and protects TP53/p53 from MDM2-mediated ubiquitination. Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization. Involved in induction of apoptosis through its role in activation of CASP8. Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5. Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation. Taurus_UMD|evm.model.AC_000172.1.689 Q6PF15 KLH35_HUMAN 89.537 0.996558 0.996569 KLHL35 - Kelch-like protein 35 - Homo sapiens (Human) - KLHL35 gene Taurus_UMD|evm.model.AC_000172.1.690 Q8WTR4 GDPD5_HUMAN 92.893 0.9967 1.00165 GDPD5 - Glycerophosphodiester phosphodiesterase domain-containing protein 5 - Homo sapiens (Human) - GDPD5 gene Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (By similarity). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine (By similarity). Taurus_UMD|evm.model.AC_000172.1.691 Q2KJH6 SERPH_BOVIN 100.000 0.914474 1.09091 SERPINH1 - Serpin H1 precursor - Bos taurus (Bovine) - SERPINH1 gene Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen (By similarity). Taurus_UMD|evm.model.AC_000172.1.692 Q96JE9 MAP6_HUMAN 83.465 0.222423 1.36039 MAP6 - Microtubule-associated protein 6 - Homo sapiens (Human) - MAP6 gene Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity). Taurus_UMD|evm.model.AC_000172.1.693 Q3SYC2 MOGT2_HUMAN 73.353 0.99403 1.00299 MOGAT2 - 2-acylglycerol O-acyltransferase 2 - Homo sapiens (Human) - MOGAT2 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). Taurus_UMD|evm.model.AC_000172.1.694 Q80W94 MOGT2_MOUSE 69.670 0.990881 0.98503 Mogat2 - 2-acylglycerol O-acyltransferase 2 - Mus musculus (Mouse) - Mogat2 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). Taurus_UMD|evm.model.AC_000172.1.695 Q80W94 MOGT2_MOUSE 65.152 0.364162 0.517964 Mogat2 - 2-acylglycerol O-acyltransferase 2 - Mus musculus (Mouse) - Mogat2 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). Taurus_UMD|evm.model.AC_000172.1.696 Q80W94 MOGT2_MOUSE 77.705 0.952978 0.95509 Mogat2 - 2-acylglycerol O-acyltransferase 2 - Mus musculus (Mouse) - Mogat2 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). Taurus_UMD|evm.model.AC_000172.1.697 Q3SYC2 MOGT2_HUMAN 73.361 0.971888 0.745509 MOGAT2 - 2-acylglycerol O-acyltransferase 2 - Homo sapiens (Human) - MOGAT2 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). Taurus_UMD|evm.model.AC_000172.1.698 Q9P0L2 MARK1_HUMAN 98.734 0.975 0.100629 MARK1 - Serine/threonine-protein kinase MARK1 - Homo sapiens (Human) - MARK1 gene Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Taurus_UMD|evm.model.AC_000172.1.699 Q9P0L2 MARK1_HUMAN 92.877 0.918635 0.479245 MARK1 - Serine/threonine-protein kinase MARK1 - Homo sapiens (Human) - MARK1 gene Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Taurus_UMD|evm.model.AC_000172.1.700 Q9P0L2 MARK1_HUMAN 97.917 0.284848 0.207547 MARK1 - Serine/threonine-protein kinase MARK1 - Homo sapiens (Human) - MARK1 gene Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Taurus_UMD|evm.model.AC_000172.1.701 Q80W94 MOGT2_MOUSE 62.613 0.990196 0.610778 Mogat2 - 2-acylglycerol O-acyltransferase 2 - Mus musculus (Mouse) - Mogat2 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). Taurus_UMD|evm.model.AC_000172.1.702 Q80W94 MOGT2_MOUSE 67.066 0.993994 0.997006 Mogat2 - 2-acylglycerol O-acyltransferase 2 - Mus musculus (Mouse) - Mogat2 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). Taurus_UMD|evm.model.AC_000172.1.703 Q70VZ8 DGAT2_BOVIN 99.723 0.994475 1.00277 DGAT2 - Diacylglycerol O-acyltransferase 2 - Bos taurus (Bovine) - DGAT2 gene Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (By similarity). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). Taurus_UMD|evm.model.AC_000172.1.704 Q9P2Y5 UVRAG_HUMAN 93.562 0.997143 1.00143 UVRAG - UV radiation resistance-associated gene protein - Homo sapiens (Human) - UVRAG gene Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). Taurus_UMD|evm.model.AC_000172.1.705 O96014 WNT11_HUMAN 98.305 0.994366 1.00282 WNT11 - Protein Wnt-11 precursor - Homo sapiens (Human) - WNT11 gene Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Taurus_UMD|evm.model.AC_000172.1.706 O43422 P52K_HUMAN 96.719 0.997379 1.00263 THAP12 - 52 kDa repressor of the inhibitor of the protein kinase - Homo sapiens (Human) - THAP12 gene Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. Taurus_UMD|evm.model.AC_000172.1.707 Q3ZCU0 GVQW3_HUMAN 94.656 0.772455 0.65748 GVQW3 - Protein GVQW3 - Homo sapiens (Human) - GVQW3 gene Taurus_UMD|evm.model.AC_000172.1.708 Q7Z589 EMSY_HUMAN 96.111 0.945637 1.05749 EMSY - BRCA2-interacting transcriptional repressor EMSY - Homo sapiens (Human) - EMSY gene Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Taurus_UMD|evm.model.AC_000172.1.709 Q14392 LRC32_HUMAN 84.806 0.551546 1.75831 LRRC32 - Transforming growth factor beta activator LRRC32 precursor - Homo sapiens (Human) - LRRC32 gene Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity). Taurus_UMD|evm.model.AC_000172.1.710 Q8WUA8 TSK_HUMAN 84.703 0.980501 1.017 TSKU - Tsukushi precursor - Homo sapiens (Human) - TSKU gene Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye. Plays a role in regulating the hair cycle by controlling TGFB1 signaling. Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth. Essential for terminal differentiation of hippocampal neural stem cells. Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size. Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells. Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence. Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver. In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure. In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis. Taurus_UMD|evm.model.AC_000172.1.712 Q9NUN7 ACER3_HUMAN 81.111 0.988971 1.01873 ACER3 - Alkaline ceramidase 3 - Homo sapiens (Human) - ACER3 gene Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:20068046, PubMed:26792856, PubMed:20207939, PubMed:11356846, PubMed:30575723). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20068046). Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma (PubMed:20207939). Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (By similarity). By regulating the levels of proinflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (By similarity). Taurus_UMD|evm.model.AC_000172.1.713 O77737 B2CL1_PIG 76.250 0.77451 0.437768 BCL2L1 - Bcl-2-like protein 1 - Sus scrofa (Pig) - BCL2L1 gene Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). Taurus_UMD|evm.model.AC_000172.1.714 Q6ZMB0 B3GN6_HUMAN 80.990 0.994737 0.989583 B3GNT6 - Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase - Homo sapiens (Human) - B3GNT6 gene Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs. Taurus_UMD|evm.model.AC_000172.1.715 P57053 H2BFS_HUMAN 91.026 0.6875 0.888889 H2BS1 - Histone H2B type F-S - Homo sapiens (Human) - H2BS1 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000172.1.716 O15484 CAN5_HUMAN 93.594 0.99688 1.00156 CAPN5 - Calpain-5 - Homo sapiens (Human) - CAPN5 gene Calcium-regulated non-lysosomal thiol-protease. Taurus_UMD|evm.model.AC_000172.1.717 Q28970 MYO7A_PIG 96.964 0.250225 3.93286 MYO7A - Unconventional myosin-VIIa - Sus scrofa (Pig) - MYO7A gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Taurus_UMD|evm.model.AC_000172.1.718 Q3TT99 GDPD4_MOUSE 62.500 0.269303 0.84019 Gdpd4 - Glycerophosphodiester phosphodiesterase domain-containing protein 4 - Mus musculus (Mouse) - Gdpd4 gene Taurus_UMD|evm.model.AC_000172.1.720 Q9BYT9 ANO3_HUMAN 90.777 0.997875 0.959225 ANO3 - Anoctamin-3 - Homo sapiens (Human) - ANO3 gene Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:21984732). Taurus_UMD|evm.model.AC_000172.1.721 A7MBD8 SC5AC_BOVIN 100.000 0.996764 1.00162 SLC5A12 - Sodium-coupled monocarboxylate transporter 2 - Bos taurus (Bovine) - SLC5A12 gene Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity). Taurus_UMD|evm.model.AC_000172.1.722 Q5E9H1 FIBIN_BOVIN 100.000 0.990566 1.00474 FIBIN - Fin bud initiation factor homolog precursor - Bos taurus (Bovine) - FIBIN gene Taurus_UMD|evm.model.AC_000172.1.723 O75936 BODG_HUMAN 87.080 0.994845 1.00258 BBOX1 - Gamma-butyrobetaine dioxygenase - Homo sapiens (Human) - BBOX1 gene Catalyzes the formation of L-carnitine from gamma-butyrobetaine. Taurus_UMD|evm.model.AC_000172.1.724 Q96HJ3 CCD34_HUMAN 78.226 0.986413 0.986595 CCDC34 - Coiled-coil domain-containing protein 34 - Homo sapiens (Human) - CCDC34 gene Taurus_UMD|evm.model.AC_000172.1.725 F1MLX5 LGR4_BOVIN 100.000 0.997899 1.00105 LGR4 - Leucine-rich repeat-containing G-protein coupled receptor 4 precursor - Bos taurus (Bovine) - LGR4 gene Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however required additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP. Taurus_UMD|evm.model.AC_000172.1.726 Q792I0 LIN7C_RAT 100.000 0.989899 1.00508 Lin7c - Protein lin-7 homolog C - Rattus norvegicus (Rat) - Lin7c gene Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Taurus_UMD|evm.model.AC_000172.1.727 Q95106 BDNF_BOVIN 100.000 0.992032 1.004 BDNF - Brain-derived neurotrophic factor precursor - Bos taurus (Bovine) - BDNF gene Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity). Taurus_UMD|evm.model.AC_000172.1.728 Q8NI77 KI18A_HUMAN 91.525 0.685714 0.857461 KIF18A - Kinesin-like protein KIF18A - Homo sapiens (Human) - KIF18A gene Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. Taurus_UMD|evm.model.AC_000172.1.729 A0JN95 MET15_BOVIN 100.000 0.708551 1.40786 METTL15 - 12S rRNA N4-methylcytidine methyltransferase precursor - Bos taurus (Bovine) - METTL15 gene N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA. Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits. Taurus_UMD|evm.model.AC_000172.1.730 Q05037 KCNA4_BOVIN 99.546 0.996979 1.00303 KCNA4 - Potassium voltage-gated channel subfamily A member 4 - Bos taurus (Bovine) - KCNA4 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:1505668). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:1505668). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (By similarity). Taurus_UMD|evm.model.AC_000172.1.731 P04837 FSHB_BOVIN 83.721 0.982759 0.899225 FSHB - Follitropin subunit beta precursor - Bos taurus (Bovine) - FSHB gene Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. Taurus_UMD|evm.model.AC_000172.1.732 P04837 FSHB_BOVIN 100.000 0.984615 1.00775 FSHB - Follitropin subunit beta precursor - Bos taurus (Bovine) - FSHB gene Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. Taurus_UMD|evm.model.AC_000172.1.733 Q5EA92 AL14E_BOVIN 100.000 0.992337 1.00385 ARL14EP - ARL14 effector protein - Bos taurus (Bovine) - ARL14EP gene Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. Taurus_UMD|evm.model.AC_000172.1.735 Q5REB1 MPPD2_PONAB 100.000 0.99322 1.0034 MPPED2 - Metallophosphoesterase MPPED2 - Pongo abelii (Sumatran orangutan) - MPPED2 gene Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system. Taurus_UMD|evm.model.AC_000172.1.736 M0R2J8 DCDC1_HUMAN 79.022 0.988717 0.795289 DCDC1 - Doublecortin domain-containing protein 1 - Homo sapiens (Human) - DCDC1 gene Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis (PubMed:22159412). Taurus_UMD|evm.model.AC_000172.1.737 Q5R893 H2B1_PONAB 92.857 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000172.1.738 M0R2J8 DCDC1_HUMAN 82.759 0.817967 0.237241 DCDC1 - Doublecortin domain-containing protein 1 - Homo sapiens (Human) - DCDC1 gene Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis (PubMed:22159412). Taurus_UMD|evm.model.AC_000172.1.739 Q0VBY7 DJC24_BOVIN 84.564 0.664894 1.26174 DNAJC24 - DnaJ homolog subfamily C member 24 - Bos taurus (Bovine) - DNAJC24 gene Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) (By similarity). Taurus_UMD|evm.model.AC_000172.1.740 Q96LU5 IMP1L_HUMAN 92.169 0.988024 1.00602 IMMP1L - Mitochondrial inner membrane protease subunit 1 - Homo sapiens (Human) - IMMP1L gene Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. Taurus_UMD|evm.model.AC_000172.1.742 Q2TBH6 ELP4_BOVIN 99.764 0.995283 1.00236 ELP4 - Elongator complex protein 4 - Bos taurus (Bovine) - ELP4 gene Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Taurus_UMD|evm.model.AC_000172.1.743 Q1LZF1 PAX6_BOVIN 94.964 0.480925 2.04976 PAX6 - Paired box protein Pax-6 - Bos taurus (Bovine) - PAX6 gene Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity). Taurus_UMD|evm.model.AC_000172.1.745 Q15293 RCN1_HUMAN 90.909 0.619048 1.26888 RCN1 - Reticulocalbin-1 precursor - Homo sapiens (Human) - RCN1 gene May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. Taurus_UMD|evm.model.AC_000172.1.747 P49953 WT1_SMIMA 96.653 0.775244 1.28452 WT1 - Wilms tumor protein homolog - Sminthopsis macroura (Stripe-faced dunnart) - WT1 gene Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Taurus_UMD|evm.model.AC_000172.1.748 Q7L2H7 EIF3M_HUMAN 99.733 0.994667 1.00267 EIF3M - Eukaryotic translation initiation factor 3 subunit M - Homo sapiens (Human) - EIF3M gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Taurus_UMD|evm.model.AC_000172.1.749 Q6ZRK6 CCD73_HUMAN 68.421 0.997953 0.905468 CCDC73 - Coiled-coil domain-containing protein 73 - Homo sapiens (Human) - CCDC73 gene Taurus_UMD|evm.model.AC_000172.1.750 Q9BZD6 TMG4_HUMAN 82.456 0.991266 1.01327 PRRG4 - Transmembrane gamma-carboxyglutamic acid protein 4 precursor - Homo sapiens (Human) - PRRG4 gene May control axon guidance across the CNS (PubMed:28859078). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (PubMed:28859078). Taurus_UMD|evm.model.AC_000172.1.751 Q2KHR3 QSER1_HUMAN 89.304 0.932832 1.07262 QSER1 - Glutamine and serine-rich protein 1 - Homo sapiens (Human) - QSER1 gene Taurus_UMD|evm.model.AC_000172.1.752 Q95JW3 DEPD7_MACFA 91.206 0.934118 0.846614 DEPDC7 - DEP domain-containing protein 7 - Macaca fascicularis (Crab-eating macaque) - DEPDC7 gene Taurus_UMD|evm.model.AC_000172.1.754 Q9NUJ3 T11L1_HUMAN 87.033 0.996078 1.00196 TCP11L1 - T-complex protein 11-like protein 1 - Homo sapiens (Human) - TCP11L1 gene microtubule, signal transduction Taurus_UMD|evm.model.AC_000172.1.755 Q12996 CSTF3_HUMAN 98.442 0.577617 0.772664 CSTF3 - Cleavage stimulation factor subunit 3 - Homo sapiens (Human) - CSTF3 gene One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. Taurus_UMD|evm.model.AC_000172.1.756 Q9H422 HIPK3_HUMAN 92.763 0.99583 0.986831 HIPK3 - Homeodomain-interacting protein kinase 3 - Homo sapiens (Human) - HIPK3 gene Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Taurus_UMD|evm.model.AC_000172.1.757 Q6ZVL6 K154L_HUMAN 79.453 0.866511 1.15468 KIAA1549L - UPF0606 protein KIAA1549L - Homo sapiens (Human) - KIAA1549L gene Taurus_UMD|evm.model.AC_000172.1.758 A8WFF7 CK091_BOVIN 100.000 0.989011 0.943005 Uncharacterized protein C11orf91 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000172.1.759 O62680 CD59_PIG 61.157 0.967213 0.99187 CD59 - CD59 glycoprotein precursor - Sus scrofa (Pig) - CD59 gene Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. Taurus_UMD|evm.model.AC_000172.1.760 A6H7H7 FBX3_BOVIN 100.000 0.995745 1.00213 FBXO3 - F-box only protein 3 - Bos taurus (Bovine) - FBXO3 gene Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). Taurus_UMD|evm.model.AC_000172.1.761 Q1LZ94 RBTN2_BOVIN 100.000 0.697778 1.42405 LMO2 - Rhombotin-2 - Bos taurus (Bovine) - LMO2 gene Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. Taurus_UMD|evm.model.AC_000172.1.762 Q1LZB6 CAPR1_BOVIN 97.740 0.997114 0.978814 CAPRIN1 - Caprin-1 - Bos taurus (Bovine) - CAPRIN1 gene May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs. Taurus_UMD|evm.model.AC_000172.1.763 Q9H0A0 NAT10_HUMAN 96.394 0.998053 1.00195 NAT10 - RNA cytidine acetyltransferase - Homo sapiens (Human) - NAT10 gene RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Taurus_UMD|evm.model.AC_000172.1.764 Q8N961 ABTB2_HUMAN 92.000 0.997949 0.95122 ABTB2 - Ankyrin repeat and BTB/POZ domain-containing protein 2 - Homo sapiens (Human) - ABTB2 gene May be involved in the initiation of hepatocyte growth. Taurus_UMD|evm.model.AC_000172.1.765 P00432 CATA_BOVIN 100.000 0.996212 1.0019 CAT - Catalase - Bos taurus (Bovine) - CAT gene Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells. Taurus_UMD|evm.model.AC_000172.1.766 Q58DT0 ELF5_BOVIN 100.000 0.992188 1.00392 ELF5 - ETS-related transcription factor Elf-5 - Bos taurus (Bovine) - ELF5 gene Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT] (By similarity). Taurus_UMD|evm.model.AC_000172.1.767 Q32LN0 EHF_BOVIN 100.000 0.993355 1.00333 EHF - ETS homologous factor - Bos taurus (Bovine) - EHF gene Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter (By similarity). Taurus_UMD|evm.model.AC_000172.1.768 Q0VCJ2 MTNB_BOVIN 100.000 0.99177 1.00413 APIP - Methylthioribulose-1-phosphate dehydratase - Bos taurus (Bovine) - APIP gene Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. Taurus_UMD|evm.model.AC_000172.1.769 P22439 ODPX_BOVIN 100.000 0.996016 1.002 PDHX - Pyruvate dehydrogenase protein X component precursor - Bos taurus (Bovine) - PDHX gene Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. Taurus_UMD|evm.model.AC_000172.1.770 Q29423 CD44_BOVIN 99.281 0.162162 2.32514 CD44 - CD44 antigen precursor - Bos taurus (Bovine) - CD44 gene Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. Taurus_UMD|evm.model.AC_000172.1.771 P43004 EAA2_HUMAN 97.007 0.967577 1.02091 SLC1A2 - Excitatory amino acid transporter 2 - Homo sapiens (Human) - SLC1A2 gene Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity). Taurus_UMD|evm.model.AC_000172.1.773 Q5E9P5 PAMR1_BOVIN 99.861 0.997226 1.00139 PAMR1 - Inactive serine protease PAMR1 precursor - Bos taurus (Bovine) - PAMR1 gene May play a role in regeneration of skeletal muscle. Taurus_UMD|evm.model.AC_000172.1.774 Q86VR8 FJX1_HUMAN 96.540 0.979592 0.672769 FJX1 - Four-jointed box protein 1 precursor - Homo sapiens (Human) - FJX1 gene Acts as an inhibitor of dendrite extension and branching. Taurus_UMD|evm.model.AC_000172.1.775 A6QQX5 TRI44_BOVIN 100.000 0.9941 1.00296 TRIM44 - Tripartite motif-containing protein 44 - Bos taurus (Bovine) - TRIM44 gene May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17 (By similarity). Is a negative regulator of PAX6 expression (By similarity). Taurus_UMD|evm.model.AC_000172.1.776 Q86YD5 LRAD3_HUMAN 97.971 0.99422 1.0029 LDLRAD3 - Low-density lipoprotein receptor class A domain-containing protein 3 precursor - Homo sapiens (Human) - LDLRAD3 gene May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. Taurus_UMD|evm.model.AC_000172.1.777 Q2TBN5 COMD9_BOVIN 99.495 0.98995 1.00505 COMMD9 - COMM domain-containing protein 9 - Bos taurus (Bovine) - COMMD9 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits. Taurus_UMD|evm.model.AC_000172.1.778 Q5E9R0 PRR5L_BOVIN 95.380 0.99435 0.961957 PRR5L - Proline-rich protein 5-like - Bos taurus (Bovine) - PRR5L gene Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration. Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress. Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress. Taurus_UMD|evm.model.AC_000172.1.779 Q3ZCC3 TRAF6_BOVIN 100.000 0.996317 1.00185 TRAF6 - TNF receptor-associated factor 6 - Bos taurus (Bovine) - TRAF6 gene E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. Taurus_UMD|evm.model.AC_000172.1.780 Q867B5 RAG1_PIG 92.330 0.998084 1.00096 RAG1 - V(D)J recombination-activating protein 1 - Sus scrofa (Pig) - RAG1 gene Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination. Mediates polyubiquitination of KPNA1 (By similarity). Taurus_UMD|evm.model.AC_000172.1.781 P34089 RAG2_RABIT 91.271 0.996212 1.0019 RAG2 - V(D)J recombination-activating protein 2 - Oryctolagus cuniculus (Rabbit) - RAG2 gene Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3 (By similarity). Taurus_UMD|evm.model.AC_000172.1.782 Q3ZBP0 IFTAP_BOVIN 100.000 0.99177 1.00413 IFTAP - Intraflagellar transport-associated protein - Bos taurus (Bovine) - IFTAP gene Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex. Taurus_UMD|evm.model.AC_000172.1.784 Q91YU8 SSF1_MOUSE 38.916 0.927152 0.321277 Ppan - Suppressor of SWI4 1 homolog - Mus musculus (Mouse) - Ppan gene May have a role in cell growth. Taurus_UMD|evm.model.AC_000172.1.788 Q9HCJ2 LRC4C_HUMAN 99.688 0.99688 1.00156 LRRC4C - Leucine-rich repeat-containing protein 4C precursor - Homo sapiens (Human) - LRRC4C gene May promote neurite outgrowth of developing thalamic neurons. Taurus_UMD|evm.model.AC_000172.1.789 Q0III0 MSD3_BOVIN 100.000 0.992754 1.00364 MSANTD3 - Myb/SANT-like DNA-binding domain-containing protein 3 - Bos taurus (Bovine) - MSANTD3 gene Taurus_UMD|evm.model.AC_000172.1.790 Q14129 DGCR6_HUMAN 94.595 0.973333 0.340909 DGCR6 - Protein DGCR6 - Homo sapiens (Human) - DGCR6 gene May play a role in neural crest cell migration into the third and fourth pharyngeal pouches. Taurus_UMD|evm.model.AC_000172.1.791 Q5R644 API5_PONAB 98.753 0.991736 0.960317 API5 - Apoptosis inhibitor 5 - Pongo abelii (Sumatran orangutan) - API5 gene Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis (By similarity). Taurus_UMD|evm.model.AC_000172.1.792 B5DEL3 TTC17_RAT 93.990 0.981148 1.01836 Ttc17 - Tetratricopeptide repeat protein 17 - Rattus norvegicus (Rat) - Ttc17 gene Plays a role in primary ciliogenesis by modulating actin polymerization. Taurus_UMD|evm.model.AC_000172.1.793 Q32L00 ALKB3_BOVIN 100.000 0.488636 1.84615 ALKBH3 - Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 - Bos taurus (Bovine) - ALKBH3 gene Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron. Taurus_UMD|evm.model.AC_000172.1.794 Q7Z7L8 CK096_HUMAN 94.215 0.967742 0.285057 C11orf96 - Uncharacterized protein C11orf96 - Homo sapiens (Human) - C11orf96 gene Taurus_UMD|evm.model.AC_000172.1.796 Q4AC99 1A1L2_HUMAN 67.145 0.963605 1.01585 ACCSL - Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 - Homo sapiens (Human) - ACCSL gene Taurus_UMD|evm.model.AC_000172.1.797 Q5E9H2 1A1L1_BOVIN 99.801 0.996024 1.00199 ACCS - 1-aminocyclopropane-1-carboxylate synthase-like protein 1 - Bos taurus (Bovine) - ACCS gene Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine. Taurus_UMD|evm.model.AC_000172.1.798 O77783 EXT2_BOVIN 99.721 0.903023 1.10585 EXT2 - Exostosin-2 - Bos taurus (Bovine) - EXT2 gene Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. Taurus_UMD|evm.model.AC_000172.1.799 Q4LAL6 ALX4_BOVIN 99.351 0.894737 0.43073 ALX4 - Homeobox protein aristaless-like 4 - Bos taurus (Bovine) - ALX4 gene Transcription factor involved in skull and limb development. Taurus_UMD|evm.model.AC_000172.1.801 P27701 CD82_HUMAN 76.866 0.754237 1.32584 CD82 - CD82 antigen - Homo sapiens (Human) - CD82 gene Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. Taurus_UMD|evm.model.AC_000172.1.802 Q58CY8 TSN18_BOVIN 96.098 0.882883 0.891566 TSPAN18 - Tetraspanin-18 - Bos taurus (Bovine) - TSPAN18 gene integral component of plasma membrane Taurus_UMD|evm.model.AC_000172.1.803 P0C1H3 H2B1_CHICK 98.507 0.970588 0.539683 H2B-I - Histone H2B 1/2/3/4/6 - Gallus gallus (Chicken) - H2B-I gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000172.1.804 Q58CY8 TSN18_BOVIN 97.674 0.254545 0.662651 TSPAN18 - Tetraspanin-18 - Bos taurus (Bovine) - TSPAN18 gene integral component of plasma membrane Taurus_UMD|evm.model.AC_000172.1.806 A2AGX3 PRD11_MOUSE 74.699 0.480469 0.906195 Prdm11 - PR domain-containing protein 11 - Mus musculus (Mouse) - Prdm11 gene May be involved in transcription regulation. Taurus_UMD|evm.model.AC_000172.1.807 Q9NQV5 PRD11_HUMAN 90.580 0.270403 1.99022 PRDM11 - PR domain-containing protein 11 - Homo sapiens (Human) - PRDM11 gene May be involved in transcription regulation. Taurus_UMD|evm.model.AC_000172.1.808 Q7L8C5 SYT13_HUMAN 92.254 0.995316 1.00235 SYT13 - Synaptotagmin-13 - Homo sapiens (Human) - SYT13 gene May be involved in transport vesicle docking to the plasma membrane. Taurus_UMD|evm.model.AC_000172.1.810 O43916 CHST1_HUMAN 97.810 0.995146 1.00243 CHST1 - Carbohydrate sulfotransferase 1 - Homo sapiens (Human) - CHST1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Taurus_UMD|evm.model.AC_000172.1.813 A6QM03 FUCT1_BOVIN 100.000 0.994521 1.00275 SLC35C1 - GDP-fucose transporter 1 - Bos taurus (Bovine) - SLC35C1 gene Involved in GDP-fucose import from the cytoplasm into the Golgi lumen. Taurus_UMD|evm.model.AC_000172.1.814 Q49AN0 CRY2_HUMAN 90.925 0.965458 0.976391 CRY2 - Cryptochrome-2 - Homo sapiens (Human) - CRY2 gene Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. Less potent transcriptional repressor in cerebellum and liver than CRY1, though less effective in lengthening the period of the SCN oscillator. Seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY1, dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. May mediate circadian regulation of cAMP signaling and gluconeogenesis by blocking glucagon-mediated increases in intracellular cAMP concentrations and in CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-ARNTL/BMAL1 induced transcription of NAMPT (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Represses the transcriptional activity of NR1I2 (By similarity). Taurus_UMD|evm.model.AC_000172.1.815 Q9UQF2 JIP1_HUMAN 93.539 0.997187 1 MAPK8IP1 - C-Jun-amino-terminal kinase-interacting protein 1 - Homo sapiens (Human) - MAPK8IP1 gene The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. Taurus_UMD|evm.model.AC_000172.1.816 A5PK62 CK094_BOVIN 100.000 0.98 1.0101 Uncharacterized protein C11orf94 homolog precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000172.1.817 Q2KII7 PEX16_BOVIN 100.000 0.993921 1.00305 PEX16 - Peroxisomal membrane protein PEX16 - Bos taurus (Bovine) - PEX16 gene Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (By similarity). Taurus_UMD|evm.model.AC_000172.1.818 Q8N3Y3 LARG2_HUMAN 89.378 0.946763 0.963939 LARGE2 - LARGE xylosyl- and glucuronyltransferase 2 - Homo sapiens (Human) - LARGE2 gene Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide. Has a higher activity toward alpha-dystroglycan than LARGE. Taurus_UMD|evm.model.AC_000172.1.819 Q96BD5 PF21A_HUMAN 97.222 0.997072 1.00441 PHF21A - PHD finger protein 21A - Homo sapiens (Human) - PHF21A gene Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. Taurus_UMD|evm.model.AC_000172.1.820 Q96BA8 CR3L1_HUMAN 93.846 0.996161 1.00385 CREB3L1 - Cyclic AMP-responsive element-binding protein 3-like protein 1 - Homo sapiens (Human) - CREB3L1 gene Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401). Taurus_UMD|evm.model.AC_000172.1.822 Q13574 DGKZ_HUMAN 82.078 0.997642 0.913793 DGKZ - Diacylglycerol kinase zeta - Homo sapiens (Human) - DGKZ gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PubMed:9159104, PubMed:19744926, PubMed:22108654). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PubMed:15544348, PubMed:19744926, PubMed:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PubMed:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity). Taurus_UMD|evm.model.AC_000172.1.823 P21741 MK_HUMAN 93.750 0.830065 1.06993 MDK - Midkine precursor - Homo sapiens (Human) - MDK gene Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:18469519, PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:24458438, PubMed:15466886, PubMed:12084985, PubMed:10772929). Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups (PubMed:12084985, PubMed:10212223). Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:10683378, PubMed:24458438, PubMed:22323540, PubMed:12084985, PubMed:15466886, PubMed:10772929). Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378, PubMed:24458438). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively (PubMed:10683378). Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (PubMed:22323540). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (By similarity). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (By similarity). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (By similarity). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival (PubMed:10212223). Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion (PubMed:12084985, PubMed:1768439). Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (PubMed:12084985). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (By similarity). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886, PubMed:1768439). Binds LRP1; promotes neuronal survival (PubMed:10772929). Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (PubMed:12122009). Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (PubMed:18469519). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (By similarity). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (By similarity). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity). Taurus_UMD|evm.model.AC_000172.1.824 P08173 ACM4_HUMAN 96.258 0.995842 1.00418 CHRM4 - Muscarinic acetylcholine receptor M4 - Homo sapiens (Human) - CHRM4 gene The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. Taurus_UMD|evm.model.AC_000172.1.825 A2AH22 AMRA1_MOUSE 96.875 0.211093 0.929231 Ambra1 - Activating molecule in BECN1-regulated autophagy protein 1 - Mus musculus (Mouse) - Ambra1 gene Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. Taurus_UMD|evm.model.AC_000172.1.826 Q17QR8 HARB1_BOVIN 100.000 0.994286 1.00287 HARBI1 - Putative nuclease HARBI1 - Bos taurus (Bovine) - HARBI1 gene Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity (By similarity). Taurus_UMD|evm.model.AC_000172.1.827 Q08DY8 ATG13_BOVIN 99.245 0.479129 1.14792 ATG13 - Autophagy-related protein 13 - Bos taurus (Bovine) - ATG13 gene Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. Taurus_UMD|evm.model.AC_000172.1.829 Q07960 RHG01_HUMAN 95.444 0.897541 1.11162 ARHGAP1 - Rho GTPase-activating protein 1 - Homo sapiens (Human) - ARHGAP1 gene GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate. Taurus_UMD|evm.model.AC_000172.1.830 Q9H9D4 ZN408_HUMAN 77.514 0.984722 1 ZNF408 - Zinc finger protein 408 - Homo sapiens (Human) - ZNF408 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000172.1.832 P00735 THRB_BOVIN 100.000 0.996805 1.0016 F2 - Prothrombin precursor - Bos taurus (Bovine) - F2 gene Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). Taurus_UMD|evm.model.AC_000172.1.833 Q14008 CKAP5_HUMAN 96.161 0.999016 1.00049 CKAP5 - Cytoskeleton-associated protein 5 - Homo sapiens (Human) - CKAP5 gene Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). Taurus_UMD|evm.model.AC_000172.1.834 O75096 LRP4_HUMAN 97.564 0.991071 0.999475 LRP4 - Low-density lipoprotein receptor-related protein 4 precursor - Homo sapiens (Human) - LRP4 gene Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity). Taurus_UMD|evm.model.AC_000172.1.835 Q8NGP0 OR4CD_HUMAN 69.707 0.93578 1.05825 OR4C13 - Olfactory receptor 4C13 - Homo sapiens (Human) - OR4C13 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.836 Q8NGL4 OR5DD_HUMAN 66.935 0.854167 0.458599 OR5D13 - Olfactory receptor 5D13 - Homo sapiens (Human) - OR5D13 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.837 Q32KQ7 CK049_BOVIN 99.636 0.825301 1.0184 UPF0705 protein C11orf49 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000172.1.838 A1L520 ARFG2_BOVIN 100.000 0.996161 1.00192 ARFGAP2 - ADP-ribosylation factor GTPase-activating protein 2 - Bos taurus (Bovine) - ARFGAP2 gene GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity). Taurus_UMD|evm.model.AC_000172.1.839 Q9UKS6 PACN3_HUMAN 94.811 0.995261 0.995283 PACSIN3 - Protein kinase C and casein kinase substrate in neurons protein 3 - Homo sapiens (Human) - PACSIN3 gene Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). Taurus_UMD|evm.model.AC_000172.1.840 Q0VBY8 DDB2_BOVIN 100.000 0.995316 1.00235 DDB2 - DNA damage-binding protein 2 - Bos taurus (Bovine) - DDB2 gene Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR. Taurus_UMD|evm.model.AC_000172.1.841 Q0P5F0 PPAL_BOVIN 100.000 0.995283 1.00236 ACP2 - Lysosomal acid phosphatase precursor - Bos taurus (Bovine) - ACP2 gene lysosome, acid phosphatase activity, phosphatase activity, dephosphorylation, lysosome organization Taurus_UMD|evm.model.AC_000172.1.842 Q5E9B6 NR1H3_BOVIN 100.000 0.995536 1.00224 NR1H3 - Oxysterols receptor LXR-alpha - Bos taurus (Bovine) - NR1H3 gene Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Taurus_UMD|evm.model.AC_000172.1.843 O08873 MADD_RAT 91.237 0.998741 0.991261 Madd - MAP kinase-activating death domain protein - Rattus norvegicus (Rat) - Madd gene Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:9020086). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (By similarity). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (PubMed:9020086). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in upregulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (By similarity). May link TNFRSF1A with MAP kinase activation (By similarity). May be involved in the regulation of TNFA-induced apoptosis (By similarity). Taurus_UMD|evm.model.AC_000172.1.844 Q14896 MYPC3_HUMAN 89.490 0.998425 0.99686 MYBPC3 - Myosin-binding protein C, cardiac-type - Homo sapiens (Human) - MYBPC3 gene Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Taurus_UMD|evm.model.AC_000172.1.845 Q6PKU1 SPI1_PIG 95.203 0.99262 1.0037 SPI1 - Transcription factor PU.1 - Sus scrofa (Pig) - SPI1 gene Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). Taurus_UMD|evm.model.AC_000172.1.846 Q96H72 S39AD_HUMAN 88.441 0.994521 0.983827 SLC39A13 - Zinc transporter ZIP13 - Homo sapiens (Human) - SLC39A13 gene Acts as a zinc-influx transporter. Taurus_UMD|evm.model.AC_000172.1.847 P17980 PRS6A_HUMAN 99.317 0.52518 1.89977 PSMC3 - 26S proteasome regulatory subunit 6A - Homo sapiens (Human) - PSMC3 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Taurus_UMD|evm.model.AC_000172.1.849 Q92879 CELF1_HUMAN 98.765 0.654521 1.52469 CELF1 - CUGBP Elav-like family member 1 - Homo sapiens (Human) - CELF1 gene RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233). Taurus_UMD|evm.model.AC_000172.1.850 Q8WUK0 PTPM1_HUMAN 83.333 0.704797 1.34826 PTPMT1 - Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 precursor - Homo sapiens (Human) - PTPMT1 gene Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (PubMed:24709986). Taurus_UMD|evm.model.AC_000172.1.851 Q5R4S6 KBTB4_PONAB 99.228 0.960967 1.03861 KBTBD4 - Kelch repeat and BTB domain-containing protein 4 - Pongo abelii (Sumatran orangutan) - KBTBD4 gene Taurus_UMD|evm.model.AC_000172.1.852 P23709 NDUS3_BOVIN 99.545 0.931915 0.883459 NDUFS3 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial precursor - Bos taurus (Bovine) - NDUFS3 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:18721790, PubMed:10852722). Essential for the catalytic activity and assembly of complex I (By similarity). Taurus_UMD|evm.model.AC_000172.1.853 P23709 NDUS3_BOVIN 100.000 0.701299 0.289474 NDUFS3 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial precursor - Bos taurus (Bovine) - NDUFS3 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:18721790, PubMed:10852722). Essential for the catalytic activity and assembly of complex I (By similarity). Taurus_UMD|evm.model.AC_000172.1.854 Q6P0A1 F180B_HUMAN 85.246 0.90099 1.10383 FAM180B - Protein FAM180B precursor - Homo sapiens (Human) - FAM180B gene Taurus_UMD|evm.model.AC_000172.1.855 Q8R066 C1QT4_MOUSE 89.714 0.882653 0.601227 C1qtnf4 - Complement C1q tumor necrosis factor-related protein 4 precursor - Mus musculus (Mouse) - C1qtnf4 gene May be involved in the regulation of the inflammatory network. The role as pro- or anti-inflammatory seems to be context dependent (By similarity). Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post-injection (Probable). Taurus_UMD|evm.model.AC_000172.1.857 Q9N285 MTCH2_BOVIN 87.755 0.994186 1.13531 MTCH2 - Mitochondrial carrier homolog 2 - Bos taurus (Bovine) - MTCH2 gene The substrate transported is not yet known. Induces mitochondrial depolarization (By similarity). Taurus_UMD|evm.model.AC_000172.1.858 Q8CDK2 CBPC2_MOUSE 65.464 0.463942 0.482599 Agbl2 - Cytosolic carboxypeptidase 2 - Mus musculus (Mouse) - Agbl2 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin. Taurus_UMD|evm.model.AC_000172.1.859 Q5U5Z8 CBPC2_HUMAN 89.764 0.357546 1.57206 AGBL2 - Cytosolic carboxypeptidase 2 - Homo sapiens (Human) - AGBL2 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin. Taurus_UMD|evm.model.AC_000172.1.860 Q12769 NU160_HUMAN 91.726 0.998562 0.968663 NUP160 - Nuclear pore complex protein Nup160 - Homo sapiens (Human) - NUP160 gene Functions as a component of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705). Involved in poly(A)+ RNA transport. Taurus_UMD|evm.model.AC_000172.1.861 Q12913 PTPRJ_HUMAN 94.550 0.345609 0.792072 PTPRJ - Receptor-type tyrosine-protein phosphatase eta precursor - Homo sapiens (Human) - PTPRJ gene Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. Taurus_UMD|evm.model.AC_000172.1.862 Q8NH73 OR4S2_HUMAN 66.225 0.528169 0.913183 OR4S2 - Olfactory receptor 4S2 - Homo sapiens (Human) - OR4S2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.863 Q8NGF8 OR4B1_HUMAN 86.517 0.992537 0.867314 OR4B1 - Olfactory receptor 4B1 - Homo sapiens (Human) - OR4B1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.865 Q8NH49 OR4X1_HUMAN 79.339 0.991736 0.396721 OR4X1 - Olfactory receptor 4X1 - Homo sapiens (Human) - OR4X1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.872 Q8NH37 OR4C3_HUMAN 65.761 0.958115 0.63245 OR4C3 - Olfactory receptor 4C3 - Homo sapiens (Human) - OR4C3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.873 Q8NH37 OR4C3_HUMAN 62.651 0.953757 0.572848 OR4C3 - Olfactory receptor 4C3 - Homo sapiens (Human) - OR4C3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.874 Q8NH37 OR4C3_HUMAN 66.304 0.958115 0.63245 OR4C3 - Olfactory receptor 4C3 - Homo sapiens (Human) - OR4C3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.875 Q0VAX3 FS2P1_MOUSE 71.753 0.983539 0.997947 Fads2b - Fatty acid desaturase 2-like protein FADS2B - Mus musculus (Mouse) - Fads2b gene Taurus_UMD|evm.model.AC_000172.1.877 Q8NH87 OR9G1_HUMAN 65.306 0.813559 0.193443 OR9G1 - Olfactory receptor 9G1 - Homo sapiens (Human) - OR9G1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.878 Q8NGG4 OR8H1_HUMAN 75.000 0.831579 0.305466 OR8H1 - Olfactory receptor 8H1 - Homo sapiens (Human) - OR8H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.879 Q8NGG4 OR8H1_HUMAN 81.081 0.993243 0.475884 OR8H1 - Olfactory receptor 8H1 - Homo sapiens (Human) - OR8H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.881 Q8NH51 OR8K3_HUMAN 84.167 0.983471 0.387821 OR8K3 - Olfactory receptor 8K3 - Homo sapiens (Human) - OR8K3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.883 Q7TR96 O1013_MOUSE 70.330 0.983696 0.603279 Olfr1013 - Olfactory receptor 1013 - Mus musculus (Mouse) - Olfr1013 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.884 P0C617 O5AL1_HUMAN 74.302 0.994413 0.544073 OR5AL1 - Olfactory receptor 5AL1 - Homo sapiens (Human) - OR5AL1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.885 Q8NGP4 OR5M3_HUMAN 91.111 0.988889 0.29316 OR5M3 - Olfactory receptor 5M3 - Homo sapiens (Human) - OR5M3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.886 Q8NGP4 OR5M3_HUMAN 87.603 0.789474 0.495114 OR5M3 - Olfactory receptor 5M3 - Homo sapiens (Human) - OR5M3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.887 Q96RB7 OR5MB_HUMAN 75.510 0.979798 0.32459 OR5M11 - Olfactory receptor 5M11 - Homo sapiens (Human) - OR5M11 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.888 Q6IEU7 OR5MA_HUMAN 67.148 0.99639 0.879365 OR5M10 - Olfactory receptor 5M10 - Homo sapiens (Human) - OR5M10 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.889 Q7TR96 O1013_MOUSE 69.792 0.856502 0.731148 Olfr1013 - Olfactory receptor 1013 - Mus musculus (Mouse) - Olfr1013 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.890 Q0VAX3 FS2P1_MOUSE 73.101 0.987654 0.997947 Fads2b - Fatty acid desaturase 2-like protein FADS2B - Mus musculus (Mouse) - Fads2b gene Taurus_UMD|evm.model.AC_000172.1.891 Q4KLL3 LRC55_RAT 89.262 0.951923 1.04698 Lrrc55 - Leucine-rich repeat-containing protein 55 precursor - Rattus norvegicus (Rat) - Lrrc55 gene Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity). Taurus_UMD|evm.model.AC_000172.1.892 O97666 APJ_MACMU 76.000 0.995012 1.05526 APLNR - Apelin receptor - Macaca mulatta (Rhesus macaque) - APLNR gene Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone. May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure. Taurus_UMD|evm.model.AC_000172.1.893 Q9C0C2 TB182_HUMAN 68.441 0.290141 1.0266 TNKS1BP1 - 182 kDa tankyrase-1-binding protein - Homo sapiens (Human) - TNKS1BP1 gene actin cytoskeleton, adherens junction, CCR4-NOT complex, cytoplasm, cytosol, heterochromatin, nucleus, plasma membrane, ankyrin repeat binding, cadherin binding Taurus_UMD|evm.model.AC_000172.1.894 Q08945 SSRP1_HUMAN 97.099 0.997241 1.02257 SSRP1 - FACT complex subunit SSRP1 - Homo sapiens (Human) - SSRP1 gene Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. Taurus_UMD|evm.model.AC_000172.1.895 P49654 P2RX3_RAT 91.940 0.994975 1.00252 P2rx3 - P2X purinoceptor 3 - Rattus norvegicus (Rat) - P2rx3 gene Receptor for ATP that acts as a ligand-gated cation channel (PubMed:7566120, PubMed:7566119). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity). Taurus_UMD|evm.model.AC_000172.1.896 Q63189 PRG2_RAT 60.667 0.675799 0.964758 Prg2 - Bone marrow proteoglycan precursor - Rattus norvegicus (Rat) - Prg2 gene Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity). Taurus_UMD|evm.model.AC_000172.1.897 Q9Y2Y8 PRG3_HUMAN 56.338 0.936073 0.973333 PRG3 - Proteoglycan 3 precursor - Homo sapiens (Human) - PRG3 gene Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. Taurus_UMD|evm.model.AC_000172.1.898 Q9JL95 PRG3_MOUSE 52.444 0.990476 0.945946 Prg3 - Proteoglycan 3 precursor - Mus musculus (Mouse) - Prg3 gene Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. Taurus_UMD|evm.model.AC_000172.1.899 Q9Y2Y8 PRG3_HUMAN 56.338 0.936652 0.982222 PRG3 - Proteoglycan 3 precursor - Homo sapiens (Human) - PRG3 gene Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. Taurus_UMD|evm.model.AC_000172.1.900 Q1JPD8 S43A3_BOVIN 99.182 0.995918 1.00204 SLC43A3 - Solute carrier family 43 member 3 - Bos taurus (Bovine) - SLC43A3 gene Putative transporter. Taurus_UMD|evm.model.AC_000172.1.901 Q86UN3 R4RL2_HUMAN 91.935 0.953728 0.92619 RTN4RL2 - Reticulon-4 receptor-like 2 precursor - Homo sapiens (Human) - RTN4RL2 gene Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). Taurus_UMD|evm.model.AC_000172.1.902 O75387 LAT3_HUMAN 80.347 0.743243 0.397138 SLC43A1 - Large neutral amino acids transporter small subunit 3 - Homo sapiens (Human) - SLC43A1 gene Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. Taurus_UMD|evm.model.AC_000172.1.903 Q8BSM7 LAT3_MOUSE 80.412 0.973064 0.526596 Slc43a1 - Large neutral amino acids transporter small subunit 3 - Mus musculus (Mouse) - Slc43a1 gene Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine (By similarity). Taurus_UMD|evm.model.AC_000172.1.904 Q5RCR3 RL4_PONAB 79.310 0.982456 0.266979 RPL4 - 60S ribosomal protein L4 - Pongo abelii (Sumatran orangutan) - RPL4 gene Taurus_UMD|evm.model.AC_000172.1.905 Q2NKR1 TIM10_BOVIN 100.000 0.154412 6.04444 TIMM10 - Mitochondrial import inner membrane translocase subunit Tim10 - Bos taurus (Bovine) - TIMM10 gene Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). Taurus_UMD|evm.model.AC_000172.1.906 A5PJC4 UB2L6_BOVIN 100.000 0.987013 1.00654 UBE2L6 - Ubiquitin/ISG15-conjugating enzyme E2 L6 - Bos taurus (Bovine) - UBE2L6 gene Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. Taurus_UMD|evm.model.AC_000172.1.907 P50448 F12AI_BOVIN 99.145 0.995736 1.00214 Factor XIIa inhibitor precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000172.1.909 Q5XID5 YPEL4_RAT 98.765 0.733945 0.858268 Ypel4 - Protein yippee-like 4 - Rattus norvegicus (Rat) - Ypel4 gene Taurus_UMD|evm.model.AC_000172.1.910 A2VE01 CLP1_BOVIN 100.000 0.995305 1.00235 CLP1 - Polyribonucleotide 5'-hydroxyl-kinase Clp1 - Bos taurus (Bovine) - CLP1 gene Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity). Taurus_UMD|evm.model.AC_000172.1.911 O60716 CTND1_HUMAN 95.624 0.995713 0.963843 CTNND1 - Catenin delta-1 - Homo sapiens (Human) - CTNND1 gene Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). Taurus_UMD|evm.model.AC_000172.1.912 E1BLT8 ZDHC5_BOVIN 100.000 0.997203 1.0014 ZDHHC5 - Palmitoyltransferase ZDHHC5 - Bos taurus (Bovine) - ZDHHC5 gene Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Palmitoylates the G-protein coupled receptor SSTR5 and for FLOT2. Taurus_UMD|evm.model.AC_000172.1.913 A0JLT2 MED19_HUMAN 95.082 0.991837 1.0041 MED19 - Mediator of RNA polymerase II transcription subunit 19 - Homo sapiens (Human) - MED19 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Taurus_UMD|evm.model.AC_000172.1.914 Q2TBU2 TMX2_BOVIN 100.000 0.993266 1.00338 TMX2 - Thioredoxin-related transmembrane protein 2 precursor - Bos taurus (Bovine) - TMX2 gene Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain. Taurus_UMD|evm.model.AC_000172.1.915 Q8IZQ5 SELH_HUMAN 71.545 0.981818 0.901639 SELENOH - Selenoprotein H - Homo sapiens (Human) - SELENOH gene May be involved in a redox-related process. Taurus_UMD|evm.model.AC_000172.1.916 B2RXH4 BTBDI_HUMAN 73.615 0.970085 0.985955 BTBD18 - BTB/POZ domain-containing protein 18 - Homo sapiens (Human) - BTBD18 gene Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene. Taurus_UMD|evm.model.AC_000172.1.917 Q8VF13 O1094_MOUSE 45.455 0.768707 0.445455 Olfr1094 - Olfactory receptor 1094 - Mus musculus (Mouse) - Olfr1094 gene Potential odorant receptor. Taurus_UMD|evm.model.AC_000172.1.922 Q17QF2 EFMT1_BOVIN 79.630 0.726027 0.323009 EEF1AKMT1 - EEF1A lysine methyltransferase 1 - Bos taurus (Bovine) - EEF1AKMT1 gene Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'. Taurus_UMD|evm.model.AC_000172.1.923 Q8NGF6 O10W1_HUMAN 71.429 0.621622 0.363934 OR10W1 - Olfactory receptor 10W1 - Homo sapiens (Human) - OR10W1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.925 Q96R08 OR5BC_HUMAN 74.576 0.993243 0.942675 OR5B12 - Olfactory receptor 5B12 - Homo sapiens (Human) - OR5B12 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.928 Q96R09 OR5B2_HUMAN 79.402 0.967742 1.00324 OR5B2 - Olfactory receptor 5B2 - Homo sapiens (Human) - OR5B2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000172.1.931 Q9N261 LPXN_RABIT 86.327 0.75 1.28497 LPXN - Leupaxin - Oryctolagus cuniculus (Rabbit) - LPXN gene Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling (By similarity). Taurus_UMD|evm.model.AC_000172.1.932 Q96JP5 ZFP91_HUMAN 86.736 0.996409 0.977193 ZFP91 - E3 ubiquitin-protein ligase ZFP91 - Homo sapiens (Human) - ZFP91 gene Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. Taurus_UMD|evm.model.AC_000172.1.933 O02732 CNTF_PIG 78.000 0.99 1 CNTF - Ciliary neurotrophic factor - Sus scrofa (Pig) - CNTF gene CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity). Taurus_UMD|evm.model.AC_000172.1.934 Q5RBP9 MPEG1_PONAB 39.917 0.948276 1.05307 MPEG1 - Macrophage-expressed gene 1 protein precursor - Pongo abelii (Sumatran orangutan) - MPEG1 gene Plays a key role in the innate immune response following bacterial infection by polymerizing and inserting into the bacterial surface to form pores (By similarity). By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence (By similarity). Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria (By similarity). Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity). Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity). Taurus_UMD|evm.model.AC_000172.1.935 Q6IB77 GLYAT_HUMAN 71.186 0.993243 1 GLYAT - Glycine N-acyltransferase - Homo sapiens (Human) - GLYAT gene Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. Taurus_UMD|evm.model.AC_000172.1.936 Q2KIR7 GLYAT_BOVIN 64.169 0.992366 0.888136 GLYAT - Glycine N-acyltransferase - Bos taurus (Bovine) - GLYAT gene Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. Taurus_UMD|evm.model.AC_000172.1.937 Q2KIR7 GLYAT_BOVIN 99.661 0.989899 1.00678 GLYAT - Glycine N-acyltransferase - Bos taurus (Bovine) - GLYAT gene Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. Taurus_UMD|evm.model.AC_000172.1.938 O77512 GLYAL_BOVIN 100.000 0.551595 1.80678 Glycine N-phenylacetyltransferase - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000172.1.939 Q6SJ93 F111B_HUMAN 62.803 0.837714 1.1921 FAM111B - Serine protease FAM111B - Homo sapiens (Human) - FAM111B gene Serine protease. Taurus_UMD|evm.model.AC_000172.1.940 Q9Y2E6 DTX4_HUMAN 93.973 0.658228 0.893376 DTX4 - E3 ubiquitin-protein ligase DTX4 - Homo sapiens (Human) - DTX4 gene Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. Taurus_UMD|evm.model.AC_000172.1.941 Q2KJC3 MPEG1_BOVIN 100.000 0.997214 1.00139 MPEG1 - Macrophage-expressed gene 1 protein precursor - Bos taurus (Bovine) - MPEG1 gene Plays a key role in the innate immune response following bacterial infection by polymerizing and inserting into the bacterial surface to form pores (By similarity). By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence (By similarity). Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria (By similarity). Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity). Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity). Taurus_UMD|evm.model.AC_000172.1.943 Q9NP64 NO40_HUMAN 95.067 0.932773 0.987552 ZCCHC17 - Nucleolar protein of 40 kDa - Homo sapiens (Human) - ZCCHC17 gene identical protein binding, RNA binding, RNA stabilization Taurus_UMD|evm.model.AC_000172.1.944 P16258 OSBP1_RABIT 94.935 0.980085 0.868974 OSBP - Oxysterol-binding protein 1 - Oryctolagus cuniculus (Rabbit) - OSBP gene Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:18165705). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (By similarity). Regulates cholesterol efflux by decreasing ABCA1 stability (By similarity). Taurus_UMD|evm.model.AC_000172.1.945 Q5R8Q4 PATL1_PONAB 95.979 0.997409 1.0026 PATL1 - Protein PAT1 homolog 1 - Pongo abelii (Sumatran orangutan) - PATL1 gene RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. Taurus_UMD|evm.model.AC_000172.1.947 Q08849 STX3_RAT 95.105 0.7125 1.38408 Stx3 - Syntaxin-3 - Rattus norvegicus (Rat) - Stx3 gene Potentially involved in docking of synaptic vesicles at presynaptic active zones. Taurus_UMD|evm.model.AC_000172.1.948 Q3T0J3 RM16_BOVIN 100.000 0.992063 1.00398 MRPL16 - 39S ribosomal protein L16, mitochondrial precursor - Bos taurus (Bovine) - MRPL16 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, rRNA binding, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000172.1.949 P27352 IF_HUMAN 78.417 0.995215 1.0024 CBLIF - Cobalamin binding intrinsic factor precursor - Homo sapiens (Human) - CBLIF gene Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis. Taurus_UMD|evm.model.AC_000172.1.950 P20061 TCO1_HUMAN 62.125 0.995327 0.988453 TCN1 - Transcobalamin-1 precursor - Homo sapiens (Human) - TCN1 gene Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach. Taurus_UMD|evm.model.AC_000172.1.951 Q2Q0J1 OOSP1_BOVIN 97.674 0.345013 2.27607 OOSP1 - Oocyte-secreted protein 1 precursor - Bos taurus (Bovine) - OOSP1 gene May be involved in cell differentiation. Taurus_UMD|evm.model.AC_000172.1.952 Q9GZW8 MS4A7_HUMAN 69.192 0.328308 2.4875 MS4A7 - Membrane-spanning 4-domains subfamily A member 7 - Homo sapiens (Human) - MS4A7 gene May be involved in signal transduction as a component of a multimeric receptor complex. Taurus_UMD|evm.model.AC_000172.1.953 Q96JA4 M4A14_HUMAN 42.040 0.748786 1.21355 MS4A14 - Membrane-spanning 4-domains subfamily A member 14 - Homo sapiens (Human) - MS4A14 gene May be involved in signal transduction as a component of a multimeric receptor complex. Taurus_UMD|evm.model.AC_000172.1.954 Q9H3V2 MS4A5_HUMAN 62.626 0.960976 1.025 MS4A5 - Membrane-spanning 4-domains subfamily A member 5 - Homo sapiens (Human) - MS4A5 gene May be involved in signal transduction as a component of a multimeric receptor complex. Taurus_UMD|evm.model.AC_000172.1.955 Q3C2E2 CD20_CANLF 66.447 0.992908 0.949495 MS4A1 - B-lymphocyte antigen CD20 - Canis lupus familiaris (Dog) - MS4A1 gene B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR. Taurus_UMD|evm.model.AC_000172.1.956 Q2YDM3 M4A13_BOVIN 99.346 0.858757 1.15686 MS4A13 - Membrane-spanning 4-domains subfamily A member 13 - Bos taurus (Bovine) - MS4A13 gene May be involved in signal transduction as a component of a multimeric receptor complex. Taurus_UMD|evm.model.AC_000172.1.957 Q9NXJ0 M4A12_HUMAN 33.103 0.879747 0.59176 MS4A12 - Membrane-spanning 4-domains subfamily A member 12 - Homo sapiens (Human) - MS4A12 gene May be involved in signal transduction as a component of a multimeric receptor complex. Taurus_UMD|evm.model.AC_000172.1.958 Q96JA4 M4A14_HUMAN 43.662 0.360825 0.285714 MS4A14 - Membrane-spanning 4-domains subfamily A member 14 - Homo sapiens (Human) - MS4A14 gene May be involved in signal transduction as a component of a multimeric receptor complex. Taurus_UMD|evm.model.AC_000172.1.959 P42695 CNDD3_HUMAN 64.003 0.998651 0.989987 NCAPD3 - Condensin-2 complex subunit D3 - Homo sapiens (Human) - NCAPD3 gene Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). Taurus_UMD|evm.model.AC_000172.1.960 Q8C0E2 VP26B_MOUSE 92.727 0.916667 1.03571 Vps26b - Vacuolar protein sorting-associated protein 26B - Mus musculus (Mouse) - Vps26b gene Acts as component of the retromer cargo-selective complex (CSC) (PubMed:21040701, PubMed:21920005). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (By similarity). May be involved in retrograde transport of SORT1 but not of IGF2R (PubMed:21040701). Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (PubMed:25136126). Taurus_UMD|evm.model.AC_000172.1.962 Q9P016 THYN1_HUMAN 77.778 0.991071 0.995556 THYN1 - Thymocyte nuclear protein 1 - Homo sapiens (Human) - THYN1 gene Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Taurus_UMD|evm.model.AC_000172.1.963 Q0NXR6 ACAD8_BOVIN 99.760 0.995204 1.0024 ACAD8 - Isobutyryl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ACAD8 gene Isobutyryl-CoA dehydrogenase which catalyzes one of the steps of the valine catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA. Taurus_UMD|evm.model.AC_000172.1.964 Q8NCI6 GLBL3_HUMAN 68.500 0.426942 2.14855 GLB1L3 - Beta-galactosidase-1-like protein 3 - Homo sapiens (Human) - GLB1L3 gene vacuole, beta-galactosidase activity Taurus_UMD|evm.model.AC_000172.1.965 Q8IW92 GLBL2_HUMAN 73.385 0.995399 1.02516 GLB1L2 - Beta-galactosidase-1-like protein 2 precursor - Homo sapiens (Human) - GLB1L2 gene vacuole, beta-galactosidase activity Taurus_UMD|evm.model.AC_000172.1.966 Q9P2W7 B3GA1_HUMAN 82.369 0.960212 1.12874 B3GAT1 - Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 - Homo sapiens (Human) - B3GAT1 gene Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. Taurus_UMD|evm.model.AC_000172.1.969 P19437 CD20_MOUSE 36.792 0.597701 0.597938 Ms4a1 - B-lymphocyte antigen CD20 - Mus musculus (Mouse) - Ms4a1 gene B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR. Taurus_UMD|evm.model.AC_000173.1.3 Q8VFK7 O1020_MOUSE 52.740 0.99635 0.864353 Olfr1020 - Olfactory receptor 1020 - Mus musculus (Mouse) - Olfr1020 gene Potential odorant receptor. Taurus_UMD|evm.model.AC_000173.1.7 Q8NH19 O10AG_HUMAN 71.084 0.987952 0.275748 OR10AG1 - Olfactory receptor 10AG1 - Homo sapiens (Human) - OR10AG1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000173.1.9 Q5EA86 TM183_BOVIN 100.000 0.994695 1.00266 TMEM183 - Transmembrane protein 183 - Bos taurus (Bovine) - TMEM183 gene Taurus_UMD|evm.model.AC_000173.1.11 O75335 LIPA4_HUMAN 86.326 0.998325 1.00759 PPFIA4 - Liprin-alpha-4 - Homo sapiens (Human) - PPFIA4 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity). Taurus_UMD|evm.model.AC_000173.1.13 Q7YS81 MYOG_BOVIN 100.000 0.892 1.11607 MYOG - Myogenin - Bos taurus (Bovine) - MYOG gene Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity). Taurus_UMD|evm.model.AC_000173.1.14 O47705 COX3_EUDRU 97.531 0.97561 0.314176 MT-CO3 - Cytochrome c oxidase subunit 3 - Eudorcas rufifrons (Red-fronted gazelle) - MT-CO3 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000173.1.15 P28190 AA1R_BOVIN 100.000 0.993884 1.00307 ADORA1 - Adenosine receptor A1 - Bos taurus (Bovine) - ADORA1 gene Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Taurus_UMD|evm.model.AC_000173.1.16 Q13203 MYBPH_HUMAN 80.368 0.995918 1.02725 MYBPH - Myosin-binding protein H - Homo sapiens (Human) - MYBPH gene Binds to myosin; probably involved in interaction with thick myofilaments in the A-band. Taurus_UMD|evm.model.AC_000173.1.17 P30922 CH3L1_BOVIN 99.217 0.97449 1.0235 CHI3L1 - Chitinase-3-like protein 1 precursor - Bos taurus (Bovine) - CHI3L1 gene Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity). Taurus_UMD|evm.model.AC_000173.1.18 Q13231 CHIT1_HUMAN 77.778 0.622378 0.306867 CHIT1 - Chitotriosidase-1 precursor - Homo sapiens (Human) - CHIT1 gene Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity. Taurus_UMD|evm.model.AC_000173.1.19 Q4R7Y2 RL10_MACFA 77.778 0.820652 0.859813 RPL10 - 60S ribosomal protein L10 - Macaca fascicularis (Crab-eating macaque) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000173.1.20 Q04211 BTG2_MOUSE 93.333 0.986755 0.955696 Btg2 - Protein BTG2 - Mus musculus (Mouse) - Btg2 gene Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth (By similarity). Taurus_UMD|evm.model.AC_000173.1.21 P13605 FMOD_BOVIN 100.000 0.899281 1.10904 FMOD - Fibromodulin precursor - Bos taurus (Bovine) - FMOD gene Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). Taurus_UMD|evm.model.AC_000173.1.22 Q9GKN8 PRELP_BOVIN 99.475 0.994764 1.00262 PRELP - Prolargin precursor - Bos taurus (Bovine) - PRELP gene May anchor basement membranes to the underlying connective tissue. Taurus_UMD|evm.model.AC_000173.1.23 P58874 OPT_BOVIN 100.000 0.993789 1.00312 OPTC - Opticin precursor - Bos taurus (Bovine) - OPTC gene Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (PubMed:12951322, PubMed:10636917). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). Taurus_UMD|evm.model.AC_000173.1.24 D3K0R6 AT2B4_BOVIN 99.639 0.582632 1.57415 ATP2B4 - Plasma membrane calcium-transporting ATPase 4 - Bos taurus (Bovine) - ATP2B4 gene Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (By similarity). By regulating sperm cells calcium homeostasis, may play a role in sperm motility (By similarity). Taurus_UMD|evm.model.AC_000173.1.25 P86452 ZBED6_HUMAN 90.224 0.997961 1.00204 ZBED6 - Zinc finger BED domain-containing protein 6 - Homo sapiens (Human) - ZBED6 gene Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific (By similarity). Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP (By similarity). Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females (By similarity). Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription (By similarity). Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2 (By similarity). Positively regulates the cell cycle and survival of pancreatic beta cells (PubMed:24043816). Binds to the CDH2 gene and may directly repress CDH2 transcription (By similarity). Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells (By similarity). May also play a role in embryonic beta cell differentiation (By similarity). May play a role in insulin sensitivity and glucose clearance (By similarity). Taurus_UMD|evm.model.AC_000173.1.26 O75152 ZC11A_HUMAN 83.599 0.997552 1.00864 ZC3H11A - Zinc finger CCCH domain-containing protein 11A - Homo sapiens (Human) - ZC3H11A gene RNA-binding protein that interacts with purine-rich sequences and is involved in nuclear mRNA export; probably mediated by association with the TREX complex. Taurus_UMD|evm.model.AC_000173.1.27 P62305 RUXE_MOUSE 100.000 0.978495 1.01087 Snrpe - Small nuclear ribonucleoprotein E - Mus musculus (Mouse) - Snrpe gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. Taurus_UMD|evm.model.AC_000173.1.28 Q9UN79 SOX13_HUMAN 88.320 0.996805 1.00643 SOX13 - Transcription factor SOX-13 - Homo sapiens (Human) - SOX13 gene Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). Taurus_UMD|evm.model.AC_000173.1.29 Q9NVF9 EKI2_HUMAN 91.333 0.92284 0.839378 ETNK2 - Ethanolamine kinase 2 - Homo sapiens (Human) - ETNK2 gene Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity). Taurus_UMD|evm.model.AC_000173.1.30 P52115 RENI_SHEEP 96.010 0.994987 0.9975 REN - Renin precursor - Ovis aries (Sheep) - REN gene Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Taurus_UMD|evm.model.AC_000173.1.31 Q2NKV8 GOT1A_BOVIN 100.000 0.404762 2.22727 GOLT1A - Vesicle transport protein GOT1A - Bos taurus (Bovine) - GOLT1A gene May be involved in fusion of ER-derived transport vesicles with the Golgi complex. Taurus_UMD|evm.model.AC_000173.1.33 Q9Y2H5 PKHA6_HUMAN 86.351 0.998182 1.04962 PLEKHA6 - Pleckstrin homology domain-containing family A member 6 - Homo sapiens (Human) - PLEKHA6 gene Taurus_UMD|evm.model.AC_000173.1.35 Q5SWA1 PR15B_HUMAN 73.633 0.997139 0.980365 PPP1R15B - Protein phosphatase 1 regulatory subunit 15B - Homo sapiens (Human) - PPP1R15B gene Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. Taurus_UMD|evm.model.AC_000173.1.36 O00750 P3C2B_HUMAN 93.084 0.998769 0.994492 PIK3C2B - Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta - Homo sapiens (Human) - PIK3C2B gene Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:9830063, PubMed:11533253). Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725). Taurus_UMD|evm.model.AC_000173.1.38 Q2HJ21 MDM4_BOVIN 99.593 0.995935 1.00204 MDM4 - Protein Mdm4 - Bos taurus (Bovine) - MDM4 gene Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity). Taurus_UMD|evm.model.AC_000173.1.39 A0A075B6N1 TVB19_HUMAN 69.369 0.486726 1.98246 TRBV19 - T cell receptor beta variable 19 precursor - Homo sapiens (Human) - TRBV19 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.AC_000173.1.40 O75325 LRRN2_HUMAN 93.268 0.997195 1 LRRN2 - Leucine-rich repeat neuronal protein 2 precursor - Homo sapiens (Human) - LRRN2 gene extracellular matrix, extracellular space, signaling receptor activity, cell adhesion, signal transduction Taurus_UMD|evm.model.AC_000173.1.42 O94856 NFASC_HUMAN 94.061 0.924739 1.06533 NFASC - Neurofascin precursor - Homo sapiens (Human) - NFASC gene Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Taurus_UMD|evm.model.AC_000173.1.45 Q02246 CNTN2_HUMAN 91.250 0.998079 1.00096 CNTN2 - Contactin-2 precursor - Homo sapiens (Human) - CNTN2 gene In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion. Taurus_UMD|evm.model.AC_000173.1.46 Q0VCB1 TMM81_BOVIN 99.638 0.99278 1.00362 TMEM81 - Transmembrane protein 81 precursor - Bos taurus (Bovine) - TMEM81 gene Taurus_UMD|evm.model.AC_000173.1.47 Q15291 RBBP5_HUMAN 100.000 0.996289 1.00186 RBBP5 - Retinoblastoma-binding protein 5 - Homo sapiens (Human) - RBBP5 gene In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). Does not affect ES cell self-renewal (By similarity). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (PubMed:19556245). Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:19556245). In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:22266653, PubMed:21220120). Taurus_UMD|evm.model.AC_000173.1.48 Q4TVR5 DUSTY_BOVIN 100.000 0.997847 1.00108 DSTYK - Dual serine/threonine and tyrosine protein kinase - Bos taurus (Bovine) - DSTYK gene Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. Taurus_UMD|evm.model.AC_000173.1.49 Q80W04 TMCC2_MOUSE 74.825 0.807471 0.492918 Tmcc2 - Transmembrane and coiled-coil domains protein 2 - Mus musculus (Mouse) - Tmcc2 gene May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. Taurus_UMD|evm.model.AC_000173.1.50 O75069 TMCC2_HUMAN 93.534 0.968619 0.674189 TMCC2 - Transmembrane and coiled-coil domains protein 2 - Homo sapiens (Human) - TMCC2 gene May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. Taurus_UMD|evm.model.AC_000173.1.51 Q9H093 NUAK2_HUMAN 83.721 0.996899 1.02707 NUAK2 - NUAK family SNF1-like kinase 2 - Homo sapiens (Human) - NUAK2 gene Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1. Taurus_UMD|evm.model.AC_000173.1.52 Q8IYD2 KLD8A_HUMAN 94.737 0.941909 0.688571 KLHDC8A - Kelch domain-containing protein 8A - Homo sapiens (Human) - KLHDC8A gene Taurus_UMD|evm.model.AC_000173.1.53 Q8IYD2 KLD8A_HUMAN 96.000 0.939394 0.377143 KLHDC8A - Kelch domain-containing protein 8A - Homo sapiens (Human) - KLHDC8A gene Taurus_UMD|evm.model.AC_000173.1.54 Q68G75 LEMD1_HUMAN 79.412 0.905405 0.40884 LEMD1 - LEM domain-containing protein 1 - Homo sapiens (Human) - LEMD1 gene Taurus_UMD|evm.model.AC_000173.1.55 Q5RD01 CDK18_PONAB 91.966 0.715805 1.38819 CDK18 - Cyclin-dependent kinase 18 - Pongo abelii (Sumatran orangutan) - CDK18 gene May play a role in signal transduction cascades in terminally differentiated cells. Taurus_UMD|evm.model.AC_000173.1.57 Q5RCN7 MFD4A_PONAB 87.821 0.946721 0.949416 MFSD4A - Major facilitator superfamily domain-containing protein 4A - Pongo abelii (Sumatran orangutan) - MFSD4A gene Taurus_UMD|evm.model.AC_000173.1.58 P28324 ELK4_HUMAN 90.046 0.995381 1.00464 ELK4 - ETS domain-containing protein Elk-4 - Homo sapiens (Human) - ELK4 gene Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. Taurus_UMD|evm.model.AC_000173.1.59 Q96JT2 S45A3_HUMAN 89.130 0.994555 0.996383 SLC45A3 - Solute carrier family 45 member 3 - Homo sapiens (Human) - SLC45A3 gene membrane, plasma membrane, sucrose:proton symporter activity, hexose transmembrane transport, positive regulation of fatty acid biosynthetic process, positive regulation of glucose metabolic process, regulation of oligodendrocyte differentiation, sucrose transport Taurus_UMD|evm.model.AC_000173.1.60 Q29S11 NUCKS_BOVIN 100.000 0.991803 1.00412 NUCKS1 - Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 - Bos taurus (Bovine) - NUCKS1 gene Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1. Taurus_UMD|evm.model.AC_000173.1.61 Q91YQ1 RAB7L_MOUSE 94.608 0.990196 1 Rab29 - Ras-related protein Rab-7L1 - Mus musculus (Mouse) - Rab29 gene The small GTPases Rab are key regulators in vesicle trafficking (By similarity). Essential for maintaining the integrity of endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity). Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Regulates also neuronal process morphology in the intact central nervous system (CNS) (By similarity). Taurus_UMD|evm.model.AC_000173.1.62 Q5R839 S41A1_PONAB 96.498 0.996117 1.0039 SLC41A1 - Solute carrier family 41 member 1 - Pongo abelii (Sumatran orangutan) - SLC41A1 gene Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane. Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump. Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (By similarity). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity). Taurus_UMD|evm.model.AC_000173.1.63 Q2T9M7 P20D1_BOVIN 99.205 0.996032 1.00199 PM20D1 - N-fatty-acyl-amino acid synthase/hydrolase PM20D1 precursor - Bos taurus (Bovine) - PM20D1 gene Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles. Taurus_UMD|evm.model.AC_000173.1.64 Q7LBE3 S26A9_HUMAN 89.691 0.941392 1.0354 SLC26A9 - Solute carrier family 26 member 9 - Homo sapiens (Human) - SLC26A9 gene DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport (PubMed:11834742). Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion (PubMed:15800055). May prefer chloride anions and mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane (By similarity). Taurus_UMD|evm.model.AC_000173.1.65 Q08DE8 RAB7B_BOVIN 100.000 0.39939 1.64 RAB7B - Ras-related protein Rab-7b - Bos taurus (Bovine) - RAB7B gene Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway (By similarity). Taurus_UMD|evm.model.AC_000173.1.66 P14091 CATE_HUMAN 45.283 0.403101 0.325758 CTSE - Cathepsin E precursor - Homo sapiens (Human) - CTSE gene May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. Taurus_UMD|evm.model.AC_000173.1.68 Q6ZWK4 RHEX_HUMAN 65.318 0.988506 1.01163 RHEX - Regulator of hemoglobinization and erythroid cell expansion protein - Homo sapiens (Human) - RHEX gene Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation (PubMed:25092874). Taurus_UMD|evm.model.AC_000173.1.69 P47901 V1BR_HUMAN 79.812 0.995294 1.00236 AVPR1B - Vasopressin V1b receptor - Homo sapiens (Human) - AVPR1B gene Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000173.1.70 P0DMP2 SRG2B_HUMAN 98.894 0.420709 2.34061 SRGAP2B - SLIT-ROBO Rho GTPase-activating protein 2B - Homo sapiens (Human) - SRGAP2B gene May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2. Taurus_UMD|evm.model.AC_000173.1.71 Q14164 IKKE_HUMAN 88.022 0.997218 1.00419 IKBKE - Inhibitor of nuclear factor kappa-B kinase subunit epsilon - Homo sapiens (Human) - IKBKE gene Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. Taurus_UMD|evm.model.AC_000173.1.72 Q8WWW0 RASF5_HUMAN 82.234 0.745247 0.629187 RASSF5 - Ras association domain-containing protein 5 - Homo sapiens (Human) - RASSF5 gene Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. Taurus_UMD|evm.model.AC_000173.1.73 Q8WWW0 RASF5_HUMAN 91.189 0.849624 0.636364 RASSF5 - Ras association domain-containing protein 5 - Homo sapiens (Human) - RASSF5 gene Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. Taurus_UMD|evm.model.AC_000173.1.74 Q58CR3 EIF2D_BOVIN 98.618 0.870427 1.13299 EIF2D - Eukaryotic translation initiation factor 2D - Bos taurus (Bovine) - EIF2D gene Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity). Taurus_UMD|evm.model.AC_000173.1.75 O43781 DYRK3_HUMAN 92.857 0.996599 1 DYRK3 - Dual specificity tyrosine-phosphorylation-regulated kinase 3 - Homo sapiens (Human) - DYRK3 gene Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (PubMed:29973724). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:9748265, PubMed:29634919). Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (PubMed:29973724). Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 (PubMed:29973724). Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis (PubMed:29973724). Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling (PubMed:23415227). When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling (PubMed:23415227). Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis (PubMed:10779429). Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (PubMed:10779429). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603). Taurus_UMD|evm.model.AC_000173.1.76 P49136 MAPK2_CRILO 98.176 0.801956 1.24316 MAPKAPK2 - MAP kinase-activated protein kinase 2 - Cricetulus longicaudatus (Long-tailed dwarf hamster) - MAPKAPK2 gene Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress following ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Taurus_UMD|evm.model.AC_000173.1.77 P43480 IL10_BOVIN 100.000 0.972222 1.01124 IL10 - Interleukin-10 precursor - Bos taurus (Bovine) - IL10 gene Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity). Taurus_UMD|evm.model.AC_000173.1.78 Q9UHD0 IL19_HUMAN 78.082 0.905063 0.892655 IL19 - Interleukin-19 precursor - Homo sapiens (Human) - IL19 gene May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity). Taurus_UMD|evm.model.AC_000173.1.79 Q9NYY1 IL20_HUMAN 75.000 0.539286 1.59091 IL20 - Interleukin-20 precursor - Homo sapiens (Human) - IL20 gene Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3. Taurus_UMD|evm.model.AC_000173.1.80 P81265 PIGR_BOVIN 98.811 0.997361 1.00132 PIGR - Polymeric immunoglobulin receptor precursor - Bos taurus (Bovine) - PIGR gene Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. Taurus_UMD|evm.model.AC_000173.1.81 Q8WWV6 FCAMR_HUMAN 51.116 0.935039 0.954887 FCAMR - High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor precursor - Homo sapiens (Human) - FCAMR gene Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM. Taurus_UMD|evm.model.AC_000173.1.82 O60667 FAIM3_HUMAN 65.087 0.952381 1.07692 FCMR - Fas apoptotic inhibitory molecule 3 precursor - Homo sapiens (Human) - FCMR gene May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. Taurus_UMD|evm.model.AC_000173.1.83 Q13007 IL24_HUMAN 68.085 0.945578 0.713592 IL24 - Interleukin-24 precursor - Homo sapiens (Human) - IL24 gene Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation. Taurus_UMD|evm.model.AC_000173.1.84 A5D7K1 SARG_BOVIN 100.000 0.996656 1.00168 SARG - Specifically androgen-regulated gene protein - Bos taurus (Bovine) - SARG gene Putative androgen-specific receptor. Taurus_UMD|evm.model.AC_000173.1.85 Q05B57 OTU1_BOVIN 100.000 0.994269 1.00287 YOD1 - Ubiquitin thioesterase OTU1 - Bos taurus (Bovine) - YOD1 gene Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation. Taurus_UMD|evm.model.AC_000173.1.86 P26285 F262_BOVIN 100.000 0.996241 1.00188 PFKFB2 - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 - Bos taurus (Bovine) - PFKFB2 gene Synthesis and degradation of fructose 2,6-bisphosphate. Taurus_UMD|evm.model.AC_000173.1.87 Q28066 C4BPB_BOVIN 99.495 0.98995 1.00505 C4BPB - C4b-binding protein beta chain precursor - Bos taurus (Bovine) - C4BPB gene Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with serum amyloid P component. Taurus_UMD|evm.model.AC_000173.1.88 Q28065 C4BPA_BOVIN 98.974 0.957377 1 C4BPA - C4b-binding protein alpha chain precursor - Bos taurus (Bovine) - C4BPA gene Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. Taurus_UMD|evm.model.AC_000173.1.89 P04003 C4BPA_HUMAN 53.750 0.811224 0.328308 C4BPA - C4b-binding protein alpha chain precursor - Homo sapiens (Human) - C4BPA gene Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. Taurus_UMD|evm.model.AC_000173.1.90 P08174 DAF_HUMAN 58.586 0.533454 1.45144 CD55 - Complement decay-accelerating factor precursor - Homo sapiens (Human) - CD55 gene This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). Taurus_UMD|evm.model.AC_000173.1.91 P20023 CR2_HUMAN 63.902 0.735758 1.41045 CR2 - Complement receptor type 2 precursor - Homo sapiens (Human) - CR2 gene Receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU (PubMed:7753047). Participates in B lymphocytes activation (PubMed:7753047). Taurus_UMD|evm.model.AC_000173.1.93 Q28085 CFAH_BOVIN 58.117 0.866261 0.266181 CFH - Complement factor H precursor - Bos taurus (Bovine) - CFH gene Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. Taurus_UMD|evm.model.AC_000173.1.94 Q28085 CFAH_BOVIN 91.453 0.93246 0.802589 CFH - Complement factor H precursor - Bos taurus (Bovine) - CFH gene Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. Taurus_UMD|evm.model.AC_000173.1.95 Q6UVM3 KCNT2_HUMAN 98.481 0.768257 0.904846 KCNT2 - Potassium channel subfamily T member 2 - Homo sapiens (Human) - KCNT2 gene Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels (PubMed:14684870, PubMed:16687497, PubMed:29069600). Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (PubMed:16687497) (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRM1 (PubMed:16687497). Taurus_UMD|evm.model.AC_000173.1.108 Q6U7Q0 ZN322_HUMAN 90.769 0.984733 0.325871 ZNF322 - Zinc finger protein 322 - Homo sapiens (Human) - ZNF322 gene Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity). Taurus_UMD|evm.model.AC_000173.1.112 A0JNC2 R3HD2_BOVIN 79.951 0.979167 0.776542 R3HDM2 - R3H domain-containing protein 2 - Bos taurus (Bovine) - R3HDM2 gene Taurus_UMD|evm.model.AC_000173.1.117 P10103 HMGB1_BOVIN 98.605 0.990741 1.00465 HMGB1 - High mobility group protein B1 - Bos taurus (Bovine) - HMGB1 gene Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins (By similarity). Taurus_UMD|evm.model.AC_000173.1.118 P15907 SIAT1_HUMAN 82.927 0.952941 0.20936 ST6GAL1 - Beta-galactoside alpha-2,6-sialyltransferase 1 - Homo sapiens (Human) - ST6GAL1 gene Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. Taurus_UMD|evm.model.AC_000173.1.120 Q9NZ43 USE1_HUMAN 90.184 0.925714 0.675676 USE1 - Vesicle transport protein USE1 - Homo sapiens (Human) - USE1 gene SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Taurus_UMD|evm.model.AC_000173.1.121 Q8JZM7 CDC73_MOUSE 90.019 0.995825 0.902072 Cdc73 - Parafibromin - Mus musculus (Mouse) - Cdc73 gene Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors (By similarity). Taurus_UMD|evm.model.AC_000173.1.122 Q32L67 GLRX2_BOVIN 100.000 0.987342 1.00637 GLRX2 - Glutaredoxin-2, mitochondrial precursor - Bos taurus (Bovine) - GLRX2 gene Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release (By similarity). Taurus_UMD|evm.model.AC_000173.1.123 P10155 RO60_HUMAN 95.725 0.996289 1.00186 RO60 - 60 kDa SS-A/Ro ribonucleoprotein - Homo sapiens (Human) - RO60 gene RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation (PubMed:18056422). Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853). Taurus_UMD|evm.model.AC_000173.1.124 Q06AT3 UCHL5_PIG 99.696 0.993939 1.00304 UCHL5 - Ubiquitin carboxyl-terminal hydrolase isozyme L5 - Sus scrofa (Pig) - UCHL5 gene Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). Taurus_UMD|evm.model.AC_000173.1.125 Q0P5H5 RGS2_BOVIN 99.490 0.989848 0.933649 RGS2 - Regulator of G-protein signaling 2 - Bos taurus (Bovine) - RGS2 gene Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity). Taurus_UMD|evm.model.AC_000173.1.126 O14921 RGS13_HUMAN 89.781 0.490975 1.74214 RGS13 - Regulator of G-protein signaling 13 - Homo sapiens (Human) - RGS13 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity). Taurus_UMD|evm.model.AC_000173.1.127 Q6RG78 RGS1_HORSE 92.857 0.928571 1.07143 RGS1 - Regulator of G-protein signaling 1 - Equus caballus (Horse) - RGS1 gene Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). Taurus_UMD|evm.model.AC_000173.1.128 Q2M5E4 RGS21_HUMAN 94.118 0.980392 0.335526 RGS21 - Regulator of G-protein signaling 21 - Homo sapiens (Human) - RGS21 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Taurus_UMD|evm.model.AC_000173.1.129 Q2M5E4 RGS21_HUMAN 90.625 0.636364 0.651316 RGS21 - Regulator of G-protein signaling 21 - Homo sapiens (Human) - RGS21 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Taurus_UMD|evm.model.AC_000173.1.130 Q9NS28 RGS18_HUMAN 75.319 0.990385 0.885106 RGS18 - Regulator of G-protein signaling 18 - Homo sapiens (Human) - RGS18 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha. Taurus_UMD|evm.model.AC_000173.1.131 P12749 RL26_RAT 97.500 0.709091 0.37931 Rpl26 - 60S ribosomal protein L26 - Rattus norvegicus (Rat) - Rpl26 gene cytoplasm, cytosolic large ribosomal subunit, cytosolic ribosome, nucleolus, nucleoplasm, ribonucleoprotein complex, terminal bouton, mRNA 5'-UTR binding, RNA binding, structural constituent of ribosome Taurus_UMD|evm.model.AC_000173.1.132 P61255 RL26_MOUSE 93.617 0.978947 0.655172 Rpl26 - 60S ribosomal protein L26 - Mus musculus (Mouse) - Rpl26 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000173.1.133 Q9NQP4 PFD4_HUMAN 68.852 0.936508 0.470149 PFDN4 - Prefoldin subunit 4 - Homo sapiens (Human) - PFDN4 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Taurus_UMD|evm.model.AC_000173.1.134 Q76B58 BRNP3_HUMAN 97.911 0.997392 1.00131 BRINP3 - BMP/retinoic acid-inducible neural-specific protein 3 precursor - Homo sapiens (Human) - BRINP3 gene Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development. Taurus_UMD|evm.model.AC_000173.1.139 O60291 MGRN1_HUMAN 93.088 0.981818 0.398551 MGRN1 - E3 ubiquitin-protein ligase MGRN1 - Homo sapiens (Human) - MGRN1 gene E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). Taurus_UMD|evm.model.AC_000173.1.141 Q9Y597 KCTD3_HUMAN 96.691 0.997552 1.00245 KCTD3 - BTB/POZ domain-containing protein KCTD3 - Homo sapiens (Human) - KCTD3 gene Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. Taurus_UMD|evm.model.AC_000173.1.142 Q2QI47 USH2A_MOUSE 90.000 0.0154997 0.360293 Ush2A - Usherin precursor - Mus musculus (Mouse) - Ush2A gene Involved in hearing and vision as member of the USH2 complex (PubMed:20502675). In the inner ear, required for the maintenance of hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells (PubMed:20502675, PubMed:24334608). In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport (PubMed:20502675). Taurus_UMD|evm.model.AC_000173.1.143 O75445 USH2A_HUMAN 80.743 0.621053 0.091311 USH2A - Usherin precursor - Homo sapiens (Human) - USH2A gene Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Taurus_UMD|evm.model.AC_000173.1.144 O75445 USH2A_HUMAN 77.540 0.913158 0.146098 USH2A - Usherin precursor - Homo sapiens (Human) - USH2A gene Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Taurus_UMD|evm.model.AC_000173.1.145 O75445 USH2A_HUMAN 76.959 0.824427 0.0503652 USH2A - Usherin precursor - Homo sapiens (Human) - USH2A gene Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Taurus_UMD|evm.model.AC_000173.1.146 P62510 ERR3_RAT 100.000 0.995413 0.951965 Esrrg - Estrogen-related receptor gamma - Rattus norvegicus (Rat) - Esrrg gene Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle (By similarity). Taurus_UMD|evm.model.AC_000173.1.147 Q9NW75 GPTC2_HUMAN 93.750 0.9125 1.06061 GPATCH2 - G patch domain-containing protein 2 - Homo sapiens (Human) - GPATCH2 gene Enhances the ATPase activity of DHX15 in vitro. Taurus_UMD|evm.model.AC_000173.1.148 Q96L03 SPT17_HUMAN 82.320 0.99449 1.00554 SPATA17 - Spermatogenesis-associated protein 17 - Homo sapiens (Human) - SPATA17 gene calmodulin binding Taurus_UMD|evm.model.AC_000173.1.149 Q5NVM9 HSP7C_PONAB 90.000 0.649635 0.212074 HSPA8 - Heat shock cognate 71 kDa protein - Pongo abelii (Sumatran orangutan) - HSPA8 gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. Interacts with VGF-derived peptide TLQP-21. Taurus_UMD|evm.model.AC_000173.1.150 Q3T062 RRP15_BOVIN 100.000 0.925325 1.07692 RRP15 - RRP15-like protein - Bos taurus (Bovine) - RRP15 gene preribosome, large subunit precursor, maturation of 5.8S rRNA, maturation of LSU-rRNA Taurus_UMD|evm.model.AC_000173.1.151 P21214 TGFB2_BOVIN 100.000 0.995181 1.00242 TGFB2 - Transforming growth factor beta-2 proprotein precursor - Bos taurus (Bovine) - TGFB2 gene Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Taurus_UMD|evm.model.AC_000173.1.152 Q9NXK6 PAQR5_HUMAN 77.885 0.762963 0.409091 PAQR5 - Membrane progestin receptor gamma - Homo sapiens (Human) - PAQR5 gene Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167). Taurus_UMD|evm.model.AC_000173.1.153 Q5JUK9 PAGE3_HUMAN 50.526 0.783333 1.06195 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Taurus_UMD|evm.model.AC_000173.1.154 Q5VWZ2 LYPL1_HUMAN 89.610 0.987124 0.983122 LYPLAL1 - Lysophospholipase-like protein 1 - Homo sapiens (Human) - LYPLAL1 gene Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site. Taurus_UMD|evm.model.AC_000173.1.156 Q6XR72 ZNT10_HUMAN 83.951 0.995893 1.00412 SLC30A10 - Zinc transporter 10 - Homo sapiens (Human) - SLC30A10 gene Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death (PubMed:22341972, PubMed:22341971, PubMed:25319704, PubMed:27226609, PubMed:27307044). Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells (PubMed:22706290, PubMed:22427991, PubMed:26728129). Taurus_UMD|evm.model.AC_000173.1.157 Q6XR72 ZNT10_HUMAN 44.898 0.797753 0.36701 SLC30A10 - Zinc transporter 10 - Homo sapiens (Human) - SLC30A10 gene Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death (PubMed:22341972, PubMed:22341971, PubMed:25319704, PubMed:27226609, PubMed:27307044). Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells (PubMed:22706290, PubMed:22427991, PubMed:26728129). Taurus_UMD|evm.model.AC_000173.1.158 P07814 SYEP_HUMAN 92.328 0.998677 1 EPRS1 - Bifunctional glutamate/proline--tRNA ligase - Homo sapiens (Human) - EPRS1 gene Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (PubMed:1756734, PubMed:24100331, PubMed:23263184). The phosphorylation of EPRS1, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex and recruits it to the GAIT complex that binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin), suppressing their translation. Interferon-gamma can therefore redirect, in specific cells, the EPRS1 function from protein synthesis to translation inhibition (PubMed:15479637, PubMed:23071094). Also functions as an effector of the mTORC1 signaling pathway by promoting, through SLC27A1, the uptake of long-chain fatty acid by adipocytes. Thereby, it also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). Taurus_UMD|evm.model.AC_000173.1.159 Q3ZCK3 BPNT1_BOVIN 95.356 0.96988 1.07792 BPNT1 - 3'(2'),5'-bisphosphate nucleotidase 1 - Bos taurus (Bovine) - BPNT1 gene Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6 (By similarity). Taurus_UMD|evm.model.AC_000173.1.160 Q9NSE4 SYIM_HUMAN 89.450 0.997709 0.862648 IARS2 - Isoleucine--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - IARS2 gene mitochondrial matrix, mitochondrion, isoleucine-tRNA ligase activity, isoleucyl-tRNA aminoacylation, mitochondrial translation, tRNA aminoacylation for protein translation Taurus_UMD|evm.model.AC_000173.1.161 Q9H2M9 RBGPR_HUMAN 92.534 0.998564 1 RAB3GAP2 - Rab3 GTPase-activating protein non-catalytic subunit - Homo sapiens (Human) - RAB3GAP2 gene Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. Taurus_UMD|evm.model.AC_000173.1.162 Q9P0L2 MARK1_HUMAN 97.172 0.992337 0.984906 MARK1 - Serine/threonine-protein kinase MARK1 - Homo sapiens (Human) - MARK1 gene Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Taurus_UMD|evm.model.AC_000173.1.163 Q9H7X2 CA115_HUMAN 75.000 0.985612 0.978873 C1orf115 - Uncharacterized protein C1orf115 - Homo sapiens (Human) - C1orf115 gene 9+0 non-motile cilium Taurus_UMD|evm.model.AC_000173.1.164 Q1LZH1 MARC2_BOVIN 99.689 0.987692 0.967262 MTARC2 - Mitochondrial amidoxime reducing component 2 precursor - Bos taurus (Bovine) - MTARC2 gene Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction. Taurus_UMD|evm.model.AC_000173.1.165 Q5VT66 MARC1_HUMAN 86.350 0.991124 1.00297 MTARC1 - Mitochondrial amidoxime-reducing component 1 - Homo sapiens (Human) - MTARC1 gene Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:19053771, PubMed:21029045, PubMed:30397129). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:19053771). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045, PubMed:19053771). Taurus_UMD|evm.model.AC_000173.1.166 A7MB54 HLX_BOVIN 100.000 0.995893 1.00206 HLX - H2.0-like homeobox protein - Bos taurus (Bovine) - HLX gene Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity). Taurus_UMD|evm.model.AC_000173.1.168 Q58DW0 RL4_BOVIN 68.000 0.951923 0.246445 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Taurus_UMD|evm.model.AC_000173.1.169 Q0IID7 DUS10_BOVIN 100.000 0.995859 1.00207 DUSP10 - Dual specificity protein phosphatase 10 - Bos taurus (Bovine) - DUSP10 gene Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Taurus_UMD|evm.model.AC_000173.1.171 Q9UN81 LORF1_HUMAN 49.327 0.71521 0.914201 L1RE1 - LINE-1 retrotransposable element ORF1 protein - Homo sapiens (Human) - L1RE1 gene Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. Taurus_UMD|evm.model.AC_000173.1.172 Q6UWX4 HIPL2_HUMAN 88.474 0.583181 1.51105 HHIPL2 - HHIP-like protein 2 precursor - Homo sapiens (Human) - HHIPL2 gene Taurus_UMD|evm.model.AC_000173.1.173 Q0VC16 TGO1_BOVIN 96.389 0.998913 0.965879 MIA3 - Transport and Golgi organization protein 1 homolog precursor - Bos taurus (Bovine) - MIA3 gene Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum. Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES. Taurus_UMD|evm.model.AC_000173.1.174 Q5RAV3 AIDA_PONAB 99.673 0.993485 1.00327 AIDA - Axin interactor, dorsalization-associated protein - Pongo abelii (Sumatran orangutan) - AIDA gene Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). Taurus_UMD|evm.model.AC_000173.1.175 Q5RDD7 BROX_PONAB 96.594 0.864979 1.15328 BROX - BRO1 domain-containing protein BROX precursor - Pongo abelii (Sumatran orangutan) - BROX gene Taurus_UMD|evm.model.AC_000173.1.176 A6PVY3 F177B_HUMAN 67.073 0.48503 1.05696 FAM177B - Protein FAM177B - Homo sapiens (Human) - FAM177B gene Taurus_UMD|evm.model.AC_000173.1.177 Q13825 AUHM_HUMAN 71.951 0.955017 0.852507 AUH - Methylglutaconyl-CoA hydratase, mitochondrial precursor - Homo sapiens (Human) - AUH gene Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA (PubMed:11738050, PubMed:12434311, PubMed:12655555). Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Has very low enoyl-CoA hydratase activity (PubMed:7892223). Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs (PubMed:7892223). Taurus_UMD|evm.model.AC_000173.1.178 Q96F81 DISP1_HUMAN 91.134 0.998695 1.00591 DISP1 - Protein dispatched homolog 1 - Homo sapiens (Human) - DISP1 gene Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404). Taurus_UMD|evm.model.AC_000173.1.179 O60602 TLR5_HUMAN 78.438 0.997672 1.00117 TLR5 - Toll-like receptor 5 precursor - Homo sapiens (Human) - TLR5 gene Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:20855887, PubMed:11489966). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity). Taurus_UMD|evm.model.AC_000173.1.180 Q5VX71 SUSD4_HUMAN 71.930 0.460705 0.753061 SUSD4 - Sushi domain-containing protein 4 precursor - Homo sapiens (Human) - SUSD4 gene Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. Taurus_UMD|evm.model.AC_000173.1.181 Q8N715 CC185_HUMAN 60.063 0.996825 1.01124 CCDC185 - Coiled-coil domain-containing protein 185 - Homo sapiens (Human) - CCDC185 gene Taurus_UMD|evm.model.AC_000173.1.182 Q78EJ9 CAN8_RAT 79.310 0.930986 1.00996 Capn8 - Calpain-8 - Rattus norvegicus (Rat) - Capn8 gene Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity). Taurus_UMD|evm.model.AC_000173.1.183 Q27971 CAN2_BOVIN 94.714 0.99701 0.955714 CAPN2 - Calpain-2 catalytic subunit precursor - Bos taurus (Bovine) - CAPN2 gene Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. Taurus_UMD|evm.model.AC_000173.1.184 Q13625 ASPP2_HUMAN 91.652 0.998225 0.999113 TP53BP2 - Apoptosis-stimulating of p53 protein 2 - Homo sapiens (Human) - TP53BP2 gene Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. Taurus_UMD|evm.model.AC_000173.1.185 Q2NL16 FBX28_BOVIN 100.000 0.99446 0.980978 FBXO28 - F-box only protein 28 - Bos taurus (Bovine) - FBXO28 gene Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Taurus_UMD|evm.model.AC_000173.1.186 Q3ZBY7 DEGS1_BOVIN 90.000 0.329545 0.272446 DEGS1 - Sphingolipid delta(4)-desaturase DES1 - Bos taurus (Bovine) - DEGS1 gene Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity). Catalyzes the equilibrium isomerization of retinols (By similarity). Taurus_UMD|evm.model.AC_000173.1.187 Q3ZBY7 DEGS1_BOVIN 100.000 0.993056 0.891641 DEGS1 - Sphingolipid delta(4)-desaturase DES1 - Bos taurus (Bovine) - DEGS1 gene Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity). Catalyzes the equilibrium isomerization of retinols (By similarity). Taurus_UMD|evm.model.AC_000173.1.188 O15381 NVL_HUMAN 88.276 0.997701 1.01636 NVL - Nuclear valosin-containing protein-like - Homo sapiens (Human) - NVL gene Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111). Taurus_UMD|evm.model.AC_000173.1.189 Q3T126 CNIH4_BOVIN 100.000 0.985714 1.00719 CNIH4 - Protein cornichon homolog 4 - Bos taurus (Bovine) - CNIH4 gene Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery. Taurus_UMD|evm.model.AC_000173.1.190 Q9H7D7 WDR26_HUMAN 99.396 0.827284 1.20877 WDR26 - WD repeat-containing protein 26 - Homo sapiens (Human) - WDR26 gene G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity). Taurus_UMD|evm.model.AC_000173.1.191 Q58DT3 ZDHC4_BOVIN 65.441 0.983193 0.346939 ZDHHC4 - Palmitoyltransferase ZDHHC4 - Bos taurus (Bovine) - ZDHHC4 gene Palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates including the D(2) dopamine receptor DRD2. Taurus_UMD|evm.model.AC_000173.1.192 Q6ZWS4 CNIH3_MOUSE 99.375 0.987578 1.00625 Cnih3 - Protein cornichon homolog 3 - Mus musculus (Mouse) - Cnih3 gene Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization (By similarity). Taurus_UMD|evm.model.AC_000173.1.193 P18111 CDX1_MOUSE 53.333 0.513043 0.429104 Cdx1 - Homeobox protein CDX-1 - Mus musculus (Mouse) - Cdx1 gene Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA. Taurus_UMD|evm.model.AC_000173.1.194 Q9C0G6 DYH6_HUMAN 35.284 0.901714 1.05219 DNAH6 - Dynein axonemal heavy chain 6 - Homo sapiens (Human) - DNAH6 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Taurus_UMD|evm.model.AC_000173.1.195 Q14739 LBR_HUMAN 86.473 0.996785 1.01138 LBR - Delta(14)-sterol reductase LBR - Homo sapiens (Human) - LBR gene Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:9630650, PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). Taurus_UMD|evm.model.AC_000173.1.196 Q8N8S7 ENAH_HUMAN 88.344 0.389744 1.3198 ENAH - Protein enabled homolog - Homo sapiens (Human) - ENAH gene Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). Taurus_UMD|evm.model.AC_000173.1.197 P21262 SRP09_CANLF 98.837 0.977011 1.01163 SRP9 - Signal recognition particle 9 kDa protein - Canis lupus familiaris (Dog) - SRP9 gene Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. Taurus_UMD|evm.model.AC_000173.1.198 P79381 HYEP_PIG 87.445 0.995575 0.995595 EPHX1 - Epoxide hydrolase 1 - Sus scrofa (Pig) - EPHX1 gene Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (By similarity). Taurus_UMD|evm.model.AC_000173.1.199 A0A452G813 CSCL1_CAPHI 96.389 0.73309 1.36239 TMEM63A - CSC1-like protein 1 - Capra hircus (Goat) - TMEM63A gene Acts as an osmosensitive calcium-permeable cation channel (By similarity). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion (By similarity). Taurus_UMD|evm.model.AC_000173.1.200 O00292 LFTY2_HUMAN 82.834 0.994565 1.00546 LEFTY2 - Left-right determination factor 2 precursor - Homo sapiens (Human) - LEFTY2 gene Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. Taurus_UMD|evm.model.AC_000173.1.201 Q17QJ7 P5CR2_BOVIN 100.000 0.993769 1.00313 PYCR2 - Pyrroline-5-carboxylate reductase 2 - Bos taurus (Bovine) - PYCR2 gene Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity). Taurus_UMD|evm.model.AC_000173.1.202 O00292 LFTY2_HUMAN 81.744 0.994565 1.00546 LEFTY2 - Left-right determination factor 2 precursor - Homo sapiens (Human) - LEFTY2 gene Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. Taurus_UMD|evm.model.AC_000173.1.203 Q64368 DAZL_MOUSE 71.277 0.853211 0.365772 Dazl - Deleted in azoospermia-like - Mus musculus (Mouse) - Dazl gene RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts. Taurus_UMD|evm.model.AC_000173.1.204 Q6IQ49 SDE2_HUMAN 77.802 0.995595 1.00665 SDE2 - Replication stress response regulator SDE2 precursor - Homo sapiens (Human) - SDE2 gene Involved in both DNA replication and cell cycle control (PubMed:27906959). Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner (PubMed:27906959). Binding of SDE2 to PCNA is necessary to counteract damage due to ultraviolet light induced replication stress. The complete degradation of SDE2 is necessary to allow S-phase progression (PubMed:27906959). Taurus_UMD|evm.model.AC_000173.1.205 P84246 H33_RABIT 100.000 0.985401 1.00735 H3-3A - Histone H3.3 - Oryctolagus cuniculus (Rabbit) - H3-3A gene Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000173.1.206 Q9H3P7 GCP60_HUMAN 96.970 0.996219 1.00189 ACBD3 - Golgi resident protein GCP60 - Homo sapiens (Human) - ACBD3 gene Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). Taurus_UMD|evm.model.AC_000173.1.207 Q9H2W2 MIXL1_HUMAN 74.576 0.987395 1.02586 MIXL1 - Homeobox protein MIXL1 - Homo sapiens (Human) - MIXL1 gene Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). Taurus_UMD|evm.model.AC_000173.1.208 Q5TKA1 LIN9_HUMAN 85.609 0.962733 0.891144 LIN9 - Protein lin-9 homolog - Homo sapiens (Human) - LIN9 gene Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. Taurus_UMD|evm.model.AC_000173.1.209 P18493 PARP1_BOVIN 99.213 0.998033 1.00098 PARP1 - Poly [ADP-ribose] polymerase 1 - Bos taurus (Bovine) - PARP1 gene Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mediates glutamate, aspartate, serine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1. Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP1 active site. Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1. PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation. Mediates the poly(ADP-ribosyl)ation of a number of proteins, including itself, APLF and CHFR. In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Acts as a regulator of transcription: positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and EEF1A1. Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Taurus_UMD|evm.model.AC_000173.1.210 P10854 H2B1M_MOUSE 95.522 0.970588 0.539683 H2bc14 - Histone H2B type 1-M - Mus musculus (Mouse) - H2bc14 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000173.1.212 Q69YW2 STUM_HUMAN 95.745 0.985507 0.978723 STUM - Protein stum homolog - Homo sapiens (Human) - STUM gene Taurus_UMD|evm.model.AC_000173.1.213 Q1RMG8 RPAC2_BOVIN 99.248 0.985075 1.00752 POLR1D - DNA-directed RNA polymerases I and III subunit RPAC2 - Bos taurus (Bovine) - POLR1D gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. Taurus_UMD|evm.model.AC_000173.1.214 P27987 IP3KB_HUMAN 83.864 0.995434 0.463002 ITPKB - Inositol-trisphosphate 3-kinase B - Homo sapiens (Human) - ITPKB gene cytoplasm, cytosol, nucleus, inositol hexakisphosphate kinase activity, inositol-1,4,5-trisphosphate 3-kinase activity, kinase activity, cellular response to calcium ion, inositol phosphate biosynthetic process, inositol phosphate metabolic process, inositol trisphosphate metabolic process Taurus_UMD|evm.model.AC_000173.1.215 P27987 IP3KB_HUMAN 69.665 0.995717 0.493658 ITPKB - Inositol-trisphosphate 3-kinase B - Homo sapiens (Human) - ITPKB gene cytoplasm, cytosol, nucleus, inositol hexakisphosphate kinase activity, inositol-1,4,5-trisphosphate 3-kinase activity, kinase activity, cellular response to calcium ion, inositol phosphate biosynthetic process, inositol phosphate metabolic process, inositol trisphosphate metabolic process Taurus_UMD|evm.model.AC_000173.1.216 Q9XT96 PSN2_BOVIN 100.000 0.955224 1.04454 PSEN2 - Presenilin-2 - Bos taurus (Bovine) - PSEN2 gene Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria. Taurus_UMD|evm.model.AC_000173.1.217 Q29RI0 COQ8A_BOVIN 100.000 0.996918 1.00154 COQ8A - Atypical kinase COQ8A, mitochondrial precursor - Bos taurus (Bovine) - COQ8A gene Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. Shows an unusual selectivity for binding ADP over ATP. Taurus_UMD|evm.model.AC_000173.1.218 Q5VT25 MRCKA_HUMAN 96.420 0.998826 0.983834 CDC42BPA - Serine/threonine-protein kinase MRCK alpha - Homo sapiens (Human) - CDC42BPA gene Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). Taurus_UMD|evm.model.AC_000173.1.219 Q2KIW6 PRS10_BOVIN 97.778 0.505682 0.452442 PSMC6 - 26S proteasome regulatory subunit 10B - Bos taurus (Bovine) - PSMC6 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Taurus_UMD|evm.model.AC_000173.1.220 Q8WYP5 ELYS_HUMAN 80.658 0.999122 1.00485 AHCTF1 - Protein ELYS - Homo sapiens (Human) - AHCTF1 gene Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. Taurus_UMD|evm.model.AC_000173.1.221 B7ZC32 KIF28_HUMAN 76.351 0.9751 1.03826 KIF28P - Kinesin-like protein KIF28P - Homo sapiens (Human) - KIF28P gene Microtubule-dependent motor protein required for mitochondrion morhology and transport of mitochondria in neuronal cells. Taurus_UMD|evm.model.AC_000173.1.222 Q3T067 SCPDL_BOVIN 99.767 0.995349 1.00233 SCCPDH - Saccharopine dehydrogenase-like oxidoreductase - Bos taurus (Bovine) - SCCPDH gene Taurus_UMD|evm.model.AC_000173.1.223 Q3SZB8 H3CL_BOVIN 100.000 0.985401 1.00735 Histone H3.3C-like - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000173.1.224 Q45FY6 HPRT_PIG 72.477 0.959391 0.90367 HPRT1 - Hypoxanthine-guanine phosphoribosyltransferase - Sus scrofa (Pig) - HPRT1 gene Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). Taurus_UMD|evm.model.AC_000173.1.225 Q6PJW8 CNST_HUMAN 82.852 0.799378 0.886897 CNST - Consortin - Homo sapiens (Human) - CNST gene Required for targeting of connexins to the plasma membrane. Taurus_UMD|evm.model.AC_000173.1.226 Q32LD4 TFB2M_BOVIN 100.000 0.994937 1.00254 TFB2M - Dimethyladenosine transferase 2, mitochondrial precursor - Bos taurus (Bovine) - TFB2M gene S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulates transcription independently of the methyltransferase activity. Taurus_UMD|evm.model.AC_000173.1.227 Q9H7B4 SMYD3_HUMAN 90.395 0.884422 0.464953 SMYD3 - Histone-lysine N-methyltransferase SMYD3 - Homo sapiens (Human) - SMYD3 gene Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates 'Lys-5' of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609). Taurus_UMD|evm.model.AC_000173.1.229 Q9H7B4 SMYD3_HUMAN 94.167 0.97541 0.285047 SMYD3 - Histone-lysine N-methyltransferase SMYD3 - Homo sapiens (Human) - SMYD3 gene Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates 'Lys-5' of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609). Taurus_UMD|evm.model.AC_000173.1.230 Q2KJY2 KI26B_HUMAN 94.769 0.961481 0.320209 KIF26B - Kinesin-like protein KIF26B - Homo sapiens (Human) - KIF26B gene Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). Taurus_UMD|evm.model.AC_000173.1.232 Q2KJY2 KI26B_HUMAN 98.519 0.797619 0.0796964 KIF26B - Kinesin-like protein KIF26B - Homo sapiens (Human) - KIF26B gene Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). Taurus_UMD|evm.model.AC_000173.1.233 Q5VUJ9 DRC8_HUMAN 89.916 0.715152 0.613383 EFCAB2 - Dynein regulatory complex protein 8 - Homo sapiens (Human) - EFCAB2 gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Taurus_UMD|evm.model.AC_000173.1.234 Q00839 HNRPU_HUMAN 98.573 0.981767 0.864242 HNRNPU - Heterogeneous nuclear ribonucleoprotein U - Homo sapiens (Human) - HNRNPU gene DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:8174554, PubMed:28622508). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:8174554, PubMed:9353307, PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component ARNTL/BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Contributes also to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:7509195, PubMed:1324173, PubMed:9204873, PubMed:9405365, PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:28622508). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). Taurus_UMD|evm.model.AC_000173.1.235 Q9D7J4 COX20_MOUSE 83.051 0.966942 1.03419 Cox20 - Cytochrome c oxidase assembly protein COX20, mitochondrial - Mus musculus (Mouse) - Cox20 gene Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme. Taurus_UMD|evm.model.AC_000173.1.237 Q9BSY9 DESI2_HUMAN 98.969 0.989744 1.00515 DESI2 - Deubiquitinase DESI2 - Homo sapiens (Human) - DESI2 gene Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization (PubMed:28483520). Taurus_UMD|evm.model.AC_000173.1.238 Q5SY80 CTSRE_HUMAN 72.566 0.131301 0.896951 CATSPERE - Cation channel sperm-associated protein subunit epsilon precursor - Homo sapiens (Human) - CATSPERE gene Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Taurus_UMD|evm.model.AC_000173.1.239 A7MBG0 PURA2_BOVIN 100.000 0.995624 1.00219 ADSS2 - Adenylosuccinate synthetase isozyme 2 - Bos taurus (Bovine) - ADSS2 gene Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Taurus_UMD|evm.model.AC_000173.1.240 Q32L72 CA100_BOVIN 100.000 0.985612 1.00725 Uncharacterized protein C1orf100 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000173.1.241 A0JN76 ZBT18_BOVIN 100.000 0.979323 1.01916 ZBTB18 - Zinc finger and BTB domain-containing protein 18 - Bos taurus (Bovine) - ZBTB18 gene Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May also play a role in the organization of chromosomes in the nucleus (By similarity). Taurus_UMD|evm.model.AC_000173.1.242 Q9WUA6 AKT3_MOUSE 100.000 0.993007 0.298539 Akt3 - RAC-gamma serine/threonine-protein kinase - Mus musculus (Mouse) - Akt3 gene AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. Taurus_UMD|evm.model.AC_000173.1.243 Q86SQ7 SDCG8_HUMAN 81.513 0.942971 1.0575 SDCCAG8 - Serologically defined colon cancer antigen 8 - Homo sapiens (Human) - SDCCAG8 gene Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Plays also an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062). Taurus_UMD|evm.model.AC_000173.1.244 Q5SW79 CE170_HUMAN 89.590 0.998719 0.98548 CEP170 - Centrosomal protein of 170 kDa - Homo sapiens (Human) - CEP170 gene Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). Taurus_UMD|evm.model.AC_000173.1.246 Q8N7P1 PLD5_HUMAN 100.000 0.342541 0.337687 PLD5 - Inactive phospholipase D5 - Homo sapiens (Human) - PLD5 gene Taurus_UMD|evm.model.AC_000173.1.247 Q8N7P1 PLD5_HUMAN 95.319 0.993644 0.880597 PLD5 - Inactive phospholipase D5 - Homo sapiens (Human) - PLD5 gene Taurus_UMD|evm.model.AC_000173.1.248 A8MW95 BECN2_HUMAN 59.535 0.988426 1.00232 BECN2 - Beclin-2 - Homo sapiens (Human) - BECN2 gene Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1. Taurus_UMD|evm.model.AC_000173.1.249 Q9BXW4 MLP3C_HUMAN 85.938 0.13147 6.57143 MAP1LC3C - Microtubule-associated proteins 1A/1B light chain 3C precursor - Homo sapiens (Human) - MAP1LC3C gene Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium (PubMed:23022382). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643). Taurus_UMD|evm.model.AC_000173.1.250 B1ANS9 WDR64_HUMAN 85.134 0.998153 1.00185 WDR64 - WD repeat-containing protein 64 - Homo sapiens (Human) - WDR64 gene Taurus_UMD|evm.model.AC_000173.1.251 P26374 RAE2_HUMAN 81.126 0.996933 0.993902 CHML - Rab proteins geranylgeranyltransferase component A 2 - Homo sapiens (Human) - CHML gene Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. Taurus_UMD|evm.model.AC_000173.1.252 Q9MZS9 KMO_PIG 80.467 0.995536 0.951168 KMO - Kynurenine 3-monooxygenase - Sus scrofa (Pig) - KMO gene Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Taurus_UMD|evm.model.AC_000173.1.253 P10173 FUMH_PIG 95.117 0.996086 0.998047 FH - Fumarate hydratase, mitochondrial precursor - Sus scrofa (Pig) - FH gene Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:21498518). Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). Taurus_UMD|evm.model.AC_000173.1.254 O46470 RGS7_BOVIN 100.000 0.995745 1.00213 RGS7 - Regulator of G-protein signaling 7 - Bos taurus (Bovine) - RGS7 gene Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. Taurus_UMD|evm.model.AC_000173.1.255 P47961 RS4_CRIGR 76.147 0.930435 0.437262 RPS4 - 40S ribosomal protein S4 - Cricetulus griseus (Chinese hamster) - RPS4 gene Taurus_UMD|evm.model.AC_000173.1.256 P47992 XCL1_HUMAN 69.298 0.982301 0.991228 XCL1 - Lymphotactin precursor - Homo sapiens (Human) - XCL1 gene Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. Taurus_UMD|evm.model.AC_000173.1.257 P47992 XCL1_HUMAN 66.337 0.969388 0.859649 XCL1 - Lymphotactin precursor - Homo sapiens (Human) - XCL1 gene Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. Taurus_UMD|evm.model.AC_000173.1.259 P19427 DERM_BOVIN 79.104 0.9875 0.79602 DPT - Dermatopontin precursor - Bos taurus (Bovine) - DPT gene Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation. Taurus_UMD|evm.model.AC_000173.1.261 P05028 AT1B1_SHEEP 99.340 0.993421 1.0033 ATP1B1 - Sodium/potassium-transporting ATPase subunit beta-1 - Ovis aries (Sheep) - ATP1B1 gene This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Taurus_UMD|evm.model.AC_000173.1.262 Q5E9Y9 NDK7_BOVIN 83.024 0.99375 0.848806 NME7 - Nucleoside diphosphate kinase 7 - Bos taurus (Bovine) - NME7 gene Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Taurus_UMD|evm.model.AC_000173.1.263 Q9H2G9 GO45_HUMAN 89.526 0.995025 1.005 BLZF1 - Golgin-45 - Homo sapiens (Human) - BLZF1 gene Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. Taurus_UMD|evm.model.AC_000173.1.264 P63164 RSMN_RAT 59.302 0.75 0.433333 Snrpn - Small nuclear ribonucleoprotein-associated protein N - Rattus norvegicus (Rat) - Snrpn gene May be involved in tissue-specific alternative RNA processing events. Taurus_UMD|evm.model.AC_000173.1.265 Q5TID7 CC181_HUMAN 83.333 0.973231 1.0275 CCDC181 - Coiled-coil domain-containing protein 181 - Homo sapiens (Human) - CCDC181 gene Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Taurus_UMD|evm.model.AC_000173.1.266 O60779 S19A2_HUMAN 92.757 0.995976 1 SLC19A2 - Thiamine transporter 1 - Homo sapiens (Human) - SLC19A2 gene High-affinity transporter for the intake of thiamine. Taurus_UMD|evm.model.AC_000173.1.267 Q28107 FA5_BOVIN 95.749 0.999059 0.961556 F5 - Coagulation factor V precursor - Bos taurus (Bovine) - F5 gene Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. Taurus_UMD|evm.model.AC_000173.1.268 P42201 LYAM3_BOVIN 98.716 0.928358 1.03715 SELP - P-selectin precursor - Bos taurus (Bovine) - SELP gene Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes (PubMed:7683458). Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG (By similarity). Taurus_UMD|evm.model.AC_000173.1.269 P98107 LYAM2_BOVIN 100.000 0.537349 1.71134 SELE - E-selectin precursor - Bos taurus (Bovine) - SELE gene Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. Taurus_UMD|evm.model.AC_000173.1.270 Q2KIJ2 MET18_BOVIN 100.000 0.994652 1.00268 METTL18 - Histidine protein methyltransferase 1 homolog - Bos taurus (Bovine) - METTL18 gene Probable histidine methyltransferase. Taurus_UMD|evm.model.AC_000173.1.271 Q9NSG2 CA112_HUMAN 83.816 0.916851 1.05744 C1orf112 - Uncharacterized protein C1orf112 - Homo sapiens (Human) - C1orf112 gene Taurus_UMD|evm.model.AC_000173.1.272 Q8IZE3 PACE1_HUMAN 83.176 0.997279 0.990566 SCYL3 - Protein-associating with the carboxyl-terminal domain of ezrin - Homo sapiens (Human) - SCYL3 gene May play a role in regulating cell adhesion/migration complexes in migrating cells. Taurus_UMD|evm.model.AC_000173.1.273 Q92845 KIFA3_HUMAN 95.038 0.968234 0.993687 KIFAP3 - Kinesin-associated protein 3 - Homo sapiens (Human) - KIFAP3 gene Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity). Taurus_UMD|evm.model.AC_000173.1.274 Q5VVY1 NTM1B_HUMAN 94.346 0.992958 1.00353 METTL11B - Alpha N-terminal protein methyltransferase 1B - Homo sapiens (Human) - METTL11B gene Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation. Taurus_UMD|evm.model.AC_000173.1.275 A5PKK7 GORAB_BOVIN 99.730 0.931818 1.07027 GORAB - RAB6-interacting golgin - Bos taurus (Bovine) - GORAB gene Taurus_UMD|evm.model.AC_000173.1.276 P63014 PRRX1_RAT 99.184 0.99187 1.00408 Prrx1 - Paired mesoderm homeobox protein 1 - Rattus norvegicus (Rat) - Prrx1 gene Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). Taurus_UMD|evm.model.AC_000173.1.277 Q5TGP6 MROH9_HUMAN 58.954 0.551425 1.40838 MROH9 - Maestro heat-like repeat-containing protein family member 9 - Homo sapiens (Human) - MROH9 gene Taurus_UMD|evm.model.AC_000173.1.278 Q8HYJ9 FMO3_BOVIN 100.000 0.996248 1.00188 FMO3 - Dimethylaniline monooxygenase [N-oxide-forming] 3 - Bos taurus (Bovine) - FMO3 gene Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation. Taurus_UMD|evm.model.AC_000173.1.279 O60774 FMO6_HUMAN 85.658 0.996024 0.93321 FMO6P - Putative dimethylaniline monooxygenase [N-oxide-forming] 6 - Homo sapiens (Human) - FMO6P gene It is probable that this protein is only produced in very small quantity or not at all as the gene coding for it seems to be unable to produce full-length transcripts. Taurus_UMD|evm.model.AC_000173.1.280 Q8HZ70 FMO2_PANTR 85.741 0.996248 0.996262 FMO2 - Dimethylaniline monooxygenase [N-oxide-forming] 2 - Pan troglodytes (Chimpanzee) - FMO2 gene This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Taurus_UMD|evm.model.AC_000173.1.282 P16549 FMO1_PIG 90.789 0.943162 1.05827 FMO1 - Dimethylaniline monooxygenase [N-oxide-forming] 1 - Sus scrofa (Pig) - FMO1 gene This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Taurus_UMD|evm.model.AC_000173.1.283 P31512 FMO4_HUMAN 86.000 0.99637 0.987455 FMO4 - Dimethylaniline monooxygenase [N-oxide-forming] 4 - Homo sapiens (Human) - FMO4 gene This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Taurus_UMD|evm.model.AC_000173.1.284 Q9Y520 PRC2C_HUMAN 88.306 0.999299 0.985152 PRRC2C - Protein PRRC2C - Homo sapiens (Human) - PRRC2C gene Required for efficient formation of stress granules. Taurus_UMD|evm.model.AC_000173.1.285 Q9XTA3 MYOC_BOVIN 99.388 0.995927 1.00204 MYOC - Myocilin precursor - Bos taurus (Bovine) - MYOC gene Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork. Taurus_UMD|evm.model.AC_000173.1.286 Q32L97 VAMP4_BOVIN 100.000 0.985915 1.00709 VAMP4 - Vesicle-associated membrane protein 4 - Bos taurus (Bovine) - VAMP4 gene Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (By similarity). Taurus_UMD|evm.model.AC_000173.1.287 A5PK19 EFNMT_BOVIN 100.000 0.997143 1.00143 EEF1AKNMT - eEF1A lysine and N-terminal methyltransferase - Bos taurus (Bovine) - EEF1AKNMT gene Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation. Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2'. Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55'. Taurus_UMD|evm.model.AC_000173.1.289 O95561 CA105_HUMAN 70.652 0.989189 1.01093 C1orf105 - Uncharacterized protein C1orf105 - Homo sapiens (Human) - C1orf105 gene Taurus_UMD|evm.model.AC_000173.1.290 Q9UBS9 SUCO_HUMAN 87.510 0.998396 0.994418 SUCO - SUN domain-containing ossification factor precursor - Homo sapiens (Human) - SUCO gene Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity). Taurus_UMD|evm.model.AC_000173.1.291 Q861W5 TNFL6_FELCA 88.214 0.992806 0.992857 FASLG - Tumor necrosis factor ligand superfamily member 6 - Felis catus (Cat) - FASLG gene Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. Taurus_UMD|evm.model.AC_000173.1.292 Q3T160 NPM_BOVIN 95.578 0.993127 0.989796 NPM1 - Nucleophosmin - Bos taurus (Bovine) - NPM1 gene Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. Taurus_UMD|evm.model.AC_000173.1.293 P50502 F10A1_HUMAN 80.952 0.954023 0.235772 ST13 - Hsc70-interacting protein - Homo sapiens (Human) - ST13 gene One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). Taurus_UMD|evm.model.AC_000173.1.294 Q8IZP2 ST134_HUMAN 93.919 0.567568 1.07917 ST13P4 - Putative protein FAM10A4 - Homo sapiens (Human) - ST13P4 gene extracellular exosome, heat shock protein binding, chaperone cofactor-dependent protein refolding, protein-containing complex assembly Taurus_UMD|evm.model.AC_000173.1.295 Q9UNG2 TNF18_HUMAN 76.316 0.982609 0.577889 TNFSF18 - Tumor necrosis factor ligand superfamily member 18 - Homo sapiens (Human) - TNFSF18 gene Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). Taurus_UMD|evm.model.AC_000173.1.297 P23510 TNFL4_HUMAN 69.231 0.983607 1 TNFSF4 - Tumor necrosis factor ligand superfamily member 4 - Homo sapiens (Human) - TNFSF4 gene Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Taurus_UMD|evm.model.AC_000173.1.298 Q58DT1 RL7_BOVIN 94.964 0.971831 0.572581 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Taurus_UMD|evm.model.AC_000173.1.299 Q8IX15 HOMEZ_HUMAN 86.905 0.497006 0.303636 HOMEZ - Homeobox and leucine zipper protein Homez - Homo sapiens (Human) - HOMEZ gene May function as a transcriptional regulator. Taurus_UMD|evm.model.AC_000173.1.300 Q5VUY2 ADCL4_HUMAN 66.904 0.992908 0.692875 AADACL4 - Arylacetamide deacetylase-like 4 - Homo sapiens (Human) - AADACL4 gene hydrolase activity Taurus_UMD|evm.model.AC_000173.1.301 O77769 DHRS3_BOVIN 98.485 0.637255 0.337748 DHRS3 - Short-chain dehydrogenase/reductase 3 - Bos taurus (Bovine) - DHRS3 gene Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH. Taurus_UMD|evm.model.AC_000173.1.302 O75911 DHRS3_HUMAN 71.818 0.811321 0.350993 DHRS3 - Short-chain dehydrogenase/reductase 3 - Homo sapiens (Human) - DHRS3 gene Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH. Taurus_UMD|evm.model.AC_000173.1.303 O75911 DHRS3_HUMAN 100.000 0.843931 0.572848 DHRS3 - Short-chain dehydrogenase/reductase 3 - Homo sapiens (Human) - DHRS3 gene Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH. Taurus_UMD|evm.model.AC_000173.1.304 Q5THJ4 VP13D_HUMAN 97.902 0.991672 0.328396 VPS13D - Vacuolar protein sorting-associated protein 13D - Homo sapiens (Human) - VPS13D gene Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. Taurus_UMD|evm.model.AC_000173.1.305 Q5THJ4 VP13D_HUMAN 93.774 0.992248 0.0587967 VPS13D - Vacuolar protein sorting-associated protein 13D - Homo sapiens (Human) - VPS13D gene Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. Taurus_UMD|evm.model.AC_000173.1.306 Q5THJ4 VP13D_HUMAN 93.090 0.997751 0.608022 VPS13D - Vacuolar protein sorting-associated protein 13D - Homo sapiens (Human) - VPS13D gene Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. Taurus_UMD|evm.model.AC_000173.1.307 P20333 TNR1B_HUMAN 69.528 0.995652 0.997831 TNFRSF1B - Tumor necrosis factor receptor superfamily member 1B precursor - Homo sapiens (Human) - TNFRSF1B gene Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Taurus_UMD|evm.model.AC_000173.1.308 P28908 TNR8_HUMAN 63.373 0.987973 0.978151 TNFRSF8 - Tumor necrosis factor receptor superfamily member 8 precursor - Homo sapiens (Human) - TNFRSF8 gene Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898). Taurus_UMD|evm.model.AC_000173.1.309 Q5JXC2 MIIP_HUMAN 71.350 0.708 1.28866 MIIP - Migration and invasion-inhibitory protein - Homo sapiens (Human) - MIIP gene Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. Taurus_UMD|evm.model.AC_000173.1.310 O95140 MFN2_HUMAN 92.206 0.997249 0.96037 MFN2 - Mitofusin-2 - Homo sapiens (Human) - MFN2 gene Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:26214738, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity). Taurus_UMD|evm.model.AC_000173.1.311 Q63321 PLOD1_RAT 92.663 0.884181 0.972527 Plod1 - Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor - Rattus norvegicus (Rat) - Plod1 gene Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:7578263). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity). Taurus_UMD|evm.model.AC_000173.1.312 Q2KHV9 K2013_BOVIN 99.369 0.99685 1.00158 Uncharacterized protein KIAA2013 homolog precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000173.1.313 P13204 ANFB_BOVIN 100.000 0.984615 1.00775 NPPB - Natriuretic peptides B precursor - Bos taurus (Bovine) - NPPB gene Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3 (By similarity). Taurus_UMD|evm.model.AC_000173.1.314 P07501 ANF_BOVIN 100.000 0.986928 1.00658 NPPA - Natriuretic peptides A precursor - Bos taurus (Bovine) - NPPA gene Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (By similarity). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (By similarity). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (By similarity). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (By similarity). This includes upregulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (By similarity). Binds the clearance receptor NPR3 which removes the hormone from circulation (By similarity). Taurus_UMD|evm.model.AC_000173.1.315 P51797 CLCN6_HUMAN 95.977 0.997704 1.0023 CLCN6 - Chloride transport protein 6 - Homo sapiens (Human) - CLCN6 gene Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. Taurus_UMD|evm.model.AC_000173.1.316 Q5I598 MTHR_BOVIN 99.237 0.938307 1.06412 MTHFR - Methylenetetrahydrofolate reductase - Bos taurus (Bovine) - MTHFR gene Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Taurus_UMD|evm.model.AC_000173.1.317 Q5SNV9 CA167_HUMAN 65.517 0.0390144 0.995232 C1orf167 - Uncharacterized protein C1orf167 - Homo sapiens (Human) - C1orf167 gene Taurus_UMD|evm.model.AC_000173.1.318 Q6RW13 ATRAP_HUMAN 74.214 0.693694 1.39623 AGTRAP - Type-1 angiotensin II receptor-associated protein - Homo sapiens (Human) - AGTRAP gene Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. Taurus_UMD|evm.model.AC_000173.1.319 P0C8S2 DRAXI_BOVIN 100.000 0.994083 1.00297 DRAXIN - Draxin precursor - Bos taurus (Bovine) - DRAXIN gene Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. Taurus_UMD|evm.model.AC_000173.1.320 Q9UI95 MD2L2_HUMAN 99.526 0.990566 1.00474 MAD2L2 - Mitotic spindle assembly checkpoint protein MAD2B - Homo sapiens (Human) - MAD2L2 gene Adapter protein able to interact with different proteins and involved in different biological processes (PubMed:11459825, PubMed:11459826, PubMed:17719540, PubMed:17296730, PubMed:19443654, PubMed:29656893). Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis (PubMed:20164194). Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions (PubMed:20164194). Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1 (PubMed:17296730). Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle (PubMed:11459825, PubMed:17719540). Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation (PubMed:19443654). Taurus_UMD|evm.model.AC_000173.1.321 Q3SX24 FBX6_BOVIN 100.000 0.992481 1.00377 FBXO6 - F-box only protein 6 - Bos taurus (Bovine) - FBXO6 gene Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). Taurus_UMD|evm.model.AC_000173.1.322 Q8BK26 FBX44_MOUSE 97.403 0.809859 1.11373 Fbxo44 - F-box only protein 44 - Mus musculus (Mouse) - Fbxo44 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000173.1.323 Q17QK6 FBX2_BOVIN 100.000 0.993289 1.00337 FBXO2 - F-box only protein 2 - Bos taurus (Bovine) - FBXO2 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity). Taurus_UMD|evm.model.AC_000173.1.324 Q9P2K9 DISP3_HUMAN 91.176 0.975473 1.02514 DISP3 - Protein dispatched homolog 3 - Homo sapiens (Human) - DISP3 gene Plays a role in neuronal proliferation and differentiation (PubMed:25281927). Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation (PubMed:25281927). May contribute to cholesterol homeostasis in neuronal cells (By similarity). Taurus_UMD|evm.model.AC_000173.1.325 D2HKB0 UBIA1_AILME 94.225 0.984985 0.988131 UBIAD1 - UbiA prenyltransferase domain-containing protein 1 - Ailuropoda melanoleuca (Giant panda) - UBIAD1 gene Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress (By similarity). Taurus_UMD|evm.model.AC_000173.1.326 P42345 MTOR_HUMAN 99.608 0.999216 1.00118 MTOR - Serine/threonine-protein kinase mTOR - Homo sapiens (Human) - MTOR gene Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18925875, PubMed:18497260, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (By similarity). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12150925, PubMed:12087098, PubMed:18925875). This also includes mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3: in the presence of nutrients, mediates phosphorylation of TFEB and TFE3, promoting their cytosolic retention and inactivation (PubMed:22576015, PubMed:22343943, PubMed:22692423). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22576015, PubMed:22343943, PubMed:22692423). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429704, PubMed:23429703). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (By similarity). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). mTORC1 also negatively regulates autophagy through phosphorylation of ULK1 (By similarity). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (By similarity). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton (PubMed:15268862, PubMed:15467718). Plays a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1 (PubMed:15718470). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). Phosphorylates SQSTM1, promoting interaction between SQSTM1 and KEAP1 and subsequent inactivation of the BCR(KEAP1) complex (By similarity). Taurus_UMD|evm.model.AC_000173.1.327 Q01780 EXOSX_HUMAN 89.741 0.997748 1.00339 EXOSC10 - Exosome component 10 - Homo sapiens (Human) - EXOSC10 gene Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA. Taurus_UMD|evm.model.AC_000173.1.328 Q64674 SPEE_MOUSE 94.702 0.993399 1.00331 Srm - Spermidine synthase - Mus musculus (Mouse) - Srm gene Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine (By similarity). Taurus_UMD|evm.model.AC_000173.1.329 O00187 MASP2_HUMAN 83.772 0.992722 1.00146 MASP2 - Mannan-binding lectin serine protease 2 precursor - Homo sapiens (Human) - MASP2 gene Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. Taurus_UMD|evm.model.AC_000173.1.330 Q921F2 TADBP_MOUSE 98.068 0.995181 1.00242 Tardbp - TAR DNA-binding protein 43 - Mus musculus (Mouse) - Tardbp gene RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (By similarity). Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (By similarity). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). Taurus_UMD|evm.model.AC_000173.1.332 Q86V15 CASZ1_HUMAN 93.015 0.977661 0.865264 CASZ1 - Zinc finger protein castor homolog 1 - Homo sapiens (Human) - CASZ1 gene Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). Taurus_UMD|evm.model.AC_000173.1.333 O75381 PEX14_HUMAN 94.164 0.994667 0.994695 PEX14 - Peroxisomal membrane protein PEX14 - Homo sapiens (Human) - PEX14 gene Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin. Taurus_UMD|evm.model.AC_000173.1.334 O00273 DFFA_HUMAN 78.788 0.990909 0.996979 DFFA - DNA fragmentation factor subunit alpha - Homo sapiens (Human) - DFFA gene Inhibitor of the caspase-activated DNase (DFF40). Taurus_UMD|evm.model.AC_000173.1.335 O00230 CORT_HUMAN 67.416 0.727273 1.15238 CORT - Cortistatin precursor - Homo sapiens (Human) - CORT gene Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs. Taurus_UMD|evm.model.AC_000173.1.336 Q2TBR7 CENPS_BOVIN 100.000 0.978571 1.01449 CENPS - Centromere protein S - Bos taurus (Bovine) - CENPS gene DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own. Taurus_UMD|evm.model.AC_000173.1.337 P00349 6PGD_SHEEP 97.723 0.995868 1.00207 PGD - 6-phosphogluconate dehydrogenase, decarboxylating - Ovis aries (Sheep) - PGD gene Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Taurus_UMD|evm.model.AC_000173.1.339 P62264 RS14_MOUSE 93.939 0.833333 0.516556 Rps14 - 40S ribosomal protein S14 - Mus musculus (Mouse) - Rps14 gene cytosol, cytosolic small ribosomal subunit, mitochondrion, nucleolus, postsynaptic density, mRNA 5'-UTR binding, RNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome, translation regulator activity Taurus_UMD|evm.model.AC_000173.1.340 Q9ES00 UBE4B_MOUSE 97.901 0.663243 1.16198 Ube4b - Ubiquitin conjugation factor E4 B - Mus musculus (Mouse) - Ube4b gene Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (PubMed:11435423). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (By similarity). Taurus_UMD|evm.model.AC_000173.1.341 Q96R05 RET7_HUMAN 87.313 0.985185 1.00746 RBP7 - Retinoid-binding protein 7 - Homo sapiens (Human) - RBP7 gene Intracellular transport of retinol. Taurus_UMD|evm.model.AC_000173.1.342 Q0VD50 NMNA1_BOVIN 100.000 0.701754 1.41993 NMNAT1 - Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 - Bos taurus (Bovine) - NMNAT1 gene Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Protects against axonal degeneration following mechanical or toxic insults (By similarity). Taurus_UMD|evm.model.AC_000173.1.343 Q5E9N2 CNBP1_BOVIN 100.000 0.295238 2.59259 CTNNBIP1 - Beta-catenin-interacting protein 1 - Bos taurus (Bovine) - CTNNBIP1 gene Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Taurus_UMD|evm.model.AC_000173.1.344 O94985 CSTN1_HUMAN 91.483 0.946162 1.02243 CLSTN1 - Calsyntenin-1 precursor - Homo sapiens (Human) - CLSTN1 gene Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity). Taurus_UMD|evm.model.AC_000173.1.345 O00329 PK3CD_HUMAN 95.307 0.998086 1.00096 PIK3CD - Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform - Homo sapiens (Human) - PIK3CD gene Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:9235916). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Plays a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Plays important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity. Taurus_UMD|evm.model.AC_000173.1.346 Q32PF0 TM201_BOVIN 100.000 0.578475 1.70229 TMEM201 - Transmembrane protein 201 - Bos taurus (Bovine) - TMEM201 gene May define a distinct membrane domain in the vicinity of the mitotic spindle. Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina. Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow. May recruit Ran GTPase to the nuclear periphery. Taurus_UMD|evm.model.AC_000173.1.347 Q1LZB3 S2533_BOVIN 100.000 0.993789 1.00312 SLC25A33 - Solute carrier family 25 member 33 - Bos taurus (Bovine) - SLC25A33 gene Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production. Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation. Taurus_UMD|evm.model.AC_000173.1.349 Q5UAW9 GP157_HUMAN 83.636 0.978659 0.979104 GPR157 - G-protein coupled receptor 157 - Homo sapiens (Human) - GPR157 gene Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger. Taurus_UMD|evm.model.AC_000173.1.350 P58353 GTR5_BOVIN 100.000 0.991379 0.463074 SLC2A5 - Solute carrier family 2, facilitated glucose transporter member 5 - Bos taurus (Bovine) - SLC2A5 gene Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake. Taurus_UMD|evm.model.AC_000173.1.351 P18915 CAH6_BOVIN 99.373 0.99375 1.00313 CA6 - Carbonic anhydrase 6 precursor - Bos taurus (Bovine) - CA6 gene Reversible hydration of carbon dioxide. Its role in saliva is unknown. Taurus_UMD|evm.model.AC_000173.1.352 Q9XSJ4 ENOA_BOVIN 99.770 0.864271 1.15438 ENO1 - Alpha-enolase - Bos taurus (Bovine) - ENO1 gene Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:7499243). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity). Taurus_UMD|evm.model.AC_000173.1.353 Q9P2R6 RERE_HUMAN 94.408 0.980595 0.987229 RERE - Arginine-glutamic acid dipeptide repeats protein - Homo sapiens (Human) - RERE gene Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. Taurus_UMD|evm.model.AC_000173.1.355 Q8BIV7 S45A1_MOUSE 89.257 0.940075 1.06658 Slc45a1 - Proton-associated sugar transporter A - Mus musculus (Mouse) - Slc45a1 gene Proton-associated glucose transporter in the brain. Taurus_UMD|evm.model.AC_000173.1.356 Q5JX71 F209A_HUMAN 46.512 0.78972 1.25146 FAM209A - Protein FAM209A precursor - Homo sapiens (Human) - FAM209A gene extracellular exosome, nucleus Taurus_UMD|evm.model.AC_000173.1.357 Q9UJM3 ERRFI_HUMAN 77.706 0.995662 0.997835 ERRFI1 - ERBB receptor feedback inhibitor 1 - Homo sapiens (Human) - ERRFI1 gene Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). Taurus_UMD|evm.model.AC_000173.1.358 Q5E946 PARK7_BOVIN 100.000 0.989474 1.00529 PARK7 - Parkinson disease protein 7 homolog precursor - Bos taurus (Bovine) - PARK7 gene Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease. It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway. Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. But this function is rebuted by other works. As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin. Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels. Displays a very low glyoxalase activity that may reflect its deglycase activity. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells. In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity. In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis. Taurus_UMD|evm.model.AC_000173.1.359 Q07011 TNR9_HUMAN 74.118 0.992157 1 TNFRSF9 - Tumor necrosis factor receptor superfamily member 9 precursor - Homo sapiens (Human) - TNFRSF9 gene Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. Taurus_UMD|evm.model.AC_000173.1.360 P56645 PER3_HUMAN 70.968 0.484127 0.104913 PER3 - Period circadian protein homolog 3 - Homo sapiens (Human) - PER3 gene Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. Taurus_UMD|evm.model.AC_000173.1.361 P56645 PER3_HUMAN 62.402 0.785714 0.396336 PER3 - Period circadian protein homolog 3 - Homo sapiens (Human) - PER3 gene Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. Taurus_UMD|evm.model.AC_000173.1.362 P56645 PER3_HUMAN 77.612 0.852564 0.129892 PER3 - Period circadian protein homolog 3 - Homo sapiens (Human) - PER3 gene Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. Taurus_UMD|evm.model.AC_000173.1.363 P56645 PER3_HUMAN 74.910 0.627685 0.348876 PER3 - Period circadian protein homolog 3 - Homo sapiens (Human) - PER3 gene Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. Taurus_UMD|evm.model.AC_000173.1.364 Q9Y6Y1 CMTA1_HUMAN 94.134 0.929825 0.919904 CAMTA1 - Calmodulin-binding transcription activator 1 - Homo sapiens (Human) - CAMTA1 gene Transcriptional activator. May act as a tumor suppressor. Taurus_UMD|evm.model.AC_000173.1.366 Q9Y6Y1 CMTA1_HUMAN 100.000 0.267123 0.0872684 CAMTA1 - Calmodulin-binding transcription activator 1 - Homo sapiens (Human) - CAMTA1 gene Transcriptional activator. May act as a tumor suppressor. Taurus_UMD|evm.model.AC_000173.1.369 Q2NL21 DJC11_BOVIN 100.000 0.996429 1.00179 DNAJC11 - DnaJ homolog subfamily C member 11 - Bos taurus (Bovine) - DNAJC11 gene Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex. Taurus_UMD|evm.model.AC_000173.1.370 Q0P5B4 THAP3_BOVIN 100.000 0.991667 1.00418 THAP3 - THAP domain-containing protein 3 - Bos taurus (Bovine) - THAP3 gene Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Taurus_UMD|evm.model.AC_000173.1.371 Q86YI8 PHF13_HUMAN 95.000 0.993355 1.00333 PHF13 - PHD finger protein 13 - Homo sapiens (Human) - PHF13 gene Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis. Taurus_UMD|evm.model.AC_000173.1.372 Q08DS0 KLH21_BOVIN 99.832 0.996656 1.00168 KLHL21 - Kelch-like protein 21 - Bos taurus (Bovine) - KLHL21 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity). Taurus_UMD|evm.model.AC_000173.1.373 P10074 TZAP_HUMAN 92.587 0.958159 1.04215 ZBTB48 - Telomere zinc finger-associated protein - Homo sapiens (Human) - ZBTB48 gene Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891). Taurus_UMD|evm.model.AC_000173.1.374 Q7RTX1 TS1R1_HUMAN 75.862 0.997625 1.00119 TAS1R1 - Taste receptor type 1 member 1 precursor - Homo sapiens (Human) - TAS1R1 gene Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. Taurus_UMD|evm.model.AC_000173.1.375 E1BPN0 NOL9_BOVIN 100.000 0.997122 1.00144 NOL9 - Polynucleotide 5'-hydroxyl-kinase NOL9 - Bos taurus (Bovine) - NOL9 gene Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA (By similarity). Taurus_UMD|evm.model.AC_000173.1.376 O94827 PKHG5_HUMAN 87.870 0.90868 1.0994 PLEKHG5 - Pleckstrin homology domain-containing family G member 5 - Homo sapiens (Human) - PLEKHG5 gene Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity). Involved in the control of neuronal cell differentiation (PubMed:11704860). Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (PubMed:23777631). Taurus_UMD|evm.model.AC_000173.1.377 Q93038 TNR25_HUMAN 74.559 0.878924 1.06954 TNFRSF25 - Tumor necrosis factor receptor superfamily member 25 precursor - Homo sapiens (Human) - TNFRSF25 gene Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. Taurus_UMD|evm.model.AC_000173.1.378 B1AK53 ESPN_HUMAN 90.541 0.776596 0.11007 ESPN - Espin - Homo sapiens (Human) - ESPN gene Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells (PubMed:29572253). Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia (By similarity). Involved in the elongation of actin in stereocilia (PubMed:29572253). In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation. Taurus_UMD|evm.model.AC_000173.1.379 B1AK53 ESPN_HUMAN 72.562 0.537336 1.52108 ESPN - Espin - Homo sapiens (Human) - ESPN gene Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells (PubMed:29572253). Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia (By similarity). Involved in the elongation of actin in stereocilia (PubMed:29572253). In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation. Taurus_UMD|evm.model.AC_000173.1.380 Q9Y543 HES2_HUMAN 88.889 0.807229 0.959538 HES2 - Transcription factor HES-2 - Homo sapiens (Human) - HES2 gene Transcriptional repressor of genes that require a bHLH protein for their transcription. Taurus_UMD|evm.model.AC_000173.1.381 Q4R708 NAA35_MACFA 97.630 0.990566 0.292414 NAA35 - N-alpha-acetyltransferase 35, NatC auxiliary subunit - Macaca fascicularis (Crab-eating macaque) - NAA35 gene Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells. Taurus_UMD|evm.model.AC_000173.1.382 Q5RBT3 NAA35_PONAB 97.034 0.943775 0.343448 NAA35 - N-alpha-acetyltransferase 35, NatC auxiliary subunit - Pongo abelii (Sumatran orangutan) - NAA35 gene Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells (By similarity). Taurus_UMD|evm.model.AC_000173.1.383 Q4R708 NAA35_MACFA 97.973 0.986577 0.205517 NAA35 - N-alpha-acetyltransferase 35, NatC auxiliary subunit - Macaca fascicularis (Crab-eating macaque) - NAA35 gene Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells. Taurus_UMD|evm.model.AC_000173.1.384 Q91V12 BACH_MOUSE 94.479 0.958702 0.889764 Acot7 - Cytosolic acyl coenzyme A thioester hydrolase - Mus musculus (Mouse) - Acot7 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:15288813). Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (Probable). May play an important physiological function in brain (PubMed:15288813). Taurus_UMD|evm.model.AC_000173.1.385 Q6NV75 GP153_HUMAN 86.971 0.996727 1.00328 GPR153 - Probable G-protein coupled receptor 153 - Homo sapiens (Human) - GPR153 gene Orphan receptor. Taurus_UMD|evm.model.AC_000173.1.386 Q5TGS1 HES3_HUMAN 76.404 0.867647 1.09677 HES3 - Transcription factor HES-3 - Homo sapiens (Human) - HES3 gene Transcriptional repressor of genes that require a bHLH protein for their transcription. Taurus_UMD|evm.model.AC_000173.1.387 O60725 ICMT_HUMAN 96.809 0.989418 0.665493 ICMT - Protein-S-isoprenylcysteine O-methyltransferase - Homo sapiens (Human) - ICMT gene Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. Taurus_UMD|evm.model.AC_000173.1.388 A0JNG4 RN207_BOVIN 92.190 0.927445 1.14029 RNF207 - RING finger protein 207 - Bos taurus (Bovine) - RNF207 gene Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner. Taurus_UMD|evm.model.AC_000173.1.389 P67985 RL22_PIG 100.000 0.984496 1.00781 RPL22 - 60S ribosomal protein L22 - Sus scrofa (Pig) - RPL22 gene cytoplasmic side of rough endoplasmic reticulum membrane, large ribosomal subunit, RNA binding, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000173.1.390 Q8TDI0 CHD5_HUMAN 95.614 0.986598 0.992835 CHD5 - Chromodomain-helicase-DNA-binding protein 5 - Homo sapiens (Human) - CHD5 gene Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. Taurus_UMD|evm.model.AC_000173.1.391 Q27955 KCAB2_BOVIN 100.000 0.994565 1.00272 KCNAB2 - Voltage-gated potassium channel subunit beta-2 - Bos taurus (Bovine) - KCNAB2 gene Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (By similarity). Promotes KCNA4 channel closure (By similarity). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity). Taurus_UMD|evm.model.AC_000173.1.393 O75161 NPHP4_HUMAN 78.142 0.998603 1.00421 NPHP4 - Nephrocystin-4 - Homo sapiens (Human) - NPHP4 gene Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462). Taurus_UMD|evm.model.AC_000173.1.397 Q0EEE2 PTHD3_MOUSE 64.587 0.996063 0.560706 Ptchd3 - Patched domain-containing protein 3 - Mus musculus (Mouse) - Ptchd3 gene May play a role in sperm development or sperm function. Taurus_UMD|evm.model.AC_000173.1.398 P13789 TNNT2_BOVIN 98.413 0.753036 0.866667 TNNT2 - Troponin T, cardiac muscle - Bos taurus (Bovine) - TNNT2 gene Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Taurus_UMD|evm.model.AC_000173.1.399 O00515 LAD1_HUMAN 51.823 0.995652 0.889749 LAD1 - Ladinin-1 - Homo sapiens (Human) - LAD1 gene Anchoring filament protein which is a component of the basement membrane zone. Taurus_UMD|evm.model.AC_000173.1.400 P19237 TNNI1_HUMAN 96.809 0.989418 1.0107 TNNI1 - Troponin I, slow skeletal muscle - Homo sapiens (Human) - TNNI1 gene Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Taurus_UMD|evm.model.AC_000173.1.401 Q3MHY1 CSRP1_BOVIN 100.000 0.989691 1.00518 CSRP1 - Cysteine and glycine-rich protein 1 - Bos taurus (Bovine) - CSRP1 gene Could play a role in neuronal development. Taurus_UMD|evm.model.AC_000173.1.403 Q8NEY1 NAV1_HUMAN 91.986 0.349815 0.431007 NAV1 - Neuron navigator 1 - Homo sapiens (Human) - NAV1 gene May be involved in neuronal migration. Taurus_UMD|evm.model.AC_000173.1.404 Q8NEY1 NAV1_HUMAN 92.302 0.987179 0.789558 NAV1 - Neuron navigator 1 - Homo sapiens (Human) - NAV1 gene May be involved in neuronal migration. Taurus_UMD|evm.model.AC_000173.1.405 Q96P70 IPO9_HUMAN 93.571 0.98249 0.987512 IPO9 - Importin-9 - Homo sapiens (Human) - IPO9 gene Functions in nuclear protein import as nuclear transport receptor (PubMed:11823430). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of RPS7, RPL18A, RPL6, histone H2A, histone H2B and histone (PubMed:11823430). Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains (PubMed:11823430). Mediates the nuclear import of actin (By similarity). Taurus_UMD|evm.model.AC_000173.1.406 Q96DD7 SHSA4_HUMAN 92.857 0.816993 0.77665 SHISA4 - Protein shisa-4 precursor - Homo sapiens (Human) - SHISA4 gene Taurus_UMD|evm.model.AC_000173.1.407 P29536 LMOD1_HUMAN 75.828 0.996546 0.965 LMOD1 - Leiomodin-1 - Homo sapiens (Human) - LMOD1 gene Mediates nucleation of actin filaments. Taurus_UMD|evm.model.AC_000173.1.408 Q99595 TI17A_HUMAN 95.906 0.988372 1.00585 TIMM17A - Mitochondrial import inner membrane translocase subunit Tim17-A - Homo sapiens (Human) - TIMM17A gene Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Taurus_UMD|evm.model.AC_000173.1.409 Q9UKB5 AJAP1_HUMAN 84.173 0.995204 1.0146 AJAP1 - Adherens junction-associated protein 1 - Homo sapiens (Human) - AJAP1 gene Plays a role in cell adhesion and cell migration. Taurus_UMD|evm.model.AC_000173.1.417 Q32PF7 CA174_BOVIN 100.000 0.991597 1.00422 UPF0688 protein C1orf174 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000173.1.418 Q58CZ0 DFFB_BOVIN 99.707 0.994152 1.00293 DFFB - DNA fragmentation factor subunit beta - Bos taurus (Bovine) - DFFB gene Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology (By similarity). Taurus_UMD|evm.model.AC_000173.1.419 O60308 CE104_HUMAN 83.135 0.972632 1.02703 CEP104 - Centrosomal protein of 104 kDa - Homo sapiens (Human) - CEP104 gene Required for ciliogenesis and for structural integrity at the ciliary tip. Taurus_UMD|evm.model.AC_000173.1.420 Q8N1G4 LRC47_HUMAN 83.505 0.949097 1.0446 LRRC47 - Leucine-rich repeat-containing protein 47 - Homo sapiens (Human) - LRRC47 gene RNA binding Taurus_UMD|evm.model.AC_000173.1.421 P0C8K7 SMIM1_MOUSE 70.513 0.0967337 10.2051 Smim1 - Small integral membrane protein 1 - Mus musculus (Mouse) - Smim1 gene Regulator of red blood cell formation. Taurus_UMD|evm.model.AC_000173.1.422 Q9JJP2 P73_MOUSE 89.314 0.975039 1.01585 Tp73 - Tumor protein p73 - Mus musculus (Mouse) - Tp73 gene Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Taurus_UMD|evm.model.AC_000173.1.423 Q9P2S5 WRP73_HUMAN 87.391 0.995643 0.997826 WRAP73 - WD repeat-containing protein WRAP73 - Homo sapiens (Human) - WRAP73 gene The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238). Taurus_UMD|evm.model.AC_000173.1.424 Q32LJ4 TPRGL_BOVIN 100.000 0.749153 1.07273 TPRG1L - Tumor protein p63-regulated gene 1-like protein - Bos taurus (Bovine) - TPRG1L gene Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release. Taurus_UMD|evm.model.AC_000173.1.425 Q80V70 MEGF6_MOUSE 77.143 0.9769 1.04644 Megf6 - Multiple epidermal growth factor-like domains protein 6 precursor - Mus musculus (Mouse) - Megf6 gene collagen-containing extracellular matrix Taurus_UMD|evm.model.AC_000173.1.426 Q5VV41 ARHGG_HUMAN 83.075 0.845694 1.17913 ARHGEF16 - Rho guanine nucleotide exchange factor 16 - Homo sapiens (Human) - ARHGEF16 gene Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. Taurus_UMD|evm.model.AC_000173.1.427 A2A935 PRD16_MOUSE 88.869 0.954353 0.927843 Prdm16 - Histone-lysine N-methyltransferase PRDM16 - Mus musculus (Mouse) - Prdm16 gene Binds DNA and functions as a transcriptional regulator (PubMed:18483224). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (PubMed:22939622). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (PubMed:22939622). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (PubMed:22939622). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (PubMed:17618855, PubMed:18483224). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (PubMed:18719582, PubMed:19641492). Functions as a repressor of TGF-beta signaling. Taurus_UMD|evm.model.AC_000173.1.429 A2A935 PRD16_MOUSE 78.462 0.712644 0.136471 Prdm16 - Histone-lysine N-methyltransferase PRDM16 - Mus musculus (Mouse) - Prdm16 gene Binds DNA and functions as a transcriptional regulator (PubMed:18483224). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (PubMed:22939622). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (PubMed:22939622). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (PubMed:22939622). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (PubMed:17618855, PubMed:18483224). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (PubMed:18719582, PubMed:19641492). Functions as a repressor of TGF-beta signaling. Taurus_UMD|evm.model.AC_000173.1.431 Q2TA43 ACTT2_BOVIN 100.000 0.994709 1.00265 ACTRT2 - Actin-related protein T2 - Bos taurus (Bovine) - ACTRT2 gene Taurus_UMD|evm.model.AC_000173.1.432 Q3SZN0 SEPT6_BOVIN 69.069 0.968085 0.660422 SEPTIN6 - Septin-6 - Bos taurus (Bovine) - SEPTIN6 gene Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Taurus_UMD|evm.model.AC_000173.1.433 A8MYJ7 TTC34_HUMAN 75.618 0.546422 1.82686 TTC34 - Tetratricopeptide repeat protein 34 - Homo sapiens (Human) - TTC34 gene Taurus_UMD|evm.model.AC_000173.1.434 Q495T6 MMEL1_HUMAN 81.694 0.997512 1.03209 MMEL1 - Membrane metallo-endopeptidase-like 1 - Homo sapiens (Human) - MMEL1 gene Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity). Taurus_UMD|evm.model.AC_000173.1.435 Q58CY6 PXL2B_BOVIN 99.502 0.990099 1.00498 PRXL2B - Prostamide/prostaglandin F synthase - Bos taurus (Bovine) - PRXL2B gene Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity). Taurus_UMD|evm.model.AC_000173.1.436 Q03062 HES5_RAT 86.471 0.987952 1 Hes5 - Transcription factor HES-5 - Rattus norvegicus (Rat) - Hes5 gene Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity). Taurus_UMD|evm.model.AC_000173.1.437 Q4R4U1 PANK4_MACFA 94.696 0.997416 1.00129 PANK4 - 4'-phosphopantetheine phosphatase - Macaca fascicularis (Crab-eating macaque) - PANK4 gene May play a role in the physiological regulation of coenzyme A (CoA) intracellular levels. The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'-phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. Taurus_UMD|evm.model.AC_000173.1.438 A2AP18 PLCH2_MOUSE 81.071 0.988522 0.928714 Plch2 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 - Mus musculus (Mouse) - Plch2 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain. Taurus_UMD|evm.model.AC_000173.1.439 O60683 PEX10_HUMAN 77.301 0.875339 1.1319 PEX10 - Peroxisome biogenesis factor 10 - Homo sapiens (Human) - PEX10 gene Somewhat implicated in the biogenesis of peroxisomes. Taurus_UMD|evm.model.AC_000173.1.440 A5PJ65 RER1_BOVIN 99.490 0.667808 1.4898 RER1 - Protein RER1 - Bos taurus (Bovine) - RER1 gene Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. Taurus_UMD|evm.model.AC_000173.1.441 Q5T089 MORN1_HUMAN 63.895 0.936364 0.885312 MORN1 - MORN repeat-containing protein 1 - Homo sapiens (Human) - MORN1 gene Taurus_UMD|evm.model.AC_000173.1.442 Q9TUG2 SKI_HORSE 95.014 0.997151 0.961644 SKI - Ski oncogene - Equus caballus (Horse) - SKI gene May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling (By similarity). Taurus_UMD|evm.model.AC_000173.1.443 A5PKK9 FAP20_BOVIN 100.000 0.989637 1.00521 FAAP20 - Fanconi anemia core complex-associated protein 20 - Bos taurus (Bovine) - FAAP20 gene Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1 (By similarity). Taurus_UMD|evm.model.AC_000173.1.444 P09217 KPCZ_RAT 93.434 0.996639 1.00507 Prkcz - Protein kinase C zeta type - Rattus norvegicus (Rat) - Prkcz gene Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (By similarity). Taurus_UMD|evm.model.AC_000173.1.445 O14764 GBRD_HUMAN 92.255 0.960089 0.997788 GABRD - Gamma-aminobutyric acid receptor subunit delta precursor - Homo sapiens (Human) - GABRD gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Taurus_UMD|evm.model.AC_000173.1.446 Q9C0B2 CFA74_HUMAN 70.938 0.987234 1.03851 CFAP74 - Cilia- and flagella-associated protein 74 - Homo sapiens (Human) - CFAP74 gene As part of the central apparatus of the cilium axoneme may play a role in cilium movement. Taurus_UMD|evm.model.AC_000173.1.447 Q8NDY8 TMM52_HUMAN 79.592 0.858824 0.813397 TMEM52 - Transmembrane protein 52 precursor - Homo sapiens (Human) - TMEM52 gene Taurus_UMD|evm.model.AC_000173.1.448 Q8TD86 CALL6_HUMAN 54.404 0.979167 1.06077 CALML6 - Calmodulin-like protein 6 - Homo sapiens (Human) - CALML6 gene calcium ion binding, enzyme regulator activity Taurus_UMD|evm.model.AC_000173.1.449 P54311 GBB1_RAT 100.000 0.994135 1.00294 Gnb1 - Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 - Rattus norvegicus (Rat) - Gnb1 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Taurus_UMD|evm.model.AC_000173.1.450 O95544 NADK_HUMAN 90.115 0.955947 1.01794 NADK - NAD kinase - Homo sapiens (Human) - NADK gene cytosol, NAD+ kinase activity, ATP metabolic process, NAD metabolic process, NADP biosynthetic process, phosphorylation Taurus_UMD|evm.model.AC_000173.1.451 P0CK96 S352B_HUMAN 83.416 0.992611 1.00247 SLC35E2B - Solute carrier family 35 member E2B - Homo sapiens (Human) - SLC35E2B gene Putative transporter. Taurus_UMD|evm.model.AC_000173.1.452 P21127 CD11B_HUMAN 94.975 0.957055 1.02516 CDK11B - Cyclin-dependent kinase 11B - Homo sapiens (Human) - CDK11B gene Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. Taurus_UMD|evm.model.AC_000173.1.453 Q2TBM7 MMP23_BOVIN 99.746 0.994924 1.00254 MMP23 - Matrix metalloproteinase-23 precursor - Bos taurus (Bovine) - MMP23 gene Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity). Taurus_UMD|evm.model.AC_000173.1.454 Q96AX9 MIB2_HUMAN 88.854 0.971992 0.951629 MIB2 - E3 ubiquitin-protein ligase MIB2 - Homo sapiens (Human) - MIB2 gene E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Taurus_UMD|evm.model.AC_000173.1.455 F2Z333 FND10_HUMAN 87.283 0.655172 1.15487 FNDC10 - Fibronectin type III domain-containing protein 10 precursor - Homo sapiens (Human) - FNDC10 gene Taurus_UMD|evm.model.AC_000173.1.456 Q17QI2 SSU72_BOVIN 100.000 0.97076 0.881443 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Bos taurus (Bovine) - SSU72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK (By similarity). Taurus_UMD|evm.model.AC_000173.1.457 Q5SV17 TM240_HUMAN 98.639 0.986486 0.855491 TMEM240 - Transmembrane protein 240 - Homo sapiens (Human) - TMEM240 gene synaptic membrane Taurus_UMD|evm.model.AC_000173.1.458 A7YWC4 ATAD3_BOVIN 100.000 0.996593 1.00171 ATAD3 - ATPase family AAA domain-containing protein 3 - Bos taurus (Bovine) - ATAD3 gene Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. Involved in mitochondrial-mediated antiviral innate immunity. Taurus_UMD|evm.model.AC_000173.1.459 A6QLN9 VWA1_BOVIN 100.000 0.995169 1.00242 VWA1 - von Willebrand factor A domain-containing protein 1 precursor - Bos taurus (Bovine) - VWA1 gene Promotes matrix assembly. Taurus_UMD|evm.model.AC_000173.1.460 Q0VD38 TM88B_BOVIN 100.000 0.988024 1.00602 TMEM88B - Transmembrane protein 88B - Bos taurus (Bovine) - TMEM88B gene plasma membrane, PDZ domain binding Taurus_UMD|evm.model.AC_000173.1.461 A6QPE7 ANR65_BOVIN 100.000 0.994949 1.00253 ANKRD65 - Ankyrin repeat domain-containing protein 65 - Bos taurus (Bovine) - ANKRD65 gene Taurus_UMD|evm.model.AC_000173.1.462 Q2TBR2 RM20_BOVIN 100.000 0.986667 1.00671 MRPL20 - 39S ribosomal protein L20, mitochondrial precursor - Bos taurus (Bovine) - MRPL20 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, structural constituent of ribosome, ribosomal large subunit assembly Taurus_UMD|evm.model.AC_000173.1.463 Q96S94 CCNL2_HUMAN 92.638 0.93666 1.00192 CCNL2 - Cyclin-L2 - Homo sapiens (Human) - CCNL2 gene Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Taurus_UMD|evm.model.AC_000173.1.464 Q9NWT8 AKIP_HUMAN 74.874 0.99 1.00503 AURKAIP1 - Aurora kinase A-interacting protein - Homo sapiens (Human) - AURKAIP1 gene May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation. Taurus_UMD|evm.model.AC_000173.1.465 Q148M6 MXRA8_BOVIN 100.000 0.99569 1.00216 MXRA8 - Matrix remodeling-associated protein 8 precursor - Bos taurus (Bovine) - MXRA8 gene Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro. Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38. Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes. Stimulates formation of primary cilia in chondrocytes. Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway. Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis. Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells. Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK. May play a role in the maturation and maintenance of the blood-brain barrier. Taurus_UMD|evm.model.AC_000173.1.466 Q9WVB9 DVL1_RAT 96.329 0.993043 0.827338 Dvl1 - Segment polarity protein dishevelled homolog DVL-1 - Rattus norvegicus (Rat) - Dvl1 gene Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Taurus_UMD|evm.model.AC_000173.1.467 Q2TA03 UB2J2_BOVIN 100.000 0.992308 1.00386 UBE2J2 - Ubiquitin-conjugating enzyme E2 J2 - Bos taurus (Bovine) - UBE2J2 gene Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Taurus_UMD|evm.model.AC_000173.1.468 Q5T7M4 ADIPL_HUMAN 68.562 0.986667 0.993377 C1QTNF12 - Adipolin precursor - Homo sapiens (Human) - C1QTNF12 gene Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. Taurus_UMD|evm.model.AC_000173.1.469 Q96L58 B3GT6_HUMAN 89.274 0.951515 1.00304 B3GALT6 - Beta-1,3-galactosyltransferase 6 - Homo sapiens (Human) - B3GALT6 gene Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues. Taurus_UMD|evm.model.AC_000173.1.470 Q3ZBZ1 CAB45_BOVIN 94.465 0.957447 0.794366 SDF4 - 45 kDa calcium-binding protein precursor - Bos taurus (Bovine) - SDF4 gene May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. Taurus_UMD|evm.model.AC_000173.1.471 P43489 TNR4_HUMAN 62.724 0.992832 1.00722 TNFRSF4 - Tumor necrosis factor receptor superfamily member 4 precursor - Homo sapiens (Human) - TNFRSF4 gene Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. Taurus_UMD|evm.model.AC_000173.1.472 Q9Y5U5 TNR18_HUMAN 64.979 0.987013 0.958506 TNFRSF18 - Tumor necrosis factor receptor superfamily member 18 precursor - Homo sapiens (Human) - TNFRSF18 gene Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. Taurus_UMD|evm.model.AC_000173.1.473 A4Q9F3 TTL10_MOUSE 73.666 0.759259 1.07386 Ttll10 - Protein polyglycylase TTLL10 - Mus musculus (Mouse) - Ttll10 gene Polyglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Polyglycylates alpha-tubulin and beta-tubulin, but is not able to initiate glycylation and only has activity toward monoglycylated tubulin. Has the ability to polyglycylate non-tubulin proteins such as NAP1; in this case it can initiate glycylation and does not require preliminary monoglycylation by another glycylase. Taurus_UMD|evm.model.AC_000173.1.474 Q49HH9 TS1R3_CANLF 76.029 0.880342 0.553846 TAS1R3 - Taste receptor type 1 member 3 precursor - Canis lupus familiaris (Dog) - TAS1R3 gene Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity). Taurus_UMD|evm.model.AC_000173.1.475 Q49HH9 TS1R3_CANLF 80.163 0.658887 0.659172 TAS1R3 - Taste receptor type 1 member 3 precursor - Canis lupus familiaris (Dog) - TAS1R3 gene Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity). Taurus_UMD|evm.model.AC_000173.1.476 Q0VCQ0 CPTP_BOVIN 100.000 0.990698 1.00467 CPTP - Ceramide-1-phosphate transfer protein - Bos taurus (Bovine) - CPTP gene Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles. Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis. Taurus_UMD|evm.model.AC_000173.1.477 Q2YDM2 INT11_BOVIN 97.162 0.996575 0.974958 INTS11 - Integrator complex subunit 11 - Bos taurus (Bovine) - INTS11 gene Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Taurus_UMD|evm.model.AC_000173.1.478 Q8N0Z8 PUSL1_HUMAN 84.912 0.934211 1.0033 PUSL1 - tRNA pseudouridine synthase-like 1 - Homo sapiens (Human) - PUSL1 gene intracellular membrane-bounded organelle, mitochondrion, pseudouridine synthase activity, tRNA pseudouridine synthesis Taurus_UMD|evm.model.AC_000173.1.479 P51172 SCNND_HUMAN 62.295 0.904977 0.826683 SCNN1D - Amiloride-sensitive sodium channel subunit delta - Homo sapiens (Human) - SCNN1D gene Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Taurus_UMD|evm.model.AC_000173.1.480 Q96P50 ACAP3_HUMAN 91.859 0.982014 1 ACAP3 - Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 - Homo sapiens (Human) - ACAP3 gene GTPase-activating protein for the ADP ribosylation factor family. Taurus_UMD|evm.model.AC_000173.1.481 Q96HA4 CA159_HUMAN 70.423 0.700508 0.518421 C1orf159 - Uncharacterized protein C1orf159 precursor - Homo sapiens (Human) - C1orf159 gene Taurus_UMD|evm.model.AC_000173.1.482 E7ERA6 RN223_HUMAN 76.587 0.992 1.00402 RNF223 - RING finger protein 223 - Homo sapiens (Human) - RNF223 gene Taurus_UMD|evm.model.AC_000173.1.483 O00468 AGRIN_HUMAN 84.788 0.775221 1.26064 AGRN - Agrin precursor - Homo sapiens (Human) - AGRN gene heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain. Taurus_UMD|evm.model.AC_000173.1.484 O02741 ISG15_BOVIN 100.000 0.987097 1.00649 ISG15 - Ubiquitin-like protein ISG15 - Bos taurus (Bovine) - ISG15 gene Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Exhibits antiviral activity towards both DNA and RNA viruses. The secreted form of ISG15 can: induce natural killer cell proliferation, augment lymphokine-activated-killer (LAK) activity, induce dendritic cell maturation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity (By similarity). The secreted form acts through the integrin ITGAL/ITGB2 receptor to initiate activation of SRC family tyrosine kinases including LYN, HCK and FGR which leads to secretion of IFNG and IL10; the interaction is mediated by ITGAL (By similarity). In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy (PubMed:9546718). Taurus_UMD|evm.model.AC_000173.1.485 Q9HCC6 HES4_HUMAN 74.667 0.991031 1.00905 HES4 - Transcription factor HES-4 - Homo sapiens (Human) - HES4 gene Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity). Taurus_UMD|evm.model.AC_000173.1.486 A5D7L8 PERM1_BOVIN 100.000 0.997783 1.00111 PERM1 - PGC-1 and ERR-induced regulator in muscle protein 1 - Bos taurus (Bovine) - PERM1 gene Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4 (By similarity). Taurus_UMD|evm.model.AC_000173.1.487 Q494U1 PKHN1_HUMAN 70.244 0.996689 0.988543 PLEKHN1 - Pleckstrin homology domain-containing family N member 1 - Homo sapiens (Human) - PLEKHN1 gene Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1 (PubMed:29180010). Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (By similarity). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS) (PubMed:18191643). Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon cancer cells (PubMed:29531808) (By similarity). Taurus_UMD|evm.model.AC_000173.1.488 Q8K430 KLH17_RAT 97.823 0.996894 1.00625 Klhl17 - Kelch-like protein 17 - Rattus norvegicus (Rat) - Klhl17 gene Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function. Taurus_UMD|evm.model.AC_000173.1.489 Q3SYU1 NOC2L_BOVIN 100.000 0.997323 1.00134 NOC2L - Nucleolar complex protein 2 homolog - Bos taurus (Bovine) - NOC2L gene Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis (By similarity). Taurus_UMD|evm.model.AC_000173.1.490 Q96NU1 SAM11_HUMAN 82.507 0.786808 1.2467 SAMD11 - Sterile alpha motif domain-containing protein 11 - Homo sapiens (Human) - SAMD11 gene May play a role in photoreceptor development. Taurus_UMD|evm.model.AC_000173.1.491 Q13105 ZBT17_HUMAN 91.781 0.925444 1.0523 ZBTB17 - Zinc finger and BTB domain-containing protein 17 - Homo sapiens (Human) - ZBTB17 gene Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946). Taurus_UMD|evm.model.AC_000173.1.492 Q96T58 MINT_HUMAN 87.425 0.999453 0.996998 SPEN - Msx2-interacting protein - Homo sapiens (Human) - SPEN gene May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. Taurus_UMD|evm.model.AC_000173.1.493 Q5R8Z6 MCFD2_PONAB 91.096 0.986301 1 MCFD2 - Multiple coagulation factor deficiency protein 2 homolog precursor - Pongo abelii (Sumatran orangutan) - MCFD2 gene The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Taurus_UMD|evm.model.AC_000173.1.495 Q1JQB5 FBLI1_BOVIN 100.000 0.994723 1.00265 FBLIM1 - Filamin-binding LIM protein 1 - Bos taurus (Bovine) - FBLIM1 gene Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). Taurus_UMD|evm.model.AC_000173.1.496 A0PJX8 TMM82_HUMAN 81.493 0.965217 1.00583 TMEM82 - Transmembrane protein 82 - Homo sapiens (Human) - TMEM82 gene Taurus_UMD|evm.model.AC_000173.1.497 Q3SZK0 S2534_BOVIN 100.000 0.993443 1.00329 SLC25A34 - Solute carrier family 25 member 34 - Bos taurus (Bovine) - SLC25A34 gene Taurus_UMD|evm.model.AC_000173.1.500 Q8IWE5 PKHM2_HUMAN 89.812 0.994089 0.996075 PLEKHM2 - Pleckstrin homology domain-containing family M member 2 - Homo sapiens (Human) - PLEKHM2 gene Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:28325809, PubMed:22172677, PubMed:25898167, PubMed:24088571). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). Taurus_UMD|evm.model.AC_000173.1.501 Q5TDH0 DDI2_HUMAN 96.212 0.386497 2.5614 DDI2 - Protein DDI1 homolog 2 - Homo sapiens (Human) - DDI2 gene Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27676298, PubMed:27528193). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612). Taurus_UMD|evm.model.AC_000173.1.502 Q9BSE5 SPEB_HUMAN 85.000 0.991713 1.02841 AGMAT - Agmatinase, mitochondrial precursor - Homo sapiens (Human) - AGMAT gene mitochondrion, agmatinase activity, agmatine biosynthetic process, putrescine biosynthetic process from arginine, using agmatinase Taurus_UMD|evm.model.AC_000173.1.503 Q9Y2G8 DJC16_HUMAN 93.350 0.997446 1.00128 DNAJC16 - DnaJ homolog subfamily C member 16 precursor - Homo sapiens (Human) - DNAJC16 gene Taurus_UMD|evm.model.AC_000173.1.504 Q8C3Q9 CASP9_MOUSE 76.821 0.995585 0.997797 Casp9 - Caspase-9 precursor - Mus musculus (Mouse) - Casp9 gene Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) (By similarity). Taurus_UMD|evm.model.AC_000173.1.505 Q7M3E1 CTRC_BOVIN 100.000 0.507722 1.93284 CTRC - Chymotrypsin-C precursor - Bos taurus (Bovine) - CTRC gene Has chymotrypsin-type protease activity and hypocalcemic activity. Taurus_UMD|evm.model.AC_000173.1.506 A5D7A0 EFHD2_BOVIN 100.000 0.99177 1.00413 EFHD2 - EF-hand domain-containing protein D2 - Bos taurus (Bovine) - EFHD2 gene May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Taurus_UMD|evm.model.AC_000173.1.507 B1AJZ9 FHAD1_HUMAN 70.926 0.958877 1.08499 FHAD1 - Forkhead-associated domain-containing protein 1 - Homo sapiens (Human) - FHAD1 gene Taurus_UMD|evm.model.AC_000173.1.509 Q9NW97 TMM51_HUMAN 88.933 0.991968 0.98419 TMEM51 - Transmembrane protein 51 - Homo sapiens (Human) - TMEM51 gene Taurus_UMD|evm.model.AC_000173.1.510 Q674X7 KAZRN_HUMAN 97.159 0.988748 0.917419 KAZN - Kazrin - Homo sapiens (Human) - KAZN gene Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. Taurus_UMD|evm.model.AC_000173.1.512 Q674X7 KAZRN_HUMAN 82.609 0.497207 0.230968 KAZN - Kazrin - Homo sapiens (Human) - KAZN gene Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. Taurus_UMD|evm.model.AC_000173.1.513 Q9ULL1 PKHG1_HUMAN 61.824 0.777778 0.266426 PLEKHG1 - Pleckstrin homology domain-containing family G member 1 - Homo sapiens (Human) - PLEKHG1 gene nucleoplasm Taurus_UMD|evm.model.AC_000173.1.514 Q13029 PRDM2_HUMAN 84.944 0.987104 0.993015 PRDM2 - PR domain zinc finger protein 2 - Homo sapiens (Human) - PRDM2 gene S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. Taurus_UMD|evm.model.AC_000173.1.515 Q9UGL1 KDM5B_HUMAN 91.938 0.946727 1.00907 KDM5B - Lysine-specific demethylase 5B - Homo sapiens (Human) - KDM5B gene Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). Taurus_UMD|evm.model.AC_000173.1.516 Q86YL7 PDPN_HUMAN 46.857 0.988235 1.04938 PDPN - Podoplanin precursor - Homo sapiens (Human) - PDPN gene Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation (PubMed:14522983, PubMed:15231832, PubMed:17616532, PubMed:18215137, PubMed:17222411). Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN (PubMed:18541721). Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness (PubMed:17046996, PubMed:21376833). Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (PubMed:20962267). In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation (By similarity). Through binding with LGALS8 may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix (PubMed:19268462). In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion (PubMed:15515019). Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1 (PubMed:25486435). Required for normal lung cell proliferation and alveolus formation at birth (By similarity). Does not function as a water channel or as a regulator of aquaporin-type water channels (PubMed:9651190). Does not have any effect on folic acid or amino acid transport (By similarity). Taurus_UMD|evm.model.AC_000173.1.517 A6H684 MGT4E_MOUSE 58.466 0.785714 1.08428 Mgat4e - Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E - Mus musculus (Mouse) - Mgat4e gene Glycosyltransferase-like protein that may participate in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Taurus_UMD|evm.model.AC_000173.1.519 P47224 MSS4_HUMAN 86.992 0.983871 1.00813 RABIF - Guanine nucleotide exchange factor MSS4 - Homo sapiens (Human) - RABIF gene Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1, RAB3A and RAB10, but is less active on these proteins than on the SEC4 protein (PubMed:31540829). Might play a general role in vesicular transport. Taurus_UMD|evm.model.AC_000173.1.520 E1B932 KLH12_BOVIN 97.887 0.996429 0.985915 KLHL12 - Kelch-like protein 12 - Bos taurus (Bovine) - KLHL12 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export. As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins. Taurus_UMD|evm.model.AC_000173.1.521 Q91VH1 PAQR1_MOUSE 97.067 0.994681 1.00267 Adipor1 - Adiponectin receptor protein 1 - Mus musculus (Mouse) - Adipor1 gene Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:17327425, PubMed:17268472, PubMed:24742672). Required for normal glucose and fat homeostasis and for maintaining a normal body weight (PubMed:17327425, PubMed:24742672). ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis (PubMed:12802337, PubMed:17327425, PubMed:17268472, PubMed:24742672). Has high affinity for globular adiponectin and low affinity for full-length adiponectin (PubMed:12802337). Taurus_UMD|evm.model.AC_000173.1.522 Q3MHW9 NB5R1_BOVIN 100.000 0.821429 1.19344 CYB5R1 - NADH-cytochrome b5 reductase 1 - Bos taurus (Bovine) - CYB5R1 gene NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Taurus_UMD|evm.model.AC_000173.1.523 A6H684 MGT4E_MOUSE 38.760 0.709486 1.15262 Mgat4e - Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E - Mus musculus (Mouse) - Mgat4e gene Glycosyltransferase-like protein that may participate in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Taurus_UMD|evm.model.AC_000173.1.524 Q5VT99 LRC38_HUMAN 94.565 0.386076 1.61224 LRRC38 - Leucine-rich repeat-containing protein 38 precursor - Homo sapiens (Human) - LRRC38 gene Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. Taurus_UMD|evm.model.AC_000173.1.525 O60810 PRAM4_HUMAN 50.000 0.988739 0.92887 PRAMEF4 - PRAME family member 4 - Homo sapiens (Human) - PRAMEF4 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.526 Q5VXH4 PRAM6_HUMAN 64.000 0.148649 1.39916 PRAMEF6 - PRAME family member 6 - Homo sapiens (Human) - PRAMEF6 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.527 Q5VWM4 PRAM8_HUMAN 53.070 0.982646 0.972574 PRAMEF8 - PRAME family member 8 - Homo sapiens (Human) - PRAMEF8 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.528 O95522 PRA12_HUMAN 53.178 0.991471 0.971014 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.529 Q5VWM4 PRAM8_HUMAN 52.747 0.989059 0.964135 PRAMEF8 - PRAME family member 8 - Homo sapiens (Human) - PRAMEF8 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.530 P78395 PRAME_HUMAN 52.490 0.972803 0.939096 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Taurus_UMD|evm.model.AC_000173.1.531 Q5VWM5 PRAM9_HUMAN 49.029 0.981912 0.809623 PRAMEF9 - PRAME family member 9/15 - Homo sapiens (Human) - PRAMEF9 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.532 Q5TYX0 PRAM5_HUMAN 48.878 0.994286 0.735294 PRAMEF5 - PRAME family member 5 - Homo sapiens (Human) - PRAMEF5 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.533 Q5VWM5 PRAM9_HUMAN 56.881 0.972603 0.458159 PRAMEF9 - PRAME family member 9/15 - Homo sapiens (Human) - PRAMEF9 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.534 Q5VWM4 PRAM8_HUMAN 48.773 0.915094 0.670886 PRAMEF8 - PRAME family member 8 - Homo sapiens (Human) - PRAMEF8 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.535 O95522 PRA12_HUMAN 53.830 0.977035 0.991718 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.536 O95522 PRA12_HUMAN 52.871 0.974057 0.877847 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.537 P78395 PRAME_HUMAN 52.049 0.981172 0.939096 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Taurus_UMD|evm.model.AC_000173.1.538 Q5VXH4 PRAM6_HUMAN 50.317 0.974948 1.0063 PRAMEF6 - PRAME family member 6 - Homo sapiens (Human) - PRAMEF6 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.539 H0Y7S4 PRA26_HUMAN 53.617 0.829268 0.643979 PRAMEF26 - Putative PRAME family member 26 - Homo sapiens (Human) - PRAMEF26 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.540 A3QJZ7 PRA27_HUMAN 55.504 0.878914 1.00209 PRAMEF27 - PRAME family member 27 - Homo sapiens (Human) - PRAMEF27 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.541 O95522 PRA12_HUMAN 63.542 0.111502 1.76398 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.542 Q5VXH4 PRAM6_HUMAN 54.158 0.966527 1.0042 PRAMEF6 - PRAME family member 6 - Homo sapiens (Human) - PRAMEF6 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.543 O95522 PRA12_HUMAN 51.592 0.993631 0.975155 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.544 O95522 PRA12_HUMAN 58.378 0.973118 0.385093 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.545 O95522 PRA12_HUMAN 56.000 0.764103 0.403727 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Taurus_UMD|evm.model.AC_000173.1.546 Q60972 RBBP4_MOUSE 94.477 0.993958 0.778824 Rbbp4 - Histone-binding protein RBBP4 - Mus musculus (Mouse) - Rbbp4 gene Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Taurus_UMD|evm.model.AC_000173.1.547 Q2TA11 CA158_BOVIN 100.000 0.989848 1.0051 Uncharacterized protein C1orf158 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000173.1.548 Q5VUY0 ADCL3_HUMAN 69.403 0.98044 1.00491 AADACL3 - Arylacetamide deacetylase-like 3 - Homo sapiens (Human) - AADACL3 gene hydrolase activity Taurus_UMD|evm.model.AC_000173.1.549 Q5RFL9 NONO_PONAB 94.175 0.864407 0.250531 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Taurus_UMD|evm.model.AC_000173.1.550 O77834 PRDX6_BOVIN 100.000 0.991111 1.00446 PRDX6 - Peroxiredoxin-6 - Bos taurus (Bovine) - PRDX6 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10409692, PubMed:2373154). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10409692). Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10409692, PubMed:2373154, PubMed:9787801). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity). Taurus_UMD|evm.model.AC_000173.1.551 Q5TZF3 ANR45_HUMAN 85.317 0.166999 5.65038 ANKRD45 - Ankyrin repeat domain-containing protein 45 - Homo sapiens (Human) - ANKRD45 gene Taurus_UMD|evm.model.AC_000173.1.553 D3Z8N4 KLH20_RAT 100.000 0.96355 1.03612 Klhl20 - Kelch-like protein 20 - Rattus norvegicus (Rat) - Klhl20 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (By similarity). Taurus_UMD|evm.model.AC_000173.1.554 Q5EA18 CENPL_BOVIN 100.000 0.994236 1.00289 CENPL - Centromere protein L - Bos taurus (Bovine) - CENPL gene Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity). Taurus_UMD|evm.model.AC_000173.1.555 A6QPU5 SYDM_BOVIN 99.846 0.996933 1.00154 DARS2 - Aspartate--tRNA ligase, mitochondrial precursor - Bos taurus (Bovine) - DARS2 gene aspartate-tRNA ligase activity, mitochondrial asparaginyl-tRNA aminoacylation Taurus_UMD|evm.model.AC_000173.1.557 Q5TC79 ZBT37_HUMAN 97.614 0.996032 1.00199 ZBTB37 - Zinc finger and BTB domain-containing protein 37 - Homo sapiens (Human) - ZBTB37 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000173.1.558 P41361 ANT3_BOVIN 99.355 0.995708 1.00215 SERPINC1 - Antithrombin-III precursor - Bos taurus (Bovine) - SERPINC1 gene Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). Taurus_UMD|evm.model.AC_000173.1.559 Q5TC82 RC3H1_HUMAN 98.542 0.979943 0.308032 RC3H1 - Roquin-1 - Homo sapiens (Human) - RC3H1 gene Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs (PubMed:25026078). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (By similarity). Together with ZC3H12A, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Able to interact with double-stranded RNA (dsRNA) (PubMed:25504471, PubMed:25026078). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Taurus_UMD|evm.model.AC_000173.1.561 Q5RCW6 RBG1L_PONAB 92.705 0.937143 0.429448 RABGAP1L - Rab GTPase-activating protein 1-like - Pongo abelii (Sumatran orangutan) - RABGAP1L gene GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). Taurus_UMD|evm.model.AC_000173.1.562 Q5RCW6 RBG1L_PONAB 99.083 0.830769 0.159509 RABGAP1L - Rab GTPase-activating protein 1-like - Pongo abelii (Sumatran orangutan) - RABGAP1L gene GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). Taurus_UMD|evm.model.AC_000173.1.563 A6QLE7 GPR52_BOVIN 99.723 0.994475 1.00277 GPR52 - G-protein coupled receptor 52 - Bos taurus (Bovine) - GPR52 gene G- protein coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization. May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum. Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation. Taurus_UMD|evm.model.AC_000173.1.564 Q5R372 RBG1L_HUMAN 98.755 0.489796 0.601227 RABGAP1L - Rab GTPase-activating protein 1-like - Homo sapiens (Human) - RABGAP1L gene GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). Taurus_UMD|evm.model.AC_000173.1.565 Q3T168 CYBP_BOVIN 100.000 0.991342 1.00435 CACYBP - Calcyclin-binding protein - Bos taurus (Bovine) - CACYBP gene May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). Taurus_UMD|evm.model.AC_000173.1.566 Q6B860 RT14_BOVIN 100.000 0.984496 1.00781 MRPS14 - 28S ribosomal protein S14, mitochondrial - Bos taurus (Bovine) - MRPS14 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit, structural constituent of ribosome, mitochondrial translation, translation Taurus_UMD|evm.model.AC_000173.1.567 Q9UQP3 TENN_HUMAN 80.453 0.761733 1.0662 TNN - Tenascin-N precursor - Homo sapiens (Human) - TNN gene Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022). Taurus_UMD|evm.model.AC_000173.1.568 Q15053 K0040_HUMAN 80.000 0.980198 1.0202 KIAA0040 - Uncharacterized protein KIAA0040 - Homo sapiens (Human) - KIAA0040 gene Taurus_UMD|evm.model.AC_000173.1.569 Q92752 TENR_HUMAN 91.384 0.998495 0.978645 TNR - Tenascin-R precursor - Homo sapiens (Human) - TNR gene Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity). Taurus_UMD|evm.model.AC_000173.1.571 Q8NHY2 COP1_HUMAN 94.422 0.997195 0.975376 COP1 - E3 ubiquitin-protein ligase COP1 - Homo sapiens (Human) - COP1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable). Taurus_UMD|evm.model.AC_000173.1.572 Q9BXP8 PAPP2_HUMAN 63.844 0.968153 0.175321 PAPPA2 - Pappalysin-2 precursor - Homo sapiens (Human) - PAPPA2 gene Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3. Taurus_UMD|evm.model.AC_000173.1.573 Q9BXP8 PAPP2_HUMAN 84.167 0.978202 0.204913 PAPPA2 - Pappalysin-2 precursor - Homo sapiens (Human) - PAPPA2 gene Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3. Taurus_UMD|evm.model.AC_000173.1.574 Q9BXP8 PAPP2_HUMAN 79.416 0.744751 0.505304 PAPPA2 - Pappalysin-2 precursor - Homo sapiens (Human) - PAPPA2 gene Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3. Taurus_UMD|evm.model.AC_000173.1.575 Q61137 ASTN1_MOUSE 97.277 0.390126 0.793395 Astn1 - Astrotactin-1 precursor - Mus musculus (Mouse) - Astn1 gene Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development. Taurus_UMD|evm.model.AC_000173.1.577 Q5RDR5 BRNP2_PONAB 87.628 0.997234 0.923372 BRINP2 - BMP/retinoic acid-inducible neural-specific protein 2 precursor - Pongo abelii (Sumatran orangutan) - BRINP2 gene Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Taurus_UMD|evm.model.AC_000173.1.578 P10575 GLRX1_BOVIN 97.170 0.981308 1.00943 GLRX - Glutaredoxin-1 - Bos taurus (Bovine) - GLRX gene Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Taurus_UMD|evm.model.AC_000173.1.579 Q75NY9 SC16B_BOVIN 96.584 0.998104 1.00285 SEC16B - Protein transport protein Sec16B - Bos taurus (Bovine) - SEC16B gene Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes. Taurus_UMD|evm.model.AC_000173.1.580 A6QQF5 QORL2_BOVIN 100.000 0.994286 1.00287 Quinone oxidoreductase-like protein 2 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000173.1.581 Q9UJF2 NGAP_HUMAN 97.551 0.859762 0.957858 RASAL2 - Ras GTPase-activating protein nGAP - Homo sapiens (Human) - RASAL2 gene Inhibitory regulator of the Ras-cyclic AMP pathway. Taurus_UMD|evm.model.AC_000173.1.582 Q6ZU45 CL20A_HUMAN 56.098 0.126562 1.6 CLEC20A - Putative C-type lectin domain family 20 member A precursor - Homo sapiens (Human) - CLEC20A gene Taurus_UMD|evm.model.AC_000173.1.583 Q2YDP6 TEX35_BOVIN 98.964 0.901408 1.00948 Tex35 - Testis-expressed protein 35 - Bos taurus (Bovine) - Tex35 gene nucleus Taurus_UMD|evm.model.AC_000173.1.586 Q86X27 RGPS2_HUMAN 98.971 0.996575 1.00172 RALGPS2 - Ras-specific guanine nucleotide-releasing factor RalGPS2 - Homo sapiens (Human) - RALGPS2 gene Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). Taurus_UMD|evm.model.AC_000173.1.587 O75063 XYLK_HUMAN 97.555 0.995122 1.00244 FAM20B - Glycosaminoglycan xylosylkinase - Homo sapiens (Human) - FAM20B gene Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized. Taurus_UMD|evm.model.AC_000173.1.588 Q9H497 TOR3A_HUMAN 76.075 0.920596 1.01511 TOR3A - Torsin-3A precursor - Homo sapiens (Human) - TOR3A gene endoplasmic reticulum, endoplasmic reticulum lumen, extracellular exosome, nuclear envelope, ATPase activity Taurus_UMD|evm.model.AC_000173.1.589 P42684 ABL2_HUMAN 96.108 0.998309 1.00085 ABL2 - Tyrosine-protein kinase ABL2 - Homo sapiens (Human) - ABL2 gene Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Taurus_UMD|evm.model.AC_000173.1.590 O77760 SOAT1_CHLAE 85.481 0.994565 1.00364 SOAT1 - Sterol O-acyltransferase 1 - Chlorocebus aethiops (Green monkey) - SOAT1 gene Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions. Taurus_UMD|evm.model.AC_000173.1.591 Q95LP5 AXDN1_MACFA 76.634 0.793605 1.20702 AXDND1 - Axonemal dynein light chain domain-containing protein 1 - Macaca fascicularis (Crab-eating macaque) - AXDND1 gene Taurus_UMD|evm.model.AC_000173.1.592 Q9NP85 PODO_HUMAN 91.233 0.947917 1.00261 NPHS2 - Podocin - Homo sapiens (Human) - NPHS2 gene Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. Taurus_UMD|evm.model.AC_000173.1.593 E1BPH3 TDRD5_BOVIN 87.716 0.997986 1.01846 TDRD5 - Tudor domain-containing protein 5 - Bos taurus (Bovine) - TDRD5 gene Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity). Taurus_UMD|evm.model.AC_000173.1.594 Q96GL9 F163A_HUMAN 91.018 0.988095 1.00599 FAM163A - Protein FAM163A - Homo sapiens (Human) - FAM163A gene Taurus_UMD|evm.model.AC_000173.1.595 Q8NFQ8 TOIP2_HUMAN 74.788 0.995745 1 TOR1AIP2 - Torsin-1A-interacting protein 2 - Homo sapiens (Human) - TOR1AIP2 gene Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. Taurus_UMD|evm.model.AC_000173.1.596 Q9H496 IFG15_HUMAN 99.237 0.984848 1.00763 TOR1AIP2 - Torsin-1A-interacting protein 2, isoform IFRG15 - Homo sapiens (Human) - TOR1AIP2 gene Taurus_UMD|evm.model.AC_000173.1.597 F1N4E5 TOIP1_BOVIN 94.959 0.996672 1.00167 TOR1AIP1 - Torsin-1A-interacting protein 1 - Bos taurus (Bovine) - TOR1AIP1 gene Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina (By similarity). Taurus_UMD|evm.model.AC_000173.1.598 Q5VT06 CE350_HUMAN 86.477 0.999359 1.00064 CEP350 - Centrosome-associated protein 350 - Homo sapiens (Human) - CEP350 gene Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). Taurus_UMD|evm.model.AC_000173.1.599 O00391 QSOX1_HUMAN 78.383 0.925081 0.821954 QSOX1 - Sulfhydryl oxidase 1 precursor - Homo sapiens (Human) - QSOX1 gene Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:30367560, PubMed:23867277). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:30367560, PubMed:22801504, PubMed:23867277). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277). Taurus_UMD|evm.model.AC_000173.1.600 P53776 LHX4_MOUSE 99.486 0.994872 1 Lhx4 - LIM/homeobox protein Lhx4 - Mus musculus (Mouse) - Lhx4 gene May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (By similarity). Taurus_UMD|evm.model.AC_000173.1.601 A2VDR2 ACBD6_BOVIN 100.000 0.995475 0.783688 ACBD6 - Acyl-CoA-binding domain-containing protein 6 - Bos taurus (Bovine) - ACBD6 gene Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids (By similarity). Taurus_UMD|evm.model.AC_000173.1.602 Q9UBH6 XPR1_HUMAN 96.160 0.986861 0.984195 XPR1 - Xenotropic and polytropic retrovirus receptor 1 - Homo sapiens (Human) - XPR1 gene Plays a role in phosphate homeostasis. Mediates phosphate export from the cell (PubMed:23791524, PubMed:25938945). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (PubMed:27080106). Taurus_UMD|evm.model.AC_000173.1.603 Q5VZ46 K1614_HUMAN 62.925 0.946399 1.00336 KIAA1614 - Uncharacterized protein KIAA1614 - Homo sapiens (Human) - KIAA1614 gene apical plasma membrane, cell cortex, nucleus, protein kinase C binding, centrosome cycle, establishment or maintenance of cell polarity, regulation of cellular localization Taurus_UMD|evm.model.AC_000173.1.604 Q5R6Q2 STX6_PONAB 89.804 0.991597 0.933333 STX6 - Syntaxin-6 - Pongo abelii (Sumatran orangutan) - STX6 gene Involved in intracellular vesicle trafficking. Taurus_UMD|evm.model.AC_000173.1.605 C1ITJ8 HMR1_BOVIN 100.000 0.994065 1.00298 MR1 - Major histocompatibility complex class I-related gene protein precursor - Bos taurus (Bovine) - MR1 gene Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers (By similarity). Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively (By similarity). May present microbial antigens to various MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin. Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells (By similarity). During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora (By similarity). Acts as an immune sensor of cancer cell metabolome. May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types (By similarity). Taurus_UMD|evm.model.AC_000173.1.606 Q5VY09 IER5_HUMAN 76.292 0.993846 0.993884 IER5 - Immediate early response gene 5 protein - Homo sapiens (Human) - IER5 gene Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed:25355627, PubMed:25816751). Mediates negative transcriptional regulation of CDC25B expression (PubMed:22132193). Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed:19238419, PubMed:22132193). Associates with chromatin to the CDC25B promoter (PubMed:22132193). Taurus_UMD|evm.model.AC_000173.1.609 Q61290 CAC1E_MOUSE 93.000 0.590062 0.0708627 Cacna1e - Voltage-dependent R-type calcium channel subunit alpha-1E - Mus musculus (Mouse) - Cacna1e gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Taurus_UMD|evm.model.AC_000173.1.610 Q15878 CAC1E_HUMAN 100.000 0.371981 0.0894942 CACNA1E - Voltage-dependent R-type calcium channel subunit alpha-1E - Homo sapiens (Human) - CACNA1E gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Taurus_UMD|evm.model.AC_000173.1.611 Q15878 CAC1E_HUMAN 99.315 0.703883 0.0890618 CACNA1E - Voltage-dependent R-type calcium channel subunit alpha-1E - Homo sapiens (Human) - CACNA1E gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Taurus_UMD|evm.model.AC_000173.1.612 Q15878 CAC1E_HUMAN 96.183 0.971726 0.871595 CACNA1E - Voltage-dependent R-type calcium channel subunit alpha-1E - Homo sapiens (Human) - CACNA1E gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Taurus_UMD|evm.model.AC_000173.1.613 Q5T619 ZN648_HUMAN 73.391 0.99646 0.994718 ZNF648 - Zinc finger protein 648 - Homo sapiens (Human) - ZNF648 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000173.1.614 P84089 ERH_MOUSE 97.222 0.972603 0.701923 Erh - Enhancer of rudimentary homolog - Mus musculus (Mouse) - Erh gene May have a role in the cell cycle. Taurus_UMD|evm.model.AC_000173.1.615 A6H767 NP1L1_BOVIN 99.725 0.942708 0.982097 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Taurus_UMD|evm.model.AC_000173.1.616 P15103 GLNA_BOVIN 100.000 0.494024 2.01877 GLUL - Glutamine synthetase - Bos taurus (Bovine) - GLUL gene Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). Taurus_UMD|evm.model.AC_000173.1.617 A5PLK6 RGSL_HUMAN 71.724 0.9973 1.03253 RGSL1 - Regulator of G-protein signaling protein-like - Homo sapiens (Human) - RGSL1 gene Taurus_UMD|evm.model.AC_000173.1.618 Q05823 RN5A_HUMAN 71.547 0.993094 0.977058 RNASEL - 2-5A-dependent ribonuclease - Homo sapiens (Human) - RNASEL gene Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length. Taurus_UMD|evm.model.AC_000173.1.619 O46471 RGS16_BOVIN 100.000 0.990148 1.00495 RGS16 - Regulator of G-protein signaling 16 - Bos taurus (Bovine) - RGS16 gene Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals. Taurus_UMD|evm.model.AC_000173.1.620 P49804 RGS8_RAT 99.444 0.98895 1.00556 Rgs8 - Regulator of G-protein signaling 8 - Rattus norvegicus (Rat) - Rgs8 gene Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling. Taurus_UMD|evm.model.AC_000173.1.621 Q29RY9 NPL_BOVIN 100.000 0.993769 1.00313 NPL - N-acetylneuraminate lyase - Bos taurus (Bovine) - NPL gene Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). Taurus_UMD|evm.model.AC_000173.1.622 Q28141 DHX9_BOVIN 99.922 0.998447 1.00078 DHX9 - ATP-dependent RNA helicase A - Bos taurus (Bovine) - DHX9 gene Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:7511411). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:7511411). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:7511411). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:7511411). Binds also to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A. Plays a role in DNA replication at origins of replication and cell cycle progression. Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1. Binds to the CDKN2A promoter. Plays several roles in post-transcriptional regulation of gene expression. In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes. As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Acts also as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition. Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA. Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability. Plays a role in mRNA translation. Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs. Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation. Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process. Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection. This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis. Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus. Taurus_UMD|evm.model.AC_000173.1.623 Q3TTP0 SHP1L_MOUSE 91.468 0.504318 0.906103 Shcbp1l - Testicular spindle-associated protein SHCBP1L - Mus musculus (Mouse) - Shcbp1l gene Testis-specific spindle-associated factor that plays a role in spermatogenesis (PubMed:24557841). In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells (PubMed:24557841). Taurus_UMD|evm.model.AC_000173.1.624 P11047 LAMC1_HUMAN 94.531 0.998757 1 LAMC1 - Laminin subunit gamma-1 precursor - Homo sapiens (Human) - LAMC1 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Taurus_UMD|evm.model.AC_000173.1.625 Q8HZI9 LAMC2_HORSE 86.661 0.998322 1.00168 LAMC2 - Laminin subunit gamma-2 precursor - Equus caballus (Horse) - LAMC2 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells. Taurus_UMD|evm.model.AC_000173.1.626 Q0VC59 NMNA2_BOVIN 100.000 0.993506 1.00326 NMNAT2 - Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 - Bos taurus (Bovine) - NMNAT2 gene Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). Taurus_UMD|evm.model.AC_000173.1.627 Q5RJH6 SMG7_MOUSE 94.829 0.998249 1.00351 Smg7 - Protein SMG7 - Mus musculus (Mouse) - Smg7 gene Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity). Taurus_UMD|evm.model.AC_000173.1.629 O77775 NCF2_BOVIN 99.810 0.996212 1.0019 NCF2 - Neutrophil cytosol factor 2 - Bos taurus (Bovine) - NCF2 gene NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Taurus_UMD|evm.model.AC_000173.1.630 Q9CPW4 ARPC5_MOUSE 100.000 0.980392 0.675497 Arpc5 - Actin-related protein 2/3 complex subunit 5 - Mus musculus (Mouse) - Arpc5 gene Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Taurus_UMD|evm.model.AC_000173.1.631 Q4KLF8 ARPC5_RAT 100.000 0.313333 0.993377 Arpc5 - Actin-related protein 2/3 complex subunit 5 - Rattus norvegicus (Rat) - Arpc5 gene Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Taurus_UMD|evm.model.AC_000173.1.632 Q8WW27 ABEC4_HUMAN 80.501 0.972826 1.00272 APOBEC4 - Putative C->U-editing enzyme APOBEC-4 - Homo sapiens (Human) - APOBEC4 gene Putative C to U editing enzyme whose physiological substrate is not yet known. Taurus_UMD|evm.model.AC_000173.1.633 Q9NZL6 RGL1_HUMAN 96.443 0.942786 1.04688 RGL1 - Ral guanine nucleotide dissociation stimulator-like 1 - Homo sapiens (Human) - RGL1 gene Probable guanine nucleotide exchange factor. Taurus_UMD|evm.model.AC_000173.1.634 Q8IYK4 GT252_HUMAN 94.089 0.99681 1.0016 COLGALT2 - Procollagen galactosyltransferase 2 precursor - Homo sapiens (Human) - COLGALT2 gene Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen. Taurus_UMD|evm.model.AC_000173.1.635 Q8R3W5 SEN15_MOUSE 89.286 0.988166 1.00595 Tsen15 - tRNA-splicing endonuclease subunit Sen15 - Mus musculus (Mouse) - Tsen15 gene Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity). Taurus_UMD|evm.model.AC_000173.1.636 Q9H246 CA021_HUMAN 99.174 0.983607 1.00826 C1orf21 - Uncharacterized protein C1orf21 - Homo sapiens (Human) - C1orf21 gene Taurus_UMD|evm.model.AC_000173.1.637 Q9BZQ6 EDEM3_HUMAN 95.927 0.997854 1 EDEM3 - ER degradation-enhancing alpha-mannosidase-like protein 3 precursor - Homo sapiens (Human) - EDEM3 gene Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity). Taurus_UMD|evm.model.AC_000173.1.638 Q9BZQ8 NIBA1_HUMAN 75.527 0.997859 1.00647 NIBAN1 - Protein Niban 1 - Homo sapiens (Human) - NIBAN1 gene Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). Taurus_UMD|evm.model.AC_000173.1.639 P47961 RS4_CRIGR 80.769 0.974684 0.30038 RPS4 - 40S ribosomal protein S4 - Cricetulus griseus (Chinese hamster) - RPS4 gene Taurus_UMD|evm.model.AC_000173.1.640 P79103 RS4_BOVIN 48.588 0.964912 0.43346 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000173.1.641 Q9CQJ4 RING2_MOUSE 99.702 0.994065 1.00298 Rnf2 - E3 ubiquitin-protein ligase RING2 - Mus musculus (Mouse) - Rnf2 gene E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15525528, PubMed:22325148, PubMed:28596365). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals (PubMed:15525528, PubMed:28596365). May be involved in the initiation of both imprinted and random X inactivation (PubMed:15525528). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:22325148, PubMed:16710298). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:15525528, PubMed:22325148, PubMed:16710298). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:16710298). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (PubMed:15525528, PubMed:16710298). Plays a role in the transcriptional repression of genes that are required for pluripotency in embryonic stem cells, thereby contributing to differentiation of the ectodermal and endodermal germ layers (PubMed:22226355). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (PubMed:24034696). Taurus_UMD|evm.model.AC_000173.1.642 A5D7S3 TRM1L_BOVIN 93.750 0.997452 1.06513 TRMT1L - TRMT1-like protein - Bos taurus (Bovine) - TRMT1L gene May play a role in motor coordination and exploratory behavior. Taurus_UMD|evm.model.AC_000173.1.643 Q5T5J6 SWT1_HUMAN 79.029 0.996678 1.00333 SWT1 - Transcriptional protein SWT1 - Homo sapiens (Human) - SWT1 gene nucleus Taurus_UMD|evm.model.AC_000173.1.644 Q920Q8 NS1BP_MOUSE 97.196 0.969743 1.0296 Ivns1abp - Influenza virus NS1A-binding protein homolog - Mus musculus (Mouse) - Ivns1abp gene Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (PubMed:12213805, PubMed:16317045). Protects cells from cell death induced by actin destabilization (PubMed:16952015). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (By similarity). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (By similarity). Inhibits pre-mRNA splicing (in vitro) (By similarity). Taurus_UMD|evm.model.AC_000173.1.645 P24049 RL17_RAT 83.582 0.496241 0.722826 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000173.1.646 Q9DC63 FBX3_MOUSE 65.487 0.713376 0.327083 Fbxo3 - F-box only protein 3 - Mus musculus (Mouse) - Fbxo3 gene Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). Taurus_UMD|evm.model.AC_000173.1.647 Q8N5G0 SIM20_HUMAN 100.000 0.970588 1.01493 SMIM20 - Small integral membrane protein 20 - Homo sapiens (Human) - SMIM20 gene Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (PubMed:26321642). Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C (PubMed:26321642). Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover (PubMed:26321642). Taurus_UMD|evm.model.AC_000173.1.648 Q96RW7 HMCN1_HUMAN 89.053 0.999622 0.938776 HMCN1 - Hemicentin-1 precursor - Homo sapiens (Human) - HMCN1 gene Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration. Taurus_UMD|evm.model.AC_000173.1.649 Q9JM99 PRG4_MOUSE 79.320 0.273791 1.21632 Prg4 - Proteoglycan 4 precursor - Mus musculus (Mouse) - Prg4 gene Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Taurus_UMD|evm.model.AC_000173.1.650 P12270 TPR_HUMAN 96.107 0.967993 1.03132 TPR - Nucleoprotein TPR - Homo sapiens (Human) - TPR gene Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:22253824 and PubMed:11952838). Plays also a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. Taurus_UMD|evm.model.AC_000173.1.651 Q5SWX8 ODR4_HUMAN 88.377 0.995624 1.00661 ODR4 - Protein odr-4 homolog - Homo sapiens (Human) - ODR4 gene May play a role in the trafficking of a subset of G-protein coupled receptors. Taurus_UMD|evm.model.AC_000173.1.652 P19632 PHOS_BOVIN 98.776 0.99187 1.00408 PDC - Phosducin - Bos taurus (Bovine) - PDC gene Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Taurus_UMD|evm.model.AC_000173.1.653 O62698 PGH2_BOVIN 99.834 0.996694 1.00166 PTGS2 - Prostaglandin G/H synthase 2 precursor - Bos taurus (Bovine) - PTGS2 gene Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins. In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids. Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response. Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols. Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation. Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(n-3)) primarily to 18S-HEPE that is further metabolized by ALOX5 and LTA4H to generate 18S-RvE1 and 18S-RvE2. In vascular endothelial cells, converts docosapentaenoate (DPA, C22:5(n-3)) to 13R-HDPA, a precursor for 13-series resolvins (RvTs) shown to activate macrophage phagocytosis during bacterial infection. In activated leukocytes, contributes to oxygenation of hydroxyeicosatetraenoates (HETE) to diHETES (5,15-diHETE and 5,11-diHETE) (By similarity). During neuroinflammation, plays a role in neuronal secretion of specialized preresolving mediators (SPMs) 15R-lipoxin A4 that regulates phagocytic microglia (By similarity). Taurus_UMD|evm.model.AC_000173.1.654 Q5R893 H2B1_PONAB 88.462 0.974684 0.626984 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000173.1.655 A4IFJ5 PA24A_BOVIN 100.000 0.997333 1.00134 PLA2G4A - Cytosolic phospholipase A2 - Bos taurus (Bovine) - PLA2G4A gene Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (By similarity). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway. In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific. Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides. Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (By similarity). Taurus_UMD|evm.model.AC_000173.1.656 Q66K74 MAP1S_HUMAN 66.667 0.765766 0.104816 MAP1S - Microtubule-associated protein 1S - Homo sapiens (Human) - MAP1S gene Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). Taurus_UMD|evm.model.AC_000173.1.657 O95069 KCNK2_HUMAN 97.393 0.789474 1.24883 KCNK2 - Potassium channel subfamily K member 2 - Homo sapiens (Human) - KCNK2 gene Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Taurus_UMD|evm.model.AC_000173.1.658 P49454 CENPF_HUMAN 73.313 0.308896 1.04689 CENPF - Centromere protein F precursor - Homo sapiens (Human) - CENPF gene Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia. Taurus_UMD|evm.model.AC_000173.1.659 Q15678 PTN14_HUMAN 94.874 0.998321 1.00337 PTPN14 - Tyrosine-protein phosphatase non-receptor type 14 - Homo sapiens (Human) - PTPN14 gene Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. Taurus_UMD|evm.model.AC_000173.1.660 Q0P585 SMYD2_BOVIN 95.154 0.995604 1.05081 SMYD2 - N-lysine methyltransferase SMYD2 - Bos taurus (Bovine) - SMYD2 gene Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. Taurus_UMD|evm.model.AC_000173.1.661 Q9H4A4 AMPB_HUMAN 77.888 0.873585 0.815385 RNPEP - Aminopeptidase B - Homo sapiens (Human) - RNPEP gene Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). Taurus_UMD|evm.model.AC_000173.1.662 A1YG61 EHF_PANPA 81.818 0.259947 1.25667 EHF - ETS homologous factor - Pan paniscus (Pygmy chimpanzee) - EHF gene Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter (By similarity). Taurus_UMD|evm.model.AC_000173.1.663 Q17QD8 G37L1_BOVIN 100.000 0.995859 1.00207 GPR37L1 - G-protein coupled receptor 37-like 1 precursor - Bos taurus (Bovine) - GPR37L1 gene G-protein coupled receptor (By similarity). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity). Taurus_UMD|evm.model.AC_000173.1.664 Q5ZKQ8 ARL8A_CHICK 100.000 0.988024 0.897849 ARL8A - ADP-ribosylation factor-like protein 8A - Gallus gallus (Chicken) - ARL8A gene Plays a role in lysosome motility. In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity). Taurus_UMD|evm.model.AC_000173.1.665 P35236 PTN7_HUMAN 89.443 0.376106 2.51111 PTPN7 - Tyrosine-protein phosphatase non-receptor type 7 - Homo sapiens (Human) - PTPN7 gene Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. Taurus_UMD|evm.model.AC_000173.1.666 Q64612 PTPRV_RAT 63.417 0.996078 0.596143 Ptprv - Receptor-type tyrosine-protein phosphatase V precursor - Rattus norvegicus (Rat) - Ptprv gene May function in signaling pathways during bone remodeling, as well as serve a broader role in cell interactions associated with differentiation in bone and testis. Associated with differentiation in bone and testis. Taurus_UMD|evm.model.AC_000173.1.667 Q9HBX8 LGR6_HUMAN 72.418 0.917241 0.89969 LGR6 - Leucine-rich repeat-containing G-protein coupled receptor 6 precursor - Homo sapiens (Human) - LGR6 gene Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. Taurus_UMD|evm.model.AC_000173.1.668 Q32LD2 UBE2T_BOVIN 100.000 0.989796 1.00513 UBE2T - Ubiquitin-conjugating enzyme E2 T - Bos taurus (Bovine) - UBE2T gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Taurus_UMD|evm.model.AC_000173.1.671 O60237 MYPT2_HUMAN 92.063 0.0872011 0.724033 PPP1R12B - Protein phosphatase 1 regulatory subunit 12B - Homo sapiens (Human) - PPP1R12B gene Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. Taurus_UMD|evm.model.AC_000173.1.673 Q8N9I0 SYT2_HUMAN 95.704 0.934831 1.06205 SYT2 - Synaptotagmin-2 - Homo sapiens (Human) - SYT2 gene Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Taurus_UMD|evm.model.AC_000173.1.674 Q92786 PROX1_HUMAN 91.497 0.997465 1.07056 PROX1 - Prospero homeobox protein 1 - Homo sapiens (Human) - PROX1 gene Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. Taurus_UMD|evm.model.AC_000173.1.678 Q96S38 KS6C1_HUMAN 89.035 0.998117 0.996248 RPS6KC1 - Ribosomal protein S6 kinase delta-1 - Homo sapiens (Human) - RPS6KC1 gene May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). Taurus_UMD|evm.model.AC_000173.1.679 A6H7I3 ANGE2_BOVIN 100.000 0.99633 1.00184 ANGEL2 - Protein angel homolog 2 - Bos taurus (Bovine) - ANGEL2 gene 3'-5'-exoribonuclease activity, mRNA 3'-UTR binding, 3'-UTR-mediated mRNA stabilization Taurus_UMD|evm.model.AC_000173.1.680 Q86V25 VASH2_HUMAN 98.592 0.994382 1.00282 VASH2 - Tubulinyl-Tyr carboxypeptidase 2 - Homo sapiens (Human) - VASH2 gene Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325). Plays a role in axon formation (PubMed:31235911). Taurus_UMD|evm.model.AC_000173.1.681 Q9Y5Y0 FLVC1_HUMAN 86.257 0.827586 1.2018 FLVCR1 - Feline leukemia virus subgroup C receptor-related protein 1 - Homo sapiens (Human) - FLVCR1 gene Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro. Taurus_UMD|evm.model.AC_000173.1.682 A1A4M4 TATD3_BOVIN 100.000 0.992701 1.00366 TATDN3 - Putative deoxyribonuclease TATDN3 - Bos taurus (Bovine) - TATDN3 gene Putative deoxyribonuclease. Taurus_UMD|evm.model.AC_000173.1.683 Q96IY1 NSL1_HUMAN 81.752 0.968085 1.00356 NSL1 - Kinetochore-associated protein NSL1 homolog - Homo sapiens (Human) - NSL1 gene Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. Taurus_UMD|evm.model.AC_000173.1.684 Q9NR55 BATF3_HUMAN 86.614 0.98374 0.968504 BATF3 - Basic leucine zipper transcriptional factor ATF-like 3 - Homo sapiens (Human) - BATF3 gene AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Taurus_UMD|evm.model.AC_000173.1.685 Q66H38 FA71B_RAT 64.609 0.411263 0.905719 Fam71b - Protein FAM71B - Rattus norvegicus (Rat) - Fam71b gene May be involved in RNA biogenesis. Taurus_UMD|evm.model.AC_000173.1.686 Q2KII1 ATF3_BOVIN 100.000 0.714286 1.39227 ATF3 - Cyclic AMP-dependent transcription factor ATF-3 - Bos taurus (Bovine) - ATF3 gene This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites (By similarity). It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (By similarity). Taurus_UMD|evm.model.AC_000173.1.687 Q1JQA5 NENF_BOVIN 100.000 0.988235 1.00592 NENF - Neudesin precursor - Bos taurus (Bovine) - NENF gene Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival (By similarity). Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Taurus_UMD|evm.model.AC_000173.1.688 Q2KHV2 PACC1_BOVIN 98.738 0.990596 0.911429 PACC1 - Proton-activated chloride channel - Bos taurus (Bovine) - PACC1 gene Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH. Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling. Taurus_UMD|evm.model.AC_000173.1.689 Q15172 2A5A_HUMAN 98.357 0.991837 1.00823 PPP2R5A - Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform - Homo sapiens (Human) - PPP2R5A gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Taurus_UMD|evm.model.AC_000173.1.690 Q9NZJ0 DTL_HUMAN 90.548 0.997264 1.00137 DTL - Denticleless protein homolog - Homo sapiens (Human) - DTL gene Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). Taurus_UMD|evm.model.AC_000173.1.691 Q1RMS6 INT7_BOVIN 100.000 0.997923 1.00104 INTS7 - Integrator complex subunit 7 - Bos taurus (Bovine) - INTS7 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex. Taurus_UMD|evm.model.AC_000173.1.692 Q92604 LGAT1_HUMAN 91.081 0.994609 1.0027 LPGAT1 - Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 - Homo sapiens (Human) - LPGAT1 gene Catalyzes the transfert of an acyl group from an acyl-CoA to a lysophosphatidylglycerol (LPG) leading to biosynthesis of phosphatidylglycerol, a precursor for cardiolipin synthesis (PubMed:15485873). Uses various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors (PubMed:15485873). Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor (PubMed:15485873). In vitro can also catalyzes the transfert of an acyl group from an acyl-CoA to a monoacylglycerol leading to diacylglycerol synthesis, a precursor of triacylglycerol and plays a role in hepatic triacylglycerol synthesis and secretion (By similarity). Prefers the sn-2-monoacylglycerol to rac-1-monoacylglycerol as acyl acceptor (By similarity). Taurus_UMD|evm.model.AC_000173.1.693 P51955 NEK2_HUMAN 92.809 0.995516 1.00225 NEK2 - Serine/threonine-protein kinase Nek2 - Homo sapiens (Human) - NEK2 gene Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Taurus_UMD|evm.model.AC_000173.1.695 Q4R6K2 ZNT1_MACFA 88.757 0.996055 1.00396 SLC30A1 - Zinc transporter 1 - Macaca fascicularis (Crab-eating macaque) - SLC30A1 gene May be involved in zinc transport out of the cell. Taurus_UMD|evm.model.AC_000173.1.696 Q7Z3Z2 RD3_HUMAN 82.653 0.989796 1.00513 RD3 - Protein RD3 - Homo sapiens (Human) - RD3 gene Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors (PubMed:29515371, PubMed:21928830, PubMed:21078983, PubMed:27471269, PubMed:30559291). Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors (PubMed:21928830, PubMed:27471269, PubMed:29515371, PubMed:30559291). Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment (PubMed:21078983). Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP (PubMed:29515371). Plays an important role for the survival of rods and cones in the retina (By similarity). Taurus_UMD|evm.model.AC_000173.1.697 Q9P2K3 RCOR3_HUMAN 99.120 0.371179 1.85051 RCOR3 - REST corepressor 3 - Homo sapiens (Human) - RCOR3 gene May act as a component of a corepressor complex that represses transcription. Taurus_UMD|evm.model.AC_000173.1.699 Q10126 YSM6_CAEEL 29.697 0.885542 0.594982 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000173.1.700 Q63472 KCNH1_RAT 99.048 0.855586 0.381497 Kcnh1 - Potassium voltage-gated channel subfamily H member 1 - Rattus norvegicus (Rat) - Kcnh1 gene Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:7925287, PubMed:9400421, PubMed:24495567, PubMed:27516594). Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity). Taurus_UMD|evm.model.AC_000173.1.701 Q63472 KCNH1_RAT 90.000 0.781046 0.318087 Kcnh1 - Potassium voltage-gated channel subfamily H member 1 - Rattus norvegicus (Rat) - Kcnh1 gene Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:7925287, PubMed:9400421, PubMed:24495567, PubMed:27516594). Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity). Taurus_UMD|evm.model.AC_000173.1.702 O18965 KCNH1_BOVIN 100.000 0.901274 0.318136 KCNH1 - Potassium voltage-gated channel subfamily H member 1 - Bos taurus (Bovine) - KCNH1 gene Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9524140). Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity). Taurus_UMD|evm.model.AC_000173.1.703 Q5VTY9 HHAT_HUMAN 85.990 0.949309 0.440162 HHAT - Protein-cysteine N-palmitoyltransferase HHAT - Homo sapiens (Human) - HHAT gene Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. May bind GTP. Taurus_UMD|evm.model.AC_000173.1.704 Q9NUC0 SRTD4_HUMAN 92.416 0.994334 0.991573 SERTAD4 - SERTA domain-containing protein 4 - Homo sapiens (Human) - SERTAD4 gene Taurus_UMD|evm.model.AC_000173.1.705 Q8NB59 SYT14_HUMAN 97.495 0.603535 1.42703 SYT14 - Synaptotagmin-14 - Homo sapiens (Human) - SYT14 gene May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent. Taurus_UMD|evm.model.AC_000173.1.707 Q68CQ4 DIEXF_HUMAN 91.402 0.997347 0.997354 UTP25 - U3 small nucleolar RNA-associated protein 25 homolog - Homo sapiens (Human) - UTP25 gene Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity). Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (PubMed:25007945, PubMed:27657329, PubMed:23357851). Also involved in the sympathetic neuronal development (By similarity). Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329). Taurus_UMD|evm.model.AC_000173.1.708 Q08DD6 IRF6_BOVIN 100.000 0.995726 1.00214 IRF6 - Interferon regulatory factor 6 - Bos taurus (Bovine) - IRF6 gene Probable DNA-binding transcriptional activator. It is a key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity). Taurus_UMD|evm.model.AC_000173.1.709 A6QQA5 CA074_BOVIN 100.000 0.992424 1.0038 UPF0739 protein C1orf74 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000173.1.710 P51975 DHI1_SHEEP 96.139 0.267081 3.30822 HSD11B1 - Corticosteroid 11-beta-dehydrogenase isozyme 1 - Ovis aries (Sheep) - HSD11B1 gene Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone (By similarity). Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity). Taurus_UMD|evm.model.AC_000173.1.711 P27469 G0S2_HUMAN 63.107 0.979798 0.961165 G0S2 - G0/G1 switch protein 2 - Homo sapiens (Human) - G0S2 gene Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. Taurus_UMD|evm.model.AC_000173.1.713 Q13751 LAMB3_HUMAN 84.386 0.998295 1.00085 LAMB3 - Laminin subunit beta-3 precursor - Homo sapiens (Human) - LAMB3 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Taurus_UMD|evm.model.AC_000173.1.714 Q96NX5 KCC1G_HUMAN 91.824 0.995789 0.997899 CAMK1G - Calcium/calmodulin-dependent protein kinase type 1G - Homo sapiens (Human) - CAMK1G gene Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity). Taurus_UMD|evm.model.AC_000173.1.720 O75051 PLXA2_HUMAN 99.674 0.216714 0.745512 PLXNA2 - Plexin-A2 precursor - Homo sapiens (Human) - PLXNA2 gene Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). Taurus_UMD|evm.model.AC_000173.1.721 Q28270 CD34_CANLF 65.526 0.963446 0.984576 CD34 - Hematopoietic progenitor cell antigen CD34 precursor - Canis lupus familiaris (Dog) - CD34 gene Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity). Taurus_UMD|evm.model.AC_000173.1.725 Q6VE48 MCP_BOVIN 89.764 0.938119 1.11911 CD46 - Membrane cofactor protein precursor - Bos taurus (Bovine) - CD46 gene Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity). In case of bovine viral diarrhea virus (BVDV) infection, involved in virus attachment to cells. Taurus_UMD|evm.model.AC_000173.1.726 O02839 MCP_PIG 50.916 0.449715 1.45179 CD46 - Membrane cofactor protein precursor - Sus scrofa (Pig) - CD46 gene Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. Taurus_UMD|evm.model.AC_000173.1.727 Q6VE48 MCP_BOVIN 46.857 0.729614 1.29086 CD46 - Membrane cofactor protein precursor - Bos taurus (Bovine) - CD46 gene Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity). In case of bovine viral diarrhea virus (BVDV) infection, involved in virus attachment to cells. Taurus_UMD|evm.model.AC_000173.1.728 P36980 FHR2_HUMAN 60.223 0.960573 1.03333 CFHR2 - Complement factor H-related protein 2 precursor - Homo sapiens (Human) - CFHR2 gene Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism. Taurus_UMD|evm.model.AC_000173.1.729 P05160 F13B_HUMAN 74.923 0.491667 1.99697 F13B - Coagulation factor XIII B chain precursor - Homo sapiens (Human) - F13B gene The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Taurus_UMD|evm.model.AC_000173.1.730 P62285 ASPM_BOVIN 98.625 0.860683 1.07743 ASPM - Abnormal spindle-like microcephaly-associated protein homolog - Bos taurus (Bovine) - ASPM gene Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). Taurus_UMD|evm.model.AC_000173.1.731 Q5SVQ8 ZBT41_HUMAN 96.552 0.997006 0.734873 ZBTB41 - Zinc finger and BTB domain-containing protein 41 - Homo sapiens (Human) - ZBTB41 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000173.1.732 P82279 CRUM1_HUMAN 71.591 0.998581 1.00213 CRB1 - Protein crumbs homolog 1 precursor - Homo sapiens (Human) - CRB1 gene Plays a role in photoreceptor morphogenesis in the retina (By similarity). May maintain cell polarization and adhesion (By similarity). Taurus_UMD|evm.model.AC_000173.1.734 Q6P3S1 DEN1B_HUMAN 73.698 0.991111 0.870968 DENND1B - DENN domain-containing protein 1B - Homo sapiens (Human) - DENND1B gene Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). Taurus_UMD|evm.model.AC_000173.1.736 Q5VUE5 CA053_HUMAN 72.566 0.674699 1.14483 C1orf53 - Uncharacterized protein C1orf53 - Homo sapiens (Human) - C1orf53 gene Taurus_UMD|evm.model.AC_000173.1.737 A0JNI8 LHX9_BOVIN 100.000 0.994975 1.00252 LHX9 - LIM/homeobox protein Lhx9 - Bos taurus (Bovine) - LHX9 gene Involved in gonadal development. Taurus_UMD|evm.model.AC_000173.1.739 Q8TDX7 NEK7_HUMAN 75.166 0.991304 0.761589 NEK7 - Serine/threonine-protein kinase Nek7 - Homo sapiens (Human) - NEK7 gene Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:17586473, PubMed:19414596). Phosphorylates RPS6KB1 (By similarity). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). Taurus_UMD|evm.model.AC_000173.1.741 Q96LB4 VATG3_HUMAN 78.632 0.97479 1.00847 ATP6V1G3 - V-type proton ATPase subunit G 3 - Homo sapiens (Human) - ATP6V1G3 gene Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Taurus_UMD|evm.model.AC_000173.1.742 P08575 PTPRC_HUMAN 68.584 0.979039 0.876723 PTPRC - Receptor-type tyrosine-protein phosphatase C precursor - Homo sapiens (Human) - PTPRC gene Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). Taurus_UMD|evm.model.AC_000173.1.746 Q5RCP8 H2B2E_PONAB 45.185 0.983051 0.936508 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000173.1.749 O00482 NR5A2_HUMAN 97.006 0.996016 0.927911 NR5A2 - Nuclear receptor subfamily 5 group A member 2 - Homo sapiens (Human) - NR5A2 gene Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38 (By similarity). Taurus_UMD|evm.model.AC_000173.1.752 Q9Y2X9 ZN281_HUMAN 94.624 0.995708 0.52067 ZNF281 - Zinc finger protein 281 - Homo sapiens (Human) - ZNF281 gene Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. Taurus_UMD|evm.model.AC_000173.1.755 Q5T1V6 DDX59_HUMAN 77.060 0.308846 3.23263 DDX59 - Probable ATP-dependent RNA helicase DDX59 - Homo sapiens (Human) - DDX59 gene RNA binding, RNA helicase activity Taurus_UMD|evm.model.AC_000173.1.757 Q08AD1 CAMP2_HUMAN 82.692 0.0768084 0.900604 CAMSAP2 - Calmodulin-regulated spectrin-associated protein 2 - Homo sapiens (Human) - CAMSAP2 gene Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). Taurus_UMD|evm.model.AC_000173.1.758 O00155 GPR25_HUMAN 81.250 0.488055 0.811634 GPR25 - Probable G-protein coupled receptor 25 - Homo sapiens (Human) - GPR25 gene Orphan receptor. Taurus_UMD|evm.model.AC_000173.1.760 Q3KP66 INAVA_HUMAN 74.945 0.981859 0.665158 INAVA - Innate immunity activator protein - Homo sapiens (Human) - INAVA gene Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). Taurus_UMD|evm.model.AC_000173.1.762 O75037 KI21B_HUMAN 89.068 0.965732 0.19609 KIF21B - Kinesin-like protein KIF21B - Homo sapiens (Human) - KIF21B gene Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. Taurus_UMD|evm.model.AC_000173.1.763 O75037 KI21B_HUMAN 81.801 0.957992 0.596213 KIF21B - Kinesin-like protein KIF21B - Homo sapiens (Human) - KIF21B gene Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. Taurus_UMD|evm.model.AC_000173.1.764 Q08AD1 CAMP2_HUMAN 87.640 0.556962 0.106111 CAMSAP2 - Calmodulin-regulated spectrin-associated protein 2 - Homo sapiens (Human) - CAMSAP2 gene Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). Taurus_UMD|evm.model.AC_000173.1.765 Q13698 CAC1S_HUMAN 84.222 0.998343 0.966364 CACNA1S - Voltage-dependent L-type calcium channel subunit alpha-1S - Homo sapiens (Human) - CACNA1S gene Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. Taurus_UMD|evm.model.AC_000173.1.766 Q6XD76 ASCL4_HUMAN 79.710 0.375691 1.05233 ASCL4 - Achaete-scute homolog 4 - Homo sapiens (Human) - ASCL4 gene Could be a transcriptional regulator involved in skin development. Taurus_UMD|evm.model.AC_000173.1.767 Q9P0T7 TMEM9_HUMAN 86.111 0.615044 1.23497 TMEM9 - Proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor - Homo sapiens (Human) - TMEM9 gene Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (PubMed:30374053). By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation (PubMed:30374053). TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC (PubMed:30374053, PubMed:32380568). In the liver, involved in hepatic regeneration (PubMed:32380568). Taurus_UMD|evm.model.AC_000173.1.768 Q9CR23 TMEM9_MOUSE 96.154 0.28022 0.994536 Tmem9 - Proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor - Mus musculus (Mouse) - Tmem9 gene Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (By similarity). By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation (By similarity). TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC (PubMed:30374053, PubMed:32380568). In the liver, involved in hepatic regeneration (PubMed:32380568). Taurus_UMD|evm.model.AC_000173.1.769 Q86VF2 IGFN1_HUMAN 77.193 0.927739 0.342926 IGFN1 - Immunoglobulin-like and fibronectin type III domain-containing protein 1 - Homo sapiens (Human) - IGFN1 gene nucleus, synapse, Z disc, homophilic cell adhesion via plasma membrane adhesion molecules, retina layer formation, synapse assembly Taurus_UMD|evm.model.AC_000173.1.770 A2RUW0 MROH7_RAT 29.528 0.601504 0.355615 Mroh7 - Maestro heat-like repeat-containing protein family member 7 - Rattus norvegicus (Rat) - Mroh7 gene Taurus_UMD|evm.model.AC_000173.1.771 Q86VF2 IGFN1_HUMAN 73.622 0.882831 0.689049 IGFN1 - Immunoglobulin-like and fibronectin type III domain-containing protein 1 - Homo sapiens (Human) - IGFN1 gene nucleus, synapse, Z disc, homophilic cell adhesion via plasma membrane adhesion molecules, retina layer formation, synapse assembly Taurus_UMD|evm.model.AC_000173.1.772 Q28161 PKP1_BOVIN 80.082 0.996885 0.883081 PKP1 - Plakophilin-1 - Bos taurus (Bovine) - PKP1 gene Seems to play a role in junctional plaques. Taurus_UMD|evm.model.AC_000174.1.1 B4DYI2 S31C2_HUMAN 45.833 0.207947 0.665785 SPATA31C2 - Putative spermatogenesis-associated protein 31C2 - Homo sapiens (Human) - SPATA31C2 gene May play a role in spermatogenesis. Taurus_UMD|evm.model.AC_000174.1.2 Q5RCG1 TM192_PONAB 83.650 0.984962 0.98155 TMEM192 - Transmembrane protein 192 - Pongo abelii (Sumatran orangutan) - TMEM192 gene Taurus_UMD|evm.model.AC_000174.1.3 P05386 RLA1_HUMAN 57.018 0.978723 0.824561 RPLP1 - 60S acidic ribosomal protein P1 - Homo sapiens (Human) - RPLP1 gene Plays an important role in the elongation step of protein synthesis. Taurus_UMD|evm.model.AC_000174.1.4 O95198 KLHL2_HUMAN 98.651 0.996633 1.00169 KLHL2 - Kelch-like protein 2 - Homo sapiens (Human) - KLHL2 gene Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. Taurus_UMD|evm.model.AC_000174.1.5 Q5R574 MSMO1_PONAB 95.222 0.993197 1.00341 MSMO1 - Methylsterol monooxygenase 1 - Pongo abelii (Sumatran orangutan) - MSMO1 gene Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol. Taurus_UMD|evm.model.AC_000174.1.6 P04836 CBPE_BOVIN 100.000 0.995798 1.00211 CPE - Carboxypeptidase E precursor - Bos taurus (Bovine) - CPE gene Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. Taurus_UMD|evm.model.AC_000174.1.7 Q9HBF4 ZFYV1_HUMAN 93.805 0.865385 0.33462 ZFYVE1 - Zinc finger FYVE domain-containing protein 1 - Homo sapiens (Human) - ZFYVE1 gene Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241). Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11739631, PubMed:11256955). Taurus_UMD|evm.model.AC_000174.1.8 Q5RFL4 ZFYV1_PONAB 63.930 0.931148 0.386565 ZFYVE1 - Zinc finger FYVE domain-containing protein 1 - Pongo abelii (Sumatran orangutan) - ZFYVE1 gene Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity). Regulates the morphology, size and distribution of LDs (By similarity). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contact sites by forming a complex with RAB18 and ZW10 (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (By similarity). Taurus_UMD|evm.model.AC_000174.1.10 O43897 TLL1_HUMAN 76.804 0.954298 0.907206 TLL1 - Tolloid-like protein 1 precursor - Homo sapiens (Human) - TLL1 gene Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. Taurus_UMD|evm.model.AC_000174.1.11 Q49MG5 MAP9_HUMAN 72.570 0.991247 0.706337 MAP9 - Microtubule-associated protein 9 - Homo sapiens (Human) - MAP9 gene Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules. Taurus_UMD|evm.model.AC_000174.1.13 P79113 NPY2R_BOVIN 99.738 0.994778 0.997396 NPY2R - Neuropeptide Y receptor type 2 - Bos taurus (Bovine) - NPY2R gene Receptor for neuropeptide Y and peptide YY. Taurus_UMD|evm.model.AC_000174.1.15 Q8TBY0 RBM46_HUMAN 97.863 0.960905 0.91182 RBM46 - Probable RNA-binding protein 46 - Homo sapiens (Human) - RBM46 gene nucleus, mRNA binding, RNA binding Taurus_UMD|evm.model.AC_000174.1.16 Q9BGL2 LRAT_BOVIN 95.187 0.652482 1.22609 LRAT - Lecithin retinol acyltransferase - Bos taurus (Bovine) - LRAT gene Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters (PubMed:9920938, PubMed:2722792). Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity). Taurus_UMD|evm.model.AC_000174.1.17 P12799 FIBG_BOVIN 98.161 0.990826 0.981982 FGG - Fibrinogen gamma-B chain precursor - Bos taurus (Bovine) - FGG gene Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. Taurus_UMD|evm.model.AC_000174.1.18 P02672 FIBA_BOVIN 98.366 0.729117 1.3626 FGA - Fibrinogen alpha chain precursor - Bos taurus (Bovine) - FGA gene Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. Taurus_UMD|evm.model.AC_000174.1.19 P02676 FIBB_BOVIN 99.573 0.941532 1.05983 FGB - Fibrinogen beta chain precursor - Bos taurus (Bovine) - FGB gene Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. Taurus_UMD|evm.model.AC_000174.1.20 Q2KID6 PLRG1_BOVIN 100.000 0.996109 1.00195 PLRG1 - Pleiotropic regulator 1 - Bos taurus (Bovine) - PLRG1 gene Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Taurus_UMD|evm.model.AC_000174.1.21 Q6V1P9 PCD23_HUMAN 79.826 0.931034 0.21507 DCHS2 - Protocadherin-23 - Homo sapiens (Human) - DCHS2 gene Calcium-dependent cell-adhesion protein. Taurus_UMD|evm.model.AC_000174.1.22 Q6V1P9 PCD23_HUMAN 77.509 0.988967 0.806586 DCHS2 - Protocadherin-23 - Homo sapiens (Human) - DCHS2 gene Calcium-dependent cell-adhesion protein. Taurus_UMD|evm.model.AC_000174.1.23 Q62255 SALL3_MOUSE 85.185 0.224138 0.0878788 Sall3 - Sal-like protein 3 - Mus musculus (Mouse) - Sall3 gene Probable transcription factor. Taurus_UMD|evm.model.AC_000174.1.25 Q863H1 SFRP2_CANLF 96.939 0.99322 1.0034 SFRP2 - Secreted frizzled-related protein 2 precursor - Canis lupus familiaris (Dog) - SFRP2 gene Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. Taurus_UMD|evm.model.AC_000174.1.26 Q8N4F7 RN175_HUMAN 93.060 0.975309 0.987805 RNF175 - RING finger protein 175 - Homo sapiens (Human) - RNF175 gene endoplasmic reticulum membrane, Golgi membrane, ubiquitin protein ligase activity, endoplasmic reticulum unfolded protein response, ubiquitin-dependent ERAD pathway Taurus_UMD|evm.model.AC_000174.1.27 Q95LA9 TLR2_BOVIN 99.872 0.997452 1.00128 TLR2 - Toll-like receptor 2 precursor - Bos taurus (Bovine) - TLR2 gene Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity). Taurus_UMD|evm.model.AC_000174.1.29 Q08DV9 T131L_BOVIN 100.000 0.998713 0.972466 TMEM131L - Transmembrane protein 131-like precursor - Bos taurus (Bovine) - TMEM131L gene membrane, plasma membrane, negative regulation of canonical Wnt signaling pathway Taurus_UMD|evm.model.AC_000174.1.30 Q32L19 MND1_BOVIN 99.512 0.990291 1.00488 MND1 - Meiotic nuclear division protein 1 homolog - Bos taurus (Bovine) - MND1 gene Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (By similarity). Taurus_UMD|evm.model.AC_000174.1.31 A4IF63 TRIM2_BOVIN 100.000 0.962435 1.03763 TRIM2 - Tripartite motif-containing protein 2 - Bos taurus (Bovine) - TRIM2 gene E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Taurus_UMD|evm.model.AC_000174.1.32 Q3ULZ2 FHDC1_MOUSE 67.688 0.743321 0.912097 Fhdc1 - FH2 domain-containing protein 1 - Mus musculus (Mouse) - Fhdc1 gene Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). Taurus_UMD|evm.model.AC_000174.1.33 P53367 ARFP1_HUMAN 89.544 0.979827 0.930295 ARFIP1 - Arfaptin-1 - Homo sapiens (Human) - ARFIP1 gene Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells. Taurus_UMD|evm.model.AC_000174.1.34 Q8IY51 TIGD4_HUMAN 90.234 0.996101 1.00195 TIGD4 - Tigger transposable element-derived protein 4 - Homo sapiens (Human) - TIGD4 gene nucleus, DNA binding Taurus_UMD|evm.model.AC_000174.1.35 Q6P9G4 TM154_HUMAN 64.894 0.953125 1.04918 TMEM154 - Transmembrane protein 154 precursor - Homo sapiens (Human) - TMEM154 gene Taurus_UMD|evm.model.AC_000174.1.37 F1MNN4 FBXW7_BOVIN 100.000 0.96049 1.03966 FBXW7 - F-box/WD repeat-containing protein 7 - Bos taurus (Bovine) - FBXW7 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (By similarity). Taurus_UMD|evm.model.AC_000174.1.42 O75879 GATB_HUMAN 85.612 0.963542 1.03411 GATB - Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial precursor - Homo sapiens (Human) - GATB gene Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Taurus_UMD|evm.model.AC_000174.1.43 Q05DH4 F16A1_HUMAN 82.709 0.997118 1.00096 FHIP1A - FHF complex subunit HOOK interacting protein 1A - Homo sapiens (Human) - FHIP1A gene Probable component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:32073997). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Taurus_UMD|evm.model.AC_000174.1.44 Q7RTY5 PRS48_HUMAN 61.417 0.494118 1.55488 PRSS48 - Serine protease 48 precursor - Homo sapiens (Human) - PRSS48 gene extracellular space, serine-type endopeptidase activity, proteolysis Taurus_UMD|evm.model.AC_000174.1.45 Q5HYK7 SH319_HUMAN 80.784 0.732276 1.35696 SH3D19 - SH3 domain-containing protein 19 - Homo sapiens (Human) - SH3D19 gene May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization. Taurus_UMD|evm.model.AC_000174.1.46 P61247 RS3A_HUMAN 100.000 0.992453 1.00379 RPS3A - 40S ribosomal protein S3a - Homo sapiens (Human) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Taurus_UMD|evm.model.AC_000174.1.47 P50851 LRBA_HUMAN 83.882 0.998047 0.715334 LRBA - Lipopolysaccharide-responsive and beige-like anchor protein - Homo sapiens (Human) - LRBA gene May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules. Taurus_UMD|evm.model.AC_000174.1.48 Q8BPP1 MB212_MOUSE 100.000 0.994444 1.00279 Mab21l2 - Protein mab-21-like 2 - Mus musculus (Mouse) - Mab21l2 gene Required for several aspects of embryonic development including normal development of the eye, notochord, neural tube and other organ tissues, and for embryonic turning. Taurus_UMD|evm.model.AC_000174.1.49 D2I3C6 DCLK2_AILME 96.893 0.95788 0.938776 DCLK2 - Serine/threonine-protein kinase DCLK2 - Ailuropoda melanoleuca (Giant panda) - DCLK2 gene Protein kinase with a significantly reduced Ca(2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). Taurus_UMD|evm.model.AC_000174.1.50 A0A1B0GVH7 IQCM_HUMAN 63.312 0.915152 0.658683 IQCM - IQ domain-containing protein M - Homo sapiens (Human) - IQCM gene Taurus_UMD|evm.model.AC_000174.1.51 O15439 MRP4_HUMAN 72.727 0.159204 0.151698 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000174.1.52 O15439 MRP4_HUMAN 69.728 0.957516 0.230943 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000174.1.53 O15439 MRP4_HUMAN 86.585 0.987805 0.0618868 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000174.1.54 P08235 MCR_HUMAN 95.980 0.994962 0.403455 NR3C2 - Mineralocorticoid receptor - Homo sapiens (Human) - NR3C2 gene Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. Taurus_UMD|evm.model.AC_000174.1.55 Q08DP6 RHG10_BOVIN 100.000 0.997455 1.00127 ARHGAP10 - Rho GTPase-activating protein 10 - Bos taurus (Bovine) - ARHGAP10 gene GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Taurus_UMD|evm.model.AC_000174.1.56 Q6P2P2 ANM9_HUMAN 91.135 0.997639 1.00237 PRMT9 - Protein arginine N-methyltransferase 9 - Homo sapiens (Human) - PRMT9 gene Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed:25737013, PubMed:25979344). Taurus_UMD|evm.model.AC_000174.1.57 Q17QL9 T184C_BOVIN 100.000 0.927813 1.07534 TMEM184C - Transmembrane protein 184C - Bos taurus (Bovine) - TMEM184C gene Possible tumor suppressor which may play a role in cell growth. Taurus_UMD|evm.model.AC_000174.1.58 P21450 EDNRA_BOVIN 100.000 0.995327 1.00234 EDNRA - Endothelin-1 receptor precursor - Bos taurus (Bovine) - EDNRA gene Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Taurus_UMD|evm.model.AC_000174.1.59 Q4R6M4 TTC29_MACFA 83.932 0.912959 1.08842 TTC29 - Tetratricopeptide repeat protein 29 - Macaca fascicularis (Crab-eating macaque) - TTC29 gene Axonemal protein which is implicated in axonemal and/or peri-axonemal structures assembly and regulates flagella assembly and beating and therefore sperm motility. Taurus_UMD|evm.model.AC_000174.1.60 E1B7X3 R146A_BOVIN 100.000 0.99422 1 RNF146A - E3 ubiquitin-protein ligase RNF146-A - Bos taurus (Bovine) - RNF146A gene E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination (By similarity). Taurus_UMD|evm.model.AC_000174.1.61 Q63934 PO4F2_MOUSE 98.054 0.99511 0.995134 Pou4f2 - POU domain, class 4, transcription factor 2 - Mus musculus (Mouse) - Pou4f2 gene Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:7904822, PubMed:8995448, PubMed:8972215, PubMed:10357904, PubMed:10414983, PubMed:11163266, PubMed:17668438, PubMed:25775587). Functions either as activator or repressor by modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:7904822, PubMed:7935408, PubMed:8065921, PubMed:7852360, PubMed:7797498, PubMed:8662774, PubMed:9694219, PubMed:10526314, PubMed:15733064, PubMed:17145718, PubMed:18368538). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes (PubMed:7904822, PubMed:8290353, PubMed:9111308, PubMed:10414983, PubMed:16152597, PubMed:17668438, PubMed:24643061). Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation (PubMed:8632990, PubMed:10357904, PubMed:25775587). Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding (PubMed:8995448, PubMed:9261145, PubMed:8972215, PubMed:10357904, PubMed:11163266, PubMed:24643061, PubMed:25775587). Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification (PubMed:21875655). In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis (PubMed:17145718). Negatively regulates BAX promoter activity in the absence of TP53 (PubMed:17145718). Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter (PubMed:9448000). Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif (PubMed:7935408, PubMed:8065921, PubMed:8537352, PubMed:7852360, PubMed:8662774). Involved in TNFSF11-mediated terminal osteoclast differentiation (PubMed:17668438). Taurus_UMD|evm.model.AC_000174.1.62 Q0GE19 NTCP7_HUMAN 93.824 0.994135 1.00294 SLC10A7 - Sodium/bile acid cotransporter 7 - Homo sapiens (Human) - SLC10A7 gene Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins, to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization (PubMed:30082715, PubMed:29878199). Also involved in the regulation of cellular calcium homeostasis (PubMed:30082715, PubMed:31191616). Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate). Taurus_UMD|evm.model.AC_000174.1.64 A0A1B0GV85 RELD1_HUMAN 65.736 0.996269 1.01901 REELD1 - Reelin domain-containing protein 1 precursor - Homo sapiens (Human) - REELD1 gene Taurus_UMD|evm.model.AC_000174.1.65 P62313 LSM6_MOUSE 100.000 0.858696 1.15 Lsm6 - U6 snRNA-associated Sm-like protein LSm6 - Mus musculus (Mouse) - Lsm6 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Taurus_UMD|evm.model.AC_000174.1.66 Q17R98 ZN827_HUMAN 94.832 0.720484 0.916744 ZNF827 - Zinc finger protein 827 - Homo sapiens (Human) - ZNF827 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000174.1.67 C9J302 CD051_HUMAN 58.621 0.920904 0.876238 C4orf51 - Uncharacterized protein C4orf51 - Homo sapiens (Human) - C4orf51 gene Taurus_UMD|evm.model.AC_000174.1.68 Q8IVH4 MMAA_HUMAN 88.249 0.985782 1.00957 MMAA - Methylmalonic aciduria type A protein, mitochondrial precursor - Homo sapiens (Human) - MMAA gene GTPase, binds and hydrolyzes GTP (PubMed:28497574, PubMed:20876572, PubMed:21138732, PubMed:28943303). Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis (PubMed:28497574, PubMed:20876572). Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) (PubMed:28497574, PubMed:20876572). Plays a dual role as both a protectase and a reactivase for MMUT (PubMed:21138732, PubMed:28943303). Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl) (PubMed:21138732, PubMed:28943303). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP (PubMed:21138732, PubMed:28943303). Taurus_UMD|evm.model.AC_000174.1.69 Q1JQA2 SMAD1_BOVIN 100.000 0.995708 1.00215 SMAD1 - Mothers against decapentaplegic homolog 1 - Bos taurus (Bovine) - SMAD1 gene Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Taurus_UMD|evm.model.AC_000174.1.70 Q01804 OTUD4_HUMAN 87.612 0.998198 0.996409 OTUD4 - OTU domain-containing protein 4 - Homo sapiens (Human) - OTUD4 gene Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Taurus_UMD|evm.model.AC_000174.1.71 P61222 ABCE1_MOUSE 99.833 0.996667 1.00167 Abce1 - ATP-binding cassette sub-family E member 1 - Mus musculus (Mouse) - Abce1 gene Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (By similarity). Together with PELO and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (By similarity). Together with PELO and HBS1L, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (By similarity). Plays a role in the regulation of mRNA turnover (PubMed:10866653). Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (By similarity). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (By similarity). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (By similarity). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (By similarity). Taurus_UMD|evm.model.AC_000174.1.72 Q9UM13 APC10_HUMAN 100.000 0.560976 1.77297 ANAPC10 - Anaphase-promoting complex subunit 10 - Homo sapiens (Human) - ANAPC10 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Taurus_UMD|evm.model.AC_000174.1.73 Q96QV1 HHIP_HUMAN 93.780 0.410256 0.724286 HHIP - Hedgehog-interacting protein precursor - Homo sapiens (Human) - HHIP gene Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. Taurus_UMD|evm.model.AC_000174.1.75 P0C091 FREM3_HUMAN 75.074 0.165842 0.944367 FREM3 - FRAS1-related extracellular matrix protein 3 precursor - Homo sapiens (Human) - FREM3 gene Extracellular matrix protein which may play a role in cell adhesion. Taurus_UMD|evm.model.AC_000174.1.76 P0C091 FREM3_HUMAN 73.460 0.990566 0.0991117 FREM3 - FRAS1-related extracellular matrix protein 3 precursor - Homo sapiens (Human) - FREM3 gene Extracellular matrix protein which may play a role in cell adhesion. Taurus_UMD|evm.model.AC_000174.1.78 P0C091 FREM3_HUMAN 72.264 0.952813 0.257597 FREM3 - FRAS1-related extracellular matrix protein 3 precursor - Homo sapiens (Human) - FREM3 gene Extracellular matrix protein which may play a role in cell adhesion. Taurus_UMD|evm.model.AC_000174.1.79 P0C091 FREM3_HUMAN 66.874 0.995536 0.209444 FREM3 - FRAS1-related extracellular matrix protein 3 precursor - Homo sapiens (Human) - FREM3 gene Extracellular matrix protein which may play a role in cell adhesion. Taurus_UMD|evm.model.AC_000174.1.82 P0C091 FREM3_HUMAN 67.102 0.882812 0.179523 FREM3 - FRAS1-related extracellular matrix protein 3 precursor - Homo sapiens (Human) - FREM3 gene Extracellular matrix protein which may play a role in cell adhesion. Taurus_UMD|evm.model.AC_000174.1.83 O60264 SMCA5_HUMAN 98.194 0.998101 1.00095 SMARCA5 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 - Homo sapiens (Human) - SMARCA5 gene Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. Taurus_UMD|evm.model.AC_000174.1.84 A6QLU3 GAB1_BOVIN 100.000 0.997122 1.00144 GAB1 - GRB2-associated-binding protein 1 - Bos taurus (Bovine) - GAB1 gene Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway. Taurus_UMD|evm.model.AC_000174.1.85 Q8NB14 UBP38_HUMAN 92.802 0.998079 0.99904 USP38 - Ubiquitin carboxyl-terminal hydrolase 38 - Homo sapiens (Human) - USP38 gene Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked ubiquitin chains. Taurus_UMD|evm.model.AC_000174.1.87 Q4R4D7 INP4B_MACFA 93.665 0.237581 1.13899 INPP4B - Type II inositol 3,4-bisphosphate 4-phosphatase - Macaca fascicularis (Crab-eating macaque) - INPP4B gene Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate (By similarity). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (By similarity). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). Taurus_UMD|evm.model.AC_000174.1.88 Q28028 IL15_BOVIN 100.000 0.892086 0.858025 IL15 - Interleukin-15 precursor - Bos taurus (Bovine) - IL15 gene Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity). Taurus_UMD|evm.model.AC_000174.1.89 Q32LC9 ZN330_BOVIN 100.000 0.74186 1.34375 ZNF330 - Zinc finger protein 330 - Bos taurus (Bovine) - ZNF330 gene nucleus Taurus_UMD|evm.model.AC_000174.1.91 Q9ULK6 RN150_HUMAN 96.283 0.992593 0.616438 RNF150 - RING finger protein 150 precursor - Homo sapiens (Human) - RNF150 gene cytoplasm, ubiquitin protein ligase activity, ubiquitin-dependent protein catabolic process Taurus_UMD|evm.model.AC_000174.1.92 Q6ZT07 TBCD9_HUMAN 94.002 0.998384 0.977883 TBC1D9 - TBC1 domain family member 9 - Homo sapiens (Human) - TBC1D9 gene May act as a GTPase-activating protein for Rab family protein(s). Taurus_UMD|evm.model.AC_000174.1.93 P10861 UCP1_BOVIN 98.529 0.992565 0.87055 UCP1 - Mitochondrial brown fat uncoupling protein 1 - Bos taurus (Bovine) - UCP1 gene Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria. Taurus_UMD|evm.model.AC_000174.1.94 Q08DZ3 ELMD2_BOVIN 100.000 0.993197 1.00341 ELMOD2 - ELMO domain-containing protein 2 - Bos taurus (Bovine) - ELMOD2 gene Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Taurus_UMD|evm.model.AC_000174.1.95 A6NG13 MGT4D_HUMAN 67.112 0.988732 0.949198 MGAT4D - Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D - Homo sapiens (Human) - MGAT4D gene May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surface proteins to carry mainly high mannose N-glycans. The function is mediated by its lumenal domain and occurs specifically in the Golgi. A catalytic glucosyltransferase activity is not detected. May be involved in regulation of Sertoli-germ cell interactions during specific stages of spermatogenesis. Taurus_UMD|evm.model.AC_000174.1.96 Q3SYT6 CLGN_BOVIN 100.000 0.925076 1.07921 CLGN - Calmegin precursor - Bos taurus (Bovine) - CLGN gene Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity). Taurus_UMD|evm.model.AC_000174.1.97 Q5XJK1 SCOCB_DANRE 93.506 0.475 2.10526 scocb - Short coiled-coil protein B - Danio rerio (Zebrafish) - scocb gene Positive regulator of amino acid starvation-induced autophagy. Taurus_UMD|evm.model.AC_000174.1.98 Q96JK9 MAML3_HUMAN 88.824 0.835821 0.176626 MAML3 - Mastermind-like protein 3 - Homo sapiens (Human) - MAML3 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Taurus_UMD|evm.model.AC_000174.1.99 Q96JK9 MAML3_HUMAN 87.411 0.930799 0.901582 MAML3 - Mastermind-like protein 3 - Homo sapiens (Human) - MAML3 gene Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Taurus_UMD|evm.model.AC_000174.1.100 Q2KJG4 MGST2_BOVIN 81.507 0.983471 0.828767 MGST2 - Microsomal glutathione S-transferase 2 - Bos taurus (Bovine) - MGST2 gene Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells. Taurus_UMD|evm.model.AC_000174.1.101 Q8WTS6 SETD7_HUMAN 98.087 0.892421 1.11749 SETD7 - Histone-lysine N-methyltransferase SETD7 - Homo sapiens (Human) - SETD7 gene Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Taurus_UMD|evm.model.AC_000174.1.102 Q5R615 RB33B_PONAB 96.943 0.991304 1.00437 RAB33B - Ras-related protein Rab-33B - Pongo abelii (Sumatran orangutan) - RAB33B gene Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (By similarity). It is involved in autophagy, acting as a modulator of autophagosome formation (By similarity). Taurus_UMD|evm.model.AC_000174.1.104 Q9BXJ9 NAA15_HUMAN 99.192 0.997693 1.00115 NAA15 - N-alpha-acetyltransferase 15, NatA auxiliary subunit - Homo sapiens (Human) - NAA15 gene Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. Taurus_UMD|evm.model.AC_000174.1.106 Q02376 NDUC1_BOVIN 100.000 0.974026 1.01316 NDUFC1 - NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor - Bos taurus (Bovine) - NDUFC1 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000174.1.107 A6QLZ1 HUMMR_BOVIN 100.000 0.991701 1.00417 MGARP - Protein MGARP - Bos taurus (Bovine) - MGARP gene Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity). Taurus_UMD|evm.model.AC_000174.1.108 Q6I9Y2 THOC7_HUMAN 89.868 0.991228 1.11765 THOC7 - THO complex subunit 7 homolog - Homo sapiens (Human) - THOC7 gene Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Taurus_UMD|evm.model.AC_000174.1.109 Q7L190 DPPA4_HUMAN 54.754 0.99 0.986842 DPPA4 - Developmental pluripotency-associated protein 4 - Homo sapiens (Human) - DPPA4 gene May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage. Taurus_UMD|evm.model.AC_000174.1.110 Q15723 ELF2_HUMAN 97.138 0.996639 1.00337 ELF2 - ETS-related transcription factor Elf-2 - Homo sapiens (Human) - ELF2 gene Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter. Taurus_UMD|evm.model.AC_000174.1.111 Q9UK39 NOCT_HUMAN 95.317 0.608403 1.38051 NOCT - Nocturnin precursor - Homo sapiens (Human) - NOCT gene Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity). Taurus_UMD|evm.model.AC_000174.1.112 Q8K310 MATR3_MOUSE 89.353 0.695906 0.808511 Matr3 - Matrin-3 - Mus musculus (Mouse) - Matr3 gene May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs (By similarity). Taurus_UMD|evm.model.AC_000174.1.113 Q9UPY5 XCT_HUMAN 78.088 0.986607 0.894212 SLC7A11 - Cystine/glutamate transporter - Homo sapiens (Human) - SLC7A11 gene Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. Taurus_UMD|evm.model.AC_000174.1.114 O46415 FRIL_BOVIN 43.478 0.791111 1.28571 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000174.1.116 A7MB46 PCD18_BOVIN 99.912 0.998238 1.00088 PCDH18 - Protocadherin-18 precursor - Bos taurus (Bovine) - PCDH18 gene Potential calcium-dependent cell-adhesion protein. Taurus_UMD|evm.model.AC_000174.1.119 P21741 MK_HUMAN 91.406 0.572072 1.55245 MDK - Midkine precursor - Homo sapiens (Human) - MDK gene Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:18469519, PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:24458438, PubMed:15466886, PubMed:12084985, PubMed:10772929). Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups (PubMed:12084985, PubMed:10212223). Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:10683378, PubMed:24458438, PubMed:22323540, PubMed:12084985, PubMed:15466886, PubMed:10772929). Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378, PubMed:24458438). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively (PubMed:10683378). Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (PubMed:22323540). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (By similarity). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (By similarity). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (By similarity). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival (PubMed:10212223). Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion (PubMed:12084985, PubMed:1768439). Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (PubMed:12084985). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (By similarity). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886, PubMed:1768439). Binds LRP1; promotes neuronal survival (PubMed:10772929). Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (PubMed:12122009). Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (PubMed:18469519). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (By similarity). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (By similarity). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity). Taurus_UMD|evm.model.AC_000174.1.120 Q10126 YSM6_CAEEL 25.726 0.58046 1.24731 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000174.1.121 D3ZHA0 FLNC_RAT 95.833 0.959596 0.0363169 Flnc - Filamin-C - Rattus norvegicus (Rat) - Flnc gene Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. Taurus_UMD|evm.model.AC_000174.1.122 Q9HD36 B2L10_HUMAN 52.577 0.989189 0.906863 BCL2L10 - Bcl-2-like protein 10 - Homo sapiens (Human) - BCL2L10 gene Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (PubMed:11689480, PubMed:11278245). Increases binding of AHCYL1/IRBIT to ITPR1 (PubMed:27995898). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (PubMed:27995898). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). Taurus_UMD|evm.model.AC_000174.1.123 A5JSS2 RL21_CAPHI 48.214 0.901639 0.38125 RPL21 - 60S ribosomal protein L21 - Capra hircus (Goat) - RPL21 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000174.1.124 P0CB38 PAB4L_HUMAN 89.702 0.991914 1.0027 PABPC4L - Polyadenylate-binding protein 4-like - Homo sapiens (Human) - PABPC4L gene May bind RNA. Taurus_UMD|evm.model.AC_000174.1.125 P04764 ENOA_RAT 61.250 0.705357 0.258065 Eno1 - Alpha-enolase - Rattus norvegicus (Rat) - Eno1 gene Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. Taurus_UMD|evm.model.AC_000174.1.126 P0CW01 TSPYA_HUMAN 54.104 0.812308 1.05519 TSPY10 - Testis-specific Y-encoded protein 10 - Homo sapiens (Human) - TSPY10 gene chromatin, nucleus, chromatin binding, histone binding Taurus_UMD|evm.model.AC_000174.1.127 O19110 TSPY1_BOVIN 71.731 0.739362 1.18612 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000174.1.128 P78395 PRAME_HUMAN 60.078 0.984032 0.984283 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Taurus_UMD|evm.model.AC_000174.1.130 Q9P2E7 PCD10_HUMAN 98.558 0.998077 1 PCDH10 - Protocadherin-10 precursor - Homo sapiens (Human) - PCDH10 gene Potential calcium-dependent cell-adhesion protein. Taurus_UMD|evm.model.AC_000174.1.131 O00370 LORF2_HUMAN 61.194 0.994424 0.421961 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000174.1.132 Q3ZCH0 GRP75_BOVIN 70.940 0.956522 0.135493 HSPA9 - Stress-70 protein, mitochondrial precursor - Bos taurus (Bovine) - HSPA9 gene Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis probably via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Taurus_UMD|evm.model.AC_000174.1.133 P16423 POLR_DROME 30.263 0.778947 0.179754 pol - Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM - Drosophila melanogaster (Fruit fly) - pol gene Taurus_UMD|evm.model.AC_000174.1.134 P62828 RAN_RAT 97.000 0.916667 0.5 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Taurus_UMD|evm.model.AC_000174.1.135 Q6Q311 RS25_SHEEP 82.759 0.809524 0.84 RPS25 - 40S ribosomal protein S25 - Ovis aries (Sheep) - RPS25 gene Taurus_UMD|evm.model.AC_000174.1.136 Q4V7C7 ARP3_RAT 93.233 0.534413 0.590909 Actr3 - Actin-related protein 3 - Rattus norvegicus (Rat) - Actr3 gene ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis. Taurus_UMD|evm.model.AC_000174.1.137 Q8N1A6 CD033_HUMAN 88.095 0.988166 0.849246 C4orf33 - UPF0462 protein C4orf33 - Homo sapiens (Human) - C4orf33 gene Taurus_UMD|evm.model.AC_000174.1.138 Q96NL6 SCLT1_HUMAN 76.404 0.862745 0.148256 SCLT1 - Sodium channel and clathrin linker 1 - Homo sapiens (Human) - SCLT1 gene Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity). Taurus_UMD|evm.model.AC_000174.1.139 Q96NL6 SCLT1_HUMAN 83.860 0.996497 0.829942 SCLT1 - Sodium channel and clathrin linker 1 - Homo sapiens (Human) - SCLT1 gene Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity). Taurus_UMD|evm.model.AC_000174.1.140 Q5E9T7 JADE1_BOVIN 99.209 0.550109 1.80354 JADE1 - Protein Jade-1 - Bos taurus (Bovine) - JADE1 gene Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function. Taurus_UMD|evm.model.AC_000174.1.143 Q2KIY0 COMD6_BOVIN 98.824 0.893617 1.10588 COMMD6 - COMM domain-containing protein 6 - Bos taurus (Bovine) - COMMD6 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Inhibits TNF-induced NFKB1 activation. Taurus_UMD|evm.model.AC_000174.1.144 O15173 PGRC2_HUMAN 72.646 0.988372 0.7713 PGRMC2 - Membrane-associated progesterone receptor component 2 - Homo sapiens (Human) - PGRMC2 gene Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity). Taurus_UMD|evm.model.AC_000174.1.145 Q8BFQ4 WDR82_MOUSE 49.171 0.95082 0.389776 Wdr82 - WD repeat-containing protein 82 - Mus musculus (Mouse) - Wdr82 gene Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Possible role in telomere length maintenance and in mRNA processing (By similarity). Taurus_UMD|evm.model.AC_000174.1.146 Q58DA7 GLRX3_BOVIN 72.294 0.984375 0.57485 GLRX3 - Glutaredoxin-3 - Bos taurus (Bovine) - GLRX3 gene Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). Taurus_UMD|evm.model.AC_000174.1.147 Q659C4 LAR1B_HUMAN 93.594 0.267686 1.14442 LARP1B - La-related protein 1B - Homo sapiens (Human) - LARP1B gene nucleus, RNA binding Taurus_UMD|evm.model.AC_000174.1.148 O46414 FRIH_BOVIN 86.806 0.986207 0.801105 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000174.1.150 Q4V7A8 ABD18_RAT 89.871 0.995614 0.982759 Abhd18 - Protein ABHD18 precursor - Rattus norvegicus (Rat) - Abhd18 gene Taurus_UMD|evm.model.AC_000174.1.151 Q8NHS3 MFSD8_HUMAN 87.476 0.996154 1.00386 MFSD8 - Major facilitator superfamily domain-containing protein 8 - Homo sapiens (Human) - MFSD8 gene May be a carrier that transport small solutes by using chemiosmotic ion gradients. Taurus_UMD|evm.model.AC_000174.1.152 A2VDZ4 PLK4_BOVIN 100.000 0.997763 1.00112 PLK4 - Serine/threonine-protein kinase PLK4 - Bos taurus (Bovine) - PLK4 gene Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (By similarity). Phosphorylates CEP131 and PCM1 which is essential for proper organization and integrity of centriolar satellites (By similarity). Taurus_UMD|evm.model.AC_000174.1.153 O95757 HS74L_HUMAN 95.172 0.610723 1.53397 HSPA4L - Heat shock 70 kDa protein 4L - Homo sapiens (Human) - HSPA4L gene Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. Taurus_UMD|evm.model.AC_000174.1.154 F1MDL2 INTU_BOVIN 100.000 0.997859 1.00107 INTU - Protein inturned - Bos taurus (Bovine) - INTU gene Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). Taurus_UMD|evm.model.AC_000174.1.155 Q32L59 TMC5B_BOVIN 97.727 0.0868687 1.41026 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Taurus_UMD|evm.model.AC_000174.1.156 P14381 YTX2_XENLA 25.974 0.937888 0.123089 Transposon TX1 uncharacterized 149 kDa protein - Xenopus laevis (African clawed frog) Taurus_UMD|evm.model.AC_000174.1.157 Q6V0I7 FAT4_HUMAN 95.465 0.999599 1.0004 FAT4 - Protocadherin Fat 4 precursor - Homo sapiens (Human) - FAT4 gene Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). Taurus_UMD|evm.model.AC_000174.1.162 A5D992 SPY1_BOVIN 99.687 0.99375 1.00313 SPRY1 - Protein sprouty homolog 1 - Bos taurus (Bovine) - SPRY1 gene Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). Taurus_UMD|evm.model.AC_000174.1.163 Q8NB90 AFG2H_HUMAN 85.522 0.812903 1.21501 SPATA5 - ATPase family protein 2 homolog - Homo sapiens (Human) - SPATA5 gene ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes. May be involved in morphological and functional mitochondrial transformations during spermatogenesis. Taurus_UMD|evm.model.AC_000174.1.164 P53370 NUDT6_HUMAN 89.076 0.918605 0.816456 NUDT6 - Nucleoside diphosphate-linked moiety X motif 6 - Homo sapiens (Human) - NUDT6 gene May contribute to the regulation of cell proliferation. Taurus_UMD|evm.model.AC_000174.1.165 P03969 FGF2_BOVIN 99.355 0.987179 1.00645 FGF2 - Fibroblast growth factor 2 precursor - Bos taurus (Bovine) - FGF2 gene Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Also acts as an integrin ligand which is required for FGF2 signaling (By similarity). Binds to integrin ITGAV:ITGB3 (By similarity). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity). Functions as a potent mitogen in vitro (By similarity). Can induce angiogenesis (By similarity). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (By similarity). Taurus_UMD|evm.model.AC_000174.1.166 Q5RC62 BBS12_PONAB 74.157 0.997179 0.998592 BBS12 - Bardet-Biedl syndrome 12 protein homolog - Pongo abelii (Sumatran orangutan) - BBS12 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation. Taurus_UMD|evm.model.AC_000174.1.167 Q8K4K1 CETN4_MOUSE 86.310 0.988024 0.994048 Cetn4 - Centrin-4 - Mus musculus (Mouse) - Cetn4 gene Ca(2+)-binding protein that may be involved in basal body assembly or in a subsequent step of ciliogenesis. Taurus_UMD|evm.model.AC_000174.1.168 Q76LU5 IL21_BOVIN 100.000 0.986395 0.967105 IL21 - Interleukin-21 precursor - Bos taurus (Bovine) - IL21 gene Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity). Taurus_UMD|evm.model.AC_000174.1.169 Q96M93 ADAD1_HUMAN 93.413 0.991071 0.583333 ADAD1 - Adenosine deaminase domain-containing protein 1 - Homo sapiens (Human) - ADAD1 gene Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity). Taurus_UMD|evm.model.AC_000174.1.170 Q2LD37 K1109_HUMAN 96.164 0.999604 1.00979 KIAA1109 - Transmembrane protein KIAA1109 - Homo sapiens (Human) - KIAA1109 gene Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as regulator of phagocytosis (PubMed:31540829). Taurus_UMD|evm.model.AC_000174.1.171 A5D787 M17L2_BOVIN 93.000 0.980198 0.463303 MPV17L2 - Mpv17-like protein 2 - Bos taurus (Bovine) - MPV17L2 gene Required for the assembly and stability of the mitochondrial ribosome (By similarity). Is a positive regulator of mitochondrial protein synthesis (By similarity). Taurus_UMD|evm.model.AC_000174.1.172 Q13507 TRPC3_HUMAN 98.565 0.906623 1.10167 TRPC3 - Short transient receptor potential channel 3 - Homo sapiens (Human) - TRPC3 gene Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. Taurus_UMD|evm.model.AC_000174.1.173 P15927 RFA2_HUMAN 86.538 0.980952 0.388889 RPA2 - Replication protein A 32 kDa subunit - Homo sapiens (Human) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Taurus_UMD|evm.model.AC_000174.1.176 Q5E9S2 NFYA_BOVIN 81.061 0.992366 0.768328 NFYA - Nuclear transcription factor Y subunit alpha - Bos taurus (Bovine) - NFYA gene Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1 (By similarity). Taurus_UMD|evm.model.AC_000174.1.177 Q17QJ0 ASF1B_BOVIN 54.688 0.977778 0.445545 ASF1B - Histone chaperone ASF1B - Bos taurus (Bovine) - ASF1B gene Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (By similarity). Taurus_UMD|evm.model.AC_000174.1.179 A5A6H4 ROA1_PANTR 81.884 0.68 0.625 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Pan troglodytes (Chimpanzee) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. Taurus_UMD|evm.model.AC_000174.1.180 Q5RDY7 GNB5_PONAB 81.915 0.333333 0.790368 GNB5 - Guanine nucleotide-binding protein subunit beta-5 - Pongo abelii (Sumatran orangutan) - GNB5 gene Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). Taurus_UMD|evm.model.AC_000174.1.182 Q96KP6 TNIP3_HUMAN 71.542 0.82 0.923077 TNIP3 - TNFAIP3-interacting protein 3 - Homo sapiens (Human) - TNIP3 gene Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding. Taurus_UMD|evm.model.AC_000174.1.183 Q9P278 FNIP2_HUMAN 70.634 0.998168 0.980251 FNIP2 - Folliculin-interacting protein 2 - Homo sapiens (Human) - FNIP2 gene Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:18663353, PubMed:31672913). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:18403135). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:18403135). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:18403135). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). Taurus_UMD|evm.model.AC_000174.1.184 P26882 PPID_BOVIN 100.000 0.994609 1.0027 PPID - Peptidyl-prolyl cis-trans isomerase D - Bos taurus (Bovine) - PPID gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Taurus_UMD|evm.model.AC_000174.1.185 Q2KIG0 ETFD_BOVIN 100.000 0.996409 0.902755 ETFDH - Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor - Bos taurus (Bovine) - ETFDH gene Accepts electrons from ETF and reduces ubiquinone. Taurus_UMD|evm.model.AC_000174.1.186 Q96IK1 BOD1_HUMAN 67.857 0.591398 0.502703 BOD1 - Biorientation of chromosomes in cell division protein 1 - Homo sapiens (Human) - BOD1 gene Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. Taurus_UMD|evm.model.AC_000174.1.187 Q0II83 CD046_BOVIN 100.000 0.982456 1.00885 Uncharacterized protein C4orf46 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000174.1.188 Q9HBX9 RXFP1_HUMAN 88.142 0.997368 1.00396 RXFP1 - Relaxin receptor 1 - Homo sapiens (Human) - RXFP1 gene Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. Taurus_UMD|evm.model.AC_000174.1.189 A6QQU6 TM144_BOVIN 99.713 0.994269 1.00287 TMEM144 - Transmembrane protein 144 - Bos taurus (Bovine) - TMEM144 gene Taurus_UMD|evm.model.AC_000174.1.190 Q6UWH4 GAK1B_HUMAN 83.815 0.996154 1.00193 GASK1B - Golgi-associated kinase 1B - Homo sapiens (Human) - GASK1B gene Golgi apparatus Taurus_UMD|evm.model.AC_000174.1.191 Q5R4M0 GRIA2_PONAB 98.942 0.959368 1.0034 GRIA2 - Glutamate receptor 2 precursor - Pongo abelii (Sumatran orangutan) - GRIA2 gene Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). Taurus_UMD|evm.model.AC_000174.1.192 Q9GJS9 GLRB_BOVIN 100.000 0.42461 1.16097 GLRB - Glycine receptor subunit beta precursor - Bos taurus (Bovine) - GLRB gene Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Taurus_UMD|evm.model.AC_000174.1.193 Q9NRA1 PDGFC_HUMAN 93.064 0.866834 1.15362 PDGFC - Platelet-derived growth factor C precursor - Homo sapiens (Human) - PDGFC gene Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Taurus_UMD|evm.model.AC_000174.1.196 P43234 CATO_HUMAN 80.808 0.933121 0.978193 CTSO - Cathepsin O precursor - Homo sapiens (Human) - CTSO gene Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. Taurus_UMD|evm.model.AC_000174.1.197 Q2KIQ5 T23O_BOVIN 100.000 0.995086 1.00246 TDO2 - Tryptophan 2,3-dioxygenase - Bos taurus (Bovine) - TDO2 gene Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Taurus_UMD|evm.model.AC_000174.1.198 Q9R0W5 ASIC5_RAT 75.926 0.361486 0.59798 Asic5 - Acid-sensing ion channel 5 - Rattus norvegicus (Rat) - Asic5 gene Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium and lithium, and is inhibited by amiloride. Taurus_UMD|evm.model.AC_000174.1.199 P16068 GCYB1_BOVIN 100.000 0.996774 1.00162 GUCY1B1 - Guanylate cyclase soluble subunit beta-1 - Bos taurus (Bovine) - GUCY1B1 gene Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. Taurus_UMD|evm.model.AC_000174.1.200 P19687 GCYA1_BOVIN 100.000 0.99711 1.00145 GUCY1A1 - Guanylate cyclase soluble subunit alpha-1 - Bos taurus (Bovine) - GUCY1A1 gene Taurus_UMD|evm.model.AC_000174.1.201 Q86T29 ZN605_HUMAN 81.899 0.898531 1.16849 ZNF605 - Zinc finger protein 605 - Homo sapiens (Human) - ZNF605 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000174.1.203 P17031 ZNF26_HUMAN 90.485 0.996124 0.968105 ZNF26 - Zinc finger protein 26 - Homo sapiens (Human) - ZNF26 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000174.1.204 P51523 ZNF84_HUMAN 89.716 0.997286 0.998645 ZNF84 - Zinc finger protein 84 - Homo sapiens (Human) - ZNF84 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000174.1.206 P52738 ZN140_HUMAN 89.325 0.978632 1.02407 ZNF140 - Zinc finger protein 140 - Homo sapiens (Human) - ZNF140 gene May be involved in transcriptional regulation as a repressor. Taurus_UMD|evm.model.AC_000174.1.207 A8MT65 ZN891_HUMAN 65.278 0.995604 0.836397 ZNF891 - Zinc finger protein 891 - Homo sapiens (Human) - ZNF891 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000174.1.208 P21506 ZNF10_HUMAN 86.213 0.934426 1.06457 ZNF10 - Zinc finger protein 10 - Homo sapiens (Human) - ZNF10 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000174.1.209 Q14587 ZN268_HUMAN 80.717 0.969104 1.02534 ZNF268 - Zinc finger protein 268 - Homo sapiens (Human) - ZNF268 gene Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression. Taurus_UMD|evm.model.AC_000174.1.210 Q8WWY6 MB3L1_HUMAN 62.827 0.964286 1.01031 MBD3L1 - Methyl-CpG-binding domain protein 3-like 1 - Homo sapiens (Human) - MBD3L1 gene Transcriptional repressor. Taurus_UMD|evm.model.AC_000174.1.211 Q9GKM4 BCAT1_SHEEP 86.979 0.956757 0.961039 BCAT1 - Branched-chain-amino-acid aminotransferase, cytosolic - Ovis aries (Sheep) - BCAT1 gene Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Taurus_UMD|evm.model.AC_000174.1.212 Q8TF68 ZN384_HUMAN 53.906 0.973451 0.195841 ZNF384 - Zinc finger protein 384 - Homo sapiens (Human) - ZNF384 gene Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity). Taurus_UMD|evm.model.AC_000174.1.213 E9PGG2 ANHX_HUMAN 70.251 0.572016 1.28232 ANHX - Anomalous homeobox protein - Homo sapiens (Human) - ANHX gene nucleus, transcription regulator complex, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, eye development, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000174.1.214 Q5RF77 CHFR_PONAB 89.474 0.170181 1.16287 CHFR - E3 ubiquitin-protein ligase CHFR - Pongo abelii (Sumatran orangutan) - CHFR gene E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress. Taurus_UMD|evm.model.AC_000174.1.215 Q08378 GOGA3_HUMAN 83.656 0.990648 0.999332 GOLGA3 - Golgin subfamily A member 3 - Homo sapiens (Human) - GOLGA3 gene Golgi auto-antigen; probably involved in maintaining Golgi structure. Taurus_UMD|evm.model.AC_000174.1.216 Q86XL3 ANKL2_HUMAN 74.174 0.997925 1.02772 ANKLE2 - Ankyrin repeat and LEM domain-containing protein 2 - Homo sapiens (Human) - ANKLE2 gene Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). Taurus_UMD|evm.model.AC_000174.1.217 Q96HS1 PGAM5_HUMAN 93.080 0.993103 1.00346 PGAM5 - Serine/threonine-protein phosphatase PGAM5, mitochondrial - Homo sapiens (Human) - PGAM5 gene Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. Taurus_UMD|evm.model.AC_000174.1.218 Q2KIY1 PXMP2_BOVIN 100.000 0.989848 1.0051 PXMP2 - Peroxisomal membrane protein 2 - Bos taurus (Bovine) - PXMP2 gene Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane. Taurus_UMD|evm.model.AC_000174.1.219 Q07864 DPOE1_HUMAN 90.630 0.999136 1.01312 POLE - DNA polymerase epsilon catalytic subunit A - Homo sapiens (Human) - POLE gene Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Taurus_UMD|evm.model.AC_000174.1.220 Q9UBL9 P2RX2_HUMAN 87.696 0.915865 0.883227 P2RX2 - P2X purinoceptor 2 - Homo sapiens (Human) - P2RX2 gene Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. Taurus_UMD|evm.model.AC_000174.1.221 A6NCL2 LRCL1_HUMAN 58.824 0.364964 0.861635 LRCOL1 - Leucine-rich colipase-like protein 1 precursor - Homo sapiens (Human) - LRCOL1 gene response to food Taurus_UMD|evm.model.AC_000174.1.222 Q9HCM7 FBSL_HUMAN 64.555 0.997953 0.934928 FBRSL1 - Fibrosin-1-like protein - Homo sapiens (Human) - FBRSL1 gene RNA binding Taurus_UMD|evm.model.AC_000174.1.226 Q9HCQ5 GALT9_HUMAN 91.136 0.724346 0.824212 GALNT9 - Polypeptide N-acetylgalactosaminyltransferase 9 - Homo sapiens (Human) - GALNT9 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3. Taurus_UMD|evm.model.AC_000174.1.227 Q9BVI4 NOC4L_HUMAN 78.846 0.931694 0.709302 NOC4L - Nucleolar complex protein 4 homolog - Homo sapiens (Human) - NOC4L gene Noc4p-Nop14p complex, nucleolus, nucleoplasm, small-subunit processome, RNA binding, rRNA processing Taurus_UMD|evm.model.AC_000174.1.228 Q8N8A6 DDX51_HUMAN 82.482 0.964727 0.851351 DDX51 - ATP-dependent RNA helicase DDX51 - Homo sapiens (Human) - DDX51 gene ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Taurus_UMD|evm.model.AC_000174.1.229 Q9UET6 TRM7_HUMAN 89.189 0.992308 0.790274 FTSJ1 - Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase - Homo sapiens (Human) - FTSJ1 gene Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. Taurus_UMD|evm.model.AC_000174.1.230 Q8CHI8 EP400_MOUSE 83.871 0.306076 1.00716 Ep400 - E1A-binding protein p400 - Mus musculus (Mouse) - Ep400 gene Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Regulates transcriptional activity of ZNF42. Taurus_UMD|evm.model.AC_000174.1.231 Q9Y606 TRUA_HUMAN 81.754 0.970046 1.01639 PUS1 - tRNA pseudouridine synthase A precursor - Homo sapiens (Human) - PUS1 gene Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 RNA. Taurus_UMD|evm.model.AC_000174.1.232 O75385 ULK1_HUMAN 90.341 0.998106 1.00571 ULK1 - Serine/threonine-protein kinase ULK1 - Homo sapiens (Human) - ULK1 gene Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Taurus_UMD|evm.model.AC_000174.1.233 Q9R0S3 MMP17_MOUSE 86.296 0.910473 1.02422 Mmp17 - Matrix metalloproteinase-17 precursor - Mus musculus (Mouse) - Mmp17 gene Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin. Taurus_UMD|evm.model.AC_000174.1.234 Q12872 SFSWA_HUMAN 90.641 0.997879 0.991588 SFSWAP - Splicing factor, suppressor of white-apricot homolog - Homo sapiens (Human) - SFSWAP gene Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. Taurus_UMD|evm.model.AC_000174.1.236 A6QLU6 AGRD1_BOVIN 100.000 0.997785 1.00111 ADGRD1 - Adhesion G-protein coupled receptor D1 precursor - Bos taurus (Bovine) - ADGRD1 gene Orphan receptor. Signals via G(s)-alpha family of G-proteins. Taurus_UMD|evm.model.AC_000174.1.238 P62828 RAN_RAT 100.000 0.755682 0.814815 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Taurus_UMD|evm.model.AC_000174.1.239 Q00262 STX2_MOUSE 90.530 0.909722 0.99654 Stx2 - Syntaxin-2 - Mus musculus (Mouse) - Stx2 gene Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. Taurus_UMD|evm.model.AC_000174.1.240 Q10126 YSM6_CAEEL 25.000 0.923913 0.989247 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000174.1.242 O15034 RIMB2_HUMAN 91.538 0.173826 1.41635 RIMBP2 - RIMS-binding protein 2 - Homo sapiens (Human) - RIMBP2 gene Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B. Taurus_UMD|evm.model.AC_000174.1.243 Q9JMB7 PIWL1_MOUSE 98.028 0.99768 1 Piwil1 - Piwi-like protein 1 - Mus musculus (Mouse) - Piwil1 gene Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:11578866, PubMed:22121019, PubMed:21237665). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:11578866, PubMed:22121019, PubMed:21237665). Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:11578866, PubMed:22121019, PubMed:21237665). Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias) (PubMed:24757166). Not involved in the piRNA amplification loop, also named ping-pong amplification cycle (PubMed:22121019). Acts as an endoribonuclease that cleaves transposon messenger RNAs (PubMed:22121019). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (PubMed:16938833). Probable component of some RISC complex, which mediates RNA cleavage and translational silencing (PubMed:16938833). Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (PubMed:16787948). Required to sequester RNF8 in the cytoplasm until late spermatogenesis; RNF8 being released upon ubiquitination and degradation of PIWIL1 (PubMed:28552346). Taurus_UMD|evm.model.AC_000174.1.244 Q9ULW2 FZD10_HUMAN 95.009 0.996564 1.00172 FZD10 - Frizzled-10 precursor - Homo sapiens (Human) - FZD10 gene Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Taurus_UMD|evm.model.AC_000174.1.247 Q14C87 T132D_HUMAN 78.526 0.90407 0.313012 TMEM132D - Transmembrane protein 132D precursor - Homo sapiens (Human) - TMEM132D gene May serve as a cell-surface marker for oligodendrocyte differentiation. Taurus_UMD|evm.model.AC_000174.1.248 Q14C87 T132D_HUMAN 81.395 0.461538 0.0828025 TMEM132D - Transmembrane protein 132D precursor - Homo sapiens (Human) - TMEM132D gene May serve as a cell-surface marker for oligodendrocyte differentiation. Taurus_UMD|evm.model.AC_000174.1.251 Q14C87 T132D_HUMAN 82.857 0.638889 0.0982712 TMEM132D - Transmembrane protein 132D precursor - Homo sapiens (Human) - TMEM132D gene May serve as a cell-surface marker for oligodendrocyte differentiation. Taurus_UMD|evm.model.AC_000174.1.252 Q14C87 T132D_HUMAN 84.906 0.593023 0.078253 TMEM132D - Transmembrane protein 132D precursor - Homo sapiens (Human) - TMEM132D gene May serve as a cell-surface marker for oligodendrocyte differentiation. Taurus_UMD|evm.model.AC_000174.1.253 Q14C87 T132D_HUMAN 85.323 0.979398 0.574158 TMEM132D - Transmembrane protein 132D precursor - Homo sapiens (Human) - TMEM132D gene May serve as a cell-surface marker for oligodendrocyte differentiation. Taurus_UMD|evm.model.AC_000174.1.254 Q5RAF1 GL1D1_PONAB 74.566 0.993399 0.875723 GLT1D1 - Glycosyltransferase 1 domain-containing protein 1 precursor - Pongo abelii (Sumatran orangutan) - GLT1D1 gene Taurus_UMD|evm.model.AC_000174.1.255 A6QQL0 S15A4_BOVIN 100.000 0.995671 0.816254 SLC15A4 - Solute carrier family 15 member 4 - Bos taurus (Bovine) - SLC15A4 gene Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response. Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (By similarity). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand. Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (By similarity). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation. Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity). Taurus_UMD|evm.model.AC_000174.1.257 Q8N3T6 T132C_HUMAN 81.356 0.820717 0.453069 TMEM132C - Transmembrane protein 132C precursor - Homo sapiens (Human) - TMEM132C gene Taurus_UMD|evm.model.AC_000174.1.258 Q14DG7 T132B_HUMAN 84.106 0.672646 0.206865 TMEM132B - Transmembrane protein 132B - Homo sapiens (Human) - TMEM132B gene Taurus_UMD|evm.model.AC_000174.1.259 Q14DG7 T132B_HUMAN 56.140 0.186667 0.278293 TMEM132B - Transmembrane protein 132B - Homo sapiens (Human) - TMEM132B gene Taurus_UMD|evm.model.AC_000174.1.261 O19110 TSPY1_BOVIN 66.667 0.280172 0.731861 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000174.1.262 P78395 PRAME_HUMAN 66.667 0.9625 0.157171 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Taurus_UMD|evm.model.AC_000174.1.263 P78395 PRAME_HUMAN 68.519 0.263682 0.394892 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Taurus_UMD|evm.model.AC_000174.1.264 P78395 PRAME_HUMAN 51.648 0.816514 0.214145 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Taurus_UMD|evm.model.AC_000174.1.265 O19110 TSPY1_BOVIN 73.171 0.47929 0.533123 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000174.1.266 Q96LI6 HSFY1_HUMAN 54.264 0.373134 0.835411 HSFY1 - Heat shock transcription factor, Y-linked - Homo sapiens (Human) - HSFY1 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000174.1.267 P61078 UB2D3_RAT 95.918 0.986486 1.0068 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Taurus_UMD|evm.model.AC_000174.1.268 O19110 TSPY1_BOVIN 69.811 0.803922 0.9653 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000174.1.269 O19110 TSPY1_BOVIN 55.303 0.775148 0.533123 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000174.1.270 O19110 TSPY1_BOVIN 64.539 0.59322 0.744479 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000174.1.271 O19110 TSPY1_BOVIN 70.769 0.438356 0.460568 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000174.1.272 P78395 PRAME_HUMAN 62.327 0.96374 1.02947 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Taurus_UMD|evm.model.AC_000174.1.273 P78395 PRAME_HUMAN 66.310 0.869159 0.420432 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Taurus_UMD|evm.model.AC_000174.1.274 Q96LI6 HSFY1_HUMAN 64.238 0.886905 0.418953 HSFY1 - Heat shock transcription factor, Y-linked - Homo sapiens (Human) - HSFY1 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000174.1.275 O19110 TSPY1_BOVIN 51.479 0.523364 1.01262 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000174.1.276 O19110 TSPY1_BOVIN 45.161 0.836842 0.599369 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000174.1.277 O19110 TSPY1_BOVIN 35.094 0.712329 0.921136 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000174.1.278 O19110 TSPY1_BOVIN 72.308 0.42953 0.470032 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000174.1.279 O19110 TSPY1_BOVIN 68.750 0.5 0.29653 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000174.1.280 O19110 TSPY1_BOVIN 55.000 0.939189 0.466877 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000174.1.281 Q86YH2 Z280B_HUMAN 70.370 0.926357 0.475138 ZNF280B - Zinc finger protein 280B - Homo sapiens (Human) - ZNF280B gene May function as a transcription factor. Taurus_UMD|evm.model.AC_000174.1.282 Q86YH2 Z280B_HUMAN 64.593 0.277586 1.06814 ZNF280B - Zinc finger protein 280B - Homo sapiens (Human) - ZNF280B gene May function as a transcription factor. Taurus_UMD|evm.model.AC_000174.1.283 P62264 RS14_MOUSE 92.143 0.914474 1.00662 Rps14 - 40S ribosomal protein S14 - Mus musculus (Mouse) - Rps14 gene cytosol, cytosolic small ribosomal subunit, mitochondrion, nucleolus, postsynaptic density, mRNA 5'-UTR binding, RNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome, translation regulator activity Taurus_UMD|evm.model.AC_000174.1.284 P78395 PRAME_HUMAN 54.305 0.861272 0.339882 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Taurus_UMD|evm.model.AC_000174.1.285 Q5VWM4 PRAM8_HUMAN 61.157 0.358209 0.706751 PRAMEF8 - PRAME family member 8 - Homo sapiens (Human) - PRAMEF8 gene cytoplasm Taurus_UMD|evm.model.AC_000174.1.286 O19110 TSPY1_BOVIN 60.219 0.688705 1.14511 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000174.1.289 F1M3J4 MRP4_RAT 74.219 0.542735 0.176604 Abcc4 - ATP-binding cassette subfamily C member 4 - Rattus norvegicus (Rat) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Taurus_UMD|evm.model.AC_000174.1.290 Q14DG7 T132B_HUMAN 89.893 0.553011 1.09369 TMEM132B - Transmembrane protein 132B - Homo sapiens (Human) - TMEM132B gene Taurus_UMD|evm.model.AC_000174.1.291 Q9N0E1 AACS_MACFA 91.964 0.997028 1.00149 AACS - Acetoacetyl-CoA synthetase - Macaca fascicularis (Crab-eating macaque) - AACS gene Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). Taurus_UMD|evm.model.AC_000174.1.292 Q8WY22 BRI3B_HUMAN 85.657 0.99177 0.968127 BRI3BP - BRI3-binding protein - Homo sapiens (Human) - BRI3BP gene Involved in tumorigenesis and may function by stabilizing p53/TP53. Taurus_UMD|evm.model.AC_000174.1.293 Q8IY37 DHX37_HUMAN 85.060 0.99827 0.999136 DHX37 - Probable ATP-dependent RNA helicase DHX37 - Homo sapiens (Human) - DHX37 gene ATP-binding RNA helicase that plays a role in maturation of the small ribosomal subunit in ribosome biogenesis (PubMed:30582406). Required for the release of the U3 snoRNP from pre-ribosomal particles (PubMed:30582406). Plays a role in early testis development (PubMed:31287541, PubMed:31337883). Probably plays also a role in brain development (PubMed:31256877). Taurus_UMD|evm.model.AC_000174.1.294 P62976 UBIQP_CRIGR 99.340 0.95873 0.478723 Polyubiquitin precursor - Cricetulus griseus (Chinese hamster) Taurus_UMD|evm.model.AC_000174.1.295 O18824 SCRB1_BOVIN 100.000 0.919132 0.996071 SCARB1 - Scavenger receptor class B member 1 - Bos taurus (Bovine) - SCARB1 gene Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Taurus_UMD|evm.model.AC_000174.1.297 Q9Y618 NCOR2_HUMAN 87.915 0.999221 1.02108 NCOR2 - Nuclear receptor corepressor 2 - Homo sapiens (Human) - NCOR2 gene Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Taurus_UMD|evm.model.AC_000174.1.299 Q6ZTI6 RFLA_HUMAN 83.444 0.568182 1.22222 RFLNA - Refilin-A - Homo sapiens (Human) - RFLNA gene Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells. Taurus_UMD|evm.model.AC_000174.1.302 Q8N3J9 ZN664_HUMAN 100.000 0.909091 1.09579 ZNF664 - Zinc finger protein 664 - Homo sapiens (Human) - ZNF664 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000174.1.304 Q53HC0 CCD92_HUMAN 90.476 0.993671 0.954683 CCDC92 - Coiled-coil domain-containing protein 92 - Homo sapiens (Human) - CCDC92 gene centriole, centrosome, intracellular membrane-bounded organelle, nucleoplasm, identical protein binding Taurus_UMD|evm.model.AC_000174.1.305 Q8IVF4 DYH10_HUMAN 88.552 0.983147 1.02192 DNAH10 - Dynein axonemal heavy chain 10 - Homo sapiens (Human) - DNAH10 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain. Taurus_UMD|evm.model.AC_000174.1.306 O97681 VPP2_BOVIN 100.000 0.997661 1.00117 ATP6V0A2 - V-type proton ATPase 116 kDa subunit a2 - Bos taurus (Bovine) - ATP6V0A2 gene Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). Taurus_UMD|evm.model.AC_000174.1.307 Q96GX1 TECT2_HUMAN 78.273 0.997114 0.994261 TCTN2 - Tectonic-2 precursor - Homo sapiens (Human) - TCTN2 gene Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity). Taurus_UMD|evm.model.AC_000174.1.308 Q05B56 TF2H3_BOVIN 100.000 0.993548 1.00324 GTF2H3 - General transcription factor IIH subunit 3 - Bos taurus (Bovine) - GTF2H3 gene Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Taurus_UMD|evm.model.AC_000174.1.309 Q0IIF2 EI2BA_BOVIN 100.000 0.993464 1.00328 EIF2B1 - Translation initiation factor eIF-2B subunit alpha - Bos taurus (Bovine) - EIF2B1 gene Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Taurus_UMD|evm.model.AC_000174.1.310 Q2NL08 DDX55_BOVIN 99.667 0.996678 1.00166 DDX55 - ATP-dependent RNA helicase DDX55 - Bos taurus (Bovine) - DDX55 gene Probable ATP-binding RNA helicase. Taurus_UMD|evm.model.AC_000174.1.311 Q63524 TMED2_RAT 100.000 0.990099 1.00498 Tmed2 - Transmembrane emp24 domain-containing protein 2 precursor - Rattus norvegicus (Rat) - Tmed2 gene Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing (By similarity). Taurus_UMD|evm.model.AC_000174.1.312 Q17QG3 RIPL1_BOVIN 97.810 0.995146 1.02233 RILPL1 - RILP-like protein 1 - Bos taurus (Bovine) - RILPL1 gene Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (By similarity). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (By similarity). Taurus_UMD|evm.model.AC_000174.1.313 Q1LZH0 U1SBP_BOVIN 100.000 0.99187 1.00408 SNRNP35 - U11/U12 small nuclear ribonucleoprotein 35 kDa protein - Bos taurus (Bovine) - SNRNP35 gene U12-type spliceosomal complex, mRNA binding, snRNA binding, mRNA splicing, via spliceosome Taurus_UMD|evm.model.AC_000174.1.314 A4IFK7 RIPL2_BOVIN 100.000 0.990338 1.00485 RILPL2 - RILP-like protein 2 - Bos taurus (Bovine) - RILPL2 gene Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity). Taurus_UMD|evm.model.AC_000174.1.315 Q2YDJ8 KMT5A_BOVIN 100.000 0.993808 0.917614 KMT5A - N-lysine methyltransferase KMT5A - Bos taurus (Bovine) - KMT5A gene Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. Taurus_UMD|evm.model.AC_000174.1.316 A3KN83 SBNO1_HUMAN 98.132 0.955357 1.04523 SBNO1 - Protein strawberry notch homolog 1 - Homo sapiens (Human) - SBNO1 gene nucleus, chromatin DNA binding, histone binding, regulation of transcription, DNA-templated Taurus_UMD|evm.model.AC_000174.1.317 O14519 CDKA1_HUMAN 96.522 0.982759 1.0087 CDK2AP1 - Cyclin-dependent kinase 2-associated protein 1 - Homo sapiens (Human) - CDK2AP1 gene specific inhibitor of the cell-cycle kinase CDK2. Taurus_UMD|evm.model.AC_000174.1.318 Q9H3J6 CL065_HUMAN 85.455 0.947977 1.04217 MTRFR - Mitochondrial translation release factor in rescue precursor - Homo sapiens (Human) - MTRFR gene Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation (PubMed:33243891). As heterodimer with MTRES1, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue (PubMed:33243891). Taurus_UMD|evm.model.AC_000174.1.319 Q99550 MPP9_HUMAN 82.715 0.998309 1 MPHOSPH9 - M-phase phosphoprotein 9 - Homo sapiens (Human) - MPHOSPH9 gene centriole, Golgi apparatus, membrane Taurus_UMD|evm.model.AC_000174.1.320 Q9BZ72 PITM2_HUMAN 90.593 0.998484 0.977761 PITPNM2 - Membrane-associated phosphatidylinositol transfer protein 2 - Homo sapiens (Human) - PITPNM2 gene Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. Taurus_UMD|evm.model.AC_000174.1.321 Q66PJ3 AR6P4_HUMAN 84.167 0.991379 0.551069 ARL6IP4 - ADP-ribosylation factor-like protein 6-interacting protein 4 - Homo sapiens (Human) - ARL6IP4 gene Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA. Taurus_UMD|evm.model.AC_000174.1.322 Q6N063 OGFD2_HUMAN 89.429 0.994302 1.00286 OGFOD2 - 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 - Homo sapiens (Human) - OGFOD2 gene Taurus_UMD|evm.model.AC_000174.1.323 Q9NP78 ABCB9_HUMAN 92.857 0.997406 1.00653 ABCB9 - ABC-type oligopeptide transporter ABCB9 - Homo sapiens (Human) - ABCB9 gene ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation (PubMed:15863492, PubMed:17977821, PubMed:18434309, PubMed:22641697, PubMed:25646430, PubMed:30877195, PubMed:31417173, PubMed:30353140). Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers (PubMed:15863492, PubMed:25646430). Binds and transports smaller and larger peptides with the same affinity (PubMed:31417173). Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored (PubMed:15863492, PubMed:17977821, PubMed:18434309). Taurus_UMD|evm.model.AC_000174.1.324 Q9H9H4 VP37B_HUMAN 95.455 0.927273 0.578947 VPS37B - Vacuolar protein sorting-associated protein 37B - Homo sapiens (Human) - VPS37B gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Taurus_UMD|evm.model.AC_000174.1.325 O75146 HIP1R_HUMAN 91.284 0.998126 0.999064 HIP1R - Huntingtin-interacting protein 1-related protein - Homo sapiens (Human) - HIP1R gene Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. Taurus_UMD|evm.model.AC_000174.1.326 Q6P9F0 CCD62_HUMAN 81.606 0.991163 0.99269 CCDC62 - Coiled-coil domain-containing protein 62 - Homo sapiens (Human) - CCDC62 gene Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR. Taurus_UMD|evm.model.AC_000174.1.327 Q2HJ47 DENR_BOVIN 100.000 0.781746 1.27273 DENR - Density-regulated protein - Bos taurus (Bovine) - DENR gene May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity). Taurus_UMD|evm.model.AC_000174.1.328 P62975 UBIQ_RABIT 98.684 0.210674 4.68421 Ubiquitin - Oryctolagus cuniculus (Rabbit) Taurus_UMD|evm.model.AC_000174.1.329 Q8TDS4 HCAR2_HUMAN 82.873 0.991758 1.00275 HCAR2 - Hydroxycarboxylic acid receptor 2 - Homo sapiens (Human) - HCAR2 gene Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. Taurus_UMD|evm.model.AC_000174.1.330 P50748 KNTC1_HUMAN 88.456 0.998189 1 KNTC1 - Kinetochore-associated protein 1 - Homo sapiens (Human) - KNTC1 gene Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Taurus_UMD|evm.model.AC_000174.1.331 A6QLS2 RSRC2_BOVIN 100.000 0.328383 2.78621 RSRC2 - Arginine/serine-rich coiled-coil protein 2 - Bos taurus (Bovine) - RSRC2 gene Taurus_UMD|evm.model.AC_000174.1.332 P30622 CLIP1_HUMAN 92.211 0.99861 1.0007 CLIP1 - CAP-Gly domain-containing linker protein 1 - Homo sapiens (Human) - CLIP1 gene Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Taurus_UMD|evm.model.AC_000174.1.333 Q96AX1 VP33A_HUMAN 97.970 0.921875 1.07383 VPS33A - Vacuolar protein sorting-associated protein 33A - Homo sapiens (Human) - VPS33A gene Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770). Taurus_UMD|evm.model.AC_000174.1.334 Q5RBH2 DBLOH_PONAB 89.167 0.991632 1 DIABLO - Diablo homolog, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - DIABLO gene Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) (By similarity). inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity). Taurus_UMD|evm.model.AC_000174.1.335 Q9C0J1 B3GN4_HUMAN 85.511 0.980447 0.94709 B3GNT4 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 - Homo sapiens (Human) - B3GNT4 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides. Taurus_UMD|evm.model.AC_000174.1.336 Q8N309 LRC43_HUMAN 68.976 0.9872 0.952744 LRRC43 - Leucine-rich repeat-containing protein 43 - Homo sapiens (Human) - LRRC43 gene Taurus_UMD|evm.model.AC_000174.1.338 Q9HAP2 MLXIP_HUMAN 85.581 0.997669 0.933624 MLXIP - MLX-interacting protein - Homo sapiens (Human) - MLXIP gene Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. Taurus_UMD|evm.model.AC_000174.1.339 Q4VC05 BCL7A_HUMAN 84.000 0.868996 1.09048 BCL7A - B-cell CLL/lymphoma 7 protein family member A - Homo sapiens (Human) - BCL7A gene negative regulation of transcription, DNA-templated Taurus_UMD|evm.model.AC_000174.1.340 Q5RE88 CF251_PONAB 78.995 0.871255 1.06926 CFAP251 - Cilia- and flagella-associated protein 251 - Pongo abelii (Sumatran orangutan) - CFAP251 gene Involved in spermatozoa motility (By similarity). May also regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity). Taurus_UMD|evm.model.AC_000174.1.341 Q3SZ19 PSMD9_BOVIN 100.000 0.990991 1.00452 PSMD9 - 26S proteasome non-ATPase regulatory subunit 9 - Bos taurus (Bovine) - PSMD9 gene Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process. Taurus_UMD|evm.model.AC_000174.1.343 Q5EA20 HPPD_BOVIN 100.000 0.994924 1.00254 HPD - 4-hydroxyphenylpyruvate dioxygenase - Bos taurus (Bovine) - HPD gene Key enzyme in the degradation of tyrosine. Taurus_UMD|evm.model.AC_000174.1.344 Q8CFT2 SET1B_MOUSE 95.423 0.145352 0.980856 Setd1b - Histone-lysine N-methyltransferase SETD1B - Mus musculus (Mouse) - Setd1b gene Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Taurus_UMD|evm.model.AC_000174.1.345 Q3SZA1 RHOF_BOVIN 100.000 0.990741 1.00465 RHOF - Rho-related GTP-binding protein RhoF precursor - Bos taurus (Bovine) - RHOF gene Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology (By similarity). Taurus_UMD|evm.model.AC_000174.1.346 A6QPF8 T120B_BOVIN 100.000 0.994118 1.00295 TMEM120B - Transmembrane protein 120B - Bos taurus (Bovine) - TMEM120B gene Necessary for efficient adipogenesis. Does not show ion channel activity. Taurus_UMD|evm.model.AC_000174.1.347 Q32KM6 MORN3_BOVIN 100.000 0.991736 1.00415 MORN3 - MORN repeat-containing protein 3 - Bos taurus (Bovine) - MORN3 gene Taurus_UMD|evm.model.AC_000174.1.348 Q96D31 CRCM1_HUMAN 96.040 0.993421 1.00997 ORAI1 - Calcium release-activated calcium channel protein 1 - Homo sapiens (Human) - ORAI1 gene Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928, PubMed:20354224, PubMed:26956484). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901). Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion. Taurus_UMD|evm.model.AC_000174.1.349 Q8NHM5 KDM2B_HUMAN 96.379 0.95088 1.02096 KDM2B - Lysine-specific demethylase 2B - Homo sapiens (Human) - KDM2B gene Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). Taurus_UMD|evm.model.AC_000174.1.350 Q5E9J6 RNF34_BOVIN 100.000 0.994681 1.00267 RNF34 - E3 ubiquitin-protein ligase RNF34 - Bos taurus (Bovine) - RNF34 gene E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells. Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation. Taurus_UMD|evm.model.AC_000174.1.351 Q5RE52 APC5_PONAB 97.219 0.997354 1.00132 ANAPC5 - Anaphase-promoting complex subunit 5 - Pongo abelii (Sumatran orangutan) - ANAPC5 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Taurus_UMD|evm.model.AC_000174.1.352 Q96RR4 KKCC2_HUMAN 90.625 0.977586 0.986395 CAMKK2 - Calcium/calmodulin-dependent protein kinase kinase 2 - Homo sapiens (Human) - CAMKK2 gene Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. Taurus_UMD|evm.model.AC_000174.1.353 Q5E9U1 P2RX4_BOVIN 100.000 0.994859 1.00258 P2RX4 - P2X purinoceptor 4 - Bos taurus (Bovine) - P2RX4 gene Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin (By similarity). Taurus_UMD|evm.model.AC_000174.1.354 Q99572 P2RX7_HUMAN 82.689 0.996644 1.00168 P2RX7 - P2X purinoceptor 7 - Homo sapiens (Human) - P2RX7 gene Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206). Taurus_UMD|evm.model.AC_000174.1.355 O35594 IFT81_MOUSE 90.089 0.996909 0.957101 Ift81 - Intraflagellar transport protein 81 homolog - Mus musculus (Mouse) - Ift81 gene Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Taurus_UMD|evm.model.AC_000174.1.356 P11607 AT2A2_PIG 96.353 0.998031 0.975048 ATP2A2 - Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 - Sus scrofa (Pig) - ATP2A2 gene This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes. Taurus_UMD|evm.model.AC_000174.1.357 Q9WVM3 APC7_MOUSE 98.143 0.786611 0.846018 Anapc7 - Anaphase-promoting complex subunit 7 - Mus musculus (Mouse) - Anapc7 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Taurus_UMD|evm.model.AC_000174.1.358 O15145 ARPC3_HUMAN 100.000 0.988827 1.00562 ARPC3 - Actin-related protein 2/3 complex subunit 3 - Homo sapiens (Human) - ARPC3 gene Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Taurus_UMD|evm.model.AC_000174.1.359 Q0P5E2 GPN3_BOVIN 100.000 0.992982 1.00352 GPN3 - GPN-loop GTPase 3 - Bos taurus (Bovine) - GPN3 gene Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Taurus_UMD|evm.model.AC_000174.1.360 Q3SZW6 F216A_BOVIN 100.000 0.992063 1.00398 FAM216A - Protein FAM216A - Bos taurus (Bovine) - FAM216A gene Taurus_UMD|evm.model.AC_000174.1.361 Q3T0M0 VPS29_BOVIN 100.000 0.989305 1.00538 VPS29 - Vacuolar protein sorting-associated protein 29 - Bos taurus (Bovine) - VPS29 gene Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Acts also as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27. Taurus_UMD|evm.model.AC_000174.1.362 Q5E9X8 RAD9B_BOVIN 98.801 0.978824 0.961538 RAD9B - Cell cycle checkpoint control protein RAD9B - Bos taurus (Bovine) - RAD9B gene checkpoint clamp complex, 3'-5' exonuclease activity, cellular response to ionizing radiation, DNA repair, DNA replication checkpoint, intra-S DNA damage checkpoint Taurus_UMD|evm.model.AC_000174.1.363 Q8NI37 PPTC7_HUMAN 99.023 0.993506 1.01316 PPTC7 - Protein phosphatase PTC7 homolog precursor - Homo sapiens (Human) - PPTC7 gene Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q (PubMed:30267671). Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (PubMed:30267671). Taurus_UMD|evm.model.AC_000174.1.364 Q2MV58 TECT1_HUMAN 77.500 0.996661 1.02044 TCTN1 - Tectonic-1 precursor - Homo sapiens (Human) - TCTN1 gene Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity). Taurus_UMD|evm.model.AC_000174.1.365 Q96D96 HVCN1_HUMAN 86.545 0.971326 1.02198 HVCN1 - Voltage-gated hydrogen channel 1 - Homo sapiens (Human) - HVCN1 gene Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. Taurus_UMD|evm.model.AC_000174.1.366 P63088 PP1G_RAT 100.000 0.926036 1.04644 Ppp1cc - Serine/threonine-protein phosphatase PP1-gamma catalytic subunit - Rattus norvegicus (Rat) - Ppp1cc gene Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Taurus_UMD|evm.model.AC_000174.1.367 Q2T9W3 CCD63_BOVIN 99.820 0.805515 1.23477 CCDC63 - Coiled-coil domain-containing protein 63 - Bos taurus (Bovine) - CCDC63 gene Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads. Taurus_UMD|evm.model.AC_000174.1.368 Q3SZE5 MLRV_BOVIN 99.394 0.841026 1.1747 MYL2 - Myosin regulatory light chain 2, ventricular/cardiac muscle isoform - Bos taurus (Bovine) - MYL2 gene Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity). Taurus_UMD|evm.model.AC_000174.1.369 O14529 CUX2_HUMAN 88.904 0.994624 1.00135 CUX2 - Homeobox protein cut-like 2 - Homo sapiens (Human) - CUX2 gene Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner. Taurus_UMD|evm.model.AC_000174.1.370 Q8N4B1 SESQ1_HUMAN 60.274 0.905473 0.807229 PHETA1 - Sesquipedalian-1 - Homo sapiens (Human) - PHETA1 gene Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. Taurus_UMD|evm.model.AC_000174.1.371 Q9UQQ2 SH2B3_HUMAN 82.137 0.996593 1.02087 SH2B3 - SH2B adapter protein 3 - Homo sapiens (Human) - SH2B3 gene Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. Taurus_UMD|evm.model.AC_000174.1.372 Q99700 ATX2_HUMAN 92.012 0.989037 0.972582 ATXN2 - Ataxin-2 - Homo sapiens (Human) - ATXN2 gene Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. Taurus_UMD|evm.model.AC_000174.1.373 Q7Z569 BRAP_HUMAN 96.453 0.996627 1.00169 BRAP - BRCA1-associated protein - Homo sapiens (Human) - BRAP gene Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. Taurus_UMD|evm.model.AC_000174.1.374 Q6JQN1 ACD10_HUMAN 93.651 0.96875 0.0604344 ACAD10 - Acyl-CoA dehydrogenase family member 10 - Homo sapiens (Human) - ACAD10 gene Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA. Taurus_UMD|evm.model.AC_000174.1.375 Q6JQN1 ACD10_HUMAN 76.996 0.698925 0.70255 ACAD10 - Acyl-CoA dehydrogenase family member 10 - Homo sapiens (Human) - ACAD10 gene Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA. Taurus_UMD|evm.model.AC_000174.1.376 Q6JQN1 ACD10_HUMAN 85.147 0.996212 0.997167 ACAD10 - Acyl-CoA dehydrogenase family member 10 - Homo sapiens (Human) - ACAD10 gene Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA. Taurus_UMD|evm.model.AC_000174.1.377 P49025 CTRO_MOUSE 92.659 0.999002 0.975669 Cit - Citron Rho-interacting kinase - Mus musculus (Mouse) - Cit gene Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Probable RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. Taurus_UMD|evm.model.AC_000174.1.378 Q5BIS9 AAKB1_BOVIN 100.000 0.99262 1.0037 PRKAB1 - 5'-AMP-activated protein kinase subunit beta-1 - Bos taurus (Bovine) - PRKAB1 gene Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity). Taurus_UMD|evm.model.AC_000174.1.379 B4DJY2 TM233_HUMAN 83.962 0.963303 1 TMEM233 - Transmembrane protein 233 - Homo sapiens (Human) - TMEM233 gene membrane Taurus_UMD|evm.model.AC_000174.1.380 Q8IWA6 CCD60_HUMAN 82.299 0.992701 0.996364 CCDC60 - Coiled-coil domain-containing protein 60 - Homo sapiens (Human) - CCDC60 gene Taurus_UMD|evm.model.AC_000174.1.381 Q5EAC9 HSPB8_BOVIN 100.000 0.989848 1.0051 HSPB8 - Heat shock protein beta-8 - Bos taurus (Bovine) - HSPB8 gene Displays temperature-dependent chaperone activity. Taurus_UMD|evm.model.AC_000174.1.382 A7MD48 SRRM4_HUMAN 89.562 0.786184 0.99509 SRRM4 - Serine/arginine repetitive matrix protein 4 - Homo sapiens (Human) - SRRM4 gene Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity). Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells (PubMed:30684677). Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions (By similarity). Taurus_UMD|evm.model.AC_000174.1.383 A6H6W9 SDS3_BOVIN 98.476 0.98494 1.0122 SUDS3 - Sin3 histone deacetylase corepressor complex component SDS3 - Bos taurus (Bovine) - SUDS3 gene Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). Taurus_UMD|evm.model.AC_000174.1.384 Q9H2K8 TAOK3_HUMAN 97.884 0.997775 1.00111 TAOK3 - Serine/threonine-protein kinase TAO3 - Homo sapiens (Human) - TAOK3 gene Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). Taurus_UMD|evm.model.AC_000174.1.385 P13696 PEBP1_BOVIN 100.000 0.989362 1.00535 PEBP1 - Phosphatidylethanolamine-binding protein 1 - Bos taurus (Bovine) - PEBP1 gene Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). Taurus_UMD|evm.model.AC_000174.1.386 Q8N0Z9 VSI10_HUMAN 77.306 0.996296 1 VSIG10 - V-set and immunoglobulin domain-containing protein 10 precursor - Homo sapiens (Human) - VSIG10 gene cell-cell junction, integral component of plasma membrane, cell adhesion molecule binding, cell-cell adhesion Taurus_UMD|evm.model.AC_000174.1.387 Q0V8J1 WSB2_BOVIN 100.000 0.995086 1.00246 WSB2 - WD repeat and SOCS box-containing protein 2 - Bos taurus (Bovine) - WSB2 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000174.1.388 P40937 RFC5_HUMAN 90.358 0.99449 1.06765 RFC5 - Replication factor C subunit 5 - Homo sapiens (Human) - RFC5 gene The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Taurus_UMD|evm.model.AC_000174.1.390 Q6VAB6 KSR2_HUMAN 91.304 0.299559 0.238947 KSR2 - Kinase suppressor of Ras 2 - Homo sapiens (Human) - KSR2 gene Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Taurus_UMD|evm.model.AC_000174.1.391 Q6VAB6 KSR2_HUMAN 97.959 0.617834 0.165263 KSR2 - Kinase suppressor of Ras 2 - Homo sapiens (Human) - KSR2 gene Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Taurus_UMD|evm.model.AC_000174.1.392 Q6VAB6 KSR2_HUMAN 96.552 0.977401 0.186316 KSR2 - Kinase suppressor of Ras 2 - Homo sapiens (Human) - KSR2 gene Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Taurus_UMD|evm.model.AC_000174.1.393 Q3UVC0 KSR2_MOUSE 91.803 0.342857 0.182482 Ksr2 - Kinase suppressor of Ras 2 - Mus musculus (Mouse) - Ksr2 gene Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1. Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Taurus_UMD|evm.model.AC_000174.1.394 Q6VAB6 KSR2_HUMAN 100.000 0.150519 0.608421 KSR2 - Kinase suppressor of Ras 2 - Homo sapiens (Human) - KSR2 gene Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Taurus_UMD|evm.model.AC_000174.1.395 P29475 NOS1_HUMAN 89.262 0.996241 0.927476 NOS1 - Nitric oxide synthase, brain - Homo sapiens (Human) - NOS1 gene Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Taurus_UMD|evm.model.AC_000174.1.396 P0DL28 FBXW8_RAT 72.028 0.821326 0.582215 Fbxw8 - F-box/WD repeat-containing protein 8 - Rattus norvegicus (Rat) - Fbxw8 gene Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity). The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Taurus_UMD|evm.model.AC_000174.1.397 P29475 NOS1_HUMAN 93.478 0.505618 0.0620642 NOS1 - Nitric oxide synthase, brain - Homo sapiens (Human) - NOS1 gene Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Taurus_UMD|evm.model.AC_000174.1.398 O94952 FBX21_HUMAN 98.246 0.996815 1 FBXO21 - F-box only protein 21 - Homo sapiens (Human) - FBXO21 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000174.1.399 Q96BS2 CHP3_HUMAN 97.196 0.990698 1.00467 TESC - Calcineurin B homologous protein 3 - Homo sapiens (Human) - TESC gene Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. Taurus_UMD|evm.model.AC_000174.1.400 Q8N3Y1 FBXW8_HUMAN 79.167 0.910326 0.615385 FBXW8 - F-box/WD repeat-containing protein 8 - Homo sapiens (Human) - FBXW8 gene Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). Taurus_UMD|evm.model.AC_000174.1.401 O00198 HRK_HUMAN 98.901 0.978261 1.01099 HRK - Activator of apoptosis harakiri - Homo sapiens (Human) - HRK gene Promotes apoptosis. Taurus_UMD|evm.model.AC_000174.1.402 Q96EX2 RNFT2_HUMAN 93.987 0.995556 1.01351 RNFT2 - RING finger and transmembrane domain-containing protein 2 - Homo sapiens (Human) - RNFT2 gene ubiquitin protein ligase activity Taurus_UMD|evm.model.AC_000174.1.403 Q17QN8 SPRNG_BOVIN 100.000 0.990291 1.00488 SPRING - SREBP regulating gene protein - Bos taurus (Bovine) - SPRING gene Positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP. Taurus_UMD|evm.model.AC_000174.1.406 Q71F56 MD13L_HUMAN 96.296 0.969374 1.01946 MED13L - Mediator of RNA polymerase II transcription subunit 13-like - Homo sapiens (Human) - MED13L gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. Taurus_UMD|evm.model.AC_000174.1.410 O15119 TBX3_HUMAN 95.623 0.948636 0.838493 TBX3 - T-box transcription factor TBX3 - Homo sapiens (Human) - TBX3 gene Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. Taurus_UMD|evm.model.AC_000174.1.412 Q99593 TBX5_HUMAN 97.495 0.996154 1.00386 TBX5 - T-box transcription factor TBX5 - Homo sapiens (Human) - TBX5 gene DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation (PubMed:25725155, PubMed:25963046, PubMed:29174768, PubMed:26917986, PubMed:27035640, PubMed:8988164). Binds to the core DNA motif of NPPA promoter (PubMed:26926761). Taurus_UMD|evm.model.AC_000174.1.413 Q9Y4C8 RBM19_HUMAN 85.593 0.12759 0.955208 RBM19 - Probable RNA-binding protein 19 - Homo sapiens (Human) - RBM19 gene Plays a role in embryo pre-implantation development. Taurus_UMD|evm.model.AC_000174.1.415 Q9H2C1 LHX5_HUMAN 99.005 0.995037 1.00249 LHX5 - LIM/homeobox protein Lhx5 - Homo sapiens (Human) - LHX5 gene Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system. Taurus_UMD|evm.model.AC_000174.1.416 Q96GA7 SDSL_HUMAN 83.232 0.886179 1.12158 SDSL - Serine dehydratase-like - Homo sapiens (Human) - SDSL gene Has low serine dehydratase and threonine dehydratase activity. Taurus_UMD|evm.model.AC_000174.1.417 Q0VCW4 SDHL_BOVIN 99.694 0.993902 1.00306 SDS - L-serine dehydratase/L-threonine deaminase - Bos taurus (Bovine) - SDS gene L-serine ammonia-lyase activity, L-threonine ammonia-lyase activity, protein homodimerization activity, pyridoxal phosphate binding, isoleucine biosynthetic process, L-serine catabolic process, pyruvate biosynthetic process, threonine catabolic process Taurus_UMD|evm.model.AC_000174.1.418 Q2KIY5 PLBL2_BOVIN 99.830 0.99661 1.0017 PLBD2 - Putative phospholipase B-like 2 precursor - Bos taurus (Bovine) - PLBD2 gene Putative phospholipase. Taurus_UMD|evm.model.AC_000174.1.419 Q86Y01 DTX1_HUMAN 97.581 0.996774 1 DTX1 - E3 ubiquitin-protein ligase DTX1 - Homo sapiens (Human) - DTX1 gene Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. Taurus_UMD|evm.model.AC_000174.1.420 O95294 RASL1_HUMAN 87.946 0.968974 1.04229 RASAL1 - RasGAP-activating-like protein 1 - Homo sapiens (Human) - RASAL1 gene Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Taurus_UMD|evm.model.AC_000174.1.421 A6NFT4 CFA73_HUMAN 79.931 0.947368 0.987013 CFAP73 - Cilia- and flagella-associated protein 73 - Homo sapiens (Human) - CFAP73 gene May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm. Taurus_UMD|evm.model.AC_000174.1.422 Q8TDD1 DDX54_HUMAN 89.557 0.997719 0.99546 DDX54 - ATP-dependent RNA helicase DDX54 - Homo sapiens (Human) - DDX54 gene Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. Taurus_UMD|evm.model.AC_000174.1.423 Q2HJ75 RITA1_BOVIN 100.000 0.911565 1.09294 RITA1 - RBPJ-interacting and tubulin-associated protein 1 - Bos taurus (Bovine) - RITA1 gene Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity). Taurus_UMD|evm.model.AC_000174.1.424 Q17QH9 DRC10_BOVIN 100.000 0.995506 1.00225 IQCD - Dynein regulatory complex protein 10 - Bos taurus (Bovine) - IQCD gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Taurus_UMD|evm.model.AC_000174.1.425 Q9ULQ1 TPC1_HUMAN 91.922 0.93786 1.06495 TPCN1 - Two pore calcium channel protein 1 - Homo sapiens (Human) - TPCN1 gene Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. Taurus_UMD|evm.model.AC_000174.1.426 Q6J4K2 NCLX_HUMAN 79.299 0.99682 1.07705 SLC8B1 - Mitochondrial sodium/calcium exchanger protein precursor - Homo sapiens (Human) - SLC8B1 gene Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K(+) (PubMed:15060069). Taurus_UMD|evm.model.AC_000174.1.428 F1N3B8 OAS2_BOVIN 95.646 0.997195 0.998599 OAS2 - 2'-5'-oligoadenylate synthase 2 - Bos taurus (Bovine) - OAS2 gene Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (By similarity). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity). Taurus_UMD|evm.model.AC_000174.1.429 P00973 OAS1_HUMAN 75.847 0.235471 2.495 OAS1 - 2'-5'-oligoadenylate synthase 1 - Homo sapiens (Human) - OAS1 gene Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. Taurus_UMD|evm.model.AC_000174.1.430 Q06846 RP3A_BOVIN 99.006 0.997147 0.995739 RPH3A - Rabphilin-3A - Bos taurus (Bovine) - RPH3A gene Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (PubMed:9450942). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone (By similarity). Taurus_UMD|evm.model.AC_000174.1.431 Q06124 PTN11_HUMAN 98.988 0.996633 1.00169 PTPN11 - Tyrosine-protein phosphatase non-receptor type 11 - Homo sapiens (Human) - PTPN11 gene Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Taurus_UMD|evm.model.AC_000174.1.432 Q58DQ3 RL6_BOVIN 100.000 0.993056 1.00348 RPL6 - 60S ribosomal protein L6 - Bos taurus (Bovine) - RPL6 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000174.1.433 Q9Y4D8 HECD4_HUMAN 97.149 0.910387 1.10586 HECTD4 - Probable E3 ubiquitin-protein ligase HECTD4 - Homo sapiens (Human) - HECTD4 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Taurus_UMD|evm.model.AC_000174.1.434 Q58D05 TRAD1_BOVIN 98.383 0.695489 0.917241 TRAFD1 - TRAF-type zinc finger domain-containing protein 1 - Bos taurus (Bovine) - TRAFD1 gene Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). Taurus_UMD|evm.model.AC_000174.1.435 P56747 CLD6_HUMAN 71.186 0.95082 0.277273 CLDN6 - Claudin-6 - Homo sapiens (Human) - CLDN6 gene Plays a major role in tight junction-specific obliteration of the intercellular space. Taurus_UMD|evm.model.AC_000174.1.436 Q14CX7 NAA25_HUMAN 96.552 0.938114 1.04733 NAA25 - N-alpha-acetyltransferase 25, NatB auxiliary subunit - Homo sapiens (Human) - NAA25 gene Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression. Taurus_UMD|evm.model.AC_000174.1.437 P81623 ERP29_BOVIN 100.000 0.992278 1.00388 ERP29 - Endoplasmic reticulum resident protein 29 precursor - Bos taurus (Bovine) - ERP29 gene Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the ER (By similarity). Taurus_UMD|evm.model.AC_000174.1.438 Q8NCL8 TM116_HUMAN 81.557 0.612091 1.62041 TMEM116 - Transmembrane protein 116 - Homo sapiens (Human) - TMEM116 gene Taurus_UMD|evm.model.AC_000174.1.439 P24049 RL17_RAT 90.698 0.984615 0.706522 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000174.1.440 Q60813 ADM1A_MOUSE 61.062 0.86352 0.99115 Adam1a - Disintegrin and metalloproteinase domain-containing protein 1a precursor - Mus musculus (Mouse) - Adam1a gene May be involved in sperm-egg fusion. Taurus_UMD|evm.model.AC_000174.1.441 Q60813 ADM1A_MOUSE 61.644 0.795829 1.15171 Adam1a - Disintegrin and metalloproteinase domain-containing protein 1a precursor - Mus musculus (Mouse) - Adam1a gene May be involved in sperm-egg fusion. Taurus_UMD|evm.model.AC_000174.1.442 Q8IW41 MAPK5_HUMAN 97.447 0.991507 0.995772 MAPKAPK5 - MAP kinase-activated protein kinase 5 - Homo sapiens (Human) - MAPKAPK5 gene Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. Taurus_UMD|evm.model.AC_000174.1.443 P20000 ALDH2_BOVIN 100.000 0.996161 1.00192 ALDH2 - Aldehyde dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ALDH2 gene aldehyde dehydrogenase (NAD+) activity, NAD binding Taurus_UMD|evm.model.AC_000174.1.445 Q6ZP65 BICL1_HUMAN 86.356 0.996678 1.05061 BICDL1 - BICD family-like cargo adapter 1 - Homo sapiens (Human) - BICDL1 gene Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis (By similarity). Taurus_UMD|evm.model.AC_000174.1.446 Q5U316 RAB35_RAT 99.502 0.990099 1.00498 Rab35 - Ras-related protein Rab-35 - Rattus norvegicus (Rat) - Rab35 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes (By similarity). Taurus_UMD|evm.model.AC_000174.1.447 Q92616 GCN1_HUMAN 96.106 0.999251 1.00037 GCN1 - eIF-2-alpha kinase activator GCN1 - Homo sapiens (Human) - GCN1 gene Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Taurus_UMD|evm.model.AC_000174.1.448 Q95140 RLA0_BOVIN 100.000 0.99373 1.00314 RPLP0 - 60S acidic ribosomal protein P0 - Bos taurus (Bovine) - RPLP0 gene Ribosomal protein P0 is the functional equivalent of E.coli protein L10. Taurus_UMD|evm.model.AC_000174.1.449 Q66H76 PAXI_RAT 97.500 0.260504 1.82765 Pxn - Paxillin - Rattus norvegicus (Rat) - Pxn gene Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Taurus_UMD|evm.model.AC_000174.1.450 Q1JQC6 SIR4_BOVIN 100.000 0.756627 1.31746 SIRT4 - NAD-dependent protein lipoamidase sirtuin-4, mitochondrial precursor - Bos taurus (Bovine) - SIRT4 gene Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion (By similarity). Taurus_UMD|evm.model.AC_000174.1.451 O43347 MSI1H_HUMAN 100.000 0.886486 1.0221 MSI1 - RNA-binding protein Musashi homolog 1 - Homo sapiens (Human) - MSI1 gene RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). Taurus_UMD|evm.model.AC_000174.1.452 P13182 CX6A1_BOVIN 100.000 0.603352 1.6422 COX6A1 - Cytochrome c oxidase subunit 6A1, mitochondrial precursor - Bos taurus (Bovine) - COX6A1 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000174.1.453 Q9D8Z2 TRIA1_MOUSE 98.684 0.824176 1.19737 Triap1 - TP53-regulated inhibitor of apoptosis 1 - Mus musculus (Mouse) - Triap1 gene Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. Taurus_UMD|evm.model.AC_000174.1.454 Q2KIF1 GATC_BOVIN 100.000 0.985401 1.00735 GATC - Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial precursor - Bos taurus (Bovine) - GATC gene Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Taurus_UMD|evm.model.AC_000174.1.455 Q9D0B0 SRSF9_MOUSE 98.182 0.986486 1 Srsf9 - Serine/arginine-rich splicing factor 9 - Mus musculus (Mouse) - Srsf9 gene Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10 (By similarity). Taurus_UMD|evm.model.AC_000174.1.456 P63170 DYL1_RAT 100.000 0.977778 1.01124 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Taurus_UMD|evm.model.AC_000174.1.457 Q0P5A2 COQ5_BOVIN 100.000 0.950867 1.04848 COQ5 - 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor - Bos taurus (Bovine) - COQ5 gene Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). Taurus_UMD|evm.model.AC_000174.1.458 Q08E13 RNF10_BOVIN 100.000 0.997534 1.00123 RNF10 - RING finger protein 10 - Bos taurus (Bovine) - RNF10 gene Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination. Taurus_UMD|evm.model.AC_000174.1.459 Q1JQ92 POP5_BOVIN 99.412 0.988304 1.00588 POP5 - Ribonuclease P/MRP protein subunit POP5 - Bos taurus (Bovine) - POP5 gene Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Taurus_UMD|evm.model.AC_000174.1.460 Q9NZU7 CABP1_HUMAN 100.000 0.583012 0.7 CABP1 - Calcium-binding protein 1 - Homo sapiens (Human) - CABP1 gene Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs)(PubMed:14570872). Inhibits agonist-induced intracellular calcium signaling (PubMed:15980432). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed:15895247). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity). Taurus_UMD|evm.model.AC_000174.1.461 Q14165 MLEC_HUMAN 94.178 0.992958 0.972603 MLEC - Malectin precursor - Homo sapiens (Human) - MLEC gene Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity). Taurus_UMD|evm.model.AC_000174.1.462 A6NIH7 U119B_HUMAN 92.520 0.992157 1.01594 UNC119B - Protein unc-119 homolog B - Homo sapiens (Human) - UNC119B gene Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells. Taurus_UMD|evm.model.AC_000174.1.463 Q3ZBF6 ACADS_BOVIN 98.544 0.995122 0.995146 ACADS - Short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ACADS gene Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:6712627). Taurus_UMD|evm.model.AC_000174.1.464 Q9CUS9 SPPL3_MOUSE 99.740 0.994805 1.0026 Sppl3 - Signal peptide peptidase-like 3 - Mus musculus (Mouse) - Sppl3 gene Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries. Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971). Taurus_UMD|evm.model.AC_000174.1.465 P20823 HNF1A_HUMAN 95.419 0.996845 1.00475 HNF1A - Hepatocyte nuclear factor 1-alpha - Homo sapiens (Human) - HNF1A gene Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:12453420, PubMed:10966642). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). Taurus_UMD|evm.model.AC_000174.1.466 Q58CQ0 CSTOS_BOVIN 98.444 0.992248 1.00389 CUSTOS - Protein CUSTOS - Bos taurus (Bovine) - CUSTOS gene Plays a role in the regulation of Wnt signaling pathway during early development. Taurus_UMD|evm.model.AC_000174.1.467 Q15646 OASL_HUMAN 59.557 0.995798 0.92607 OASL - 2'-5'-oligoadenylate synthase-like protein - Homo sapiens (Human) - OASL gene Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. Taurus_UMD|evm.model.AC_000174.1.468 Q3SYA9 P12L1_HUMAN 48.182 0.157895 1.59813 POM121L1P - Putative POM121-like protein 1 - Homo sapiens (Human) - POM121L1P gene Taurus_UMD|evm.model.AC_000174.1.470 Q8IZ07 AN13A_HUMAN 93.559 0.996616 1.00169 ANKRD13A - Ankyrin repeat domain-containing protein 13A - Homo sapiens (Human) - ANKRD13A gene Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. Taurus_UMD|evm.model.AC_000174.1.471 Q14161 GIT2_HUMAN 95.916 0.997368 1.00132 GIT2 - ARF GTPase-activating protein GIT2 - Homo sapiens (Human) - GIT2 gene GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Taurus_UMD|evm.model.AC_000174.1.473 Q5RE49 TCHP_PONAB 84.800 0.996008 1.00602 TCHP - Trichoplein keratin filament-binding protein - Pongo abelii (Sumatran orangutan) - TCHP gene Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Taurus_UMD|evm.model.AC_000174.1.474 P68266 GLTP_PIG 99.522 0.990476 1.00478 GLTP - Glycolipid transfer protein - Sus scrofa (Pig) - GLTP gene Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides (By similarity). Taurus_UMD|evm.model.AC_000174.1.475 Q9HBA0 TRPV4_HUMAN 96.785 0.997706 1.00115 TRPV4 - Transient receptor potential cation channel subfamily V member 4 - Homo sapiens (Human) - TRPV4 gene Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040, PubMed:29899501). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed:29899501). Taurus_UMD|evm.model.AC_000174.1.476 Q5U5X8 F222A_HUMAN 85.449 0.894444 0.79646 FAM222A - Protein FAM222A - Homo sapiens (Human) - FAM222A gene Taurus_UMD|evm.model.AC_000174.1.478 Q5U5X8 F222A_HUMAN 96.552 0.373333 0.165929 FAM222A - Protein FAM222A - Homo sapiens (Human) - FAM222A gene Taurus_UMD|evm.model.AC_000174.1.480 Q5E9T8 KIME_BOVIN 100.000 0.994962 1.00253 MVK - Mevalonate kinase - Bos taurus (Bovine) - MVK gene Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis. Taurus_UMD|evm.model.AC_000174.1.481 Q58D49 MMAB_BOVIN 87.149 0.99187 1.02075 MMAB - Corrinoid adenosyltransferase precursor - Bos taurus (Bovine) - MMAB gene Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA. Taurus_UMD|evm.model.AC_000174.1.482 Q7Z3V4 UBE3B_HUMAN 95.599 0.987049 1.01217 UBE3B - Ubiquitin-protein ligase E3B - Homo sapiens (Human) - UBE3B gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Taurus_UMD|evm.model.AC_000174.1.483 Q9H3F6 BACD3_HUMAN 99.051 0.993691 1.01278 KCTD10 - BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 - Homo sapiens (Human) - KCTD10 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity). Taurus_UMD|evm.model.AC_000174.1.484 Q8N1T3 MYO1H_HUMAN 89.808 0.966469 0.982558 MYO1H - Unconventional myosin-Ih - Homo sapiens (Human) - MYO1H gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Taurus_UMD|evm.model.AC_000174.1.485 Q96NZ1 FOXN4_HUMAN 90.154 0.959184 1.04255 FOXN4 - Forkhead box protein N4 - Homo sapiens (Human) - FOXN4 gene Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity). Taurus_UMD|evm.model.AC_000174.1.486 O00763 ACACB_HUMAN 89.741 0.985488 0.925142 ACACB - Acetyl-CoA carboxylase 2 precursor - Homo sapiens (Human) - ACACB gene Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:19900410, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity). Taurus_UMD|evm.model.AC_000174.1.487 O00763 ACACB_HUMAN 60.622 0.989583 0.0781123 ACACB - Acetyl-CoA carboxylase 2 precursor - Homo sapiens (Human) - ACACB gene Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:19900410, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity). Taurus_UMD|evm.model.AC_000174.1.488 P13051 UNG_HUMAN 91.401 0.993631 1.00319 UNG - Uracil-DNA glycosylase - Homo sapiens (Human) - UNG gene Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Taurus_UMD|evm.model.AC_000174.1.489 Q58DM4 ALKB2_BOVIN 99.640 0.992832 1.0036 ALKBH2 - DNA oxidative demethylase ALKBH2 - Bos taurus (Bovine) - ALKBH2 gene Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). Taurus_UMD|evm.model.AC_000174.1.490 Q70CQ3 UBP30_HUMAN 91.489 0.996139 1.00193 USP30 - Ubiquitin carboxyl-terminal hydrolase 30 - Homo sapiens (Human) - USP30 gene Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). Taurus_UMD|evm.model.AC_000174.1.491 Q1JP63 SVOP_BOVIN 100.000 0.996357 1.00182 SVOP - Synaptic vesicle 2-related protein - Bos taurus (Bovine) - SVOP gene Taurus_UMD|evm.model.AC_000174.1.492 P00371 OXDA_PIG 89.914 0.994253 1.00288 DAO - D-amino-acid oxidase - Sus scrofa (Pig) - DAO gene Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. Taurus_UMD|evm.model.AC_000174.1.493 Q8WYL5 SSH1_HUMAN 81.660 0.988235 0.972355 SSH1 - Protein phosphatase Slingshot homolog 1 - Homo sapiens (Human) - SSH1 gene Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. Taurus_UMD|evm.model.AC_000174.1.494 Q9ULV4 COR1C_HUMAN 98.734 0.925636 1.07806 CORO1C - Coronin-1C - Homo sapiens (Human) - CORO1C gene Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). Taurus_UMD|evm.model.AC_000174.1.495 Q14242 SELPL_HUMAN 44.780 0.96729 1.03883 SELPLG - P-selectin glycoprotein ligand 1 precursor - Homo sapiens (Human) - SELPLG gene A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. Taurus_UMD|evm.model.AC_000174.1.496 Q4V9L6 TM119_HUMAN 73.702 0.993056 1.01767 TMEM119 - Transmembrane protein 119 precursor - Homo sapiens (Human) - TMEM119 gene Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). Taurus_UMD|evm.model.AC_000174.1.497 Q15020 SART3_HUMAN 84.866 0.962319 0.716511 SART3 - Squamous cell carcinoma antigen recognized by T-cells 3 - Homo sapiens (Human) - SART3 gene U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity). Taurus_UMD|evm.model.AC_000174.1.498 Q9BVA6 FICD_HUMAN 90.830 0.851024 1.17249 FICD - Protein adenylyltransferase FICD - Homo sapiens (Human) - FICD gene Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (PubMed:19362538, PubMed:25601083). Taurus_UMD|evm.model.AC_000174.1.499 Q5REG1 SART3_PONAB 87.819 0.437656 0.817533 SART3 - Squamous cell carcinoma antigen recognized by T-cells 3 - Pongo abelii (Sumatran orangutan) - SART3 gene U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly. May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair. May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC. Taurus_UMD|evm.model.AC_000174.1.500 Q9H1K1 ISCU_HUMAN 97.605 0.988095 1.00599 ISCU - Iron-sulfur cluster assembly enzyme ISCU, mitochondrial precursor - Homo sapiens (Human) - ISCU gene Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed:11060020). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity). Taurus_UMD|evm.model.AC_000174.1.501 B9VR26 CML1_BOVIN 100.000 0.99449 1.00276 CMLKR1 - Chemokine-like receptor 1 - Bos taurus (Bovine) - CMLKR1 gene Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity). Taurus_UMD|evm.model.AC_000174.1.502 Q2TBF2 WSCD2_HUMAN 94.867 0.99646 1 WSCD2 - WSC domain-containing protein 2 - Homo sapiens (Human) - WSCD2 gene Taurus_UMD|evm.model.AC_000174.1.504 Q3SYA9 P12L1_HUMAN 45.492 0.542601 1.04206 POM121L1P - Putative POM121-like protein 1 - Homo sapiens (Human) - POM121L1P gene Taurus_UMD|evm.model.AC_000174.1.505 Q7Z3Z3 PIWL3_HUMAN 52.262 0.978628 1.00794 PIWIL3 - Piwi-like protein 3 - Homo sapiens (Human) - PIWIL3 gene May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Taurus_UMD|evm.model.AC_000174.1.506 Q8BPQ7 SGSM1_MOUSE 93.510 0.91541 1.09241 Sgsm1 - Small G protein signaling modulator 1 - Mus musculus (Mouse) - Sgsm1 gene Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B. Taurus_UMD|evm.model.AC_000174.1.507 Q6ICI0 TM211_HUMAN 77.500 0.99005 1.005 TMEM211 - Transmembrane protein 211 - Homo sapiens (Human) - TMEM211 gene membrane Taurus_UMD|evm.model.AC_000174.1.508 Q8BRV5 K1671_MOUSE 74.497 0.163798 5.8474 Kiaa1671 - Uncharacterized protein KIAA1671 - Mus musculus (Mouse) - Kiaa1671 gene Taurus_UMD|evm.model.AC_000174.1.509 P19141 CRBB3_BOVIN 100.000 0.990566 1.00474 CRYBB3 - Beta-crystallin B3 - Bos taurus (Bovine) - CRYBB3 gene Crystallins are the dominant structural components of the vertebrate eye lens. Taurus_UMD|evm.model.AC_000174.1.510 P02522 CRBB2_BOVIN 100.000 0.990291 1.00488 CRYBB2 - Beta-crystallin B2 - Bos taurus (Bovine) - CRYBB2 gene Crystallins are the dominant structural components of the vertebrate eye lens. Taurus_UMD|evm.model.AC_000174.1.511 P26818 ARBK2_BOVIN 100.000 0.996909 0.940407 GRK3 - Beta-adrenergic receptor kinase 2 - Bos taurus (Bovine) - GRK3 gene Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Taurus_UMD|evm.model.AC_000174.1.512 Q8IUG5 MY18B_HUMAN 66.784 0.983258 0.954032 MYO18B - Unconventional myosin-XVIIIb - Homo sapiens (Human) - MYO18B gene May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. Taurus_UMD|evm.model.AC_000174.1.513 Q9BYH1 SE6L1_HUMAN 85.895 0.899299 1.11523 SEZ6L - Seizure 6-like protein precursor - Homo sapiens (Human) - SEZ6L gene May contribute to specialized endoplasmic reticulum functions in neurons. Taurus_UMD|evm.model.AC_000174.1.514 Q6ICH7 ASPH2_HUMAN 91.837 0.994186 0.932249 ASPHD2 - Aspartate beta-hydroxylase domain-containing protein 2 - Homo sapiens (Human) - ASPHD2 gene May function as 2-oxoglutarate-dependent dioxygenase. Taurus_UMD|evm.model.AC_000174.1.515 Q9NQG7 HPS4_HUMAN 65.541 0.997067 0.963277 HPS4 - Hermansky-Pudlak syndrome 4 protein - Homo sapiens (Human) - HPS4 gene Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991). Taurus_UMD|evm.model.AC_000174.1.516 Q9UH36 SRR1L_HUMAN 68.790 0.925373 0.988201 SRRD - SRR1-like protein - Homo sapiens (Human) - SRRD gene Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes. Taurus_UMD|evm.model.AC_000174.1.517 Q29RR5 TFP11_BOVIN 99.761 0.997613 1.00119 TFIP11 - Tuftelin-interacting protein 11 - Bos taurus (Bovine) - TFIP11 gene Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity). Taurus_UMD|evm.model.AC_000174.1.518 Q3SYY2 TPST2_BOVIN 90.049 0.89738 1.21485 TPST2 - Protein-tyrosine sulfotransferase 2 - Bos taurus (Bovine) - TPST2 gene Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. Taurus_UMD|evm.model.AC_000174.1.520 P07318 CRBB1_BOVIN 99.482 0.872727 0.869565 CRYBB1 - Beta-crystallin B1 - Bos taurus (Bovine) - CRYBB1 gene Crystallins are the dominant structural components of the vertebrate eye lens. Taurus_UMD|evm.model.AC_000174.1.521 P11842 CRBA4_BOVIN 100.000 0.989848 0.938095 CRYBA4 - Beta-crystallin A4 - Bos taurus (Bovine) - CRYBA4 gene Crystallins are the dominant structural components of the vertebrate eye lens. Taurus_UMD|evm.model.AC_000174.1.524 Q4FZT6 H2A3_RAT 98.462 0.984733 1.00769 Histone H2A type 3 - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000174.1.527 Q10571 MN1_HUMAN 91.341 0.32185 0.835606 MN1 - Transcriptional activator MN1 - Homo sapiens (Human) - MN1 gene Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). Taurus_UMD|evm.model.AC_000174.1.528 Q9TR36 PIPNB_BOVIN 100.000 0.992647 1.00369 PITPNB - Phosphatidylinositol transfer protein beta isoform - Bos taurus (Bovine) - PITPNB gene Catalyzes the transfer of phosphatidylinositol, phosphatidylcholine and sphingomyelin between membranes (PubMed:7654206). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (By similarity). Taurus_UMD|evm.model.AC_000174.1.529 Q3V3Q4 PYDC3_MOUSE 33.735 0.719298 0.193878 Pydc3 - Pyrin domain-containing protein 3 - Mus musculus (Mouse) - Pydc3 gene cytosol, nucleolus, nucleoplasm, nucleus, DNA-binding transcription repressor activity, RNA polymerase II-specific, double-stranded DNA binding, identical protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, transcription factor binding, cellular response to interferon-beta Taurus_UMD|evm.model.AC_000174.1.530 Q96AY4 TTC28_HUMAN 93.911 0.9983 0.948408 TTC28 - Tetratricopeptide repeat protein 28 - Homo sapiens (Human) - TTC28 gene During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. Taurus_UMD|evm.model.AC_000174.1.531 Q9Z265 CHK2_MOUSE 84.000 0.77044 1.16484 Chek2 - Serine/threonine-protein kinase Chk2 - Mus musculus (Mouse) - Chek2 gene Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (By similarity). Taurus_UMD|evm.model.AC_000174.1.532 Q8IWL3 HSC20_HUMAN 84.681 0.991525 1.00426 HSCB - Iron-sulfur cluster co-chaperone protein HscB - Homo sapiens (Human) - HSCB gene Acts as a co-chaperone in iron-sulfur cluster assembly in both mitochondria and the cytoplasm (PubMed:20668094, PubMed:29309586). Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain (PubMed:26749241). Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 (PubMed:26749241). Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1 (PubMed:29309586). This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT (PubMed:29309586). Taurus_UMD|evm.model.AC_000174.1.533 Q8IWD4 CC117_HUMAN 88.530 0.992832 1 CCDC117 - Coiled-coil domain-containing protein 117 - Homo sapiens (Human) - CCDC117 gene Taurus_UMD|evm.model.AC_000174.1.534 Q3SZZ2 XBP1_BOVIN 100.000 0.446809 1.44061 XBP1 - X-box-binding protein 1 - Bos taurus (Bovine) - XBP1 gene Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland. Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes. Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention. Taurus_UMD|evm.model.AC_000174.1.536 Q9ULT6 ZNRF3_HUMAN 99.170 0.312907 0.819444 ZNRF3 - E3 ubiquitin-protein ligase ZNRF3 precursor - Homo sapiens (Human) - ZNRF3 gene E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity). Taurus_UMD|evm.model.AC_000174.1.537 O95567 CV031_HUMAN 73.684 0.937086 1.04138 C22orf31 - Uncharacterized protein C22orf31 - Homo sapiens (Human) - C22orf31 gene Taurus_UMD|evm.model.AC_000174.1.538 Q96MU8 KREM1_HUMAN 88.036 0.798872 1.12474 KREMEN1 - Kremen protein 1 precursor - Homo sapiens (Human) - KREMEN1 gene Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification. Taurus_UMD|evm.model.AC_000174.1.539 Q96A84 EMID1_HUMAN 76.134 0.994094 1.15193 EMID1 - EMI domain-containing protein 1 precursor - Homo sapiens (Human) - EMID1 gene Taurus_UMD|evm.model.AC_000174.1.540 Q9Y3P4 RHBD3_HUMAN 82.902 0.912322 1.09326 RHBDD3 - Rhomboid domain-containing protein 3 - Homo sapiens (Human) - RHBDD3 gene serine-type endopeptidase activity Taurus_UMD|evm.model.AC_000174.1.541 Q01844 EWS_HUMAN 98.628 0.996951 1 EWSR1 - RNA-binding protein EWS - Homo sapiens (Human) - EWSR1 gene Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. Taurus_UMD|evm.model.AC_000174.1.542 Q99501 GA2L1_HUMAN 89.736 0.997059 0.998532 GAS2L1 - GAS2-like protein 1 - Homo sapiens (Human) - GAS2L1 gene Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). Taurus_UMD|evm.model.AC_000174.1.543 Q92737 RSLAA_HUMAN 98.030 0.990196 1.00493 RASL10A - Ras-like protein family member 10A precursor - Homo sapiens (Human) - RASL10A gene Potent inhibitor of cellular proliferation. Taurus_UMD|evm.model.AC_000174.1.544 Q10567 AP1B1_HUMAN 96.207 0.997872 0.990516 AP1B1 - AP-1 complex subunit beta-1 - Homo sapiens (Human) - AP1B1 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed:31630791). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Taurus_UMD|evm.model.AC_000174.1.546 P12036 NFH_HUMAN 79.385 0.996255 1.04094 NEFH - Neurofilament heavy polypeptide - Homo sapiens (Human) - NEFH gene Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). Taurus_UMD|evm.model.AC_000174.1.547 A4IFQ0 THOC5_BOVIN 99.854 0.997076 1.00146 THOC5 - THO complex subunit 5 homolog - Bos taurus (Bovine) - THOC5 gene Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes (By similarity). Taurus_UMD|evm.model.AC_000174.1.548 Q9BPW8 NIPS1_HUMAN 91.126 0.993197 1.03521 NIPSNAP1 - Protein NipSnap homolog 1 - Homo sapiens (Human) - NIPSNAP1 gene mitochondrion, sensory perception of pain Taurus_UMD|evm.model.AC_000174.1.549 P59750 MERL_PAPAN 98.154 0.99665 1.00336 NF2 - Merlin - Papio anubis (Olive baboon) - NF2 gene Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity). Taurus_UMD|evm.model.AC_000174.1.551 Q66H96 CABP7_RAT 100.000 0.987097 0.72093 Cabp7 - Calcium-binding protein 7 - Rattus norvegicus (Rat) - Cabp7 gene Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. Taurus_UMD|evm.model.AC_000174.1.552 Q2TA39 ZMAT5_BOVIN 100.000 0.710084 1.4 ZMAT5 - Zinc finger matrin-type protein 5 - Bos taurus (Bovine) - ZMAT5 gene U12-type spliceosomal complex Taurus_UMD|evm.model.AC_000174.1.553 P00130 QCR9_BOVIN 100.000 0.969231 1.01562 UQCR10 - Cytochrome b-c1 complex subunit 9 - Bos taurus (Bovine) - UQCR10 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Taurus_UMD|evm.model.AC_000174.1.554 Q9H1I8 ASCC2_HUMAN 87.186 0.894484 1.10172 ASCC2 - Activating signal cointegrator 1 complex subunit 2 - Homo sapiens (Human) - ASCC2 gene Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Taurus_UMD|evm.model.AC_000174.1.555 Q13615 MTMR3_HUMAN 89.268 0.998324 0.995826 MTMR3 - Myotubularin-related protein 3 - Homo sapiens (Human) - MTMR3 gene Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:11676921). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11676921). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931). Taurus_UMD|evm.model.AC_000174.1.556 A6QQY4 HORM2_BOVIN 99.673 0.993485 1.00327 HORMAD2 - HORMA domain-containing protein 2 - Bos taurus (Bovine) - HORMAD2 gene Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity). Taurus_UMD|evm.model.AC_000174.1.557 Q27956 LIF_BOVIN 99.497 0.965854 1.01485 LIF - Leukemia inhibitory factor precursor - Bos taurus (Bovine) - LIF gene LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes (By similarity). Taurus_UMD|evm.model.AC_000174.1.558 P53346 ONCM_BOVIN 99.153 0.987395 0.971429 OSM - Oncostatin-M precursor - Bos taurus (Bovine) - OSM gene Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST) (By similarity). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). Taurus_UMD|evm.model.AC_000174.1.559 Q0V8A3 CAST1_BOVIN 100.000 0.993939 1.00304 CASTOR1 - Cytosolic arginine sensor for mTORC1 subunit 1 - Bos taurus (Bovine) - CASTOR1 gene Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. Taurus_UMD|evm.model.AC_000174.1.560 Q9BXI6 TB10A_HUMAN 89.954 0.984163 0.870079 TBC1D10A - TBC1 domain family member 10A - Homo sapiens (Human) - TBC1D10A gene Acts as GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A. Taurus_UMD|evm.model.AC_000174.1.561 A2VDN6 SF3A1_BOVIN 100.000 0.997481 1.00126 SF3A1 - Splicing factor 3A subunit 1 - Bos taurus (Bovine) - SF3A1 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes. Taurus_UMD|evm.model.AC_000174.1.562 A4IFI1 CC157_BOVIN 95.224 0.997041 0.982558 CCDC157 - Coiled-coil domain-containing protein 157 - Bos taurus (Bovine) - CCDC157 gene Taurus_UMD|evm.model.AC_000174.1.563 Q9Y6U7 RN215_HUMAN 85.278 0.893035 1.06631 RNF215 - RING finger protein 215 - Homo sapiens (Human) - RNF215 gene endosome, Golgi transport complex, membrane, trans-Golgi network, ubiquitin protein ligase activity, Golgi to vacuole transport, protein targeting to vacuole, ubiquitin-dependent protein catabolic process Taurus_UMD|evm.model.AC_000174.1.565 P58875 S14L2_BOVIN 99.752 0.99505 1.00248 SEC14L2 - SEC14-like protein 2 - Bos taurus (Bovine) - SEC14L2 gene Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell (By similarity). Taurus_UMD|evm.model.AC_000174.1.566 Q9UDX5 MTFP1_HUMAN 90.964 0.988024 1.00602 MTFP1 - Mitochondrial fission process protein 1 - Homo sapiens (Human) - MTFP1 gene Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis. Taurus_UMD|evm.model.AC_000174.1.567 Q9Z1J8 S14L3_RAT 96.500 0.995012 1.0025 Sec14l3 - SEC14-like protein 3 - Rattus norvegicus (Rat) - Sec14l3 gene Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids. Taurus_UMD|evm.model.AC_000174.1.568 Q9UDX3 S14L4_HUMAN 82.759 0.462857 2.15517 SEC14L4 - SEC14-like protein 4 - Homo sapiens (Human) - SEC14L4 gene Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids. Taurus_UMD|evm.model.AC_000174.1.569 A6QNK1 G3ST1_BOVIN 95.918 0.948052 0.364066 GAL3ST1 - Galactosylceramide sulfotransferase - Bos taurus (Bovine) - GAL3ST1 gene Catalyzes the transfer of a sulfate group to position 3 of non-reducing beta-galactosyl residues in glycerolipids and sphingolipids, therefore participates to the biosynthesis of sulfoglycolipids. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). Taurus_UMD|evm.model.AC_000174.1.570 A6QNK1 G3ST1_BOVIN 88.915 0.914286 0.992908 GAL3ST1 - Galactosylceramide sulfotransferase - Bos taurus (Bovine) - GAL3ST1 gene Catalyzes the transfer of a sulfate group to position 3 of non-reducing beta-galactosyl residues in glycerolipids and sphingolipids, therefore participates to the biosynthesis of sulfoglycolipids. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). Taurus_UMD|evm.model.AC_000174.1.571 O00541 PESC_HUMAN 77.670 0.993162 0.994898 PES1 - Pescadillo homolog - Homo sapiens (Human) - PES1 gene Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Taurus_UMD|evm.model.AC_000174.1.572 Q9XSC9 TCO2_BOVIN 100.000 0.995381 1.00231 TCN2 - Transcobalamin-2 precursor - Bos taurus (Bovine) - TCN2 gene Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. Taurus_UMD|evm.model.AC_000174.1.573 Q6ICL7 S35E4_HUMAN 88.857 0.994302 1.00286 SLC35E4 - Solute carrier family 35 member E4 - Homo sapiens (Human) - SLC35E4 gene Putative transporter. Taurus_UMD|evm.model.AC_000174.1.574 Q5BIP9 DUS18_BOVIN 100.000 0.989418 1.00532 DUSP18 - Dual specificity protein phosphatase 18 - Bos taurus (Bovine) - DUSP18 gene Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). Taurus_UMD|evm.model.AC_000174.1.575 A6NGY3 CE052_HUMAN 63.333 0.764103 1.22642 C5orf52 - Uncharacterized protein C5orf52 - Homo sapiens (Human) - C5orf52 gene Taurus_UMD|evm.model.AC_000174.1.576 Q969R2 OSBP2_HUMAN 80.736 0.997819 1.00109 OSBP2 - Oxysterol-binding protein 2 - Homo sapiens (Human) - OSBP2 gene Binds 7-ketocholesterol. Taurus_UMD|evm.model.AC_000174.1.577 Q9Y6X9 MORC2_HUMAN 92.219 0.998077 1.00775 MORC2 - ATPase MORC2 - Homo sapiens (Human) - MORC2 gene Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20225202, PubMed:20110259). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). Taurus_UMD|evm.model.AC_000174.1.579 P53814 SMTN_HUMAN 83.664 0.985635 0.986914 SMTN - Smoothelin - Homo sapiens (Human) - SMTN gene Structural protein of the cytoskeleton. Taurus_UMD|evm.model.AC_000174.1.580 Q921U8 SMTN_MOUSE 100.000 0.360902 0.144095 Smtn - Smoothelin - Mus musculus (Mouse) - Smtn gene Structural protein of the cytoskeleton. Taurus_UMD|evm.model.AC_000174.1.581 Q8WWX9 SELM_HUMAN 74.790 0.347541 2.10345 SELENOM - Selenoprotein M precursor - Homo sapiens (Human) - SELENOM gene May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation. Taurus_UMD|evm.model.AC_000174.1.582 Q15735 PI5PA_HUMAN 85.035 0.972789 1.02286 INPP5J - Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A - Homo sapiens (Human) - INPP5J gene Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity). Taurus_UMD|evm.model.AC_000174.1.583 Q1JPB9 PA2G3_BOVIN 79.592 0.945841 1.03194 PLA2G3 - Group 3 secretory phospholipase A2 precursor - Bos taurus (Bovine) - PLA2G3 gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids without apparent head group selectivity (By similarity). Contributes to phospholipid remodeling of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (By similarity). May act in an autocrine and paracrine manner. Secreted by immature mast cells, acts on nearby fibroblasts upstream to PTDGS to synthesize prostaglandin D2 (PGD2), which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). Secreted by epididymal epithelium, acts on immature sperm cells within the duct, modulating the degree of unsaturation of the fatty acyl components of phosphatidylcholines required for acrosome assembly and sperm cell motility. Facilitates the replacement of fatty acyl chains in phosphatidylcholines in sperm membranes from omega-6 and omega-9 to omega-3 polyunsaturated fatty acids (PUFAs). Coupled to lipoxygenase pathway, may process omega-6 PUFAs to generate oxygenated lipid mediators in the male reproductive tract (By similarity). At pericentrosomal preciliary compartment, negatively regulates ciliogenesis likely by regulating endocytotic recycling of ciliary membrane protein (By similarity). Coupled to cyclooxygenase pathway provides arachidonate to generate prostaglandin E2 (PGE2), a potent immunomodulatory lipid in inflammation and tumorigenesis (By similarity). At colonic epithelial barrier, preferentially hydrolyzes phospholipids having arachidonate and docosahexaenoate at sn-2 position, contributing to the generation of oxygenated metabolites involved in colonic stem cell homeostasis (By similarity). Releases C16:0 and C18:0 lysophosphatidylcholine subclasses from neuron plasma membranes and promotes neurite outgrowth and neuron survival (By similarity). Taurus_UMD|evm.model.AC_000174.1.584 Q96GF1 RN185_HUMAN 98.438 0.989637 1.00521 RNF185 - E3 ubiquitin-protein ligase RNF185 - Homo sapiens (Human) - RNF185 gene E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693). Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036). Protects cells from ER stress-induced apoptosis (PubMed:27485036). Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521). Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521). Taurus_UMD|evm.model.AC_000174.1.585 Q32L23 LIMK2_BOVIN 99.843 0.99687 1.00157 LIMK2 - LIM domain kinase 2 - Bos taurus (Bovine) - LIMK2 gene Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity). Taurus_UMD|evm.model.AC_000174.1.586 Q1RMT9 P3IP1_BOVIN 100.000 0.973783 1.02299 PIK3IP1 - Phosphoinositide-3-kinase-interacting protein 1 precursor - Bos taurus (Bovine) - PIK3IP1 gene Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity. Taurus_UMD|evm.model.AC_000174.1.587 Q9HBE1 PATZ1_HUMAN 92.576 0.996885 0.934498 PATZ1 - POZ-, AT hook-, and zinc finger-containing protein 1 - Homo sapiens (Human) - PATZ1 gene Transcriptional repressor. Taurus_UMD|evm.model.AC_000174.1.588 Q9Y295 DRG1_HUMAN 100.000 0.994565 1.00272 DRG1 - Developmentally-regulated GTP-binding protein 1 - Homo sapiens (Human) - DRG1 gene Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). Taurus_UMD|evm.model.AC_000174.1.589 Q9NRA8 4ET_HUMAN 95.431 0.99797 1 EIF4ENIF1 - Eukaryotic translation initiation factor 4E transporter - Homo sapiens (Human) - EIF4ENIF1 gene EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). Taurus_UMD|evm.model.AC_000174.1.590 A8K8P3 SFI1_HUMAN 64.313 0.998441 1.03301 SFI1 - Protein SFI1 homolog - Homo sapiens (Human) - SFI1 gene Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2. Taurus_UMD|evm.model.AC_000174.1.591 Q58DH2 PISD_BOVIN 100.000 0.735941 0.983173 PISD - Phosphatidylserine decarboxylase proenzyme, mitochondrial precursor - Bos taurus (Bovine) - PISD gene Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Taurus_UMD|evm.model.AC_000174.1.592 Q5THK1 PR14L_HUMAN 59.936 0.999057 0.986518 PRR14L - Protein PRR14L - Homo sapiens (Human) - PRR14L gene Taurus_UMD|evm.model.AC_000174.1.593 O75140 DEPD5_HUMAN 94.198 0.998745 0.994386 DEPDC5 - GATOR complex protein DEPDC5 - Homo sapiens (Human) - DEPDC5 gene As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. Taurus_UMD|evm.model.AC_000174.1.594 P68511 1433F_RAT 100.000 0.892562 0.98374 Ywhah - 14-3-3 protein eta - Rattus norvegicus (Rat) - Ywhah gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). Taurus_UMD|evm.model.AC_000174.1.595 P53791 SC5A1_SHEEP 94.428 0.99688 0.965361 SLC5A1 - Sodium/glucose cotransporter 1 - Ovis aries (Sheep) - SLC5A1 gene Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Taurus_UMD|evm.model.AC_000174.1.596 P31636 SC5A4_PIG 93.636 0.996974 1.00152 SLC5A4 - Solute carrier family 5 member 4 - Sus scrofa (Pig) - SLC5A4 gene Has electrogenic activity in response to glucose, and may function as a glucose sensor (PubMed:8077195). Also has low-affinity sodium/glucose cotransporter activity; sugar transport activity is tightly coupled to ion transport at neutral pH but is reduced under more acidic conditions (PubMed:8077195, PubMed:13130073). Taurus_UMD|evm.model.AC_000174.1.597 A0A075B6I7 LV548_HUMAN 79.048 0.350168 2.82857 IGLV5-48 - Probable non-functional immunoglobulin lambda variable 5-48 precursor - Homo sapiens (Human) - IGLV5-48 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Taurus_UMD|evm.model.AC_000174.1.598 P0DOX8 IGL1_HUMAN 74.468 0.315254 1.36574 Immunoglobulin lambda-1 light chain - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000174.1.599 A0A075B6I0 LV861_HUMAN 75.214 0.387205 2.43443 IGLV8-61 - Immunoglobulin lambda variable 8-61 precursor - Homo sapiens (Human) - IGLV8-61 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.600 P01703 LV140_HUMAN 83.673 0.214286 1.89831 IGLV1-40 - Immunoglobulin lambda variable 1-40 precursor - Homo sapiens (Human) - IGLV1-40 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.601 P01703 LV140_HUMAN 70.175 0.807143 1.18644 IGLV1-40 - Immunoglobulin lambda variable 1-40 precursor - Homo sapiens (Human) - IGLV1-40 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.602 P01703 LV140_HUMAN 70.435 0.447059 2.16102 IGLV1-40 - Immunoglobulin lambda variable 1-40 precursor - Homo sapiens (Human) - IGLV1-40 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.603 A0A075B6I0 LV861_HUMAN 57.391 0.916667 0.786885 IGLV8-61 - Immunoglobulin lambda variable 8-61 precursor - Homo sapiens (Human) - IGLV8-61 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.604 A0A075B6I0 LV861_HUMAN 76.471 0.348432 2.35246 IGLV8-61 - Immunoglobulin lambda variable 8-61 precursor - Homo sapiens (Human) - IGLV8-61 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.605 A0A0B4J1U3 LV136_HUMAN 70.588 0.0679012 4.15385 IGLV1-36 - Immunoglobulin lambda variable 1-36 precursor - Homo sapiens (Human) - IGLV1-36 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.606 P01703 LV140_HUMAN 70.435 0.726115 1.33051 IGLV1-40 - Immunoglobulin lambda variable 1-40 precursor - Homo sapiens (Human) - IGLV1-40 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.608 P01703 LV140_HUMAN 73.077 0.76 0.847458 IGLV1-40 - Immunoglobulin lambda variable 1-40 precursor - Homo sapiens (Human) - IGLV1-40 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.609 P01703 LV140_HUMAN 74.312 0.572193 1.58475 IGLV1-40 - Immunoglobulin lambda variable 1-40 precursor - Homo sapiens (Human) - IGLV1-40 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.610 Q86YH2 Z280B_HUMAN 78.077 0.945055 1.00552 ZNF280B - Zinc finger protein 280B - Homo sapiens (Human) - ZNF280B gene May function as a transcription factor. Taurus_UMD|evm.model.AC_000174.1.611 P78395 PRAME_HUMAN 50.870 0.885312 0.976424 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Taurus_UMD|evm.model.AC_000174.1.612 P01714 LV319_HUMAN 78.947 0.371542 2.25893 IGLV3-19 - Immunoglobulin lambda variable 3-19 precursor - Homo sapiens (Human) - IGLV3-19 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.613 P01717 LV325_HUMAN 82.143 0.596774 1.66071 IGLV3-25 - Immunoglobulin lambda variable 3-25 precursor - Homo sapiens (Human) - IGLV3-25 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.614 P0CG04 IGLC1_HUMAN 75.238 0.245863 3.99057 IGLC1 - Immunoglobulin lambda constant 1 - Homo sapiens (Human) - IGLC1 gene Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.615 P0CG04 IGLC1_HUMAN 76.415 0.76087 1.30189 IGLC1 - Immunoglobulin lambda constant 1 - Homo sapiens (Human) - IGLC1 gene Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.616 P0DOY3 IGLC3_HUMAN 85.000 0.361111 1.01887 IGLC3 - Immunoglobulin lambda constant 3 - Homo sapiens (Human) - IGLC3 gene Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.617 Q9UC06 ZNF70_HUMAN 78.348 0.984581 1.01794 ZNF70 - Zinc finger protein 70 - Homo sapiens (Human) - ZNF70 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000174.1.618 Q9UKI3 VPRE3_HUMAN 70.339 0.959016 0.99187 VPREB3 - Pre-B lymphocyte protein 3 precursor - Homo sapiens (Human) - VPREB3 gene Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. Taurus_UMD|evm.model.AC_000174.1.619 Q8WYQ4 CV015_HUMAN 63.014 0.911392 0.533784 C22orf15 - Uncharacterized protein C22orf15 - Homo sapiens (Human) - C22orf15 gene Taurus_UMD|evm.model.AC_000174.1.620 Q8WYQ3 CHC10_HUMAN 92.308 0.986111 1.01408 CHCHD10 - Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial precursor - Homo sapiens (Human) - CHCHD10 gene May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. Taurus_UMD|evm.model.AC_000174.1.621 P24347 MMP11_HUMAN 85.809 0.935551 0.985656 MMP11 - Stromelysin-3 precursor - Homo sapiens (Human) - MMP11 gene May play an important role in the progression of epithelial malignancies. Taurus_UMD|evm.model.AC_000174.1.622 Q5BIN2 SNF5_BOVIN 100.000 0.994805 1 SMARCB1 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 - Bos taurus (Bovine) - SMARCB1 gene Core component of the BAF (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Taurus_UMD|evm.model.AC_000174.1.623 Q0P5E4 DERL3_BOVIN 99.134 0.991379 1.00433 DERL3 - Derlin-3 - Bos taurus (Bovine) - DERL3 gene Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins. May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Taurus_UMD|evm.model.AC_000174.1.624 Q9BYW1 GTR11_HUMAN 82.389 0.924953 1.0746 SLC2A11 - Solute carrier family 2, facilitated glucose transporter member 11 - Homo sapiens (Human) - SLC2A11 gene Facilitative glucose transporter. Taurus_UMD|evm.model.AC_000174.1.625 Q1ZZU7 MIF_SHEEP 100.000 0.982759 1.0087 MIF - Macrophage migration inhibitory factor - Ovis aries (Sheep) - MIF gene Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity). Taurus_UMD|evm.model.AC_000174.1.626 P0CG29 GST2_HUMAN 45.556 0.617424 1.08197 GSTT2 - Glutathione S-transferase theta-2 - Homo sapiens (Human) - GSTT2 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity. Taurus_UMD|evm.model.AC_000174.1.627 Q9D4P7 GSTT4_MOUSE 85.477 0.991736 1.00833 Gstt4 - Glutathione S-transferase theta-4 - Mus musculus (Mouse) - Gstt4 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Taurus_UMD|evm.model.AC_000174.1.628 Q2NL00 GSTT1_BOVIN 100.000 0.991701 1.00417 GSTT1 - Glutathione S-transferase theta-1 - Bos taurus (Bovine) - GSTT1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity. Taurus_UMD|evm.model.AC_000174.1.629 Q99L20 GSTT3_MOUSE 80.000 0.843972 1.17012 Gstt3 - Glutathione S-transferase theta-3 - Mus musculus (Mouse) - Gstt3 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows high activity towards 4-nitrobenzyl chloride (4-NBC). Also has lower activity towards 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP), cumene hydroperoxide, 1-chloro-2,4-dinitrobenzene (CDNB), 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl), and ethacrynic acid. Taurus_UMD|evm.model.AC_000174.1.630 A5PK65 DOPD_BOVIN 84.348 0.0501761 19.2542 DDT - D-dopachrome decarboxylase - Bos taurus (Bovine) - DDT gene Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Taurus_UMD|evm.model.AC_000174.1.631 Q9UGT4 SUSD2_HUMAN 77.494 0.997567 1 SUSD2 - Sushi domain-containing protein 2 precursor - Homo sapiens (Human) - SUSD2 gene May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994). Taurus_UMD|evm.model.AC_000174.1.632 P36269 GGT5_HUMAN 79.181 0.996497 0.974403 GGT5 - Glutathione hydrolase 5 proenzyme precursor - Homo sapiens (Human) - GGT5 gene Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate such as leukotriene C4 (PubMed:21447318). Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine (PubMed:21447318). May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:21447318). Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses (PubMed:30842656). Taurus_UMD|evm.model.AC_000174.1.633 P20735 GGT1_PIG 87.823 0.651807 1.46127 GGT1 - Glutathione hydrolase 1 proenzyme precursor - Sus scrofa (Pig) - GGT1 gene Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates and other gamma-glutamyl compounds, such as leukotriene C4 (LTC4). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4. Taurus_UMD|evm.model.AC_000174.1.634 Q2VPJ9 LR75B_HUMAN 37.696 0.978261 0.584127 LRRC75B - Leucine-rich repeat-containing protein 75B - Homo sapiens (Human) - LRRC75B gene cytoplasm Taurus_UMD|evm.model.AC_000174.1.635 P62323 SMD3_XENLA 100.000 0.357143 2.77778 snrpd3 - Small nuclear ribonucleoprotein Sm D3 - Xenopus laevis (African clawed frog) - snrpd3 gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). Taurus_UMD|evm.model.AC_000174.1.637 Q9UBR1 BUP1_HUMAN 87.240 0.994805 1.0026 UPB1 - Beta-ureidopropionase - Homo sapiens (Human) - UPB1 gene Catalyzes a late step in pyrimidine degradation (PubMed:22525402, PubMed:24526388). Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide (PubMed:10542323, PubMed:11508704, PubMed:10415095, PubMed:29976570, PubMed:22525402, PubMed:24526388). Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide (Probable). Taurus_UMD|evm.model.AC_000174.1.639 P11617 AA2AR_CANLF 82.152 0.985075 0.975728 ADORA2A - Adenosine receptor A2a - Canis lupus familiaris (Dog) - ADORA2A gene Receptor for adenosine (PubMed:2125216). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:2125216). Taurus_UMD|evm.model.AC_000174.1.640 Q2KNA1 CYTSA_PANTR 92.672 0.998214 1.00269 SPECC1L - Cytospin-A - Pan troglodytes (Chimpanzee) - SPECC1L gene Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity). Taurus_UMD|evm.model.AC_000174.1.642 P11274 BCR_HUMAN 92.593 0.770115 0.8214 BCR - Breakpoint cluster region protein - Homo sapiens (Human) - BCR gene Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). Taurus_UMD|evm.model.AC_000174.1.643 F1LXF1 BCR_RAT 94.444 0.473333 0.141243 Bcr - Breakpoint cluster region protein - Rattus norvegicus (Rat) - Bcr gene Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The amino terminus contains an intrinsic kinase activity (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity. Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (By similarity). Taurus_UMD|evm.model.AC_000174.1.645 O95755 RAB36_HUMAN 87.266 0.992537 0.804805 RAB36 - Ras-related protein Rab-36 - Homo sapiens (Human) - RAB36 gene Protein transport. Probably involved in vesicular traffic (By similarity). Taurus_UMD|evm.model.AC_000174.1.647 Q9D3W1 RSP14_MOUSE 72.667 0.908537 0.480938 Rsph14 - Radial spoke head 14 homolog - Mus musculus (Mouse) - Rsph14 gene Taurus_UMD|evm.model.AC_000174.1.648 P19627 GNAZ_RAT 95.798 0.951807 0.701408 Gnaz - Guanine nucleotide-binding protein G(z) subunit alpha - Rattus norvegicus (Rat) - Gnaz gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Taurus_UMD|evm.model.AC_000174.1.649 Q9D3W1 RSP14_MOUSE 70.936 0.736264 0.800587 Rsph14 - Radial spoke head 14 homolog - Mus musculus (Mouse) - Rsph14 gene Taurus_UMD|evm.model.AC_000174.1.650 P53791 SC5A1_SHEEP 56.231 0.968843 1.01506 SLC5A1 - Sodium/glucose cotransporter 1 - Ovis aries (Sheep) - SLC5A1 gene Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Taurus_UMD|evm.model.AC_000174.1.651 P0CG04 IGLC1_HUMAN 70.476 0.492891 1.99057 IGLC1 - Immunoglobulin lambda constant 1 - Homo sapiens (Human) - IGLC1 gene Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.652 O95985 TOP3B_HUMAN 91.250 0.897727 0.204176 TOP3B - DNA topoisomerase 3-beta-1 - Homo sapiens (Human) - TOP3B gene Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity. Taurus_UMD|evm.model.AC_000174.1.653 P12018 VPREB_HUMAN 70.339 0.764706 1.05517 VPREB1 - Immunoglobulin iota chain precursor - Homo sapiens (Human) - VPREB1 gene Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation. Taurus_UMD|evm.model.AC_000174.1.654 O95985 TOP3B_HUMAN 94.056 0.600536 1.29814 TOP3B - DNA topoisomerase 3-beta-1 - Homo sapiens (Human) - TOP3B gene Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity. Taurus_UMD|evm.model.AC_000174.1.655 P46196 MK01_BOVIN 97.583 0.772834 1.18611 MAPK1 - Mitogen-activated protein kinase 1 - Bos taurus (Bovine) - MAPK1 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint (By similarity). Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2. Taurus_UMD|evm.model.AC_000174.1.658 Q14129 DGCR6_HUMAN 97.468 0.848649 0.840909 DGCR6 - Protein DGCR6 - Homo sapiens (Human) - DGCR6 gene May play a role in neural crest cell migration into the third and fourth pharyngeal pouches. Taurus_UMD|evm.model.AC_000174.1.659 O60688 YPEL1_HUMAN 99.160 0.791946 1.2521 YPEL1 - Protein yippee-like 1 - Homo sapiens (Human) - YPEL1 gene May play a role in epithelioid conversion of fibroblasts. Taurus_UMD|evm.model.AC_000174.1.660 Q13356 PPIL2_HUMAN 90.805 0.996176 1.00577 PPIL2 - RING-type E3 ubiquitin-protein ligase PPIL2 - Homo sapiens (Human) - PPIL2 gene Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). Taurus_UMD|evm.model.AC_000174.1.662 Q3T083 SDF2L_BOVIN 100.000 0.990991 1.00452 SDF2L1 - Stromal cell-derived factor 2-like protein 1 precursor - Bos taurus (Bovine) - SDF2L1 gene Taurus_UMD|evm.model.AC_000174.1.663 Q95LR6 CC116_MACFA 63.438 0.60597 1.26894 CCDC116 - Coiled-coil domain-containing protein 116 - Macaca fascicularis (Crab-eating macaque) - CCDC116 gene centrosome Taurus_UMD|evm.model.AC_000174.1.664 Q14BV6 YDJC_MOUSE 85.668 0.944444 1.04516 Ydjc - Carbohydrate deacetylase - Mus musculus (Mouse) - Ydjc gene Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. Taurus_UMD|evm.model.AC_000174.1.665 P68037 UB2L3_MOUSE 99.320 0.637555 1.48701 Ube2l3 - Ubiquitin-conjugating enzyme E2 L3 - Mus musculus (Mouse) - Ube2l3 gene Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. Taurus_UMD|evm.model.AC_000174.1.666 A6NNM3 RIM3B_HUMAN 59.650 0.998127 0.977425 RIMBP3B - RIMS-binding protein 3B - Homo sapiens (Human) - RIMBP3B gene Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. Taurus_UMD|evm.model.AC_000174.1.667 Q96JB3 HIC2_HUMAN 83.806 0.996639 0.96748 HIC2 - Hypermethylated in cancer 2 protein - Homo sapiens (Human) - HIC2 gene Transcriptional repressor. Taurus_UMD|evm.model.AC_000174.1.668 Q9JJB1 T191C_MOUSE 79.801 0.993377 1 Tmem191c - Transmembrane protein 191C - Mus musculus (Mouse) - Tmem191c gene Taurus_UMD|evm.model.AC_000174.1.669 O02811 PI4KA_BOVIN 100.000 0.999049 1.00048 PI4KA - Phosphatidylinositol 4-kinase alpha - Bos taurus (Bovine) - PI4KA gene Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. Taurus_UMD|evm.model.AC_000174.1.670 Q0II86 SNP29_BOVIN 100.000 0.676471 1.44961 SNAP29 - Synaptosomal-associated protein 29 - Bos taurus (Bovine) - SNAP29 gene SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. Taurus_UMD|evm.model.AC_000174.1.671 P46109 CRKL_HUMAN 75.578 0.992032 0.828383 CRKL - Crk-like protein - Homo sapiens (Human) - CRKL gene May mediate the transduction of intracellular signals. Taurus_UMD|evm.model.AC_000174.1.673 Q96NN9 AIFM3_HUMAN 93.223 0.996661 0.990083 AIFM3 - Apoptosis-inducing factor 3 - Homo sapiens (Human) - AIFM3 gene Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential. Taurus_UMD|evm.model.AC_000174.1.674 Q8N653 LZTR1_HUMAN 93.222 0.997602 0.992857 LZTR1 - Leucine-zipper-like transcriptional regulator 1 - Homo sapiens (Human) - LZTR1 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304). Taurus_UMD|evm.model.AC_000174.1.675 Q9BT49 THAP7_HUMAN 71.845 0.992218 0.831715 THAP7 - THAP domain-containing protein 7 - Homo sapiens (Human) - THAP7 gene Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors. Taurus_UMD|evm.model.AC_000174.1.676 Q68FR8 TBA3_RAT 100.000 0.995565 1.00222 Tuba3a - Tubulin alpha-3 chain - Rattus norvegicus (Rat) - Tuba3a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Taurus_UMD|evm.model.AC_000174.1.677 Q6ZQY2 LR74B_HUMAN 78.796 0.984496 0.987245 LRRC74B - Leucine-rich repeat-containing protein 74B - Homo sapiens (Human) - LRRC74B gene Taurus_UMD|evm.model.AC_000174.1.678 O15547 P2RX6_HUMAN 82.552 0.972081 0.893424 P2RX6 - P2X purinoceptor 6 - Homo sapiens (Human) - P2RX6 gene Receptor for ATP that acts as a ligand-gated ion channel. Taurus_UMD|evm.model.AC_000174.1.679 O43246 CTR4_HUMAN 74.367 0.993651 0.992126 SLC7A4 - Cationic amino acid transporter 4 - Homo sapiens (Human) - SLC7A4 gene Involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Taurus_UMD|evm.model.AC_000174.1.680 Q68FR8 TBA3_RAT 100.000 0.995565 1.00222 Tuba3a - Tubulin alpha-3 chain - Rattus norvegicus (Rat) - Tuba3a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Taurus_UMD|evm.model.AC_000174.1.681 A5PJV8 MZT2_BOVIN 100.000 0.987421 1.00633 MZT2 - Mitotic-spindle organizing protein 2 - Bos taurus (Bovine) - MZT2 gene centrosome, gamma-tubulin ring complex, spindle Taurus_UMD|evm.model.AC_000174.1.682 Q9NXE4 NSMA3_HUMAN 87.544 0.991755 0.98037 SMPD4 - Sphingomyelin phosphodiesterase 4 - Homo sapiens (Human) - SMPD4 gene Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606, PubMed:25180167). It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function (PubMed:31495489). May sensitize cells to DNA damage-induced apoptosis (PubMed:18505924). In skeletal muscle, mediates TNF-stimulated oxidant production (By similarity). Taurus_UMD|evm.model.AC_000174.1.683 Q96LY2 CC74B_HUMAN 49.510 0.99403 0.881579 CCDC74B - Coiled-coil domain-containing protein 74B - Homo sapiens (Human) - CCDC74B gene Taurus_UMD|evm.model.AC_000174.1.684 Q6NS15 MED15_XENLA 84.658 0.511236 0.916345 med15 - Mediator of RNA polymerase II transcription subunit 15 - Xenopus laevis (African clawed frog) - med15 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation (By similarity). Positively regulates the Nodal signaling pathway. Taurus_UMD|evm.model.AC_000174.1.685 Q53GT1 KLH22_HUMAN 94.164 0.99685 1.00158 KLHL22 - Kelch-like protein 22 - Homo sapiens (Human) - KLHL22 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation (PubMed:19995937, PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy (PubMed:29769719). Taurus_UMD|evm.model.AC_000174.1.686 Q96GP6 SREC2_HUMAN 86.416 0.997616 0.963261 SCARF2 - Scavenger receptor class F member 2 precursor - Homo sapiens (Human) - SCARF2 gene Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity). Taurus_UMD|evm.model.AC_000174.1.688 Q16587 ZNF74_HUMAN 64.417 0.982595 0.981366 ZNF74 - Zinc finger protein 74 - Homo sapiens (Human) - ZNF74 gene May play a role in RNA metabolism. Taurus_UMD|evm.model.AC_000174.1.689 A0A494C0N9 F246B_HUMAN 77.966 0.522523 0.478448 FAM246B - Protein FAM246B - Homo sapiens (Human) - FAM246B gene Taurus_UMD|evm.model.AC_000174.1.691 P98153 IDD_HUMAN 85.305 0.931532 1.00909 DGCR2 - Integral membrane protein DGCR2/IDD precursor - Homo sapiens (Human) - DGCR2 gene Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration. Taurus_UMD|evm.model.AC_000174.1.692 Q3SZW1 TSSK1_BOVIN 99.728 0.994565 1.00272 TSSK1B - Testis-specific serine/threonine-protein kinase 1 - Bos taurus (Bovine) - TSSK1B gene Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body (By similarity). Taurus_UMD|evm.model.AC_000174.1.693 O54863 TSSK2_MOUSE 94.693 0.994429 1.00279 Tssk2 - Testis-specific serine/threonine-protein kinase 2 - Mus musculus (Mouse) - Tssk2 gene Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-281' of TSKS and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. Taurus_UMD|evm.model.AC_000174.1.694 Q96DF8 ESS2_HUMAN 90.167 0.995825 1.0063 ESS2 - Splicing factor ESS-2 homolog - Homo sapiens (Human) - ESS2 gene May be involved in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000174.1.695 P56916 GSC2_MOUSE 87.059 0.428571 0.989899 Gsc2 - Homeobox protein goosecoid-2 - Mus musculus (Mouse) - Gsc2 gene May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC. Taurus_UMD|evm.model.AC_000174.1.696 P79110 TXTP_BOVIN 98.208 0.519626 1.72026 SLC25A1 - Tricarboxylate transport protein, mitochondrial precursor - Bos taurus (Bovine) - SLC25A1 gene Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Taurus_UMD|evm.model.AC_000174.1.697 P54198 HIRA_HUMAN 90.307 0.891247 1.11209 HIRA - Protein HIRA - Homo sapiens (Human) - HIRA gene Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Taurus_UMD|evm.model.AC_000174.1.698 Q9NQ50 RM40_HUMAN 72.816 0.990338 1.00485 MRPL40 - 39S ribosomal protein L40, mitochondrial precursor - Homo sapiens (Human) - MRPL40 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, nucleolus, nucleus, RNA binding, anatomical structure morphogenesis, mitochondrial translational elongation, mitochondrial translational termination Taurus_UMD|evm.model.AC_000174.1.699 Q3SZ70 CV039_BOVIN 100.000 0.236842 2.55769 UPF0545 protein C22orf39 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000174.1.700 Q92890 UFD1_HUMAN 97.720 0.993506 1.00326 UFD1 - Ubiquitin recognition factor in ER-associated degradation protein 1 - Homo sapiens (Human) - UFD1 gene Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). Taurus_UMD|evm.model.AC_000174.1.701 O75419 CDC45_HUMAN 90.300 0.996473 1.00177 CDC45 - Cell division control protein 45 homolog - Homo sapiens (Human) - CDC45 gene Required for initiation of chromosomal DNA replication. Taurus_UMD|evm.model.AC_000174.1.702 Q2HJ22 CLD5_BOVIN 100.000 0.653614 1.52294 CLDN5 - Claudin-5 - Bos taurus (Bovine) - CLDN5 gene Plays a major role in tight junction-specific obliteration of the intercellular space. Taurus_UMD|evm.model.AC_000174.1.705 Q0VC68 SEPT5_BOVIN 99.716 0.926121 1.0271 SEPTIN5 - Septin-5 - Bos taurus (Bovine) - SEPTIN5 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity). Taurus_UMD|evm.model.AC_000174.1.706 P13224 GP1BB_HUMAN 89.116 0.708738 1 GP1BB - Platelet glycoprotein Ib beta chain precursor - Homo sapiens (Human) - GP1BB gene Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium. Taurus_UMD|evm.model.AC_000174.1.707 O43435 TBX1_HUMAN 98.958 0.477387 0.5 TBX1 - T-box transcription factor TBX1 - Homo sapiens (Human) - TBX1 gene Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity). Taurus_UMD|evm.model.AC_000174.1.708 O43435 TBX1_HUMAN 85.714 0.344633 0.444724 TBX1 - T-box transcription factor TBX1 - Homo sapiens (Human) - TBX1 gene Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity). Taurus_UMD|evm.model.AC_000174.1.709 Q9BYB4 GNB1L_HUMAN 73.482 0.960784 0.93578 GNB1L - Guanine nucleotide-binding protein subunit beta-like protein 1 - Homo sapiens (Human) - GNB1L gene cytoplasmic side of plasma membrane, G protein-coupled receptor signaling pathway, intracellular signal transduction Taurus_UMD|evm.model.AC_000174.1.711 Q7L3V2 BOP_HUMAN 45.833 0.256809 0.706044 RTL10 - Protein Bop - Homo sapiens (Human) - RTL10 gene Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity. Taurus_UMD|evm.model.AC_000174.1.712 Q9N2I8 TRXR2_BOVIN 93.210 0.991228 0.892368 TXNRD2 - Thioredoxin reductase 2, mitochondrial precursor - Bos taurus (Bovine) - TXNRD2 gene Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling. Taurus_UMD|evm.model.AC_000174.1.713 A7MBI7 COMT_BOVIN 98.980 0.692857 0.514706 COMT - Catechol O-methyltransferase - Bos taurus (Bovine) - COMT gene Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Taurus_UMD|evm.model.AC_000174.1.715 O00192 ARVC_HUMAN 88.174 0.997899 0.989605 ARVCF - Armadillo repeat protein deleted in velo-cardio-facial syndrome - Homo sapiens (Human) - ARVCF gene Involved in protein-protein interactions at adherens junctions. Taurus_UMD|evm.model.AC_000174.1.718 Q29RZ5 TNG2_BOVIN 99.333 0.620833 0.869565 TANGO2 - Transport and Golgi organization protein 2 homolog - Bos taurus (Bovine) - TANGO2 gene Golgi apparatus, Golgi organization, protein secretion Taurus_UMD|evm.model.AC_000174.1.719 Q29RZ5 TNG2_BOVIN 100.000 0.776398 0.583333 TANGO2 - Transport and Golgi organization protein 2 homolog - Bos taurus (Bovine) - TANGO2 gene Golgi apparatus, Golgi organization, protein secretion Taurus_UMD|evm.model.AC_000174.1.720 A6QR44 DGCR8_BOVIN 94.881 0.997506 1.05526 DGCR8 - Microprocessor complex subunit DGCR8 - Bos taurus (Bovine) - DGCR8 gene Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (By similarity). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Taurus_UMD|evm.model.AC_000174.1.721 Q8IZ69 TRM2A_HUMAN 75.637 0.996587 0.9376 TRMT2A - tRNA (uracil-5-)-methyltransferase homolog A - Homo sapiens (Human) - TRMT2A gene May be involved in nucleic acid metabolism and/or modifications. Taurus_UMD|evm.model.AC_000174.1.722 Q3T0M7 RANG_BOVIN 100.000 0.80315 0.616505 RANBP1 - Ran-specific GTPase-activating protein - Bos taurus (Bovine) - RANBP1 gene Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN. Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (By similarity). Taurus_UMD|evm.model.AC_000174.1.723 Q3T0M7 RANG_BOVIN 99.029 0.927273 0.533981 RANBP1 - Ran-specific GTPase-activating protein - Bos taurus (Bovine) - RANBP1 gene Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN. Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (By similarity). Taurus_UMD|evm.model.AC_000174.1.725 Q9ULC8 ZDHC8_HUMAN 100.000 0.0509745 0.871895 ZDHHC8 - Palmitoyltransferase ZDHHC8 - Homo sapiens (Human) - ZDHHC8 gene Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). Taurus_UMD|evm.model.AC_000174.1.726 H7C350 CC188_HUMAN 68.458 0.85743 1.23881 CCDC188 - Coiled-coil domain-containing protein 188 - Homo sapiens (Human) - CCDC188 gene Taurus_UMD|evm.model.AC_000174.1.728 Q9N0E3 RTN4R_MACFA 87.315 0.995781 1.00211 RTN4R - Reticulon-4 receptor precursor - Macaca fascicularis (Crab-eating macaque) - RTN4R gene Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1 (By similarity). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition (By similarity). May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (By similarity). Interacts with OMG (By similarity). Taurus_UMD|evm.model.AC_000174.1.729 P01703 LV140_HUMAN 76.522 0.797203 1.21186 IGLV1-40 - Immunoglobulin lambda variable 1-40 precursor - Homo sapiens (Human) - IGLV1-40 gene V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.AC_000174.1.730 Q9BXQ6 T121B_HUMAN 83.209 0.992337 0.451557 TMEM121B - Transmembrane protein 121B - Homo sapiens (Human) - TMEM121B gene Taurus_UMD|evm.model.AC_000175.1.1 Q8IYA2 C144C_HUMAN 55.000 0.416544 0.547292 CCDC144CP - Putative coiled-coil domain-containing protein 144C - Homo sapiens (Human) - CCDC144CP gene Taurus_UMD|evm.model.AC_000175.1.3 Q8NGL7 OR4P4_HUMAN 71.134 0.989474 0.304487 OR4P4 - Olfactory receptor 4P4 - Homo sapiens (Human) - OR4P4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000175.1.8 P13272 UCRI_BOVIN 100.000 0.992727 1.00365 UQCRFS1 - Cytochrome b-c1 complex subunit Rieske, mitochondrial precursor - Bos taurus (Bovine) - UQCRFS1 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1 (By similarity). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity). Taurus_UMD|evm.model.AC_000175.1.9 A6NLU5 VTM2B_HUMAN 87.500 0.388664 1.73333 VSTM2B - V-set and transmembrane domain-containing protein 2B precursor - Homo sapiens (Human) - VSTM2B gene integral component of membrane Taurus_UMD|evm.model.AC_000175.1.10 A2VE70 VAC14_BOVIN 99.869 0.516216 1.89017 VAC14 - Protein VAC14 homolog - Bos taurus (Bovine) - VAC14 gene The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes (By similarity). Taurus_UMD|evm.model.AC_000175.1.11 A6QL48 IL34_BOVIN 100.000 0.991489 1.00427 IL34 - Interleukin-34 precursor - Bos taurus (Bovine) - IL34 gene Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity). Taurus_UMD|evm.model.AC_000175.1.12 Q9BQ04 RBM4B_HUMAN 56.744 0.950739 0.56546 RBM4B - RNA-binding protein 4B - Homo sapiens (Human) - RBM4B gene Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity). Taurus_UMD|evm.model.AC_000175.1.13 Q15393 SF3B3_HUMAN 100.000 0.998358 1.00082 SF3B3 - Splicing factor 3B subunit 3 - Homo sapiens (Human) - SF3B3 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). Taurus_UMD|evm.model.AC_000175.1.14 Q3MHG0 COG4_BOVIN 100.000 0.992405 1.00637 COG4 - Conserved oligomeric Golgi complex subunit 4 - Bos taurus (Bovine) - COG4 gene Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Taurus_UMD|evm.model.AC_000175.1.15 Q8N0W3 FCSK_HUMAN 87.488 0.998148 0.99631 FCSK - L-fucose kinase - Homo sapiens (Human) - FCSK gene Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides. Taurus_UMD|evm.model.AC_000175.1.16 Q16842 SIA4B_HUMAN 96.000 0.994302 1.00286 ST3GAL2 - CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 - Homo sapiens (Human) - ST3GAL2 gene A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8920913, PubMed:9266697). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8920913, PubMed:9266697, PubMed:25916169). Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8920913, PubMed:9266697). Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity). Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (By similarity). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (PubMed:12716912). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:9266697, PubMed:25916169). Taurus_UMD|evm.model.AC_000175.1.17 Q3ZBV2 DD19A_BOVIN 100.000 0.995825 1.00209 DDX19A - ATP-dependent RNA helicase DDX19A - Bos taurus (Bovine) - DDX19A gene ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. Taurus_UMD|evm.model.AC_000175.1.18 Q9UMR2 DD19B_HUMAN 98.121 0.995833 1.00209 DDX19B - ATP-dependent RNA helicase DDX19B - Homo sapiens (Human) - DDX19B gene ATP-dependent RNA helicase involved in mRNA export from the nucleus (PubMed:10428971). Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (PubMed:10428971). Taurus_UMD|evm.model.AC_000175.1.19 P49588 SYAC_HUMAN 95.455 0.997936 1.00103 AARS1 - Alanine--tRNA ligase, cytoplasmic - Homo sapiens (Human) - AARS1 gene Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438). Taurus_UMD|evm.model.AC_000175.1.21 A5D8T8 CL18A_HUMAN 90.203 0.948553 0.697309 CLEC18A - C-type lectin domain family 18 member A precursor - Homo sapiens (Human) - CLEC18A gene Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans (PubMed:26170455). Taurus_UMD|evm.model.AC_000175.1.22 Q6UXF7 CL18B_HUMAN 69.697 0.462898 0.621978 CLEC18B - C-type lectin domain family 18 member B precursor - Homo sapiens (Human) - CLEC18B gene Binds polysaccharides in a Ca(2+)-independent manner (By similarity). Taurus_UMD|evm.model.AC_000175.1.23 O46504 PDPR_BOVIN 99.772 0.997725 1.00114 PDPR - Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial precursor - Bos taurus (Bovine) - PDPR gene Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine. Taurus_UMD|evm.model.AC_000175.1.24 Q92896 GSLG1_HUMAN 98.316 0.81155 1.1162 GLG1 - Golgi apparatus protein 1 precursor - Homo sapiens (Human) - GLG1 gene Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils). Taurus_UMD|evm.model.AC_000175.1.25 Q7L5A8 FA2H_HUMAN 81.138 0.208516 4.29301 FA2H - Fatty acid 2-hydroxylase - Homo sapiens (Human) - FA2H gene Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:15337768, PubMed:15863841, PubMed:17355976, PubMed:22517924). FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (PubMed:22517924). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (By similarity). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (PubMed:17355976). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis (By similarity). Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity). Taurus_UMD|evm.model.AC_000175.1.26 Q6PJI9 WDR59_HUMAN 97.331 0.997949 1.00103 WDR59 - GATOR complex protein WDR59 - Homo sapiens (Human) - WDR59 gene As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). Taurus_UMD|evm.model.AC_000175.1.27 F1MM41 ZNRF1_BOVIN 100.000 0.991228 1.00441 ZNRF1 - E3 ubiquitin-protein ligase ZNRF1 - Bos taurus (Bovine) - ZNRF1 gene E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes degeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (By similarity). Taurus_UMD|evm.model.AC_000175.1.28 Q7TNG8 LDHD_MOUSE 84.504 0.995876 1.00207 Ldhd - Probable D-lactate dehydrogenase, mitochondrial precursor - Mus musculus (Mouse) - Ldhd gene Involved in D-lactate, but not L-lactate catabolic process. Taurus_UMD|evm.model.AC_000175.1.29 Q6P2D0 ZFP1_HUMAN 91.912 0.99511 1.00491 ZFP1 - Zinc finger protein 1 homolog - Homo sapiens (Human) - ZFP1 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.30 O46504 PDPR_BOVIN 93.333 0.270642 0.248292 PDPR - Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial precursor - Bos taurus (Bovine) - PDPR gene Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine. Taurus_UMD|evm.model.AC_000175.1.31 P00767 CTRB_BOVIN 99.592 0.924242 1.07755 Chymotrypsinogen B precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000175.1.32 P00766 CTRA_BOVIN 100.000 0.924242 1.07755 Chymotrypsinogen A precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000175.1.33 P00767 CTRB_BOVIN 68.571 0.918033 0.995918 Chymotrypsinogen B precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000175.1.34 P56945 BCAR1_HUMAN 85.731 0.973472 0.996552 BCAR1 - Breast cancer anti-estrogen resistance protein 1 - Homo sapiens (Human) - BCAR1 gene Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12832404, PubMed:12432078). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). Taurus_UMD|evm.model.AC_000175.1.35 Q8HXY9 CFDP1_BOVIN 100.000 0.993289 1.00337 CFDP1 - Craniofacial development protein 1 - Bos taurus (Bovine) - CFDP1 gene May play a role during embryogenesis. Taurus_UMD|evm.model.AC_000175.1.36 O02751 CFDP2_BOVIN 99.662 0.876855 1.13851 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000175.1.37 Q32L59 TMC5B_BOVIN 88.636 0.0677165 1.80912 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Taurus_UMD|evm.model.AC_000175.1.38 Q8WVE7 T170A_HUMAN 97.917 0.986207 1.00694 TMEM170A - Transmembrane protein 170A - Homo sapiens (Human) - TMEM170A gene Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). Taurus_UMD|evm.model.AC_000175.1.40 A7MB75 TM231_BOVIN 98.678 0.290488 2.46203 TMEM231 - Transmembrane protein 231 - Bos taurus (Bovine) - TMEM231 gene Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). Taurus_UMD|evm.model.AC_000175.1.41 P60522 GBRL2_RAT 99.145 0.686391 1.44444 Gabarapl2 - Gamma-aminobutyric acid receptor-associated protein-like 2 precursor - Rattus norvegicus (Rat) - Gabarapl2 gene Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). Taurus_UMD|evm.model.AC_000175.1.42 Q9BUB4 ADAT1_HUMAN 79.579 0.871747 1.07171 ADAT1 - tRNA-specific adenosine deaminase 1 - Homo sapiens (Human) - ADAT1 gene Specifically deaminates adenosine-37 to inosine in tRNA-Ala. Taurus_UMD|evm.model.AC_000175.1.43 Q15046 SYK_HUMAN 93.467 0.996644 0.998325 KARS1 - Lysine--tRNA ligase - Homo sapiens (Human) - KARS1 gene Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739). Taurus_UMD|evm.model.AC_000175.1.44 Q0VCT3 TE2IP_BOVIN 100.000 0.995 1.00251 TERF2IP - Telomeric repeat-binding factor 2-interacting protein 1 - Bos taurus (Bovine) - TERF2IP gene Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity). Taurus_UMD|evm.model.AC_000175.1.47 P20414 TIMP1_BOVIN 38.000 0.510989 0.879227 TIMP1 - Metalloproteinase inhibitor 1 precursor - Bos taurus (Bovine) - TIMP1 gene Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Taurus_UMD|evm.model.AC_000175.1.48 Q7L1V2 MON1B_HUMAN 88.160 0.994536 1.00366 MON1B - Vacuolar fusion protein MON1 homolog B - Homo sapiens (Human) - MON1B gene cytoplasm, Mon1-Ccz1 complex, early viral transcription, late viral transcription Taurus_UMD|evm.model.AC_000175.1.49 Q8N0S2 SYCE1_HUMAN 58.673 0.691756 0.794872 SYCE1 - Synaptonemal complex central element protein 1 - Homo sapiens (Human) - SYCE1 gene Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination. Taurus_UMD|evm.model.AC_000175.1.50 Q8TE60 ATS18_HUMAN 86.528 0.983105 0.775594 ADAMTS18 - A disintegrin and metalloproteinase with thrombospondin motifs 18 precursor - Homo sapiens (Human) - ADAMTS18 gene extracellular matrix, metalloendopeptidase activity, extracellular matrix organization, eye development, negative regulation of platelet aggregation Taurus_UMD|evm.model.AC_000175.1.52 P0C024 NUDT7_HUMAN 68.487 0.911538 1.09244 NUDT7 - Peroxisomal coenzyme A diphosphatase NUDT7 - Homo sapiens (Human) - NUDT7 gene Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. Taurus_UMD|evm.model.AC_000175.1.53 Q9HCJ6 VAT1L_HUMAN 97.375 0.995238 1.00239 VAT1L - Synaptic vesicle membrane protein VAT-1 homolog-like - Homo sapiens (Human) - VAT1L gene Taurus_UMD|evm.model.AC_000175.1.54 Q28008 CLC3A_BOVIN 100.000 0.989899 1.00508 CLEC3A - C-type lectin domain family 3 member A precursor - Bos taurus (Bovine) - CLEC3A gene Promotes cell adhesion to laminin and fibronectin. Taurus_UMD|evm.model.AC_000175.1.56 Q9NZC7 WWOX_HUMAN 95.930 0.780822 0.528986 WWOX - WW domain-containing oxidoreductase - Homo sapiens (Human) - WWOX gene Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. Taurus_UMD|evm.model.AC_000175.1.59 Q9NZC7 WWOX_HUMAN 92.857 0.641844 0.681159 WWOX - WW domain-containing oxidoreductase - Homo sapiens (Human) - WWOX gene Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. Taurus_UMD|evm.model.AC_000175.1.63 Q5R9W5 WWOX_PONAB 85.185 0.378571 0.338164 WWOX - WW domain-containing oxidoreductase - Pongo abelii (Sumatran orangutan) - WWOX gene Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (By similarity). Taurus_UMD|evm.model.AC_000175.1.68 A7Z017 MAF_BOVIN 100.000 0.639498 0.846154 MAF - Transcription factor Maf - Bos taurus (Bovine) - MAF gene Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T-helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding (By similarity). Taurus_UMD|evm.model.AC_000175.1.72 Q32P85 DLRB2_BOVIN 100.000 0.862385 1.13542 DYNLRB2 - Dynein light chain roadblock-type 2 - Bos taurus (Bovine) - DYNLRB2 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Taurus_UMD|evm.model.AC_000175.1.73 Q8N8U2 CDYL2_HUMAN 86.347 0.81571 1.3083 CDYL2 - Chromodomain Y-like protein 2 - Homo sapiens (Human) - CDYL2 gene nucleus, transcription corepressor activity Taurus_UMD|evm.model.AC_000175.1.74 Q2NKR3 COXM2_BOVIN 100.000 0.182796 3.53165 CMC2 - COX assembly mitochondrial protein 2 homolog - Bos taurus (Bovine) - CMC2 gene May be involved in cytochrome c oxidase biogenesis. Taurus_UMD|evm.model.AC_000175.1.75 Q32LL9 CENPN_BOVIN 99.705 0.994118 1.00295 CENPN - Centromere protein N - Bos taurus (Bovine) - CENPN gene Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. Taurus_UMD|evm.model.AC_000175.1.76 O43313 ATMIN_HUMAN 86.929 0.955043 1 ATMIN - ATM interactor - Homo sapiens (Human) - ATMIN gene Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. Taurus_UMD|evm.model.AC_000175.1.77 Q4R912 CP046_MACFA 62.312 0.984887 1.03655 QtsA-10979 - Uncharacterized protein C16orf46 homolog - Macaca fascicularis (Crab-eating macaque) - QtsA-10979 gene Taurus_UMD|evm.model.AC_000175.1.78 P20821 GCSH_BOVIN 100.000 0.988506 1.00578 GCSH - Glycine cleavage system H protein, mitochondrial precursor - Bos taurus (Bovine) - GCSH gene The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Taurus_UMD|evm.model.AC_000175.1.79 Q7Z442 PK1L2_HUMAN 74.661 0.990791 0.971533 PKD1L2 - Polycystic kidney disease protein 1-like 2 precursor - Homo sapiens (Human) - PKD1L2 gene May function as an ion-channel regulator. May function as a G-protein-coupled receptor. Taurus_UMD|evm.model.AC_000175.1.80 Q91XT5 BCDO1_RAT 83.647 0.968978 0.968198 Bco1 - Beta,beta-carotene 15,15'-dioxygenase - Rattus norvegicus (Rat) - Bco1 gene Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism. Taurus_UMD|evm.model.AC_000175.1.81 Q9H2C0 GAN_HUMAN 98.492 0.996656 1.00168 GAN - Gigaxonin - Homo sapiens (Human) - GAN gene Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. Taurus_UMD|evm.model.AC_000175.1.82 Q8IY22 CMIP_HUMAN 99.257 0.992614 0.875809 CMIP - C-Maf-inducing protein - Homo sapiens (Human) - CMIP gene Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. Taurus_UMD|evm.model.AC_000175.1.83 P16885 PLCG2_HUMAN 94.066 0.967816 1.03162 PLCG2 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 - Homo sapiens (Human) - PLCG2 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. Taurus_UMD|evm.model.AC_000175.1.84 Q8CIH5 PLCG2_MOUSE 90.909 0.663265 0.0774704 Plcg2 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 - Mus musculus (Mouse) - Plcg2 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. Taurus_UMD|evm.model.AC_000175.1.85 Q8CIH5 PLCG2_MOUSE 90.476 0.584906 0.0837945 Plcg2 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 - Mus musculus (Mouse) - Plcg2 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. Taurus_UMD|evm.model.AC_000175.1.86 Q32L94 D42E1_BOVIN 99.746 0.994924 1.00254 SDR42E1 - Short-chain dehydrogenase/reductase family 42E member 1 - Bos taurus (Bovine) - SDR42E1 gene oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Taurus_UMD|evm.model.AC_000175.1.87 P37059 DHB2_HUMAN 57.367 0.989091 0.710594 HSD17B2 - 17-beta-hydroxysteroid dehydrogenase type 2 - Homo sapiens (Human) - HSD17B2 gene Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH. Taurus_UMD|evm.model.AC_000175.1.88 Q99547 MPH6_HUMAN 93.750 0.987578 1.00625 MPHOSPH6 - M-phase phosphoprotein 6 - Homo sapiens (Human) - MPHOSPH6 gene RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D. Taurus_UMD|evm.model.AC_000175.1.89 P32243 OTX2_HUMAN 69.182 0.992481 0.460208 OTX2 - Homeobox protein OTX2 - Homo sapiens (Human) - OTX2 gene Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'. Taurus_UMD|evm.model.AC_000175.1.90 Q3B7N0 CAD13_BOVIN 98.893 0.81571 0.464236 CDH13 - Cadherin-13 precursor - Bos taurus (Bovine) - CDH13 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth (By similarity). Taurus_UMD|evm.model.AC_000175.1.91 Q3ZC22 HSBP1_BOVIN 88.750 0.975 1.05263 HSBP1 - Heat shock factor-binding protein 1 - Bos taurus (Bovine) - HSBP1 gene Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity). Taurus_UMD|evm.model.AC_000175.1.92 O95822 DCMC_HUMAN 84.970 0.996 1.0142 MLYCD - Malonyl-CoA decarboxylase, mitochondrial precursor - Homo sapiens (Human) - MLYCD gene Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. Taurus_UMD|evm.model.AC_000175.1.94 Q7Z6G3 NECA2_HUMAN 87.267 0.518578 1.60363 NECAB2 - N-terminal EF-hand calcium-binding protein 2 - Homo sapiens (Human) - NECAB2 gene May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. Taurus_UMD|evm.model.AC_000175.1.95 A6NNN8 S38A8_HUMAN 82.759 0.995413 1.0023 SLC38A8 - Putative sodium-coupled neutral amino acid transporter 8 - Homo sapiens (Human) - SLC38A8 gene Putative sodium-dependent amino acid/proton antiporter. Taurus_UMD|evm.model.AC_000175.1.96 Q14703 MBTP1_HUMAN 95.722 0.998101 1.00095 MBTPS1 - Membrane-bound transcription factor site-1 protease precursor - Homo sapiens (Human) - MBTPS1 gene Serine protease that cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4: known substrates are SREBF1/SREBP1, SREBF2/SREBP2, BDNF, GNPTAB, ATF6 and ATF6B (PubMed:10644685, PubMed:12782636, PubMed:21719679). Cleaves substrates after Arg-Ser-Val-Leu (SREBP2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu (PubMed:10644685, PubMed:21719679). Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12782636). Also mediates the first step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B) (PubMed:12782636). Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes (PubMed:21719679). Involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes (PubMed:21719679, PubMed:30046013). It is required for the activation of CREB3L2/BBF2H7, a transcriptional activator of MIA3/TANGO and other genes controlling mega vesicle formation (PubMed:30046013). Therefore, it plays a key role in the regulation of mega vesicle-mediated collagen trafficking (PubMed:30046013). Taurus_UMD|evm.model.AC_000175.1.97 A5PJF6 HSDL1_BOVIN 100.000 0.993958 1.00303 HSDL1 - Inactive hydroxysteroid dehydrogenase-like protein 1 - Bos taurus (Bovine) - HSDL1 gene mitochondrion Taurus_UMD|evm.model.AC_000175.1.98 Q3SYS4 DAAF1_BOVIN 99.533 0.996894 1.00156 DNAAF1 - Dynein axonemal assembly factor 1 - Bos taurus (Bovine) - DNAAF1 gene Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms (By similarity). Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (By similarity). Taurus_UMD|evm.model.AC_000175.1.99 Q15572 TAF1C_HUMAN 69.789 0.90604 1.02877 TAF1C - TATA box-binding protein-associated factor RNA polymerase I subunit C - Homo sapiens (Human) - TAF1C gene Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. Taurus_UMD|evm.model.AC_000175.1.100 Q9D5P4 ADAD2_MOUSE 76.618 0.847518 1.17992 Adad2 - Adenosine deaminase domain-containing protein 2 - Mus musculus (Mouse) - Adad2 gene cytoplasm, nucleolus, double-stranded RNA adenosine deaminase activity, double-stranded RNA binding, tRNA-specific adenosine deaminase activity, adenosine to inosine editing, RNA processing Taurus_UMD|evm.model.AC_000175.1.101 Q8TDN1 KCNG4_HUMAN 83.591 0.99604 0.973025 KCNG4 - Potassium voltage-gated channel subfamily G member 4 - Homo sapiens (Human) - KCNG4 gene Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135). Taurus_UMD|evm.model.AC_000175.1.102 O70280 WFDC1_RAT 82.979 0.665468 1.31132 Wfdc1 - WAP four-disulfide core domain protein 1 precursor - Rattus norvegicus (Rat) - Wfdc1 gene Has growth inhibitory activity. Taurus_UMD|evm.model.AC_000175.1.103 O75185 AT2C2_HUMAN 87.302 0.996832 1.00106 ATP2C2 - Calcium-transporting ATPase type 2C member 2 - Homo sapiens (Human) - ATP2C2 gene ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:15831496, PubMed:16332677, PubMed:30923126, PubMed:15677451). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:15831496, PubMed:16332677). Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus (PubMed:23840669, PubMed:20887894). Taurus_UMD|evm.model.AC_000175.1.104 Q6P9B6 MEAK7_HUMAN 72.747 0.878143 1.13377 MEAK7 - MTOR-associated protein MEAK7 - Homo sapiens (Human) - MEAK7 gene Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (PubMed:29750193). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (PubMed:29750193). Taurus_UMD|evm.model.AC_000175.1.105 Q2HJ57 COTL1_BOVIN 100.000 0.986014 1.00704 COTL1 - Coactosin-like protein - Bos taurus (Bovine) - COTL1 gene Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis (By similarity). Taurus_UMD|evm.model.AC_000175.1.106 Q3B7M1 KLH36_BOVIN 97.565 0.920245 1.05844 KLHL36 - Kelch-like protein 36 - Bos taurus (Bovine) - KLHL36 gene Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000175.1.107 A5PJS6 UBP10_BOVIN 100.000 0.931235 1.0725 USP10 - Ubiquitin carboxyl-terminal hydrolase 10 - Bos taurus (Bovine) - USP10 gene Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Deubiquitinates TBX21 leading to its stabilization. Taurus_UMD|evm.model.AC_000175.1.108 A6QLZ7 CRLD2_BOVIN 100.000 0.995976 1.00202 CRISPLD2 - Cysteine-rich secretory protein LCCL domain-containing 2 precursor - Bos taurus (Bovine) - CRISPLD2 gene Promotes matrix assembly. Taurus_UMD|evm.model.AC_000175.1.109 P83917 CBX1_MOUSE 93.701 0.617647 1.1027 Cbx1 - Chromobox protein homolog 1 - Mus musculus (Mouse) - Cbx1 gene Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Taurus_UMD|evm.model.AC_000175.1.110 Q9NXF8 ZDHC7_HUMAN 93.831 0.935976 1.06494 ZDHHC7 - Palmitoyltransferase ZDHHC7 - Homo sapiens (Human) - ZDHHC7 gene Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (PubMed:22031296, PubMed:27380321, PubMed:28196865). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways (PubMed:19001095). Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane (PubMed:25301068). In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation (PubMed:27380321). Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration (PubMed:28196865). Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane (By similarity). In brain, could also palmitoylate SNAP25 and DLG4/PSD95 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate NCDN (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity). Taurus_UMD|evm.model.AC_000175.1.113 O60268 K0513_HUMAN 89.051 0.995134 1 KIAA0513 - Uncharacterized protein KIAA0513 - Homo sapiens (Human) - KIAA0513 gene Taurus_UMD|evm.model.AC_000175.1.114 Q1RMK1 CBAR2_BOVIN 100.000 0.992754 0.958333 CIBAR2 - CBY1-interacting BAR domain-containing protein 2 - Bos taurus (Bovine) - CIBAR2 gene May play a role in ciliogenesis. In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis. Taurus_UMD|evm.model.AC_000175.1.117 Q14687 GSE1_HUMAN 86.382 0.990123 0.998357 GSE1 - Genetic suppressor element 1 - Homo sapiens (Human) - GSE1 gene Taurus_UMD|evm.model.AC_000175.1.118 Q9Y248 PSF2_HUMAN 94.595 0.989247 1.00541 GINS2 - DNA replication complex GINS protein PSF2 - Homo sapiens (Human) - GINS2 gene The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. Taurus_UMD|evm.model.AC_000175.1.119 Q96GX8 CP074_HUMAN 68.675 0.40099 2.65789 C16orf74 - Uncharacterized protein C16orf74 - Homo sapiens (Human) - C16orf74 gene Taurus_UMD|evm.model.AC_000175.1.120 Q32KL5 EMC8_BOVIN 99.524 0.990521 1.00476 EMC8 - ER membrane protein complex subunit 8 - Bos taurus (Bovine) - EMC8 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Taurus_UMD|evm.model.AC_000175.1.121 P00423 COX41_BOVIN 100.000 0.988235 1.00592 COX4I1 - Cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor - Bos taurus (Bovine) - COX4I1 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000175.1.122 Q02556 IRF8_HUMAN 90.141 0.979263 1.01878 IRF8 - Interferon regulatory factor 8 - Homo sapiens (Human) - IRF8 gene Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed:25122610). Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells (PubMed:29434592). Taurus_UMD|evm.model.AC_000175.1.125 Q12946 FOXF1_HUMAN 96.073 0.994778 1.01055 FOXF1 - Forkhead box protein F1 - Homo sapiens (Human) - FOXF1 gene Probable transcription activator for a number of lung-specific genes. Taurus_UMD|evm.model.AC_000175.1.126 Q2KI24 MTHSD_BOVIN 92.895 0.994751 1.00263 MTHFSD - Methenyltetrahydrofolate synthase domain-containing protein - Bos taurus (Bovine) - MTHFSD gene cytoplasm Taurus_UMD|evm.model.AC_000175.1.127 Q99958 FOXC2_HUMAN 96.414 0.996024 1.00399 FOXC2 - Forkhead box protein C2 - Homo sapiens (Human) - FOXC2 gene Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. Taurus_UMD|evm.model.AC_000175.1.128 Q12952 FOXL1_HUMAN 83.526 0.994236 1.0058 FOXL1 - Forkhead box protein L1 - Homo sapiens (Human) - FOXL1 gene Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity). Taurus_UMD|evm.model.AC_000175.1.134 Q9H693 CP095_HUMAN 56.338 0.301724 1.46835 C16orf95 - Uncharacterized protein C16orf95 - Homo sapiens (Human) - C16orf95 gene Taurus_UMD|evm.model.AC_000175.1.135 Q5XUX0 FBX31_HUMAN 81.950 0.928144 0.929499 FBXO31 - F-box only protein 31 - Homo sapiens (Human) - FBXO31 gene Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. Taurus_UMD|evm.model.AC_000175.1.136 O41515 MLP3B_BOVIN 100.000 0.984127 1.008 MAP1LC3B - Microtubule-associated proteins 1A/1B light chain 3B precursor - Bos taurus (Bovine) - MAP1LC3B gene Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Taurus_UMD|evm.model.AC_000175.1.137 Q8WYQ9 ZCH14_HUMAN 85.430 0.997888 0.997893 ZCCHC14 - Zinc finger CCHC domain-containing protein 14 - Homo sapiens (Human) - ZCCHC14 gene Taurus_UMD|evm.model.AC_000175.1.139 Q9ET77 JPH3_MOUSE 91.114 0.997351 1.01478 Jph3 - Junctophilin-3 - Mus musculus (Mouse) - Jph3 gene Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory. Taurus_UMD|evm.model.AC_000175.1.140 Q5R8W1 KLDC4_PONAB 83.579 0.795302 1.14176 KLHDC4 - Kelch domain-containing protein 4 - Pongo abelii (Sumatran orangutan) - KLHDC4 gene Taurus_UMD|evm.model.AC_000175.1.141 Q01650 LAT1_HUMAN 91.373 0.90161 1.10256 SLC7A5 - Large neutral amino acids transporter small subunit 1 - Homo sapiens (Human) - SLC7A5 gene The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:10049700, PubMed:11557028, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591). Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Can mediate the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859). When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744). Taurus_UMD|evm.model.AC_000175.1.142 P35218 CAH5A_HUMAN 73.973 0.751938 1.26885 CA5A - Carbonic anhydrase 5A, mitochondrial precursor - Homo sapiens (Human) - CA5A gene Reversible hydration of carbon dioxide. Low activity. Taurus_UMD|evm.model.AC_000175.1.144 Q0VCW3 BANP_BOVIN 97.550 0.935282 0.952286 BANP - Protein BANP - Bos taurus (Bovine) - BANP gene Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest (By similarity). Taurus_UMD|evm.model.AC_000175.1.145 Q0VCW3 BANP_BOVIN 100.000 0.259459 0.367793 BANP - Protein BANP - Bos taurus (Bovine) - BANP gene Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest (By similarity). Taurus_UMD|evm.model.AC_000175.1.150 Q96JG9 ZN469_HUMAN 57.225 0.433104 0.85121 ZNF469 - Zinc finger protein 469 - Homo sapiens (Human) - ZNF469 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.151 Q8CCH7 FOG2_MOUSE 75.758 0.0307692 0.903562 Zfpm2 - Zinc finger protein ZFPM2 - Mus musculus (Mouse) - Zfpm2 gene Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2. Taurus_UMD|evm.model.AC_000175.1.152 P34981 TRFR_HUMAN 51.105 0.866162 0.994975 TRHR - Thyrotropin-releasing hormone receptor - Homo sapiens (Human) - TRHR gene Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. Taurus_UMD|evm.model.AC_000175.1.153 Q86VM9 ZCH18_HUMAN 83.451 0.474138 1.21721 ZC3H18 - Zinc finger CCCH domain-containing protein 18 - Homo sapiens (Human) - ZC3H18 gene nuclear speck, protein-containing complex, ribonucleoprotein complex, mRNA cap binding complex binding, protein-macromolecule adaptor activity, RNA binding, RNA destabilization Taurus_UMD|evm.model.AC_000175.1.154 O46521 CY24A_BOVIN 100.000 0.989583 1.00524 CYBA - Cytochrome b-245 light chain - Bos taurus (Bovine) - CYBA gene Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Taurus_UMD|evm.model.AC_000175.1.155 Q0P570 MVD1_BOVIN 100.000 0.995012 1.0025 MVD - Diphosphomevalonate decarboxylase - Bos taurus (Bovine) - MVD gene Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. Taurus_UMD|evm.model.AC_000175.1.156 O95863 SNAI1_HUMAN 78.571 0.380137 1.10606 SNAI1 - Zinc finger protein SNAI1 - Homo sapiens (Human) - SNAI1 gene Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. Taurus_UMD|evm.model.AC_000175.1.157 Q96A37 RN166_HUMAN 94.515 0.991597 1.00422 RNF166 - E3 ubiquitin-protein ligase RNF166 - Homo sapiens (Human) - RNF166 gene E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates (PubMed:27880896). In turn, participates in different biological processes including interferon production or autophagy (PubMed:26456228, PubMed:27880896). Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 (PubMed:26456228). Plays also a role in the early recruitment of autophagy adapters to bacteria (PubMed:27880896). Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896). Taurus_UMD|evm.model.AC_000175.1.158 Q3SZG9 CTU2_BOVIN 100.000 0.996016 1.002 CTU2 - Cytoplasmic tRNA 2-thiolation protein 2 - Bos taurus (Bovine) - CTU2 gene Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Taurus_UMD|evm.model.AC_000175.1.159 Q92508 PIEZ1_HUMAN 81.187 0.989899 0.942483 PIEZO1 - Piezo-type mechanosensitive ion channel component 1 - Homo sapiens (Human) - PIEZO1 gene Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation. Taurus_UMD|evm.model.AC_000175.1.160 Q0KL00 PIEZ1_RAT 70.755 0.826772 0.0500986 Piezo1 - Piezo-type mechanosensitive ion channel component 1 - Rattus norvegicus (Rat) - Piezo1 gene Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology. Acts as sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation. Taurus_UMD|evm.model.AC_000175.1.161 Q0KL00 PIEZ1_RAT 86.538 0.447368 0.0449704 Piezo1 - Piezo-type mechanosensitive ion channel component 1 - Rattus norvegicus (Rat) - Piezo1 gene Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology. Acts as sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation. Taurus_UMD|evm.model.AC_000175.1.162 Q9H211 CDT1_HUMAN 76.311 0.99639 1.01465 CDT1 - DNA replication factor Cdt1 - Homo sapiens (Human) - CDT1 gene Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). Taurus_UMD|evm.model.AC_000175.1.163 Q56JW4 APT_BOVIN 100.000 0.98895 1.00556 APRT - Adenine phosphoribosyltransferase - Bos taurus (Bovine) - APRT gene Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Taurus_UMD|evm.model.AC_000175.1.164 Q8WNQ7 GALNS_PIG 91.571 0.996176 1.00192 GALNS - N-acetylgalactosamine-6-sulfatase precursor - Sus scrofa (Pig) - GALNS gene Taurus_UMD|evm.model.AC_000175.1.165 A6H7F7 TPC2L_BOVIN 100.000 0.977099 0.942446 TRAPPC2L - Trafficking protein particle complex subunit 2-like protein - Bos taurus (Bovine) - TRAPPC2L gene May play a role in vesicular transport from endoplasmic reticulum to Golgi. Taurus_UMD|evm.model.AC_000175.1.166 Q7ZXB8 PAB2B_XENLA 70.833 0.318792 1.01017 pabpn1-b - Polyadenylate-binding protein 2-B - Xenopus laevis (African clawed frog) - pabpn1-b gene Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. Taurus_UMD|evm.model.AC_000175.1.167 O54972 MTG16_MOUSE 88.360 0.977431 0.929032 Cbfa2t3 - Protein CBFA2T3 - Mus musculus (Mouse) - Cbfa2t3 gene Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (By similarity). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:16407974). Plays a role in granulocyte differentiation (PubMed:15231665). Taurus_UMD|evm.model.AC_000175.1.169 Q58DN7 ACSF3_BOVIN 100.000 0.996593 1.00171 ACSF3 - Malonate--CoA ligase ACSF3, mitochondrial precursor - Bos taurus (Bovine) - ACSF3 gene Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates. Taurus_UMD|evm.model.AC_000175.1.170 P55291 CAD15_HUMAN 85.751 0.997455 0.965602 CDH15 - Cadherin-15 precursor - Homo sapiens (Human) - CDH15 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation. Taurus_UMD|evm.model.AC_000175.1.171 A6NKX4 S22AV_HUMAN 71.507 0.974074 0.971223 SLC22A31 - Putative solute carrier family 22 member 31 - Homo sapiens (Human) - SLC22A31 gene Organic anion transporter that mediates the uptake of ions. Taurus_UMD|evm.model.AC_000175.1.173 Q6UB99 ANR11_HUMAN 76.291 0.999231 0.976342 ANKRD11 - Ankyrin repeat domain-containing protein 11 - Homo sapiens (Human) - ANKRD11 gene Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). Taurus_UMD|evm.model.AC_000175.1.175 Q9UQ90 SPG7_HUMAN 89.410 0.955128 0.981132 SPG7 - Paraplegin precursor - Homo sapiens (Human) - SPG7 gene ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (PubMed:26387735). Taurus_UMD|evm.model.AC_000175.1.176 Q56JZ1 RL13_BOVIN 100.000 0.990566 1.00474 RPL13 - 60S ribosomal protein L13 - Bos taurus (Bovine) - RPL13 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the LSU, it is probably required for its formation and the maturation of rRNAs. Plays a role in bone development. Taurus_UMD|evm.model.AC_000175.1.177 Q9UBL6 CPNE7_HUMAN 90.951 0.781818 0.868878 CPNE7 - Copine-7 - Homo sapiens (Human) - CPNE7 gene Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Taurus_UMD|evm.model.AC_000175.1.178 Q3SZM7 DPEP1_BOVIN 100.000 0.855649 1.16585 DPEP1 - Dipeptidase 1 precursor - Bos taurus (Bovine) - DPEP1 gene Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics. Taurus_UMD|evm.model.AC_000175.1.179 Q5R605 CHM1A_PONAB 97.959 0.989848 1.0051 CHMP1A - Charged multivesicular body protein 1a - Pongo abelii (Sumatran orangutan) - CHMP1A gene Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing (By similarity). Taurus_UMD|evm.model.AC_000175.1.180 Q8C624 SPT33_MOUSE 47.101 0.985401 1.03788 Spata33 - Spermatogenesis-associated protein 33 - Mus musculus (Mouse) - Spata33 gene cytoplasm, nucleus Taurus_UMD|evm.model.AC_000175.1.181 Q2TBL8 CDK10_BOVIN 100.000 0.994475 1.00277 CDK10 - Cyclin-dependent kinase 10 - Bos taurus (Bovine) - CDK10 gene Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling. Taurus_UMD|evm.model.AC_000175.1.182 Q0IIA6 SPA2L_BOVIN 100.000 0.995122 1.00244 SPATA2L - Spermatogenesis-associated protein 2-like protein - Bos taurus (Bovine) - SPATA2L gene cytoplasm Taurus_UMD|evm.model.AC_000175.1.183 Q9Y2B5 VP9D1_HUMAN 80.462 0.99685 1.00634 VPS9D1 - VPS9 domain-containing protein 1 - Homo sapiens (Human) - VPS9D1 gene identical protein binding, transporter activity, ATP synthesis coupled proton transport Taurus_UMD|evm.model.AC_000175.1.184 Q8N554 ZN276_HUMAN 78.675 0.996689 0.983713 ZNF276 - Zinc finger protein 276 - Homo sapiens (Human) - ZNF276 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.185 O15360 FANCA_HUMAN 66.736 0.992963 0.976632 FANCA - Fanconi anemia group A protein - Homo sapiens (Human) - FANCA gene DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Taurus_UMD|evm.model.AC_000175.1.186 Q8K1S6 SPIR2_MOUSE 81.107 0.770149 0.933148 Spire2 - Protein spire homolog 2 - Mus musculus (Mouse) - Spire2 gene Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703, PubMed:21983562). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:21983562). Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (By similarity). Taurus_UMD|evm.model.AC_000175.1.187 Q8WWL2 SPIR2_HUMAN 86.772 0.770492 0.341737 SPIRE2 - Protein spire homolog 2 - Homo sapiens (Human) - SPIRE2 gene Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Taurus_UMD|evm.model.AC_000175.1.188 Q8R3L2 TCF25_MOUSE 81.906 0.971564 0.936391 Tcf25 - Transcription factor 25 - Mus musculus (Mouse) - Tcf25 gene May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development (By similarity). Taurus_UMD|evm.model.AC_000175.1.189 P47798 MSHR_BOVIN 100.000 0.993711 1.00315 MC1R - Melanocyte-stimulating hormone receptor - Bos taurus (Bovine) - MC1R gene Receptor for MSH (alpha, beta) and ACTH (PubMed:8034052). Does not seem to be active with gamma-MSH (PubMed:8034052). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:8034052). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (By similarity). Taurus_UMD|evm.model.AC_000175.1.190 Q60HC2 TBB3_MACFA 100.000 0.995565 1.00222 TUBB3 - Tubulin beta-3 chain - Macaca fascicularis (Crab-eating macaque) - TUBB3 gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and maintenance (By similarity). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Plays a role in dorsal root ganglion axon projection towards the spinal cord (By similarity). Taurus_UMD|evm.model.AC_000175.1.191 A5PJM7 DEFI8_BOVIN 94.725 0.995604 1.0179 DEF8 - Differentially expressed in FDCP 8 homolog - Bos taurus (Bovine) - DEF8 gene Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. Taurus_UMD|evm.model.AC_000175.1.192 B2RD01 CENP1_HUMAN 77.941 0.348958 1.02674 CENPBD1 - CENPB DNA-binding domain-containing protein 1 - Homo sapiens (Human) - CENPBD1 gene Taurus_UMD|evm.model.AC_000175.1.193 Q920A7 AFG31_MOUSE 81.234 0.972938 0.983523 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Taurus_UMD|evm.model.AC_000175.1.194 A6H7B4 DBND1_BOVIN 100.000 0.727723 1.27848 DBNDD1 - Dysbindin domain-containing protein 1 - Bos taurus (Bovine) - DBNDD1 gene negative regulation of protein kinase activity Taurus_UMD|evm.model.AC_000175.1.195 A5D7M3 DRC4_BOVIN 99.582 0.924419 1.0795 GAS8 - Dynein regulatory complex subunit 4 - Bos taurus (Bovine) - GAS8 gene Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner. Taurus_UMD|evm.model.AC_000175.1.196 Q9CRB3 HIUH_MOUSE 79.661 0.823944 1.20339 Urah - 5-hydroxyisourate hydrolase - Mus musculus (Mouse) - Urah gene Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). Taurus_UMD|evm.model.AC_000175.1.197 Q8NEM2 SHCBP_HUMAN 89.763 0.997037 1.00446 SHCBP1 - SHC SH2 domain-binding protein 1 - Homo sapiens (Human) - SHCBP1 gene May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. Taurus_UMD|evm.model.AC_000175.1.198 Q3SZV2 KXDL1_BOVIN 98.295 0.988701 1.00568 KXD1 - KxDL motif-containing protein 1 - Bos taurus (Bovine) - KXD1 gene As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May also be involved in the biogenesis of lysosome-related organelles such as melanosomes. Taurus_UMD|evm.model.AC_000175.1.199 Q2HJG5 VPS35_BOVIN 100.000 0.997491 1.00126 VPS35 - Vacuolar protein sorting-associated protein 35 - Bos taurus (Bovine) - VPS35 gene Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for endosomal localization of WASHC2. Mediates the association of the CSC with the WASH complex via WASHC2. Required for the endosomal localization of TBC1D5 (By similarity). Taurus_UMD|evm.model.AC_000175.1.200 Q2HJF3 ORC6_BOVIN 100.000 0.992095 1.00397 ORC6 - Origin recognition complex subunit 6 - Bos taurus (Bovine) - ORC6 gene Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Taurus_UMD|evm.model.AC_000175.1.201 Q32MK0 MYLK3_HUMAN 73.138 0.997459 0.960928 MYLK3 - Myosin light chain kinase 3 - Homo sapiens (Human) - MYLK3 gene Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). Taurus_UMD|evm.model.AC_000175.1.203 Q6PH81 CP087_HUMAN 77.273 0.983333 0.779221 C16orf87 - UPF0547 protein C16orf87 - Homo sapiens (Human) - C16orf87 gene Taurus_UMD|evm.model.AC_000175.1.204 Q5EA40 BCAT2_BOVIN 61.250 0.766467 0.424936 BCAT2 - Branched-chain-amino-acid aminotransferase, mitochondrial precursor - Bos taurus (Bovine) - BCAT2 gene Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). Taurus_UMD|evm.model.AC_000175.1.205 Q8TD30 ALAT2_HUMAN 96.558 0.996183 1.00191 GPT2 - Alanine aminotransferase 2 - Homo sapiens (Human) - GPT2 gene Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Taurus_UMD|evm.model.AC_000175.1.206 Q2HJ94 DNJA2_BOVIN 100.000 0.995157 1.00243 DNAJA2 - DnaJ homolog subfamily A member 2 precursor - Bos taurus (Bovine) - DNAJA2 gene Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Taurus_UMD|evm.model.AC_000175.1.207 P24049 RL17_RAT 80.978 0.987013 0.836957 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000175.1.208 Q8NC67 NETO2_HUMAN 97.143 0.996198 1.0019 NETO2 - Neuropilin and tolloid-like protein 2 precursor - Homo sapiens (Human) - NETO2 gene Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity). Taurus_UMD|evm.model.AC_000175.1.209 Q95KC8 TIP_MACFA 96.141 0.506536 1.96785 ITFG1 - T-cell immunomodulatory protein - Macaca fascicularis (Crab-eating macaque) - ITFG1 gene Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity). Taurus_UMD|evm.model.AC_000175.1.210 P12798 KPBB_RABIT 87.477 0.984157 0.981702 PHKB - Phosphorylase b kinase regulatory subunit beta - Oryctolagus cuniculus (Rabbit) - PHKB gene Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation. Taurus_UMD|evm.model.AC_000175.1.211 Q5RFL9 NONO_PONAB 94.512 0.733032 0.469214 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Taurus_UMD|evm.model.AC_000175.1.212 Q96J65 MRP9_HUMAN 87.144 0.997076 1.00662 ABCC12 - ATP-binding cassette sub-family C member 12 - Homo sapiens (Human) - ABCC12 gene Probable transporter, its substrate specificity is unknown. Taurus_UMD|evm.model.AC_000175.1.213 Q96J66 MRP8_HUMAN 76.052 0.239689 0.929812 ABCC11 - ATP-binding cassette sub-family C member 11 - Homo sapiens (Human) - ABCC11 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides (PubMed:12764137, PubMed:15537867). Stimulates the ATP-dependent uptake of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:25896536). Enhances also the cellular extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867). Confers resistance to anticancer drugs, such as 5-fluorouracil (5-FU) and methotrexate (PubMed:25896536, PubMed:15537867, PubMed:12764137). Probably functions to secrete earwax (PubMed:16444273, PubMed:19383836). Required for the secretion of components contributing to axillary odor formation (PubMed:19710689, PubMed:12764137, PubMed:15537867, PubMed:16444273, PubMed:19383836, PubMed:25896536). Taurus_UMD|evm.model.AC_000175.1.214 Q3SX23 LONP2_BOVIN 100.000 0.997655 1.00117 LONP2 - Lon protease homolog 2, peroxisomal - Bos taurus (Bovine) - LONP2 gene ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. Taurus_UMD|evm.model.AC_000175.1.215 Q8IUQ4 SIAH1_HUMAN 99.645 0.894904 1.11348 SIAH1 - E3 ubiquitin-protein ligase SIAH1 - Homo sapiens (Human) - SIAH1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP (PubMed:10747903, PubMed:11146551, PubMed:11389839, PubMed:11389840, PubMed:11483517, PubMed:11483518, PubMed:11752454, PubMed:12072443). Confers constitutive instability to HIPK2 through proteasomal degradation (PubMed:18536714). It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Has some overlapping function with SIAH2 (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Induces apoptosis in cooperation with PEG3 (By similarity). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus (By similarity). GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Taurus_UMD|evm.model.AC_000175.1.217 O75113 N4BP1_HUMAN 88.176 0.97046 1.02009 N4BP1 - NEDD4-binding protein 1 - Homo sapiens (Human) - N4BP1 gene Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). Taurus_UMD|evm.model.AC_000175.1.219 P63182 CBLN1_RAT 100.000 0.989691 1.00518 Cbln1 - Cerebellin-1 precursor - Rattus norvegicus (Rat) - Cbln1 gene Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2. NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (By similarity). Essential for long-term maintenance but not establishment of excitatory synapses (By similarity). Inhibits the formation and function of inhibitory GABAergic synapses in cerebellar Purkinje cells (By similarity). Taurus_UMD|evm.model.AC_000175.1.220 Q8WTQ4 CP078_HUMAN 60.289 0.992754 1.04151 C16orf78 - Uncharacterized protein C16orf78 - Homo sapiens (Human) - C16orf78 gene nucleus Taurus_UMD|evm.model.AC_000175.1.221 Q2M1K9 ZN423_HUMAN 98.594 0.989172 1.00701 ZNF423 - Zinc finger protein 423 - Homo sapiens (Human) - ZNF423 gene Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. Taurus_UMD|evm.model.AC_000175.1.222 Q6A058 ARMX2_MOUSE 79.100 0.654661 0.602041 Armcx2 - Armadillo repeat-containing X-linked protein 2 - Mus musculus (Mouse) - Armcx2 gene May regulate the dynamics and distribution of mitochondria in neural cells. Taurus_UMD|evm.model.AC_000175.1.224 Q5R7J7 NEPR1_PONAB 100.000 0.984127 1.008 CNEP1R1 - Nuclear envelope phosphatase-regulatory subunit 1 - Pongo abelii (Sumatran orangutan) - CNEP1R1 gene Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol (By similarity). Taurus_UMD|evm.model.AC_000175.1.225 Q7Z4Q2 HEAT3_HUMAN 89.706 0.997059 1 HEATR3 - HEAT repeat-containing protein 3 - Homo sapiens (Human) - HEATR3 gene unfolded protein binding, protein import into nucleus, ribosomal large subunit biogenesis Taurus_UMD|evm.model.AC_000175.1.226 Q68ED3 PAPD5_MOUSE 87.218 0.985075 0.21169 Tent4b - Terminal nucleotidyltransferase 4B - Mus musculus (Mouse) - Tent4b gene Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (By similarity). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (By similarity). Taurus_UMD|evm.model.AC_000175.1.227 Q68ED3 PAPD5_MOUSE 95.706 0.995918 0.774092 Tent4b - Terminal nucleotidyltransferase 4B - Mus musculus (Mouse) - Tent4b gene Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (By similarity). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (By similarity). Taurus_UMD|evm.model.AC_000175.1.228 Q29450 ADCY7_BOVIN 98.888 0.980874 1.01855 ADCY7 - Adenylate cyclase type 7 - Bos taurus (Bovine) - ADCY7 gene Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors. Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (By similarity). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (By similarity). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity). Taurus_UMD|evm.model.AC_000175.1.229 Q9NPI1 BRD7_HUMAN 92.154 0.995399 1.00154 BRD7 - Bromodomain-containing protein 7 - Homo sapiens (Human) - BRD7 gene Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. Taurus_UMD|evm.model.AC_000175.1.230 Q969G9 NKD1_HUMAN 89.378 0.871041 0.940426 NKD1 - Protein naked cuticle homolog 1 - Homo sapiens (Human) - NKD1 gene Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Taurus_UMD|evm.model.AC_000175.1.231 Q2T9W1 SNX20_BOVIN 100.000 0.992395 0.832278 SNX20 - Sorting nexin-20 - Bos taurus (Bovine) - SNX20 gene May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion. Taurus_UMD|evm.model.AC_000175.1.232 Q6E804 NOD2_BOVIN 100.000 0.998028 1.00099 NOD2 - Nucleotide-binding oligomerization domain-containing protein 2 - Bos taurus (Bovine) - NOD2 gene Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages. Component of an autophagy-mediated antibacterial pathway together with ATG16L1. Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon. Taurus_UMD|evm.model.AC_000175.1.233 Q1RMU2 CYLD_BOVIN 100.000 0.997904 1.00105 CYLD - Ubiquitin carboxyl-terminal hydrolase CYLD - Bos taurus (Bovine) - CYLD gene Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (By similarity). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis. Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins. Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (By similarity). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (By similarity). Taurus_UMD|evm.model.AC_000175.1.234 Q9NSC2 SALL1_HUMAN 92.151 0.998481 0.994713 SALL1 - Sal-like protein 1 - Homo sapiens (Human) - SALL1 gene Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development. Taurus_UMD|evm.model.AC_000175.1.235 Q9C056 NKX62_HUMAN 92.973 0.686567 0.967509 NKX6-2 - Homeobox protein Nkx-6.2 - Homo sapiens (Human) - NKX6-2 gene Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'-(A/T)TTAATGA-3'. In oligodendrocytes, binds to MBP and PLP1 promoter regions. Taurus_UMD|evm.model.AC_000175.1.236 O15405 TOX3_HUMAN 94.667 0.625 0.819444 TOX3 - TOX high mobility group box family member 3 - Homo sapiens (Human) - TOX3 gene Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. Taurus_UMD|evm.model.AC_000175.1.238 Q3L8U1 CHD9_HUMAN 95.657 0.99931 1.00104 CHD9 - Chromodomain-helicase-DNA-binding protein 9 - Homo sapiens (Human) - CHD9 gene Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). Taurus_UMD|evm.model.AC_000175.1.239 Q08999 RBL2_HUMAN 96.053 0.998247 1.00176 RBL2 - Retinoblastoma-like protein 2 - Homo sapiens (Human) - RBL2 gene Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. Taurus_UMD|evm.model.AC_000175.1.240 Q5RE48 AKTIP_PONAB 98.294 0.993197 1.00341 AKTIP - AKT-interacting protein - Pongo abelii (Sumatran orangutan) - AKTIP gene Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. Taurus_UMD|evm.model.AC_000175.1.242 Q68CZ1 FTM_HUMAN 87.472 0.998426 0.96654 RPGRIP1L - Protein fantom - Homo sapiens (Human) - RPGRIP1L gene Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (PubMed:19464661). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis (By similarity). Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (PubMed:19464661). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins (By similarity). Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2 (By similarity). Taurus_UMD|evm.model.AC_000175.1.245 P78415 IRX3_HUMAN 90.079 0.996024 1.00399 IRX3 - Iroquois-class homeodomain protein IRX-3 - Homo sapiens (Human) - IRX3 gene Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. Taurus_UMD|evm.model.AC_000175.1.248 P78411 IRX5_HUMAN 98.344 0.995868 1.00207 IRX5 - Iroquois-class homeodomain protein IRX-5 - Homo sapiens (Human) - IRX5 gene Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. Taurus_UMD|evm.model.AC_000175.1.250 P78412 IRX6_HUMAN 83.259 0.995516 1 IRX6 - Iroquois-class homeodomain protein IRX-6 - Homo sapiens (Human) - IRX6 gene chromatin, nucleus, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cell development, neuron differentiation, positive regulation of transcription, DNA-templated, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000175.1.251 Q9GLE5 MMP2_BOVIN 99.395 0.996979 1.00151 MMP2 - 72 kDa type IV collagenase precursor - Bos taurus (Bovine) - MMP2 gene Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity). Taurus_UMD|evm.model.AC_000175.1.252 Q7L5N7 PCAT2_HUMAN 83.088 0.996094 0.941176 LPCAT2 - Lysophosphatidylcholine acyltransferase 2 - Homo sapiens (Human) - LPCAT2 gene Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:20363836, PubMed:21498505). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:20363836). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). Under resting conditions, acyltransferase activity is preferred (By similarity). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198). Taurus_UMD|evm.model.AC_000175.1.253 P51143 SC6A2_BOVIN 99.837 0.996753 1.00163 SLC6A2 - Sodium-dependent noradrenaline transporter - Bos taurus (Bovine) - SLC6A2 gene Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. Taurus_UMD|evm.model.AC_000175.1.254 Q56JZ1 RL13_BOVIN 92.417 0.990521 1 RPL13 - 60S ribosomal protein L13 - Bos taurus (Bovine) - RPL13 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the LSU, it is probably required for its formation and the maturation of rRNAs. Plays a role in bone development. Taurus_UMD|evm.model.AC_000175.1.255 Q29550 EST1_PIG 81.625 0.996473 1.00177 Liver carboxylesterase precursor - Sus scrofa (Pig) Taurus_UMD|evm.model.AC_000175.1.256 Q29550 EST1_PIG 79.859 0.996473 1.00177 Liver carboxylesterase precursor - Sus scrofa (Pig) Taurus_UMD|evm.model.AC_000175.1.260 P37359 MT3_BOVIN 100.000 0.397059 1 MT3 - Metallothionein-3 - Bos taurus (Bovine) - MT3 gene Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium. Taurus_UMD|evm.model.AC_000175.1.261 Q9BXC9 BBS2_HUMAN 91.678 0.99723 1.00139 BBS2 - Bardet-Biedl syndrome 2 protein - Homo sapiens (Human) - BBS2 gene The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Taurus_UMD|evm.model.AC_000175.1.262 Q3MI03 OGFD1_BOVIN 100.000 0.996317 1.00185 OGFOD1 - Prolyl 3-hydroxylase OGFOD1 - Bos taurus (Bovine) - OGFOD1 gene Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation. Taurus_UMD|evm.model.AC_000175.1.263 Q5RAI8 CPSF5_PONAB 100.000 0.729032 1.36564 NUDT21 - Cleavage and polyadenylation specificity factor subunit 5 - Pongo abelii (Sumatran orangutan) - NUDT21 gene Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7. Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function. Binds to chromatin. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. Taurus_UMD|evm.model.AC_000175.1.264 Q9UKV5 AMFR_HUMAN 95.341 0.945671 0.916019 AMFR - E3 ubiquitin-protein ligase AMFR - Homo sapiens (Human) - AMFR gene E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:10456327, PubMed:11724934, PubMed:12670940, PubMed:19103148, PubMed:24424410, PubMed:28604676). Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:10456327, PubMed:11724934, PubMed:19103148, PubMed:24424410). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:16168377, PubMed:22143767). In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:16168377, PubMed:22143767, PubMed:23223569). In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (PubMed:28604676). Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (PubMed:17043353). Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (PubMed:31953408). Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (PubMed:21636303). Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (PubMed:21636303). Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:10456327). In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). Taurus_UMD|evm.model.AC_000175.1.265 P08239 GNAO_BOVIN 100.000 0.982143 0.316384 GNAO1 - Guanine nucleotide-binding protein G(o) subunit alpha - Bos taurus (Bovine) - GNAO1 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 (By similarity). Taurus_UMD|evm.model.AC_000175.1.266 P09471 GNAO_HUMAN 94.350 0.994366 1.00282 GNAO1 - Guanine nucleotide-binding protein G(o) subunit alpha - Homo sapiens (Human) - GNAO1 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. Taurus_UMD|evm.model.AC_000175.1.267 Q3T930 EST5A_SHEEP 95.276 0.758483 1.31496 CES5A - Carboxylesterase 5A - Ovis aries (Sheep) - CES5A gene Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Taurus_UMD|evm.model.AC_000175.1.268 Q29550 EST1_PIG 78.445 0.996466 1 Liver carboxylesterase precursor - Sus scrofa (Pig) Taurus_UMD|evm.model.AC_000175.1.269 Q28165 PABP2_BOVIN 98.315 0.988827 0.584967 PABPN1 - Polyadenylate-binding protein 2 - Bos taurus (Bovine) - PABPN1 gene Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (PubMed:7479061, PubMed:10481015). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (PubMed:12637556). Increases the affinity of poly(A) polymerase for RNA (PubMed:12637556, PubMed:12853485). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (By similarity). Binds to poly(A) and to poly(G) with high affinity (PubMed:7479061, PubMed:12637556). May protect the poly(A) tail from degradation (PubMed:7479061). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (By similarity). Taurus_UMD|evm.model.AC_000175.1.270 A5PJZ5 NUP93_BOVIN 100.000 0.887202 1.12576 NUP93 - Nuclear pore complex protein Nup93 - Bos taurus (Bovine) - NUP93 gene Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling. Taurus_UMD|evm.model.AC_000175.1.271 P55017 S12A3_HUMAN 92.233 0.99806 1.00979 SLC12A3 - Solute carrier family 12 member 3 - Homo sapiens (Human) - SLC12A3 gene Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (PubMed:21613606, PubMed:22009145). Receptor for the proinflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1 (By similarity). Taurus_UMD|evm.model.AC_000175.1.273 Q15011 HERP1_HUMAN 88.660 0.992188 0.982097 HERPUD1 - Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein - Homo sapiens (Human) - HERPUD1 gene Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16289116, PubMed:28827405). Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982). Taurus_UMD|evm.model.AC_000175.1.275 Q86WI3 NLRC5_HUMAN 72.267 0.998929 1.00107 NLRC5 - Protein NLRC5 - Homo sapiens (Human) - NLRC5 gene Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. Taurus_UMD|evm.model.AC_000175.1.276 Q96FN4 CPNE2_HUMAN 96.715 0.949653 1.05109 CPNE2 - Copine-2 - Homo sapiens (Human) - CPNE2 gene Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties. Taurus_UMD|evm.model.AC_000175.1.277 Q9GZU8 PIP30_HUMAN 94.094 0.992063 0.992126 PSME3IP1 - PSME3-interacting protein - Homo sapiens (Human) - PSME3IP1 gene Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus. Taurus_UMD|evm.model.AC_000175.1.278 Q95LP3 RSPRY_MACFA 97.049 0.996534 1.00174 RSPRY1 - RING finger and SPRY domain-containing protein 1 precursor - Macaca fascicularis (Crab-eating macaque) - RSPRY1 gene Taurus_UMD|evm.model.AC_000175.1.279 Q32PC9 AR2BP_BOVIN 100.000 0.987805 1.00613 ARL2BP - ADP-ribosylation factor-like protein 2-binding protein - Bos taurus (Bovine) - ARL2BP gene Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity). Taurus_UMD|evm.model.AC_000175.1.280 A6H7B0 PLLP_BOVIN 100.000 0.814371 0.917582 PLLP - Plasmolipin - Bos taurus (Bovine) - PLLP gene Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity). Taurus_UMD|evm.model.AC_000175.1.281 A6H7B0 PLLP_BOVIN 100.000 0.294574 0.708791 PLLP - Plasmolipin - Bos taurus (Bovine) - PLLP gene Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity). Taurus_UMD|evm.model.AC_000175.1.282 O00626 CCL22_HUMAN 76.389 0.755319 1.01075 CCL22 - C-C motif chemokine 22 precursor - Homo sapiens (Human) - CCL22 gene May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. Taurus_UMD|evm.model.AC_000175.1.283 P80075 CCL8_HUMAN 51.786 0.124424 4.38384 CCL8 - C-C motif chemokine 8 precursor - Homo sapiens (Human) - CCL8 gene Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. Taurus_UMD|evm.model.AC_000175.1.284 Q8I021 CCL17_FELCA 61.333 0.718447 1.0404 CCL17 - C-C motif chemokine 17 precursor - Felis catus (Cat) - CCL17 gene Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). Taurus_UMD|evm.model.AC_000175.1.285 Q5EAC7 CPIN1_BOVIN 99.678 0.99359 1.00645 CIAPIN1 - Anamorsin - Bos taurus (Bovine) - CIAPIN1 gene Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells. Taurus_UMD|evm.model.AC_000175.1.286 Q2NL34 COQ9_BOVIN 100.000 0.99375 1.00313 COQ9 - Ubiquinone biosynthesis protein COQ9, mitochondrial precursor - Bos taurus (Bovine) - COQ9 gene Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7. Taurus_UMD|evm.model.AC_000175.1.287 Q3T0Q3 RPB3_BOVIN 100.000 0.992754 1.00364 POLR2C - DNA-directed RNA polymerase II subunit RPB3 - Bos taurus (Bovine) - POLR2C gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity). Taurus_UMD|evm.model.AC_000175.1.288 Q8TEW6 DOK4_HUMAN 98.466 0.993884 1.00307 DOK4 - Docking protein 4 - Homo sapiens (Human) - DOK4 gene DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. Taurus_UMD|evm.model.AC_000175.1.289 A0JNH6 C102A_BOVIN 100.000 0.996403 1.0018 CCDC102A - Coiled-coil domain-containing protein 102A - Bos taurus (Bovine) - CCDC102A gene Taurus_UMD|evm.model.AC_000175.1.290 Q8IZF4 AGRG5_HUMAN 74.809 0.98855 0.992424 ADGRG5 - Adhesion G-protein coupled receptor G5 precursor - Homo sapiens (Human) - ADGRG5 gene Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking). Taurus_UMD|evm.model.AC_000175.1.291 Q50DM6 AGRG1_GORGO 81.951 0.836401 0.71179 ADGRG1 - Adhesion G-protein coupled receptor G1 precursor - Gorilla gorilla gorilla (Western lowland gorilla) - ADGRG1 gene Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity).Plays an essential role in testis development. Plays a critical role in tumourigenesis. Taurus_UMD|evm.model.AC_000175.1.292 Q8K209 AGRG1_MOUSE 90.367 0.809701 0.390102 Adgrg1 - Adhesion G-protein coupled receptor G1 precursor - Mus musculus (Mouse) - Adgrg1 gene Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (PubMed:21768377). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (By similarity). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (PubMed:23478665). Plays a critical role in tumourigenesis (By similarity). Plays essential role in testis development (PubMed:20981830). Taurus_UMD|evm.model.AC_000175.1.293 Q86Y34 AGRG3_HUMAN 66.126 0.99635 0.998179 ADGRG3 - Adhesion G protein-coupled receptor G3 precursor - Homo sapiens (Human) - ADGRG3 gene Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658). Taurus_UMD|evm.model.AC_000175.1.294 Q2T9M4 DRC7_BOVIN 100.000 0.997709 1.00115 DRC7 - Dynein regulatory complex subunit 7 - Bos taurus (Bovine) - DRC7 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility. Taurus_UMD|evm.model.AC_000175.1.295 Q9BVA0 KTNB1_HUMAN 95.626 0.996988 1.01374 KATNB1 - Katanin p80 WD40 repeat-containing subunit B1 - Homo sapiens (Human) - KATNB1 gene Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. Taurus_UMD|evm.model.AC_000175.1.296 Q9BVG8 KIFC3_HUMAN 96.814 0.75261 1.15006 KIFC3 - Kinesin-like protein KIFC3 - Homo sapiens (Human) - KIFC3 gene Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance. Taurus_UMD|evm.model.AC_000175.1.297 Q28181 CNGB1_BOVIN 98.853 0.998558 0.994978 CNGB1 - Cyclic nucleotide-gated cation channel beta-1 - Bos taurus (Bovine) - CNGB1 gene Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP (By similarity). Taurus_UMD|evm.model.AC_000175.1.298 Q2YDM5 TEPP_BOVIN 99.359 0.714286 1.39103 TEPP - Testis, prostate and placenta-expressed protein - Bos taurus (Bovine) - TEPP gene Taurus_UMD|evm.model.AC_000175.1.299 Q9P2F9 ZN319_HUMAN 96.758 0.996593 1.00859 ZNF319 - Zinc finger protein 319 - Homo sapiens (Human) - ZNF319 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.300 Q0II50 USB1_BOVIN 100.000 0.992481 1.00377 USB1 - U6 snRNA phosphodiesterase - Bos taurus (Bovine) - USB1 gene Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Taurus_UMD|evm.model.AC_000175.1.301 P51511 MMP15_HUMAN 93.037 0.997041 1.01046 MMP15 - Matrix metalloproteinase-15 precursor - Homo sapiens (Human) - MMP15 gene Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. Taurus_UMD|evm.model.AC_000175.1.302 Q8BTU1 CFA20_MOUSE 100.000 0.989691 1.00518 Cfap20 - Cilia- and flagella-associated protein 20 - Mus musculus (Mouse) - Cfap20 gene Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). Taurus_UMD|evm.model.AC_000175.1.303 P20427 CSK22_BOVIN 99.684 0.990566 0.908571 CSNK2A2 - Casein kinase II subunit alpha' - Bos taurus (Bovine) - CSNK2A2 gene Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins (By similarity). Taurus_UMD|evm.model.AC_000175.1.304 Q3SZX9 CC113_BOVIN 100.000 0.994898 1.00256 CCDC113 - Coiled-coil domain-containing protein 113 - Bos taurus (Bovine) - CCDC113 gene Component of centriolar satellites contributing to primary cilium formation. Taurus_UMD|evm.model.AC_000175.1.305 Q6PEW0 PRS54_HUMAN 58.869 0.846325 1.13671 PRSS54 - Inactive serine protease 54 precursor - Homo sapiens (Human) - PRSS54 gene extracellular space, serine-type endopeptidase activity, proteolysis Taurus_UMD|evm.model.AC_000175.1.306 Q08E12 PSF3_BOVIN 100.000 0.990783 1.00463 GINS3 - DNA replication complex GINS protein PSF3 - Bos taurus (Bovine) - GINS3 gene The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. Taurus_UMD|evm.model.AC_000175.1.307 Q9ULP0 NDRG4_HUMAN 94.493 0.844388 1.11364 NDRG4 - Protein NDRG4 - Homo sapiens (Human) - NDRG4 gene Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. Taurus_UMD|evm.model.AC_000175.1.308 E1BI64 SETD6_BOVIN 100.000 0.995565 1.00222 SETD6 - N-lysine methyltransferase SETD6 - Bos taurus (Bovine) - SETD6 gene Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity). Taurus_UMD|evm.model.AC_000175.1.309 A5YKK6 CNOT1_HUMAN 99.747 0.999159 1.00042 CNOT1 - CCR4-NOT transcription complex subunit 1 - Homo sapiens (Human) - CNOT1 gene Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Taurus_UMD|evm.model.AC_000175.1.310 A7E3U5 S38A7_BOVIN 100.000 0.99569 1.00216 SLC38A7 - Putative sodium-coupled neutral amino acid transporter 7 - Bos taurus (Bovine) - SLC38A7 gene Mediates sodium-dependent transport of amino acids, preferentially L-glutamine. Taurus_UMD|evm.model.AC_000175.1.311 P12344 AATM_BOVIN 100.000 0.99536 1.00233 GOT2 - Aspartate aminotransferase, mitochondrial precursor - Bos taurus (Bovine) - GOT2 gene Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. Taurus_UMD|evm.model.AC_000175.1.312 P62936 PPIA_PIG 78.022 0.818182 0.670732 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Taurus_UMD|evm.model.AC_000175.1.315 P55286 CADH8_HUMAN 99.595 0.921348 0.334168 CDH8 - Cadherin-8 precursor - Homo sapiens (Human) - CDH8 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Taurus_UMD|evm.model.AC_000175.1.316 P55286 CADH8_HUMAN 72.170 0.686667 0.375469 CDH8 - Cadherin-8 precursor - Homo sapiens (Human) - CDH8 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Taurus_UMD|evm.model.AC_000175.1.317 P55286 CADH8_HUMAN 99.415 0.829684 0.514393 CDH8 - Cadherin-8 precursor - Homo sapiens (Human) - CDH8 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Taurus_UMD|evm.model.AC_000175.1.319 P55286 CADH8_HUMAN 95.238 0.988095 0.105131 CDH8 - Cadherin-8 precursor - Homo sapiens (Human) - CDH8 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Taurus_UMD|evm.model.AC_000175.1.320 Q3SZ90 RL13A_BOVIN 75.214 0.982906 0.576355 RPL13A - 60S ribosomal protein L13a - Bos taurus (Bovine) - RPL13A gene Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity). Taurus_UMD|evm.model.AC_000175.1.321 P55287 CAD11_HUMAN 98.744 0.997491 1.00126 CDH11 - Cadherin-11 precursor - Homo sapiens (Human) - CDH11 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Taurus_UMD|evm.model.AC_000175.1.323 Q6URK6 CADH5_BOVIN 98.810 0.839196 0.254151 CDH5 - Cadherin-5 precursor - Bos taurus (Bovine) - CDH5 gene Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (By similarity). Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (By similarity). Taurus_UMD|evm.model.AC_000175.1.324 Q6URK6 CADH5_BOVIN 99.838 0.918155 0.858238 CDH5 - Cadherin-5 precursor - Bos taurus (Bovine) - CDH5 gene Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (By similarity). Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (By similarity). Taurus_UMD|evm.model.AC_000175.1.325 Q3B7T3 BEAN1_HUMAN 83.784 0.992188 0.988417 BEAN1 - Protein BEAN1 - Homo sapiens (Human) - BEAN1 gene Taurus_UMD|evm.model.AC_000175.1.326 Q66HP6 SPAT2_RAT 40.000 0.185804 0.937378 Spata2 - Spermatogenesis-associated protein 2 - Rattus norvegicus (Rat) - Spata2 gene Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (By similarity). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity). Taurus_UMD|evm.model.AC_000175.1.327 Q9N0C5 KITM_MACFA 82.772 0.952899 1.04151 TK2 - Thymidine kinase 2, mitochondrial precursor - Macaca fascicularis (Crab-eating macaque) - TK2 gene Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents. Taurus_UMD|evm.model.AC_000175.1.328 Q9UBR5 CKLF_HUMAN 73.649 0.98 0.986842 CKLF - Chemokine-like factor - Homo sapiens (Human) - CKLF gene May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10. Taurus_UMD|evm.model.AC_000175.1.329 Q8IZ96 CKLF1_HUMAN 59.006 0.565217 1.63314 CMTM1 - CKLF-like MARVEL transmembrane domain-containing protein 1 - Homo sapiens (Human) - CMTM1 gene integral component of membrane Taurus_UMD|evm.model.AC_000175.1.330 Q96MX0 CKLF3_HUMAN 90.511 0.467354 1.5989 CMTM3 - CKLF-like MARVEL transmembrane domain-containing protein 3 - Homo sapiens (Human) - CMTM3 gene cytoplasmic vesicle, cytosol, integral component of membrane Taurus_UMD|evm.model.AC_000175.1.331 Q8CJ61 CKLF4_MOUSE 97.115 0.990431 1.00481 Cmtm4 - CKLF-like MARVEL transmembrane domain-containing protein 4 - Mus musculus (Mouse) - Cmtm4 gene Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation. Taurus_UMD|evm.model.AC_000175.1.332 O43237 DC1L2_HUMAN 98.374 0.995943 1.00203 DYNC1LI2 - Cytoplasmic dynein 1 light intermediate chain 2 - Homo sapiens (Human) - DYNC1LI2 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Taurus_UMD|evm.model.AC_000175.1.333 Q13564 ULA1_HUMAN 97.590 0.428818 2.17041 NAE1 - NEDD8-activating enzyme E1 regulatory subunit - Homo sapiens (Human) - NAE1 gene Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. Taurus_UMD|evm.model.AC_000175.1.334 P43166 CAH7_HUMAN 95.076 0.992453 1.00379 CA7 - Carbonic anhydrase 7 - Homo sapiens (Human) - CA7 gene Reversible hydration of carbon dioxide. Taurus_UMD|evm.model.AC_000175.1.335 Q9P2J9 PDP2_HUMAN 87.170 0.994361 1.00567 PDP2 - [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor - Homo sapiens (Human) - PDP2 gene Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. Taurus_UMD|evm.model.AC_000175.1.336 O75309 CAD16_HUMAN 80.579 0.99759 1.00121 CDH16 - Cadherin-16 precursor - Homo sapiens (Human) - CDH16 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Taurus_UMD|evm.model.AC_000175.1.337 P55042 RAD_HUMAN 95.455 0.993528 1.00325 RRAD - GTP-binding protein RAD - Homo sapiens (Human) - RRAD gene May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. Taurus_UMD|evm.model.AC_000175.1.338 Q9Y3D0 CIA2B_HUMAN 87.363 0.989071 1.1227 CIAO2B - Cytosolic iron-sulfur assembly component 2B - Homo sapiens (Human) - CIAO2B gene Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004, PubMed:22678362, PubMed:22678361, PubMed:29848660). As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins (PubMed:23891004, PubMed:29848660). As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis (PubMed:29848660). Taurus_UMD|evm.model.AC_000175.1.339 O00748 EST2_HUMAN 71.971 0.98556 0.991055 CES2 - Cocaine esterase precursor - Homo sapiens (Human) - CES2 gene Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984). Taurus_UMD|evm.model.AC_000175.1.340 Q5RCL7 EST3_PONAB 71.429 0.977233 1.00351 CES3 - Carboxylesterase 3 precursor - Pongo abelii (Sumatran orangutan) - CES3 gene Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Taurus_UMD|evm.model.AC_000175.1.341 P0C6R3 EST4A_BOVIN 98.887 0.981752 0.996364 CES4A - Carboxylesterase 4A precursor - Bos taurus (Bovine) - CES4A gene Probable carboxylesterase. Taurus_UMD|evm.model.AC_000175.1.342 Q13951 PEBB_HUMAN 99.451 0.989071 1.00549 CBFB - Core-binding factor subunit beta - Homo sapiens (Human) - CBFB gene Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. Taurus_UMD|evm.model.AC_000175.1.343 Q9BSU1 CP070_HUMAN 97.393 0.995272 1.00237 PHAF1 - Phagosome assembly factor 1 - Homo sapiens (Human) - PHAF1 gene Plays a regulatory role in autophagic activity. In complex with BCAS3, associates with the autophagosome formation site during both non-selective and selective autophagy. Taurus_UMD|evm.model.AC_000175.1.344 Q17QZ8 B3GN9_BOVIN 93.220 0.916667 0.897756 B3GNT9 - UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 - Bos taurus (Bovine) - B3GNT9 gene Golgi apparatus, acetylgalactosaminyltransferase activity, acetylglucosaminyltransferase activity, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity, poly-N-acetyllactosamine biosynthetic process, protein glycosylation Taurus_UMD|evm.model.AC_000175.1.345 Q2KI74 TRADD_BOVIN 100.000 0.99361 1.00321 TRADD - Tumor necrosis factor receptor type 1-associated DEATH domain protein - Bos taurus (Bovine) - TRADD gene Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Taurus_UMD|evm.model.AC_000175.1.346 Q08DG4 FBXL8_BOVIN 99.733 0.686924 1.45187 FBXL8 - F-box/LRR-repeat protein 8 - Bos taurus (Bovine) - FBXL8 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000175.1.347 Q1HGE8 HSF4_CANLF 93.089 0.995927 0.997967 HSF4 - Heat shock factor protein 4 - Canis lupus familiaris (Dog) - HSF4 gene DNA-binding protein that specifically binds heat shock promoter elements (HSE). Taurus_UMD|evm.model.AC_000175.1.348 O60936 NOL3_HUMAN 87.919 0.714976 0.995192 NOL3 - Nucleolar protein 3 - Homo sapiens (Human) - NOL3 gene May be involved in RNA splicing. Taurus_UMD|evm.model.AC_000175.1.349 Q0VCR8 EX3L1_BOVIN 99.852 0.517638 1.76455 EXOC3L1 - Exocyst complex component 3-like protein - Bos taurus (Bovine) - EXOC3L1 gene As part of the exocyst, may play a role in regulated exocytosis of insulin granules. Taurus_UMD|evm.model.AC_000175.1.350 Q16254 E2F4_HUMAN 86.605 0.995283 1.02663 E2F4 - Transcription factor E2F4 - Homo sapiens (Human) - E2F4 gene Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Taurus_UMD|evm.model.AC_000175.1.351 A6QR40 ELMO3_BOVIN 99.846 0.901526 1.10583 ELMO3 - Engulfment and cell motility protein 3 - Bos taurus (Bovine) - ELMO3 gene Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). Taurus_UMD|evm.model.AC_000175.1.352 Q8WV35 LRC29_HUMAN 82.659 0.276527 2.78924 LRRC29 - Leucine-rich repeat-containing protein 29 - Homo sapiens (Human) - LRRC29 gene Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Taurus_UMD|evm.model.AC_000175.1.353 Q3SZZ5 TM208_BOVIN 100.000 0.988506 1.00578 TMEM208 - Transmembrane protein 208 - Bos taurus (Bovine) - TMEM208 gene May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. Taurus_UMD|evm.model.AC_000175.1.354 Q6P9Q4 FHOD1_MOUSE 90.072 0.487654 0.947368 Fhod1 - FH1/FH2 domain-containing protein 1 - Mus musculus (Mouse) - Fhod1 gene Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing (By similarity). Taurus_UMD|evm.model.AC_000175.1.355 Q9Z0X2 SL9A5_RAT 96.041 0.980022 1.00334 Slc9a5 - Sodium/hydrogen exchanger 5 - Rattus norvegicus (Rat) - Slc9a5 gene Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity). Taurus_UMD|evm.model.AC_000175.1.357 Q58EX7 PKHG4_HUMAN 80.451 0.998329 1.00504 PLEKHG4 - Puratrophin-1 - Homo sapiens (Human) - PLEKHG4 gene Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. Taurus_UMD|evm.model.AC_000175.1.358 A7YWH3 KCD19_BOVIN 100.000 0.997845 1.00108 KCTD19 - BTB/POZ domain-containing protein KCTD19 - Bos taurus (Bovine) - KCTD19 gene Taurus_UMD|evm.model.AC_000175.1.359 Q1X8D7 LRC36_HUMAN 85.960 0.994702 1.00133 LRRC36 - Leucine-rich repeat-containing protein 36 - Homo sapiens (Human) - LRRC36 gene Taurus_UMD|evm.model.AC_000175.1.360 Q3ZCC8 TPPP3_BOVIN 100.000 0.988701 1.00568 TPPP3 - Tubulin polymerization-promoting protein family member 3 - Bos taurus (Bovine) - TPPP3 gene Regulator of microtubule dynamic that has microtubule bundling activity (By similarity). Required for embryo implantation; possibly by regulating beta-catenin (By similarity). Also required for decidualization via regulation of beta-catenin (By similarity). Taurus_UMD|evm.model.AC_000175.1.361 Q8WTX9 ZDHC1_HUMAN 96.765 0.701863 0.995876 ZDHHC1 - Palmitoyltransferase ZDHHC1 - Homo sapiens (Human) - ZDHHC1 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (By similarity). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation. Taurus_UMD|evm.model.AC_000175.1.362 P50168 DHI2_SHEEP 99.160 0.879012 0.948478 HSD11B2 - Corticosteroid 11-beta-dehydrogenase isozyme 2 - Ovis aries (Sheep) - HSD11B2 gene Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Taurus_UMD|evm.model.AC_000175.1.363 Q5R6I1 VA0D1_PONAB 100.000 0.994318 1.00285 ATP6V0D1 - V-type proton ATPase subunit d 1 - Pongo abelii (Sumatran orangutan) - ATP6V0D1 gene Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). Taurus_UMD|evm.model.AC_000175.1.364 P56413 AGRP_BOVIN 99.254 0.985185 1.00746 AGRP - Agouti-related protein precursor - Bos taurus (Bovine) - AGRP gene Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. Taurus_UMD|evm.model.AC_000175.1.366 Q68FE6 RIPR1_MOUSE 95.522 0.638756 0.341783 Ripor1 - Rho family-interacting cell polarization regulator 1 - Mus musculus (Mouse) - Ripor1 gene Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation. Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation. Taurus_UMD|evm.model.AC_000175.1.367 P49711 CTCF_HUMAN 99.450 0.997253 1.00138 CTCF - Transcriptional repressor CTCF - Homo sapiens (Human) - CTCF gene Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome. Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays an important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping. Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point for nucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing the propagation of stable methylation at the escape genes from X- inactivation. Involved in sister chromatid cohesion. Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites. Regulates asynchronous replication of IGF2/H19. Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640). Taurus_UMD|evm.model.AC_000175.1.368 Q6F5E8 CARL2_HUMAN 87.500 0.998571 0.97561 CARMIL2 - Capping protein, Arp2/3 and myosin-I linker protein 2 - Homo sapiens (Human) - CARMIL2 gene Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26578515, PubMed:26466680). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26578515, PubMed:26466680). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647349, PubMed:27647348, PubMed:28112205). Taurus_UMD|evm.model.AC_000175.1.369 Q96AP0 ACD_HUMAN 71.834 0.866412 1.1441 ACD - Adrenocortical dysplasia protein homolog - Homo sapiens (Human) - ACD gene Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. Taurus_UMD|evm.model.AC_000175.1.370 Q9NPB6 PAR6A_HUMAN 97.980 0.957655 0.887283 PARD6A - Partitioning defective 6 homolog alpha - Homo sapiens (Human) - PARD6A gene Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). Taurus_UMD|evm.model.AC_000175.1.371 Q3T078 ENKD1_BOVIN 99.713 0.994269 1.00287 ENKD1 - Enkurin domain-containing protein 1 - Bos taurus (Bovine) - ENKD1 gene cytoplasmic microtubule Taurus_UMD|evm.model.AC_000175.1.372 Q6ZW13 CP086_HUMAN 70.717 0.99375 1.00946 C16orf86 - Uncharacterized protein C16orf86 - Homo sapiens (Human) - C16orf86 gene Taurus_UMD|evm.model.AC_000175.1.373 Q5BIP5 GFOD2_BOVIN 100.000 0.994819 1.0026 GFOD2 - Glucose-fructose oxidoreductase domain-containing protein 2 precursor - Bos taurus (Bovine) - GFOD2 gene Promotes matrix assembly. Taurus_UMD|evm.model.AC_000175.1.374 A3KMV8 RBP10_BOVIN 99.677 0.921131 1.08387 RANBP10 - Ran-binding protein 10 - Bos taurus (Bovine) - RANBP10 gene May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). Taurus_UMD|evm.model.AC_000175.1.375 Q2TAA8 TXIP1_HUMAN 84.347 0.878179 1.13526 TSNAXIP1 - Translin-associated factor X-interacting protein 1 - Homo sapiens (Human) - TSNAXIP1 gene Possible role in spermatogenesis. Taurus_UMD|evm.model.AC_000175.1.376 Q4R5U8 CENPT_MACFA 68.687 0.860927 0.807487 CENPT - Centromere protein T - Macaca fascicularis (Crab-eating macaque) - CENPT gene Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. Taurus_UMD|evm.model.AC_000175.1.377 A5PKF5 THA11_BOVIN 100.000 0.993421 1.0033 THAP11 - THAP domain-containing protein 11 - Bos taurus (Bovine) - THAP11 gene Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity). Taurus_UMD|evm.model.AC_000175.1.378 P61972 NTF2_RAT 100.000 0.984375 1.00787 Nutf2 - Nuclear transport factor 2 - Rattus norvegicus (Rat) - Nutf2 gene Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. Taurus_UMD|evm.model.AC_000175.1.379 Q6P2E9 EDC4_HUMAN 95.357 0.997145 1 EDC4 - Enhancer of mRNA-decapping protein 4 - Homo sapiens (Human) - EDC4 gene In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). Taurus_UMD|evm.model.AC_000175.1.380 Q496H8 NRN1L_HUMAN 83.838 0.576471 1.0303 NRN1L - Neuritin-like protein precursor - Homo sapiens (Human) - NRN1L gene extracellular region, plasma membrane Taurus_UMD|evm.model.AC_000175.1.381 Q0V7M1 KPSH1_BOVIN 100.000 0.995294 1.00236 PSKH1 - Serine/threonine-protein kinase H1 - Bos taurus (Bovine) - PSKH1 gene May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing. Taurus_UMD|evm.model.AC_000175.1.382 Q3T0T1 PSB10_BOVIN 100.000 0.984496 0.945055 PSMB10 - Proteasome subunit beta type-10 precursor - Bos taurus (Bovine) - PSMB10 gene The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides (By similarity). Taurus_UMD|evm.model.AC_000175.1.383 P04180 LCAT_HUMAN 91.224 0.979592 1.00227 LCAT - Phosphatidylcholine-sterol acyltransferase precursor - Homo sapiens (Human) - LCAT gene Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:10722751). Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:8016111). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (PubMed:8016111). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (PubMed:24620755). Taurus_UMD|evm.model.AC_000175.1.384 Q28677 S12A4_RABIT 96.703 0.99817 1.00737 SLC12A4 - Solute carrier family 12 member 4 - Oryctolagus cuniculus (Rabbit) - SLC12A4 gene Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia. Taurus_UMD|evm.model.AC_000175.1.385 Q5M872 DPEP2_RAT 76.980 0.478261 1.6736 Dpep2 - Dipeptidase 2 precursor - Rattus norvegicus (Rat) - Dpep2 gene Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4). Does not hydrolyze cystinyl-bis-glycine. Taurus_UMD|evm.model.AC_000175.1.386 Q9NUL7 DDX28_HUMAN 85.185 0.987179 1.01111 DDX28 - Probable ATP-dependent RNA helicase DDX28 - Homo sapiens (Human) - DDX28 gene Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (PubMed:11350955). Taurus_UMD|evm.model.AC_000175.1.387 Q9NX74 DUS2L_HUMAN 91.684 0.995951 1.00203 DUS2 - tRNA-dihydrouridine(20) synthase [NAD(P)+]-like - Homo sapiens (Human) - DUS2 gene Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:15994936, PubMed:26429968, PubMed:30149704). Negatively regulates the activation of EIF2AK2/PKR (PubMed:18096616). Taurus_UMD|evm.model.AC_000175.1.388 Q12968 NFAC3_HUMAN 93.581 0.998138 0.99907 NFATC3 - Nuclear factor of activated T-cells, cytoplasmic 3 - Homo sapiens (Human) - NFATC3 gene Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Along with NFATC4, involved in embryonic heart development (By similarity). Taurus_UMD|evm.model.AC_000175.1.389 Q8K0G8 ESRP2_MOUSE 94.143 0.973538 1.00139 Esrp2 - Epithelial splicing regulatory protein 2 - Mus musculus (Mouse) - Esrp2 gene mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). Taurus_UMD|evm.model.AC_000175.1.391 Q8WMP9 PAG15_BOVIN 100.000 0.995098 1.00246 PLA2G15 - Phospholipase A2 group XV precursor - Bos taurus (Bovine) - PLA2G15 gene Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:11790796, PubMed:9525960). Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity) (PubMed:11790796, PubMed:9525960). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines (By similarity). Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines (By similarity). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (By similarity). Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress. Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance (By similarity). At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (By similarity). Taurus_UMD|evm.model.AC_000175.1.392 Q92536 YLAT2_HUMAN 89.903 0.996124 1.00194 SLC7A6 - Y+L amino acid transporter 2 - Homo sapiens (Human) - SLC7A6 gene Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells. Taurus_UMD|evm.model.AC_000175.1.393 Q1JQE2 S7A6O_BOVIN 100.000 0.993506 1.00326 SLC7A6OS - Probable RNA polymerase II nuclear localization protein SLC7A6OS - Bos taurus (Bovine) - SLC7A6OS gene Directs RNA polymerase II nuclear import. Taurus_UMD|evm.model.AC_000175.1.394 A6QQV6 ANM7_BOVIN 99.712 0.988588 1.00863 PRMT7 - Protein arginine N-methyltransferase 7 - Bos taurus (Bovine) - PRMT7 gene Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. Taurus_UMD|evm.model.AC_000175.1.395 O35049 NSMA2_RAT 89.650 0.996956 1.00305 Smpd3 - Sphingomyelin phosphodiesterase 3 - Rattus norvegicus (Rat) - Smpd3 gene Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location (By similarity). Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions. Taurus_UMD|evm.model.AC_000175.1.396 Q8TF47 ZFP90_HUMAN 90.110 0.996855 1 ZFP90 - Zinc finger protein 90 homolog - Homo sapiens (Human) - ZFP90 gene Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes. Taurus_UMD|evm.model.AC_000175.1.397 P19535 CADH3_BOVIN 100.000 0.504634 1.9776 CDH3 - Cadherin-3 - Bos taurus (Bovine) - CDH3 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Taurus_UMD|evm.model.AC_000175.1.398 Q6R8F2 CADH1_BOVIN 97.520 0.997392 0.869615 CDH1 - Cadherin-1 precursor - Bos taurus (Bovine) - CDH1 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. Taurus_UMD|evm.model.AC_000175.1.399 Q9C0B7 TNG6_HUMAN 86.015 0.985375 1 TANGO6 - Transport and Golgi organization protein 6 homolog - Homo sapiens (Human) - TANGO6 gene protein secretion Taurus_UMD|evm.model.AC_000175.1.400 O00219 HYAS3_HUMAN 98.915 0.900489 1.1085 HAS3 - Hyaluronan synthase 3 - Homo sapiens (Human) - HAS3 gene Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity). Taurus_UMD|evm.model.AC_000175.1.401 P0CG10 DERPC_BOVIN 99.815 0.996303 1.00185 DERPC - Decreased expression in renal and prostate cancer protein - Bos taurus (Bovine) - DERPC gene Potential tumor suppressor. Taurus_UMD|evm.model.AC_000175.1.403 Q969X6 UTP4_HUMAN 91.691 0.997089 1.00146 UTP4 - U3 small nucleolar RNA-associated protein 4 homolog - Homo sapiens (Human) - UTP4 gene Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase (PubMed:17699751, PubMed:19732766). May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (PubMed:19732766). Taurus_UMD|evm.model.AC_000175.1.404 Q13425 SNTB2_HUMAN 98.333 0.947276 1.0537 SNTB2 - Beta-2-syntrophin - Homo sapiens (Human) - SNTB2 gene Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. Taurus_UMD|evm.model.AC_000175.1.405 Q793F9 VPS4A_RAT 98.856 0.995434 1.00229 Vps4a - Vacuolar protein sorting-associated protein 4A - Rattus norvegicus (Rat) - Vps4a gene Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Taurus_UMD|evm.model.AC_000175.1.406 Q9HBH1 DEFM_HUMAN 81.739 0.912351 1.03292 PDF - Peptide deformylase, mitochondrial precursor - Homo sapiens (Human) - PDF gene Removes the formyl group from the N-terminal Met of newly synthesized proteins. Taurus_UMD|evm.model.AC_000175.1.407 Q2TBH9 COG8_BOVIN 99.840 0.99681 1.0016 COG8 - Conserved oligomeric Golgi complex subunit 8 - Bos taurus (Bovine) - COG8 gene Required for normal Golgi function. Taurus_UMD|evm.model.AC_000175.1.408 Q56P27 NIP7_PIG 98.889 0.98895 1.00556 NIP7 - 60S ribosome subunit biogenesis protein NIP7 homolog - Sus scrofa (Pig) - NIP7 gene Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly. Taurus_UMD|evm.model.AC_000175.1.409 Q0VCA9 TMED6_BOVIN 100.000 0.788779 1.2625 TMED6 - Transmembrane emp24 domain-containing protein 6 precursor - Bos taurus (Bovine) - TMED6 gene COPII-coated ER to Golgi transport vesicle, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, Golgi apparatus, endoplasmic reticulum to Golgi vesicle-mediated transport, Golgi organization, intracellular protein transport Taurus_UMD|evm.model.AC_000175.1.410 Q15554 TERF2_HUMAN 91.321 0.972426 1.00369 TERF2 - Telomeric repeat-binding factor 2 - Homo sapiens (Human) - TERF2 gene Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length. Taurus_UMD|evm.model.AC_000175.1.411 O43169 CYB5B_HUMAN 80.000 0.70283 1.41333 CYB5B - Cytochrome b5 type B precursor - Homo sapiens (Human) - CYB5B gene Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. Taurus_UMD|evm.model.AC_000175.1.412 O94916 NFAT5_HUMAN 93.175 0.998706 1.0098 NFAT5 - Nuclear factor of activated T-cells 5 - Homo sapiens (Human) - NFAT5 gene Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Taurus_UMD|evm.model.AC_000175.1.413 P15559 NQO1_HUMAN 90.876 0.992727 1.00365 NQO1 - NAD(P)H dehydrogenase [quinone] 1 - Homo sapiens (Human) - NQO1 gene The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. Taurus_UMD|evm.model.AC_000175.1.414 Q3T042 NOB1_BOVIN 99.758 0.895652 1.1138 NOB1 - RNA-binding protein NOB1 - Bos taurus (Bovine) - NOB1 gene May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). Taurus_UMD|evm.model.AC_000175.1.415 O00308 WWP2_HUMAN 95.287 0.997704 1.00115 WWP2 - NEDD4-like E3 ubiquitin-protein ligase WWP2 - Homo sapiens (Human) - WWP2 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. Taurus_UMD|evm.model.AC_000175.1.416 Q3ZBD0 PSMD7_BOVIN 100.000 0.993808 1.00311 PSMD7 - 26S proteasome non-ATPase regulatory subunit 7 - Bos taurus (Bovine) - PSMD7 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Taurus_UMD|evm.model.AC_000175.1.417 P14381 YTX2_XENLA 24.832 0.944828 0.110856 Transposon TX1 uncharacterized 149 kDa protein - Xenopus laevis (African clawed frog) Taurus_UMD|evm.model.AC_000175.1.420 Q15911 ZFHX3_HUMAN 93.965 0.99946 1.00054 ZFHX3 - Zinc finger homeobox protein 3 - Homo sapiens (Human) - ZFHX3 gene Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). Taurus_UMD|evm.model.AC_000175.1.421 Q8TBY8 PMFBP_HUMAN 75.470 0.922936 1.08242 PMFBP1 - Polyamine-modulated factor 1-binding protein 1 - Homo sapiens (Human) - PMFBP1 gene Required for normal spermatogenesis (PubMed:1770140, PubMed:30032984, PubMed:30298696). It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity (PubMed:30032984). May also be involved in the general organization of cellular cytoskeleton (By similarity). Taurus_UMD|evm.model.AC_000175.1.422 Q17R09 PRP16_BOVIN 96.908 0.987685 0.992665 DHX38 - Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 - Bos taurus (Bovine) - DHX38 gene Probable ATP-binding RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Taurus_UMD|evm.model.AC_000175.1.423 Q9NX01 TXN4B_HUMAN 97.315 0.986667 1.00671 TXNL4B - Thioredoxin-like protein 4B - Homo sapiens (Human) - TXNL4B gene Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition. Taurus_UMD|evm.model.AC_000175.1.424 Q2TBU0 HPT_BOVIN 99.750 0.563559 1.76559 HP - Haptoglobin precursor - Bos taurus (Bovine) - HP gene As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity). Taurus_UMD|evm.model.AC_000175.1.425 Q5E9W3 PYRD_BOVIN 78.613 0.839024 0.518987 DHODH - Dihydroorotate dehydrogenase (quinone), mitochondrial precursor - Bos taurus (Bovine) - DHODH gene Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Taurus_UMD|evm.model.AC_000175.1.426 Q7Z443 PK1L3_HUMAN 72.378 0.163678 0.998268 PKD1L3 - Polycystic kidney disease protein 1-like 3 precursor - Homo sapiens (Human) - PKD1L3 gene Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. Taurus_UMD|evm.model.AC_000175.1.427 Q3ZBV1 IST1_BOVIN 99.451 0.994521 1.00275 IST1 - IST1 homolog - Bos taurus (Bovine) - IST1 gene ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST. Taurus_UMD|evm.model.AC_000175.1.429 Q32KS7 ZN821_BOVIN 100.000 0.995157 1.00243 ZNF821 - Zinc finger protein 821 - Bos taurus (Bovine) - ZNF821 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.430 P0C7T5 ATX1L_HUMAN 92.743 0.997093 0.998549 ATXN1L - Ataxin-1-like - Homo sapiens (Human) - ATXN1L gene Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). Taurus_UMD|evm.model.AC_000175.1.431 P62246 RS15A_RAT 98.462 0.984733 1.00769 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Taurus_UMD|evm.model.AC_000175.1.432 O43747 AP1G1_HUMAN 99.030 0.997579 1.00487 AP1G1 - AP-1 complex subunit gamma-1 - Homo sapiens (Human) - AP1G1 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). Taurus_UMD|evm.model.AC_000175.1.433 Q6ZVD8 PHLP2_HUMAN 93.273 0.972694 1.02419 PHLPP2 - PH domain leucine-rich repeat-containing protein phosphatase 2 - Homo sapiens (Human) - PHLPP2 gene Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). Taurus_UMD|evm.model.AC_000175.1.434 Q9D956 MALD3_MOUSE 43.243 0.942708 1.02128 Marveld3 - MARVEL domain-containing protein 3 - Mus musculus (Mouse) - Marveld3 gene As a component of tight junctions, plays a role in paracellular ion conductivity. Taurus_UMD|evm.model.AC_000175.1.435 Q58CZ9 ATTY_BOVIN 99.776 0.877953 1.13647 TAT - Tyrosine aminotransferase - Bos taurus (Bovine) - TAT gene Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity for phenylalanine (By similarity). Taurus_UMD|evm.model.AC_000175.1.436 Q8NCG5 CHST4_HUMAN 78.877 0.951531 1.01554 CHST4 - Carbohydrate sulfotransferase 4 - Homo sapiens (Human) - CHST4 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2-branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location. Taurus_UMD|evm.model.AC_000175.1.437 P17027 ZNF23_HUMAN 84.424 0.890278 1.11975 ZNF23 - Zinc finger protein 23 - Homo sapiens (Human) - ZNF23 gene May be involved in transcriptional regulation. May have a role in embryonic development. Taurus_UMD|evm.model.AC_000175.1.438 A0A1W2PR48 TLE7_HUMAN 66.140 0.995455 0.997732 TLE7 - Transducin-like enhancer protein 7 - Homo sapiens (Human) - TLE7 gene nucleus, transcription regulator complex, repressing transcription factor binding, transcription corepressor activity, negative regulation of canonical Wnt signaling pathway Taurus_UMD|evm.model.AC_000175.1.440 Q3ZBY3 CALB2_BOVIN 99.631 0.992647 1.00369 CALB2 - Calretinin - Bos taurus (Bovine) - CALB2 gene Calretinin is a calcium-binding protein which is abundant in auditory neurons. Taurus_UMD|evm.model.AC_000175.1.441 Q5RAY7 CMTR2_PONAB 87.008 0.992157 0.994798 CMTR2 - Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 - Pongo abelii (Sumatran orangutan) - CMTR2 gene S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs. Taurus_UMD|evm.model.AC_000175.1.442 Q4G0P3 HYDIN_HUMAN 75.787 0.984612 0.951767 HYDIN - Hydrocephalus-inducing protein homolog - Homo sapiens (Human) - HYDIN gene Required for ciliary motility. Taurus_UMD|evm.model.AC_000175.1.443 P59045 NAL11_HUMAN 46.809 0.547059 0.164569 NLRP11 - NACHT, LRR and PYD domains-containing protein 11 - Homo sapiens (Human) - NLRP11 gene Involved in inflammation. Taurus_UMD|evm.model.AC_000175.1.444 Q2KIB9 RPP29_BOVIN 100.000 0.99095 1.00455 POP4 - Ribonuclease P protein subunit p29 - Bos taurus (Bovine) - POP4 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Taurus_UMD|evm.model.AC_000175.1.445 Q96S99 PKHF1_HUMAN 91.756 0.929766 1.07168 PLEKHF1 - Pleckstrin homology domain-containing family F member 1 - Homo sapiens (Human) - PLEKHF1 gene May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. Taurus_UMD|evm.model.AC_000175.1.446 Q08DM5 CS012_BOVIN 99.291 0.985915 1.00709 Protein C19orf12 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000175.1.447 P39949 CCNE1_RAT 83.871 0.804348 1.11922 Ccne1 - G1/S-specific cyclin-E1 - Rattus norvegicus (Rat) - Ccne1 gene Essential for the control of the cell cycle at the G1/S (start) transition. Taurus_UMD|evm.model.AC_000175.1.448 Q3B7M7 RMP_BOVIN 99.809 0.99619 1.00191 URI1 - Unconventional prefoldin RPB5 interactor - Bos taurus (Bovine) - URI1 gene Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region (By similarity). Taurus_UMD|evm.model.AC_000175.1.450 O15090 ZN536_HUMAN 92.615 0.997694 1.00077 ZNF536 - Zinc finger protein 536 - Homo sapiens (Human) - ZNF536 gene May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'. Taurus_UMD|evm.model.AC_000175.1.455 Q63HK5 TSH3_HUMAN 95.463 0.998071 0.959297 TSHZ3 - Teashirt homolog 3 - Homo sapiens (Human) - TSHZ3 gene Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). Taurus_UMD|evm.model.AC_000175.1.458 P11309 PIM1_HUMAN 73.239 0.605863 0.980831 PIM1 - Serine/threonine-protein kinase pim-1 - Homo sapiens (Human) - PIM1 gene Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B, induces 14-3-3 proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis. Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells (PubMed:18056989). Promotes brown adipocyte differentiation (By similarity). Taurus_UMD|evm.model.AC_000175.1.459 Q8NBZ7 UXS1_HUMAN 76.648 0.897959 0.933333 UXS1 - UDP-glucuronic acid decarboxylase 1 - Homo sapiens (Human) - UXS1 gene Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis. Taurus_UMD|evm.model.AC_000175.1.461 Q8TCN5 ZN507_HUMAN 83.177 0.985885 0.966422 ZNF507 - Zinc finger protein 507 - Homo sapiens (Human) - ZNF507 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.462 Q6ZPD9 D19L3_HUMAN 92.318 0.997211 1.0014 DPY19L3 - Probable C-mannosyltransferase DPY19L3 - Homo sapiens (Human) - DPY19L3 gene Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Taurus_UMD|evm.model.AC_000175.1.463 Q2HJH9 PDCD5_BOVIN 100.000 0.984127 1.008 PDCD5 - Programmed cell death protein 5 - Bos taurus (Bovine) - PDCD5 gene May function in the process of apoptosis. Taurus_UMD|evm.model.AC_000175.1.464 Q96NW4 ANR27_HUMAN 88.762 0.998093 0.999048 ANKRD27 - Ankyrin repeat domain-containing protein 27 - Homo sapiens (Human) - ANKRD27 gene May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Taurus_UMD|evm.model.AC_000175.1.465 Q8MJG0 R9BP_BOVIN 100.000 0.991597 1.00422 RGS9BP - Regulator of G-protein signaling 9-binding protein - Bos taurus (Bovine) - RGS9BP gene Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity). Taurus_UMD|evm.model.AC_000175.1.466 A8MXV4 NUD19_HUMAN 70.681 0.994764 1.01867 NUDT19 - Nucleoside diphosphate-linked moiety X motif 19 - Homo sapiens (Human) - NUDT19 gene Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity). Taurus_UMD|evm.model.AC_000175.1.467 Q587J7 TDR12_HUMAN 80.875 0.870869 1.10535 TDRD12 - Putative ATP-dependent RNA helicase TDRD12 - Homo sapiens (Human) - TDRD12 gene Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. Taurus_UMD|evm.model.AC_000175.1.468 P82251 BAT1_HUMAN 88.501 0.995902 1.00205 SLC7A9 - b(0,+)-type amino acid transporter 1 - Homo sapiens (Human) - SLC7A9 gene Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule. Taurus_UMD|evm.model.AC_000175.1.470 Q96ST8 CEP89_HUMAN 75.195 0.996114 0.985951 CEP89 - Centrosomal protein of 89 kDa - Homo sapiens (Human) - CEP89 gene Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. Taurus_UMD|evm.model.AC_000175.1.471 Q2KHY5 FAP24_BOVIN 100.000 0.918455 1.08372 FAAP24 - Fanconi anemia core complex-associated protein 24 - Bos taurus (Bovine) - FAAP24 gene Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA (By similarity). Taurus_UMD|evm.model.AC_000175.1.472 A4FUC9 RHPN2_BOVIN 99.708 0.997089 1.00146 RHPN2 - Rhophilin-2 - Bos taurus (Bovine) - RHPN2 gene Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity). Taurus_UMD|evm.model.AC_000175.1.473 Q24K12 GPTC1_BOVIN 98.711 0.997831 0.990333 GPATCH1 - G patch domain-containing protein 1 - Bos taurus (Bovine) - GPATCH1 gene Taurus_UMD|evm.model.AC_000175.1.474 Q6ZMY6 WDR88_HUMAN 71.429 0.909836 1.0339 WDR88 - WD repeat-containing protein 88 - Homo sapiens (Human) - WDR88 gene Taurus_UMD|evm.model.AC_000175.1.475 O75074 LRP3_HUMAN 91.315 0.997446 1.01688 LRP3 - Low-density lipoprotein receptor-related protein 3 precursor - Homo sapiens (Human) - LRP3 gene Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro. Taurus_UMD|evm.model.AC_000175.1.476 P63116 AAA1_RAT 95.938 0.81746 1.18868 Slc7a10 - Asc-type amino acid transporter 1 - Rattus norvegicus (Rat) - Slc7a10 gene Sodium-independent, high affinity transport of small neutral D- and L-amino acids and amino acid-related compounds. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse (By similarity). Taurus_UMD|evm.model.AC_000175.1.477 O02754 CEBPA_BOVIN 99.433 0.99435 1.00283 CEBPA - CCAAT/enhancer-binding protein alpha - Bos taurus (Bovine) - CEBPA gene Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes. During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung. Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage. To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Downregulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex. In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites. Taurus_UMD|evm.model.AC_000175.1.478 Q3T0B9 CEBPG_BOVIN 100.000 0.986667 1.00671 CEBPG - CCAAT/enhancer-binding protein gamma - Bos taurus (Bovine) - CEBPG gene Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter. Taurus_UMD|evm.model.AC_000175.1.479 P12955 PEPD_HUMAN 91.684 0.995951 1.00203 PEPD - Xaa-Pro dipeptidase - Homo sapiens (Human) - PEPD gene Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen. Taurus_UMD|evm.model.AC_000175.1.480 Q9H2A9 CHST8_HUMAN 90.909 0.98209 0.790094 CHST8 - Carbohydrate sulfotransferase 8 - Homo sapiens (Human) - CHST8 gene Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin. Taurus_UMD|evm.model.AC_000175.1.482 Q0VD00 KCD15_BOVIN 100.000 0.992958 1.00353 KCTD15 - BTB/POZ domain-containing protein KCTD15 - Bos taurus (Bovine) - KCTD15 gene During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity). Taurus_UMD|evm.model.AC_000175.1.483 Q3MHF8 LS14A_BOVIN 99.781 0.978495 1.00432 LSM14A - Protein LSM14 homolog A - Bos taurus (Bovine) - LSM14A gene Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly. Taurus_UMD|evm.model.AC_000175.1.484 Q9GL27 TBXT_CANLF 87.879 0.307692 0.23908 TBXT - T-box transcription factor T - Canis lupus familiaris (Dog) - TBXT gene Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site. Taurus_UMD|evm.model.AC_000175.1.485 O15063 GRRE1_HUMAN 94.958 0.998134 1.00187 GARRE1 - Granule associated Rac and RHOG effector protein 1 - Homo sapiens (Human) - GARRE1 gene Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067). Taurus_UMD|evm.model.AC_000175.1.487 Q3ZBD7 G6PI_BOVIN 100.000 0.996416 1.0018 GPI - Glucose-6-phosphate isomerase - Bos taurus (Bovine) - GPI gene In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). Taurus_UMD|evm.model.AC_000175.1.488 Q9BRP1 PDD2L_HUMAN 80.055 0.99455 1.02514 PDCD2L - Programmed cell death protein 2-like - Homo sapiens (Human) - PDCD2L gene Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase. Taurus_UMD|evm.model.AC_000175.1.489 Q9UBT2 SAE2_HUMAN 97.969 0.99688 1.00156 UBA2 - SUMO-activating enzyme subunit 2 - Homo sapiens (Human) - UBA2 gene The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Taurus_UMD|evm.model.AC_000175.1.490 A6NIX2 WTIP_HUMAN 95.543 0.848341 0.981395 WTIP - Wilms tumor protein 1-interacting protein - Homo sapiens (Human) - WTIP gene Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Taurus_UMD|evm.model.AC_000175.1.491 Q0PGP2 ABP_MESAU 48.235 0.903226 0.808696 Androgen-binding protein homolog precursor - Mesocricetus auratus (Golden hamster) Taurus_UMD|evm.model.AC_000175.1.492 Q61187 TS101_MOUSE 85.897 0.870787 0.455243 Tsg101 - Tumor susceptibility gene 101 protein - Mus musculus (Mouse) - Tsg101 gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity). Taurus_UMD|evm.model.AC_000175.1.493 Q6UGQ3 SG2B2_MOUSE 51.852 0.672269 1.04386 Scgb2b2 - Secretoglobin family 2B member 2 precursor - Mus musculus (Mouse) - Scgb2b2 gene Taurus_UMD|evm.model.AC_000175.1.495 Q6UGQ3 SG2B2_MOUSE 43.137 0.87069 1.01754 Scgb2b2 - Secretoglobin family 2B member 2 precursor - Mus musculus (Mouse) - Scgb2b2 gene Taurus_UMD|evm.model.AC_000175.1.496 P30438 FEL1A_FELCA 51.471 0.690722 1.05435 CH1 - Major allergen I polypeptide chain 1 precursor - Felis catus (Cat) - CH1 gene extracellular region, steroid binding Taurus_UMD|evm.model.AC_000175.1.497 P30438 FEL1A_FELCA 52.941 0.531746 1.36957 CH1 - Major allergen I polypeptide chain 1 precursor - Felis catus (Cat) - CH1 gene extracellular region, steroid binding Taurus_UMD|evm.model.AC_000175.1.498 P30440 FEL1B_FELCA 37.736 0.889831 1.08257 CH2 - Major allergen I polypeptide chain 2 precursor - Felis catus (Cat) - CH2 gene Taurus_UMD|evm.model.AC_000175.1.499 P30438 FEL1A_FELCA 52.941 0.57265 1.27174 CH1 - Major allergen I polypeptide chain 1 precursor - Felis catus (Cat) - CH1 gene extracellular region, steroid binding Taurus_UMD|evm.model.AC_000175.1.500 P30438 FEL1A_FELCA 56.716 0.733333 0.978261 CH1 - Major allergen I polypeptide chain 1 precursor - Felis catus (Cat) - CH1 gene extracellular region, steroid binding Taurus_UMD|evm.model.AC_000175.1.501 Q2KI58 ZN181_BOVIN 99.825 0.910543 1.09825 ZNF181 - Zinc finger protein 181 - Bos taurus (Bovine) - ZNF181 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.502 Q96NL3 ZN599_HUMAN 84.536 0.62406 1.58333 ZNF599 - Zinc finger protein 599 - Homo sapiens (Human) - ZNF599 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.503 Q9ET32 BGAT1_RAT 60.185 0.946903 0.324713 Abo - Histo-blood group ABO system transferase 1 - Rattus norvegicus (Rat) - Abo gene Posseses strong A transferase activity and a weak B transferase activity. Taurus_UMD|evm.model.AC_000175.1.504 P38649 BGAT_MOUSE 60.090 0.970874 0.620482 Abo - Histo-blood group ABO system transferase - Mus musculus (Mouse) - Abo gene cytoplasmic vesicle, Golgi apparatus, vesicle, alpha-1,3-galactosyltransferase activity, antigen binding, fucosylgalactoside 3-alpha-galactosyltransferase activity, glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity, manganese ion binding, nucleotide binding, transferase activity, transferring glycosyl groups Taurus_UMD|evm.model.AC_000175.1.505 Q3KQV3 ZN792_HUMAN 62.342 0.987931 0.917722 ZNF792 - Zinc finger protein 792 - Homo sapiens (Human) - ZNF792 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.506 P0DP31 CALM3_RAT 94.690 0.982456 0.765101 Calm3 - Calmodulin-3 - Rattus norvegicus (Rat) - Calm3 gene Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Taurus_UMD|evm.model.AC_000175.1.507 Q96CP6 ASTRA_HUMAN 95.839 0.885043 1.1174 GRAMD1A - Protein Aster-A - Homo sapiens (Human) - GRAMD1A gene Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). Taurus_UMD|evm.model.AC_000175.1.508 Q17QN4 SCN1B_BOVIN 99.083 0.333333 2.98624 SCN1B - Sodium channel subunit beta-1 precursor - Bos taurus (Bovine) - SCN1B gene Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. Taurus_UMD|evm.model.AC_000175.1.510 P59645 FXYD3_RAT 89.855 0.8 0.965909 Fxyd3 - FXYD domain-containing ion transport regulator 3 precursor - Rattus norvegicus (Rat) - Fxyd3 gene Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. Taurus_UMD|evm.model.AC_000175.1.511 Q8N135 LGI4_HUMAN 92.664 0.959184 1.00372 LGI4 - Leucine-rich repeat LGI family member 4 precursor - Homo sapiens (Human) - LGI4 gene Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity). Taurus_UMD|evm.model.AC_000175.1.512 W5P3P0 PLM_SHEEP 100.000 0.442105 2.06522 FXYD1 - Phospholemman precursor - Ovis aries (Sheep) - FXYD1 gene Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. Taurus_UMD|evm.model.AC_000175.1.513 I3LMB3 PLM_PIG 52.632 0.212644 2 FXYD1 - Phospholemman precursor - Sus scrofa (Pig) - FXYD1 gene Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. Taurus_UMD|evm.model.AC_000175.1.514 Q17R55 F187B_HUMAN 56.640 0.994536 0.99187 FAM187B - Protein FAM187B precursor - Homo sapiens (Human) - FAM187B gene Taurus_UMD|evm.model.AC_000175.1.515 Q0VAY3 F187B_MOUSE 56.723 0.991632 0.667598 Fam187b - Protein FAM187B precursor - Mus musculus (Mouse) - Fam187b gene Taurus_UMD|evm.model.AC_000175.1.516 Q86X29 LSR_HUMAN 85.398 0.980263 0.702619 LSR - Lipolysis-stimulated lipoprotein receptor - Homo sapiens (Human) - LSR gene Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Taurus_UMD|evm.model.AC_000175.1.517 Q63665 USF2_RAT 97.846 0.920455 1.01734 Usf2 - Upstream stimulatory factor 2 - Rattus norvegicus (Rat) - Usf2 gene Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Taurus_UMD|evm.model.AC_000175.1.518 Q8MJ80 HEPC_PIG 79.592 0.827586 0.707317 HAMP - Hepcidin precursor - Sus scrofa (Pig) - HAMP gene Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity). Taurus_UMD|evm.model.AC_000175.1.519 P20916 MAG_HUMAN 94.409 0.99681 1.0016 MAG - Myelin-associated glycoprotein precursor - Homo sapiens (Human) - MAG gene Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity). Taurus_UMD|evm.model.AC_000175.1.520 Q9WU74 LSR_RAT 89.844 0.47037 0.455312 Lsr - Lipolysis-stimulated lipoprotein receptor precursor - Rattus norvegicus (Rat) - Lsr gene Probable role in the clearance of triglyceride-rich lipoprotein from plasma. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells. Taurus_UMD|evm.model.AC_000175.1.521 P20273 CD22_HUMAN 58.473 0.981043 0.996458 CD22 - B-cell receptor CD22 precursor - Homo sapiens (Human) - CD22 gene Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Taurus_UMD|evm.model.AC_000175.1.522 O14842 FFAR1_HUMAN 84.962 0.417981 2.11333 FFAR1 - Free fatty acid receptor 1 - Homo sapiens (Human) - FFAR1 gene G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. Taurus_UMD|evm.model.AC_000175.1.523 Q8VCK6 FFAR2_MOUSE 55.326 0.886986 0.884848 Ffar2 - Free fatty acid receptor 2 - Mus musculus (Mouse) - Ffar2 gene G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine (PubMed:22190648, PubMed:23589301). May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake (PubMed:20399779). Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes (PubMed:16123168, PubMed:23589301). In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines (PubMed:23665276). May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils (PubMed:19917676, PubMed:19865172). In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes. Taurus_UMD|evm.model.AC_000175.1.524 O15552 FFAR2_HUMAN 76.596 0.993939 1 FFAR2 - Free fatty acid receptor 2 - Homo sapiens (Human) - FFAR2 gene G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097). Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate (PubMed:12496283, PubMed:12711604). Exhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016). Taurus_UMD|evm.model.AC_000175.1.525 Q52MQ7 KTDAP_CANLF 92.929 0.98 1.0101 KRTDAP - Keratinocyte differentiation-associated protein precursor - Canis lupus familiaris (Dog) - KRTDAP gene May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis (By similarity). Taurus_UMD|evm.model.AC_000175.1.526 A6QQF6 SBSN_BOVIN 100.000 0.996416 1.0018 SBSN - Suprabasin precursor - Bos taurus (Bovine) - SBSN gene Taurus_UMD|evm.model.AC_000175.1.527 Q2KJE5 G3PT_BOVIN 98.015 0.467442 2.17722 GAPDHS - Glyceraldehyde-3-phosphate dehydrogenase, testis-specific - Bos taurus (Bovine) - GAPDHS gene May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity). Taurus_UMD|evm.model.AC_000175.1.528 I6VSD2 TM147_CAPHI 100.000 0.991111 1.00446 TMEM147 - Transmembrane protein 147 - Capra hircus (Goat) - TMEM147 gene Component of a ribosome-associated endoplasmic reticulum (ER) translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Together with SEC61 and TMCO1, forms the lipid-filled cavity at the center of the translocon where TMEM147 may insert hydrophobic segments of mutli-pass membrane proteins from the lumen into de central membrane cavity in a process gated by SEC61, and TMCO1 may insert hydrophobic segments of nascent chains from the cytosol into the cavity. Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Taurus_UMD|evm.model.AC_000175.1.529 P19156 ATP4A_PIG 99.122 0.992722 0.66441 ATP4A - Potassium-transporting ATPase alpha chain 1 - Sus scrofa (Pig) - ATP4A gene The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (PubMed:29618813, PubMed:31436534, PubMed:30143663, PubMed:19387495). Taurus_UMD|evm.model.AC_000175.1.530 P19156 ATP4A_PIG 99.582 0.955823 0.240812 ATP4A - Potassium-transporting ATPase alpha chain 1 - Sus scrofa (Pig) - ATP4A gene The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (PubMed:29618813, PubMed:31436534, PubMed:30143663, PubMed:19387495). Taurus_UMD|evm.model.AC_000175.1.531 Q45FY6 HPRT_PIG 90.323 0.308081 0.908257 HPRT1 - Hypoxanthine-guanine phosphoribosyltransferase - Sus scrofa (Pig) - HPRT1 gene Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). Taurus_UMD|evm.model.AC_000175.1.533 A7YY46 PNKD_BOVIN 80.198 0.699301 0.371429 PNKD - Probable hydrolase PNKD - Bos taurus (Bovine) - PNKD gene Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. Taurus_UMD|evm.model.AC_000175.1.534 O94927 HAUS5_HUMAN 80.380 0.995268 1.00158 HAUS5 - HAUS augmin-like complex subunit 5 - Homo sapiens (Human) - HAUS5 gene Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Taurus_UMD|evm.model.AC_000175.1.535 Q9BTD8 RBM42_HUMAN 98.125 0.995816 0.995833 RBM42 - RNA-binding protein 42 - Homo sapiens (Human) - RBM42 gene Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA. Taurus_UMD|evm.model.AC_000175.1.536 P38572 UPK1A_BOVIN 99.225 0.378498 2.63178 UPK1A - Uroplakin-1a - Bos taurus (Bovine) - UPK1A gene Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. Taurus_UMD|evm.model.AC_000175.1.537 Q9Y2Y4 ZBT32_HUMAN 76.119 0.953061 1.00616 ZBTB32 - Zinc finger and BTB domain-containing protein 32 - Homo sapiens (Human) - ZBTB32 gene DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity). Taurus_UMD|evm.model.AC_000175.1.538 Q9UMN6 KMT2B_HUMAN 91.143 0.999263 0.998895 KMT2B - Histone-lysine N-methyltransferase 2B - Homo sapiens (Human) - KMT2B gene Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:17707229). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:17707229). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). Taurus_UMD|evm.model.AC_000175.1.539 A5PJC7 IGFR1_BOVIN 99.721 0.899244 1.11204 IGFLR1 - IGF-like family receptor 1 precursor - Bos taurus (Bovine) - IGFLR1 gene Probable cell membrane receptor for the IGF-like family protein IGFL. Taurus_UMD|evm.model.AC_000175.1.540 Q3T127 U2AF4_BOVIN 100.000 0.908714 1.09545 U2AF1L4 - Splicing factor U2AF 26 kDa subunit - Bos taurus (Bovine) - U2AF1L4 gene RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). Taurus_UMD|evm.model.AC_000175.1.541 Q5G235 PEN2_BOVIN 100.000 0.980392 1.0099 PSENEN - Gamma-secretase subunit PEN-2 - Bos taurus (Bovine) - PSENEN gene Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity. Taurus_UMD|evm.model.AC_000175.1.542 Q1RMQ5 LIN37_BOVIN 100.000 0.991903 1.00407 LIN37 - Protein lin-37 homolog - Bos taurus (Bovine) - LIN37 gene Myb complex, negative regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000175.1.543 Q148F8 HSPB6_BOVIN 99.390 0.819095 1.21341 HSPB6 - Heat shock protein beta-6 - Bos taurus (Bovine) - HSPB6 gene Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. Taurus_UMD|evm.model.AC_000175.1.544 Q2NL68 PRSR3_HUMAN 75.352 0.435055 1.33125 PROSER3 - Proline and serine-rich protein 3 - Homo sapiens (Human) - PROSER3 gene Taurus_UMD|evm.model.AC_000175.1.545 O14559 RHG33_HUMAN 90.944 0.998415 0.980575 ARHGAP33 - Rho GTPase-activating protein 33 - Homo sapiens (Human) - ARHGAP33 gene May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity). Taurus_UMD|evm.model.AC_000175.1.546 Q3U0D9 HACE1_MOUSE 37.069 0.181388 0.69747 Hace1 - E3 ubiquitin-protein ligase HACE1 - Mus musculus (Mouse) - Hace1 gene E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens (By similarity). May also act as a transcription regulator via its interaction with RARB. Taurus_UMD|evm.model.AC_000175.1.547 A6QQ74 HYPDH_BOVIN 98.048 0.268849 3.7115 PRODH2 - Hydroxyproline dehydrogenase - Bos taurus (Bovine) - PRODH2 gene Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis. Taurus_UMD|evm.model.AC_000175.1.548 Q6UWL6 KIRR2_HUMAN 88.119 0.864699 1.14831 KIRREL2 - Kin of IRRE-like protein 2 precursor - Homo sapiens (Human) - KIRREL2 gene May regulate basal insulin secretion. Taurus_UMD|evm.model.AC_000175.1.549 P51693 APLP1_HUMAN 89.862 0.99689 0.989231 APLP1 - Amyloid-like protein 1 precursor - Homo sapiens (Human) - APLP1 gene May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. Taurus_UMD|evm.model.AC_000175.1.550 Q95J79 TYOBP_BOVIN 92.683 0.153992 4.87037 TYROBP - TYRO protein tyrosine kinase-binding protein precursor - Bos taurus (Bovine) - TYROBP gene Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (By similarity). Also mediates cell activation through association with activating receptors of the CD200R family (By similarity). Required for neutrophil activation mediated by integrin (By similarity). Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (By similarity). Associates with natural killer (NK) cell receptors such as the KLRD1/KLRC2 heterodimer to mediate NK cell activation (By similarity). Associates with TREM1 to mediate activation of neutrophils and monocytes (By similarity). Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity). Association with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) produced by TREM2 ectodomain shedding which suppresses the release of pro-inflammatory cytokines (By similarity). In microglia, required with TREM2 for phagocytosis of apoptotic neurons (By similarity). Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Promotes proinflammatory responses in microglia following nerve injury which accelerates degeneration of injured neurons (By similarity). Positively regulates the expression of the IRAK3/IRAK-M kinase and IL10 production by liver dendritic cells and inhibits their T cell allosimulatory ability (By similarity). Negatively regulates B cell proliferation (By similarity). Required for CSF1-mediated osteoclast cytoskeletal organization (By similarity). Positively regulates multinucleation during osteoclast development (By similarity). Taurus_UMD|evm.model.AC_000175.1.551 Q1RMS4 LRFN3_BOVIN 100.000 0.99682 1.00159 LRFN3 - Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor - Bos taurus (Bovine) - LRFN3 gene Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity). Taurus_UMD|evm.model.AC_000175.1.552 A8PU71 SDHF1_BOVIN 100.000 0.983193 1.00847 SDHAF1 - Succinate dehydrogenase assembly factor 1, mitochondrial - Bos taurus (Bovine) - SDHAF1 gene Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Taurus_UMD|evm.model.AC_000175.1.553 Q3KRA9 ALKB6_HUMAN 93.697 0.388525 2.56303 ALKBH6 - Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 - Homo sapiens (Human) - ALKBH6 gene Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron. Taurus_UMD|evm.model.AC_000175.1.554 Q96DZ5 CLIP3_HUMAN 98.172 0.65625 1.52102 CLIP3 - CAP-Gly domain-containing linker protein 3 - Homo sapiens (Human) - CLIP3 gene Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes. Taurus_UMD|evm.model.AC_000175.1.555 D3YYM0 OVOL3_MOUSE 85.106 0.105234 9.40212 Ovol3 - Putative transcription factor ovo-like protein 3 - Mus musculus (Mouse) - Ovol3 gene May act as a transcription regulator. Taurus_UMD|evm.model.AC_000175.1.556 P60899 RPB9_PIG 100.000 0.984127 1.008 POLR2I - DNA-directed RNA polymerase II subunit RPB9 - Sus scrofa (Pig) - POLR2I gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity). Taurus_UMD|evm.model.AC_000175.1.557 Q5E951 TBCB_BOVIN 100.000 0.991837 1.0041 TBCB - Tubulin-folding cofactor B - Bos taurus (Bovine) - TBCB gene Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. Taurus_UMD|evm.model.AC_000175.1.558 P13135 CPNS1_BOVIN 100.000 0.992424 1.0038 CAPNS1 - Calpain small subunit 1 - Bos taurus (Bovine) - CAPNS1 gene Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Taurus_UMD|evm.model.AC_000175.1.559 P07470 CX7A1_BOVIN 100.000 0.975309 1.0125 COX7A1 - Cytochrome c oxidase subunit 7A1, mitochondrial precursor - Bos taurus (Bovine) - COX7A1 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000175.1.560 Q8N9K5 ZN565_HUMAN 88.337 0.847039 1.12801 ZNF565 - Zinc finger protein 565 - Homo sapiens (Human) - ZNF565 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.561 Q28151 OZF_BOVIN 99.658 0.993174 1.00342 ZNF146 - Zinc finger protein OZF - Bos taurus (Bovine) - ZNF146 gene Taurus_UMD|evm.model.AC_000175.1.562 A2VDP4 ZN567_BOVIN 99.845 0.996914 1.00155 ZNF567 - Zinc finger protein 567 - Bos taurus (Bovine) - ZNF567 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.563 Q8TAF7 ZN461_HUMAN 77.143 0.588326 1.15631 ZNF461 - Zinc finger protein 461 - Homo sapiens (Human) - ZNF461 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.564 Q96SR6 ZN382_HUMAN 88.385 0.994575 1.00545 ZNF382 - Zinc finger protein 382 - Homo sapiens (Human) - ZNF382 gene Functions as a sequence-specific transcriptional repressor. Taurus_UMD|evm.model.AC_000175.1.565 Q6P280 ZN529_HUMAN 79.497 0.996124 0.916519 ZNF529 - Zinc finger protein 529 - Homo sapiens (Human) - ZNF529 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.566 Q6J6I6 ZN566_PANTR 80.556 0.617241 0.69378 ZNF566 - Zinc finger protein 566 - Pan troglodytes (Chimpanzee) - ZNF566 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.567 Q8N141 ZFP82_HUMAN 91.165 0.996219 0.994361 ZFP82 - Zinc finger protein 82 homolog - Homo sapiens (Human) - ZFP82 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.568 Q9HCL3 ZFP14_HUMAN 94.371 0.996248 1 ZFP14 - Zinc finger protein 14 homolog - Homo sapiens (Human) - ZFP14 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.569 Q3ZCX4 ZN568_HUMAN 83.019 0.564286 0.434783 ZNF568 - Zinc finger protein 568 - Homo sapiens (Human) - ZNF568 gene Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells. Taurus_UMD|evm.model.AC_000175.1.571 Q6P3V2 Z585A_HUMAN 91.964 0.763367 1.14304 ZNF585A - Zinc finger protein 585A - Homo sapiens (Human) - ZNF585A gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.572 Q8NA42 ZN383_HUMAN 93.474 0.995789 1 ZNF383 - Zinc finger protein 383 - Homo sapiens (Human) - ZNF383 gene May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways. Taurus_UMD|evm.model.AC_000175.1.573 Q3ZCX4 ZN568_HUMAN 49.196 0.713626 0.67236 ZNF568 - Zinc finger protein 568 - Homo sapiens (Human) - ZNF568 gene Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells. Taurus_UMD|evm.model.AC_000175.1.574 P10072 ZN875_HUMAN 63.081 0.976898 0.459788 ZNF875 - Zinc finger protein 875 - Homo sapiens (Human) - ZNF875 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.575 Q8NB42 ZN527_HUMAN 87.028 0.996721 1.00164 ZNF527 - Zinc finger protein 527 - Homo sapiens (Human) - ZNF527 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.576 Q5MCW4 ZN569_HUMAN 91.691 0.997085 1 ZNF569 - Zinc finger protein 569 - Homo sapiens (Human) - ZNF569 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.577 Q96NI8 ZN570_HUMAN 90.689 0.996276 1.00187 ZNF570 - Zinc finger protein 570 - Homo sapiens (Human) - ZNF570 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.578 A2VDQ7 ZN420_BOVIN 99.854 0.997093 1.00146 ZNF420 - Zinc finger protein 420 - Bos taurus (Bovine) - ZNF420 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.583 Q9Y2G7 ZFP30_HUMAN 89.869 0.994393 1.03083 ZFP30 - Zinc finger protein 30 homolog - Homo sapiens (Human) - ZFP30 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.584 Q86YE8 ZN573_HUMAN 75.000 0.0942029 0.622556 ZNF573 - Zinc finger protein 573 - Homo sapiens (Human) - ZNF573 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.585 Q6ZQQ6 WDR87_HUMAN 51.131 0.0720784 0.994779 WDR87 - WD repeat-containing protein 87 - Homo sapiens (Human) - WDR87 gene Taurus_UMD|evm.model.AC_000175.1.586 Q6ZQQ6 WDR87_HUMAN 64.207 0.178096 1.0456 WDR87 - WD repeat-containing protein 87 - Homo sapiens (Human) - WDR87 gene Taurus_UMD|evm.model.AC_000175.1.587 O60292 SI1L3_HUMAN 91.032 0.998861 0.985963 SIPA1L3 - Signal-induced proliferation-associated 1-like protein 3 - Homo sapiens (Human) - SIPA1L3 gene Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). Taurus_UMD|evm.model.AC_000175.1.588 P56163 DPF1_RAT 89.831 0.913525 1.13602 Dpf1 - Zinc finger protein neuro-d4 - Rattus norvegicus (Rat) - Dpf1 gene May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Taurus_UMD|evm.model.AC_000175.1.589 O18734 PP14A_PIG 97.959 0.986486 1.0068 CPI17 - Protein phosphatase 1 regulatory subunit 14A - Sus scrofa (Pig) - CPI17 gene Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Taurus_UMD|evm.model.AC_000175.1.590 O43291 SPIT2_HUMAN 74.206 0.992032 0.996032 SPINT2 - Kunitz-type protease inhibitor 2 precursor - Homo sapiens (Human) - SPINT2 gene Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa. Taurus_UMD|evm.model.AC_000175.1.592 Q5BJH7 YIF1B_HUMAN 93.046 0.96129 0.987261 YIF1B - Protein YIF1B - Homo sapiens (Human) - YIF1B gene Involved in the anterograde traffic pathway from the endoplasmic reticulum to the plasma membrane and the organization of the Golgi architecture (By similarity). Plays a key role in targeting to neuronal dendrites receptors such as HTR1A (By similarity). Taurus_UMD|evm.model.AC_000175.1.593 Q9Y257 KCNK6_HUMAN 88.179 0.99361 1 KCNK6 - Potassium channel subfamily K member 6 - Homo sapiens (Human) - KCNK6 gene Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions. Taurus_UMD|evm.model.AC_000175.1.595 Q4R6B2 CTSRG_MACFA 71.986 0.936455 0.257981 CATSPERG - Cation channel sperm-associated protein subunit gamma precursor - Macaca fascicularis (Crab-eating macaque) - CATSPERG gene Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Taurus_UMD|evm.model.AC_000175.1.596 Q6ZRH7 CTSRG_HUMAN 73.810 0.919558 0.547023 CATSPERG - Cation channel sperm-associated protein subunit gamma precursor - Homo sapiens (Human) - CATSPERG gene Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Taurus_UMD|evm.model.AC_000175.1.597 Q3SYT7 PSMD8_BOVIN 99.303 0.993056 1.00348 PSMD8 - 26S proteasome non-ATPase regulatory subunit 8 - Bos taurus (Bovine) - PSMD8 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Taurus_UMD|evm.model.AC_000175.1.598 Q80WJ1 GGN_MOUSE 82.979 0.0747967 0.913819 Ggn - Gametogenetin - Mus musculus (Mouse) - Ggn gene May be involved in spermatogenesis. Taurus_UMD|evm.model.AC_000175.1.599 Q2MJR0 SPRE3_HUMAN 96.697 0.481858 1.68049 SPRED3 - Sprouty-related, EVH1 domain-containing protein 3 - Homo sapiens (Human) - SPRED3 gene Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). Taurus_UMD|evm.model.AC_000175.1.600 Q1LZ97 GRP4_BOVIN 98.963 0.997041 1.00446 RASGRP4 - RAS guanyl-releasing protein 4 - Bos taurus (Bovine) - RASGRP4 gene Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation (By similarity). Taurus_UMD|evm.model.AC_000175.1.601 P16960 RYR1_PIG 98.094 0.999603 1.0002 RYR1 - Ryanodine receptor 1 - Sus scrofa (Pig) - RYR1 gene Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (By similarity). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). Taurus_UMD|evm.model.AC_000175.1.602 Q92918 M4K1_HUMAN 92.509 0.973203 0.985594 MAP4K1 - Mitogen-activated protein kinase kinase kinase kinase 1 - Homo sapiens (Human) - MAP4K1 gene Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026). Able to autophosphorylate (PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). Taurus_UMD|evm.model.AC_000175.1.603 Q3T0V3 EIF3K_BOVIN 100.000 0.990868 1.00459 EIF3K - Eukaryotic translation initiation factor 3 subunit K - Bos taurus (Bovine) - EIF3K gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Taurus_UMD|evm.model.AC_000175.1.604 A5D7D1 ACTN4_BOVIN 100.000 0.997807 1.0011 ACTN4 - Alpha-actinin-4 - Bos taurus (Bovine) - ACTN4 gene F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA. Taurus_UMD|evm.model.AC_000175.1.605 Q6ZSI9 CAN12_HUMAN 83.518 0.99723 1.00417 CAPN12 - Calpain-12 - Homo sapiens (Human) - CAPN12 gene Calcium-regulated non-lysosomal thiol-protease. Taurus_UMD|evm.model.AC_000175.1.606 O54974 LEG7_MOUSE 76.336 0.928571 1.02941 Lgals7 - Galectin-7 - Mus musculus (Mouse) - Lgals7 gene Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity). Taurus_UMD|evm.model.AC_000175.1.607 Q2KJD3 CWC15_BOVIN 93.182 0.75 0.502165 CWC15 - Spliceosome-associated protein CWC15 homolog - Bos taurus (Bovine) - CWC15 gene Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Taurus_UMD|evm.model.AC_000175.1.608 O54974 LEG7_MOUSE 75.573 0.928571 1.02941 Lgals7 - Galectin-7 - Mus musculus (Mouse) - Lgals7 gene Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity). Taurus_UMD|evm.model.AC_000175.1.609 Q3T0D6 LEG4_BOVIN 99.398 0.993994 1.00301 LGALS4 - Galectin-4 - Bos taurus (Bovine) - LGALS4 gene Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions (By similarity). Taurus_UMD|evm.model.AC_000175.1.610 Q5RFG0 ECH1_PONAB 80.464 0.920489 0.996951 ECH1 - Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - ECH1 gene Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA. Taurus_UMD|evm.model.AC_000175.1.611 P14866 HNRPL_HUMAN 98.642 0.996564 0.988115 HNRNPL - Heterogeneous nuclear ribonucleoprotein L - Homo sapiens (Human) - HNRNPL gene Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). Taurus_UMD|evm.model.AC_000175.1.612 Q5RJQ4 SIR2_RAT 92.739 0.316562 2.72571 Sirt2 - NAD-dependent protein deacetylase sirtuin-2 - Rattus norvegicus (Rat) - Sirt2 gene NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:17344398). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis. Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes. Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis. Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression. Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response. Deacetylates also histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition. During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter and thereby contributes to regulate expression of VEGFA, a key regulator of angiogenesis. Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells. Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination. Involved in several cellular metabolic pathways. Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability. Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage. Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis. Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity. Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells. Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy (By similarity). Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation (By similarity). Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia. Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimulation. Inhibits transcriptional activation by deacetylating p53/TP53 and EP300. Deacetylates also EIF5A. Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions. Plays a role as tumor suppressor (By similarity). Taurus_UMD|evm.model.AC_000175.1.613 Q15653 IKBB_HUMAN 86.555 0.99162 1.00562 NFKBIB - NF-kappa-B inhibitor beta - Homo sapiens (Human) - NFKBIB gene Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. Taurus_UMD|evm.model.AC_000175.1.614 I3L3R5 CCER2_HUMAN 68.487 0.865169 1.00376 CCER2 - Coiled-coil domain-containing glutamate-rich protein 2 precursor - Homo sapiens (Human) - CCER2 gene Taurus_UMD|evm.model.AC_000175.1.615 Q9N0F3 SYSM_BOVIN 100.000 0.996146 1.00193 SARS2 - Serine--tRNA ligase, mitochondrial precursor - Bos taurus (Bovine) - SARS2 gene Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). Taurus_UMD|evm.model.AC_000175.1.616 Q29RU1 RT12_BOVIN 100.000 0.985714 1.00719 MRPS12 - 28S ribosomal protein S12, mitochondrial precursor - Bos taurus (Bovine) - MRPS12 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, ribosome, structural constituent of ribosome, mitochondrial translation, translation Taurus_UMD|evm.model.AC_000175.1.617 Q96EF6 FBX17_HUMAN 91.039 0.817647 1.22302 FBXO17 - F-box only protein 17 - Homo sapiens (Human) - FBXO17 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins. Taurus_UMD|evm.model.AC_000175.1.618 Q8NI29 FBX27_HUMAN 50.775 0.898917 0.978799 FBXO27 - F-box only protein 27 - Homo sapiens (Human) - FBXO27 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Taurus_UMD|evm.model.AC_000175.1.619 Q9N0C8 FBX27_MACFA 53.571 0.108535 3.38929 FBXO27 - F-box only protein 27 - Macaca fascicularis (Crab-eating macaque) - FBXO27 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind complex-type oligosaccharides. Taurus_UMD|evm.model.AC_000175.1.620 Q8NI29 FBX27_HUMAN 49.466 0.916968 0.978799 FBXO27 - F-box only protein 27 - Homo sapiens (Human) - FBXO27 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Taurus_UMD|evm.model.AC_000175.1.621 Q5R8M9 RS19_PONAB 87.970 0.977444 0.917241 RPS19 - 40S ribosomal protein S19 - Pongo abelii (Sumatran orangutan) - RPS19 gene Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Taurus_UMD|evm.model.AC_000175.1.622 Q6ZNF0 ACP7_HUMAN 89.327 0.979499 1.00228 ACP7 - Acid phosphatase type 7 precursor - Homo sapiens (Human) - ACP7 gene Taurus_UMD|evm.model.AC_000175.1.623 O96013 PAK4_HUMAN 92.568 0.944354 1.03384 PAK4 - Serine/threonine-protein kinase PAK 4 - Homo sapiens (Human) - PAK4 gene Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Taurus_UMD|evm.model.AC_000175.1.624 Q6ZVX7 FBX50_HUMAN 80.727 0.992337 0.949091 NCCRP1 - F-box only protein 50 - Homo sapiens (Human) - NCCRP1 gene Promotes cell proliferation. Taurus_UMD|evm.model.AC_000175.1.625 Q0VAF6 SYCN_HUMAN 77.444 0.862745 1.14179 SYCN - Syncollin precursor - Homo sapiens (Human) - SYCN gene Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity). Taurus_UMD|evm.model.AC_000175.1.626 Q8IZI9 IFNL3_HUMAN 68.783 0.852535 1.10714 IFNL3 - Interferon lambda-3 precursor - Homo sapiens (Human) - IFNL3 gene Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. Taurus_UMD|evm.model.AC_000175.1.627 K9M1U5 IFNL4_HUMAN 68.715 0.956989 1.03911 IFNL4 - Interferon lambda-4 precursor - Homo sapiens (Human) - IFNL4 gene Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes. Taurus_UMD|evm.model.AC_000175.1.628 K9M1U5 IFNL4_HUMAN 68.317 0.970874 0.575419 IFNL4 - Interferon lambda-4 precursor - Homo sapiens (Human) - IFNL4 gene Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes. Taurus_UMD|evm.model.AC_000175.1.629 Q8IZI9 IFNL3_HUMAN 68.235 0.954023 0.443878 IFNL3 - Interferon lambda-3 precursor - Homo sapiens (Human) - IFNL3 gene Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. Taurus_UMD|evm.model.AC_000175.1.630 Q2WF71 LRFN1_MOUSE 92.371 0.965699 0.494778 Lrfn1 - Leucine-rich repeat and fibronectin type III domain-containing protein 1 precursor - Mus musculus (Mouse) - Lrfn1 gene Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1. Taurus_UMD|evm.model.AC_000175.1.631 Q9P244 LRFN1_HUMAN 98.619 0.965241 0.485084 LRFN1 - Leucine-rich repeat and fibronectin type III domain-containing protein 1 precursor - Homo sapiens (Human) - LRFN1 gene Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). Taurus_UMD|evm.model.AC_000175.1.632 Q56JZ9 GMFG_BOVIN 100.000 0.679612 1.4507 GMFG - Glia maturation factor gamma - Bos taurus (Bovine) - GMFG gene Arp2/3 complex binding, actin filament debranching, negative regulation of Arp2/3 complex-mediated actin nucleation Taurus_UMD|evm.model.AC_000175.1.634 Q6S9E0 TTP_SHEEP 98.738 0.328824 2.95692 ZFP36 - mRNA decay activator protein ZFP36 - Ovis aries (Sheep) - ZFP36 gene Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs. Self regulates by destabilizing its own mRNA. Binds to 3'-UTR ARE of numerous mRNAs. Binds also to ARE of its own mRNA. Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages. Plays also a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response. Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia. Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA. Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA. Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs. Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs. May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro. Involved in the delivery of target ARE-mRNAs to processing bodies (PBs). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing. Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages. Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion. Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis. Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells. Taurus_UMD|evm.model.AC_000175.1.635 Q9H7P9 PKHG2_HUMAN 77.085 0.998595 1.0267 PLEKHG2 - Pleckstrin homology domain-containing family G member 2 - Homo sapiens (Human) - PLEKHG2 gene May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). Taurus_UMD|evm.model.AC_000175.1.636 P62250 RS16_RAT 100.000 0.986395 1.00685 Rps16 - 40S ribosomal protein S16 - Rattus norvegicus (Rat) - Rps16 gene cytosolic small ribosomal subunit, small ribosomal subunit, RNA binding, structural constituent of ribosome, cellular response to leukemia inhibitory factor, liver regeneration, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit biogenesis, rRNA processing, translation Taurus_UMD|evm.model.AC_000175.1.637 Q5R405 SPT5H_PONAB 95.383 0.998075 0.959372 SUPT5H - Transcription elongation factor SPT5 - Pongo abelii (Sumatran orangutan) - SUPT5H gene Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity). Taurus_UMD|evm.model.AC_000175.1.638 Q3SZB3 TIM50_BOVIN 99.718 0.994382 1.00282 TIMM50 - Mitochondrial import inner membrane translocase subunit TIM50 precursor - Bos taurus (Bovine) - TIMM50 gene Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Taurus_UMD|evm.model.AC_000175.1.639 Q9NYJ7 DLL3_HUMAN 88.245 0.970199 0.977346 DLL3 - Delta-like protein 3 precursor - Homo sapiens (Human) - DLL3 gene Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity). Taurus_UMD|evm.model.AC_000175.1.640 P59797 SELV_HUMAN 40.196 0.993421 0.878613 SELENOV - Selenoprotein V - Homo sapiens (Human) - SELENOV gene May be involved in a redox-related process. Taurus_UMD|evm.model.AC_000175.1.641 Q17QW4 EID2_BOVIN 100.000 0.990909 1.00457 EID2 - EP300-interacting inhibitor of differentiation 2 - Bos taurus (Bovine) - EID2 gene Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex (By similarity). Taurus_UMD|evm.model.AC_000175.1.642 A8MUM7 LEG16_HUMAN 48.062 0.836601 1.07746 LGALS16 - Galectin-16 - Homo sapiens (Human) - LGALS16 gene Binds lactose with high affinity. Strong inducer of T-cell apoptosis. Taurus_UMD|evm.model.AC_000175.1.643 Q9Y463 DYR1B_HUMAN 98.728 0.911466 1.09539 DYRK1B - Dual specificity tyrosine-phosphorylation-regulated kinase 1B - Homo sapiens (Human) - DYRK1B gene Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). Taurus_UMD|evm.model.AC_000175.1.644 P22087 FBRL_HUMAN 98.077 0.809375 0.996885 FBL - rRNA 2'-O-methyltransferase fibrillarin - Homo sapiens (Human) - FBL gene S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (PubMed:24352239, PubMed:30540930, PubMed:32017898). Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (PubMed:30540930). Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239, PubMed:30540930). Taurus_UMD|evm.model.AC_000175.1.645 Q5RET3 AAGAB_PONAB 82.888 0.798283 0.739683 AAGAB - Alpha- and gamma-adaptin-binding protein p34 - Pongo abelii (Sumatran orangutan) - AAGAB gene May be involved in endocytic recycling of growth factor receptors such as EGFR. Taurus_UMD|evm.model.AC_000175.1.646 Q4R7L3 PRS6B_MACFA 91.648 0.995495 1.0622 PSMC4 - 26S proteasome regulatory subunit 6B - Macaca fascicularis (Crab-eating macaque) - PSMC4 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Taurus_UMD|evm.model.AC_000175.1.647 Q9Y6R7 FCGBP_HUMAN 70.417 0.961056 0.574838 FCGBP - IgGFc-binding protein precursor - Homo sapiens (Human) - FCGBP gene May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa. Taurus_UMD|evm.model.AC_000175.1.648 Q02779 M3K10_HUMAN 97.912 0.522404 0.959119 MAP3K10 - Mitogen-activated protein kinase kinase kinase 10 - Homo sapiens (Human) - MAP3K10 gene Activates the JUN N-terminal pathway. Taurus_UMD|evm.model.AC_000175.1.649 Q8N6N2 TTC9B_HUMAN 92.050 0.991525 0.987448 TTC9B - Tetratricopeptide repeat protein 9B - Homo sapiens (Human) - TTC9B gene Taurus_UMD|evm.model.AC_000175.1.650 Q9H8S5 CCNP_HUMAN 81.496 0.81877 1.00651 CCNP - Cyclin-P - Homo sapiens (Human) - CCNP gene Seems to be involved in the regulation of proliferation and migration. Taurus_UMD|evm.model.AC_000175.1.651 P31751 AKT2_HUMAN 98.753 0.995851 1.00208 AKT2 - RAC-beta serine/threonine-protein kinase - Homo sapiens (Human) - AKT2 gene AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Taurus_UMD|evm.model.AC_000175.1.652 Q8N9M1 CS047_HUMAN 91.990 0.994832 0.917062 C19orf47 - Uncharacterized protein C19orf47 - Homo sapiens (Human) - C19orf47 gene nucleoplasm, nucleus Taurus_UMD|evm.model.AC_000175.1.653 Q2KJJ8 PLD3_BOVIN 100.000 0.995927 1.00204 PLD3 - 5'-3' exonuclease PLD3 - Bos taurus (Bovine) - PLD3 gene 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity). Taurus_UMD|evm.model.AC_000175.1.654 Q8WP28 HIPK4_MACFA 88.979 0.996759 1.00162 HIPK4 - Homeodomain-interacting protein kinase 4 - Macaca fascicularis (Crab-eating macaque) - HIPK4 gene Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). Taurus_UMD|evm.model.AC_000175.1.655 E1BM58 PRAX_BOVIN 100.000 0.893307 1.11861 PRX - Periaxin - Bos taurus (Bovine) - PRX gene Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology. Taurus_UMD|evm.model.AC_000175.1.656 Q9UHV2 SRTD1_HUMAN 89.873 0.987448 1.01271 SERTAD1 - SERTA domain-containing protein 1 - Homo sapiens (Human) - SERTAD1 gene Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A. Taurus_UMD|evm.model.AC_000175.1.657 Q9UJW9 SRTD3_HUMAN 91.414 0.732342 1.37245 SERTAD3 - SERTA domain-containing protein 3 - Homo sapiens (Human) - SERTAD3 gene Strong transcriptional coactivator. Taurus_UMD|evm.model.AC_000175.1.658 P52556 BLVRB_BOVIN 100.000 0.990338 1.00485 BLVRB - Flavin reductase (NADPH) - Bos taurus (Bovine) - BLVRB gene Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. Taurus_UMD|evm.model.AC_000175.1.659 Q9H254 SPTN4_HUMAN 96.922 0.97974 1.02028 SPTBN4 - Spectrin beta chain, non-erythrocytic 4 - Homo sapiens (Human) - SPTBN4 gene actin filament, axon hillock, axon initial segment, cell body fiber, cytoplasm, cytosol, extracellular exosome, membrane, neuronal cell body, node of Ranvier Taurus_UMD|evm.model.AC_000175.1.660 A3KMV1 SHKB1_BOVIN 100.000 0.997163 1.00142 SHKBP1 - SH3KBP1-binding protein 1 - Bos taurus (Bovine) - SHKBP1 gene Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. Taurus_UMD|evm.model.AC_000175.1.661 Q8N2S1 LTBP4_HUMAN 72.881 0.717791 0.100369 LTBP4 - Latent-transforming growth factor beta-binding protein 4 precursor - Homo sapiens (Human) - LTBP4 gene Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Taurus_UMD|evm.model.AC_000175.1.662 Q8N2S1 LTBP4_HUMAN 87.903 0.951337 0.898399 LTBP4 - Latent-transforming growth factor beta-binding protein 4 precursor - Homo sapiens (Human) - LTBP4 gene Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Taurus_UMD|evm.model.AC_000175.1.663 Q9Y6R0 NUMBL_HUMAN 93.924 0.996644 0.978654 NUMBL - Numb-like protein - Homo sapiens (Human) - NUMBL gene Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. Taurus_UMD|evm.model.AC_000175.1.664 Q96D53 COQ8B_HUMAN 90.458 0.994297 0.966912 COQ8B - Atypical kinase COQ8B, mitochondrial - Homo sapiens (Human) - COQ8B gene Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:24270420). Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration (PubMed:24270420). Taurus_UMD|evm.model.AC_000175.1.665 Q96DU7 IP3KC_HUMAN 80.758 0.997041 0.989751 ITPKC - Inositol-trisphosphate 3-kinase C - Homo sapiens (Human) - ITPKC gene Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. Taurus_UMD|evm.model.AC_000175.1.666 A6QQD2 CS054_BOVIN 100.000 0.994269 1.00287 UPF0692 protein C19orf54 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000175.1.667 Q2KIR1 SNRPA_BOVIN 100.000 0.992933 1.00355 SNRPA - U1 small nuclear ribonucleoprotein A - Bos taurus (Bovine) - SNRPA gene Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity). Taurus_UMD|evm.model.AC_000175.1.668 Q28038 MIA_BOVIN 100.000 0.984733 1.00769 MIA - Melanoma-derived growth regulatory protein precursor - Bos taurus (Bovine) - MIA gene May function during cartilage development and maintenance. Taurus_UMD|evm.model.AC_000175.1.669 P61018 RAB4B_HUMAN 71.946 0.990991 1.04225 RAB4B - Ras-related protein Rab-4B - Homo sapiens (Human) - RAB4B gene Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (By similarity). Protein transport. Probably involved in vesicular traffic (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). Taurus_UMD|evm.model.AC_000175.1.670 Q96KS0 EGLN2_HUMAN 93.120 0.995 0.982801 EGLN2 - Prolyl hydroxylase EGLN2 - Homo sapiens (Human) - EGLN2 gene Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). Taurus_UMD|evm.model.AC_000175.1.671 P33267 CP2F2_MOUSE 50.920 0.519231 0.635438 Cyp2f2 - Cytochrome P450 2F2 - Mus musculus (Mouse) - Cyp2f2 gene Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or Clara cells in lung. Taurus_UMD|evm.model.AC_000175.1.672 Q96FX8 PERP_HUMAN 87.047 0.98913 0.953368 PERP - p53 apoptosis effector related to PMP-22 - Homo sapiens (Human) - PERP gene Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity). Taurus_UMD|evm.model.AC_000175.1.673 O18809 CP2F3_CAPHI 85.488 0.982301 0.690428 CYP2F3 - Cytochrome P450 2F3 - Capra hircus (Goat) - CYP2F3 gene Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. Stereoselectively catalyzes the formation of the 1R,2S-oxide from naphthalene. Lack activity with other common P450 substrates including 7-ethoxycoumarin. Taurus_UMD|evm.model.AC_000175.1.674 P11611 PP2AB_RABIT 99.308 0.982935 0.94822 PPP2CB - Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform - Oryctolagus cuniculus (Rabbit) - PPP2CB gene PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Taurus_UMD|evm.model.AC_000175.1.675 Q16696 CP2AD_HUMAN 91.972 0.953947 0.923077 CYP2A13 - Cytochrome P450 2A13 - Homo sapiens (Human) - CYP2A13 gene Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. Taurus_UMD|evm.model.AC_000175.1.676 P24461 CP2G1_RABIT 91.093 0.99596 1.00202 CYP2G1 - Cytochrome P450 2G1 - Oryctolagus cuniculus (Rabbit) - CYP2G1 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction. Taurus_UMD|evm.model.AC_000175.1.677 P00178 CP2B4_RABIT 69.307 0.242718 0.839104 CYP2B4 - Cytochrome P450 2B4 - Oryctolagus cuniculus (Rabbit) - CYP2B4 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin. Taurus_UMD|evm.model.AC_000175.1.678 P33272 CP2BC_RAT 69.767 0.125373 0.680894 Cyp2b12 - Cytochrome P450 2B12 - Rattus norvegicus (Rat) - Cyp2b12 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl. Taurus_UMD|evm.model.AC_000175.1.679 P00178 CP2B4_RABIT 82.166 0.949495 1.00815 CYP2B4 - Cytochrome P450 2B4 - Oryctolagus cuniculus (Rabbit) - CYP2B4 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it has a unique preference for the 5,6-olefin. Taurus_UMD|evm.model.AC_000175.1.680 Q8N6M6 AMPO_HUMAN 80.124 0.571429 0.34188 AOPEP - Aminopeptidase O - Homo sapiens (Human) - AOPEP gene Aminopeptidase which catalyzes the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Taurus_UMD|evm.model.AC_000175.1.681 P62856 RS26_RAT 92.857 0.570588 1.47826 Rps26 - 40S ribosomal protein S26 - Rattus norvegicus (Rat) - Rps26 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, mRNA binding, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000175.1.682 Q96SQ9 CP2S1_HUMAN 80.410 0.966887 0.89881 CYP2S1 - Cytochrome P450 2S1 - Homo sapiens (Human) - CYP2S1 gene A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids (PubMed:12711469, PubMed:21068195). In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12711469). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) (PubMed:21068195). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage (PubMed:21068195). Taurus_UMD|evm.model.AC_000175.1.683 P30530 UFO_HUMAN 95.405 0.55407 0.920582 AXL - Tyrosine-protein kinase receptor UFO precursor - Homo sapiens (Human) - AXL gene Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. Taurus_UMD|evm.model.AC_000175.1.684 Q9BUJ2 HNRL1_HUMAN 97.669 0.997672 1.0035 HNRNPUL1 - Heterogeneous nuclear ribonucleoprotein U-like protein 1 - Homo sapiens (Human) - HNRNPUL1 gene Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. Taurus_UMD|evm.model.AC_000175.1.685 Q96F63 CCD97_HUMAN 89.504 0.994152 0.997085 CCDC97 - Coiled-coil domain-containing protein 97 - Homo sapiens (Human) - CCDC97 gene Taurus_UMD|evm.model.AC_000175.1.686 P18341 TGFB1_BOVIN 99.410 0.936288 0.925641 TGFB1 - Transforming growth factor beta-1 proprotein precursor - Bos taurus (Bovine) - TGFB1 gene Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Taurus_UMD|evm.model.AC_000175.1.687 Q56JY9 B9D2_BOVIN 99.429 0.961326 1.03429 B9D2 - B9 domain-containing protein 2 - Bos taurus (Bovine) - B9D2 gene Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Taurus_UMD|evm.model.AC_000175.1.688 Q6ZNR0 TMM91_HUMAN 83.721 0.928571 1.05814 TMEM91 - Transmembrane protein 91 - Homo sapiens (Human) - TMEM91 gene Taurus_UMD|evm.model.AC_000175.1.689 Q9NQT4 EXOS5_HUMAN 88.843 0.99177 1.03404 EXOSC5 - Exosome complex component RRP46 - Homo sapiens (Human) - EXOSC5 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Taurus_UMD|evm.model.AC_000175.1.690 P11178 ODBA_BOVIN 100.000 0.957537 1.03516 BCKDHA - 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - BCKDHA gene The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Taurus_UMD|evm.model.AC_000175.1.691 A6QNS9 DMAC2_BOVIN 100.000 0.361319 2.21595 DMAC2 - Distal membrane-arm assembly complex protein 2 - Bos taurus (Bovine) - DMAC2 gene Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I. Taurus_UMD|evm.model.AC_000175.1.692 A6NGS2 ERIC4_HUMAN 69.466 0.984848 1.01538 ERICH4 - Glutamate-rich protein 4 - Homo sapiens (Human) - ERICH4 gene Taurus_UMD|evm.model.AC_000175.1.693 Q3SYY2 TPST2_BOVIN 47.895 0.980263 0.403183 TPST2 - Protein-tyrosine sulfotransferase 2 - Bos taurus (Bovine) - TPST2 gene Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. Taurus_UMD|evm.model.AC_000175.1.695 Q10126 YSM6_CAEEL 25.490 0.789474 0.408602 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000175.1.696 Q14002 CEAM7_HUMAN 53.719 0.529412 1.60377 CEACAM7 - Carcinoembryonic antigen-related cell adhesion molecule 7 precursor - Homo sapiens (Human) - CEACAM7 gene apical plasma membrane, extracellular region, plasma membrane Taurus_UMD|evm.model.AC_000175.1.698 P16386 LIPS_BOVIN 98.810 0.723873 1.37963 LIPE - Hormone-sensitive lipase - Bos taurus (Bovine) - LIPE gene Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (By similarity). Shows a preferential hydrolysis of DAGs over TAGs and MAGs (By similarity). Preferentially hydrolyzes fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs and FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity). Taurus_UMD|evm.model.AC_000175.1.699 Q0VBW2 CNFN_BOVIN 100.000 0.88 1.12613 CNFN - Cornifelin - Bos taurus (Bovine) - CNFN gene Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Taurus_UMD|evm.model.AC_000175.1.700 Q9QYP0 MEGF8_RAT 95.279 0.998863 0.630918 Megf8 - Multiple epidermal growth factor-like domains protein 8 precursor - Rattus norvegicus (Rat) - Megf8 gene Acts as a negative regulator of hedgehog signaling. Taurus_UMD|evm.model.AC_000175.1.701 P60882 MEGF8_MOUSE 94.629 0.984848 0.141986 Megf8 - Multiple epidermal growth factor-like domains protein 8 precursor - Mus musculus (Mouse) - Megf8 gene Acts as a negative regulator of hedgehog signaling (PubMed:29290584). Taurus_UMD|evm.model.AC_000175.1.702 Q7Z7M0 MEGF8_HUMAN 93.231 0.996928 0.228822 MEGF8 - Multiple epidermal growth factor-like domains protein 8 precursor - Homo sapiens (Human) - MEGF8 gene Acts as a negative regulator of hedgehog signaling. Taurus_UMD|evm.model.AC_000175.1.703 Q8NBT3 TM145_HUMAN 94.375 0.849291 1.14402 TMEM145 - Transmembrane protein 145 - Homo sapiens (Human) - TMEM145 gene Taurus_UMD|evm.model.AC_000175.1.704 Q0P5M0 PRR19_BOVIN 100.000 0.94026 1.06061 PRR19 - Proline-rich protein 19 - Bos taurus (Bovine) - PRR19 gene Taurus_UMD|evm.model.AC_000175.1.705 Q29460 PA1B3_BOVIN 100.000 0.991416 1.00431 PAFAH1B3 - Platelet-activating factor acetylhydrolase IB subunit alpha1 - Bos taurus (Bovine) - PAFAH1B3 gene Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF (PubMed:10542206). The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition (PubMed:10542206). Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) (PubMed:10542206). Plays an important role during the development of brain. Taurus_UMD|evm.model.AC_000175.1.707 Q96RK0 CIC_HUMAN 92.385 0.624013 1.57463 CIC - Protein capicua homolog - Homo sapiens (Human) - CIC gene Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. Taurus_UMD|evm.model.AC_000175.1.708 P50548 ERF_HUMAN 96.390 0.996383 1.00912 ERF - ETS domain-containing transcription factor ERF - Homo sapiens (Human) - ERF gene Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). Taurus_UMD|evm.model.AC_000175.1.709 P49840 GSK3A_HUMAN 96.273 0.995868 1.00207 GSK3A - Glycogen synthase kinase-3 alpha - Homo sapiens (Human) - GSK3A gene Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350). Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, leading to activate KAT5/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Taurus_UMD|evm.model.AC_000175.1.710 A6QR00 ZN526_BOVIN 100.000 0.99705 1.00148 ZNF526 - Zinc finger protein 526 - Bos taurus (Bovine) - ZNF526 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.711 Q8WXF8 DEDD2_HUMAN 93.884 0.993902 1.00613 DEDD2 - DNA-binding death effector domain-containing protein 2 - Homo sapiens (Human) - DEDD2 gene May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Taurus_UMD|evm.model.AC_000175.1.712 P09086 PO2F2_HUMAN 99.317 0.572549 1.06472 POU2F2 - POU domain, class 2, transcription factor 2 - Homo sapiens (Human) - POU2F2 gene Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874). Taurus_UMD|evm.model.AC_000175.1.713 Q29RK0 ZN574_BOVIN 100.000 0.997537 0.90625 ZNF574 - Zinc finger protein 574 - Bos taurus (Bovine) - ZNF574 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.714 Q16478 GRIK5_HUMAN 90.693 0.898271 1.00306 GRIK5 - Glutamate receptor ionotropic, kainate 5 precursor - Homo sapiens (Human) - GRIK5 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD. Taurus_UMD|evm.model.AC_000175.1.715 P13637 AT1A3_HUMAN 99.385 0.997951 0.963475 ATP1A3 - Sodium/potassium-transporting ATPase subunit alpha-3 - Homo sapiens (Human) - ATP1A3 gene This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Taurus_UMD|evm.model.AC_000175.1.716 Q1RMH4 PRAF1_BOVIN 100.000 0.736 1.35135 RABAC1 - Prenylated Rab acceptor protein 1 - Bos taurus (Bovine) - RABAC1 gene General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1. Taurus_UMD|evm.model.AC_000175.1.717 A0A1W2PQ73 ERFL_HUMAN 94.350 0.948925 1.05085 ERFL - ETS domain-containing transcription factor ERF-like - Homo sapiens (Human) - ERFL gene nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, cell differentiation, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000175.1.718 P40293 CD79A_BOVIN 100.000 0.180635 5.51121 CD79A - B-cell antigen receptor complex-associated protein alpha chain precursor - Bos taurus (Bovine) - CD79A gene Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells (By similarity). Taurus_UMD|evm.model.AC_000175.1.719 Q5R8M9 RS19_PONAB 100.000 0.986301 1.0069 RPS19 - 40S ribosomal protein S19 - Pongo abelii (Sumatran orangutan) - RPS19 gene Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Taurus_UMD|evm.model.AC_000175.1.720 Q32LE6 DMRTD_BOVIN 99.730 0.994609 1.0027 DMRTC2 - Doublesex- and mab-3-related transcription factor C2 - Bos taurus (Bovine) - DMRTC2 gene May be involved in sexual development. Taurus_UMD|evm.model.AC_000175.1.721 Q32LD3 LYPD4_BOVIN 100.000 0.991903 1.00407 LYPD4 - Ly6/PLAUR domain-containing protein 4 precursor - Bos taurus (Bovine) - LYPD4 gene anchored component of plasma membrane, plasma membrane raft Taurus_UMD|evm.model.AC_000175.1.722 P13688 CEAM1_HUMAN 48.867 0.729216 0.80038 CEACAM1 - Carcinoembryonic antigen-related cell adhesion molecule 1 precursor - Homo sapiens (Human) - CEACAM1 gene Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Downregulates neutrophil production by acting as a coinhibitory receptor for CSF3R by downregulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Downregulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interfers with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity). Taurus_UMD|evm.model.AC_000175.1.723 Q3KPI0 CEA21_HUMAN 40.873 0.961686 0.890785 CEACAM21 - Carcinoembryonic antigen-related cell adhesion molecule 21 precursor - Homo sapiens (Human) - CEACAM21 gene Taurus_UMD|evm.model.AC_000175.1.724 A4IFR0 CXL17_BOVIN 100.000 0.983193 1.00847 CXCL17 - C-X-C motif chemokine 17 precursor - Bos taurus (Bovine) - CXCL17 gene Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions. Taurus_UMD|evm.model.AC_000175.1.725 Q8N6Q3 CD177_HUMAN 53.531 0.970522 1.00915 CD177 - CD177 antigen precursor - Homo sapiens (Human) - CD177 gene In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369). Taurus_UMD|evm.model.AC_000175.1.726 Q9BY14 TX101_HUMAN 54.274 0.913386 1.02008 TEX101 - Testis-expressed protein 101 precursor - Homo sapiens (Human) - TEX101 gene Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity). Taurus_UMD|evm.model.AC_000175.1.727 P04557 SFP3_BOVIN 96.226 0.412698 0.9 Seminal plasma protein A3 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000175.1.728 P81019 SFP4_BOVIN 82.796 0.527778 0.786885 Seminal plasma protein BSP-30 kDa precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000175.1.729 O95274 LYPD3_HUMAN 75.652 0.947075 1.03757 LYPD3 - Ly6/PLAUR domain-containing protein 3 precursor - Homo sapiens (Human) - LYPD3 gene Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression. Taurus_UMD|evm.model.AC_000175.1.730 Q6NSJ2 PHLB3_HUMAN 80.093 0.892396 1.08906 PHLDB3 - Pleckstrin homology-like domain family B member 3 - Homo sapiens (Human) - PHLDB3 gene enzyme binding Taurus_UMD|evm.model.AC_000175.1.731 Q3T094 ETHE1_BOVIN 100.000 0.992157 1.00394 ETHE1 - Persulfide dioxygenase ETHE1, mitochondrial precursor - Bos taurus (Bovine) - ETHE1 gene Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus. Taurus_UMD|evm.model.AC_000175.1.732 Q9GM03 ZN575_MACFA 93.151 0.688889 1.21154 ZNF575 - Zinc finger protein 575 - Macaca fascicularis (Crab-eating macaque) - ZNF575 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.733 P18887 XRCC1_HUMAN 84.977 0.99696 1.03949 XRCC1 - DNA repair protein XRCC1 - Homo sapiens (Human) - XRCC1 gene Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity. Taurus_UMD|evm.model.AC_000175.1.734 Q9CQD7 PINLY_MOUSE 47.712 0.833333 0.849057 Pinlyp - phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein precursor - Mus musculus (Mouse) - Pinlyp gene Taurus_UMD|evm.model.AC_000175.1.735 P18887 XRCC1_HUMAN 85.417 0.389381 0.178515 XRCC1 - DNA repair protein XRCC1 - Homo sapiens (Human) - XRCC1 gene Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity. Taurus_UMD|evm.model.AC_000175.1.736 Q9CQD7 PINLY_MOUSE 47.716 0.965174 0.948113 Pinlyp - phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein precursor - Mus musculus (Mouse) - Pinlyp gene Taurus_UMD|evm.model.AC_000175.1.737 A6NC86 PINLY_HUMAN 47.312 0.593548 0.759804 PINLYP - phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein precursor - Homo sapiens (Human) - PINLYP gene Taurus_UMD|evm.model.AC_000175.1.738 Q8WZA9 IRGQ_HUMAN 83.227 0.990431 1.00642 IRGQ - Immunity-related GTPase family Q protein - Homo sapiens (Human) - IRGQ gene Taurus_UMD|evm.model.AC_000175.1.739 Q9H609 ZN576_HUMAN 82.941 0.988304 1.00588 ZNF576 - Zinc finger protein 576 - Homo sapiens (Human) - ZNF576 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.740 Q96B54 ZN428_HUMAN 91.753 0.989744 1.03723 ZNF428 - Zinc finger protein 428 - Homo sapiens (Human) - ZNF428 gene Taurus_UMD|evm.model.AC_000175.1.741 Q05588 UPAR_BOVIN 100.000 0.450599 2.02424 PLAUR - Urokinase plasminogen activator surface receptor precursor - Bos taurus (Bovine) - PLAUR gene Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. Taurus_UMD|evm.model.AC_000175.1.742 A6NC86 PINLY_HUMAN 27.152 0.383202 1.86765 PINLYP - phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein precursor - Homo sapiens (Human) - PINLYP gene Taurus_UMD|evm.model.AC_000175.1.743 Q64478 H2B1H_MOUSE 92.063 0.96875 1.01587 H2bc9 - Histone H2B type 1-H - Mus musculus (Mouse) - H2bc9 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000175.1.744 Q32KW9 IIGP5_BOVIN 99.785 0.995708 1.00215 IRGC - Interferon-inducible GTPase 5 - Bos taurus (Bovine) - IRGC gene Taurus_UMD|evm.model.AC_000175.1.745 Q6AYF9 IIGP5_RAT 45.013 0.866071 0.967603 Irgc - Interferon-inducible GTPase 5 - Rattus norvegicus (Rat) - Irgc gene endoplasmic reticulum membrane, GTPase activity, cellular response to interferon-beta, defense response Taurus_UMD|evm.model.AC_000175.1.746 Q2YDD2 SMG9_BOVIN 99.808 0.996161 1.00192 SMG9 - Protein SMG9 - Bos taurus (Bovine) - SMG9 gene Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (By similarity). Plays a role in brain, heart, and eye development. Taurus_UMD|evm.model.AC_000175.1.747 O15554 KCNN4_HUMAN 89.930 0.993007 1.00468 KCNN4 - Intermediate conductance calcium-activated potassium channel protein 4 - Homo sapiens (Human) - KCNN4 gene Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580). Taurus_UMD|evm.model.AC_000175.1.748 Q6UWN5 LYPD5_HUMAN 75.893 0.606557 0.729084 LYPD5 - Ly6/PLAUR domain-containing protein 5 precursor - Homo sapiens (Human) - LYPD5 gene extracellular region, plasma membrane, laminin binding, cell-matrix adhesion Taurus_UMD|evm.model.AC_000175.1.749 Q8N7M2 ZN283_HUMAN 86.623 0.996737 0.902798 ZNF283 - Zinc finger protein 283 - Homo sapiens (Human) - ZNF283 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.750 Q494X3 ZN404_HUMAN 81.670 0.981928 0.902174 ZNF404 - Zinc finger protein 404 - Homo sapiens (Human) - ZNF404 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.751 Q02386 ZNF45_HUMAN 83.504 0.992733 1.0088 ZNF45 - Zinc finger protein 45 - Homo sapiens (Human) - ZNF45 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.752 Q14588 ZN234_HUMAN 84.467 0.994109 0.97 ZNF234 - Zinc finger protein 234 - Homo sapiens (Human) - ZNF234 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.753 Q9NYT6 ZN226_HUMAN 83.011 0.875152 1.0274 ZNF226 - Zinc finger protein 226 - Homo sapiens (Human) - ZNF226 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.754 A0JNB1 ZN227_BOVIN 100.000 0.841935 0.393901 ZNF227 - Zinc finger protein 227 - Bos taurus (Bovine) - ZNF227 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.755 Q14590 ZN235_HUMAN 45.536 0.776224 0.193767 ZNF235 - Zinc finger protein 235 - Homo sapiens (Human) - ZNF235 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.756 Q14590 ZN235_HUMAN 80.544 0.588045 1.67751 ZNF235 - Zinc finger protein 235 - Homo sapiens (Human) - ZNF235 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.757 Q6UY09 CEA20_HUMAN 52.182 0.653266 1.33557 CEACAM20 - Carcinoembryonic antigen-related cell adhesion molecule 20 precursor - Homo sapiens (Human) - CEACAM20 gene Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response. Taurus_UMD|evm.model.AC_000175.1.758 Q7Z692 CEA19_HUMAN 65.033 0.275551 3.32667 CEACAM19 - Carcinoembryonic antigen-related cell adhesion molecule 19 precursor - Homo sapiens (Human) - CEACAM19 gene Taurus_UMD|evm.model.AC_000175.1.759 D3ZQE1 CEA16_RAT 90.291 0.691919 1.40426 Ceacam16 - Carcinoembryonic antigen-related cell adhesion molecule 16 precursor - Rattus norvegicus (Rat) - Ceacam16 gene Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane. Taurus_UMD|evm.model.AC_000175.1.760 P20749 BCL3_HUMAN 90.088 0.995604 1.0022 BCL3 - B-cell lymphoma 3 protein - Homo sapiens (Human) - BCL3 gene Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000175.1.761 Q9ULV8 CBLC_HUMAN 84.524 0.851626 1.03797 CBLC - E3 ubiquitin-protein ligase CBL-C - Homo sapiens (Human) - CBLC gene Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. Taurus_UMD|evm.model.AC_000175.1.762 Q9MZ08 BCAM_BOVIN 100.000 0.99682 1.00159 BCAM - Basal cell adhesion molecule precursor - Bos taurus (Bovine) - BCAM gene Laminin alpha-5 receptor. May mediate intracellular signaling (By similarity). Taurus_UMD|evm.model.AC_000175.1.763 Q92692 NECT2_HUMAN 78.189 0.996296 1.00372 NECTIN2 - Nectin-2 precursor - Homo sapiens (Human) - NECTIN2 gene Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). Taurus_UMD|evm.model.AC_000175.1.764 Q1LZB5 TOM40_BOVIN 98.093 0.994565 1.01939 TOMM40 - Mitochondrial import receptor subunit TOM40 homolog - Bos taurus (Bovine) - TOMM40 gene Channel-forming protein essential for import of protein precursors into mitochondria. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria. Taurus_UMD|evm.model.AC_000175.1.765 P0DN41 APOE_BOSMU 99.684 0.844504 1.18038 APOE - Apolipoprotein E precursor - Bos mutus grunniens (Wild yak) - APOE gene APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells. Taurus_UMD|evm.model.AC_000175.1.766 Q3SYR5 APOC4_BOVIN 100.000 0.984375 1.00787 APOC4 - Apolipoprotein C-IV precursor - Bos taurus (Bovine) - APOC4 gene May participate in lipoprotein metabolism. Taurus_UMD|evm.model.AC_000175.1.767 P19034 APOC2_BOVIN 100.000 0.980392 1.0099 APOC2 - Apolipoprotein C-II precursor - Bos taurus (Bovine) - APOC2 gene Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. Taurus_UMD|evm.model.AC_000175.1.768 Q2NL17 CLPT1_BOVIN 100.000 0.766513 0.971642 CLPTM1 - Cleft lip and palate transmembrane protein 1 homolog - Bos taurus (Bovine) - CLPTM1 gene May play a role in T-cell development. Taurus_UMD|evm.model.AC_000175.1.769 Q01201 RELB_HUMAN 91.667 0.996454 0.974093 RELB - Transcription factor RelB - Homo sapiens (Human) - RELB gene NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). Taurus_UMD|evm.model.AC_000175.1.770 A0JNI5 CLASR_BOVIN 100.000 0.997019 1.00149 CLASRP - CLK4-associating serine/arginine rich protein - Bos taurus (Bovine) - CLASRP gene Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). Taurus_UMD|evm.model.AC_000175.1.771 Q8WUU4 ZN296_HUMAN 77.987 0.995789 1 ZNF296 - Zinc finger protein 296 - Homo sapiens (Human) - ZNF296 gene May be a transcriptional corepressor with KLF4. Taurus_UMD|evm.model.AC_000175.1.772 Q17QA0 GEMI7_BOVIN 100.000 0.984127 1.008 GEMIN7 - Gem-associated protein 7 - Bos taurus (Bovine) - GEMIN7 gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity). Taurus_UMD|evm.model.AC_000175.1.773 A7Z026 PPR37_BOVIN 100.000 0.997143 1.00143 PPP1R37 - Protein phosphatase 1 regulatory subunit 37 - Bos taurus (Bovine) - PPP1R37 gene Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. Taurus_UMD|evm.model.AC_000175.1.774 Q17RQ9 NKPD1_HUMAN 85.406 0.723764 1.35902 NKPD1 - NTPase KAP family P-loop domain-containing protein 1 - Homo sapiens (Human) - NKPD1 gene Taurus_UMD|evm.model.AC_000175.1.775 Q3T086 TPC6A_BOVIN 100.000 0.9875 1.00629 TRAPPC6A - Trafficking protein particle complex subunit 6A - Bos taurus (Bovine) - TRAPPC6A gene May play a role in vesicular transport during the biogenesis of melanosomes. Taurus_UMD|evm.model.AC_000175.1.776 A5PJP1 BL1S3_BOVIN 100.000 0.99005 1.005 BLOC1S3 - Biogenesis of lysosome-related organelles complex 1 subunit 3 - Bos taurus (Bovine) - BLOC1S3 gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking (By similarity). Taurus_UMD|evm.model.AC_000175.1.777 Q5XG41 DH12A_XENLA 51.037 0.756329 0.993711 hsd17b12-a - Very-long-chain 3-oxoacyl-CoA reductase-A - Xenopus laevis (African clawed frog) - hsd17b12-a gene Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. Taurus_UMD|evm.model.AC_000175.1.778 Q2M3D2 EX3L2_HUMAN 87.864 0.616085 1.61125 EXOC3L2 - Exocyst complex component 3-like protein 2 - Homo sapiens (Human) - EXOC3L2 gene exocyst, SNARE binding, exocyst localization, exocytosis Taurus_UMD|evm.model.AC_000175.1.779 Q96L34 MARK4_HUMAN 91.837 0.97139 0.976064 MARK4 - MAP/microtubule affinity-regulating kinase 4 - Homo sapiens (Human) - MARK4 gene Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Taurus_UMD|evm.model.AC_000175.1.780 Q9XSC6 KCRM_BOVIN 100.000 0.994764 1.00262 CKM - Creatine kinase M-type - Bos taurus (Bovine) - CKM gene Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). Taurus_UMD|evm.model.AC_000175.1.781 Q2TBQ9 KLC3_BOVIN 99.802 0.870466 1.14653 KLC3 - Kinesin light chain 3 - Bos taurus (Bovine) - KLC3 gene Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Taurus_UMD|evm.model.AC_000175.1.782 A6QLJ0 ERCC2_BOVIN 99.868 0.442499 2.25395 ERCC2 - General transcription and DNA repair factor IIH helicase subunit XPD - Bos taurus (Bovine) - ERCC2 gene ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers. Taurus_UMD|evm.model.AC_000175.1.783 O15446 RPA34_HUMAN 65.779 0.971857 1.0451 POLR1G - DNA-directed RNA polymerase I subunit RPA34 - Homo sapiens (Human) - POLR1G gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation. Taurus_UMD|evm.model.AC_000175.1.784 Q1LZ75 ERCC1_BOVIN 100.000 0.755155 1.31973 ERCC1 - DNA excision repair protein ERCC-1 - Bos taurus (Bovine) - ERCC1 gene Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). Taurus_UMD|evm.model.AC_000175.1.785 P53539 FOSB_HUMAN 97.947 0.994152 1.01183 FOSB - Protein fosB - Homo sapiens (Human) - FOSB gene FosB interacts with Jun proteins enhancing their DNA binding activity. Taurus_UMD|evm.model.AC_000175.1.786 Q6WN19 RTN2_RAT 81.741 0.995754 1.00426 Rtn2 - Reticulon-2 - Rattus norvegicus (Rat) - Rtn2 gene Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity (By similarity). Enhances trafficking of the glutamate transporter SLC1A1/EAAC1 from the endoplasmic reticulum to the cell surface (PubMed:18096700). Plays a role in the translocation of SLC2A4/GLUT4 from intracellular membranes to the cell membrane which facilitates the uptake of glucose into the cell (By similarity). Taurus_UMD|evm.model.AC_000175.1.787 Q8N819 PPM1N_HUMAN 81.975 0.972973 0.946512 PPM1N - Probable protein phosphatase 1N - Homo sapiens (Human) - PPM1N gene cytosol, nucleus, negative regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of canonical Wnt signaling pathway Taurus_UMD|evm.model.AC_000175.1.788 Q2TA49 VASP_BOVIN 100.000 0.994792 1.00261 VASP - Vasodilator-stimulated phosphoprotein - Bos taurus (Bovine) - VASP gene Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity). Taurus_UMD|evm.model.AC_000175.1.789 Q05B66 OPA3_BOVIN 100.000 0.985612 0.727749 OPA3 - Optic atrophy 3 protein homolog - Bos taurus (Bovine) - OPA3 gene May play some role in mitochondrial processes. Taurus_UMD|evm.model.AC_000175.1.791 Q9H6K4 OPA3_HUMAN 84.324 0.983957 1.04469 OPA3 - Optic atrophy 3 protein - Homo sapiens (Human) - OPA3 gene May play some role in mitochondrial processes. Taurus_UMD|evm.model.AC_000175.1.792 Q1JQB3 GPR4_BOVIN 100.000 0.99449 1.00276 GPR4 - G-protein coupled receptor 4 - Bos taurus (Bovine) - GPR4 gene Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA13/Rho pathways. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway. In the brain may mediate central respiratory sensitivity to CO(2)/H(+). Taurus_UMD|evm.model.AC_000175.1.793 O95834 EMAL2_HUMAN 95.963 0.702732 1.40986 EML2 - Echinoderm microtubule-associated protein-like 2 - Homo sapiens (Human) - EML2 gene Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules. Taurus_UMD|evm.model.AC_000175.1.794 P48546 GIPR_HUMAN 81.684 0.951807 1.06867 GIPR - Gastric inhibitory polypeptide receptor precursor - Homo sapiens (Human) - GIPR gene This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Taurus_UMD|evm.model.AC_000175.1.795 P62317 SMD2_MOUSE 100.000 0.846715 1.16102 Snrpd2 - Small nuclear ribonucleoprotein Sm D2 - Mus musculus (Mouse) - Snrpd2 gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. Taurus_UMD|evm.model.AC_000175.1.796 Q0V8G3 QPCTL_BOVIN 100.000 0.994792 1.00261 QPCTL - Glutaminyl-peptide cyclotransferase-like protein - Bos taurus (Bovine) - QPCTL gene Responsible for the biosynthesis of pyroglutamyl peptides. Taurus_UMD|evm.model.AC_000175.1.797 Q86VE0 MYPOP_HUMAN 95.484 0.157303 2.45363 MYPOP - Myb-related transcription factor, partner of profilin - Homo sapiens (Human) - MYPOP gene Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity). Taurus_UMD|evm.model.AC_000175.1.798 C9JSJ3 MEIOS_HUMAN 66.290 0.843902 0.96395 MEIOSIN - Meiosis initiator protein - Homo sapiens (Human) - MEIOSIN gene Gatekeeper of meiotic initiation in both male and female germ cells. In complex with STRA8, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis. Temporal expression of MEIOSIN is required for meiotic entry decision. Taurus_UMD|evm.model.AC_000175.1.799 Q8N196 SIX5_HUMAN 90.013 0.997294 1 SIX5 - Homeobox protein SIX5 - Homo sapiens (Human) - SIX5 gene Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity). Taurus_UMD|evm.model.AC_000175.1.800 Q09013 DMPK_HUMAN 90.630 0.996769 0.984102 DMPK - Myotonin-protein kinase - Homo sapiens (Human) - DMPK gene Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. Taurus_UMD|evm.model.AC_000175.1.801 Q09019 DMWD_HUMAN 97.033 0.997024 0.997033 DMWD - Dystrophia myotonica WD repeat-containing protein - Homo sapiens (Human) - DMWD gene Taurus_UMD|evm.model.AC_000175.1.802 Q9H0K4 RSH6A_HUMAN 76.060 0.997207 0.998605 RSPH6A - Radial spoke head protein 6 homolog A - Homo sapiens (Human) - RSPH6A gene Essential for sperm flagellar assembly and male fertility. Taurus_UMD|evm.model.AC_000175.1.803 Q92797 SYMPK_HUMAN 96.546 0.998429 0.999215 SYMPK - Symplekin - Homo sapiens (Human) - SYMPK gene Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. Taurus_UMD|evm.model.AC_000175.1.805 Q3Y598 FOXA3_BOVIN 100.000 0.994318 1.00285 FOXA3 - Hepatocyte nuclear factor 3-gamma - Bos taurus (Bovine) - FOXA3 gene Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes (By similarity). Taurus_UMD|evm.model.AC_000175.1.806 P60321 NANO2_HUMAN 86.957 0.985612 1.00725 NANOS2 - Nanos homolog 2 - Homo sapiens (Human) - NANOS2 gene Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity). Taurus_UMD|evm.model.AC_000175.1.807 Q9UNW9 NOVA2_HUMAN 100.000 0.968619 0.971545 NOVA2 - RNA-binding protein Nova-2 - Homo sapiens (Human) - NOVA2 gene May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA. Taurus_UMD|evm.model.AC_000175.1.808 Q9Y6R9 CCD61_HUMAN 89.105 0.996101 1.00195 CCDC61 - Centrosomal protein CCDC61 - Homo sapiens (Human) - CCDC61 gene Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023). Taurus_UMD|evm.model.AC_000175.1.809 Q8SPP7 PGRP1_BOVIN 100.000 0.989529 1.00526 PGLYRP1 - Peptidoglycan recognition protein 1 precursor - Bos taurus (Bovine) - PGLYRP1 gene Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity (PubMed:11880375, PubMed:16394004). Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor (By similarity). Taurus_UMD|evm.model.AC_000175.1.810 P13696 PEBP1_BOVIN 94.118 0.989362 1.00535 PEBP1 - Phosphatidylethanolamine-binding protein 1 - Bos taurus (Bovine) - PEBP1 gene Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity). Taurus_UMD|evm.model.AC_000175.1.811 Q6UW32 IGFL1_HUMAN 63.248 0.983051 1.07273 IGFL1 - Insulin growth factor-like family member 1 precursor - Homo sapiens (Human) - IGFL1 gene Probable ligand of the IGFLR1 cell membrane receptor. Taurus_UMD|evm.model.AC_000175.1.812 Q9Y2N7 HIF3A_HUMAN 88.640 0.997015 1.00149 HIF3A - Hypoxia-inducible factor 3-alpha - Homo sapiens (Human) - HIF3A gene Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity). Taurus_UMD|evm.model.AC_000175.1.813 P53041 PPP5_HUMAN 97.395 0.996 1.002 PPP5C - Serine/threonine-protein phosphatase 5 - Homo sapiens (Human) - PPP5C gene Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:9000529, PubMed:30699359). Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:9000529, PubMed:30699359). Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (PubMed:14871926, PubMed:16260606, PubMed:21144835). Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (PubMed:23102700). Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function (By similarity). Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 (By similarity). Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E (PubMed:16790549). May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels (PubMed:22781750). Dephosphorylates and may play a role in the regulation of TAU/MAPT (PubMed:15546861). Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 (By similarity). Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (PubMed:30699359). Taurus_UMD|evm.model.AC_000175.1.814 A7E321 PNM8A_BOVIN 100.000 0.995763 1.00212 PNMA8A - Paraneoplastic antigen-like protein 8A - Bos taurus (Bovine) - PNMA8A gene Taurus_UMD|evm.model.AC_000175.1.815 A0A1B0GUJ8 PNM8C_HUMAN 82.143 0.0315789 4.19118 PNMA8C - Paraneoplastic antigen-like protein 8C - Homo sapiens (Human) - PNMA8C gene Taurus_UMD|evm.model.AC_000175.1.816 Q9ULN7 PNM8B_HUMAN 60.377 0.351351 0.233071 PNMA8B - Paraneoplastic antigen-like protein 8B - Homo sapiens (Human) - PNMA8B gene Taurus_UMD|evm.model.AC_000175.1.817 P0DP31 CALM3_RAT 100.000 0.986667 1.00671 Calm3 - Calmodulin-3 - Rattus norvegicus (Rat) - Calm3 gene Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Taurus_UMD|evm.model.AC_000175.1.818 P79393 PI2R_BOVIN 97.409 0.994805 1 PTGIR - Prostacyclin receptor precursor - Bos taurus (Bovine) - PTGIR gene Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. Taurus_UMD|evm.model.AC_000175.1.819 Q9UK08 GBG8_HUMAN 100.000 0.971831 1.01429 GNG8 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 precursor - Homo sapiens (Human) - GNG8 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Taurus_UMD|evm.model.AC_000175.1.820 Q96B18 DACT3_HUMAN 94.855 0.651261 0.756757 DACT3 - Dapper homolog 3 - Homo sapiens (Human) - DACT3 gene May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Taurus_UMD|evm.model.AC_000175.1.821 Q9BZL6 KPCD2_HUMAN 96.113 0.996475 0.969248 PRKD2 - Serine/threonine-protein kinase D2 - Homo sapiens (Human) - PRKD2 gene Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:15604256, PubMed:14743217, PubMed:17077180, PubMed:16928771, PubMed:17962809, PubMed:17951978, PubMed:18262756, PubMed:19192391, PubMed:19001381, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). Taurus_UMD|evm.model.AC_000175.1.822 P58404 STRN4_MOUSE 92.741 0.960114 0.923684 Strn4 - Striatin-4 - Mus musculus (Mouse) - Strn4 gene Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. Taurus_UMD|evm.model.AC_000175.1.823 Q9H9S5 FKRP_HUMAN 93.927 0.993952 1.00202 FKRP - Fukutin-related protein - Homo sapiens (Human) - FKRP gene Catalyzes the transfer of CDP-ribitol to ribitol 5-phosphate previously attached by FKTN/fukutin of to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:25279699, PubMed:26923585, PubMed:29477842). This constitutes the second step in the formation of the ribose 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (PubMed:25279699, PubMed:26923585, PubMed:29477842). Taurus_UMD|evm.model.AC_000175.1.824 Q95JC7 AAAT_BOVIN 99.814 0.996296 1.00186 SLC1A5 - Neutral amino acid transporter B(0) - Bos taurus (Bovine) - SLC1A5 gene Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. Taurus_UMD|evm.model.AC_000175.1.825 P62744 AP2S1_RAT 100.000 0.986014 1.00704 Ap2s1 - AP-2 complex subunit sigma - Rattus norvegicus (Rat) - Ap2s1 gene Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. May also play a role in extracellular calcium homeostasis (By similarity). Taurus_UMD|evm.model.AC_000175.1.826 P83509 RHG35_CANLF 98.533 0.998668 1.00067 ARHGAP35 - Rho GTPase-activating protein 35 - Canis lupus familiaris (Dog) - ARHGAP35 gene Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (By similarity). Taurus_UMD|evm.model.AC_000175.1.827 Q99742 NPAS1_HUMAN 87.879 0.931638 1.0661 NPAS1 - Neuronal PAS domain-containing protein 1 - Homo sapiens (Human) - NPAS1 gene May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity). Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (By similarity). Taurus_UMD|evm.model.AC_000175.1.828 Q24JY6 TM160_BOVIN 100.000 0.989418 1.00532 TMEM160 - Transmembrane protein 160 - Bos taurus (Bovine) - TMEM160 gene Taurus_UMD|evm.model.AC_000175.1.829 Q9UPT8 ZC3H4_HUMAN 90.698 0.972769 1.01458 ZC3H4 - Zinc finger CCCH domain-containing protein 4 - Homo sapiens (Human) - ZC3H4 gene cytosol, nucleoplasm, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA binding Taurus_UMD|evm.model.AC_000175.1.830 A2VE14 SAE1_BOVIN 100.000 0.994236 1.00289 SAE1 - SUMO-activating enzyme subunit 1 - Bos taurus (Bovine) - SAE1 gene The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity). Taurus_UMD|evm.model.AC_000175.1.831 Q9BXH1 BBC3_HUMAN 90.099 0.833333 0.621762 BBC3 - Bcl-2-binding component 3, isoforms 1/2 - Homo sapiens (Human) - BBC3 gene Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391). Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis (PubMed:23340338). Taurus_UMD|evm.model.AC_000175.1.832 Q9Y3X0 CCDC9_HUMAN 80.303 0.905594 1.07721 CCDC9 - Coiled-coil domain-containing protein 9 - Homo sapiens (Human) - CCDC9 gene RNA binding Taurus_UMD|evm.model.AC_000175.1.833 P79175 C5AR1_GORGO 72.334 0.985714 1 C5AR1 - C5a anaphylatoxin chemotactic receptor 1 - Gorilla gorilla gorilla (Western lowland gorilla) - C5AR1 gene Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Taurus_UMD|evm.model.AC_000175.1.834 Q9P296 C5AR2_HUMAN 76.261 0.994083 1.00297 C5AR2 - C5a anaphylatoxin chemotactic receptor 2 - Homo sapiens (Human) - C5AR2 gene Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. Taurus_UMD|evm.model.AC_000175.1.835 Q14147 DHX34_HUMAN 88.482 0.998256 1.0035 DHX34 - Probable ATP-dependent RNA helicase DHX34 - Homo sapiens (Human) - DHX34 gene Probable ATP-binding RNA helicase. Taurus_UMD|evm.model.AC_000175.1.836 Q99687 MEIS3_HUMAN 92.857 0.994695 1.00533 MEIS3 - Homeobox protein Meis3 - Homo sapiens (Human) - MEIS3 gene Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG1. Taurus_UMD|evm.model.AC_000175.1.837 Q9UPR5 NAC2_HUMAN 97.939 0.68071 1.46906 SLC8A2 - Sodium/calcium exchanger 2 precursor - Homo sapiens (Human) - SLC8A2 gene Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion. Taurus_UMD|evm.model.AC_000175.1.838 P54920 SNAA_HUMAN 98.983 0.993243 1.00339 NAPA - Alpha-soluble NSF attachment protein - Homo sapiens (Human) - NAPA gene Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). Taurus_UMD|evm.model.AC_000175.1.839 Q4R2Z8 ZN541_MACFA 81.158 0.598513 1.67289 ZNF541 - Zinc finger protein 541 - Macaca fascicularis (Crab-eating macaque) - ZNF541 gene Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis. Taurus_UMD|evm.model.AC_000175.1.841 F8VPZ9 BICRA_MOUSE 88.472 0.472991 0.961977 Bicra - BRD4-interacting chromatin-remodeling complex-associated protein - Mus musculus (Mouse) - Bicra gene Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (By similarity). Taurus_UMD|evm.model.AC_000175.1.842 Q9NZN4 EHD2_HUMAN 98.711 0.996324 1.00184 EHD2 - EH domain-containing protein 2 - Homo sapiens (Human) - EHD2 gene ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (PubMed:25588833). Taurus_UMD|evm.model.AC_000175.1.843 Q9NZM5 NOP53_HUMAN 84.091 0.928846 1.08787 NOP53 - Ribosome biogenesis protein NOP53 - Homo sapiens (Human) - NOP53 gene Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of DDX58/RIG-1 (PubMed:27824081). Taurus_UMD|evm.model.AC_000175.1.844 O19097 SELW_SHEEP 87.356 0.974026 0.885057 SELENOW - Selenoprotein W - Ovis aries (Sheep) - SELENOW gene Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity). Taurus_UMD|evm.model.AC_000175.1.845 O15499 GSC2_HUMAN 56.140 0.216216 1.26341 GSC2 - Homeobox protein goosecoid-2 - Homo sapiens (Human) - GSC2 gene May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC. Taurus_UMD|evm.model.AC_000175.1.846 Q9XSK0 CRX_BOVIN 100.000 0.993333 1.00334 CRX - Cone-rod homeobox protein - Bos taurus (Bovine) - CRX gene Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors (By similarity). Taurus_UMD|evm.model.AC_000175.1.847 O15499 GSC2_HUMAN 54.386 0.243478 1.12195 GSC2 - Homeobox protein goosecoid-2 - Homo sapiens (Human) - GSC2 gene May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC. Taurus_UMD|evm.model.AC_000175.1.848 P52842 ST2A1_MACFA 74.035 0.993007 1.00351 SULT2A1 - Sulfotransferase 2A1 - Macaca fascicularis (Crab-eating macaque) - SULT2A1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed:31100221). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism (By similarity). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity). Taurus_UMD|evm.model.AC_000175.1.849 P52842 ST2A1_MACFA 73.091 0.553535 1.73684 SULT2A1 - Sulfotransferase 2A1 - Macaca fascicularis (Crab-eating macaque) - SULT2A1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed:31100221). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism (By similarity). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity). Taurus_UMD|evm.model.AC_000175.1.850 Q7YR83 ESPB1_PIG 83.408 0.991071 1.00448 ELSPBP1 - Epididymal sperm-binding protein 1 precursor - Sus scrofa (Pig) - ELSPBP1 gene Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity. Taurus_UMD|evm.model.AC_000175.1.851 Q9N1Q8 CABP5_BOVIN 95.954 0.886598 1.12139 CABP5 - Calcium-binding protein 5 - Bos taurus (Bovine) - CABP5 gene Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials (By similarity). Involved in the transmission of light signals (By similarity). May positively regulate neurotransmitter vesicle endocytosis and exocytosis in a salt-dependent manner (By similarity). May play a role in the extension and network organization of neurites (By similarity). Taurus_UMD|evm.model.AC_000175.1.852 P18858 DNLI1_HUMAN 84.022 0.954119 1.04353 LIG1 - DNA ligase 1 - Homo sapiens (Human) - LIG1 gene DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Taurus_UMD|evm.model.AC_000175.1.853 Q86XI8 ZSWM9_HUMAN 90.939 0.668838 1.4689 ZSWIM9 - Uncharacterized protein ZSWIM9 - Homo sapiens (Human) - ZSWIM9 gene Taurus_UMD|evm.model.AC_000175.1.854 Q8IZ26 ZNF34_HUMAN 46.512 0.742574 0.721429 ZNF34 - Zinc finger protein 34 - Homo sapiens (Human) - ZNF34 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.855 Q9EQ46 V1R40_MOUSE 39.189 0.864706 0.548387 Vmn1r40 - Vomeronasal type-1 receptor 40 - Mus musculus (Mouse) - Vmn1r40 gene Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Taurus_UMD|evm.model.AC_000175.1.857 Q96M63 ODAD1_HUMAN 60.294 0.93695 1.01791 ODAD1 - Outer dynein arm-docking complex subunit 1 - Homo sapiens (Human) - ODAD1 gene Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Taurus_UMD|evm.model.AC_000175.1.858 Q58DR6 EMP3_BOVIN 100.000 0.987805 1.00613 EMP3 - Epithelial membrane protein 3 - Bos taurus (Bovine) - EMP3 gene Probably involved in cell proliferation and cell-cell interactions. Taurus_UMD|evm.model.AC_000175.1.859 Q32PH2 TM143_BOVIN 99.782 0.995643 1.00438 TMEM143 - Transmembrane protein 143 - Bos taurus (Bovine) - TMEM143 gene mitochondrion Taurus_UMD|evm.model.AC_000175.1.860 Q2YDD6 SNG4_BOVIN 99.573 0.991489 1.00427 SYNGR4 - Synaptogyrin-4 - Bos taurus (Bovine) - SYNGR4 gene Taurus_UMD|evm.model.AC_000175.1.861 P33946 ERD21_BOVIN 100.000 0.99061 1.00472 KDELR1 - ER lumen protein-retaining receptor 1 - Bos taurus (Bovine) - KDELR1 gene Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. Taurus_UMD|evm.model.AC_000175.1.862 O15399 NMDE4_HUMAN 99.231 0.812304 0.717814 GRIN2D - Glutamate receptor ionotropic, NMDA 2D precursor - Homo sapiens (Human) - GRIN2D gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750). Taurus_UMD|evm.model.AC_000175.1.863 Q1JQD2 GRWD1_BOVIN 100.000 0.995526 1.00224 GRWD1 - Glutamate-rich WD repeat-containing protein 1 - Bos taurus (Bovine) - GRWD1 gene Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness. Taurus_UMD|evm.model.AC_000175.1.865 Q9UNX9 KCJ14_HUMAN 94.266 0.995402 0.997706 KCNJ14 - ATP-sensitive inward rectifier potassium channel 14 - Homo sapiens (Human) - KCNJ14 gene Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity). Taurus_UMD|evm.model.AC_000175.1.866 Q76MY7 CYH2_CHLAE 100.000 0.995 1.00251 CYTH2 - Cytohesin-2 - Chlorocebus aethiops (Green monkey) - CYTH2 gene Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity). Taurus_UMD|evm.model.AC_000175.1.867 Q96Q04 LMTK3_HUMAN 88.881 0.980282 0.972603 LMTK3 - Serine/threonine-protein kinase LMTK3 precursor - Homo sapiens (Human) - LMTK3 gene Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity). Taurus_UMD|evm.model.AC_000175.1.868 O00204 ST2B1_HUMAN 71.246 0.909385 0.846575 SULT2B1 - Sulfotransferase 2B1 - Homo sapiens (Human) - SULT2B1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:19589875, PubMed:12145317). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:9799594, PubMed:12145317, PubMed:21855633, PubMed:16855051). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648). Taurus_UMD|evm.model.AC_000175.1.869 Q2M2I3 FA83E_HUMAN 76.411 0.99 1.04603 FAM83E - Protein FAM83E - Homo sapiens (Human) - FAM83E gene May play a role in MAPK signaling. Taurus_UMD|evm.model.AC_000175.1.870 Q5E973 RL18_BOVIN 100.000 0.989418 1.00532 RPL18 - 60S ribosomal protein L18 - Bos taurus (Bovine) - RPL18 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000175.1.871 Q9NRA0 SPHK2_HUMAN 87.227 0.832865 1.08869 SPHK2 - Sphingosine kinase 2 - Homo sapiens (Human) - SPHK2 gene Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:19168031, PubMed:12954646). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Upregulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). Taurus_UMD|evm.model.AC_000175.1.872 Q32PF6 DBP_BOVIN 100.000 0.993865 1.00308 DBP - D site-binding protein - Bos taurus (Bovine) - DBP gene This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation (By similarity). Taurus_UMD|evm.model.AC_000175.1.873 Q866X7 CAH11_BOVIN 83.841 0.992982 0.868902 CA11 - Carbonic anhydrase-related protein 11 precursor - Bos taurus (Bovine) - CA11 gene Does not have a catalytic activity. Taurus_UMD|evm.model.AC_000175.1.874 Q8WTR8 NET5_HUMAN 85.041 0.993878 1.00204 NTN5 - Netrin-5 precursor - Homo sapiens (Human) - NTN5 gene Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube. Taurus_UMD|evm.model.AC_000175.1.875 Q9TTY3 SEC1_BOVIN 99.728 0.99458 1.00272 SEC1 - Galactoside 2-alpha-L-fucosyltransferase SEC1 - Bos taurus (Bovine) - SEC1 gene Catalyzes the transfer of alpha 1,2-linked fucose to ganglioside GM1 and galacto-N-biose. Taurus_UMD|evm.model.AC_000175.1.876 Q28113 FUT2_BOVIN 99.128 0.994203 1.00291 FUT2 - Galactoside alpha-(1,2)-fucosyltransferase 2 - Bos taurus (Bovine) - FUT2 gene Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:10814703). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (By similarity). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:20506485). Taurus_UMD|evm.model.AC_000175.1.877 A7E346 MASTR_BOVIN 100.000 0.99536 1.00233 MAMSTR - MEF2-activating motif and SAP domain-containing transcriptional regulator - Bos taurus (Bovine) - MAMSTR gene Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation (By similarity). Taurus_UMD|evm.model.AC_000175.1.878 Q5U651 RAIN_HUMAN 97.300 0.997925 1.00104 RASIP1 - Ras-interacting protein 1 - Homo sapiens (Human) - RASIP1 gene Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. Taurus_UMD|evm.model.AC_000175.1.879 Q8IYV9 IZUM1_HUMAN 65.130 0.994236 0.991429 IZUMO1 - Izumo sperm-egg fusion protein 1 precursor - Homo sapiens (Human) - IZUMO1 gene Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg (PubMed:15759005). The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:15759005). The ligand-receptor interaction probably does not act as a membrane 'fusogen' (PubMed:15759005). Taurus_UMD|evm.model.AC_000175.1.880 F6Q1T7 FUT1_BOVIN 99.167 0.860911 1.15833 FUT1 - Galactoside alpha-(1,2)-fucosyltransferase 1 - Bos taurus (Bovine) - FUT1 gene Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens (PubMed:10814703). H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (By similarity). Preferentially fucosylates soluble lactose and to a lesser extent, fucosylates glycolipids gangliosides GA1 and GM1a (PubMed:10814703). Taurus_UMD|evm.model.AC_000175.1.881 Q9NSA1 FGF21_HUMAN 84.689 0.990476 1.00478 FGF21 - Fibroblast growth factor 21 precursor - Homo sapiens (Human) - FGF21 gene Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Taurus_UMD|evm.model.AC_000175.1.882 Q5EA40 BCAT2_BOVIN 100.000 0.994924 1.00254 BCAT2 - Branched-chain-amino-acid aminotransferase, mitochondrial precursor - Bos taurus (Bovine) - BCAT2 gene Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). Taurus_UMD|evm.model.AC_000175.1.883 Q9MYP6 DHB14_BOVIN 100.000 0.99262 1.0037 HSD17B14 - 17-beta-hydroxysteroid dehydrogenase 14 - Bos taurus (Bovine) - HSD17B14 gene Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro). Taurus_UMD|evm.model.AC_000175.1.884 Q9H4M7 PKHA4_HUMAN 87.051 0.997439 1.00257 PLEKHA4 - Pleckstrin homology domain-containing family A member 4 - Homo sapiens (Human) - PLEKHA4 gene Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. Taurus_UMD|evm.model.AC_000175.1.885 Q2KI51 PR15A_BOVIN 99.851 0.997019 1.00149 PPP1R15A - Protein phosphatase 1 regulatory subunit 15A - Bos taurus (Bovine) - PPP1R15A gene Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15' (By similarity). Taurus_UMD|evm.model.AC_000175.1.886 O00294 TULP1_HUMAN 63.396 0.501908 0.96679 TULP1 - Tubby-related protein 1 - Homo sapiens (Human) - TULP1 gene Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. Taurus_UMD|evm.model.AC_000175.1.887 Q0P569 NUCB1_BOVIN 96.414 0.995633 0.966245 NUCB1 - Nucleobindin-1 precursor - Bos taurus (Bovine) - NUCB1 gene Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (PubMed:7890746). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). Taurus_UMD|evm.model.AC_000175.1.888 Q148L6 DHDH_BOVIN 100.000 0.994048 1.00299 DHDH - Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase - Bos taurus (Bovine) - DHDH gene D-xylose 1-dehydrogenase (NADP+) activity, D-xylose catabolic process Taurus_UMD|evm.model.AC_000175.1.889 O02703 BAX_BOVIN 99.451 0.93299 1.01042 BAX - Apoptosis regulator BAX - Bos taurus (Bovine) - BAX gene Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production (By similarity). Interacts (via a C-terminal 33 residues) with NOL3 (via CARD domain); inhibits BAX activation and translocation and consequently cytochrome c release from mitochondria (By similarity). Taurus_UMD|evm.model.AC_000175.1.890 O46415 FRIL_BOVIN 100.000 0.988636 1.00571 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000175.1.891 A7MB78 GYS1_BOVIN 100.000 0.997286 1.00136 GYS1 - Glycogen [starch] synthase, muscle - Bos taurus (Bovine) - GYS1 gene Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Taurus_UMD|evm.model.AC_000175.1.892 Q9Y230 RUVB2_HUMAN 99.784 0.99569 1.00216 RUVBL2 - RuvB-like 2 - Homo sapiens (Human) - RUVBL2 gene Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). Taurus_UMD|evm.model.AC_000175.1.893 P04651 LSHB_BOVIN 100.000 0.985915 1.00709 LHB - Lutropin subunit beta precursor - Bos taurus (Bovine) - LHB gene Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. Taurus_UMD|evm.model.AC_000175.1.895 Q80VU4 NTF4_MOUSE 92.746 0.909953 1.00957 Ntf4 - Neurotrophin-4 precursor - Mus musculus (Mouse) - Ntf4 gene Could serve as a target-derived trophic factor for sensory and sympathetic neurons. Taurus_UMD|evm.model.AC_000175.1.896 Q17ST2 KCNA7_MOUSE 93.002 0.964989 0.93456 Kcna7 - Potassium voltage-gated channel subfamily A member 7 - Mus musculus (Mouse) - Kcna7 gene Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channels formed by isoform 1 inactivate faster than channels formed by isoform 2. Taurus_UMD|evm.model.AC_000175.1.897 Q1RMR2 RU17_BOVIN 100.000 0.995455 1.00228 SNRNP70 - U1 small nuclear ribonucleoprotein 70 kDa - Bos taurus (Bovine) - SNRNP70 gene Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. Taurus_UMD|evm.model.AC_000175.1.898 Q2KIB6 LIN7B_BOVIN 100.000 0.961538 1.03483 LIN7B - Protein lin-7 homolog B - Bos taurus (Bovine) - LIN7B gene Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). Taurus_UMD|evm.model.AC_000175.1.899 O75145 LIPA3_HUMAN 99.162 0.998326 1.00084 PPFIA3 - Liprin-alpha-3 - Homo sapiens (Human) - PPFIA3 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000175.1.900 P23327 SRCH_HUMAN 59.029 0.723624 1.2475 HRC - Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor - Homo sapiens (Human) - HRC gene May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. Taurus_UMD|evm.model.AC_000175.1.901 Q7TN37 TRPM4_MOUSE 81.750 0.983444 0.995878 Trpm4 - Transient receptor potential cation channel subfamily M member 4 - Mus musculus (Mouse) - Trpm4 gene Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:17188667, PubMed:29211714). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway (By similarity). Essential for the migration but not the maturation of dendritic cells (PubMed:18758465). Plays a role in keratinocyte differentiation (By similarity). Taurus_UMD|evm.model.AC_000175.1.902 Q9GZN6 S6A16_HUMAN 37.871 0.761333 1.01902 SLC6A16 - Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 - Homo sapiens (Human) - SLC6A16 gene integral component of plasma membrane, neurotransmitter transmembrane transporter activity, neurotransmitter transport, sodium ion transmembrane transport Taurus_UMD|evm.model.AC_000175.1.903 Q9GZN6 S6A16_HUMAN 45.758 0.976257 0.972826 SLC6A16 - Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 - Homo sapiens (Human) - SLC6A16 gene integral component of plasma membrane, neurotransmitter transmembrane transporter activity, neurotransmitter transport, sodium ion transmembrane transport Taurus_UMD|evm.model.AC_000175.1.904 Q9GZN6 S6A16_HUMAN 57.766 0.926209 1.06793 SLC6A16 - Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 - Homo sapiens (Human) - SLC6A16 gene integral component of plasma membrane, neurotransmitter transmembrane transporter activity, neurotransmitter transport, sodium ion transmembrane transport Taurus_UMD|evm.model.AC_000175.1.905 P62828 RAN_RAT 88.793 0.982906 0.541667 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Taurus_UMD|evm.model.AC_000175.1.906 Q2KHY8 CD37_BOVIN 100.000 0.917763 1.08571 CD37 - Leukocyte antigen CD37 - Bos taurus (Bovine) - CD37 gene integral component of plasma membrane Taurus_UMD|evm.model.AC_000175.1.907 Q15562 TEAD2_HUMAN 96.026 0.995575 1.01119 TEAD2 - Transcriptional enhancer factor TEF-4 - Homo sapiens (Human) - TEAD2 gene Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. Taurus_UMD|evm.model.AC_000175.1.908 Q9UK85 DKKL1_HUMAN 77.778 0.918803 0.966942 DKKL1 - Dickkopf-like protein 1 precursor - Homo sapiens (Human) - DKKL1 gene Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility. Taurus_UMD|evm.model.AC_000175.1.909 Q2T9R2 KASH5_BOVIN 92.756 0.912763 1.17905 KASH5 - Protein KASH5 - Bos taurus (Bovine) - KASH5 gene As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation. Taurus_UMD|evm.model.AC_000175.1.910 Q96A98 TIP39_HUMAN 85.000 0.979798 0.99 PTH2 - Tuberoinfundibular peptide of 39 residues precursor - Homo sapiens (Human) - PTH2 gene Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. Taurus_UMD|evm.model.AC_000175.1.911 I3L273 GFY_HUMAN 61.552 0.996448 1.08687 GFY - Golgi-associated olfactory signaling regulator precursor - Homo sapiens (Human) - GFY gene Required for proper function of the olfactory system. May be involved in establishing the acuity of olfactory sensory signaling (By similarity). Taurus_UMD|evm.model.AC_000175.1.912 A4FV52 VGLU1_BOVIN 100.000 0.996435 1.00179 SLC17A7 - Vesicular glutamate transporter 1 - Bos taurus (Bovine) - SLC17A7 gene Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate (By similarity). Taurus_UMD|evm.model.AC_000175.1.913 Q0VCI6 PIHD1_BOVIN 99.655 0.993127 1.00345 PIH1D1 - PIH1 domain-containing protein 1 - Bos taurus (Bovine) - PIH1D1 gene Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (By similarity). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity). Positively regulates the assembly and activity of the mTORC1 complex (By similarity). Taurus_UMD|evm.model.AC_000175.1.914 A6QR56 A16A1_BOVIN 95.500 0.997423 0.97 ALDH16A1 - Aldehyde dehydrogenase family 16 member A1 - Bos taurus (Bovine) - ALDH16A1 gene Taurus_UMD|evm.model.AC_000175.1.915 P49771 FLT3L_HUMAN 78.771 0.607509 1.24681 FLT3LG - Fms-related tyrosine kinase 3 ligand precursor - Homo sapiens (Human) - FLT3LG gene Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. Taurus_UMD|evm.model.AC_000175.1.916 Q3SZ90 RL13A_BOVIN 100.000 0.990196 1.00493 RPL13A - 60S ribosomal protein L13a - Bos taurus (Bovine) - RPL13A gene Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity). Taurus_UMD|evm.model.AC_000175.1.917 P62282 RS11_RAT 100.000 0.987421 1.00633 Rps11 - 40S ribosomal protein S11 - Rattus norvegicus (Rat) - Rps11 gene cytosolic small ribosomal subunit, membrane, structural constituent of ribosome, osteoblast differentiation Taurus_UMD|evm.model.AC_000175.1.918 Q2KN22 FCGRN_CAMDR 83.708 0.994366 1 FCGRT - IgG receptor FcRn large subunit p51 precursor - Camelus dromedarius (Dromedary) - FCGRT gene Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB. Taurus_UMD|evm.model.AC_000175.1.919 Q2KJ39 RCN3_BOVIN 100.000 0.99177 0.740854 RCN3 - Reticulocalbin-3 precursor - Bos taurus (Bovine) - RCN3 gene Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (By similarity). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (By similarity). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (By similarity). Taurus_UMD|evm.model.AC_000175.1.920 Q3SWY5 NOSIP_BOVIN 100.000 0.993399 1.00331 NOSIP - Nitric oxide synthase-interacting protein - Bos taurus (Bovine) - NOSIP gene E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity). Taurus_UMD|evm.model.AC_000175.1.921 Q9ULL5 PRR12_HUMAN 96.965 0.6329 1.09578 PRR12 - Proline-rich protein 12 - Homo sapiens (Human) - PRR12 gene Taurus_UMD|evm.model.AC_000175.1.922 P10301 RRAS_HUMAN 96.789 0.990868 1.00459 RRAS - Ras-related protein R-Ras precursor - Homo sapiens (Human) - RRAS gene Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267). Taurus_UMD|evm.model.AC_000175.1.923 Q9H7N4 SFR19_HUMAN 93.684 0.507347 0.985518 SCAF1 - Splicing factor, arginine/serine-rich 19 - Homo sapiens (Human) - SCAF1 gene May function in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000175.1.924 Q4JF28 IRF3_BOVIN 100.000 0.995215 1.0024 IRF3 - Interferon regulatory factor 3 - Bos taurus (Bovine) - IRF3 gene Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. Taurus_UMD|evm.model.AC_000175.1.925 Q9HB09 B2L12_HUMAN 89.683 0.992095 0.757485 BCL2L12 - Bcl-2-like protein 12 - Homo sapiens (Human) - BCL2L12 gene membrane, nucleus, inhibition of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of transcription by RNA polymerase II, regulation of extrinsic apoptotic signaling pathway Taurus_UMD|evm.model.AC_000175.1.926 Q99873 ANM1_HUMAN 100.000 0.994624 1.0027 PRMT1 - Protein arginine N-methyltransferase 1 - Homo sapiens (Human) - PRMT1 gene Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:10749851, PubMed:16879614, PubMed:26876602). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Taurus_UMD|evm.model.AC_000175.1.927 A5LHG2 ADM5_PIG 79.048 0.916667 1 ADM5 - ADM5 precursor - Sus scrofa (Pig) - ADM5 gene Seems to have a peripheral vasodepressor effect and a central vasopressor effect. Taurus_UMD|evm.model.AC_000175.1.928 Q8TCG5 CPT1C_HUMAN 89.872 0.996154 0.971357 CPT1C - Carnitine O-palmitoyltransferase 1, brain isoform - Homo sapiens (Human) - CPT1C gene May play a role in lipid metabolic process. Taurus_UMD|evm.model.AC_000175.1.929 Q7TP54 RIPR2_RAT 50.962 0.926316 0.0725191 Ripor2 - Rho family-interacting cell polarization regulator 2 - Rattus norvegicus (Rat) - Ripor2 gene Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (By similarity). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (By similarity). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function. Required for normal hearing (By similarity). Taurus_UMD|evm.model.AC_000175.1.930 P60531 TSKS_RAT 90.102 0.99654 0.988034 Tsks - Testis-specific serine kinase substrate - Rattus norvegicus (Rat) - Tsks gene May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development. Taurus_UMD|evm.model.AC_000175.1.931 O95782 AP2A1_HUMAN 94.070 0.997932 0.989765 AP2A1 - AP-2 complex subunit alpha-1 - Homo sapiens (Human) - AP2A1 gene Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). Taurus_UMD|evm.model.AC_000175.1.932 Q9BT04 FUZZY_HUMAN 89.976 0.995238 1.00478 FUZ - Protein fuzzy homolog - Homo sapiens (Human) - FUZ gene Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity). Taurus_UMD|evm.model.AC_000175.1.933 A2VE44 MED25_BOVIN 100.000 0.750973 1.03351 MED25 - Mediator of RNA polymerase II transcription subunit 25 - Bos taurus (Bovine) - MED25 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription (By similarity). Taurus_UMD|evm.model.AC_000175.1.934 A4IFC9 PTOV1_BOVIN 100.000 0.995192 1.00241 PTOV1 - Prostate tumor-overexpressed gene 1 protein homolog - Bos taurus (Bovine) - PTOV1 gene May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000175.1.936 Q96T60 PNKP_HUMAN 85.249 0.996176 1.00384 PNKP - Bifunctional polynucleotide phosphatase/kinase - Homo sapiens (Human) - PNKP gene Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. Taurus_UMD|evm.model.AC_000175.1.938 Q96B36 AKTS1_HUMAN 94.922 0.920578 1.08203 AKT1S1 - Proline-rich AKT1 substrate 1 - Homo sapiens (Human) - AKT1S1 gene Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection. Taurus_UMD|evm.model.AC_000175.1.939 Q9HA65 TBC17_HUMAN 92.025 0.996937 1.00772 TBC1D17 - TBC1 domain family member 17 - Homo sapiens (Human) - TBC1D17 gene Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known. Taurus_UMD|evm.model.AC_000175.1.940 O09046 OXLA_MOUSE 73.084 0.90971 0.931746 Il4i1 - L-amino-acid oxidase precursor - Mus musculus (Mouse) - Il4i1 gene Secreted L-amino-acid oxidase that acts as a key immunoregulator (PubMed:32818467). Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively (PubMed:15383589). Also has weak L-arginine oxidase activity (By similarity). Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR (PubMed:21469114, PubMed:28405502, PubMed:32818467). IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer (By similarity). AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Also has an immunoregulatory function in some immune cell, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4(+) T-cells into FOXP3(+) regulatory T-cells (Treg) and regulates the development and function of B-cells (PubMed:25778793, PubMed:29288206). Also regulates M2 macrophage polarization by inhibiting T-cell activation (PubMed:26599209). Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4(+) and H2O2 (By similarity). Taurus_UMD|evm.model.AC_000175.1.941 P37198 NUP62_HUMAN 78.707 0.996161 0.998084 NUP62 - Nuclear pore glycoprotein p62 - Homo sapiens (Human) - NUP62 gene Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). Taurus_UMD|evm.model.AC_000175.1.942 O70191 ATF5_MOUSE 84.672 0.988889 0.954064 Atf5 - Cyclic AMP-dependent transcription factor ATF-5 - Mus musculus (Mouse) - Atf5 gene Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (By similarity). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate. Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (PubMed:22095825). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (PubMed:23090999). May be involved in osteogenic differentiation. Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (By similarity). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity) (PubMed:12130540). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver. In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase. May act as a negative regulator of IL1B transduction pathway in liver. Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members. Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation. Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (By similarity). Taurus_UMD|evm.model.AC_000175.1.943 Q96RL6 SIG11_HUMAN 58.122 0.687612 0.797994 SIGLEC11 - Sialic acid-binding Ig-like lectin 11 precursor - Homo sapiens (Human) - SIGLEC11 gene Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Taurus_UMD|evm.model.AC_000175.1.944 Q2YDN8 VRK3_BOVIN 100.000 0.995575 1.00222 VRK3 - Inactive serine/threonine-protein kinase VRK3 - Bos taurus (Bovine) - VRK3 gene Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus. Taurus_UMD|evm.model.AC_000175.1.945 Q8WTR7 ZN473_HUMAN 54.762 0.821782 0.115959 ZNF473 - Zinc finger protein 473 - Homo sapiens (Human) - ZNF473 gene Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases. Taurus_UMD|evm.model.AC_000175.1.946 Q6UXV1 IZUM2_HUMAN 71.429 0.90991 1.00452 IZUMO2 - Izumo sperm-egg fusion protein 2 precursor - Homo sapiens (Human) - IZUMO2 gene Taurus_UMD|evm.model.AC_000175.1.947 Q7Z406 MYH14_HUMAN 95.020 0.9793 1.01704 MYH14 - Myosin-14 - Homo sapiens (Human) - MYH14 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Taurus_UMD|evm.model.AC_000175.1.948 Q14003 KCNC3_HUMAN 98.507 0.675084 0.784676 KCNC3 - Potassium voltage-gated channel subfamily C member 3 - Homo sapiens (Human) - KCNC3 gene Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:26997484, PubMed:22289912, PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity). Required for normal motor function (PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484). Taurus_UMD|evm.model.AC_000175.1.949 O96009 NAPSA_HUMAN 80.206 0.948655 0.97381 NAPSA - Napsin-A precursor - Homo sapiens (Human) - NAPSA gene May be involved in processing of pneumocyte surfactant precursors. Taurus_UMD|evm.model.AC_000175.1.950 O70126 AURKB_MOUSE 73.394 0.64557 0.915942 Aurkb - Aurora kinase B - Mus musculus (Mouse) - Aurkb gene Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes. Taurus_UMD|evm.model.AC_000175.1.951 Q5BIS6 NR1H2_BOVIN 100.000 0.995614 1.0022 NR1H2 - Oxysterols receptor LXR-beta - Bos taurus (Bovine) - NR1H2 gene Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (By similarity). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity). Taurus_UMD|evm.model.AC_000175.1.952 P28339 DPOD1_BOVIN 95.325 0.986542 0.873418 POLD1 - DNA polymerase delta catalytic subunit - Bos taurus (Bovine) - POLD1 gene As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine, 8oxoG or abasic sites. Taurus_UMD|evm.model.AC_000175.1.953 Q01892 SPIB_HUMAN 87.405 0.992366 1 SPIB - Transcription factor Spi-B - Homo sapiens (Human) - SPIB gene Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. Taurus_UMD|evm.model.AC_000175.1.954 P28339 DPOD1_BOVIN 100.000 0.954545 0.079566 POLD1 - DNA polymerase delta catalytic subunit - Bos taurus (Bovine) - POLD1 gene As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine, 8oxoG or abasic sites. Taurus_UMD|evm.model.AC_000175.1.955 Q14324 MYPC2_HUMAN 85.395 0.982051 1.02542 MYBPC2 - Myosin-binding protein C, fast-type - Homo sapiens (Human) - MYBPC2 gene Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Taurus_UMD|evm.model.AC_000175.1.956 Q32L49 F71E1_BOVIN 99.535 0.990741 1.00465 FAM71E1 - Protein FAM71E1 - Bos taurus (Bovine) - FAM71E1 gene Taurus_UMD|evm.model.AC_000175.1.957 A1A4M2 EMC10_BOVIN 100.000 0.992395 1.00382 EMC10 - ER membrane protein complex subunit 10 precursor - Bos taurus (Bovine) - EMC10 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways. Taurus_UMD|evm.model.AC_000175.1.958 Q8TAC2 JOS2_HUMAN 96.277 0.989418 1.00532 JOSD2 - Josephin-2 - Homo sapiens (Human) - JOSD2 gene Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme. Taurus_UMD|evm.model.AC_000175.1.959 A6ND91 ASPD_HUMAN 86.477 0.754717 1.31095 ASPDH - Putative L-aspartate dehydrogenase - Homo sapiens (Human) - ASPDH gene Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. Taurus_UMD|evm.model.AC_000175.1.960 Q9NT99 LRC4B_HUMAN 97.475 0.997191 0.998597 LRRC4B - Leucine-rich repeat-containing protein 4B precursor - Homo sapiens (Human) - LRRC4B gene Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity). Taurus_UMD|evm.model.AC_000175.1.961 Q9BQG1 SYT3_HUMAN 97.800 0.996622 1.00339 SYT3 - Synaptotagmin-3 - Homo sapiens (Human) - SYT3 gene Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Taurus_UMD|evm.model.AC_000175.1.962 C9J6K1 CS081_HUMAN 84.772 0.984925 1.00505 C19orf81 - Putative uncharacterized protein C19orf81 - Homo sapiens (Human) - C19orf81 gene Taurus_UMD|evm.model.AC_000175.1.963 Q9Y566 SHAN1_HUMAN 95.033 0.506595 0.947247 SHANK1 - SH3 and multiple ankyrin repeat domains protein 1 - Homo sapiens (Human) - SHANK1 gene Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Taurus_UMD|evm.model.AC_000175.1.964 Q9Y240 CLC11_HUMAN 87.037 0.993846 1.00619 CLEC11A - C-type lectin domain family 11 member A precursor - Homo sapiens (Human) - CLEC11A gene Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts (PubMed:27976999). Important for repair and maintenance of adult bone (By similarity). Taurus_UMD|evm.model.AC_000175.1.965 O75388 GPR32_HUMAN 47.256 0.9375 0.853933 GPR32 - Probable G-protein coupled receptor 32 - Homo sapiens (Human) - GPR32 gene Orphan receptor. Taurus_UMD|evm.model.AC_000175.1.967 Q9BZG2 PPAT_HUMAN 86.111 0.99537 1.01408 ACP4 - Testicular acid phosphatase precursor - Homo sapiens (Human) - ACP4 gene May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage (PubMed:15219672). May play a role in odontogenesis (PubMed:27843125). Taurus_UMD|evm.model.AC_000175.1.968 P70213 FV1_MOUSE 30.220 0.646209 0.603486 Fv1 - Friend virus susceptibility protein 1 - Mus musculus (Mouse) - Fv1 gene Retroviral restriction factor that prevents infection by gammaretroviruses. Acts by interacting with the capsid protein ca after entry of the virus into the cell. This interaction presumably disrupt the capsid thereby inactivating the viral genome, making it unable to enter host nucleus and integrate into host genome. Taurus_UMD|evm.model.AC_000175.1.970 P00752 KLK_PIG 73.361 0.528509 1.85366 Glandular kallikrein precursor - Sus scrofa (Pig) Taurus_UMD|evm.model.AC_000175.1.971 Q9Y5K2 KLK4_HUMAN 78.571 0.918605 1.01575 KLK4 - Kallikrein-4 precursor - Homo sapiens (Human) - KLK4 gene Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity). Taurus_UMD|evm.model.AC_000175.1.972 Q92876 KLK6_HUMAN 81.545 0.435272 2.18443 KLK6 - Kallikrein-6 precursor - Homo sapiens (Human) - KLK6 gene Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. Taurus_UMD|evm.model.AC_000175.1.973 P49862 KLK7_HUMAN 77.974 0.888889 0.996047 KLK7 - Kallikrein-7 precursor - Homo sapiens (Human) - KLK7 gene May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. Taurus_UMD|evm.model.AC_000175.1.974 O60259 KLK8_HUMAN 71.923 0.992308 1 KLK8 - Kallikrein-8 precursor - Homo sapiens (Human) - KLK8 gene Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. Taurus_UMD|evm.model.AC_000175.1.975 Q9UKQ9 KLK9_HUMAN 88.936 0.928571 1.008 KLK9 - Kallikrein-9 precursor - Homo sapiens (Human) - KLK9 gene secretory granule, serine-type endopeptidase activity Taurus_UMD|evm.model.AC_000175.1.976 O43240 KLK10_HUMAN 82.500 0.992883 1.01812 KLK10 - Kallikrein-10 precursor - Homo sapiens (Human) - KLK10 gene Has a tumor-suppressor role for NES1 in breast and prostate cancer. Taurus_UMD|evm.model.AC_000175.1.977 Q9UBX7 KLK11_HUMAN 82.773 0.944223 0.890071 KLK11 - Kallikrein-11 precursor - Homo sapiens (Human) - KLK11 gene Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. Taurus_UMD|evm.model.AC_000175.1.978 Q9UKR0 KLK12_HUMAN 78.629 0.991968 1.00403 KLK12 - Kallikrein-12 precursor - Homo sapiens (Human) - KLK12 gene extracellular region, extracellular space, secretory granule, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity, cornification, proteolysis Taurus_UMD|evm.model.AC_000175.1.979 Q9UKR3 KLK13_HUMAN 80.576 0.992832 1.00722 KLK13 - Kallikrein-13 precursor - Homo sapiens (Human) - KLK13 gene cytoplasm, extracellular region, secretory granule, hydrolase activity, serine-type endopeptidase activity, cornification, proteolysis Taurus_UMD|evm.model.AC_000175.1.980 Q9P0G3 KLK14_HUMAN 77.291 0.988095 0.94382 KLK14 - Kallikrein-14 precursor - Homo sapiens (Human) - KLK14 gene Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. Taurus_UMD|evm.model.AC_000175.1.981 Q0VC66 CTU1_BOVIN 100.000 0.994253 1.00288 CTU1 - Cytoplasmic tRNA 2-thiolation protein 1 - Bos taurus (Bovine) - CTU1 gene Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Taurus_UMD|evm.model.AC_000175.1.982 A8MTB9 CEA18_HUMAN 57.333 0.510274 1.52083 CEACAM18 - Carcinoembryonic antigen-related cell adhesion molecule 18 precursor - Homo sapiens (Human) - CEACAM18 gene Taurus_UMD|evm.model.AC_000175.1.983 P20138 CD33_HUMAN 66.667 0.944444 0.642857 CD33 - Myeloid cell surface antigen CD33 precursor - Homo sapiens (Human) - CD33 gene Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323). Taurus_UMD|evm.model.AC_000175.1.984 O43699 SIGL6_HUMAN 57.965 0.607629 0.810155 SIGLEC6 - Sialic acid-binding Ig-like lectin 6 precursor - Homo sapiens (Human) - SIGLEC6 gene Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Taurus_UMD|evm.model.AC_000175.1.989 Q8N7X8 SIGL1_HUMAN 57.988 0.325444 2.5736 SIGLECL1 - SIGLEC family-like protein 1 - Homo sapiens (Human) - SIGLECL1 gene plasma membrane, sialic acid binding, cell adhesion Taurus_UMD|evm.model.AC_000175.1.990 Q8HW98 IGLO5_MOUSE 97.917 0.994065 1.00298 Iglon5 - IgLON family member 5 precursor - Mus musculus (Mouse) - Iglon5 gene Taurus_UMD|evm.model.AC_000175.1.991 Q86VR7 VS10L_HUMAN 72.759 0.977011 1.00346 VSIG10L - V-set and immunoglobulin domain-containing protein 10-like precursor - Homo sapiens (Human) - VSIG10L gene nucleoplasm Taurus_UMD|evm.model.AC_000175.1.992 Q2TBV3 ETFB_BOVIN 100.000 0.992188 1.00392 ETFB - Electron transfer flavoprotein subunit beta - Bos taurus (Bovine) - ETFB gene Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role. Taurus_UMD|evm.model.AC_000175.1.993 Q2KJ11 NKG7_BOVIN 100.000 0.452012 1.95758 NKG7 - Protein NKG7 - Bos taurus (Bovine) - NKG7 gene plasma membrane Taurus_UMD|evm.model.AC_000175.1.994 P20274 LMIP_BOVIN 100.000 0.988506 1.00578 LIM2 - Lens fiber membrane intrinsic protein - Bos taurus (Bovine) - LIM2 gene Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. Taurus_UMD|evm.model.AC_000175.1.995 Q96LC7 SIG10_HUMAN 62.500 0.977175 1.00574 SIGLEC10 - Sialic acid-binding Ig-like lectin 10 precursor - Homo sapiens (Human) - SIGLEC10 gene Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity). Taurus_UMD|evm.model.AC_000175.1.996 Q9NYZ4 SIGL8_HUMAN 67.826 0.250374 2.68136 SIGLEC8 - Sialic acid-binding Ig-like lectin 8 precursor - Homo sapiens (Human) - SIGLEC8 gene Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (PubMed:10856141, PubMed:10625619). Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619). Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658). Taurus_UMD|evm.model.AC_000175.1.997 Q9Y473 ZN175_HUMAN 78.348 0.911573 1.08158 ZNF175 - Zinc finger protein 175 - Homo sapiens (Human) - ZNF175 gene Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity. Taurus_UMD|evm.model.AC_000175.1.998 Q5NVN3 B4GT3_PONAB 43.396 0.846774 0.315522 B4GALT3 - Beta-1,4-galactosyltransferase 3 - Pongo abelii (Sumatran orangutan) - B4GALT3 gene Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Taurus_UMD|evm.model.AC_000175.1.999 Q0VC66 CTU1_BOVIN 99.135 0.994253 1.00288 CTU1 - Cytoplasmic tRNA 2-thiolation protein 1 - Bos taurus (Bovine) - CTU1 gene Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Taurus_UMD|evm.model.AC_000175.1.1000 O15389 SIGL5_HUMAN 62.340 0.978221 1 SIGLEC5 - Sialic acid-binding Ig-like lectin 5 precursor - Homo sapiens (Human) - SIGLEC5 gene Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Taurus_UMD|evm.model.AC_000175.1.1001 Q08ET2 SIG14_HUMAN 64.362 0.963255 0.962121 SIGLEC14 - Sialic acid-binding Ig-like lectin 14 precursor - Homo sapiens (Human) - SIGLEC14 gene Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors. Taurus_UMD|evm.model.AC_000175.1.1002 Q08ET2 SIG14_HUMAN 61.480 0.9675 1.0101 SIGLEC14 - Sialic acid-binding Ig-like lectin 14 precursor - Homo sapiens (Human) - SIGLEC14 gene Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors. Taurus_UMD|evm.model.AC_000175.1.1003 Q08ET2 SIG14_HUMAN 75.926 0.23301 0.520202 SIGLEC14 - Sialic acid-binding Ig-like lectin 14 precursor - Homo sapiens (Human) - SIGLEC14 gene Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors. Taurus_UMD|evm.model.AC_000175.1.1004 Q08ET2 SIG14_HUMAN 61.214 0.966146 0.969697 SIGLEC14 - Sialic acid-binding Ig-like lectin 14 precursor - Homo sapiens (Human) - SIGLEC14 gene Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors. Taurus_UMD|evm.model.AC_000175.1.1005 Q61647 HYAS1_MOUSE 100.000 0.292063 0.540309 Has1 - Hyaluronan synthase 1 - Mus musculus (Mouse) - Has1 gene Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate. Taurus_UMD|evm.model.AC_000175.1.1006 Q61647 HYAS1_MOUSE 94.678 0.969945 0.627787 Has1 - Hyaluronan synthase 1 - Mus musculus (Mouse) - Has1 gene Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate. Taurus_UMD|evm.model.AC_000175.1.1007 P51523 ZNF84_HUMAN 64.413 0.310078 1.22358 ZNF84 - Zinc finger protein 84 - Homo sapiens (Human) - ZNF84 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1008 Q6PF04 ZN613_HUMAN 75.203 0.957944 1.04052 ZNF613 - Zinc finger protein 613 - Homo sapiens (Human) - ZNF613 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1009 O94892 ZN432_HUMAN 77.545 0.99256 1.03067 ZNF432 - Zinc finger protein 432 - Homo sapiens (Human) - ZNF432 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1010 Q95K49 ZN614_MACFA 74.740 0.984615 1.00515 ZNF614 - Zinc finger protein 614 - Macaca fascicularis (Crab-eating macaque) - ZNF614 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1011 P38983 RSSA_RAT 96.522 0.102334 3.77627 Rpsa - 40S ribosomal protein SA - Rattus norvegicus (Rat) - Rpsa gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. Taurus_UMD|evm.model.AC_000175.1.1012 Q32PI5 2AAA_BOVIN 99.830 0.99661 1.0017 PPP2R1A - Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform - Bos taurus (Bovine) - PPP2R1A gene The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. Taurus_UMD|evm.model.AC_000175.1.1018 Q96SE7 ZN347_HUMAN 58.352 0.483243 1.1025 ZNF347 - Zinc finger protein 347 - Homo sapiens (Human) - ZNF347 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1019 Q9H7R5 ZN665_HUMAN 66.667 0.119342 0.358407 ZNF665 - Zinc finger protein 665 - Homo sapiens (Human) - ZNF665 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1020 P10575 GLRX1_BOVIN 78.571 0.982301 1.06604 GLRX - Glutaredoxin-1 - Bos taurus (Bovine) - GLRX gene Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Taurus_UMD|evm.model.AC_000175.1.1021 Q9HCG1 ZN160_HUMAN 60.394 0.545187 1.2445 ZNF160 - Zinc finger protein 160 - Homo sapiens (Human) - ZNF160 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1022 Q86XU0 ZN677_HUMAN 68.889 0.232044 0.309932 ZNF677 - Zinc finger protein 677 - Homo sapiens (Human) - ZNF677 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1023 B2MVY4 CDK4_SHEEP 93.443 0.98913 0.607261 Cyclin-dependent kinase 4 - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000175.1.1024 B2MVY4 CDK4_SHEEP 92.453 0.452174 0.379538 Cyclin-dependent kinase 4 - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000175.1.1025 Q8IW36 ZN695_HUMAN 57.692 0.548387 0.180583 ZNF695 - Zinc finger protein 695 - Homo sapiens (Human) - ZNF695 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1026 P10575 GLRX1_BOVIN 85.714 0.978261 0.867925 GLRX - Glutaredoxin-1 - Bos taurus (Bovine) - GLRX gene Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Taurus_UMD|evm.model.AC_000175.1.1027 P56383 AT5G2_MOUSE 75.862 0.934426 0.417808 Atp5mc2 - ATP synthase F(0) complex subunit C2, mitochondrial precursor - Mus musculus (Mouse) - Atp5mc2 gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element. Taurus_UMD|evm.model.AC_000175.1.1028 Q96SE7 ZN347_HUMAN 62.363 0.566719 0.759237 ZNF347 - Zinc finger protein 347 - Homo sapiens (Human) - ZNF347 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1029 Q8N5G0 SIM20_HUMAN 96.667 0.364198 2.41791 SMIM20 - Small integral membrane protein 20 - Homo sapiens (Human) - SMIM20 gene Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (PubMed:26321642). Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C (PubMed:26321642). Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover (PubMed:26321642). Taurus_UMD|evm.model.AC_000175.1.1030 Q6ZN19 ZN841_HUMAN 50.418 0.350993 1.68193 ZNF841 - Zinc finger protein 841 - Homo sapiens (Human) - ZNF841 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1031 Q5VIY5 ZN468_HUMAN 77.500 0.221591 0.337165 ZNF468 - Zinc finger protein 468 - Homo sapiens (Human) - ZNF468 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1032 P61161 ARP2_MOUSE 94.670 0.994937 1.00254 Actr2 - Actin-related protein 2 - Mus musculus (Mouse) - Actr2 gene ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Taurus_UMD|evm.model.AC_000175.1.1033 Q05481 ZNF91_HUMAN 55.882 0.107875 0.778338 ZNF91 - Zinc finger protein 91 - Homo sapiens (Human) - ZNF91 gene Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidence is required to confirm this result in vivo (PubMed:11470777). Taurus_UMD|evm.model.AC_000175.1.1034 Q9H7R5 ZN665_HUMAN 47.531 0.558304 0.417404 ZNF665 - Zinc finger protein 665 - Homo sapiens (Human) - ZNF665 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1036 Q96SE7 ZN347_HUMAN 60.143 0.381519 1.30274 ZNF347 - Zinc finger protein 347 - Homo sapiens (Human) - ZNF347 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1037 A6NN14 ZN729_HUMAN 58.406 0.752735 0.730032 ZNF729 - Zinc finger protein 729 - Homo sapiens (Human) - ZNF729 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1038 Q09FC8 ZN415_HUMAN 40.230 0.66129 0.205638 ZNF415 - Zinc finger protein 415 - Homo sapiens (Human) - ZNF415 gene Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53. Taurus_UMD|evm.model.AC_000175.1.1039 Q86XU0 ZN677_HUMAN 65.217 0.362903 0.212329 ZNF677 - Zinc finger protein 677 - Homo sapiens (Human) - ZNF677 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1040 Q86XU0 ZN677_HUMAN 45.113 0.579439 0.366438 ZNF677 - Zinc finger protein 677 - Homo sapiens (Human) - ZNF677 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1041 Q9H7R5 ZN665_HUMAN 55.263 0.603261 0.271386 ZNF665 - Zinc finger protein 665 - Homo sapiens (Human) - ZNF665 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1042 Q96SE7 ZN347_HUMAN 59.338 0.687908 0.72944 ZNF347 - Zinc finger protein 347 - Homo sapiens (Human) - ZNF347 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1044 Q96IR2 ZN845_HUMAN 78.723 0.178988 0.264948 ZNF845 - Zinc finger protein 845 - Homo sapiens (Human) - ZNF845 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1045 Q9H7R5 ZN665_HUMAN 60.435 0.627235 1.07227 ZNF665 - Zinc finger protein 665 - Homo sapiens (Human) - ZNF665 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1046 Q96SE7 ZN347_HUMAN 63.158 0.626459 0.612634 ZNF347 - Zinc finger protein 347 - Homo sapiens (Human) - ZNF347 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1047 A6NGY1 FRG2C_HUMAN 43.169 0.873171 0.72695 FRG2C - Protein FRG2-like-2 - Homo sapiens (Human) - FRG2C gene Taurus_UMD|evm.model.AC_000175.1.1049 Q7Z2F6 ZN720_HUMAN 64.865 0.192105 3.01587 ZNF720 - Putative protein ZNF720 - Homo sapiens (Human) - ZNF720 gene Taurus_UMD|evm.model.AC_000175.1.1050 P63174 RL38_RAT 78.571 0.971831 1.01429 Rpl38 - 60S ribosomal protein L38 - Rattus norvegicus (Rat) - Rpl38 gene cytosolic large ribosomal subunit, eukaryotic 80S initiation complex, polysomal ribosome, postsynaptic density, synapse, structural constituent of ribosome, 90S preribosome assembly, axial mesoderm development, cytoplasmic translation, middle ear morphogenesis Taurus_UMD|evm.model.AC_000175.1.1051 Q8WV37 ZN480_HUMAN 43.651 0.440141 0.530841 ZNF480 - Zinc finger protein 480 - Homo sapiens (Human) - ZNF480 gene Involved in transcriptional regulation as an activator. Taurus_UMD|evm.model.AC_000175.1.1052 Q96IR2 ZN845_HUMAN 76.596 0.567901 0.0835052 ZNF845 - Zinc finger protein 845 - Homo sapiens (Human) - ZNF845 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1053 Q8TAQ5 ZN420_HUMAN 71.111 0.0443102 1.44331 ZNF420 - Zinc finger protein 420 - Homo sapiens (Human) - ZNF420 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1054 Q7Z2F6 ZN720_HUMAN 55.932 0.423358 2.1746 ZNF720 - Putative protein ZNF720 - Homo sapiens (Human) - ZNF720 gene Taurus_UMD|evm.model.AC_000175.1.1055 P62275 RS29_RAT 92.857 0.964912 1.01786 Rps29 - 40S ribosomal protein S29 - Rattus norvegicus (Rat) - Rps29 gene cytosolic small ribosomal subunit, polysomal ribosome, structural constituent of ribosome, zinc ion binding, cytoplasmic translation, positive regulation of apoptotic process Taurus_UMD|evm.model.AC_000175.1.1056 P30050 RL12_HUMAN 76.970 0.985401 0.830303 RPL12 - 60S ribosomal protein L12 - Homo sapiens (Human) - RPL12 gene Binds directly to 26S ribosomal RNA. Taurus_UMD|evm.model.AC_000175.1.1057 A2VDQ7 ZN420_BOVIN 68.182 0.0361041 1.73362 ZNF420 - Zinc finger protein 420 - Bos taurus (Bovine) - ZNF420 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1058 Q8WY07 CTR3_HUMAN 70.195 0.569963 1.73183 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1059 Q8WY07 CTR3_HUMAN 70.588 0.36875 0.516963 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1060 P59046 NAL12_HUMAN 81.250 0.307971 0.780396 NLRP12 - NACHT, LRR and PYD domains-containing protein 12 - Homo sapiens (Human) - NLRP12 gene Plays an essential role as an potent mitigator of inflammation (PubMed:30559449). Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:15489334, PubMed:17947705). Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449). In turn, promotes bacterial tolerance (PubMed:30559449). Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation (PubMed:30902577). Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity). Taurus_UMD|evm.model.AC_000175.1.1062 Q8WY07 CTR3_HUMAN 59.381 0.569055 1.55574 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1064 Q8WY07 CTR3_HUMAN 55.814 0.985246 0.98546 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1065 Q8WY07 CTR3_HUMAN 51.573 0.981917 0.893376 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1066 P70423 CTR3_MOUSE 55.738 0.378257 1.80097 Slc7a3 - Cationic amino acid transporter 3 - Mus musculus (Mouse) - Slc7a3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1067 Q8WY07 CTR3_HUMAN 66.076 0.287381 2.21486 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1068 O08812 CTR3_RAT 52.273 0.364407 0.19063 Slc7a3 - Cationic amino acid transporter 3 - Rattus norvegicus (Rat) - Slc7a3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1069 Q8WY07 CTR3_HUMAN 63.768 0.192725 4.61874 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1070 Q8WY07 CTR3_HUMAN 57.861 0.980614 1 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1071 Q8WY07 CTR3_HUMAN 58.347 0.990164 0.98546 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1072 O08812 CTR3_RAT 56.886 0.887701 0.3021 Slc7a3 - Cationic amino acid transporter 3 - Rattus norvegicus (Rat) - Slc7a3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1073 O08812 CTR3_RAT 59.740 0.766667 1.2601 Slc7a3 - Cationic amino acid transporter 3 - Rattus norvegicus (Rat) - Slc7a3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1074 Q8WY07 CTR3_HUMAN 65.049 0.980892 1.01454 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1075 Q8WY07 CTR3_HUMAN 64.706 0.128244 1.05816 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1076 Q8WY07 CTR3_HUMAN 62.681 0.750341 1.18417 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1077 Q8WY07 CTR3_HUMAN 58.710 0.609467 1.63813 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1078 Q8WY07 CTR3_HUMAN 59.355 0.980952 1.01777 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1079 Q8WY07 CTR3_HUMAN 60.479 0.402913 0.66559 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1080 Q8WY07 CTR3_HUMAN 62.249 0.442068 1.8126 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1081 Q8WY07 CTR3_HUMAN 65.327 0.991667 0.969305 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1082 P58352 GTR3_BOVIN 85.590 0.227772 2.02632 SLC2A3 - Solute carrier family 2, facilitated glucose transporter member 3 - Bos taurus (Bovine) - SLC2A3 gene Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Taurus_UMD|evm.model.AC_000175.1.1083 P13619 AT5F1_BOVIN 95.122 0.755556 1.05469 ATP5PB - ATP synthase F(0) complex subunit B1, mitochondrial precursor - Bos taurus (Bovine) - ATP5PB gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Taurus_UMD|evm.model.AC_000175.1.1084 P47843 GTR3_SHEEP 86.667 0.341655 2.83806 SLC2A3 - Solute carrier family 2, facilitated glucose transporter member 3 - Ovis aries (Sheep) - SLC2A3 gene Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Taurus_UMD|evm.model.AC_000175.1.1085 Q8WY07 CTR3_HUMAN 52.922 0.973638 0.919225 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000175.1.1086 Q96S97 MYADM_HUMAN 89.441 0.649798 1.53416 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000175.1.1088 P05128 KPCG_BOVIN 100.000 0.975645 1.02346 PRKCG - Protein kinase C gamma type - Bos taurus (Bovine) - PRKCG gene Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock. Taurus_UMD|evm.model.AC_000175.1.1089 P62957 CCG7_RAT 100.000 0.992754 1.00364 Cacng7 - Voltage-dependent calcium channel gamma-7 subunit - Rattus norvegicus (Rat) - Cacng7 gene Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:18817736, PubMed:19234459). Shows specificity only for GRIA1 and GRIA2 (By similarity). Taurus_UMD|evm.model.AC_000175.1.1090 Q8WXS5 CCG8_HUMAN 97.203 0.44741 1.49882 CACNG8 - Voltage-dependent calcium channel gamma-8 subunit - Homo sapiens (Human) - CACNG8 gene Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Taurus_UMD|evm.model.AC_000175.1.1091 Q6UX27 VSTM1_HUMAN 55.856 0.764286 0.59322 VSTM1 - V-set and transmembrane domain-containing protein 1 precursor - Homo sapiens (Human) - VSTM1 gene Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17). Taurus_UMD|evm.model.AC_000175.1.1093 Q288C4 NLRP9_BOVIN 99.598 0.997994 1.001 NLRP9 - NACHT, LRR and PYD domains-containing protein 9 - Bos taurus (Bovine) - NLRP9 gene As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments. Taurus_UMD|evm.model.AC_000175.1.1095 D4ABM4 RFPLA_RAT 58.442 0.375 0.701754 Rfpl4a - Ret finger protein-like 4A - Rattus norvegicus (Rat) - Rfpl4a gene chromatin, cytoplasm, nucleoplasm, nucleus, ubiquitin-protein transferase activity, positive regulation of transcription, DNA-templated Taurus_UMD|evm.model.AC_000175.1.1096 Q5J3F6 V1R90_RAT 43.750 0.521008 0.383871 Vom1r90 - Vomeronasal type-1 receptor 90 - Rattus norvegicus (Rat) - Vom1r90 gene Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior. Taurus_UMD|evm.model.AC_000175.1.1097 Q9Y6I3 EPN1_HUMAN 93.750 0.996534 1.00174 EPN1 - Epsin-1 - Homo sapiens (Human) - EPN1 gene Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10557078, PubMed:10393179). Taurus_UMD|evm.model.AC_000175.1.1098 P26369 U2AF2_MOUSE 98.947 0.995763 0.993684 U2af2 - Splicing factor U2AF 65 kDa subunit - Mus musculus (Mouse) - U2af2 gene Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals. Taurus_UMD|evm.model.AC_000175.1.1099 Q1LZ89 CC106_BOVIN 100.000 0.992832 1.0036 CCDC106 - Coiled-coil domain-containing protein 106 - Bos taurus (Bovine) - CCDC106 gene Promotes the degradation of p53/TP53 protein and inhibits its transactivity. Taurus_UMD|evm.model.AC_000175.1.1100 Q9P0T4 ZN581_HUMAN 85.859 0.98995 1.01015 ZNF581 - Zinc finger protein 581 - Homo sapiens (Human) - ZNF581 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1101 Q9UK33 ZN580_HUMAN 94.872 0.895954 1.00581 ZNF580 - Zinc finger protein 580 - Homo sapiens (Human) - ZNF580 gene Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1104 Q8BI69 ZN784_MOUSE 82.292 0.907937 1.06061 Znf784 - Zinc finger protein 784 - Mus musculus (Mouse) - Znf784 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1105 P0CJ78 ZN865_HUMAN 86.236 0.998064 0.975449 ZNF865 - Zinc finger protein 865 - Homo sapiens (Human) - ZNF865 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1106 Q96C55 ZN524_HUMAN 85.542 0.924812 1.00758 ZNF524 - Zinc finger protein 524 - Homo sapiens (Human) - ZNF524 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1107 Q96SL8 FIZ1_HUMAN 84.490 0.907869 1.0504 FIZ1 - Flt3-interacting zinc finger protein 1 - Homo sapiens (Human) - FIZ1 gene May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity). Taurus_UMD|evm.model.AC_000175.1.1108 Q8NAF0 ZN579_HUMAN 83.397 0.919786 0.998221 ZNF579 - Zinc finger protein 579 - Homo sapiens (Human) - ZNF579 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1109 P0C5K0 SBK3_MOUSE 84.416 0.841096 1.01108 Sbk3 - Uncharacterized serine/threonine-protein kinase SBK3 - Mus musculus (Mouse) - Sbk3 gene protein serine/threonine kinase activity Taurus_UMD|evm.model.AC_000175.1.1110 P0C263 SBK2_HUMAN 77.364 0.90625 1.10345 SBK2 - Serine/threonine-protein kinase SBK2 - Homo sapiens (Human) - SBK2 gene MAP kinase kinase activity, activation of MAPK activity Taurus_UMD|evm.model.AC_000175.1.1112 A1L4H1 SRCRL_HUMAN 77.419 0.763354 0.940242 SSC5D - Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D precursor - Homo sapiens (Human) - SSC5D gene Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity). Taurus_UMD|evm.model.AC_000175.1.1113 Q3MHZ1 NAT14_BOVIN 100.000 0.990338 1.00485 NAT14 - N-acetyltransferase 14 - Bos taurus (Bovine) - NAT14 gene Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro (By similarity). Taurus_UMD|evm.model.AC_000175.1.1114 Q5EBL2 ZN628_HUMAN 84.087 0.99806 0.97356 ZNF628 - Zinc finger protein 628 - Homo sapiens (Human) - ZNF628 gene Transcriptional activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3'. Plays a role in spermiogenesis. Taurus_UMD|evm.model.AC_000175.1.1116 Q32KX0 ISOC2_BOVIN 99.510 0.990244 1.0049 ISOC2 - Isochorismatase domain-containing protein 2 - Bos taurus (Bovine) - ISOC2 gene cytoplasm Taurus_UMD|evm.model.AC_000175.1.1117 Q8C3Q5 SHSA7_MOUSE 89.343 0.97227 1.03405 Shisa7 - Protein shisa-7 precursor - Mus musculus (Mouse) - Shisa7 gene Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain (PubMed:31601770). Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain (PubMed:31601770). May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall (Probable). May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses (Probable). Taurus_UMD|evm.model.AC_000175.1.1119 Q1RML1 UBE2S_BOVIN 100.000 0.991071 1.00448 UBE2S - Ubiquitin-conjugating enzyme E2 S - Bos taurus (Bovine) - UBE2S gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. Taurus_UMD|evm.model.AC_000175.1.1120 Q3T0L7 RL28_BOVIN 100.000 0.819277 1.21168 RPL28 - 60S ribosomal protein L28 - Bos taurus (Bovine) - RPL28 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000175.1.1121 C9JI98 TM238_HUMAN 78.750 0.908046 0.494318 TMEM238 - Transmembrane protein 238 - Homo sapiens (Human) - TMEM238 gene Taurus_UMD|evm.model.AC_000175.1.1122 E1BJD3 TM190_BOVIN 100.000 0.98895 1.00556 TMEM190 - Transmembrane protein 190 precursor - Bos taurus (Bovine) - TMEM190 gene inner acrosomal membrane, hematopoietic progenitor cell differentiation Taurus_UMD|evm.model.AC_000175.1.1123 P20809 IL11_HUMAN 77.387 0.988304 0.859296 IL11 - Interleukin-11 precursor - Homo sapiens (Human) - IL11 gene Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168). Taurus_UMD|evm.model.AC_000175.1.1124 Q8N5Q1 F71E2_HUMAN 50.811 0.997658 0.926247 FAM71E2 - Protein FAM71E2 - Homo sapiens (Human) - FAM71E2 gene Taurus_UMD|evm.model.AC_000175.1.1125 Q6YFP9 CX6B2_BOVIN 100.000 0.977528 1.01136 COX6B2 - Cytochrome c oxidase subunit 6B2 - Bos taurus (Bovine) - COX6B2 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000175.1.1126 Q86Y97 KMT5C_HUMAN 85.345 0.991266 0.991342 KMT5C - Histone-lysine N-methyltransferase KMT5C - Homo sapiens (Human) - KMT5C gene Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). Taurus_UMD|evm.model.AC_000175.1.1128 A7MBB3 T150B_BOVIN 100.000 0.991525 1.00426 TMEM150B - Modulator of macroautophagy TMEM150B - Bos taurus (Bovine) - TMEM150B gene Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (By similarity). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (By similarity). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (By similarity). Taurus_UMD|evm.model.AC_000175.1.1129 Q8TDC3 BRSK1_HUMAN 98.805 0.926017 1.04242 BRSK1 - Serine/threonine-protein kinase BRSK1 - Homo sapiens (Human) - BRSK1 gene Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. Taurus_UMD|evm.model.AC_000175.1.1130 Q99P31 HPBP1_MOUSE 95.238 0.994413 1.0028 Hspbp1 - Hsp70-binding protein 1 - Mus musculus (Mouse) - Hspbp1 gene Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity). Taurus_UMD|evm.model.AC_000175.1.1131 Q9UPN7 PP6R1_HUMAN 79.228 0.985437 0.935301 PPP6R1 - Serine/threonine-protein phosphatase 6 regulatory subunit 1 - Homo sapiens (Human) - PPP6R1 gene Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Taurus_UMD|evm.model.AC_000175.1.1132 Q3T0W0 TM86B_BOVIN 100.000 0.991111 1.00446 TMEM86B - Lysoplasmalogenase - Bos taurus (Bovine) - TMEM86B gene Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties. Taurus_UMD|evm.model.AC_000175.1.1133 Q9HD43 PTPRH_HUMAN 65.934 0.948563 0.592825 PTPRH - Receptor-type tyrosine-protein phosphatase H precursor - Homo sapiens (Human) - PTPRH gene Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity). Taurus_UMD|evm.model.AC_000175.1.1134 O00445 SYT5_HUMAN 95.337 0.994832 1.00259 SYT5 - Synaptotagmin-5 - Homo sapiens (Human) - SYT5 gene May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity). Taurus_UMD|evm.model.AC_000175.1.1135 F1MLB4 DAAF3_BOVIN 100.000 0.800885 1.24632 DNAAF3 - Dynein axonemal assembly factor 3 - Bos taurus (Bovine) - DNAAF3 gene Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia (By similarity). Taurus_UMD|evm.model.AC_000175.1.1136 P08057 TNNI3_BOVIN 100.000 0.99061 1.00472 TNNI3 - Troponin I, cardiac muscle - Bos taurus (Bovine) - TNNI3 gene Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Taurus_UMD|evm.model.AC_000175.1.1137 Q8MKH6 TNNT1_BOVIN 100.000 0.992424 1.0038 TNNT1 - Troponin T, slow skeletal muscle - Bos taurus (Bovine) - TNNT1 gene Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Taurus_UMD|evm.model.AC_000175.1.1138 Q9BZL4 PP12C_HUMAN 87.923 0.854356 0.983376 PPP1R12C - Protein phosphatase 1 regulatory subunit 12C - Homo sapiens (Human) - PPP1R12C gene Regulates myosin phosphatase activity. Taurus_UMD|evm.model.AC_000175.1.1139 Q8TE68 ES8L1_HUMAN 72.377 0.99734 1.04011 EPS8L1 - Epidermal growth factor receptor kinase substrate 8-like protein 1 - Homo sapiens (Human) - EPS8L1 gene Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. Taurus_UMD|evm.model.AC_000175.1.1140 Q8NBN7 RDH13_HUMAN 85.373 0.994048 1.01511 RDH13 - Retinol dehydrogenase 13 - Homo sapiens (Human) - RDH13 gene Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency (PubMed:18039331). Has no activity toward steroids (PubMed:18039331). Taurus_UMD|evm.model.AC_000175.1.1141 Q14954 KI2S1_HUMAN 52.406 0.521008 1.17434 KIR2DS1 - Killer cell immunoglobulin-like receptor 2DS1 precursor - Homo sapiens (Human) - KIR2DS1 gene Receptor on natural killer (NK) cells for some HLA-C alleles such as w6. Does not inhibit the activity of NK cells. Taurus_UMD|evm.model.AC_000175.1.1142 P24071 FCAR_HUMAN 55.212 0.917563 0.972125 FCAR - Immunoglobulin alpha Fc receptor precursor - Homo sapiens (Human) - FCAR gene Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. Taurus_UMD|evm.model.AC_000175.1.1143 Q863H2 NCTR1_BOVIN 86.800 0.886029 0.883117 NCR1 - Natural cytotoxicity triggering receptor 1 precursor - Bos taurus (Bovine) - NCR1 gene Cytotoxicity activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Taurus_UMD|evm.model.AC_000175.1.1144 Q8WX94 NALP7_HUMAN 60.488 0.889011 0.928571 NLRP7 - NACHT, LRR and PYD domains-containing protein 7 - Homo sapiens (Human) - NLRP7 gene Inhibits CASP1/caspase-1-dependent IL1B secretion. Taurus_UMD|evm.model.AC_000175.1.1145 Q8MJZ2 LIRA6_PANTR 44.643 0.538835 0.428274 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Pan troglodytes (Chimpanzee) - LILRA6 gene May act as receptor for class I MHC antigens. Taurus_UMD|evm.model.AC_000175.1.1146 P59901 LIRA4_HUMAN 46.825 0.448905 0.549098 LILRA4 - Leukocyte immunoglobulin-like receptor subfamily A member 4 precursor - Homo sapiens (Human) - LILRA4 gene Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760). Taurus_UMD|evm.model.AC_000175.1.1147 Q9NX02 NALP2_HUMAN 64.368 0.994279 0.822976 NLRP2 - NACHT, LRR and PYD domains-containing protein 2 - Homo sapiens (Human) - NLRP2 gene Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Taurus_UMD|evm.model.AC_000175.1.1148 Q9HCN6 GPVI_HUMAN 72.727 0.983673 0.722714 GP6 - Platelet glycoprotein VI precursor - Homo sapiens (Human) - GP6 gene Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. Taurus_UMD|evm.model.AC_000175.1.1149 Q8WX94 NALP7_HUMAN 64.163 0.880682 0.538776 NLRP7 - NACHT, LRR and PYD domains-containing protein 7 - Homo sapiens (Human) - NLRP7 gene Inhibits CASP1/caspase-1-dependent IL1B secretion. Taurus_UMD|evm.model.AC_000175.1.1150 Q9H7L2 KI3X1_HUMAN 49.508 0.660333 1.19602 KIR3DX1 - Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 precursor - Homo sapiens (Human) - KIR3DX1 gene Taurus_UMD|evm.model.AC_000175.1.1151 Q8NHL6 LIRB1_HUMAN 48.210 0.552778 1.10769 LILRB1 - Leukocyte immunoglobulin-like receptor subfamily B member 1 precursor - Homo sapiens (Human) - LILRB1 gene Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:29262349, PubMed:19304799). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251). Taurus_UMD|evm.model.AC_000175.1.1152 O75022 LIRB3_HUMAN 62.559 0.913333 0.713154 LILRB3 - Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor - Homo sapiens (Human) - LILRB3 gene May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). Taurus_UMD|evm.model.AC_000175.1.1153 Q6ISS4 LAIR2_HUMAN 53.390 0.441065 1.73026 LAIR2 - Leukocyte-associated immunoglobulin-like receptor 2 precursor - Homo sapiens (Human) - LAIR2 gene extracellular region, regulation of immune response Taurus_UMD|evm.model.AC_000175.1.1154 Q2KJ98 TTYH1_BOVIN 99.778 0.995565 1.00222 TTYH1 - Protein tweety homolog 1 - Bos taurus (Bovine) - TTYH1 gene Probable chloride channel. May be involved in cell adhesion (By similarity). Taurus_UMD|evm.model.AC_000175.1.1155 Q96PV6 LENG8_HUMAN 92.125 0.997468 0.9875 LENG8 - Leukocyte receptor cluster member 8 - Homo sapiens (Human) - LENG8 gene nucleus Taurus_UMD|evm.model.AC_000175.1.1156 Q8BTN6 LENG9_MOUSE 56.480 0.94403 1.10515 Leng9 - Leukocyte receptor cluster member 9 - Mus musculus (Mouse) - Leng9 gene Taurus_UMD|evm.model.AC_000175.1.1157 Q6NZY7 BORG3_HUMAN 83.660 0.987013 1.04054 CDC42EP5 - Cdc42 effector protein 5 - Homo sapiens (Human) - CDC42EP5 gene Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity). Taurus_UMD|evm.model.AC_000175.1.1158 Q8MJZ2 LIRA6_PANTR 63.457 0.634223 1.32432 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Pan troglodytes (Chimpanzee) - LILRA6 gene May act as receptor for class I MHC antigens. Taurus_UMD|evm.model.AC_000175.1.1159 Q8NHJ6 LIRB4_HUMAN 52.232 0.841509 0.591518 LILRB4 - Leukocyte immunoglobulin-like receptor subfamily B member 4 precursor - Homo sapiens (Human) - LILRB4 gene Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Taurus_UMD|evm.model.AC_000175.1.1160 Q8MJZ2 LIRA6_PANTR 64.059 0.521073 1.62786 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Pan troglodytes (Chimpanzee) - LILRA6 gene May act as receptor for class I MHC antigens. Taurus_UMD|evm.model.AC_000175.1.1161 O75022 LIRB3_HUMAN 66.114 0.869835 0.767036 LILRB3 - Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor - Homo sapiens (Human) - LILRB3 gene May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). Taurus_UMD|evm.model.AC_000175.1.1162 Q6PI73 LIRA6_HUMAN 64.235 0.761221 1.158 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Homo sapiens (Human) - LILRA6 gene May act as receptor for class I MHC antigens. Taurus_UMD|evm.model.AC_000175.1.1163 Q6PI73 LIRA6_HUMAN 62.759 0.428854 2.10395 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Homo sapiens (Human) - LILRA6 gene May act as receptor for class I MHC antigens. Taurus_UMD|evm.model.AC_000175.1.1164 Q8MJZ2 LIRA6_PANTR 51.059 0.88964 0.923077 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Pan troglodytes (Chimpanzee) - LILRA6 gene May act as receptor for class I MHC antigens. Taurus_UMD|evm.model.AC_000175.1.1165 O75022 LIRB3_HUMAN 62.441 0.915948 0.735341 LILRB3 - Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor - Homo sapiens (Human) - LILRB3 gene May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). Taurus_UMD|evm.model.AC_000175.1.1166 Q8MJZ2 LIRA6_PANTR 63.570 0.541833 1.56549 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Pan troglodytes (Chimpanzee) - LILRA6 gene May act as receptor for class I MHC antigens. Taurus_UMD|evm.model.AC_000175.1.1167 O75022 LIRB3_HUMAN 62.295 0.869835 0.767036 LILRB3 - Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor - Homo sapiens (Human) - LILRB3 gene May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). Taurus_UMD|evm.model.AC_000175.1.1168 Q6PI73 LIRA6_HUMAN 64.235 0.761221 1.158 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Homo sapiens (Human) - LILRA6 gene May act as receptor for class I MHC antigens. Taurus_UMD|evm.model.AC_000175.1.1169 Q6PI73 LIRA6_HUMAN 66.106 0.689369 1.25156 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Homo sapiens (Human) - LILRA6 gene May act as receptor for class I MHC antigens. Taurus_UMD|evm.model.AC_000175.1.1170 Q8N149 LIRA2_HUMAN 50.000 0.727434 1.16977 LILRA2 - Leukocyte immunoglobulin-like receptor subfamily A member 2 precursor - Homo sapiens (Human) - LILRA2 gene Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061). Taurus_UMD|evm.model.AC_000175.1.1171 P29314 RS9_RAT 100.000 0.989744 1.00515 Rps9 - 40S ribosomal protein S9 - Rattus norvegicus (Rat) - Rps9 gene cytoplasm, cytosolic small ribosomal subunit, nucleolus, ribonucleoprotein complex, small ribosomal subunit, synapse, 5.8S rRNA binding, rRNA binding, structural constituent of ribosome, translation regulator activity Taurus_UMD|evm.model.AC_000175.1.1172 Q9BSV6 SEN34_HUMAN 90.997 0.817942 1.22258 TSEN34 - tRNA-splicing endonuclease subunit Sen34 - Homo sapiens (Human) - TSEN34 gene Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Taurus_UMD|evm.model.AC_000175.1.1173 Q0VCY6 MBOA7_BOVIN 100.000 0.995772 1.00212 MBOAT7 - Lysophospholipid acyltransferase 7 - Bos taurus (Bovine) - MBOAT7 gene Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell. In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation. Taurus_UMD|evm.model.AC_000175.1.1174 Q7Z404 TMC4_HUMAN 80.899 0.997167 0.991573 TMC4 - Transmembrane channel-like protein 4 - Homo sapiens (Human) - TMC4 gene Probable ion channel. Taurus_UMD|evm.model.AC_000175.1.1175 Q3T0Z5 LENG1_BOVIN 100.000 0.992424 1.0038 LENG1 - Leukocyte receptor cluster member 1 homolog - Bos taurus (Bovine) - LENG1 gene Taurus_UMD|evm.model.AC_000175.1.1176 O75175 CNOT3_HUMAN 93.891 0.997315 0.989376 CNOT3 - CCR4-NOT transcription complex subunit 3 - Homo sapiens (Human) - CNOT3 gene Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. Taurus_UMD|evm.model.AC_000175.1.1177 Q8WWY3 PRP31_HUMAN 99.399 0.996 1.002 PRPF31 - U4/U6 small nuclear ribonucleoprotein Prp31 - Homo sapiens (Human) - PRPF31 gene Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). Taurus_UMD|evm.model.AC_000175.1.1178 Q17QH7 TFPT_BOVIN 100.000 0.992063 1.00398 TFPT - TCF3 fusion partner homolog - Bos taurus (Bovine) - TFPT gene Appears to promote apoptosis in a p53/TP53-independent manner. Taurus_UMD|evm.model.AC_000175.1.1179 Q02371 NDUA3_BOVIN 100.000 0.976471 1.0119 NDUFA3 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 - Bos taurus (Bovine) - NDUFA3 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000175.1.1180 Q8IYS5 OSCAR_HUMAN 69.835 0.84507 1.00709 OSCAR - Osteoclast-associated immunoglobulin-like receptor precursor - Homo sapiens (Human) - OSCAR gene Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Taurus_UMD|evm.model.AC_000175.1.1181 Q2TBQ5 RL7A_BOVIN 68.750 0.110028 2.69925 RPL7A - 60S ribosomal protein L7a - Bos taurus (Bovine) - RPL7A gene cytosolic large ribosomal subunit, RNA binding, maturation of LSU-rRNA Taurus_UMD|evm.model.AC_000175.1.1182 Q7Z5H5 VN1R4_HUMAN 38.596 0.655738 1.4186 VN1R4 - Vomeronasal type-1 receptor 4 - Homo sapiens (Human) - VN1R4 gene Putative pheromone receptor. Taurus_UMD|evm.model.AC_000175.1.1183 Q7Z5H5 VN1R4_HUMAN 35.897 0.980519 0.511628 VN1R4 - Vomeronasal type-1 receptor 4 - Homo sapiens (Human) - VN1R4 gene Putative pheromone receptor. Taurus_UMD|evm.model.AC_000175.1.1184 Q86W25 NAL13_HUMAN 44.699 0.297251 1.11601 NLRP13 - NACHT, LRR and PYD domains-containing protein 13 - Homo sapiens (Human) - NLRP13 gene Involved in inflammation. Taurus_UMD|evm.model.AC_000175.1.1185 Q86W28 NALP8_HUMAN 54.564 0.906998 1.03626 NLRP8 - NACHT, LRR and PYD domains-containing protein 8 - Homo sapiens (Human) - NLRP8 gene Involved in inflammation. Taurus_UMD|evm.model.AC_000175.1.1186 Q647I9 NALP5_BOVIN 99.454 0.99818 1.00091 NLRP5 - NACHT, LRR and PYD domains-containing protein 5 - Bos taurus (Bovine) - NLRP5 gene As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the formation of F-actin cytoplasmic lattices (CPL) in oocytes, which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold (By similarity). Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum (ER) storage via regulation of ER cellular localization (By similarity). May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation (By similarity). Taurus_UMD|evm.model.AC_000175.1.1187 Q6DD87 ZN787_HUMAN 93.229 0.481761 2.08115 ZNF787 - Zinc finger protein 787 - Homo sapiens (Human) - ZNF787 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1188 Q8N0Y2 ZN444_HUMAN 84.615 0.25 0.782875 ZNF444 - Zinc finger protein 444 - Homo sapiens (Human) - ZNF444 gene Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter. Taurus_UMD|evm.model.AC_000175.1.1189 A1YFW2 ZSC12_PANPA 52.475 0.247525 0.668874 ZSCAN12 - Zinc finger and SCAN domain-containing protein 12 - Pan paniscus (Pygmy chimpanzee) - ZSCAN12 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1190 Q9BUG6 ZSA5A_HUMAN 52.778 0.176617 0.810484 ZSCAN5A - Zinc finger and SCAN domain-containing protein 5A - Homo sapiens (Human) - ZSCAN5A gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1191 B0JZ89 FA32A_XENTR 93.103 0.77027 0.660714 fam32a - Protein FAM32A - Xenopus tropicalis (Western clawed frog) - fam32a gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Taurus_UMD|evm.model.AC_000175.1.1192 Q5R9E5 FA32A_PONAB 78.761 0.955752 1.00893 FAM32A - Protein FAM32A - Pongo abelii (Sumatran orangutan) - FAM32A gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Taurus_UMD|evm.model.AC_000175.1.1193 Q9BUG6 ZSA5A_HUMAN 54.545 0.204301 0.75 ZSCAN5A - Zinc finger and SCAN domain-containing protein 5A - Homo sapiens (Human) - ZSCAN5A gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1194 O43309 ZSC12_HUMAN 53.211 0.27907 0.640728 ZSCAN12 - Zinc finger and SCAN domain-containing protein 12 - Homo sapiens (Human) - ZSCAN12 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1195 A6NGD5 ZSA5C_HUMAN 53.939 0.896175 0.368952 ZSCAN5C - Zinc finger and SCAN domain-containing protein 5C - Homo sapiens (Human) - ZSCAN5C gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1196 A6NGD5 ZSA5C_HUMAN 61.538 0.179567 1.30242 ZSCAN5C - Zinc finger and SCAN domain-containing protein 5C - Homo sapiens (Human) - ZSCAN5C gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1197 Q9BUG6 ZSA5A_HUMAN 54.167 0.191375 0.747984 ZSCAN5A - Zinc finger and SCAN domain-containing protein 5A - Homo sapiens (Human) - ZSCAN5A gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1198 B0JZ89 FA32A_XENTR 91.379 0.77027 0.660714 fam32a - Protein FAM32A - Xenopus tropicalis (Western clawed frog) - fam32a gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Taurus_UMD|evm.model.AC_000175.1.1199 Q5R9E5 FA32A_PONAB 79.646 0.956897 1.03571 FAM32A - Protein FAM32A - Pongo abelii (Sumatran orangutan) - FAM32A gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Taurus_UMD|evm.model.AC_000175.1.1200 P0CG00 ZSA5D_HUMAN 55.000 0.298193 0.668008 ZSCAN5DP - Putative zinc finger and SCAN domain-containing protein 5D - Homo sapiens (Human) - ZSCAN5DP gene DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000175.1.1201 Q5R670 ZKSC1_PONAB 50.575 0.185745 0.82238 ZKSCAN1 - Zinc finger protein with KRAB and SCAN domains 1 - Pongo abelii (Sumatran orangutan) - ZKSCAN1 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1202 Q5R9E5 FA32A_PONAB 74.194 0.923077 0.580357 FAM32A - Protein FAM32A - Pongo abelii (Sumatran orangutan) - FAM32A gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Taurus_UMD|evm.model.AC_000175.1.1203 A2T6W2 ZN449_PANTR 50.602 0.181416 0.872587 ZNF449 - Zinc finger protein 449 - Pan troglodytes (Chimpanzee) - ZNF449 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1204 Q5HYK9 ZN667_HUMAN 86.557 0.915789 1.09016 ZNF667 - Zinc finger protein 667 - Homo sapiens (Human) - ZNF667 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1205 Q96ND8 ZN583_HUMAN 89.576 0.9523 1.03163 ZNF583 - Zinc finger protein 583 - Homo sapiens (Human) - ZNF583 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1206 Q5R9E5 FA32A_PONAB 83.186 0.956897 1.03571 FAM32A - Protein FAM32A - Pongo abelii (Sumatran orangutan) - FAM32A gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Taurus_UMD|evm.model.AC_000175.1.1207 B0JZ89 FA32A_XENTR 87.931 0.77027 0.660714 fam32a - Protein FAM32A - Xenopus tropicalis (Western clawed frog) - fam32a gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Taurus_UMD|evm.model.AC_000175.1.1208 Q96NG8 ZN582_HUMAN 88.008 0.652339 1.52998 ZNF582 - Zinc finger protein 582 - Homo sapiens (Human) - ZNF582 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1209 Q9HCL3 ZFP14_HUMAN 53.333 0.642578 0.9606 ZFP14 - Zinc finger protein 14 homolog - Homo sapiens (Human) - ZFP14 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1211 P0DL12 SIM17_HUMAN 78.814 0.982906 0.991525 SMIM17 - Small integral membrane protein 17 - Homo sapiens (Human) - SMIM17 gene Taurus_UMD|evm.model.AC_000175.1.1212 Q6ZN57 ZFP2_HUMAN 74.084 0.900709 0.91757 ZFP2 - Zinc finger protein 2 homolog - Homo sapiens (Human) - ZFP2 gene Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance. Taurus_UMD|evm.model.AC_000175.1.1214 Q6ECI4 ZN470_HUMAN 87.033 0.911871 0.775453 ZNF470 - Zinc finger protein 470 - Homo sapiens (Human) - ZNF470 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1215 Q8NHY6 ZFP28_HUMAN 73.948 0.993169 0.843318 ZFP28 - Zinc finger protein 28 homolog - Homo sapiens (Human) - ZFP28 gene May be involved in transcriptional regulation. May have a role in embryonic development. Taurus_UMD|evm.model.AC_000175.1.1216 Q9Y2P0 ZN835_HUMAN 66.165 0.895093 1.10056 ZNF835 - Zinc finger protein 835 - Homo sapiens (Human) - ZNF835 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1218 Q9NZV7 ZIM2_HUMAN 54.270 0.943548 0.705882 ZIM2 - Zinc finger imprinted 2 - Homo sapiens (Human) - ZIM2 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1219 A2T812 ZN287_PONPY 53.271 0.569892 0.244415 ZNF287 - Zinc finger protein 287 - Pongo pygmaeus (Bornean orangutan) - ZNF287 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1222 Q6H236 PEG3_BOVIN 97.149 0.995816 0.200251 PEG3 - Paternally-expressed gene 3 protein - Bos taurus (Bovine) - PEG3 gene Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Taurus_UMD|evm.model.AC_000175.1.1223 Q6H236 PEG3_BOVIN 98.150 0.727592 0.715124 PEG3 - Paternally-expressed gene 3 protein - Bos taurus (Bovine) - PEG3 gene Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Taurus_UMD|evm.model.AC_000175.1.1225 A6NLW8 DUXA_HUMAN 73.134 0.634615 0.509804 DUXA - Double homeobox protein A - Homo sapiens (Human) - DUXA gene Putative transcription factor. Taurus_UMD|evm.model.AC_000175.1.1226 Q9UQB9 AURKC_HUMAN 87.313 0.853035 1.01294 AURKC - Aurora kinase C - Homo sapiens (Human) - AURKC gene Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. Taurus_UMD|evm.model.AC_000175.1.1227 Q5CZA5 ZN805_HUMAN 86.443 0.995231 1.00319 ZNF805 - Zinc finger protein 805 - Homo sapiens (Human) - ZNF805 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1228 O43296 ZN264_HUMAN 83.522 0.939117 1.04785 ZNF264 - Zinc finger protein 264 - Homo sapiens (Human) - ZNF264 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1229 Q08DG8 ZN135_BOVIN 57.529 0.570796 0.687976 ZNF135 - Zinc finger protein 135 - Bos taurus (Bovine) - ZNF135 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1230 Q9HCX3 ZN304_HUMAN 81.571 0.727974 1.37785 ZNF304 - Zinc finger protein 304 - Homo sapiens (Human) - ZNF304 gene Acts as transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites (PubMed:24623306). Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways (PubMed:26081979). Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression (PubMed:26081979). Promotes angiogenesis (PubMed:26081979). Promotes tumor growth (PubMed:24623306, PubMed:26081979). Taurus_UMD|evm.model.AC_000175.1.1231 P17021 ZNF17_HUMAN 48.795 0.982036 0.252266 ZNF17 - Zinc finger protein 17 - Homo sapiens (Human) - ZNF17 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1232 Q4R723 RL27A_MACFA 65.753 0.420896 2.26351 RPL27A - 60S ribosomal protein L27a - Macaca fascicularis (Crab-eating macaque) - RPL27A gene Taurus_UMD|evm.model.AC_000175.1.1233 Q9BWM5 ZN416_HUMAN 54.150 0.556291 0.762626 ZNF416 - Zinc finger protein 416 - Homo sapiens (Human) - ZNF416 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1234 Q8NEK5 ZN548_HUMAN 60.590 0.984536 1.09193 ZNF548 - Zinc finger protein 548 - Homo sapiens (Human) - ZNF548 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1235 Q8TF45 ZN418_HUMAN 56.089 0.517241 0.772189 ZNF418 - Zinc finger protein 418 - Homo sapiens (Human) - ZNF418 gene Transcriptional repressor. Taurus_UMD|evm.model.AC_000175.1.1236 Q9HCX3 ZN304_HUMAN 64.305 0.901685 0.540212 ZNF304 - Zinc finger protein 304 - Homo sapiens (Human) - ZNF304 gene Acts as transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites (PubMed:24623306). Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways (PubMed:26081979). Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression (PubMed:26081979). Promotes angiogenesis (PubMed:26081979). Promotes tumor growth (PubMed:24623306, PubMed:26081979). Taurus_UMD|evm.model.AC_000175.1.1237 Q8NEK5 ZN548_HUMAN 51.052 0.975701 1.00375 ZNF548 - Zinc finger protein 548 - Homo sapiens (Human) - ZNF548 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1238 Q68DY9 ZN772_HUMAN 61.677 0.894879 0.758691 ZNF772 - Zinc finger protein 772 - Homo sapiens (Human) - ZNF772 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1239 Q6PK81 ZN773_HUMAN 72.907 0.887526 1.10633 ZNF773 - Zinc finger protein 773 - Homo sapiens (Human) - ZNF773 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1241 Q7Z398 ZN550_HUMAN 73.723 0.623077 1.54028 ZNF550 - Zinc finger protein 550 - Homo sapiens (Human) - ZNF550 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1242 Q9HCX3 ZN304_HUMAN 52.299 0.621864 0.846737 ZNF304 - Zinc finger protein 304 - Homo sapiens (Human) - ZNF304 gene Acts as transcriptional regulator and plays a role in gene silencing (PubMed:24623306, PubMed:26081979). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) (PubMed:24623306) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites (PubMed:24623306). Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways (PubMed:26081979). Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression (PubMed:26081979). Promotes angiogenesis (PubMed:26081979). Promotes tumor growth (PubMed:24623306, PubMed:26081979). Taurus_UMD|evm.model.AC_000175.1.1243 Q9BWM5 ZN416_HUMAN 57.841 0.99661 0.993266 ZNF416 - Zinc finger protein 416 - Homo sapiens (Human) - ZNF416 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1246 D2HQI1 ZSCA4_AILME 61.129 0.808399 0.886047 ZSCAN4 - Zinc finger and SCAN domain-containing protein 4 - Ailuropoda melanoleuca (Giant panda) - ZSCAN4 gene Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity). Taurus_UMD|evm.model.AC_000175.1.1247 Q3KQV3 ZN792_HUMAN 77.778 0.266332 0.314873 ZNF792 - Zinc finger protein 792 - Homo sapiens (Human) - ZNF792 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1248 P52741 ZN134_HUMAN 83.684 0.994737 0.88993 ZNF134 - Zinc finger protein 134 - Homo sapiens (Human) - ZNF134 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1250 Q7Z340 ZN551_HUMAN 53.435 0.257937 0.752239 ZNF551 - Zinc finger protein 551 - Homo sapiens (Human) - ZNF551 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1251 A8MQ14 ZN850_HUMAN 55.220 0.879346 0.448624 ZNF850 - Zinc finger protein 850 - Homo sapiens (Human) - ZNF850 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1252 Q9Y2P7 ZN256_HUMAN 50.175 0.762735 1.18979 ZNF256 - Zinc finger protein 256 - Homo sapiens (Human) - ZNF256 gene Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity. Taurus_UMD|evm.model.AC_000175.1.1253 Q13398 ZN211_HUMAN 49.585 0.891993 0.952128 ZNF211 - Zinc finger protein 211 - Homo sapiens (Human) - ZNF211 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1254 Q13398 ZN211_HUMAN 71.233 0.923077 0.138298 ZNF211 - Zinc finger protein 211 - Homo sapiens (Human) - ZNF211 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1255 Q6P9A1 ZN530_HUMAN 54.983 0.533088 0.90818 ZNF530 - Zinc finger protein 530 - Homo sapiens (Human) - ZNF530 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1256 Q13398 ZN211_HUMAN 54.516 0.519328 1.05496 ZNF211 - Zinc finger protein 211 - Homo sapiens (Human) - ZNF211 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1257 Q13398 ZN211_HUMAN 77.821 0.988327 0.911348 ZNF211 - Zinc finger protein 211 - Homo sapiens (Human) - ZNF211 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1258 Q13398 ZN211_HUMAN 59.594 0.955307 0.952128 ZNF211 - Zinc finger protein 211 - Homo sapiens (Human) - ZNF211 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1259 D2HQI1 ZSCA4_AILME 73.000 0.334459 0.688372 ZSCAN4 - Zinc finger and SCAN domain-containing protein 4 - Ailuropoda melanoleuca (Giant panda) - ZSCAN4 gene Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity). Taurus_UMD|evm.model.AC_000175.1.1260 P18621 RL17_HUMAN 92.308 0.978261 0.5 RPL17 - 60S ribosomal protein L17 - Homo sapiens (Human) - RPL17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000175.1.1261 Q13106 ZN154_HUMAN 66.599 0.993939 1.13272 ZNF154 - Zinc finger protein 154 - Homo sapiens (Human) - ZNF154 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1263 Q7Z340 ZN551_HUMAN 53.943 0.62423 0.726866 ZNF551 - Zinc finger protein 551 - Homo sapiens (Human) - ZNF551 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1264 P02301 H3C_MOUSE 93.382 0.985401 1.00735 H3-5 - Histone H3.3C - Mus musculus (Mouse) - H3-5 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000175.1.1265 A8MQ14 ZN850_HUMAN 56.129 0.750754 0.912844 ZNF850 - Zinc finger protein 850 - Homo sapiens (Human) - ZNF850 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1266 Q68DI1 ZN776_HUMAN 73.585 0.722222 0.138996 ZNF776 - Zinc finger protein 776 - Homo sapiens (Human) - ZNF776 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1267 Q13106 ZN154_HUMAN 78.846 0.272727 0.427918 ZNF154 - Zinc finger protein 154 - Homo sapiens (Human) - ZNF154 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1268 P05386 RLA1_HUMAN 67.544 0.86 0.877193 RPLP1 - 60S acidic ribosomal protein P1 - Homo sapiens (Human) - RPLP1 gene Plays an important role in the elongation step of protein synthesis. Taurus_UMD|evm.model.AC_000175.1.1269 Q9Y2P7 ZN256_HUMAN 56.778 0.947853 1.03987 ZNF256 - Zinc finger protein 256 - Homo sapiens (Human) - ZNF256 gene Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity. Taurus_UMD|evm.model.AC_000175.1.1270 A8MQ14 ZN850_HUMAN 54.785 0.698068 0.759633 ZNF850 - Zinc finger protein 850 - Homo sapiens (Human) - ZNF850 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1271 E7ETH6 Z587B_HUMAN 50.909 0.427083 0.955224 ZNF587B - Zinc finger protein 587B - Homo sapiens (Human) - ZNF587B gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1272 Q15370 ELOB_HUMAN 96.610 0.983193 1.00847 ELOB - Elongin-B - Homo sapiens (Human) - ELOB gene SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). Taurus_UMD|evm.model.AC_000175.1.1273 Q8WXB4 ZN606_HUMAN 81.315 0.531599 0.679293 ZNF606 - Zinc finger protein 606 - Homo sapiens (Human) - ZNF606 gene May act as a transcriptional repressor. Taurus_UMD|evm.model.AC_000175.1.1274 Q08DG8 ZN135_BOVIN 100.000 0.99696 1.00152 ZNF135 - Zinc finger protein 135 - Bos taurus (Bovine) - ZNF135 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1276 Q86UD4 ZN329_HUMAN 79.104 0.992579 0.996303 ZNF329 - Zinc finger protein 329 - Homo sapiens (Human) - ZNF329 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1277 A6QPT6 ZN274_BOVIN 100.000 0.859722 1.16129 ZNF274 - Neurotrophin receptor-interacting factor homolog - Bos taurus (Bovine) - ZNF274 gene Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity). Taurus_UMD|evm.model.AC_000175.1.1278 P17098 ZNF8_HUMAN 65.858 0.99635 0.953043 ZNF8 - Zinc finger protein 8 - Homo sapiens (Human) - ZNF8 gene Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins. Taurus_UMD|evm.model.AC_000175.1.1279 P10073 ZSC22_HUMAN 74.317 0.765957 0.478615 ZSCAN22 - Zinc finger and SCAN domain-containing protein 22 - Homo sapiens (Human) - ZSCAN22 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1280 Q2KJF1 A1BG_BOVIN 100.000 0.996032 1.00199 A1BG - Alpha-1B-glycoprotein precursor - Bos taurus (Bovine) - A1BG gene Taurus_UMD|evm.model.AC_000175.1.1281 P46782 RS5_HUMAN 100.000 0.707317 1.40686 RPS5 - 40S ribosomal protein S5 - Homo sapiens (Human) - RPS5 gene cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleoplasm, ribonucleoprotein complex, ribosome, mRNA binding Taurus_UMD|evm.model.AC_000175.1.1283 Q8IVC4 ZN584_HUMAN 62.563 0.802548 1.11876 ZNF584 - Zinc finger protein 584 - Homo sapiens (Human) - ZNF584 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1284 P52740 ZN132_HUMAN 71.650 0.967123 1.03399 ZNF132 - Zinc finger protein 132 - Homo sapiens (Human) - ZNF132 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1285 Q6AW86 Z324B_HUMAN 72.039 0.829431 1.09926 ZNF324B - Zinc finger protein 324B - Homo sapiens (Human) - ZNF324B gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1286 Q9NWS9 ZN446_HUMAN 62.857 0.879733 0.997778 ZNF446 - Zinc finger protein 446 - Homo sapiens (Human) - ZNF446 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000175.1.1287 Q9Y2P5 S27A5_HUMAN 77.027 0.976505 0.986957 SLC27A5 - Bile acyl-CoA synthetase - Homo sapiens (Human) - SLC27A5 gene Acyl-CoA synthetase that catalyzes the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:10749848, PubMed:11980911). Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (PubMed:10749848, PubMed:11980911). Also exhibits acyl CoA synthetase activity that activates very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (PubMed:10479480). In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). Exhibits long-chain fatty acids (LCFA) transport activity (PubMed:20530735). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity). Taurus_UMD|evm.model.AC_000175.1.1288 Q96K62 ZBT45_HUMAN 85.000 0.715385 0.763209 ZBTB45 - Zinc finger and BTB domain-containing protein 45 - Homo sapiens (Human) - ZBTB45 gene May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (By similarity). Taurus_UMD|evm.model.AC_000175.1.1289 Q13263 TIF1B_HUMAN 95.983 0.969044 0.88982 TRIM28 - Transcription intermediary factor 1-beta - Homo sapiens (Human) - TRIM28 gene Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Acts as a corepressor for ZFP568 (By similarity). Taurus_UMD|evm.model.AC_000175.1.1290 Q9DB34 CHM2A_MOUSE 98.649 0.991031 1.0045 Chmp2a - Charged multivesicular body protein 2a - Mus musculus (Mouse) - Chmp2a gene Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Taurus_UMD|evm.model.AC_000175.1.1291 P61082 UBC12_MOUSE 100.000 0.98913 1.00546 Ube2m - NEDD8-conjugating enzyme Ubc12 - Mus musculus (Mouse) - Ube2m gene Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. Taurus_UMD|evm.model.AC_000175.1.1293 P28698 MZF1_HUMAN 81.793 0.997279 1.00136 MZF1 - Myeloid zinc finger 1 - Homo sapiens (Human) - MZF1 gene Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development. Taurus_UMD|evm.model.AC_000175.1.1294 B2RD01 CENP1_HUMAN 48.404 0.293269 3.3369 CENPBD1 - CENPB DNA-binding domain-containing protein 1 - Homo sapiens (Human) - CENPBD1 gene Taurus_UMD|evm.model.AC_000175.1.1295 Q96MW7 TIGD1_HUMAN 44.465 0.710991 1.24704 TIGD1 - Tigger transposable element-derived protein 1 - Homo sapiens (Human) - TIGD1 gene nucleus, DNA binding Taurus_UMD|evm.model.AC_000176.1.2 Q8NH72 OR4C6_HUMAN 73.469 0.96 0.161812 OR4C6 - Olfactory receptor 4C6 - Homo sapiens (Human) - OR4C6 gene Odorant receptor. Taurus_UMD|evm.model.AC_000176.1.4 A0JN41 CAH10_BOVIN 99.580 0.959514 0.753049 CA10 - Carbonic anhydrase-related protein 10 - Bos taurus (Bovine) - CA10 gene Does not have a catalytic activity. Taurus_UMD|evm.model.AC_000176.1.5 A0JN41 CAH10_BOVIN 100.000 0.989247 0.283537 CA10 - Carbonic anhydrase-related protein 10 - Bos taurus (Bovine) - CA10 gene Does not have a catalytic activity. Taurus_UMD|evm.model.AC_000176.1.6 P23588 IF4B_HUMAN 84.211 0.651163 0.281506 EIF4B - Eukaryotic translation initiation factor 4B - Homo sapiens (Human) - EIF4B gene Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. Taurus_UMD|evm.model.AC_000176.1.8 Q32L59 TMC5B_BOVIN 100.000 0.0725126 1.68946 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Taurus_UMD|evm.model.AC_000176.1.9 P19419 ELK1_HUMAN 87.500 0.88806 0.313084 ELK1 - ETS domain-containing protein Elk-1 - Homo sapiens (Human) - ELK1 gene Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity). Taurus_UMD|evm.model.AC_000176.1.11 Q719N3 PAQRB_RAT 72.368 0.6 0.52521 Mmd - Monocyte to macrophage differentiation factor - Rattus norvegicus (Rat) - Mmd gene Is involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion. Taurus_UMD|evm.model.AC_000176.1.12 A0A075B6I7 LV548_HUMAN 74.286 0.722222 1.37143 IGLV5-48 - Probable non-functional immunoglobulin lambda variable 5-48 precursor - Homo sapiens (Human) - IGLV5-48 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Taurus_UMD|evm.model.AC_000176.1.14 Q13352 CENPR_HUMAN 66.258 0.877907 0.971751 ITGB3BP - Centromere protein R - Homo sapiens (Human) - ITGB3BP gene Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Taurus_UMD|evm.model.AC_000176.1.15 A6H750 KIF2B_BOVIN 99.561 0.997076 1.00146 KIF2B - Kinesin-like protein KIF2B - Bos taurus (Bovine) - KIF2B gene Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement during mitosis. Has microtubule depolymerization activity. Plays a role in chromosome congression. Taurus_UMD|evm.model.AC_000176.1.16 P39872 RL3_BOVIN 70.000 0.927083 0.238213 RPL3 - 60S ribosomal protein L3 - Bos taurus (Bovine) - RPL3 gene The L3 protein is a component of the large subunit of cytoplasmic ribosomes. Taurus_UMD|evm.model.AC_000176.1.17 Q29293 RL3_PIG 45.545 0.900901 0.853846 RPL3 - 60S ribosomal protein L3 - Sus scrofa (Pig) - RPL3 gene The L3 protein is a component of the large subunit of cytoplasmic ribosomes. Taurus_UMD|evm.model.AC_000176.1.18 Q0ZQK3 PPIA_SAGOE 81.416 0.760274 0.890244 PPIA - Peptidyl-prolyl cis-trans isomerase A - Saguinus oedipus (Cotton-top tamarin) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Taurus_UMD|evm.model.AC_000176.1.19 O75674 TM1L1_HUMAN 84.778 0.987342 0.995798 TOM1L1 - TOM1-like protein 1 - Homo sapiens (Human) - TOM1L1 gene Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity). Taurus_UMD|evm.model.AC_000176.1.20 A3KMZ6 COX11_BOVIN 99.645 0.992933 1.00355 COX11 - Cytochrome c oxidase assembly protein COX11, mitochondrial precursor - Bos taurus (Bovine) - COX11 gene Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. Taurus_UMD|evm.model.AC_000176.1.21 Q6ZWJ1 STXB4_HUMAN 91.304 0.426667 0.678119 STXBP4 - Syntaxin-binding protein 4 - Homo sapiens (Human) - STXBP4 gene Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). Taurus_UMD|evm.model.AC_000176.1.23 O75718 CRTAP_HUMAN 71.951 0.994987 0.995012 CRTAP - Cartilage-associated protein precursor - Homo sapiens (Human) - CRTAP gene Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues. Taurus_UMD|evm.model.AC_000176.1.24 Q16534 HLF_HUMAN 97.966 0.993243 1.00339 HLF - Hepatic leukemia factor - Homo sapiens (Human) - HLF gene chromatin, nucleoplasm, nucleus, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, double-stranded DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding Taurus_UMD|evm.model.AC_000176.1.25 Q15546 PAQRB_HUMAN 98.253 0.820144 1.16807 MMD - Monocyte to macrophage differentiation factor - Homo sapiens (Human) - MMD gene Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion. Taurus_UMD|evm.model.AC_000176.1.26 A0A1B0GRQ0 SIM36_MOUSE 77.419 0.978723 1.01075 SMIM36 - Small integral membrane protein 36 - Mus musculus (Mouse) - SMIM36 gene Taurus_UMD|evm.model.AC_000176.1.27 Q2KIC8 TM100_BOVIN 100.000 0.985185 1.00746 TMEM100 - Transmembrane protein 100 - Bos taurus (Bovine) - TMEM100 gene Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. Taurus_UMD|evm.model.AC_000176.1.28 P02720 PPCT_BOVIN 60.849 0.981308 1.00469 PCTP - Phosphatidylcholine transfer protein - Bos taurus (Bovine) - PCTP gene Catalyzes the transfer of phosphatidylcholine between membranes. Binds phosphatidylcholine in a tight 1:1 stoichiometric complex. Taurus_UMD|evm.model.AC_000176.1.29 P02720 PPCT_BOVIN 61.792 0.981308 1.00469 PCTP - Phosphatidylcholine transfer protein - Bos taurus (Bovine) - PCTP gene Catalyzes the transfer of phosphatidylcholine between membranes. Binds phosphatidylcholine in a tight 1:1 stoichiometric complex. Taurus_UMD|evm.model.AC_000176.1.30 P02720 PPCT_BOVIN 100.000 0.990654 1.00469 PCTP - Phosphatidylcholine transfer protein - Bos taurus (Bovine) - PCTP gene Catalyzes the transfer of phosphatidylcholine between membranes. Binds phosphatidylcholine in a tight 1:1 stoichiometric complex. Taurus_UMD|evm.model.AC_000176.1.31 O43422 P52K_HUMAN 96.818 0.995465 0.579501 THAP12 - 52 kDa repressor of the inhibitor of the protein kinase - Homo sapiens (Human) - THAP12 gene Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. Taurus_UMD|evm.model.AC_000176.1.32 O43422 P52K_HUMAN 94.983 0.993333 0.394218 THAP12 - 52 kDa repressor of the inhibitor of the protein kinase - Homo sapiens (Human) - THAP12 gene Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. Taurus_UMD|evm.model.AC_000176.1.33 P02720 PPCT_BOVIN 70.000 0.448916 1.51643 PCTP - Phosphatidylcholine transfer protein - Bos taurus (Bovine) - PCTP gene Catalyzes the transfer of phosphatidylcholine between membranes. Binds phosphatidylcholine in a tight 1:1 stoichiometric complex. Taurus_UMD|evm.model.AC_000176.1.35 Q8N957 ANKF1_HUMAN 92.340 0.637681 1.44692 ANKFN1 - Ankyrin repeat and fibronectin type-III domain-containing protein 1 - Homo sapiens (Human) - ANKFN1 gene Taurus_UMD|evm.model.AC_000176.1.36 Q13253 NOGG_HUMAN 97.845 0.991416 1.00431 NOG - Noggin precursor - Homo sapiens (Human) - NOG gene Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732). Taurus_UMD|evm.model.AC_000176.1.38 P52429 DGKE_HUMAN 92.945 0.99646 0.996473 DGKE - Diacylglycerol kinase epsilon - Homo sapiens (Human) - DGKE gene Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15544348, PubMed:19744926, PubMed:22108654, PubMed:21477596, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:8626589, PubMed:15544348). Also plays an important role in the biosynthesis of complex lipids (PubMed:8626589). Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle (PubMed:19744926, PubMed:22108654, PubMed:23274426). Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently (PubMed:22108654). Taurus_UMD|evm.model.AC_000176.1.39 Q14258 TRI25_HUMAN 74.646 0.996835 1.00317 TRIM25 - E3 ubiquitin/ISG15 ligase TRIM25 - Homo sapiens (Human) - TRIM25 gene Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1 (PubMed:17392790, PubMed:30193849). Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Taurus_UMD|evm.model.AC_000176.1.40 P38432 COIL_HUMAN 74.739 0.996503 0.993056 COIL - Coilin - Homo sapiens (Human) - COIL gene Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. Taurus_UMD|evm.model.AC_000176.1.41 Q9HB40 RISC_HUMAN 79.646 0.995546 0.993363 SCPEP1 - Retinoid-inducible serine carboxypeptidase precursor - Homo sapiens (Human) - SCPEP1 gene May be involved in vascular wall and kidney homeostasis. Taurus_UMD|evm.model.AC_000176.1.42 O00303 EIF3F_HUMAN 63.077 0.537815 0.333333 EIF3F - Eukaryotic translation initiation factor 3 subunit F - Homo sapiens (Human) - EIF3F gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Taurus_UMD|evm.model.AC_000176.1.43 P10853 H2B1F_MOUSE 92.063 0.984252 1.00794 H2bc7 - Histone H2B type 1-F/J/L - Mus musculus (Mouse) - H2bc7 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000176.1.44 Q92667 AKAP1_HUMAN 68.357 0.99763 0.934662 AKAP1 - A-kinase anchor protein 1, mitochondrial precursor - Homo sapiens (Human) - AKAP1 gene Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). Taurus_UMD|evm.model.AC_000176.1.45 Q96DH6 MSI2H_HUMAN 99.660 0.901538 0.990854 MSI2 - RNA-binding protein Musashi homolog 2 - Homo sapiens (Human) - MSI2 gene RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). Taurus_UMD|evm.model.AC_000176.1.46 Q43083 H4_PYRSA 80.702 0.597826 0.893204 Histone H4 - Pyrenomonas salina Taurus_UMD|evm.model.AC_000176.1.47 A6NF36 CC182_HUMAN 84.211 0.980519 1.00654 CCDC182 - Coiled-coil domain-containing protein 182 - Homo sapiens (Human) - CCDC182 gene female gonad development Taurus_UMD|evm.model.AC_000176.1.48 Q2KID7 OSTC_BOVIN 88.158 0.974026 0.516779 OSTC - Oligosaccharyltransferase complex subunit OSTC - Bos taurus (Bovine) - OSTC gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. Taurus_UMD|evm.model.AC_000176.1.49 Q2NL27 RT23_BOVIN 99.474 0.989529 1.00526 MRPS23 - 28S ribosomal protein S23, mitochondrial - Bos taurus (Bovine) - MRPS23 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000176.1.51 Q9NWM3 CUED1_HUMAN 89.888 0.924084 0.989637 CUEDC1 - CUE domain-containing protein 1 - Homo sapiens (Human) - CUEDC1 gene Taurus_UMD|evm.model.AC_000176.1.52 Q14119 VEZF1_HUMAN 98.627 0.992141 0.976967 VEZF1 - Vascular endothelial zinc finger 1 - Homo sapiens (Human) - VEZF1 gene Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3. Taurus_UMD|evm.model.AC_000176.1.53 Q3YLA6 SRSF1_PIG 100.000 0.991968 1.00403 SRSF1 - Serine/arginine-rich splicing factor 1 - Sus scrofa (Pig) - SRSF1 gene Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway (By similarity). Taurus_UMD|evm.model.AC_000176.1.54 Q78P75 DYL2_RAT 100.000 0.290429 3.40449 Dynll2 - Dynein light chain 2, cytoplasmic - Rattus norvegicus (Rat) - Dynll2 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). Taurus_UMD|evm.model.AC_000176.1.55 P11678 PERE_HUMAN 51.138 0.860595 0.752448 EPX - Eosinophil peroxidase precursor - Homo sapiens (Human) - EPX gene Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. Taurus_UMD|evm.model.AC_000176.1.56 Q9NXB0 MKS1_HUMAN 91.234 0.996422 1 MKS1 - Meckel syndrome type 1 protein - Homo sapiens (Human) - MKS1 gene Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. Taurus_UMD|evm.model.AC_000176.1.57 P80025 PERL_BOVIN 100.000 0.997195 1.0014 LPO - Lactoperoxidase precursor - Bos taurus (Bovine) - LPO gene Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae. Taurus_UMD|evm.model.AC_000176.1.58 P05164 PERM_HUMAN 86.429 0.970833 0.966443 MPO - Myeloperoxidase precursor - Homo sapiens (Human) - MPO gene Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Taurus_UMD|evm.model.AC_000176.1.60 O95153 RIMB1_HUMAN 83.769 0.652761 0.87776 TSPOAP1 - Peripheral-type benzodiazepine receptor-associated protein 1 - Homo sapiens (Human) - TSPOAP1 gene cytoplasm, cytosol, mitochondrion, benzodiazepine receptor binding, C21-steroid hormone biosynthetic process, neurotransmitter transport Taurus_UMD|evm.model.AC_000176.1.61 Q4R941 SPT4H_MACFA 100.000 0.983051 1.00855 SUPT4H1 - Transcription elongation factor SPT4 - Macaca fascicularis (Crab-eating macaque) - SUPT4H1 gene Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity). Taurus_UMD|evm.model.AC_000176.1.62 Q68DV7 RNF43_HUMAN 86.207 0.997449 1.00128 RNF43 - E3 ubiquitin-protein ligase RNF43 precursor - Homo sapiens (Human) - RNF43 gene E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:18313049, PubMed:22575959, PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity). Taurus_UMD|evm.model.AC_000176.1.63 Q5ND04 HSF5_MOUSE 89.552 0.345286 2.77083 Hsf5 - Heat shock factor protein 5 - Mus musculus (Mouse) - Hsf5 gene May act as a transcriptional factor. Taurus_UMD|evm.model.AC_000176.1.64 P28661 SEPT4_MOUSE 93.231 0.471562 2.02301 Septin4 - Septin-4 - Mus musculus (Mouse) - Septin4 gene Filament-forming cytoskeletal GTPase (By similarity). Plays an important role in male fertility and sperm motility (PubMed:15737930, PubMed:15737931). During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (PubMed:15737930, PubMed:15737931). Taurus_UMD|evm.model.AC_000176.1.65 F1MJR8 TEX14_BOVIN 97.074 0.9987 1.03081 TEX14 - Inactive serine/threonine-protein kinase TEX14 - Bos taurus (Bovine) - TEX14 gene Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity). Taurus_UMD|evm.model.AC_000176.1.66 Q5RD86 DDA1_PONAB 74.227 0.914286 1.02941 DDA1 - DET1- and DDB1-associated protein 1 - Pongo abelii (Sumatran orangutan) - DDA1 gene Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex. Taurus_UMD|evm.model.AC_000176.1.67 O43502 RA51C_HUMAN 89.946 0.830317 1.17553 RAD51C - DNA repair protein RAD51 homolog 3 - Homo sapiens (Human) - RAD51C gene Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis. Taurus_UMD|evm.model.AC_000176.1.69 Q8WY54 PPM1E_HUMAN 91.103 0.8976 0.827815 PPM1E - Protein phosphatase 1E - Homo sapiens (Human) - PPM1E gene Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity). Taurus_UMD|evm.model.AC_000176.1.70 O94972 TRI37_HUMAN 93.368 0.997921 0.997925 TRIM37 - E3 ubiquitin-protein ligase TRIM37 - Homo sapiens (Human) - TRIM37 gene E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724). Taurus_UMD|evm.model.AC_000176.1.71 Q2TBY0 SKA2_BOVIN 99.174 0.983607 1.00826 SKA2 - Spindle and kinetochore-associated protein 2 - Bos taurus (Bovine) - SKA2 gene Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. Taurus_UMD|evm.model.AC_000176.1.72 Q96HE9 PRR11_HUMAN 78.363 0.837838 1.13056 PRR11 - Proline-rich protein 11 - Homo sapiens (Human) - PRR11 gene Plays a critical role in cell cycle progression. Taurus_UMD|evm.model.AC_000176.1.73 A1A4J7 SMG8_BOVIN 99.900 0.998 1.001 SMG8 - Protein SMG8 - Bos taurus (Bovine) - SMG8 gene Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity (By similarity). Taurus_UMD|evm.model.AC_000176.1.74 Q8N9F7 GDPD1_HUMAN 94.553 0.988417 0.824841 GDPD1 - Lysophospholipase D GDPD1 - Homo sapiens (Human) - GDPD1 gene Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:27637550, PubMed:25596343). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC) (PubMed:27637550, PubMed:25596343). May be involved in bioactive N-acylethanolamine biosynthesis from both N-acyl-lysoplasmenylethanolamin (N-acyl-lysoPlsEt) and N-acyl-lysophosphatidylethanolamin (N-acyl-lysoPE) (PubMed:27637550, PubMed:25596343). In addition, hydrolyzes glycerophospho-N-acylethanolamine to N-acylethanolamine (PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine (By similarity). Taurus_UMD|evm.model.AC_000176.1.76 Q5RDN9 YPEL2_PONAB 100.000 0.983333 1.0084 YPEL2 - Protein yippee-like 2 - Pongo abelii (Sumatran orangutan) - YPEL2 gene Taurus_UMD|evm.model.AC_000176.1.77 Q0VCP1 KAD4_BOVIN 97.758 0.991071 1.00448 AK4 - Adenylate kinase 4, mitochondrial - Bos taurus (Bovine) - AK4 gene Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). Also displays broad nucleoside diphosphate kinase activity (By similarity). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity). Plays a protective role in the cellular response to oxidative stress (By similarity). Taurus_UMD|evm.model.AC_000176.1.78 Q5R864 DHX40_PONAB 98.588 0.997436 1.00128 DHX40 - Probable ATP-dependent RNA helicase DHX40 - Pongo abelii (Sumatran orangutan) - DHX40 gene Probable ATP-dependent RNA helicase. Taurus_UMD|evm.model.AC_000176.1.79 P49951 CLH1_BOVIN 97.552 0.998777 0.976119 CLTC - Clathrin heavy chain 1 - Bos taurus (Bovine) - CLTC gene Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. Taurus_UMD|evm.model.AC_000176.1.80 Q3ZBL5 PTH2_BOVIN 100.000 0.847619 1.17318 PTRH2 - Peptidyl-tRNA hydrolase 2, mitochondrial precursor - Bos taurus (Bovine) - PTRH2 gene The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Taurus_UMD|evm.model.AC_000176.1.81 Q0VCK9 VMP1_BOVIN 100.000 0.995086 1.00246 VMP1 - Vacuole membrane protein 1 - Bos taurus (Bovine) - VMP1 gene Multispanning membrane protein in the endoplasmic reticulum (ER) required for autophagosome formation. Controls the disassociation of autophagosomes from the ER through its interaction with BECN1 and ATP2A2. Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes. Required for lipoprotein secretion, involved in the release of lipoproteins from the ER membrane to the ER lumen. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions (By similarity). Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death. Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity). Taurus_UMD|evm.model.AC_000176.1.82 Q4R7T7 TBD_MACFA 90.508 0.995595 1.00221 TUBD1 - Tubulin delta chain - Macaca fascicularis (Crab-eating macaque) - TUBD1 gene Acts as a positive regulator of hedgehog signaling and regulates ciliary function. Taurus_UMD|evm.model.AC_000176.1.83 Q6TJY3 KS6B1_BOVIN 100.000 0.996198 0.998102 RPS6KB1 - Ribosomal protein S6 kinase beta-1 - Bos taurus (Bovine) - RPS6KB1 gene Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR. Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition. Taurus_UMD|evm.model.AC_000176.1.84 Q5M7Z0 RNFT1_HUMAN 89.196 0.994987 0.917241 RNFT1 - E3 ubiquitin-protein ligase RNFT1 - Homo sapiens (Human) - RNFT1 gene E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Taurus_UMD|evm.model.AC_000176.1.85 Q9UHV7 MED13_HUMAN 95.771 0.98264 1.0069 MED13 - Mediator of RNA polymerase II transcription subunit 13 - Homo sapiens (Human) - MED13 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Taurus_UMD|evm.model.AC_000176.1.86 Q9H0H0 INT2_HUMAN 97.012 0.998342 1.00166 INTS2 - Integrator complex subunit 2 - Homo sapiens (Human) - INTS2 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). Taurus_UMD|evm.model.AC_000176.1.87 Q9BX63 FANCJ_HUMAN 78.404 0.840823 1.05124 BRIP1 - Fanconi anemia group J protein - Homo sapiens (Human) - BRIP1 gene DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Taurus_UMD|evm.model.AC_000176.1.89 Q9JIX0 ENY2_MOUSE 66.154 0.981481 0.534653 Eny2 - Transcription and mRNA export factor ENY2 - Mus musculus (Mouse) - Eny2 gene Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Taurus_UMD|evm.model.AC_000176.1.90 Q861Q9 TBX4_CANLF 94.991 0.953688 1.05235 TBX4 - T-box transcription factor TBX4 - Canis lupus familiaris (Dog) - TBX4 gene Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs. Taurus_UMD|evm.model.AC_000176.1.92 Q863A2 TBX2_CANLF 95.372 0.888471 1.12079 TBX2 - T-box transcription factor TBX2 - Canis lupus familiaris (Dog) - TBX2 gene Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be Required for cardiac atrioventricular canal formation (By similarity). Taurus_UMD|evm.model.AC_000176.1.93 Q9H6U6 BCAS3_HUMAN 96.861 0.997802 0.980603 BCAS3 - BCAS3 microtubule associated cell migration factor - Homo sapiens (Human) - BCAS3 gene Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). Taurus_UMD|evm.model.AC_000176.1.94 O15297 PPM1D_HUMAN 89.963 0.499069 0.887603 PPM1D - Protein phosphatase 1D - Homo sapiens (Human) - PPM1D gene Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). Taurus_UMD|evm.model.AC_000176.1.95 Q92624 APBP2_HUMAN 98.803 0.88351 1.12991 APPBP2 - Amyloid protein-binding protein 2 - Homo sapiens (Human) - APPBP2 gene May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface. Taurus_UMD|evm.model.AC_000176.1.96 Q32KP7 CQ064_BOVIN 100.000 0.954918 1.04274 Uncharacterized protein C17orf64 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000176.1.97 P30050 RL12_HUMAN 98.182 0.987952 1.00606 RPL12 - 60S ribosomal protein L12 - Homo sapiens (Human) - RPL12 gene Binds directly to 26S ribosomal RNA. Taurus_UMD|evm.model.AC_000176.1.98 Q8NFA0 UBP32_HUMAN 98.519 0.914966 0.183292 USP32 - Ubiquitin carboxyl-terminal hydrolase 32 precursor - Homo sapiens (Human) - USP32 gene cytosol, Golgi apparatus, thiol-dependent deubiquitinase, protein deubiquitination Taurus_UMD|evm.model.AC_000176.1.99 Q8NFA0 UBP32_HUMAN 95.253 0.998419 0.788653 USP32 - Ubiquitin carboxyl-terminal hydrolase 32 precursor - Homo sapiens (Human) - USP32 gene cytosol, Golgi apparatus, thiol-dependent deubiquitinase, protein deubiquitination Taurus_UMD|evm.model.AC_000176.1.100 Q95323 CAH4_BOVIN 100.000 0.99361 1.00321 CA4 - Carbonic anhydrase 4 precursor - Bos taurus (Bovine) - CA4 gene Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity). Taurus_UMD|evm.model.AC_000176.1.101 Q2KIH1 ZNHI3_BOVIN 88.268 0.987421 0.888268 ZNHIT3 - Zinc finger HIT domain-containing protein 3 - Bos taurus (Bovine) - ZNHIT3 gene cytoplasm, nucleus, pre-snoRNP complex, box C/D snoRNP assembly, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), snoRNA localization Taurus_UMD|evm.model.AC_000176.1.102 Q96H55 MYO19_HUMAN 80.498 0.99789 0.97732 MYO19 - Unconventional myosin-XIX - Homo sapiens (Human) - MYO19 gene Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824). Taurus_UMD|evm.model.AC_000176.1.103 Q1LZA4 PIGW_BOVIN 99.602 0.996032 1.00199 PIGW - Phosphatidylinositol-glycan biosynthesis class W protein - Bos taurus (Bovine) - PIGW gene Required for the transport of GPI-anchored proteins to the plasma membrane. Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins. Taurus_UMD|evm.model.AC_000176.1.105 Q9H3C7 GGNB2_HUMAN 92.558 0.997294 1.06026 GGNBP2 - Gametogenetin-binding protein 2 - Homo sapiens (Human) - GGNBP2 gene May be involved in spermatogenesis. Taurus_UMD|evm.model.AC_000176.1.106 Q3ZBV9 DHR11_BOVIN 100.000 0.767372 1.29804 DHRS11 - Dehydrogenase/reductase SDR family member 11 precursor - Bos taurus (Bovine) - DHRS11 gene Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. Taurus_UMD|evm.model.AC_000176.1.107 Q99J25 MRM1_MOUSE 77.429 0.880886 1.12813 Mrm1 - rRNA methyltransferase 1, mitochondrial precursor - Mus musculus (Mouse) - Mrm1 gene S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Taurus_UMD|evm.model.AC_000176.1.109 Q58DW0 RL4_BOVIN 95.972 0.995272 1.00237 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Taurus_UMD|evm.model.AC_000176.1.111 Q5IS89 LHX1_SAIBB 99.754 0.995086 1.00246 LHX1 - LIM/homeobox protein Lhx1 - Saimiri boliviensis boliviensis (Bolivian squirrel monkey) - LHX1 gene Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). Taurus_UMD|evm.model.AC_000176.1.112 Q9NY61 AATF_HUMAN 86.772 0.994709 1.0125 AATF - Protein AATF - Homo sapiens (Human) - AATF gene May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. Taurus_UMD|evm.model.AC_000176.1.114 Q9TTS3 ACACA_BOVIN 99.744 0.999148 1.00043 ACACA - Acetyl-CoA carboxylase 1 - Bos taurus (Bovine) - ACACA gene Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. Taurus_UMD|evm.model.AC_000176.1.115 A6H7F9 CQ078_BOVIN 99.306 0.99308 1.01049 Uncharacterized protein C17orf78 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000176.1.116 Q3SZP8 TAD2A_BOVIN 100.000 0.995495 1.00226 TADA2A - Transcriptional adapter 2-alpha - Bos taurus (Bovine) - TADA2A gene Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. Taurus_UMD|evm.model.AC_000176.1.117 Q17QM8 DUS14_BOVIN 100.000 0.98995 1.00505 DUSP14 - Dual specificity protein phosphatase 14 - Bos taurus (Bovine) - DUSP14 gene Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases (By similarity). Taurus_UMD|evm.model.AC_000176.1.118 Q5SV85 SYNRG_MOUSE 92.899 0.121212 1.06126 Synrg - Synergin gamma - Mus musculus (Mouse) - Synrg gene Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (By similarity). May act by linking the adapter protein complex AP-1 to other proteins (By similarity). Component of clathrin-coated vesicles (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity). Taurus_UMD|evm.model.AC_000176.1.119 A5D7C1 DDX52_BOVIN 100.000 0.99665 1.00168 DDX52 - Probable ATP-dependent RNA helicase DDX52 - Bos taurus (Bovine) - DDX52 gene maturation of SSU-rRNA Taurus_UMD|evm.model.AC_000176.1.120 Q03365 HNF1B_PIG 83.005 0.996 0.894454 HNF1B - Hepatocyte nuclear factor 1-beta - Sus scrofa (Pig) - HNF1B gene Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the PFC element in the UPA gene. Taurus_UMD|evm.model.AC_000176.1.122 Q5R5R2 HEAT6_PONAB 87.214 0.998308 1.00085 HEATR6 - HEAT repeat-containing protein 6 - Pongo abelii (Sumatran orangutan) - HEATR6 gene Taurus_UMD|evm.model.AC_000176.1.123 P56928 ENA2_HORSE 71.429 0.0742358 9.95652 Antimicrobial peptide eNAP-2 - Equus caballus (Horse) Taurus_UMD|evm.model.AC_000176.1.124 Q8SQA6 CCL3_BOVIN 74.286 0.734043 1.01075 CCL3 - C-C motif chemokine 3 precursor - Bos taurus (Bovine) - CCL3 gene Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity). Taurus_UMD|evm.model.AC_000176.1.125 P00993 IBP_CARCR 56.863 0.454545 1 Chelonianin - Caretta caretta (Loggerhead sea turtle) Taurus_UMD|evm.model.AC_000176.1.126 P62810 WFD18_MOUSE 54.545 0.603175 1.7027 Wfdc18 - WAP four-disulfide core domain protein 18 precursor - Mus musculus (Mouse) - Wfdc18 gene Could have proteinase inhibiting capacity. Taurus_UMD|evm.model.AC_000176.1.128 Q17QA1 CCL4_BOVIN 100.000 0.978495 1.01087 CCL4 - C-C motif chemokine 4 precursor - Bos taurus (Bovine) - CCL4 gene Monokine with inflammatory and chemokinetic properties. Taurus_UMD|evm.model.AC_000176.1.129 Q7L099 RUFY3_HUMAN 98.374 0.740181 0.705757 RUFY3 - Protein RUFY3 - Homo sapiens (Human) - RUFY3 gene Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner (PubMed:25766321). Taurus_UMD|evm.model.AC_000176.1.130 Q8SQA6 CCL3_BOVIN 97.826 0.968085 1.01075 CCL3 - C-C motif chemokine 3 precursor - Bos taurus (Bovine) - CCL3 gene Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity). Taurus_UMD|evm.model.AC_000176.1.131 Q8SQA6 CCL3_BOVIN 78.571 0.734043 1.01075 CCL3 - C-C motif chemokine 3 precursor - Bos taurus (Bovine) - CCL3 gene Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity). Taurus_UMD|evm.model.AC_000176.1.132 Q68A92 CCL3_CANLF 51.685 0.944444 0.978261 CCL3 - C-C motif chemokine 3 precursor - Canis lupus familiaris (Dog) - CCL3 gene Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity). Taurus_UMD|evm.model.AC_000176.1.133 P82943 REG1_BOVIN 100.000 0.978495 1.01087 Regakine-1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000176.1.134 P16619 CL3L1_HUMAN 57.143 0.421769 1.58065 CCL3L1 - C-C motif chemokine 3-like 1 precursor - Homo sapiens (Human) - CCL3L1 gene Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Taurus_UMD|evm.model.AC_000176.1.135 Q16627 CCL14_HUMAN 64.894 0.978947 1.02151 CCL14 - C-C motif chemokine 14 precursor - Homo sapiens (Human) - CCL14 gene Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. Taurus_UMD|evm.model.AC_000176.1.136 O15467 CCL16_HUMAN 71.569 0.980198 0.841667 CCL16 - C-C motif chemokine 16 precursor - Homo sapiens (Human) - CCL16 gene Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. Taurus_UMD|evm.model.AC_000176.1.137 O97919 CCL5_BOVIN 100.000 0.978261 1.01099 CCL5 - C-C motif chemokine 5 precursor - Bos taurus (Bovine) - CCL5 gene Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Taurus_UMD|evm.model.AC_000176.1.138 Q4R744 HEAT9_MACFA 67.708 0.991087 0.984211 HEATR9 - Protein HEATR9 - Macaca fascicularis (Crab-eating macaque) - HEATR9 gene Taurus_UMD|evm.model.AC_000176.1.139 Q92804 RBP56_HUMAN 95.939 0.629213 1.05236 TAF15 - TATA-binding protein-associated factor 2N - Homo sapiens (Human) - TAF15 gene RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). Taurus_UMD|evm.model.AC_000176.1.140 Q9H239 MMP28_HUMAN 71.702 0.77057 1.21538 MMP28 - Matrix metalloproteinase-28 precursor - Homo sapiens (Human) - MMP28 gene Can degrade casein. Could play a role in tissues homeostasis and repair. Taurus_UMD|evm.model.AC_000176.1.141 Q8WW18 CQ050_HUMAN 73.684 0.944444 1.03448 C17orf50 - Uncharacterized protein C17orf50 - Homo sapiens (Human) - C17orf50 gene Taurus_UMD|evm.model.AC_000176.1.142 Q8NHY3 GA2L2_HUMAN 72.727 0.997717 0.995455 GAS2L2 - GAS2-like protein 2 - Homo sapiens (Human) - GAS2L2 gene Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (By similarity). Regulates ciliary orientation and performance in cells located in the airway (PubMed:30665704). Taurus_UMD|evm.model.AC_000176.1.143 Q96S79 RSLAB_HUMAN 99.507 0.990196 1.00493 RASL10B - Ras-like protein family member 10B precursor - Homo sapiens (Human) - RASL10B gene May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure. Taurus_UMD|evm.model.AC_000176.1.144 Q08DS7 AP1B1_BOVIN 99.718 0.967213 0.384858 AP2B1 - AP-1 complex subunit beta-1 - Bos taurus (Bovine) - AP2B1 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity). Taurus_UMD|evm.model.AC_000176.1.145 P63009 AP2B1_BOVIN 100.000 0.995 0.640342 AP2B1 - AP-2 complex subunit beta - Bos taurus (Bovine) - AP2B1 gene Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly (By similarity). Taurus_UMD|evm.model.AC_000176.1.146 A4FUD4 PEX12_BOVIN 100.000 0.994444 1.00279 PEX12 - Peroxisome assembly protein 12 - Bos taurus (Bovine) - PEX12 gene Required for protein import into peroxisomes. Taurus_UMD|evm.model.AC_000176.1.147 P0C7P3 SLN14_HUMAN 76.586 0.997775 0.985746 SLFN14 - Protein SLFN14 - Homo sapiens (Human) - SLFN14 gene Shows no ribosome-associated and endoribonuclease activities. Taurus_UMD|evm.model.AC_000176.1.148 Q7Z7L1 SLN11_HUMAN 68.076 0.992205 0.99667 SLFN11 - Schlafen family member 11 - Homo sapiens (Human) - SLFN11 gene Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Acts independently of ATR (PubMed:29395061). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation (PubMed:23000900). Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA (PubMed:23000900). Taurus_UMD|evm.model.AC_000176.1.149 Q8IYM2 SLN12_HUMAN 61.939 0.954545 0.989619 SLFN12 - Schlafen family member 12 - Homo sapiens (Human) - SLFN12 gene Taurus_UMD|evm.model.AC_000176.1.151 Q8IWX7 UN45B_HUMAN 93.878 0.997849 0.998926 UNC45B - Protein unc-45 homolog B - Homo sapiens (Human) - UNC45B gene Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development. Taurus_UMD|evm.model.AC_000176.1.152 Q58D20 NLE1_BOVIN 100.000 0.995893 1.00206 NLE1 - Notchless protein homolog 1 - Bos taurus (Bovine) - NLE1 gene Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity). Taurus_UMD|evm.model.AC_000176.1.153 Q2YDH8 FNDC8_BOVIN 99.688 0.993789 1.00312 FNDC8 - Fibronectin type III domain-containing protein 8 - Bos taurus (Bovine) - FNDC8 gene Taurus_UMD|evm.model.AC_000176.1.154 Q2HJ51 RA51D_BOVIN 100.000 0.993884 1.00307 RAD51D - DNA repair protein RAD51 homolog 4 - Bos taurus (Bovine) - RAD51D gene Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM (By similarity). Taurus_UMD|evm.model.AC_000176.1.155 Q8WZ73 RFFL_HUMAN 87.052 0.96206 1.01653 RFFL - E3 ubiquitin-protein ligase rififylin - Homo sapiens (Human) - RFFL gene E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. Taurus_UMD|evm.model.AC_000176.1.156 P49916 DNLI3_HUMAN 87.697 0.998006 0.994054 LIG3 - DNA ligase 3 precursor - Homo sapiens (Human) - LIG3 gene Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). Taurus_UMD|evm.model.AC_000176.1.157 Q96NB3 ZN830_HUMAN 86.327 0.994652 1.00538 ZNF830 - Zinc finger protein 830 - Homo sapiens (Human) - ZNF830 gene May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity). Taurus_UMD|evm.model.AC_000176.1.158 Q3T084 TCPW_BOVIN 99.435 0.996241 1.00188 CCT6B - T-complex protein 1 subunit zeta-2 - Bos taurus (Bovine) - CCT6B gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. Taurus_UMD|evm.model.AC_000176.1.159 Q6IEE7 T132E_HUMAN 95.407 0.985822 0.985102 TMEM132E - Transmembrane protein 132E precursor - Homo sapiens (Human) - TMEM132E gene Required for normal inner ear hair cell function and hearing. Taurus_UMD|evm.model.AC_000176.1.161 P22362 CCL1_HUMAN 57.812 0.677419 0.96875 CCL1 - C-C motif chemokine 1 precursor - Homo sapiens (Human) - CCL1 gene Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. Taurus_UMD|evm.model.AC_000176.1.162 Q09141 CCL8_BOVIN 100.000 0.98 1.0101 CCL8 - C-C motif chemokine 8 precursor - Bos taurus (Bovine) - CCL8 gene Chemotactic factor that attracts monocytes. This protein can bind heparin. Taurus_UMD|evm.model.AC_000176.1.163 Q9TTS6 CCL11_BOVIN 100.000 0.979592 1.01031 CCL11 - Eotaxin precursor - Bos taurus (Bovine) - CCL11 gene In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils (Probable). Attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary (PubMed:15916812). Binds to CCR3 (By similarity). Taurus_UMD|evm.model.AC_000176.1.164 P28291 CCL2_BOVIN 100.000 0.98 1.0101 CCL2 - C-C motif chemokine 2 precursor - Bos taurus (Bovine) - CCL2 gene Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Taurus_UMD|evm.model.AC_000176.1.165 Q925H0 ASIC2_MOUSE 95.812 0.848214 0.4375 Asic2 - Acid-sensing ion channel 2 - Mus musculus (Mouse) - Asic2 gene Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Taurus_UMD|evm.model.AC_000176.1.168 P78348 ASIC1_HUMAN 39.548 0.661538 0.492424 ASIC1 - Acid-sensing ion channel 1 - Homo sapiens (Human) - ASIC1 gene Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. Taurus_UMD|evm.model.AC_000176.1.169 Q925H0 ASIC2_MOUSE 93.939 0.961538 0.660156 Asic2 - Acid-sensing ion channel 2 - Mus musculus (Mouse) - Asic2 gene Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Taurus_UMD|evm.model.AC_000176.1.170 A6QQ77 SACA3_BOVIN 100.000 0.607362 1 SPACA3 - Sperm acrosome membrane-associated protein 3 precursor - Bos taurus (Bovine) - SPACA3 gene Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro (By similarity). Taurus_UMD|evm.model.AC_000176.1.171 Q2HJB9 TMM98_BOVIN 99.558 0.806452 1.23451 TMEM98 - Transmembrane protein 98 - Bos taurus (Bovine) - TMEM98 gene Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). Taurus_UMD|evm.model.AC_000176.1.172 Q17R14 MYO1D_BOVIN 99.859 0.798643 0.878728 MYO1D - Unconventional myosin-Id - Bos taurus (Bovine) - MYO1D gene Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity). Taurus_UMD|evm.model.AC_000176.1.173 Q28199 CD5R1_BOVIN 100.000 0.993506 1.00326 CDK5R1 - Cyclin-dependent kinase 5 activator 1 precursor - Bos taurus (Bovine) - CDK5R1 gene p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution (By similarity). Taurus_UMD|evm.model.AC_000176.1.174 F1LMZ8 PSD11_RAT 96.998 0.995392 1.02844 Psmd11 - 26S proteasome non-ATPase regulatory subunit 11 - Rattus norvegicus (Rat) - Psmd11 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Taurus_UMD|evm.model.AC_000176.1.175 Q5R8K4 ZN207_PONAB 98.785 0.99596 1.00202 ZNF207 - BUB3-interacting and GLEBS motif-containing protein ZNF207 - Pongo abelii (Sumatran orangutan) - ZNF207 gene Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome. Taurus_UMD|evm.model.AC_000176.1.176 Q9HAS0 NJMU_HUMAN 88.957 0.878378 0.934343 C17orf75 - Protein Njmu-R1 - Homo sapiens (Human) - C17orf75 gene As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). May have a role in spermatogenesis. Taurus_UMD|evm.model.AC_000176.1.177 P58872 RHBL3_HUMAN 97.493 0.975477 0.908416 RHBDL3 - Rhomboid-related protein 3 - Homo sapiens (Human) - RHBDL3 gene May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Taurus_UMD|evm.model.AC_000176.1.178 Q2HJF8 MIRO1_BOVIN 93.750 0.997028 1.06656 RHOT1 - Mitochondrial Rho GTPase 1 - Bos taurus (Bovine) - RHOT1 gene Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). Taurus_UMD|evm.model.AC_000176.1.179 Q8IUD6 RN135_HUMAN 65.057 0.995294 0.983796 RNF135 - E3 ubiquitin-protein ligase RNF135 - Homo sapiens (Human) - RNF135 gene E2-dependent E3 ubiquitin-protein ligase that functions as a RIG-I/DDX58 coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response (PubMed:19017631, PubMed:19484123, PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531). Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway (PubMed:19017631, PubMed:21147464, PubMed:28469175, PubMed:31006531). Through a ubiquitin-independent parallel mechanism, which consists in bridging RIG-I/DDX58 filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway (PubMed:31006531). This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (Probable). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway (PubMed:28469175, PubMed:31006531). Taurus_UMD|evm.model.AC_000176.1.180 Q9NPF8 ADAP2_HUMAN 86.614 0.994667 0.984252 ADAP2 - Arf-GAP with dual PH domain-containing protein 2 - Homo sapiens (Human) - ADAP2 gene GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. Taurus_UMD|evm.model.AC_000176.1.181 A6QPR9 TEFM_BOVIN 99.719 0.98338 1.01404 TEFM - Transcription elongation factor, mitochondrial precursor - Bos taurus (Bovine) - TEFM gene Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery (By similarity). Taurus_UMD|evm.model.AC_000176.1.182 Q96QE3 ATAD5_HUMAN 74.974 0.998944 1.02711 ATAD5 - ATPase family AAA domain-containing protein 5 - Homo sapiens (Human) - ATAD5 gene Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis. Taurus_UMD|evm.model.AC_000176.1.183 Q8IUI8 CRLF3_HUMAN 95.785 0.968182 0.995475 CRLF3 - Cytokine receptor-like factor 3 - Homo sapiens (Human) - CRLF3 gene May play a role in the negative regulation of cell cycle progression. Taurus_UMD|evm.model.AC_000176.1.184 Q15022 SUZ12_HUMAN 99.188 0.997297 1.00135 SUZ12 - Polycomb protein SUZ12 - Homo sapiens (Human) - SUZ12 gene Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). Taurus_UMD|evm.model.AC_000176.1.185 Q8VCY6 UTP6_MOUSE 75.168 0.993322 1.00335 Utp6 - U3 small nucleolar RNA-associated protein 6 homolog - Mus musculus (Mouse) - Utp6 gene Involved in nucleolar processing of pre-18S ribosomal RNA. Taurus_UMD|evm.model.AC_000176.1.186 A5PJD3 COPRS_BOVIN 100.000 0.867816 0.940541 COPRS - Coordinator of PRMT5 and differentiation stimulator - Bos taurus (Bovine) - COPRS gene Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression (By similarity). Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity). Taurus_UMD|evm.model.AC_000176.1.188 Q86YS3 RFIP4_HUMAN 94.692 0.925397 0.989011 RAB11FIP4 - Rab11 family-interacting protein 4 - Homo sapiens (Human) - RAB11FIP4 gene Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. Taurus_UMD|evm.model.AC_000176.1.189 P21359 NF1_HUMAN 99.261 0.41219 0.924621 NF1 - Neurofibromin - Homo sapiens (Human) - NF1 gene Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. Taurus_UMD|evm.model.AC_000176.1.190 Q9Y6I7 WSB1_HUMAN 97.862 0.995261 1.00238 WSB1 - WD repeat and SOCS box-containing protein 1 - Homo sapiens (Human) - WSB1 gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation. Taurus_UMD|evm.model.AC_000176.1.191 Q8IVT5 KSR1_HUMAN 90.033 0.997748 0.96208 KSR1 - Kinase suppressor of Ras 1 - Homo sapiens (Human) - KSR1 gene Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). Taurus_UMD|evm.model.AC_000176.1.192 P97840 LEG9_RAT 64.430 0.845714 0.49435 Lgals9 - Galectin-9 - Rattus norvegicus (Rat) - Lgals9 gene Binds galactosides (By similarity). Has high affinity for the Forssman pentasaccharide (By similarity). Ligand for HAVCR2/TIM3 (By similarity). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (By similarity). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (By similarity). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (By similarity). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (By similarity). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (By similarity). Inhibits degranulation and induces apoptosis of mast cells (By similarity). Induces maturation and migration of dendritic cells (By similarity). Inhibits natural killer (NK) cell function (By similarity). Can transform NK cell phenotype from peripheral to decidual during pregnancy (By similarity). Astrocyte derived galectin-9 enhances microglial TNF production (PubMed:25158758). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (PubMed:8995305). Highly selective to the anion urate (PubMed:8995305). Taurus_UMD|evm.model.AC_000176.1.193 O00182 LEG9_HUMAN 67.273 0.433735 0.701408 LGALS9 - Galectin-9 - Homo sapiens (Human) - LGALS9 gene Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (PubMed:20209097). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (PubMed:24465902, PubMed:16116184). Inhibits degranulation and induces apoptosis of mast cells (PubMed:24465902). Induces maturation and migration of dendritic cells (PubMed:25754930, PubMed:16116184). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (PubMed:25578313). Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity). Taurus_UMD|evm.model.AC_000176.1.194 Q3MHZ8 LEG9_BOVIN 99.718 0.994382 1.00282 LGALS9 - Galectin-9 - Bos taurus (Bovine) - LGALS9 gene Binds galactosides. Has high affinity for the Forssman pentasaccharide. Ligand for HAVCR2/TIM3. Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death. Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth. Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function. Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation. Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection. Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells. Inhibits degranulation and induces apoptosis of mast cells. Induces maturation and migration of dendritic cells. Inhibits natural killer (NK) cell function. Can transform NK cell phenotype from peripheral to decidual during pregnancy. Astrocyte derived galectin-9 enhances microglial TNF production. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion. Highly selective to the anion urate. Taurus_UMD|evm.model.AC_000176.1.195 Q27995 NOS2_BOVIN 99.732 0.968858 1 NOS2 - Nitric oxide synthase, inducible - Bos taurus (Bovine) - NOS2 gene Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8. Taurus_UMD|evm.model.AC_000176.1.197 Q9BZM4 ULBP3_HUMAN 41.152 0.967611 1.0123 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000176.1.198 Q9BZM4 ULBP3_HUMAN 48.515 0.813008 0.504098 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000176.1.199 Q9BZM4 ULBP3_HUMAN 48.187 0.842593 0.885246 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000176.1.200 Q9BZM4 ULBP3_HUMAN 49.065 0.864198 0.995902 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000176.1.201 Q5VY80 ULBP6_HUMAN 47.541 0.719368 1.02846 RAET1L - UL16-binding protein 6 precursor - Homo sapiens (Human) - RAET1L gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000176.1.203 A5D7J1 LYRM9_BOVIN 100.000 0.808989 1.14103 LYRM9 - LYR motif-containing protein 9 - Bos taurus (Bovine) - LYRM9 gene Taurus_UMD|evm.model.AC_000176.1.204 Q98TF8 RL22_CHICK 82.759 0.924731 0.726562 RPL22 - 60S ribosomal protein L22 - Gallus gallus (Chicken) - RPL22 gene RNA binding, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000176.1.205 Q9UBE8 NLK_HUMAN 100.000 0.996212 1.0019 NLK - Serine/threonine-protein kinase NLK - Homo sapiens (Human) - NLK gene Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613). Taurus_UMD|evm.model.AC_000176.1.207 Q3MHW7 SGMR2_BOVIN 100.000 0.988701 1.00568 TMEM97 - Sigma intracellular receptor 2 - Bos taurus (Bovine) - TMEM97 gene Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. Taurus_UMD|evm.model.AC_000176.1.208 Q58CS6 IFT20_BOVIN 100.000 0.987261 1.00641 IFT20 - Intraflagellar transport protein 20 homolog - Bos taurus (Bovine) - IFT20 gene Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling. Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. Taurus_UMD|evm.model.AC_000176.1.209 Q13829 BACD2_HUMAN 98.101 0.993691 1.00316 TNFAIP1 - BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 - Homo sapiens (Human) - TNFAIP1 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. Taurus_UMD|evm.model.AC_000176.1.210 Q9Y2S7 PDIP2_HUMAN 97.283 0.99458 1.00272 POLDIP2 - Polymerase delta-interacting protein 2 precursor - Homo sapiens (Human) - POLDIP2 gene Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites (PubMed:24191025). May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1) (PubMed:24191025, PubMed:26984527). Taurus_UMD|evm.model.AC_000176.1.211 Q8N511 TM199_HUMAN 92.788 0.990291 0.990385 TMEM199 - Transmembrane protein 199 - Homo sapiens (Human) - TMEM199 gene Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833330). Taurus_UMD|evm.model.AC_000176.1.212 Q9HB31 SEBOX_HUMAN 71.579 0.989529 1.00526 SEBOX - Homeobox protein SEBOX - Homo sapiens (Human) - SEBOX gene Probable transcription factor involved in the control of specification of mesoderm and endoderm. Taurus_UMD|evm.model.AC_000176.1.213 P04004 VTNC_HUMAN 71.367 0.953878 0.997908 VTN - Vitronectin precursor - Homo sapiens (Human) - VTN gene Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Taurus_UMD|evm.model.AC_000176.1.214 Q6SZW1 SARM1_HUMAN 93.914 0.990398 1.00691 SARM1 - NAD(+) hydrolase SARM1 precursor - Homo sapiens (Human) - SARM1 gene NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439793, PubMed:32049506, PubMed:32828421, PubMed:31439792, PubMed:33053563). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). Can activate neuronal cell death in response to stress (PubMed:20306472). Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity). Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262). Taurus_UMD|evm.model.AC_000176.1.215 Q05B81 PCFT_BOVIN 100.000 0.995652 1.00218 SLC46A1 - Proton-coupled folate transporter - Bos taurus (Bovine) - SLC46A1 gene Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. Taurus_UMD|evm.model.AC_000176.1.216 A8D8X1 RL10_SHEEP 76.712 0.972973 0.345794 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000176.1.217 Q9ES88 S13A2_MOUSE 77.414 0.971332 1.01195 Slc13a2 - Solute carrier family 13 member 2 - Mus musculus (Mouse) - Slc13a2 gene Cotransport of sodium ions and dicarboxylates such as succinate and citrate. Taurus_UMD|evm.model.AC_000176.1.218 O15353 FOXN1_HUMAN 90.139 0.996904 0.996914 FOXN1 - Forkhead box protein N1 - Homo sapiens (Human) - FOXN1 gene Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891). Taurus_UMD|evm.model.AC_000176.1.219 Q3SYR2 U119A_BOVIN 100.000 0.991701 1.00417 UNC119 - Protein unc-119 homolog A - Bos taurus (Bovine) - UNC119 gene Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A (By similarity). Taurus_UMD|evm.model.AC_000176.1.220 Q3SZL5 PIGS_BOVIN 99.820 0.996403 1.0018 PIGS - GPI transamidase component PIG-S - Bos taurus (Bovine) - PIGS gene Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates (By similarity). Taurus_UMD|evm.model.AC_000176.1.221 Q9GKW3 ALDOC_MACFA 98.901 0.710372 1.40385 ALDOC - Fructose-bisphosphate aldolase C - Macaca fascicularis (Crab-eating macaque) - ALDOC gene fructose-bisphosphate aldolase activity, fructose 1,6-bisphosphate metabolic process Taurus_UMD|evm.model.AC_000176.1.222 Q96R06 SPAG5_HUMAN 78.010 0.998325 1.00084 SPAG5 - Sperm-associated antigen 5 - Homo sapiens (Human) - SPAG5 gene Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). Taurus_UMD|evm.model.AC_000176.1.223 Q96LW2 KS6R_HUMAN 85.784 0.987685 0.990244 RSKR - Ribosomal protein S6 kinase-related protein - Homo sapiens (Human) - RSKR gene Taurus_UMD|evm.model.AC_000176.1.224 Q14667 K0100_HUMAN 94.078 0.989247 0.998658 KIAA0100 - Protein KIAA0100 precursor - Homo sapiens (Human) - KIAA0100 gene May be involved in membrane trafficking. Taurus_UMD|evm.model.AC_000176.1.225 Q3SZ45 SDF2_BOVIN 100.000 0.990566 1.00474 SDF2 - Stromal cell-derived factor 2 precursor - Bos taurus (Bovine) - SDF2 gene Taurus_UMD|evm.model.AC_000176.1.226 Q7KZ85 SPT6H_HUMAN 98.957 0.998842 1.00058 SUPT6H - Transcription elongation factor SPT6 - Homo sapiens (Human) - SUPT6H gene Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. Taurus_UMD|evm.model.AC_000176.1.227 A7E371 PRCA1_BOVIN 100.000 0.994695 1.00266 PROCA1 - Protein PROCA1 - Bos taurus (Bovine) - PROCA1 gene Taurus_UMD|evm.model.AC_000176.1.228 Q9BZG1 RAB34_HUMAN 75.290 0.990476 0.810811 RAB34 - Ras-related protein Rab-34 - Homo sapiens (Human) - RAB34 gene Transport protein involved in the redistribution of lysosomes to the peri-Golgi region (PubMed:27113757). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity). Taurus_UMD|evm.model.AC_000176.1.229 P62752 RL23A_RAT 100.000 0.987261 1.00641 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000176.1.230 Q96CP7 TLCD1_HUMAN 89.316 0.939516 1.00405 TLCD1 - TLC domain-containing protein 1 precursor - Homo sapiens (Human) - TLCD1 gene Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349). Taurus_UMD|evm.model.AC_000176.1.231 Q86SG6 NEK8_HUMAN 93.840 0.983075 1.02457 NEK8 - Serine/threonine-protein kinase Nek8 - Homo sapiens (Human) - NEK8 gene Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. Taurus_UMD|evm.model.AC_000176.1.232 Q9BUZ4 TRAF4_HUMAN 97.872 0.995754 1.00213 TRAF4 - TNF receptor-associated factor 4 - Homo sapiens (Human) - TRAF4 gene Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Taurus_UMD|evm.model.AC_000176.1.233 Q8WU58 F222B_HUMAN 95.915 0.996454 1.00356 FAM222B - Protein FAM222B - Homo sapiens (Human) - FAM222B gene nucleoplasm Taurus_UMD|evm.model.AC_000176.1.234 A5PK43 ERAL1_BOVIN 100.000 0.995434 1.00229 ERAL1 - GTPase Era, mitochondrial precursor - Bos taurus (Bovine) - ERAL1 gene Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity). Taurus_UMD|evm.model.AC_000176.1.235 A6QLR4 FLOT2_BOVIN 100.000 0.994737 0.88785 FLOT2 - Flotillin-2 - Bos taurus (Bovine) - FLOT2 gene May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function (By similarity). Taurus_UMD|evm.model.AC_000176.1.236 Q17QU7 DHR13_BOVIN 100.000 0.994709 1.00265 DHRS13 - Dehydrogenase/reductase SDR family member 13 precursor - Bos taurus (Bovine) - DHRS13 gene Putative oxidoreductase. Taurus_UMD|evm.model.AC_000176.1.237 Q96QT6 PHF12_HUMAN 97.211 0.99801 1.001 PHF12 - PHD finger protein 12 - Homo sapiens (Human) - PHF12 gene Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA. Taurus_UMD|evm.model.AC_000176.1.238 A0JNA2 SEZ6_BOVIN 99.897 0.98881 1 SEZ6 - Seizure protein 6 homolog precursor - Bos taurus (Bovine) - SEZ6 gene May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity). Taurus_UMD|evm.model.AC_000176.1.239 Q29RU9 SOX_BOVIN 100.000 0.994911 1.00255 PIPOX - Peroxisomal sarcosine oxidase - Bos taurus (Bovine) - PIPOX gene Metabolizes sarcosine, L-pipecolic acid and L-proline. Taurus_UMD|evm.model.AC_000176.1.240 Q92614 MY18A_HUMAN 97.140 0.435566 1.05404 MYO18A - Unconventional myosin-XVIIIa - Homo sapiens (Human) - MYO18A gene May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). Taurus_UMD|evm.model.AC_000176.1.241 P11843 CRBA1_BOVIN 99.535 0.990741 1.00465 CRYBA1 - Beta-crystallin A3 - Bos taurus (Bovine) - CRYBA1 gene Crystallins are the dominant structural components of the vertebrate eye lens. Taurus_UMD|evm.model.AC_000176.1.242 Q7Z417 NUFP2_HUMAN 95.455 0.944126 1.00432 NUFIP2 - Nuclear fragile X mental retardation-interacting protein 2 - Homo sapiens (Human) - NUFIP2 gene Binds RNA. Taurus_UMD|evm.model.AC_000176.1.243 Q7L7X3 TAOK1_HUMAN 99.700 0.998004 1.001 TAOK1 - Serine/threonine-protein kinase TAO1 - Homo sapiens (Human) - TAOK1 gene Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Taurus_UMD|evm.model.AC_000176.1.244 Q6UXT9 ABH15_HUMAN 89.744 0.995736 1.00214 ABHD15 - Protein ABHD15 precursor - Homo sapiens (Human) - ABHD15 gene membrane, acylglycerol lipase activity, short-chain carboxylesterase activity, cellular lipid metabolic process Taurus_UMD|evm.model.AC_000176.1.245 Q8NBR0 P5I13_HUMAN 76.533 0.944444 1.00763 TP53I13 - Tumor protein p53-inducible protein 13 precursor - Homo sapiens (Human) - TP53I13 gene May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed. Taurus_UMD|evm.model.AC_000176.1.246 Q9Y2X7 GIT1_HUMAN 98.387 0.971242 1.00526 GIT1 - ARF GTPase-activating protein GIT1 - Homo sapiens (Human) - GIT1 gene GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). Taurus_UMD|evm.model.AC_000176.1.247 Q86YJ7 AN13B_HUMAN 97.774 0.996825 1.00639 ANKRD13B - Ankyrin repeat domain-containing protein 13B - Homo sapiens (Human) - ANKRD13B gene Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. Taurus_UMD|evm.model.AC_000176.1.248 Q920J3 CORO6_RAT 95.551 0.241397 4.125 Coro6 - Coronin-6 - Rattus norvegicus (Rat) - Coro6 gene actin filament binding, actin filament organization, cell migration Taurus_UMD|evm.model.AC_000176.1.249 A4FU69 EFCB5_HUMAN 69.302 0.998647 0.983367 EFCAB5 - EF-hand calcium-binding domain-containing protein 5 - Homo sapiens (Human) - EFCAB5 gene Taurus_UMD|evm.model.AC_000176.1.250 Q2KIC0 NSRP1_BOVIN 95.528 0.996276 0.960644 NSRP1 - Nuclear speckle splicing regulatory protein 1 - Bos taurus (Bovine) - NSRP1 gene RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Taurus_UMD|evm.model.AC_000176.1.251 Q9XT49 SC6A4_BOVIN 94.937 0.996727 0.969841 SLC6A4 - Sodium-dependent serotonin transporter - Bos taurus (Bovine) - SLC6A4 gene Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. Taurus_UMD|evm.model.AC_000176.1.252 P70645 BLMH_RAT 94.457 0.978261 1.01322 Blmh - Bleomycin hydrolase - Rattus norvegicus (Rat) - Blmh gene The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity). Binds single-stranded DNA with higher affinity than double-stranded DNA. May play an important role in the metabolism of antibiotics. Taurus_UMD|evm.model.AC_000176.1.253 Q3T113 TMIG1_BOVIN 99.617 0.992366 1.00383 TMIGD1 - Transmembrane and immunoglobulin domain-containing protein 1 precursor - Bos taurus (Bovine) - TMIGD1 gene May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival. Taurus_UMD|evm.model.AC_000176.1.254 Q2TBU3 GOSR1_BOVIN 100.000 0.188189 5.08 GOSR1 - Golgi SNAP receptor complex member 1 - Bos taurus (Bovine) - GOSR1 gene Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi (By similarity). Taurus_UMD|evm.model.AC_000176.1.255 Q2MHH0 TARG1_RAT 76.923 0.815789 1.09827 Trarg1 - Trafficking regulator of GLUT4 1 - Rattus norvegicus (Rat) - Trarg1 gene Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. Taurus_UMD|evm.model.AC_000176.1.256 Q7RTU4 BHA09_HUMAN 69.328 0.991111 0.957447 BHLHA9 - Class A basic helix-loop-helix protein 9 - Homo sapiens (Human) - BHLHA9 gene Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis. Taurus_UMD|evm.model.AC_000176.1.257 Q6PAJ1 BCR_MOUSE 46.154 0.16285 0.309449 Bcr - Breakpoint cluster region protein - Mus musculus (Mouse) - Bcr gene Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The amino terminus contains an intrinsic kinase activity (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (PubMed:20962234). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (By similarity). Taurus_UMD|evm.model.AC_000176.1.258 A6QNS3 ABR_BOVIN 100.000 0.997674 1.00116 ABR - Active breakpoint cluster region-related protein - Bos taurus (Bovine) - ABR gene Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). Taurus_UMD|evm.model.AC_000176.1.259 Q5BIN4 TIM22_BOVIN 100.000 0.989744 1.00515 TIMM22 - Mitochondrial import inner membrane translocase subunit Tim22 - Bos taurus (Bovine) - TIMM22 gene Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). Taurus_UMD|evm.model.AC_000176.1.260 A6QLU8 NXN_BOVIN 98.361 0.426056 0.652874 NXN - Nucleoredoxin - Bos taurus (Bovine) - NXN gene Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity). Taurus_UMD|evm.model.AC_000176.1.261 A6QLU8 NXN_BOVIN 100.000 0.646091 1.11724 NXN - Nucleoredoxin - Bos taurus (Bovine) - NXN gene Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity). Taurus_UMD|evm.model.AC_000176.1.262 Q9HC36 MRM3_HUMAN 84.915 0.987923 0.985714 MRM3 - rRNA methyltransferase 3, mitochondrial precursor - Homo sapiens (Human) - MRM3 gene S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Taurus_UMD|evm.model.AC_000176.1.263 Q9CPV4 GLOD4_MOUSE 79.866 0.993151 0.979866 Glod4 - Glyoxalase domain-containing protein 4 - Mus musculus (Mouse) - Glod4 gene mitochondrion Taurus_UMD|evm.model.AC_000176.1.264 Q9MZG3 DBIL5_BOVIN 100.000 0.747826 1.32184 DBIL5 - Diazepam-binding inhibitor-like 5 - Bos taurus (Bovine) - DBIL5 gene May be involved in the energy metabolism of the mature sperm. Taurus_UMD|evm.model.AC_000176.1.265 P57678 GEMI4_HUMAN 84.754 0.978664 1.0189 GEMIN4 - Gem-associated protein 4 - Homo sapiens (Human) - GEMIN4 gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Taurus_UMD|evm.model.AC_000176.1.266 Q8TBR7 TLC3A_HUMAN 80.620 0.992278 1.00778 TLCD3A - TLC domain-containing protein 3A - Homo sapiens (Human) - TLCD3A gene endoplasmic reticulum, plasma membrane, lipid homeostasis Taurus_UMD|evm.model.AC_000176.1.267 Q5R5J4 VPS53_PONAB 97.957 0.997599 1.0012 VPS53 - Vacuolar protein sorting-associated protein 53 homolog - Pongo abelii (Sumatran orangutan) - VPS53 gene Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Taurus_UMD|evm.model.AC_000176.1.269 Q8N5W9 RFLB_HUMAN 84.783 0.805882 0.794393 RFLNB - Refilin-B - Homo sapiens (Human) - RFLNB gene Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements. Taurus_UMD|evm.model.AC_000176.1.270 Q6ZQX7 LIAT1_HUMAN 64.151 0.825911 0.545254 LIAT1 - Protein LIAT1 - Homo sapiens (Human) - LIAT1 gene May be involved in ATE1-mediated N-terminal arginylation. Taurus_UMD|evm.model.AC_000176.1.271 Q58D79 RPH3L_BOVIN 97.251 0.436747 2.27397 RPH3AL - Rab effector Noc2 - Bos taurus (Bovine) - RPH3AL gene Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Taurus_UMD|evm.model.AC_000176.1.272 P62262 1433E_SHEEP 100.000 0.992188 1.00392 YWHAE - 14-3-3 protein epsilon - Ovis aries (Sheep) - YWHAE gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Taurus_UMD|evm.model.AC_000176.1.273 P46108 CRK_HUMAN 100.000 0.993443 1.00329 CRK - Adapter molecule crk - Homo sapiens (Human) - CRK gene Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. Taurus_UMD|evm.model.AC_000176.1.274 Q27966 MYO1C_BOVIN 100.000 0.99812 1.00094 MYO1C - Unconventional myosin-Ic - Bos taurus (Bovine) - MYO1C gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity). Taurus_UMD|evm.model.AC_000176.1.275 Q9BT40 INP5K_HUMAN 78.396 0.988889 1.00446 INPP5K - Inositol polyphosphate 5-phosphatase K - Homo sapiens (Human) - INPP5K gene Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PubMed:10753883, PubMed:16824732). Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (PubMed:10753883). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity). Taurus_UMD|evm.model.AC_000176.1.276 Q2HJ54 PIPNA_BOVIN 100.000 0.99262 1.0037 PITPNA - Phosphatidylinositol transfer protein alpha isoform - Bos taurus (Bovine) - PITPNA gene Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:7654206). Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (By similarity). Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (By similarity). Taurus_UMD|evm.model.AC_000176.1.277 Q0VCM6 LAT4_BOVIN 100.000 0.815827 1.22359 SLC43A2 - Large neutral amino acids transporter small subunit 4 - Bos taurus (Bovine) - SLC43A2 gene Sodium-, chloride, pH-independent high affinity transport of large neutral amino acids. Taurus_UMD|evm.model.AC_000176.1.278 Q14162 SREC_HUMAN 78.309 0.872454 1.1241 SCARF1 - Scavenger receptor class F member 1 precursor - Homo sapiens (Human) - SCARF1 gene Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). Taurus_UMD|evm.model.AC_000176.1.279 Q96NA2 RILP_HUMAN 78.571 0.959288 0.98005 RILP - Rab-interacting lysosomal protein - Homo sapiens (Human) - RILP gene Rab effector playing a role in late endocytic transport to degradative compartments (PubMed:11696325, PubMed:14668488, PubMed:27113757, PubMed:11179213, PubMed:12944476). Involved in the regulation of lysosomal morphology and distribution (PubMed:14668488, PubMed:27113757). Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments (PubMed:11179213, PubMed:11696325). Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes (PubMed:12944476). Taurus_UMD|evm.model.AC_000176.1.280 Q6P2Q9 PRP8_HUMAN 100.000 0.901506 1.10878 PRPF8 - Pre-mRNA-processing-splicing factor 8 - Homo sapiens (Human) - PRPF8 gene Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. Taurus_UMD|evm.model.AC_000176.1.281 Q562E7 WDR81_HUMAN 89.191 0.998974 1.00412 WDR81 - WD repeat-containing protein 81 - Homo sapiens (Human) - WDR81 gene Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity). Taurus_UMD|evm.model.AC_000176.1.282 P28800 A2AP_BOVIN 100.000 0.995943 1.00203 SERPINF2 - Alpha-2-antiplasmin precursor - Bos taurus (Bovine) - SERPINF2 gene Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin (By similarity). Taurus_UMD|evm.model.AC_000176.1.283 Q95121 PEDF_BOVIN 100.000 0.995204 1.0024 SERPINF1 - Pigment epithelium-derived factor precursor - Bos taurus (Bovine) - SERPINF1 gene Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Taurus_UMD|evm.model.AC_000176.1.284 Q95121 PEDF_BOVIN 100.000 0.828947 0.365385 SERPINF1 - Pigment epithelium-derived factor precursor - Bos taurus (Bovine) - SERPINF1 gene Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Taurus_UMD|evm.model.AC_000176.1.285 Q8IYR2 SMYD4_HUMAN 74.471 0.995019 0.998756 SMYD4 - SET and MYND domain-containing protein 4 - Homo sapiens (Human) - SMYD4 gene Taurus_UMD|evm.model.AC_000176.1.286 P27694 RFA1_HUMAN 90.097 0.996759 1.00162 RPA1 - Replication protein A 70 kDa DNA-binding subunit - Homo sapiens (Human) - RPA1 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:27723720, PubMed:27723717). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance (PubMed:17959650). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). Taurus_UMD|evm.model.AC_000176.1.287 Q8K0S5 R4RL1_MOUSE 90.583 0.995526 1.00449 Rtn4rl1 - Reticulon-4 receptor-like 1 precursor - Mus musculus (Mouse) - Rtn4rl1 gene Cell surface receptor that plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system (PubMed:22406547, PubMed:27339102). Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum (PubMed:27339102). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (PubMed:26335717). Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans (PubMed:22406547). Binds heparin (PubMed:22406547). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). Taurus_UMD|evm.model.AC_000176.1.288 Q3SYT1 DPH1_BOVIN 99.772 0.995444 1.00228 DPH1 - 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 - Bos taurus (Bovine) - DPH1 gene Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. Taurus_UMD|evm.model.AC_000176.1.289 Q3SZ07 OVCA2_BOVIN 100.000 0.833948 1.19383 OVCA2 - Esterase OVCA2 - Bos taurus (Bovine) - OVCA2 gene cytoplasm, nucleus, response to retinoic acid Taurus_UMD|evm.model.AC_000176.1.290 Q14526 HIC1_HUMAN 99.296 0.187251 1.02729 HIC1 - Hypermethylated in cancer 1 protein - Homo sapiens (Human) - HIC1 gene Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). Taurus_UMD|evm.model.AC_000176.1.291 Q5RAK6 EST1A_PONAB 92.755 0.98858 0.987315 SMG6 - Telomerase-binding protein EST1A - Pongo abelii (Sumatran orangutan) - SMG6 gene Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). Taurus_UMD|evm.model.AC_000176.1.292 A0JNI4 SRR_BOVIN 100.000 0.99403 1.00299 SRR - Serine racemase - Bos taurus (Bovine) - SRR gene Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity). Taurus_UMD|evm.model.AC_000176.1.293 Q2NL82 TSR1_HUMAN 89.950 0.997516 1.00124 TSR1 - Pre-rRNA-processing protein TSR1 homolog - Homo sapiens (Human) - TSR1 gene Required during maturation of the 40S ribosomal subunit in the nucleolus. Taurus_UMD|evm.model.AC_000176.1.294 O43147 SGSM2_HUMAN 87.167 0.998095 1.04374 SGSM2 - Small G protein signaling modulator 2 - Homo sapiens (Human) - SGSM2 gene Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:26620560, PubMed:21808068). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560). Taurus_UMD|evm.model.AC_000176.1.295 Q99583 MNT_HUMAN 93.537 0.996587 1.00687 MNT - Max-binding protein MNT - Homo sapiens (Human) - MNT gene Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. Taurus_UMD|evm.model.AC_000176.1.296 Q86W50 MET16_HUMAN 91.250 0.852134 1.16726 METTL16 - RNA N6-adenosine-methyltransferase METTL16 - Homo sapiens (Human) - METTL16 gene RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197299, PubMed:30197297). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197299, PubMed:30197297). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing and/or stability of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression (PubMed:28525753). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). Taurus_UMD|evm.model.AC_000176.1.297 P63004 LIS1_RAT 100.000 0.940898 1.03171 Pafah1b1 - Platelet-activating factor acetylhydrolase IB subunit alpha - Rattus norvegicus (Rat) - Pafah1b1 gene Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates to the PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (By similarity). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity). Taurus_UMD|evm.model.AC_000176.1.298 O75153 CLU_HUMAN 95.271 0.97037 1.03132 CLUH - Clustered mitochondria protein homolog - Homo sapiens (Human) - CLUH gene mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. Taurus_UMD|evm.model.AC_000176.1.300 Q5SVL6 RPGP2_MOUSE 97.917 0.286585 0.230337 Rap1gap2 - Rap1 GTPase-activating protein 2 - Mus musculus (Mouse) - Rap1gap2 gene GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. Taurus_UMD|evm.model.AC_000176.1.301 Q5E983 EF1B_BOVIN 67.742 0.981481 0.48 EEF1B - Elongation factor 1-beta - Bos taurus (Bovine) - EEF1B gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Taurus_UMD|evm.model.AC_000176.1.302 Q9BZM4 ULBP3_HUMAN 34.764 0.906542 0.877049 ULBP3 - UL16-binding protein 3 precursor - Homo sapiens (Human) - ULBP3 gene Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. Taurus_UMD|evm.model.AC_000176.1.303 Q2TA20 SPT22_BOVIN 99.725 0.994521 1.00275 SPATA22 - Spermatogenesis-associated protein 22 - Bos taurus (Bovine) - SPATA22 gene Meiosis-specific protein required for homologous recombination in meiosis I. Taurus_UMD|evm.model.AC_000176.1.304 P46446 ACY2_BOVIN 99.361 0.993631 1.00319 ASPA - Aspartoacylase - Bos taurus (Bovine) - ASPA gene Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter (By similarity). Taurus_UMD|evm.model.AC_000176.1.305 Q8NET8 TRPV3_HUMAN 94.058 0.997475 1.00253 TRPV3 - Transient receptor potential cation channel subfamily V member 3 - Homo sapiens (Human) - TRPV3 gene Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). Taurus_UMD|evm.model.AC_000176.1.306 Q697L1 TRPV1_CANLF 91.558 0.990521 1.00476 TRPV1 - Transient receptor potential cation channel subfamily V member 1 - Canis lupus familiaris (Dog) - TRPV1 gene Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH Taurus_UMD|evm.model.AC_000176.1.307 Q9UHJ6 SHPK_HUMAN 86.820 0.995825 1.00209 SHPK - Sedoheptulokinase - Homo sapiens (Human) - SHPK gene Acts as a modulator of macrophage activation through control of glucose metabolism. Taurus_UMD|evm.model.AC_000176.1.308 A7MB63 CTNS_BOVIN 100.000 0.994565 1.00272 CTNS - Cystinosin precursor - Bos taurus (Bovine) - CTNS gene Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis. In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes. Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity. Taurus_UMD|evm.model.AC_000176.1.309 O14907 TX1B3_HUMAN 99.194 0.984 1.00806 TAX1BP3 - Tax1-binding protein 3 - Homo sapiens (Human) - TAX1BP3 gene May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6. Taurus_UMD|evm.model.AC_000176.1.310 Q9CQW0 EMC6_MOUSE 99.091 0.981982 1.00909 Emc6 - ER membrane protein complex subunit 6 - Mus musculus (Mouse) - Emc6 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Taurus_UMD|evm.model.AC_000176.1.311 Q93086 P2RX5_HUMAN 67.568 0.949115 1.07109 P2RX5 - P2X purinoceptor 5 - Homo sapiens (Human) - P2RX5 gene Receptor for ATP that acts as a ligand-gated ion channel. Taurus_UMD|evm.model.AC_000176.1.312 Q60677 ITAE_MOUSE 73.649 0.90184 0.139674 Itgae - Integrin alpha-E precursor - Mus musculus (Mouse) - Itgae gene Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall. Taurus_UMD|evm.model.AC_000176.1.313 Q2KIP2 HASP_BOVIN 99.104 0.997442 1.00128 HASPIN - Serine/threonine-protein kinase haspin - Bos taurus (Bovine) - HASPIN gene Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. Taurus_UMD|evm.model.AC_000176.1.314 P38570 ITAE_HUMAN 73.633 0.96374 0.888889 ITGAE - Integrin alpha-E precursor - Homo sapiens (Human) - ITGAE gene Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Taurus_UMD|evm.model.AC_000176.1.315 Q53F19 NCBP3_HUMAN 93.069 0.973813 0.985484 NCBP3 - Nuclear cap-binding protein subunit 3 - Homo sapiens (Human) - NCBP3 gene Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). Taurus_UMD|evm.model.AC_000176.1.316 Q8N5S9 KKCC1_HUMAN 93.663 0.996047 1.00198 CAMKK1 - Calcium/calmodulin-dependent protein kinase kinase 1 - Homo sapiens (Human) - CAMKK1 gene Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. Taurus_UMD|evm.model.AC_000176.1.317 O77696 AT2A3_PIG 96.274 0.709078 1.4004 ATP2A3 - Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 - Sus scrofa (Pig) - ATP2A3 gene This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Taurus_UMD|evm.model.AC_000176.1.319 O43149 ZZEF1_HUMAN 91.745 0.999326 1.0027 ZZEF1 - Zinc finger ZZ-type and EF-hand domain-containing protein 1 - Homo sapiens (Human) - ZZEF1 gene Taurus_UMD|evm.model.AC_000176.1.320 Q8WUJ1 NEUFC_HUMAN 83.613 0.893939 1 CYB5D2 - Neuferricin precursor - Homo sapiens (Human) - CYB5D2 gene Heme-binding protein which promotes neuronal but not astrocyte differentiation. Taurus_UMD|evm.model.AC_000176.1.322 Q9P2R3 ANFY1_HUMAN 92.827 0.998314 1.01454 ANKFY1 - Rabankyrin-5 - Homo sapiens (Human) - ANKFY1 gene Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. Taurus_UMD|evm.model.AC_000176.1.323 P62255 UB2G1_RAT 100.000 0.988304 1.00588 Ube2g1 - Ubiquitin-conjugating enzyme E2 G1 - Rattus norvegicus (Rat) - Ube2g1 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4. Taurus_UMD|evm.model.AC_000176.1.324 Q6ZMD2 SPNS3_HUMAN 83.778 0.862745 1.0957 SPNS3 - Protein spinster homolog 3 - Homo sapiens (Human) - SPNS3 gene Sphingolipid transporter. Taurus_UMD|evm.model.AC_000176.1.325 Q8IVW8 SPNS2_HUMAN 93.535 0.894737 0.969035 SPNS2 - Protein spinster homolog 2 - Homo sapiens (Human) - SPNS2 gene Acts a a crucial lysosphingolipid sphingosine 1-phosphate (S1P) transporter involved in S1P secretion and function (PubMed:19074308, PubMed:23180825). S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system. Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking (PubMed:19074308, PubMed:23180825). Taurus_UMD|evm.model.AC_000176.1.327 Q9BQG0 MBB1A_HUMAN 75.481 0.994092 1.01958 MYBBP1A - Myb-binding protein 1A - Homo sapiens (Human) - MYBBP1A gene May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). Taurus_UMD|evm.model.AC_000176.1.328 A7YWM1 GGT6_BOVIN 100.000 0.995927 1.00204 GGT6 - Glutathione hydrolase 6 precursor - Bos taurus (Bovine) - GGT6 gene Cleaves glutathione conjugates. Taurus_UMD|evm.model.AC_000176.1.329 Q32KZ9 TEKT1_BOVIN 100.000 0.995227 1.00239 TEKT1 - Tektin-1 - Bos taurus (Bovine) - TEKT1 gene Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Taurus_UMD|evm.model.AC_000176.1.331 Q2KI85 SMTL2_BOVIN 100.000 0.995643 1.00218 SMTNL2 - Smoothelin-like protein 2 - Bos taurus (Bovine) - SMTNL2 gene filamentous actin, I band, M band, microtubule organizing center, protein phosphatase 1 binding, tropomyosin binding, actin cytoskeleton organization, positive regulation of vasoconstriction Taurus_UMD|evm.model.AC_000176.1.332 Q32LM4 FBX39_BOVIN 100.000 0.995495 1.00226 FBXO39 - F-box only protein 39 - Bos taurus (Bovine) - FBXO39 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000176.1.333 Q58DH1 XAF1_BOVIN 98.990 0.993289 1.00337 XAF1 - XIAP-associated factor 1 - Bos taurus (Bovine) - XAF1 gene Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity). Taurus_UMD|evm.model.AC_000176.1.334 Q86YT5 S13A5_HUMAN 82.363 0.992945 0.998239 SLC13A5 - Solute carrier family 13 member 5 - Homo sapiens (Human) - SLC13A5 gene High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol. Taurus_UMD|evm.model.AC_000176.1.336 A0JNN3 MED31_BOVIN 100.000 0.984848 1.00763 MED31 - Mediator of RNA polymerase II transcription subunit 31 - Bos taurus (Bovine) - MED31 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Taurus_UMD|evm.model.AC_000176.1.337 Q9BRA2 TXD17_HUMAN 90.244 0.983871 1.00813 TXNDC17 - Thioredoxin domain-containing protein 17 - Homo sapiens (Human) - TXNDC17 gene Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide. Taurus_UMD|evm.model.AC_000176.1.339 Q2KHM9 MOONR_HUMAN 75.155 0.997875 0.973113 KIAA0753 - Protein moonraker - Homo sapiens (Human) - KIAA0753 gene Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). Taurus_UMD|evm.model.AC_000176.1.340 Q9BZ71 PITM3_HUMAN 94.271 0.965691 1.01745 PITPNM3 - Membrane-associated phosphatidylinositol transfer protein 3 - Homo sapiens (Human) - PITPNM3 gene Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. Taurus_UMD|evm.model.AC_000176.1.341 Q9BSJ6 PIMRE_HUMAN 83.333 0.945833 0.967742 PIMREG - Protein PIMREG - Homo sapiens (Human) - PIMREG gene During mitosis, may play a role in the control of metaphase-to-anaphase transition. Taurus_UMD|evm.model.AC_000176.1.342 Q95MP1 AIPL1_BOVIN 99.390 0.993921 1.00305 AIPL1 - Aryl-hydrocarbon-interacting protein-like 1 - Bos taurus (Bovine) - AIPL1 gene May be important in protein trafficking and/or protein folding and stabilization. Taurus_UMD|evm.model.AC_000176.1.344 Q658N2 WSCD1_HUMAN 92.870 0.996528 1.00174 WSCD1 - WSC domain-containing protein 1 - Homo sapiens (Human) - WSCD1 gene Taurus_UMD|evm.model.AC_000176.1.345 Q9C000 NLRP1_HUMAN 58.632 0.991495 0.957909 NLRP1 - NACHT, LRR and PYD domains-containing protein 1 - Homo sapiens (Human) - NLRP1 gene Acts as the sensor component of the NLRP1 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis (PubMed:22665479, PubMed:12191486, PubMed:17349957, PubMed:27662089, PubMed:31484767, PubMed:33093214). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:22665479, PubMed:12191486, PubMed:17349957). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, such as cleavage by human rhinoviruses 14 and 16 (HRV-14 and HRV-16), double-stranded RNA or Val-boroPro inhibitor, and mediates the formation of the inflammasome polymeric complex composed of NLRP1, CASP1 and PYCARD/ASC (PubMed:22665479, PubMed:12191486, PubMed:17349957, PubMed:30291141, PubMed:33243852, PubMed:33093214). In response to pathogen-associated signals, the N-terminal part of NLRP1 is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1, C-terminus), which polymerizes and associates with PYCARD/ASC to initiate the formation of the inflammasome complex: the NLRP1 inflammasome recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis (PubMed:22665479, PubMed:12191486, PubMed:17349957, PubMed:32051255, PubMed:33093214). Activation of NLRP1 inflammasome is also required for HMGB1 secretion; the active cytokines and HMGB1 stimulate inflammatory responses (PubMed:22801494). Binds ATP and shows ATPase activity (PubMed:11113115, PubMed:15212762, PubMed:33243852). Plays an important role in antiviral immunity and inflammation in the human airway epithelium (PubMed:33093214). Specifically recognizes a number of pathogen-associated signals: upon infection by human rhinoviruses 14 and 16 (HRV-14 and HRV-16), NLRP1 is cleaved and activated which triggers NLRP1-dependent inflammasome activation and IL18 secretion (PubMed:33093214). Positive-strand RNA viruses such as. Semliki forest virus and long dsRNA activate the NLRP1 inflammasome, triggering IL1B release in a NLRP1-dependent fashion (PubMed:33243852). Acts as a direct sensor for long dsRNA and thus RNA virus infection (PubMed:33243852). May also be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Taurus_UMD|evm.model.AC_000176.1.347 Q5EA49 MIS12_BOVIN 100.000 0.745455 1.33495 MIS12 - Protein MIS12 homolog - Bos taurus (Bovine) - MIS12 gene Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Essential for proper kinetochore microtubule attachments. Taurus_UMD|evm.model.AC_000176.1.348 Q5RC74 DERL2_PONAB 100.000 0.991667 1.00418 DERL2 - Derlin-2 - Pongo abelii (Sumatran orangutan) - DERL2 gene Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Taurus_UMD|evm.model.AC_000176.1.349 Q9H6R0 DHX33_HUMAN 91.513 0.997167 0.998586 DHX33 - ATP-dependent RNA helicase DHX33 - Homo sapiens (Human) - DHX33 gene Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) (PubMed:21930779, PubMed:23871209, PubMed:26100019). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779). In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019). Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (PubMed:23871209). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (PubMed:23871209). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (By similarity). Taurus_UMD|evm.model.AC_000176.1.350 Q3T0B6 C1QBP_BOVIN 100.000 0.992832 1.0036 C1QBP - Complement component 1 Q subcomponent-binding protein, mitochondrial precursor - Bos taurus (Bovine) - C1QBP gene Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria. In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. May play a role in antibacterial defense. Taurus_UMD|evm.model.AC_000176.1.351 Q86UA6 RIP_HUMAN 82.192 0.990909 1.00457 RPAIN - RPA-interacting protein - Homo sapiens (Human) - RPAIN gene Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism. Taurus_UMD|evm.model.AC_000176.1.352 Q99567 NUP88_HUMAN 93.261 0.997308 1.0027 NUP88 - Nuclear pore complex protein Nup88 - Homo sapiens (Human) - NUP88 gene Component of nuclear pore complex. Taurus_UMD|evm.model.AC_000176.1.353 Q15276 RABE1_HUMAN 97.216 0.997683 1.00116 RABEP1 - Rab GTPase-binding effector protein 1 - Homo sapiens (Human) - RABEP1 gene Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). Taurus_UMD|evm.model.AC_000176.1.354 Q6UWF3 SCIMP_HUMAN 63.830 0.813953 1.18621 SCIMP - SLP adapter and CSK-interacting membrane protein - Homo sapiens (Human) - SCIMP gene Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:21930792). It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (PubMed:21930792). In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity). It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (By similarity). Taurus_UMD|evm.model.AC_000176.1.356 Q96NJ6 ZFP3_HUMAN 92.110 0.996063 1.01195 ZFP3 - Zinc finger protein 3 homolog - Homo sapiens (Human) - ZFP3 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000176.1.357 O43896 KIF1C_HUMAN 95.467 0.998187 1 KIF1C - Kinesin-like protein KIF1C - Homo sapiens (Human) - KIF1C gene Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. Taurus_UMD|evm.model.AC_000176.1.358 Q0VD86 INCA1_HUMAN 74.043 0.939516 1.05085 INCA1 - Protein INCA1 - Homo sapiens (Human) - INCA1 gene Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity). Taurus_UMD|evm.model.AC_000176.1.359 O94983 CMTA2_HUMAN 94.597 0.943606 1.04742 CAMTA2 - Calmodulin-binding transcription activator 2 - Homo sapiens (Human) - CAMTA2 gene Transcription activator. May act as tumor suppressor. Taurus_UMD|evm.model.AC_000176.1.360 O75391 SPAG7_HUMAN 98.678 0.991228 1.00441 SPAG7 - Sperm-associated antigen 7 - Homo sapiens (Human) - SPAG7 gene Taurus_UMD|evm.model.AC_000176.1.361 Q3ZC09 ENOB_BOVIN 100.000 0.981859 1.01613 ENO3 - Beta-enolase - Bos taurus (Bovine) - ENO3 gene Appears to have a function in striated muscle development and regeneration. Taurus_UMD|evm.model.AC_000176.1.362 P02584 PROF1_BOVIN 100.000 0.985816 1.00714 PFN1 - Profilin-1 - Bos taurus (Bovine) - PFN1 gene Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity). Taurus_UMD|evm.model.AC_000176.1.363 Q9H6Y7 RN167_HUMAN 95.000 0.92691 0.86 RNF167 - E3 ubiquitin-protein ligase RNF167 precursor - Homo sapiens (Human) - RNF167 gene May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition. Taurus_UMD|evm.model.AC_000176.1.364 P22292 M2OM_BOVIN 100.000 0.993651 1.00318 SLC25A11 - Mitochondrial 2-oxoglutarate/malate carrier protein - Bos taurus (Bovine) - SLC25A11 gene Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis. Taurus_UMD|evm.model.AC_000176.1.365 Q9JM99 PRG4_MOUSE 71.429 0.159754 0.617647 Prg4 - Proteoglycan 4 precursor - Mus musculus (Mouse) - Prg4 gene Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Taurus_UMD|evm.model.AC_000176.1.366 P02715 ACHE_BOVIN 100.000 0.995935 1.00204 CHRNE - Acetylcholine receptor subunit epsilon precursor - Bos taurus (Bovine) - CHRNE gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Taurus_UMD|evm.model.AC_000176.1.367 Q8N4C8 MINK1_HUMAN 97.280 0.350735 1.02102 MINK1 - Misshapen-like kinase 1 - Homo sapiens (Human) - MINK1 gene Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Taurus_UMD|evm.model.AC_000176.1.368 Q0V8L6 PLD2_BOVIN 100.000 0.997755 0.954984 PLD2 - Phospholipase D2 - Bos taurus (Bovine) - PLD2 gene Function as phospholipase selective for phosphatidylcholine. May have a role in signal-induced cytoskeletal regulation and/or endocytosis. Taurus_UMD|evm.model.AC_000176.1.369 Q3MHN0 PSB6_BOVIN 100.000 0.991667 1.00418 PSMB6 - Proteasome subunit beta type-6 precursor - Bos taurus (Bovine) - PSMB6 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolyzing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues. Taurus_UMD|evm.model.AC_000176.1.370 A6NH11 GLTD2_HUMAN 67.010 0.992857 0.962199 GLTPD2 - Glycolipid transfer protein domain-containing protein 2 - Homo sapiens (Human) - GLTPD2 gene cytosol, membrane, ceramide 1-phosphate binding, ceramide 1-phosphate transfer activity, ceramide transport, intermembrane lipid transfer Taurus_UMD|evm.model.AC_000176.1.371 Q7Z5L0 VMO1_HUMAN 77.723 0.99 0.990099 VMO1 - Vitelline membrane outer layer protein 1 homolog precursor - Homo sapiens (Human) - VMO1 gene extracellular exosome, extracellular space Taurus_UMD|evm.model.AC_000176.1.372 Q2KIG8 T4S5_BOVIN 100.000 0.989848 1.0051 TM4SF5 - Transmembrane 4 L6 family member 5 - Bos taurus (Bovine) - TM4SF5 gene Acts as a lysosomal membrane arginine sensor (By similarity). Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations (By similarity). Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus (By similarity). CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression (By similarity). Taurus_UMD|evm.model.AC_000176.1.373 Q9H091 ZMY15_HUMAN 87.931 0.981453 0.871968 ZMYND15 - Zinc finger MYND domain-containing protein 15 - Homo sapiens (Human) - ZMYND15 gene Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis. Taurus_UMD|evm.model.AC_000176.1.374 Q29RT9 CXL16_BOVIN 100.000 0.992095 1.00397 CXCL16 - C-X-C motif chemokine 16 precursor - Bos taurus (Bovine) - CXCL16 gene Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Taurus_UMD|evm.model.AC_000176.1.375 Q9P086 MED11_HUMAN 99.145 0.983051 1.00855 MED11 - Mediator of RNA polymerase II transcription subunit 11 - Homo sapiens (Human) - MED11 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Taurus_UMD|evm.model.AC_000176.1.376 P32120 ARRB2_BOVIN 97.381 0.995122 0.97619 ARRB2 - Beta-arrestin-2 - Bos taurus (Bovine) - ARRB2 gene Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which also requires GRK2. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in the internalization of the atypical chemokine receptor ACKR3 (By similarity). Acts as an adapter protein coupling FFAR4 receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis. During the activation step of NLRP3 inflammasome, directly associates with NLRP3 leading to inhibition of proinflammatory cytokine release and inhibition of inflammation. Taurus_UMD|evm.model.AC_000176.1.377 Q8IZL8 PELP1_HUMAN 88.388 0.785139 0.988496 PELP1 - Proline-, glutamic acid- and leucine-rich protein 1 - Homo sapiens (Human) - PELP1 gene Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Taurus_UMD|evm.model.AC_000176.1.378 P27479 LOX15_BOVIN 100.000 0.996988 1.00151 ALOX15 - Polyunsaturated fatty acid lipoxygenase ALOX15 - Bos taurus (Bovine) - ALOX15 gene Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE (PubMed:1539676). It may then act on 12-HPETE to produce hepoxilins, which may show proinflammatory properties (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate. May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively downregulate the immune response and have anti-aggregation properties with platelets. Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (By similarity). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function. It may also exert a negative effect on skeletal development by regulating bone mass through this pathway. As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver (By similarity). Finally, it is also involved in the cellular response to IL13/interleukin-13 (By similarity). Taurus_UMD|evm.model.AC_000176.1.379 D3ZQF9 LX12E_RAT 78.399 0.996845 0.957704 Alox12e - Polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type - Rattus norvegicus (Rat) - Alox12e gene Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:23382512). Shows increasing catalytic activity within the series arachidonic acid Taurus_UMD|evm.model.AC_000176.1.380 Q3ZBN4 CUED2_BOVIN 98.936 0.570552 0.575972 CUEDC2 - CUE domain-containing protein 2 - Bos taurus (Bovine) - CUEDC2 gene Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation. Taurus_UMD|evm.model.AC_000176.1.381 Q3ZBN4 CUED2_BOVIN 96.855 0.981366 0.568905 CUEDC2 - CUE domain-containing protein 2 - Bos taurus (Bovine) - CUEDC2 gene Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation. Taurus_UMD|evm.model.AC_000176.1.382 Q02371 NDUA3_BOVIN 75.926 0.815385 0.77381 NDUFA3 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 - Bos taurus (Bovine) - NDUFA3 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000176.1.383 P18054 LOX12_HUMAN 87.330 0.996988 1.00151 ALOX12 - Polyunsaturated fatty acid lipoxygenase ALOX12 - Homo sapiens (Human) - ALOX12 gene Catalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:17493578, PubMed:1851637, PubMed:8319693, PubMed:8500694, PubMed:18311922, PubMed:32404334). Mainly converts arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to the specific bioactive lipid (12S)-hydroperoxyeicosatetraenoate/(12S)-HPETE (PubMed:17493578, PubMed:22984144, PubMed:24282679, PubMed:8319693, PubMed:8500694). Through the production of bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation (PubMed:8319693, PubMed:8500694). It can also catalyze the epoxidation of double bonds of polyunsaturated fatty acids such as (14S)-hydroperoxy-docosahexaenoate/(14S)-HPDHA resulting in the formation of (13S,14S)-epoxy-DHA (PubMed:23504711). Furthermore, it may participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively downregulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). An additional function involves a multistep process by which it transforms leukotriene A4/LTA4 into the bioactive lipids lipoxin A4/LXA4 and lipoxin B4/LXB4, both are vasoactive and LXA4 may regulate neutrophil function via occupancy of specific recognition sites (PubMed:8250832). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to (13S)-hydroperoxyoctadecadienoate/ (13S-HPODE) (By similarity). Due to its role in regulating both the expression of the vascular endothelial growth factor (VEGF, an angiogenic factor involved in the survival and metastasis of solid tumors) and the expression of integrin beta-1 (known to affect tumor cell migration and proliferation), it can be regarded as protumorigenic (PubMed:9751607, PubMed:16638750, PubMed:22237009). Important for cell survival, as it may play a role not only in proliferation but also in the prevention of apoptosis in vascular smooth muscle cells (PubMed:23578768). Taurus_UMD|evm.model.AC_000176.1.384 Q3ZC23 RNK_BOVIN 100.000 0.638158 1.55102 RNASEK - Ribonuclease kappa - Bos taurus (Bovine) - RNASEK gene Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate (By similarity). Taurus_UMD|evm.model.AC_000176.1.385 Q32LD1 BAP18_BOVIN 100.000 0.988439 1.00581 BAP18 - Chromatin complexes subunit BAP18 - Bos taurus (Bovine) - BAP18 gene Component of chromatin complexes such as the MLL1/MLL and NURF complexes. Taurus_UMD|evm.model.AC_000176.1.386 Q8N143 BCL6B_HUMAN 92.067 0.995781 0.989562 BCL6B - B-cell CLL/lymphoma 6 member B protein - Homo sapiens (Human) - BCL6B gene Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development. Taurus_UMD|evm.model.AC_000176.1.387 Q17QR6 MOT13_BOVIN 100.000 0.995316 1.00235 SLC16A13 - Monocarboxylate transporter 13 - Bos taurus (Bovine) - SLC16A13 gene Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. Taurus_UMD|evm.model.AC_000176.1.388 Q8NCK7 MOT11_HUMAN 84.564 0.995536 0.951168 SLC16A11 - Monocarboxylate transporter 11 - Homo sapiens (Human) - SLC16A11 gene Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane (PubMed:28666119). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids (PubMed:24390345). Taurus_UMD|evm.model.AC_000176.1.389 Q8IUN9 CLC10_HUMAN 58.387 0.987055 0.977848 CLEC10A - C-type lectin domain family 10 member A - Homo sapiens (Human) - CLEC10A gene Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells. Taurus_UMD|evm.model.AC_000176.1.390 P07307 ASGR2_HUMAN 70.455 0.990066 0.971061 ASGR2 - Asialoglycoprotein receptor 2 - Homo sapiens (Human) - ASGR2 gene Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. Taurus_UMD|evm.model.AC_000176.1.391 P07306 ASGR1_HUMAN 80.851 0.97561 0.986254 ASGR1 - Asialoglycoprotein receptor 1 - Homo sapiens (Human) - ASGR1 gene Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. Taurus_UMD|evm.model.AC_000176.1.392 P78352 DLG4_HUMAN 94.980 0.997351 1.04282 DLG4 - Disks large homolog 4 - Homo sapiens (Human) - DLG4 gene Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. Taurus_UMD|evm.model.AC_000176.1.393 P48818 ACADV_BOVIN 100.000 0.996951 1.00153 ACADVL - Very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ACADVL gene Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains. Taurus_UMD|evm.model.AC_000176.1.394 O14641 DVL2_HUMAN 97.690 0.997286 1.00136 DVL2 - Segment polarity protein dishevelled homolog DVL-2 - Homo sapiens (Human) - DVL2 gene Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Taurus_UMD|evm.model.AC_000176.1.395 A5D962 PHF23_BOVIN 97.277 0.995062 1.0125 PHF23 - PHD finger protein 23 - Bos taurus (Bovine) - PHF23 gene Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria. Taurus_UMD|evm.model.AC_000176.1.396 P60517 GBRAP_RAT 100.000 0.983051 1.00855 Gabarap - Gamma-aminobutyric acid receptor-associated protein precursor - Rattus norvegicus (Rat) - Gabarap gene Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (PubMed:11461150). Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (By similarity). Also required for the local activition of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination a nd degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction. Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation (By similarity). Involved in apoptosis (By similarity). Taurus_UMD|evm.model.AC_000176.1.397 Q1RMV9 CNEP1_BOVIN 100.000 0.991837 1.0041 CTDNEP1 - CTD nuclear envelope phosphatase 1 - Bos taurus (Bovine) - CTDNEP1 gene Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity). Taurus_UMD|evm.model.AC_000176.1.398 Q8TE02 ELP5_HUMAN 83.566 0.946844 0.952532 ELP5 - Elongator complex protein 5 - Homo sapiens (Human) - ELP5 gene Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:22854966). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation (PubMed:16850183). Taurus_UMD|evm.model.AC_000176.1.399 Q3B7N4 CLD7_BOVIN 100.000 0.990566 1.00474 CLDN7 - Claudin-7 - Bos taurus (Bovine) - CLDN7 gene Plays a major role in tight junction-specific obliteration of the intercellular space. Taurus_UMD|evm.model.AC_000176.1.400 Q27994 GLUT4_BOVIN 93.798 0.883162 1.14342 SLC2A4 - Solute carrier family 2, facilitated glucose transporter member 4 - Bos taurus (Bovine) - SLC2A4 gene Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. Taurus_UMD|evm.model.AC_000176.1.401 Q9Z2C8 YBOX2_MOUSE 97.000 0.828255 1.00278 Ybx2 - Y-box-binding protein 2 - Mus musculus (Mouse) - Ybx2 gene Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay. Taurus_UMD|evm.model.AC_000176.1.402 Q3T1J1 IF5A1_RAT 100.000 0.987097 1.00649 Eif5a - Eukaryotic translation initiation factor 5A-1 - Rattus norvegicus (Rat) - Eif5a gene mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival (By similarity). May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Taurus_UMD|evm.model.AC_000176.1.403 Q13227 GPS2_HUMAN 98.777 0.17086 5.83486 GPS2 - G protein pathway suppressor 2 - Homo sapiens (Human) - GPS2 gene Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination (By similarity). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:24943844). Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (By similarity). Promotes cholesterol efflux by acting as a transcription coactivator (PubMed:19481530). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (By similarity). Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes (PubMed:29499132). Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132). Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG (PubMed:19858209, PubMed:24943844). Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation (PubMed:20159957). In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways (By similarity). In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the proinflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13 activity (By similarity). In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13-mediated ubiquitination of AKT (By similarity). Able to suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction (PubMed:8943324). Acts as a tumor-suppressor in liposarcoma (PubMed:27460081). Taurus_UMD|evm.model.AC_000176.1.404 Q3SZX2 IPP2_BOVIN 45.638 0.247601 2.51691 PPP1R2 - Protein phosphatase inhibitor 2 - Bos taurus (Bovine) - PPP1R2 gene Inhibitor of protein-phosphatase 1. Taurus_UMD|evm.model.AC_000176.1.405 A5PK26 ACAP1_BOVIN 99.329 0.997305 0.995973 ACAP1 - Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 - Bos taurus (Bovine) - ACAP1 gene GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration (By similarity). Taurus_UMD|evm.model.AC_000176.1.406 Q58DF7 KCD11_BOVIN 99.569 0.991416 1.00431 KCTD11 - BTB/POZ domain-containing protein KCTD11 - Bos taurus (Bovine) - KCTD11 gene Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive (By similarity). Taurus_UMD|evm.model.AC_000176.1.407 A0A3Q1LRJ2 TMM95_BOVIN 72.038 0.954128 1.31325 TMEM95 - Sperm-egg fusion protein TMEM95 precursor - Bos taurus (Bovine) - TMEM95 gene Sperm protein required for fusion of sperm with the egg membrane during fertilization. Taurus_UMD|evm.model.AC_000176.1.408 Q13470 TNK1_HUMAN 82.459 0.996956 0.986486 TNK1 - Non-receptor tyrosine-protein kinase TNK1 - Homo sapiens (Human) - TNK1 gene Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. Taurus_UMD|evm.model.AC_000176.1.409 Q9NRY6 PLS3_HUMAN 92.409 0.993421 1.03051 PLSCR3 - Phospholipid scramblase 3 - Homo sapiens (Human) - PLSCR3 gene Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:29337693, PubMed:31769662). Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:12649167). Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (PubMed:14573790, PubMed:17226776, PubMed:18358005). Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (PubMed:18491232). Regulates cardiolipin de novo biosynthesis and its resynthesis (PubMed:16939411). Taurus_UMD|evm.model.AC_000176.1.410 Q2KI29 TM256_BOVIN 100.000 0.982456 1.00885 TMEM256 - Transmembrane protein 256 precursor - Bos taurus (Bovine) - TMEM256 gene Taurus_UMD|evm.model.AC_000176.1.411 Q8NFZ4 NLGN2_HUMAN 97.297 0.9819 0.794012 NLGN2 - Neuroligin-2 precursor - Homo sapiens (Human) - NLGN2 gene Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). Taurus_UMD|evm.model.AC_000176.1.412 Q0P670 SPEM2_HUMAN 65.310 0.918 0.998004 SPEM2 - Uncharacterized protein SPEM2 - Homo sapiens (Human) - SPEM2 gene Taurus_UMD|evm.model.AC_000176.1.413 A0A1B0GUW6 SPEM3_HUMAN 54.049 0.372981 1.1388 SPEM3 - Uncharacterized protein SPEM3 - Homo sapiens (Human) - SPEM3 gene Taurus_UMD|evm.model.AC_000176.1.414 Q1LZD1 TM102_BOVIN 100.000 0.996101 1.00195 TMEM102 - Transmembrane protein 102 - Bos taurus (Bovine) - TMEM102 gene Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway. Taurus_UMD|evm.model.AC_000176.1.415 P70378 FGF11_MOUSE 99.107 0.986726 1.00444 Fgf11 - Fibroblast growth factor 11 - Mus musculus (Mouse) - Fgf11 gene Probably involved in nervous system development and function. Taurus_UMD|evm.model.AC_000176.1.416 P04758 ACHB_BOVIN 100.000 0.996047 1.00198 CHRNB1 - Acetylcholine receptor subunit beta precursor - Bos taurus (Bovine) - CHRNB1 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Taurus_UMD|evm.model.AC_000176.1.417 Q9P1Z0 ZBTB4_HUMAN 88.791 0.99802 0.997038 ZBTB4 - Zinc finger and BTB domain-containing protein 4 - Homo sapiens (Human) - ZBTB4 gene Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). Taurus_UMD|evm.model.AC_000176.1.418 Q5F297 S35G3_MOUSE 89.676 0.722581 1.36765 Slc35g3 - Solute carrier family 35 member G3 - Mus musculus (Mouse) - Slc35g3 gene integral component of membrane Taurus_UMD|evm.model.AC_000176.1.419 P08775 RPB1_MOUSE 94.572 0.984615 0.989848 Polr2a - DNA-directed RNA polymerase II subunit RPB1 - Mus musculus (Mouse) - Polr2a gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates (By similarity). Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing (By similarity). Regulation of gene expression levels depends on the balance between methylation and acetylation levels of tha CTD-lysines (PubMed:26687004). Initiation or early elongation steps of transcription of growth-factors-induced immediate early genes are regulated by the acetylation status of the CTD (PubMed:24207025). Methylation and dimethylation have a repressive effect on target genes expression (PubMed:26687004). Taurus_UMD|evm.model.AC_000176.1.420 O43508 TNF12_HUMAN 84.681 0.624665 1.49799 TNFSF12 - Tumor necrosis factor ligand superfamily member 12 - Homo sapiens (Human) - TNFSF12 gene Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. Taurus_UMD|evm.model.AC_000176.1.421 Q9H4L4 SENP3_HUMAN 96.167 0.738402 1.35192 SENP3 - Sentrin-specific protease 3 - Homo sapiens (Human) - SENP3 gene Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Taurus_UMD|evm.model.AC_000176.1.422 P60843 IF4A1_MOUSE 100.000 0.995086 1.00246 Eif4a1 - Eukaryotic initiation factor 4A-I - Mus musculus (Mouse) - Eif4a1 gene ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Taurus_UMD|evm.model.AC_000176.1.423 P34810 CD68_HUMAN 72.067 0.994048 0.949153 CD68 - Macrosialin precursor - Homo sapiens (Human) - CD68 gene Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Taurus_UMD|evm.model.AC_000176.1.424 O75352 MPU1_HUMAN 93.469 0.987854 1 MPDU1 - Mannose-P-dolichol utilization defect 1 protein - Homo sapiens (Human) - MPDU1 gene Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors. Taurus_UMD|evm.model.AC_000176.1.425 O60248 SOX15_HUMAN 81.116 0.991453 1.00429 SOX15 - Protein SOX-15 - Homo sapiens (Human) - SOX15 gene Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity). Acts as a transcriptional activator and repressor (By similarity). Binds synergistically with POU5F1 (OCT3/4) to gene promoters (By similarity). Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (By similarity). Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (By similarity). Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (By similarity). Regulates transcription of HRC via binding to it proximal enhancer region (By similarity). Involved in skeletal muscle regeneration (By similarity). Also plays a role in the development of myogenic precursor cells (By similarity). Taurus_UMD|evm.model.AC_000176.1.426 P51116 FXR2_HUMAN 98.251 0.789937 1.18128 FXR2 - Fragile X mental retardation syndrome-related protein 2 - Homo sapiens (Human) - FXR2 gene RNA-binding protein. Taurus_UMD|evm.model.AC_000176.1.427 P04278 SHBG_HUMAN 74.876 0.938967 1.0597 SHBG - Sex hormone-binding globulin precursor - Homo sapiens (Human) - SHBG gene Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. Taurus_UMD|evm.model.AC_000176.1.428 Q5J583 AT1B2_OCHCU 99.310 0.993127 1.00345 ATP1B2 - Sodium/potassium-transporting ATPase subunit beta-2 - Ochotona curzoniae (Black-lipped pika) - ATP1B2 gene This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known (By similarity). Taurus_UMD|evm.model.AC_000176.1.429 P67939 P53_BOVIN 100.000 0.994832 1.00259 TP53 - Cellular tumor antigen p53 - Bos taurus (Bovine) - TP53 gene Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2. Taurus_UMD|evm.model.AC_000176.1.430 Q3SWZ7 TCAB1_BOVIN 99.815 0.996303 1.00185 WRAP53 - Telomerase Cajal body protein 1 - Bos taurus (Bovine) - WRAP53 gene RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity. In addition, also controls telomerase holoenzyme complex localization to Cajal body. During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity. In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies. Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks. Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ). Taurus_UMD|evm.model.AC_000176.1.431 Q15768 EFNB3_HUMAN 96.765 0.994135 1.00294 EFNB3 - Ephrin-B3 precursor - Homo sapiens (Human) - EFNB3 gene Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). Taurus_UMD|evm.model.AC_000176.1.432 Q9P225 DYH2_HUMAN 93.314 0.895718 1.01807 DNAH2 - Dynein axonemal heavy chain 2 - Homo sapiens (Human) - DNAH2 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Taurus_UMD|evm.model.AC_000176.1.433 O15054 KDM6B_HUMAN 92.187 0.998785 1.00183 KDM6B - Lysine-specific demethylase 6B - Homo sapiens (Human) - KDM6B gene Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). Taurus_UMD|evm.model.AC_000176.1.434 A5D7M7 TMM88_BOVIN 100.000 0.9875 1.00629 TMEM88 - Transmembrane protein 88 - Bos taurus (Bovine) - TMEM88 gene Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity). Taurus_UMD|evm.model.AC_000176.1.435 Q9BRA0 LSMD1_HUMAN 96.825 0.984252 1.016 NAA38 - N-alpha-acetyltransferase 38, NatC auxiliary subunit - Homo sapiens (Human) - NAA38 gene Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Taurus_UMD|evm.model.AC_000176.1.437 Q12873 CHD3_HUMAN 97.543 0.990045 1.0045 CHD3 - Chromodomain-helicase-DNA-binding protein 3 - Homo sapiens (Human) - CHD3 gene Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones (PubMed:9804427, PubMed:30397230). Involved in transcriptional repressiobn as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). Taurus_UMD|evm.model.AC_000176.1.438 A6NIN4 RN227_HUMAN 75.132 0.983696 0.968421 RNF227 - RING finger protein 227 - Homo sapiens (Human) - RNF227 gene Taurus_UMD|evm.model.AC_000176.1.439 O43448 KCAB3_HUMAN 93.564 0.995 0.990099 KCNAB3 - Voltage-gated potassium channel subunit beta-3 - Homo sapiens (Human) - KCNAB3 gene Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5. Taurus_UMD|evm.model.AC_000176.1.440 Q9Y5R8 TPPC1_HUMAN 100.000 0.791209 1.25517 TRAPPC1 - Trafficking protein particle complex subunit 1 - Homo sapiens (Human) - TRAPPC1 gene May play a role in vesicular transport from endoplasmic reticulum to Golgi. Taurus_UMD|evm.model.AC_000176.1.441 Q8N137 CNTRB_HUMAN 88.442 0.864629 0.253599 CNTROB - Centrobin - Homo sapiens (Human) - CNTROB gene Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. Taurus_UMD|evm.model.AC_000176.1.442 Q8N137 CNTRB_HUMAN 90.000 0.913793 0.192691 CNTROB - Centrobin - Homo sapiens (Human) - CNTROB gene Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. Taurus_UMD|evm.model.AC_000176.1.443 Q8N137 CNTRB_HUMAN 83.617 0.985294 0.527132 CNTROB - Centrobin - Homo sapiens (Human) - CNTROB gene Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. Taurus_UMD|evm.model.AC_000176.1.444 P55203 GUC2D_BOVIN 99.730 0.9982 1.0009 GUCY2D - Retinal guanylyl cyclase 1 precursor - Bos taurus (Bovine) - GUCY2D gene Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:8102054). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity). Taurus_UMD|evm.model.AC_000176.1.446 O15296 LX15B_HUMAN 82.422 0.99705 1.00296 ALOX15B - Polyunsaturated fatty acid lipoxygenase ALOX15B - Homo sapiens (Human) - ALOX15B gene Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators (PubMed:9177185, PubMed:10625675, PubMed:12704195, PubMed:17493578, PubMed:18311922, PubMed:24282679, PubMed:10542053, PubMed:24497644, PubMed:32404334) (Probable). It inserts peroxyl groups at C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing (15S)-hydroperoxyeicosatetraenoate/(15S)-HPETE (PubMed:17493578, PubMed:12704195, PubMed:24282679, PubMed:9177185, PubMed:11956198, PubMed:10625675, PubMed:24497644) (Probable). Also peroxidizes linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (Probable) (PubMed:10542053, PubMed:27435673). Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoyl glycerol (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist (PubMed:18311922, PubMed:17493578, PubMed:11956198). Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates (PubMed:27145229). Participates in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) resolvin D5 ((7S,17S)-diHPDHA), which can actively downregulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). In addition to free PUFAs hydrolyzed from phospholipids, it directly oxidizes PUFAs esterified to membrane-bound phospholipids (PubMed:27435673). Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation (PubMed:12704195, PubMed:11839751). May also regulate cytokine secretion by macrophages and therefore play a role in the immune response (PubMed:18067895). May also regulate macrophage differentiation into proatherogenic foam cells (PubMed:22912809). Taurus_UMD|evm.model.AC_000176.1.447 O15296 LX15B_HUMAN 60.317 0.167568 0.547337 ALOX15B - Polyunsaturated fatty acid lipoxygenase ALOX15B - Homo sapiens (Human) - ALOX15B gene Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators (PubMed:9177185, PubMed:10625675, PubMed:12704195, PubMed:17493578, PubMed:18311922, PubMed:24282679, PubMed:10542053, PubMed:24497644, PubMed:32404334) (Probable). It inserts peroxyl groups at C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing (15S)-hydroperoxyeicosatetraenoate/(15S)-HPETE (PubMed:17493578, PubMed:12704195, PubMed:24282679, PubMed:9177185, PubMed:11956198, PubMed:10625675, PubMed:24497644) (Probable). Also peroxidizes linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (Probable) (PubMed:10542053, PubMed:27435673). Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoyl glycerol (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist (PubMed:18311922, PubMed:17493578, PubMed:11956198). Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates (PubMed:27145229). Participates in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) resolvin D5 ((7S,17S)-diHPDHA), which can actively downregulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). In addition to free PUFAs hydrolyzed from phospholipids, it directly oxidizes PUFAs esterified to membrane-bound phospholipids (PubMed:27435673). Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation (PubMed:12704195, PubMed:11839751). May also regulate cytokine secretion by macrophages and therefore play a role in the immune response (PubMed:18067895). May also regulate macrophage differentiation into proatherogenic foam cells (PubMed:22912809). Taurus_UMD|evm.model.AC_000176.1.448 O75342 LX12B_HUMAN 88.160 0.997143 0.998573 ALOX12B - Arachidonate 12-lipoxygenase, 12R-type - Homo sapiens (Human) - ALOX12B gene Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:9837935, PubMed:9618483, PubMed:21558561). In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (PubMed:21558561). Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:21558561). May also play a role in the regulation of the expression of airway mucins (PubMed:22441738). Taurus_UMD|evm.model.AC_000176.1.449 Q9BYJ1 LOXE3_HUMAN 89.170 0.771739 1.29395 ALOXE3 - Hydroperoxide isomerase ALOXE3 - Homo sapiens (Human) - ALOXE3 gene Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity (PubMed:12881489, PubMed:17045234, PubMed:20921226, PubMed:20923767). The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones (PubMed:12881489, PubMed:17045234, PubMed:20923767). In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides (PubMed:20921226). In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (PubMed:21558561). Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:21558561). In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites (PubMed:21558561). Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (By similarity). Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (By similarity). Taurus_UMD|evm.model.AC_000176.1.450 O15534 PER1_HUMAN 90.310 0.996109 0.996124 PER1 - Period circadian protein homolog 1 - Homo sapiens (Human) - PER1 gene Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/ARNTL target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by ARNTL:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Taurus_UMD|evm.model.AC_000176.1.451 P63026 VAMP2_BOVIN 98.684 0.619835 1.0431 VAMP2 - Vesicle-associated membrane protein 2 - Bos taurus (Bovine) - VAMP2 gene Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity). Taurus_UMD|evm.model.AC_000176.1.452 Q642C0 DNJC8_RAT 94.170 0.917355 0.956522 Dnajc8 - DnaJ homolog subfamily C member 8 - Rattus norvegicus (Rat) - Dnajc8 gene Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells. Taurus_UMD|evm.model.AC_000176.1.453 Q6UX40 TM107_HUMAN 92.143 0.985816 1.00714 TMEM107 - Transmembrane protein 107 - Homo sapiens (Human) - TMEM107 gene Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (PubMed:26518474). Taurus_UMD|evm.model.AC_000176.1.454 Q3SX20 BORC6_BOVIN 100.000 0.99435 1.00283 BORCS6 - BLOC-1-related complex subunit 6 - Bos taurus (Bovine) - BORCS6 gene As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Taurus_UMD|evm.model.AC_000176.1.455 Q7YRC6 AURKB_BOVIN 99.709 0.994203 1.00291 AURKB - Aurora kinase B - Bos taurus (Bovine) - AURKB gene Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Taurus_UMD|evm.model.AC_000176.1.456 Q2NKJ3 CTC1_HUMAN 76.721 0.998348 0.99507 CTC1 - CST complex subunit CTC1 - Homo sapiens (Human) - CTC1 gene Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097). Involved in telomere maintenance (PubMed:19854131, PubMed:22863775). Involved in genome stability (PubMed:22863775). May be in involved in telomeric C-strand fill-in during late S/G2 phase (By similarity). Taurus_UMD|evm.model.AC_000176.1.457 O15067 PUR4_HUMAN 89.013 0.977339 1.02242 PFAS - Phosphoribosylformylglycinamidine synthase - Homo sapiens (Human) - PFAS gene Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity). Taurus_UMD|evm.model.AC_000176.1.458 Q32PE2 MOG1_BOVIN 98.387 0.989305 1.00538 RANGRF - Ran guanine nucleotide release factor - Bos taurus (Bovine) - RANGRF gene May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes. Taurus_UMD|evm.model.AC_000176.1.459 Q3KQZ1 S2535_HUMAN 92.667 0.993355 1.00333 SLC25A35 - Solute carrier family 25 member 35 - Homo sapiens (Human) - SLC25A35 gene Taurus_UMD|evm.model.AC_000176.1.460 O94989 ARHGF_HUMAN 86.541 0.997642 1.00832 ARHGEF15 - Rho guanine nucleotide exchange factor 15 - Homo sapiens (Human) - ARHGEF15 gene Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. Taurus_UMD|evm.model.AC_000176.1.461 Q0II41 ODFP4_BOVIN 98.477 0.566474 1.73869 ODF4 - Outer dense fiber protein 4 - Bos taurus (Bovine) - ODF4 gene Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton. Taurus_UMD|evm.model.AC_000176.1.462 Q6ZNG9 KRBA2_HUMAN 86.792 0.898089 0.957317 KRBA2 - KRAB-A domain-containing protein 2 - Homo sapiens (Human) - KRBA2 gene Taurus_UMD|evm.model.AC_000176.1.463 P61255 RL26_MOUSE 100.000 0.386059 2.57241 Rpl26 - 60S ribosomal protein L26 - Mus musculus (Mouse) - Rpl26 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000176.1.464 O46480 NDEL1_RABIT 99.130 0.99422 1.0029 NDEL1 - Nuclear distribution protein nudE-like 1 - Oryctolagus cuniculus (Rabbit) - NDEL1 gene Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Taurus_UMD|evm.model.AC_000176.1.465 Q27991 MYH10_BOVIN 100.000 0.987994 1.01164 MYH10 - Myosin-10 - Bos taurus (Bovine) - MYH10 gene Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). Taurus_UMD|evm.model.AC_000176.1.468 A6QQM8 CCD42_BOVIN 100.000 0.993691 1.00316 CCDC42 - Coiled-coil domain-containing protein 42 - Bos taurus (Bovine) - CCDC42 gene Required for sperm development. Taurus_UMD|evm.model.AC_000176.1.469 Q8IWD5 MFS6L_HUMAN 70.202 0.991639 1.02048 MFSD6L - Major facilitator superfamily domain-containing protein 6-like - Homo sapiens (Human) - MFSD6L gene membrane Taurus_UMD|evm.model.AC_000176.1.470 Q5UE93 PI3R6_HUMAN 82.590 0.871698 1.05438 PIK3R6 - Phosphoinositide 3-kinase regulatory subunit 6 - Homo sapiens (Human) - PIK3R6 gene Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. Taurus_UMD|evm.model.AC_000176.1.471 O02696 PI3R5_PIG 84.831 0.997658 0.973774 PIK3R5 - Phosphoinositide 3-kinase regulatory subunit 5 - Sus scrofa (Pig) - PIK3R5 gene Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG. Taurus_UMD|evm.model.AC_000176.1.472 O95631 NET1_HUMAN 99.668 0.996689 1 NTN1 - Netrin-1 precursor - Homo sapiens (Human) - NTN1 gene Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335). Taurus_UMD|evm.model.AC_000176.1.473 Q3T075 STX8_BOVIN 100.000 0.920863 0.588983 STX8 - Syntaxin-8 - Bos taurus (Bovine) - STX8 gene Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER. Taurus_UMD|evm.model.AC_000176.1.474 Q8N1V2 CFA52_HUMAN 90.805 0.987013 0.993548 CFAP52 - Cilia- and flagella-associated protein 52 - Homo sapiens (Human) - CFAP52 gene May play a role in cell growth and/or survival. Taurus_UMD|evm.model.AC_000176.1.475 Q70EL4 UBP43_HUMAN 79.193 0.969271 1.01425 USP43 - Ubiquitin carboxyl-terminal hydrolase 43 - Homo sapiens (Human) - USP43 gene May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Taurus_UMD|evm.model.AC_000176.1.476 Q1RMJ5 DRS7C_BOVIN 99.679 0.545614 1.8328 DHRS7C - Dehydrogenase/reductase SDR family member 7C precursor - Bos taurus (Bovine) - DHRS7C gene Putative oxidoreductase. Taurus_UMD|evm.model.AC_000176.1.477 O95838 GLP2R_HUMAN 78.758 0.766154 1.17541 GLP2R - Glucagon-like peptide 2 receptor - Homo sapiens (Human) - GLP2R gene This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Taurus_UMD|evm.model.AC_000176.1.478 P21457 RECO_BOVIN 100.000 0.990148 1.00495 RCVRN - Recoverin - Bos taurus (Bovine) - RCVRN gene Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (PubMed:1672047, PubMed:1672637). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (PubMed:1672047, PubMed:1672637, PubMed:8392055, PubMed:16675451, PubMed:21299498, PubMed:12686556, PubMed:17015448). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity). Taurus_UMD|evm.model.AC_000176.1.479 O60861 GAS7_HUMAN 97.143 0.994286 0.367647 GAS7 - Growth arrest-specific protein 7 - Homo sapiens (Human) - GAS7 gene May play a role in promoting maturation and morphological differentiation of cerebellar neurons. Taurus_UMD|evm.model.AC_000176.1.480 Q076A3 MYH13_CANLF 94.473 0.95128 1.04742 MYH13 - Myosin-13 - Canis lupus familiaris (Dog) - MYH13 gene Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. Taurus_UMD|evm.model.AC_000176.1.481 Q076A4 MYH8_CANLF 97.318 0.998968 0.999484 MYH8 - Myosin-8 - Canis lupus familiaris (Dog) - MYH8 gene Muscle contraction. Taurus_UMD|evm.model.AC_000176.1.482 Q9TV62 MYH4_PIG 97.162 0.998969 1.00103 MYH4 - Myosin-4 - Sus scrofa (Pig) - MYH4 gene Muscle contraction. Taurus_UMD|evm.model.AC_000176.1.483 Q9BE40 MYH1_BOVIN 100.000 0.998969 1.00052 MYH1 - Myosin-1 - Bos taurus (Bovine) - MYH1 gene Muscle contraction. Taurus_UMD|evm.model.AC_000176.1.484 Q9BE41 MYH2_BOVIN 99.948 0.968048 1.03247 MYH2 - Myosin-2 - Bos taurus (Bovine) - MYH2 gene Muscle contraction. Required for cytoskeleton organization (By similarity). Taurus_UMD|evm.model.AC_000176.1.485 P11055 MYH3_HUMAN 95.582 0.979592 1.03557 MYH3 - Myosin-3 - Homo sapiens (Human) - MYH3 gene Muscle contraction. Taurus_UMD|evm.model.AC_000176.1.486 A1A4J8 SCO1_BOVIN 100.000 0.62423 1.59672 SCO1 - Protein SCO1 homolog, mitochondrial precursor - Bos taurus (Bovine) - SCO1 gene Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1. Taurus_UMD|evm.model.AC_000176.1.487 A7YY53 ADPRM_BOVIN 99.703 0.994083 1.00297 ADPRM - Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase - Bos taurus (Bovine) - ADPRM gene Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity). Taurus_UMD|evm.model.AC_000176.1.488 Q8BP07 TM220_MOUSE 76.048 0.988095 1.00599 Tmem220 - Transmembrane protein 220 - Mus musculus (Mouse) - Tmem220 gene Taurus_UMD|evm.model.AC_000176.1.489 A6NJY4 T238L_HUMAN 72.152 0.678261 1.4557 TMEM238L - Transmembrane protein 238-like - Homo sapiens (Human) - TMEM238L gene Taurus_UMD|evm.model.AC_000176.1.490 P0C851 PIRT_HUMAN 85.185 0.985294 0.992701 PIRT - Phosphoinositide-interacting protein - Homo sapiens (Human) - PIRT gene Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity). Taurus_UMD|evm.model.AC_000176.1.491 Q3UH99 SHSA6_MOUSE 87.426 0.978641 0.980952 Shisa6 - Protein shisa-6 precursor - Mus musculus (Mouse) - Shisa6 gene Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (PubMed:26931375). May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway (PubMed:28196692). Taurus_UMD|evm.model.AC_000176.1.492 Q9NYC9 DYH9_HUMAN 85.083 0.996626 0.991083 DNAH9 - Dynein axonemal heavy chain 9 - Homo sapiens (Human) - DNAH9 gene Force generating protein required for cilia beating in respiratory epithelia (PubMed:30471717, PubMed:30471718). Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Taurus_UMD|evm.model.AC_000176.1.493 P17022 ZNF18_HUMAN 74.701 0.991984 0.908925 ZNF18 - Zinc finger protein 18 - Homo sapiens (Human) - ZNF18 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000176.1.494 P45985 MP2K4_HUMAN 98.753 0.744879 1.34586 MAP2K4 - Dual specificity mitogen-activated protein kinase kinase 4 - Homo sapiens (Human) - MAP2K4 gene Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. Taurus_UMD|evm.model.AC_000176.1.497 Q7YR76 MYCD_PIG 82.937 0.997925 1.03323 MYOCD - Myocardin - Sus scrofa (Pig) - MYOCD gene Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). Taurus_UMD|evm.model.AC_000176.1.498 Q17R89 RHG44_HUMAN 92.430 0.997543 0.99511 ARHGAP44 - Rho GTPase-activating protein 44 - Homo sapiens (Human) - ARHGAP44 gene GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity). Taurus_UMD|evm.model.AC_000176.1.499 Q8HY87 RNZ2_MACFA 81.829 0.997487 0.96368 ELAC2 - Zinc phosphodiesterase ELAC protein 2 precursor - Macaca fascicularis (Crab-eating macaque) - ELAC2 gene Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. Taurus_UMD|evm.model.AC_000176.1.500 Q8BKN6 HS3SA_MOUSE 90.196 0.990244 0.521628 Hs3st3a1 - Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 - Mus musculus (Mouse) - Hs3st3a1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). Taurus_UMD|evm.model.AC_000176.1.501 Q9QZS6 HS3SB_MOUSE 98.113 0.26 0.512821 Hs3st3b1 - Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 - Mus musculus (Mouse) - Hs3st3b1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). Taurus_UMD|evm.model.AC_000176.1.503 Q12887 COX10_HUMAN 85.553 0.995495 1.00226 COX10 - Protoheme IX farnesyltransferase, mitochondrial precursor - Homo sapiens (Human) - COX10 gene Converts protoheme IX and farnesyl diphosphate to heme O. Taurus_UMD|evm.model.AC_000176.1.504 Q8BKN6 HS3SA_MOUSE 91.860 0.660668 0.989822 Hs3st3a1 - Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 - Mus musculus (Mouse) - Hs3st3a1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). Taurus_UMD|evm.model.AC_000176.1.505 Q9TQZ3 PMP22_BOVIN 100.000 0.987578 1.00625 PMP22 - Peripheral myelin protein 22 - Bos taurus (Bovine) - PMP22 gene Might be involved in growth regulation, and in myelinization in the peripheral nervous system. Taurus_UMD|evm.model.AC_000176.1.506 A6H782 TEKT3_BOVIN 99.184 0.995927 1.00204 TEKT3 - Tektin-3 - Bos taurus (Bovine) - TEKT3 gene May be a structural component of the sperm flagellum. Required for normal sperm mobility (By similarity). Taurus_UMD|evm.model.AC_000176.1.507 Q2YDL7 CDRT4_BOVIN 99.379 0.463768 2.10366 CDRT4 - CMT1A duplicated region transcript 4 protein homolog - Bos taurus (Bovine) - CDRT4 gene Taurus_UMD|evm.model.AC_000176.1.508 Q29S14 TV23B_BOVIN 100.000 0.990431 1.00481 TVP23B - Golgi apparatus membrane protein TVP23 homolog B - Bos taurus (Bovine) - TVP23B gene integral component of Golgi membrane, protein secretion, vesicle-mediated transport Taurus_UMD|evm.model.AC_000176.1.509 O95170 CDRT1_HUMAN 75.480 0.623041 1.44282 CDRT1 - CMT1A duplicated region transcript 1 protein - Homo sapiens (Human) - CDRT1 gene Taurus_UMD|evm.model.AC_000176.1.510 Q309B1 TR16L_HUMAN 75.434 0.612789 1.61782 TRIM16L - Tripartite motif-containing protein 16-like protein - Homo sapiens (Human) - TRIM16L gene cytosol, plasma membrane Taurus_UMD|evm.model.AC_000176.1.511 Q9HBT8 Z286A_HUMAN 87.716 0.88586 1.12668 ZNF286A - Zinc finger protein 286A - Homo sapiens (Human) - ZNF286A gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000176.1.512 Q9P2J8 ZN624_HUMAN 88.679 0.997644 0.981503 ZNF624 - Zinc finger protein 624 - Homo sapiens (Human) - ZNF624 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000176.1.513 Q9HBT7 ZN287_HUMAN 86.501 0.997361 0.996058 ZNF287 - Zinc finger protein 287 - Homo sapiens (Human) - ZNF287 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000176.1.514 Q8NAA5 LR75A_HUMAN 77.363 0.995025 1.1686 LRRC75A - Leucine-rich repeat-containing protein 75A - Homo sapiens (Human) - LRRC75A gene cytoplasm Taurus_UMD|evm.model.AC_000176.1.515 Q9WTR1 TRPV2_MOUSE 77.064 0.997347 0.997354 Trpv2 - Transient receptor potential cation channel subfamily V member 2 - Mus musculus (Mouse) - Trpv2 gene Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Taurus_UMD|evm.model.AC_000176.1.516 P0CG53 UBB_BOVIN 100.000 0.993464 1.00328 UBB - Polyubiquitin-B precursor - Bos taurus (Bovine) - UBB gene Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Taurus_UMD|evm.model.AC_000176.1.517 P84089 ERH_MOUSE 78.846 0.902655 1.08654 Erh - Enhancer of rudimentary homolog - Mus musculus (Mouse) - Erh gene May have a role in the cell cycle. Taurus_UMD|evm.model.AC_000176.1.518 Q9CXS4 CENPV_MOUSE 96.324 0.89404 0.599206 Cenpv - Centromere protein V - Mus musculus (Mouse) - Cenpv gene Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis. Taurus_UMD|evm.model.AC_000176.1.519 A6QQ24 PIGL_BOVIN 100.000 0.992126 1.00395 PIGL - N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase - Bos taurus (Bovine) - PIGL gene Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol (By similarity). Taurus_UMD|evm.model.AC_000176.1.520 O75376 NCOR1_HUMAN 89.959 0.999185 1.00574 NCOR1 - Nuclear receptor corepressor 1 - Homo sapiens (Human) - NCOR1 gene Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). Taurus_UMD|evm.model.AC_000176.1.521 Q6DKK2 TTC19_HUMAN 67.200 0.993994 0.876316 TTC19 - Tetratricopeptide repeat protein 19, mitochondrial precursor - Homo sapiens (Human) - TTC19 gene Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1 (PubMed:21278747, PubMed:28673544). Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation of UQCRFS1 into the complex III and whose presence is detrimental for its catalytic activity (PubMed:28673544). Taurus_UMD|evm.model.AC_000176.1.522 Q9CWQ2 ZSWM7_MOUSE 86.154 0.883562 0.960526 Zswim7 - Zinc finger SWIM domain-containing protein 7 - Mus musculus (Mouse) - Zswim7 gene Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Taurus_UMD|evm.model.AC_000176.1.523 Q1LZD0 AA2BR_BOVIN 91.209 0.994521 1.0994 ADORA2B - Adenosine receptor A2b - Bos taurus (Bovine) - ADORA2B gene Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Taurus_UMD|evm.model.AC_000176.1.524 Q5M775 CYTSB_HUMAN 79.888 0.978723 1.01217 SPECC1 - Cytospin-B - Homo sapiens (Human) - SPECC1 gene cytosol, fibrillar center, filamentous actin, intracellular membrane-bounded organelle, microtubule organizing center, nucleoplasm, actin cytoskeleton organization Taurus_UMD|evm.model.AC_000176.1.525 O43572 AKA10_HUMAN 92.296 0.996951 0.990937 AKAP10 - A-kinase anchor protein 10, mitochondrial precursor - Homo sapiens (Human) - AKAP10 gene Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). Taurus_UMD|evm.model.AC_000176.1.526 Q8IYT8 ULK2_HUMAN 89.768 0.998071 1.00097 ULK2 - Serine/threonine-protein kinase ULK2 - Homo sapiens (Human) - ULK2 gene Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. Taurus_UMD|evm.model.AC_000176.1.527 P30838 AL3A1_HUMAN 87.333 0.420806 2.35541 ALDH3A1 - Aldehyde dehydrogenase, dimeric NADP-preferring - Homo sapiens (Human) - ALDH3A1 gene ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). Taurus_UMD|evm.model.AC_000176.1.528 P51648 AL3A2_HUMAN 85.655 0.950495 1.04124 ALDH3A2 - Aldehyde dehydrogenase family 3 member A2 - Homo sapiens (Human) - ALDH3A2 gene Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:9133646, PubMed:22633490, PubMed:25047030, PubMed:18035827, PubMed:9662422, PubMed:18182499). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490). Taurus_UMD|evm.model.AC_000176.1.529 Q96FL8 S47A1_HUMAN 76.895 0.738356 1.2807 SLC47A1 - Multidrug and toxin extrusion protein 1 - Homo sapiens (Human) - SLC47A1 gene Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. Taurus_UMD|evm.model.AC_000176.1.530 Q08DF2 RN112_BOVIN 99.733 0.638699 0.929936 RNF112 - RING finger protein 112 - Bos taurus (Bovine) - RNF112 gene E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density. Taurus_UMD|evm.model.AC_000176.1.531 P55918 MFAP4_BOVIN 100.000 0.992188 1.00392 MFAP4 - Microfibril-associated glycoprotein 4 precursor - Bos taurus (Bovine) - MFAP4 gene Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance. Taurus_UMD|evm.model.AC_000176.1.532 A5PKJ4 MK07_BOVIN 100.000 0.997442 1.00128 MAPK7 - Mitogen-activated protein kinase 7 - Bos taurus (Bovine) - MAPK7 gene Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity). Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity). Taurus_UMD|evm.model.AC_000176.1.533 Q9UPM9 B9D1_HUMAN 94.608 0.990244 1.0049 B9D1 - B9 domain-containing protein 1 - Homo sapiens (Human) - B9D1 gene Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). Taurus_UMD|evm.model.AC_000176.1.534 Q9Z1Z3 EPN2_RAT 81.987 0.996604 1.01029 Epn2 - Epsin-2 - Rattus norvegicus (Rat) - Epn2 gene Plays a role in the formation of clathrin-coated invaginations and endocytosis. Taurus_UMD|evm.model.AC_000176.1.535 A6QLK6 GRAP_BOVIN 100.000 0.990826 1.00461 GRAP - GRB2-related adapter protein - Bos taurus (Bovine) - GRAP gene Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing. Taurus_UMD|evm.model.AC_000176.1.536 Q6R4Q5 SC5AA_BOVIN 100.000 0.927336 0.484087 SLC5A10 - Sodium/glucose cotransporter 5 - Bos taurus (Bovine) - SLC5A10 gene High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose. Taurus_UMD|evm.model.AC_000176.1.537 A6ND36 FA83G_HUMAN 80.120 0.997555 0.993925 FAM83G - Protein FAM83G - Homo sapiens (Human) - FAM83G gene May regulate the bone morphogenetic proteins (BMP) pathway. Taurus_UMD|evm.model.AC_000176.1.538 Q6R4Q5 SC5AA_BOVIN 100.000 0.946309 0.499162 SLC5A10 - Sodium/glucose cotransporter 5 - Bos taurus (Bovine) - SLC5A10 gene High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose. Taurus_UMD|evm.model.AC_000176.1.539 A2VDS0 KPRB_BOVIN 100.000 0.851852 1.17073 PRPSAP2 - Phosphoribosyl pyrophosphate synthase-associated protein 2 - Bos taurus (Bovine) - PRPSAP2 gene Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis. Taurus_UMD|evm.model.AC_000176.1.540 Q5E9P9 GLYC_BOVIN 95.021 0.830156 1.19215 SHMT1 - Serine hydroxymethyltransferase, cytosolic - Bos taurus (Bovine) - SHMT1 gene Interconversion of serine and glycine. Taurus_UMD|evm.model.AC_000176.1.541 Q8TEV9 SMCR8_HUMAN 82.157 0.996086 0.545358 SMCR8 - Guanine nucleotide exchange protein SMCR8 - Homo sapiens (Human) - SMCR8 gene Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27193190, PubMed:27103069, PubMed:27559131, PubMed:27617292, PubMed:28195531). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). Taurus_UMD|evm.model.AC_000176.1.542 Q8TEV9 SMCR8_HUMAN 94.203 0.86 0.426894 SMCR8 - Guanine nucleotide exchange protein SMCR8 - Homo sapiens (Human) - SMCR8 gene Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27193190, PubMed:27103069, PubMed:27559131, PubMed:27617292, PubMed:28195531). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). Taurus_UMD|evm.model.AC_000176.1.543 Q13472 TOP3A_HUMAN 85.274 0.998006 1.002 TOP3A - DNA topoisomerase 3-alpha - Homo sapiens (Human) - TOP3A gene Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. As an essential component of the RMI complex it is involved in chromosome separation and the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity (PubMed:30057030). It is required for mtDNA decatenation and segregation after completion of replication, in a process that does not require BLM, RMI1 and RMI2 (PubMed:29290614). Taurus_UMD|evm.model.AC_000176.1.544 Q96C03 MID49_HUMAN 80.088 0.970149 1.03304 MIEF2 - Mitochondrial dynamics protein MID49 - Homo sapiens (Human) - MIEF2 gene Mitochondrial outer membrane protein which regulates mitochondrial organization (PubMed:29361167). It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity. Taurus_UMD|evm.model.AC_000176.1.545 Q13045 FLII_HUMAN 95.073 0.998384 0.975571 FLII - Protein flightless-1 homolog - Homo sapiens (Human) - FLII gene May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. Taurus_UMD|evm.model.AC_000176.1.546 Q15334 L2GL1_HUMAN 90.602 0.998119 0.99906 LLGL1 - Lethal(2) giant larvae protein homolog 1 - Homo sapiens (Human) - LLGL1 gene Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. Taurus_UMD|evm.model.AC_000176.1.547 E1BH29 ALKB5_BOVIN 100.000 0.994937 1.00254 ALKBH5 - RNA demethylase ALKBH5 - Bos taurus (Bovine) - ALKBH5 gene Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (By similarity). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Taurus_UMD|evm.model.AC_000176.1.549 Q9UKN7 MYO15_HUMAN 81.255 0.993723 0.992918 MYO15A - Unconventional myosin-XV - Homo sapiens (Human) - MYO15A gene Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity). Taurus_UMD|evm.model.AC_000176.1.550 Q58D56 DRG2_BOVIN 100.000 0.994521 1.00275 DRG2 - Developmentally-regulated GTP-binding protein 2 - Bos taurus (Bovine) - DRG2 gene Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. Taurus_UMD|evm.model.AC_000176.1.551 Q8IVV7 GID4_HUMAN 99.078 0.990826 0.726667 GID4 - Glucose-induced degradation protein 4 homolog - Homo sapiens (Human) - GID4 gene Substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (Probable) (PubMed:29911972). Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly-Leu-Trp (PubMed:29632410). Binds peptides with an N-terminal sequence of the type Pro-[Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind peptides with an acetylated N-terminal Pro residue (PubMed:29632410). Taurus_UMD|evm.model.AC_000176.1.552 Q1LZ96 ATPF2_BOVIN 100.000 0.993103 1.00346 ATPAF2 - ATP synthase mitochondrial F1 complex assembly factor 2 precursor - Bos taurus (Bovine) - ATPAF2 gene May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase). Taurus_UMD|evm.model.AC_000176.1.553 Q9H069 DRC3_HUMAN 82.103 0.985428 1.04971 DRC3 - Dynein regulatory complex subunit 3 - Homo sapiens (Human) - DRC3 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Taurus_UMD|evm.model.AC_000176.1.554 Q6ZVM7 TM1L2_HUMAN 90.138 0.996 0.986193 TOM1L2 - TOM1-like protein 2 - Homo sapiens (Human) - TOM1L2 gene Probable role in protein transport. May regulate growth factor-induced mitogenic signaling. Taurus_UMD|evm.model.AC_000176.1.555 O97676 SRBP1_PIG 86.904 0.998256 0.996525 SREBF1 - Sterol regulatory element-binding protein 1 - Sus scrofa (Pig) - SREBF1 gene Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (By similarity). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity). Taurus_UMD|evm.model.AC_000176.1.556 Q7Z5J4 RAI1_HUMAN 85.752 0.998409 0.989507 RAI1 - Retinoic acid-induced protein 1 - Homo sapiens (Human) - RAI1 gene Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. Taurus_UMD|evm.model.AC_000176.1.557 Q9UBM1 PEMT_HUMAN 79.070 0.148936 1.41709 PEMT - Phosphatidylethanolamine N-methyltransferase - Homo sapiens (Human) - PEMT gene Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC). Taurus_UMD|evm.model.AC_000176.1.558 O35626 RASD1_MOUSE 86.071 0.99278 0.989286 Rasd1 - Dexamethasone-induced Ras-related protein 1 precursor - Mus musculus (Mouse) - Rasd1 gene Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity). Taurus_UMD|evm.model.AC_000176.1.559 Q2KHX9 MED9_BOVIN 99.310 0.986301 1.0069 MED9 - Mediator of RNA polymerase II transcription subunit 9 - Bos taurus (Bovine) - MED9 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Taurus_UMD|evm.model.AC_000176.1.560 Q9NPB1 NT5M_HUMAN 85.022 0.986726 0.991228 NT5M - 5'(3')-deoxyribonucleotidase, mitochondrial precursor - Homo sapiens (Human) - NT5M gene Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. Taurus_UMD|evm.model.AC_000176.1.561 A6H7B5 CSN3_BOVIN 100.000 0.995283 1.00236 COPS3 - COP9 signalosome complex subunit 3 - Bos taurus (Bovine) - COPS3 gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo (By similarity). Taurus_UMD|evm.model.AC_000176.1.562 Q3B7L5 FLCN_BOVIN 100.000 0.996552 1.00173 FLCN - Folliculin - Bos taurus (Bovine) - FLCN gene GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3. Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RRAGC/RagC or RRAGD/RagD, promoting the conversion to the GDP-bound state of RRAGC/RagC or RRAGD/RagD, and thereby activating the kinase activity of mTORC1. The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients. Acts as a key component for mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1. In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3. Upon amino acid restimulation, RRAGA/RagA (or RRAGB/RagB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3. Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3. Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (By similarity). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation. Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy. Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (By similarity). Taurus_UMD|evm.model.AC_000176.1.563 E1BE10 PLD6_BOVIN 100.000 0.99095 1.00455 PLD6 - Mitochondrial cardiolipin hydrolase - Bos taurus (Bovine) - PLD6 gene Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low. In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Also acts as a regulator of mitochondrial shape through facilitating mitochondrial fusion (By similarity). Taurus_UMD|evm.model.AC_000176.1.566 Q6WCQ1 MPRIP_HUMAN 92.965 0.942993 0.410732 MPRIP - Myosin phosphatase Rho-interacting protein - Homo sapiens (Human) - MPRIP gene Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. Taurus_UMD|evm.model.AC_000176.1.567 Q6WCQ1 MPRIP_HUMAN 92.580 0.386555 0.696585 MPRIP - Myosin phosphatase Rho-interacting protein - Homo sapiens (Human) - MPRIP gene Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. Taurus_UMD|evm.model.AC_000176.1.568 O14836 TR13B_HUMAN 61.463 0.871795 0.798635 TNFRSF13B - Tumor necrosis factor receptor superfamily member 13B - Homo sapiens (Human) - TNFRSF13B gene Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. Taurus_UMD|evm.model.AC_000176.1.569 P0C8Z3 UBP22_BOVIN 100.000 0.996117 1.00195 USP22 - Ubiquitin carboxyl-terminal hydrolase 22 - Bos taurus (Bovine) - USP22 gene Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression (By similarity). Taurus_UMD|evm.model.AC_000176.1.570 Q9R0U0 SRS10_MOUSE 98.855 0.992395 1.00382 Srsf10 - Serine/arginine-rich splicing factor 10 - Mus musculus (Mouse) - Srsf10 gene Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (By similarity). May be involved in regulation of alternative splicing in neurons (PubMed:10583508). Taurus_UMD|evm.model.AC_000176.1.571 P24049 RL17_RAT 86.555 0.682081 0.940217 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000176.1.572 Q3T0R4 DRS7B_BOVIN 99.686 0.924198 1.05538 DHRS7B - Dehydrogenase/reductase SDR family member 7B - Bos taurus (Bovine) - DHRS7B gene Putative oxidoreductase. Taurus_UMD|evm.model.AC_000176.1.573 A5D7N3 TMM11_BOVIN 100.000 0.989637 1.00521 TMEM11 - Transmembrane protein 11, mitochondrial - Bos taurus (Bovine) - TMEM11 gene Plays a role in mitochondrial morphogenesis. Taurus_UMD|evm.model.AC_000176.1.575 A6QL79 NATD1_BOVIN 100.000 0.982456 1.00885 NATD1 - Protein NATD1 - Bos taurus (Bovine) - NATD1 gene Taurus_UMD|evm.model.AC_000176.1.576 P46734 MP2K3_HUMAN 96.542 0.994253 1.00288 MAP2K3 - Dual specificity mitogen-activated protein kinase kinase 3 - Homo sapiens (Human) - MAP2K3 gene Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Taurus_UMD|evm.model.AC_000176.1.577 O19110 TSPY1_BOVIN 73.529 0.914286 0.44164 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000176.1.578 Q4TZY1 KCJ12_BOVIN 99.766 0.995327 1.00234 KCNJ12 - ATP-sensitive inward rectifier potassium channel 12 - Bos taurus (Bovine) - KCNJ12 gene Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity). Taurus_UMD|evm.model.AC_000176.1.579 A8PUI7 SKA3_BOVIN 81.579 0.381313 0.98263 SKA3 - Spindle and kinetochore-associated protein 3 - Bos taurus (Bovine) - SKA3 gene Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. Taurus_UMD|evm.model.AC_000176.1.580 Q9Y5J1 UTP18_HUMAN 85.432 0.966372 1.01619 UTP18 - U3 small nucleolar RNA-associated protein 18 homolog - Homo sapiens (Human) - UTP18 gene Involved in nucleolar processing of pre-18S ribosomal RNA. Taurus_UMD|evm.model.AC_000176.1.581 Q05BQ5 MBTD1_HUMAN 98.089 0.99682 1.00159 MBTD1 - MBT domain-containing protein 1 - Homo sapiens (Human) - MBTD1 gene Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. Taurus_UMD|evm.model.AC_000176.1.582 Q3T0Q4 NDKB_BOVIN 100.000 0.982609 0.756579 NME2 - Nucleoside diphosphate kinase B - Bos taurus (Bovine) - NME2 gene Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (By similarity). Exhibits histidine protein kinase activity (PubMed:12486123). Taurus_UMD|evm.model.AC_000176.1.583 P52174 NDKA1_BOVIN 99.091 0.947826 0.756579 NME1-1 - Nucleoside diphosphate kinase A 1 - Bos taurus (Bovine) - NME1-1 gene Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. Taurus_UMD|evm.model.AC_000176.1.584 P52175 NDKA2_BOVIN 97.727 0.589041 0.480263 NME1-2 - Nucleoside diphosphate kinase A 2 - Bos taurus (Bovine) - NME1-2 gene Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. Taurus_UMD|evm.model.AC_000176.1.585 O60271 JIP4_HUMAN 94.453 0.998486 1 SPAG9 - C-Jun-amino-terminal kinase-interacting protein 4 - Homo sapiens (Human) - SPAG9 gene The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). Taurus_UMD|evm.model.AC_000176.1.586 P50616 TOB1_HUMAN 97.681 0.994152 0.991304 TOB1 - Protein Tob1 - Homo sapiens (Human) - TOB1 gene Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257). Taurus_UMD|evm.model.AC_000176.1.587 Q08E66 WFKN2_BOVIN 99.826 0.996522 1.00174 WFIKKN2 - WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 precursor - Bos taurus (Bovine) - WFIKKN2 gene Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity). Taurus_UMD|evm.model.AC_000176.1.588 Q53H64 AK40L_HUMAN 83.168 0.684932 1.2807 ANKRD40CL - Putative ANKRD40 C-terminal-like protein - Homo sapiens (Human) - ANKRD40CL gene Taurus_UMD|evm.model.AC_000176.1.589 Q3SX41 LC7L3_BOVIN 100.000 0.863821 1.13889 LUC7L3 - Luc7-like protein 3 - Bos taurus (Bovine) - LUC7L3 gene Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity). Taurus_UMD|evm.model.AC_000176.1.590 Q6AI12 ANR40_HUMAN 95.380 0.994536 0.994565 ANKRD40 - Ankyrin repeat domain-containing protein 40 - Homo sapiens (Human) - ANKRD40 gene Taurus_UMD|evm.model.AC_000176.1.591 O15438 MRP3_HUMAN 84.892 0.998693 1.00196 ABCC3 - ATP-binding cassette sub-family C member 3 - Homo sapiens (Human) - ABCC3 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813). Taurus_UMD|evm.model.AC_000176.1.592 O43497 CAC1G_HUMAN 95.559 0.834722 0.959613 CACNA1G - Voltage-dependent T-type calcium channel subunit alpha-1G - Homo sapiens (Human) - CACNA1G gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Taurus_UMD|evm.model.AC_000176.1.593 Q8TB22 SPT20_HUMAN 93.020 0.996203 1.00509 SPATA20 - Spermatogenesis-associated protein 20 precursor - Homo sapiens (Human) - SPATA20 gene May play a role in fertility regulation. Taurus_UMD|evm.model.AC_000176.1.594 Q9H201 EPN3_HUMAN 82.453 0.996855 1.00633 EPN3 - Epsin-3 - Homo sapiens (Human) - EPN3 gene clathrin vesicle coat, clathrin-coated vesicle, endosome, extracellular exosome, extrinsic component of plasma membrane, intracellular membrane-bounded organelle, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane Taurus_UMD|evm.model.AC_000176.1.595 Q8TBZ2 MYBPP_HUMAN 75.322 0.982049 1 MYCBPAP - MYCBP-associated protein - Homo sapiens (Human) - MYCBPAP gene May play a role in spermatogenesis. May be involved in synaptic processes (By similarity). Taurus_UMD|evm.model.AC_000176.1.596 A5D7B1 RSAD1_BOVIN 99.548 0.995485 1.00226 RSAD1 - Radical S-adenosyl methionine domain-containing protein 1, mitochondrial precursor - Bos taurus (Bovine) - RSAD1 gene May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity). Taurus_UMD|evm.model.AC_000176.1.597 Q17QJ1 ACSF2_BOVIN 100.000 0.878151 0.386992 ACSF2 - Medium-chain acyl-CoA ligase ACSF2, mitochondrial precursor - Bos taurus (Bovine) - ACSF2 gene Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation. Taurus_UMD|evm.model.AC_000176.1.598 Q27972 CHAD_BOVIN 99.446 0.994475 1.00277 CHAD - Chondroadherin precursor - Bos taurus (Bovine) - CHAD gene Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation. Taurus_UMD|evm.model.AC_000176.1.599 Q17QJ1 ACSF2_BOVIN 90.580 0.962687 0.653659 ACSF2 - Medium-chain acyl-CoA ligase ACSF2, mitochondrial precursor - Bos taurus (Bovine) - ACSF2 gene Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation. Taurus_UMD|evm.model.AC_000176.1.600 Q5E9X4 LRC59_BOVIN 100.000 0.993485 1.00327 LRRC59 - Leucine-rich repeat-containing protein 59 - Bos taurus (Bovine) - LRRC59 gene Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity). Taurus_UMD|evm.model.AC_000176.1.601 Q5NVA9 EME1_PONAB 73.322 0.996522 1 EME1 - Crossover junction endonuclease EME1 - Pongo abelii (Sumatran orangutan) - EME1 gene Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity). Taurus_UMD|evm.model.AC_000176.1.602 Q32PC3 RM27_BOVIN 100.000 0.986577 1.00676 MRPL27 - 39S ribosomal protein L27, mitochondrial precursor - Bos taurus (Bovine) - MRPL27 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000176.1.603 Q5QQ50 XYLT2_CANLF 95.376 0.997688 1 XYLT2 - Xylosyltransferase 2 - Canis lupus familiaris (Dog) - XYLT2 gene Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN (By similarity). Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (By similarity). Taurus_UMD|evm.model.AC_000176.1.604 Q6UXU6 TMM92_HUMAN 56.707 0.416 2.35849 TMEM92 - Transmembrane protein 92 precursor - Homo sapiens (Human) - TMEM92 gene nucleoplasm Taurus_UMD|evm.model.AC_000176.1.605 Q5R893 H2B1_PONAB 93.651 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000176.1.606 P02453 CO1A1_BOVIN 97.744 0.998602 0.978127 COL1A1 - Collagen alpha-1(I) chain precursor - Bos taurus (Bovine) - COL1A1 gene Type I collagen is a member of group I collagen (fibrillar forming collagen). Taurus_UMD|evm.model.AC_000176.1.607 Q16586 SGCA_HUMAN 88.660 0.994859 1.00517 SGCA - Alpha-sarcoglycan precursor - Homo sapiens (Human) - SGCA gene Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Taurus_UMD|evm.model.AC_000176.1.608 Q8IZD0 SAM14_HUMAN 95.923 0.398086 2.506 SAMD14 - Sterile alpha motif domain-containing protein 14 - Homo sapiens (Human) - SAMD14 gene actin cytoskeleton, cytoplasm, dendrite, postsynaptic density, actin filament binding, actin filament organization, calcium-mediated signaling, neuron projection development Taurus_UMD|evm.model.AC_000176.1.609 Q15119 PDK2_HUMAN 98.034 0.995098 1.00246 PDK2 - [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial precursor - Homo sapiens (Human) - PDK2 gene Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. Taurus_UMD|evm.model.AC_000176.1.610 Q61739 ITA6_MOUSE 44.231 0.731343 0.0614115 Itga6 - Integrin alpha-6 precursor - Mus musculus (Mouse) - Itga6 gene Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (PubMed:8081870). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (PubMed:10634791). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (PubMed:8673141). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (By similarity). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity). Taurus_UMD|evm.model.AC_000176.1.611 F1MMS9 ITA3_BOVIN 100.000 0.998097 1.00095 ITGA3 - Integrin alpha-3 precursor - Bos taurus (Bovine) - ITGA3 gene Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Taurus_UMD|evm.model.AC_000176.1.612 O60479 DLX3_HUMAN 99.303 0.993056 1.00348 DLX3 - Homeobox protein DLX-3 - Homo sapiens (Human) - DLX3 gene Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. Taurus_UMD|evm.model.AC_000176.1.613 Q92988 DLX4_HUMAN 83.750 0.991489 0.979167 DLX4 - Homeobox protein DLX-4 - Homo sapiens (Human) - DLX4 gene May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis. Taurus_UMD|evm.model.AC_000176.1.615 Q6ECK6 TKN4_RABIT 61.644 0.614035 1.14 TAC4 - Tachykinin-4 precursor - Oryctolagus cuniculus (Rabbit) - TAC4 gene Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Taurus_UMD|evm.model.AC_000176.1.616 O95251 KAT7_HUMAN 99.673 0.996732 1.00164 KAT7 - Histone acetyltransferase KAT7 - Homo sapiens (Human) - KAT7 gene Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). Taurus_UMD|evm.model.AC_000176.1.617 Q9C073 F117A_HUMAN 92.971 0.969163 1.00221 FAM117A - Protein FAM117A - Homo sapiens (Human) - FAM117A gene Taurus_UMD|evm.model.AC_000176.1.618 Q8MII5 S35B1_BOVIN 100.000 0.901685 1.10559 SLC35B1 - Solute carrier family 35 member B1 - Bos taurus (Bovine) - SLC35B1 gene Probable sugar transporter. Taurus_UMD|evm.model.AC_000176.1.619 Q5NVK7 SPOP_PONAB 100.000 0.994667 1.00267 SPOP - Speckle-type POZ protein - Pongo abelii (Sumatran orangutan) - SPOP gene Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Involved in the regulation of bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4 stability. Taurus_UMD|evm.model.AC_000176.1.620 O95157 NXPH3_HUMAN 94.118 0.852518 1.10317 NXPH3 - Neurexophilin-3 precursor - Homo sapiens (Human) - NXPH3 gene May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity). Taurus_UMD|evm.model.AC_000176.1.621 P08138 TNR16_HUMAN 95.571 0.995349 1.00703 NGFR - Tumor necrosis factor receptor superfamily member 16 precursor - Homo sapiens (Human) - NGFR gene Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). Taurus_UMD|evm.model.AC_000176.1.622 P35232 PHB_HUMAN 100.000 0.992674 1.00368 PHB - Prohibitin - Homo sapiens (Human) - PHB gene Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity). Taurus_UMD|evm.model.AC_000176.1.623 Q9Y2D9 ZN652_HUMAN 96.382 0.996716 1.00495 ZNF652 - Zinc finger protein 652 - Homo sapiens (Human) - ZNF652 gene Functions as a transcriptional repressor. Taurus_UMD|evm.model.AC_000176.1.625 Q8TCT1 PHOP1_HUMAN 90.769 0.739255 1.30712 PHOSPHO1 - Phosphoethanolamine/phosphocholine phosphatase - Homo sapiens (Human) - PHOSPHO1 gene Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. Taurus_UMD|evm.model.AC_000176.1.626 Q9P2A4 ABI3_HUMAN 82.466 0.988889 0.983607 ABI3 - ABI gene family member 3 - Homo sapiens (Human) - ABI3 gene May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility. Taurus_UMD|evm.model.AC_000176.1.627 P50154 GBGT2_BOVIN 100.000 0.971429 1.01449 GNGT2 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 precursor - Bos taurus (Bovine) - GNGT2 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Taurus_UMD|evm.model.AC_000176.1.629 Q8NHY0 B4GN2_HUMAN 83.885 0.993407 0.803887 B4GALNT2 - Beta-1,4 N-acetylgalactosaminyltransferase 2 - Homo sapiens (Human) - B4GALNT2 gene Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain. Taurus_UMD|evm.model.AC_000176.1.630 Q9NZI8 IF2B1_HUMAN 97.054 0.996491 0.987868 IGF2BP1 - Insulin-like growth factor 2 mRNA-binding protein 1 - Homo sapiens (Human) - IGF2BP1 gene RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts. Taurus_UMD|evm.model.AC_000176.1.631 P09680 GIP_BOVIN 100.000 0.230337 4.2381 GIP - Gastric inhibitory polypeptide - Bos taurus (Bovine) - GIP gene Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. Taurus_UMD|evm.model.AC_000176.1.632 Q96H20 SNF8_HUMAN 99.225 0.992278 1.00388 SNF8 - Vacuolar-sorting protein SNF8 - Homo sapiens (Human) - SNF8 gene Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Taurus_UMD|evm.model.AC_000176.1.633 Q3B7D1 UBE2Z_RAT 99.438 0.994398 1.00281 Ube2z - Ubiquitin-conjugating enzyme E2 Z - Rattus norvegicus (Rat) - Ube2z gene Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation. Taurus_UMD|evm.model.AC_000176.1.634 P32876 AT5G1_BOVIN 100.000 0.985401 1.00735 ATP5MC1 - ATP synthase F(0) complex subunit C1, mitochondrial precursor - Bos taurus (Bovine) - ATP5MC1 gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element. Taurus_UMD|evm.model.AC_000176.1.635 O18737 CACO2_BOVIN 100.000 0.91446 1.09111 CALCOCO2 - Calcium-binding and coiled-coil domain-containing protein 2 - Bos taurus (Bovine) - CALCOCO2 gene Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (By similarity). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity). Taurus_UMD|evm.model.AC_000176.1.636 Q8N841 TTLL6_HUMAN 74.913 0.975141 1.04982 TTLL6 - Tubulin polyglutamylase TTLL6 - Homo sapiens (Human) - TTLL6 gene Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Generates long side-chains. Generates polyglutamylation of CGAS, leading to impair the DNA-binding activity of CGAS. Taurus_UMD|evm.model.AC_000176.1.637 Q92826 HXB13_HUMAN 93.333 0.993007 1.00704 HOXB13 - Homeobox protein Hox-B13 - Homo sapiens (Human) - HOXB13 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536). Taurus_UMD|evm.model.AC_000176.1.638 P17482 HXB9_HUMAN 99.600 0.992032 1.004 HOXB9 - Homeobox protein Hox-B9 - Homo sapiens (Human) - HOXB9 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000176.1.639 P09632 HXB8_MOUSE 99.296 0.615721 0.942387 Hoxb8 - Homeobox protein Hox-B8 - Mus musculus (Mouse) - Hoxb8 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000176.1.640 Q9TT89 HXB7_BOVIN 97.696 0.990826 1.00461 HOXB7 - Homeobox protein Hox-B7 - Bos taurus (Bovine) - HOXB7 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000176.1.641 P09023 HXB6_MOUSE 97.842 0.978723 0.629464 Hoxb6 - Homeobox protein Hox-B6 - Mus musculus (Mouse) - Hoxb6 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000176.1.642 P09067 HXB5_HUMAN 98.387 0.908088 1.01115 HOXB5 - Homeobox protein Hox-B5 - Homo sapiens (Human) - HOXB5 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000176.1.643 Q08DG5 HXB4_BOVIN 96.016 0.991968 0.992032 HOXB4 - Homeobox protein Hox-B4 - Bos taurus (Bovine) - HOXB4 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000176.1.645 P14651 HXB3_HUMAN 93.968 0.995316 0.990719 HOXB3 - Homeobox protein Hox-B3 - Homo sapiens (Human) - HOXB3 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000176.1.646 P14652 HXB2_HUMAN 85.994 0.994366 0.997191 HOXB2 - Homeobox protein Hox-B2 - Homo sapiens (Human) - HOXB2 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Taurus_UMD|evm.model.AC_000176.1.647 A2T7J2 HXB1_PONPY 88.742 0.993399 1.00664 HOXB1 - Homeobox protein Hox-B1 - Pongo pygmaeus (Bornean orangutan) - HOXB1 gene Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures (By similarity). Taurus_UMD|evm.model.AC_000176.1.648 Q2HJ94 DNJA2_BOVIN 88.146 0.993846 0.788835 DNAJA2 - DnaJ homolog subfamily A member 2 precursor - Bos taurus (Bovine) - DNAJA2 gene Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Taurus_UMD|evm.model.AC_000176.1.650 Q86WV1 SKAP1_HUMAN 83.051 0.99435 0.986072 SKAP1 - Src kinase-associated phosphoprotein 1 - Homo sapiens (Human) - SKAP1 gene Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. Taurus_UMD|evm.model.AC_000176.1.652 Q08DD7 SNX11_BOVIN 100.000 0.99262 1.0037 SNX11 - Sorting nexin-11 - Bos taurus (Bovine) - SNX11 gene Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Taurus_UMD|evm.model.AC_000176.1.653 P83917 CBX1_MOUSE 100.000 0.836364 1.18919 Cbx1 - Chromobox protein homolog 1 - Mus musculus (Mouse) - Cbx1 gene Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Taurus_UMD|evm.model.AC_000176.1.655 A5D7E9 NF2L1_BOVIN 98.579 0.997419 1.01573 NFE2L1 - Endoplasmic reticulum membrane sensor NFE2L1 - Bos taurus (Bovine) - NFE2L1 gene Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (By similarity). Taurus_UMD|evm.model.AC_000176.1.656 Q9P299 COPZ2_HUMAN 93.750 0.638554 1.18571 COPZ2 - Coatomer subunit zeta-2 - Homo sapiens (Human) - COPZ2 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. Taurus_UMD|evm.model.AC_000176.1.657 Q96JB5 CK5P3_HUMAN 90.514 0.996047 1 CDK5RAP3 - CDK5 regulatory subunit-associated protein 3 - Homo sapiens (Human) - CDK5RAP3 gene Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress (PubMed:23152784, PubMed:30635284). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). Required for liver development (By similarity). Taurus_UMD|evm.model.AC_000176.1.658 Q3T183 PR15L_BOVIN 100.000 0.980198 1.01 PRR15L - Proline-rich protein 15-like protein - Bos taurus (Bovine) - PRR15L gene Taurus_UMD|evm.model.AC_000176.1.659 Q5E9K3 PNPO_BOVIN 100.000 0.992366 1.00383 PNPO - Pyridoxine-5'-phosphate oxidase - Bos taurus (Bovine) - PNPO gene Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). Taurus_UMD|evm.model.AC_000176.1.660 Q5E9U0 SP2_BOVIN 100.000 0.972843 1.02121 SP2 - Transcription factor Sp2 - Bos taurus (Bovine) - SP2 gene Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Taurus_UMD|evm.model.AC_000176.1.661 Q3SY56 SP6_HUMAN 96.011 0.994681 1 SP6 - Transcription factor Sp6 - Homo sapiens (Human) - SP6 gene Promotes cell proliferation. Taurus_UMD|evm.model.AC_000176.1.662 Q96FV2 SCRN2_HUMAN 87.348 0.962441 1.00235 SCRN2 - Secernin-2 - Homo sapiens (Human) - SCRN2 gene extracellular exosome Taurus_UMD|evm.model.AC_000176.1.663 Q96FV0 LRC46_HUMAN 79.630 0.993846 1.01246 LRRC46 - Leucine-rich repeat-containing protein 46 - Homo sapiens (Human) - LRRC46 gene Taurus_UMD|evm.model.AC_000176.1.664 Q3MHY7 RM10_BOVIN 100.000 0.992395 1.00382 MRPL10 - 39S ribosomal protein L10, mitochondrial precursor - Bos taurus (Bovine) - MRPL10 gene large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, ribonucleoprotein complex, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000176.1.665 Q9BZF2 OSBL7_HUMAN 92.874 0.997613 0.995249 OSBPL7 - Oxysterol-binding protein-related protein 7 - Homo sapiens (Human) - OSBPL7 gene autophagosome, cytosol, intracellular membrane-bounded organelle, membrane, nucleoplasm, perinuclear endoplasmic reticulum, plasma membrane, cholesterol binding, sterol binding, sterol transporter activity Taurus_UMD|evm.model.AC_000176.1.667 Q9UL17 TBX21_HUMAN 90.093 0.996248 0.996262 TBX21 - T-box transcription factor TBX21 - Homo sapiens (Human) - TBX21 gene Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931). Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648). Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC. Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2. Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN-stimulated genes. Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (By similarity). Taurus_UMD|evm.model.AC_000176.1.668 Q14974 IMB1_HUMAN 99.429 0.567813 1.75913 KPNB1 - Importin subunit beta-1 - Homo sapiens (Human) - KPNB1 gene Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus. Taurus_UMD|evm.model.AC_000176.1.669 P30050 RL12_HUMAN 65.278 0.592391 1.11515 RPL12 - 60S ribosomal protein L12 - Homo sapiens (Human) - RPL12 gene Binds directly to 26S ribosomal RNA. Taurus_UMD|evm.model.AC_000176.1.670 P55786 PSA_HUMAN 98.441 0.96748 0.936888 NPEPPS - Puromycin-sensitive aminopeptidase - Homo sapiens (Human) - NPEPPS gene Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. Taurus_UMD|evm.model.AC_000176.1.671 Q3T142 RM45_BOVIN 99.346 0.993485 1.00327 MRPL45 - 39S ribosomal protein L45, mitochondrial precursor - Bos taurus (Bovine) - MRPL45 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Taurus_UMD|evm.model.AC_000176.1.672 Q6PRD1 GP179_HUMAN 72.636 0.982874 1.01141 GPR179 - Probable G-protein coupled receptor 179 precursor - Homo sapiens (Human) - GPR179 gene Orphan receptor, involved in vision. Required for signal transduction through retinal depolarizing bipolar cells. Taurus_UMD|evm.model.AC_000176.1.673 O14512 SOCS7_HUMAN 97.251 0.897356 1.10671 SOCS7 - Suppressor of cytokine signaling 7 - Homo sapiens (Human) - SOCS7 gene Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Taurus_UMD|evm.model.AC_000176.1.674 Q9P227 RHG23_HUMAN 93.908 0.945874 0.755869 ARHGAP23 - Rho GTPase-activating protein 23 - Homo sapiens (Human) - ARHGAP23 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000176.1.675 Q9P227 RHG23_HUMAN 92.661 0.981818 0.073776 ARHGAP23 - Rho GTPase-activating protein 23 - Homo sapiens (Human) - ARHGAP23 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000176.1.677 Q9C0H9 SRCN1_HUMAN 94.132 0.965517 1.0541 SRCIN1 - SRC kinase signaling inhibitor 1 - Homo sapiens (Human) - SRCIN1 gene Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. Taurus_UMD|evm.model.AC_000176.1.678 A6NHQ4 EPOP_HUMAN 81.217 0.992105 1.00264 EPOP - Elongin BC and Polycomb repressive complex 2-associated protein - Homo sapiens (Human) - EPOP gene Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation. Taurus_UMD|evm.model.AC_000176.1.679 P55198 AF17_HUMAN 96.624 0.998175 1.00274 MLLT6 - Protein AF-17 - Homo sapiens (Human) - MLLT6 gene nucleus, histone binding, nucleosome binding, positive regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated Taurus_UMD|evm.model.AC_000176.1.680 B1AR13 CISD3_MOUSE 84.348 0.890625 0.934307 Cisd3 - CDGSH iron-sulfur domain-containing protein 3, mitochondrial precursor - Mus musculus (Mouse) - Cisd3 gene Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function. Taurus_UMD|evm.model.AC_000176.1.681 P35227 PCGF2_HUMAN 96.512 0.994203 1.00291 PCGF2 - Polycomb group RING finger protein 2 - Homo sapiens (Human) - PCGF2 gene Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Taurus_UMD|evm.model.AC_000176.1.682 P33672 PSB3_BOVIN 100.000 0.990291 1.00488 PSMB3 - Proteasome subunit beta type-3 - Bos taurus (Bovine) - PSMB3 gene Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Taurus_UMD|evm.model.AC_000176.1.683 Q80XI4 PI42B_MOUSE 99.519 0.995204 1.0024 Pip4k2b - Phosphatidylinositol 5-phosphate 4-kinase type-2 beta - Mus musculus (Mouse) - Pip4k2b gene Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. In collaboration with PIP4K2A, has a role in mediating autophagy in times of nutrient stress (PubMed:29727621). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:29727621). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (By similarity). Taurus_UMD|evm.model.AC_000176.1.684 Q9NXE8 CWC25_HUMAN 93.412 0.995305 1.00235 CWC25 - Pre-mRNA-splicing factor CWC25 homolog - Homo sapiens (Human) - CWC25 gene Involved in pre-mRNA splicing as component of the spliceosome. Taurus_UMD|evm.model.AC_000176.1.685 A8MV24 CQ098_HUMAN 81.818 0.987097 1.00649 C17orf98 - Uncharacterized protein C17orf98 - Homo sapiens (Human) - C17orf98 gene Taurus_UMD|evm.model.AC_000176.1.686 P62832 RL23_RAT 100.000 0.985816 1.00714 Rpl23 - 60S ribosomal protein L23 - Rattus norvegicus (Rat) - Rpl23 gene cytoplasm, cytosolic large ribosomal subunit, nucleolus, nucleoplasm, postsynaptic density, protein-containing complex, ribosome, large ribosomal subunit rRNA binding, structural constituent of ribosome, transcription coactivator binding Taurus_UMD|evm.model.AC_000176.1.687 Q3B7M5 LASP1_BOVIN 100.000 0.992337 1.00385 LASP1 - LIM and SH3 domain protein 1 - Bos taurus (Bovine) - LASP1 gene Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). Taurus_UMD|evm.model.AC_000176.1.688 A2A6H3 FBX47_MOUSE 87.615 0.661585 0.727273 Fbxo47 - F-box only protein 47 - Mus musculus (Mouse) - Fbxo47 gene Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Taurus_UMD|evm.model.AC_000176.1.689 Q8IUK5 PLDX1_HUMAN 81.200 0.995585 0.906 PLXDC1 - Plexin domain-containing protein 1 precursor - Homo sapiens (Human) - PLXDC1 gene Plays a critical role in endothelial cell capillary morphogenesis. Taurus_UMD|evm.model.AC_000176.1.690 P19517 CACB1_RABIT 96.008 0.756369 1.19847 CACNB1 - Voltage-dependent L-type calcium channel subunit beta-1 - Oryctolagus cuniculus (Rabbit) - CACNB1 gene Regulatory subunit of L-type calcium channels (PubMed:7509046). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (PubMed:7509046). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (By similarity). Taurus_UMD|evm.model.AC_000176.1.691 A6NH57 ARL5C_HUMAN 66.906 0.947368 0.636872 ARL5C - Putative ADP-ribosylation factor-like protein 5C - Homo sapiens (Human) - ARL5C gene Binds and exchanges GTP and GDP. Taurus_UMD|evm.model.AC_000176.1.692 P84100 RL19_RAT 94.643 0.938202 0.908163 Rpl19 - 60S ribosomal protein L19 - Rattus norvegicus (Rat) - Rpl19 gene cytosolic large ribosomal subunit, polysomal ribosome, synapse, 5.8S rRNA binding, large ribosomal subunit rRNA binding, RNA binding, structural constituent of ribosome, cytoplasmic translation, liver regeneration Taurus_UMD|evm.model.AC_000176.1.693 Q8R1B0 STAC2_MOUSE 95.588 0.99511 1.00245 Stac2 - SH3 and cysteine-rich domain-containing protein 2 - Mus musculus (Mouse) - Stac2 gene Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity (PubMed:29467163). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:25548159, PubMed:29363593). Taurus_UMD|evm.model.AC_000176.1.694 Q7T2U9 TFCP2_CHICK 50.112 0.912281 0.919355 TFCP2 - Transcription factor CP2 - Gallus gallus (Chicken) - TFCP2 gene Binds the B-response element 5'-CAAGTCCAGGCAAGT-3' of the ENS1/ERNI promoter. May be the major transcription activator thus being essential for its expression. Taurus_UMD|evm.model.AC_000176.1.695 Q96IG2 FXL20_HUMAN 100.000 0.995423 1.00229 FBXL20 - F-box/LRR-repeat protein 20 - Homo sapiens (Human) - FBXL20 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). Taurus_UMD|evm.model.AC_000176.1.696 Q15648 MED1_HUMAN 97.217 0.998731 0.996837 MED1 - Mediator of RNA polymerase II transcription subunit 1 - Homo sapiens (Human) - MED1 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Taurus_UMD|evm.model.AC_000176.1.697 E1BB50 CDK12_BOVIN 99.602 0.991297 1 CDK12 - Cyclin-dependent kinase 12 - Bos taurus (Bovine) - CDK12 gene Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors (By similarity). Taurus_UMD|evm.model.AC_000176.1.699 Q7ZYS1 RL19_XENLA 54.348 0.949367 0.401015 rpl19 - 60S ribosomal protein L19 - Xenopus laevis (African clawed frog) - rpl19 gene Taurus_UMD|evm.model.AC_000176.1.700 Q15784 NDF2_HUMAN 97.644 0.994778 1.00262 NEUROD2 - Neurogenic differentiation factor 2 - Homo sapiens (Human) - NEUROD2 gene Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity). Taurus_UMD|evm.model.AC_000176.1.702 P07516 PPR1B_BOVIN 100.000 0.990148 1.00495 PPP1R1B - Protein phosphatase 1 regulatory subunit 1B - Bos taurus (Bovine) - PPP1R1B gene Inhibitor of protein-phosphatase 1. Taurus_UMD|evm.model.AC_000176.1.703 Q14849 STAR3_HUMAN 94.643 0.995546 1.00899 STARD3 - StAR-related lipid transfer protein 3 - Homo sapiens (Human) - STARD3 gene Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544). Taurus_UMD|evm.model.AC_000176.1.704 Q6T8D8 TELT_BOVIN 100.000 0.988024 1.00602 TCAP - Telethonin - Bos taurus (Bovine) - TCAP gene Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk (By similarity). Taurus_UMD|evm.model.AC_000176.1.705 P10938 PNMT_BOVIN 95.406 0.992958 1.00353 PNMT - Phenylethanolamine N-methyltransferase - Bos taurus (Bovine) - PNMT gene Converts noradrenaline to adrenaline. Taurus_UMD|evm.model.AC_000176.1.706 A7YWP2 PGAP3_BOVIN 100.000 0.99375 1.00313 PGAP3 - Post-GPI attachment to proteins factor 3 precursor - Bos taurus (Bovine) - PGAP3 gene Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (By similarity). Taurus_UMD|evm.model.AC_000176.1.707 O18735 ERBB2_CANLF 92.143 0.998404 0.995234 ERBB2 - Receptor tyrosine-protein kinase erbB-2 precursor - Canis lupus familiaris (Dog) - ERBB2 gene Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Taurus_UMD|evm.model.AC_000176.1.708 Q148C8 MIEN1_BOVIN 100.000 0.982759 1.0087 MIEN1 - Migration and invasion enhancer 1 precursor - Bos taurus (Bovine) - MIEN1 gene Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity). Taurus_UMD|evm.model.AC_000176.1.709 Q1RMW5 GRB7_BOVIN 100.000 0.996248 1.00188 GRB7 - Growth factor receptor-bound protein 7 - Bos taurus (Bovine) - GRB7 gene Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). Taurus_UMD|evm.model.AC_000176.1.710 A2VDW9 IKZF3_BOVIN 95.464 0.943359 1.00589 IKZF3 - Zinc finger protein Aiolos - Bos taurus (Bovine) - IKZF3 gene Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000176.1.711 Q6X784 ZPBP2_HUMAN 79.692 0.990826 0.967456 ZPBP2 - Zona pellucida-binding protein 2 precursor - Homo sapiens (Human) - ZPBP2 gene Is implicated in sperm-oocyte interaction during fertilization. Taurus_UMD|evm.model.AC_000176.1.712 Q8TAX9 GSDMB_HUMAN 50.667 0.995495 1.08029 GSDMB - Gasdermin-B - Homo sapiens (Human) - GSDMB gene Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death (PubMed:32299851). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-B, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:32299851). Taurus_UMD|evm.model.AC_000176.1.713 Q0VD15 ORML3_BOVIN 100.000 0.7343 1.35294 ORMDL3 - ORM1-like protein 3 - Bos taurus (Bovine) - ORMDL3 gene Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). Taurus_UMD|evm.model.AC_000176.1.714 A6NJW4 LRR3C_HUMAN 85.827 0.992157 0.927273 LRRC3C - Leucine-rich repeat-containing protein 3C precursor - Homo sapiens (Human) - LRRC3C gene extracellular matrix, extracellular space Taurus_UMD|evm.model.AC_000176.1.715 Q96QA5 GSDMA_HUMAN 89.013 0.995526 1.00449 GSDMA - Gasdermin-A - Homo sapiens (Human) - GSDMA gene This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-A, N-terminal) binds to membranes and forms pores, triggering cell death. Taurus_UMD|evm.model.AC_000176.1.716 Q2KJ46 PSMD3_BOVIN 100.000 0.996262 1.00187 PSMD3 - 26S proteasome non-ATPase regulatory subunit 3 - Bos taurus (Bovine) - PSMD3 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Taurus_UMD|evm.model.AC_000176.1.717 P35833 CSF3_BOVIN 100.000 0.989796 1.00513 CSF3 - Granulocyte colony-stimulating factor precursor - Bos taurus (Bovine) - CSF3 gene Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Taurus_UMD|evm.model.AC_000176.1.718 O75448 MED24_HUMAN 96.360 0.99798 1.00101 MED24 - Mediator of RNA polymerase II transcription subunit 24 - Homo sapiens (Human) - MED24 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Taurus_UMD|evm.model.AC_000176.1.719 Q28570 THA_SHEEP 100.000 0.995134 1.00244 THRA - Thyroid hormone receptor alpha - Ovis aries (Sheep) - THRA gene Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Taurus_UMD|evm.model.AC_000176.1.720 Q08E02 NR1D1_BOVIN 100.000 0.996743 1.00163 NR1D1 - Nuclear receptor subfamily 1 group D member 1 - Bos taurus (Bovine) - NR1D1 gene Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner (By similarity). Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity). Taurus_UMD|evm.model.AC_000176.1.721 Q68DK7 MSL1_HUMAN 99.023 0.996748 1.00163 MSL1 - Male-specific lethal 1 homolog - Homo sapiens (Human) - MSL1 gene Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Taurus_UMD|evm.model.AC_000176.1.722 A5D7H5 CASC3_BOVIN 100.000 0.997159 1.00142 CASC3 - Protein CASC3 - Bos taurus (Bovine) - CASC3 gene Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. Taurus_UMD|evm.model.AC_000176.1.723 Q5R9B2 RPGFL_PONPY 97.368 0.54491 1.83114 RAPGEFL1 - Rap guanine nucleotide exchange factor-like 1 - Pongo pygmaeus (Bornean orangutan) - RAPGEFL1 gene Probable guanine nucleotide exchange factor (GEF). Taurus_UMD|evm.model.AC_000176.1.724 Q8TF74 WIPF2_HUMAN 93.488 0.426295 2.28182 WIPF2 - WAS/WASL-interacting protein family member 2 - Homo sapiens (Human) - WIPF2 gene Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. Taurus_UMD|evm.model.AC_000176.1.725 P10276 RARA_HUMAN 99.567 0.99568 1.00216 RARA - Retinoic acid receptor alpha - Homo sapiens (Human) - RARA gene Receptor for retinoic acid (PubMed:19850744, PubMed:16417524, PubMed:20215566). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:28167758). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:9267036, PubMed:19850744, PubMed:20215566). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758). Taurus_UMD|evm.model.AC_000176.1.726 Q8N144 CXD3_HUMAN 79.333 0.992982 0.969388 GJD3 - Gap junction delta-3 protein - Homo sapiens (Human) - GJD3 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Taurus_UMD|evm.model.AC_000176.1.727 O46374 TOP2A_PIG 94.977 0.998695 1 TOP2A - DNA topoisomerase 2-alpha - Sus scrofa (Pig) - TOP2A gene Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (By similarity). May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity). Taurus_UMD|evm.model.AC_000176.1.728 Q05716 IBP4_BOVIN 100.000 0.992278 1.00388 IGFBP4 - Insulin-like growth factor-binding protein 4 precursor - Bos taurus (Bovine) - IGFBP4 gene IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Taurus_UMD|evm.model.AC_000176.1.729 Q32PJ7 TENS4_BOVIN 99.860 0.997211 1.0014 TNS4 - Tensin-4 precursor - Bos taurus (Bovine) - TNS4 gene May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton May promote apoptosis, via its cleavage by caspase-3. Cytoplasm, cytoskeleton. Taurus_UMD|evm.model.AC_000176.1.731 Q5MD62 CCR7_BOVIN 99.202 0.910194 1.08707 CCR7 - C-C chemokine receptor type 7 precursor - Bos taurus (Bovine) - CCR7 gene Receptor for the MIP-3-beta chemokine. Taurus_UMD|evm.model.AC_000176.1.732 Q969G3 SMCE1_HUMAN 96.594 0.995146 1.00243 SMARCE1 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 - Homo sapiens (Human) - SMARCE1 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. Taurus_UMD|evm.model.AC_000176.1.733 Q2KI75 KT222_BOVIN 100.000 0.993243 1.00339 KRT222 - Keratin-like protein KRT222 - Bos taurus (Bovine) - KRT222 gene Taurus_UMD|evm.model.AC_000176.1.734 Q2M2I5 K1C24_HUMAN 83.092 0.765799 1.02476 KRT24 - Keratin, type I cytoskeletal 24 - Homo sapiens (Human) - KRT24 gene cytosol, extracellular exosome, cornification, keratinization Taurus_UMD|evm.model.AC_000176.1.735 Q0P5J4 K1C25_BOVIN 100.000 0.995169 0.92 KRT25 - Keratin, type I cytoskeletal 25 - Bos taurus (Bovine) - KRT25 gene Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (By similarity). Taurus_UMD|evm.model.AC_000176.1.736 A6H712 K1C26_BOVIN 100.000 0.995745 1.00213 KRT26 - Keratin, type I cytoskeletal 26 - Bos taurus (Bovine) - KRT26 gene Taurus_UMD|evm.model.AC_000176.1.737 Q0P5J6 K1C27_BOVIN 96.739 0.995556 0.978261 KRT27 - Keratin, type I cytoskeletal 27 - Bos taurus (Bovine) - KRT27 gene Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). Taurus_UMD|evm.model.AC_000176.1.738 Q148H6 K1C28_BOVIN 100.000 0.464903 2.11853 KRT28 - Keratin, type I cytoskeletal 28 - Bos taurus (Bovine) - KRT28 gene Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs). Taurus_UMD|evm.model.AC_000176.1.739 Q28706 K1C12_RABIT 85.012 0.820202 1.20438 KRT12 - Keratin, type I cytoskeletal 12 - Oryctolagus cuniculus (Rabbit) - KRT12 gene Involved in corneal epithelium organization, integrity and corneal keratin expression. Taurus_UMD|evm.model.AC_000176.1.740 A6QQQ9 K1C20_BOVIN 95.699 0.968586 0.452607 KRT20 - Keratin, type I cytoskeletal 20 - Bos taurus (Bovine) - KRT20 gene Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). Taurus_UMD|evm.model.AC_000176.1.741 A6QQQ9 K1C20_BOVIN 88.971 0.918367 0.348341 KRT20 - Keratin, type I cytoskeletal 20 - Bos taurus (Bovine) - KRT20 gene Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). Taurus_UMD|evm.model.AC_000176.1.742 Q9C075 K1C23_HUMAN 75.472 0.995238 0.995261 KRT23 - Keratin, type I cytoskeletal 23 - Homo sapiens (Human) - KRT23 gene cytosol, cornification, keratinization Taurus_UMD|evm.model.AC_000176.1.743 Q6A163 K1C39_HUMAN 75.934 0.993802 0.985743 KRT39 - Keratin, type I cytoskeletal 39 - Homo sapiens (Human) - KRT39 gene May play a role in late hair differentiation. Taurus_UMD|evm.model.AC_000176.1.744 A7YWM2 K1C40_BOVIN 98.722 0.990476 0.730858 KRT40 - Keratin, type I cytoskeletal 40 - Bos taurus (Bovine) - KRT40 gene May play a role in late hair differentiation. Taurus_UMD|evm.model.AC_000176.1.745 Q24JX8 KRA31_BOVIN 98.980 0.979798 1.0102 KRTAP3-1 - Keratin-associated protein 3-1 - Bos taurus (Bovine) - KRTAP3-1 gene In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity). Taurus_UMD|evm.model.AC_000176.1.746 P02440 KRB2C_SHEEP 81.410 0.986395 0.967105 Keratin, high-sulfur matrix protein, B2C - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000176.1.747 P02440 KRB2C_SHEEP 87.179 0.987261 1.03289 Keratin, high-sulfur matrix protein, B2C - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000176.1.748 P02439 KRB2B_SHEEP 92.500 0.952096 1.07051 Keratin, high-sulfur matrix protein, B2B - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000176.1.749 P02442 KRA3_CAPHI 90.400 0.968504 0.962121 Keratin, high-sulfur matrix protein, IIIA3 - Capra hircus (Goat) Taurus_UMD|evm.model.AC_000176.1.750 P02442 KRA3_CAPHI 90.909 0.977444 1.00758 Keratin, high-sulfur matrix protein, IIIA3 - Capra hircus (Goat) Taurus_UMD|evm.model.AC_000176.1.751 P02442 KRA3_CAPHI 90.909 0.977444 1.00758 Keratin, high-sulfur matrix protein, IIIA3 - Capra hircus (Goat) Taurus_UMD|evm.model.AC_000176.1.752 P24049 RL17_RAT 97.283 0.989189 1.00543 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000176.1.753 P02442 KRA3_CAPHI 91.667 0.977444 1.00758 Keratin, high-sulfur matrix protein, IIIA3 - Capra hircus (Goat) Taurus_UMD|evm.model.AC_000176.1.763 A8MUX0 KR161_HUMAN 64.717 0.621483 1.51257 KRTAP16-1 - Keratin-associated protein 16-1 - Homo sapiens (Human) - KRTAP16-1 gene cytosol, keratinization Taurus_UMD|evm.model.AC_000176.1.764 P25690 K1M2_SHEEP 94.802 0.995025 0.99505 Keratin, type I microfibrillar, 47.6 kDa - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000176.1.765 P02534 K1M1_SHEEP 91.176 0.519531 1.86408 Keratin, type I microfibrillar 48 kDa, component 8C-1 - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000176.1.766 P02534 K1M1_SHEEP 97.349 0.992806 1.01214 Keratin, type I microfibrillar 48 kDa, component 8C-1 - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000176.1.767 O76015 KRT38_HUMAN 77.749 0.858108 0.973684 KRT38 - Keratin, type I cuticular Ha8 - Homo sapiens (Human) - KRT38 gene cytosol, extracellular exosome, structural molecule activity, cornification, keratinization Taurus_UMD|evm.model.AC_000176.1.768 O76015 KRT38_HUMAN 78.177 0.983333 0.789474 KRT38 - Keratin, type I cuticular Ha8 - Homo sapiens (Human) - KRT38 gene cytosol, extracellular exosome, structural molecule activity, cornification, keratinization Taurus_UMD|evm.model.AC_000176.1.769 B0LKP1 KRT35_SHEEP 90.549 0.569427 1.72527 KRT35 - Keratin, type I cuticular Ha5 - Ovis aries (Sheep) - KRT35 gene Taurus_UMD|evm.model.AC_000176.1.770 O76013 KRT36_HUMAN 84.449 0.991247 0.978587 KRT36 - Keratin, type I cuticular Ha6 - Homo sapiens (Human) - KRT36 gene cytosol, extracellular exosome, structural constituent of skin epidermis, cornification, keratinization Taurus_UMD|evm.model.AC_000176.1.771 P13646 K1C13_HUMAN 89.412 0.965517 0.949782 KRT13 - Keratin, type I cytoskeletal 13 - Homo sapiens (Human) - KRT13 gene cytosol, extracellular exosome, intermediate filament cytoskeleton, keratin filament, nucleus, cornification, cytoskeleton organization, keratinization Taurus_UMD|evm.model.AC_000176.1.772 O77727 K1C15_SHEEP 96.909 0.995595 1.00221 KRT15 - Keratin, type I cytoskeletal 15 - Ovis aries (Sheep) - KRT15 gene Taurus_UMD|evm.model.AC_000176.1.773 P08728 K1C19_BOVIN 100.000 0.995 1.00251 KRT19 - Keratin, type I cytoskeletal 19 - Bos taurus (Bovine) - KRT19 gene Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity). Taurus_UMD|evm.model.AC_000176.1.774 O18740 K1C9_CANLF 74.772 0.620038 0.673028 KRT9 - Keratin, type I cytoskeletal 9 - Canis lupus familiaris (Dog) - KRT9 gene May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly (By similarity). Taurus_UMD|evm.model.AC_000176.1.775 P02533 K1C14_HUMAN 95.845 0.751046 1.01271 KRT14 - Keratin, type I cytoskeletal 14 - Homo sapiens (Human) - KRT14 gene The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. Taurus_UMD|evm.model.AC_000176.1.776 P08779 K1C16_HUMAN 77.538 0.695946 0.938689 KRT16 - Keratin, type I cytoskeletal 16 - Homo sapiens (Human) - KRT16 gene Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. Taurus_UMD|evm.model.AC_000176.1.777 A1L595 K1C17_BOVIN 99.773 0.995475 1.00227 KRT17 - Keratin, type I cytoskeletal 17 - Bos taurus (Bovine) - KRT17 gene Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Taurus_UMD|evm.model.AC_000176.1.778 Q6IFX2 K1C42_MOUSE 91.574 0.991189 1.00442 Krt42 - Keratin, type I cytoskeletal 42 - Mus musculus (Mouse) - Krt42 gene Taurus_UMD|evm.model.AC_000176.1.779 Q5RFF4 EIF1_PONAB 100.000 0.982456 1.00885 EIF1 - Eukaryotic translation initiation factor 1 - Pongo abelii (Sumatran orangutan) - EIF1 gene Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA (By similarity). Taurus_UMD|evm.model.AC_000176.1.780 P01352 GAST_BOVIN 100.000 0.980952 1.00962 GAST - Gastrin precursor - Bos taurus (Bovine) - GAST gene Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. Taurus_UMD|evm.model.AC_000176.1.781 P54257 HAP1_HUMAN 60.061 0.987784 0.853949 HAP1 - Huntingtin-associated protein 1 - Homo sapiens (Human) - HAP1 gene Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17). Taurus_UMD|evm.model.AC_000176.1.782 Q8SPJ1 PLAK_BOVIN 100.000 0.939394 1.06309 JUP - Junction plakoglobin - Bos taurus (Bovine) - JUP gene Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). Taurus_UMD|evm.model.AC_000176.1.783 Q2HJ89 FKB10_BOVIN 100.000 0.208226 0.667238 FKBP10 - Peptidyl-prolyl cis-trans isomerase FKBP10 precursor - Bos taurus (Bovine) - FKBP10 gene PPIases accelerate the folding of proteins during protein synthesis. Taurus_UMD|evm.model.AC_000176.1.784 Q2HJ89 FKB10_BOVIN 99.800 0.968992 0.885077 FKBP10 - Peptidyl-prolyl cis-trans isomerase FKBP10 precursor - Bos taurus (Bovine) - FKBP10 gene PPIases accelerate the folding of proteins during protein synthesis. Taurus_UMD|evm.model.AC_000176.1.785 Q969T7 5NT3B_HUMAN 90.301 0.990033 1.00333 NT5C3B - 7-methylguanosine phosphate-specific 5'-nucleotidase - Homo sapiens (Human) - NT5C3B gene Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233). Taurus_UMD|evm.model.AC_000176.1.786 Q6JEL3 KLH10_RAT 99.671 0.996716 1.00164 Klhl10 - Kelch-like protein 10 - Rattus norvegicus (Rat) - Klhl10 gene May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. Taurus_UMD|evm.model.AC_000176.1.787 Q9NVR0 KLH11_HUMAN 99.153 0.997179 1.00141 KLHL11 - Kelch-like protein 11 precursor - Homo sapiens (Human) - KLHL11 gene Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. Taurus_UMD|evm.model.AC_000176.1.788 Q2TCH3 ACLY_SHEEP 99.364 0.998185 1.00091 ACLY - ATP-citrate synthase - Ovis aries (Sheep) - ACLY gene Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. Taurus_UMD|evm.model.AC_000176.1.789 Q96NG3 ODAD4_HUMAN 78.838 0.975146 1.01786 ODAD4 - Outer dynein arm-docking complex subunit 4 - Homo sapiens (Human) - ODAD4 gene Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Plays an essential role for the assembly of ODA-DC and for the docking of ODA in ciliary axoneme. Taurus_UMD|evm.model.AC_000176.1.790 P06623 CN37_BOVIN 100.000 0.947743 1.0525 CNP - 2',3'-cyclic-nucleotide 3'-phosphodiesterase precursor - Bos taurus (Bovine) - CNP gene May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Taurus_UMD|evm.model.AC_000176.1.791 Q99615 DNJC7_HUMAN 82.186 0.995604 0.921053 DNAJC7 - DnaJ homolog subfamily C member 7 - Homo sapiens (Human) - DNAJC7 gene Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). Taurus_UMD|evm.model.AC_000176.1.792 Q9NYR9 KBRS2_HUMAN 100.000 0.989583 1.00524 NKIRAS2 - NF-kappa-B inhibitor-interacting Ras-like protein 2 - Homo sapiens (Human) - NKIRAS2 gene Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). Taurus_UMD|evm.model.AC_000176.1.793 Q66K41 Z385C_HUMAN 83.095 0.946759 1.0237 ZNF385C - Zinc finger protein 385C - Homo sapiens (Human) - ZNF385C gene nucleus Taurus_UMD|evm.model.AC_000176.1.794 A0A1B0GUU1 CQ113_HUMAN 89.778 0.997041 1.00148 C17orf113 - Transmembrane protein C17orf113 - Homo sapiens (Human) - C17orf113 gene Taurus_UMD|evm.model.AC_000176.1.795 Q6PBT9 Z385B_DANRE 59.524 0.369369 0.22561 znf385b - Zinc finger protein 385B - Danio rerio (Zebrafish) - znf385b gene May play a role in p53/TP53-mediated apoptosis. Taurus_UMD|evm.model.AC_000176.1.796 Q96C10 DHX58_HUMAN 83.260 0.997063 1.00442 DHX58 - Probable ATP-dependent RNA helicase DHX58 - Homo sapiens (Human) - DHX58 gene Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses and coronavirus SARS-CoV-2, and also to the bacterial pathogen Listeria monocytogenes (PubMed:31256877). Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate. Taurus_UMD|evm.model.AC_000176.1.797 Q9JHD2 KAT2A_MOUSE 99.737 0.437644 1.04337 Kat2a - Histone acetyltransferase KAT2A - Mus musculus (Mouse) - Kat2a gene Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PubMed:28424240). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (By similarity). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (By similarity). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (By similarity). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:28424240). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (By similarity). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (PubMed:25024434). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (PubMed:28424240). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (PubMed:30424580). Regulates embryonic stem cell (ESC) pluripotency and differentiation (PubMed:30270482). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (By similarity). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (By similarity). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (By similarity). Taurus_UMD|evm.model.AC_000176.1.798 Q2TBQ6 HSPB9_BOVIN 100.000 0.987342 1.00637 HSPB9 - Heat shock protein beta-9 - Bos taurus (Bovine) - HSPB9 gene cytoplasm, nucleus Taurus_UMD|evm.model.AC_000176.1.799 Q58DS9 RAB5C_BOVIN 100.000 0.990783 1.00463 RAB5C - Ras-related protein Rab-5C - Bos taurus (Bovine) - RAB5C gene Protein transport. Probably involved in vesicular traffic. Taurus_UMD|evm.model.AC_000176.1.800 Q9UQ05 KCNH4_HUMAN 94.535 0.971559 0.864307 KCNH4 - Potassium voltage-gated channel subfamily H member 4 - Homo sapiens (Human) - KCNH4 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly. Taurus_UMD|evm.model.AC_000176.1.801 P56717 OREX_BOVIN 100.000 0.242424 4 HCRT - Orexin-A - Bos taurus (Bovine) - HCRT gene Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity). Taurus_UMD|evm.model.AC_000176.1.802 Q8N2G8 GHDC_HUMAN 83.465 0.956604 1 GHDC - GH3 domain-containing protein precursor - Homo sapiens (Human) - GHDC gene cytoplasm, extracellular region, membrane, secretory granule lumen, specific granule lumen, acid-amino acid ligase activity, neutrophil degranulation Taurus_UMD|evm.model.AC_000176.1.803 Q9TUM3 STA5B_BOVIN 99.746 0.997462 1.00127 STAT5B - Signal transducer and activator of transcription 5B - Bos taurus (Bovine) - STAT5B gene Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. Taurus_UMD|evm.model.AC_000176.1.804 Q95115 STA5A_BOVIN 97.619 0.997472 0.996222 STAT5A - Signal transducer and activator of transcription 5A - Bos taurus (Bovine) - STAT5A gene Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity). Taurus_UMD|evm.model.AC_000176.1.805 P40763 STAT3_HUMAN 99.740 0.997406 1.0013 STAT3 - Signal transducer and activator of transcription 3 - Homo sapiens (Human) - STAT3 gene Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). Taurus_UMD|evm.model.AC_000176.1.806 Q6NZI2 CAVN1_HUMAN 93.077 0.994885 1.00256 CAVIN1 - Caveolae-associated protein 1 - Homo sapiens (Human) - CAVIN1 gene Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). Taurus_UMD|evm.model.AC_000176.1.807 Q5E9I1 CCNG1_BOVIN 97.026 0.943662 0.962712 CCNG1 - Cyclin-G1 - Bos taurus (Bovine) - CCNG1 gene May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). Taurus_UMD|evm.model.AC_000176.1.808 Q29466 VPP1_BOVIN 99.165 0.997599 0.994033 ATP6V0A1 - V-type proton ATPase 116 kDa subunit a1 - Bos taurus (Bovine) - ATP6V0A1 gene Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). Taurus_UMD|evm.model.AC_000176.1.809 P54802 ANAG_HUMAN 86.591 0.943396 0.998654 NAGLU - Alpha-N-acetylglucosaminidase precursor - Homo sapiens (Human) - NAGLU gene Involved in the degradation of heparan sulfate. Taurus_UMD|evm.model.AC_000176.1.810 P14061 DHB1_HUMAN 73.540 0.91195 0.969512 HSD17B1 - 17-beta-hydroxysteroid dehydrogenase type 1 - Homo sapiens (Human) - HSD17B1 gene Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190). Also has 20-alpha-HSD activity. Uses preferentially NADH. Taurus_UMD|evm.model.AC_000176.1.812 Q8MIR4 COASY_PIG 93.772 0.996448 1.00178 COASY - Bifunctional coenzyme A synthase - Sus scrofa (Pig) - COASY gene Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. Taurus_UMD|evm.model.AC_000176.1.813 Q9UH92 MLX_HUMAN 94.966 0.993311 1.00336 MLX - Max-like protein X - Homo sapiens (Human) - MLX gene Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. Taurus_UMD|evm.model.AC_000176.1.814 Q9P2W1 HOP2_HUMAN 91.244 0.990826 1.00461 PSMC3IP - Homologous-pairing protein 2 homolog - Homo sapiens (Human) - PSMC3IP gene Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. Taurus_UMD|evm.model.AC_000176.1.815 Q86VR2 RETR3_HUMAN 93.562 0.995717 1.00215 RETREG3 - Reticulophagy regulator 3 - Homo sapiens (Human) - RETREG3 gene Mediates NRF1-enhanced neurite outgrowth. Taurus_UMD|evm.model.AC_000176.1.816 Q0VCD2 TBG1_BOVIN 100.000 0.995575 1.00222 TUBG1 - Tubulin gamma-1 chain - Bos taurus (Bovine) - TUBG1 gene Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity). Taurus_UMD|evm.model.AC_000176.1.817 Q32KM1 TBG2_BOVIN 100.000 0.995575 1.00222 TUBG2 - Tubulin gamma-2 chain - Bos taurus (Bovine) - TUBG2 gene Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity). Taurus_UMD|evm.model.AC_000176.1.818 Q7Z736 PKHH3_HUMAN 95.082 0.997478 1 PLEKHH3 - Pleckstrin homology domain-containing family H member 3 precursor - Homo sapiens (Human) - PLEKHH3 gene extracellular space Taurus_UMD|evm.model.AC_000176.1.819 P46092 CCR10_HUMAN 91.530 0.994536 1.01105 CCR10 - C-C chemokine receptor type 10 - Homo sapiens (Human) - CCR10 gene Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line. Taurus_UMD|evm.model.AC_000176.1.820 P78357 CNTP1_HUMAN 95.821 0.99856 1.00361 CNTNAP1 - Contactin-associated protein 1 precursor - Homo sapiens (Human) - CNTNAP1 gene Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells. Taurus_UMD|evm.model.AC_000176.1.821 A7E2Z2 EZH1_BOVIN 100.000 0.967575 1.03213 EZH1 - Histone-lysine N-methyltransferase EZH1 - Bos taurus (Bovine) - EZH1 gene Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. Taurus_UMD|evm.model.AC_000176.1.822 O60895 RAMP2_HUMAN 77.841 0.983146 1.01714 RAMP2 - Receptor activity-modifying protein 2 precursor - Homo sapiens (Human) - RAMP2 gene Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. Taurus_UMD|evm.model.AC_000176.1.823 Q5E9A6 VPS25_BOVIN 100.000 0.708502 1.40341 VPS25 - Vacuolar protein-sorting-associated protein 25 - Bos taurus (Bovine) - VPS25 gene Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL (By similarity). Taurus_UMD|evm.model.AC_000176.1.824 Q96J92 WNK4_HUMAN 87.862 0.998381 0.993564 WNK4 - Serine/threonine-protein kinase WNK4 - Homo sapiens (Human) - WNK4 gene Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity). Taurus_UMD|evm.model.AC_000176.1.825 Q3T0E3 COA3_BOVIN 100.000 0.981308 1.00943 COA3 - Cytochrome c oxidase assembly factor 3 homolog, mitochondrial - Bos taurus (Bovine) - COA3 gene Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly. Taurus_UMD|evm.model.AC_000176.1.826 Q9D995 CNTD1_MOUSE 89.172 0.923077 1.01198 Cntd1 - Cyclin N-terminal domain-containing protein 1 - Mus musculus (Mouse) - Cntd1 gene site of double-strand break, reciprocal meiotic recombination, spermatogenesis Taurus_UMD|evm.model.AC_000176.1.827 Q4A1L4 BECN1_BOVIN 100.000 0.833955 1.19643 BECN1 - Beclin-1 - Bos taurus (Bovine) - BECN1 gene Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense (By similarity). Taurus_UMD|evm.model.AC_000176.1.828 P61291 PSME3_PIG 100.000 0.992157 1.00394 PSME3 - Proteasome activator complex subunit 3 - Sus scrofa (Pig) - PSME3 gene Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (By similarity). Taurus_UMD|evm.model.AC_000176.1.830 O75106 AOC2_HUMAN 88.594 0.908323 1.09656 AOC2 - Retina-specific copper amine oxidase precursor - Homo sapiens (Human) - AOC2 gene Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina. Taurus_UMD|evm.model.AC_000176.1.831 Q9TTK6 AOC3_BOVIN 99.869 0.997382 1.00131 AOC3 - Membrane primary amine oxidase - Bos taurus (Bovine) - AOC3 gene Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity (By similarity). Taurus_UMD|evm.model.AC_000176.1.832 Q16853 AOC3_HUMAN 88.971 0.203313 0.870249 AOC3 - Membrane primary amine oxidase - Homo sapiens (Human) - AOC3 gene Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. Taurus_UMD|evm.model.AC_000176.1.833 O46406 AOCY_BOVIN 86.972 0.937086 0.396325 Primary amine oxidase, lung isozyme precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000176.1.834 Q29437 AOCX_BOVIN 99.861 0.921995 1.02625 Primary amine oxidase, liver isozyme precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000176.1.835 O46406 AOCY_BOVIN 89.460 0.961929 1.03412 Primary amine oxidase, lung isozyme precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000176.1.836 Q29RU6 G6PC1_BOVIN 100.000 0.994413 1.0028 G6PC1 - Glucose-6-phosphatase catalytic subunit 1 - Bos taurus (Bovine) - G6PC1 gene Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. Taurus_UMD|evm.model.AC_000176.1.837 Q32LK1 AASD1_BOVIN 92.568 0.995157 0.93018 AARSD1 - Alanyl-tRNA editing protein Aarsd1 - Bos taurus (Bovine) - AARSD1 gene Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). Taurus_UMD|evm.model.AC_000176.1.838 Q9D9A7 PTG3L_MOUSE 92.063 0.801282 1.19084 Ptges3l - Putative protein PTGES3L - Mus musculus (Mouse) - Ptges3l gene cytosol, nucleus, chaperone binding, Hsp90 protein binding, chaperone-mediated protein complex assembly, protein folding Taurus_UMD|evm.model.AC_000176.1.839 Q96C34 RUND1_HUMAN 93.023 0.978827 1.00163 RUNDC1 - RUN domain-containing protein 1 - Homo sapiens (Human) - RUNDC1 gene May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. Taurus_UMD|evm.model.AC_000176.1.840 P61354 RL27_RAT 100.000 0.985401 1.00735 Rpl27 - 60S ribosomal protein L27 - Rattus norvegicus (Rat) - Rpl27 gene Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity). Taurus_UMD|evm.model.AC_000176.1.841 P80217 IN35_HUMAN 73.333 0.933555 1.05245 IFI35 - Interferon-induced 35 kDa protein - Homo sapiens (Human) - IFI35 gene Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (PubMed:10779520, PubMed:10950963). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (PubMed:26342464). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (PubMed:29038465). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of proinflammatory cytokines (PubMed:29038465). Taurus_UMD|evm.model.AC_000176.1.842 Q62465 VAT1_MOUSE 90.691 0.930521 0.992611 Vat1 - Synaptic vesicle membrane protein VAT-1 homolog - Mus musculus (Mouse) - Vat1 gene Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation (By similarity). Possesses ATPase activity. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (By similarity). Taurus_UMD|evm.model.AC_000176.1.843 P52198 RND2_HUMAN 96.137 0.991453 1.03084 RND2 - Rho-related GTP-binding protein RhoN precursor - Homo sapiens (Human) - RND2 gene May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity). Taurus_UMD|evm.model.AC_000176.1.844 Q864U1 BRCA1_BOVIN 99.892 0.998919 1.00054 BRCA1 - Breast cancer type 1 susceptibility protein homolog - Bos taurus (Bovine) - BRCA1 gene E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator. Taurus_UMD|evm.model.AC_000176.1.845 Q5RC94 NBR1_PONAB 87.889 0.291793 1.10403 NBR1 - Next to BRCA1 gene 1 protein - Pongo abelii (Sumatran orangutan) - NBR1 gene Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. Taurus_UMD|evm.model.AC_000176.1.846 Q5EA90 T106A_BOVIN 100.000 0.992366 1.00383 TMEM106A - Transmembrane protein 106A - Bos taurus (Bovine) - TMEM106A gene Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (By similarity). Taurus_UMD|evm.model.AC_000176.1.847 P62305 RUXE_MOUSE 95.652 0.978495 1.01087 Snrpe - Small nuclear ribonucleoprotein E - Mus musculus (Mouse) - Snrpe gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. Taurus_UMD|evm.model.AC_000176.1.848 Q0VC18 ARL4D_BOVIN 100.000 0.99005 1.005 ARL4D - ADP-ribosylation factor-like protein 4D - Bos taurus (Bovine) - ARL4D gene Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity). Taurus_UMD|evm.model.AC_000176.1.849 Q14562 DHX8_HUMAN 98.443 0.998359 0.99918 DHX8 - ATP-dependent RNA helicase DHX8 - Homo sapiens (Human) - DHX8 gene Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). Taurus_UMD|evm.model.AC_000176.1.850 P43268 ETV4_HUMAN 95.258 0.914934 1.09298 ETV4 - ETS translocation variant 4 - Homo sapiens (Human) - ETV4 gene Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090). Taurus_UMD|evm.model.AC_000176.1.851 A2T7T2 MEOX1_PONPY 89.764 0.992157 1.00394 MEOX1 - Homeobox protein MOX-1 - Pongo pygmaeus (Bornean orangutan) - MEOX1 gene Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Taurus_UMD|evm.model.AC_000176.1.852 Q9BG79 SOST_BOVIN 99.528 0.99061 1.00472 SOST - Sclerostin precursor - Bos taurus (Bovine) - SOST gene Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. Taurus_UMD|evm.model.AC_000176.1.853 Q5RD73 DUS3_PONAB 98.370 0.983871 1.00541 DUSP3 - Dual specificity protein phosphatase 3 - Pongo abelii (Sumatran orangutan) - DUSP3 gene Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 (By similarity). Taurus_UMD|evm.model.AC_000176.1.854 B2RV13 CF97D_HUMAN 90.244 0.987879 1.0061 CFAP97D1 - Sperm axonemal maintenance protein CFAP97D1 - Homo sapiens (Human) - CFAP97D1 gene Required for male fertility through its role in axonemal doublet stabilization which is essential for sperm motility and fertilization. Taurus_UMD|evm.model.AC_000176.1.855 Q13368 MPP3_HUMAN 93.333 0.996587 1.00171 MPP3 - MAGUK p55 subfamily member 3 - Homo sapiens (Human) - MPP3 gene Taurus_UMD|evm.model.AC_000176.1.856 A5D7B2 CLM9_BOVIN 95.294 0.991803 0.956863 CD300LG - CMRF35-like molecule 9 precursor - Bos taurus (Bovine) - CD300LG gene Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity). Taurus_UMD|evm.model.AC_000176.1.857 D3ZAA9 MPP2_RAT 98.188 0.909241 1.09783 Mpp2 - MAGUK p55 subfamily member 2 - Rattus norvegicus (Rat) - Mpp2 gene Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (PubMed:27756895). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (By similarity). Taurus_UMD|evm.model.AC_000176.1.858 P01302 PAHO_BOVIN 100.000 0.491525 1.35115 PPY - Pancreatic prohormone precursor - Bos taurus (Bovine) - PPY gene Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. Taurus_UMD|evm.model.AC_000176.1.859 P06833 PYY2_BOVIN 90.476 0.632653 1.225 PYY2 - Caltrin precursor - Bos taurus (Bovine) - PYY2 gene Inhibits calcium transport into spermatozoa; it does not bind directly to calcium. Binds to calmodulin. Inhibits the growth of microorganisms. Seem to act as an antibiotic by permeabilizing the bacterial membrane. Taurus_UMD|evm.model.AC_000176.1.860 Q8N159 NAGS_HUMAN 88.690 0.940187 1.00187 NAGS - N-acetylglutamate synthase, mitochondrial precursor - Homo sapiens (Human) - NAGS gene Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity. Taurus_UMD|evm.model.AC_000176.1.861 Q2KIB3 TM101_BOVIN 100.000 0.992248 1.00389 TMEM101 - Transmembrane protein 101 - Bos taurus (Bovine) - TMEM101 gene May activate NF-kappa-B signaling pathways. Taurus_UMD|evm.model.AC_000176.1.862 Q5RAT5 LSM12_PONAB 100.000 0.989796 1.00513 LSM12 - Protein LSM12 homolog - Pongo abelii (Sumatran orangutan) - LSM12 gene Taurus_UMD|evm.model.AC_000176.1.863 Q148G2 G6PC3_BOVIN 100.000 0.994236 1.00289 G6PC3 - Glucose-6-phosphatase 3 - Bos taurus (Bovine) - G6PC3 gene Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function (By similarity). Taurus_UMD|evm.model.AC_000176.1.864 Q80ZH1 HDAC5_CRIGR 95.434 0.998211 1.0063 HDAC5 - Histone deacetylase 5 - Cricetulus griseus (Chinese hamster) - HDAC5 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). Serves as a corepressor of RARA and causes its deacetylation (By similarity). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity). Taurus_UMD|evm.model.AC_000176.1.866 Q8N3J3 HROB_HUMAN 72.256 0.981679 1.01236 HROB - Homologous recombination OB-fold protein - Homo sapiens (Human) - HROB gene DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. Taurus_UMD|evm.model.AC_000176.1.867 Q96NS5 ASB16_HUMAN 88.521 0.995595 1.00221 ASB16 - Ankyrin repeat and SOCS box protein 16 - Homo sapiens (Human) - ASB16 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000176.1.868 Q2HJA8 TMUB2_BOVIN 99.689 0.993808 1.00311 TMUB2 - Transmembrane and ubiquitin-like domain-containing protein 2 - Bos taurus (Bovine) - TMUB2 gene ubiquitin-dependent ERAD pathway Taurus_UMD|evm.model.AC_000176.1.870 Q14CW9 AT7L3_HUMAN 94.262 0.9125 1.15274 ATXN7L3 - Ataxin-7-like protein 3 - Homo sapiens (Human) - ATXN7L3 gene Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583). Taurus_UMD|evm.model.AC_000176.1.871 P17480 UBF1_HUMAN 96.597 0.765182 1.29319 UBTF - Nucleolar transcription factor 1 - Homo sapiens (Human) - UBTF gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. Taurus_UMD|evm.model.AC_000176.1.872 P02730 B3AT_HUMAN 76.699 0.993555 1.02195 SLC4A1 - Band 3 anion transport protein - Homo sapiens (Human) - SLC4A1 gene Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. Taurus_UMD|evm.model.AC_000176.1.873 Q17QK1 RUN3A_BOVIN 98.879 0.995526 1.01361 RUNDC3A - RUN domain-containing protein 3A - Bos taurus (Bovine) - RUNDC3A gene May act as an effector of RAP2A in neuronal cells. Taurus_UMD|evm.model.AC_000176.1.874 Q17QI7 S2539_BOVIN 100.000 0.994444 1.00279 SLC25A39 - Solute carrier family 25 member 39 - Bos taurus (Bovine) - SLC25A39 gene Required for normal heme biosynthesis. Taurus_UMD|evm.model.AC_000176.1.875 P28799 GRN_HUMAN 76.560 0.996599 0.991568 GRN - Progranulin precursor - Homo sapiens (Human) - GRN gene Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:28541286, PubMed:28073925, PubMed:18378771, PubMed:28453791, PubMed:12526812). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:18378771). Taurus_UMD|evm.model.AC_000176.1.876 A8MVW0 F1712_HUMAN 92.203 0.993243 0.358354 FAM171A2 - Protein FAM171A2 precursor - Homo sapiens (Human) - FAM171A2 gene Taurus_UMD|evm.model.AC_000176.1.877 A8MVW0 F1712_HUMAN 94.632 0.922794 0.658596 FAM171A2 - Protein FAM171A2 precursor - Homo sapiens (Human) - FAM171A2 gene Taurus_UMD|evm.model.AC_000176.1.878 P53711 ITA2B_PAPCY 81.561 0.576812 1.71358 ITGA2B - Integrin alpha-IIb - Papio cynocephalus (Yellow baboon) - ITGA2B gene Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Taurus_UMD|evm.model.AC_000176.1.879 Q9UKJ3 GPTC8_HUMAN 92.185 0.998675 1.00533 GPATCH8 - G patch domain-containing protein 8 - Homo sapiens (Human) - GPATCH8 gene nucleus, RNA binding Taurus_UMD|evm.model.AC_000176.1.880 Q14332 FZD2_HUMAN 99.823 0.996466 1.00177 FZD2 - Frizzled-2 precursor - Homo sapiens (Human) - FZD2 gene Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:25759469). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Taurus_UMD|evm.model.AC_000176.1.881 A2AG06 MEIOC_MOUSE 90.784 0.996812 0.97513 Meioc - Meiosis-specific coiled-coil domain-containing protein MEIOC - Mus musculus (Mouse) - Meioc gene Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle (PubMed:28380054). Taurus_UMD|evm.model.AC_000176.1.882 Q96MW1 CCD43_HUMAN 92.070 0.991228 1.01786 CCDC43 - Coiled-coil domain-containing protein 43 - Homo sapiens (Human) - CCDC43 gene cytosol Taurus_UMD|evm.model.AC_000176.1.883 O75078 ADA11_HUMAN 94.947 0.57372 1.70221 ADAM11 - Disintegrin and metalloproteinase domain-containing protein 11 precursor - Homo sapiens (Human) - ADAM11 gene Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Taurus_UMD|evm.model.AC_000176.1.884 Q2HJ66 CXG1_BOVIN 100.000 0.994962 1.00253 GJC1 - Gap junction gamma-1 protein - Bos taurus (Bovine) - GJC1 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Taurus_UMD|evm.model.AC_000176.1.885 Q9P298 HIG1B_HUMAN 85.859 0.98 1.0101 HIGD1B - HIG1 domain family member 1B - Homo sapiens (Human) - HIGD1B gene mitochondrion, mitochondrial respirasome assembly Taurus_UMD|evm.model.AC_000176.1.886 A4FUD3 U5S1_BOVIN 99.897 0.997945 1.00103 EFTUD2 - 116 kDa U5 small nuclear ribonucleoprotein component - Bos taurus (Bovine) - EFTUD2 gene Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity). Taurus_UMD|evm.model.AC_000176.1.887 Q8IW40 CC103_HUMAN 80.717 0.662687 1.3843 CCDC103 - Coiled-coil domain-containing protein 103 - Homo sapiens (Human) - CCDC103 gene Dynein-attachment factor required for cilia motility. Taurus_UMD|evm.model.AC_000176.1.888 A7E3C4 F187A_BOVIN 100.000 0.995261 1.00238 FAM187A - Ig-like V-type domain-containing protein FAM187A precursor - Bos taurus (Bovine) - FAM187A gene Taurus_UMD|evm.model.AC_000176.1.889 Q28115 GFAP_BOVIN 100.000 0.995338 1.00234 GFAP - Glial fibrillary acidic protein - Bos taurus (Bovine) - GFAP gene GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. Taurus_UMD|evm.model.AC_000176.1.890 Q86Y91 KI18B_HUMAN 77.471 0.99537 1.01408 KIF18B - Kinesin-like protein KIF18B - Homo sapiens (Human) - KIF18B gene In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules. Taurus_UMD|evm.model.AC_000176.1.891 O75973 C1QRF_HUMAN 98.374 0.865724 1.0969 C1QL1 - C1q-related factor precursor - Homo sapiens (Human) - C1QL1 gene May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Taurus_UMD|evm.model.AC_000176.1.892 Q3ZBS0 DCAKD_BOVIN 100.000 0.991379 1.00433 DCAKD - Dephospho-CoA kinase domain-containing protein - Bos taurus (Bovine) - DCAKD gene dephospho-CoA kinase activity, coenzyme A biosynthetic process Taurus_UMD|evm.model.AC_000176.1.893 P31717 NMT1_BOVIN 99.396 0.995976 1 NMT1 - Glycylpeptide N-tetradecanoyltransferase 1 - Bos taurus (Bovine) - NMT1 gene Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Taurus_UMD|evm.model.AC_000176.1.894 Q8N3E9 PLCD3_HUMAN 86.918 0.957524 1.04436 PLCD3 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 - Homo sapiens (Human) - PLCD3 gene Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity). Taurus_UMD|evm.model.AC_000176.1.895 Q2KHT9 ACBD4_BOVIN 100.000 0.934985 1.06601 ACBD4 - Acyl-CoA-binding domain-containing protein 4 - Bos taurus (Bovine) - ACBD4 gene Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters. Taurus_UMD|evm.model.AC_000176.1.896 Q0X0C4 HEXI1_BOVIN 100.000 0.993769 1.00313 HEXIM1 - Protein HEXIM1 - Bos taurus (Bovine) - HEXIM1 gene Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Taurus_UMD|evm.model.AC_000176.1.897 Q0X0E2 HEXI2_BOVIN 99.653 0.99308 1.00697 HEXIM2 - Protein HEXIM2 - Bos taurus (Bovine) - HEXIM2 gene Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. Taurus_UMD|evm.model.AC_000176.1.898 O95466 FMNL1_HUMAN 91.213 0.424 1.02273 FMNL1 - Formin-like protein 1 - Homo sapiens (Human) - FMNL1 gene May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Taurus_UMD|evm.model.AC_000176.1.899 Q96LK8 SPT32_HUMAN 37.632 0.515106 1.72396 SPATA32 - Spermatogenesis-associated protein 32 - Homo sapiens (Human) - SPATA32 gene perinuclear region of cytoplasm, actin binding, spermatogenesis Taurus_UMD|evm.model.AC_000176.1.901 Q99558 M3K14_HUMAN 88.180 0.997904 1.00739 MAP3K14 - Mitogen-activated protein kinase kinase kinase 14 - Homo sapiens (Human) - MAP3K14 gene Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner. Taurus_UMD|evm.model.AC_000176.1.902 Q6TLK4 RHG27_RAT 82.093 0.692737 0.823936 Arhgap27 - Rho GTPase-activating protein 27 - Rattus norvegicus (Rat) - Arhgap27 gene Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1. Taurus_UMD|evm.model.AC_000176.1.903 Q9Y4G2 PKHM1_HUMAN 81.490 0.473233 0.88447 PLEKHM1 - Pleckstrin homology domain-containing family M member 1 - Homo sapiens (Human) - PLEKHM1 gene Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes (PubMed:25498145, PubMed:28325809). Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity). Taurus_UMD|evm.model.AC_000176.1.904 Q49AS3 L37A5_HUMAN 80.822 0.0277669 24.1226 LRRC37A5P - Putative protein LRRC37A5P - Homo sapiens (Human) - LRRC37A5P gene Taurus_UMD|evm.model.AC_000176.1.905 Q4R856 RDM1_MACFA 80.351 0.993007 1.00704 RDM1 - RAD52 motif-containing protein 1 - Macaca fascicularis (Crab-eating macaque) - RDM1 gene May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA (By similarity). Taurus_UMD|evm.model.AC_000176.1.906 Q29RT1 LYZL6_BOVIN 99.324 0.986577 1.00676 LYZL6 - Lysozyme-like protein 6 precursor - Bos taurus (Bovine) - LYZL6 gene May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6 (By similarity). Taurus_UMD|evm.model.AC_000176.1.908 Q8N4K4 RPRML_HUMAN 90.083 0.983607 1.01667 RPRML - Reprimo-like protein - Homo sapiens (Human) - RPRML gene Taurus_UMD|evm.model.AC_000176.1.909 O35165 GOSR2_RAT 93.868 0.99061 1.00472 Gosr2 - Golgi SNAP receptor complex member 2 - Rattus norvegicus (Rat) - Gosr2 gene Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. Taurus_UMD|evm.model.AC_000176.1.910 O14905 WNT9B_HUMAN 92.737 0.994413 1.0028 WNT9B - Protein Wnt-9b precursor - Homo sapiens (Human) - WNT9B gene Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity). Taurus_UMD|evm.model.AC_000176.1.911 P56703 WNT3_HUMAN 99.155 0.994382 1.00282 WNT3 - Proto-oncogene Wnt-3 precursor - Homo sapiens (Human) - WNT3 gene Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406). Taurus_UMD|evm.model.AC_000176.1.912 P46459 NSF_HUMAN 99.059 0.98672 1.0121 NSF - Vesicle-fusing ATPase - Homo sapiens (Human) - NSF gene Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). Taurus_UMD|evm.model.AC_000176.1.913 P84082 ARF2_RAT 100.000 0.989011 1.00552 Arf2 - ADP-ribosylation factor 2 - Rattus norvegicus (Rat) - Arf2 gene GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Taurus_UMD|evm.model.AC_000176.1.915 Q76LL8 CRFR1_MACMU 89.880 0.994819 0.93012 CRHR1 - Corticotropin-releasing factor receptor 1 precursor - Macaca mulatta (Rhesus macaque) - CRHR1 gene G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. Taurus_UMD|evm.model.AC_000176.1.916 Q8IUH8 SPP2C_HUMAN 73.199 0.997106 1.01023 SPPL2C - Signal peptide peptidase-like 2C precursor - Homo sapiens (Human) - SPPL2C gene Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane. Taurus_UMD|evm.model.AC_000176.1.918 O02828 TAU_CAPHI 97.411 0.503289 1.50868 MAPT - Microtubule-associated protein tau - Capra hircus (Goat) - MAPT gene Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Taurus_UMD|evm.model.AC_000176.1.921 Q7Z3B3 KANL1_HUMAN 94.123 0.998188 0.999095 KANSL1 - KAT8 regulatory NSL complex subunit 1 - Homo sapiens (Human) - KANSL1 gene As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. Taurus_UMD|evm.model.AC_000176.1.922 A7Z061 CDC27_BOVIN 99.879 0.997576 1 CDC27 - Cell division cycle protein 27 homolog - Bos taurus (Bovine) - CDC27 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Taurus_UMD|evm.model.AC_000176.1.923 P12829 MYL4_HUMAN 91.411 0.566901 1.44162 MYL4 - Myosin light chain 4 - Homo sapiens (Human) - MYL4 gene Regulatory light chain of myosin. Does not bind calcium. Taurus_UMD|evm.model.AC_000176.1.924 Q7Z417 NUFP2_HUMAN 92.273 0.947445 0.985612 NUFIP2 - Nuclear fragile X mental retardation-interacting protein 2 - Homo sapiens (Human) - NUFIP2 gene Binds RNA. Taurus_UMD|evm.model.AC_000176.1.925 P05106 ITB3_HUMAN 95.402 0.996178 0.996193 ITGB3 - Integrin beta-3 precursor - Homo sapiens (Human) - ITGB3 gene Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887). In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973). Taurus_UMD|evm.model.AC_000176.1.926 Q2T9P0 EFCB3_BOVIN 99.543 0.115578 8.63242 EFCAB3 - EF-hand calcium-binding domain-containing protein 3 - Bos taurus (Bovine) - EFCAB3 gene Taurus_UMD|evm.model.AC_000176.1.927 Q0P5B2 METL2_BOVIN 100.000 0.994723 1.00265 METTL2 - tRNA N(3)-methylcytidine methyltransferase METTL2 - Bos taurus (Bovine) - METTL2 gene S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Taurus_UMD|evm.model.AC_000176.1.929 Q86UE8 TLK2_HUMAN 96.632 0.939774 1.03238 TLK2 - Serine/threonine-protein kinase tousled-like 2 - Homo sapiens (Human) - TLK2 gene Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. Taurus_UMD|evm.model.AC_000176.1.930 Q9UBG0 MRC2_HUMAN 92.552 0.989262 1.00744 MRC2 - C-type mannose receptor 2 precursor - Homo sapiens (Human) - MRC2 gene May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). Taurus_UMD|evm.model.AC_000176.1.931 Q8NA82 MARHA_HUMAN 71.711 0.155763 1.19183 MARCHF10 - Probable E3 ubiquitin-protein ligase MARCHF10 - Homo sapiens (Human) - MARCHF10 gene E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Taurus_UMD|evm.model.AC_000176.1.932 Q9HCD6 TANC2_HUMAN 100.000 0.0339147 1.03719 TANC2 - Protein TANC2 - Homo sapiens (Human) - TANC2 gene Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. Taurus_UMD|evm.model.AC_000176.1.933 P10897 CY561_BOVIN 100.000 0.992095 1.00397 CYB561 - Transmembrane ascorbate-dependent reductase CYB561 - Bos taurus (Bovine) - CYB561 gene Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles (PubMed:3597367, PubMed:1623014, PubMed:18501187). It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes (Probable). Taurus_UMD|evm.model.AC_000176.1.935 P12820 ACE_BOVIN 100.000 0.557823 1.47 ACE - Angiotensin-converting enzyme precursor - Bos taurus (Bovine) - ACE gene Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity). Taurus_UMD|evm.model.AC_000176.1.936 P12822 ACE_RABIT 83.170 0.986566 0.90916 ACE - Angiotensin-converting enzyme precursor - Oryctolagus cuniculus (Rabbit) - ACE gene Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity). Taurus_UMD|evm.model.AC_000176.1.937 D0G895 ACE3_MOUSE 68.904 0.938224 1.05427 Ace3 - Angiotensin-converting enzyme-like protein Ace3 precursor - Mus musculus (Mouse) - Ace3 gene acrosomal vesicle, plasma membrane, metallopeptidase activity, peptidyl-dipeptidase activity, positive regulation of systemic arterial blood pressure, regulation of systemic arterial blood pressure by renin-angiotensin Taurus_UMD|evm.model.AC_000176.1.938 O54853 KCNH6_RAT 89.770 0.997914 1.00947 Kcnh6 - Potassium voltage-gated channel subfamily H member 6 - Rattus norvegicus (Rat) - Kcnh6 gene Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Taurus_UMD|evm.model.AC_000176.1.939 P61963 DCAF7_MOUSE 100.000 0.994169 1.00292 Dcaf7 - DDB1- and CUL4-associated factor 7 - Mus musculus (Mouse) - Dcaf7 gene Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). Taurus_UMD|evm.model.AC_000176.1.940 Q9BSH4 TACO1_HUMAN 84.452 0.946309 1.00337 TACO1 - Translational activator of cytochrome c oxidase 1 - Homo sapiens (Human) - TACO1 gene Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Taurus_UMD|evm.model.AC_000176.1.941 Q99759 M3K3_HUMAN 92.542 0.99696 1.05112 MAP3K3 - Mitogen-activated protein kinase kinase kinase 3 - Homo sapiens (Human) - MAP3K3 gene Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. Taurus_UMD|evm.model.AC_000176.1.942 Q1LZA7 LIMD2_BOVIN 100.000 0.984496 1.00781 LIMD2 - LIM domain-containing protein 2 - Bos taurus (Bovine) - LIMD2 gene Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. Taurus_UMD|evm.model.AC_000176.1.943 Q5E9J9 STRAA_BOVIN 100.000 0.861111 1.15818 STRADA - STE20-related kinase adapter protein alpha - Bos taurus (Bovine) - STRADA gene Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). Taurus_UMD|evm.model.AC_000176.1.944 P0C204 CCD47_MACFA 97.414 0.684524 0.347826 CCDC47 - PAT complex subunit CCDC47 precursor - Macaca fascicularis (Crab-eating macaque) - CCDC47 gene Component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. WDR83OS/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS/Asterix. The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which the first transmembrane domain binds. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (By similarity). Has an essential role in the maintenance of ER organization during embryogenesis (By similarity). Taurus_UMD|evm.model.AC_000176.1.945 Q3ZC50 CCD47_BOVIN 99.369 0.990596 0.660455 CCDC47 - PAT complex subunit CCDC47 precursor - Bos taurus (Bovine) - CCDC47 gene Component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. WDR83OS/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS/Asterix. The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which the first transmembrane domain binds. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (By similarity). Has an essential role in the maintenance of ER organization during embryogenesis (By similarity). Taurus_UMD|evm.model.AC_000176.1.946 Q86XP3 DDX42_HUMAN 93.691 0.958932 1.03838 DDX42 - ATP-dependent RNA helicase DDX42 - Homo sapiens (Human) - DDX42 gene ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm. Taurus_UMD|evm.model.AC_000176.1.947 Q9DBE9 SPB1_MOUSE 85.560 0.982185 1.00477 Ftsj3 - pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 - Mus musculus (Mouse) - Ftsj3 gene RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Taurus_UMD|evm.model.AC_000176.1.948 P62198 PRS8_RAT 100.000 0.995086 1.00246 Psmc5 - 26S proteasome regulatory subunit 8 - Rattus norvegicus (Rat) - Psmc5 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Taurus_UMD|evm.model.AC_000176.1.949 E1BJD1 SMRD2_BOVIN 100.000 0.996241 1.00188 SMARCD2 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 - Bos taurus (Bovine) - SMARCD2 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation. Taurus_UMD|evm.model.AC_000176.1.950 Q60625 ICAM5_MOUSE 41.304 0.164234 0.597601 Icam5 - Intercellular adhesion molecule 5 precursor - Mus musculus (Mouse) - Icam5 gene ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). Taurus_UMD|evm.model.AC_000176.1.951 P01246 SOMA_BOVIN 100.000 0.990783 1 GH1 - Somatotropin precursor - Bos taurus (Bovine) - GH1 gene Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Taurus_UMD|evm.model.AC_000176.1.952 P40259 CD79B_HUMAN 69.264 0.991342 1.00873 CD79B - B-cell antigen receptor complex-associated protein beta chain precursor - Homo sapiens (Human) - CD79B gene Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Taurus_UMD|evm.model.AC_000176.1.953 P35499 SCN4A_HUMAN 90.620 0.998937 1.02451 SCN4A - Sodium channel protein type 4 subunit alpha - Homo sapiens (Human) - SCN4A gene Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states (PubMed:12766226, PubMed:29992740, PubMed:30190309, PubMed:15318338, PubMed:16890191, PubMed:18690054, PubMed:17898326, PubMed:19347921, PubMed:25707578, PubMed:26700687). Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K(+) levels (PubMed:12766226, PubMed:15318338, PubMed:16890191, PubMed:19347921, PubMed:25707578, PubMed:26700687, PubMed:26659129). Taurus_UMD|evm.model.AC_000176.1.954 Q5NKV1 ICAM2_GORGO 51.095 0.978182 1 ICAM2 - Intercellular adhesion molecule 2 precursor - Gorilla gorilla gorilla (Western lowland gorilla) - ICAM2 gene ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity). Taurus_UMD|evm.model.AC_000176.1.955 Q5NKV1 ICAM2_GORGO 52.653 0.956349 0.916364 ICAM2 - Intercellular adhesion molecule 2 precursor - Gorilla gorilla gorilla (Western lowland gorilla) - ICAM2 gene ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity). Taurus_UMD|evm.model.AC_000176.1.956 Q5NKV1 ICAM2_GORGO 49.580 0.405217 2.09091 ICAM2 - Intercellular adhesion molecule 2 precursor - Gorilla gorilla gorilla (Western lowland gorilla) - ICAM2 gene ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity). Taurus_UMD|evm.model.AC_000176.1.957 O75460 ERN1_HUMAN 94.363 0.976459 1 ERN1 - Serine/threonine-protein kinase/endoribonuclease IRE1 precursor - Homo sapiens (Human) - ERN1 gene Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875, PubMed:28128204). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262). Taurus_UMD|evm.model.AC_000176.1.958 Q8IWB9 TEX2_HUMAN 89.046 0.996226 0.94055 TEX2 - Testis-expressed protein 2 - Homo sapiens (Human) - TEX2 gene During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. Taurus_UMD|evm.model.AC_000176.1.959 Q8IWB9 TEX2_HUMAN 93.671 0.886364 0.0780834 TEX2 - Testis-expressed protein 2 - Homo sapiens (Human) - TEX2 gene During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. Taurus_UMD|evm.model.AC_000176.1.960 P51866 PECA1_BOVIN 98.784 0.997294 1 PECAM1 - Platelet endothelial cell adhesion molecule precursor - Bos taurus (Bovine) - PECAM1 gene Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-689 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis. Taurus_UMD|evm.model.AC_000176.1.961 Q7Z6M3 MILR1_HUMAN 63.063 0.973607 0.994169 MILR1 - Allergin-1 precursor - Homo sapiens (Human) - MILR1 gene Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity). Taurus_UMD|evm.model.AC_000176.1.962 Q0VC30 DPOG2_BOVIN 100.000 0.995885 1.00206 POLG2 - DNA polymerase subunit gamma-2, mitochondrial precursor - Bos taurus (Bovine) - POLG2 gene Mitochondrial polymerase processivity subunit. It regulates the polymerase and exonuclease activities promoting processive DNA synthesis. Binds to ss-DNA. Taurus_UMD|evm.model.AC_000176.1.963 P17844 DDX5_HUMAN 100.000 0.996748 1.00163 DDX5 - Probable ATP-dependent RNA helicase DDX5 - Homo sapiens (Human) - DDX5 gene Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Taurus_UMD|evm.model.AC_000176.1.964 Q96GE4 CEP95_HUMAN 82.614 0.894118 1.03532 CEP95 - Centrosomal protein of 95 kDa - Homo sapiens (Human) - CEP95 gene centrosome, spindle pole Taurus_UMD|evm.model.AC_000176.1.965 Q9HAU4 SMUF2_HUMAN 98.978 0.981322 0.930481 SMURF2 - E3 ubiquitin-protein ligase SMURF2 - Homo sapiens (Human) - SMURF2 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11016919). Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling (PubMed:11163210, PubMed:12717440). In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1 (PubMed:18448069). Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation (PubMed:11016919, PubMed:11158580, PubMed:11389444). SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation (PubMed:11389444). Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation (PubMed:30696809). Taurus_UMD|evm.model.AC_000176.1.966 P52292 IMA1_HUMAN 95.274 0.996226 1.00189 KPNA2 - Importin subunit alpha-1 - Homo sapiens (Human) - KPNA2 gene Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Taurus_UMD|evm.model.AC_000176.1.967 Q2M2W7 CQ058_HUMAN 91.111 0.589404 1.5567 C17orf58 - UPF0450 protein C17orf58 - Homo sapiens (Human) - C17orf58 gene collagen-containing extracellular matrix Taurus_UMD|evm.model.AC_000176.1.968 Q12830 BPTF_HUMAN 89.153 0.827784 0.91694 BPTF - Nucleosome-remodeling factor subunit BPTF - Homo sapiens (Human) - BPTF gene Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. Taurus_UMD|evm.model.AC_000176.1.969 Q3MHH2 NOL11_BOVIN 100.000 0.997218 1.00139 NOL11 - Nucleolar protein 11 - Bos taurus (Bovine) - NOL11 gene Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b (By similarity). Taurus_UMD|evm.model.AC_000176.1.970 Q9UKF7 PITC1_HUMAN 98.193 0.993994 1.00301 PITPNC1 - Cytoplasmic phosphatidylinositol transfer protein 1 - Homo sapiens (Human) - PITPNC1 gene Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (PubMed:10531358, PubMed:22822086). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species (PubMed:22822086). Taurus_UMD|evm.model.AC_000176.1.971 Q2KJ25 PSD12_BOVIN 100.000 0.995624 1.00219 PSMD12 - 26S proteasome non-ATPase regulatory subunit 12 - Bos taurus (Bovine) - PSMD12 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Taurus_UMD|evm.model.AC_000176.1.973 Q641Q3 METRL_HUMAN 83.146 0.858065 0.996785 METRNL - Meteorin-like protein precursor - Homo sapiens (Human) - METRNL gene Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity). Taurus_UMD|evm.model.AC_000176.1.974 Q6GV29 B3GNL_RAT 72.941 0.463687 0.501401 B3gntl1 - UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 - Rattus norvegicus (Rat) - B3gntl1 gene Putative glycosyltransferase. Taurus_UMD|evm.model.AC_000176.1.975 Q67FW5 B3GNL_HUMAN 89.712 0.991803 0.6759 B3GNTL1 - UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 - Homo sapiens (Human) - B3GNTL1 gene Putative glycosyltransferase. Taurus_UMD|evm.model.AC_000176.1.977 Q9H479 FN3K_HUMAN 90.615 0.993548 1.00324 FN3K - Fructosamine-3-kinase - Homo sapiens (Human) - FN3K gene Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, PubMed:11975663). Involved in intracellular deglycation in erythrocytes (PubMed:11975663). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848). Taurus_UMD|evm.model.AC_000176.1.978 Q8K274 KT3K_MOUSE 85.279 0.984925 0.644013 Fn3krp - Ketosamine-3-kinase - Mus musculus (Mouse) - Fn3krp gene Ketosamine-3-kinase involved in protein deglycation by mediating phosphorylation of ribuloselysine and psicoselysine on glycated proteins, to generate ribuloselysine-3 phosphate and psicoselysine-3 phosphate, respectively (PubMed:14633848). Ribuloselysine-3 phosphate and psicoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:14633848). Not able to phosphorylate fructoselysine (PubMed:14633848). Taurus_UMD|evm.model.AC_000176.1.979 Q12829 RB40B_HUMAN 89.568 0.992832 1.0036 RAB40B - Ras-related protein Rab-40B - Homo sapiens (Human) - RAB40B gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000176.1.980 Q8MIK9 PP14B_PIG 88.889 0.507772 1.31293 PPP1R14B - Protein phosphatase 1 regulatory subunit 14B - Sus scrofa (Pig) - PPP1R14B gene Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity). Taurus_UMD|evm.model.AC_000176.1.981 Q5MNZ6 WIPI3_HUMAN 98.837 0.994203 1.00291 WDR45B - WD repeat domain phosphoinositide-interacting protein 3 - Homo sapiens (Human) - WDR45B gene Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 (PubMed:28561066). In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway (PubMed:28503735). Taurus_UMD|evm.model.AC_000176.1.982 Q3UCQ1 FOXK2_MOUSE 83.779 0.969325 0.751152 Foxk2 - Forkhead box protein K2 - Mus musculus (Mouse) - Foxk2 gene Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (PubMed:25402684, PubMed:29861159, PubMed:30700909). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:25402684, PubMed:29861159, PubMed:30700909). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (PubMed:30700909). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (PubMed:30700909). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (PubMed:30700909). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (PubMed:25402684). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (By similarity). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (By similarity). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (By similarity). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (By similarity). Taurus_UMD|evm.model.AC_000176.1.983 Q3T114 RIDA_BOVIN 94.891 0.985507 1.0073 RIDA - 2-iminobutanoate/2-iminopropanoate deaminase - Bos taurus (Bovine) - RIDA gene Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. Taurus_UMD|evm.model.AC_000176.1.984 Q9UHQ1 NARF_HUMAN 83.991 0.995624 1.00219 NARF - Nuclear prelamin A recognition factor - Homo sapiens (Human) - NARF gene lamin filament, nuclear lamina, nuclear lumen, nucleolus, nucleoplasm, lamin binding Taurus_UMD|evm.model.AC_000176.1.985 Q3SZM3 CYBC1_BOVIN 100.000 0.989362 1.00535 CYBC1 - Cytochrome b-245 chaperone 1 - Bos taurus (Bovine) - CYBC1 gene Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (By similarity). Controls the phagocyte respiratory burst and is essential for innate immunity (By similarity). Taurus_UMD|evm.model.AC_000176.1.986 A6QNR0 HEXD_BOVIN 100.000 0.716667 1.38728 HEXD - Hexosaminidase D - Bos taurus (Bovine) - HEXD gene Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates. Taurus_UMD|evm.model.AC_000176.1.987 Q6PK18 OGFD3_HUMAN 83.648 0.990506 0.990596 OGFOD3 - 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 - Homo sapiens (Human) - OGFOD3 gene membrane Taurus_UMD|evm.model.AC_000176.1.988 P49220 UR2R_BOVIN 99.740 0.994805 1.0026 UTS2R - Urotensin-2 receptor - Bos taurus (Bovine) - UTS2R gene High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system (By similarity). Taurus_UMD|evm.model.AC_000176.1.989 Q8NA77 TEX19_HUMAN 65.625 0.451705 2.14634 TEX19 - Testis-expressed protein 19 - Homo sapiens (Human) - TEX19 gene Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization (PubMed:28806172). Taurus_UMD|evm.model.AC_000176.1.991 Q8NA77 TEX19_HUMAN 70.552 0.460227 2.14634 TEX19 - Testis-expressed protein 19 - Homo sapiens (Human) - TEX19 gene Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization (PubMed:28806172). Taurus_UMD|evm.model.AC_000176.1.992 Q8WVN6 SCTM1_HUMAN 53.125 0.439024 1.15726 SECTM1 - Secreted and transmembrane protein 1 precursor - Homo sapiens (Human) - SECTM1 gene May be involved in thymocyte signaling. Taurus_UMD|evm.model.AC_000176.1.993 P50283 CD7_MOUSE 54.787 0.916256 0.966667 Cd7 - T-cell antigen CD7 precursor - Mus musculus (Mouse) - Cd7 gene Not yet known. Taurus_UMD|evm.model.AC_000176.1.994 P48730 KC1D_HUMAN 97.816 0.958042 1.03373 CSNK1D - Casein kinase I isoform delta - Homo sapiens (Human) - CSNK1D gene Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. Taurus_UMD|evm.model.AC_000176.1.995 O35910 MOT4_RAT 89.384 0.934959 1.04459 Slc16a3 - Monocarboxylate transporter 4 - Rattus norvegicus (Rat) - Slc16a3 gene Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). Taurus_UMD|evm.model.AC_000176.1.996 Q2TAC2 CCD57_HUMAN 68.583 0.712329 1.11694 CCDC57 - Coiled-coil domain-containing protein 57 - Homo sapiens (Human) - CCDC57 gene Pleiotropic regulator of centriole duplication, mitosis, and ciliogenesis. Critical interface between centrosome and microtubule-mediated cellular processes. Centriole duplication protein required for recruitment of CEP63, CEP152, and PLK4 to the centrosome. Independent of its centrosomal targeting, localizes to and interacts with microtubules and regulates microtubule nucleation, stability, and mitotic progression. Taurus_UMD|evm.model.AC_000176.1.998 Q71SP7 FAS_BOVIN 98.569 0.994856 1.00557 FASN - Fatty acid synthase - Bos taurus (Bovine) - FASN gene Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. Taurus_UMD|evm.model.AC_000176.1.999 Q8C2P3 DUS1L_MOUSE 97.744 0.198496 1.4 Dus1l - tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like - Mus musculus (Mouse) - Dus1l gene Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Taurus_UMD|evm.model.AC_000176.1.1000 Q99LD4 CSN1_MOUSE 98.938 0.967078 1.03185 Gps1 - COP9 signalosome complex subunit 1 - Mus musculus (Mouse) - Gps1 gene Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction (By similarity). Taurus_UMD|evm.model.AC_000176.1.1001 Q9Y644 RFNG_HUMAN 91.139 0.746835 0.954683 RFNG - Beta-1,3-N-acetylglucosaminyltransferase radical fringe - Homo sapiens (Human) - RFNG gene Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis. Taurus_UMD|evm.model.AC_000176.1.1002 P08074 CBR2_MOUSE 89.344 0.991837 1.0041 Cbr2 - Carbonyl reductase [NADPH] 2 - Mus musculus (Mouse) - Cbr2 gene May function in the pulmonary metabolism of endogenous carbonyl compounds, such as aliphatic aldehydes and ketones derived from lipid peroxidation, 3-ketosteroids and fatty aldehydes, as well as in xenobiotic metabolism. Taurus_UMD|evm.model.AC_000176.1.1003 Q1JP75 DCXR_BOVIN 100.000 0.991837 1.0041 DCXR - L-xylulose reductase - Bos taurus (Bovine) - DCXR gene Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules (By similarity). Taurus_UMD|evm.model.AC_000176.1.1004 P60764 RAC3_MOUSE 100.000 0.986577 0.776042 Rac3 - Ras-related C3 botulinum toxin substrate 3 precursor - Mus musculus (Mouse) - Rac3 gene Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. Taurus_UMD|evm.model.AC_000176.1.1005 Q96CN5 LRC45_HUMAN 81.575 0.997033 1.00597 LRRC45 - Leucine-rich repeat-containing protein 45 - Homo sapiens (Human) - LRRC45 gene Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. Taurus_UMD|evm.model.AC_000176.1.1006 Q2NKU0 CENPX_BOVIN 98.571 0.526718 1.65823 CENPX - Centromere protein X - Bos taurus (Bovine) - CENPX gene DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own. Taurus_UMD|evm.model.AC_000176.1.1007 Q8VBT9 ASPC1_MOUSE 85.973 0.866142 0.461818 Aspscr1 - Tether containing UBX domain for GLUT4 - Mus musculus (Mouse) - Aspscr1 gene Enhances VCP methylation catalyzed by VCPKMT (By similarity). Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Taurus_UMD|evm.model.AC_000176.1.1008 Q8VBT9 ASPC1_MOUSE 64.242 0.483776 0.616364 Aspscr1 - Tether containing UBX domain for GLUT4 - Mus musculus (Mouse) - Aspscr1 gene Enhances VCP methylation catalyzed by VCPKMT (By similarity). Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Taurus_UMD|evm.model.AC_000176.1.1009 Q9BZE9 ASPC1_HUMAN 92.982 0.896825 0.227848 ASPSCR1 - Tether containing UBX domain for GLUT4 - Homo sapiens (Human) - ASPSCR1 gene Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT. Taurus_UMD|evm.model.AC_000176.1.1010 Q6P988 NOTUM_HUMAN 93.651 0.753012 0.334677 NOTUM - Palmitoleoyl-protein carboxylesterase NOTUM precursor - Homo sapiens (Human) - NOTUM gene Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175). Taurus_UMD|evm.model.AC_000176.1.1011 Q8R116 NOTUM_MOUSE 93.373 0.863874 0.379722 Notum - Palmitoleoyl-protein carboxylesterase NOTUM precursor - Mus musculus (Mouse) - Notum gene Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. Taurus_UMD|evm.model.AC_000176.1.1012 Q08DL4 MADL2_BOVIN 99.674 0.993506 1.00326 MYADML2 - Myeloid-associated differentiation marker-like protein 2 - Bos taurus (Bovine) - MYADML2 gene Taurus_UMD|evm.model.AC_000176.1.1013 Q58DT4 P5CR1_BOVIN 100.000 0.993769 1.00313 PYCR1 - Pyrroline-5-carboxylate reductase 1, mitochondrial - Bos taurus (Bovine) - PYCR1 gene Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. Taurus_UMD|evm.model.AC_000176.1.1014 O54790 MAFG_MOUSE 100.000 0.98773 1.00617 Mafg - Transcription factor MafG - Mus musculus (Mouse) - Mafg gene Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:16738329, PubMed:9679061). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:16738329, PubMed:9679061). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NFE2L2. Activates globin gene expression when associated with NFE2L2 (By similarity). May be involved in signal transduction of extracellular H(+) (By similarity). Taurus_UMD|evm.model.AC_000176.1.1015 Q0P595 SIR7_BOVIN 100.000 0.947743 1.0525 SIRT7 - NAD-dependent protein deacetylase sirtuin-7 - Bos taurus (Bovine) - SIRT7 gene NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase and deglutarylase), depending on the context. Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors; SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. Also able to mediate deacetylation of histone H3 at 'Lys-36' (H3K36Ac) in the context of nucleosomes. Also mediates deacetylation of non-histone proteins, such as ATM, CDK9, DDX21, DDB1, FBL, FKBP5/FKBP51, GABPB1, RAN, RRP9/U3-55K and POLR1E/PAF53. Enriched in nucleolus where it stimulates transcription activity of the RNA polymerase I complex. Acts by mediating the deacetylation of the RNA polymerase I subunit POLR1E/PAF53, thereby promoting the association of RNA polymerase I with the rDNA promoter region and coding region. In response to metabolic stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased RNA polymerase I transcription. Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis. Promotes pre-ribosomal RNA (pre-rRNA) cleavage at the 5'-terminal processing site by mediating deacetylation of RRP9/U3-55K, a core subunit of the U3 snoRNP complex. Mediates 'Lys-37' deacetylation of Ran, thereby regulating the nuclear export of NF-kappa-B subunit RELA/p65. Acts as a regulator of DNA damage repair by mediating deacetylation of ATM during the late stages of DNA damage response, promoting ATM dephosphorylation and deactivation. Suppresses the activity of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes by mediating deacetylation of DDB1, which prevents the interaction between DDB1 and CUL4 (CUL4A or CUL4B). Activates RNA polymerase II transcription by mediating deacetylation of CDK9, thereby promoting 'Ser-2' phosphorylation of the C-terminal domain (CTD) of RNA polymerase II. Deacetylates FBL, promoting histone-glutamine methyltransferase activity of FBL (By similarity). Acts as a regulator of mitochondrial function by catalyzing deacetylation of GABPB1 (By similarity). Regulates Akt/AKT1 activity by mediating deacetylation of FKBP5/FKBP51. Required to prevent R-loop-associated DNA damage and transcription-associated genomic instability by mediating deacetylation and subsequent activation of DDX21, thereby overcoming R-loop-mediated stalling of RNA polymerases. In addition to protein deacetylase activity, also acts as protein-lysine deacylase (By similarity). Acts as a protein depropionylase by mediating depropionylation of Osterix (SP7), thereby regulating bone formation by osteoblasts (By similarity). Acts as a histone deglutarylase by mediating deglutarylation of histone H4 on 'Lys-91' (H4K91glu); a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Acts as a histone desuccinylase: in response to DNA damage, recruited to DNA double-strand breaks (DSBs) and catalyzes desuccinylation of histone H3 on 'Lys-122' (H3K122succ), thereby promoting chromatin condensation and DSB repair (By similarity). Also promotes DSB repair by promoting H3K18Ac deacetylation, regulating non-homologous end joining (NHEJ). Along with its role in DNA repair, required for chromosome synapsis during prophase I of female meiosis by catalyzing H3K18Ac deacetylation (By similarity). Involved in transcriptional repression of LINE-1 retrotransposon via H3K18Ac deacetylation, and promotes their association with the nuclear lamina. Required to stabilize ribosomal DNA (rDNA) heterochromatin and prevent cellular senescence induced by rDNA instability (By similarity). Acts as a negative regulator of SIRT1 by preventing autodeacetylation of SIRT1, restricting SIRT1 deacetylase activity (By similarity). Taurus_UMD|evm.model.AC_000176.1.1016 Q5EA75 PCY2_BOVIN 95.577 0.995098 1.04884 PCYT2 - Ethanolamine-phosphate cytidylyltransferase - Bos taurus (Bovine) - PCYT2 gene Ethanolamine-phosphate cytidylyltransferase that catalyzes the second step in the synthesis of phosphatidylethanolamine (PE) from ethanolamine via the CDP-ethanolamine pathway. Phosphatidylethanolamine is a dominant inner-leaflet phospholipid in cell membranes, where it plays a role in membrane function by structurally stabilizing membrane-anchored proteins, and participates in important cellular processes such as cell division, cell fusion, blood coagulation, and apoptosis. Taurus_UMD|evm.model.AC_000176.1.1017 Q8MJV4 NPB_BOVIN 100.000 0.98374 1.0082 NPB - Neuropeptide B precursor - Bos taurus (Bovine) - NPB gene May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. Taurus_UMD|evm.model.AC_000176.1.1018 Q3ZCF6 APC11_BOVIN 100.000 0.976471 1.0119 ANAPC11 - Anaphase-promoting complex subunit 11 - Bos taurus (Bovine) - ANAPC11 gene Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). Taurus_UMD|evm.model.AC_000176.1.1019 Q3T0I4 THOC4_BOVIN 100.000 0.992248 1.00389 ALYREF - THO complex subunit 4 - Bos taurus (Bovine) - ALYREF gene Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability. Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling. Taurus_UMD|evm.model.AC_000176.1.1020 P19803 GDIR1_BOVIN 100.000 0.676667 1.47059 ARHGDIA - Rho GDP-dissociation inhibitor 1 - Bos taurus (Bovine) - ARHGDIA gene Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. Taurus_UMD|evm.model.AC_000176.1.1021 Q2NKS3 PSMG3_BOVIN 90.323 0.403974 1.2377 PSMG3 - Proteasome assembly chaperone 3 - Bos taurus (Bovine) - PSMG3 gene Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes. Taurus_UMD|evm.model.AC_000176.1.1022 P05307 PDIA1_BOVIN 99.608 0.899293 1.1098 P4HB - Protein disulfide-isomerase precursor - Bos taurus (Bovine) - P4HB gene This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. Taurus_UMD|evm.model.AC_000176.1.1023 Q9D119 PPR27_MOUSE 95.455 0.987097 1.00649 Ppp1r27 - Protein phosphatase 1 regulatory subunit 27 - Mus musculus (Mouse) - Ppp1r27 gene Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. Taurus_UMD|evm.model.AC_000176.1.1024 A8E4M4 MCRI1_BOVIN 97.938 0.8 1.23711 MCRIP1 - Mapk-regulated corepressor-interacting protein 1 - Bos taurus (Bovine) - MCRIP1 gene The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition. Taurus_UMD|evm.model.AC_000176.1.1025 P47871 GLR_HUMAN 84.583 0.99375 1.00629 GCGR - Glucagon receptor precursor - Homo sapiens (Human) - GCGR gene G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000176.1.1026 P62907 RL10A_RAT 81.429 0.8625 0.368664 Rpl10a - 60S ribosomal protein L10a - Rattus norvegicus (Rat) - Rpl10a gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000176.1.1027 Q9UBX3 DIC_HUMAN 90.592 0.993056 1.00348 SLC25A10 - Mitochondrial dicarboxylate carrier - Homo sapiens (Human) - SLC25A10 gene Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane. Taurus_UMD|evm.model.AC_000176.1.1028 Q7YR75 RM12_BOVIN 100.000 0.98995 1.00505 MRPL12 - 39S ribosomal protein L12, mitochondrial precursor - Bos taurus (Bovine) - MRPL12 gene As a component of the mitochondrial large ribosomal subunit, it plays a role in mitochondrial translation. Associates with mitochondrial RNA polymerase to activate transcription. Taurus_UMD|evm.model.AC_000176.1.1029 Q0V8S0 HGS_BOVIN 100.000 0.997429 1.00129 HGS - Hepatocyte growth factor-regulated tyrosine kinase substrate - Bos taurus (Bovine) - HGS gene Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). Taurus_UMD|evm.model.AC_000176.1.1030 Q0P5N6 ARL16_HUMAN 74.874 0.985075 1.0203 ARL16 - ADP-ribosylation factor-like protein 16 - Homo sapiens (Human) - ARL16 gene Taurus_UMD|evm.model.AC_000176.1.1031 Q17QR4 CC137_BOVIN 100.000 0.993174 1.00342 CCDC137 - Coiled-coil domain-containing protein 137 - Bos taurus (Bovine) - CCDC137 gene chromosome Taurus_UMD|evm.model.AC_000176.1.1032 A7YVI8 OXLD1_BOVIN 100.000 0.987013 1.00654 OXLD1 - Oxidoreductase-like domain-containing protein 1 - Bos taurus (Bovine) - OXLD1 gene Taurus_UMD|evm.model.AC_000176.1.1033 P04972 CNRG_BOVIN 100.000 0.977273 1.01149 PDE6G - Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma - Bos taurus (Bovine) - PDE6G gene Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. Taurus_UMD|evm.model.AC_000176.1.1034 Q9H1Z9 TSN10_HUMAN 70.000 0.796143 1.02254 TSPAN10 - Tetraspanin-10 - Homo sapiens (Human) - TSPAN10 gene Regulates maturation of the transmembrane metalloprotease ADAM10. Taurus_UMD|evm.model.AC_000176.1.1035 P60670 NPL4_MOUSE 97.533 0.996716 1.00164 Nploc4 - Nuclear protein localization protein 4 homolog - Mus musculus (Mouse) - Nploc4 gene The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (By similarity). Taurus_UMD|evm.model.AC_000176.1.1036 Q0VG06 FP100_HUMAN 72.778 0.997727 0.998865 FAAP100 - Fanconi anemia core complex-associated protein 100 - Homo sapiens (Human) - FAAP100 gene Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Taurus_UMD|evm.model.AC_000176.1.1037 O18728 FSCN2_BOVIN 100.000 0.995943 1.00203 FSCN2 - Fascin-2 - Bos taurus (Bovine) - FSCN2 gene Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Taurus_UMD|evm.model.AC_000176.1.1039 A2BDB0 ACTG_XENLA 100.000 0.994681 1.00267 actg1 - Actin, cytoplasmic 2 - Xenopus laevis (African clawed frog) - actg1 gene Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Taurus_UMD|evm.model.AC_000176.1.1040 Q9P281 BAHC1_HUMAN 87.179 0.995699 0.176203 BAHCC1 - BAH and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - BAHCC1 gene Taurus_UMD|evm.model.AC_000176.1.1041 Q9P281 BAHC1_HUMAN 81.520 0.940828 0.192118 BAHCC1 - BAH and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - BAHCC1 gene Taurus_UMD|evm.model.AC_000176.1.1042 Q9P281 BAHC1_HUMAN 84.462 0.16805 0.547935 BAHCC1 - BAH and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - BAHCC1 gene Taurus_UMD|evm.model.AC_000176.1.1043 Q5RC98 S38AA_PONAB 71.543 0.997227 0.96521 SLC38A10 - Putative sodium-coupled neutral amino acid transporter 10 - Pongo abelii (Sumatran orangutan) - SLC38A10 gene Putative sodium-dependent amino acid/proton antiporter. Taurus_UMD|evm.model.AC_000176.1.1044 A1L188 NDUF8_HUMAN 90.769 0.48855 1.77027 NDUFAF8 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 - Homo sapiens (Human) - NDUFAF8 gene Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) (PubMed:27499296). Required to stabilize NDUFAF5 (PubMed:27499296). Taurus_UMD|evm.model.AC_000176.1.1045 Q96N21 AP4AT_HUMAN 82.857 0.290484 1.14095 TEPSIN - AP-4 complex accessory subunit Tepsin - Homo sapiens (Human) - TEPSIN gene Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. Taurus_UMD|evm.model.AC_000176.1.1046 Q62036 CP131_MOUSE 73.699 0.989652 1.00283 Cep131 - Centrosomal protein of 131 kDa - Mus musculus (Mouse) - Cep131 gene Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner. Acts also as a negative regulator of BBSome ciliary trafficking (By similarity). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (PubMed:24415959). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability and centriole duplication in non-ciliogenic cells (By similarity). Involved in centriole duplication (PubMed:26297806). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (By similarity). Essential for maintaining proper centriolar satellite integrity (By similarity). Taurus_UMD|evm.model.AC_000176.1.1047 Q6ZMQ8 LMTK1_HUMAN 75.393 0.99854 0.997089 AATK - Serine/threonine-protein kinase LMTK1 - Homo sapiens (Human) - AATK gene May be involved in neuronal differentiation. Taurus_UMD|evm.model.AC_000176.1.1048 Q5EAD0 BAIP2_BOVIN 100.000 0.953358 1.02879 BAIAP2 - Brain-specific angiogenesis inhibitor 1-associated protein 2 - Bos taurus (Bovine) - BAIAP2 gene Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions (By similarity). Taurus_UMD|evm.model.AC_000176.1.1049 Q96FZ7 CHMP6_HUMAN 92.537 0.990099 1.00498 CHMP6 - Charged multivesicular body protein 6 - Homo sapiens (Human) - CHMP6 gene Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes. Taurus_UMD|evm.model.AC_000176.1.1050 Q8K4Q0 RPTOR_MOUSE 97.079 0.998503 1.00075 Rptor - Regulatory-associated protein of mTOR - Mus musculus (Mouse) - Rptor gene Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis. mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (PubMed:33495318). Taurus_UMD|evm.model.AC_000176.1.1051 Q62443 NPTX1_MOUSE 97.454 0.995381 1.00231 Nptx1 - Neuronal pentraxin-1 precursor - Mus musculus (Mouse) - Nptx1 gene May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. Taurus_UMD|evm.model.AC_000176.1.1053 Q8C9A2 ENDOV_MOUSE 79.783 0.919732 0.884615 Endov - Endonuclease V - Mus musculus (Mouse) - Endov gene Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures. Taurus_UMD|evm.model.AC_000176.1.1054 Q63HN8 RN213_HUMAN 69.216 0.997514 1.00442 RNF213 - E3 ubiquitin-protein ligase RNF213 - Homo sapiens (Human) - RNF213 gene E3 ubiquitin-protein ligase involved in angiogenesis (PubMed:21799892, PubMed:26278786, PubMed:26766444, PubMed:26126547). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity (PubMed:24658080, PubMed:26126547). Taurus_UMD|evm.model.AC_000176.1.1056 Q63HN8 RN213_HUMAN 70.138 0.98799 0.959478 RNF213 - E3 ubiquitin-protein ligase RNF213 - Homo sapiens (Human) - RNF213 gene E3 ubiquitin-protein ligase involved in angiogenesis (PubMed:21799892, PubMed:26278786, PubMed:26766444, PubMed:26126547). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity (PubMed:24658080, PubMed:26126547). Taurus_UMD|evm.model.AC_000176.1.1057 Q58DD2 S2611_BOVIN 100.000 0.996683 1.00166 SLC26A11 - Sodium-independent sulfate anion transporter - Bos taurus (Bovine) - SLC26A11 gene Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC). Taurus_UMD|evm.model.AC_000176.1.1058 P51688 SPHM_HUMAN 87.976 0.98419 1.00797 SGSH - N-sulphoglucosamine sulphohydrolase precursor - Homo sapiens (Human) - SGSH gene Catalyzes a step in lysosomal heparan sulfate degradation. Taurus_UMD|evm.model.AC_000176.1.1059 Q9BXL6 CAR14_HUMAN 78.365 0.997998 0.99502 CARD14 - Caspase recruitment domain-containing protein 14 - Homo sapiens (Human) - CARD14 gene Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27113748, PubMed:27071417). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Taurus_UMD|evm.model.AC_000176.1.1060 Q3B8Q2 IF4A3_RAT 100.000 0.995146 1.00243 Eif4a3 - Eukaryotic initiation factor 4A-III - Rattus norvegicus (Rat) - Eif4a3 gene ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Involved in craniofacial development. Taurus_UMD|evm.model.AC_000176.1.1061 Q9MYM4 LYAG_BOVIN 100.000 0.455696 2.1921 GAA - Lysosomal alpha-glucosidase precursor - Bos taurus (Bovine) - GAA gene Essential for the degradation of glycogen in lysosomes (PubMed:10723725). Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans. Taurus_UMD|evm.model.AC_000176.1.1062 Q8TBP0 TBC16_HUMAN 89.193 0.997396 1.0013 TBC1D16 - TBC1 domain family member 16 - Homo sapiens (Human) - TBC1D16 gene May act as a GTPase-activating protein for Rab family protein(s). Taurus_UMD|evm.model.AC_000176.1.1063 O55187 CBX4_MOUSE 96.667 0.619171 0.700544 Cbx4 - E3 SUMO-protein ligase CBX4 - Mus musculus (Mouse) - Cbx4 gene E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Taurus_UMD|evm.model.AC_000176.1.1064 Q9HC52 CBX8_HUMAN 90.385 0.994334 0.907455 CBX8 - Chromobox protein homolog 8 - Homo sapiens (Human) - CBX8 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Taurus_UMD|evm.model.AC_000176.1.1065 Q14781 CBX2_HUMAN 86.278 0.996234 0.99812 CBX2 - Chromobox protein homolog 2 - Homo sapiens (Human) - CBX2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780). Taurus_UMD|evm.model.AC_000176.1.1066 Q5EZ72 ENPP7_RAT 79.529 0.944321 1.02278 Enpp7 - Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 precursor - Rattus norvegicus (Rat) - Enpp7 gene Choline-specific phosphodiesterase that hydrolyzes sphingomyelin (SM) releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract (PubMed:16255717, PubMed:15708357). Has also phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation. Does not have nucleotide pyrophosphatase activity (PubMed:16255717). May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (By similarity). Taurus_UMD|evm.model.AC_000176.1.1070 A6NFN3 RFOX3_HUMAN 97.436 0.99361 1.00321 RBFOX3 - RNA binding protein fox-1 homolog 3 - Homo sapiens (Human) - RBFOX3 gene Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD). Taurus_UMD|evm.model.AC_000176.1.1071 Q8NFI3 ENASE_HUMAN 78.706 0.994565 0.990579 ENGASE - Cytosolic endo-beta-N-acetylglucosaminidase - Homo sapiens (Human) - ENGASE gene Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol. Taurus_UMD|evm.model.AC_000176.1.1072 Q9BXJ1 C1QT1_HUMAN 84.698 0.992857 0.996441 C1QTNF1 - Complement C1q tumor necrosis factor-related protein 1 precursor - Homo sapiens (Human) - C1QTNF1 gene extracellular space, integral component of plasma membrane, collagen binding, negative regulation of platelet activation, negative regulation of platelet aggregation, positive regulation of aldosterone secretion, positive regulation of cytosolic calcium ion concentration, positive regulation of gene expression Taurus_UMD|evm.model.AC_000176.1.1073 Q8WVQ1 CANT1_HUMAN 88.030 0.860215 1.1596 CANT1 - Soluble calcium-activated nucleotidase 1 - Homo sapiens (Human) - CANT1 gene Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15248776, PubMed:15006348, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336). Taurus_UMD|evm.model.AC_000176.1.1074 A7E3W2 LG3BP_BOVIN 100.000 0.996403 1.0018 LGALS3BP - Galectin-3-binding protein precursor - Bos taurus (Bovine) - LGALS3BP gene Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity). Taurus_UMD|evm.model.AC_000176.1.1075 Q9TRZ7 TIMP2_RABIT 99.485 0.873303 1.13918 TIMP2 - Metalloproteinase inhibitor 2 - Oryctolagus cuniculus (Rabbit) - TIMP2 gene Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Taurus_UMD|evm.model.AC_000176.1.1076 Q9P275 UBP36_HUMAN 71.290 0.998185 0.9813 USP36 - Ubiquitin carboxyl-terminal hydrolase 36 - Homo sapiens (Human) - USP36 gene Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634, PubMed:19208757, PubMed:22902402). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Taurus_UMD|evm.model.AC_000176.1.1077 Q15438 CYH1_HUMAN 96.725 0.861607 1.12563 CYTH1 - Cytohesin-1 - Homo sapiens (Human) - CYTH1 gene Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. Taurus_UMD|evm.model.AC_000176.1.1078 Q9UFH2 DYH17_HUMAN 92.158 0.999552 1.00045 DNAH17 - Dynein axonemal heavy chain 17 - Homo sapiens (Human) - DNAH17 gene Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (Probable). Plays a major role in sperm motility, implicated in sperm flagellar assembly and beating (PubMed:31178125). Taurus_UMD|evm.model.AC_000176.1.1079 Q2KJ28 PGPS1_BOVIN 100.000 0.996409 1.0018 PGS1 - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial precursor - Bos taurus (Bovine) - PGS1 gene Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin. Taurus_UMD|evm.model.AC_000176.1.1080 Q9BEG9 SOCS3_BOVIN 100.000 0.991304 1.00437 SOCS3 - Suppressor of cytokine signaling 3 - Bos taurus (Bovine) - SOCS3 gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Taurus_UMD|evm.model.AC_000176.1.1081 O07051 LTAA_AERJA 47.603 0.740458 1.16272 ltaA - L-allo-threonine aldolase - Aeromonas jandaei - ltaA gene Stereospecifically catalyzes the interconversion of L-allo-threonine and glycine. Taurus_UMD|evm.model.AC_000176.1.1082 A6NFC5 TM235_HUMAN 80.226 0.807512 0.955157 TMEM235 - Transmembrane protein 235 precursor - Homo sapiens (Human) - TMEM235 gene apical plasma membrane Taurus_UMD|evm.model.AC_000176.1.1083 Q6J1J1 BIRC5_BOVIN 100.000 0.986014 1.00704 BIRC5 - Baculoviral IAP repeat-containing protein 5 - Bos taurus (Bovine) - BIRC5 gene Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (By similarity). Taurus_UMD|evm.model.AC_000176.1.1084 Q63HM1 KFA_HUMAN 78.289 0.986971 1.0132 AFMID - Kynurenine formamidase - Homo sapiens (Human) - AFMID gene Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. Taurus_UMD|evm.model.AC_000176.1.1085 A5D7R8 KITH_BOVIN 100.000 0.88764 1.12185 TK1 - Thymidine kinase, cytosolic - Bos taurus (Bovine) - TK1 gene thymidine kinase activity, zinc ion binding, thymidine metabolic process Taurus_UMD|evm.model.AC_000176.1.1086 A7E3W5 SNG2_BOVIN 100.000 0.991111 1.00446 SYNGR2 - Synaptogyrin-2 - Bos taurus (Bovine) - SYNGR2 gene May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. Taurus_UMD|evm.model.AC_000176.1.1087 Q8IU68 TMC8_HUMAN 81.743 0.990305 0.99449 TMC8 - Transmembrane channel-like protein 8 - Homo sapiens (Human) - TMC8 gene Probable ion channel. Taurus_UMD|evm.model.AC_000176.1.1088 Q7Z403 TMC6_HUMAN 77.551 0.950182 1.02236 TMC6 - Transmembrane channel-like protein 6 - Homo sapiens (Human) - TMC6 gene Probable ion channel. Taurus_UMD|evm.model.AC_000176.1.1089 Q9HCJ0 TNR6C_HUMAN 86.316 0.890439 1.14497 TNRC6C - Trinucleotide repeat-containing gene 6C protein - Homo sapiens (Human) - TNRC6C gene Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Taurus_UMD|evm.model.AC_000176.1.1093 Q9UHD8 SEPT9_HUMAN 93.226 0.965458 0.988055 SEPTIN9 - Septin-9 - Homo sapiens (Human) - SEPTIN9 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. Taurus_UMD|evm.model.AC_000176.1.1094 Q92503 S14L1_HUMAN 94.556 0.972067 1.0014 SEC14L1 - SEC14-like protein 1 - Homo sapiens (Human) - SEC14L1 gene May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608). Taurus_UMD|evm.model.AC_000176.1.1095 Q3V5L5 MGT5B_HUMAN 87.906 0.930412 0.979798 MGAT5B - Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B - Homo sapiens (Human) - MGAT5B gene Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway. Taurus_UMD|evm.model.AC_000176.1.1096 Q4R495 MFS11_MACFA 95.991 0.995556 1.00223 MFSD11 - UNC93-like protein MFSD11 - Macaca fascicularis (Crab-eating macaque) - MFSD11 gene Taurus_UMD|evm.model.AC_000176.1.1097 Q6PDU1 SRSF2_RAT 100.000 0.990991 1.00452 Srsf2 - Serine/arginine-rich splicing factor 2 - Rattus norvegicus (Rat) - Srsf2 gene Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity). Taurus_UMD|evm.model.AC_000176.1.1098 Q86XA0 MET23_HUMAN 78.440 0.977477 1.16842 METTL23 - Methyltransferase-like protein 23 - Homo sapiens (Human) - METTL23 gene Probable methyltransferase. Taurus_UMD|evm.model.AC_000176.1.1100 Q58DS6 JMJD6_BOVIN 100.000 0.968675 1.02978 JMJD6 - Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 - Bos taurus (Bovine) - JMJD6 gene Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation. Demethylates other arginine methylated-proteins such as ESR1. Has no histone lysine demethylase activity (By similarity). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (By similarity). Taurus_UMD|evm.model.AC_000176.1.1101 P84157 MXRA7_HUMAN 67.778 0.851852 0.926471 MXRA7 - Matrix-remodeling-associated protein 7 - Homo sapiens (Human) - MXRA7 gene collagen-containing extracellular matrix, endoplasmic reticulum Taurus_UMD|evm.model.AC_000176.1.1102 Q9QZ39 SIA7A_MOUSE 71.230 0.716194 1.13878 St6galnac1 - Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 - Mus musculus (Mouse) - St6galnac1 gene Transfers CMP-NeuAc with an alpha-2,6-linkage to the GalNAc residues of GalNAc-O-Ser/Thr, Gal-beta-1,3-GalNAc-O-Ser/Thr and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-O-Ser/Thr are substrates. Higher activity towards GalNAc-O-Ser/Thr. Taurus_UMD|evm.model.AC_000176.1.1103 Q9UJ37 SIA7B_HUMAN 81.067 0.994681 1.00535 ST6GALNAC2 - Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 - Homo sapiens (Human) - ST6GALNAC2 gene Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins. Taurus_UMD|evm.model.AC_000176.1.1104 Q8WWM9 CYGB_HUMAN 96.667 0.98895 0.952632 CYGB - Cytoglobin - Homo sapiens (Human) - CYGB gene May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer. Taurus_UMD|evm.model.AC_000176.1.1105 Q00M95 RHDF2_CANLF 93.630 0.997593 1.00484 RHBDF2 - Inactive rhomboid protein 2 - Canis lupus familiaris (Dog) - RHBDF2 gene Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. Taurus_UMD|evm.model.AC_000176.1.1106 O02785 SNAT_BOVIN 95.169 0.990385 1.00483 AANAT - Serotonin N-acetyltransferase - Bos taurus (Bovine) - AANAT gene Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. Taurus_UMD|evm.model.AC_000176.1.1107 O02785 SNAT_BOVIN 99.517 0.990385 1.00483 AANAT - Serotonin N-acetyltransferase - Bos taurus (Bovine) - AANAT gene Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. Taurus_UMD|evm.model.AC_000176.1.1108 Q9C0C9 UBE2O_HUMAN 95.375 0.96972 0.996904 UBE2O - (E3-independent) E2 ubiquitin-conjugating enzyme - Homo sapiens (Human) - UBE2O gene E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Taurus_UMD|evm.model.AC_000176.1.1109 Q9NYA1 SPHK1_HUMAN 87.629 0.820513 0.304688 SPHK1 - Sphingosine kinase 1 - Homo sapiens (Human) - SPHK1 gene Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol (PubMed:20577214, PubMed:23602659, PubMed:29662056, PubMed:24929359, PubMed:11923095). In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis (PubMed:16118219). Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling leading to IL17 secretion (PubMed:20577214). In response to TNF and in parallel to NF-kappa-B activation, negatively regulates RANTES induction through p38 MAPK signaling pathway (PubMed:23935096). Involved in endocytic membrane trafficking induced by sphingosine, recruited to dilate endosomes, also plays a role on later stages of endosomal maturation and membrane fusion independently of its kinase activity (PubMed:28049734, PubMed:24929359). In Purkinje cells, seems to be also involved in the regulation of autophagosome-lysosome fusion upon VEGFA (PubMed:25417698). Taurus_UMD|evm.model.AC_000176.1.1110 Q9NYA1 SPHK1_HUMAN 82.083 0.694767 0.895833 SPHK1 - Sphingosine kinase 1 - Homo sapiens (Human) - SPHK1 gene Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol (PubMed:20577214, PubMed:23602659, PubMed:29662056, PubMed:24929359, PubMed:11923095). In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis (PubMed:16118219). Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling leading to IL17 secretion (PubMed:20577214). In response to TNF and in parallel to NF-kappa-B activation, negatively regulates RANTES induction through p38 MAPK signaling pathway (PubMed:23935096). Involved in endocytic membrane trafficking induced by sphingosine, recruited to dilate endosomes, also plays a role on later stages of endosomal maturation and membrane fusion independently of its kinase activity (PubMed:28049734, PubMed:24929359). In Purkinje cells, seems to be also involved in the regulation of autophagosome-lysosome fusion upon VEGFA (PubMed:25417698). Taurus_UMD|evm.model.AC_000176.1.1111 Q08DW2 KPRA_BOVIN 100.000 0.919689 1.08427 PRPSAP1 - Phosphoribosyl pyrophosphate synthase-associated protein 1 - Bos taurus (Bovine) - PRPSAP1 gene Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis. Taurus_UMD|evm.model.AC_000176.1.1112 Q3V2A7 QRIC2_MOUSE 74.457 0.344053 2.78378 Qrich2 - Glutamine-rich protein 2 - Mus musculus (Mouse) - Qrich2 gene Has an essential role in the formation of sperm flagella and flagellar structure maintainance. It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility. Taurus_UMD|evm.model.AC_000176.1.1113 Q8IYN6 UBAD2_HUMAN 93.413 0.988095 1.02439 UBALD2 - UBA-like domain-containing protein 2 - Homo sapiens (Human) - UBALD2 gene Taurus_UMD|evm.model.AC_000176.1.1114 Q96PX1 RN157_HUMAN 92.319 0.944134 1.05449 RNF157 - E3 ubiquitin ligase RNF157 - Homo sapiens (Human) - RNF157 gene E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764). Taurus_UMD|evm.model.AC_000176.1.1115 Q92949 FOXJ1_HUMAN 95.724 0.995261 1.00238 FOXJ1 - Forkhead box protein J1 - Homo sapiens (Human) - FOXJ1 gene Transcription factor specifically required for the formation of motile cilia (PubMed:31630787). Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung. Taurus_UMD|evm.model.AC_000176.1.1116 Q9UPT5 EXOC7_HUMAN 92.653 0.997175 0.963265 EXOC7 - Exocyst complex component 7 - Homo sapiens (Human) - EXOC7 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). Taurus_UMD|evm.model.AC_000176.1.1117 O43603 GALR2_HUMAN 82.759 0.417288 1.73385 GALR2 - Galanin receptor type 2 - Homo sapiens (Human) - GALR2 gene Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). Taurus_UMD|evm.model.AC_000176.1.1119 Q00004 SRP68_CANLF 96.308 0.996795 1.00322 SRP68 - Signal recognition particle subunit SRP68 - Canis lupus familiaris (Dog) - SRP68 gene Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. Taurus_UMD|evm.model.AC_000176.1.1120 Q92817 EVPL_HUMAN 83.915 0.999017 1.00049 EVPL - Envoplakin - Homo sapiens (Human) - EVPL gene Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. Taurus_UMD|evm.model.AC_000176.1.1121 Q00526 CDK3_HUMAN 89.109 0.986928 1.00328 CDK3 - Cyclin-dependent kinase 3 - Homo sapiens (Human) - CDK3 gene Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. Taurus_UMD|evm.model.AC_000176.1.1122 Q86WV5 TEN1L_HUMAN 81.148 0.98374 1 TEN1 - CST complex subunit TEN1 - Homo sapiens (Human) - TEN1 gene Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097). Taurus_UMD|evm.model.AC_000176.1.1123 Q3SZP5 ACOX1_BOVIN 90.405 0.996965 0.998485 ACOX1 - Peroxisomal acyl-coenzyme A oxidase 1 - Bos taurus (Bovine) - ACOX1 gene Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Taurus_UMD|evm.model.AC_000176.1.1124 Q8TES7 FBF1_HUMAN 73.443 0.998214 0.988526 FBF1 - Fas-binding factor 1 - Homo sapiens (Human) - FBF1 gene Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. Taurus_UMD|evm.model.AC_000176.1.1125 Q3ZBF3 RM38_BOVIN 100.000 0.994751 1.00263 MRPL38 - 39S ribosomal protein L38, mitochondrial precursor - Bos taurus (Bovine) - MRPL38 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Taurus_UMD|evm.model.AC_000176.1.1126 Q6PJ69 TRI65_HUMAN 75.146 0.925319 1.0619 TRIM65 - Tripartite motif-containing protein 65 - Homo sapiens (Human) - TRIM65 gene cytosol, nucleoplasm, positive regulation of autophagy Taurus_UMD|evm.model.AC_000176.1.1127 Q96LD4 TRI47_HUMAN 90.308 0.996923 1.01881 TRIM47 - E3 ubiquitin-protein ligase TRIM47 - Homo sapiens (Human) - TRIM47 gene E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD. Taurus_UMD|evm.model.AC_000176.1.1128 Q969T9 WBP2_HUMAN 96.169 0.992366 1.00383 WBP2 - WW domain-binding protein 2 - Homo sapiens (Human) - WBP2 gene Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533). Required for YAP1 coactivation function on PGR activity (PubMed:16772533). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity). Taurus_UMD|evm.model.AC_000176.1.1129 Q70J99 UN13D_HUMAN 87.971 0.99725 1.00092 UNC13D - Protein unc-13 homolog D - Homo sapiens (Human) - UNC13D gene Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. Taurus_UMD|evm.model.AC_000176.1.1130 Q9C0B0 UNK_HUMAN 96.173 0.997497 0.98642 UNK - RING finger protein unkempt homolog - Homo sapiens (Human) - UNK gene Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). Taurus_UMD|evm.model.AC_000176.1.1131 P84246 H33_RABIT 100.000 0.985401 1.00735 H3-3A - Histone H3.3 - Oryctolagus cuniculus (Rabbit) - H3-3A gene Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000176.1.1132 A6H768 GALK1_BOVIN 99.237 0.994924 1.0051 GALK1 - Galactokinase - Bos taurus (Bovine) - GALK1 gene Major enzyme for galactose metabolism. Taurus_UMD|evm.model.AC_000176.1.1133 Q64632 ITB4_RAT 85.335 0.998882 0.990039 Itgb4 - Integrin beta-4 precursor - Rattus norvegicus (Rat) - Itgb4 gene Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. Taurus_UMD|evm.model.AC_000176.1.1134 Q9UHR5 S30BP_HUMAN 95.455 0.993528 1.00325 SAP30BP - SAP30-binding protein - Homo sapiens (Human) - SAP30BP gene Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes. Taurus_UMD|evm.model.AC_000176.1.1135 O94762 RECQ5_HUMAN 80.544 0.996964 0.996973 RECQL5 - ATP-dependent DNA helicase Q5 - Homo sapiens (Human) - RECQL5 gene Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. Taurus_UMD|evm.model.AC_000176.1.1136 Q96JP2 MY15B_HUMAN 70.217 0.47187 2.0098 MYO15B - Unconventional myosin-XVB - Homo sapiens (Human) - MYO15B gene Unknown, due to the absence of a functional motor domain. Taurus_UMD|evm.model.AC_000176.1.1137 Q6P1M3 L2GL2_HUMAN 88.834 0.997986 0.973529 LLGL2 - LLGL scribble cell polarity complex component 2 - Homo sapiens (Human) - LLGL2 gene Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. Taurus_UMD|evm.model.AC_000176.1.1138 Q7Z6J9 SEN54_HUMAN 83.239 0.996219 1.0057 TSEN54 - tRNA-splicing endonuclease subunit Sen54 - Homo sapiens (Human) - TSEN54 gene Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Taurus_UMD|evm.model.AC_000176.1.1139 Q8WXE0 CSKI2_HUMAN 89.200 0.998337 1.00083 CASKIN2 - Caskin-2 - Homo sapiens (Human) - CASKIN2 gene cytoplasm, membrane Taurus_UMD|evm.model.AC_000176.1.1140 Q12767 TMM94_HUMAN 93.906 0.998533 1.00516 TMEM94 - Transmembrane protein 94 - Homo sapiens (Human) - TMEM94 gene Taurus_UMD|evm.model.AC_000176.1.1141 P62994 GRB2_RAT 100.000 0.990826 1.00461 Grb2 - Growth factor receptor-bound protein 2 - Rattus norvegicus (Rat) - Grb2 gene Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Taurus_UMD|evm.model.AC_000176.1.1142 Q29RM1 TPC_BOVIN 100.000 0.99373 1.00314 SLC25A19 - Mitochondrial thiamine pyrophosphate carrier - Bos taurus (Bovine) - SLC25A19 gene Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria. Taurus_UMD|evm.model.AC_000176.1.1143 Q3ZC21 MI4GD_BOVIN 100.000 0.991031 1.0045 MIF4GD - MIF4G domain-containing protein - Bos taurus (Bovine) - MIF4GD gene Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity). Taurus_UMD|evm.model.AC_000176.1.1144 Q3T040 RT07_BOVIN 100.000 0.99177 1.00413 MRPS7 - 28S ribosomal protein S7, mitochondrial precursor - Bos taurus (Bovine) - MRPS7 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, ribosome, mRNA binding, rRNA binding, structural constituent of ribosome, mitochondrial translation, ribosomal small subunit assembly, translation Taurus_UMD|evm.model.AC_000176.1.1145 Q8BMI3 GGA3_MOUSE 81.843 0.997195 0.993036 Gga3 - ADP-ribosylation factor-binding protein GGA3 - Mus musculus (Mouse) - Gga3 gene Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (By similarity). Taurus_UMD|evm.model.AC_000176.1.1146 Q3ZC98 NUP85_BOVIN 100.000 0.996956 1.00152 NUP85 - Nuclear pore complex protein Nup85 - Bos taurus (Bovine) - NUP85 gene Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade. Involved in nephrogenesis. Taurus_UMD|evm.model.AC_000176.1.1147 P61959 SUMO2_RAT 98.876 0.733333 1.26316 Sumo2 - Small ubiquitin-related modifier 2 precursor - Rattus norvegicus (Rat) - Sumo2 gene Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity). Taurus_UMD|evm.model.AC_000176.1.1148 Q3T0T5 JUPI1_BOVIN 100.000 0.987097 1.00649 JPT1 - Jupiter microtubule associated homolog 1 - Bos taurus (Bovine) - JPT1 gene Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation. Taurus_UMD|evm.model.AC_000176.1.1149 Q8TCD5 NT5C_HUMAN 84.184 0.898618 1.0796 NT5C - 5'(3')-deoxyribonucleotidase, cytosolic type - Homo sapiens (Human) - NT5C gene Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. Taurus_UMD|evm.model.AC_000176.1.1150 Q9H6L4 ARMC7_HUMAN 86.294 0.984925 1.00505 ARMC7 - Armadillo repeat-containing protein 7 - Homo sapiens (Human) - ARMC7 gene Taurus_UMD|evm.model.AC_000176.1.1151 O15375 MOT6_HUMAN 73.548 0.993407 0.90099 SLC16A5 - Monocarboxylate transporter 6 - Homo sapiens (Human) - SLC16A5 gene Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). Taurus_UMD|evm.model.AC_000176.1.1152 Q14258 TRI25_HUMAN 34.574 0.306667 0.952381 TRIM25 - E3 ubiquitin/ISG15 ligase TRIM25 - Homo sapiens (Human) - TRIM25 gene Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1 (PubMed:17392790, PubMed:30193849). Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Taurus_UMD|evm.model.AC_000176.1.1153 Q14681 KCTD2_HUMAN 99.057 0.946188 0.847909 KCTD2 - BTB/POZ domain-containing protein KCTD2 - Homo sapiens (Human) - KCTD2 gene Cul3-RING ubiquitin ligase complex, cytoplasm, cullin family protein binding, protein-containing complex binding, proteasome-mediated ubiquitin-dependent protein catabolic process Taurus_UMD|evm.model.AC_000176.1.1154 P13620 ATP5H_BOVIN 100.000 0.987654 1.00621 ATP5PD - ATP synthase subunit d, mitochondrial - Bos taurus (Bovine) - ATP5PD gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Taurus_UMD|evm.model.AC_000176.1.1155 Q3T116 ICT1_BOVIN 100.000 0.990338 1.00485 MRPL58 - Peptidyl-tRNA hydrolase ICT1, mitochondrial precursor - Bos taurus (Bovine) - MRPL58 gene Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. Taurus_UMD|evm.model.AC_000176.1.1156 Q86X02 CDR2L_HUMAN 94.409 0.995699 1 CDR2L - Cerebellar degeneration-related protein 2-like - Homo sapiens (Human) - CDR2L gene identical protein binding Taurus_UMD|evm.model.AC_000176.1.1157 Q8IV36 HID1_HUMAN 93.782 0.997413 0.980964 HID1 - Protein HID1 - Homo sapiens (Human) - HID1 gene May play an important role in the development of cancers in a broad range of tissues. Taurus_UMD|evm.model.AC_000176.1.1158 Q7RTS5 OTOP3_HUMAN 84.574 0.9947 0.949664 OTOP3 - Proton channel OTOP3 - Homo sapiens (Human) - OTOP3 gene Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. Taurus_UMD|evm.model.AC_000176.1.1159 Q7RTS6 OTOP2_HUMAN 86.879 0.996454 1.00356 OTOP2 - Proton channel OTOP2 - Homo sapiens (Human) - OTOP2 gene Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. Taurus_UMD|evm.model.AC_000176.1.1160 Q495M9 USH1G_HUMAN 94.805 0.99568 1.00434 USH1G - Usher syndrome type-1G protein - Homo sapiens (Human) - USH1G gene Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Taurus_UMD|evm.model.AC_000176.1.1161 Q6Q311 RS25_SHEEP 90.400 0.983871 0.992 RPS25 - 40S ribosomal protein S25 - Ovis aries (Sheep) - RPS25 gene Taurus_UMD|evm.model.AC_000176.1.1162 A2VE15 FADS6_BOVIN 100.000 0.994169 1.00292 FADS6 - Fatty acid desaturase 6 - Bos taurus (Bovine) - FADS6 gene Taurus_UMD|evm.model.AC_000176.1.1163 P08165 ADRO_BOVIN 99.797 0.995943 1.00203 FDXR - NADPH:adrenodoxin oxidoreductase, mitochondrial precursor - Bos taurus (Bovine) - FDXR gene Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. Taurus_UMD|evm.model.AC_000176.1.1164 Q14957 NMDE3_HUMAN 88.808 0.998373 0.996756 GRIN2C - Glutamate receptor ionotropic, NMDA 2C precursor - Homo sapiens (Human) - GRIN2C gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Taurus_UMD|evm.model.AC_000176.1.1165 Q5RCV1 TM104_PONAB 84.708 0.995633 0.923387 TMEM104 - Transmembrane protein 104 - Pongo abelii (Sumatran orangutan) - TMEM104 gene Taurus_UMD|evm.model.AC_000176.1.1166 Q9BTE0 NAT9_HUMAN 87.923 0.990338 1 NAT9 - N-acetyltransferase 9 - Homo sapiens (Human) - NAT9 gene protein-containing complex, protein acetylation Taurus_UMD|evm.model.AC_000176.1.1167 Q3SZK8 NHRF1_BOVIN 100.000 0.99458 1.00272 SLC9A3R1 - Na(+)/H(+) exchange regulatory cofactor NHE-RF1 - Bos taurus (Bovine) - SLC9A3R1 gene Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Taurus_UMD|evm.model.AC_000176.1.1168 Q96AX2 RAB37_HUMAN 93.274 0.991071 1.00448 RAB37 - Ras-related protein Rab-37 precursor - Homo sapiens (Human) - RAB37 gene azurophil granule membrane, endoplasmic reticulum-Golgi intermediate compartment, endosome, Golgi apparatus, plasma membrane, specific granule membrane, neutrophil degranulation Taurus_UMD|evm.model.AC_000176.1.1169 Q29RR0 RAB26_BOVIN 65.714 0.453333 0.292969 RAB26 - Ras-related protein Rab-26 - Bos taurus (Bovine) - RAB26 gene Participates in exocrine secretion: regulates the secretion of acinar granules in the parotid gland. Taurus_UMD|evm.model.AC_000176.1.1170 Q6UXZ3 CLM5_HUMAN 56.296 0.358289 1.92784 CD300LD - CMRF35-like molecule 5 precursor - Homo sapiens (Human) - CD300LD gene plasma membrane, transmembrane signaling receptor activity, regulation of immune response Taurus_UMD|evm.model.AC_000176.1.1171 Q8TDQ1 CLM1_HUMAN 64.545 0.135572 2.77241 CD300LF - CMRF35-like molecule 1 precursor - Homo sapiens (Human) - CD300LF gene Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity). Taurus_UMD|evm.model.AC_000176.1.1172 A0A0K2S4Q6 CD3CH_HUMAN 58.738 0.919283 1.10945 CD300H - Protein CD300H precursor - Homo sapiens (Human) - CD300H gene May play an important role in innate immunity by mediating a signal for the production of a neutrophil chemoattractant. Taurus_UMD|evm.model.AC_000176.1.1173 Q08708 CLM6_HUMAN 51.786 0.986425 0.986607 CD300C - CMRF35-like molecule 6 precursor - Homo sapiens (Human) - CD300C gene integral component of plasma membrane, plasma membrane, transmembrane signaling receptor activity, cellular defense response, regulation of immune response Taurus_UMD|evm.model.AC_000176.1.1174 Q9UGN4 CLM8_HUMAN 57.500 0.490323 0.518395 CD300A - CMRF35-like molecule 8 precursor - Homo sapiens (Human) - CD300A gene Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923). Taurus_UMD|evm.model.AC_000176.1.1175 Q8TDQ1 CLM1_HUMAN 62.069 0.351852 0.558621 CD300LF - CMRF35-like molecule 1 precursor - Homo sapiens (Human) - CD300LF gene Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity). Taurus_UMD|evm.model.AC_000176.1.1176 Q08708 CLM6_HUMAN 53.906 0.413333 1.33929 CD300C - CMRF35-like molecule 6 precursor - Homo sapiens (Human) - CD300C gene integral component of plasma membrane, plasma membrane, transmembrane signaling receptor activity, cellular defense response, regulation of immune response Taurus_UMD|evm.model.AC_000176.1.1177 Q2YDG0 GPC5C_BOVIN 99.769 0.872727 1.11991 GPRC5C - G-protein coupled receptor family C group 5 member C precursor - Bos taurus (Bovine) - GPRC5C gene This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Taurus_UMD|evm.model.AC_000176.1.1178 Q7Z601 GP142_HUMAN 81.395 0.974432 0.761905 GPR142 - Probable G-protein coupled receptor 142 - Homo sapiens (Human) - GPR142 gene Orphan receptor. Taurus_UMD|evm.model.AC_000176.1.1179 Q9DB72 BTBDH_MOUSE 93.305 0.995825 1.00209 Btbd17 - BTB/POZ domain-containing protein 17 precursor - Mus musculus (Mouse) - Btbd17 gene Taurus_UMD|evm.model.AC_000176.1.1180 Q2TAC6 KIF19_HUMAN 78.128 0.99803 1.01703 KIF19 - Kinesin-like protein KIF19 - Homo sapiens (Human) - KIF19 gene Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips. Taurus_UMD|evm.model.AC_000176.1.1181 Q9GZS0 DNAI2_HUMAN 89.249 0.948136 1.01983 DNAI2 - Dynein axonemal intermediate chain 2 - Homo sapiens (Human) - DNAI2 gene Part of the dynein complex of respiratory cilia. Taurus_UMD|evm.model.AC_000176.1.1182 Q9BSA4 TTYH2_HUMAN 78.739 0.996396 1.03933 TTYH2 - Protein tweety homolog 2 - Homo sapiens (Human) - TTYH2 gene Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation. Taurus_UMD|evm.model.AC_000176.1.1183 P63174 RL38_RAT 100.000 0.971831 1.01429 Rpl38 - 60S ribosomal protein L38 - Rattus norvegicus (Rat) - Rpl38 gene cytosolic large ribosomal subunit, eukaryotic 80S initiation complex, polysomal ribosome, postsynaptic density, synapse, structural constituent of ribosome, 90S preribosome assembly, axial mesoderm development, cytoplasmic translation, middle ear morphogenesis Taurus_UMD|evm.model.AC_000176.1.1184 A6NE02 BTBDH_HUMAN 93.431 0.92517 0.307531 BTBD17 - BTB/POZ domain-containing protein 17 precursor - Homo sapiens (Human) - BTBD17 gene plasma membrane, negative regulation of viral genome replication, response to virus Taurus_UMD|evm.model.AC_000176.1.1186 Q58EX2 SDK2_HUMAN 91.564 0.441893 0.982505 SDK2 - Protein sidekick-2 precursor - Homo sapiens (Human) - SDK2 gene Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. Taurus_UMD|evm.model.AC_000176.1.1187 Q9H3Q1 BORG4_HUMAN 76.584 0.994253 0.977528 CDC42EP4 - Cdc42 effector protein 4 - Homo sapiens (Human) - CDC42EP4 gene Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. Taurus_UMD|evm.model.AC_000176.1.1188 Q9VPT8 CPSF4_DROME 60.000 0.36875 0.540541 Clp - Cleavage and polyadenylation specificity factor subunit 4 - Drosophila melanogaster (Fruit fly) - Clp gene Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity. Binds RNA polymers with a preference for G- and/or C-rich clusters. Binds single-stranded DNA non-specifically. Taurus_UMD|evm.model.AC_000176.1.1189 Q9BSJ5 CQ080_HUMAN 54.355 0.982111 0.917898 C17orf80 - Uncharacterized protein C17orf80 - Homo sapiens (Human) - C17orf80 gene extracellular exosome Taurus_UMD|evm.model.AC_000176.1.1190 Q969W3 F104A_HUMAN 82.065 0.978261 0.989247 FAM104A - Protein FAM104A - Homo sapiens (Human) - FAM104A gene Taurus_UMD|evm.model.AC_000176.1.1191 Q8WTW3 COG1_HUMAN 83.825 0.997963 1.00204 COG1 - Conserved oligomeric Golgi complex subunit 1 - Homo sapiens (Human) - COG1 gene Required for normal Golgi function. Taurus_UMD|evm.model.AC_000176.1.1193 P34993 SSR2_BOVIN 99.457 0.99458 1.00272 SSTR2 - Somatostatin receptor type 2 - Bos taurus (Bovine) - SSTR2 gene Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization (By similarity). Taurus_UMD|evm.model.AC_000176.1.1194 Q2YDD4 S39AB_BOVIN 97.947 0.99403 0.982405 SLC39A11 - Zinc transporter ZIP11 - Bos taurus (Bovine) - SLC39A11 gene Functions as a cellular zinc transporter. Taurus_UMD|evm.model.AC_000176.1.1198 F1LYL9 SOX9_RAT 87.773 0.78853 0.550296 Sox9 - Transcription factor SOX-9 - Rattus norvegicus (Rat) - Sox9 gene Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (By similarity). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:26150426). Also binds to some promoter regions (By similarity). Plays a central role in successive steps of chondrocyte differentiation (By similarity). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (By similarity). Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (By similarity). Controls epithelial branching during kidney development (By similarity). Taurus_UMD|evm.model.AC_000176.1.1206 O19182 KCNJ2_BOVIN 100.000 0.995327 1.00234 KCNJ2 - Inward rectifier potassium channel 2 - Bos taurus (Bovine) - KCNJ2 gene Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). Taurus_UMD|evm.model.AC_000176.1.1207 Q9NPI9 KCJ16_HUMAN 89.286 0.995249 1.00718 KCNJ16 - Inward rectifier potassium channel 16 - Homo sapiens (Human) - KCNJ16 gene Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201). Taurus_UMD|evm.model.AC_000176.1.1212 Q5E9X2 MP2K6_BOVIN 100.000 0.99403 1.00299 MAP2K6 - Dual specificity mitogen-activated protein kinase kinase 6 - Bos taurus (Bovine) - MAP2K6 gene Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases (By similarity). Taurus_UMD|evm.model.AC_000176.1.1213 Q8WWZ7 ABCA5_HUMAN 87.252 0.998081 0.951888 ABCA5 - Cholesterol transporter ABCA5 - Homo sapiens (Human) - ABCA5 gene Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity). Taurus_UMD|evm.model.AC_000176.1.1214 Q8WWZ4 ABCAA_HUMAN 69.171 0.963659 1.03435 ABCA10 - ATP-binding cassette sub-family A member 10 - Homo sapiens (Human) - ABCA10 gene Probable transporter which may play a role in macrophage lipid transport and homeostasis. Taurus_UMD|evm.model.AC_000176.1.1215 Q8IUA7 ABCA9_HUMAN 77.292 0.499385 2.00123 ABCA9 - ATP-binding cassette sub-family A member 9 - Homo sapiens (Human) - ABCA9 gene Transporter that may play a role in monocyte differentiation and lipid transport and homeostasis. Taurus_UMD|evm.model.AC_000176.1.1217 Q96MK3 FA20A_HUMAN 88.692 0.935551 0.889094 FAM20A - Pseudokinase FAM20A precursor - Homo sapiens (Human) - FAM20A gene Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. Taurus_UMD|evm.model.AC_000176.1.1218 P00514 KAP0_BOVIN 100.000 0.994751 1.00263 PRKAR1A - cAMP-dependent protein kinase type I-alpha regulatory subunit - Bos taurus (Bovine) - PRKAR1A gene Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Taurus_UMD|evm.model.AC_000176.1.1220 Q5MNZ9 WIPI1_HUMAN 90.215 0.537967 1.74215 WIPI1 - WD repeat domain phosphoinositide-interacting protein 1 - Homo sapiens (Human) - WIPI1 gene Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Plays an important role in starvation- and calcium-mediated autophagy, as well as in mitophagy (PubMed:28561066). Functions downstream of the ULK1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes (PubMed:28561066, PubMed:33499712). There, it assists WIPI2 in the recruitment of ATG12-ATG5-ATG16L1, a complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:28561066). Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. Taurus_UMD|evm.model.AC_000176.1.1221 Q96EG1 ARSG_HUMAN 78.049 0.948598 0.407619 ARSG - Arylsulfatase G precursor - Homo sapiens (Human) - ARSG gene Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. Taurus_UMD|evm.model.AC_000176.1.1222 B1AT66 MOT7_MOUSE 78.131 0.801829 1.08072 Slc16a6 - Monocarboxylate transporter 7 - Mus musculus (Mouse) - Slc16a6 gene Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). Taurus_UMD|evm.model.AC_000176.1.1223 Q86W34 AMZ2_HUMAN 80.556 0.99446 1.00278 AMZ2 - Archaemetzincin-2 - Homo sapiens (Human) - AMZ2 gene Probable zinc metalloprotease. Taurus_UMD|evm.model.AC_000176.1.1224 Q14344 GNA13_HUMAN 90.071 0.992481 0.70557 GNA13 - Guanine nucleotide-binding protein subunit alpha-13 - Homo sapiens (Human) - GNA13 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). Taurus_UMD|evm.model.AC_000176.1.1225 O46469 RGS9_BOVIN 94.480 0.696124 1.33264 RGS9 - Regulator of G-protein signaling 9 - Bos taurus (Bovine) - RGS9 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction. Taurus_UMD|evm.model.AC_000176.1.1228 Q9Y2T1 AXIN2_HUMAN 81.087 0.997613 0.994069 AXIN2 - Axin-2 - Homo sapiens (Human) - AXIN2 gene Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. Taurus_UMD|evm.model.AC_000176.1.1230 P17690 APOH_BOVIN 99.420 0.99422 1.0029 APOH - Beta-2-glycoprotein 1 precursor - Bos taurus (Bovine) - APOH gene Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. Taurus_UMD|evm.model.AC_000176.1.1231 P04409 KPCA_BOVIN 92.659 0.835536 1.01339 PRKCA - Protein kinase C alpha type - Bos taurus (Bovine) - PRKCA gene Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation. In cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Depending on the cell type, exhibits anti-apoptotic function and protects cells from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, or mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (By similarity). Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteosomal degradation (By similarity). Taurus_UMD|evm.model.AC_000176.1.1232 Q8VHW4 CCG5_MOUSE 92.000 0.992754 1.00364 Cacng5 - Voltage-dependent calcium channel gamma-5 subunit - Mus musculus (Mouse) - Cacng5 gene Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). Taurus_UMD|evm.model.AC_000176.1.1235 Q9UBN1 CCG4_HUMAN 83.871 0.386076 0.48318 CACNG4 - Voltage-dependent calcium channel gamma-4 subunit - Homo sapiens (Human) - CACNG4 gene Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:21172611). Taurus_UMD|evm.model.AC_000176.1.1236 Q8VHW9 CCG4_RAT 94.862 0.845361 0.889908 Cacng4 - Voltage-dependent calcium channel gamma-4 subunit - Rattus norvegicus (Rat) - Cacng4 gene Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:17880894, PubMed:19234459). Taurus_UMD|evm.model.AC_000176.1.1237 Q08DE1 CCG1_BOVIN 100.000 0.991071 1.00448 CACNG1 - Voltage-dependent calcium channel gamma-1 subunit - Bos taurus (Bovine) - CACNG1 gene Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. Taurus_UMD|evm.model.AC_000176.1.1238 P42694 HELZ_HUMAN 90.496 0.998308 0.608651 HELZ - Probable helicase with zinc finger domain - Homo sapiens (Human) - HELZ gene May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. Taurus_UMD|evm.model.AC_000176.1.1239 P42694 HELZ_HUMAN 93.770 0.86119 0.181771 HELZ - Probable helicase with zinc finger domain - Homo sapiens (Human) - HELZ gene May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. Taurus_UMD|evm.model.AC_000176.1.1240 P42694 HELZ_HUMAN 95.866 0.987212 0.201339 HELZ - Probable helicase with zinc finger domain - Homo sapiens (Human) - HELZ gene May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. Taurus_UMD|evm.model.AC_000176.1.1241 P26452 RSSA_BOVIN 56.140 0.329193 0.545763 RPSA - 40S ribosomal protein SA - Bos taurus (Bovine) - RPSA gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. Taurus_UMD|evm.model.AC_000177.1.1 Q8NGL1 OR5DI_HUMAN 63.077 0.959016 0.389776 OR5D18 - Olfactory receptor 5D18 - Homo sapiens (Human) - OR5D18 gene Odorant receptor. Taurus_UMD|evm.model.AC_000177.1.5 Q13606 OR5I1_HUMAN 85.169 0.995536 0.713376 OR5I1 - Olfactory receptor 5I1 - Homo sapiens (Human) - OR5I1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000177.1.7 Q8NGL4 OR5DD_HUMAN 78.873 0.693069 0.321656 OR5D13 - Olfactory receptor 5D13 - Homo sapiens (Human) - OR5D13 gene Odorant receptor. Taurus_UMD|evm.model.AC_000177.1.9 Q8NGL7 OR4P4_HUMAN 50.394 0.990291 0.330128 OR4P4 - Olfactory receptor 4P4 - Homo sapiens (Human) - OR4P4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000177.1.10 Q32L17 SPZ1_BOVIN 100.000 0.820399 1.21563 SPZ1 - Spermatogenic leucine zipper protein 1 - Bos taurus (Bovine) - SPZ1 gene Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity). Taurus_UMD|evm.model.AC_000177.1.11 Q08DA5 PANK3_BOVIN 100.000 0.994609 1.0027 PANK3 - Pantothenate kinase 3 - Bos taurus (Bovine) - PANK3 gene Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. Taurus_UMD|evm.model.AC_000177.1.12 O75094 SLIT3_HUMAN 86.145 0.939759 0.980959 SLIT3 - Slit homolog 3 protein precursor - Homo sapiens (Human) - SLIT3 gene May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors. Taurus_UMD|evm.model.AC_000177.1.13 Q08DR9 SPDLY_BOVIN 99.834 0.996689 1.00166 SPDL1 - Protein Spindly - Bos taurus (Bovine) - SPDL1 gene Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Plays a role in cell migration (By similarity). Taurus_UMD|evm.model.AC_000177.1.14 Q92608 DOCK2_HUMAN 97.561 0.984699 0.5 DOCK2 - Dedicator of cytokinesis protein 2 - Homo sapiens (Human) - DOCK2 gene Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. Taurus_UMD|evm.model.AC_000177.1.15 A6NMK8 INY2B_HUMAN 79.439 0.996071 0.951402 INSYN2B - Protein INSYN2B - Homo sapiens (Human) - INSYN2B gene Taurus_UMD|evm.model.AC_000177.1.16 Q92608 DOCK2_HUMAN 95.316 0.480864 0.556831 DOCK2 - Dedicator of cytokinesis protein 2 - Homo sapiens (Human) - DOCK2 gene Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. Taurus_UMD|evm.model.AC_000177.1.17 Q12951 FOXI1_HUMAN 81.675 0.994737 1.00529 FOXI1 - Forkhead box protein I1 - Homo sapiens (Human) - FOXI1 gene Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity). Taurus_UMD|evm.model.AC_000177.1.18 Q8BUR4 DOCK1_MOUSE 66.667 0.126984 0.270241 Dock1 - Dedicator of cytokinesis protein 1 - Mus musculus (Mouse) - Dock1 gene Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. Taurus_UMD|evm.model.AC_000177.1.19 C9J3I9 CE058_HUMAN 70.000 0.632 1.22549 C5orf58 - Putative uncharacterized protein C5orf58 - Homo sapiens (Human) - C5orf58 gene Taurus_UMD|evm.model.AC_000177.1.20 Q13094 LCP2_HUMAN 83.677 0.996248 1 LCP2 - Lymphocyte cytosolic protein 2 - Homo sapiens (Human) - LCP2 gene Involved in T-cell antigen receptor mediated signaling. Taurus_UMD|evm.model.AC_000177.1.21 Q28067 KCMB1_BOVIN 100.000 0.989583 1.00524 KCNMB1 - Calcium-activated potassium channel subunit beta-1 - Bos taurus (Bovine) - KCNMB1 gene Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate (By similarity). Taurus_UMD|evm.model.AC_000177.1.23 Q9JJ57 KCIP1_MOUSE 98.469 0.955882 0.898678 Kcnip1 - Kv channel-interacting protein 1 - Mus musculus (Mouse) - Kcnip1 gene Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND2/Kv4.2 currents (PubMed:14572458). In vitro, modulates KCND1/Kv4.1 currents (By similarity). Increases the presence of KCND2 at the cell surface. Taurus_UMD|evm.model.AC_000177.1.24 Q5EA06 GBRP_BOVIN 100.000 0.995465 1.00227 GABRP - Gamma-aminobutyric acid receptor subunit pi precursor - Bos taurus (Bovine) - GABRP gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone (By similarity). Taurus_UMD|evm.model.AC_000177.1.25 Q9H2T7 RBP17_HUMAN 94.124 0.997861 0.859375 RANBP17 - Ran-binding protein 17 - Homo sapiens (Human) - RANBP17 gene May function as a nuclear transport receptor. Taurus_UMD|evm.model.AC_000177.1.26 O43711 TLX3_HUMAN 98.625 0.855457 1.16495 TLX3 - T-cell leukemia homeobox protein 3 - Homo sapiens (Human) - TLX3 gene chromatin, nucleoplasm, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, animal organ development, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000177.1.27 Q3T160 NPM_BOVIN 98.944 0.698765 1.37755 NPM1 - Nucleophosmin - Bos taurus (Bovine) - NPM1 gene Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. Taurus_UMD|evm.model.AC_000177.1.28 P62246 RS15A_RAT 100.000 0.984733 1.00769 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Taurus_UMD|evm.model.AC_000177.1.29 O89101 FGF18_MOUSE 100.000 0.782051 0.753623 Fgf18 - Fibroblast growth factor 18 precursor - Mus musculus (Mouse) - Fgf18 gene Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation (By similarity). Taurus_UMD|evm.model.AC_000177.1.31 Q9DAL0 SIM23_MOUSE 63.971 0.948905 1.00735 Smim23 - Small integral membrane protein 23 - Mus musculus (Mouse) - Smim23 gene Taurus_UMD|evm.model.AC_000177.1.32 Q15120 PDK3_HUMAN 82.039 0.97619 0.517241 PDK3 - [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial precursor - Homo sapiens (Human) - PDK3 gene Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. Taurus_UMD|evm.model.AC_000177.1.36 E1BK52 STK10_BOVIN 100.000 0.996901 1.00207 STK10 - Serine/threonine-protein kinase 10 - Bos taurus (Bovine) - STK10 gene Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo (By similarity). Taurus_UMD|evm.model.AC_000177.1.37 A8MZ26 EFCB9_HUMAN 69.474 0.847534 1.13198 EFCAB9 - EF-hand calcium-binding domain-containing protein 9 - Homo sapiens (Human) - EFCAB9 gene pH-dependent Ca(2+) sensor required to activate the CatSper channel, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+). Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel. Taurus_UMD|evm.model.AC_000177.1.38 Q5EAE3 UBTD2_BOVIN 100.000 0.991489 1.00427 UBTD2 - Ubiquitin domain-containing protein 2 - Bos taurus (Bovine) - UBTD2 gene Taurus_UMD|evm.model.AC_000177.1.39 A1X283 SPD2B_HUMAN 85.905 0.993341 0.989023 SH3PXD2B - SH3 and PX domain-containing protein 2B - Homo sapiens (Human) - SH3PXD2B gene Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). Taurus_UMD|evm.model.AC_000177.1.41 A8MQ27 NEU1B_HUMAN 95.676 0.996403 1.0018 NEURL1B - E3 ubiquitin-protein ligase NEURL1B - Homo sapiens (Human) - NEURL1B gene E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands. Taurus_UMD|evm.model.AC_000177.1.42 P28562 DUS1_HUMAN 96.730 0.994565 1.00272 DUSP1 - Dual specificity protein phosphatase 1 - Homo sapiens (Human) - DUSP1 gene Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. Taurus_UMD|evm.model.AC_000177.1.44 Q969X5 ERGI1_HUMAN 97.241 0.993127 1.00345 ERGIC1 - Endoplasmic reticulum-Golgi intermediate compartment protein 1 - Homo sapiens (Human) - ERGIC1 gene Possible role in transport between endoplasmic reticulum and Golgi. Taurus_UMD|evm.model.AC_000177.1.45 Q9UNX3 RL26L_HUMAN 93.377 0.802139 1.28966 RPL26L1 - 60S ribosomal protein L26-like 1 - Homo sapiens (Human) - RPL26L1 gene cytosolic large ribosomal subunit, extracellular exosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, ribosomal large subunit biogenesis Taurus_UMD|evm.model.AC_000177.1.46 P81103 VA0E1_BOVIN 100.000 0.471154 1.28395 ATP6V0E1 - V-type proton ATPase subunit e 1 - Bos taurus (Bovine) - ATP6V0E1 gene Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Taurus_UMD|evm.model.AC_000177.1.47 Q8IUR6 CRERF_HUMAN 97.966 0.996875 1.00156 CREBRF - CREB3 regulatory factor - Homo sapiens (Human) - CREBRF gene Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci. Taurus_UMD|evm.model.AC_000177.1.48 Q8VHI8 SEC20_RAT 94.737 0.991266 1.00439 Bnip1 - Vesicle transport protein SEC20 - Rattus norvegicus (Rat) - Bnip1 gene As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization. Plays also a role in apoptosis. It is for instance required for endoplasmic reticulum stress-induced apoptosis. As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy. Taurus_UMD|evm.model.AC_000177.1.51 P52952 NKX25_HUMAN 94.753 0.993827 1 NKX2-5 - Homeobox protein Nkx-2.5 - Homo sapiens (Human) - NKX2-5 gene Transcription factor required for the development of the heart and the spleen (PubMed:22560297). During heart development, acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter (PubMed:22849347, PubMed:26926761). Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297). Taurus_UMD|evm.model.AC_000177.1.53 O97561 STC2_MACNE 91.391 0.993399 1.00331 STC2 - Stanniocalcin-2 precursor - Macaca nemestrina (Pig-tailed macaque) - STC2 gene Has an anti-hypocalcemic action on calcium and phosphate homeostasis. Taurus_UMD|evm.model.AC_000177.1.54 Q5SQY2 BOD1_MOUSE 97.959 0.784946 1.07514 Bod1 - Biorientation of chromosomes in cell division protein 1 - Mus musculus (Mouse) - Bod1 gene Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. Taurus_UMD|evm.model.AC_000177.1.56 Q3ZBH3 CD151_BOVIN 51.515 0.938272 0.960474 CD151 - CD151 antigen - Bos taurus (Bovine) - CD151 gene Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. Taurus_UMD|evm.model.AC_000177.1.57 Q17RY0 CPEB4_HUMAN 98.491 0.99723 0.990398 CPEB4 - Cytoplasmic polyadenylation element-binding protein 4 - Homo sapiens (Human) - CPEB4 gene Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). Taurus_UMD|evm.model.AC_000177.1.58 Q569G3 CE047_HUMAN 63.889 0.442308 0.886364 C5orf47 - Uncharacterized protein C5orf47 - Homo sapiens (Human) - C5orf47 gene Taurus_UMD|evm.model.AC_000177.1.59 Q569G3 CE047_HUMAN 70.270 0.73 0.568182 C5orf47 - Uncharacterized protein C5orf47 - Homo sapiens (Human) - C5orf47 gene Taurus_UMD|evm.model.AC_000177.1.60 Q0VCZ0 NSG2_BOVIN 61.111 0.73913 0.672515 NSG2 - Neuronal vesicle trafficking-associated protein 2 - Bos taurus (Bovine) - NSG2 gene cytoplasmic vesicle membrane, dendrite, early endosome, endosome, Golgi cis cisterna membrane, integral component of membrane, late endosome, multivesicular body membrane, trans-Golgi network membrane, clathrin light chain binding Taurus_UMD|evm.model.AC_000177.1.61 Q3ZBZ8 STIP1_BOVIN 85.163 0.94362 0.620626 STIP1 - Stress-induced-phosphoprotein 1 - Bos taurus (Bovine) - STIP1 gene Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. Taurus_UMD|evm.model.AC_000177.1.62 Q3ZBZ8 STIP1_BOVIN 93.064 0.988506 0.320442 STIP1 - Stress-induced-phosphoprotein 1 - Bos taurus (Bovine) - STIP1 gene Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. Taurus_UMD|evm.model.AC_000177.1.63 P02316 HMGN1_BOVIN 96.040 0.980198 1 HMGN1 - Non-histone chromosomal protein HMG-14 - Bos taurus (Bovine) - HMGN1 gene Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). Taurus_UMD|evm.model.AC_000177.1.64 Q0VCZ0 NSG2_BOVIN 95.283 0.860656 0.71345 NSG2 - Neuronal vesicle trafficking-associated protein 2 - Bos taurus (Bovine) - NSG2 gene cytoplasmic vesicle membrane, dendrite, early endosome, endosome, Golgi cis cisterna membrane, integral component of membrane, late endosome, multivesicular body membrane, trans-Golgi network membrane, clathrin light chain binding Taurus_UMD|evm.model.AC_000177.1.66 Q4R4U3 PRPS1_MACFA 76.812 0.731183 0.292453 PRPS1 - Ribose-phosphate pyrophosphokinase 1 - Macaca fascicularis (Crab-eating macaque) - PRPS1 gene Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Taurus_UMD|evm.model.AC_000177.1.67 O95476 CNEP1_HUMAN 89.189 0.982143 0.459016 CTDNEP1 - CTD nuclear envelope phosphatase 1 - Homo sapiens (Human) - CTDNEP1 gene Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling. Taurus_UMD|evm.model.AC_000177.1.68 Q0P5C3 MSX2_BOVIN 100.000 0.992537 1.00375 MSX2 - Homeobox protein MSX-2 - Bos taurus (Bovine) - MSX2 gene Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity). Taurus_UMD|evm.model.AC_000177.1.69 Q9Y6X4 F169A_HUMAN 78.358 0.996727 0.91194 FAM169A - Soluble lamin-associated protein of 75 kDa - Homo sapiens (Human) - FAM169A gene Taurus_UMD|evm.model.AC_000177.1.70 Q3SX11 NSA2_BOVIN 100.000 0.992337 1.00385 NSA2 - Ribosome biogenesis protein NSA2 homolog - Bos taurus (Bovine) - NSA2 gene Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). Taurus_UMD|evm.model.AC_000177.1.71 A6QNM2 RRF2M_BOVIN 100.000 0.997429 1.00129 GFM2 - Ribosome-releasing factor 2, mitochondrial - Bos taurus (Bovine) - GFM2 gene Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation. Taurus_UMD|evm.model.AC_000177.1.72 P49614 HEXB_FELCA 74.853 0.944238 1.01318 HEXB - Beta-hexosaminidase subunit beta precursor - Felis catus (Cat) - HEXB gene Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (By similarity). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity). Taurus_UMD|evm.model.AC_000177.1.73 P49614 HEXB_FELCA 66.732 0.927239 1.00942 HEXB - Beta-hexosaminidase subunit beta precursor - Felis catus (Cat) - HEXB gene Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (By similarity). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity). Taurus_UMD|evm.model.AC_000177.1.74 O14682 ENC1_HUMAN 99.660 0.99661 1.0017 ENC1 - Ectoderm-neural cortex protein 1 - Homo sapiens (Human) - ENC1 gene Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism. Taurus_UMD|evm.model.AC_000177.1.75 Q8N1W1 ARG28_HUMAN 82.074 0.998816 0.990616 ARHGEF28 - Rho guanine nucleotide exchange factor 28 - Homo sapiens (Human) - ARHGEF28 gene Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). Taurus_UMD|evm.model.AC_000177.1.76 P84089 ERH_MOUSE 95.652 0.103211 4.19231 Erh - Enhancer of rudimentary homolog - Mus musculus (Mouse) - Erh gene May have a role in the cell cycle. Taurus_UMD|evm.model.AC_000177.1.77 A7MB12 UTP15_BOVIN 100.000 0.996154 1.00193 UTP15 - U3 small nucleolar RNA-associated protein 15 homolog - Bos taurus (Bovine) - UTP15 gene Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Taurus_UMD|evm.model.AC_000177.1.79 Q2KI79 ANRA2_BOVIN 100.000 0.993631 1.00319 ANKRA2 - Ankyrin repeat family A protein 2 - Bos taurus (Bovine) - ANKRA2 gene May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (By similarity). May also regulate LRP2/megalin (By similarity). Taurus_UMD|evm.model.AC_000177.1.80 Q95339 ATPK_PIG 77.273 0.9 1.02273 ATP5MF - ATP synthase subunit f, mitochondrial - Sus scrofa (Pig) - ATP5MF gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Taurus_UMD|evm.model.AC_000177.1.81 P20290 BTF3_HUMAN 97.087 0.990338 1.00485 BTF3 - Transcription factor BTF3 - Homo sapiens (Human) - BTF3 gene When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. Taurus_UMD|evm.model.AC_000177.1.82 P0DP31 CALM3_RAT 98.658 0.986667 1.00671 Calm3 - Calmodulin-3 - Rattus norvegicus (Rat) - Calm3 gene Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Taurus_UMD|evm.model.AC_000177.1.85 Q8WUU8 TM174_HUMAN 81.780 0.991561 0.975309 TMEM174 - Transmembrane protein 174 - Homo sapiens (Human) - TMEM174 gene Taurus_UMD|evm.model.AC_000177.1.86 Q58DS4 TM171_BOVIN 100.000 0.853018 1.16871 TMEM171 - Transmembrane protein 171 - Bos taurus (Bovine) - TMEM171 gene Taurus_UMD|evm.model.AC_000177.1.87 Q0JRZ9 FCHO2_HUMAN 93.820 0.997531 1 FCHO2 - F-BAR domain only protein 2 - Homo sapiens (Human) - FCHO2 gene Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. Taurus_UMD|evm.model.AC_000177.1.88 Q3SYU7 TNPO1_BOVIN 100.000 0.360262 1.02004 TNPO1 - Transportin-1 - Bos taurus (Bovine) - TNPO1 gene Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. Mediates nuclear import of ADAR/ADAR1 in a RanGTP-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000177.1.89 Q8WNR4 H2BV_BOVIN 100.000 0.98374 1.0082 SUBH2BV - Histone H2B subacrosomal variant - Bos taurus (Bovine) - SUBH2BV gene May act as an acrosome-nuclear docking protein in sperm. Taurus_UMD|evm.model.AC_000177.1.90 Q8N895 ZN366_HUMAN 87.534 0.997308 0.998656 ZNF366 - Zinc finger protein 366 - Homo sapiens (Human) - ZNF366 gene Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases. Taurus_UMD|evm.model.AC_000177.1.91 Q3SZ55 PTCD2_BOVIN 100.000 0.994805 1.0026 PTCD2 - Pentatricopeptide repeat-containing protein 2, mitochondrial - Bos taurus (Bovine) - PTCD2 gene Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function. Taurus_UMD|evm.model.AC_000177.1.92 Q6WV90 H4_MYTGA 99.029 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000177.1.93 Q32PI8 RT27_BOVIN 99.726 0.983784 0.891566 MRPS27 - 28S ribosomal protein S27, mitochondrial precursor - Bos taurus (Bovine) - MRPS27 gene RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Overexpressed in hepatocellular carcinoma tissues compared with adjacent non-tumoral liver tissues. Taurus_UMD|evm.model.AC_000177.1.94 P46821 MAP1B_HUMAN 89.125 0.701299 0.998379 MAP1B - Microtubule-associated protein 1B - Homo sapiens (Human) - MAP1B gene Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. Taurus_UMD|evm.model.AC_000177.1.96 Q68RJ9 CART_BOVIN 100.000 0.982906 1.00862 CARTPT - Cocaine- and amphetamine-regulated transcript protein precursor - Bos taurus (Bovine) - CARTPT gene Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. Taurus_UMD|evm.model.AC_000177.1.97 Q3ULD5 MCCB_MOUSE 91.297 0.996454 1.00178 Mccc2 - Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial precursor - Mus musculus (Mouse) - Mccc2 gene Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. Taurus_UMD|evm.model.AC_000177.1.98 A6H8Y1 BDP1_HUMAN 62.242 0.474711 1.05488 BDP1 - Transcription factor TFIIIB component B'' homolog - Homo sapiens (Human) - BDP1 gene General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. Taurus_UMD|evm.model.AC_000177.1.99 Q32P76 SERF1_BOVIN 98.361 0.266667 3.62903 SERF1 - Small EDRK-rich factor 1 - Bos taurus (Bovine) - SERF1 gene Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity). Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates (By similarity). Taurus_UMD|evm.model.AC_000177.1.100 O18870 SMN_BOVIN 100.000 0.986207 1.01045 SMN1 - Survival motor neuron protein - Bos taurus (Bovine) - SMN1 gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). Taurus_UMD|evm.model.AC_000177.1.101 Q13075 BIRC1_HUMAN 71.571 0.996446 1.00285 NAIP - Baculoviral IAP repeat-containing protein 1 - Homo sapiens (Human) - NAIP gene Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy. Taurus_UMD|evm.model.AC_000177.1.102 Q2TBV5 TF2H2_BOVIN 100.000 0.971649 0.982278 GTF2H2 - General transcription factor IIH subunit 2 - Bos taurus (Bovine) - GTF2H2 gene Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. Taurus_UMD|evm.model.AC_000177.1.103 Q16625 OCLN_HUMAN 90.249 0.996176 1.00192 OCLN - Occludin - Homo sapiens (Human) - OCLN gene May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. Taurus_UMD|evm.model.AC_000177.1.104 Q8N4S9 MALD2_HUMAN 88.689 0.992857 1.00358 MARVELD2 - MARVEL domain-containing protein 2 - Homo sapiens (Human) - MARVELD2 gene Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). Taurus_UMD|evm.model.AC_000177.1.105 O75943 RAD17_HUMAN 84.919 0.958824 0.998532 RAD17 - Cell cycle checkpoint protein RAD17 - Homo sapiens (Human) - RAD17 gene Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination. Taurus_UMD|evm.model.AC_000177.1.106 A5PJA1 KAD6_BOVIN 97.619 0.616236 1.57558 AK6 - Adenylate kinase isoenzyme 6 - Bos taurus (Bovine) - AK6 gene Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation. Taurus_UMD|evm.model.AC_000177.1.108 Q86Z20 CC125_HUMAN 76.608 0.994163 1.00587 CCDC125 - Coiled-coil domain-containing protein 125 - Homo sapiens (Human) - CCDC125 gene May be involved in the regulation of cell migration. Taurus_UMD|evm.model.AC_000177.1.109 P51952 CDK7_RAT 96.960 0.945245 1.05471 Cdk7 - Cyclin-dependent kinase 7 - Rattus norvegicus (Rat) - Cdk7 gene Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition (By similarity). Taurus_UMD|evm.model.AC_000177.1.110 P82908 RT36_BOVIN 100.000 0.980769 1.00971 MRPS36 - 28S ribosomal protein S36, mitochondrial - Bos taurus (Bovine) - MRPS36 gene May be necessary to recruit DLD/E3 to the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDC) core composed of OGDH/E1-DLST/E2, hence stabilizes the complex. Taurus_UMD|evm.model.AC_000177.1.111 Q3T0L1 CENPH_BOVIN 100.000 0.991837 1.0041 CENPH - Centromere protein H - Bos taurus (Bovine) - CENPH gene Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Taurus_UMD|evm.model.AC_000177.1.112 Q1LZG6 CCNB1_BOVIN 100.000 0.995327 1.00234 CCNB1 - G2/mitotic-specific cyclin-B1 - Bos taurus (Bovine) - CCNB1 gene Essential for the control of the cell cycle at the G2/M (mitosis) transition. Taurus_UMD|evm.model.AC_000177.1.113 Q8TAD4 ZNT5_HUMAN 93.888 0.997403 1.00654 SLC30A5 - Zinc transporter 5 - Homo sapiens (Human) - SLC30A5 gene Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP. Taurus_UMD|evm.model.AC_000177.1.115 P23727 P85A_BOVIN 100.000 0.997241 1.00138 PIK3R1 - Phosphatidylinositol 3-kinase regulatory subunit alpha - Bos taurus (Bovine) - PIK3R1 gene Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). Taurus_UMD|evm.model.AC_000177.1.119 P63170 DYL1_RAT 100.000 0.977778 1.01124 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Taurus_UMD|evm.model.AC_000177.1.122 Q99467 CD180_HUMAN 78.064 0.996979 1.00151 CD180 - CD180 antigen precursor - Homo sapiens (Human) - CD180 gene May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity). Taurus_UMD|evm.model.AC_000177.1.123 O15021 MAST4_HUMAN 84.944 0.630868 1.18567 MAST4 - Microtubule-associated serine/threonine-protein kinase 4 - Homo sapiens (Human) - MAST4 gene protein serine/threonine kinase activity, cytoskeleton organization, intracellular signal transduction, peptidyl-serine phosphorylation Taurus_UMD|evm.model.AC_000177.1.124 O15021 MAST4_HUMAN 77.869 0.581633 0.0747236 MAST4 - Microtubule-associated serine/threonine-protein kinase 4 - Homo sapiens (Human) - MAST4 gene protein serine/threonine kinase activity, cytoskeleton organization, intracellular signal transduction, peptidyl-serine phosphorylation Taurus_UMD|evm.model.AC_000177.1.127 Q8WXA9 SREK1_HUMAN 86.458 0.934853 0.604331 SREK1 - Splicing regulatory glutamine/lysine-rich protein 1 - Homo sapiens (Human) - SREK1 gene Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). Taurus_UMD|evm.model.AC_000177.1.128 Q8WXA9 SREK1_HUMAN 99.541 0.990868 0.431102 SREK1 - Splicing regulatory glutamine/lysine-rich protein 1 - Homo sapiens (Human) - SREK1 gene Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). Taurus_UMD|evm.model.AC_000177.1.129 Q96RT1 ERBIN_HUMAN 89.391 0.985811 1.04816 ERBIN - Erbin - Homo sapiens (Human) - ERBIN gene Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728). Taurus_UMD|evm.model.AC_000177.1.130 A2VDQ5 NEUL_BOVIN 99.625 0.996255 0.758523 NLN - Neurolysin, mitochondrial precursor - Bos taurus (Bovine) - NLN gene Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Taurus_UMD|evm.model.AC_000177.1.131 A2VDQ5 NEUL_BOVIN 99.167 0.82069 0.205966 NLN - Neurolysin, mitochondrial precursor - Bos taurus (Bovine) - NLN gene Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Taurus_UMD|evm.model.AC_000177.1.132 Q96EQ0 SGTB_HUMAN 85.855 0.992593 0.888158 SGTB - Small glutamine-rich tetratricopeptide repeat-containing protein beta - Homo sapiens (Human) - SGTB gene Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. Taurus_UMD|evm.model.AC_000177.1.133 A7MB76 TPC13_BOVIN 99.761 0.995227 1.0048 TRAPPC13 - Trafficking protein particle complex subunit 13 - Bos taurus (Bovine) - TRAPPC13 gene TRAPPIII protein complex Taurus_UMD|evm.model.AC_000177.1.134 Q8BGX0 TRI23_MOUSE 98.084 0.996522 1.00174 Trim23 - E3 ubiquitin-protein ligase TRIM23 - Mus musculus (Mouse) - Trim23 gene Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes. Taurus_UMD|evm.model.AC_000177.1.135 Q29RZ2 PPWD1_BOVIN 100.000 0.996899 1.00155 PPWD1 - Peptidylprolyl isomerase domain and WD repeat-containing protein 1 - Bos taurus (Bovine) - PPWD1 gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be involved in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000177.1.136 Q5XGL1 CENPK_XENLA 69.388 0.231884 0.755474 cenpk - Centromere protein K - Xenopus laevis (African clawed frog) - cenpk gene Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Taurus_UMD|evm.model.AC_000177.1.137 Q9UKP5 ATS6_HUMAN 98.117 0.995064 0.906893 ADAMTS6 - A disintegrin and metalloproteinase with thrombospondin motifs 6 precursor - Homo sapiens (Human) - ADAMTS6 gene extracellular matrix, metalloendopeptidase activity, metallopeptidase activity, extracellular matrix organization Taurus_UMD|evm.model.AC_000177.1.138 Q17QX9 CWC27_BOVIN 99.577 0.995781 1.00211 CWC27 - Spliceosome-associated protein CWC27 homolog - Bos taurus (Bovine) - CWC27 gene As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. Taurus_UMD|evm.model.AC_000177.1.139 Q8N9Q2 SR1IP_HUMAN 95.312 0.396226 1.02581 SREK1IP1 - Protein SREK1IP1 - Homo sapiens (Human) - SREK1IP1 gene Possible splicing regulator involved in the control of cellular survival. Taurus_UMD|evm.model.AC_000177.1.140 A6QQ93 SHL2B_BOVIN 100.000 0.987654 1.00621 SHISAL2B - Protein shisa-like-2B - Bos taurus (Bovine) - SHISAL2B gene Taurus_UMD|evm.model.AC_000177.1.141 Q08DH5 R7BP_BOVIN 100.000 0.992248 1.00389 RGS7BP - Regulator of G-protein signaling 7-binding protein - Bos taurus (Bovine) - RGS7BP gene Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation. Taurus_UMD|evm.model.AC_000177.1.142 Q86T96 RN180_HUMAN 85.642 0.996558 0.981419 RNF180 - E3 ubiquitin-protein ligase RNF180 - Homo sapiens (Human) - RNF180 gene E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. Taurus_UMD|evm.model.AC_000177.1.143 Q0EAB6 5HT1A_HORSE 92.417 0.995272 1.00237 HTR1A - 5-hydroxytryptamine receptor 1A - Equus caballus (Horse) - HTR1A gene G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli (By similarity). Taurus_UMD|evm.model.AC_000177.1.145 Q9UI26 IPO11_HUMAN 94.051 0.997886 0.970256 IPO11 - Importin-11 - Homo sapiens (Human) - IPO11 gene Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity). Taurus_UMD|evm.model.AC_000177.1.146 Q2KHT8 DIM1_BOVIN 100.000 0.993631 1.00319 DIMT1 - Probable dimethyladenosine transferase - Bos taurus (Bovine) - DIMT1 gene Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Taurus_UMD|evm.model.AC_000177.1.147 O00139 KIF2A_HUMAN 99.150 0.997171 1.00142 KIF2A - Kinesin-like protein KIF2A - Homo sapiens (Human) - KIF2A gene Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. Taurus_UMD|evm.model.AC_000177.1.148 Q99933 BAG1_HUMAN 83.051 0.987395 0.689855 BAG1 - BAG family molecular chaperone regulator 1 - Homo sapiens (Human) - BAG1 gene Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631). Taurus_UMD|evm.model.AC_000177.1.150 Q9HCJ5 ZSWM6_HUMAN 98.889 0.990982 0.821399 ZSWIM6 - Zinc finger SWIM domain-containing protein 6 - Homo sapiens (Human) - ZSWIM6 gene involved in nervous system development, important for striatal morphology and motor regulation. Taurus_UMD|evm.model.AC_000177.1.151 Q32P65 NDUF2_BOVIN 99.405 0.988166 1.00595 NDUFAF2 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 precursor - Bos taurus (Bovine) - NDUFAF2 gene Acts as a molecular chaperone for mitochondrial complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000177.1.152 Q5BIM8 ERCC8_BOVIN 100.000 0.994975 1.00252 ERCC8 - DNA excision repair protein ERCC-8 - Bos taurus (Bovine) - ERCC8 gene Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair (By similarity). The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair (By similarity). It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (By similarity). Plays a role in DNA single-strand and double-strand breaks (DSSBs) repair; involved in repair of DSSBs by non-homologous end joining (NHEJ) (By similarity). Taurus_UMD|evm.model.AC_000177.1.153 A0JNC4 ELOV7_BOVIN 100.000 0.952206 0.967972 ELOVL7 - Elongation of very long chain fatty acids protein 7 - Bos taurus (Bovine) - ELOVL7 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Taurus_UMD|evm.model.AC_000177.1.154 Q4R623 DEP1B_MACFA 98.077 0.233032 0.835539 DEPDC1B - DEP domain-containing protein 1B - Macaca fascicularis (Crab-eating macaque) - DEPDC1B gene Taurus_UMD|evm.model.AC_000177.1.155 P02301 H3C_MOUSE 57.937 0.978495 0.683824 H3-5 - Histone H3.3C - Mus musculus (Mouse) - H3-5 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000177.1.156 Q01063 PDE4D_MOUSE 86.076 0.906977 0.115127 Pde4d - cAMP-specific 3',5'-cyclic phosphodiesterase 4D - Mus musculus (Mouse) - Pde4d gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Taurus_UMD|evm.model.AC_000177.1.157 Q08499 PDE4D_HUMAN 93.966 0.743421 0.187886 PDE4D - cAMP-specific 3',5'-cyclic phosphodiesterase 4D - Homo sapiens (Human) - PDE4D gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Taurus_UMD|evm.model.AC_000177.1.161 Q01063 PDE4D_MOUSE 97.147 0.951359 0.935743 Pde4d - cAMP-specific 3',5'-cyclic phosphodiesterase 4D - Mus musculus (Mouse) - Pde4d gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Taurus_UMD|evm.model.AC_000177.1.162 P10949 RAB3C_BOVIN 100.000 0.990909 0.969163 RAB3C - Ras-related protein Rab-3C - Bos taurus (Bovine) - RAB3C gene Protein transport. Probably involved in vesicular traffic (By similarity). Taurus_UMD|evm.model.AC_000177.1.163 Q8N292 GAPT_HUMAN 69.620 0.987421 1.01274 GAPT - Protein GAPT - Homo sapiens (Human) - GAPT gene Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity). Taurus_UMD|evm.model.AC_000177.1.164 Q9NYY3 PLK2_HUMAN 97.956 0.997085 1.00146 PLK2 - Serine/threonine-protein kinase PLK2 - Homo sapiens (Human) - PLK2 gene Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. Taurus_UMD|evm.model.AC_000177.1.165 Q8BFZ3 ACTBL_MOUSE 97.340 0.994695 1.00266 Actbl2 - Beta-actin-like protein 2 - Mus musculus (Mouse) - Actbl2 gene Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Taurus_UMD|evm.model.AC_000177.1.166 P13668 STMN1_RAT 87.919 0.985915 0.95302 Stmn1 - Stathmin - Rattus norvegicus (Rat) - Stmn1 gene Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules (By similarity). Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). Taurus_UMD|evm.model.AC_000177.1.167 Q0P5K1 GPBP1_BOVIN 95.943 0.995951 1.0444 GPBP1 - Vasculin - Bos taurus (Bovine) - GPBP1 gene Functions as a GC-rich promoter-specific transactivating transcription factor. Taurus_UMD|evm.model.AC_000177.1.168 P62246 RS15A_RAT 91.538 0.984733 1.00769 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Taurus_UMD|evm.model.AC_000177.1.169 Q4R3R9 MIER3_MACFA 98.000 0.99637 1.00182 MIER3 - Mesoderm induction early response protein 3 - Macaca fascicularis (Crab-eating macaque) - MIER3 gene Transcriptional repressor. Taurus_UMD|evm.model.AC_000177.1.170 Q8NE22 SETD9_HUMAN 91.973 0.993333 1.00334 SETD9 - SET domain-containing protein 9 - Homo sapiens (Human) - SETD9 gene nucleoplasm, regulation of signal transduction by p53 class mediator Taurus_UMD|evm.model.AC_000177.1.171 Q13233 M3K1_HUMAN 93.258 0.998674 0.997354 MAP3K1 - Mitogen-activated protein kinase kinase kinase 1 - Homo sapiens (Human) - MAP3K1 gene Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). Taurus_UMD|evm.model.AC_000177.1.173 Q3KP44 ANR55_HUMAN 89.638 0.996711 0.990228 ANKRD55 - Ankyrin repeat domain-containing protein 55 - Homo sapiens (Human) - ANKRD55 gene Taurus_UMD|evm.model.AC_000177.1.174 P40189 IL6RB_HUMAN 87.378 0.997824 1.00109 IL6ST - Interleukin-6 receptor subunit beta precursor - Homo sapiens (Human) - IL6ST gene Signal-transducing molecule (PubMed:2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activate the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:2261637, PubMed:19915009, PubMed:23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). Taurus_UMD|evm.model.AC_000177.1.175 Q5W5U4 DDX4_BOVIN 99.858 0.497516 1.93278 DDX4 - Probable ATP-dependent RNA helicase DDX4 - Bos taurus (Bovine) - DDX4 gene ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs. Taurus_UMD|evm.model.AC_000177.1.176 Q8NBW4 S38A9_HUMAN 91.128 0.972973 0.989305 SLC38A9 - Sodium-coupled neutral amino acid transporter 9 - Homo sapiens (Human) - SLC38A9 gene Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:25561175, PubMed:25567906, PubMed:29053970). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids (PubMed:25561175, PubMed:25567906). Acts as an arginine sensor (PubMed:25567906, PubMed:29053970). Following activation by arginine binding, mediates transport of leucine, tyrosine and phenylalanine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation (PubMed:29053970). Taurus_UMD|evm.model.AC_000177.1.177 P60588 PLPP1_PIG 97.895 0.993007 1.00351 PLPP1 - Phospholipid phosphatase 1 - Sus scrofa (Pig) - PLPP1 gene Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (Ref.1, PubMed:8702556, PubMed:1334090). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (By similarity). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (By similarity). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (By similarity). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity). Taurus_UMD|evm.model.AC_000177.1.178 P42285 MTREX_HUMAN 99.065 0.124413 0.817658 MTREX - Exosome RNA helicase MTR4 - Homo sapiens (Human) - MTREX gene Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension (PubMed:27871484, PubMed:29844170, PubMed:29906447). Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT) (PubMed:27871484, PubMed:29844170, PubMed:21855801). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484, PubMed:29844170). PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters (PubMed:27871484). Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693). May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand (PubMed:29844170). Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex (PubMed:29906447). Plays a role in DNA damage response (PubMed:29902117). Taurus_UMD|evm.model.AC_000177.1.179 Q7Z478 DHX29_HUMAN 94.010 0.997805 0.998539 DHX29 - ATP-dependent RNA helicase DHX29 - Homo sapiens (Human) - DHX29 gene ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity. Taurus_UMD|evm.model.AC_000177.1.180 P22674 CCNO_HUMAN 86.969 0.821596 1.21714 CCNO - Cyclin-O - Homo sapiens (Human) - CCNO gene Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking. Taurus_UMD|evm.model.AC_000177.1.181 G3N1S4 MCIN_BOVIN 100.000 0.994667 1.00267 MCIDAS - Multicilin - Bos taurus (Bovine) - MCIDAS gene Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1. Taurus_UMD|evm.model.AC_000177.1.182 Q2NL01 GPX8_BOVIN 100.000 0.990476 1.00478 GPX8 - Probable glutathione peroxidase 8 - Bos taurus (Bovine) - GPX8 gene peroxidase activity Taurus_UMD|evm.model.AC_000177.1.183 Q86Y33 CD20B_HUMAN 76.904 0.923963 0.836224 CDC20B - Cell division cycle protein 20 homolog B - Homo sapiens (Human) - CDC20B gene anaphase-promoting complex, anaphase-promoting complex binding, ubiquitin ligase activator activity, anaphase-promoting complex-dependent catabolic process, positive regulation of anaphase-promoting complex-dependent catabolic process Taurus_UMD|evm.model.AC_000177.1.184 P12544 GRAA_HUMAN 72.393 0.97546 0.622137 GZMA - Granzyme A precursor - Homo sapiens (Human) - GZMA gene Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3257574, PubMed:3262682, PubMed:3263427, PubMed:32299851, PubMed:12819770). It cleaves after Lys or Arg (PubMed:32299851, PubMed:12819770). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death (PubMed:32299851). Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity (PubMed:12524539). Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (PubMed:11555662, PubMed:12628186, PubMed:16818237). Taurus_UMD|evm.model.AC_000177.1.185 Q7YRZ7 GRAA_BOVIN 99.574 0.860294 1.05426 GZMA - Granzyme A precursor - Bos taurus (Bovine) - GZMA gene Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. Taurus_UMD|evm.model.AC_000177.1.186 P49863 GRAK_HUMAN 72.917 0.991701 0.912879 GZMK - Granzyme K precursor - Homo sapiens (Human) - GZMK gene serine-type peptidase activity Taurus_UMD|evm.model.AC_000177.1.187 Q9NQ30 ESM1_HUMAN 80.000 0.989189 1.00543 ESM1 - Endothelial cell-specific molecule 1 precursor - Homo sapiens (Human) - ESM1 gene Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions. Taurus_UMD|evm.model.AC_000177.1.188 Q8VHY0 CSPG4_MOUSE 33.608 0.892872 1.03094 Cspg4 - Chondroitin sulfate proteoglycan 4 precursor - Mus musculus (Mouse) - Cspg4 gene Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. Taurus_UMD|evm.model.AC_000177.1.190 P14622 COX8A_BOVIN 98.551 0.971429 1.01449 COX8A - Cytochrome c oxidase subunit 8A, mitochondrial precursor - Bos taurus (Bovine) - COX8A gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000177.1.191 Q32LC7 G3BP1_BOVIN 95.683 0.985714 0.301075 G3BP1 - Ras GTPase-activating protein-binding protein 1 - Bos taurus (Bovine) - G3BP1 gene ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. Taurus_UMD|evm.model.AC_000177.1.192 Q96RF0 SNX18_HUMAN 96.709 0.99635 0.872611 SNX18 - Sorting nexin-18 - Homo sapiens (Human) - SNX18 gene Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. Taurus_UMD|evm.model.AC_000177.1.193 Q2KHU9 HSPB3_BOVIN 100.000 0.986667 1.00671 HSPB3 - Heat shock protein beta-3 - Bos taurus (Bovine) - HSPB3 gene Inhibitor of actin polymerization. Taurus_UMD|evm.model.AC_000177.1.194 Q5EA19 ARL15_BOVIN 100.000 0.990148 1.00495 ARL15 - ADP-ribosylation factor-like protein 15 - Bos taurus (Bovine) - ARL15 gene Taurus_UMD|evm.model.AC_000177.1.195 Q02375 NDUS4_BOVIN 100.000 0.988636 1.00571 NDUFS4 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor - Bos taurus (Bovine) - NDUFS4 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000177.1.196 P50291 FST_BOVIN 100.000 0.994203 1.00291 FST - Follistatin precursor - Bos taurus (Bovine) - FST gene Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). Taurus_UMD|evm.model.AC_000177.1.197 P24049 RL17_RAT 81.522 0.988024 0.907609 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000177.1.198 A4FUY7 MOC2B_BOVIN 98.148 0.657143 1.2963 MOCS2 - Molybdopterin synthase catalytic subunit - Bos taurus (Bovine) - MOCS2 gene Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. Taurus_UMD|evm.model.AC_000177.1.199 P53710 ITA2_BOVIN 99.829 0.990678 1.00855 ITGA2 - Integrin alpha-2 precursor - Bos taurus (Bovine) - ITGA2 gene Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Taurus_UMD|evm.model.AC_000177.1.200 P56199 ITA1_HUMAN 91.017 0.998305 1.00085 ITGA1 - Integrin alpha-1 precursor - Homo sapiens (Human) - ITGA1 gene Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Taurus_UMD|evm.model.AC_000177.1.201 P14381 YTX2_XENLA 33.654 0.559783 0.140673 Transposon TX1 uncharacterized 149 kDa protein - Xenopus laevis (African clawed frog) Taurus_UMD|evm.model.AC_000177.1.202 P08548 LIN1_NYCCO 57.233 0.993651 0.25 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Taurus_UMD|evm.model.AC_000177.1.203 P61374 ISL1_RAT 100.000 0.820823 1.18338 Isl1 - Insulin gene enhancer protein ISL-1 - Rattus norvegicus (Rat) - Isl1 gene DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (By similarity). Binds to insulin gene enhancer sequences (PubMed:1691825). Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity). Taurus_UMD|evm.model.AC_000177.1.207 Q8N3A8 PARP8_HUMAN 97.424 0.954139 1.04684 PARP8 - Protein mono-ADP-ribosyltransferase PARP8 - Homo sapiens (Human) - PARP8 gene Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Taurus_UMD|evm.model.AC_000177.1.208 Q6PCB8 EMB_HUMAN 71.821 0.751295 1.18043 EMB - Embigin precursor - Homo sapiens (Human) - EMB gene Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity). Taurus_UMD|evm.model.AC_000177.1.210 Q3SZP8 TAD2A_BOVIN 82.031 0.933333 0.30474 TADA2A - Transcriptional adapter 2-alpha - Bos taurus (Bovine) - TADA2A gene Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. Taurus_UMD|evm.model.AC_000177.1.211 O88704 HCN1_MOUSE 97.218 0.817768 0.964835 Hcn1 - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 - Mus musculus (Mouse) - Hcn1 gene Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. Taurus_UMD|evm.model.AC_000177.1.212 Q10126 YSM6_CAEEL 24.684 0.552529 0.921147 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000177.1.213 P82924 RT30_BOVIN 100.000 0.995413 1.0023 MRPS30 - 28S ribosomal protein S30, mitochondrial - Bos taurus (Bovine) - MRPS30 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Taurus_UMD|evm.model.AC_000177.1.214 Q3SZB5 CC115_BOVIN 96.970 0.984962 0.738889 CCDC115 - Coiled-coil domain-containing protein 115 - Bos taurus (Bovine) - CCDC115 gene Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity). Taurus_UMD|evm.model.AC_000177.1.215 P70492 FGF10_RAT 93.913 0.965517 0.539535 Fgf10 - Fibroblast growth factor 10 precursor - Rattus norvegicus (Rat) - Fgf10 gene Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Taurus_UMD|evm.model.AC_000177.1.216 O15520 FGF10_HUMAN 75.676 0.936306 0.754808 FGF10 - Fibroblast growth factor 10 precursor - Homo sapiens (Human) - FGF10 gene Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Taurus_UMD|evm.model.AC_000177.1.217 Q5R893 H2B1_PONAB 93.651 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000177.1.218 P11024 NNTM_BOVIN 100.000 0.99816 1.00092 NNT - NAD(P) transhydrogenase, mitochondrial precursor - Bos taurus (Bovine) - NNT gene The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (By similarity). Taurus_UMD|evm.model.AC_000177.1.219 Q8VE62 PAIP1_MOUSE 96.429 0.807851 1.21 Paip1 - Polyadenylate-binding protein-interacting protein 1 - Mus musculus (Mouse) - Paip1 gene Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). Taurus_UMD|evm.model.AC_000177.1.220 A4FUB0 CE034_BOVIN 100.000 0.99687 1.00157 Uncharacterized protein C5orf34 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000177.1.221 Q17QJ2 TM267_BOVIN 100.000 0.990741 1.00465 TMEM267 - Transmembrane protein 267 - Bos taurus (Bovine) - TMEM267 gene Taurus_UMD|evm.model.AC_000177.1.223 Q01581 HMCS1_HUMAN 95.962 0.925134 1.07885 HMGCS1 - Hydroxymethylglutaryl-CoA synthase, cytoplasmic - Homo sapiens (Human) - HMGCS1 gene Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. Taurus_UMD|evm.model.AC_000177.1.224 Q8IY84 NIM1_HUMAN 94.037 0.995423 1.00229 NIM1K - Serine/threonine-protein kinase NIM1 - Homo sapiens (Human) - NIM1K gene cytoplasm, nucleus, ATP binding, magnesium ion binding, protein serine/threonine kinase activity, cellular response to glucose starvation, intracellular signal transduction, protein phosphorylation Taurus_UMD|evm.model.AC_000177.1.225 Q5RAU9 ZN131_PONAB 95.064 0.859519 0.918506 ZNF131 - Zinc finger protein 131 - Pongo abelii (Sumatran orangutan) - ZNF131 gene May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). Taurus_UMD|evm.model.AC_000177.1.226 Q5RAU9 ZN131_PONAB 100.000 0.853147 0.242784 ZNF131 - Zinc finger protein 131 - Pongo abelii (Sumatran orangutan) - ZNF131 gene May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). Taurus_UMD|evm.model.AC_000177.1.228 A6QM04 ZWILC_BOVIN 98.770 0.488934 0.843803 ZWILCH - Protein zwilch homolog - Bos taurus (Bovine) - ZWILCH gene Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity). Taurus_UMD|evm.model.AC_000177.1.233 P79103 RS4_BOVIN 84.411 0.991453 0.889734 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000177.1.234 Q02543 RL18A_HUMAN 88.182 0.981818 0.625 RPL18A - 60S ribosomal protein L18a - Homo sapiens (Human) - RPL18A gene cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, polysomal ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, rRNA processing Taurus_UMD|evm.model.AC_000177.1.235 P49908 SEPP1_HUMAN 88.991 0.635294 0.446194 SELENOP - Selenoprotein P precursor - Homo sapiens (Human) - SELENOP gene Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis. Taurus_UMD|evm.model.AC_000177.1.237 Q32LM7 CC152_BOVIN 90.875 0.992424 1.1 CCDC152 - Coiled-coil domain-containing protein 152 - Bos taurus (Bovine) - CCDC152 gene Taurus_UMD|evm.model.AC_000177.1.238 O46600 GHR_BOVIN 99.685 0.99685 1.00158 GHR - Growth hormone receptor precursor - Bos taurus (Bovine) - GHR gene Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). Taurus_UMD|evm.model.AC_000177.1.240 Q3T0J1 FBX4_BOVIN 84.491 0.995381 1.11886 FBXO4 - F-box only protein 4 - Bos taurus (Bovine) - FBXO4 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). Taurus_UMD|evm.model.AC_000177.1.241 A6NDU8 CE051_HUMAN 90.816 0.993197 1 C5orf51 - UPF0600 protein C5orf51 - Homo sapiens (Human) - C5orf51 gene cytosol, nucleoplasm Taurus_UMD|evm.model.AC_000177.1.242 Q29551 SCOT1_PIG 94.595 0.207977 0.675 OXCT1 - Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor - Sus scrofa (Pig) - OXCT1 gene Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. Taurus_UMD|evm.model.AC_000177.1.243 A6QNU9 PLCX3_BOVIN 99.688 0.993789 1.00312 PLCXD3 - PI-PLC X domain-containing protein 3 - Bos taurus (Bovine) - PLCXD3 gene Taurus_UMD|evm.model.AC_000177.1.244 Q29RU4 CO6_BOVIN 99.893 0.997856 1.00107 C6 - Complement component C6 precursor - Bos taurus (Bovine) - C6 gene Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Taurus_UMD|evm.model.AC_000177.1.245 Q7Z745 MRO2B_HUMAN 85.246 0.99874 1.00126 MROH2B - Maestro heat-like repeat-containing protein family member 2B - Homo sapiens (Human) - MROH2B gene May play a role in the process of sperm capacitation. Taurus_UMD|evm.model.AC_000177.1.246 Q29RQ1 CO7_BOVIN 99.763 0.99763 1.00119 C7 - Complement component C7 precursor - Bos taurus (Bovine) - C7 gene Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor (By similarity). Taurus_UMD|evm.model.AC_000177.1.247 Q9BX69 CARD6_HUMAN 68.517 0.998069 0.999036 CARD6 - Caspase recruitment domain-containing protein 6 - Homo sapiens (Human) - CARD6 gene May be involved in apoptosis. Taurus_UMD|evm.model.AC_000177.1.248 P61928 RL37_RAT 100.000 0.979592 1.01031 Rpl37 - 60S ribosomal protein L37 - Rattus norvegicus (Rat) - Rpl37 gene Binds to the 23S rRNA. Taurus_UMD|evm.model.AC_000177.1.249 Q13131 AAPK1_HUMAN 99.284 0.996429 1.00179 PRKAA1 - 5'-AMP-activated protein kinase catalytic subunit alpha-1 - Homo sapiens (Human) - PRKAA1 gene Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. In that process also activates WDR45 (PubMed:28561066). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1. Taurus_UMD|evm.model.AC_000177.1.250 Q6PID6 TTC33_HUMAN 93.893 0.992395 1.00382 TTC33 - Tetratricopeptide repeat protein 33 - Homo sapiens (Human) - TTC33 gene Taurus_UMD|evm.model.AC_000177.1.251 Q8MJ08 PE2R4_BOVIN 99.187 0.995943 1.00203 PTGER4 - Prostaglandin E2 receptor EP4 subtype - Bos taurus (Bovine) - PTGER4 gene Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function (By similarity). Taurus_UMD|evm.model.AC_000177.1.255 P98082 DAB2_HUMAN 86.364 0.997399 0.998701 DAB2 - Disabled homolog 2 - Homo sapiens (Human) - DAB2 gene Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. Taurus_UMD|evm.model.AC_000177.1.257 Q3MHN2 CO9_BOVIN 100.000 0.996357 1.00182 C9 - Complement component C9 precursor - Bos taurus (Bovine) - C9 gene Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. Taurus_UMD|evm.model.AC_000177.1.258 O15117 FYB1_HUMAN 79.873 0.921986 1.08046 FYB1 - FYN-binding protein 1 - Homo sapiens (Human) - FYB1 gene Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). Taurus_UMD|evm.model.AC_000177.1.259 Q6R327 RICTR_HUMAN 97.892 0.99883 1.00059 RICTOR - Rapamycin-insensitive companion of mTOR - Homo sapiens (Human) - RICTOR gene Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. Taurus_UMD|evm.model.AC_000177.1.260 Q99650 OSMR_HUMAN 67.096 0.987154 1.03371 OSMR - Oncostatin-M-specific receptor subunit beta precursor - Homo sapiens (Human) - OSMR gene Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. Taurus_UMD|evm.model.AC_000177.1.261 Q5XNR9 LIFR_CANLF 83.500 0.939863 1.06108 LIFR - Leukemia inhibitory factor receptor precursor - Canis lupus familiaris (Dog) - LIFR gene Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity). Taurus_UMD|evm.model.AC_000177.1.262 A3KN33 EGFLA_BOVIN 100.000 0.92623 0.119843 EGFLAM - Pikachurin precursor - Bos taurus (Bovine) - EGFLAM gene Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity). Taurus_UMD|evm.model.AC_000177.1.264 P39905 GDNF_HUMAN 94.313 0.990566 1.00474 GDNF - Glial cell line-derived neurotrophic factor precursor - Homo sapiens (Human) - GDNF gene Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Taurus_UMD|evm.model.AC_000177.1.265 Q32LB0 WDR70_BOVIN 99.847 0.996937 1.00153 WDR70 - WD repeat-containing protein 70 - Bos taurus (Bovine) - WDR70 gene Taurus_UMD|evm.model.AC_000177.1.266 O75694 NU155_HUMAN 96.262 0.958621 1.04242 NUP155 - Nuclear pore complex protein Nup155 - Homo sapiens (Human) - NUP155 gene Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. Taurus_UMD|evm.model.AC_000177.1.267 Q9H799 CPLN1_HUMAN 74.113 0.999381 1.01126 CPLANE1 - Ciliogenesis and planar polarity effector 1 - Homo sapiens (Human) - CPLANE1 gene Involved in ciliogenesis (PubMed:25877302). Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (By similarity). Taurus_UMD|evm.model.AC_000177.1.268 Q6KC79 NIPBL_HUMAN 97.611 0.999287 1.00036 NIPBL - Nipped-B-like protein - Homo sapiens (Human) - NIPBL gene Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). Taurus_UMD|evm.model.AC_000177.1.269 A6QLR3 ABRX2_BOVIN 98.119 0.949254 0.819071 ABRAXAS2 - BRISC complex subunit Abraxas 2 - Bos taurus (Bovine) - ABRAXAS2 gene Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (By similarity). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Required for normal induction of p53/TP53 in response to DNA damage. Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (By similarity). Taurus_UMD|evm.model.AC_000177.1.270 P46411 EAA1_BOVIN 100.000 0.996317 1.00185 SLC1A3 - Excitatory amino acid transporter 1 - Bos taurus (Bovine) - SLC1A3 gene Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7723632). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Taurus_UMD|evm.model.AC_000177.1.271 Q3SZ63 NOP56_BOVIN 84.375 0.7 0.151007 NOP56 - Nucleolar protein 56 - Bos taurus (Bovine) - NOP56 gene Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). Taurus_UMD|evm.model.AC_000177.1.272 Q95K50 NOP56_MACFA 52.137 0.247649 0.537037 NOP56 - Nucleolar protein 56 - Macaca fascicularis (Crab-eating macaque) - NOP56 gene Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Taurus_UMD|evm.model.AC_000177.1.273 Q86VV4 RNB3L_HUMAN 74.775 0.90593 1.05161 RANBP3L - Ran-binding protein 3-like - Homo sapiens (Human) - RANBP3L gene Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner. Taurus_UMD|evm.model.AC_000177.1.274 Q4G0N4 NAKD2_HUMAN 91.164 0.995699 1.05204 NADK2 - NAD kinase 2, mitochondrial precursor - Homo sapiens (Human) - NADK2 gene Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo. Taurus_UMD|evm.model.AC_000177.1.275 Q13309 SKP2_HUMAN 90.566 0.967963 1.03066 SKP2 - S-phase kinase-associated protein 2 - Homo sapiens (Human) - SKP2 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:17962192, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Taurus_UMD|evm.model.AC_000177.1.276 Q68DH5 LMBD2_HUMAN 95.827 0.997126 1.00144 LMBRD2 - G-protein coupled receptor-associated protein LMBRD2 - Homo sapiens (Human) - LMBRD2 gene Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway (PubMed:28388415). May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable). Taurus_UMD|evm.model.AC_000177.1.277 Q1LZI1 UD3A1_BOVIN 100.000 0.996183 1.00191 UGT3A1 - UDP-glucuronosyltransferase 3A1 precursor - Bos taurus (Bovine) - UGT3A1 gene UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). Taurus_UMD|evm.model.AC_000177.1.278 Q1LZI1 UD3A1_BOVIN 69.025 0.995918 0.936902 UGT3A1 - UDP-glucuronosyltransferase 3A1 precursor - Bos taurus (Bovine) - UGT3A1 gene UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). Taurus_UMD|evm.model.AC_000177.1.279 Q8WWF8 CAPSL_HUMAN 96.635 0.990431 1.00481 CAPSL - Calcyphosin-like protein - Homo sapiens (Human) - CAPSL gene Taurus_UMD|evm.model.AC_000177.1.280 A0MSX9 IL7RA_HORSE 70.153 0.905702 0.995633 IL7R - Interleukin-7 receptor subunit alpha precursor - Equus caballus (Horse) - IL7R gene Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP) (By similarity). Taurus_UMD|evm.model.AC_000177.1.281 Q2IA00 SPEF2_PIG 83.370 0.998871 0.977925 SPEF2 - Sperm flagellar protein 2 - Sus scrofa (Pig) - SPEF2 gene Required for correct axoneme development in spermatozoa (PubMed:16549801, PubMed:19889948). Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation (By similarity). Taurus_UMD|evm.model.AC_000177.1.284 Q28172 PRLR_BOVIN 99.484 0.996564 1.00172 PRLR - Prolactin receptor precursor - Bos taurus (Bovine) - PRLR gene This is a receptor for the anterior pituitary hormone prolactin. Taurus_UMD|evm.model.AC_000177.1.285 Q17QF0 AGT2_BOVIN 99.805 0.996117 1.00195 AGXT2 - Alanine--glyoxylate aminotransferase 2, mitochondrial precursor - Bos taurus (Bovine) - AGXT2 gene Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity). Taurus_UMD|evm.model.AC_000177.1.286 Q0II91 DJC21_BOVIN 95.520 0.996422 1.04878 DNAJC21 - DnaJ homolog subfamily C member 21 - Bos taurus (Bovine) - DNAJC21 gene May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. Taurus_UMD|evm.model.AC_000177.1.287 Q3SZZ0 BRX1_BOVIN 100.000 0.99435 1.00283 BRIX1 - Ribosome biogenesis protein BRX1 homolog - Bos taurus (Bovine) - BRIX1 gene Required for biogenesis of the 60S ribosomal subunit. Taurus_UMD|evm.model.AC_000177.1.288 Q5R7X9 RAD1_PONAB 96.071 0.992857 0.992908 RAD1 - Cell cycle checkpoint protein RAD1 - Pongo abelii (Sumatran orangutan) - RAD1 gene Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Possesses 3'->5' double-stranded DNA exonuclease activity (By similarity). Taurus_UMD|evm.model.AC_000177.1.289 A6H7D1 TT23L_BOVIN 80.198 0.673378 1.41905 TTC23L - Tetratricopeptide repeat protein 23-like - Bos taurus (Bovine) - TTC23L gene Taurus_UMD|evm.model.AC_000177.1.290 Q9P0K7 RAI14_HUMAN 92.449 0.997961 1.00102 RAI14 - Ankycorbin - Homo sapiens (Human) - RAI14 gene Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. Taurus_UMD|evm.model.AC_000177.1.292 Q9BXJ4 C1QT3_HUMAN 98.630 0.68125 1.30081 C1QTNF3 - Complement C1q tumor necrosis factor-related protein 3 precursor - Homo sapiens (Human) - C1QTNF3 gene extracellular exosome, membrane, identical protein binding, cellular triglyceride homeostasis, fat cell differentiation, negative regulation of gene expression, negative regulation of gluconeogenesis, negative regulation of inflammatory response, negative regulation of interleukin-6 production, negative regulation of monocyte chemotactic protein-1 production Taurus_UMD|evm.model.AC_000177.1.293 Q9UHK6 AMACR_HUMAN 84.293 0.994778 1.00262 AMACR - Alpha-methylacyl-CoA racemase - Homo sapiens (Human) - AMACR gene Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:7649182, PubMed:10655068, PubMed:11060359). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:7649182, PubMed:10655068, PubMed:11060359). Taurus_UMD|evm.model.AC_000177.1.294 P58355 S45A2_MOUSE 81.538 0.274468 0.886792 Slc45a2 - Membrane-associated transporter protein - Mus musculus (Mouse) - Slc45a2 gene Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity). Taurus_UMD|evm.model.AC_000177.1.295 Q9NSD7 RL3R1_HUMAN 89.738 0.995643 0.978678 RXFP3 - Relaxin-3 receptor 1 - Homo sapiens (Human) - RXFP3 gene Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation. Taurus_UMD|evm.model.AC_000177.1.297 P58397 ATS12_HUMAN 82.317 0.88587 0.115433 ADAMTS12 - A disintegrin and metalloproteinase with thrombospondin motifs 12 precursor - Homo sapiens (Human) - ADAMTS12 gene Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. Taurus_UMD|evm.model.AC_000177.1.298 Q6XXL8 DYLT3_SHEEP 96.552 0.982906 1.00862 DYNLT3 - Dynein light chain Tctex-type 3 - Ovis aries (Sheep) - DYNLT3 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity). Taurus_UMD|evm.model.AC_000177.1.299 P58397 ATS12_HUMAN 71.664 0.9861 0.767252 ADAMTS12 - A disintegrin and metalloproteinase with thrombospondin motifs 12 precursor - Homo sapiens (Human) - ADAMTS12 gene Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. Taurus_UMD|evm.model.AC_000177.1.300 Q3ZBV8 SYTC_BOVIN 100.000 0.997238 1.00138 TARS1 - Threonine--tRNA ligase 1, cytoplasmic - Bos taurus (Bovine) - TARS1 gene Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage. Taurus_UMD|evm.model.AC_000177.1.301 P10730 ANPRC_BOVIN 98.485 0.172872 0.700186 NPR3 - Atrial natriuretic peptide receptor 3 precursor - Bos taurus (Bovine) - NPR3 gene Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. Taurus_UMD|evm.model.AC_000177.1.302 Q5R6D0 TCP4_PONAB 99.213 0.984375 1.00787 SUB1 - Activated RNA polymerase II transcriptional coactivator p15 - Pongo abelii (Sumatran orangutan) - SUB1 gene General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA) (By similarity). Taurus_UMD|evm.model.AC_000177.1.303 Q96KR1 ZFR_HUMAN 98.541 0.989392 0.965549 ZFR - Zinc finger RNA-binding protein - Homo sapiens (Human) - ZFR gene Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). Taurus_UMD|evm.model.AC_000177.1.304 Q9C0I1 MTMRC_HUMAN 89.388 0.944659 1.04016 MTMR12 - Myotubularin-related protein 12 - Homo sapiens (Human) - MTMR12 gene Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity). Taurus_UMD|evm.model.AC_000177.1.305 P32394 HMOX1_PIG 48.333 0.856061 0.458333 HMOX1 - Heme oxygenase 1 - Sus scrofa (Pig) - HMOX1 gene Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. Taurus_UMD|evm.model.AC_000177.1.306 Q9ERE4 GOLP3_RAT 97.987 0.993311 1.00336 Golph3 - Golgi phosphoprotein 3 - Rattus norvegicus (Rat) - Golph3 gene Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. Taurus_UMD|evm.model.AC_000177.1.307 O15018 PDZD2_HUMAN 88.685 0.120118 0.95597 PDZD2 - PDZ domain-containing protein 2 - Homo sapiens (Human) - PDZD2 gene cell-cell junction, centriolar satellite, cytoplasm, cytosol, endoplasmic reticulum, extracellular region, intracellular membrane-bounded organelle, nucleus, plasma membrane Taurus_UMD|evm.model.AC_000177.1.309 Q9ERE4 GOLP3_RAT 96.000 0.980198 0.338926 Golph3 - Golgi phosphoprotein 3 - Rattus norvegicus (Rat) - Golph3 gene Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. Taurus_UMD|evm.model.AC_000177.1.310 Q49AR2 CE022_HUMAN 87.045 0.988739 1.00452 C5orf22 - UPF0489 protein C5orf22 - Homo sapiens (Human) - C5orf22 gene Taurus_UMD|evm.model.AC_000177.1.311 Q9NRR4 RNC_HUMAN 94.982 0.998506 0.974527 DROSHA - Ribonuclease 3 - Homo sapiens (Human) - DROSHA gene Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Taurus_UMD|evm.model.AC_000177.1.315 Q13813 SPTN1_HUMAN 94.643 0.956897 0.0469256 SPTAN1 - Spectrin alpha chain, non-erythrocytic 1 - Homo sapiens (Human) - SPTAN1 gene Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Taurus_UMD|evm.model.AC_000177.1.316 Q5R893 H2B1_PONAB 89.381 0.918033 0.968254 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000177.1.317 Q641Z6 EHD1_RAT 63.934 0.689655 0.162921 Ehd1 - EH domain-containing protein 1 - Rattus norvegicus (Rat) - Ehd1 gene ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (By similarity). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (By similarity). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (PubMed:23572513). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (By similarity). Taurus_UMD|evm.model.AC_000177.1.319 Q9ULB4 CADH9_HUMAN 96.417 0.94453 0.82256 CDH9 - Cadherin-9 precursor - Homo sapiens (Human) - CDH9 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Taurus_UMD|evm.model.AC_000177.1.320 Q1XFL1 ZAR1L_BOVIN 100.000 0.984064 0.789308 ZAR1L - ZAR1-like protein - Bos taurus (Bovine) - ZAR1L gene cytoplasm, mRNA binding involved in posttranscriptional gene silencing, translation Taurus_UMD|evm.model.AC_000177.1.321 Q9Y6N8 CAD10_HUMAN 98.223 0.997465 1.00127 CDH10 - Cadherin-10 precursor - Homo sapiens (Human) - CDH10 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Taurus_UMD|evm.model.AC_000177.1.323 P10768 ESTD_HUMAN 85.870 0.633803 0.503546 ESD - S-formylglutathione hydrolase - Homo sapiens (Human) - ESD gene Serine hydrolase involved in the detoxification of formaldehyde. Taurus_UMD|evm.model.AC_000177.1.325 P55289 CAD12_HUMAN 89.556 0.994695 0.949622 CDH12 - Cadherin-12 precursor - Homo sapiens (Human) - CDH12 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Taurus_UMD|evm.model.AC_000177.1.326 A4FUH0 RL22L_BOVIN 86.486 0.894309 1.0082 RPL22L1 - 60S ribosomal protein L22-like 1 - Bos taurus (Bovine) - RPL22L1 gene RNA binding, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000177.1.327 Q08DJ5 CAD18_BOVIN 100.000 0.997472 1.00127 CDH18 - Cadherin-18 precursor - Bos taurus (Bovine) - CDH18 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). Taurus_UMD|evm.model.AC_000177.1.329 Q9N0X0 AURKB_PIG 54.348 0.443299 0.563953 AURKB - Aurora kinase B - Sus scrofa (Pig) - AURKB gene Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Taurus_UMD|evm.model.AC_000177.1.330 Q9Y597 KCTD3_HUMAN 89.048 0.889362 0.288344 KCTD3 - BTB/POZ domain-containing protein KCTD3 - Homo sapiens (Human) - KCTD3 gene Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. Taurus_UMD|evm.model.AC_000177.1.331 Q9H6Y7 RN167_HUMAN 75.075 0.937853 1.01143 RNF167 - E3 ubiquitin-protein ligase RNF167 precursor - Homo sapiens (Human) - RNF167 gene May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition. Taurus_UMD|evm.model.AC_000177.1.332 A6NLC8 YE016_HUMAN 57.558 0.818182 1.05556 Putative TAF11-like protein ENSP00000332601 - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000177.1.333 P02350 RS31_XENLA 43.889 0.984615 0.528455 rps3-a - 40S ribosomal protein S3-A - Xenopus laevis (African clawed frog) - rps3-a gene Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Also involved in other processes including regulation of transcription, translation of its cognate mRNA, spindle formation and chromosome movement during mitosis, and apoptosis. Taurus_UMD|evm.model.AC_000177.1.334 P80724 BASP1_BOVIN 100.000 0.555556 0.713656 BASP1 - Brain acid soluble protein 1 - Bos taurus (Bovine) - BASP1 gene cytoplasm, nuclear speck, nucleus, transcription corepressor activity, transcription regulatory region sequence-specific DNA binding, negative regulation of transcription, DNA-templated Taurus_UMD|evm.model.AC_000177.1.336 P79114 MYO10_BOVIN 99.903 0.999026 1.00049 MYO10 - Unconventional myosin-X - Bos taurus (Bovine) - MYO10 gene In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation (By similarity). Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate, which are then moved relative to actin filaments. Stimulates the formation and elongation of filopodia. Regulates cell shape, cell spreading and cell adhesion. Plays a role in formation of the podosome belt in osteoclasts. Taurus_UMD|evm.model.AC_000177.1.337 Q5E9K8 RETR1_BOVIN 100.000 0.994681 0.762677 RETREG1 - Reticulophagy regulator 1 - Bos taurus (Bovine) - RETREG1 gene Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons. Taurus_UMD|evm.model.AC_000177.1.338 Q969S3 ZN622_HUMAN 82.600 0.925049 1.06289 ZNF622 - Zinc finger protein 622 - Homo sapiens (Human) - ZNF622 gene May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development. Taurus_UMD|evm.model.AC_000177.1.339 A6NNE9 MARHB_HUMAN 99.057 0.621302 0.420398 MARCHF11 - E3 ubiquitin-protein ligase MARCHF11 - Homo sapiens (Human) - MARCHF11 gene E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids. Taurus_UMD|evm.model.AC_000177.1.340 Q9UJT9 FBXL7_HUMAN 97.699 0.995825 0.97556 FBXL7 - F-box/LRR-repeat protein 7 - Homo sapiens (Human) - FBXL7 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:25778398). During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (By similarity). It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 (PubMed:25778398, PubMed:28218735). Taurus_UMD|evm.model.AC_000177.1.341 Q08DK4 GHC1_BOVIN 95.413 0.972973 0.34472 SLC25A22 - Mitochondrial glutamate carrier 1 - Bos taurus (Bovine) - SLC25A22 gene Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+) (By similarity). Taurus_UMD|evm.model.AC_000177.1.342 Q9HCJ1 ANKH_HUMAN 98.577 0.995943 1.00203 ANKH - Progressive ankylosis protein homolog - Homo sapiens (Human) - ANKH gene Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. Taurus_UMD|evm.model.AC_000177.1.343 Q96BN8 OTUL_HUMAN 88.636 0.994334 1.00284 OTULIN - Ubiquitin thioesterase otulin - Homo sapiens (Human) - OTULIN gene Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:26997266, PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327, PubMed:28919039). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling (PubMed:23806334). Taurus_UMD|evm.model.AC_000177.1.344 Q9NUU6 OTULL_HUMAN 87.640 0.994366 0.997191 OTULINL - Inactive ubiquitin thioesterase OTULINL - Homo sapiens (Human) - OTULINL gene Lacks deubiquitinase activity. Taurus_UMD|evm.model.AC_000177.1.345 O75962 TRIO_HUMAN 91.795 0.999324 0.955441 TRIO - Triple functional domain protein - Homo sapiens (Human) - TRIO gene Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:22155786, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). Taurus_UMD|evm.model.AC_000177.1.347 Q8TE73 DYH5_HUMAN 89.698 0.999729 0.797145 DNAH5 - Dynein axonemal heavy chain 5 - Homo sapiens (Human) - DNAH5 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles. Taurus_UMD|evm.model.AC_000177.1.349 Q8WU90 ZC3HF_HUMAN 78.313 0.584416 0.542254 ZC3H15 - Zinc finger CCCH domain-containing protein 15 - Homo sapiens (Human) - ZC3H15 gene Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). Taurus_UMD|evm.model.AC_000177.1.351 Q5EAE6 DAP1_BOVIN 100.000 0.980583 1.0098 DAP - Death-associated protein 1 - Bos taurus (Bovine) - DAP gene Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). Taurus_UMD|evm.model.AC_000177.1.352 Q3U0L2 AN33B_MOUSE 79.184 0.99591 1.00617 Ankrd33b - Ankyrin repeat domain-containing protein 33B - Mus musculus (Mouse) - Ankrd33b gene Taurus_UMD|evm.model.AC_000177.1.353 Q3T024 ROP1L_BOVIN 99.541 0.990868 1.00459 ROPN1L - Ropporin-1-like protein - Bos taurus (Bovine) - ROPN1L gene Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. Taurus_UMD|evm.model.AC_000177.1.354 O60337 MARH6_HUMAN 98.352 0.997805 1.0011 MARCHF6 - E3 ubiquitin-protein ligase MARCHF6 - Homo sapiens (Human) - MARCHF6 gene E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation (PubMed:15673284). Promotes ubiquitination of DIO2, leading to its degradation (PubMed:19651899). Promotes ubiquitination of SQLE, leading to its degradation (PubMed:24449766). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1 (PubMed:15673284). Taurus_UMD|evm.model.AC_000177.1.355 Q96DG6 CMBL_HUMAN 87.347 0.99187 1.00408 CMBL - Carboxymethylenebutenolidase homolog - Homo sapiens (Human) - CMBL gene Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. Taurus_UMD|evm.model.AC_000177.1.356 Q4R6V2 TCPE_MACFA 97.412 0.99631 1.00185 CCT5 - T-complex protein 1 subunit epsilon - Macaca fascicularis (Crab-eating macaque) - CCT5 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Taurus_UMD|evm.model.AC_000177.1.357 Q6P4H8 ACKMT_HUMAN 83.258 0.990991 0.95279 ATPSCKMT - ATP synthase subunit C lysine N-methyltransferase - Homo sapiens (Human) - ATPSCKMT gene Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (PubMed:29444090, PubMed:30530489). Promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090). Taurus_UMD|evm.model.AC_000177.1.361 Q13591 SEM5A_HUMAN 93.482 0.998138 1 SEMA5A - Semaphorin-5A precursor - Homo sapiens (Human) - SEMA5A gene Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. Taurus_UMD|evm.model.AC_000177.1.362 Q4JIJ2 MTRR_BOVIN 99.856 0.997126 1.00144 MTRR - Methionine synthase reductase - Bos taurus (Bovine) - MTRR gene Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin. Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (By similarity). Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme. Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme (By similarity). Taurus_UMD|evm.model.AC_000177.1.363 Q58CX2 FAKD3_BOVIN 100.000 0.825 1.15152 FASTKD3 - FAST kinase domain-containing protein 3, mitochondrial precursor - Bos taurus (Bovine) - FASTKD3 gene Required for normal mitochondrial respiration. Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity. Taurus_UMD|evm.model.AC_000177.1.364 A4QMS7 CE049_HUMAN 79.592 0.915094 0.721088 C5orf49 - Uncharacterized protein C5orf49 - Homo sapiens (Human) - C5orf49 gene ciliary basal body Taurus_UMD|evm.model.AC_000177.1.365 Q08462 ADCY2_HUMAN 98.256 0.895288 0.175069 ADCY2 - Adenylate cyclase type 2 - Homo sapiens (Human) - ADCY2 gene Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). Taurus_UMD|evm.model.AC_000177.1.366 P07435 OBP_BOVIN 50.968 0.777778 1.24528 Odorant-binding protein - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000177.1.368 Q5XG87 PAPD7_HUMAN 90.557 0.929088 0.895078 TENT4A - Terminal nucleotidyltransferase 4A - Homo sapiens (Human) - TENT4A gene Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:23376078, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (PubMed:23376078). Taurus_UMD|evm.model.AC_000177.1.369 A5PJS2 S5A1_BOVIN 100.000 0.992248 1.00389 SRD5A1 - 3-oxo-5-alpha-steroid 4-dehydrogenase 1 - Bos taurus (Bovine) - SRD5A1 gene Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Taurus_UMD|evm.model.AC_000177.1.370 Q08J23 NSUN2_HUMAN 83.091 0.970437 1.01434 NSUN2 - RNA cytosine C(5)-methyltransferase NSUN2 - Homo sapiens (Human) - NSUN2 gene RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31358969, PubMed:31199786). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). Taurus_UMD|evm.model.AC_000177.1.371 A0PJN4 U2QL1_MOUSE 97.727 0.796296 0.335404 Ube2ql1 - Ubiquitin-conjugating enzyme E2Q-like protein 1 - Mus musculus (Mouse) - Ube2ql1 gene Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7. Taurus_UMD|evm.model.AC_000177.1.372 Q5R6P5 MED10_PONAB 100.000 0.985294 1.00741 MED10 - Mediator of RNA polymerase II transcription subunit 10 - Pongo abelii (Sumatran orangutan) - MED10 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Taurus_UMD|evm.model.AC_000177.1.374 Q86SX6 GLRX5_HUMAN 77.922 0.95 0.509554 GLRX5 - Glutaredoxin-related protein 5, mitochondrial precursor - Homo sapiens (Human) - GLRX5 gene Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:20364084, PubMed:23615440). Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:20364084, PubMed:23615440, PubMed:24334290). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084). Taurus_UMD|evm.model.AC_000177.1.377 O15439 MRP4_HUMAN 71.429 0.425439 0.172075 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000177.1.380 Q9Y2F5 ICE1_HUMAN 58.655 0.99909 0.96955 ICE1 - Little elongation complex subunit 1 - Homo sapiens (Human) - ICE1 gene Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). Taurus_UMD|evm.model.AC_000177.1.382 Q8TE57 ATS16_HUMAN 75.138 0.95122 0.770425 ADAMTS16 - A disintegrin and metalloproteinase with thrombospondin motifs 16 precursor - Homo sapiens (Human) - ADAMTS16 gene extracellular matrix, metalloendopeptidase activity, extracellular matrix organization Taurus_UMD|evm.model.AC_000177.1.383 Q8TE57 ATS16_HUMAN 76.730 0.940476 0.137255 ADAMTS16 - A disintegrin and metalloproteinase with thrombospondin motifs 16 precursor - Homo sapiens (Human) - ADAMTS16 gene extracellular matrix, metalloendopeptidase activity, extracellular matrix organization Taurus_UMD|evm.model.AC_000177.1.392 P78414 IRX1_HUMAN 90.062 0.995807 0.99375 IRX1 - Iroquois-class homeodomain protein IRX-1 - Homo sapiens (Human) - IRX1 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, cell development, negative regulation of transcription by RNA polymerase II, neuron differentiation Taurus_UMD|evm.model.AC_000177.1.401 Q9BZI1 IRX2_HUMAN 90.547 0.735294 0.577495 IRX2 - Iroquois-class homeodomain protein IRX-2 - Homo sapiens (Human) - IRX2 gene chromatin, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, cell development, negative regulation of transcription by RNA polymerase II, neuron differentiation, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000177.1.420 P78413 IRX4_HUMAN 85.333 0.996176 1.00771 IRX4 - Iroquois-class homeodomain protein IRX-4 - Homo sapiens (Human) - IRX4 gene Likely to be an important mediator of ventricular differentiation during cardiac development. Taurus_UMD|evm.model.AC_000177.1.422 P23934 NDUS6_BOVIN 100.000 0.984 1.00806 NDUFS6 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor - Bos taurus (Bovine) - NDUFS6 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000177.1.423 Q1LWG3 RM36_DANRE 60.000 0.435644 0.87069 mrpl36 - 39S ribosomal protein L36, mitochondrial precursor - Danio rerio (Zebrafish) - mrpl36 gene mitochondrial large ribosomal subunit, ribosome biogenesis Taurus_UMD|evm.model.AC_000177.1.426 Q8NF37 PCAT1_HUMAN 84.865 0.531025 1.29775 LPCAT1 - Lysophosphatidylcholine acyltransferase 1 - Homo sapiens (Human) - LPCAT1 gene Exhibits acyltransferase activity (PubMed:21498505, PubMed:18156367). Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505, PubMed:18156367). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198). Taurus_UMD|evm.model.AC_000177.1.427 P27922 SC6A3_BOVIN 85.246 0.902077 0.486291 SLC6A3 - Sodium-dependent dopamine transporter - Bos taurus (Bovine) - SLC6A3 gene Amine transporter (PubMed:1722321). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). Taurus_UMD|evm.model.AC_000177.1.428 P27922 SC6A3_BOVIN 100.000 0.530435 0.33189 SLC6A3 - Sodium-dependent dopamine transporter - Bos taurus (Bovine) - SLC6A3 gene Amine transporter (PubMed:1722321). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). Taurus_UMD|evm.model.AC_000177.1.429 P27922 SC6A3_BOVIN 99.296 0.564 0.36075 SLC6A3 - Sodium-dependent dopamine transporter - Bos taurus (Bovine) - SLC6A3 gene Amine transporter (PubMed:1722321). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). Taurus_UMD|evm.model.AC_000177.1.431 A2VE61 CLP1L_BOVIN 99.814 0.996289 1.00186 CLPTM1L - Cleft lip and palate transmembrane protein 1-like protein - Bos taurus (Bovine) - CLPTM1L gene Enhances cisplatin-mediated apoptosis, when overexpressed. Taurus_UMD|evm.model.AC_000177.1.432 Q27ID4 TERT_BOVIN 99.876 0.625681 1.14222 TERT - Telomerase reverse transcriptase - Bos taurus (Bovine) - TERT gene Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis (By similarity). Taurus_UMD|evm.model.AC_000177.1.434 Q96N87 S6A18_HUMAN 76.858 0.957861 0.982484 SLC6A18 - Inactive sodium-dependent neutral amino acid transporter B(0)AT3 - Homo sapiens (Human) - SLC6A18 gene Does not show neutral amino acid transporter activity. Taurus_UMD|evm.model.AC_000177.1.435 Q2A865 S6A19_RAT 79.528 0.993388 0.954259 Slc6a19 - Sodium-dependent neutral amino acid transporter B(0)AT1 - Rattus norvegicus (Rat) - Slc6a19 gene Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride-independent. Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity. Taurus_UMD|evm.model.AC_000177.1.436 Q7YRU6 S12A7_RABIT 79.716 0.942803 0.948463 SLC12A7 - Solute carrier family 12 member 7 - Oryctolagus cuniculus (Rabbit) - SLC12A7 gene Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). Taurus_UMD|evm.model.AC_000177.1.437 Q969F2 NKD2_HUMAN 76.307 0.729592 0.86918 NKD2 - Protein naked cuticle homolog 2 - Homo sapiens (Human) - NKD2 gene Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. Taurus_UMD|evm.model.AC_000177.1.440 D3K5L7 PCH2_PIG 95.370 0.995381 1.00464 TRIP13 - Pachytene checkpoint protein 2 homolog - Sus scrofa (Pig) - TRIP13 gene Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Plays a role in mitotic spindle assembly checkpoint (SAC) activation (By similarity). Taurus_UMD|evm.model.AC_000177.1.441 Q9H8M2 BRD9_HUMAN 88.312 0.995138 1.0335 BRD9 - Bromodomain-containing protein 9 - Homo sapiens (Human) - BRD9 gene Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Orchestrates also the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312). Taurus_UMD|evm.model.AC_000177.1.444 Q27957 TPPP_BOVIN 100.000 0.990868 1.00459 TPPP - Tubulin polymerization-promoting protein - Bos taurus (Bovine) - TPPP gene Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (By similarity). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (By similarity). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (By similarity). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (By similarity). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:14623963). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (By similarity). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (By similarity). Plays a role in cell proliferation by regulating the G1/S-phase transition (By similarity). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (By similarity). Taurus_UMD|evm.model.AC_000177.1.445 Q14AK4 ZDH11_MOUSE 61.751 0.62029 0.994236 Zdhhc11 - Palmitoyltransferase ZDHHC11 - Mus musculus (Mouse) - Zdhhc11 gene Endoplasmic reticulum-localized palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (PubMed:23687301). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (PubMed:23687301). May play a role in cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000177.1.446 Q9P209 CEP72_HUMAN 66.038 0.971246 0.967543 CEP72 - Centrosomal protein of 72 kDa - Homo sapiens (Human) - CEP72 gene Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Taurus_UMD|evm.model.AC_000177.1.449 P48764 SL9A3_HUMAN 88.738 0.962919 1.0024 SLC9A3 - Sodium/hydrogen exchanger 3 - Homo sapiens (Human) - SLC9A3 gene Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction. Taurus_UMD|evm.model.AC_000177.1.450 Q0V8C2 EXOC3_BOVIN 100.000 0.997319 1.00134 EXOC3 - Exocyst complex component 3 - Bos taurus (Bovine) - EXOC3 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Taurus_UMD|evm.model.AC_000177.1.451 A9YTQ3 AHRR_HUMAN 49.206 0.859189 0.597718 AHRR - Aryl hydrocarbon receptor repressor - Homo sapiens (Human) - AHRR gene Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. Taurus_UMD|evm.model.AC_000177.1.452 A9YTQ3 AHRR_HUMAN 66.474 0.924731 0.265335 AHRR - Aryl hydrocarbon receptor repressor - Homo sapiens (Human) - AHRR gene Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. Taurus_UMD|evm.model.AC_000177.1.453 A9YTQ3 AHRR_HUMAN 86.301 0.266667 0.385164 AHRR - Aryl hydrocarbon receptor repressor - Homo sapiens (Human) - AHRR gene Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. Taurus_UMD|evm.model.AC_000177.1.455 P01865 GCAM_MOUSE 65.586 0.922535 1.07035 Igh-1a - Ig gamma-2A chain C region, membrane-bound form - Mus musculus (Mouse) - Igh-1a gene external side of plasma membrane, immunoglobulin complex, circulating, multivesicular body, antigen binding, immunoglobulin receptor binding, antibody-dependent cellular cytotoxicity, antigen processing and presentation, B cell receptor signaling pathway, complement activation, classical pathway, defense response to bacterium Taurus_UMD|evm.model.AC_000177.1.456 P12815 PDCD6_MOUSE 97.906 0.632997 1.55497 Pdcd6 - Programmed cell death protein 6 - Mus musculus (Mouse) - Pdcd6 gene Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair (PubMed:10744743, PubMed:11525164, PubMed:27541325). Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:10744743, PubMed:11525164, PubMed:27541325). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:10744743, PubMed:11525164, PubMed:27541325). Together with PEF1, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (By similarity). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (By similarity). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (By similarity). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (By similarity). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (PubMed:8560270). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (By similarity). Its role in apoptosis may however be indirect, as suggested by knockout experiments (PubMed:12024023). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (By similarity). Taurus_UMD|evm.model.AC_000177.1.457 P31039 SDHA_BOVIN 99.098 0.996997 1.0015 SDHA - Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor - Bos taurus (Bovine) - SDHA gene Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable). Can act as a tumor suppressor (By similarity). Taurus_UMD|evm.model.AC_000177.1.459 P0C267 CC127_PIG 89.535 0.992278 1.00388 CCDC127 - Coiled-coil domain-containing protein 127 - Sus scrofa (Pig) - CCDC127 gene Taurus_UMD|evm.model.AC_000177.1.460 A6NHZ5 LR14B_HUMAN 79.843 0.996094 0.996109 LRRC14B - Leucine-rich repeat-containing protein 14B - Homo sapiens (Human) - LRRC14B gene cytoplasm Taurus_UMD|evm.model.AC_000178.1.1 Q9XS96 SNURF_BOVIN 92.857 0.219048 4.43662 SNURF - SNRPN upstream reading frame protein - Bos taurus (Bovine) - SNURF gene nuclear speck Taurus_UMD|evm.model.AC_000178.1.4 Q99608 NECD_HUMAN 87.730 0.993865 1.01558 NDN - Necdin - Homo sapiens (Human) - NDN gene Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity). Taurus_UMD|evm.model.AC_000178.1.5 Q9UJ55 MAGL2_HUMAN 70.515 0.638146 0.898319 MAGEL2 - MAGE-like protein 2 - Homo sapiens (Human) - MAGEL2 gene Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly (PubMed:23452853). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK (By similarity). Taurus_UMD|evm.model.AC_000178.1.6 Q13064 MKRN3_HUMAN 65.344 0.957983 0.938856 MKRN3 - Probable E3 ubiquitin-protein ligase makorin-3 - Homo sapiens (Human) - MKRN3 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Taurus_UMD|evm.model.AC_000178.1.11 A6NC57 ANR62_HUMAN 50.725 0.0793839 0.920393 ANKRD62 - Ankyrin repeat domain-containing protein 62 - Homo sapiens (Human) - ANKRD62 gene Taurus_UMD|evm.model.AC_000178.1.12 Q13136 LIPA1_HUMAN 44.904 0.900181 0.458403 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000178.1.13 Q13136 LIPA1_HUMAN 70.968 0.772152 0.0657238 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000178.1.14 O75335 LIPA4_HUMAN 52.703 0.243333 0.253165 PPFIA4 - Liprin-alpha-4 - Homo sapiens (Human) - PPFIA4 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity). Taurus_UMD|evm.model.AC_000178.1.15 Q13136 LIPA1_HUMAN 77.500 0.410526 0.0790349 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000178.1.16 Q13136 LIPA1_HUMAN 75.000 0.410526 0.0790349 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000178.1.17 Q61086 FZD3_MOUSE 89.937 0.428184 0.554054 Fzd3 - Frizzled-3 precursor - Mus musculus (Mouse) - Fzd3 gene Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner. Taurus_UMD|evm.model.AC_000178.1.18 Q13136 LIPA1_HUMAN 68.182 0.162907 0.331947 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000178.1.19 Q9UPS8 ANR26_HUMAN 74.118 0.246009 0.805848 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000178.1.20 Q9D6Y1 CCDC3_MOUSE 67.033 0.74359 0.857143 Ccdc3 - Coiled-coil domain-containing protein 3 precursor - Mus musculus (Mouse) - Ccdc3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (By similarity). Positively regulates lipid accumulation in adipose cells (PubMed:25605713). Taurus_UMD|evm.model.AC_000178.1.21 Q9UPS8 ANR26_HUMAN 80.702 0.934066 0.106433 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000178.1.22 O75334 LIPA2_HUMAN 48.000 0.397608 0.53222 PPFIA2 - Liprin-alpha-2 - Homo sapiens (Human) - PPFIA2 gene Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165). Taurus_UMD|evm.model.AC_000178.1.23 Q13136 LIPA1_HUMAN 65.823 0.557143 0.116473 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000178.1.24 Q13136 LIPA1_HUMAN 54.762 0.259424 0.375208 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000178.1.25 Q13136 LIPA1_HUMAN 88.235 0.33 0.0831947 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000178.1.26 Q13136 LIPA1_HUMAN 51.439 0.451128 0.442596 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000178.1.27 Q13136 LIPA1_HUMAN 71.845 0.185118 0.458403 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000178.1.28 Q13136 LIPA1_HUMAN 69.748 0.624339 0.157238 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000178.1.31 Q05086 UBE3A_HUMAN 97.133 0.993151 1.00114 UBE3A - Ubiquitin-protein ligase E3A - Homo sapiens (Human) - UBE3A gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990). Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PubMed:16772533). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (By similarity). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). Taurus_UMD|evm.model.AC_000178.1.34 O60312 AT10A_HUMAN 81.419 0.985215 0.992662 ATP10A - Phospholipid-transporting ATPase VA - Homo sapiens (Human) - ATP10A gene Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane (PubMed:25947375, PubMed:29599178, PubMed:30530492). Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking (PubMed:29599178). Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix (PubMed:29599178, PubMed:25947375). Has low flippase activity toward glucosylceramide (GlcCer) (PubMed:30530492). Taurus_UMD|evm.model.AC_000178.1.40 P28472 GBRB3_HUMAN 97.215 0.822176 1.01057 GABRB3 - Gamma-aminobutyric acid receptor subunit beta-3 precursor - Homo sapiens (Human) - GABRB3 gene Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:18514161, PubMed:22303015, PubMed:26950270, PubMed:22243422, PubMed:24909990). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity (PubMed:25489750). The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). Plays an important role in somatosensation and in the production of antinociception (By similarity). Taurus_UMD|evm.model.AC_000178.1.42 Q08E50 GBRA5_BOVIN 100.000 0.99568 1.00216 GABRA5 - Gamma-aminobutyric acid receptor subunit alpha-5 precursor - Bos taurus (Bovine) - GABRA5 gene Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse. Taurus_UMD|evm.model.AC_000178.1.43 P97351 RS3A_MOUSE 91.045 0.673469 0.371212 Rps3a - 40S ribosomal protein S3a - Mus musculus (Mouse) - Rps3a gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Taurus_UMD|evm.model.AC_000178.1.44 Q5R893 H2B1_PONAB 91.270 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000178.1.46 Q99928 GBRG3_HUMAN 62.209 0.733813 0.892934 GABRG3 - Gamma-aminobutyric acid receptor subunit gamma-3 precursor - Homo sapiens (Human) - GABRG3 gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Taurus_UMD|evm.model.AC_000178.1.47 Q2TBY0 SKA2_BOVIN 93.388 0.983607 1.00826 SKA2 - Spindle and kinetochore-associated protein 2 - Bos taurus (Bovine) - SKA2 gene Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. Taurus_UMD|evm.model.AC_000178.1.48 Q2KI76 SELS_BOVIN 100.000 0.989418 0.994737 SELENOS - Selenoprotein S - Bos taurus (Bovine) - SELENOS gene Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity). Taurus_UMD|evm.model.AC_000178.1.49 Q86X52 CHSS1_HUMAN 96.139 0.997512 1.00249 CHSY1 - Chondroitin sulfate synthase 1 - Homo sapiens (Human) - CHSY1 gene Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling. Taurus_UMD|evm.model.AC_000178.1.50 Q38SD2 LRRK1_HUMAN 89.087 0.999008 1.0005 LRRK1 - Leucine-rich repeat serine/threonine-protein kinase 1 - Homo sapiens (Human) - LRRK1 gene cytoplasm, cytosol, intracellular membrane-bounded organelle, mitochondrion, identical protein binding, protein serine/threonine phosphatase activity, positive regulation of canonical Wnt signaling pathway, signal transduction Taurus_UMD|evm.model.AC_000178.1.51 P47895 AL1A3_HUMAN 85.741 0.9375 1.09375 ALDH1A3 - Aldehyde dehydrogenase family 1 member A3 - Homo sapiens (Human) - ALDH1A3 gene NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid (PubMed:27759097). Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (PubMed:27759097). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity). Taurus_UMD|evm.model.AC_000178.1.52 P01819 HVM43_MOUSE 66.364 0.631579 1.1875 Ig heavy chain V region MOPC 141 precursor - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000178.1.53 Q9H672 ASB7_HUMAN 100.000 0.83378 1.17296 ASB7 - Ankyrin repeat and SOCS box protein 7 - Homo sapiens (Human) - ASB7 gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000178.1.54 Q8NG48 LINES_HUMAN 72.751 0.993412 1.00264 LINS1 - Protein Lines homolog 1 - Homo sapiens (Human) - LINS1 gene cognition Taurus_UMD|evm.model.AC_000178.1.55 Q8IU89 CERS3_HUMAN 73.252 0.993528 0.806789 CERS3 - Ceramide synthase 3 - Homo sapiens (Human) - CERS3 gene Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) and ultra long chain (more than C26:0) as acyl donor (PubMed:17977534, PubMed:22038835, PubMed:26887952). It is crucial for the synthesis of ultra long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:23754960). Taurus_UMD|evm.model.AC_000178.1.56 Q8TE56 ATS17_HUMAN 84.017 0.994676 1.02922 ADAMTS17 - A disintegrin and metalloproteinase with thrombospondin motifs 17 precursor - Homo sapiens (Human) - ADAMTS17 gene extracellular matrix, metalloendopeptidase activity, extracellular matrix organization Taurus_UMD|evm.model.AC_000178.1.58 Q5REP3 LYSM4_PONAB 78.351 0.864865 0.375 LYSMD4 - LysM and putative peptidoglycan-binding domain-containing protein 4 - Pongo abelii (Sumatran orangutan) - LYSMD4 gene Taurus_UMD|evm.model.AC_000178.1.59 Q5REP3 LYSM4_PONAB 76.442 0.683168 1.02365 LYSMD4 - LysM and putative peptidoglycan-binding domain-containing protein 4 - Pongo abelii (Sumatran orangutan) - LYSMD4 gene Taurus_UMD|evm.model.AC_000178.1.60 Q5REW7 MEF2A_PONAB 95.749 0.995927 0.993927 MEF2A - Myocyte-specific enhancer factor 2A - Pongo abelii (Sumatran orangutan) - MEF2A gene Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation.Associates with chromatin to the ZNF16 promoter (By similarity). Taurus_UMD|evm.model.AC_000178.1.61 Q32KX5 LRC28_BOVIN 99.728 0.994565 1.00272 LRRC28 - Leucine-rich repeat-containing protein 28 - Bos taurus (Bovine) - LRRC28 gene Taurus_UMD|evm.model.AC_000178.1.62 Q2KHY7 TTC23_BOVIN 99.552 0.995526 1.00224 TTC23 - Tetratricopeptide repeat protein 23 - Bos taurus (Bovine) - TTC23 gene Partcipates positively in the ciliary Hedgehog (Hh) signaling. Taurus_UMD|evm.model.AC_000178.1.63 O15061 SYNEM_HUMAN 72.987 0.908944 0.792971 SYNM - Synemin - Homo sapiens (Human) - SYNM gene Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. Taurus_UMD|evm.model.AC_000178.1.65 P08069 IGF1R_HUMAN 96.262 0.581967 0.26774 IGF1R - Insulin-like growth factor 1 receptor precursor - Homo sapiens (Human) - IGF1R gene Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R. Taurus_UMD|evm.model.AC_000178.1.69 Q05688 IGF1R_BOVIN 100.000 0.541067 1.84531 IGF1R - Insulin-like growth factor 1 receptor precursor - Bos taurus (Bovine) - IGF1R gene Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R (By similarity). When present in a hybrid receptor with INSR, binds IGF1 (By similarity). Taurus_UMD|evm.model.AC_000178.1.70 Q9CWB5 PGPIL_MOUSE 74.016 0.642857 1.50769 Pgpep1l - Pyroglutamyl-peptidase 1-like protein - Mus musculus (Mouse) - Pgpep1l gene proteolysis Taurus_UMD|evm.model.AC_000178.1.71 Q8N8A8 F169B_HUMAN 78.195 0.416404 1.65104 FAM169B - Protein FAM169B - Homo sapiens (Human) - FAM169B gene Taurus_UMD|evm.model.AC_000178.1.74 Q8NCT1 ARRD4_HUMAN 91.408 0.995169 0.990431 ARRDC4 - Arrestin domain-containing protein 4 - Homo sapiens (Human) - ARRDC4 gene Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake (PubMed:19605364). Taurus_UMD|evm.model.AC_000178.1.75 O15439 MRP4_HUMAN 68.401 0.6875 0.289811 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.AC_000178.1.76 O75529 TAF5L_HUMAN 60.870 0.695175 0.774194 TAF5L - TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L - Homo sapiens (Human) - TAF5L gene Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By similarity). Taurus_UMD|evm.model.AC_000178.1.78 Q9TTR7 COT2_BOVIN 100.000 0.995181 1.00242 NR2F2 - COUP transcription factor 2 - Bos taurus (Bovine) - NR2F2 gene Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development. Taurus_UMD|evm.model.AC_000178.1.85 Q6DN12 MCTP2_HUMAN 90.444 0.997725 1.00114 MCTP2 - Multiple C2 and transmembrane domain-containing protein 2 - Homo sapiens (Human) - MCTP2 gene Might play a role in the development of cardiac outflow tract. Taurus_UMD|evm.model.AC_000178.1.87 P48305 NDUB4_BOVIN 92.248 0.984615 1.00775 NDUFB4 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 - Bos taurus (Bovine) - NDUFB4 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000178.1.88 Q3MHM7 RL35_BOVIN 98.374 0.983871 1.00813 RPL35 - 60S ribosomal protein L35 - Bos taurus (Bovine) - RPL35 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000178.1.90 Q96B86 RGMA_HUMAN 91.071 0.905093 0.96 RGMA - Repulsive guidance molecule A precursor - Homo sapiens (Human) - RGMA gene Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. Taurus_UMD|evm.model.AC_000178.1.93 Q8CEZ0 KCTD2_MOUSE 62.353 0.394366 0.800752 Kctd2 - BTB/POZ domain-containing protein KCTD2 - Mus musculus (Mouse) - Kctd2 gene Cul3-RING ubiquitin ligase complex, cytoplasm, cullin family protein binding, protein-containing complex binding, proteasome-mediated ubiquitin-dependent protein catabolic process Taurus_UMD|evm.model.AC_000178.1.94 Q1RMK9 F174B_BOVIN 99.180 0.930769 0.81761 FAM174B - Membrane protein FAM174B precursor - Bos taurus (Bovine) - FAM174B gene Essential for Golgi structural integrity. Taurus_UMD|evm.model.AC_000178.1.95 P61643 SIA8B_PANTR 100.000 0.372 0.666667 ST8SIA2 - Alpha-2,8-sialyltransferase 8B - Pan troglodytes (Chimpanzee) - ST8SIA2 gene May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression. Taurus_UMD|evm.model.AC_000178.1.96 Q9UIG8 SO3A1_HUMAN 96.222 0.861804 0.733803 SLCO3A1 - Solute carrier organic anion transporter family member 3A1 - Homo sapiens (Human) - SLCO3A1 gene Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3-sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491). Taurus_UMD|evm.model.AC_000178.1.99 Q8HYW2 SO3A1_BOVIN 100.000 0.873469 0.34507 SLCO3A1 - Solute carrier organic anion transporter family member 3A1 - Bos taurus (Bovine) - SLCO3A1 gene Mediates the Na(+)-independent transport of organic anions. Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin. Taurus_UMD|evm.model.AC_000178.1.100 Q12802 AKP13_HUMAN 85.463 0.937759 0.0856737 AKAP13 - A-kinase anchor protein 13 - Homo sapiens (Human) - AKAP13 gene Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). Taurus_UMD|evm.model.AC_000178.1.101 Q7L1I2 SV2B_HUMAN 95.022 0.997076 1.00146 SV2B - Synaptic vesicle glycoprotein 2B - Homo sapiens (Human) - SV2B gene Probably plays a role in the control of regulated secretion in neural and endocrine cells. Taurus_UMD|evm.model.AC_000178.1.102 Q12802 AKP13_HUMAN 67.592 0.971624 0.989691 AKAP13 - A-kinase anchor protein 13 - Homo sapiens (Human) - AKAP13 gene Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). Taurus_UMD|evm.model.AC_000178.1.104 Q9H0H3 KLH25_HUMAN 95.586 0.99661 1.0017 KLHL25 - Kelch-like protein 25 - Homo sapiens (Human) - KLHL25 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. Taurus_UMD|evm.model.AC_000178.1.106 B2RD01 CENP1_HUMAN 35.185 0.340984 1.63102 CENPBD1 - CENPB DNA-binding domain-containing protein 1 - Homo sapiens (Human) - CENPBD1 gene Taurus_UMD|evm.model.AC_000178.1.107 Q96MI9 CBPC4_HUMAN 56.452 0.822917 0.0863309 AGBL1 - Cytosolic carboxypeptidase 4 - Homo sapiens (Human) - AGBL1 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Taurus_UMD|evm.model.AC_000178.1.108 Q96MI9 CBPC4_HUMAN 75.947 0.885926 0.607014 AGBL1 - Cytosolic carboxypeptidase 4 - Homo sapiens (Human) - AGBL1 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Taurus_UMD|evm.model.AC_000178.1.109 Q96MI9 CBPC4_HUMAN 95.082 0.810811 0.0665468 AGBL1 - Cytosolic carboxypeptidase 4 - Homo sapiens (Human) - AGBL1 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Taurus_UMD|evm.model.AC_000178.1.110 P49441 INPP_HUMAN 74.725 0.387931 0.581454 INPP1 - Inositol polyphosphate 1-phosphatase - Homo sapiens (Human) - INPP1 gene cytosol, inositol-1,4-bisphosphate 1-phosphatase activity, inositol phosphate dephosphorylation, inositol phosphate metabolic process, phosphate-containing compound metabolic process, signal transduction Taurus_UMD|evm.model.AC_000178.1.111 Q09M05 CBPC4_MOUSE 92.381 0.66242 0.139929 Agbl1 - Cytosolic carboxypeptidase 4 - Mus musculus (Mouse) - Agbl1 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Taurus_UMD|evm.model.AC_000178.1.112 Q09M05 CBPC4_MOUSE 63.768 0.701031 0.0864528 Agbl1 - Cytosolic carboxypeptidase 4 - Mus musculus (Mouse) - Agbl1 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Taurus_UMD|evm.model.AC_000178.1.114 Q09M05 CBPC4_MOUSE 59.016 0.536364 0.0980392 Agbl1 - Cytosolic carboxypeptidase 4 - Mus musculus (Mouse) - Agbl1 gene Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Taurus_UMD|evm.model.AC_000178.1.115 Q10126 YSM6_CAEEL 27.461 0.767544 0.817204 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000178.1.117 Q5IS37 NTRK3_PANTR 100.000 0.973597 0.367273 NTRK3 - NT-3 growth factor receptor precursor - Pan troglodytes (Chimpanzee) - NTRK3 gene Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Taurus_UMD|evm.model.AC_000178.1.118 Q16288 NTRK3_HUMAN 97.393 0.801905 0.625745 NTRK3 - NT-3 growth factor receptor precursor - Homo sapiens (Human) - NTRK3 gene Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Taurus_UMD|evm.model.AC_000178.1.119 Q5IS82 NTRK3_SAIBB 100.000 0.383178 0.259394 NTRK3 - NT-3 growth factor receptor precursor - Saimiri boliviensis boliviensis (Bolivian squirrel monkey) - NTRK3 gene Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Taurus_UMD|evm.model.AC_000178.1.120 Q3SZ22 RM46_BOVIN 99.639 0.992806 1.00361 MRPL46 - 39S ribosomal protein L46, mitochondrial precursor - Bos taurus (Bovine) - MRPL46 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000178.1.121 P82911 RT11_BOVIN 82.741 0.987879 0.837563 MRPS11 - 28S ribosomal protein S11, mitochondrial precursor - Bos taurus (Bovine) - MRPS11 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation, peptide biosynthetic process Taurus_UMD|evm.model.AC_000178.1.122 Q9D0A0 DET1_MOUSE 98.909 0.915 1.09091 Det1 - DET1 homolog - Mus musculus (Mouse) - Det1 gene Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation (By similarity). Taurus_UMD|evm.model.AC_000178.1.123 Q5REE2 AEN_PONAB 80.923 0.987805 1.00923 AEN - Apoptosis-enhancing nuclease - Pongo abelii (Sumatran orangutan) - AEN gene Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis (By similarity). Taurus_UMD|evm.model.AC_000178.1.124 Q96AZ6 ISG20_HUMAN 79.290 0.976744 0.950276 ISG20 - Interferon-stimulated gene 20 kDa protein - Homo sapiens (Human) - ISG20 gene Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis. Taurus_UMD|evm.model.AC_000178.1.125 Q5R6H1 MYADM_PONAB 51.724 0.336788 2.39752 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.126 Q5R6H1 MYADM_PONAB 62.182 0.832827 1.02174 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.127 Q96S97 MYADM_HUMAN 48.182 0.486607 0.695652 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.128 Q5R6H1 MYADM_PONAB 51.034 0.941176 0.369565 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.129 Q5R6H1 MYADM_PONAB 36.398 0.654179 1.07764 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.130 Q5R6H1 MYADM_PONAB 61.011 0.634483 1.35093 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.131 Q5R6H1 MYADM_PONAB 53.061 0.218182 0.68323 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.132 Q5R6H1 MYADM_PONAB 51.292 0.820669 1.02174 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.133 Q5R6H1 MYADM_PONAB 56.827 0.891089 0.940994 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.134 Q5R6H1 MYADM_PONAB 41.892 0.461538 0.686335 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.135 Q96S97 MYADM_HUMAN 51.818 0.325373 1.04037 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.136 Q5R6H1 MYADM_PONAB 39.474 0.54 1.08696 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.137 Q5R6H1 MYADM_PONAB 56.716 0.803681 1.01242 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.139 Q5R6H1 MYADM_PONAB 60.289 0.932432 0.919255 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.140 Q96S97 MYADM_HUMAN 53.782 0.640884 0.562112 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.141 Q5R6H1 MYADM_PONAB 53.875 0.828221 1.01242 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.142 O35682 MYADM_MOUSE 67.391 0.3125 0.45 Myadm - Myeloid-associated differentiation marker - Mus musculus (Mouse) - Myadm gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.143 Q5R6H1 MYADM_PONAB 44.980 0.814815 0.754658 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.144 Q96S97 MYADM_HUMAN 60.440 0.86901 0.97205 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.145 Q5R6H1 MYADM_PONAB 43.110 0.905405 0.919255 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.146 Q96S97 MYADM_HUMAN 60.791 0.92953 0.925466 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.147 Q96S97 MYADM_HUMAN 56.039 0.82 0.776398 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.148 Q5R6H1 MYADM_PONAB 55.952 0.826733 0.627329 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.149 Q5R6H1 MYADM_PONAB 62.667 0.662222 0.698758 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.150 Q96S97 MYADM_HUMAN 64.469 0.896667 0.931677 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.151 Q5R6H1 MYADM_PONAB 60.791 0.92953 0.925466 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.152 Q96S97 MYADM_HUMAN 70.251 0.873016 0.978261 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.153 Q5R6H1 MYADM_PONAB 60.584 0.873786 0.959627 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.154 Q5R6H1 MYADM_PONAB 61.957 0.895765 0.953416 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.155 Q5R6H1 MYADM_PONAB 53.135 0.970149 0.832298 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.156 Q96S97 MYADM_HUMAN 64.260 0.596112 1.43789 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.157 Q96S97 MYADM_HUMAN 60.573 0.887097 0.962733 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.158 Q96S97 MYADM_HUMAN 60.215 0.887097 0.962733 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.159 Q5R6H1 MYADM_PONAB 58.182 0.79562 0.425466 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.160 Q5R6H1 MYADM_PONAB 55.952 0.910112 0.829193 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.161 Q96S97 MYADM_HUMAN 61.905 0.86859 0.968944 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.162 Q96S97 MYADM_HUMAN 41.700 0.873362 0.71118 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.163 Q96S97 MYADM_HUMAN 61.151 0.882166 0.975155 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.164 Q96S97 MYADM_HUMAN 59.206 0.851852 1.00621 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.165 Q96S97 MYADM_HUMAN 61.372 0.881789 0.97205 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.166 Q96S97 MYADM_HUMAN 59.206 0.851852 1.00621 MYADM - Myeloid-associated differentiation marker - Homo sapiens (Human) - MYADM gene cell-cell junction, cortical actin cytoskeleton, membrane raft, plasma membrane, ruffle, establishment of endothelial barrier, membrane raft organization, negative regulation of actin filament polymerization, negative regulation of gene expression, negative regulation of heterotypic cell-cell adhesion Taurus_UMD|evm.model.AC_000178.1.167 Q5R6H1 MYADM_PONAB 66.423 0.944637 0.897516 MYADM - Myeloid-associated differentiation marker - Pongo abelii (Sumatran orangutan) - MYADM gene Taurus_UMD|evm.model.AC_000178.1.168 P13608 PGCA_BOVIN 99.704 0.999155 1.00127 ACAN - Aggrecan core protein precursor - Bos taurus (Bovine) - ACAN gene This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. Taurus_UMD|evm.model.AC_000178.1.169 Q96S86 HPLN3_HUMAN 82.456 0.944598 1.00278 HAPLN3 - Hyaluronan and proteoglycan link protein 3 precursor - Homo sapiens (Human) - HAPLN3 gene May function in hyaluronic acid binding. Taurus_UMD|evm.model.AC_000178.1.170 Q95114 MFGM_BOVIN 98.608 0.99537 1.01171 MFGE8 - Lactadherin precursor - Bos taurus (Bovine) - MFGE8 gene Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Taurus_UMD|evm.model.AC_000178.1.172 Q5EA42 ABHD2_BOVIN 100.000 0.948546 1.05176 ABHD2 - Monoacylglycerol lipase ABHD2 - Bos taurus (Bovine) - ABHD2 gene Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (By similarity). May also play a role in smooth muscle cells migration (By similarity). Taurus_UMD|evm.model.AC_000178.1.173 P10123 RLBP1_BOVIN 97.887 0.734375 0.605678 RLBP1 - Retinaldehyde-binding protein 1 - Bos taurus (Bovine) - RLBP1 gene Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'. Taurus_UMD|evm.model.AC_000178.1.174 Q9NVI1 FANCI_HUMAN 84.807 0.989458 1 FANCI - Fanconi anemia group I protein - Homo sapiens (Human) - FANCI gene Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage. Taurus_UMD|evm.model.AC_000178.1.175 P54098 DPOG1_HUMAN 87.925 0.998358 0.983051 POLG - DNA polymerase subunit gamma-1 - Homo sapiens (Human) - POLG gene Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA. Taurus_UMD|evm.model.AC_000178.1.176 P10123 RLBP1_BOVIN 100.000 0.828571 0.662461 RLBP1 - Retinaldehyde-binding protein 1 - Bos taurus (Bovine) - RLBP1 gene Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'. Taurus_UMD|evm.model.AC_000178.1.177 Q2T9S6 RHCG_BOVIN 97.452 0.995763 1.02609 RHCG - Ammonium transporter Rh type C - Bos taurus (Bovine) - RHCG gene Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion (By similarity). Taurus_UMD|evm.model.AC_000178.1.178 Q7Z2Z1 TICRR_HUMAN 71.904 0.998424 0.996335 TICRR - Treslin - Homo sapiens (Human) - TICRR gene Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. Taurus_UMD|evm.model.AC_000178.1.179 Q2M1P5 KIF7_HUMAN 89.778 0.985391 1.01936 KIF7 - Kinesin-like protein KIF7 - Homo sapiens (Human) - KIF7 gene Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). Taurus_UMD|evm.model.AC_000178.1.180 O60240 PLIN1_HUMAN 84.483 0.996132 0.990421 PLIN1 - Perilipin-1 - Homo sapiens (Human) - PLIN1 gene Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. Taurus_UMD|evm.model.AC_000178.1.181 Q0VCP2 PX11A_BOVIN 100.000 0.991935 1.00405 PEX11A - Peroxisomal membrane protein 11A - Bos taurus (Bovine) - PEX11A gene May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface. Taurus_UMD|evm.model.AC_000178.1.182 Q6P2C0 WDR93_HUMAN 72.203 0.574219 0.746356 WDR93 - WD repeat-containing protein 93 - Homo sapiens (Human) - WDR93 gene mitochondrial respiratory chain complex I Taurus_UMD|evm.model.AC_000178.1.184 Q0VG99 MESP2_HUMAN 63.333 0.994872 0.982368 MESP2 - Mesoderm posterior protein 2 - Homo sapiens (Human) - MESP2 gene Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Taurus_UMD|evm.model.AC_000178.1.185 P79098 AMPN_BOVIN 99.689 0.99793 1.00104 ANPEP - Aminopeptidase N - Bos taurus (Bovine) - ANPEP gene Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity). Taurus_UMD|evm.model.AC_000178.1.187 Q1JQA3 AP3S2_BOVIN 81.347 0.987342 0.818653 AP3S2 - AP-3 complex subunit sigma-2 - Bos taurus (Bovine) - AP3S2 gene Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). Taurus_UMD|evm.model.AC_000178.1.188 Q17QU3 ARPIN_BOVIN 100.000 0.991189 1.00442 ARPIN - Arpin - Bos taurus (Bovine) - ARPIN gene Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence (By similarity). Taurus_UMD|evm.model.AC_000178.1.189 Q8N1W2 ZN710_HUMAN 94.578 0.996992 1.00151 ZNF710 - Zinc finger protein 710 - Homo sapiens (Human) - ZNF710 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000178.1.190 Q04467 IDHP_BOVIN 100.000 0.995585 1.00221 IDH2 - Isocitrate dehydrogenase [NADP], mitochondrial precursor - Bos taurus (Bovine) - IDH2 gene Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. Taurus_UMD|evm.model.AC_000178.1.191 P62890 RL30_RAT 79.130 0.982759 1.0087 Rpl30 - 60S ribosomal protein L30 - Rattus norvegicus (Rat) - Rpl30 gene cytosol, cytosolic large ribosomal subunit, nucleus, polysomal ribosome, postsynaptic density, ribosome, RNA binding, selenocysteine insertion sequence binding, structural constituent of ribosome, antimicrobial humoral immune response mediated by antimicrobial peptide Taurus_UMD|evm.model.AC_000178.1.192 Q9NPR2 SEM4B_HUMAN 81.407 0.957524 0.984468 SEMA4B - Semaphorin-4B precursor - Homo sapiens (Human) - SEMA4B gene Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. Taurus_UMD|evm.model.AC_000178.1.193 B1A8Z2 CIB1_SHEEP 100.000 0.989583 1.00524 CIB1 - Calcium and integrin-binding protein 1 - Ovis aries (Sheep) - CIB1 gene Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells (By similarity). Taurus_UMD|evm.model.AC_000178.1.194 Q5E9T1 GDPP1_BOVIN 100.000 0.994819 1.0026 GDPGP1 - GDP-D-glucose phosphorylase 1 - Bos taurus (Bovine) - GDPGP1 gene Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. Taurus_UMD|evm.model.AC_000178.1.195 A4Q9F6 TTL13_MOUSE 60.606 0.340314 0.237562 Ttll13 - Tubulin polyglutamylase TTLL13 - Mus musculus (Mouse) - Ttll13 gene Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Taurus_UMD|evm.model.AC_000178.1.196 Q2HJC0 NGRN_BOVIN 100.000 0.993056 1.00348 NGRN - Neugrin precursor - Bos taurus (Bovine) - NGRN gene Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. Taurus_UMD|evm.model.AC_000178.1.197 Q2HJ18 VP33B_BOVIN 100.000 0.996764 1.00162 VPS33B - Vacuolar protein sorting-associated protein 33B - Bos taurus (Bovine) - VPS33B gene May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity. Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity). Taurus_UMD|evm.model.AC_000178.1.198 O43663 PRC1_HUMAN 83.871 0.996491 0.919355 PRC1 - Protein regulator of cytokinesis 1 - Homo sapiens (Human) - PRC1 gene Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). Taurus_UMD|evm.model.AC_000178.1.199 Q4R828 RCCD1_MACFA 79.947 0.994709 1.00532 RCCD1 - RCC1 domain-containing protein 1 - Macaca fascicularis (Crab-eating macaque) - RCCD1 gene Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8. Taurus_UMD|evm.model.AC_000178.1.200 Q9H3U1 UN45A_HUMAN 94.486 0.996825 1.00106 UNC45A - Protein unc-45 homolog A - Homo sapiens (Human) - UNC45A gene Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity). Taurus_UMD|evm.model.AC_000178.1.201 Q3SXP7 SHSL1_HUMAN 32.184 0.5 0.854271 SHISAL1 - Protein shisa-like-1 precursor - Homo sapiens (Human) - SHISAL1 gene Taurus_UMD|evm.model.AC_000178.1.202 Q8N4P3 MESH1_HUMAN 93.855 0.988889 1.00559 HDDC3 - Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 - Homo sapiens (Human) - HDDC3 gene ppGpp hydrolyzing enzyme involved in starvation response. Taurus_UMD|evm.model.AC_000178.1.203 P49641 MA2A2_HUMAN 92.087 0.565731 1.76609 MAN2A2 - Alpha-mannosidase 2x - Homo sapiens (Human) - MAN2A2 gene Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. Taurus_UMD|evm.model.AC_000178.1.204 Q28193 FURIN_BOVIN 99.749 0.997494 1.00125 FURIN - Furin precursor - Bos taurus (Bovine) - FURIN gene Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:7806563). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity). Taurus_UMD|evm.model.AC_000178.1.205 P54132 BLM_HUMAN 81.774 0.998602 1.00988 BLM - Bloom syndrome protein - Homo sapiens (Human) - BLM gene ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:9388193, PubMed:24816114, PubMed:25901030). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (PubMed:20639533, PubMed:24257077, PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). Taurus_UMD|evm.model.AC_000178.1.206 Q6UUV7 CRTC3_HUMAN 87.500 0.962649 0.951535 CRTC3 - CREB-regulated transcription coactivator 3 - Homo sapiens (Human) - CRTC3 gene Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). Taurus_UMD|evm.model.AC_000178.1.207 P46940 IQGA1_HUMAN 96.341 0.98854 1.0006 IQGAP1 - Ras GTPase-activating-like protein IQGAP1 - Homo sapiens (Human) - IQGAP1 gene Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). Taurus_UMD|evm.model.AC_000178.1.208 Q6NX45 ZN774_HUMAN 93.089 0.782748 0.648033 ZNF774 - Zinc finger protein 774 - Homo sapiens (Human) - ZNF774 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000178.1.209 Q7Z7L9 ZSCA2_HUMAN 88.455 0.857542 1.16612 ZSCAN2 - Zinc finger and SCAN domain-containing protein 2 - Homo sapiens (Human) - ZSCAN2 gene May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis. Taurus_UMD|evm.model.AC_000178.1.210 Q6P4I2 WDR73_HUMAN 80.688 0.994609 0.981481 WDR73 - WD repeat-containing protein 73 - Homo sapiens (Human) - WDR73 gene May play a role in the regulation of microtubule organization and dynamics (PubMed:25466283). Taurus_UMD|evm.model.AC_000178.1.211 Q2T9U8 NMB_BOVIN 98.198 0.859375 1.05785 NMB - Neuromedin-B precursor - Bos taurus (Bovine) - NMB gene Stimulates smooth muscle contraction in a manner similar to that of bombesin. Taurus_UMD|evm.model.AC_000178.1.212 Q5R9C7 SC11A_PONAB 100.000 0.988889 1.00559 SEC11A - Signal peptidase complex catalytic subunit SEC11A - Pongo abelii (Sumatran orangutan) - SEC11A gene Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Taurus_UMD|evm.model.AC_000178.1.213 Q92610 ZN592_HUMAN 86.745 0.99842 0.999211 ZNF592 - Zinc finger protein 592 - Homo sapiens (Human) - ZNF592 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000178.1.214 Q96L96 ALPK3_HUMAN 75.569 0.974329 0.898794 ALPK3 - Alpha-protein kinase 3 - Homo sapiens (Human) - ALPK3 gene Involved in cardiomyocyte differentiation. Taurus_UMD|evm.model.AC_000178.1.215 O62667 S28A1_PIG 89.669 0.50104 0.743431 SLC28A1 - Sodium/nucleoside cotransporter 1 - Sus scrofa (Pig) - SLC28A1 gene Sodium-dependent and pyrimidine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). Transports uridine, cytidine, thymidine, and nucleoside-derived drugs. Transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). Taurus_UMD|evm.model.AC_000178.1.216 P52732 KIF11_HUMAN 92.754 0.747253 0.0861742 KIF11 - Kinesin-like protein KIF11 - Homo sapiens (Human) - KIF11 gene Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). Taurus_UMD|evm.model.AC_000178.1.218 O60658 PDE8A_HUMAN 86.364 0.997599 1.00483 PDE8A - High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A - Homo sapiens (Human) - PDE8A gene Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299). Taurus_UMD|evm.model.AC_000178.1.219 Q6QAP7 RS17_PIG 100.000 0.650485 1.52593 RPS17 - 40S ribosomal protein S17 - Sus scrofa (Pig) - RPS17 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit Taurus_UMD|evm.model.AC_000178.1.220 Q5R733 CPEB1_PONAB 98.354 0.782258 1.27572 CPEB1 - Cytoplasmic polyadenylation element-binding protein 1 - Pongo abelii (Sumatran orangutan) - CPEB1 gene Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry. Taurus_UMD|evm.model.AC_000178.1.221 Q9JME5 AP3B2_MOUSE 98.983 0.632597 1.0037 Ap3b2 - AP-3 complex subunit beta-2 - Mus musculus (Mouse) - Ap3b2 gene Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Taurus_UMD|evm.model.AC_000178.1.223 A1L4K1 FSD2_HUMAN 85.306 0.974633 1 FSD2 - Fibronectin type III and SPRY domain-containing protein 2 - Homo sapiens (Human) - FSD2 gene nucleus, perinuclear region of cytoplasm, sarcoplasmic reticulum Taurus_UMD|evm.model.AC_000178.1.224 Q1A5X7 WHAL1_HUMAN 82.301 0.138958 5.26797 WHAMMP3 - Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1 - Homo sapiens (Human) - WHAMMP3 gene cytoplasm, endoplasmic reticulum-Golgi intermediate compartment membrane, Arp2/3 complex binding, Arp2/3 complex-mediated actin nucleation, cell cycle arrest, endoplasmic reticulum to Golgi vesicle-mediated transport Taurus_UMD|evm.model.AC_000178.1.225 Q9NSB8 HOME2_HUMAN 93.503 0.994186 0.971751 HOMER2 - Homer protein homolog 2 - Homo sapiens (Human) - HOMER2 gene Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). Taurus_UMD|evm.model.AC_000178.1.226 Q5R9Q6 RAMAC_PONAB 93.220 0.983193 1.00847 RAMAC - RNA guanine-N7 methyltransferase activating subunit - Pongo abelii (Sumatran orangutan) - RAMAC gene Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT. Regulates RNMT expression by a post-transcriptional stabilizing mechanism. Binds RNA. Taurus_UMD|evm.model.AC_000178.1.227 Q3ZBP8 CO040_BOVIN 96.721 0.909774 1.05556 UPF0235 protein C15orf40 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000178.1.230 P82987 ATL3_HUMAN 72.581 0.204698 0.176227 ADAMTSL3 - ADAMTS-like protein 3 precursor - Homo sapiens (Human) - ADAMTSL3 gene extracellular matrix, intracellular membrane-bounded organelle, metalloendopeptidase activity, extracellular matrix organization Taurus_UMD|evm.model.AC_000178.1.231 Q9NR30 DDX21_HUMAN 67.347 0.852174 0.440613 DDX21 - Nucleolar RNA helicase 2 - Homo sapiens (Human) - DDX21 gene RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Taurus_UMD|evm.model.AC_000178.1.232 O00370 LORF2_HUMAN 28.641 0.766284 0.204706 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000178.1.233 Q6ZN04 MEX3B_HUMAN 94.989 0.995652 0.808436 MEX3B - RNA-binding protein MEX3B - Homo sapiens (Human) - MEX3B gene RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms. Taurus_UMD|evm.model.AC_000178.1.234 Q3UE17 MEX3D_MOUSE 100.000 0.130208 0.2986 Mex3d - RNA-binding protein MEX3D - Mus musculus (Mouse) - Mex3d gene RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. Taurus_UMD|evm.model.AC_000178.1.235 Q7Z2Z2 EFL1_HUMAN 91.851 0.99823 1.00893 EFL1 - Elongation factor-like GTPase 1 - Homo sapiens (Human) - EFL1 gene Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits. Taurus_UMD|evm.model.AC_000178.1.236 Q658L1 SAXO2_HUMAN 75.389 0.846154 1.14322 SAXO2 - Stabilizer of axonemal microtubules 2 - Homo sapiens (Human) - SAXO2 gene axonemal microtubule, centriole, ciliary basal body, cytoskeleton, sperm flagellum, microtubule binding, microtubule anchoring Taurus_UMD|evm.model.AC_000178.1.237 P82987 ATL3_HUMAN 79.119 0.975873 0.931402 ADAMTSL3 - ADAMTS-like protein 3 precursor - Homo sapiens (Human) - ADAMTSL3 gene extracellular matrix, intracellular membrane-bounded organelle, metalloendopeptidase activity, extracellular matrix organization Taurus_UMD|evm.model.AC_000178.1.238 Q99963 SH3G3_HUMAN 94.306 0.915033 0.881844 SH3GL3 - Endophilin-A3 - Homo sapiens (Human) - SH3GL3 gene Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Taurus_UMD|evm.model.AC_000178.1.239 Q01954 BNC1_HUMAN 83.047 0.947047 0.987928 BNC1 - Zinc finger protein basonuclin-1 - Homo sapiens (Human) - BNC1 gene Transcriptional activator (By similarity). It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles (PubMed:8034748). Required for the maintenance of spermatogenesis (By similarity). It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade (PubMed:30010909). May also play a role in the early development of embryos (By similarity). Taurus_UMD|evm.model.AC_000178.1.240 Q9Y3E1 HDGR3_HUMAN 99.507 0.990196 1.00493 HDGFL3 - Hepatoma-derived growth factor-related protein 3 - Homo sapiens (Human) - HDGFL3 gene Enhances DNA synthesis and may play a role in cell proliferation. Taurus_UMD|evm.model.AC_000178.1.241 A6QL84 TM6S1_BOVIN 99.730 0.994609 1.0027 TM6SF1 - Transmembrane 6 superfamily member 1 - Bos taurus (Bovine) - TM6SF1 gene May function as sterol isomerase. Taurus_UMD|evm.model.AC_000178.1.242 Q9H0C5 BTBD1_HUMAN 96.273 0.995859 1.00207 BTBD1 - BTB/POZ domain-containing protein 1 - Homo sapiens (Human) - BTBD1 gene Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). Taurus_UMD|evm.model.AC_000178.1.243 P68370 TBA1A_RAT 89.877 0.966752 0.866962 Tuba1a - Tubulin alpha-1A chain - Rattus norvegicus (Rat) - Tuba1a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Taurus_UMD|evm.model.AC_000178.1.244 P60762 MO4L1_MOUSE 98.343 0.99449 1.00276 Morf4l1 - Mortality factor 4-like protein 1 - Mus musculus (Mouse) - Morf4l1 gene Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci (By similarity). Taurus_UMD|evm.model.AC_000178.1.245 Q3T0I2 CATH_BOVIN 100.000 0.994048 1.00299 CTSH - Pro-cathepsin H precursor - Bos taurus (Bovine) - CTSH gene Important for the overall degradation of proteins in lysosomes. Taurus_UMD|evm.model.AC_000178.1.246 Q13972 RGRF1_HUMAN 94.266 0.998386 0.973291 RASGRF1 - Ras-specific guanine nucleotide-releasing factor 1 - Homo sapiens (Human) - RASGRF1 gene Promotes the exchange of Ras-bound GDP by GTP. Taurus_UMD|evm.model.AC_000178.1.247 P0C6C1 AN34C_HUMAN 88.060 0.996269 1.00187 ANKRD34C - Ankyrin repeat domain-containing protein 34C - Homo sapiens (Human) - ANKRD34C gene Taurus_UMD|evm.model.AC_000178.1.248 Q9Y3Q3 TMED3_HUMAN 90.826 0.990868 1.00922 TMED3 - Transmembrane emp24 domain-containing protein 3 precursor - Homo sapiens (Human) - TMED3 gene Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. Taurus_UMD|evm.model.AC_000178.1.250 Q9UPX6 MNAR1_HUMAN 90.185 0.997821 1.00218 MINAR1 - Major intrinsically disordered Notch2-binding receptor 1 - Homo sapiens (Human) - MINAR1 gene Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR (PubMed:30080879). Negatively regulates angiogenesis (PubMed:29329397). Negatively regulates cell growth (PubMed:29329397, PubMed:30080879). Negatively regulates neurite outgrowth in hippocampal neurons (By similarity). Taurus_UMD|evm.model.AC_000178.1.252 P49914 MTHFS_HUMAN 83.920 0.980198 0.995074 MTHFS - 5-formyltetrahydrofolate cyclo-ligase - Homo sapiens (Human) - MTHFS gene Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate. Taurus_UMD|evm.model.AC_000178.1.253 Q3C2I0 B2LA1_BOVIN 100.000 0.988636 1.00571 BCL2A1 - Bcl-2-related protein A1 - Bos taurus (Bovine) - BCL2A1 gene Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity). Taurus_UMD|evm.model.AC_000178.1.254 Q0II44 S2541_BOVIN 93.333 0.502825 0.507163 SLC25A41 - Mitochondrial carrier protein SCaMC-3L - Bos taurus (Bovine) - SLC25A41 gene Calcium-independent ATP-Mg/Pi exchanger that catalyzes the electroneutral exchange of Mg-ATP or free ADP against an hydrogenphosphate and participates in the net transport of adenine nucleotides across the mitochondria inner membrane. Taurus_UMD|evm.model.AC_000178.1.255 Q3SZY7 ZFAN6_BOVIN 99.180 0.952756 0.610577 ZFAND6 - AN1-type zinc finger protein 6 - Bos taurus (Bovine) - ZFAND6 gene polyubiquitin modification-dependent protein binding, protein targeting to peroxisome Taurus_UMD|evm.model.AC_000178.1.256 A5PKH3 FAAA_BOVIN 99.761 0.995238 1.00239 FAH - Fumarylacetoacetase - Bos taurus (Bovine) - FAH gene fumarylacetoacetase activity, homogentisate catabolic process, L-phenylalanine catabolic process, tyrosine catabolic process Taurus_UMD|evm.model.AC_000178.1.257 A0A1B0GST9 CTXD1_MOUSE 98.305 0.966667 1.01695 Ctxnd1 - Cortexin domain-containing 1 - Mus musculus (Mouse) - Ctxnd1 gene Taurus_UMD|evm.model.AC_000178.1.258 Q9HBZ2 ARNT2_HUMAN 95.072 0.586621 0.81311 ARNT2 - Aryl hydrocarbon receptor nuclear translocator 2 - Homo sapiens (Human) - ARNT2 gene Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475). Specifically recognizes the xenobiotic response element (XRE). Taurus_UMD|evm.model.AC_000178.1.259 A5PKD9 AB17C_BOVIN 100.000 0.993939 1.00304 ABHD17C - Alpha/beta hydrolase domain-containing protein 17C - Bos taurus (Bovine) - ABHD17C gene Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95. Taurus_UMD|evm.model.AC_000178.1.260 Q8WUJ3 CEMIP_HUMAN 91.403 0.998532 1.00073 CEMIP - Cell migration-inducing and hyaluronan-binding protein precursor - Homo sapiens (Human) - CEMIP gene Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing. Taurus_UMD|evm.model.AC_000178.1.261 Q3T0U1 MESD_BOVIN 100.000 0.991416 1.00431 MESD - LRP chaperone MESD precursor - Bos taurus (Bovine) - MESD gene Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells. Taurus_UMD|evm.model.AC_000178.1.262 Q9H1K6 TLRN1_HUMAN 98.343 0.99449 1.00276 TLNRD1 - Talin rod domain-containing protein 1 - Homo sapiens (Human) - TLNRD1 gene Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. Taurus_UMD|evm.model.AC_000178.1.263 Q6P656 CF161_HUMAN 81.633 0.909938 1.06977 CFAP161 - Cilia- and flagella-associated protein 161 - Homo sapiens (Human) - CFAP161 gene May play a role in motile cilia function, possibly by acting on dynein arm assembly. Taurus_UMD|evm.model.AC_000178.1.264 Q8WUJ3 CEMIP_HUMAN 46.789 0.846774 0.0911095 CEMIP - Cell migration-inducing and hyaluronan-binding protein precursor - Homo sapiens (Human) - CEMIP gene Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing. Taurus_UMD|evm.model.AC_000178.1.265 Q0V8R5 IL16_BOVIN 100.000 0.464047 2.15152 IL16 - Pro-interleukin-16 - Bos taurus (Bovine) - IL16 gene Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4 (By similarity). Taurus_UMD|evm.model.AC_000178.1.266 A1A4M6 STAR5_BOVIN 100.000 0.990654 1.00469 STARD5 - StAR-related lipid transfer protein 5 - Bos taurus (Bovine) - STARD5 gene May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity). Taurus_UMD|evm.model.AC_000178.1.267 Q7Z5M5 TMC3_HUMAN 89.281 0.79572 0.934545 TMC3 - Transmembrane channel-like protein 3 - Homo sapiens (Human) - TMC3 gene Probable ion channel. Taurus_UMD|evm.model.AC_000178.1.268 O95478 NSA2_HUMAN 96.842 0.979167 0.369231 NSA2 - Ribosome biogenesis protein NSA2 homolog - Homo sapiens (Human) - NSA2 gene Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). Taurus_UMD|evm.model.AC_000178.1.269 Q2KIZ3 MCEE_BOVIN 100.000 0.966667 1.02857 MCEE - Methylmalonyl-CoA epimerase, mitochondrial precursor - Bos taurus (Bovine) - MCEE gene Methylmalonyl-CoA epimerase involved in propionyl-CoA metabolism. Taurus_UMD|evm.model.AC_000178.1.270 O00566 MPP10_HUMAN 81.936 0.997089 1.00881 MPHOSPH10 - U3 small nucleolar ribonucleoprotein protein MPP10 - Homo sapiens (Human) - MPHOSPH10 gene Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Taurus_UMD|evm.model.AC_000178.1.271 D2HNY3 FAN1_AILME 74.414 0.994141 0.999024 FAN1 - Fanconi-associated nuclease 1 - Ailuropoda melanoleuca (Giant panda) - FAN1 gene Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap. Also has endonuclease activity toward 5'-flaps. Taurus_UMD|evm.model.AC_000178.1.272 Q9NXD2 MTMRA_HUMAN 87.773 0.997386 0.984556 MTMR10 - Myotubularin-related protein 10 - Homo sapiens (Human) - MTMR10 gene cytoplasm, cytosol, phosphatidylinositol-3-phosphatase activity, phosphatidylinositol dephosphorylation Taurus_UMD|evm.model.AC_000178.1.273 Q7Z4N2 TRPM1_HUMAN 87.500 0.980344 1.0156 TRPM1 - Transient receptor potential cation channel subfamily M member 1 - Homo sapiens (Human) - TRPM1 gene Forms nonselective divalent cation-conducting channels which mediate the influx of Na(2+), Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization (PubMed:19436059, PubMed:21278253). Impermeable to zinc ions (PubMed:21278253). In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions (PubMed:21278253). Essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel. Taurus_UMD|evm.model.AC_000178.1.274 Q9Y2Y9 KLF13_HUMAN 97.917 0.805085 0.409722 KLF13 - Krueppel-like factor 13 - Homo sapiens (Human) - KLF13 gene Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells. Taurus_UMD|evm.model.AC_000178.1.275 Q6GQQ9 OTU7B_HUMAN 56.818 0.163498 0.311981 OTUD7B - OTU domain-containing protein 7B - Homo sapiens (Human) - OTUD7B gene Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin. Taurus_UMD|evm.model.AC_000178.1.276 P18621 RL17_HUMAN 80.978 0.987013 0.836957 RPL17 - 60S ribosomal protein L17 - Homo sapiens (Human) - RPL17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000178.1.277 Q99767 APBA2_HUMAN 88.845 0.923362 1.08011 APBA2 - Amyloid-beta A4 precursor protein-binding family A member 2 - Homo sapiens (Human) - APBA2 gene Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Taurus_UMD|evm.model.AC_000178.1.278 O60320 F1891_HUMAN 71.918 0.995402 0.80705 FAM189A1 - Protein FAM189A1 - Homo sapiens (Human) - FAM189A1 gene Taurus_UMD|evm.model.AC_000178.1.279 Q9CPR8 NSE3_MOUSE 79.570 0.961538 1.02509 Nsmce3 - Non-structural maintenance of chromosomes element 3 homolog - Mus musculus (Mouse) - Nsmce3 gene Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (PubMed:14593116). Taurus_UMD|evm.model.AC_000178.1.280 O60320 F1891_HUMAN 97.872 0.885714 0.194805 FAM189A1 - Protein FAM189A1 - Homo sapiens (Human) - FAM189A1 gene Taurus_UMD|evm.model.AC_000178.1.281 O97758 ZO1_CANLF 82.012 0.998837 0.971735 TJP1 - Tight junction protein ZO-1 - Canis lupus familiaris (Dog) - TJP1 gene TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:9792688, PubMed:10575001, PubMed:27802160). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (PubMed:27802160). Plays a role in the regulation of cell migration by targeting CDC42BPBb to the leading edge of migrating cells (By similarity). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (PubMed:24986862). Taurus_UMD|evm.model.AC_000178.1.286 A6QNM8 SYTC2_BOVIN 100.000 0.888889 1.10635 TARS3 - Threonine--tRNA ligase 2, cytoplasmic - Bos taurus (Bovine) - TARS3 gene Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage. Taurus_UMD|evm.model.AC_000178.1.287 Q9BRN9 TM2D3_HUMAN 86.111 0.992095 1.02429 TM2D3 - TM2 domain-containing protein 3 precursor - Homo sapiens (Human) - TM2D3 gene spanning component of plasma membrane, lateral inhibition, positive regulation of Notch signaling pathway Taurus_UMD|evm.model.AC_000178.1.288 P29122 PCSK6_HUMAN 91.379 0.995418 0.900929 PCSK6 - Proprotein convertase subtilisin/kexin type 6 precursor - Homo sapiens (Human) - PCSK6 gene Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues. Taurus_UMD|evm.model.AC_000178.1.289 Q4R8Y8 RU2A_MACFA 99.216 0.992188 1.00392 SNRPA1 - U2 small nuclear ribonucleoprotein A' - Macaca fascicularis (Crab-eating macaque) - SNRPA1 gene Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. Taurus_UMD|evm.model.AC_000178.1.290 Q9NQV7 PRDM9_HUMAN 61.517 0.730853 0.511186 PRDM9 - Histone-lysine N-methyltransferase PRDM9 - Homo sapiens (Human) - PRDM9 gene Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:24634223, PubMed:24095733, PubMed:26833727). Also can methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24095733, PubMed:24634223, PubMed:26833727). Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (By similarity). During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:26833727). Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (By similarity). During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema. EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity). In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (By similarity). Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (By similarity). In addition performs automethylation (By similarity). Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (By similarity). Taurus_UMD|evm.model.AC_000178.1.291 P54131 ACHA7_BOVIN 98.214 0.992386 0.789579 CHRNA7 - Neuronal acetylcholine receptor subunit alpha-7 precursor - Bos taurus (Bovine) - CHRNA7 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. Taurus_UMD|evm.model.AC_000178.1.292 P54131 ACHA7_BOVIN 100.000 0.655914 0.186373 CHRNA7 - Neuronal acetylcholine receptor subunit alpha-7 precursor - Bos taurus (Bovine) - CHRNA7 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. Taurus_UMD|evm.model.AC_000178.1.293 E2RSS3 WEE2_CANLF 67.241 0.483193 0.419753 WEE2 - Wee1-like protein kinase 2 - Canis lupus familiaris (Dog) - WEE2 gene Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity). Taurus_UMD|evm.model.AC_000178.1.294 Q5RBN9 TAD2B_PONAB 91.892 0.0983607 0.871429 TADA2B - Transcriptional adapter 2-beta - Pongo abelii (Sumatran orangutan) - TADA2B gene Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. Taurus_UMD|evm.model.AC_000178.1.296 P82915 RT16_BOVIN 73.636 0.981982 0.822222 MRPS16 - 28S ribosomal protein S16, mitochondrial precursor - Bos taurus (Bovine) - MRPS16 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000178.1.297 Q8TE49 OTU7A_HUMAN 79.730 0.953995 0.892009 OTUD7A - OTU domain-containing protein 7A - Homo sapiens (Human) - OTUD7A gene Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains. Taurus_UMD|evm.model.AC_000178.1.298 Q9NSD7 RL3R1_HUMAN 49.704 0.690205 0.936034 RXFP3 - Relaxin-3 receptor 1 - Homo sapiens (Human) - RXFP3 gene Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation. Taurus_UMD|evm.model.AC_000178.1.299 Q9UKP4 ATS7_HUMAN 78.218 0.946497 0.931198 ADAMTS7 - A disintegrin and metalloproteinase with thrombospondin motifs 7 precursor - Homo sapiens (Human) - ADAMTS7 gene Metalloprotease that may play a role in the degradation of COMP. Taurus_UMD|evm.model.AC_000178.1.300 Q9UPU7 TBD2B_HUMAN 84.552 0.977887 0.845275 TBC1D2B - TBC1 domain family member 2B - Homo sapiens (Human) - TBC1D2B gene May act as a GTPase-activating protein. Taurus_UMD|evm.model.AC_000178.1.301 A6NKC9 SH2D7_HUMAN 69.414 0.959574 1.04213 SH2D7 - SH2 domain-containing protein 7 - Homo sapiens (Human) - SH2D7 gene Taurus_UMD|evm.model.AC_000178.1.302 C7A276 CIB2_SHEEP 99.338 0.700935 1.21591 CIB2 - Calcium and integrin-binding family member 2 - Ovis aries (Sheep) - CIB2 gene Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release. May be involved in the mechanotransduction process. Taurus_UMD|evm.model.AC_000178.1.303 P41563 IDH3A_BOVIN 99.454 0.99455 1.00273 IDH3A - Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - IDH3A gene Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Taurus_UMD|evm.model.AC_000178.1.304 Q2KHW5 ACBG1_BOVIN 100.000 0.95788 1.01377 ACSBG1 - Long-chain-fatty-acid--CoA ligase ACSBG1 - Bos taurus (Bovine) - ACSBG1 gene Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. Taurus_UMD|evm.model.AC_000178.1.305 Q8WW22 DNJA4_HUMAN 95.184 0.832151 1.06549 DNAJA4 - DnaJ homolog subfamily A member 4 precursor - Homo sapiens (Human) - DNAJA4 gene cytosol, membrane, chaperone binding, unfolded protein binding, negative regulation of endothelial cell migration, negative regulation of inclusion body assembly, positive regulation of gene expression, protein refolding Taurus_UMD|evm.model.AC_000178.1.306 Q32LN7 WDR61_BOVIN 100.000 0.993464 1.00328 WDR61 - WD repeat-containing protein 61 - Bos taurus (Bovine) - WDR61 gene Cdc73/Paf1 complex, cytoplasm, nucleus, Ski complex, transcriptionally active chromatin, histone H3-K4 trimethylation, negative regulation of myeloid cell differentiation, positive regulation of histone H3-K4 methylation, positive regulation of histone H3-K79 methylation, transcription elongation from RNA polymerase II promoter Taurus_UMD|evm.model.AC_000178.1.307 P62966 RABP1_RAT 100.000 0.985507 1.0073 Crabp1 - Cellular retinoic acid-binding protein 1 - Rattus norvegicus (Rat) - Crabp1 gene Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. Taurus_UMD|evm.model.AC_000178.1.308 Q9TSV5 PO5F1_PIG 58.273 0.981982 0.308333 POU5F1 - POU domain, class 5, transcription factor 1 - Sus scrofa (Pig) - POU5F1 gene Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Taurus_UMD|evm.model.AC_000178.1.309 B3VKQ2 IREB2_PIG 85.266 0.95284 0.967842 IREB2 - Iron-responsive element-binding protein 2 - Sus scrofa (Pig) - IREB2 gene RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. Taurus_UMD|evm.model.AC_000178.1.310 A5PJU6 HYKK_BOVIN 100.000 0.994695 1.00266 HYKK - Hydroxylysine kinase - Bos taurus (Bovine) - HYKK gene Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine. Taurus_UMD|evm.model.AC_000178.1.311 P25789 PSA4_HUMAN 100.000 0.992366 1.00383 PSMA4 - Proteasome subunit alpha type-4 - Homo sapiens (Human) - PSMA4 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Taurus_UMD|evm.model.AC_000178.1.312 Q8SPU7 ACHA5_BOVIN 100.000 0.995798 1.00211 CHRNA5 - Neuronal acetylcholine receptor subunit alpha-5 precursor - Bos taurus (Bovine) - CHRNA5 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Taurus_UMD|evm.model.AC_000178.1.313 Q07263 ACHA3_BOVIN 97.951 0.925856 1.06263 CHRNA3 - Neuronal acetylcholine receptor subunit alpha-3 precursor - Bos taurus (Bovine) - CHRNA3 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Taurus_UMD|evm.model.AC_000178.1.314 Q8SPU6 ACHB4_BOVIN 98.589 0.995976 1.00202 CHRNB4 - Neuronal acetylcholine receptor subunit beta-4 precursor - Bos taurus (Bovine) - CHRNB4 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Taurus_UMD|evm.model.AC_000178.1.316 Q8WVN8 UB2Q2_HUMAN 97.354 0.994709 1.008 UBE2Q2 - Ubiquitin-conjugating enzyme E2 Q2 - Homo sapiens (Human) - UBE2Q2 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Taurus_UMD|evm.model.AC_000178.1.317 Q78JE5 FBX22_MOUSE 89.031 0.965432 1.00746 Fbxo22 - F-box only protein 22 - Mus musculus (Mouse) - Fbxo22 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Taurus_UMD|evm.model.AC_000178.1.319 Q2M3C6 TM266_HUMAN 79.406 0.995885 0.915254 TMEM266 - Transmembrane protein 266 - Homo sapiens (Human) - TMEM266 gene Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (PubMed:25165868, PubMed:30810529). Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear (PubMed:25165868, PubMed:30810529). Undergoes both rapid and slow structural rearrangements in response to changes in voltage (PubMed:30810529). Contains a zinc-binding site that can regulate the slow conformational transition (PubMed:30810529). Taurus_UMD|evm.model.AC_000178.1.320 Q2KJE4 ETFA_BOVIN 91.892 0.993789 0.966967 ETFA - Electron transfer flavoprotein subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - ETFA gene Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. Taurus_UMD|evm.model.AC_000178.1.321 Q96A47 ISL2_HUMAN 98.607 0.994444 1.00279 ISL2 - Insulin gene enhancer protein ISL-2 - Homo sapiens (Human) - ISL2 gene Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Taurus_UMD|evm.model.AC_000178.1.322 Q9BY12 SCAPE_HUMAN 91.692 0.985218 0.966429 SCAPER - S phase cyclin A-associated protein in the endoplasmic reticulum - Homo sapiens (Human) - SCAPER gene CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm. Taurus_UMD|evm.model.AC_000178.1.323 Q14257 RCN2_HUMAN 89.274 0.993711 1.00315 RCN2 - Reticulocalbin-2 precursor - Homo sapiens (Human) - RCN2 gene Not known. Binds calcium. Taurus_UMD|evm.model.AC_000178.1.324 O43586 PPIP1_HUMAN 91.106 0.995204 1.0024 PSTPIP1 - Proline-serine-threonine phosphatase-interacting protein 1 - Homo sapiens (Human) - PSTPIP1 gene Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils. Taurus_UMD|evm.model.AC_000178.1.325 Q3SZR9 TSN3_BOVIN 98.729 0.732087 1.26877 TSPAN3 - Tetraspanin-3 - Bos taurus (Bovine) - TSPAN3 gene Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair. Taurus_UMD|evm.model.AC_000178.1.326 Q9H792 PEAK1_HUMAN 90.566 0.998856 1.00115 PEAK1 - Inactive tyrosine-protein kinase PEAK1 - Homo sapiens (Human) - PEAK1 gene Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:23105102, PubMed:20534451). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). Taurus_UMD|evm.model.AC_000178.1.327 Q9NP66 HM20A_HUMAN 97.983 0.994253 1.00288 HMG20A - High mobility group protein 20A - Homo sapiens (Human) - HMG20A gene Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity). Taurus_UMD|evm.model.AC_000178.1.328 Q96FE5 LIGO1_HUMAN 99.516 0.996779 1.00161 LINGO1 - Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 precursor - Homo sapiens (Human) - LINGO1 gene Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). Taurus_UMD|evm.model.AC_000178.1.331 Q2KIH8 OD3L1_BOVIN 84.615 0.498182 1.36816 ODF3L1 - Outer dense fiber protein 3-like protein 1 - Bos taurus (Bovine) - ODF3L1 gene cytoskeleton Taurus_UMD|evm.model.AC_000178.1.332 Q6UVK1 CSPG4_HUMAN 87.037 0.999138 0.999139 CSPG4 - Chondroitin sulfate proteoglycan 4 precursor - Homo sapiens (Human) - CSPG4 gene Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. Taurus_UMD|evm.model.AC_000178.1.333 Q8WV41 SNX33_HUMAN 94.774 0.996503 0.996516 SNX33 - Sorting nexin-33 - Homo sapiens (Human) - SNX33 gene Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. Taurus_UMD|evm.model.AC_000178.1.334 Q3T0M3 IMP3_BOVIN 99.457 0.989189 1.00543 IMP3 - U3 small nucleolar ribonucleoprotein protein IMP3 - Bos taurus (Bovine) - IMP3 gene Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity). Taurus_UMD|evm.model.AC_000178.1.335 Q2TBK8 SPN1_BOVIN 100.000 0.847418 1.1768 SNUPN - Snurportin-1 - Bos taurus (Bovine) - SNUPN gene Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. Taurus_UMD|evm.model.AC_000178.1.336 P43378 PTN9_HUMAN 96.277 0.917574 1.08432 PTPN9 - Tyrosine-protein phosphatase non-receptor type 9 - Homo sapiens (Human) - PTPN9 gene Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus. Taurus_UMD|evm.model.AC_000178.1.337 Q96ST3 SIN3A_HUMAN 98.744 0.998431 1.00157 SIN3A - Paired amphipathic helix protein Sin3a - Homo sapiens (Human) - SIN3A gene Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). Taurus_UMD|evm.model.AC_000178.1.338 Q9NTJ4 MA2C1_HUMAN 92.593 0.98463 1.00096 MAN2C1 - Alpha-mannosidase 2C1 - Homo sapiens (Human) - MAN2C1 gene Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm. Taurus_UMD|evm.model.AC_000178.1.339 Q96FI4 NEIL1_HUMAN 86.410 0.994885 1.00256 NEIL1 - Endonuclease 8-like 1 - Homo sapiens (Human) - NEIL1 gene Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Taurus_UMD|evm.model.AC_000178.1.340 Q5E9V6 COMD4_BOVIN 100.000 0.891403 1.11055 COMMD4 - COMM domain-containing protein 4 - Bos taurus (Bovine) - COMMD4 gene May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Taurus_UMD|evm.model.AC_000178.1.341 P31948 STIP1_HUMAN 65.487 0.530303 0.364641 STIP1 - Stress-induced-phosphoprotein 1 - Homo sapiens (Human) - STIP1 gene Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). Taurus_UMD|evm.model.AC_000178.1.342 Q58Y74 TRCG1_MOUSE 50.296 0.8425 0.484848 Trcg1 - Taste receptor cell protein 1 precursor - Mus musculus (Mouse) - Trcg1 gene Taurus_UMD|evm.model.AC_000178.1.343 Q6ZRI6 CO039_HUMAN 73.173 0.953069 1.05826 C15orf39 - Uncharacterized protein C15orf39 - Homo sapiens (Human) - C15orf39 gene cytosol Taurus_UMD|evm.model.AC_000178.1.344 Q96CD2 COAC_HUMAN 88.384 0.848485 1.13235 PPCDC - Phosphopantothenoylcysteine decarboxylase - Homo sapiens (Human) - PPCDC gene Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine. Taurus_UMD|evm.model.AC_000178.1.345 Q17QF8 SCAM5_BOVIN 100.000 0.991525 1.00426 SCAMP5 - Secretory carrier-associated membrane protein 5 - Bos taurus (Bovine) - SCAMP5 gene Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity). Taurus_UMD|evm.model.AC_000178.1.346 Q9BUL9 RPP25_HUMAN 90.955 0.938389 1.0603 RPP25 - Ribonuclease P protein subunit p25 - Homo sapiens (Human) - RPP25 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:12003489, PubMed:16723659, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). Taurus_UMD|evm.model.AC_000178.1.347 P00426 COX5A_BOVIN 100.000 0.986928 1.00658 COX5A - Cytochrome c oxidase subunit 5A, mitochondrial precursor - Bos taurus (Bovine) - COX5A gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000178.1.348 Q5XKK7 F219B_HUMAN 86.364 0.989583 0.969697 FAM219B - Protein FAM219B - Homo sapiens (Human) - FAM219B gene Taurus_UMD|evm.model.AC_000178.1.349 Q3SZI0 MPI_BOVIN 100.000 0.518692 1.01182 MPI - Mannose-6-phosphate isomerase - Bos taurus (Bovine) - MPI gene Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. Taurus_UMD|evm.model.AC_000178.1.350 O15127 SCAM2_HUMAN 81.720 0.994624 1.1307 SCAMP2 - Secretory carrier-associated membrane protein 2 - Homo sapiens (Human) - SCAMP2 gene Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. Taurus_UMD|evm.model.AC_000178.1.351 Q6PHR2 ULK3_HUMAN 97.246 0.995772 1.00212 ULK3 - Serine/threonine-protein kinase ULK3 - Homo sapiens (Human) - ULK3 gene Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. Taurus_UMD|evm.model.AC_000178.1.352 Q0IIE0 CPLX3_BOVIN 99.367 0.987421 1.00633 CPLX3 - Complexin-3 precursor - Bos taurus (Bovine) - CPLX3 gene Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity). Taurus_UMD|evm.model.AC_000178.1.353 Q9HAT1 LMA1L_HUMAN 70.076 0.99604 0.960076 LMAN1L - Protein ERGIC-53-like precursor - Homo sapiens (Human) - LMAN1L gene collagen-containing extracellular matrix, COPII-coated ER to Golgi transport vesicle, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, Golgi membrane, mannose binding, endoplasmic reticulum organization, endoplasmic reticulum to Golgi vesicle-mediated transport, Golgi organization Taurus_UMD|evm.model.AC_000178.1.354 Q0VBZ0 CSK_BOVIN 100.000 0.995565 1.00222 CSK - Tyrosine-protein kinase CSK - Bos taurus (Bovine) - CSK gene Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity). Taurus_UMD|evm.model.AC_000178.1.355 Q3LFT9 CP1A2_BALAC 85.271 0.996132 1.00194 CYP1A2 - Cytochrome P450 1A2 - Balaenoptera acutorostrata (Common minke whale) - CYP1A2 gene A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation. Taurus_UMD|evm.model.AC_000178.1.356 P56591 CP1A1_SHEEP 93.992 0.996132 0.996146 CYP1A1 - Cytochrome P450 1A1 - Ovis aries (Sheep) - CYP1A1 gene A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions. Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation. Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer. May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Taurus_UMD|evm.model.AC_000178.1.357 Q5RDU9 EDC3_PONAB 97.441 0.996071 1.00197 EDC3 - Enhancer of mRNA-decapping protein 3 - Pongo abelii (Sumatran orangutan) - EDC3 gene Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity). Taurus_UMD|evm.model.AC_000178.1.358 Q3SX21 CLK3_BOVIN 100.000 0.953216 1.04694 CLK3 - Dual specificity protein kinase CLK3 - Bos taurus (Bovine) - CLK3 gene Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (By similarity). Taurus_UMD|evm.model.AC_000178.1.359 Q8IVW6 ARI3B_HUMAN 84.926 0.966102 0.946524 ARID3B - AT-rich interactive domain-containing protein 3B - Homo sapiens (Human) - ARID3B gene Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A. Taurus_UMD|evm.model.AC_000178.1.360 Q2KIS3 UBL7_BOVIN 87.719 0.47619 0.607895 UBL7 - Ubiquitin-like protein 7 - Bos taurus (Bovine) - UBL7 gene cytosol, polyubiquitin modification-dependent protein binding, ubiquitin-dependent protein catabolic process Taurus_UMD|evm.model.AC_000178.1.361 Q2KIS3 UBL7_BOVIN 99.737 0.938119 1.06316 UBL7 - Ubiquitin-like protein 7 - Bos taurus (Bovine) - UBL7 gene cytosol, polyubiquitin modification-dependent protein binding, ubiquitin-dependent protein catabolic process Taurus_UMD|evm.model.AC_000178.1.362 O75326 SEM7A_HUMAN 83.033 0.996992 0.998498 SEMA7A - Semaphorin-7A precursor - Homo sapiens (Human) - SEMA7A gene Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. Taurus_UMD|evm.model.AC_000178.1.364 P00189 CP11A_BOVIN 99.767 0.964045 0.855769 CYP11A1 - Cholesterol side-chain cleavage enzyme, mitochondrial precursor - Bos taurus (Bovine) - CYP11A1 gene A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (PubMed:11412116). Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (PubMed:11412116). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:11412116). Taurus_UMD|evm.model.AC_000178.1.365 Q8N5R6 CCD33_HUMAN 78.623 0.907285 0.31524 CCDC33 - Coiled-coil domain-containing protein 33 - Homo sapiens (Human) - CCDC33 gene peroxisome Taurus_UMD|evm.model.AC_000178.1.366 Q5XIR4 CCD33_RAT 79.310 0.333333 0.108387 Ccdc33 - Coiled-coil domain-containing protein 33 - Rattus norvegicus (Rat) - Ccdc33 gene peroxisome Taurus_UMD|evm.model.AC_000178.1.367 Q8N5R6 CCD33_HUMAN 75.862 0.934426 0.0636743 CCDC33 - Coiled-coil domain-containing protein 33 - Homo sapiens (Human) - CCDC33 gene peroxisome Taurus_UMD|evm.model.AC_000178.1.368 Q0V8E7 STRA6_BOVIN 99.850 0.99701 1.0015 STRA6 - Receptor for retinol uptake STRA6 - Bos taurus (Bovine) - STRA6 gene Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:17255476, PubMed:18419130). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid (By similarity). Taurus_UMD|evm.model.AC_000178.1.369 A4IFA6 ISLR_BOVIN 100.000 0.995338 1.00234 ISLR - Immunoglobulin superfamily containing leucine-rich repeat protein precursor - Bos taurus (Bovine) - ISLR gene Taurus_UMD|evm.model.AC_000178.1.370 Q6UXK2 ISLR2_HUMAN 89.867 0.963964 1.04295 ISLR2 - Immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor - Homo sapiens (Human) - ISLR2 gene Required for axon extension during neural development. Taurus_UMD|evm.model.AC_000178.1.371 P29590 PML_HUMAN 75.369 0.994266 0.988662 PML - Protein PML - Homo sapiens (Human) - PML gene Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. Taurus_UMD|evm.model.AC_000178.1.372 Q9UBI4 STML1_HUMAN 91.709 0.994987 1.00251 STOML1 - Stomatin-like protein 1 - Homo sapiens (Human) - STOML1 gene May play a role in cholesterol transfer to late endosomes (PubMed:19696025). May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation (PubMed:23082202). Taurus_UMD|evm.model.AC_000178.1.373 Q95L39 LOXL1_BOVIN 99.662 0.996627 1.00338 LOXL1 - Lysyl oxidase homolog 1 precursor - Bos taurus (Bovine) - LOXL1 gene Active on elastin and collagen substrates. Taurus_UMD|evm.model.AC_000178.1.374 P79204 MCPT2_SHEEP 87.554 0.935484 1.00813 Mast cell protease 2 precursor - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000178.1.375 P79204 MCPT2_SHEEP 89.610 0.839416 1.11382 Mast cell protease 2 precursor - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000178.1.376 P80219 DDN1_BOVIN 99.602 0.992063 1.00398 BDMD1 - Duodenase-1 precursor - Bos taurus (Bovine) - BDMD1 gene Protease which has both trypsin-like and chymotrypsin-like activities. Shows a preferential cleavage after Lys, Arg, Tyr, Phe, and Leu residues. Taurus_UMD|evm.model.AC_000178.1.377 P80219 DDN1_BOVIN 75.269 0.480418 1.5259 BDMD1 - Duodenase-1 precursor - Bos taurus (Bovine) - BDMD1 gene Protease which has both trypsin-like and chymotrypsin-like activities. Shows a preferential cleavage after Lys, Arg, Tyr, Phe, and Leu residues. Taurus_UMD|evm.model.AC_000178.1.378 P28293 CATG_MOUSE 68.122 0.904762 0.965517 Ctsg - Cathepsin G precursor - Mus musculus (Mouse) - Ctsg gene This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis. Taurus_UMD|evm.model.AC_000178.1.379 P28293 CATG_MOUSE 65.351 0.900794 0.965517 Ctsg - Cathepsin G precursor - Mus musculus (Mouse) - Ctsg gene This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis. Taurus_UMD|evm.model.AC_000178.1.380 Q63610 TPM3_RAT 85.477 0.986486 0.895161 Tpm3 - Tropomyosin alpha-3 chain - Rattus norvegicus (Rat) - Tpm3 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Taurus_UMD|evm.model.AC_000178.1.381 P20718 GRAH_HUMAN 76.371 0.940239 1.02033 GZMH - Granzyme H precursor - Homo sapiens (Human) - GZMH gene Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. Taurus_UMD|evm.model.AC_000178.1.382 P80219 DDN1_BOVIN 90.129 0.591837 1.56175 BDMD1 - Duodenase-1 precursor - Bos taurus (Bovine) - BDMD1 gene Protease which has both trypsin-like and chymotrypsin-like activities. Shows a preferential cleavage after Lys, Arg, Tyr, Phe, and Leu residues. Taurus_UMD|evm.model.AC_000178.1.383 P80219 DDN1_BOVIN 84.100 0.940711 1.00797 BDMD1 - Duodenase-1 precursor - Bos taurus (Bovine) - BDMD1 gene Protease which has both trypsin-like and chymotrypsin-like activities. Shows a preferential cleavage after Lys, Arg, Tyr, Phe, and Leu residues. Taurus_UMD|evm.model.AC_000178.1.384 O46683 MCPT3_SHEEP 56.118 0.924779 0.900398 Mast cell protease 3 precursor - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000178.1.385 P10144 GRAB_HUMAN 72.653 0.983806 1 GZMB - Granzyme B precursor - Homo sapiens (Human) - GZMB gene Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3262682, PubMed:3263427, PubMed:1985927). It cleaves after Asp (PubMed:8258716, PubMed:1985927). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (PubMed:32188940, PubMed:31953257). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (PubMed:9852092). Taurus_UMD|evm.model.AC_000178.1.386 Q8R3T5 STXB6_MOUSE 99.524 0.990521 1.00476 Stxbp6 - Syntaxin-binding protein 6 - Mus musculus (Mouse) - Stxbp6 gene Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis. Taurus_UMD|evm.model.AC_000178.1.388 P46791 RS2_CRIGR 44.755 0.851562 0.633663 RPS2 - 40S ribosomal protein S2 - Cricetulus griseus (Chinese hamster) - RPS2 gene Taurus_UMD|evm.model.AC_000178.1.391 P51513 NOVA1_HUMAN 99.803 0.996063 1.00197 NOVA1 - RNA-binding protein Nova-1 - Homo sapiens (Human) - NOVA1 gene May regulate RNA splicing or metabolism in a specific subset of developing neurons. Taurus_UMD|evm.model.AC_000178.1.393 P02552 TBA1_CHICK 73.418 0.820312 0.621359 Tubulin alpha-1 chain - Gallus gallus (Chicken) Taurus_UMD|evm.model.AC_000178.1.395 Q1A1A2 FOXG1_EQUBU 99.506 0.821138 1.0082 FOXG1 - Forkhead box protein G1 - Equus burchelli (Plains zebra) - FOXG1 gene Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. Taurus_UMD|evm.model.AC_000178.1.396 Q15139 KPCD1_HUMAN 92.709 0.940189 1.04496 PRKD1 - Serine/threonine-protein kinase D1 - Homo sapiens (Human) - PRKD1 gene Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling. Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor. Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). Taurus_UMD|evm.model.AC_000178.1.397 Q5R4D4 NP1L1_PONAB 69.811 0.963415 0.209719 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Pongo abelii (Sumatran orangutan) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Taurus_UMD|evm.model.AC_000178.1.398 A6H767 NP1L1_BOVIN 92.265 0.98895 0.462916 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Bos taurus (Bovine) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Taurus_UMD|evm.model.AC_000178.1.399 Q7L622 G2E3_HUMAN 86.648 0.962963 1.03258 G2E3 - G2/M phase-specific E3 ubiquitin-protein ligase - Homo sapiens (Human) - G2E3 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death. Taurus_UMD|evm.model.AC_000178.1.400 Q8WVM8 SCFD1_HUMAN 97.966 0.993769 1 SCFD1 - Sec1 family domain-containing protein 1 - Homo sapiens (Human) - SCFD1 gene Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). Taurus_UMD|evm.model.AC_000178.1.402 Q5EA64 COCH_BOVIN 99.818 0.99637 1.00182 COCH - Cochlin precursor - Bos taurus (Bovine) - COCH gene Plays a role in the control of cell shape and motility in the trabecular meshwork. Taurus_UMD|evm.model.AC_000178.1.403 A5D7H2 STRN3_BOVIN 100.000 0.997494 1.00125 STRN3 - Striatin-3 - Bos taurus (Bovine) - STRN3 gene Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (By similarity). Taurus_UMD|evm.model.AC_000178.1.404 Q3ZBB6 AP4S1_BOVIN 100.000 0.986207 1.00694 AP4S1 - AP-4 complex subunit sigma-1 - Bos taurus (Bovine) - AP4S1 gene Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal. Taurus_UMD|evm.model.AC_000178.1.405 Q9ULT8 HECD1_HUMAN 99.617 0.999234 1.00038 HECTD1 - E3 ubiquitin-protein ligase HECTD1 - Homo sapiens (Human) - HECTD1 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure. Taurus_UMD|evm.model.AC_000178.1.406 Q86XA9 HTR5A_HUMAN 92.424 0.999022 1.00294 HEATR5A - HEAT repeat-containing protein 5A - Homo sapiens (Human) - HEATR5A gene endocytic vesicle, endocytosis, protein localization, retrograde transport, endosome to Golgi Taurus_UMD|evm.model.AC_000178.1.407 Q96FN9 DTD2_HUMAN 89.286 0.988166 1.00595 DTD2 - D-aminoacyl-tRNA deacylase 2 - Homo sapiens (Human) - DTD2 gene Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408). Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408). Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity). Taurus_UMD|evm.model.AC_000178.1.408 Q49SQ3 GPR33_PANTR 78.733 0.956522 0.690691 GPR33 - Probable G-protein coupled receptor 33 - Pan troglodytes (Chimpanzee) - GPR33 gene Orphan receptor; could be a chemoattractant receptor. Taurus_UMD|evm.model.AC_000178.1.409 Q8TB37 NUBPL_HUMAN 90.596 0.880886 1.13166 NUBPL - Iron-sulfur protein NUBPL precursor - Homo sapiens (Human) - NUBPL gene Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits. Taurus_UMD|evm.model.AC_000178.1.410 Q13017 RHG05_HUMAN 99.010 0.473508 0.992676 ARHGAP5 - Rho GTPase-activating protein 5 - Homo sapiens (Human) - ARHGAP5 gene GTPase-activating protein for Rho family members (PubMed:8537347). Taurus_UMD|evm.model.AC_000178.1.412 Q13023 AKAP6_HUMAN 86.908 0.999138 1.00043 AKAP6 - A-kinase anchor protein 6 - Homo sapiens (Human) - AKAP6 gene Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. Taurus_UMD|evm.model.AC_000178.1.413 Q8IXF0 NPAS3_HUMAN 94.588 0.997509 0.860665 NPAS3 - Neuronal PAS domain-containing protein 3 - Homo sapiens (Human) - NPAS3 gene May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity). Taurus_UMD|evm.model.AC_000178.1.414 Q9H6Z9 EGLN3_HUMAN 80.753 0.99 0.83682 EGLN3 - Prolyl hydroxylase EGLN3 - Homo sapiens (Human) - EGLN3 gene Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as PKM, TELO2, ATF4 and HIF1A (PubMed:19584355, PubMed:21620138, PubMed:21483450, PubMed:22797300, PubMed:20978507, PubMed:21575608). Target proteins are preferentially recognized via a LXXLAP motif. Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12181324). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12181324). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12181324). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12181324). Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site (PubMed:11595184, PubMed:12181324). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12181324). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12181324). ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limiting glycolysis (PubMed:21620138, PubMed:21483450). Under normoxia, hydroxylates and regulates the stability of ADRB2 (PubMed:19584355). Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex (PubMed:20849813). In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity (PubMed:16098468). Also essential for hypoxic regulation of neutrophilic inflammation (PubMed:21317538). Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway (PubMed:22797300). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (Probable). Taurus_UMD|evm.model.AC_000178.1.415 Q2TBQ5 RL7A_BOVIN 79.681 0.930328 0.917293 RPL7A - 60S ribosomal protein L7a - Bos taurus (Bovine) - RPL7A gene cytosolic large ribosomal subunit, RNA binding, maturation of LSU-rRNA Taurus_UMD|evm.model.AC_000178.1.416 P62752 RL23A_RAT 87.879 0.882883 0.711538 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000178.1.417 Q56P03 EAPP_HUMAN 90.909 0.965986 1.03158 EAPP - E2F-associated phosphoprotein - Homo sapiens (Human) - EAPP gene May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. Taurus_UMD|evm.model.AC_000178.1.418 P10301 RRAS_HUMAN 94.872 0.324786 0.536697 RRAS - Ras-related protein R-Ras precursor - Homo sapiens (Human) - RRAS gene Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267). Taurus_UMD|evm.model.AC_000178.1.419 Q5R613 SNX6_PONAB 99.742 0.98977 0.963054 SNX6 - Sorting nexin-6 - Pongo abelii (Sumatran orangutan) - SNX6 gene Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation. In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B. May contribute to transcription regulation (By similarity). Taurus_UMD|evm.model.AC_000178.1.420 Q5RAI8 CPSF5_PONAB 87.356 0.664062 0.563877 NUDT21 - Cleavage and polyadenylation specificity factor subunit 5 - Pongo abelii (Sumatran orangutan) - NUDT21 gene Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7. Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function. Binds to chromatin. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. Taurus_UMD|evm.model.AC_000178.1.421 Q5G6V9 COF2_PIG 100.000 0.988024 1.00602 CFL2 - Cofilin-2 - Sus scrofa (Pig) - CFL2 gene Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). Taurus_UMD|evm.model.AC_000178.1.422 Q9NRL2 BAZ1A_HUMAN 93.553 0.997203 0.919023 BAZ1A - Bromodomain adjacent to zinc finger domain protein 1A - Homo sapiens (Human) - BAZ1A gene Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression. Taurus_UMD|evm.model.AC_000178.1.423 Q9NRL2 BAZ1A_HUMAN 96.947 0.984848 0.0848329 BAZ1A - Bromodomain adjacent to zinc finger domain protein 1A - Homo sapiens (Human) - BAZ1A gene Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression. Taurus_UMD|evm.model.AC_000178.1.425 Q5R4R6 SRP54_PONAB 100.000 0.99604 1.00198 SRP54 - Signal recognition particle 54 kDa protein - Pongo abelii (Sumatran orangutan) - SRP54 gene Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development. Taurus_UMD|evm.model.AC_000178.1.426 P24049 RL17_RAT 89.674 0.988701 0.961957 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000178.1.427 A6QLZ5 F177A_BOVIN 100.000 0.894068 1.11321 FAM177A1 - Protein FAM177A1 - Bos taurus (Bovine) - FAM177A1 gene Taurus_UMD|evm.model.AC_000178.1.428 Q5E9G1 P2R3C_BOVIN 100.000 0.995595 1.00221 PPP2R3C - Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma - Bos taurus (Bovine) - PPP2R3C gene May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells. Taurus_UMD|evm.model.AC_000178.1.429 Q4R366 MRPP3_MACFA 80.137 0.996581 1.00688 PRORP - Mitochondrial ribonuclease P catalytic subunit precursor - Macaca fascicularis (Crab-eating macaque) - PRORP gene Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends. Taurus_UMD|evm.model.AC_000178.1.430 P60901 PSA6_RAT 100.000 0.933673 0.796748 Psma6 - Proteasome subunit alpha type-6 - Rattus norvegicus (Rat) - Psma6 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Taurus_UMD|evm.model.AC_000178.1.432 Q08353 IKBA_PIG 99.363 0.993651 1.00318 NFKBIA - NF-kappa-B inhibitor alpha - Sus scrofa (Pig) - NFKBIA gene Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. Taurus_UMD|evm.model.AC_000178.1.433 Q96T92 INSM2_HUMAN 83.426 0.99053 0.932862 INSM2 - Insulinoma-associated protein 2 - Homo sapiens (Human) - INSM2 gene May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons. Taurus_UMD|evm.model.AC_000178.1.434 P86409 RGPA1_PIG 99.703 0.12973 7.68546 RALGAPA1 - Ral GTPase-activating protein subunit alpha-1 - Sus scrofa (Pig) - RALGAPA1 gene Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. Taurus_UMD|evm.model.AC_000178.1.435 Q5PSV4 BRM1L_HUMAN 93.064 0.994236 1.0743 BRMS1L - Breast cancer metastasis-suppressor 1-like protein - Homo sapiens (Human) - BRMS1L gene Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth. Taurus_UMD|evm.model.AC_000178.1.436 Q9NS73 MBIP1_HUMAN 89.535 0.994203 1.00291 MBIP - MAP3K12-binding inhibitory protein 1 - Homo sapiens (Human) - MBIP gene Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Taurus_UMD|evm.model.AC_000178.1.437 P19133 FRIL_PIG 67.949 0.506667 1.92308 FTL - Ferritin light chain - Sus scrofa (Pig) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000178.1.438 P43698 TITF1_CANLF 97.849 0.994609 1 TITF1 - Thyroid transcription factor 1 - Canis lupus familiaris (Dog) - TITF1 gene Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Taurus_UMD|evm.model.AC_000178.1.439 O15522 NKX28_HUMAN 87.029 0.8 1.23431 NKX2-8 - Homeobox protein Nkx-2.8 - Homo sapiens (Human) - NKX2-8 gene chromatin, nucleus, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, double-stranded DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, cell differentiation Taurus_UMD|evm.model.AC_000178.1.440 Q9GZP4 PITH1_HUMAN 74.026 0.95 0.379147 PITHD1 - PITH domain-containing protein 1 - Homo sapiens (Human) - PITHD1 gene Promotes megakaryocyte differentiation by up-regulating RUNX1 expression (PubMed:25134913). Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry site (IRES) element in the RUNX1 gene (PubMed:25134913). Taurus_UMD|evm.model.AC_000178.1.441 Q2VL51 PAX9_LEPED 98.830 0.994169 1.00587 PAX9 - Paired box protein Pax-9 - Lepilemur edwardsi (Milne-Edwards's sportive lemur) - PAX9 gene Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. Taurus_UMD|evm.model.AC_000178.1.442 A0JN87 ODC_BOVIN 99.167 0.901887 0.886288 SLC25A21 - Mitochondrial 2-oxodicarboxylate carrier - Bos taurus (Bovine) - SLC25A21 gene Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate. Taurus_UMD|evm.model.AC_000178.1.444 Q8TD10 MIPO1_HUMAN 83.032 0.995381 0.979638 MIPOL1 - Mirror-image polydactyly gene 1 protein - Homo sapiens (Human) - MIPOL1 gene nucleus, identical protein binding Taurus_UMD|evm.model.AC_000178.1.445 P35582 FOXA1_MOUSE 93.817 0.995736 1.00214 Foxa1 - Hepatocyte nuclear factor 3-alpha - Mus musculus (Mouse) - Foxa1 gene Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas, lungs and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles. Plays a role in prostate morphogenesis and epithelial cell differentiation. FOXA1 and FOXA2 are essential for hepatic specification. FOXA1 and FOXA2 are required for morphogenesis and cell differentiation during formation of the lung. FOXA1 and FOXA2 are involved in bile duct formation; they positively regulate the binding of glucocorticoid receptor/NR3C1 to the IL6 promoter. FOXA1 and FOXA2 regulate multiple phases of midbrain dopaminergic neuron development; they regulate expression of NEUROG2 at the beginning of mDA neurogenesis and of NR4A2 and EN1 in immature mDA neurons. Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription. Inhibits NKX2-1-mediated transcription from the SFTPC promoter in lung epithel independently from DNA-binding. Involved in regulation of apoptosis. Involved in cell cycle regulation. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; activates the GCG promoter. Taurus_UMD|evm.model.AC_000178.1.446 Q86TZ1 TTC6_HUMAN 84.500 0.211783 3.62308 TTC6 - Tetratricopeptide repeat protein 6 - Homo sapiens (Human) - TTC6 gene Taurus_UMD|evm.model.AC_000178.1.448 P30872 SSR1_HUMAN 99.744 0.994885 1 SSTR1 - Somatostatin receptor type 1 - Homo sapiens (Human) - SSTR1 gene Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. Taurus_UMD|evm.model.AC_000178.1.449 Q86T13 CLC14_HUMAN 74.082 0.99389 1.00204 CLEC14A - C-type lectin domain family 14 member A precursor - Homo sapiens (Human) - CLEC14A gene collagen-containing extracellular matrix, external side of plasma membrane, extracellular matrix binding, extracellular matrix protein binding, cell migration, vascular endothelial growth factor receptor-2 signaling pathway, vascular endothelial growth factor receptor-3 signaling pathway Taurus_UMD|evm.model.AC_000178.1.450 A2VDL8 SC23A_BOVIN 100.000 0.988251 0.997396 SEC23A - Protein transport protein Sec23A - Bos taurus (Bovine) - SEC23A gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane. Taurus_UMD|evm.model.AC_000178.1.451 O14893 GEMI2_HUMAN 93.929 0.992883 1.00357 GEMIN2 - Gem-associated protein 2 - Homo sapiens (Human) - GEMIN2 gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Taurus_UMD|evm.model.AC_000178.1.452 Q86SZ2 TPC6B_HUMAN 100.000 0.987421 1.00633 TRAPPC6B - Trafficking protein particle complex subunit 6B - Homo sapiens (Human) - TRAPPC6B gene Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (PubMed:16025134, PubMed:16828797). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable). Taurus_UMD|evm.model.AC_000178.1.453 Q5R5X0 PININ_PONAB 93.075 0.99723 1.00417 PNN - Pinin - Pongo abelii (Sumatran orangutan) - PNN gene Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion (By similarity). Taurus_UMD|evm.model.AC_000178.1.454 Q96PC5 MIA2_HUMAN 71.519 0.979751 0.454674 MIA2 - Melanoma inhibitory activity protein 2 precursor - Homo sapiens (Human) - MIA2 gene Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:27138255, PubMed:21525241, PubMed:25202031, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). Taurus_UMD|evm.model.AC_000178.1.455 Q96PC5 MIA2_HUMAN 86.445 0.970075 0.567989 MIA2 - Melanoma inhibitory activity protein 2 precursor - Homo sapiens (Human) - MIA2 gene Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:27138255, PubMed:21525241, PubMed:25202031, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). Taurus_UMD|evm.model.AC_000178.1.456 Q7Z6M2 FBX33_HUMAN 89.464 0.996183 0.944144 FBXO33 - F-box only protein 33 - Homo sapiens (Human) - FBXO33 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity). Taurus_UMD|evm.model.AC_000178.1.457 P27117 DCOR_BOVIN 74.400 0.473684 0.535792 ODC1 - Ornithine decarboxylase - Bos taurus (Bovine) - ODC1 gene Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Taurus_UMD|evm.model.AC_000178.1.458 Q13309 SKP2_HUMAN 80.488 0.473684 0.403302 SKP2 - S-phase kinase-associated protein 2 - Homo sapiens (Human) - SKP2 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:17962192, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Taurus_UMD|evm.model.AC_000178.1.460 P61291 PSME3_PIG 49.162 0.991935 0.488189 PSME3 - Proteasome activator complex subunit 3 - Sus scrofa (Pig) - PSME3 gene Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (By similarity). Taurus_UMD|evm.model.AC_000178.1.461 P61291 PSME3_PIG 74.000 0.960784 0.200787 PSME3 - Proteasome activator complex subunit 3 - Sus scrofa (Pig) - PSME3 gene Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (By similarity). Taurus_UMD|evm.model.AC_000178.1.462 Q96NI6 LRFN5_HUMAN 96.662 0.997214 0.998609 LRFN5 - Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor - Homo sapiens (Human) - LRFN5 gene Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons. Taurus_UMD|evm.model.AC_000178.1.463 Q6UVY6 MOXD1_HUMAN 84.091 0.934021 0.791191 MOXD1 - DBH-like monooxygenase protein 1 precursor - Homo sapiens (Human) - MOXD1 gene endoplasmic reticulum membrane, extracellular space, secretory granule membrane, copper ion binding, dopamine beta-monooxygenase activity, dopamine catabolic process, norepinephrine biosynthetic process, octopamine biosynthetic process Taurus_UMD|evm.model.AC_000178.1.464 O75928 PIAS2_HUMAN 82.213 0.897638 0.409018 PIAS2 - E3 SUMO-protein ligase PIAS2 - Homo sapiens (Human) - PIAS2 gene Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'. Taurus_UMD|evm.model.AC_000178.1.465 Q8C5D8 PIAS2_MOUSE 87.500 0.654206 0.172303 Pias2 - E3 SUMO-protein ligase PIAS2 - Mus musculus (Mouse) - Pias2 gene Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIASx-beta, but not isoform PIASx-alpha, promotes MDM2 sumoylation. Isoform PIASx-alpha promotes PARK7 sumoylation. Isoform PIASx-beta promotes NCOA2 sumoylation more efficiently than isoform PIASx-alpha (By similarity). Sumoylates PML at'Lys-65' and 'Lys-160' (By similarity). Taurus_UMD|evm.model.AC_000178.1.466 Q5TC63 GRTP1_HUMAN 49.749 0.944444 0.589286 GRTP1 - Growth hormone-regulated TBC protein 1 - Homo sapiens (Human) - GRTP1 gene May act as a GTPase-activating protein for Rab family protein(s). Taurus_UMD|evm.model.AC_000178.1.467 P63170 DYL1_RAT 98.876 0.977778 1.01124 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Taurus_UMD|evm.model.AC_000178.1.468 Q2T9N0 FSCB_BOVIN 99.878 0.997558 1.00122 FSCB - Fibrous sheath CABYR-binding protein - Bos taurus (Bovine) - FSCB gene May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium. Taurus_UMD|evm.model.AC_000178.1.469 A4FUH0 RL22L_BOVIN 80.328 0.72 1.22951 RPL22L1 - 60S ribosomal protein L22-like 1 - Bos taurus (Bovine) - RPL22L1 gene RNA binding, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000178.1.471 Q4W4Y0 CN028_HUMAN 98.065 0.993569 1.00323 C14orf28 - Uncharacterized protein C14orf28 - Homo sapiens (Human) - C14orf28 gene Taurus_UMD|evm.model.AC_000178.1.472 Q9NXS3 KLH28_HUMAN 99.124 0.996503 1.00175 KLHL28 - Kelch-like protein 28 - Homo sapiens (Human) - KLHL28 gene Taurus_UMD|evm.model.AC_000178.1.473 P79103 RS4_BOVIN 81.928 0.88172 0.707224 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000178.1.475 Q9Y4F4 TGRM1_HUMAN 84.126 0.990104 1.05756 TOGARAM1 - TOG array regulator of axonemal microtubules protein 1 - Homo sapiens (Human) - TOGARAM1 gene Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity). Taurus_UMD|evm.model.AC_000178.1.476 Q86UA1 PRP39_HUMAN 95.516 0.997006 0.998505 PRPF39 - Pre-mRNA-processing factor 39 - Homo sapiens (Human) - PRPF39 gene Involved in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000178.1.477 P26884 FKBP3_BOVIN 100.000 0.906504 1.09821 FKBP3 - Peptidyl-prolyl cis-trans isomerase FKBP3 - Bos taurus (Bovine) - FKBP3 gene FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two dinstinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. Taurus_UMD|evm.model.AC_000178.1.478 Q8IYD8 FANCM_HUMAN 74.527 0.99852 0.989746 FANCM - Fanconi anemia group M protein - Homo sapiens (Human) - FANCM gene DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). Taurus_UMD|evm.model.AC_000178.1.479 Q6P0N0 M18BP_HUMAN 74.107 0.248009 0.776502 MIS18BP1 - Mis18-binding protein 1 - Homo sapiens (Human) - MIS18BP1 gene Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. Taurus_UMD|evm.model.AC_000178.1.480 Q32KN9 PRLD1_BOVIN 95.238 0.54386 0.520548 PRELID1 - PRELI domain-containing protein 1, mitochondrial precursor - Bos taurus (Bovine) - PRELID1 gene Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs (By similarity). Taurus_UMD|evm.model.AC_000178.1.481 O43548 TGM5_HUMAN 85.615 0.994413 0.994444 TGM5 - Protein-glutamine gamma-glutamyltransferase 5 - Homo sapiens (Human) - TGM5 gene Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes. Taurus_UMD|evm.model.AC_000178.1.482 Q96PF1 TGM7_HUMAN 82.320 0.950202 1.04648 TGM7 - Protein-glutamine gamma-glutamyltransferase Z - Homo sapiens (Human) - TGM7 gene Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Taurus_UMD|evm.model.AC_000178.1.483 O60294 TYW4_HUMAN 81.633 0.997085 1 LCMT2 - tRNA wybutosine-synthesizing protein 4 - Homo sapiens (Human) - LCMT2 gene Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues. Taurus_UMD|evm.model.AC_000178.1.484 P24049 RL17_RAT 100.000 0.989189 1.00543 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000178.1.485 Q0VC13 ADAL_BOVIN 99.715 0.994318 1.00285 ADAL - Adenosine deaminase-like protein - Bos taurus (Bovine) - ADAL gene Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A). Taurus_UMD|evm.model.AC_000178.1.486 Q8IWY8 ZSC29_HUMAN 87.222 0.997647 0.997653 ZSCAN29 - Zinc finger and SCAN domain-containing protein 29 - Homo sapiens (Human) - ZSCAN29 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000178.1.487 Q9UGJ1 GCP4_HUMAN 98.801 0.997001 1 TUBGCP4 - Gamma-tubulin complex component 4 - Homo sapiens (Human) - TUBGCP4 gene Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Taurus_UMD|evm.model.AC_000178.1.488 Q12888 TP53B_HUMAN 87.278 0.996441 0.997465 TP53BP1 - TP53-binding protein 1 - Homo sapiens (Human) - TP53BP1 gene Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). Taurus_UMD|evm.model.AC_000178.1.489 P14401 ENP2_TETCF 80.240 0.106628 8.92286 Electromotor neuron-associated protein 2 - Tetronarce californica (Pacific electric ray) Taurus_UMD|evm.model.AC_000178.1.490 A7Z050 VIP1_BOVIN 100.000 0.998647 1.00068 PPIP5K1 - Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 - Bos taurus (Bovine) - PPIP5K1 gene Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. Taurus_UMD|evm.model.AC_000178.1.491 Q9TTK8 KCRU_BOVIN 100.000 0.995204 1.0024 CKMT1 - Creatine kinase U-type, mitochondrial precursor - Bos taurus (Bovine) - CKMT1 gene Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). Taurus_UMD|evm.model.AC_000178.1.492 Q7RTU9 STRC_HUMAN 90.479 0.998867 0.994366 STRC - Stereocilin precursor - Homo sapiens (Human) - STRC gene Essential to the formation of horizontal top connectors between outer hair cell stereocilia. Taurus_UMD|evm.model.AC_000178.1.493 A2ARP9 CTSR2_MOUSE 80.109 0.653571 0.952381 Catsper2 - Cation channel sperm-associated protein 2 - Mus musculus (Mouse) - Catsper2 gene Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. Taurus_UMD|evm.model.AC_000178.1.494 P38657 PDIA3_BOVIN 99.605 0.996055 1.00396 PDIA3 - Protein disulfide-isomerase A3 precursor - Bos taurus (Bovine) - PDIA3 gene endoplasmic reticulum, positive regulation of apoptotic process Taurus_UMD|evm.model.AC_000178.1.495 F1MGG3 ELL3_BOVIN 100.000 0.994949 1.00253 ELL3 - RNA polymerase II elongation factor ELL3 - Bos taurus (Bovine) - ELL3 gene Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Taurus_UMD|evm.model.AC_000178.1.496 Q5R7C4 SERF2_PONAB 94.915 0.865672 1.13559 SERF2 - Small EDRK-rich factor 2 - Pongo abelii (Sumatran orangutan) - SERF2 gene Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity). Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates (By similarity). Taurus_UMD|evm.model.AC_000178.1.497 A6NH21 SERC4_HUMAN 84.884 0.994197 0.998069 SERINC4 - Serine incorporator 4 - Homo sapiens (Human) - SERINC4 gene Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids. Taurus_UMD|evm.model.AC_000178.1.498 Q9CR41 HYPK_MOUSE 100.000 0.983607 0.945736 Hypk - Huntingtin-interacting protein K - Mus musculus (Mouse) - Hypk gene Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in neuronal cells (By similarity). Regulator of the N-terminal acetyltransferase NAA10-NAA15 complex (By similarity). Has been in one study shown to be required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity). However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity). Taurus_UMD|evm.model.AC_000178.1.499 Q5EA98 MFAP1_BOVIN 100.000 0.995455 1.00228 MFAP1 - Microfibrillar-associated protein 1 - Bos taurus (Bovine) - MFAP1 gene Involved in pre-mRNA splicing as a component of the spliceosome. Taurus_UMD|evm.model.AC_000178.1.500 B2KIQ4 WDR76_RHIFE 80.635 0.996815 0.996825 WDR76 - WD repeat-containing protein 76 - Rhinolophus ferrumequinum (Greater horseshoe bat) - WDR76 gene Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Taurus_UMD|evm.model.AC_000178.1.501 Q7Z6J6 FRMD5_HUMAN 98.246 0.996497 1.00175 FRMD5 - FERM domain-containing protein 5 - Homo sapiens (Human) - FRMD5 gene May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675). Taurus_UMD|evm.model.AC_000178.1.502 Q5ZKQ5 GOLM2_CHICK 56.140 0.321839 0.464 GOLM2 - Protein GOLM2 - Gallus gallus (Chicken) - GOLM2 gene Taurus_UMD|evm.model.AC_000178.1.503 Q7Z3D6 GLUCM_HUMAN 53.704 0.407895 0.37013 DGLUCY - D-glutamate cyclase, mitochondrial precursor - Homo sapiens (Human) - DGLUCY gene D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline. Taurus_UMD|evm.model.AC_000178.1.504 O46685 OGR1_BOVIN 100.000 0.994475 1.00277 GPR68 - Ovarian cancer G-protein coupled receptor 1 - Bos taurus (Bovine) - GPR68 gene Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (By similarity). Also functions as a metastasis suppressor gene in prostate cancer (By similarity). Taurus_UMD|evm.model.AC_000178.1.505 Q9P219 DAPLE_HUMAN 84.079 0.999014 1.00049 CCDC88C - Protein Daple - Homo sapiens (Human) - CCDC88C gene Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). Taurus_UMD|evm.model.AC_000178.1.506 Q6P2K6 P4R3A_MOUSE 98.780 0.997564 1.00122 Ppp4r3a - Serine/threonine-protein phosphatase 4 regulatory subunit 3A - Mus musculus (Mouse) - Ppp4r3a gene Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair (By similarity). Taurus_UMD|evm.model.AC_000178.1.508 Q3T0Q8 UT14A_BOVIN 94.156 0.997406 1.0013 UTP14A - U3 small nucleolar RNA-associated protein 14 homolog A - Bos taurus (Bovine) - UTP14A gene May be required for ribosome biogenesis. Taurus_UMD|evm.model.AC_000178.1.509 Q9H7T0 CTSRB_HUMAN 71.676 0.934144 0.884409 CATSPERB - Cation channel sperm-associated protein subunit beta - Homo sapiens (Human) - CATSPERB gene Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Taurus_UMD|evm.model.AC_000178.1.510 Q8N9U0 TAC2N_HUMAN 91.020 0.995927 1.00204 TC2N - Tandem C2 domains nuclear protein - Homo sapiens (Human) - TC2N gene nucleus Taurus_UMD|evm.model.AC_000178.1.511 Q5EA62 FBLN5_BOVIN 99.777 0.995546 1.00223 FBLN5 - Fibulin-5 precursor - Bos taurus (Bovine) - FBLN5 gene Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. Taurus_UMD|evm.model.AC_000178.1.512 Q15643 TRIPB_HUMAN 84.690 0.98978 0.988883 TRIP11 - Thyroid receptor-interacting protein 11 - Homo sapiens (Human) - TRIP11 gene Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Taurus_UMD|evm.model.AC_000178.1.513 Q3SZ63 NOP56_BOVIN 97.159 0.988701 0.29698 NOP56 - Nucleolar protein 56 - Bos taurus (Bovine) - NOP56 gene Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). Taurus_UMD|evm.model.AC_000178.1.514 P54252 ATX3_HUMAN 88.669 0.937158 1.01385 ATXN3 - Ataxin-3 - Homo sapiens (Human) - ATXN3 gene Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). Taurus_UMD|evm.model.AC_000178.1.515 Q10568 CPSF2_BOVIN 100.000 0.997446 1.00128 CPSF2 - Cleavage and polyadenylation specificity factor subunit 2 - Bos taurus (Bovine) - CPSF2 gene Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing (By similarity). Taurus_UMD|evm.model.AC_000178.1.516 Q8NFF2 NCKX4_HUMAN 86.364 0.425743 0.162379 SLC24A4 - Sodium/potassium/calcium exchanger 4 precursor - Homo sapiens (Human) - SLC24A4 gene Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity). Taurus_UMD|evm.model.AC_000178.1.517 Q8NFF2 NCKX4_HUMAN 92.435 0.976534 0.890675 SLC24A4 - Sodium/potassium/calcium exchanger 4 precursor - Homo sapiens (Human) - SLC24A4 gene Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity). Taurus_UMD|evm.model.AC_000178.1.518 Q8TB24 RIN3_HUMAN 72.315 0.997961 0.995939 RIN3 - Ras and Rab interactor 3 - Homo sapiens (Human) - RIN3 gene Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function. Taurus_UMD|evm.model.AC_000178.1.519 Q95M12 LGMN_BOVIN 99.769 0.995392 1.00231 LGMN - Legumain precursor - Bos taurus (Bovine) - LGMN gene Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). Required for normal lysosomal protein degradation in renal proximal tubules. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Taurus_UMD|evm.model.AC_000178.1.520 Q8TBA6 GOGA5_HUMAN 89.208 0.997271 1.00274 GOLGA5 - Golgin subfamily A member 5 - Homo sapiens (Human) - GOLGA5 gene Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. Taurus_UMD|evm.model.AC_000178.1.521 P05059 CMGA_BOVIN 99.555 0.995556 1.00223 CHGA - Chromogranin-A precursor - Bos taurus (Bovine) - CHGA gene Strongly inhibits glucose induced insulin release from the pancreas. Taurus_UMD|evm.model.AC_000178.1.522 P0C0T1 ITPK1_BOVIN 100.000 0.995238 1.00239 ITPK1 - Inositol-tetrakisphosphate 1-kinase - Bos taurus (Bovine) - ITPK1 gene Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (By similarity). Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (By similarity). Taurus_UMD|evm.model.AC_000178.1.524 P0C8B3 GON7_BOVIN 100.000 0.980198 1.01 GON7 - EKC/KEOPS complex subunit GON7 - Bos taurus (Bovine) - GON7 gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex. Taurus_UMD|evm.model.AC_000178.1.525 Q8N806 UBR7_HUMAN 90.824 0.995305 1.00235 UBR7 - Putative E3 ubiquitin-protein ligase UBR7 - Homo sapiens (Human) - UBR7 gene E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Taurus_UMD|evm.model.AC_000178.1.526 Q9P203 BTBD7_HUMAN 95.671 0.998224 0.9947 BTBD7 - BTB/POZ domain-containing protein 7 - Homo sapiens (Human) - BTBD7 gene Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). Taurus_UMD|evm.model.AC_000178.1.527 Q7Z4L0 COX8C_HUMAN 62.069 0.504425 1.56944 COX8C - Cytochrome c oxidase subunit 8C, mitochondrial precursor - Homo sapiens (Human) - COX8C gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000178.1.529 Q9P2D8 UNC79_HUMAN 87.884 0.996915 0.984061 UNC79 - Protein unc-79 homolog - Homo sapiens (Human) - UNC79 gene Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability. Taurus_UMD|evm.model.AC_000178.1.530 Q86XR5 PRIMA_HUMAN 92.157 0.873563 1.13725 PRIMA1 - Proline-rich membrane anchor 1 precursor - Homo sapiens (Human) - PRIMA1 gene Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers (By similarity). Taurus_UMD|evm.model.AC_000178.1.531 Q8N9Y4 F181A_HUMAN 85.324 0.993197 0.830508 FAM181A - Protein FAM181A - Homo sapiens (Human) - FAM181A gene Taurus_UMD|evm.model.AC_000178.1.532 Q3SX45 ASB2_BOVIN 99.842 0.996845 1.00158 ASB2 - Ankyrin repeat and SOCS box protein 2 - Bos taurus (Bovine) - ASB2 gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000178.1.533 Q8NCU1 CC197_HUMAN 71.901 0.392157 2.13986 CCDC197 - Uncharacterized protein CCDC197 - Homo sapiens (Human) - CCDC197 gene Taurus_UMD|evm.model.AC_000178.1.534 Q9CQX0 OTUB2_MOUSE 96.137 0.659091 1.50427 Otub2 - Ubiquitin thioesterase OTUB2 - Mus musculus (Mouse) - Otub2 gene Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains (By similarity). Taurus_UMD|evm.model.AC_000178.1.535 Q9GZR7 DDX24_HUMAN 81.034 0.997655 0.993015 DDX24 - ATP-dependent RNA helicase DDX24 - Homo sapiens (Human) - DDX24 gene ATP-dependent RNA helicase. Taurus_UMD|evm.model.AC_000178.1.536 Q8R412 IF27A_MOUSE 80.597 0.305556 2.4 Ifi27l2a - Interferon alpha-inducible protein 27-like protein 2A precursor - Mus musculus (Mouse) - Ifi27l2a gene May be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). Through the regulation of NR4A1 transcriptional activity, may play a role in the vascular response to injury (PubMed:22427340). Taurus_UMD|evm.model.AC_000178.1.537 Q24JY7 I27L2_BOVIN 75.000 0.166197 2.66917 IFI27L2 - Interferon alpha-inducible protein 27-like protein 2 - Bos taurus (Bovine) - IFI27L2 gene Plays a role in the apoptotic process and has a pro-apoptotic activity. Taurus_UMD|evm.model.AC_000178.1.538 Q24JY7 I27L2_BOVIN 100.000 0.985075 1.00752 IFI27L2 - Interferon alpha-inducible protein 27-like protein 2 - Bos taurus (Bovine) - IFI27L2 gene Plays a role in the apoptotic process and has a pro-apoptotic activity. Taurus_UMD|evm.model.AC_000178.1.539 Q6NUP7 PP4R4_HUMAN 97.346 0.993056 0.824742 PPP4R4 - Serine/threonine-protein phosphatase 4 regulatory subunit 4 - Homo sapiens (Human) - PPP4R4 gene Putative regulatory subunit of serine/threonine-protein phosphatase 4. Taurus_UMD|evm.model.AC_000178.1.540 Q9UK55 ZPI_HUMAN 66.444 0.966887 1.02027 SERPINA10 - Protein Z-dependent protease inhibitor precursor - Homo sapiens (Human) - SERPINA10 gene Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors. Taurus_UMD|evm.model.AC_000178.1.541 E1BF81 CBG_BOVIN 100.000 0.995062 1.00248 SERPINA6 - Corticosteroid-binding globulin precursor - Bos taurus (Bovine) - SERPINA6 gene Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. Taurus_UMD|evm.model.AC_000178.1.542 P34955 A1AT_BOVIN 100.000 0.995204 1.0024 SERPINA1 - Alpha-1-antiproteinase precursor - Bos taurus (Bovine) - SERPINA1 gene Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Inhibits trypsin, chymotrypsin and plasminogen activator (By similarity). Taurus_UMD|evm.model.AC_000178.1.543 Q86U17 SPA11_HUMAN 79.147 0.995272 1.00237 SERPINA11 - Serpin A11 precursor - Homo sapiens (Human) - SERPINA11 gene extracellular space, serine-type endopeptidase inhibitor activity, negative regulation of endopeptidase activity Taurus_UMD|evm.model.AC_000178.1.544 P46201 UTMP_BOVIN 97.168 0.995526 0.973856 Uterine milk protein precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000178.1.545 Q86WD7 SPA9_HUMAN 66.102 0.866667 0.323741 SERPINA9 - Serpin A9 precursor - Homo sapiens (Human) - SERPINA9 gene Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro). Taurus_UMD|evm.model.AC_000178.1.546 Q8IW75 SPA12_HUMAN 66.425 0.995181 1.00242 SERPINA12 - Serpin A12 precursor - Homo sapiens (Human) - SERPINA12 gene Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. Taurus_UMD|evm.model.AC_000178.1.548 P29622 KAIN_HUMAN 57.244 0.892256 0.69555 SERPINA4 - Kallistatin precursor - Homo sapiens (Human) - SERPINA4 gene Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. Taurus_UMD|evm.model.AC_000178.1.549 Q9N2I2 IPSP_BOVIN 100.000 0.995062 1.00248 SERPINA5 - Plasma serine protease inhibitor precursor - Bos taurus (Bovine) - SERPINA5 gene Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue- and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid (By similarity). Taurus_UMD|evm.model.AC_000178.1.550 Q9TTE1 SPA31_BOVIN 100.000 0.85595 1.16545 SERPINA3-1 - Serpin A3-1 precursor - Bos taurus (Bovine) - SERPINA3-1 gene Potent inhibitor of the serine proteases elastase and trypsin. Moderately inhibits the serine proteases plasmin and chymotrypsin, and the thiol protease proenkephalin-processing enzyme. Does not inhibit the serine proteases cathepsin G, furin, kallikrein, thrombin, tissue plasminogen activator and urokinase, or the cysteine proteases cathepsin B, cathepsin L and papain. Taurus_UMD|evm.model.AC_000178.1.551 Q9P1A6 DLGP2_HUMAN 76.049 0.825119 0.596774 DLGAP2 - Disks large-associated protein 2 - Homo sapiens (Human) - DLGAP2 gene May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Taurus_UMD|evm.model.AC_000178.1.556 P97837 DLGP2_RAT 100.000 0.129464 0.21152 Dlgap2 - Disks large-associated protein 2 - Rattus norvegicus (Rat) - Dlgap2 gene May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Taurus_UMD|evm.model.AC_000178.1.559 Q86X53 ERIC1_HUMAN 56.048 0.592326 0.941309 ERICH1 - Glutamate-rich protein 1 - Homo sapiens (Human) - ERICH1 gene Taurus_UMD|evm.model.AC_000178.1.560 Q13136 LIPA1_HUMAN 71.186 0.298969 0.161398 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000178.1.561 Q13136 LIPA1_HUMAN 67.883 0.716216 0.123128 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000178.1.562 Q3ZEJ6 SPA33_BOVIN 98.684 0.945137 0.975669 SERPINA3-3 - Serpin A3-3 precursor - Bos taurus (Bovine) - SERPINA3-3 gene Serine protease inhibitor. Strongly inhibits elastase and trypsin stoichiometrically at the molar ratio of 1:1. Acts as a moderate inhibitor of plasmin and chymotrypsin. Does not inhibit thrombin, urokinase, kallikrein, tissue plasminogen activator, cathepsin G or the cysteine proteases papain, cathepsin B or cathepsin L. Taurus_UMD|evm.model.AC_000178.1.563 A2I7N3 SPA37_BOVIN 98.801 0.995215 1.0024 SERPINA3-7 - Serpin A3-7 precursor - Bos taurus (Bovine) - SERPINA3-7 gene Serine protease inhibitor. Taurus_UMD|evm.model.AC_000178.1.564 A2I7N1 SPA35_BOVIN 95.631 0.995157 1.00487 SERPINA3-5 - Serpin A3-5 precursor - Bos taurus (Bovine) - SERPINA3-5 gene Serine protease inhibitor. Taurus_UMD|evm.model.AC_000178.1.565 A6QPQ2 SPA38_BOVIN 99.761 0.889126 1.12201 SERPINA3-8 - Serpin A3-8 precursor - Bos taurus (Bovine) - SERPINA3-8 gene Serine protease inhibitor. Taurus_UMD|evm.model.AC_000178.1.566 Q9TTE1 SPA31_BOVIN 68.581 0.871069 0.773723 SERPINA3-1 - Serpin A3-1 precursor - Bos taurus (Bovine) - SERPINA3-1 gene Potent inhibitor of the serine proteases elastase and trypsin. Moderately inhibits the serine proteases plasmin and chymotrypsin, and the thiol protease proenkephalin-processing enzyme. Does not inhibit the serine proteases cathepsin G, furin, kallikrein, thrombin, tissue plasminogen activator and urokinase, or the cysteine proteases cathepsin B, cathepsin L and papain. Taurus_UMD|evm.model.AC_000178.1.567 A2T733 GSC_PANTR 94.882 0.752239 1.3035 GSC - Homeobox protein goosecoid - Pan troglodytes (Chimpanzee) - GSC gene Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity). Taurus_UMD|evm.model.AC_000178.1.568 Q6TUI4 DICER_BOVIN 99.376 0.99896 1 DICER1 - Endoribonuclease Dicer - Bos taurus (Bovine) - DICER1 gene Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity). Taurus_UMD|evm.model.AC_000178.1.571 Q96JQ2 CLMN_HUMAN 95.455 0.178937 0.976048 CLMN - Calmin - Homo sapiens (Human) - CLMN gene cytoplasm, meiotic nuclear membrane microtubule tethering complex, nuclear outer membrane, actin filament binding, negative regulation of cell population proliferation, nuclear migration Taurus_UMD|evm.model.AC_000178.1.572 A2I7N3 SPA37_BOVIN 92.086 0.995215 1.0024 SERPINA3-7 - Serpin A3-7 precursor - Bos taurus (Bovine) - SERPINA3-7 gene Serine protease inhibitor. Taurus_UMD|evm.model.AC_000178.1.573 Q3ZEJ6 SPA33_BOVIN 97.619 0.881857 0.576642 SERPINA3-3 - Serpin A3-3 precursor - Bos taurus (Bovine) - SERPINA3-3 gene Serine protease inhibitor. Strongly inhibits elastase and trypsin stoichiometrically at the molar ratio of 1:1. Acts as a moderate inhibitor of plasmin and chymotrypsin. Does not inhibit thrombin, urokinase, kallikrein, tissue plasminogen activator, cathepsin G or the cysteine proteases papain, cathepsin B or cathepsin L. Taurus_UMD|evm.model.AC_000178.1.574 Q6ZMZ3 SYNE3_HUMAN 77.561 0.997925 0.988718 SYNE3 - Nesprin-3 - Homo sapiens (Human) - SYNE3 gene As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells. Taurus_UMD|evm.model.AC_000178.1.575 Q80Y14 GLRX5_MOUSE 92.126 0.792453 1.04605 Glrx5 - Glutaredoxin-related protein 5, mitochondrial precursor - Mus musculus (Mouse) - Glrx5 gene Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:19442627). Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (By similarity). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (By similarity). Taurus_UMD|evm.model.AC_000178.1.577 O95988 TCL1B_HUMAN 48.387 0.952756 0.992188 TCL1B - T-cell leukemia/lymphoma protein 1B - Homo sapiens (Human) - TCL1B gene Enhances the phosphorylation and activation of AKT1 and AKT2. Taurus_UMD|evm.model.AC_000178.1.578 P56279 TCL1A_HUMAN 61.062 0.948276 1.01754 TCL1A - T-cell leukemia/lymphoma protein 1A - Homo sapiens (Human) - TCL1A gene Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Taurus_UMD|evm.model.AC_000178.1.579 Q9NPU4 CN132_HUMAN 96.386 0.460674 2.14458 C14orf132 - Uncharacterized protein C14orf132 - Homo sapiens (Human) - C14orf132 gene Taurus_UMD|evm.model.AC_000178.1.580 Q9GLX8 BKRB2_PIG 86.704 0.944882 1.03815 BDKRB2 - B2 bradykinin receptor - Sus scrofa (Pig) - BDKRB2 gene Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Taurus_UMD|evm.model.AC_000178.1.581 Q8HZP2 BKRB1_MACMU 77.841 0.994334 1.00284 BDKRB1 - B1 bradykinin receptor - Macaca mulatta (Rhesus macaque) - BDKRB1 gene This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation (By similarity). Taurus_UMD|evm.model.AC_000178.1.582 Q96BY7 ATG2B_HUMAN 93.551 0.999038 1.00048 ATG2B - Autophagy-related protein 2 homolog B - Homo sapiens (Human) - ATG2B gene Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:31721365). Taurus_UMD|evm.model.AC_000178.1.583 Q0P5A3 GSKIP_BOVIN 100.000 0.985714 1.00719 GSKIP - GSK3B-interacting protein - Bos taurus (Bovine) - GSKIP gene A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (By similarity). Taurus_UMD|evm.model.AC_000178.1.584 Q9D2H2 KAD7_MOUSE 88.130 0.846897 1.18078 Ak7 - Adenylate kinase 7 - Mus musculus (Mouse) - Ak7 gene Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function. Taurus_UMD|evm.model.AC_000178.1.585 P25500 PAPOA_BOVIN 100.000 0.997297 1.00135 PAPOLA - Poly(A) polymerase alpha - Bos taurus (Bovine) - PAPOLA gene Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. Taurus_UMD|evm.model.AC_000178.1.587 Q9NR30 DDX21_HUMAN 72.632 0.483871 0.237548 DDX21 - Nucleolar RNA helicase 2 - Homo sapiens (Human) - DDX21 gene RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Taurus_UMD|evm.model.AC_000178.1.588 Q32PI1 VRK1_BOVIN 91.919 0.922535 1.07576 VRK1 - Serine/threonine-protein kinase VRK1 - Bos taurus (Bovine) - VRK1 gene Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity (By similarity). Taurus_UMD|evm.model.AC_000178.1.589 Q66X52 LTOR5_PIG 85.417 0.54023 0.956044 LAMTOR5 - Ragulator complex protein LAMTOR5 - Sus scrofa (Pig) - LAMTOR5 gene As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Taurus_UMD|evm.model.AC_000178.1.593 Q9C0K0 BC11B_HUMAN 96.312 0.994342 0.790828 BCL11B - B-cell lymphoma/leukemia 11B - Homo sapiens (Human) - BCL11B gene Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). Taurus_UMD|evm.model.AC_000178.1.594 Q9C0K0 BC11B_HUMAN 93.007 0.561265 0.282998 BCL11B - B-cell lymphoma/leukemia 11B - Homo sapiens (Human) - BCL11B gene Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). Taurus_UMD|evm.model.AC_000178.1.597 B2KI88 SETD3_RHIFE 93.255 0.981728 1.01347 SETD3 - Actin-histidine N-methyltransferase - Rhinolophus ferrumequinum (Greater horseshoe bat) - SETD3 gene Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73'. Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin. Taurus_UMD|evm.model.AC_000178.1.598 O75909 CCNK_HUMAN 96.220 0.996569 1.00517 CCNK - Cyclin-K - Homo sapiens (Human) - CCNK gene Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). Taurus_UMD|evm.model.AC_000178.1.599 A6NKD9 CC85C_HUMAN 92.683 0.962353 1.01432 CCDC85C - Coiled-coil domain-containing protein 85C - Homo sapiens (Human) - CCDC85C gene May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). Taurus_UMD|evm.model.AC_000178.1.600 Q14DK5 HIPL1_MOUSE 84.509 0.997459 0.994943 Hhipl1 - HHIP-like protein 1 precursor - Mus musculus (Mouse) - Hhipl1 gene Taurus_UMD|evm.model.AC_000178.1.601 Q9Y6A2 CP46A_HUMAN 80.000 0.933333 0.99 CYP46A1 - Cholesterol 24-hydroxylase - Homo sapiens (Human) - CYP46A1 gene P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation (PubMed:10377398, PubMed:14640697, PubMed:25017465, PubMed:18621681). By promoting constant cholesterol elimination in neurons, may activate the mevalonate pathway and coordinate the synthesis of new cholesterol and nonsterol isoprenoids involved in synaptic activity and learning (By similarity). Further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side chain of these molecules, converting them into active oxysterols involved in lipid signaling and biosynthesis (PubMed:12077124, PubMed:14640697, PubMed:28190002). Acts as an epoxidase converting cholesta-5,24-dien-3beta-ol/desmosterol into (24S),25-epoxycholesterol, an abundant lipid ligand of nuclear NR1H2 and NR1H3 receptors shown to promote neurogenesis in developing brain (PubMed:25017465). May also catalyze the oxidative metabolism of xenobiotics, such as clotrimazole (PubMed:20667828). Taurus_UMD|evm.model.AC_000178.1.602 O00423 EMAL1_HUMAN 88.158 0.960114 0.86135 EML1 - Echinoderm microtubule-associated protein-like 1 - Homo sapiens (Human) - EML1 gene Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se. Taurus_UMD|evm.model.AC_000178.1.604 Q0II71 DEGS2_BOVIN 100.000 0.770335 1.29412 DEGS2 - Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 - Bos taurus (Bovine) - DEGS2 gene Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. Taurus_UMD|evm.model.AC_000178.1.605 Q28029 VATF_BOVIN 99.099 0.964912 0.957983 ATP6V1F - V-type proton ATPase subunit F - Bos taurus (Bovine) - ATP6V1F gene Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Taurus_UMD|evm.model.AC_000178.1.606 P25490 TYY1_HUMAN 97.904 0.993994 0.804348 YY1 - Transcriptional repressor protein YY1 - Homo sapiens (Human) - YY1 gene Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). Taurus_UMD|evm.model.AC_000178.1.607 Q08DK7 MCATL_BOVIN 100.000 0.993311 1.00336 SLC25A29 - Mitochondrial basic amino acids transporter - Bos taurus (Bovine) - SLC25A29 gene Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms. Taurus_UMD|evm.model.AC_000178.1.608 Q6Q0C1 S2547_HUMAN 87.220 0.99361 1.01623 SLC25A47 - Solute carrier family 25 member 47 - Homo sapiens (Human) - SLC25A47 gene Uncoupling protein which may catalyze the physiological 'proton leak' in liver. Overexpression induces the dissipation of mitochondrial membrane potential. Taurus_UMD|evm.model.AC_000178.1.609 P17248 SYWC_BOVIN 100.000 0.995807 1.0021 WARS1 - Tryptophan--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - WARS1 gene T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity). Taurus_UMD|evm.model.AC_000178.1.610 Q64LD2 WDR25_HUMAN 76.067 0.996296 0.992647 WDR25 - WD repeat-containing protein 25 - Homo sapiens (Human) - WDR25 gene Taurus_UMD|evm.model.AC_000178.1.611 Q6R6L0 BEGIN_SHEEP 97.214 0.75 1.30475 BEGAIN - Brain-enriched guanylate kinase-associated protein - Ovis aries (Sheep) - BEGAIN gene May sustain the structure of the postsynaptic density (PSD). Taurus_UMD|evm.model.AC_000178.1.614 P80370 DLK1_HUMAN 83.290 0.994792 1.00261 DLK1 - Protein delta homolog 1 precursor - Homo sapiens (Human) - DLK1 gene May have a role in neuroendocrine differentiation. Taurus_UMD|evm.model.AC_000178.1.617 Q52QI2 RTL1_BOVIN 100.000 0.998498 1.00075 RTL1 - Retrotransposon-like protein 1 - Bos taurus (Bovine) - RTL1 gene Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta. Taurus_UMD|evm.model.AC_000178.1.624 Q5I3B1 IOD3_BOVIN 91.007 0.992126 0.843854 DIO3 - Thyroxine 5-deiodinase - Bos taurus (Bovine) - DIO3 gene Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. Taurus_UMD|evm.model.AC_000178.1.625 Q13362 2A5G_HUMAN 94.902 0.875648 1.10496 PPP2R5C - Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform - Homo sapiens (Human) - PPP2R5C gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. Taurus_UMD|evm.model.AC_000178.1.627 Q14204 DYHC1_HUMAN 99.010 0.99957 1 DYNC1H1 - Cytoplasmic dynein 1 heavy chain 1 - Homo sapiens (Human) - DYNC1H1 gene Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). Taurus_UMD|evm.model.AC_000178.1.629 Q76LV2 HS90A_BOVIN 100.000 0.997275 1.00136 HSP90AA1 - Heat shock protein HSP 90-alpha - Bos taurus (Bovine) - HSP90AA1 gene Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Mediates the association of TOMM70 with IRF3 or TBK1 in mitochodria outer membrane which promotes host antiviral response. Taurus_UMD|evm.model.AC_000178.1.630 Q8TBZ3 WDR20_HUMAN 99.355 0.927711 0.29174 WDR20 - WD repeat-containing protein 20 - Homo sapiens (Human) - WDR20 gene Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Taurus_UMD|evm.model.AC_000178.1.631 Q8TBZ3 WDR20_HUMAN 95.707 0.994962 0.697715 WDR20 - WD repeat-containing protein 20 - Homo sapiens (Human) - WDR20 gene Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Taurus_UMD|evm.model.AC_000178.1.632 Q9WVS4 MOK_MOUSE 81.235 0.990453 0.997619 Mok - MAPK/MAK/MRK overlapping kinase - Mus musculus (Mouse) - Mok gene Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (PubMed:10421840). Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner (PubMed:25243405). Taurus_UMD|evm.model.AC_000178.1.633 P51410 RL9_MOUSE 62.644 0.949045 0.817708 Rpl9 - 60S ribosomal protein L9 - Mus musculus (Mouse) - Rpl9 gene cytosol, cytosolic large ribosomal subunit, synapse, structural constituent of ribosome, cytoplasmic translation, translation Taurus_UMD|evm.model.AC_000178.1.635 A8K0R7 ZN839_HUMAN 59.605 0.802752 0.806412 ZNF839 - Zinc finger protein 839 - Homo sapiens (Human) - ZNF839 gene Taurus_UMD|evm.model.AC_000178.1.636 A6H7E2 CINP_BOVIN 100.000 0.696667 1.41509 CINP - Cyclin-dependent kinase 2-interacting protein - Bos taurus (Bovine) - CINP gene Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling (By similarity). Taurus_UMD|evm.model.AC_000178.1.637 O15040 TCPR2_HUMAN 78.151 0.816508 1.03898 TECPR2 - Tectonin beta-propeller repeat-containing protein 2 - Homo sapiens (Human) - TECPR2 gene Probably plays a role as positive regulator of autophagy. Taurus_UMD|evm.model.AC_000178.1.638 O15040 TCPR2_HUMAN 84.906 0.707763 0.155209 TECPR2 - Tectonin beta-propeller repeat-containing protein 2 - Homo sapiens (Human) - TECPR2 gene Probably plays a role as positive regulator of autophagy. Taurus_UMD|evm.model.AC_000178.1.639 Q96BM1 ANKR9_HUMAN 92.453 0.99373 1.00631 ANKRD9 - Ankyrin repeat domain-containing protein 9 - Homo sapiens (Human) - ANKRD9 gene Substrate receptor subunit of a cullin-RING superfamily E3 ligase complex (CUL5-based E3 ubiquitin ligase complex) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:30293565). Depending of the metabolic state of the cell, promotes the proteasomal degradation of IMPDH2, the rate-limiting enzyme in GTP biosynthesis or protects IMPDH2 by stabilizing IMPDH2 filaments assembly (PubMed:30293565, PubMed:31337707). Implicated in different cellular processes, like copper homeostasis and cell proliferation (PubMed:24522796, PubMed:30293565). Taurus_UMD|evm.model.AC_000178.1.640 Q9UKL0 RCOR1_HUMAN 96.448 0.983784 0.762887 RCOR1 - REST corepressor 1 - Homo sapiens (Human) - RCOR1 gene Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Taurus_UMD|evm.model.AC_000178.1.644 O46415 FRIL_BOVIN 96.571 0.988636 1.00571 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000178.1.645 Q60803 TRAF3_MOUSE 95.599 0.974227 1.02646 Traf3 - TNF receptor-associated factor 3 - Mus musculus (Mouse) - Traf3 gene Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. Taurus_UMD|evm.model.AC_000178.1.646 F1SAM7 AMNLS_PIG 72.710 0.982721 0.8921 AMN - Protein amnionless precursor - Sus scrofa (Pig) - AMN gene Membrane-bound component of the endocytic receptor formed by AMN and CUBN (PubMed:30523278). Required for normal CUBN glycosylation and trafficking to the cell surface. The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12. Required for normal CUBN-mediated protein transport in the kidney (By similarity). Taurus_UMD|evm.model.AC_000178.1.648 Q9Y5S2 MRCKB_HUMAN 90.521 0.99375 0.935126 CDC42BPB - Serine/threonine-protein kinase MRCK beta - Homo sapiens (Human) - CDC42BPB gene Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Taurus_UMD|evm.model.AC_000178.1.650 A0A0U1RRK4 LBHD2_HUMAN 57.000 0.539394 1.52778 LBHD2 - LBH domain-containing protein 2 - Homo sapiens (Human) - LBHD2 gene Taurus_UMD|evm.model.AC_000178.1.651 Q17RC7 EX3L4_HUMAN 69.262 0.609349 1.65928 EXOC3L4 - Exocyst complex component 3-like protein 4 - Homo sapiens (Human) - EXOC3L4 gene exocyst, SNARE binding, exocyst localization, exocytosis Taurus_UMD|evm.model.AC_000178.1.652 Q03169 TNAP2_HUMAN 78.689 0.27451 1.01376 TNFAIP2 - Tumor necrosis factor alpha-induced protein 2 - Homo sapiens (Human) - TNFAIP2 gene May play a role as a mediator of inflammation and angiogenesis. Taurus_UMD|evm.model.AC_000178.1.653 Q17RC7 EX3L4_HUMAN 80.000 0.572816 0.142659 EXOC3L4 - Exocyst complex component 3-like protein 4 - Homo sapiens (Human) - EXOC3L4 gene exocyst, SNARE binding, exocyst localization, exocytosis Taurus_UMD|evm.model.AC_000178.1.655 Q8BU31 RAP2C_MOUSE 46.784 0.845771 1.09836 Rap2c - Ras-related protein Rap-2c precursor - Mus musculus (Mouse) - Rap2c gene Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription. Taurus_UMD|evm.model.AC_000178.1.657 Q5R4L0 IF5_PONAB 97.680 0.995349 0.99768 EIF5 - Eukaryotic translation initiation factor 5 - Pongo abelii (Sumatran orangutan) - EIF5 gene Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity). Taurus_UMD|evm.model.AC_000178.1.659 P27448 MARK3_HUMAN 97.147 0.952073 1.02523 MARK3 - MAP/microtubule affinity-regulating kinase 3 - Homo sapiens (Human) - MARK3 gene Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Taurus_UMD|evm.model.AC_000178.1.660 Q5EA61 KCRB_BOVIN 92.443 0.994924 1.03412 CKB - Creatine kinase B-type - Bos taurus (Bovine) - CKB gene Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). Taurus_UMD|evm.model.AC_000178.1.661 A6H791 TRM61_BOVIN 99.649 0.858006 1.1614 TRMT61A - tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A - Bos taurus (Bovine) - TRMT61A gene Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries. Taurus_UMD|evm.model.AC_000178.1.662 Q2TA08 BAG5_BOVIN 100.000 0.995536 1.00224 BAG5 - BAG family molecular chaperone regulator 5 - Bos taurus (Bovine) - BAG5 gene May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). Taurus_UMD|evm.model.AC_000178.1.664 Q148E1 COA8_BOVIN 100.000 0.989637 1.00521 COA8 - Cytochrome c oxidase assembly factor 8 precursor - Bos taurus (Bovine) - COA8 gene Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain. Taurus_UMD|evm.model.AC_000178.1.667 Q5R581 KLC1_PONAB 98.909 0.886914 1.10536 KLC1 - Kinesin light chain 1 - Pongo abelii (Sumatran orangutan) - KLC1 gene Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). Taurus_UMD|evm.model.AC_000178.1.672 Q05B78 ZFY21_BOVIN 100.000 0.990244 0.807087 ZFYVE21 - Zinc finger FYVE domain-containing protein 21 - Bos taurus (Bovine) - ZFYVE21 gene Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression (By similarity). Taurus_UMD|evm.model.AC_000178.1.673 Q96KQ4 ASPP1_HUMAN 90.064 0.998152 0.992661 PPP1R13B - Apoptosis-stimulating of p53 protein 1 - Homo sapiens (Human) - PPP1R13B gene Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Taurus_UMD|evm.model.AC_000178.1.676 P14790 ATP68_BOVIN 96.226 0.353741 2.45 ATP5MJ - ATP synthase subunit ATP5MJ, mitochondrial - Bos taurus (Bovine) - ATP5MJ gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Minor subunit required to maintain the ATP synthase population in the mitochondria. Taurus_UMD|evm.model.AC_000178.1.677 Q8NDG6 TDRD9_HUMAN 82.578 0.998585 1.02243 TDRD9 - ATP-dependent RNA helicase TDRD9 - Homo sapiens (Human) - TDRD9 gene ATP-binding RNA helicase required during spermatogenesis (PubMed:28536242). Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4. Taurus_UMD|evm.model.AC_000178.1.678 Q86U10 LPP60_HUMAN 81.152 0.996503 0.998255 ASPG - 60 kDa lysophospholipase - Homo sapiens (Human) - ASPG gene Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer) (By similarity). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid (By similarity). Taurus_UMD|evm.model.AC_000178.1.679 Q9ULI4 KI26A_HUMAN 74.227 0.489293 0.992561 KIF26A - Kinesin-like protein KIF26A - Homo sapiens (Human) - KIF26A gene Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Taurus_UMD|evm.model.AC_000178.1.686 Q29RM6 NRAC_BOVIN 97.561 0.717647 1.06918 NRAC - Nutritionally-regulated adipose and cardiac-enriched protein homolog - Bos taurus (Bovine) - NRAC gene plasma membrane Taurus_UMD|evm.model.AC_000178.1.687 Q6ZVK1 T179A_HUMAN 95.279 0.991416 1 TMEM179 - Transmembrane protein 179 - Homo sapiens (Human) - TMEM179 gene Taurus_UMD|evm.model.AC_000178.1.689 Q27J81 INF2_HUMAN 84.615 0.397626 0.809448 INF2 - Inverted formin-2 - Homo sapiens (Human) - INF2 gene Severs actin filaments and accelerates their polymerization and depolymerization. Taurus_UMD|evm.model.AC_000178.1.690 A5PJR4 PURA1_BOVIN 100.000 0.995633 1.00219 ADSS1 - Adenylosuccinate synthetase isozyme 1 - Bos taurus (Bovine) - ADSS1 gene Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Taurus_UMD|evm.model.AC_000178.1.691 O15304 SIVA_HUMAN 77.143 0.983051 1.01143 SIVA1 - Apoptosis regulatory protein Siva - Homo sapiens (Human) - SIVA1 gene Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. Taurus_UMD|evm.model.AC_000178.1.692 Q01314 AKT1_BOVIN 90.208 0.828897 1.09583 AKT1 - RAC-alpha serine/threonine-protein kinase - Bos taurus (Bovine) - AKT1 gene AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (By similarity). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (By similarity). AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (By similarity). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth (By similarity). AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) (By similarity). AKT mediates the antiapoptotic effects of IGF-I (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (By similarity). May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53. Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility. Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation. Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (By similarity). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (By similarity). Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity (By similarity). Taurus_UMD|evm.model.AC_000178.1.693 B2RXF5 ZBT42_HUMAN 75.135 0.931818 0.938389 ZBTB42 - Zinc finger and BTB domain-containing protein 42 - Homo sapiens (Human) - ZBTB42 gene Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Taurus_UMD|evm.model.AC_000178.1.694 Q80U49 C170B_MOUSE 94.737 0.373737 0.0628971 Cep170b - Centrosomal protein of 170 kDa protein B - Mus musculus (Mouse) - Cep170b gene Plays a role in microtubule organization. Taurus_UMD|evm.model.AC_000178.1.695 Q9Y4F5 C170B_HUMAN 77.605 0.998748 1.00566 CEP170B - Centrosomal protein of 170 kDa protein B - Homo sapiens (Human) - CEP170B gene Plays a role in microtubule organization. Taurus_UMD|evm.model.AC_000178.1.697 Q96BZ4 PLD4_HUMAN 72.141 0.878788 0.978261 PLD4 - 5'-3' exonuclease PLD4 - Homo sapiens (Human) - PLD4 gene 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia. Taurus_UMD|evm.model.AC_000178.1.698 Q8IVF2 AHNK2_HUMAN 55.789 0.105539 0.295945 AHNAK2 - Protein AHNAK2 - Homo sapiens (Human) - AHNAK2 gene costamere, cytoplasm, cytoplasmic vesicle membrane, cytosol, nucleus, plasma membrane, sarcolemma, T-tubule, Z disc, regulation of RNA splicing Taurus_UMD|evm.model.AC_000178.1.699 Q17QP7 CLBA1_BOVIN 100.000 0.983051 0.35119 CLBA1 - Uncharacterized protein CLBA1 - Bos taurus (Bovine) - CLBA1 gene AP-1 adaptor complex, trans-Golgi network membrane, clathrin binding, intracellular transport Taurus_UMD|evm.model.AC_000178.1.700 Q9BXL8 CDCA4_HUMAN 61.157 0.991031 0.925311 CDCA4 - Cell division cycle-associated protein 4 - Homo sapiens (Human) - CDCA4 gene May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity). Taurus_UMD|evm.model.AC_000178.1.702 Q9UNW8 GP132_HUMAN 66.577 0.709615 1.36842 GPR132 - Probable G-protein coupled receptor 132 - Homo sapiens (Human) - GPR132 gene May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity. Taurus_UMD|evm.model.AC_000178.1.703 P23358 RL12_RAT 44.706 0.924528 0.321212 Rpl12 - 60S ribosomal protein L12 - Rattus norvegicus (Rat) - Rpl12 gene Binds directly to 26S ribosomal RNA. Taurus_UMD|evm.model.AC_000178.1.704 Q9Y219 JAG2_HUMAN 89.282 0.998131 0.864297 JAG2 - Protein jagged-2 precursor - Homo sapiens (Human) - JAG2 gene Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). Taurus_UMD|evm.model.AC_000178.1.705 Q05B60 NUD14_BOVIN 100.000 0.991031 1.0045 NUDT14 - Uridine diphosphate glucose pyrophosphatase NUDT14 - Bos taurus (Bovine) - NUDT14 gene Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose (By similarity). Taurus_UMD|evm.model.AC_000178.1.706 Q92994 TF3B_HUMAN 80.811 0.954614 0.976366 BRF1 - Transcription factor IIIB 90 kDa subunit - Homo sapiens (Human) - BRF1 gene General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. Taurus_UMD|evm.model.AC_000178.1.707 Q86VP3 PACS2_HUMAN 92.623 0.930693 1.0225 PACS2 - Phosphofurin acidic cluster sorting protein 2 - Homo sapiens (Human) - PACS2 gene Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. Taurus_UMD|evm.model.AC_000178.1.708 C9J3V5 TEX22_HUMAN 59.146 0.981928 1.10667 TEX22 - Testis-expressed protein 22 - Homo sapiens (Human) - TEX22 gene Taurus_UMD|evm.model.AC_000178.1.709 Q8K4B0 MTA1_MOUSE 95.751 0.87469 1.12727 Mta1 - Metastasis-associated protein MTA1 - Mus musculus (Mouse) - Mta1 gene Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. With Tfcp2l1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (PubMed:28982712). Taurus_UMD|evm.model.AC_000178.1.710 Q0VFX8 CRIP2_BOVIN 100.000 0.22043 0.894231 CRIP2 - Cysteine-rich protein 2 - Bos taurus (Bovine) - CRIP2 gene Taurus_UMD|evm.model.AC_000178.1.711 Q86SX3 TEDC1_HUMAN 76.316 0.548872 0.268687 TEDC1 - Tubulin epsilon and delta complex protein 1 - Homo sapiens (Human) - TEDC1 gene Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability (By similarity). May play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F (PubMed:28796488). Taurus_UMD|evm.model.AC_000178.1.713 Q56K04 CRIP1_BOVIN 100.000 0.974359 1.01299 CRIP1 - Cysteine-rich protein 1 - Bos taurus (Bovine) - CRIP1 gene Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. Taurus_UMD|evm.model.AC_000178.1.714 Q86SX3 TEDC1_HUMAN 64.000 0.672474 0.579798 TEDC1 - Tubulin epsilon and delta complex protein 1 - Homo sapiens (Human) - TEDC1 gene Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability (By similarity). May play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F (PubMed:28796488). Taurus_UMD|evm.model.AC_000178.1.715 Q8WMY2 FPPS_BOVIN 96.000 0.561086 0.626062 FDPS - Farnesyl pyrophosphate synthase - Bos taurus (Bovine) - FDPS gene Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity). Taurus_UMD|evm.model.AC_000178.1.717 Q80XA0 TM121_MOUSE 97.799 0.99373 1.00314 Tmem121 - Transmembrane protein 121 - Mus musculus (Mouse) - Tmem121 gene May play a role in MAPK signaling. Taurus_UMD|evm.model.AC_000178.1.718 P01877 IGHA2_HUMAN 56.757 0.282366 2.63529 IGHA2 - Immunoglobulin heavy constant alpha 2 - Homo sapiens (Human) - IGHA2 gene Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915). Taurus_UMD|evm.model.AC_000178.1.719 P01871 IGHM_HUMAN 48.287 0.730583 0.909492 IGHM - Immunoglobulin heavy constant mu - Homo sapiens (Human) - IGHM gene Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553). Taurus_UMD|evm.model.AC_000178.1.720 P01820 HVM44_MOUSE 69.091 0.448133 2.09565 Ig heavy chain V region PJ14 precursor - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000178.1.721 P0DP08 HVD82_HUMAN 64.957 0.537383 1.82906 IGHV4-38-2 - Immunoglobulin heavy variable 4-38-2 precursor - Homo sapiens (Human) - IGHV4-38-2 gene V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Taurus_UMD|evm.model.AC_000178.1.722 Q9UKJ8 ADA21_HUMAN 47.015 0.297297 0.614958 ADAM21 - Disintegrin and metalloproteinase domain-containing protein 21 precursor - Homo sapiens (Human) - ADAM21 gene May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients. Taurus_UMD|evm.model.AC_000178.1.723 P0DP01 HV108_HUMAN 88.000 0.292683 0.700855 IGHV1-8 - Immunoglobulin heavy variable 1-8 precursor - Homo sapiens (Human) - IGHV1-8 gene V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Taurus_UMD|evm.model.AC_000178.1.724 P01820 HVM44_MOUSE 66.055 0.877049 1.06087 Ig heavy chain V region PJ14 precursor - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000179.1.1 Q13136 LIPA1_HUMAN 66.667 0.344214 0.280366 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000179.1.2 Q8NGL4 OR5DD_HUMAN 68.212 0.704225 0.678344 OR5D13 - Olfactory receptor 5D13 - Homo sapiens (Human) - OR5D13 gene Odorant receptor. Taurus_UMD|evm.model.AC_000179.1.3 Q9UPS8 ANR26_HUMAN 62.443 0.453502 0.509357 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000179.1.6 Q2M2T7 RT24_BOVIN 100.000 0.988095 1.00599 MRPS24 - 28S ribosomal protein S24, mitochondrial precursor - Bos taurus (Bovine) - MRPS24 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000179.1.7 A0JN92 URGCP_BOVIN 100.000 0.997833 1.00108 URGCP - Up-regulator of cell proliferation - Bos taurus (Bovine) - URGCP gene May be involved in cell cycle progression through the regulation of cyclin D1 expression. Taurus_UMD|evm.model.AC_000179.1.8 Q9Y2X8 UB2D4_HUMAN 99.320 0.935897 1.06122 UBE2D4 - Ubiquitin-conjugating enzyme E2 D4 - Homo sapiens (Human) - UBE2D4 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination. Taurus_UMD|evm.model.AC_000179.1.9 A6H7G2 DBNL_BOVIN 99.764 0.995294 1.00473 DBNL - Drebrin-like protein - Bos taurus (Bovine) - DBNL gene Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes (By similarity). Taurus_UMD|evm.model.AC_000179.1.10 Q32KV0 PGAM2_BOVIN 99.209 0.992126 1.00395 PGAM2 - Phosphoglycerate mutase 2 - Bos taurus (Bovine) - PGAM2 gene Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. Taurus_UMD|evm.model.AC_000179.1.11 A6QNZ8 VOPP1_BOVIN 100.000 0.988439 1.00581 VOPP1 - Vesicular, overexpressed in cancer, prosurvival protein 1 precursor - Bos taurus (Bovine) - VOPP1 gene Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed. Taurus_UMD|evm.model.AC_000179.1.13 Q9NS86 LANC2_HUMAN 87.556 0.982301 1.00444 LANCL2 - LanC-like protein 2 - Homo sapiens (Human) - LANCL2 gene Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. Taurus_UMD|evm.model.AC_000179.1.16 P24049 RL17_RAT 76.087 0.987013 0.836957 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000179.1.17 Q66KU2 SC61G_XENLA 100.000 0.613208 1.55882 sec61g - Protein transport protein Sec61 subunit gamma - Xenopus laevis (African clawed frog) - sec61g gene Necessary for protein translocation in the endoplasmic reticulum and multi-pass membrane protein biogenesis. Taurus_UMD|evm.model.AC_000179.1.18 Q6ZWH5 NEK10_HUMAN 90.537 0.998282 0.993174 NEK10 - Serine/threonine-protein kinase Nek10 - Homo sapiens (Human) - NEK10 gene Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport (PubMed:31959991). Taurus_UMD|evm.model.AC_000179.1.19 Q9Y6M7 S4A7_HUMAN 99.167 0.211131 0.932455 SLC4A7 - Sodium bicarbonate cotransporter 3 - Homo sapiens (Human) - SLC4A7 gene Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. Taurus_UMD|evm.model.AC_000179.1.22 O95936 EOMES_HUMAN 92.482 0.997151 1.02332 EOMES - Eomesodermin homolog - Homo sapiens (Human) - EOMES gene Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. Taurus_UMD|evm.model.AC_000179.1.23 Q3SZM6 COXM1_BOVIN 100.000 0.981308 1.00943 CMC1 - COX assembly mitochondrial protein homolog - Bos taurus (Bovine) - CMC1 gene Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Taurus_UMD|evm.model.AC_000179.1.24 Q3SYW5 AZI2_BOVIN 100.000 0.940048 1.06107 AZI2 - 5-azacytidine-induced protein 2 - Bos taurus (Bovine) - AZI2 gene Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity). Taurus_UMD|evm.model.AC_000179.1.26 Q504Y3 ZCPW2_HUMAN 76.257 0.994398 1.00281 ZCWPW2 - Zinc finger CW-type PWWP domain protein 2 - Homo sapiens (Human) - ZCWPW2 gene Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). Taurus_UMD|evm.model.AC_000179.1.31 Q6XE24 RBMS3_HUMAN 99.361 0.996805 0.716247 RBMS3 - RNA-binding motif, single-stranded-interacting protein 3 - Homo sapiens (Human) - RBMS3 gene Binds poly(A) and poly(U) oligoribonucleotides. Taurus_UMD|evm.model.AC_000179.1.32 P38438 TGFR2_RAT 71.781 0.995624 0.805996 Tgfbr2 - TGF-beta receptor type-2 precursor - Rattus norvegicus (Rat) - Tgfbr2 gene Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity). Taurus_UMD|evm.model.AC_000179.1.33 A6QM00 GADL1_BOVIN 89.544 0.995816 0.917466 GADL1 - Acidic amino acid decarboxylase GADL1 - Bos taurus (Bovine) - GADL1 gene Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is L-aspartate. Does not exhibit any decarboxylation activity toward glutamate. Taurus_UMD|evm.model.AC_000179.1.34 A2SW69 ANXA2_SHEEP 71.779 0.985714 0.412979 ANXA2 - Annexin A2 - Ovis aries (Sheep) - ANXA2 gene Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Taurus_UMD|evm.model.AC_000179.1.35 A2SW69 ANXA2_SHEEP 85.484 0.616162 0.292035 ANXA2 - Annexin A2 - Ovis aries (Sheep) - ANXA2 gene Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Taurus_UMD|evm.model.AC_000179.1.37 E2RG47 STT3B_CANLF 98.789 0.99757 0.996368 STT3B - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B - Canis lupus familiaris (Dog) - STT3B gene Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation (PubMed:12887896). Taurus_UMD|evm.model.AC_000179.1.38 Q9BXB5 OSB10_HUMAN 91.002 0.996604 0.770942 OSBPL10 - Oxysterol-binding protein-related protein 10 - Homo sapiens (Human) - OSBPL10 gene Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). Taurus_UMD|evm.model.AC_000179.1.39 Q8N335 GPD1L_HUMAN 97.429 0.991477 1.00285 GPD1L - Glycerol-3-phosphate dehydrogenase 1-like protein - Homo sapiens (Human) - GPD1L gene Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. Taurus_UMD|evm.model.AC_000179.1.40 Q1RMP9 CKLF8_BOVIN 100.000 0.988506 1.00578 CMTM8 - CKLF-like MARVEL transmembrane domain-containing protein 8 - Bos taurus (Bovine) - CMTM8 gene integral component of membrane, structural constituent of myelin sheath, myelination Taurus_UMD|evm.model.AC_000179.1.41 Q96FZ5 CKLF7_HUMAN 84.483 0.988571 1 CMTM7 - CKLF-like MARVEL transmembrane domain-containing protein 7 - Homo sapiens (Human) - CMTM7 gene integral component of membrane, membrane Taurus_UMD|evm.model.AC_000179.1.42 Q5RFC1 CKLF6_PONAB 71.038 0.989071 1 CMTM6 - CKLF-like MARVEL transmembrane domain-containing protein 6 - Pongo abelii (Sumatran orangutan) - CMTM6 gene Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. Taurus_UMD|evm.model.AC_000179.1.43 Q9Y6G9 DC1L1_HUMAN 94.847 0.99619 1.00382 DYNC1LI1 - Cytoplasmic dynein 1 light intermediate chain 1 - Homo sapiens (Human) - DYNC1LI1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Taurus_UMD|evm.model.AC_000179.1.44 A5JSS2 RL21_CAPHI 96.875 0.987578 1.00625 RPL21 - 60S ribosomal protein L21 - Capra hircus (Goat) - RPL21 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000179.1.45 A4IFB6 CNO10_BOVIN 100.000 0.997312 1.00135 CNOT10 - CCR4-NOT transcription complex subunit 10 - Bos taurus (Bovine) - CNOT10 gene CCR4-NOT complex, mRNA catabolic process, negative regulation of translation Taurus_UMD|evm.model.AC_000179.1.47 E1BJS7 LIN41_BOVIN 99.158 0.953376 0.71659 TRIM71 - E3 ubiquitin-protein ligase TRIM71 - Bos taurus (Bovine) - TRIM71 gene E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (By similarity). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (By similarity). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (By similarity). Taurus_UMD|evm.model.AC_000179.1.49 Q8MJW8 CCR4_CANLF 91.389 0.994444 1 CCR4 - C-C chemokine receptor type 4 - Canis lupus familiaris (Dog) - CCR4 gene High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival (By similarity). Taurus_UMD|evm.model.AC_000179.1.50 Q58D55 BGAL_BOVIN 99.234 0.996942 1.00153 GLB1 - Beta-galactosidase precursor - Bos taurus (Bovine) - GLB1 gene Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Taurus_UMD|evm.model.AC_000179.1.51 Q3ZBM5 SNX5_BOVIN 94.634 0.832653 0.606436 SNX5 - Sorting nexin-5 - Bos taurus (Bovine) - SNX5 gene Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol lipids. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde transport of lysosomal enzyme receptor IGF2R. May function as link between endosomal transport vesicles and dynactin. Plays a role in the internalization of EGFR after EGF stimulation. Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C and is retromer-independent. Together with PIP5K1C facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation. Plays a role in macropinocytosis (By similarity). Taurus_UMD|evm.model.AC_000179.1.52 O75718 CRTAP_HUMAN 95.262 0.995025 1.00249 CRTAP - Cartilage-associated protein precursor - Homo sapiens (Human) - CRTAP gene Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues. Taurus_UMD|evm.model.AC_000179.1.53 O60279 SUSD5_HUMAN 74.331 0.9968 0.993641 SUSD5 - Sushi domain-containing protein 5 precursor - Homo sapiens (Human) - SUSD5 gene Notch signaling pathway Taurus_UMD|evm.model.AC_000179.1.54 A6H779 FBXL2_BOVIN 100.000 0.995283 1.00236 FBXL2 - F-box/LRR-repeat protein 2 - Bos taurus (Bovine) - FBXL2 gene Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy. PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant. Taurus_UMD|evm.model.AC_000179.1.55 Q9NZI7 UBIP1_HUMAN 92.963 0.996276 0.994444 UBP1 - Upstream-binding protein 1 - Homo sapiens (Human) - UBP1 gene Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. Taurus_UMD|evm.model.AC_000179.1.56 O75122 CLAP2_HUMAN 94.806 0.873868 1.10896 CLASP2 - CLIP-associating protein 2 - Homo sapiens (Human) - CLASP2 gene Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. Taurus_UMD|evm.model.AC_000179.1.57 Q8WUM4 PDC6I_HUMAN 95.429 0.997717 1.00922 PDCD6IP - Programmed cell death 6-interacting protein - Homo sapiens (Human) - PDCD6IP gene Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17853893, PubMed:17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17853893, PubMed:17556548, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). Taurus_UMD|evm.model.AC_000179.1.62 Q7M2N1 ARP21_BOVIN 100.000 0.0913921 10.573 ARPP21 - cAMP-regulated phosphoprotein 21 - Bos taurus (Bovine) - ARPP21 gene May act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. Taurus_UMD|evm.model.AC_000179.1.64 A0JNJ1 STAC_BOVIN 85.360 0.99422 0.858561 STAC - SH3 and cysteine-rich domain-containing protein - Bos taurus (Bovine) - STAC gene Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. Taurus_UMD|evm.model.AC_000179.1.65 Q2T9W6 LRRF2_BOVIN 99.500 0.995012 1.0025 LRRFIP2 - Leucine-rich repeat flightless-interacting protein 2 - Bos taurus (Bovine) - LRRFIP2 gene May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity). Taurus_UMD|evm.model.AC_000179.1.66 P40692 MLH1_HUMAN 91.029 0.997365 1.00397 MLH1 - DNA mismatch repair protein Mlh1 - Homo sapiens (Human) - MLH1 gene Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis. Taurus_UMD|evm.model.AC_000179.1.67 Q7L775 EPMIP_HUMAN 83.882 0.996716 1.00329 EPM2AIP1 - EPM2A-interacting protein 1 - Homo sapiens (Human) - EPM2AIP1 gene identical protein binding, positive regulation of glycogen (starch) synthase activity, positive regulation of glycogen biosynthetic process, response to insulin Taurus_UMD|evm.model.AC_000179.1.68 O15050 TRNK1_HUMAN 80.887 0.975863 1.01983 TRANK1 - TPR and ankyrin repeat-containing protein 1 - Homo sapiens (Human) - TRANK1 gene Taurus_UMD|evm.model.AC_000179.1.69 Q9C098 DCLK3_HUMAN 77.414 0.808729 1.20216 DCLK3 - Serine/threonine-protein kinase DCLK3 - Homo sapiens (Human) - DCLK3 gene cytoplasm, nucleus, protein kinase activity, peptidyl-serine phosphorylation Taurus_UMD|evm.model.AC_000179.1.71 Q13439 GOGA4_HUMAN 82.808 0.999111 1.00897 GOLGA4 - Golgin subfamily A member 4 - Homo sapiens (Human) - GOLGA4 gene Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). Taurus_UMD|evm.model.AC_000179.1.72 Q13797 ITA9_HUMAN 91.829 0.963979 0.563285 ITGA9 - Integrin alpha-9 precursor - Homo sapiens (Human) - ITGA9 gene Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Taurus_UMD|evm.model.AC_000179.1.73 Q13797 ITA9_HUMAN 92.157 0.34965 0.138164 ITGA9 - Integrin alpha-9 precursor - Homo sapiens (Human) - ITGA9 gene Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Taurus_UMD|evm.model.AC_000179.1.74 P13620 ATP5H_BOVIN 84.821 0.982301 0.701863 ATP5PD - ATP synthase subunit d, mitochondrial - Bos taurus (Bovine) - ATP5PD gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Taurus_UMD|evm.model.AC_000179.1.75 Q13797 ITA9_HUMAN 93.484 0.995 0.386473 ITGA9 - Integrin alpha-9 precursor - Homo sapiens (Human) - ITGA9 gene Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Taurus_UMD|evm.model.AC_000179.1.77 O15194 CTDSL_HUMAN 97.101 0.99278 1.00362 CTDSPL - CTD small phosphatase-like protein - Homo sapiens (Human) - CTDSPL gene Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Taurus_UMD|evm.model.AC_000179.1.78 O15195 VILL_HUMAN 74.048 0.997693 1.01285 VILL - Villin-like protein - Homo sapiens (Human) - VILL gene Possible tumor suppressor. Taurus_UMD|evm.model.AC_000179.1.79 P10895 PLCD1_BOVIN 100.000 0.997358 1.00132 PLCD1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 - Bos taurus (Bovine) - PLCD1 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential for trophoblast and placental development (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (By similarity). Taurus_UMD|evm.model.AC_000179.1.80 Q9Y238 DLEC1_HUMAN 75.995 0.998263 0.984046 DLEC1 - Deleted in lung and esophageal cancer protein 1 - Homo sapiens (Human) - DLEC1 gene Essential for spermatogenesis and male fertility (By similarity). May play an important role in sperm head and tail formation (By similarity). May act as a tumor suppressor by inhibiting cell proliferation. Taurus_UMD|evm.model.AC_000179.1.81 P09110 THIK_HUMAN 91.509 0.995294 1.00236 ACAA1 - 3-ketoacyl-CoA thiolase, peroxisomal precursor - Homo sapiens (Human) - ACAA1 gene Responsible for the thiolytic cleavage of straight chain 3-oxoacyl-CoAs. Catalyzes the cleavage of short, medium and long straight chain 3-oxoacyl-CoAs, medium chain 3-oxoacyl-CoAs being the best substrates. Taurus_UMD|evm.model.AC_000179.1.82 Q599T9 MYD88_BOVIN 100.000 0.993266 1.00338 MYD88 - Myeloid differentiation primary response protein MyD88 - Bos taurus (Bovine) - MYD88 gene Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (PubMed:17936907, PubMed:18760477). Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). Taurus_UMD|evm.model.AC_000179.1.83 Q5R495 OXSR1_PONAB 97.533 0.996212 1.0019 OXSR1 - Serine/threonine-protein kinase OSR1 - Pongo abelii (Sumatran orangutan) - OXSR1 gene Phosphorylates RELL1, RELL2, RELT and PAK1. Phosphorylates PLSCR1 in the presence of RELT. Taurus_UMD|evm.model.AC_000179.1.84 Q9Y226 S22AD_HUMAN 76.190 0.247619 0.76225 SLC22A13 - Solute carrier family 22 member 13 - Homo sapiens (Human) - SLC22A13 gene apical plasma membrane, endoplasmic reticulum, extracellular exosome, Golgi apparatus, plasma membrane, nicotinate transmembrane transporter activity, NAD biosynthesis via nicotinamide riboside salvage pathway, negative regulation of fatty acid metabolic process, nicotinate transport, positive regulation of T cell mediated cytotoxicity directed against tumor cell target Taurus_UMD|evm.model.AC_000179.1.85 Q9Y267 S22AE_HUMAN 61.101 0.930153 0.988215 SLC22A14 - Solute carrier family 22 member 14 - Homo sapiens (Human) - SLC22A14 gene Essential for male fertility, sperm motility and normal sperm flagellar structure. Taurus_UMD|evm.model.AC_000179.1.86 Q3SYZ6 XYLB_BOVIN 100.000 0.891993 1.09592 XYLB - Xylulose kinase - Bos taurus (Bovine) - XYLB gene Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. Taurus_UMD|evm.model.AC_000179.1.87 Q95126 AVR2B_BOVIN 99.805 0.996101 1.00195 ACVR2B - Activin receptor type-2B precursor - Bos taurus (Bovine) - ACVR2B gene Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor (By similarity). Taurus_UMD|evm.model.AC_000179.1.88 Q9Y2C4 EXOG_HUMAN 85.326 0.99458 1.00272 EXOG - Nuclease EXOG, mitochondrial precursor - Homo sapiens (Human) - EXOG gene Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity. Taurus_UMD|evm.model.AC_000179.1.89 Q9JJV9 SCN5A_MOUSE 92.787 0.958175 1.0421 Scn5a - Sodium channel protein type 5 subunit alpha - Mus musculus (Mouse) - Scn5a gene This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:11834499, PubMed:23420830). It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels (By similarity). Taurus_UMD|evm.model.AC_000179.1.90 O46669 SCNAA_CANLF 84.326 0.991816 0.996432 SCN10A - Sodium channel protein type 10 subunit alpha - Canis lupus familiaris (Dog) - SCN10A gene Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms (By similarity). Taurus_UMD|evm.model.AC_000179.1.91 Q9UI33 SCNBA_HUMAN 76.610 0.99889 1.00614 SCN11A - Sodium channel protein type 11 subunit alpha - Homo sapiens (Human) - SCN11A gene This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. Taurus_UMD|evm.model.AC_000179.1.92 Q8TAF3 WDR48_HUMAN 99.852 0.99705 1.00148 WDR48 - WD repeat-containing protein 48 - Homo sapiens (Human) - WDR48 gene Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:31253762, PubMed:26388029). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604, PubMed:31253762). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27650958, PubMed:27373336). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27650958, PubMed:27373336). Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination (PubMed:27463890, PubMed:27239033, PubMed:32350107). Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) (PubMed:27239033, PubMed:31253762, PubMed:32350107). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes (PubMed:31253762, PubMed:32350107). Taurus_UMD|evm.model.AC_000179.1.93 Q9BQQ3 GORS1_HUMAN 79.863 0.957778 1.02273 GORASP1 - Golgi reassembly-stacking protein 1 - Homo sapiens (Human) - GORASP1 gene Plays an important role in assembly and membrane stacking of the Golgi cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (PubMed:26363069). Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). Taurus_UMD|evm.model.AC_000179.1.94 Q8NDW8 TT21A_HUMAN 79.334 0.998445 0.974242 TTC21A - Tetratricopeptide repeat protein 21A - Homo sapiens (Human) - TTC21A gene Intraflagellar transport (IFT)-associated protein required for spermatogenesis (PubMed:30929735). Required for sperm flagellar formation and intraflagellar transport (PubMed:30929735). Taurus_UMD|evm.model.AC_000179.1.95 Q96S65 CSRN1_HUMAN 82.770 0.965461 1.03226 CSRNP1 - Cysteine/serine-rich nuclear protein 1 - Homo sapiens (Human) - CSRNP1 gene Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis. Taurus_UMD|evm.model.AC_000179.1.96 O70373 XIRP1_MOUSE 74.494 0.611752 1.61293 Xirp1 - Xin actin-binding repeat-containing protein 1 - Mus musculus (Mouse) - Xirp1 gene Protects actin filaments from depolymerization. Taurus_UMD|evm.model.AC_000179.1.97 A6QNL7 CX3C1_BOVIN 100.000 0.994429 1.00279 CX3CR1 - CX3C chemokine receptor 1 - Bos taurus (Bovine) - CX3CR1 gene Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. CX3CR1-CX3CL1 signaling mediates cell migratory functions. Responsible for the recruitment of natural killer (NK) cells to inflamed tissues. Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival. Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung. Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells. Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis. Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation. Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli. Involved in brain development by participating to synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development. Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development. Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi. Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria. Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection (By similarity). Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (By similarity). Taurus_UMD|evm.model.AC_000179.1.98 Q08E15 SIA7F_BOVIN 62.896 0.989583 0.578313 ST6GALNAC6 - Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 - Bos taurus (Bovine) - ST6GALNAC6 gene Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (By similarity). Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity). Taurus_UMD|evm.model.AC_000179.1.99 P51685 CCR8_HUMAN 81.690 0.994334 0.994366 CCR8 - C-C chemokine receptor type 8 - Homo sapiens (Human) - CCR8 gene Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. Taurus_UMD|evm.model.AC_000179.1.100 Q5EAC0 S2538_BOVIN 100.000 0.585413 1.70261 SLC25A38 - Mitochondrial glycine transporter - Bos taurus (Bovine) - SLC25A38 gene Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis. Taurus_UMD|evm.model.AC_000179.1.101 P55215 CASP2_RAT 39.597 0.371274 0.816372 Casp2 - Caspase-2 precursor - Rattus norvegicus (Rat) - Casp2 gene Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (By similarity). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (By similarity). Taurus_UMD|evm.model.AC_000179.1.102 P26452 RSSA_BOVIN 100.000 0.993243 1.00339 RPSA - 40S ribosomal protein SA - Bos taurus (Bovine) - RPSA gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. Taurus_UMD|evm.model.AC_000179.1.104 Q63327 MOBP_RAT 78.488 0.987013 0.905882 Mobp - Myelin-associated oligodendrocyte basic protein - Rattus norvegicus (Rat) - Mobp gene May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane. Taurus_UMD|evm.model.AC_000179.1.105 Q8NFW9 MYRIP_HUMAN 83.510 0.907427 1.08149 MYRIP - Rab effector MyRIP - Homo sapiens (Human) - MYRIP gene Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). Taurus_UMD|evm.model.AC_000179.1.106 P61220 EIF1B_PIG 100.000 0.982456 1.00885 EIF1B - Eukaryotic translation initiation factor 1b - Sus scrofa (Pig) - EIF1B gene Probably involved in translation. Taurus_UMD|evm.model.AC_000179.1.107 O75355 ENTP3_HUMAN 79.584 0.996226 1.00189 ENTPD3 - Ectonucleoside triphosphate diphosphohydrolase 3 - Homo sapiens (Human) - ENTPD3 gene Has a threefold preference for the hydrolysis of ATP over ADP. Taurus_UMD|evm.model.AC_000179.1.108 Q3T0U2 RL14_BOVIN 99.533 0.990654 1 RPL14 - 60S ribosomal protein L14 - Bos taurus (Bovine) - RPL14 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000179.1.109 Q8N2I2 ZN619_HUMAN 78.866 0.994859 0.694643 ZNF619 - Zinc finger protein 619 - Homo sapiens (Human) - ZNF619 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000179.1.110 Q6ZSS3 ZN621_HUMAN 70.709 0.957143 0.95672 ZNF621 - Zinc finger protein 621 - Homo sapiens (Human) - ZNF621 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000179.1.111 Q6ZSS3 ZN621_HUMAN 82.093 0.940265 1.02961 ZNF621 - Zinc finger protein 621 - Homo sapiens (Human) - ZNF621 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000179.1.113 P31081 CH60_BOVIN 100.000 0.996516 1.00175 HSPD1 - 60 kDa heat shock protein, mitochondrial precursor - Bos taurus (Bovine) - HSPD1 gene Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein. Taurus_UMD|evm.model.AC_000179.1.117 B6V8E6 CTNB1_CANLF 100.000 0.997442 1.00128 CTNNB1 - Catenin beta-1 - Canis lupus familiaris (Dog) - CTNNB1 gene Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (By similarity). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Taurus_UMD|evm.model.AC_000179.1.118 Q5R4M2 ULK4_PONAB 88.889 0.898175 0.816471 ULK4 - Serine/threonine-protein kinase ULK4 - Pongo abelii (Sumatran orangutan) - ULK4 gene May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility. Taurus_UMD|evm.model.AC_000179.1.119 Q8WTS1 ABHD5_HUMAN 94.842 0.754348 1.31805 ABHD5 - 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 - Homo sapiens (Human) - ABHD5 gene Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid (PubMed:18606822). Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (PubMed:18606822). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (PubMed:18832586). Regulates lipid droplet fusion (By similarity). Taurus_UMD|evm.model.AC_000179.1.120 P49914 MTHFS_HUMAN 65.000 0.938889 0.8867 MTHFS - 5-formyltetrahydrofolate cyclo-ligase - Homo sapiens (Human) - MTHFS gene Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate. Taurus_UMD|evm.model.AC_000179.1.121 Q8N6M0 OTU6B_HUMAN 89.796 0.986395 0.501706 OTUD6B - Deubiquitinase OTUD6B - Homo sapiens (Human) - OTUD6B gene Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334). May also play a role in proteasome assembly and function (PubMed:28343629). Taurus_UMD|evm.model.AC_000179.1.122 Q96C45 ULK4_HUMAN 91.322 0.979675 0.192941 ULK4 - Serine/threonine-protein kinase ULK4 - Homo sapiens (Human) - ULK4 gene May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility. Taurus_UMD|evm.model.AC_000179.1.123 Q6PD31 TRAK1_MOUSE 91.549 0.460526 0.161874 Trak1 - Trafficking kinesin-binding protein 1 - Mus musculus (Mouse) - Trak1 gene Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (By similarity). Involved in mitochondrial motility (PubMed:24995978). When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (By similarity). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). Taurus_UMD|evm.model.AC_000179.1.124 Q9UPV9 TRAK1_HUMAN 86.004 0.985961 0.971668 TRAK1 - Trafficking kinesin-binding protein 1 - Homo sapiens (Human) - TRAK1 gene Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). Taurus_UMD|evm.model.AC_000179.1.125 P41520 CCKN_BOVIN 99.130 0.982759 1.0087 CCK - Cholecystokinin precursor - Bos taurus (Bovine) - CCK gene This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. Taurus_UMD|evm.model.AC_000179.1.127 Q2T9N7 LYZL4_BOVIN 99.310 0.986301 1.0069 LYZL4 - Lysozyme-like protein 4 precursor - Bos taurus (Bovine) - LYZL4 gene May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity). Taurus_UMD|evm.model.AC_000179.1.128 Q28992 VIPR1_PIG 89.325 0.995652 1.00437 VIPR1 - Vasoactive intestinal polypeptide receptor 1 precursor - Sus scrofa (Pig) - VIPR1 gene This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Taurus_UMD|evm.model.AC_000179.1.129 Q2YDJ2 SC22C_BOVIN 100.000 0.993421 1.0033 SEC22C - Vesicle-trafficking protein SEC22c - Bos taurus (Bovine) - SEC22C gene May be involved in vesicle transport between the ER and the Golgi complex. Taurus_UMD|evm.model.AC_000179.1.130 P30414 NKTR_HUMAN 89.563 0.998633 1.00068 NKTR - NK-tumor recognition protein - Homo sapiens (Human) - NKTR gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). Taurus_UMD|evm.model.AC_000179.1.131 Q9UFB7 ZBT47_HUMAN 95.636 0.599562 0.61178 ZBTB47 - Zinc finger and BTB domain-containing protein 47 - Homo sapiens (Human) - ZBTB47 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000179.1.132 Q9UFB7 ZBT47_HUMAN 97.628 0.860068 0.392236 ZBTB47 - Zinc finger and BTB domain-containing protein 47 - Homo sapiens (Human) - ZBTB47 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000179.1.133 Q2TBA0 KLH40_HUMAN 92.949 0.9968 1.00644 KLHL40 - Kelch-like protein 40 - Homo sapiens (Human) - KLHL40 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:23746549). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity). Taurus_UMD|evm.model.AC_000179.1.134 Q9HCP6 HHATL_HUMAN 80.671 0.995565 0.894841 HHATL - Protein-cysteine N-palmitoyltransferase HHAT-like protein - Homo sapiens (Human) - HHATL gene Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN. Taurus_UMD|evm.model.AC_000179.1.135 Q8IYE1 CCD13_HUMAN 85.714 0.995804 1 CCDC13 - Coiled-coil domain-containing protein 13 - Homo sapiens (Human) - CCDC13 gene Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia. Taurus_UMD|evm.model.AC_000179.1.136 Q8VH49 HIG1A_RAT 87.097 0.671533 1.47312 Higd1a - HIG1 domain family member 1A, mitochondrial - Rattus norvegicus (Rat) - Higd1a gene Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). Taurus_UMD|evm.model.AC_000179.1.137 O00590 ACKR2_HUMAN 79.112 0.976623 1.0026 ACKR2 - Atypical chemokine receptor 2 - Homo sapiens (Human) - ACKR2 gene Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs. Taurus_UMD|evm.model.AC_000179.1.138 O00590 ACKR2_HUMAN 76.042 0.510753 0.484375 ACKR2 - Atypical chemokine receptor 2 - Homo sapiens (Human) - ACKR2 gene Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs. Taurus_UMD|evm.model.AC_000179.1.139 Q7YRB2 CP8B1_PIG 86.028 0.996 0.998004 CYP8B1 - 5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase - Sus scrofa (Pig) - CYP8B1 gene A cytochrome P450 monooxygenase involved in primary bile acid biosynthesis. Catalyzes the 12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one, an intermediate metabolite in cholic acid biosynthesis (PubMed:14643796). Controls biliary balance of cholic acid and chenodeoxycholic acid, ultimately regulating the intestinal absorption of dietary lipids (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase) (By similarity). Taurus_UMD|evm.model.AC_000179.1.140 Q9UFP1 GAK1A_HUMAN 58.333 0.985507 0.48 GASK1A - Golgi-associated kinase 1A precursor - Homo sapiens (Human) - GASK1A gene endoplasmic reticulum, extracellular region, Golgi apparatus, intracellular membrane-bounded organelle Taurus_UMD|evm.model.AC_000179.1.141 Q9UFP1 GAK1A_HUMAN 86.986 0.960265 0.262609 GASK1A - Golgi-associated kinase 1A precursor - Homo sapiens (Human) - GASK1A gene endoplasmic reticulum, extracellular region, Golgi apparatus, intracellular membrane-bounded organelle Taurus_UMD|evm.model.AC_000179.1.142 Q5NDF2 PMGT2_BOVIN 100.000 0.996558 1.00172 POMGNT2 - Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 - Bos taurus (Bovine) - POMGNT2 gene O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Taurus_UMD|evm.model.AC_000179.1.143 Q9NRH2 SNRK_HUMAN 94.970 0.899725 0.951634 SNRK - SNF-related serine/threonine-protein kinase - Homo sapiens (Human) - SNRK gene May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis. Taurus_UMD|evm.model.AC_000179.1.144 Q9NW15 ANO10_HUMAN 86.018 0.99095 1.00455 ANO10 - Anoctamin-10 - Homo sapiens (Human) - ANO10 gene Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. Taurus_UMD|evm.model.AC_000179.1.145 G7H7V7 TOPZ1_BOVIN 100.000 0.998791 1.0006 TOPAZ1 - Protein TOPAZ1 - Bos taurus (Bovine) - TOPAZ1 gene Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear. Taurus_UMD|evm.model.AC_000179.1.146 Q8N3R3 TCAIM_HUMAN 92.339 0.995976 1.00202 TCAIM - T-cell activation inhibitor, mitochondrial - Homo sapiens (Human) - TCAIM gene May regulate T-cell apoptosis. Taurus_UMD|evm.model.AC_000179.1.147 P0DN24 CC086_HUMAN 53.333 0.509901 2 C3orf86 - Uncharacterized protein C3orf86 - Homo sapiens (Human) - C3orf86 gene Taurus_UMD|evm.model.AC_000179.1.148 Q2HJI3 F136A_BOVIN 86.957 0.985612 1.00725 FAM136A - Protein FAM136A - Bos taurus (Bovine) - FAM136A gene cytoplasm Taurus_UMD|evm.model.AC_000179.1.149 P59923 ZN445_HUMAN 76.960 0.998054 0.99709 ZNF445 - Zinc finger protein 445 - Homo sapiens (Human) - ZNF445 gene Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). Taurus_UMD|evm.model.AC_000179.1.150 P68105 EF1A1_RABIT 98.485 0.97037 0.292208 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000179.1.151 Q96LW9 ZSC31_HUMAN 75.325 0.269504 0.694581 ZSCAN31 - Zinc finger and SCAN domain-containing protein 31 - Homo sapiens (Human) - ZSCAN31 gene May function as a transcription factor. May be involved in the development of multiple embryonic organs. Taurus_UMD|evm.model.AC_000179.1.152 Q6AZW8 ZN660_HUMAN 93.051 0.993884 0.987915 ZNF660 - Zinc finger protein 660 - Homo sapiens (Human) - ZNF660 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000179.1.153 P68105 EF1A1_RABIT 97.633 0.565436 1.29004 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000179.1.154 O14709 ZN197_HUMAN 92.416 0.997429 0.756074 ZNF197 - Zinc finger protein 197 - Homo sapiens (Human) - ZNF197 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000179.1.155 P13682 ZNF35_HUMAN 88.805 0.992453 1.00569 ZNF35 - Zinc finger protein 35 - Homo sapiens (Human) - ZNF35 gene May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation. Taurus_UMD|evm.model.AC_000179.1.156 Q8TBZ5 ZN502_HUMAN 87.716 0.994231 0.955882 ZNF502 - Zinc finger protein 502 - Homo sapiens (Human) - ZNF502 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000179.1.157 Q3MHJ0 K1143_BOVIN 100.000 0.987261 1.00641 Uncharacterized protein KIAA1143 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000179.1.158 Q9NS87 KIF15_HUMAN 88.320 0.99784 1.00072 KIF15 - Kinesin-like protein KIF15 - Homo sapiens (Human) - KIF15 gene Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. Taurus_UMD|evm.model.AC_000179.1.159 Q93075 TATD2_HUMAN 76.654 0.963777 1.01577 TATDN2 - Putative deoxyribonuclease TATDN2 - Homo sapiens (Human) - TATDN2 gene Putative deoxyribonuclease. Taurus_UMD|evm.model.AC_000179.1.160 Q0P5I2 IRAK2_BOVIN 100.000 0.996785 1.00161 IRAK2 - Interleukin-1 receptor-associated kinase-like 2 - Bos taurus (Bovine) - IRAK2 gene Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Taurus_UMD|evm.model.AC_000179.1.161 Q5Q9Z2 VHL_CANLF 84.974 0.979381 0.885845 VHL - von Hippel-Lindau disease tumor suppressor - Canis lupus familiaris (Dog) - VHL gene Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (By similarity). Taurus_UMD|evm.model.AC_000179.1.162 Q6IQ86 BRK1_DANRE 100.000 0.973684 1.01333 brk1 - Probable protein BRICK1 - Danio rerio (Zebrafish) - brk1 gene Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity). Taurus_UMD|evm.model.AC_000179.1.163 Q32KZ5 FACOS_BOVIN 100.000 0.988827 1.00562 FANCD2OS - FANCD2 opposite strand protein - Bos taurus (Bovine) - FANCD2OS gene Taurus_UMD|evm.model.AC_000179.1.164 Q9BXW9 FACD2_HUMAN 80.361 0.991573 0.981392 FANCD2 - Fanconi anemia group D2 protein - Homo sapiens (Human) - FANCD2 gene Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching. Taurus_UMD|evm.model.AC_000179.1.165 Q3ZCB8 EMC3_BOVIN 93.487 0.992366 1.00383 EMC3 - ER membrane protein complex subunit 3 - Bos taurus (Bovine) - EMC3 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Taurus_UMD|evm.model.AC_000179.1.166 Q5FWE3 PRRT3_HUMAN 80.163 0.956863 1.03976 PRRT3 - Proline-rich transmembrane protein 3 precursor - Homo sapiens (Human) - PRRT3 gene Taurus_UMD|evm.model.AC_000179.1.167 Q5EA46 CREL1_BOVIN 99.762 0.995249 1.00238 CRELD1 - Protein disulfide isomerase CRELD1 precursor - Bos taurus (Bovine) - CRELD1 gene Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity). Taurus_UMD|evm.model.AC_000179.1.168 Q8NAC3 I17RC_HUMAN 85.714 0.0474198 0.906448 IL17RC - Interleukin-17 receptor C precursor - Homo sapiens (Human) - IL17RC gene Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (By similarity). Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:16785495, PubMed:32187518). Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (By similarity). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:18684971, PubMed:17911633). Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Taurus_UMD|evm.model.AC_000179.1.169 Q8NFR9 I17RE_HUMAN 77.083 0.995208 0.938531 IL17RE - Interleukin-17 receptor E precursor - Homo sapiens (Human) - IL17RE gene Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. Taurus_UMD|evm.model.AC_000179.1.170 Q2NKY9 JAGN1_BOVIN 100.000 0.98913 1.00546 JAGN1 - Protein jagunal homolog 1 - Bos taurus (Bovine) - JAGN1 gene Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils. Taurus_UMD|evm.model.AC_000179.1.171 F1MN90 CIDEC_BOVIN 98.649 0.928571 1.07207 CIDEC - Cell death activator CIDE-3 - Bos taurus (Bovine) - CIDEC gene Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. The physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression (By similarity). Taurus_UMD|evm.model.AC_000179.1.172 Q2TBK7 RUSD3_BOVIN 99.709 0.994203 1.00291 RPUSD3 - Mitochondrial mRNA pseudouridine synthase RPUSD3 precursor - Bos taurus (Bovine) - RPUSD3 gene Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis. Taurus_UMD|evm.model.AC_000179.1.173 A4Q9E5 TTLL3_MOUSE 85.197 0.9 0.755124 Ttll3 - Tubulin monoglycylase TTLL3 - Mus musculus (Mouse) - Ttll3 gene Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction. Taurus_UMD|evm.model.AC_000179.1.174 P59999 ARPC4_MOUSE 100.000 0.988166 1.00595 Arpc4 - Actin-related protein 2/3 complex subunit 4 - Mus musculus (Mouse) - Arpc4 gene Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Taurus_UMD|evm.model.AC_000179.1.175 O75528 TADA3_HUMAN 98.182 0.995465 1.02083 TADA3 - Transcriptional adapter 3 - Homo sapiens (Human) - TADA3 gene Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Taurus_UMD|evm.model.AC_000179.1.176 Q63450 KCC1A_RAT 96.961 0.973046 0.991979 Camk1 - Calcium/calmodulin-dependent protein kinase type 1 - Rattus norvegicus (Rat) - Camk1 gene Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-516', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation (By similarity). Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-275' and 'Ser-294'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. Taurus_UMD|evm.model.AC_000179.1.177 O15527 OGG1_HUMAN 86.377 0.988506 1.0087 OGG1 - N-glycosylase/DNA lyase - Homo sapiens (Human) - OGG1 gene DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Taurus_UMD|evm.model.AC_000179.1.178 P55201 BRPF1_HUMAN 98.847 0.991006 1.00741 BRPF1 - Peregrin - Homo sapiens (Human) - BRPF1 gene Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). Taurus_UMD|evm.model.AC_000179.1.179 Q8IYJ1 CPNE9_HUMAN 98.373 0.996383 1 CPNE9 - Copine-9 - Homo sapiens (Human) - CPNE9 gene Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Taurus_UMD|evm.model.AC_000179.1.180 Q8NCE2 MTMRE_HUMAN 93.142 0.963077 1 MTMR14 - Myotubularin-related protein 14 - Homo sapiens (Human) - MTMR14 gene Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Taurus_UMD|evm.model.AC_000179.1.181 Q17R16 LHPL4_BOVIN 100.000 0.792899 0.684211 LHFPL4 - LHFPL tetraspan subfamily member 4 protein - Bos taurus (Bovine) - LHFPL4 gene Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs. Taurus_UMD|evm.model.AC_000179.1.182 Q9C0A6 SETD5_HUMAN 93.952 0.998624 1.00763 SETD5 - Histone-lysine N-methyltransferase SETD5 - Homo sapiens (Human) - SETD5 gene Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. Taurus_UMD|evm.model.AC_000179.1.183 Q2T9W2 THUM3_BOVIN 99.801 0.994048 0.996047 THUMPD3 - THUMP domain-containing protein 3 - Bos taurus (Bovine) - THUMPD3 gene Taurus_UMD|evm.model.AC_000179.1.184 O43295 SRGP3_HUMAN 99.272 0.998182 1.00091 SRGAP3 - SLIT-ROBO Rho GTPase-activating protein 3 - Homo sapiens (Human) - SRGAP3 gene GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. Taurus_UMD|evm.model.AC_000179.1.185 Q9NS91 RAD18_HUMAN 81.710 0.996016 1.01414 RAD18 - E3 ubiquitin-protein ligase RAD18 - Homo sapiens (Human) - RAD18 gene E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. Taurus_UMD|evm.model.AC_000179.1.186 P56449 OXYR_BOVIN 100.000 0.994898 1.00256 OXTR - Oxytocin receptor - Bos taurus (Bovine) - OXTR gene Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000179.1.187 Q2KI43 CAV3_BOVIN 100.000 0.986842 1.00662 CAV3 - Caveolin-3 - Bos taurus (Bovine) - CAV3 gene May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. Taurus_UMD|evm.model.AC_000179.1.188 Q9Y2M2 SSUH2_HUMAN 87.582 0.724466 1.19263 SSUH2 - Protein SSUH2 homolog - Homo sapiens (Human) - SSUH2 gene Plays a role in odontogenesis. Taurus_UMD|evm.model.AC_000179.1.189 Q17QE2 LMCD1_BOVIN 100.000 0.994505 1.00275 LMCD1 - LIM and cysteine-rich domains protein 1 - Bos taurus (Bovine) - LMCD1 gene Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway (By similarity). Taurus_UMD|evm.model.AC_000179.1.192 Q5RDQ8 GRM7_PONAB 98.795 0.427083 0.208243 GRM7 - Metabotropic glutamate receptor 7 precursor - Pongo abelii (Sumatran orangutan) - GRM7 gene G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (By similarity). Taurus_UMD|evm.model.AC_000179.1.193 Q14831 GRM7_HUMAN 99.355 0.919643 0.367213 GRM7 - Metabotropic glutamate receptor 7 precursor - Homo sapiens (Human) - GRM7 gene G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (PubMed:33500274). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (PubMed:9473604). Taurus_UMD|evm.model.AC_000179.1.194 Q68ED2 GRM7_MOUSE 99.099 0.823821 0.440437 Grm7 - Metabotropic glutamate receptor 7 precursor - Mus musculus (Mouse) - Grm7 gene G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (By similarity). Taurus_UMD|evm.model.AC_000179.1.195 P35400 GRM7_RAT 98.276 0.961111 0.196721 Grm7 - Metabotropic glutamate receptor 7 precursor - Rattus norvegicus (Rat) - Grm7 gene G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits. Taurus_UMD|evm.model.AC_000179.1.197 Q92611 EDEM1_HUMAN 94.985 0.996965 1.00304 EDEM1 - ER degradation-enhancing alpha-mannosidase-like protein 1 - Homo sapiens (Human) - EDEM1 gene Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2. Taurus_UMD|evm.model.AC_000179.1.198 Q66HA6 ARL8B_RAT 100.000 0.748988 1.32796 Arl8b - ADP-ribosylation factor-like protein 8B - Rattus norvegicus (Rat) - Arl8b gene Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation. Along with its effectors, orchestrates lysosomal transport and fusion. Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes. Required for lysosomal and cytolytic granule exocytosis. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense. Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes. Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing. Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes (By similarity). Involved in the process of MHC II presentation. Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes (By similarity). May play a role in chromosome segregation (By similarity). Taurus_UMD|evm.model.AC_000179.1.199 Q5EA15 BHE40_BOVIN 100.000 0.995157 1.00243 BHLHE40 - Class E basic helix-loop-helix protein 40 - Bos taurus (Bovine) - BHLHE40 gene Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (By similarity). Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-ARNTL/BMAL1 complex (By similarity). Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (By similarity). Taurus_UMD|evm.model.AC_000179.1.200 Q9TU34 ITPR1_BOVIN 98.968 0.999263 1.00221 ITPR1 - Inositol 1,4,5-trisphosphate receptor type 1 - Bos taurus (Bovine) - ITPR1 gene Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. Taurus_UMD|evm.model.AC_000179.1.201 Q0P5L5 SUMF1_BOVIN 100.000 0.994667 1.00267 SUMF1 - Formylglycine-generating enzyme precursor - Bos taurus (Bovine) - SUMF1 gene Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE. Taurus_UMD|evm.model.AC_000179.1.202 P60897 SEM1_MOUSE 100.000 0.971831 1.01429 Sem1 - 26S proteasome complex subunit SEM1 - Mus musculus (Mouse) - Sem1 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells. Taurus_UMD|evm.model.AC_000179.1.203 Q0VD24 SETMR_BOVIN 100.000 0.993485 1.00327 SETMAR - Histone-lysine N-methyltransferase SETMAR - Bos taurus (Bovine) - SETMAR gene Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Taurus_UMD|evm.model.AC_000179.1.204 Q9YH06 HMGB1_CHICK 76.471 0.267241 0.539535 HMGB1 - High mobility group protein B1 - Gallus gallus (Chicken) - HMGB1 gene Multifunctional redox sensitive protein with various roles in different cellular compartments. Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Can restructure the canonical nucleosome. Proposed to be an universal biosensor for nucleic acids. May promote inflammatory response to sterile and infectious signals and may be involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm may function as sensor and/or chaperone for immunogenic nucleic acids, and mediate autophagy. May act as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Taurus_UMD|evm.model.AC_000179.1.205 A0N0X6 LRRN1_BOVIN 100.000 0.997211 1.0014 LRRN1 - Leucine-rich repeat neuronal protein 1 precursor - Bos taurus (Bovine) - LRRN1 gene extracellular matrix, extracellular space Taurus_UMD|evm.model.AC_000179.1.206 Q0P564 CRBN_BOVIN 100.000 0.995506 1.00225 CRBN - Protein cereblon - Bos taurus (Bovine) - CRBN gene Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (By similarity). May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity). Taurus_UMD|evm.model.AC_000179.1.207 Q8K1J6 TRNT1_MOUSE 91.475 0.995402 1.0023 Trnt1 - CCA tRNA nucleotidyltransferase 1, mitochondrial precursor - Mus musculus (Mouse) - Trnt1 gene Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. Taurus_UMD|evm.model.AC_000179.1.208 Q01344 IL5RA_HUMAN 74.745 0.946731 0.983333 IL5RA - Interleukin-5 receptor subunit alpha precursor - Homo sapiens (Human) - IL5RA gene This is the receptor for interleukin-5. The alpha chain binds to IL5. Taurus_UMD|evm.model.AC_000179.1.210 Q9UQ52 CNTN6_HUMAN 64.678 0.887922 0.893969 CNTN6 - Contactin-6 precursor - Homo sapiens (Human) - CNTN6 gene Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity). Taurus_UMD|evm.model.AC_000179.1.211 Q6TY21 EPA2B_XENLA 70.297 0.411523 1.11468 Pabpn1l-b - Embryonic polyadenylate-binding protein 2-B - Xenopus laevis (African clawed frog) - Pabpn1l-b gene Binds the poly(A) tail of mRNA. Unable to interact with the cap-binding complex and is therefore unlikely to be involved in translation initiation. Taurus_UMD|evm.model.AC_000179.1.212 O00533 NCHL1_HUMAN 88.327 0.998369 1.0149 CHL1 - Neural cell adhesion molecule L1-like protein precursor - Homo sapiens (Human) - CHL1 gene Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). Taurus_UMD|evm.model.AC_000179.1.213 Q9P232 CNTN3_HUMAN 89.016 0.537888 0.783074 CNTN3 - Contactin-3 precursor - Homo sapiens (Human) - CNTN3 gene Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity). Taurus_UMD|evm.model.AC_000179.1.215 Q9UPQ7 PZRN3_HUMAN 92.804 0.998117 0.996248 PDZRN3 - E3 ubiquitin-protein ligase PDZRN3 - Homo sapiens (Human) - PDZRN3 gene E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. Taurus_UMD|evm.model.AC_000179.1.216 Q9NY27 PP4R2_HUMAN 92.326 0.995157 0.990408 PPP4R2 - Serine/threonine-protein phosphatase 4 regulatory subunit 2 - Homo sapiens (Human) - PPP4R2 gene Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. Taurus_UMD|evm.model.AC_000179.1.217 A0PJZ3 GXLT2_HUMAN 96.338 0.934037 0.85553 GXYLT2 - Glucoside xylosyltransferase 2 - Homo sapiens (Human) - GXYLT2 gene Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose. Taurus_UMD|evm.model.AC_000179.1.218 Q3MHH1 SHQ1_BOVIN 100.000 0.996552 1.00173 SHQ1 - Protein SHQ1 homolog - Bos taurus (Bovine) - SHQ1 gene Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. Taurus_UMD|evm.model.AC_000179.1.221 Q8N488 RYBP_HUMAN 99.539 0.990826 0.95614 RYBP - RING1 and YY1-binding protein - Homo sapiens (Human) - RYBP gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911). Taurus_UMD|evm.model.AC_000179.1.226 O54897 GPR27_MOUSE 87.654 0.98773 0.430079 Gpr27 - Probable G-protein coupled receptor 27 - Mus musculus (Mouse) - Gpr27 gene Orphan receptor. Possible candidate for amine-like G-protein coupled receptor (By similarity). Taurus_UMD|evm.model.AC_000179.1.227 Q8N5X7 IF4E3_HUMAN 98.795 0.816832 0.901786 EIF4E3 - Eukaryotic translation initiation factor 4E type 3 - Homo sapiens (Human) - EIF4E3 gene Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity). Taurus_UMD|evm.model.AC_000179.1.229 A4IFD2 FOXP1_BOVIN 99.838 0.923423 0.988131 FOXP1 - Forkhead box protein P1 - Bos taurus (Bovine) - FOXP1 gene Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18. Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling (By similarity). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (By similarity). Taurus_UMD|evm.model.AC_000179.1.230 A0A1B0GVS7 MDFI2_HUMAN 81.287 0.982456 0.904762 MDFIC2 - MyoD family inhibitor domain-containing protein 2 - Homo sapiens (Human) - MDFIC2 gene Taurus_UMD|evm.model.AC_000179.1.231 O75030 MITF_HUMAN 96.578 0.996161 0.990494 MITF - Microphthalmia-associated transcription factor - Homo sapiens (Human) - MITF gene Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. Taurus_UMD|evm.model.AC_000179.1.232 Q10126 YSM6_CAEEL 26.667 0.875 0.602151 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000179.1.233 Q8WUD1 RAB2B_HUMAN 67.164 0.977778 0.625 RAB2B - Ras-related protein Rab-2B - Homo sapiens (Human) - RAB2B gene Required for protein transport from the endoplasmic reticulum to the Golgi complex. Taurus_UMD|evm.model.AC_000179.1.234 Q9Y2L6 FRM4B_HUMAN 93.913 0.998069 1.00193 FRMD4B - FERM domain-containing protein 4B - Homo sapiens (Human) - FRMD4B gene Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. Taurus_UMD|evm.model.AC_000179.1.235 Q0VAK6 LMOD3_HUMAN 83.957 0.984155 1.01429 LMOD3 - Leiomodin-3 - Homo sapiens (Human) - LMOD3 gene Essential for the organization of sarcomeric actin thin filaments in skeletal muscle (PubMed:25250574). Increases the rate of actin polymerization (PubMed:25250574). Taurus_UMD|evm.model.AC_000179.1.236 Q5E9M1 PRAF3_BOVIN 100.000 0.989418 1.00532 ARL6IP5 - PRA1 family protein 3 - Bos taurus (Bovine) - ARL6IP5 gene Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum. Taurus_UMD|evm.model.AC_000179.1.237 Q8TBC4 UBA3_HUMAN 98.920 0.99569 1.00216 UBA3 - NEDD8-activating enzyme E1 catalytic subunit - Homo sapiens (Human) - UBA3 gene Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. Taurus_UMD|evm.model.AC_000179.1.238 P82094 TMF1_HUMAN 92.589 0.99817 1 TMF1 - TATA element modulatory factor - Homo sapiens (Human) - TMF1 gene Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). Taurus_UMD|evm.model.AC_000179.1.239 A0JND3 EOGT_BOVIN 100.000 0.996212 1.0019 EOGT - EGF domain-specific O-linked N-acetylglucosamine transferase precursor - Bos taurus (Bovine) - EOGT gene Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Taurus_UMD|evm.model.AC_000179.1.240 Q9N0D3 TAFA4_MACFA 94.245 0.741935 1.32857 TAFA4 - Chemokine-like protein TAFA-4 precursor - Macaca fascicularis (Crab-eating macaque) - TAFA4 gene Modulates injury-induced and chemical pain hypersensitivity. Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release. Taurus_UMD|evm.model.AC_000179.1.241 Q7TPG8 TAFA1_MOUSE 100.000 0.839286 0.842105 Tafa1 - Chemokine-like protein TAFA-1 precursor - Mus musculus (Mouse) - Tafa1 gene Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Taurus_UMD|evm.model.AC_000179.1.243 Q8NHQ8 RASF8_HUMAN 93.137 0.89823 0.539379 RASSF8 - Ras association domain-containing protein 8 - Homo sapiens (Human) - RASSF8 gene Taurus_UMD|evm.model.AC_000179.1.244 Q3MHX5 SUCB2_BOVIN 100.000 0.995381 1.00231 SUCLG2 - Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial precursor - Bos taurus (Bovine) - SUCLG2 gene GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Taurus_UMD|evm.model.AC_000179.1.245 Q8NFY9 KBTB8_HUMAN 98.170 0.996678 1.00166 KBTBD8 - Kelch repeat and BTB domain-containing protein 8 - Homo sapiens (Human) - KBTBD8 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Taurus_UMD|evm.model.AC_000179.1.247 Q96JA1 LRIG1_HUMAN 82.188 0.998167 0.99817 LRIG1 - Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor - Homo sapiens (Human) - LRIG1 gene Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. Taurus_UMD|evm.model.AC_000179.1.248 A6QR09 SAMC_BOVIN 99.635 0.992727 1.00365 SLC25A26 - S-adenosylmethionine mitochondrial carrier protein - Bos taurus (Bovine) - SLC25A26 gene Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria (By similarity). Taurus_UMD|evm.model.AC_000179.1.249 Q920A7 AFG31_MOUSE 77.848 0.844086 0.235741 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Taurus_UMD|evm.model.AC_000179.1.250 Q96QZ7 MAGI1_HUMAN 93.997 0.998634 0.490946 MAGI1 - Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 - Homo sapiens (Human) - MAGI1 gene May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). Taurus_UMD|evm.model.AC_000179.1.252 Q2TBN4 MED28_BOVIN 92.105 0.877907 0.966292 MED28 - Mediator of RNA polymerase II transcription subunit 28 - Bos taurus (Bovine) - MED28 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways (By similarity). Taurus_UMD|evm.model.AC_000179.1.254 Q9P2N4 ATS9_HUMAN 85.808 0.99877 0.84031 ADAMTS9 - A disintegrin and metalloproteinase with thrombospondin motifs 9 precursor - Homo sapiens (Human) - ADAMTS9 gene Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. Taurus_UMD|evm.model.AC_000179.1.256 Q7Z3G6 PRIC2_HUMAN 95.379 0.9547 1.04621 PRICKLE2 - Prickle-like protein 2 precursor - Homo sapiens (Human) - PRICKLE2 gene cytoplasm, Wnt signaling pathway, planar cell polarity pathway Taurus_UMD|evm.model.AC_000179.1.257 Q3T0B2 PSMD6_BOVIN 99.743 0.994872 1.00257 PSMD6 - 26S proteasome non-ATPase regulatory subunit 6 - Bos taurus (Bovine) - PSMD6 gene Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Taurus_UMD|evm.model.AC_000179.1.258 O15265 ATX7_HUMAN 88.552 0.91519 0.88565 ATXN7 - Ataxin-7 - Homo sapiens (Human) - ATXN7 gene Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization. Taurus_UMD|evm.model.AC_000179.1.259 O15265 ATX7_HUMAN 80.909 0.951923 0.116592 ATXN7 - Ataxin-7 - Homo sapiens (Human) - ATXN7 gene Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization. Taurus_UMD|evm.model.AC_000179.1.260 Q6I9Y2 THOC7_HUMAN 99.495 0.9801 0.985294 THOC7 - THO complex subunit 7 homolog - Homo sapiens (Human) - THOC7 gene Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Taurus_UMD|evm.model.AC_000179.1.261 Q96BT1 CC049_HUMAN 66.783 0.963235 0.931507 C3orf49 - Putative uncharacterized protein C3orf49 - Homo sapiens (Human) - C3orf49 gene Taurus_UMD|evm.model.AC_000179.1.262 Q8BL00 CDHR3_MOUSE 30.172 0.958217 0.43201 Cdhr3 - Cadherin-related family member 3 precursor - Mus musculus (Mouse) - Cdhr3 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Taurus_UMD|evm.model.AC_000179.1.263 Q0P561 SNTAN_BOVIN 92.381 0.534759 1.27211 SNTN - Sentan - Bos taurus (Bovine) - SNTN gene May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules. Taurus_UMD|evm.model.AC_000179.1.264 Q8TBG9 SYNPR_HUMAN 93.962 0.992481 1.00377 SYNPR - Synaptoporin - Homo sapiens (Human) - SYNPR gene Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity). Taurus_UMD|evm.model.AC_000179.1.265 Q80TJ1 CAPS1_MOUSE 96.703 0.891089 0.0745387 Cadps - Calcium-dependent secretion activator 1 - Mus musculus (Mouse) - Cadps gene Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). Taurus_UMD|evm.model.AC_000179.1.266 Q62717 CAPS1_RAT 95.703 0.956969 0.829325 Cadps - Calcium-dependent secretion activator 1 - Rattus norvegicus (Rat) - Cadps gene Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering. Taurus_UMD|evm.model.AC_000179.1.267 Q2VWH6 FEZF2_BOVIN 100.000 0.995643 1.00218 FEZF2 - Fez family zinc finger protein 2 - Bos taurus (Bovine) - FEZF2 gene Transcription repressor. Binds to 5'GCAG-3' core sequence. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons (By similarity). May be responsible for mastitis resistance and innate immunity. Taurus_UMD|evm.model.AC_000179.1.268 Q29S20 CC014_BOVIN 100.000 0.984496 1.00781 Uncharacterized protein C3orf14 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000179.1.269 P23470 PTPRG_HUMAN 90.073 0.996686 0.835294 PTPRG - Receptor-type tyrosine-protein phosphatase gamma precursor - Homo sapiens (Human) - PTPRG gene Possesses tyrosine phosphatase activity. Taurus_UMD|evm.model.AC_000179.1.270 P23470 PTPRG_HUMAN 84.375 0.814103 0.107958 PTPRG - Receptor-type tyrosine-protein phosphatase gamma precursor - Homo sapiens (Human) - PTPRG gene Possesses tyrosine phosphatase activity. Taurus_UMD|evm.model.AC_000179.1.272 Q9NUJ7 PLCX1_HUMAN 50.000 0.982394 0.879257 PLCXD1 - PI-PLC X domain-containing protein 1 - Homo sapiens (Human) - PLCXD1 gene Taurus_UMD|evm.model.AC_000179.1.273 Q13796 SHRM2_HUMAN 65.591 0.884615 0.0643564 SHROOM2 - Protein Shroom2 - Homo sapiens (Human) - SHROOM2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). Taurus_UMD|evm.model.AC_000179.1.275 Q98936 PTPRG_CHICK 73.333 0.178862 0.172996 PTPRG - Receptor-type tyrosine-protein phosphatase gamma precursor - Gallus gallus (Chicken) - PTPRG gene Taurus_UMD|evm.model.AC_000179.1.277 P0CG00 ZSA5D_HUMAN 37.681 0.581197 0.235412 ZSCAN5DP - Putative zinc finger and SCAN domain-containing protein 5D - Homo sapiens (Human) - ZSCAN5DP gene DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000179.1.278 Q1KZG4 FHIT_BOVIN 100.000 0.980198 0.677852 FHIT - Bis(5'-adenosyl)-triphosphatase - Bos taurus (Bovine) - FHIT gene Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity. Functions as tumor suppressor (By similarity). Taurus_UMD|evm.model.AC_000179.1.279 Q95JY0 CF20D_MACFA 90.446 0.226415 1 CFAP20DC - Protein CFAP20DC - Macaca fascicularis (Crab-eating macaque) - CFAP20DC gene Taurus_UMD|evm.model.AC_000179.1.282 Q5NVP3 F107A_PONAB 95.833 0.82659 1.20139 FAM107A - Actin-associated protein FAM107A - Pongo abelii (Sumatran orangutan) - FAM107A gene Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner. May play a role in tumor development (By similarity). Taurus_UMD|evm.model.AC_000179.1.283 Q99424 ACOX2_HUMAN 80.147 0.994143 1.00294 ACOX2 - Peroxisomal acyl-coenzyme A oxidase 2 - Homo sapiens (Human) - ACOX2 gene Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids (PubMed:27884763). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity). Taurus_UMD|evm.model.AC_000179.1.284 Q8NC69 KCTD6_HUMAN 99.578 0.991597 1.00422 KCTD6 - BTB/POZ domain-containing protein KCTD6 - Homo sapiens (Human) - KCTD6 gene Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887). Taurus_UMD|evm.model.AC_000179.1.285 P11966 ODPB_BOVIN 100.000 0.994444 1.00279 PDHB - Pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor - Bos taurus (Bovine) - PDHB gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Taurus_UMD|evm.model.AC_000179.1.286 Q7Z7A4 PXK_HUMAN 96.718 0.996552 1.00346 PXK - PX domain-containing protein kinase-like protein - Homo sapiens (Human) - PXK gene Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. Taurus_UMD|evm.model.AC_000179.1.287 P86397 HTD2_HUMAN 84.524 0.988166 1.00595 HTD2 - Hydroxyacyl-thioester dehydratase type 2, mitochondrial precursor - Homo sapiens (Human) - HTD2 gene Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis. Taurus_UMD|evm.model.AC_000179.1.288 Q5RB79 RPP14_PONAB 92.742 0.984 1.00806 RPP14 - Ribonuclease P protein subunit p14 - Pongo abelii (Sumatran orangutan) - RPP14 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Taurus_UMD|evm.model.AC_000179.1.290 Q1LZ86 ABHD6_BOVIN 100.000 0.994083 1.00297 ABHD6 - Monoacylglycerol lipase ABHD6 - Bos taurus (Bovine) - ABHD6 gene Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (By similarity). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (By similarity). Taurus_UMD|evm.model.AC_000179.1.291 O89107 DNSL3_RAT 85.965 0.928105 0.987097 Dnase1l3 - Deoxyribonuclease gamma precursor - Rattus norvegicus (Rat) - Dnase1l3 gene Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (PubMed:7957253). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (By similarity). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). Taurus_UMD|evm.model.AC_000179.1.292 A0A1B0GUX0 VAFNB_HUMAN 49.206 0.28972 1.21591 ATP6V1FNB - Protein ATP6V1FNB - Homo sapiens (Human) - ATP6V1FNB gene Taurus_UMD|evm.model.AC_000179.1.293 Q9MZD2 FLNB_RABIT 97.945 0.112834 8.77211 FLNB - Filamin-B - Oryctolagus cuniculus (Rabbit) - FLNB gene Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton (By similarity). Taurus_UMD|evm.model.AC_000179.1.294 Q14BN4 SLMAP_HUMAN 93.421 0.989324 1.01812 SLMAP - Sarcolemmal membrane-associated protein - Homo sapiens (Human) - SLMAP gene May play a role during myoblast fusion. Taurus_UMD|evm.model.AC_000179.1.295 Q8IWF6 DEN6A_HUMAN 95.724 0.996716 1.00164 DENND6A - Protein DENND6A - Homo sapiens (Human) - DENND6A gene Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes. Taurus_UMD|evm.model.AC_000179.1.296 Q3SZF2 ARF4_BOVIN 100.000 0.98895 1.00556 ARF4 - ADP-ribosylation factor 4 - Bos taurus (Bovine) - ARF4 gene GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). Taurus_UMD|evm.model.AC_000179.1.297 Q08DF7 PDE12_BOVIN 100.000 0.996721 1.00164 PDE12 - 2',5'-phosphodiesterase 12 precursor - Bos taurus (Bovine) - PDE12 gene Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells. Taurus_UMD|evm.model.AC_000179.1.298 Q6ZR08 DYH12_HUMAN 94.370 0.163628 1.47251 DNAH12 - Dynein axonemal heavy chain 12 - Homo sapiens (Human) - DNAH12 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Taurus_UMD|evm.model.AC_000179.1.299 Q9UKG1 DP13A_HUMAN 97.743 0.997179 1 APPL1 - DCC-interacting protein 13-alpha - Homo sapiens (Human) - APPL1 gene Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:26073777, PubMed:19661063, PubMed:10490823). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:26073777, PubMed:19661063, PubMed:24879834). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). Taurus_UMD|evm.model.AC_000179.1.300 Q8NFM7 I17RD_HUMAN 89.730 0.997294 1 IL17RD - Interleukin-17 receptor D precursor - Homo sapiens (Human) - IL17RD gene Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation (PubMed:12958313, PubMed:12807873). Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK (PubMed:15239952). Mediates JNK activation and may be involved in apoptosis (By similarity). May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity). Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). Taurus_UMD|evm.model.AC_000179.1.301 Q9NR81 ARHG3_HUMAN 96.579 0.896926 1.05133 ARHGEF3 - Rho guanine nucleotide exchange factor 3 - Homo sapiens (Human) - ARHGEF3 gene Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. Taurus_UMD|evm.model.AC_000179.1.302 Q9UK61 TASOR_HUMAN 88.737 0.945136 1.05868 TASOR - Protein TASOR - Homo sapiens (Human) - TASOR gene Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). Taurus_UMD|evm.model.AC_000179.1.303 F1PZQ5 CCD66_CANLF 76.390 0.96319 1.0642 CCDC66 - Coiled-coil domain-containing protein 66 - Canis lupus familiaris (Dog) - CCDC66 gene Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (By similarity). Plays a role in retina morphogenesis and/or homeostasis (PubMed:19777273). Taurus_UMD|evm.model.AC_000179.1.304 O15083 ERC2_HUMAN 98.955 0.997904 0.996865 ERC2 - ERC protein 2 - Homo sapiens (Human) - ERC2 gene Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ. Taurus_UMD|evm.model.AC_000179.1.305 Q27Q52 WNT5A_RABIT 98.421 0.994751 1.00263 WNT5A - Protein Wnt-5a precursor - Oryctolagus cuniculus (Rabbit) - WNT5A gene Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur (PubMed:16754689). Inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells (By similarity). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle (By similarity). Inhibits type II collagen expression in chondrocytes (PubMed:16754689). Taurus_UMD|evm.model.AC_000179.1.308 Q9Z1L5 CA2D3_MOUSE 90.749 0.585938 0.351971 Cacna2d3 - Voltage-dependent calcium channel subunit alpha-2/delta-3 precursor - Mus musculus (Mouse) - Cacna2d3 gene The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G). Taurus_UMD|evm.model.AC_000179.1.309 Q9HBL6 LRTM1_HUMAN 76.119 0.994048 0.973913 LRTM1 - Leucine-rich repeat and transmembrane domain-containing protein 1 precursor - Homo sapiens (Human) - LRTM1 gene heparin binding, Roundabout binding, axon guidance, negative chemotaxis Taurus_UMD|evm.model.AC_000179.1.310 Q8CFG5 CA2D3_RAT 99.052 0.919214 0.42212 Cacna2d3 - Voltage-dependent calcium channel subunit alpha-2/delta-3 precursor - Rattus norvegicus (Rat) - Cacna2d3 gene The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). Taurus_UMD|evm.model.AC_000179.1.312 Q9Z1L5 CA2D3_MOUSE 98.457 0.843342 0.351054 Cacna2d3 - Voltage-dependent calcium channel subunit alpha-2/delta-3 precursor - Mus musculus (Mouse) - Cacna2d3 gene The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G). Taurus_UMD|evm.model.AC_000179.1.313 Q8CFG5 CA2D3_RAT 93.220 0.282927 0.18894 Cacna2d3 - Voltage-dependent calcium channel subunit alpha-2/delta-3 precursor - Rattus norvegicus (Rat) - Cacna2d3 gene The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). Taurus_UMD|evm.model.AC_000179.1.314 P68105 EF1A1_RABIT 91.885 0.995098 0.883117 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000179.1.315 Q1LZF2 ARP8_BOVIN 100.000 0.9968 1.0016 ACTR8 - Actin-related protein 8 - Bos taurus (Bovine) - ACTR8 gene Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity). Taurus_UMD|evm.model.AC_000179.1.316 Q9NRM6 I17RB_HUMAN 78.004 0.973948 0.994024 IL17RB - Interleukin-17 receptor B precursor - Homo sapiens (Human) - IL17RB gene Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells. Taurus_UMD|evm.model.AC_000179.1.317 Q8NE62 CHDH_HUMAN 82.353 0.996364 0.925926 CHDH - Choline dehydrogenase, mitochondrial precursor - Homo sapiens (Human) - CHDH gene mitochondrial inner membrane, choline dehydrogenase activity, oxidoreductase activity, choline catabolic process Taurus_UMD|evm.model.AC_000179.1.318 Q99244 CAC1D_MESAU 97.055 0.738318 1.32919 CACNA1D - Voltage-dependent L-type calcium channel subunit alpha-1D - Mesocricetus auratus (Golden hamster) - CACNA1D gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Taurus_UMD|evm.model.AC_000179.1.319 O41515 MLP3B_BOVIN 65.600 0.975904 0.664 MAP1LC3B - Microtubule-associated proteins 1A/1B light chain 3B precursor - Bos taurus (Bovine) - MAP1LC3B gene Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Taurus_UMD|evm.model.AC_000179.1.320 Q9BSY4 CHCH5_HUMAN 86.364 0.981982 1.00909 CHCHD5 - Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 - Homo sapiens (Human) - CHCHD5 gene mitochondrion Taurus_UMD|evm.model.AC_000179.1.321 I3LHS8 DCP1A_PIG 89.310 0.996422 0.963793 DCP1A - mRNA-decapping enzyme 1A - Sus scrofa (Pig) - DCP1A gene Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Taurus_UMD|evm.model.AC_000179.1.322 Q6B855 TKT_BOVIN 99.197 0.996795 1.00161 TKT - Transketolase - Bos taurus (Bovine) - TKT gene Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Taurus_UMD|evm.model.AC_000179.1.323 Q5PU49 KPCD_CANLF 91.407 0.995556 1.00148 PRKCD - Protein kinase C delta type - Canis lupus familiaris (Dog) - PRKCD gene Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (By similarity). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion. Phosphorylates ELAVL1 in response to angiotensin-2 treatment (By similarity). Phosphorylates mitochondrial phospolipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (By similarity). Phosphorylates SMPD1 which induces SMPD1 secretion (By similarity). Taurus_UMD|evm.model.AC_000179.1.324 Q96AA3 RFT1_HUMAN 90.943 0.99631 1.00185 RFT1 - Protein RFT1 homolog - Homo sapiens (Human) - RFT1 gene May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane. Taurus_UMD|evm.model.AC_000179.1.326 Q9UHJ3 SMBT1_HUMAN 96.536 0.997691 1 SFMBT1 - Scm-like with four MBT domains protein 1 - Homo sapiens (Human) - SFMBT1 gene Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis. Taurus_UMD|evm.model.AC_000179.1.327 Q86TL2 STIMA_HUMAN 97.959 0.99322 1.0034 STIMATE - Store-operated calcium entry regulator STIMATE - Homo sapiens (Human) - STIMATE gene Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574). Taurus_UMD|evm.model.AC_000179.1.329 Q32KU9 MSTN1_BOVIN 96.341 0.931034 1.06098 MUSTN1 - Musculoskeletal embryonic nuclear protein 1 - Bos taurus (Bovine) - MUSTN1 gene May be involved in the development and regeneration of the musculoskeletal system. Taurus_UMD|evm.model.AC_000179.1.330 Q3T052 ITIH4_BOVIN 99.782 0.997819 1.00109 ITIH4 - Inter-alpha-trypsin inhibitor heavy chain H4 precursor - Bos taurus (Bovine) - ITIH4 gene Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. Taurus_UMD|evm.model.AC_000179.1.331 P56652 ITIH3_BOVIN 100.000 0.997758 1.00112 ITIH3 - Inter-alpha-trypsin inhibitor heavy chain H3 precursor - Bos taurus (Bovine) - ITIH3 gene May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Taurus_UMD|evm.model.AC_000179.1.332 Q0VCM5 ITIH1_BOVIN 99.890 0.997795 1.0011 ITIH1 - Inter-alpha-trypsin inhibitor heavy chain H1 precursor - Bos taurus (Bovine) - ITIH1 gene May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Taurus_UMD|evm.model.AC_000179.1.333 P51957 NEK4_HUMAN 77.461 0.997462 0.93698 NEK4 - Serine/threonine-protein kinase Nek4 - Homo sapiens (Human) - NEK4 gene Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. Taurus_UMD|evm.model.AC_000179.1.334 Q3T134 SPCS1_BOVIN 100.000 0.265789 3.72549 SPCS1 - Signal peptidase complex subunit 1 - Bos taurus (Bovine) - SPCS1 gene Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Taurus_UMD|evm.model.AC_000179.1.335 Q5E9E7 GL8D1_BOVIN 100.000 0.994624 1.0027 GLT8D1 - Glycosyltransferase 8 domain-containing protein 1 - Bos taurus (Bovine) - GLT8D1 gene Golgi apparatus Taurus_UMD|evm.model.AC_000179.1.336 Q9BVP2 GNL3_HUMAN 78.403 0.99635 0.998179 GNL3 - Guanine nucleotide-binding protein-like 3 - Homo sapiens (Human) - GNL3 gene May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity). Taurus_UMD|evm.model.AC_000179.1.337 Q86U86 PB1_HUMAN 98.638 0.998816 1 PBRM1 - Protein polybromo-1 - Homo sapiens (Human) - PBRM1 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. Taurus_UMD|evm.model.AC_000179.1.338 Q8WVI0 SMIM4_HUMAN 92.754 0.839506 1.15714 SMIM4 - Small integral membrane protein 4 - Homo sapiens (Human) - SMIM4 gene Taurus_UMD|evm.model.AC_000179.1.339 Q9H857 NT5D2_HUMAN 96.901 0.864043 1.075 NT5DC2 - 5'-nucleotidase domain-containing protein 2 - Homo sapiens (Human) - NT5DC2 gene 5'-nucleotidase activity Taurus_UMD|evm.model.AC_000179.1.340 Q9NY15 STAB1_HUMAN 84.215 0.999221 0.999611 STAB1 - Stabilin-1 precursor - Homo sapiens (Human) - STAB1 gene Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system. Taurus_UMD|evm.model.AC_000179.1.341 Q9Y2I1 NISCH_HUMAN 90.383 0.991299 0.993351 NISCH - Nischarin - Homo sapiens (Human) - NISCH gene Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures. Taurus_UMD|evm.model.AC_000179.1.342 P63317 TNNC1_PIG 100.000 0.987654 1.00621 TNNC1 - Troponin C, slow skeletal and cardiac muscles - Sus scrofa (Pig) - TNNC1 gene Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Taurus_UMD|evm.model.AC_000179.1.343 Q9NS98 SEM3G_HUMAN 86.154 0.997406 0.985934 SEMA3G - Semaphorin-3G precursor - Homo sapiens (Human) - SEMA3G gene Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity). Taurus_UMD|evm.model.AC_000179.1.344 Q9BWX1 PHF7_HUMAN 84.856 0.994792 1.00787 PHF7 - PHD finger protein 7 - Homo sapiens (Human) - PHF7 gene May play a role in spermatogenesis. Taurus_UMD|evm.model.AC_000179.1.345 A2VDM8 BAP1_BOVIN 91.262 0.982265 1.03094 BAP1 - Ubiquitin carboxyl-terminal hydrolase BAP1 - Bos taurus (Bovine) - BAP1 gene Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor. Taurus_UMD|evm.model.AC_000179.1.346 Q9P2D7 DYH1_HUMAN 85.906 0.99904 0.977022 DNAH1 - Dynein axonemal heavy chain 1 - Homo sapiens (Human) - DNAH1 gene Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (PubMed:24360805). Taurus_UMD|evm.model.AC_000179.1.348 Q2KJF7 GLCTK_BOVIN 93.117 0.995902 0.933078 GLYCTK - Glycerate kinase - Bos taurus (Bovine) - GLYCTK gene cytoplasm, glycerate kinase activity, protein phosphorylation Taurus_UMD|evm.model.AC_000179.1.349 Q8BFQ4 WDR82_MOUSE 100.000 0.993631 1.00319 Wdr82 - WD repeat-containing protein 82 - Mus musculus (Mouse) - Wdr82 gene Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Possible role in telomere length maintenance and in mRNA processing (By similarity). Taurus_UMD|evm.model.AC_000179.1.350 Q96MI6 PPM1M_HUMAN 92.857 0.587822 1.58148 PPM1M - Protein phosphatase 1M - Homo sapiens (Human) - PPM1M gene nucleus, manganese ion binding, protein serine/threonine phosphatase activity, protein dephosphorylation Taurus_UMD|evm.model.AC_000179.1.351 Q6IBS0 TWF2_HUMAN 95.129 0.994286 1.00287 TWF2 - Twinfilin-2 - Homo sapiens (Human) - TWF2 gene Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). Taurus_UMD|evm.model.AC_000179.1.352 Q5I2M5 TLR9_BOVIN 99.606 0.963878 1.02235 TLR9 - Toll-like receptor 9 precursor - Bos taurus (Bovine) - TLR9 gene Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). Taurus_UMD|evm.model.AC_000179.1.353 A6QLI6 HEM1_BOVIN 100.000 0.920228 1.08501 ALAS1 - 5-aminolevulinate synthase, nonspecific, mitochondrial precursor - Bos taurus (Bovine) - ALAS1 gene mitochondrion, 5-aminolevulinate synthase activity, erythrocyte development, heme biosynthetic process, hemoglobin biosynthetic process, response to hypoxia Taurus_UMD|evm.model.AC_000179.1.354 Q2TBP4 POC1A_BOVIN 100.000 0.995098 1.00246 POC1A - POC1 centriolar protein homolog A - Bos taurus (Bovine) - POC1A gene Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation (By similarity). Taurus_UMD|evm.model.AC_000179.1.355 Q63340 DUS7_RAT 99.728 0.99458 0.880668 Dusp7 - Dual specificity protein phosphatase 7 - Rattus norvegicus (Rat) - Dusp7 gene Dual specificity protein phosphatase (By similarity). Shows high activity towards MAPK1/ERK2 (By similarity). Also has lower activity towards MAPK14 and MAPK8 (By similarity). In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex. Taurus_UMD|evm.model.AC_000179.1.356 Q58DW3 RL29_BOVIN 100.000 0.986928 1.00658 RPL29 - 60S ribosomal protein L29 - Bos taurus (Bovine) - RPL29 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000179.1.357 P37111 ACY1_PIG 88.971 0.99511 1.00491 ACY1 - Aminoacylase-1 - Sus scrofa (Pig) - ACY1 gene Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). Taurus_UMD|evm.model.AC_000179.1.358 Q9BUJ0 ABHEA_HUMAN 85.597 0.987755 0.904059 ABHD14A - Protein ABHD14A - Homo sapiens (Human) - ABHD14A gene Possible role in granule neuron development. Taurus_UMD|evm.model.AC_000179.1.359 A7YY28 ABHEB_BOVIN 100.000 0.990521 1.00476 ABHD14B - Protein ABHD14B - Bos taurus (Bovine) - ABHD14B gene Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription (By similarity). Taurus_UMD|evm.model.AC_000179.1.361 Q0VCU0 PCBP4_BOVIN 100.000 0.993884 0.811414 PCBP4 - Poly(rC)-binding protein 4 - Bos taurus (Bovine) - PCBP4 gene Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Taurus_UMD|evm.model.AC_000179.1.362 Q9BZJ7 GPR62_HUMAN 88.764 0.975275 0.98913 GPR62 - G-protein coupled receptor 62 - Homo sapiens (Human) - GPR62 gene Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). Taurus_UMD|evm.model.AC_000179.1.363 Q9Y6F1 PARP3_HUMAN 67.917 0.940828 0.95122 PARP3 - Protein mono-ADP-ribosyltransferase PARP3 - Homo sapiens (Human) - PARP3 gene Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:16924674, PubMed:20064938, PubMed:21211721, PubMed:21270334, PubMed:25043379, PubMed:24598253). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (PubMed:20064938, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721). Cooperates with the XRRC6-XRCC5 (Ku70-Ku80) heterodimer to limit end-resection thereby promoting accurate NHEJ (PubMed:24598253). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRRC5 and XRCC6 (PubMed:16924674, PubMed:24598253). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:16924674, PubMed:21211721, PubMed:21270334). May link the DNA damage surveillance network to the mitotic fidelity checkpoint (PubMed:16924674). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (PubMed:29361132, PubMed:29520010). Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (By similarity). Taurus_UMD|evm.model.AC_000179.1.364 O43818 U3IP2_HUMAN 93.263 0.995798 1.00211 RRP9 - U3 small nucleolar RNA-interacting protein 2 - Homo sapiens (Human) - RRP9 gene Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA). Taurus_UMD|evm.model.AC_000179.1.365 Q3SYS7 IQCF1_BOVIN 100.000 0.990476 1.00478 IQCF1 - IQ domain-containing protein F1 - Bos taurus (Bovine) - IQCF1 gene Involved in sperm capacitation and acrosome reaction. Taurus_UMD|evm.model.AC_000179.1.366 Q32KU4 IQCF5_BOVIN 100.000 0.986667 1.00671 IQCF5 - IQ domain-containing protein F5 - Bos taurus (Bovine) - IQCF5 gene calmodulin binding Taurus_UMD|evm.model.AC_000179.1.367 Q2M2U5 IQCF2_BOVIN 100.000 0.987805 1.00613 IQCF2 - IQ domain-containing protein F2 - Bos taurus (Bovine) - IQCF2 gene calmodulin binding Taurus_UMD|evm.model.AC_000179.1.368 P0C7M6 IQCF3_HUMAN 59.494 0.817708 1.24675 IQCF3 - IQ domain-containing protein F3 - Homo sapiens (Human) - IQCF3 gene calmodulin binding Taurus_UMD|evm.model.AC_000179.1.369 Q32KU4 IQCF5_BOVIN 67.123 0.727273 1.32886 IQCF5 - IQ domain-containing protein F5 - Bos taurus (Bovine) - IQCF5 gene calmodulin binding Taurus_UMD|evm.model.AC_000179.1.370 A8MYZ5 IQCF6_HUMAN 98.131 0.981481 1.00935 IQCF6 - IQ domain-containing protein F6 - Homo sapiens (Human) - IQCF6 gene calmodulin binding Taurus_UMD|evm.model.AC_000179.1.372 Q148C9 HEBP1_BOVIN 97.906 0.989583 1.00524 HEBP1 - Heme-binding protein 1 - Bos taurus (Bovine) - HEBP1 gene May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity). Taurus_UMD|evm.model.AC_000179.1.373 Q14416 GRM2_HUMAN 98.624 0.997709 1.00115 GRM2 - Metabotropic glutamate receptor 2 precursor - Homo sapiens (Human) - GRM2 gene G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Taurus_UMD|evm.model.AC_000179.1.374 Q9Y6I9 TX264_HUMAN 86.598 0.923567 1.00319 TEX264 - Testis-expressed protein 264 - Homo sapiens (Human) - TEX264 gene Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537). Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270). Taurus_UMD|evm.model.AC_000179.1.375 Q9Y4B4 ARIP4_HUMAN 96.768 0.737527 0.94274 RAD54L2 - Helicase ARIP4 - Homo sapiens (Human) - RAD54L2 gene DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). Taurus_UMD|evm.model.AC_000179.1.376 Q9Y4B6 DCAF1_HUMAN 98.275 0.998674 1.00066 DCAF1 - DDB1- and CUL4-associated factor 1 - Homo sapiens (Human) - DCAF1 gene Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:23362280). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription. H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). Taurus_UMD|evm.model.AC_000179.1.377 Q8NDT2 RB15B_HUMAN 96.425 0.997765 1.00562 RBM15B - Putative RNA-binding protein 15B - Homo sapiens (Human) - RBM15B gene RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). Taurus_UMD|evm.model.AC_000179.1.378 P80513 MANF_BOVIN 100.000 0.988889 1.00559 MANF - Mesencephalic astrocyte-derived neurotrophic factor precursor - Bos taurus (Bovine) - MANF gene Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions. Taurus_UMD|evm.model.AC_000179.1.379 Q8IZD9 DOCK3_HUMAN 94.951 0.991198 1.00739 DOCK3 - Dedicator of cytokinesis protein 3 - Homo sapiens (Human) - DOCK3 gene Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity). Taurus_UMD|evm.model.AC_000179.1.380 Q3SYZ2 MAPK3_BOVIN 100.000 0.994805 1.0026 MAPKAPK3 - MAP kinase-activated protein kinase 3 - Bos taurus (Bovine) - MAPKAPK3 gene Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression (By similarity). Taurus_UMD|evm.model.AC_000179.1.381 Q2HJ53 CISH_BOVIN 100.000 0.992157 1.00394 CISH - Cytokine-inducible SH2-containing protein - Bos taurus (Bovine) - CISH gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation (By similarity). May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Taurus_UMD|evm.model.AC_000179.1.382 Q9Y5R4 HEMK1_HUMAN 81.308 0.930029 1.01479 HEMK1 - MTRF1L release factor glutamine methyltransferase - Homo sapiens (Human) - HEMK1 gene N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L. Taurus_UMD|evm.model.AC_000179.1.383 Q9UK00 CC018_HUMAN 91.975 0.98773 1.00617 C3orf18 - Uncharacterized protein C3orf18 - Homo sapiens (Human) - C3orf18 gene Taurus_UMD|evm.model.AC_000179.1.385 Q9NY47 CA2D2_HUMAN 94.872 0.935484 0.997391 CACNA2D2 - Voltage-dependent calcium channel subunit alpha-2/delta-2 precursor - Homo sapiens (Human) - CACNA2D2 gene The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G) (PubMed:15111129, PubMed:23339110). Overexpression induces apoptosis. Taurus_UMD|evm.model.AC_000179.1.386 A4FUB8 TM115_BOVIN 100.000 0.994318 1.00285 TMEM115 - Transmembrane protein 115 - Bos taurus (Bovine) - TMEM115 gene May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. Taurus_UMD|evm.model.AC_000179.1.387 Q5E965 C56D2_BOVIN 100.000 0.991031 1.0045 CYB561D2 - Transmembrane reductase CYB561D2 - Bos taurus (Bovine) - CYB561D2 gene Transmembrane reductase that may use ascorbate as an electron donor in the cytoplasm and transfer electrons across endoplasmic reticulum membranes to reduce monodehydro-L-ascorbate radical and iron cations Fe(3+) in the lumen of that compartment. Taurus_UMD|evm.model.AC_000179.1.388 Q5E9U9 NPRL2_BOVIN 100.000 0.994751 1.00263 NPRL2 - GATOR complex protein NPRL2 - Bos taurus (Bovine) - NPRL2 gene As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. Taurus_UMD|evm.model.AC_000179.1.389 O75800 ZMY10_HUMAN 93.182 0.995455 1 ZMYND10 - Zinc finger MYND domain-containing protein 10 - Homo sapiens (Human) - ZMYND10 gene Plays a role in axonemal structure organization and motility (PubMed:23891469, PubMed:23891471). Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity). May act by indirectly regulating transcription of dynein proteins (By similarity). Taurus_UMD|evm.model.AC_000179.1.390 Q9NS23 RASF1_HUMAN 93.314 0.994135 0.991279 RASSF1 - Ras association domain-containing protein 1 - Homo sapiens (Human) - RASSF1 gene Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. Taurus_UMD|evm.model.AC_000179.1.391 O75896 TUSC2_HUMAN 94.545 0.981982 1.00909 TUSC2 - Tumor suppressor candidate 2 - Homo sapiens (Human) - TUSC2 gene May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells. Taurus_UMD|evm.model.AC_000179.1.392 Q8SQG8 HYAL2_BOVIN 100.000 0.995781 1.00211 HYAL2 - Hyaluronidase-2 precursor - Bos taurus (Bovine) - HYAL2 gene Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity). Taurus_UMD|evm.model.AC_000179.1.393 Q5E985 HYAL1_BOVIN 99.563 0.609626 0.831111 HYAL1 - Hyaluronidase-1 precursor - Bos taurus (Bovine) - HYAL1 gene May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). Taurus_UMD|evm.model.AC_000179.1.394 Q12894 IFRD2_HUMAN 87.104 0.995465 0.871542 IFRD2 - Interferon-related developmental regulator 2 - Homo sapiens (Human) - IFRD2 gene nucleus Taurus_UMD|evm.model.AC_000179.1.395 Q8N112 LSME2_HUMAN 77.778 0.781915 1.14634 LSMEM2 - Leucine-rich single-pass membrane protein 2 - Homo sapiens (Human) - LSMEM2 gene Taurus_UMD|evm.model.AC_000179.1.396 Q13214 SEM3B_HUMAN 90.000 0.997333 1.00134 SEMA3B - Semaphorin-3B precursor - Homo sapiens (Human) - SEMA3B gene Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. Taurus_UMD|evm.model.AC_000179.1.398 P04899 GNAI2_HUMAN 99.437 0.994382 1.00282 GNAI2 - Guanine nucleotide-binding protein G(i) subunit alpha-2 - Homo sapiens (Human) - GNAI2 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Taurus_UMD|evm.model.AC_000179.1.399 Q99624 S38A3_HUMAN 89.683 0.99604 1.00198 SLC38A3 - Sodium-coupled neutral amino acid transporter 3 - Homo sapiens (Human) - SLC38A3 gene Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission. Taurus_UMD|evm.model.AC_000179.1.400 P04695 GNAT1_BOVIN 100.000 0.938172 1.06286 GNAT1 - Guanine nucleotide-binding protein G(t) subunit alpha-1 - Bos taurus (Bovine) - GNAT1 gene Functions as signal transducer for the rod photoreceptor RHO (PubMed:21285355, PubMed:23303210, PubMed:28655769, PubMed:8259210). Required for normal RHO-mediated light perception by the retina (By similarity). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:21285355, PubMed:28655769, PubMed:8259210, PubMed:8208289, PubMed:7969474). Activated RHO promotes GDP release and GTP binding (PubMed:21285355, PubMed:28655769). Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (PubMed:21285355). Taurus_UMD|evm.model.AC_000179.1.401 Q13275 SEM3F_HUMAN 92.298 0.997478 1.01019 SEMA3F - Semaphorin-3F precursor - Homo sapiens (Human) - SEMA3F gene May play a role in cell motility and cell adhesion. Taurus_UMD|evm.model.AC_000179.1.402 Q1RMU5 RBM5_BOVIN 100.000 0.997549 1.00123 RBM5 - RNA-binding protein 5 - Bos taurus (Bovine) - RBM5 gene Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis (By similarity). Taurus_UMD|evm.model.AC_000179.1.403 P78332 RBM6_HUMAN 90.828 0.998216 0.998219 RBM6 - RNA-binding protein 6 - Homo sapiens (Human) - RBM6 gene Specifically binds poly(G) RNA homopolymers in vitro. Taurus_UMD|evm.model.AC_000179.1.404 Q17QV2 MON1A_BOVIN 100.000 0.996403 1.0018 MON1A - Vacuolar fusion protein MON1 homolog A - Bos taurus (Bovine) - MON1A gene Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Taurus_UMD|evm.model.AC_000179.1.405 Q04912 RON_HUMAN 80.722 0.982882 1.00143 MST1R - Macrophage-stimulating protein receptor precursor - Homo sapiens (Human) - MST1R gene Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. Taurus_UMD|evm.model.AC_000179.1.406 Q4QR76 ACL7B_RAT 42.507 0.287967 2.88969 Actl7b - Actin-like protein 7B - Rattus norvegicus (Rat) - Actl7b gene cytoplasm, dynactin complex, nucleus Taurus_UMD|evm.model.AC_000179.1.407 Q8NCB2 CAMKV_HUMAN 93.254 0.99604 1.00798 CAMKV - CaM kinase-like vesicle-associated protein - Homo sapiens (Human) - CAMKV gene Does not appear to have detectable kinase activity. Taurus_UMD|evm.model.AC_000179.1.408 Q9BWF2 TRAIP_HUMAN 81.529 0.993658 1.00853 TRAIP - E3 ubiquitin-protein ligase TRAIP - Homo sapiens (Human) - TRAIP gene E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:25335891, PubMed:26781088, PubMed:27462463, PubMed:26711499, PubMed:26595769, PubMed:31545170). Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity). Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (By similarity). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity). Only catalyzes ubiquitination of MCM7 when forks converge (By similarity). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is however controversial (PubMed:26595769). Acts as a regulator of the spindle assembly checkpoint (PubMed:25335891). Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (PubMed:22945920). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (PubMed:22945920). Taurus_UMD|evm.model.AC_000179.1.409 P41226 UBA7_HUMAN 76.285 0.997998 0.987154 UBA7 - Ubiquitin-like modifier-activating enzyme 7 - Homo sapiens (Human) - UBA7 gene Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein. Taurus_UMD|evm.model.AC_000179.1.410 Q96EL1 INKA1_HUMAN 82.168 0.992958 0.989547 INKA1 - PAK4-inhibitor INKA1 - Homo sapiens (Human) - INKA1 gene Inhibitor of the serine/threonine-protein kinase PAK4 (PubMed:26607847). Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity (PubMed:26607847). Taurus_UMD|evm.model.AC_000179.1.411 A6H8M9 CDHR4_HUMAN 75.450 0.983439 0.996193 CDHR4 - Cadherin-related family member 4 precursor - Homo sapiens (Human) - CDHR4 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). Taurus_UMD|evm.model.AC_000179.1.412 Q92551 IP6K1_HUMAN 96.145 0.995475 1.00227 IP6K1 - Inositol hexakisphosphate kinase 1 - Homo sapiens (Human) - IP6K1 gene Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Taurus_UMD|evm.model.AC_000179.1.413 Q2YDJ9 GMPPB_BOVIN 99.167 0.99446 1.00278 GMPPB - Mannose-1-phosphate guanyltransferase beta - Bos taurus (Bovine) - GMPPB gene Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. Taurus_UMD|evm.model.AC_000179.1.414 Q5XPI3 RN123_MOUSE 91.918 0.998488 1.00685 Rnf123 - E3 ubiquitin-protein ligase RNF123 - Mus musculus (Mouse) - Rnf123 gene Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS. Taurus_UMD|evm.model.AC_000179.1.415 Q24K22 HGFL_BOVIN 94.390 0.977961 1.01966 MST1 - Hepatocyte growth factor-like protein precursor - Bos taurus (Bovine) - MST1 gene extracellular space, receptor tyrosine kinase binding, serine-type endopeptidase activity, negative regulation of gluconeogenesis, positive regulation of mammary gland epithelial cell proliferation, regulation of cAMP-dependent protein kinase activity, regulation of macrophage chemotaxis Taurus_UMD|evm.model.AC_000179.1.416 P80227 ACPH_BOVIN 100.000 0.997264 1.00137 APEH - Acylamino-acid-releasing enzyme - Bos taurus (Bovine) - APEH gene This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. Taurus_UMD|evm.model.AC_000179.1.418 Q9UPA5 BSN_HUMAN 87.132 0.999289 0.716251 BSN - Protein bassoon - Homo sapiens (Human) - BSN gene Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Taurus_UMD|evm.model.AC_000179.1.419 Q9UPA5 BSN_HUMAN 85.759 0.92 0.171931 BSN - Protein bassoon - Homo sapiens (Human) - BSN gene Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Taurus_UMD|evm.model.AC_000179.1.420 O18738 DAG1_BOVIN 99.106 0.997768 1.00112 DAG1 - Dystroglycan precursor - Bos taurus (Bovine) - DAG1 gene The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Taurus_UMD|evm.model.AC_000179.1.422 Q5EAA5 TCTA_BOVIN 100.000 0.981308 1.00943 TCTA - T-cell leukemia translocation-altered gene protein homolog - Bos taurus (Bovine) - TCTA gene May be required for cellular fusion during osteoclastogenesis. Taurus_UMD|evm.model.AC_000179.1.423 P25285 GCST_BOVIN 100.000 0.980198 1.01763 AMT - Aminomethyltransferase, mitochondrial precursor - Bos taurus (Bovine) - AMT gene The glycine cleavage system catalyzes the degradation of glycine. Taurus_UMD|evm.model.AC_000179.1.424 Q861Y6 NICN1_CANLF 94.366 0.990385 0.976526 NICN1 - Nicolin-1 - Canis lupus familiaris (Dog) - NICN1 gene nucleoplasm Taurus_UMD|evm.model.AC_000179.1.425 Q5REY6 RHOA_PONAB 100.000 0.989691 1.00518 RHOA - Transforming protein RhoA precursor - Pongo abelii (Sumatran orangutan) - RHOA gene Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis. Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center. May be an activator of PLCE1. In neurons, involved in the inhibiton of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). Taurus_UMD|evm.model.AC_000179.1.426 P00435 GPX1_BOVIN 100.000 0.986207 0.707317 GPX1 - Glutathione peroxidase 1 - Bos taurus (Bovine) - GPX1 gene Protects the hemoglobin in erythrocytes from oxidative breakdown. In platelets, plays a crucial role of glutathione peroxidase in the arachidonic acid metabolism. Taurus_UMD|evm.model.AC_000179.1.427 A6QR55 UBP4_BOVIN 100.000 0.997925 1.00104 USP4 - Ubiquitin carboxyl-terminal hydrolase 4 - Bos taurus (Bovine) - USP4 gene Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER. Taurus_UMD|evm.model.AC_000179.1.428 Q6ZUJ4 CC062_HUMAN 80.827 0.89527 1.10861 C3orf62 - Uncharacterized protein C3orf62 - Homo sapiens (Human) - C3orf62 gene Taurus_UMD|evm.model.AC_000179.1.429 Q8IYA8 IHO1_HUMAN 67.384 0.996656 1.00673 IHO1 - Interactor of HORMAD1 protein 1 - Homo sapiens (Human) - IHO1 gene Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. Taurus_UMD|evm.model.AC_000179.1.430 H3BNL1 CC084_HUMAN 80.296 0.984848 0.970588 C3orf84 - Uncharacterized protein C3orf84 - Homo sapiens (Human) - C3orf84 gene Taurus_UMD|evm.model.AC_000179.1.431 Q5E9V5 KLD8B_BOVIN 99.718 0.994366 1.00282 KLHDC8B - Kelch domain-containing protein 8B - Bos taurus (Bovine) - KLHDC8B gene Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. Taurus_UMD|evm.model.AC_000179.1.432 Q2HJ91 CCD71_BOVIN 100.000 0.995585 1.00221 CCDC71 - Coiled-coil domain-containing protein 71 - Bos taurus (Bovine) - CCDC71 gene Taurus_UMD|evm.model.AC_000179.1.433 O94966 UBP19_HUMAN 93.768 0.21209 3.72762 USP19 - Ubiquitin carboxyl-terminal hydrolase 19 - Homo sapiens (Human) - USP19 gene Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains. Taurus_UMD|evm.model.AC_000179.1.434 Q3MHH4 SYQ_BOVIN 95.226 0.997301 0.956129 QARS1 - Glutamine--tRNA ligase - Bos taurus (Bovine) - QARS1 gene Glutamine--tRNA ligase. Plays a critical role in brain development. Taurus_UMD|evm.model.AC_000179.1.435 Q0P5J0 QRIC1_BOVIN 100.000 0.997436 1.00128 QRICH1 - Transcriptional regulator QRICH1 - Bos taurus (Bovine) - QRICH1 gene Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress. Controls the outcome of the unfolded protein response (UPR), an ER-stress response pathway that either promotes recovery of ER homeostasis and cell survival, or triggers the terminal UPR which elicits programmed cell death when ER stress is prolonged and unresolved. ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR. May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability. Upregulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver. Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth. Taurus_UMD|evm.model.AC_000179.1.436 Q3SWY3 IMDH2_BOVIN 100.000 0.996117 1.00195 IMPDH2 - Inosine-5'-monophosphate dehydrogenase 2 - Bos taurus (Bovine) - IMPDH2 gene Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Taurus_UMD|evm.model.AC_000179.1.437 Q2HJI2 NDUF3_BOVIN 100.000 0.989189 1.00543 NDUFAF3 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 - Bos taurus (Bovine) - NDUFAF3 gene Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Taurus_UMD|evm.model.AC_000179.1.439 Q5D0E6 DALD3_HUMAN 77.449 0.994465 0.998158 DALRD3 - DALR anticodon-binding domain-containing protein 3 - Homo sapiens (Human) - DALRD3 gene Involved in tRNA methylation. Facilitates the recognition and targeting of tRNA(Arg)(CCU) and tRNA(Arg)(UCU) substrates for N(3)-methylcytidine modification by METTL2A and METTL2B. Taurus_UMD|evm.model.AC_000179.1.440 A7Z052 WDR6_BOVIN 100.000 0.950085 1.0516 WDR6 - WD repeat-containing protein 6 - Bos taurus (Bovine) - WDR6 gene Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy. Taurus_UMD|evm.model.AC_000179.1.441 Q9NXG6 P4HTM_HUMAN 91.434 0.99596 0.986056 P4HTM - Transmembrane prolyl 4-hydroxylase - Homo sapiens (Human) - P4HTM gene Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Taurus_UMD|evm.model.AC_000179.1.442 O95376 ARI2_HUMAN 98.174 0.995935 0.997972 ARIH2 - E3 ubiquitin-protein ligase ARIH2 - Homo sapiens (Human) - ARIH2 gene E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). Taurus_UMD|evm.model.AC_000179.1.444 O43772 MCAT_HUMAN 93.688 0.993377 1.00332 SLC25A20 - Mitochondrial carnitine/acylcarnitine carrier protein - Homo sapiens (Human) - SLC25A20 gene Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Taurus_UMD|evm.model.AC_000179.1.445 P00515 KAP2_BOVIN 100.000 0.995025 1.00249 PRKAR2A - cAMP-dependent protein kinase type II-alpha regulatory subunit - Bos taurus (Bovine) - PRKAR2A gene Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase (By similarity). Taurus_UMD|evm.model.AC_000179.1.446 Q9UHH9 IP6K2_HUMAN 95.305 0.995305 1 IP6K2 - Inositol hexakisphosphate kinase 2 - Homo sapiens (Human) - IP6K2 gene Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Taurus_UMD|evm.model.AC_000179.1.447 Q9NZQ3 SPN90_HUMAN 90.509 0.997226 0.998615 NCKIPSD - NCK-interacting protein with SH3 domain - Homo sapiens (Human) - NCKIPSD gene Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. Taurus_UMD|evm.model.AC_000179.1.448 Q9NYQ7 CELR3_HUMAN 92.887 0.999397 1.00151 CELSR3 - Cadherin EGF LAG seven-pass G-type receptor 3 precursor - Homo sapiens (Human) - CELSR3 gene Receptor that may have an important role in cell/cell signaling during nervous system formation. Taurus_UMD|evm.model.AC_000179.1.449 Q9BXS9 S26A6_HUMAN 79.346 0.997382 1.00659 SLC26A6 - Solute carrier family 26 member 6 - Homo sapiens (Human) - SLC26A6 gene Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH. Taurus_UMD|evm.model.AC_000179.1.450 A2RUT3 TMM89_HUMAN 64.151 0.692982 1.43396 TMEM89 - Transmembrane protein 89 precursor - Homo sapiens (Human) - TMEM89 gene nucleus Taurus_UMD|evm.model.AC_000179.1.451 P31800 QCR1_BOVIN 99.792 0.995842 1.00208 UQCRC1 - Cytochrome b-c1 complex subunit 1, mitochondrial precursor - Bos taurus (Bovine) - UQCRC1 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (PubMed:9694818, PubMed:11073949). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Taurus_UMD|evm.model.AC_000179.1.452 Q02388 CO7A1_HUMAN 87.088 0.998976 0.995584 COL7A1 - Collagen alpha-1(VII) chain precursor - Homo sapiens (Human) - COL7A1 gene Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. Taurus_UMD|evm.model.AC_000179.1.453 Q4R8B6 F264_MACFA 98.507 0.995745 1.00213 PFKFB4 - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 - Macaca fascicularis (Crab-eating macaque) - PFKFB4 gene Synthesis and degradation of fructose 2,6-bisphosphate. Taurus_UMD|evm.model.AC_000179.1.454 Q3T0A9 SHSA5_BOVIN 92.130 0.99 0.925926 SHISA5 - Protein shisa-5 precursor - Bos taurus (Bovine) - SHISA5 gene Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. Taurus_UMD|evm.model.AC_000179.1.455 Q9BG99 TREX1_BOVIN 99.683 0.993671 1.00317 TREX1 - Three-prime repair exonuclease 1 - Bos taurus (Bovine) - TREX1 gene Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity). Taurus_UMD|evm.model.AC_000179.1.456 Q9N077 ATRIP_MACFA 81.942 0.83038 1.20611 ATRIP - ATR-interacting protein - Macaca fascicularis (Crab-eating macaque) - ATRIP gene Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein (By similarity). Taurus_UMD|evm.model.AC_000179.1.457 Q8K003 TMA7_MOUSE 100.000 0.969231 1.01562 Tma7 - Translation machinery-associated protein 7 - Mus musculus (Mouse) - Tma7 gene cytoplasmic translation Taurus_UMD|evm.model.AC_000179.1.458 Q5E9Q3 MITOK_BOVIN 100.000 0.170553 5.73267 CCDC51 - Mitochondrial potassium channel precursor - Bos taurus (Bovine) - CCDC51 gene Mitochondrial potassium channel located in the mitochondrial inner membrane. Together with ABCB8/MITOSUR, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel). May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume. Taurus_UMD|evm.model.AC_000179.1.459 O43157 PLXB1_HUMAN 97.630 0.990566 0.0992974 PLXNB1 - Plexin-B1 precursor - Homo sapiens (Human) - PLXNB1 gene Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496). Taurus_UMD|evm.model.AC_000179.1.461 O75414 NDK6_HUMAN 95.161 0.989305 1.00538 NME6 - Nucleoside diphosphate kinase 6 - Homo sapiens (Human) - NME6 gene Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis. Taurus_UMD|evm.model.AC_000179.1.462 P56425 CTHL7_BOVIN 100.000 0.987952 1.00606 CATHL7 - Cathelicidin-7 precursor - Bos taurus (Bovine) - CATHL7 gene Exerts a potent antimicrobial activity. Taurus_UMD|evm.model.AC_000179.1.463 P22226 CTHL1_BOVIN 100.000 0.987179 1.00645 CATHL1 - Cathelicidin-1 precursor - Bos taurus (Bovine) - CATHL1 gene Potent microbicidal activity; active against S.aureus and E.coli. Taurus_UMD|evm.model.AC_000179.1.464 P50415 CTHL3_SHEEP 81.356 0.325843 0.936842 CATHL3 - Cathelicidin-3 precursor - Ovis aries (Sheep) - CATHL3 gene Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms (By similarity). Taurus_UMD|evm.model.AC_000179.1.465 P19661 CTHL3_BOVIN 100.000 0.988701 0.931579 CATHL3 - Cathelicidin-3 precursor - Bos taurus (Bovine) - CATHL3 gene Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms. Taurus_UMD|evm.model.AC_000179.1.466 P19660 CTHL2_BOVIN 100.000 0.988701 1.00568 CATHL2 - Cathelicidin-2 precursor - Bos taurus (Bovine) - CATHL2 gene Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms. Taurus_UMD|evm.model.AC_000179.1.467 P19661 CTHL3_BOVIN 77.869 0.975806 0.652632 CATHL3 - Cathelicidin-3 precursor - Bos taurus (Bovine) - CATHL3 gene Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms. Taurus_UMD|evm.model.AC_000179.1.468 P54228 CTHL6_BOVIN 100.000 0.987421 1.00633 CATHL6 - Cathelicidin-6 precursor - Bos taurus (Bovine) - CATHL6 gene Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi. Taurus_UMD|evm.model.AC_000179.1.469 P54229 CTHL5_BOVIN 100.000 0.9875 1.00629 CATHL5 - Cathelicidin-5 precursor - Bos taurus (Bovine) - CATHL5 gene Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi. Taurus_UMD|evm.model.AC_000179.1.470 A7MBD1 MPIP1_BOVIN 100.000 0.996198 1.0019 CDC25A - M-phase inducer phosphatase 1 - Bos taurus (Bovine) - CDC25A gene Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro (By similarity). Taurus_UMD|evm.model.AC_000179.1.471 P36225 MAP4_BOVIN 94.080 0.935154 1.09328 MAP4 - Microtubule-associated protein 4 - Bos taurus (Bovine) - MAP4 gene Non-neuronal microtubule-associated protein. Promotes microtubule assembly. Taurus_UMD|evm.model.AC_000179.1.472 Q2NKY8 DHX30_BOVIN 98.886 0.970711 0.979508 DHX30 - ATP-dependent RNA helicase DHX30 - Bos taurus (Bovine) - DHX30 gene RNA dependent helicase. Plays an important role in the assembly of the mitochondrial large ribosomal subunit. Required for optimal function of the zinc-finger antiviral protein ZC3HAV1. Associates with mitochondrial DNA. Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD. Taurus_UMD|evm.model.AC_000179.1.473 Q92922 SMRC1_HUMAN 94.019 0.971489 0.857014 SMARCC1 - SWI/SNF complex subunit SMARCC1 - Homo sapiens (Human) - SMARCC1 gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Taurus_UMD|evm.model.AC_000179.1.475 O95196 CSPG5_HUMAN 83.088 0.962617 0.94523 CSPG5 - Chondroitin sulfate proteoglycan 5 precursor - Homo sapiens (Human) - CSPG5 gene May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. Taurus_UMD|evm.model.AC_000179.1.476 Q0PNE2 ELP6_HUMAN 85.338 0.992509 1.00376 ELP6 - Elongator complex protein 6 - Homo sapiens (Human) - ELP6 gene Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:22854966). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in cell migration (By similarity). Taurus_UMD|evm.model.AC_000179.1.477 A6QM06 SCAP_BOVIN 99.922 0.998436 1.00078 SCAP - Sterol regulatory element-binding protein cleavage-activating protein - Bos taurus (Bovine) - SCAP gene Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain. Taurus_UMD|evm.model.AC_000179.1.478 Q9H3S7 PTN23_HUMAN 91.676 0.566626 1 PTPN23 - Tyrosine-protein phosphatase non-receptor type 23 - Homo sapiens (Human) - PTPN23 gene Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). Taurus_UMD|evm.model.AC_000179.1.479 P26202 P15A_RABIT 54.762 0.716763 1.26277 15 kDa protein A precursor - Oryctolagus cuniculus (Rabbit) Taurus_UMD|evm.model.AC_000179.1.480 E9Q4F2 KLH18_MOUSE 97.213 0.996522 1.00174 Klhl18 - Kelch-like protein 18 - Mus musculus (Mouse) - Klhl18 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis (By similarity). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (By similarity). Regulates light- and dark-dependent alpha-transducin localization changes in rod photoreceptors through UNC119 ubiquitination and degradation (PubMed:31696965). Preferentially ubiquitinates the unphosphorylated form of UNC119 over the phosphorylated form (PubMed:31696965). In the presence of UNC119, under dark-adapted conditions alpha-transducin mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light (PubMed:31696965). Taurus_UMD|evm.model.AC_000179.1.481 Q9HAQ2 KIF9_HUMAN 90.886 0.921637 1.08228 KIF9 - Kinesin-like protein KIF9 - Homo sapiens (Human) - KIF9 gene kinesin complex, microtubule, podosome, vesicle, ATPase activity, identical protein binding, microtubule binding, microtubule motor activity, extracellular matrix disassembly, microtubule-based movement Taurus_UMD|evm.model.AC_000179.1.482 Q9BYW2 SETD2_HUMAN 89.528 0.985981 1.00156 SETD2 - Histone-lysine N-methyltransferase SETD2 - Homo sapiens (Human) - SETD2 gene Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). Taurus_UMD|evm.model.AC_000179.1.483 Q8K5A9 NRADD_RAT 74.459 0.991304 1.00877 Nradd - Death domain-containing membrane protein NRADD - Rattus norvegicus (Rat) - Nradd gene Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR (By similarity). Both isoform 1 and isoform 2 promote apoptosis. Taurus_UMD|evm.model.AC_000179.1.484 Q6ZNJ1 NBEL2_HUMAN 88.214 0.998874 0.96732 NBEAL2 - Neurobeachin-like protein 2 - Homo sapiens (Human) - NBEAL2 gene Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. Taurus_UMD|evm.model.AC_000179.1.485 Q8WUD4 CCD12_HUMAN 91.667 0.988166 1.01807 CCDC12 - Coiled-coil domain-containing protein 12 - Homo sapiens (Human) - CCDC12 gene post-mRNA release spliceosomal complex, U2-type spliceosomal complex Taurus_UMD|evm.model.AC_000179.1.486 Q1LZF7 PTH1R_BOVIN 99.830 0.99661 1.0017 PTH1R - Parathyroid hormone/parathyroid hormone-related peptide receptor precursor - Bos taurus (Bovine) - PTH1R gene Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000179.1.487 P85100 MYL3_BOVIN 100.000 0.99 1.00503 MYL3 - Myosin light chain 3 - Bos taurus (Bovine) - MYL3 gene Regulatory light chain of myosin. Does not bind calcium. Taurus_UMD|evm.model.AC_000179.1.488 Q7Z5A4 PRS42_HUMAN 54.949 0.852071 1.15358 PRSS42P - Putative serine protease 42 precursor - Homo sapiens (Human) - PRSS42P gene Plays a role in spermatogenesis. Involved in germ cell survival during meiosis. Taurus_UMD|evm.model.AC_000179.1.489 Q402U7 PRS44_MOUSE 59.058 0.689223 1.07258 Prss44 - Serine protease 44 precursor - Mus musculus (Mouse) - Prss44 gene cytoplasm, extracellular space, serine-type endopeptidase activity, germ cell development, proteolysis, spermatogenesis Taurus_UMD|evm.model.AC_000179.1.490 Q402U7 PRS44_MOUSE 46.243 0.887052 0.975806 Prss44 - Serine protease 44 precursor - Mus musculus (Mouse) - Prss44 gene cytoplasm, extracellular space, serine-type endopeptidase activity, germ cell development, proteolysis, spermatogenesis Taurus_UMD|evm.model.AC_000179.1.491 Q402U7 PRS44_MOUSE 51.685 0.418384 1.69624 Prss44 - Serine protease 44 precursor - Mus musculus (Mouse) - Prss44 gene cytoplasm, extracellular space, serine-type endopeptidase activity, germ cell development, proteolysis, spermatogenesis Taurus_UMD|evm.model.AC_000179.1.492 A2VE36 PRS45_BOVIN 99.684 0.993691 1.00316 PRSS45 - Serine protease 45 precursor - Bos taurus (Bovine) - PRSS45 gene extracellular space, serine-type endopeptidase activity, proteolysis Taurus_UMD|evm.model.AC_000179.1.493 E5RG02 PRS46_HUMAN 69.643 0.532051 1.7931 PRSS46P - Putative serine protease 46 - Homo sapiens (Human) - PRSS46P gene extracellular space, serine-type endopeptidase activity, proteolysis Taurus_UMD|evm.model.AC_000179.1.494 Q9UI38 TSP50_HUMAN 61.930 0.953368 1.0026 PRSS50 - Probable threonine protease PRSS50 precursor - Homo sapiens (Human) - PRSS50 gene May be involved in proteolysis through its threonine endopeptidase activity. Taurus_UMD|evm.model.AC_000179.1.495 Q8K467 TMIE_MOUSE 94.531 0.962121 0.862745 Tmie - Transmembrane inner ear expressed protein precursor - Mus musculus (Mouse) - Tmie gene Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain. Taurus_UMD|evm.model.AC_000179.1.496 A6QP75 AL2CL_BOVIN 99.895 0.962588 1.03778 ALS2CL - ALS2 C-terminal-like protein - Bos taurus (Bovine) - ALS2CL gene Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics (By similarity). Taurus_UMD|evm.model.AC_000179.1.497 A0A1B0GVK7 F240A_HUMAN 87.013 0.926829 1.06494 FAM240A - Protein FAM240A - Homo sapiens (Human) - FAM240A gene Taurus_UMD|evm.model.AC_000179.1.498 Q9BYS8 LRRC2_HUMAN 87.606 0.919481 1.03774 LRRC2 - Leucine-rich repeat-containing protein 2 - Homo sapiens (Human) - LRRC2 gene cytoplasm, intracellular membrane-bounded organelle, protein serine/threonine phosphatase activity, signal transduction Taurus_UMD|evm.model.AC_000179.1.499 Q9BQQ7 RTP3_HUMAN 72.840 0.528053 1.30603 RTP3 - Receptor-transporting protein 3 - Homo sapiens (Human) - RTP3 gene Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43. Taurus_UMD|evm.model.AC_000179.1.500 P24627 TRFL_BOVIN 100.000 0.883249 1.11299 LTF - Lactotransferrin precursor - Bos taurus (Bovine) - LTF gene Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Taurus_UMD|evm.model.AC_000179.1.501 Q0II78 CCRL2_BOVIN 100.000 0.994269 1.00287 CCRL2 - Chemokine C-C motif receptor-like 2 - Bos taurus (Bovine) - CCRL2 gene Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses (By similarity). Taurus_UMD|evm.model.AC_000179.1.502 Q2HJ17 CCR5_BOVIN 100.000 0.994334 1.00284 CCR5 - C-C chemokine receptor type 5 - Bos taurus (Bovine) - CCR5 gene Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. Taurus_UMD|evm.model.AC_000179.1.503 Q2HJ17 CCR5_BOVIN 80.000 0.916442 1.05398 CCR5 - C-C chemokine receptor type 5 - Bos taurus (Bovine) - CCR5 gene Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. Taurus_UMD|evm.model.AC_000179.1.505 Q64H34 CCR3_CANLF 79.609 0.991643 1 CCR3 - C-C chemokine receptor type 3 - Canis lupus familiaris (Dog) - CCR3 gene Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. Taurus_UMD|evm.model.AC_000179.1.506 P32246 CCR1_HUMAN 66.978 0.864641 1.01972 CCR1 - C-C chemokine receptor type 1 - Homo sapiens (Human) - CCR1 gene Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. Taurus_UMD|evm.model.AC_000179.1.507 P32246 CCR1_HUMAN 84.507 0.994382 1.00282 CCR1 - C-C chemokine receptor type 1 - Homo sapiens (Human) - CCR1 gene Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. Taurus_UMD|evm.model.AC_000179.1.508 Q99567 NUP88_HUMAN 89.189 0.982143 0.151147 NUP88 - Nuclear pore complex protein Nup88 - Homo sapiens (Human) - NUP88 gene Component of nuclear pore complex. Taurus_UMD|evm.model.AC_000179.1.509 P46094 XCR1_HUMAN 78.378 0.994012 1.003 XCR1 - Chemokine XC receptor 1 - Homo sapiens (Human) - XCR1 gene Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin. Taurus_UMD|evm.model.AC_000179.1.510 Q9BQS8 FYCO1_HUMAN 77.282 0.997892 0.962788 FYCO1 - FYVE and coiled-coil domain-containing protein 1 - Homo sapiens (Human) - FYCO1 gene May mediate microtubule plus end-directed vesicle transport. Taurus_UMD|evm.model.AC_000179.1.512 Q1WLP9 CCR9_SHEEP 95.556 0.607445 1.61035 CCR9 - C-C chemokine receptor type 9 - Ovis aries (Sheep) - CCR9 gene Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level (By similarity). Taurus_UMD|evm.model.AC_000179.1.513 Q3ZBL4 LZTL1_BOVIN 100.000 0.965909 0.882943 LZTFL1 - Leucine zipper transcription factor-like protein 1 - Bos taurus (Bovine) - LZTFL1 gene Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function (By similarity). Taurus_UMD|evm.model.AC_000179.1.514 Q9NP91 S6A20_HUMAN 90.372 0.996627 1.00169 SLC6A20 - Sodium- and chloride-dependent transporter XTRP3 - Homo sapiens (Human) - SLC6A20 gene Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Involved in the transport of glycine. Taurus_UMD|evm.model.AC_000179.1.515 A6QL88 SAC1_BOVIN 100.000 0.996599 1.0017 SACM1L - Phosphatidylinositol-3-phosphatase SAC1 - Bos taurus (Bovine) - SACM1L gene Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (By similarity). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (By similarity). Taurus_UMD|evm.model.AC_000179.1.516 Q06BR1 LIMD1_XENLA 79.032 0.105172 0.947712 limd1 - LIM domain-containing protein 1 - Xenopus laevis (African clawed frog) - limd1 gene Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development. Taurus_UMD|evm.model.AC_000179.1.517 Q5RDP4 SYLM_PONAB 86.711 0.99774 0.980066 LARS2 - Probable leucine--tRNA ligase, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - LARS2 gene Taurus_UMD|evm.model.AC_000179.1.518 A2VDX9 TM158_BOVIN 100.000 0.993151 1.00344 TMEM158 - Transmembrane protein 158 precursor - Bos taurus (Bovine) - TMEM158 gene Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide. Taurus_UMD|evm.model.AC_000179.1.519 Q28055 ARP19_BOVIN 95.536 0.982301 1.00893 ARPP19 - cAMP-regulated phosphoprotein 19 - Bos taurus (Bovine) - ARPP19 gene Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression (By similarity). Taurus_UMD|evm.model.AC_000179.1.520 Q7YRK6 CX6B1_CARSF 91.860 0.977011 1.01163 COX6B1 - Cytochrome c oxidase subunit 6B1 - Carlito syrichta (Philippine tarsier) - COX6B1 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Taurus_UMD|evm.model.AC_000179.1.521 Q9H5V8 CDCP1_HUMAN 79.901 0.946199 1.02273 CDCP1 - CUB domain-containing protein 1 precursor - Homo sapiens (Human) - CDCP1 gene May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. Taurus_UMD|evm.model.AC_000179.1.522 Q2KIS7 TETN_BOVIN 100.000 0.636678 1.43069 CLEC3B - Tetranectin precursor - Bos taurus (Bovine) - CLEC3B gene Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis (By similarity). Taurus_UMD|evm.model.AC_000179.1.523 Q15024 EXOS7_HUMAN 96.907 0.993151 1.00344 EXOSC7 - Exosome complex component RRP42 - Homo sapiens (Human) - EXOSC7 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Taurus_UMD|evm.model.AC_000179.1.524 Q9NYG2 ZDHC3_HUMAN 88.850 0.848665 1.12709 ZDHHC3 - Palmitoyltransferase ZDHHC3 - Homo sapiens (Human) - ZDHHC3 gene Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:19001095, PubMed:21926431, PubMed:22240897, PubMed:23034182, PubMed:22314500). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (PubMed:19001095). Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (PubMed:22314500). Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (PubMed:22240897). In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation. Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses. Palmitoylates NCDN thereby regulating its association with endosome membranes. Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor. Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth. Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes. Also constitutively palmitoylates DLG4. May also palmitoylate SNAP25. Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (By similarity). Could also palmitoylate the D(2) dopamine receptor DRD2 (PubMed:26535572). Taurus_UMD|evm.model.AC_000179.1.525 Q2KIX3 TMM42_BOVIN 100.000 0.9875 1.00629 TMEM42 - Transmembrane protein 42 - Bos taurus (Bovine) - TMEM42 gene Taurus_UMD|evm.model.AC_000179.1.526 Q9BDJ6 GHRL_BOVIN 100.000 0.256696 3.86207 GHRL - Appetite-regulating hormone precursor - Bos taurus (Bovine) - GHRL gene Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity). Taurus_UMD|evm.model.AC_000179.1.528 Q01814 AT2B2_HUMAN 93.546 0.998399 1.00483 ATP2B2 - Plasma membrane calcium-transporting ATPase 2 - Homo sapiens (Human) - ATP2B2 gene ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:17234811, PubMed:15829536). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:17234811, PubMed:15829536). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:17234811, PubMed:15829536). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:17234811, PubMed:15829536). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). Taurus_UMD|evm.model.AC_000179.1.530 P31647 S6A11_RAT 92.881 0.568665 0.824561 Slc6a11 - Sodium- and chloride-dependent GABA transporter 3 - Rattus norvegicus (Rat) - Slc6a11 gene Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Taurus_UMD|evm.model.AC_000179.1.531 P30531 SC6A1_HUMAN 97.663 0.996667 1.00167 SLC6A1 - Sodium- and chloride-dependent GABA transporter 1 - Homo sapiens (Human) - SLC6A1 gene Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Taurus_UMD|evm.model.AC_000179.1.534 P30546 HRH1_BOVIN 98.778 0.995935 1.00204 HRH1 - Histamine H1 receptor - Bos taurus (Bovine) - HRH1 gene In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Taurus_UMD|evm.model.AC_000179.1.535 O95352 ATG7_HUMAN 94.310 0.997159 1.00142 ATG7 - Ubiquitin-like modifier-activating enzyme ATG7 - Homo sapiens (Human) - ATG7 gene E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000179.1.536 Q14135 VGLL4_HUMAN 89.883 0.860544 1.01379 VGLL4 - Transcription cofactor vestigial-like protein 4 - Homo sapiens (Human) - VGLL4 gene May act as a specific coactivator for the mammalian TEFs. Taurus_UMD|evm.model.AC_000179.1.537 Q14135 VGLL4_HUMAN 100.000 0.215054 0.32069 VGLL4 - Transcription cofactor vestigial-like protein 4 - Homo sapiens (Human) - VGLL4 gene May act as a specific coactivator for the mammalian TEFs. Taurus_UMD|evm.model.AC_000179.1.538 Q32L81 TAM41_BOVIN 99.407 0.994083 1.00896 TAMM41 - Phosphatidate cytidylyltransferase, mitochondrial - Bos taurus (Bovine) - TAMM41 gene Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol. Taurus_UMD|evm.model.AC_000179.1.539 P20396 TRH_HUMAN 71.605 0.991736 1 TRH - Pro-thyrotropin-releasing hormone precursor - Homo sapiens (Human) - TRH gene As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes. Taurus_UMD|evm.model.AC_000179.1.541 O94876 TMCC1_HUMAN 96.018 0.996937 1 TMCC1 - Transmembrane and coiled-coil domains protein 1 - Homo sapiens (Human) - TMCC1 gene Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Taurus_UMD|evm.model.AC_000179.1.542 Q9Y4D7 PLXD1_HUMAN 92.902 0.998856 0.908052 PLXND1 - Plexin-D1 precursor - Homo sapiens (Human) - PLXND1 gene Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E. Taurus_UMD|evm.model.AC_000179.1.543 Q3HNG7 H18_BOVIN 99.298 0.993007 0.833819 H1-8 - Histone H1.8 - Bos taurus (Bovine) - H1-8 gene May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity). Taurus_UMD|evm.model.AC_000179.1.545 P02699 OPSD_BOVIN 100.000 0.994269 1.00287 RHO - Rhodopsin - Bos taurus (Bovine) - RHO gene Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins (PubMed:10926528, PubMed:12044163, PubMed:11972040, PubMed:16908857, PubMed:16586416, PubMed:17060607, PubMed:17449675, PubMed:18818650, PubMed:21389983, PubMed:22198838, PubMed:23579341, PubMed:25205354, PubMed:27458239). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:1396673, PubMed:15111114). Taurus_UMD|evm.model.AC_000179.1.546 Q9HBG6 IF122_HUMAN 90.008 0.99839 1.00081 IFT122 - Intraflagellar transport protein 122 homolog - Homo sapiens (Human) - IFT122 gene As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking (PubMed:27932497, PubMed:29220510). Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity). Taurus_UMD|evm.model.AC_000179.1.547 O95243 MBD4_HUMAN 73.260 0.937388 0.963793 MBD4 - Methyl-CpG-binding domain protein 4 - Homo sapiens (Human) - MBD4 gene Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. Taurus_UMD|evm.model.AC_000179.1.548 Q95LL8 EFC12_MACFA 64.471 0.996534 1.01406 EFCAB12 - EF-hand calcium-binding domain-containing protein 12 - Macaca fascicularis (Crab-eating macaque) - EFCAB12 gene Taurus_UMD|evm.model.AC_000179.1.549 Q3SZQ6 RL32_BOVIN 100.000 0.985294 1.00741 RPL32 - 60S ribosomal protein L32 - Bos taurus (Bovine) - RPL32 gene cytosolic large ribosomal subunit Taurus_UMD|evm.model.AC_000179.1.550 O75155 CAND2_HUMAN 90.939 0.99834 0.974919 CAND2 - Cullin-associated NEDD8-dissociated protein 2 - Homo sapiens (Human) - CAND2 gene Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Taurus_UMD|evm.model.AC_000179.1.551 Q4FJU9 TMM40_MOUSE 82.707 0.616822 0.951111 Tmem40 - Transmembrane protein 40 - Mus musculus (Mouse) - Tmem40 gene Taurus_UMD|evm.model.AC_000179.1.552 A7E3S4 RAF1_BOVIN 93.281 0.848276 0.447531 RAF1 - RAF proto-oncogene serine/threonine-protein kinase - Bos taurus (Bovine) - RAF1 gene Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation (By similarity). Taurus_UMD|evm.model.AC_000179.1.553 Q9ERV1 MKRN2_MOUSE 95.349 0.831169 0.370192 Mkrn2 - Probable E3 ubiquitin-protein ligase makorin-2 - Mus musculus (Mouse) - Mkrn2 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Taurus_UMD|evm.model.AC_000179.1.554 A7E3S4 RAF1_BOVIN 100.000 0.723837 0.530864 RAF1 - RAF proto-oncogene serine/threonine-protein kinase - Bos taurus (Bovine) - RAF1 gene Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation (By similarity). Taurus_UMD|evm.model.AC_000179.1.555 A7E3S4 RAF1_BOVIN 98.936 0.962329 0.450617 RAF1 - RAF proto-oncogene serine/threonine-protein kinase - Bos taurus (Bovine) - RAF1 gene Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation (By similarity). Taurus_UMD|evm.model.AC_000179.1.556 Q9H000 MKRN2_HUMAN 88.235 0.984709 0.786058 MKRN2 - Probable E3 ubiquitin-protein ligase makorin-2 - Homo sapiens (Human) - MKRN2 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Taurus_UMD|evm.model.AC_000179.1.557 H3BPM6 MKROS_HUMAN 75.714 0.981221 0.955157 MKRN2OS - MKRN2 opposite strand protein - Homo sapiens (Human) - MKRN2OS gene Taurus_UMD|evm.model.AC_000179.1.558 Q8NCE0 SEN2_HUMAN 71.459 0.995652 0.989247 TSEN2 - tRNA-splicing endonuclease subunit Sen2 - Homo sapiens (Human) - TSEN2 gene Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity. Taurus_UMD|evm.model.AC_000179.1.560 O18971 PPARG_BOVIN 100.000 0.995798 0.942574 PPARG - Peroxisome proliferator-activated receptor gamma - Bos taurus (Bovine) - PPARG gene Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels. Taurus_UMD|evm.model.AC_000179.1.561 Q92777 SYN2_HUMAN 96.104 0.993528 0.530928 SYN2 - Synapsin-2 - Homo sapiens (Human) - SYN2 gene Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity). Taurus_UMD|evm.model.AC_000179.1.562 O97563 TIMP4_BOVIN 99.554 0.991111 1.00446 TIMP4 - Metalloproteinase inhibitor 4 precursor - Bos taurus (Bovine) - TIMP4 gene Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Taurus_UMD|evm.model.AC_000179.1.563 Q92777 SYN2_HUMAN 99.242 0.658291 0.341924 SYN2 - Synapsin-2 - Homo sapiens (Human) - SYN2 gene Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity). Taurus_UMD|evm.model.AC_000179.1.564 Q32L81 TAM41_BOVIN 79.149 0.532995 1.17612 TAMM41 - Phosphatidate cytidylyltransferase, mitochondrial - Bos taurus (Bovine) - TAMM41 gene Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol. Taurus_UMD|evm.model.AC_000179.1.565 Q9H1K0 RBNS5_HUMAN 87.023 0.997449 1 RBSN - Rabenosyn-5 - Homo sapiens (Human) - RBSN gene Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). Taurus_UMD|evm.model.AC_000179.1.566 P82669 RT25_BOVIN 100.000 0.988506 1.00578 MRPS25 - 28S ribosomal protein S25, mitochondrial - Bos taurus (Bovine) - MRPS25 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000179.1.567 P49116 NR2C2_HUMAN 97.819 0.944444 1.05705 NR2C2 - Nuclear receptor subfamily 2 group C member 2 - Homo sapiens (Human) - NR2C2 gene Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. Taurus_UMD|evm.model.AC_000179.1.568 Q80UZ0 FGD5_MOUSE 73.301 0.798797 1.22724 Fgd5 - FYVE, RhoGEF and PH domain-containing protein 5 - Mus musculus (Mouse) - Fgd5 gene Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). Taurus_UMD|evm.model.AC_000179.1.569 Q8ND61 CC020_HUMAN 68.886 0.997802 1.00664 C3orf20 - Uncharacterized protein C3orf20 - Homo sapiens (Human) - C3orf20 gene cytoplasm Taurus_UMD|evm.model.AC_000179.1.570 Q6PII3 CC174_HUMAN 89.722 0.995726 1.00214 CCDC174 - Coiled-coil domain-containing protein 174 - Homo sapiens (Human) - CCDC174 gene Probably involved in neuronal development. Taurus_UMD|evm.model.AC_000179.1.571 Q9C0E4 GRIP2_HUMAN 90.125 0.942029 1.05849 GRIP2 - Glutamate receptor-interacting protein 2 - Homo sapiens (Human) - GRIP2 gene May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Taurus_UMD|evm.model.AC_000179.1.572 Q9MZ34 SC6A6_BOVIN 99.514 0.725559 1.36935 SLC6A6 - Sodium- and chloride-dependent taurine transporter - Bos taurus (Bovine) - SLC6A6 gene Sodium-dependent taurine and beta-alanine transporter. Taurus_UMD|evm.model.AC_000179.1.574 P62311 LSM3_MOUSE 100.000 0.980583 1.0098 Lsm3 - U6 snRNA-associated Sm-like protein LSm3 - Mus musculus (Mouse) - Lsm3 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Taurus_UMD|evm.model.AC_000179.1.575 Q01831 XPC_HUMAN 72.458 0.997847 0.988298 XPC - DNA repair protein complementing XP-C cells - Homo sapiens (Human) - XPC gene Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:19609301, PubMed:20649465, PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:9734359, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). Taurus_UMD|evm.model.AC_000179.1.576 Q9DBS1 TMM43_MOUSE 93.000 0.995012 1.0025 Tmem43 - Transmembrane protein 43 - Mus musculus (Mouse) - Tmem43 gene May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane. Taurus_UMD|evm.model.AC_000179.1.577 Q2KHZ4 MIA40_BOVIN 100.000 0.985507 1.0073 CHCHD4 - Mitochondrial intermembrane space import and assembly protein 40 - Bos taurus (Bovine) - CHCHD4 gene Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes. Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake. Taurus_UMD|evm.model.AC_000179.1.578 Q5J3F6 V1R90_RAT 53.767 0.954098 0.983871 Vom1r90 - Vomeronasal type-1 receptor 90 - Rattus norvegicus (Rat) - Vom1r90 gene Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior. Taurus_UMD|evm.model.AC_000179.1.579 Q1KYK5 WNT7A_PONPY 98.567 0.994286 1.00287 WNT7A - Protein Wnt-7a precursor - Pongo pygmaeus (Bornean orangutan) - WNT7A gene Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation. Promotes formation of synapses via its interaction with FZD5 (By similarity). Taurus_UMD|evm.model.AC_000179.1.581 P37889 FBLN2_MOUSE 80.294 0.971706 1.0131 Fbln2 - Fibulin-2 precursor - Mus musculus (Mouse) - Fbln2 gene Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN. Taurus_UMD|evm.model.AC_000179.1.582 Q9GKU5 HDA11_MACFA 91.884 0.902887 1.09798 HDAC11 - Histone deacetylase 11 - Macaca fascicularis (Crab-eating macaque) - HDAC11 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Taurus_UMD|evm.model.AC_000179.1.583 Q9QY81 PO210_MOUSE 92.116 0.727273 0.174973 Nup210 - Nuclear pore membrane glycoprotein 210 precursor - Mus musculus (Mouse) - Nup210 gene Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. Taurus_UMD|evm.model.AC_000179.1.584 Q8TEM1 PO210_HUMAN 83.002 0.998718 0.826709 NUP210 - Nuclear pore membrane glycoprotein 210 precursor - Homo sapiens (Human) - NUP210 gene Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. Taurus_UMD|evm.model.AC_000179.1.589 Q8R0S2 IQEC1_MOUSE 90.226 0.838035 1.1436 Iqsec1 - IQ motif and SEC7 domain-containing protein 1 - Mus musculus (Mouse) - Iqsec1 gene Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin (By similarity). Involved in neuronal development (PubMed:31607425). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). Taurus_UMD|evm.model.AC_000179.1.590 Q9H845 ACAD9_HUMAN 85.161 0.995169 1 ACAD9 - Complex I assembly factor ACAD9, mitochondrial precursor - Homo sapiens (Human) - ACAD9 gene As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation (PubMed:20816094, PubMed:24158852). This moonlighting protein has also a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs (PubMed:12359260, PubMed:16020546, PubMed:21237683, PubMed:24158852). However, in vivo, it does not seem to play a primary role in fatty acid oxidation (PubMed:20816094, PubMed:24158852). In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein (PubMed:24158852). Taurus_UMD|evm.model.AC_000179.1.591 Q6ZUG5 YC006_HUMAN 66.818 0.395095 1.92483 Uncharacterized protein FLJ43738 - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000179.1.592 P0CG25 EFCC1_BOVIN 100.000 0.945833 0.40201 EFCC1 - EF-hand and coiled-coil domain-containing protein 1 - Bos taurus (Bovine) - EFCC1 gene cytosol Taurus_UMD|evm.model.AC_000179.1.593 P0CG25 EFCC1_BOVIN 98.624 0.489842 0.742044 EFCC1 - EF-hand and coiled-coil domain-containing protein 1 - Bos taurus (Bovine) - EFCC1 gene cytosol Taurus_UMD|evm.model.AC_000179.1.594 P14770 GPIX_HUMAN 68.212 0.828729 1.0226 GP9 - Platelet glycoprotein IX precursor - Homo sapiens (Human) - GP9 gene The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. Taurus_UMD|evm.model.AC_000179.1.595 Q53B90 RAB43_RAT 86.585 0.80198 0.480952 Rab43 - Ras-related protein Rab-43 - Rattus norvegicus (Rat) - Rab43 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Taurus_UMD|evm.model.AC_000179.1.596 Q86YS6 RAB43_HUMAN 86.842 0.403226 0.877358 RAB43 - Ras-related protein Rab-43 - Homo sapiens (Human) - RAB43 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Taurus_UMD|evm.model.AC_000179.1.597 Q6AYB3 ISY1_RAT 95.406 0.989474 1.00352 Isy1 - Pre-mRNA-splicing factor ISY1 homolog - Rattus norvegicus (Rat) - Isy1 gene Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state (By similarity). Involved in pre-mRNA splicing as component of the spliceosome. Taurus_UMD|evm.model.AC_000179.1.598 P62634 CNBP_RAT 100.000 0.988764 1.00565 Cnbp - Cellular nucleic acid-binding protein - Rattus norvegicus (Rat) - Cnbp gene Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression. Taurus_UMD|evm.model.AC_000179.1.599 P53620 COPG1_BOVIN 99.886 0.997714 1.00114 COPG1 - Coatomer subunit gamma-1 - Bos taurus (Bovine) - COPG1 gene The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity). Taurus_UMD|evm.model.AC_000179.1.600 Q96FZ2 HMCES_HUMAN 80.508 0.994366 1.00282 HMCES - Abasic site processing protein HMCES - Homo sapiens (Human) - HMCES gene Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877, PubMed:31235915, PubMed:31235913). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (PubMed:30554877, PubMed:31235913). The HMCES DNA-protein cross-link is then degraded by the proteasome (PubMed:30554877). Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (PubMed:31235915, PubMed:31806351). Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity). Taurus_UMD|evm.model.AC_000179.1.601 Q92522 H1X_HUMAN 90.654 0.990698 1.00939 H1-10 - Histone H1.10 - Homo sapiens (Human) - H1-10 gene Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. Taurus_UMD|evm.model.AC_000179.1.602 Q3T0F5 RAB7A_BOVIN 99.517 0.990385 1.00483 RAB7A - Ras-related protein Rab-7a - Bos taurus (Bovine) - RAB7A gene Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By similarity). Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes (By similarity). Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria (By similarity). Plays a role in the fusion of phagosomes with lysosomes (By similarity). Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses (By similarity). Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium) (By similarity). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (By similarity). Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (By similarity). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation (By similarity). Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Required for vesicular trafficking and cell surface expression of ACE2 (By similarity). May play a role in PRPH neuronal intermediate filament assembly (By similarity). Taurus_UMD|evm.model.AC_000179.1.604 Q9CPR4 RL17_MOUSE 95.758 0.901099 0.98913 Rpl17 - 60S ribosomal protein L17 - Mus musculus (Mouse) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000179.1.605 Q9GMB0 RPN1_PIG 95.392 0.959016 1.00329 RPN1 - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor - Sus scrofa (Pig) - RPN1 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (Probable). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Taurus_UMD|evm.model.AC_000179.1.607 P23769 GATA2_HUMAN 95.010 0.995842 1.00208 GATA2 - Endothelial transcription factor GATA-2 - Homo sapiens (Human) - GATA2 gene Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Taurus_UMD|evm.model.AC_000179.1.608 Q8NHS0 DNJB8_HUMAN 86.638 0.991379 1 DNAJB8 - DnaJ homolog subfamily B member 8 - Homo sapiens (Human) - DNAJB8 gene Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins. Taurus_UMD|evm.model.AC_000179.1.609 Q9JHW4 SELB_MOUSE 85.980 0.99661 1.01201 Eefsec - Selenocysteine-specific elongation factor - Mus musculus (Mouse) - Eefsec gene Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP. Taurus_UMD|evm.model.AC_000179.1.610 P60123 RUVB1_RAT 99.342 0.995624 1.00219 Ruvbl1 - RuvB-like 1 - Rattus norvegicus (Rat) - Ruvbl1 gene Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (By similarity). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (By similarity). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (By similarity). Essential for cell proliferation (By similarity). May be able to bind plasminogen at cell surface and enhance plasminogen activation (By similarity). Taurus_UMD|evm.model.AC_000179.1.611 Q5EA68 S61A1_BOVIN 100.000 0.995807 1.0021 SEC61A1 - Protein transport protein Sec61 subunit alpha isoform 1 - Bos taurus (Bovine) - SEC61A1 gene Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (By similarity). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity). Taurus_UMD|evm.model.AC_000179.1.613 Q3ZCT8 KBTBC_HUMAN 81.320 0.993127 0.934189 KBTBD12 - Kelch repeat and BTB domain-containing protein 12 - Homo sapiens (Human) - KBTBD12 gene Taurus_UMD|evm.model.AC_000179.1.617 Q99685 MGLL_HUMAN 85.809 0.993421 1.0033 MGLL - Monoglyceride lipase - Homo sapiens (Human) - MGLL gene Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333). Taurus_UMD|evm.model.AC_000179.1.618 Q5XIU1 ABTB1_RAT 83.054 0.995754 0.985356 Abtb1 - Ankyrin repeat and BTB/POZ domain-containing protein 1 - Rattus norvegicus (Rat) - Abtb1 gene May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes (By similarity). Taurus_UMD|evm.model.AC_000179.1.619 Q9NZ53 PDXL2_HUMAN 69.016 0.996593 0.970248 PODXL2 - Podocalyxin-like protein 2 precursor - Homo sapiens (Human) - PODXL2 gene Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins. Taurus_UMD|evm.model.AC_000179.1.620 P49736 MCM2_HUMAN 95.859 0.437158 1.2146 MCM2 - DNA replication licensing factor MCM2 - Homo sapiens (Human) - MCM2 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis. Taurus_UMD|evm.model.AC_000179.1.621 Q4V8X0 TPRA1_DANRE 78.341 0.675 0.846561 tpra1 - Transmembrane protein adipocyte-associated 1 homolog - Danio rerio (Zebrafish) - tpra1 gene Taurus_UMD|evm.model.AC_000179.1.627 Q9UIW2 PLXA1_HUMAN 93.181 0.967658 1.01108 PLXNA1 - Plexin-A1 precursor - Homo sapiens (Human) - PLXNA1 gene Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). Taurus_UMD|evm.model.AC_000179.1.629 Q32L35 MIC25_BOVIN 100.000 0.991561 1.00424 CHCHD6 - MICOS complex subunit MIC25 - Bos taurus (Bovine) - CHCHD6 gene Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Taurus_UMD|evm.model.AC_000179.1.630 Q86VQ6 TRXR3_HUMAN 83.212 0.828788 1.02644 TXNRD3 - Thioredoxin reductase 3 - Homo sapiens (Human) - TXNRD3 gene Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity). Taurus_UMD|evm.model.AC_000179.1.631 Q32PB5 CC022_BOVIN 100.000 0.985185 1.00746 Uncharacterized protein C3orf22 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000179.1.632 Q8NET6 CHSTD_HUMAN 81.765 0.991202 1 CHST13 - Carbohydrate sulfotransferase 13 - Homo sapiens (Human) - CHST13 gene Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan. Taurus_UMD|evm.model.AC_000179.1.633 Q8VC12 HUTU_MOUSE 88.889 0.473277 2.10355 Uroc1 - Urocanate hydratase - Mus musculus (Mouse) - Uroc1 gene cytosol, urocanate hydratase activity, histidine catabolic process Taurus_UMD|evm.model.AC_000179.1.634 Q5RFM9 AL1L1_PONAB 90.677 0.651702 1.53104 ALDH1L1 - Cytosolic 10-formyltetrahydrofolate dehydrogenase - Pongo abelii (Sumatran orangutan) - ALDH1L1 gene Taurus_UMD|evm.model.AC_000179.1.635 Q9UIH9 KLF15_HUMAN 78.935 0.95933 1.00481 KLF15 - Krueppel-like factor 15 - Homo sapiens (Human) - KLF15 gene Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. Taurus_UMD|evm.model.AC_000179.1.636 Q494V2 CP100_HUMAN 68.137 0.975806 1.01473 CFAP100 - Cilia- and flagella-associated protein 100 - Homo sapiens (Human) - CFAP100 gene May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm. Taurus_UMD|evm.model.AC_000180.1.3 O75071 EFC14_HUMAN 80.992 0.641711 0.377778 EFCAB14 - EF-hand calcium-binding domain-containing protein 14 - Homo sapiens (Human) - EFCAB14 gene Taurus_UMD|evm.model.AC_000180.1.4 A1A4L5 ALKB8_BOVIN 94.340 0.9875 0.240964 ALKBH8 - Alkylated DNA repair protein alkB homolog 8 - Bos taurus (Bovine) - ALKBH8 gene Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis (By similarity). Taurus_UMD|evm.model.AC_000180.1.5 A1A4L5 ALKB8_BOVIN 91.057 0.897059 0.204819 ALKBH8 - Alkylated DNA repair protein alkB homolog 8 - Bos taurus (Bovine) - ALKBH8 gene Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis (By similarity). Taurus_UMD|evm.model.AC_000180.1.6 P33610 PRI2_MOUSE 86.000 0.985876 0.70099 Prim2 - DNA primase large subunit - Mus musculus (Mouse) - Prim2 gene Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:8026492, PubMed:8253737). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:8253737). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:8253737). Stabilizes and modulates the activity of the catalytic subunit (PubMed:8253737). Taurus_UMD|evm.model.AC_000180.1.7 Q9ULC3 RAB23_HUMAN 94.937 0.991597 1.00422 RAB23 - Ras-related protein Rab-23 precursor - Homo sapiens (Human) - RAB23 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. Taurus_UMD|evm.model.AC_000180.1.8 Q3ZBG5 BAG2_BOVIN 100.000 0.990566 1.00474 BAG family molecular chaperone regulator 2 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000180.1.9 Q9HCI6 K1586_HUMAN 84.211 0.0531814 1.33799 KIAA1586 - E3 SUMO-protein ligase KIAA1586 - Homo sapiens (Human) - KIAA1586 gene E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins (PubMed:26524493). Taurus_UMD|evm.model.AC_000180.1.10 Q9HCI6 K1586_HUMAN 68.063 0.989529 0.242694 KIAA1586 - E3 SUMO-protein ligase KIAA1586 - Homo sapiens (Human) - KIAA1586 gene E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins (PubMed:26524493). Taurus_UMD|evm.model.AC_000180.1.11 Q9HCI6 K1586_HUMAN 70.588 0.859873 0.199492 KIAA1586 - E3 SUMO-protein ligase KIAA1586 - Homo sapiens (Human) - KIAA1586 gene E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins (PubMed:26524493). Taurus_UMD|evm.model.AC_000180.1.13 Q5SZJ8 BEND6_HUMAN 90.681 0.992857 1.00358 BEND6 - BEN domain-containing protein 6 - Homo sapiens (Human) - BEND6 gene Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis (PubMed:23571214). Taurus_UMD|evm.model.AC_000180.1.14 Q03001 DYST_HUMAN 82.261 0.974746 1.02523 DST - Dystonin - Homo sapiens (Human) - DST gene Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). Taurus_UMD|evm.model.AC_000180.1.15 Q96P44 COLA1_HUMAN 72.470 0.997636 0.884013 COL21A1 - Collagen alpha-1(XXI) chain precursor - Homo sapiens (Human) - COL21A1 gene collagen-containing extracellular matrix, cytosol, endoplasmic reticulum lumen, extracellular region, extracellular space, collagen fibril organization Taurus_UMD|evm.model.AC_000180.1.16 P22003 BMP5_HUMAN 95.374 0.995604 1.0022 BMP5 - Bone morphogenetic protein 5 precursor - Homo sapiens (Human) - BMP5 gene Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:11580864, PubMed:29321139). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:11580864). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:29321139, PubMed:11580864). Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (PubMed:20402566). Taurus_UMD|evm.model.AC_000180.1.18 D4A5C3 HMGC2_RAT 88.889 0.583333 0.489796 Hmgcll1 - 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic - Rattus norvegicus (Rat) - Hmgcll1 gene Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. Taurus_UMD|evm.model.AC_000180.1.19 Q8TB92 HMGC2_HUMAN 86.722 0.990783 0.586486 HMGCLL1 - 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic - Homo sapiens (Human) - HMGCLL1 gene Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. Taurus_UMD|evm.model.AC_000180.1.20 Q6UXV0 GFRAL_HUMAN 76.901 0.638838 1.39848 GFRAL - GDNF family receptor alpha-like precursor - Homo sapiens (Human) - GFRAL gene Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. Taurus_UMD|evm.model.AC_000180.1.21 Q9TUP7 OX2R_CANLF 98.333 0.99446 0.813063 HCRTR2 - Orexin receptor type 2 - Canis lupus familiaris (Dog) - HCRTR2 gene Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. Taurus_UMD|evm.model.AC_000180.1.22 O62809 OX2R_PIG 100.000 0.83908 0.195946 HCRTR2 - Orexin receptor type 2 - Sus scrofa (Pig) - HCRTR2 gene Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. Taurus_UMD|evm.model.AC_000180.1.23 Q5T0W9 FA83B_HUMAN 83.858 0.99803 1.00396 FAM83B - Protein FAM83B - Homo sapiens (Human) - FAM83B gene Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. Taurus_UMD|evm.model.AC_000180.1.25 Q3SZI1 TINAG_BOVIN 100.000 0.995807 1.0021 TINAG - Tubulointerstitial nephritis antigen - Bos taurus (Bovine) - TINAG gene Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein (By similarity). Taurus_UMD|evm.model.AC_000180.1.27 Q5VWP3 MLIP_HUMAN 86.857 0.198857 1.91048 MLIP - Muscular LMNA-interacting protein - Homo sapiens (Human) - MLIP gene Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD. Taurus_UMD|evm.model.AC_000180.1.28 Q3ZBH0 TCPB_BOVIN 98.165 0.864 0.233645 CCT2 - T-complex protein 1 subunit beta - Bos taurus (Bovine) - CCT2 gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Taurus_UMD|evm.model.AC_000180.1.29 Q9BTT6 LRRC1_HUMAN 94.656 0.99619 1.00191 LRRC1 - Leucine-rich repeat-containing protein 1 - Homo sapiens (Human) - LRRC1 gene cytosol Taurus_UMD|evm.model.AC_000180.1.30 Q9H511 KLH31_HUMAN 91.987 0.981102 1.00158 KLHL31 - Kelch-like protein 31 - Homo sapiens (Human) - KLHL31 gene Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). Taurus_UMD|evm.model.AC_000180.1.32 P48506 GSH1_HUMAN 94.035 0.995305 1.00314 GCLC - Glutamate--cysteine ligase catalytic subunit - Homo sapiens (Human) - GCLC gene cytosol, glutamate-cysteine ligase complex, ADP binding, glutamate binding, glutamate-cysteine ligase activity, magnesium ion binding, blood vessel diameter maintenance, cell redox homeostasis, cysteine metabolic process, glutamate metabolic process Taurus_UMD|evm.model.AC_000180.1.33 P18470 HB2D_CANLF 71.296 0.796296 1.01504 DLA class II histocompatibility antigen, DR-1 beta chain precursor - Canis lupus familiaris (Dog) Taurus_UMD|evm.model.AC_000180.1.34 P15981 HA2D_PIG 66.534 0.984252 0.996078 SLA class II histocompatibility antigen, DQ haplotype D alpha chain precursor - Sus scrofa (Pig) Taurus_UMD|evm.model.AC_000180.1.35 P06341 HB2A_RAT 67.130 0.616715 1.48927 RT1-B - Rano class II histocompatibility antigen, A beta chain - Rattus norvegicus (Rat) - RT1-B gene Involved in the presentation of foreign antigens to the immune system. Taurus_UMD|evm.model.AC_000180.1.36 P13765 DOB_HUMAN 75.926 0.988971 0.996337 HLA-DOB - HLA class II histocompatibility antigen, DO beta chain precursor - Homo sapiens (Human) - HLA-DOB gene Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. Taurus_UMD|evm.model.AC_000180.1.37 Q03519 TAP2_HUMAN 76.676 0.95 1.04956 TAP2 - Antigen peptide transporter 2 - Homo sapiens (Human) - TAP2 gene ABC transporter associated with antigen processing. In complex with TAP1 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules (PubMed:25656091, PubMed:25377891). Uses the chemical energy of ATP to export peptides against the concentration gradient (PubMed:25377891). During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle (PubMed:25377891, PubMed:25656091, PubMed:11274390). Typically transports intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome. Binds peptides with free N- and C-termini, the first three and the C-terminal residues being critical. Preferentially selects peptides having a highly hydrophobic residue at position 3 and hydrophobic or charged residues at the C-terminal anchor. Proline at position 2 has the most destabilizing effect (PubMed:7500034, PubMed:9256420, PubMed:11274390). As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation (PubMed:26611325, PubMed:1538751, PubMed:25377891). Taurus_UMD|evm.model.AC_000180.1.38 Q3T112 PSB8_BOVIN 100.000 0.99278 1.00362 PSMB8 - Proteasome subunit beta type-8 precursor - Bos taurus (Bovine) - PSMB8 gene The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides (By similarity). May participate in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (By similarity). Required for adipocyte differentiation (By similarity). Taurus_UMD|evm.model.AC_000180.1.39 Q28433 TAP1_GORGO 76.267 0.997337 1.00401 TAP1 - Antigen peptide transporter 1 - Gorilla gorilla gorilla (Western lowland gorilla) - TAP1 gene ABC transporter associated with antigen processing. In complex with TAP2 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules. Uses the chemical energy of ATP to export peptides against the concentration gradient. During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle. As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation. Taurus_UMD|evm.model.AC_000180.1.40 Q3SZC2 PSB9_BOVIN 100.000 0.990909 1.00457 PSMB9 - Proteasome subunit beta type-9 precursor - Bos taurus (Bovine) - PSMB9 gene The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides (By similarity). Taurus_UMD|evm.model.AC_000180.1.41 Q5R893 H2B1_PONAB 96.825 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000180.1.43 P28068 DMB_HUMAN 75.304 0.935361 1 HLA-DMB - HLA class II histocompatibility antigen, DM beta chain precursor - Homo sapiens (Human) - HLA-DMB gene Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Taurus_UMD|evm.model.AC_000180.1.44 P28067 DMA_HUMAN 73.709 0.985981 0.819923 HLA-DMA - HLA class II histocompatibility antigen, DM alpha chain precursor - Homo sapiens (Human) - HLA-DMA gene Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Taurus_UMD|evm.model.AC_000180.1.45 P06340 DOA_HUMAN 73.636 0.99095 0.884 HLA-DOA - HLA class II histocompatibility antigen, DO alpha chain precursor - Homo sapiens (Human) - HLA-DOA gene Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. Taurus_UMD|evm.model.AC_000180.1.47 Q32S26 BRD2_BOVIN 100.000 0.997512 1.00125 BRD2 - Bromodomain-containing protein 2 - Bos taurus (Bovine) - BRD2 gene Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly (By similarity). May play a role in spermatogenesis or folliculogenesis (By similarity). Taurus_UMD|evm.model.AC_000180.1.49 Q32S24 COBA2_BOVIN 97.869 0.998824 0.979839 COL11A2 - Collagen alpha-2(XI) chain precursor - Bos taurus (Bovine) - COL11A2 gene May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. Taurus_UMD|evm.model.AC_000180.1.50 P28702 RXRB_HUMAN 97.765 0.996276 1.0075 RXRB - Retinoic acid receptor RXR-beta - Homo sapiens (Human) - RXRB gene Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE). Taurus_UMD|evm.model.AC_000180.1.51 Q5TJF6 S39A7_CANLF 93.603 0.995745 1.00213 SLC39A7 - Zinc transporter SLC39A7 - Canis lupus familiaris (Dog) - SLC39A7 gene Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+). Taurus_UMD|evm.model.AC_000180.1.52 Q9XT00 DHB8_PIG 76.897 0.993127 1.12355 HSD17B8 - (3R)-3-hydroxyacyl-CoA dehydrogenase - Sus scrofa (Pig) - HSD17B8 gene Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex, acts as scaffold protein, required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference, this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD+(H). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters. NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2). Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one). Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol. Taurus_UMD|evm.model.AC_000180.1.53 A2T6X5 RING1_PANTR 98.413 0.891253 1.12202 RING1 - E3 ubiquitin-protein ligase RING1 - Pan troglodytes (Chimpanzee) - RING1 gene Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity). Taurus_UMD|evm.model.AC_000180.1.54 Q2T9M4 DRC7_BOVIN 92.453 0.393939 0.151376 DRC7 - Dynein regulatory complex subunit 7 - Bos taurus (Bovine) - DRC7 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility. Taurus_UMD|evm.model.AC_000180.1.55 Q8N1B4 VPS52_HUMAN 91.248 0.997429 1.07607 VPS52 - Vacuolar protein sorting-associated protein 52 homolog - Homo sapiens (Human) - VPS52 gene Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). Taurus_UMD|evm.model.AC_000180.1.56 P62271 RS18_RAT 100.000 0.986928 1.00658 Rps18 - 40S ribosomal protein S18 - Rattus norvegicus (Rat) - Rps18 gene Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. Taurus_UMD|evm.model.AC_000180.1.57 Q5TJE8 B3GT4_CANLF 82.289 0.952507 0.989556 B3GALT4 - Beta-1,3-galactosyltransferase 4 - Canis lupus familiaris (Dog) - B3GALT4 gene Involved in GM1/GD1B/GA1 ganglioside biosynthesis. Taurus_UMD|evm.model.AC_000180.1.58 O15213 WDR46_HUMAN 88.052 0.9967 0.993443 WDR46 - WD repeat-containing protein 46 - Homo sapiens (Human) - WDR46 gene Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus. Taurus_UMD|evm.model.AC_000180.1.59 Q17Q89 PFD6_BOVIN 100.000 0.984615 1.00775 PFDN6 - Prefoldin subunit 6 - Bos taurus (Bovine) - PFDN6 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Taurus_UMD|evm.model.AC_000180.1.60 Q5TJE5 RGL2_CANLF 91.805 0.997436 1 RGL2 - Ral guanine nucleotide dissociation stimulator-like 2 - Canis lupus familiaris (Dog) - RGL2 gene Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). Taurus_UMD|evm.model.AC_000180.1.61 O15533 TPSN_HUMAN 82.135 0.957589 1 TAPBP - Tapasin precursor - Homo sapiens (Human) - TAPBP gene Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). Taurus_UMD|evm.model.AC_000180.1.62 Q5TJE2 ZBT22_CANLF 90.981 0.982677 0.992188 ZBTB22 - Zinc finger and BTB domain-containing protein 22 - Canis lupus familiaris (Dog) - ZBTB22 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000180.1.63 Q5TJE1 DAXX_CANLF 86.605 0.99733 1.01628 DAXX - Death domain-associated protein 6 - Canis lupus familiaris (Dog) - DAXX gene Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX (By similarity). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (By similarity). Taurus_UMD|evm.model.AC_000180.1.64 Q5STR5 SIM40_HUMAN 79.221 0.938272 1.02532 SMIM40 - Small integral membrane protein 40 - Homo sapiens (Human) - SMIM40 gene Taurus_UMD|evm.model.AC_000180.1.65 Q08DJ8 HSF1_BOVIN 32.051 0.860606 0.314286 HSF1 - Heat shock factor protein 1 - Bos taurus (Bovine) - HSF1 gene Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes. Activation is reversible, and during the attenuation and recovery phase period of the heat shock response, returns to its unactivated form. Binds to inverted 5'-NGAAN-3' pentamer DNA sequences. Binds to chromatin at heat shock gene promoters. Plays also several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells. Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner. Plays a role in nuclear export of stress-induced HSP70 mRNA. Plays a role in the regulation of mitotic progression. Plays also a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner. Involved in stress-induced cancer cell proliferation in a IER5-dependent manner. Taurus_UMD|evm.model.AC_000180.1.66 Q9BW19 KIFC1_HUMAN 86.181 0.997019 0.997028 KIFC1 - Kinesin-like protein KIFC1 - Homo sapiens (Human) - KIFC1 gene Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). Taurus_UMD|evm.model.AC_000180.1.67 O43189 PHF1_HUMAN 96.649 0.996479 1.00176 PHF1 - PHD finger protein 1 - Homo sapiens (Human) - PHF1 gene Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. Taurus_UMD|evm.model.AC_000180.1.68 P69678 CUTA_BOVIN 98.305 0.988764 1.01136 CUTA - Protein CutA precursor - Bos taurus (Bovine) - CUTA gene May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE). Taurus_UMD|evm.model.AC_000180.1.69 Q96PV0 SYGP1_HUMAN 99.034 0.998515 1.00298 SYNGAP1 - Ras/Rap GTPase-activating protein SynGAP - Homo sapiens (Human) - SYNGAP1 gene Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity). Taurus_UMD|evm.model.AC_000180.1.70 Q96C00 ZBTB9_HUMAN 85.021 0.995671 0.976744 ZBTB9 - Zinc finger and BTB domain-containing protein 9 - Homo sapiens (Human) - ZBTB9 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000180.1.71 Q16611 BAK_HUMAN 86.256 0.990566 1.00474 BAK1 - Bcl-2 homologous antagonist/killer - Homo sapiens (Human) - BAK1 gene Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. Taurus_UMD|evm.model.AC_000180.1.72 Q5YKI7 GGNB1_HUMAN 63.551 0.27381 3.08257 GGNBP1 - Putative gametogenetin-binding protein 1 - Homo sapiens (Human) - GGNBP1 gene May be involved in spermatogenesis. Taurus_UMD|evm.model.AC_000180.1.73 Q8WN95 ITPR3_BOVIN 99.662 0.99925 1.00038 ITPR3 - Inositol 1,4,5-trisphosphate receptor type 3 - Bos taurus (Bovine) - ITPR3 gene Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Taurus_UMD|evm.model.AC_000180.1.74 Q3SZ13 UQCC2_BOVIN 81.618 0.982143 0.823529 UQCC2 - Ubiquinol-cytochrome-c reductase complex assembly factor 2 precursor - Bos taurus (Bovine) - UQCC2 gene Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability. Taurus_UMD|evm.model.AC_000180.1.75 Q96PC2 IP6K3_HUMAN 78.537 0.994859 0.94878 IP6K3 - Inositol hexakisphosphate kinase 3 - Homo sapiens (Human) - IP6K3 gene Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Taurus_UMD|evm.model.AC_000180.1.76 Q8NC56 LEMD2_HUMAN 89.484 0.995968 0.986083 LEMD2 - LEM domain-containing protein 2 - Homo sapiens (Human) - LEMD2 gene Involved in nuclear structure organization (PubMed:16339967). Required for maintaining the integrity of the nuclear envelope (PubMed:17097643). Taurus_UMD|evm.model.AC_000180.1.77 O62820 MOTI_BOVIN 99.123 0.495614 1.98261 MLN - Promotilin precursor - Bos taurus (Bovine) - MLN gene Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle. Taurus_UMD|evm.model.AC_000180.1.78 Q14833 GRM4_HUMAN 91.859 0.768036 0.987939 GRM4 - Metabotropic glutamate receptor 4 precursor - Homo sapiens (Human) - GRM4 gene G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. Taurus_UMD|evm.model.AC_000180.1.80 P17096 HMGA1_HUMAN 88.785 0.979381 0.906542 HMGA1 - High mobility group protein HMG-I/HMG-Y - Homo sapiens (Human) - HMGA1 gene HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. Taurus_UMD|evm.model.AC_000180.1.81 Q86T20 SIM29_HUMAN 97.059 0.980583 1.0098 SMIM29 - Small integral membrane protein 29 - Homo sapiens (Human) - SMIM29 gene Taurus_UMD|evm.model.AC_000180.1.82 A2VE79 NUDT3_BOVIN 100.000 0.988439 1.00581 NUDT3 - Diphosphoinositol polyphosphate phosphohydrolase 1 - Bos taurus (Bovine) - NUDT3 gene Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate (By similarity). Taurus_UMD|evm.model.AC_000180.1.83 P46783 RS10_HUMAN 100.000 0.987952 1.00606 RPS10 - 40S ribosomal protein S10 - Homo sapiens (Human) - RPS10 gene Component of the 40S ribosomal subunit. Taurus_UMD|evm.model.AC_000180.1.84 A7MBI0 PACN1_BOVIN 100.000 0.963043 1.03604 PACSIN1 - Protein kinase C and casein kinase substrate in neurons protein 1 - Bos taurus (Bovine) - PACSIN1 gene Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Taurus_UMD|evm.model.AC_000180.1.85 O95238 SPDEF_HUMAN 92.239 0.826733 1.20597 SPDEF - SAM pointed domain-containing Ets transcription factor - Homo sapiens (Human) - SPDEF gene May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. Taurus_UMD|evm.model.AC_000180.1.86 Q3TT38 ILRUN_MOUSE 100.000 0.940092 0.745704 Ilrun - Protein ILRUN - Mus musculus (Mouse) - Ilrun gene Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF. Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP. Taurus_UMD|evm.model.AC_000180.1.87 F6TFD9 RU1C_MACMU 100.000 0.9875 1.00629 SNRPC - U1 small nuclear ribonucleoprotein C - Macaca mulatta (Rhesus macaque) - SNRPC gene Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Taurus_UMD|evm.model.AC_000180.1.88 Q6BDS2 URFB1_HUMAN 88.504 0.998614 1.00208 UHRF1BP1 - UHRF1-binding protein 1 - Homo sapiens (Human) - UHRF1BP1 gene May act as a negative regulator of cell growth. Taurus_UMD|evm.model.AC_000180.1.89 Q5RA91 TAF11_PONAB 92.417 0.990521 1 TAF11 - Transcription initiation factor TFIID subunit 11 - Pongo abelii (Sumatran orangutan) - TAF11 gene Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). Taurus_UMD|evm.model.AC_000180.1.90 Q92625 ANS1A_HUMAN 88.103 0.998276 1.02293 ANKS1A - Ankyrin repeat and SAM domain-containing protein 1A - Homo sapiens (Human) - ANKS1A gene Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). Taurus_UMD|evm.model.AC_000180.1.93 Q8WWU5 TCP11_HUMAN 79.167 0.760305 1.30219 TCP11 - T-complex protein 11 homolog - Homo sapiens (Human) - TCP11 gene Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway. Taurus_UMD|evm.model.AC_000180.1.94 Q8IX30 SCUB3_HUMAN 96.878 0.997988 1.00101 SCUBE3 - Signal peptide, CUB and EGF-like domain-containing protein 3 precursor - Homo sapiens (Human) - SCUBE3 gene Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression. Taurus_UMD|evm.model.AC_000180.1.95 P36508 ZNF76_HUMAN 93.684 0.916264 1.08947 ZNF76 - Zinc finger protein 76 - Homo sapiens (Human) - ZNF76 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000180.1.96 Q9H4E7 DEFI6_HUMAN 93.502 0.996835 1.00158 DEF6 - Differentially expressed in FDCP 6 homolog - Homo sapiens (Human) - DEF6 gene Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). Taurus_UMD|evm.model.AC_000180.1.97 Q03181 PPARD_HUMAN 95.000 0.5467 1.82086 PPARD - Peroxisome proliferator-activated receptor delta - Homo sapiens (Human) - PPARD gene Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Taurus_UMD|evm.model.AC_000180.1.98 Q9HB96 FANCE_HUMAN 78.343 0.977819 1.00933 FANCE - Fanconi anemia group E protein - Homo sapiens (Human) - FANCE gene As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. Taurus_UMD|evm.model.AC_000180.1.99 P62907 RL10A_RAT 100.000 0.990826 1.00461 Rpl10a - 60S ribosomal protein L10a - Rattus norvegicus (Rat) - Rpl10a gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000180.1.100 Q99594 TEAD3_HUMAN 92.763 0.35108 2.97931 TEAD3 - Transcriptional enhancer factor TEF-5 - Homo sapiens (Human) - TEAD3 gene Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. Taurus_UMD|evm.model.AC_000180.1.101 Q13451 FKBP5_HUMAN 95.186 0.995633 1.00219 FKBP5 - Peptidyl-prolyl cis-trans isomerase FKBP5 - Homo sapiens (Human) - FKBP5 gene Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277). Taurus_UMD|evm.model.AC_000180.1.103 Q5T9G4 ARM12_HUMAN 86.310 0.985251 0.997059 ARMC12 - Armadillo repeat-containing protein 12 - Homo sapiens (Human) - ARMC12 gene nucleus Taurus_UMD|evm.model.AC_000180.1.104 Q6UWE3 COLL2_HUMAN 64.130 0.892157 1.02 CLPSL2 - Colipase-like protein 2 precursor - Homo sapiens (Human) - CLPSL2 gene response to food Taurus_UMD|evm.model.AC_000180.1.105 A0JNQ7 COL_BOVIN 100.000 0.982301 1.00893 CLPS - Colipase precursor - Bos taurus (Bovine) - CLPS gene Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Taurus_UMD|evm.model.AC_000180.1.106 Q5PPI7 LHPL5_RAT 99.087 0.990909 1.00457 Lhfpl5 - LHFPL tetraspan subfamily member 5 protein - Rattus norvegicus (Rat) - Lhfpl5 gene In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity). Taurus_UMD|evm.model.AC_000180.1.107 Q96SB4 SRPK1_HUMAN 89.942 0.997089 1.04885 SRPK1 - SRSF protein kinase 1 - Homo sapiens (Human) - SRPK1 gene Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. Taurus_UMD|evm.model.AC_000180.1.108 A6QNW6 S26A8_BOVIN 99.896 0.923003 1.08229 SLC26A8 - Testis anion transporter 1 - Bos taurus (Bovine) - SLC26A8 gene Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility (By similarity). Taurus_UMD|evm.model.AC_000180.1.109 Q16539 MK14_HUMAN 100.000 0.99446 1.00278 MAPK14 - Mitogen-activated protein kinase 14 - Homo sapiens (Human) - MAPK14 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113'. Taurus_UMD|evm.model.AC_000180.1.110 Q3T0N5 MK13_BOVIN 99.727 0.99455 1.00273 MAPK13 - Mitogen-activated protein kinase 13 - Bos taurus (Bovine) - MAPK13 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells (By similarity). Taurus_UMD|evm.model.AC_000180.1.111 Q9ULD4 BRPF3_HUMAN 94.283 0.998344 1.00249 BRPF3 - Bromodomain and PHD finger-containing protein 3 - Homo sapiens (Human) - BRPF3 gene Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Taurus_UMD|evm.model.AC_000180.1.112 Q8N8W4 PLPL1_HUMAN 70.790 0.992982 1.07143 PNPLA1 - Omega-hydroxyceramide transacylase - Homo sapiens (Human) - PNPLA1 gene Omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation (PubMed:27751867, PubMed:28248318). Catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramide (PubMed:27751867, PubMed:28248318). Omega-O-acylceramides, are required for the biogenesis of lipid lamellae in the stratum corneum and the formation of the cornified lipid envelope which are essential for the epidermis barrier function (PubMed:22246504, PubMed:27751867, PubMed:28248318). These lipids also play a role in keratinocyte differentiation (By similarity). May also act on omega-hydroxylated ultra-long chain fatty acids (omega-OH ULCFA) and acylglucosylceramides (GlcEOS) (By similarity). Taurus_UMD|evm.model.AC_000180.1.113 P0C671 BNIP5_HUMAN 55.489 0.996732 0.93865 BNIP5 - Protein BNIP5 - Homo sapiens (Human) - BNIP5 gene Taurus_UMD|evm.model.AC_000180.1.114 P09651 ROA1_HUMAN 97.619 0.753623 0.741935 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Homo sapiens (Human) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). Taurus_UMD|evm.model.AC_000180.1.115 Q8NFP0 PXT1_HUMAN 72.180 0.970588 1.01493 PXT1 - Peroxisomal testis-specific protein 1 - Homo sapiens (Human) - PXT1 gene nucleus, peroxisome, positive regulation of apoptotic process Taurus_UMD|evm.model.AC_000180.1.116 Q7Z5Y7 KCD20_HUMAN 93.556 0.995238 1.00239 KCTD20 - BTB/POZ domain-containing protein KCTD20 - Homo sapiens (Human) - KCTD20 gene Promotes the phosphorylation of AKT family members. Taurus_UMD|evm.model.AC_000180.1.117 A2VDV2 STK38_BOVIN 95.699 0.995565 0.969892 STK38 - Serine/threonine-protein kinase 38 - Bos taurus (Bovine) - STK38 gene Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity). Taurus_UMD|evm.model.AC_000180.1.118 P62752 RL23A_RAT 100.000 0.971831 0.455128 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000180.1.119 P61354 RL27_RAT 71.171 0.982143 0.823529 Rpl27 - 60S ribosomal protein L27 - Rattus norvegicus (Rat) - Rpl27 gene Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity). Taurus_UMD|evm.model.AC_000180.1.120 P84104 SRSF3_MOUSE 100.000 0.987879 1.0061 Srsf3 - Serine/arginine-rich splicing factor 3 - Mus musculus (Mouse) - Srsf3 gene Splicing factor that specifically promotes exon-inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. Also functions as export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. RNA-binding is semi-sequence specific. Taurus_UMD|evm.model.AC_000180.1.121 P79103 RS4_BOVIN 99.240 0.992424 1.0038 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000180.1.122 O19002 CDN1A_FELCA 85.366 0.737327 1.32317 CDKN1A - Cyclin-dependent kinase inhibitor 1 - Felis catus (Cat) - CDKN1A gene May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity). Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (By similarity). Taurus_UMD|evm.model.AC_000180.1.123 Q96FH0 BORC8_HUMAN 92.857 0.808824 0.571429 BORCS8 - BLOC-1-related complex subunit 8 - Homo sapiens (Human) - BORCS8 gene As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Taurus_UMD|evm.model.AC_000180.1.124 Q7Z6P3 RAB44_HUMAN 80.175 0.375412 0.892262 RAB44 - Ras-related protein Rab-44 - Homo sapiens (Human) - RAB44 gene azurophil granule membrane, plasma membrane, specific granule membrane, neutrophil degranulation Taurus_UMD|evm.model.AC_000180.1.125 Q8WPA2 AR_BOMMO 28.904 0.848397 0.950139 AR - Allatostatin-A receptor - Bombyx mori (Silk moth) - AR gene Acts as a receptor for A-type allatostatin neuropeptide hormones. Taurus_UMD|evm.model.AC_000180.1.126 Q9HCH3 CPNE5_HUMAN 91.148 0.99661 0.994941 CPNE5 - Copine-5 - Homo sapiens (Human) - CPNE5 gene Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Taurus_UMD|evm.model.AC_000180.1.127 Q9Y3C6 PPIL1_HUMAN 100.000 0.988024 1.00602 PPIL1 - Peptidyl-prolyl cis-trans isomerase-like 1 - Homo sapiens (Human) - PPIL1 gene Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688). Taurus_UMD|evm.model.AC_000180.1.128 Q5R9Q8 CF089_PONAB 84.770 0.994269 1.00576 Bombesin receptor-activated protein C6orf89 homolog - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000180.1.129 Q58D34 PI16_BOVIN 100.000 0.995699 1.00216 PI16 - Peptidase inhibitor 16 precursor - Bos taurus (Bovine) - PI16 gene May inhibit cardiomyocyte growth. Taurus_UMD|evm.model.AC_000180.1.130 Q9NZJ7 MTCH1_HUMAN 98.715 0.994872 1.00257 MTCH1 - Mitochondrial carrier homolog 1 - Homo sapiens (Human) - MTCH1 gene Potential mitochondrial transporter. May play a role in apoptosis. Taurus_UMD|evm.model.AC_000180.1.131 Q7Z6J4 FGD2_HUMAN 88.110 0.996956 1.00305 FGD2 - FYVE, RhoGEF and PH domain-containing protein 2 - Homo sapiens (Human) - FGD2 gene Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Taurus_UMD|evm.model.AC_000180.1.132 Q9N0P9 PIM1_BOVIN 100.000 0.66383 1.5016 PIM1 - Serine/threonine-protein kinase pim-1 - Bos taurus (Bovine) - PIM1 gene Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B, induces 14-3-3 protein binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis. Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells. Promotes brown adipocyte differentiation (By similarity). Taurus_UMD|evm.model.AC_000180.1.133 Q8N7C4 TM217_HUMAN 25.444 0.908108 0.80786 TMEM217 - Transmembrane protein 217 - Homo sapiens (Human) - TMEM217 gene Taurus_UMD|evm.model.AC_000180.1.134 Q8N7C4 TM217_HUMAN 64.398 0.984456 0.842795 TMEM217 - Transmembrane protein 217 - Homo sapiens (Human) - TMEM217 gene Taurus_UMD|evm.model.AC_000180.1.135 Q95LL3 TB22B_MACFA 98.812 0.996047 1.00198 TBC1D22B - TBC1 domain family member 22B - Macaca fascicularis (Crab-eating macaque) - TBC1D22B gene May act as a GTPase-activating protein for Rab family protein(s). Taurus_UMD|evm.model.AC_000180.1.136 Q2HJ46 RNF8_BOVIN 100.000 0.995902 1.00205 RNF8 - E3 ubiquitin-protein ligase RNF8 - Bos taurus (Bovine) - RNF8 gene E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites (By similarity). Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity (By similarity). In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2 (By similarity). Taurus_UMD|evm.model.AC_000180.1.137 A2VE39 CMTR1_BOVIN 100.000 0.684729 1.45868 CMTR1 - Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 - Bos taurus (Bovine) - CMTR1 gene S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. Taurus_UMD|evm.model.AC_000180.1.138 A1A4P9 CC167_BOVIN 100.000 0.979592 1.01031 CCDC167 - Coiled-coil domain-containing protein 167 - Bos taurus (Bovine) - CCDC167 gene Taurus_UMD|evm.model.AC_000180.1.139 Q8NFP4 MDGA1_HUMAN 97.192 0.997843 0.970681 MDGA1 - MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor - Homo sapiens (Human) - MDGA1 gene Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2. Taurus_UMD|evm.model.AC_000180.1.141 Q9H8U3 ZFAN3_HUMAN 97.797 0.991228 1.00441 ZFAND3 - AN1-type zinc finger protein 3 - Homo sapiens (Human) - ZFAND3 gene Taurus_UMD|evm.model.AC_000180.1.144 A4IFG2 BTBD9_BOVIN 99.836 0.728793 1.36989 BTBD9 - BTB/POZ domain-containing protein 9 - Bos taurus (Bovine) - BTBD9 gene adult locomotory behavior, circadian behavior, modulation of chemical synaptic transmission Taurus_UMD|evm.model.AC_000180.1.145 Q96JB1 DYH8_HUMAN 93.813 0.893165 1.0069 DNAH8 - Dynein axonemal heavy chain 8 - Homo sapiens (Human) - DNAH8 gene Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. Taurus_UMD|evm.model.AC_000180.1.146 Q32L85 SMDC1_BOVIN 100.000 0.989744 1.00515 SAYSD1 - SAYSvFN domain-containing protein 1 - Bos taurus (Bovine) - SAYSD1 gene Taurus_UMD|evm.model.AC_000180.1.147 O95279 KCNK5_HUMAN 88.778 0.995984 0.997996 KCNK5 - Potassium channel subfamily K member 5 - Homo sapiens (Human) - KCNK5 gene pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations. Taurus_UMD|evm.model.AC_000180.1.148 Q96T54 KCNKH_HUMAN 74.545 0.947368 1.03012 KCNK17 - Potassium channel subfamily K member 17 - Homo sapiens (Human) - KCNK17 gene Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Taurus_UMD|evm.model.AC_000180.1.149 Q96T55 KCNKG_HUMAN 82.838 0.989831 0.954693 KCNK16 - Potassium channel subfamily K member 16 - Homo sapiens (Human) - KCNK16 gene Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Taurus_UMD|evm.model.AC_000180.1.150 Q6ZMV9 KIF6_HUMAN 75.336 0.847107 0.297297 KIF6 - Kinesin-like protein KIF6 - Homo sapiens (Human) - KIF6 gene kinesin complex, microtubule, ATPase activity, microtubule binding, microtubule motor activity, microtubule-based movement Taurus_UMD|evm.model.AC_000180.1.151 Q6ZMV9 KIF6_HUMAN 66.667 0.885393 0.546683 KIF6 - Kinesin-like protein KIF6 - Homo sapiens (Human) - KIF6 gene kinesin complex, microtubule, ATPase activity, microtubule binding, microtubule motor activity, microtubule-based movement Taurus_UMD|evm.model.AC_000180.1.152 Q86T65 DAAM2_HUMAN 96.723 0.998127 1 DAAM2 - Disheveled-associated activator of morphogenesis 2 - Homo sapiens (Human) - DAAM2 gene Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. Taurus_UMD|evm.model.AC_000180.1.153 Q1JQD7 MOCS1_BOVIN 100.000 0.996845 1.00158 MOCS1 - Molybdenum cofactor biosynthesis protein 1 - Bos taurus (Bovine) - MOCS1 gene Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP. Taurus_UMD|evm.model.AC_000180.1.155 Q9BE71 LRFN2_MACFA 90.373 0.993769 0.406844 LRFN2 - Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor - Macaca fascicularis (Crab-eating macaque) - LRFN2 gene Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity). Taurus_UMD|evm.model.AC_000180.1.156 Q9ULH4 LRFN2_HUMAN 98.073 0.932 0.633714 LRFN2 - Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor - Homo sapiens (Human) - LRFN2 gene Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity). Taurus_UMD|evm.model.AC_000180.1.158 Q8IV45 UN5CL_HUMAN 87.452 0.996146 1.00193 UNC5CL - UNC5C-like protein - Homo sapiens (Human) - UNC5CL gene Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets. Taurus_UMD|evm.model.AC_000180.1.159 Q5TGU0 TSPO2_HUMAN 52.571 0.971429 1.02941 TSPO2 - Translocator protein 2 - Homo sapiens (Human) - TSPO2 gene Cholesterol-binding protein involved in the redistribution of cholesterol from lipid droplets to the endoplasmic reticulum (PubMed:19729679). Required to meet cholesterol demands during erythropoietic differentiation (PubMed:19729679). May play a role in transport processes at the plasma membrane of erythrocytes, including regulating VDAC-mediated ATP export, and import of the heme precursors protoporphyrin IX and 5-aminolevulinic acid (PubMed:27641616, PubMed:30061676, PubMed:31989647). Taurus_UMD|evm.model.AC_000180.1.160 Q3SYR3 ABEC2_BOVIN 100.000 0.991111 1.00446 APOBEC2 - Probable C->U-editing enzyme APOBEC-2 - Bos taurus (Bovine) - APOBEC2 gene Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Taurus_UMD|evm.model.AC_000180.1.161 Q1LZ74 OARD1_BOVIN 100.000 0.986928 1.00658 OARD1 - ADP-ribose glycohydrolase OARD1 - Bos taurus (Bovine) - OARD1 gene ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins. Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively. Taurus_UMD|evm.model.AC_000180.1.162 P23511 NFYA_HUMAN 91.066 0.99373 0.919308 NFYA - Nuclear transcription factor Y subunit alpha - Homo sapiens (Human) - NFYA gene Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1. Taurus_UMD|evm.model.AC_000180.1.163 Q9Z286 ADCYA_RAT 37.255 0.949153 0.990672 Adcy10 - Adenylate cyclase type 10 - Rattus norvegicus (Rat) - Adcy10 gene Catalyzes the formation of the signaling molecule cAMP (PubMed:9874775). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity). Taurus_UMD|evm.model.AC_000180.1.164 Q9NZC2 TREM2_HUMAN 79.736 0.417745 2.35217 TREM2 - Triggering receptor expressed on myeloid cells 2 precursor - Homo sapiens (Human) - TREM2 gene Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia (PubMed:27477018, PubMed:29518356). Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1 (By similarity). Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia (PubMed:27477018). Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin (PubMed:29794134). Regulates microglial proliferation by acting as an upstream regulator of the Wnt/beta-catenin signaling cascade (By similarity). Required for microglial phagocytosis of apoptotic neurons (PubMed:24990881). Also required for microglial activation and phagocytosis of myelin debris after neuronal injury and of neuronal synapses during synapse elimination in the developing brain (By similarity). Regulates microglial chemotaxis and process outgrowth, and also the microglial response to oxidative stress and lipopolysaccharide (By similarity). It suppresses PI3K and NF-kappa-B signaling in response to lipopolysaccharide; thus promoting phagocytosis, suppressing pro-inflammatory cytokine and nitric oxide production, inhibiting apoptosis and increasing expression of IL10 and TGFB (By similarity). During oxidative stress, it promotes anti-apoptotic NF-kappa-B signaling and ERK signaling (By similarity). Plays a role in microglial MTOR activation and metabolism (By similarity). Regulates age-related changes in microglial numbers (PubMed:29752066). Triggers activation of the immune responses in macrophages and dendritic cells (PubMed:10799849). Mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640). Involved in the positive regulation of osteoclast differentiation (PubMed:12925681). Taurus_UMD|evm.model.AC_000180.1.165 Q5T2D2 TRML2_HUMAN 61.162 0.73913 1.36137 TREML2 - Trem-like transcript 2 protein precursor - Homo sapiens (Human) - TREML2 gene Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. Taurus_UMD|evm.model.AC_000180.1.166 Q6QUN5 TREM1_BOVIN 99.138 0.991416 1.00431 TREM1 - Triggering receptor expressed on myeloid cells 1 precursor - Bos taurus (Bovine) - TREM1 gene Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of proinflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis. Taurus_UMD|evm.model.AC_000180.1.169 P20280 RL21_RAT 75.000 0.519231 0.325 Rpl21 - 60S ribosomal protein L21 - Rattus norvegicus (Rat) - Rpl21 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000180.1.170 Q8IVH2 FOXP4_HUMAN 95.401 0.98105 1.00882 FOXP4 - Forkhead box protein P4 - Homo sapiens (Human) - FOXP4 gene Transcriptional repressor that represses lung-specific expression. Taurus_UMD|evm.model.AC_000180.1.171 Q99750 MDFI_HUMAN 88.664 0.991935 1.00813 MDFI - MyoD family inhibitor - Homo sapiens (Human) - MDFI gene Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity). Taurus_UMD|evm.model.AC_000180.1.172 P19484 TFEB_HUMAN 94.154 0.995825 1.0063 TFEB - Transcription factor EB - Homo sapiens (Human) - TFEB gene Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22576015, PubMed:22343943, PubMed:22692423, PubMed:30120233, PubMed:31672913). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22576015, PubMed:22343943, PubMed:22692423). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22576015, PubMed:22343943, PubMed:22692423). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus or S.enterica, acting downstream of protein kinase D (PKD), probably by regulating cytokine and chemokine expression (By similarity). Taurus_UMD|evm.model.AC_000180.1.173 Q9GMY3 PEPC_RHIFE 84.365 0.644211 1.22108 PGC - Gastricsin precursor - Rhinolophus ferrumequinum (Greater horseshoe bat) - PGC gene Hydrolyzes a variety of proteins. Taurus_UMD|evm.model.AC_000180.1.174 O43559 FRS3_HUMAN 93.737 0.995968 1.00813 FRS3 - Fibroblast growth factor receptor substrate 3 - Homo sapiens (Human) - FRS3 gene Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2. Taurus_UMD|evm.model.AC_000180.1.175 Q2TBC4 PRIC4_HUMAN 71.965 0.877863 1.14244 PRICKLE4 - Prickle-like protein 4 - Homo sapiens (Human) - PRICKLE4 gene adherens junction, filamentous actin, nucleus, stress fiber, Z disc, actin binding, muscle alpha-actinin binding, actin cytoskeleton organization, heart development, muscle structure development Taurus_UMD|evm.model.AC_000180.1.176 Q56JY4 TOM6_BOVIN 95.556 0.611111 0.972973 TOMM6 - Mitochondrial import receptor subunit TOM6 homolog - Bos taurus (Bovine) - TOMM6 gene mitochondrion Taurus_UMD|evm.model.AC_000180.1.177 Q70CQ1 UBP49_HUMAN 91.279 0.995614 0.994186 USP49 - Ubiquitin carboxyl-terminal hydrolase 49 - Homo sapiens (Human) - USP49 gene Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons. Taurus_UMD|evm.model.AC_000180.1.178 Q9H944 MED20_HUMAN 98.558 0.962791 1.01415 MED20 - Mediator of RNA polymerase II transcription subunit 20 - Homo sapiens (Human) - MED20 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Taurus_UMD|evm.model.AC_000180.1.179 Q5E9N0 BYST_BOVIN 100.000 0.995413 1.0023 BYSL - Bystin - Bos taurus (Bovine) - BYSL gene Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. Taurus_UMD|evm.model.AC_000180.1.180 Q3MHH5 CCND3_BOVIN 99.658 0.993174 1.00342 CCND3 - G1/S-specific cyclin-D3 - Bos taurus (Bovine) - CCND3 gene Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). Taurus_UMD|evm.model.AC_000180.1.181 A7MAZ4 TAF8_BOVIN 99.353 0.740385 1.34194 TAF8 - Transcription initiation factor TFIID subunit 8 - Bos taurus (Bovine) - TAF8 gene Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). Taurus_UMD|evm.model.AC_000180.1.182 Q91Z58 CF132_MOUSE 84.211 0.0389884 0.786899 Uncharacterized protein C6orf132 homolog - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000180.1.183 X6R8D5 GUCNB_HUMAN 86.239 0.8 1.06299 GUCA1ANB - Putative uncharacterized protein GUCA1ANB - Homo sapiens (Human) - GUCA1ANB gene Taurus_UMD|evm.model.AC_000180.1.184 P46065 GUC1A_BOVIN 100.000 0.990291 1.00488 GUCA1A - Guanylyl cyclase-activating protein 1 - Bos taurus (Bovine) - GUCA1A gene Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:7520254, PubMed:8626484, PubMed:9651312, PubMed:26703466). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (PubMed:7520254, PubMed:8626484). May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity). Taurus_UMD|evm.model.AC_000180.1.185 P51177 GUC1B_BOVIN 99.510 0.990244 1.0049 GUCA1B - Guanylyl cyclase-activating protein 2 - Bos taurus (Bovine) - GUCA1B gene Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (PubMed:7665624). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (PubMed:9651312). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity). Taurus_UMD|evm.model.AC_000180.1.186 P82670 RT10_BOVIN 100.000 0.990099 1.00498 MRPS10 - 28S ribosomal protein S10, mitochondrial - Bos taurus (Bovine) - MRPS10 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion Taurus_UMD|evm.model.AC_000180.1.187 Q96PN7 TREF1_HUMAN 87.469 0.998347 1.00833 TRERF1 - Transcriptional-regulating factor 1 - Homo sapiens (Human) - TRERF1 gene Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. Taurus_UMD|evm.model.AC_000180.1.189 Q8IWV8 UBR2_HUMAN 92.426 0.998862 1.00114 UBR2 - E3 ubiquitin-protein ligase UBR2 - Homo sapiens (Human) - UBR2 gene E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:15548684, PubMed:20835242). Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A (By similarity). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (PubMed:20298436). Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (By similarity). Catalyzes ubiquitination and degradation of the N-terminal part of NLRP1 following NLRP1 activation by pathogens and other damage-associated signals: ubiquitination promotes degradation of the N-terminal part and subsequent release of the cleaved C-terminal part of NLRP1, which polymerizes and forms the NLRP1 inflammasome followed by host cell pyroptosis (By similarity). Taurus_UMD|evm.model.AC_000180.1.190 P17810 PRPH2_BOVIN 100.000 0.994236 1.00289 PRPH2 - Peripherin-2 - Bos taurus (Bovine) - PRPH2 gene Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (PubMed:24196967). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Taurus_UMD|evm.model.AC_000180.1.191 Q3SZE9 TBCC_BOVIN 100.000 0.99422 1.0029 TBCC - Tubulin-specific chaperone C - Bos taurus (Bovine) - TBCC gene Tubulin-folding protein; involved in the final step of the tubulin folding pathway. Taurus_UMD|evm.model.AC_000180.1.192 Q6AI39 BICRL_HUMAN 89.410 0.962547 0.989805 BICRAL - BRD4-interacting chromatin-remodeling complex-associated protein-like - Homo sapiens (Human) - BICRAL gene Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Taurus_UMD|evm.model.AC_000180.1.193 A5GFQ0 RL7L_PIG 93.117 0.957198 1.04049 RPL7L1 - 60S ribosomal protein L7-like 1 - Sus scrofa (Pig) - RPL7L1 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000180.1.194 Q9D727 CF226_MOUSE 66.667 0.517544 1 Uncharacterized protein C6orf226 homolog - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000180.1.195 Q0P5N1 CNPY3_BOVIN 100.000 0.488069 1.63475 CNPY3 - Protein canopy homolog 3 precursor - Bos taurus (Bovine) - CNPY3 gene Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). Taurus_UMD|evm.model.AC_000180.1.196 Q14749 GNMT_HUMAN 92.857 0.936102 1.06102 GNMT - Glycine N-methyltransferase - Homo sapiens (Human) - GNMT gene Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine. Taurus_UMD|evm.model.AC_000180.1.197 Q13608 PEX6_HUMAN 91.633 0.997961 1.00102 PEX6 - Peroxisome assembly factor 2 - Homo sapiens (Human) - PEX6 gene Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Taurus_UMD|evm.model.AC_000180.1.198 Q28653 2A5D_RABIT 99.141 0.963394 1.0256 PPP2R5D - Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform - Oryctolagus cuniculus (Rabbit) - PPP2R5D gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Taurus_UMD|evm.model.AC_000180.1.199 Q29407 MEA1_BOVIN 100.000 0.988571 1.00575 MEA1 - Male-enhanced antigen 1 - Bos taurus (Bovine) - MEA1 gene May play an important role in spermatogenesis and/or testis development. Taurus_UMD|evm.model.AC_000180.1.200 Q58CV6 KLDC3_BOVIN 100.000 0.994778 1.00262 KLHDC3 - Kelch domain-containing protein 3 - Bos taurus (Bovine) - KLHDC3 gene May be involved in meiotic recombination process. Taurus_UMD|evm.model.AC_000180.1.201 A6QNR1 RRP36_BOVIN 100.000 0.836177 1.19106 RRP36 - Ribosomal RNA processing protein 36 homolog - Bos taurus (Bovine) - RRP36 gene Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Taurus_UMD|evm.model.AC_000180.1.202 Q2TA12 RM02_BOVIN 100.000 0.147074 6.53268 MRPL2 - 39S ribosomal protein L2, mitochondrial precursor - Bos taurus (Bovine) - MRPL2 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, RNA binding, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000180.1.204 Q2HJJ0 KLC4_BOVIN 93.994 0.996575 0.948052 KLC4 - Kinesin light chain 4 - Bos taurus (Bovine) - KLC4 gene Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). Taurus_UMD|evm.model.AC_000180.1.205 Q13308 PTK7_HUMAN 94.112 0.998133 1.00093 PTK7 - Inactive tyrosine-protein kinase 7 precursor - Homo sapiens (Human) - PTK7 gene Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Taurus_UMD|evm.model.AC_000180.1.206 P11831 SRF_HUMAN 97.839 0.996078 1.00394 SRF - Serum response factor - Homo sapiens (Human) - SRF gene SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. Taurus_UMD|evm.model.AC_000180.1.207 Q8IWT3 CUL9_HUMAN 88.699 0.994045 1.00079 CUL9 - Cullin-9 - Homo sapiens (Human) - CUL9 gene Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328). Taurus_UMD|evm.model.AC_000180.1.208 O43598 DNPH1_HUMAN 78.981 0.917722 0.908046 DNPH1 - 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 - Homo sapiens (Human) - DNPH1 gene Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. Taurus_UMD|evm.model.AC_000180.1.209 Q6PCN3 TTBK1_MOUSE 97.738 0.436508 0.770642 Ttbk1 - Tau-tubulin kinase 1 - Mus musculus (Mouse) - Ttbk1 gene Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU (By similarity). Taurus_UMD|evm.model.AC_000180.1.210 A6QLW8 S22A7_BOVIN 99.817 0.99635 1.00183 SLC22A7 - Solute carrier family 22 member 7 - Bos taurus (Bovine) - SLC22A7 gene Mediates sodium-independent multispecific organic anion transport. Taurus_UMD|evm.model.AC_000180.1.211 Q6Q6R5 CRIP3_HUMAN 92.432 0.897561 0.9447 CRIP3 - Cysteine-rich protein 3 - Homo sapiens (Human) - CRIP3 gene Taurus_UMD|evm.model.AC_000180.1.212 Q5VUA4 ZN318_HUMAN 83.174 0.991736 0.955682 ZNF318 - Zinc finger protein 318 - Homo sapiens (Human) - ZNF318 gene Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. Taurus_UMD|evm.model.AC_000180.1.213 Q5T3U5 MRP7_HUMAN 89.725 0.989362 1.00804 ABCC10 - ATP-binding cassette sub-family C member 10 - Homo sapiens (Human) - ABCC10 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:12527806, PubMed:15256465). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel (PubMed:15256465, PubMed:23087055). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP (PubMed:12527806). Taurus_UMD|evm.model.AC_000180.1.214 A4FV93 DLK2_BOVIN 100.000 0.938575 1.06266 DLK2 - Protein delta homolog 2 precursor - Bos taurus (Bovine) - DLK2 gene Regulates adipogenesis. Taurus_UMD|evm.model.AC_000180.1.215 Q5JTD0 TJAP1_HUMAN 89.267 0.780314 1.25853 TJAP1 - Tight junction-associated protein 1 - Homo sapiens (Human) - TJAP1 gene Plays a role in regulating the structure of the Golgi apparatus. Taurus_UMD|evm.model.AC_000180.1.216 Q5JTD7 LRC73_HUMAN 98.101 0.707865 1.40823 LRRC73 - Leucine-rich repeat-containing protein 73 - Homo sapiens (Human) - LRRC73 gene Taurus_UMD|evm.model.AC_000180.1.217 Q9GZM5 YIPF3_HUMAN 97.429 0.994253 0.994286 YIPF3 - Protein YIPF3 - Homo sapiens (Human) - YIPF3 gene Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis. Taurus_UMD|evm.model.AC_000180.1.218 Q32L22 RPAC1_BOVIN 100.000 0.994236 1.00289 POLR1C - DNA-directed RNA polymerases I and III subunit RPAC1 - Bos taurus (Bovine) - POLR1C gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Taurus_UMD|evm.model.AC_000180.1.219 Q9HAV4 XPO5_HUMAN 94.183 0.985593 0.980066 XPO5 - Exportin-5 - Homo sapiens (Human) - XPO5 gene Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner. Taurus_UMD|evm.model.AC_000180.1.220 Q9Y253 POLH_HUMAN 82.028 0.996923 0.911641 POLH - DNA polymerase eta - Homo sapiens (Human) - POLH gene DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906, PubMed:24553286, PubMed:16357261). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). Taurus_UMD|evm.model.AC_000180.1.221 Q9BX10 GTPB2_HUMAN 98.505 0.996683 1.00166 GTPBP2 - GTP-binding protein 2 - Homo sapiens (Human) - GTPBP2 gene extracellular region, platelet alpha granule lumen, identical protein binding, translation elongation factor activity, platelet degranulation, translational elongation Taurus_UMD|evm.model.AC_000180.1.222 Q15013 MD2BP_HUMAN 85.766 0.964664 1.03285 MAD2L1BP - MAD2L1-binding protein - Homo sapiens (Human) - MAD2L1BP gene May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. Taurus_UMD|evm.model.AC_000180.1.223 Q2KIU7 RSPH9_BOVIN 100.000 0.99278 1.00362 RSPH9 - Radial spoke head protein 9 homolog - Bos taurus (Bovine) - RSPH9 gene Component of the axonemal radial spoke head which plays an important role in ciliary motility (By similarity). Essential for both the radial spoke head assembly and the central pair microtubule stability in ependymal motile cilia (By similarity). Required for motility of olfactory and neural cilia and for the structural integrity of ciliary axonemes in both 9+0 and 9+2 motile cilia (By similarity). Taurus_UMD|evm.model.AC_000180.1.224 P82919 RT18A_BOVIN 99.490 0.989848 1.0051 MRPS18A - 28S ribosomal protein S18a, mitochondrial precursor - Bos taurus (Bovine) - MRPS18A gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit rRNA binding, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000180.1.225 P15691 VEGFA_BOVIN 100.000 0.614754 0.642105 VEGFA - Vascular endothelial growth factor A precursor - Bos taurus (Bovine) - VEGFA gene Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Taurus_UMD|evm.model.AC_000180.1.226 Q9MYV3 VEGFA_CANLF 94.495 0.981818 0.514019 VEGFA - Vascular endothelial growth factor A precursor - Canis lupus familiaris (Dog) - VEGFA gene Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Taurus_UMD|evm.model.AC_000180.1.227 Q4R642 DRC5_MACFA 76.531 0.764706 0.508982 TCTE1 - Dynein regulatory complex subunit 5 - Macaca fascicularis (Crab-eating macaque) - TCTE1 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility. Taurus_UMD|evm.model.AC_000180.1.228 Q5JTZ9 SYAM_HUMAN 87.342 0.829787 0.0954315 AARS2 - Alanine--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - AARS2 gene Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Taurus_UMD|evm.model.AC_000180.1.229 Q1JQ99 RM14_BOVIN 100.000 0.986301 1.0069 MRPL14 - 39S ribosomal protein L14, mitochondrial precursor - Bos taurus (Bovine) - MRPL14 gene May form part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1, intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation. Taurus_UMD|evm.model.AC_000180.1.230 Q5T3F8 CSCL2_HUMAN 97.957 0.914002 1.09014 TMEM63B - CSC1-like protein 2 - Homo sapiens (Human) - TMEM63B gene Acts as an osmosensitive calcium-permeable cation channel (By similarity). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion (By similarity). Taurus_UMD|evm.model.AC_000180.1.231 Q9UMQ6 CAN11_HUMAN 79.743 0.925631 1.01894 CAPN11 - Calpain-11 - Homo sapiens (Human) - CAPN11 gene Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Taurus_UMD|evm.model.AC_000180.1.232 A0A1B0GTQ4 MYMX_HUMAN 87.500 0.741176 1.0119 MYMX - Protein myomixer - Homo sapiens (Human) - MYMX gene Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Involved in membrane fusion downstream of the lipid mixing step mediated by MYMK. Acts by generating membrane stresses via its extracellular C-terminus, leading to drive fusion pore formation. Acts independently of MYMK. Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers. Taurus_UMD|evm.model.AC_000180.1.233 Q99808 S29A1_HUMAN 86.842 0.754561 1.32237 SLC29A1 - Equilibrative nucleoside transporter 1 - Homo sapiens (Human) - SLC29A1 gene Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs). Taurus_UMD|evm.model.AC_000180.1.234 Q76LV1 HS90B_BOVIN 92.720 0.961385 1.03729 HSP90AB1 - Heat shock protein HSP 90-beta - Bos taurus (Bovine) - HSP90AB1 gene Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10. Taurus_UMD|evm.model.AC_000180.1.235 Q8TB61 S35B2_HUMAN 93.764 0.995392 1.00463 SLC35B2 - Adenosine 3'-phospho 5'-phosphosulfate transporter 1 - Homo sapiens (Human) - SLC35B2 gene Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Taurus_UMD|evm.model.AC_000180.1.236 O00221 IKBE_HUMAN 87.845 0.99449 0.726 NFKBIE - NF-kappa-B inhibitor epsilon - Homo sapiens (Human) - NFKBIE gene Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. Taurus_UMD|evm.model.AC_000180.1.237 Q8IW70 T151B_HUMAN 97.913 0.88255 1.053 TMEM151B - Transmembrane protein 151B - Homo sapiens (Human) - TMEM151B gene Taurus_UMD|evm.model.AC_000180.1.238 Q4R642 DRC5_MACFA 93.333 0.764103 0.389222 TCTE1 - Dynein regulatory complex subunit 5 - Macaca fascicularis (Crab-eating macaque) - TCTE1 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility. Taurus_UMD|evm.model.AC_000180.1.241 O75486 SUPT3_HUMAN 94.444 0.929878 1.0347 SUPT3H - Transcription initiation protein SPT3 homolog - Homo sapiens (Human) - SUPT3H gene Probable transcriptional activator. Taurus_UMD|evm.model.AC_000180.1.242 Q9Z2J9 RUNX2_RAT 100.000 0.246377 2.2156 Runx2 - Runt-related transcription factor 2 - Rattus norvegicus (Rat) - Runx2 gene Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Taurus_UMD|evm.model.AC_000180.1.244 P35526 CLIC5_BOVIN 100.000 0.630435 0.421053 CLIC5 - Chloride intracellular channel protein 5 - Bos taurus (Bovine) - CLIC5 gene Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Taurus_UMD|evm.model.AC_000180.1.245 P35526 CLIC5_BOVIN 96.618 0.927928 0.508009 CLIC5 - Chloride intracellular channel protein 5 - Bos taurus (Bovine) - CLIC5 gene Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Taurus_UMD|evm.model.AC_000180.1.246 A2VDP5 ENPP4_BOVIN 100.000 0.995595 1.00221 ENPP4 - Bis(5'-adenosyl)-triphosphatase ENPP4 precursor - Bos taurus (Bovine) - ENPP4 gene Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors (By similarity). Taurus_UMD|evm.model.AC_000180.1.247 Q9UJA9 ENPP5_HUMAN 85.744 0.995816 1.0021 ENPP5 - Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 precursor - Homo sapiens (Human) - ENPP5 gene Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates. Lacks lysopholipase D activity. May play a role in neuronal cell communication. Taurus_UMD|evm.model.AC_000180.1.249 Q3ZC15 RCAN2_BOVIN 100.000 0.989899 1.00508 RCAN2 - Calcipressin-2 - Bos taurus (Bovine) - RCAN2 gene Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity). Taurus_UMD|evm.model.AC_000180.1.250 Q9NYL5 CP39A_HUMAN 74.573 0.993197 0.940299 CYP39A1 - 24-hydroxycholesterol 7-alpha-hydroxylase precursor - Homo sapiens (Human) - CYP39A1 gene A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis (PubMed:25201972, PubMed:10748047). Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver (PubMed:25201972, PubMed:10748047). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25201972, PubMed:10748047). Taurus_UMD|evm.model.AC_000180.1.251 O95847 UCP4_HUMAN 94.737 0.993827 1.0031 SLC25A27 - Mitochondrial uncoupling protein 4 - Homo sapiens (Human) - SLC25A27 gene UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain. Taurus_UMD|evm.model.AC_000180.1.253 O60522 TDRD6_HUMAN 76.372 0.994269 0.999046 TDRD6 - Tudor domain-containing protein 6 - Homo sapiens (Human) - TDRD6 gene Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation (By similarity). Essential for RNA-dependent helicase UPF1 localization to chromatoid body, for UPF1-UPF2 and UPF1-DDX4 interactions which are required for mRNA degradation, using the extended 3' UTR-triggered nonsense-mediated mRNA decay (NMD) pathway. Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through interaction with arginine N-methyltransferase PRMT5 and symmetrically arginine dimethylated SNRPB (small nuclear ribonucleoprotein-associated protein) (By similarity). Taurus_UMD|evm.model.AC_000180.1.254 Q28017 PAFA_BOVIN 99.550 0.995506 1.00225 PLA2G7 - Platelet-activating factor acetylhydrolase precursor - Bos taurus (Bovine) - PLA2G7 gene Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (By similarity). At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (By similarity). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position. Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (By similarity). Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent proinflammatory signaling lipid that acts through PTAFR on various innate immune cells (By similarity). Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled proinflammatory effects (By similarity). As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (By similarity). Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (By similarity). Taurus_UMD|evm.model.AC_000180.1.255 B4E2M5 ANR66_HUMAN 81.538 0.979798 0.788845 ANKRD66 - Ankyrin repeat domain-containing protein 66 - Homo sapiens (Human) - ANKRD66 gene Taurus_UMD|evm.model.AC_000180.1.256 Q16819 MEP1A_HUMAN 80.641 0.997297 0.991957 MEP1A - Meprin A subunit alpha precursor - Homo sapiens (Human) - MEP1A gene extracellular exosome, extracellular space, integral component of plasma membrane, meprin A complex, metalloendopeptidase activity Taurus_UMD|evm.model.AC_000180.1.257 Q8IZF2 AGRF5_HUMAN 72.376 0.987717 1.02823 ADGRF5 - Adhesion G protein-coupled receptor F5 precursor - Homo sapiens (Human) - ADGRF5 gene Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function. Taurus_UMD|evm.model.AC_000180.1.258 Q5T601 AGRF1_HUMAN 69.298 0.952681 1.04505 ADGRF1 - Adhesion G-protein coupled receptor F1 precursor - Homo sapiens (Human) - ADGRF1 gene Orphan receptor. Taurus_UMD|evm.model.AC_000180.1.259 Q5R8S7 PPIA_PONPY 81.034 0.857143 0.806061 PPIA - Peptidyl-prolyl cis-trans isomerase A - Pongo pygmaeus (Bornean orangutan) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Taurus_UMD|evm.model.AC_000180.1.260 O75509 TNR21_HUMAN 90.534 0.996937 0.996947 TNFRSF21 - Tumor necrosis factor receptor superfamily member 21 precursor - Homo sapiens (Human) - TNFRSF21 gene Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Taurus_UMD|evm.model.AC_000180.1.261 Q9Y5K6 CD2AP_HUMAN 86.936 0.996865 0.998435 CD2AP - CD2-associated protein - Homo sapiens (Human) - CD2AP gene Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). Taurus_UMD|evm.model.AC_000180.1.262 Q8IZF7 AGRF2_HUMAN 79.062 0.883929 0.949153 ADGRF2 - Adhesion G-protein coupled receptor F2 - Homo sapiens (Human) - ADGRF2 gene Orphan receptor. Taurus_UMD|evm.model.AC_000180.1.263 Q8IZF3 AGRF4_HUMAN 80.897 0.99711 0.995683 ADGRF4 - Adhesion G protein-coupled receptor F4 precursor - Homo sapiens (Human) - ADGRF4 gene Orphan receptor. Taurus_UMD|evm.model.AC_000180.1.264 Q6U736 OPN5_HUMAN 94.163 0.850498 0.850282 OPN5 - Opsin-5 - Homo sapiens (Human) - OPN5 gene G-protein coupled receptor which selectively activates G(i) type G proteins via ultraviolet A (UVA) light-mediated activation in the retina (By similarity). Preferentially binds the chromophore 11-cis retinal and is a bistable protein that displays emission peaks at 380 nm (UVA light) and 470 nm (blue light) (PubMed:22043319). Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake (By similarity). Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock (By similarity). Acts as a circadian photoreceptor in the outer ear, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle (By similarity). Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling (By similarity). Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels (By similarity). Taurus_UMD|evm.model.AC_000180.1.265 Q6ZW05 PTHD4_HUMAN 98.039 0.996086 0.604019 PTCHD4 - Patched domain-containing protein 4 - Homo sapiens (Human) - PTCHD4 gene Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells. Taurus_UMD|evm.model.AC_000180.1.266 Q6ZW05 PTHD4_HUMAN 96.296 0.952663 0.199764 PTCHD4 - Patched domain-containing protein 4 - Homo sapiens (Human) - PTCHD4 gene Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells. Taurus_UMD|evm.model.AC_000180.1.267 Q6ZW05 PTHD4_HUMAN 99.200 0.610837 0.239953 PTCHD4 - Patched domain-containing protein 4 - Homo sapiens (Human) - PTCHD4 gene Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells. Taurus_UMD|evm.model.AC_000180.1.268 Q58DB0 PLD3B_BOVIN 97.196 0.773723 0.706186 PRELID3B - PRELI domain containing protein 3B - Bos taurus (Bovine) - PRELID3B gene mitochondrial intermembrane space, phosphatidic acid transfer activity, phospholipid transport Taurus_UMD|evm.model.AC_000180.1.269 Q9GK13 MUTA_BOVIN 98.133 0.997337 1.00133 MMUT - Methylmalonyl-CoA mutase, mitochondrial precursor - Bos taurus (Bovine) - MMUT gene Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. Taurus_UMD|evm.model.AC_000180.1.270 Q7L2Z9 CENPQ_HUMAN 74.074 0.992593 1.00746 CENPQ - Centromere protein Q - Homo sapiens (Human) - CENPQ gene Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). Taurus_UMD|evm.model.AC_000180.1.271 Q5SZD4 GLYL3_HUMAN 82.230 0.989583 1 GLYATL3 - Glycine N-acyltransferase-like protein 3 - Homo sapiens (Human) - GLYATL3 gene Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway. Taurus_UMD|evm.model.AC_000180.1.272 Q5SZD1 CF141_HUMAN 55.721 0.989418 0.77459 C6orf141 - Uncharacterized protein C6orf141 - Homo sapiens (Human) - C6orf141 gene blastocyst hatching Taurus_UMD|evm.model.AC_000180.1.273 Q9GKN7 RHAG_BOVIN 99.765 0.995316 1.00235 RHAG - Ammonium transporter Rh type A - Bos taurus (Bovine) - RHAG gene May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Involved in ammonia transport across the erythrocyte membrane. Seems to act as a monovalent cation transport. Taurus_UMD|evm.model.AC_000180.1.274 P16562 CRIS2_HUMAN 81.557 0.991837 1.00823 CRISP2 - Cysteine-rich secretory protein 2 precursor - Homo sapiens (Human) - CRISP2 gene May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. Taurus_UMD|evm.model.AC_000180.1.275 O19010 CRIS3_HORSE 54.198 0.603774 0.865306 CRISP3 - Cysteine-rich secretory protein 3 precursor - Equus caballus (Horse) - CRISP3 gene extracellular region, extracellular space, specific granule, cell-cell adhesion, fertilization, spermatogenesis Taurus_UMD|evm.model.AC_000180.1.276 P68105 EF1A1_RABIT 94.805 0.99568 1.00216 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000180.1.277 Q8MIF7 PGK2_HORSE 93.285 0.995215 1.0024 PGK2 - Phosphoglycerate kinase 2 - Equus caballus (Horse) - PGK2 gene Essential for sperm motility and male fertility but is not required for the completion of spermatogenesis. Taurus_UMD|evm.model.AC_000180.1.278 P54107 CRIS1_HUMAN 65.801 0.853933 1.07229 CRISP1 - Cysteine-rich secretory protein 1 precursor - Homo sapiens (Human) - CRISP1 gene May have a role in sperm-egg fusion and maturation. Taurus_UMD|evm.model.AC_000180.1.279 Q30KQ6 DB114_HUMAN 58.209 0.969231 0.942029 DEFB114 - Beta-defensin 114 precursor - Homo sapiens (Human) - DEFB114 gene Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. Taurus_UMD|evm.model.AC_000180.1.280 Q30KL5 DB112_PANTR 47.561 0.663934 1.07965 DEFB112 - Beta-defensin 112 precursor - Pan troglodytes (Chimpanzee) - DEFB112 gene Has antibacterial activity. Taurus_UMD|evm.model.AC_000180.1.281 Q7Z6R9 AP2D_HUMAN 81.195 0.994609 0.820796 TFAP2D - Transcription factor AP-2-delta - Homo sapiens (Human) - TFAP2D gene Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity). Taurus_UMD|evm.model.AC_000180.1.282 Q92481 AP2B_HUMAN 100.000 0.995556 0.978261 TFAP2B - Transcription factor AP-2-beta - Homo sapiens (Human) - TFAP2B gene Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. Taurus_UMD|evm.model.AC_000180.1.285 E2RK30 PKHD1_CANLF 80.000 0.401441 1.02234 PKHD1 - Fibrocystin precursor - Canis lupus familiaris (Dog) - PKHD1 gene Promotes ciliogenesis in renal epithelial cells and therefore participates in the tubules formation and/ or ensures the maintenance of the architecture of the lumen of the kidney (By similarity). Has an impact on cellular symmetry by ensuring correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly and by maintaining oriented cell division (OCD) during tubular elongation through planar cell polarity (PCP) pathway (By similarity). During epithelial cell morphogenesis regulates also cell-cell and cell-matrix adhesion and participates in cell motility (PubMed:32698519, PubMed:31398719). Promotes cell-cell contact through the positive regulation of PTK2 kinase activity leading to either positive regulation of epithelial cell proliferation through the HRAS/RAF1 pathways, or negative regulation of apoptosis through the PDK1/AKT1 pathway (By similarity). May act in collecting-duct and biliary differentiation (By similarity). May participate in the regulation of the cholangiocytes proliferation and the CCN2 production in an CXCL8-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000180.1.286 Q6WV90 H4_MYTGA 97.872 0.638889 0.699029 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000180.1.287 Q687Y7 IL17_BOVIN 100.000 0.635983 1.56209 IL17A - Interleukin-17A precursor - Bos taurus (Bovine) - IL17A gene Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines. In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells. Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance. Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation. Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis. As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release. In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung. Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense. Taurus_UMD|evm.model.AC_000180.1.288 Q7TNI7 IL17F_MOUSE 64.474 0.853801 1.06211 Il17f - Interleukin-17F precursor - Mus musculus (Mouse) - Il17f gene Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:23255360, PubMed:18025225, PubMed:19144317). IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:17911633, PubMed:15477493, PubMed:18025225). IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation (PubMed:18025225, PubMed:23255360). As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (PubMed:18025225). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317). IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:28813677). Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (PubMed:28813677). Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (PubMed:32076265). Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes (PubMed:29915298). Taurus_UMD|evm.model.AC_000180.1.289 A4FUD9 MCM3_BOVIN 99.876 0.997528 1.00124 MCM3 - DNA replication licensing factor MCM3 - Bos taurus (Bovine) - MCM3 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000180.1.290 O46415 FRIL_BOVIN 68.333 0.982456 0.651429 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000180.1.291 Q8K003 TMA7_MOUSE 98.438 0.969231 1.01562 Tma7 - Translation machinery-associated protein 7 - Mus musculus (Mouse) - Tma7 gene cytoplasmic translation Taurus_UMD|evm.model.AC_000180.1.292 Q865K9 MPRB_PIG 90.960 0.994366 1.00282 PAQR8 - Membrane progestin receptor beta - Sus scrofa (Pig) - PAQR8 gene Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity). Taurus_UMD|evm.model.AC_000180.1.293 Q5JVL4 EFHC1_HUMAN 89.688 0.99688 1.00156 EFHC1 - EF-hand domain-containing protein 1 - Homo sapiens (Human) - EFHC1 gene Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization (PubMed:19734894, PubMed:28370826). Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (PubMed:22926142). May enhance calcium influx through CACNA1E and stimulate programmed cell death (PubMed:15258581). Taurus_UMD|evm.model.AC_000180.1.294 Q15035 TRAM2_HUMAN 95.135 0.994609 1.0027 TRAM2 - Translocating chain-associated membrane protein 2 - Homo sapiens (Human) - TRAM2 gene Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293). Taurus_UMD|evm.model.AC_000180.1.295 P56982 TM14A_BOVIN 100.000 0.514286 1.76768 TMEM14A - Transmembrane protein 14A - Bos taurus (Bovine) - TMEM14A gene Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Taurus_UMD|evm.model.AC_000180.1.296 O18879 GSTA2_BOVIN 100.000 0.991071 1.00448 GSTA2 - Glutathione S-transferase A2 - Bos taurus (Bovine) - GSTA2 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Taurus_UMD|evm.model.AC_000180.1.297 O18879 GSTA2_BOVIN 91.209 0.493188 1.64574 GSTA2 - Glutathione S-transferase A2 - Bos taurus (Bovine) - GSTA2 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Taurus_UMD|evm.model.AC_000180.1.298 Q28035 GSTA1_BOVIN 86.473 0.980952 0.945946 GSTA1 - Glutathione S-transferase A1 - Bos taurus (Bovine) - GSTA1 gene Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid. Taurus_UMD|evm.model.AC_000180.1.299 P14942 GSTA4_RAT 84.685 0.991031 1.0045 Gsta4 - Glutathione S-transferase alpha-4 - Rattus norvegicus (Rat) - Gsta4 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Taurus_UMD|evm.model.AC_000180.1.300 Q5E9G0 GSTA4_BOVIN 100.000 0.991031 1.0045 GSTA4 - Glutathione S-transferase A4 - Bos taurus (Bovine) - GSTA4 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Taurus_UMD|evm.model.AC_000180.1.301 Q9UPZ9 CILK1_HUMAN 91.456 0.99682 0.995253 CILK1 - Serine/threonine-protein kinase ICK - Homo sapiens (Human) - CILK1 gene Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity). Taurus_UMD|evm.model.AC_000180.1.302 Q3ZBT2 FBX9_BOVIN 99.544 0.995455 1.00686 FBXO9 - F-box only protein 9 - Bos taurus (Bovine) - FBXO9 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity). Taurus_UMD|evm.model.AC_000180.1.303 Q9NP62 GCM1_HUMAN 74.312 0.995392 0.995413 GCM1 - Chorion-specific transcription factor GCMa - Homo sapiens (Human) - GCM1 gene Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). Taurus_UMD|evm.model.AC_000180.1.304 Q2KJD9 ELOV5_BOVIN 100.000 0.993333 1.00334 ELOVL5 - Elongation of very long chain fatty acids protein 5 - Bos taurus (Bovine) - ELOVL5 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity). Taurus_UMD|evm.model.AC_000180.1.305 P15981 HA2D_PIG 75.984 0.732733 1.30588 SLA class II histocompatibility antigen, DQ haplotype D alpha chain precursor - Sus scrofa (Pig) Taurus_UMD|evm.model.AC_000180.1.306 Q9TVC8 HB21_BOVIN 83.398 0.886598 1.11494 BoLA-DQB - BoLa class II histocompatibility antigen, DQB*0101 beta chain precursor - Bos taurus (Bovine) - BoLA-DQB gene Taurus_UMD|evm.model.AC_000180.1.307 P15980 HA2C_PIG 80.392 0.992188 1.00787 SLA class II histocompatibility antigen, DQ haplotype C alpha chain precursor - Sus scrofa (Pig) Taurus_UMD|evm.model.AC_000180.1.308 Q9TVC8 HB21_BOVIN 90.526 0.5875 0.613027 BoLA-DQB - BoLa class II histocompatibility antigen, DQB*0101 beta chain precursor - Bos taurus (Bovine) - BoLA-DQB gene Taurus_UMD|evm.model.AC_000180.1.309 P15981 HA2D_PIG 88.435 0.843931 0.678431 SLA class II histocompatibility antigen, DQ haplotype D alpha chain precursor - Sus scrofa (Pig) Taurus_UMD|evm.model.AC_000180.1.310 P18470 HB2D_CANLF 80.827 0.992509 1.00376 DLA class II histocompatibility antigen, DR-1 beta chain precursor - Canis lupus familiaris (Dog) Taurus_UMD|evm.model.AC_000180.1.311 P01911 DRB1_HUMAN 56.111 0.638614 0.759398 HLA-DRB1 - HLA class II histocompatibility antigen, DRB1 beta chain precursor - Homo sapiens (Human) - HLA-DRB1 gene A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:29884618, PubMed:22327072, PubMed:27591323, PubMed:8642306, PubMed:15265931, PubMed:31495665, PubMed:16148104). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed:17182262, PubMed:23783831). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819). Taurus_UMD|evm.model.AC_000180.1.312 Q30154 DRB5_HUMAN 75.330 0.584416 1.44737 HLA-DRB5 - HLA class II histocompatibility antigen, DR beta 5 chain precursor - Homo sapiens (Human) - HLA-DRB5 gene Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. Taurus_UMD|evm.model.AC_000180.1.313 Q30631 DRA_MACMU 80.709 0.992126 1 Mamu-DRA - Mamu class II histocompatibility antigen, DR alpha chain precursor - Macaca mulatta (Rhesus macaque) - Mamu-DRA gene Taurus_UMD|evm.model.AC_000180.1.314 Q9UIR0 BTNL2_HUMAN 70.659 0.785377 0.931868 BTNL2 - Butyrophilin-like protein 2 - Homo sapiens (Human) - BTNL2 gene Negative regulator of T-cell proliferation. Taurus_UMD|evm.model.AC_000180.1.315 Q13410 BT1A1_HUMAN 39.354 0.948529 1.03422 BTN1A1 - Butyrophilin subfamily 1 member A1 precursor - Homo sapiens (Human) - BTN1A1 gene May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). Taurus_UMD|evm.model.AC_000180.1.316 Q7TST0 BTNL1_MOUSE 55.403 0.99604 0.992141 Btnl1 - Butyrophilin-like protein 1 precursor - Mus musculus (Mouse) - Btnl1 gene cell surface, external side of plasma membrane, signaling receptor binding, extrathymic T cell selection, regulation of cytokine production, T cell receptor signaling pathway Taurus_UMD|evm.model.AC_000180.1.318 Q9TVC8 HB21_BOVIN 90.805 0.992366 1.00383 BoLA-DQB - BoLa class II histocompatibility antigen, DQB*0101 beta chain precursor - Bos taurus (Bovine) - BoLA-DQB gene Taurus_UMD|evm.model.AC_000180.1.319 Q9UIR0 BTNL2_HUMAN 66.076 0.628425 1.28352 BTNL2 - Butyrophilin-like protein 2 - Homo sapiens (Human) - BTNL2 gene Negative regulator of T-cell proliferation. Taurus_UMD|evm.model.AC_000180.1.320 P18892 BT1A1_BOVIN 53.591 0.9 0.380228 BTN1A1 - Butyrophilin subfamily 1 member A1 precursor - Bos taurus (Bovine) - BTN1A1 gene May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane. Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). Taurus_UMD|evm.model.AC_000180.1.321 Q13410 BT1A1_HUMAN 53.039 0.865385 0.395437 BTN1A1 - Butyrophilin subfamily 1 member A1 precursor - Homo sapiens (Human) - BTN1A1 gene May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). Taurus_UMD|evm.model.AC_000180.1.323 Q5SRN2 TSBP1_HUMAN 50.246 0.353765 1.01421 TSBP1 - Testis-expressed basic protein 1 - Homo sapiens (Human) - TSBP1 gene nucleus Taurus_UMD|evm.model.AC_000180.1.324 P97347 RPTN_MOUSE 23.684 0.502747 0.325581 Rptn - Repetin - Mus musculus (Mouse) - Rptn gene Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Taurus_UMD|evm.model.AC_000180.1.325 Q13410 BT1A1_HUMAN 44.211 0.627319 1.12738 BTN1A1 - Butyrophilin subfamily 1 member A1 precursor - Homo sapiens (Human) - BTN1A1 gene May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). Taurus_UMD|evm.model.AC_000180.1.326 Q7TST0 BTNL1_MOUSE 42.500 0.799087 0.860511 Btnl1 - Butyrophilin-like protein 1 precursor - Mus musculus (Mouse) - Btnl1 gene cell surface, external side of plasma membrane, signaling receptor binding, extrathymic T cell selection, regulation of cytokine production, T cell receptor signaling pathway Taurus_UMD|evm.model.AC_000180.1.327 P18892 BT1A1_BOVIN 55.932 0.75 0.296578 BTN1A1 - Butyrophilin subfamily 1 member A1 precursor - Bos taurus (Bovine) - BTN1A1 gene May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane. Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). Taurus_UMD|evm.model.AC_000180.1.328 Q99466 NOTC4_HUMAN 85.971 0.998996 0.995007 NOTCH4 - Neurogenic locus notch homolog protein 4 precursor - Homo sapiens (Human) - NOTCH4 gene Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity). Taurus_UMD|evm.model.AC_000180.1.329 Q9Y4H4 GPSM3_HUMAN 90.123 0.98773 1.01875 GPSM3 - G-protein-signaling modulator 3 - Homo sapiens (Human) - GPSM3 gene Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins. Taurus_UMD|evm.model.AC_000180.1.330 P40425 PBX2_HUMAN 99.302 0.99536 1.00233 PBX2 - Pre-B-cell leukemia transcription factor 2 - Homo sapiens (Human) - PBX2 gene Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. Taurus_UMD|evm.model.AC_000180.1.331 Q28173 RAGE_BOVIN 99.241 0.992443 0.954327 AGER - Advanced glycosylation end product-specific receptor precursor - Bos taurus (Bovine) - AGER gene Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Taurus_UMD|evm.model.AC_000180.1.332 Q99942 RNF5_HUMAN 98.889 0.98895 1.00556 RNF5 - E3 ubiquitin-protein ligase RNF5 - Homo sapiens (Human) - RNF5 gene Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses. Taurus_UMD|evm.model.AC_000180.1.333 Q95JH2 PLCA_BOVIN 100.000 0.993056 1.00348 AGPAT1 - 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha precursor - Bos taurus (Bovine) - AGPAT1 gene Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Taurus_UMD|evm.model.AC_000180.1.334 A5A8Y8 EGFL8_PIG 90.508 0.993243 1.00339 EGFL8 - Epidermal growth factor-like protein 8 precursor - Sus scrofa (Pig) - EGFL8 gene cell surface, extracellular region, signaling receptor binding, anatomical structure development Taurus_UMD|evm.model.AC_000180.1.335 Q1JQA0 PPT2_BOVIN 100.000 0.974359 1.02295 PPT2 - Lysosomal thioesterase PPT2 precursor - Bos taurus (Bovine) - PPT2 gene Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins (By similarity). Taurus_UMD|evm.model.AC_000180.1.336 Q99946 PRRT1_HUMAN 82.857 0.994286 1.14379 PRRT1 - Proline-rich transmembrane protein 1 - Homo sapiens (Human) - PRRT1 gene Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function. Regulates basal AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses. Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression. Taurus_UMD|evm.model.AC_000180.1.337 Q9UIM3 FKBPL_HUMAN 83.668 0.891192 1.10602 FKBPL - FK506-binding protein-like - Homo sapiens (Human) - FKBPL gene May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21. Taurus_UMD|evm.model.AC_000180.1.338 Q99941 ATF6B_HUMAN 85.915 0.997175 1.00711 ATF6B - Cyclic AMP-dependent transcription factor ATF-6 beta - Homo sapiens (Human) - ATF6B gene Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane (PubMed:11256944). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:11256944). Taurus_UMD|evm.model.AC_000180.1.339 P01030 CO4_BOVIN 98.904 0.926209 0.427174 C4 - Complement C4 precursor - Bos taurus (Bovine) - C4 gene Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). Taurus_UMD|evm.model.AC_000180.1.340 P00191 CP21A_BOVIN 90.047 0.526316 0.804435 CYP21 - Steroid 21-hydroxylase - Bos taurus (Bovine) - CYP21 gene A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids (PubMed:25855791, PubMed:22262854). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25855791, PubMed:22262854). Taurus_UMD|evm.model.AC_000180.1.341 P01030 CO4_BOVIN 98.701 0.014763 5.59565 C4 - Complement C4 precursor - Bos taurus (Bovine) - C4 gene Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). Taurus_UMD|evm.model.AC_000180.1.342 P01030 CO4_BOVIN 96.104 0.0389944 2.11848 C4 - Complement C4 precursor - Bos taurus (Bovine) - C4 gene Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). Taurus_UMD|evm.model.AC_000180.1.343 P00191 CP21A_BOVIN 98.148 0.269521 0.800403 CYP21 - Steroid 21-hydroxylase - Bos taurus (Bovine) - CYP21 gene A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids (PubMed:25855791, PubMed:22262854). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25855791, PubMed:22262854). Taurus_UMD|evm.model.AC_000180.1.344 P00191 CP21A_BOVIN 98.625 0.700483 0.834677 CYP21 - Steroid 21-hydroxylase - Bos taurus (Bovine) - CYP21 gene A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids (PubMed:25855791, PubMed:22262854). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25855791, PubMed:22262854). Taurus_UMD|evm.model.AC_000180.1.345 P01030 CO4_BOVIN 98.826 0.418593 2.20978 C4 - Complement C4 precursor - Bos taurus (Bovine) - C4 gene Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity). Taurus_UMD|evm.model.AC_000180.1.346 P49842 STK19_HUMAN 87.984 0.992157 0.692935 STK19 - Serine/threonine-protein kinase 19 - Homo sapiens (Human) - STK19 gene Serine/threonine-protein kinase that acts as a key regulator of NRAS signaling by mediating phosphorylation of NRAS at 'Ser-89', thereby enhancing NRAS-binding to its downstream effectors. Taurus_UMD|evm.model.AC_000180.1.347 Q5E9Y5 DXO_BOVIN 99.496 0.994975 1.00252 DXO - Decapping and exoribonuclease protein - Bos taurus (Bovine) - DXO gene Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Preferentially acts on NAD-capped transcripts in response to environmental stress (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation. Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). In contrast to canonical decapping enzymes DCP2 and NUDT16, which cleave the cap within the triphosphate linkage, the decapping activity releases the entire cap structure GpppN and a 5'-end monophosphate RNA. Also has 5'-3' exoribonuclease activities: The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). Taurus_UMD|evm.model.AC_000180.1.348 Q15477 SKIV2_HUMAN 94.703 0.998396 1.0008 SKIV2L - Helicase SKI2W - Homo sapiens (Human) - SKIV2L gene Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). Taurus_UMD|evm.model.AC_000180.1.349 Q0V898 NELFE_BOVIN 100.000 0.994667 1.00267 NELFE - Negative elongation factor E - Bos taurus (Bovine) - NELFE gene Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (By similarity). Taurus_UMD|evm.model.AC_000180.1.350 P81187 CFAB_BOVIN 100.000 0.997375 1.00131 CFB - Complement factor B precursor - Bos taurus (Bovine) - CFB gene Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. Taurus_UMD|evm.model.AC_000180.1.351 Q3SYW2 CO2_BOVIN 99.867 0.997337 1.00133 C2 - Complement C2 precursor - Bos taurus (Bovine) - C2 gene Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity). Taurus_UMD|evm.model.AC_000180.1.352 Q9Y330 ZBT12_HUMAN 98.911 0.995652 1.00218 ZBTB12 - Zinc finger and BTB domain-containing protein 12 - Homo sapiens (Human) - ZBTB12 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000180.1.353 Q96KQ7 EHMT2_HUMAN 97.934 0.997525 1.00165 EHMT2 - Histone-lysine N-methyltransferase EHMT2 - Homo sapiens (Human) - EHMT2 gene Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. Taurus_UMD|evm.model.AC_000180.1.354 A3KMY4 CTL4_BOVIN 92.504 0.99705 0.958982 SLC44A4 - Choline transporter-like protein 4 - Bos taurus (Bovine) - SLC44A4 gene Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (By similarity). Taurus_UMD|evm.model.AC_000180.1.355 A6BMK7 NEUR1_BOVIN 100.000 0.995192 1.00241 NEU1 - Sialidase-1 precursor - Bos taurus (Bovine) - NEU1 gene Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage (By similarity). Taurus_UMD|evm.model.AC_000180.1.356 Q27975 HS71A_BOVIN 100.000 0.996885 1.00156 HSPA1A - Heat shock 70 kDa protein 1A - Bos taurus (Bovine) - HSPA1A gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation. Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle. Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Taurus_UMD|evm.model.AC_000180.1.357 P0CB32 HS71L_BOVIN 100.000 0.996885 1.00156 HSPA1L - Heat shock 70 kDa protein 1-like - Bos taurus (Bovine) - HSPA1L gene Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria. Taurus_UMD|evm.model.AC_000180.1.358 O35900 LSM2_MOUSE 100.000 0.979167 1.01053 Lsm2 - U6 snRNA-associated Sm-like protein LSm2 - Mus musculus (Mouse) - Lsm2 gene Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Taurus_UMD|evm.model.AC_000180.1.359 P26640 SYVC_HUMAN 94.570 0.894309 0.19462 VARS1 - Valine--tRNA ligase - Homo sapiens (Human) - VARS1 gene cytosol, valine-tRNA ligase activity, tRNA aminoacylation for protein translation, valyl-tRNA aminoacylation Taurus_UMD|evm.model.AC_000180.1.360 Q0V8J4 VWA7_BOVIN 96.429 0.965479 1.00786 VWA7 - von Willebrand factor A domain-containing protein 7 precursor - Bos taurus (Bovine) - VWA7 gene Taurus_UMD|evm.model.AC_000180.1.361 P26640 SYVC_HUMAN 95.253 0.997938 0.767405 VARS1 - Valine--tRNA ligase - Homo sapiens (Human) - VARS1 gene cytosol, valine-tRNA ligase activity, tRNA aminoacylation for protein translation, valyl-tRNA aminoacylation Taurus_UMD|evm.model.AC_000180.1.362 O43196 MSH5_HUMAN 92.566 0.997596 0.997602 MSH5 - MutS protein homolog 5 - Homo sapiens (Human) - MSH5 gene Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity). Taurus_UMD|evm.model.AC_000180.1.363 Q5E9B7 CLIC1_BOVIN 100.000 0.991736 1.00415 CLIC1 - Chloride intracellular channel protein 1 - Bos taurus (Bovine) - CLIC1 gene Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity). Taurus_UMD|evm.model.AC_000180.1.364 Q3SX44 DDAH2_BOVIN 100.000 0.993007 1.00351 DDAH2 - N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 - Bos taurus (Bovine) - DDAH2 gene Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation (By similarity). Taurus_UMD|evm.model.AC_000180.1.365 O95866 G6B_HUMAN 77.293 0.937238 0.991701 MPIG6B - Megakaryocyte and platelet inhibitory receptor G6b precursor - Homo sapiens (Human) - MPIG6B gene Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed:12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:17311996). Appears to operate in a calcium-independent manner (PubMed:12665801). Taurus_UMD|evm.model.AC_000180.1.366 A0JNL5 LY66C_BOVIN 100.000 0.953846 1.04 LY6G6C - Lymphocyte antigen 6 complex locus protein G6c precursor - Bos taurus (Bovine) - LY6G6C gene protein-containing complex Taurus_UMD|evm.model.AC_000180.1.367 O95868 LY66D_HUMAN 65.248 0.984848 0.992481 LY6G6D - Lymphocyte antigen 6 complex locus protein G6d precursor - Homo sapiens (Human) - LY6G6D gene extracellular region, plasma membrane, protein-containing complex, acetylcholine receptor inhibitor activity, identical protein binding, acetylcholine receptor signaling pathway Taurus_UMD|evm.model.AC_000180.1.368 Q8K1T6 LY66E_MOUSE 51.515 0.81761 0.957831 Ly6g6e - Lymphocyte antigen 6G6e precursor - Mus musculus (Mouse) - Ly6g6e gene Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro potentiates alpha-3:beta-4-containing nAChRs maximum response by increasing peak current and slowing down receptor desensitization; the activity is dependent on its cell surface localization. Taurus_UMD|evm.model.AC_000180.1.369 Q0V881 LY66F_BOVIN 98.625 0.989761 0.979933 LY6G6F - Lymphocyte antigen 6 complex locus protein G6f precursor - Bos taurus (Bovine) - LY6G6F gene May play a role in the downstream signal transduction pathways involving GRB2 and GRB7. Taurus_UMD|evm.model.AC_000180.1.370 Q1JPD2 ABHGA_BOVIN 99.821 0.996422 1.00179 ABHD16A - Phosphatidylserine lipase ABHD16A - Bos taurus (Bovine) - ABHD16A gene Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (By similarity). Taurus_UMD|evm.model.AC_000180.1.371 Q8NDX9 LY65B_HUMAN 73.333 0.979798 0.985075 LY6G5B - Lymphocyte antigen 6 complex locus protein G5b precursor - Homo sapiens (Human) - LY6G5B gene protein-containing complex, identical protein binding Taurus_UMD|evm.model.AC_000180.1.372 P67874 CSK2B_RAT 100.000 0.90678 1.09767 Csnk2b - Casein kinase II subunit beta - Rattus norvegicus (Rat) - Csnk2b gene Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:16818610). Participates in Wnt signaling (By similarity). Taurus_UMD|evm.model.AC_000180.1.373 O95872 GPAN1_HUMAN 82.303 0.994318 0.988764 GPANK1 - G patch domain and ankyrin repeat-containing protein 1 - Homo sapiens (Human) - GPANK1 gene Taurus_UMD|evm.model.AC_000180.1.374 O95873 CF047_HUMAN 80.201 0.993289 1.01361 C6orf47 - Uncharacterized protein C6orf47 - Homo sapiens (Human) - C6orf47 gene Taurus_UMD|evm.model.AC_000180.1.375 Q2LE37 APOM_PIG 94.681 0.989418 1.00532 APOM - Apolipoprotein M - Sus scrofa (Pig) - APOM gene Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid (By similarity). Taurus_UMD|evm.model.AC_000180.1.376 A5D9M6 BAG6_PIG 96.277 0.94152 1.06117 BAG6 - Large proline-rich protein BAG6 - Sus scrofa (Pig) - BAG6 gene ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome. SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response. BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress. By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis. Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Taurus_UMD|evm.model.AC_000180.1.377 Q5TM26 PRC2A_MACMU 91.429 0.999072 0.997685 PRRC2A - Protein PRRC2A - Macaca mulatta (Rhesus macaque) - PRRC2A gene May play a role in the regulation of pre-mRNA splicing. Taurus_UMD|evm.model.AC_000180.1.378 Q9BDK2 AIF1_BOVIN 100.000 0.986486 1.0068 AIF1 - Allograft inflammatory factor 1 - Bos taurus (Bovine) - AIF1 gene May play a role in macrophage activation and function. Taurus_UMD|evm.model.AC_000180.1.379 Q8MJ02 NCTR3_MACMU 81.818 0.635659 1.28358 NCR3 - Natural cytotoxicity triggering receptor 3 precursor - Macaca mulatta (Rhesus macaque) - NCR3 gene Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation. Taurus_UMD|evm.model.AC_000180.1.380 Q9TSV8 TNFC_PIG 92.667 0.603239 1.64667 LTB - Lymphotoxin-beta - Sus scrofa (Pig) - LTB gene Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Taurus_UMD|evm.model.AC_000180.1.381 Q2MH05 TNFA_BUBCA 100.000 0.991489 1.00427 TNF - Tumor necrosis factor precursor - Bubalus carabanensis (Swamp type water buffalo) - TNF gene Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Taurus_UMD|evm.model.AC_000180.1.382 Q06600 TNFB_BOVIN 100.000 0.990244 1.0049 LTA - Lymphotoxin-alpha precursor - Bos taurus (Bovine) - LTA gene Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. Taurus_UMD|evm.model.AC_000180.1.383 Q9TSV7 IKBL1_PIG 97.375 0.994764 1.00526 NFKBIL1 - NF-kappa-B inhibitor-like protein 1 - Sus scrofa (Pig) - NFKBIL1 gene Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity). Taurus_UMD|evm.model.AC_000180.1.384 Q9TSV6 VATG2_PIG 91.549 0.522727 1.11864 ATP6V1G2 - V-type proton ATPase subunit G 2 - Sus scrofa (Pig) - ATP6V1G2 gene Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Taurus_UMD|evm.model.AC_000180.1.385 Q3T147 DX39B_BOVIN 100.000 0.995338 1.00234 DDX39B - Spliceosome RNA helicase DDX39B - Bos taurus (Bovine) - DDX39B gene Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. Taurus_UMD|evm.model.AC_000180.1.386 P59942 MCCD1_HUMAN 67.257 0.692308 1.31092 MCCD1 - Mitochondrial coiled-coil domain protein 1 precursor - Homo sapiens (Human) - MCCD1 gene Taurus_UMD|evm.model.AC_000180.1.387 P01889 HLAB_HUMAN 57.983 0.757353 0.751381 HLA-B - HLA class I histocompatibility antigen, B alpha chain precursor - Homo sapiens (Human) - HLA-B gene Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:25808313, PubMed:29531227, PubMed:9620674, PubMed:23209413). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:7743181, PubMed:18991276). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:29531227, PubMed:9620674, PubMed:24600035). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227). Taurus_UMD|evm.model.AC_000180.1.388 P23004 QCR2_BOVIN 98.234 0.995595 1.00221 UQCRC2 - Cytochrome b-c1 complex subunit 2, mitochondrial precursor - Bos taurus (Bovine) - UQCRC2 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (PubMed:9694818, PubMed:11073949). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Taurus_UMD|evm.model.AC_000180.1.389 C9JQL5 DSA2D_HUMAN 68.182 0.746575 1.09774 Putative dispanin subfamily A member 2d - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000180.1.390 P13753 HA1B_BOVIN 81.232 0.448509 2.02747 BOLA class I histocompatibility antigen, alpha chain BL3-7 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000180.1.391 Q29980 MICB_HUMAN 49.342 0.926984 0.822454 MICB - MHC class I polypeptide-related sequence B precursor - Homo sapiens (Human) - MICB gene Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. Taurus_UMD|evm.model.AC_000180.1.392 O97552 PO5F1_BOVIN 97.122 0.945205 0.405556 POU5F1 - POU domain, class 5, transcription factor 1 - Bos taurus (Bovine) - POU5F1 gene Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Taurus_UMD|evm.model.AC_000180.1.393 Q9TSV5 PO5F1_PIG 89.381 0.985437 0.572222 POU5F1 - POU domain, class 5, transcription factor 1 - Sus scrofa (Pig) - POU5F1 gene Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Taurus_UMD|evm.model.AC_000180.1.394 Q9TSV4 TCF19_PIG 89.306 0.994203 0.99711 TCF19 - Transcription factor 19 - Sus scrofa (Pig) - TCF19 gene Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression. Taurus_UMD|evm.model.AC_000180.1.395 Q9TSV3 CCHCR_PIG 88.290 0.474916 2.1007 CCHCR1 - Coiled-coil alpha-helical rod protein 1 - Sus scrofa (Pig) - CCHCR1 gene May be a regulator of keratinocyte proliferation or differentiation. Taurus_UMD|evm.model.AC_000180.1.396 Q7YR45 PS1C2_PANTR 82.222 0.985294 1 PSORS1C2 - Psoriasis susceptibility 1 candidate gene 2 protein homolog precursor - Pan troglodytes (Chimpanzee) - PSORS1C2 gene Taurus_UMD|evm.model.AC_000180.1.397 O19084 CDSN_PIG 89.778 0.4 2.48889 CDSN - Corneodesmosin - Sus scrofa (Pig) - CDSN gene Important for the epidermal barrier integrity. Taurus_UMD|evm.model.AC_000180.1.398 P13753 HA1B_BOVIN 75.487 0.971989 0.980769 BOLA class I histocompatibility antigen, alpha chain BL3-7 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000180.1.399 P13753 HA1B_BOVIN 78.830 0.99169 0.991758 BOLA class I histocompatibility antigen, alpha chain BL3-7 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000180.1.401 Q28107 FA5_BOVIN 29.904 0.390306 0.354591 F5 - Coagulation factor V precursor - Bos taurus (Bovine) - F5 gene Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. Taurus_UMD|evm.model.AC_000180.1.403 Q3MIW9 MUCL3_HUMAN 40.789 0.995633 0.88588 MUCL3 - Mucin-like protein 3 precursor - Homo sapiens (Human) - MUCL3 gene May modulate NF-kappaB signaling and play a role in cell growth. Taurus_UMD|evm.model.AC_000180.1.405 Q767M3 SYVM_PIG 91.887 0.924084 1.0791 VARS2 - Valine--tRNA ligase, mitochondrial precursor - Sus scrofa (Pig) - VARS2 gene cytosol, valine-tRNA ligase activity, valyl-tRNA aminoacylation Taurus_UMD|evm.model.AC_000180.1.406 P60027 TF2H4_PANTR 98.488 0.99569 1.00433 GTF2H4 - General transcription factor IIH subunit 4 - Pan troglodytes (Chimpanzee) - GTF2H4 gene Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Taurus_UMD|evm.model.AC_000180.1.407 Q08345 DDR1_HUMAN 92.123 0.99776 0.978094 DDR1 - Epithelial discoidin domain-containing receptor 1 precursor - Homo sapiens (Human) - DDR1 gene Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. Taurus_UMD|evm.model.AC_000180.1.409 Q7YR42 IEX1_PANTR 81.410 0.987261 1.00641 IER3 - Radiation-inducible immediate-early gene IEX-1 - Pan troglodytes (Chimpanzee) - IER3 gene May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment (By similarity). Taurus_UMD|evm.model.AC_000180.1.410 Q08DN8 FLOT1_BOVIN 100.000 0.995327 1.00234 FLOT1 - Flotillin-1 - Bos taurus (Bovine) - FLOT1 gene May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. Taurus_UMD|evm.model.AC_000180.1.411 P09244 TBB7_CHICK 100.000 0.995506 1.00225 Tubulin beta-7 chain - Gallus gallus (Chicken) Taurus_UMD|evm.model.AC_000180.1.412 Q32LM8 NRM_BOVIN 100.000 0.992395 1.00382 NRM - Nurim - Bos taurus (Bovine) - NRM gene nuclear envelope, nuclear membrane Taurus_UMD|evm.model.AC_000180.1.413 Q14676 MDC1_HUMAN 65.636 0.469516 0.840115 MDC1 - Mediator of DNA damage checkpoint protein 1 - Homo sapiens (Human) - MDC1 gene Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. Taurus_UMD|evm.model.AC_000180.1.414 Q767M0 PPR18_PIG 84.405 0.996716 0.985437 PPP1R18 - Phostensin - Sus scrofa (Pig) - PPP1R18 gene May target protein phosphatase 1 to F-actin cytoskeleton. Taurus_UMD|evm.model.AC_000180.1.415 Q7YR39 DHX16_PANTR 97.799 0.998088 1.00192 DHX16 - Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 - Pan troglodytes (Chimpanzee) - DHX16 gene Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. Taurus_UMD|evm.model.AC_000180.1.416 Q32KT5 CF136_BOVIN 99.683 0.418667 2.38095 Uncharacterized protein C6orf136 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000180.1.417 P82918 RT18B_BOVIN 99.225 0.992278 1.00388 MRPS18B - 28S ribosomal protein S18b, mitochondrial precursor - Bos taurus (Bovine) - MRPS18B gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000180.1.418 Q767K9 PP1RA_PIG 97.946 0.997838 1 PPP1R10 - Serine/threonine-protein phosphatase 1 regulatory subunit 10 - Sus scrofa (Pig) - PPP1R10 gene Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity). Taurus_UMD|evm.model.AC_000180.1.419 Q8NE71 ABCF1_HUMAN 96.824 0.997639 1.00237 ABCF1 - ATP-binding cassette sub-family F member 1 - Homo sapiens (Human) - ABCF1 gene Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. Taurus_UMD|evm.model.AC_000180.1.420 Q767L1 PRR3_PIG 97.710 0.691489 1.43511 PRR3 - Proline-rich protein 3 - Sus scrofa (Pig) - PRR3 gene Taurus_UMD|evm.model.AC_000180.1.421 Q5RA07 GNL1_PONAB 98.750 0.928295 0.850082 GNL1 - Guanine nucleotide-binding protein-like 1 - Pongo abelii (Sumatran orangutan) - GNL1 gene Possible regulatory or functional link with the histocompatibility cluster. Taurus_UMD|evm.model.AC_000180.1.422 Q5TM57 RPP21_MACMU 90.789 0.974194 1.00649 RPP21 - Ribonuclease P protein subunit p21 - Macaca mulatta (Rhesus macaque) - RPP21 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Taurus_UMD|evm.model.AC_000180.1.423 Q9ESN2 TRI39_MOUSE 97.541 0.99591 1.00205 Trim39 - E3 ubiquitin-protein ligase TRIM39 - Mus musculus (Mouse) - Trim39 gene E3 ubiquitin-protein ligase (By similarity). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similarity). Taurus_UMD|evm.model.AC_000180.1.424 Q5RA31 TOM20_PONAB 98.990 0.803279 0.841379 TOMM20 - Mitochondrial import receptor subunit TOM20 homolog - Pongo abelii (Sumatran orangutan) - TOMM20 gene Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. Taurus_UMD|evm.model.AC_000180.1.425 P13753 HA1B_BOVIN 55.394 0.946328 0.972527 BOLA class I histocompatibility antigen, alpha chain BL3-7 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000180.1.426 D4A615 TONSL_RAT 64.103 0.308943 0.0899781 Tonsl - Tonsoku-like protein - Rattus norvegicus (Rat) - Tonsl gene Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold (By similarity). Taurus_UMD|evm.model.AC_000180.1.427 P13753 HA1B_BOVIN 91.111 0.860911 1.1456 BOLA class I histocompatibility antigen, alpha chain BL3-7 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000180.1.428 Q12899 TRI26_HUMAN 56.287 0.193699 1.58998 TRIM26 - Tripartite motif-containing protein 26 - Homo sapiens (Human) - TRIM26 gene E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Taurus_UMD|evm.model.AC_000180.1.429 Q12899 TRI26_HUMAN 94.249 0.996296 1.00186 TRIM26 - Tripartite motif-containing protein 26 - Homo sapiens (Human) - TRIM26 gene E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Taurus_UMD|evm.model.AC_000180.1.430 Q9TSW0 TRI15_PIG 90.456 0.995671 1.00217 TRIM15 - Tripartite motif-containing protein 15 - Sus scrofa (Pig) - TRIM15 gene cytoplasm, ubiquitin protein ligase activity, innate immune response, positive regulation of NF-kappaB transcription factor activity, protein ubiquitination, regulation of gene expression Taurus_UMD|evm.model.AC_000180.1.431 Q5E9G4 TRI10_BOVIN 99.796 0.995918 1.00204 TRIM10 - Tripartite motif-containing protein 10 - Bos taurus (Bovine) - TRIM10 gene Seems to play an important role in erythropoiesis. Taurus_UMD|evm.model.AC_000180.1.432 Q6P9F5 TRI40_HUMAN 61.417 0.807309 1.16667 TRIM40 - E3 ubiquitin ligase TRIM40 - Homo sapiens (Human) - TRIM40 gene E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response (PubMed:21474709, PubMed:29117565). Mediates inhibition of the RLR signaling pathway by ubiquitinating DDX58 and IFIH1 receptors, leading to their proteasomal degradation (PubMed:21474709). Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation (PubMed:21474709). Taurus_UMD|evm.model.AC_000180.1.433 Q9BZY9 TRI31_HUMAN 62.462 0.590747 1.32235 TRIM31 - E3 ubiquitin-protein ligase TRIM31 - Homo sapiens (Human) - TRIM31 gene Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity. Taurus_UMD|evm.model.AC_000180.1.434 Q7YR31 RNF39_PANTR 84.659 0.99115 0.807143 RNF39 - RING finger protein 39 - Pan troglodytes (Chimpanzee) - RNF39 gene May play a role in prolonged long term-potentiation (LTP) maintenance. Taurus_UMD|evm.model.AC_000180.1.435 Q7YR30 PP1RB_PANTR 96.032 0.984252 1.00794 PPP1R11 - E3 ubiquitin-protein ligase PPP1R11 - Pan troglodytes (Chimpanzee) - PPP1R11 gene Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1. Taurus_UMD|evm.model.AC_000180.1.436 Q1RMP0 RPA12_BOVIN 100.000 0.983871 1.00813 POLR1H - DNA-directed RNA polymerase I subunit RPA12 - Bos taurus (Bovine) - POLR1H gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Taurus_UMD|evm.model.AC_000180.1.437 Q8R0E5 ZRAS1_MOUSE 59.116 0.497238 1.69953 Znrd1-as - Putative uncharacterized protein ZNRD1-AS1 - Mus musculus (Mouse) - Znrd1-as gene May be involved in male sterility. Taurus_UMD|evm.model.AC_000180.1.438 Q9NU63 ZFP57_HUMAN 48.473 0.924354 1.19912 ZFP57 - Zinc finger protein 57 homolog - Homo sapiens (Human) - ZFP57 gene Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:18622393, PubMed:30602440). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). Taurus_UMD|evm.model.AC_000180.1.439 P55803 MOG_BOVIN 100.000 0.991903 1.00407 MOG - Myelin-oligodendrocyte glycoprotein precursor - Bos taurus (Bovine) - MOG gene Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Taurus_UMD|evm.model.AC_000180.1.440 Q9UBS5 GABR1_HUMAN 99.584 0.997921 1.00104 GABBR1 - Gamma-aminobutyric acid type B receptor subunit 1 precursor - Homo sapiens (Human) - GABBR1 gene Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10906333, PubMed:10773016, PubMed:10075644, PubMed:9872744, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9844003, PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen (PubMed:9844003, PubMed:9872316, PubMed:24305054). Taurus_UMD|evm.model.AC_000180.1.441 Q8NGU4 OR2I1_HUMAN 63.441 0.75 0.35443 OR2I1P - Putative olfactory receptor 2I1 - Homo sapiens (Human) - OR2I1P gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.442 Q08DM5 CS012_BOVIN 62.687 0.596413 1.58156 Protein C19orf12 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000180.1.443 Q921A3 UBD_RAT 71.795 0.567766 1.69565 Ubd - Ubiquitin D - Rattus norvegicus (Rat) - Ubd gene Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases (By similarity). Taurus_UMD|evm.model.AC_000180.1.444 Q8NGU4 OR2I1_HUMAN 67.227 0.405498 0.920886 OR2I1P - Putative olfactory receptor 2I1 - Homo sapiens (Human) - OR2I1P gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.445 Q921A3 UBD_RAT 70.000 0.97546 1.01242 Ubd - Ubiquitin D - Rattus norvegicus (Rat) - Ubd gene Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases (By similarity). Taurus_UMD|evm.model.AC_000180.1.446 O95918 OR2H2_HUMAN 82.051 0.987179 0.25 OR2H2 - Olfactory receptor 2H2 - Homo sapiens (Human) - OR2H2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.447 Q9GZK4 OR2H1_HUMAN 85.965 0.896825 0.398734 OR2H1 - Olfactory receptor 2H1 - Homo sapiens (Human) - OR2H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.448 Q921A3 UBD_RAT 72.840 0.98773 1.01242 Ubd - Ubiquitin D - Rattus norvegicus (Rat) - Ubd gene Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases (By similarity). Taurus_UMD|evm.model.AC_000180.1.449 Q8NGU4 OR2I1_HUMAN 84.244 0.91716 1.06962 OR2I1P - Putative olfactory receptor 2I1 - Homo sapiens (Human) - OR2I1P gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.450 Q9GZK7 O11A1_HUMAN 76.433 0.939759 0.526984 OR11A1 - Olfactory receptor 11A1 - Homo sapiens (Human) - OR11A1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.451 Q9GZK7 O11A1_HUMAN 80.124 0.963855 0.526984 OR11A1 - Olfactory receptor 11A1 - Homo sapiens (Human) - OR11A1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.452 Q00715 H2B1_RAT 73.469 0.429907 0.856 Histone H2B type 1 - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000180.1.453 P0DN82 O12D1_HUMAN 81.641 0.962264 0.857605 OR12D1 - Olfactory receptor 12D1 - Homo sapiens (Human) - OR12D1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.454 P58182 O12D2_HUMAN 81.699 0.987055 1.00651 OR12D2 - Olfactory receptor 12D2 - Homo sapiens (Human) - OR12D2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.455 Q9UGF7 O12D3_HUMAN 81.013 0.993691 1.00316 OR12D3 - Olfactory receptor 12D3 - Homo sapiens (Human) - OR12D3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.456 Q9UGF5 O14J1_HUMAN 73.054 0.706383 0.732087 OR14J1 - Olfactory receptor 14J1 - Homo sapiens (Human) - OR14J1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.457 Q9UGF5 O14J1_HUMAN 87.850 0.993789 1.00312 OR14J1 - Olfactory receptor 14J1 - Homo sapiens (Human) - OR14J1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.458 Q8NGZ4 OR2G3_HUMAN 63.399 0.962145 1.02589 OR2G3 - Olfactory receptor 2G3 - Homo sapiens (Human) - OR2G3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.460 A6QLZ5 F177A_BOVIN 98.113 0.990566 1 FAM177A1 - Protein FAM177A1 - Bos taurus (Bovine) - FAM177A1 gene Taurus_UMD|evm.model.AC_000180.1.461 O95918 OR2H2_HUMAN 60.426 0.873134 0.858974 OR2H2 - Olfactory receptor 2H2 - Homo sapiens (Human) - OR2H2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.462 Q5RFL9 NONO_PONAB 97.727 0.977528 0.18896 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Taurus_UMD|evm.model.AC_000180.1.463 Q5FVM4 NONO_RAT 98.049 0.990291 0.432773 Nono - Non-POU domain-containing octamer-binding protein - Rattus norvegicus (Rat) - Nono gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Taurus_UMD|evm.model.AC_000180.1.464 Q8WXF1 PSPC1_HUMAN 72.500 0.333333 0.223709 PSPC1 - Paraspeckle component 1 - Homo sapiens (Human) - PSPC1 gene Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Taurus_UMD|evm.model.AC_000180.1.465 Q9Y3N9 OR2W1_HUMAN 86.782 0.988571 0.546875 OR2W1 - Olfactory receptor 2W1 - Homo sapiens (Human) - OR2W1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.466 Q9Y3N9 OR2W1_HUMAN 87.006 0.988764 0.55625 OR2W1 - Olfactory receptor 2W1 - Homo sapiens (Human) - OR2W1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.470 Q5JNZ3 ZN311_HUMAN 76.733 0.99537 0.972973 ZNF311 - Zinc finger protein 311 - Homo sapiens (Human) - ZNF311 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000180.1.471 P14373 TRI27_HUMAN 99.415 0.996109 1.00195 TRIM27 - Zinc finger protein RFP - Homo sapiens (Human) - TRIM27 gene E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. Taurus_UMD|evm.model.AC_000180.1.472 P68105 EF1A1_RABIT 97.701 0.917548 1.02381 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000180.1.473 A1YEP8 ZSC12_GORGO 84.590 0.745074 1.34437 ZSCAN12 - Zinc finger and SCAN domain-containing protein 12 - Gorilla gorilla gorilla (Western lowland gorilla) - ZSCAN12 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000180.1.474 Q96LW9 ZSC31_HUMAN 79.310 0.84728 1.17734 ZSCAN31 - Zinc finger and SCAN domain-containing protein 31 - Homo sapiens (Human) - ZSCAN31 gene May function as a transcription factor. May be involved in the development of multiple embryonic organs. Taurus_UMD|evm.model.AC_000180.1.475 Q96JS3 PGBD1_HUMAN 75.887 0.997522 0.997528 PGBD1 - PiggyBac transposable element-derived protein 1 - Homo sapiens (Human) - PGBD1 gene DNA-binding transcription factor activity, RNA polymerase II-specific, identical protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000180.1.476 A6QNZ0 ZSC26_BOVIN 99.791 0.995833 1.00209 ZSCAN26 - Zinc finger and SCAN domain-containing protein 26 - Bos taurus (Bovine) - ZSCAN26 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000180.1.477 Q8N5F7 NKAP_HUMAN 86.713 0.355 0.963855 NKAP - NF-kappa-B-activating protein - Homo sapiens (Human) - NKAP gene Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868). Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814). Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. Taurus_UMD|evm.model.AC_000180.1.479 Q969J2 ZKSC4_HUMAN 81.651 0.994485 0.998165 ZKSCAN4 - Zinc finger protein with KRAB and SCAN domains 4 - Homo sapiens (Human) - ZKSCAN4 gene May be involved in the transcriptional activation of MDM2 and EP300 genes. Taurus_UMD|evm.model.AC_000180.1.480 O15535 ZSC9_HUMAN 72.589 0.99435 0.898477 ZSCAN9 - Zinc finger and SCAN domain-containing protein 9 - Homo sapiens (Human) - ZSCAN9 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000180.1.481 Q15007 FL2D_HUMAN 95.926 0.817629 0.830808 WTAP - Pre-mRNA-splicing regulator WTAP - Homo sapiens (Human) - WTAP gene Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724). Taurus_UMD|evm.model.AC_000180.1.482 A2T7F4 ZSC12_PONPY 58.065 0.15405 1.24669 ZSCAN12 - Zinc finger and SCAN domain-containing protein 12 - Pongo pygmaeus (Bornean orangutan) - ZSCAN12 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000180.1.483 A2T736 ZKSC8_PANTR 92.907 0.996546 1.00173 ZKSCAN8 - Zinc finger protein with KRAB and SCAN domains 8 - Pan troglodytes (Chimpanzee) - ZKSCAN8 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000180.1.484 Q9H4T2 ZSC16_HUMAN 85.057 0.994269 1.00287 ZSCAN16 - Zinc finger and SCAN domain-containing protein 16 - Homo sapiens (Human) - ZSCAN16 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000180.1.485 P08043 ZFP2_MOUSE 60.821 0.75 0.775599 Zfp2 - Zinc finger protein 2 - Mus musculus (Mouse) - Zfp2 gene Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance. Taurus_UMD|evm.model.AC_000180.1.486 P49910 ZN165_HUMAN 80.412 0.995885 1.00206 ZNF165 - Zinc finger protein 165 - Homo sapiens (Human) - ZNF165 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000180.1.487 P13752 HA1A_BOVIN 49.550 0.950617 0.225 BOLA class I histocompatibility antigen, alpha chain BL3-6 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000180.1.488 P13752 HA1A_BOVIN 64.662 0.709677 0.516667 BOLA class I histocompatibility antigen, alpha chain BL3-6 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000180.1.489 Q8NHA6 OR2W6_HUMAN 73.154 0.973684 0.477987 OR2W6P - Putative olfactory receptor 2W6 - Homo sapiens (Human) - OR2W6P gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.490 O00370 LORF2_HUMAN 25.000 0.925926 0.127059 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000180.1.491 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000180.1.492 P0C0S8 H2A1_HUMAN 100.000 0.984733 1.00769 H2AC11 - Histone H2A type 1 - Homo sapiens (Human) - H2AC11 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.493 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000180.1.494 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000180.1.495 Q99877 H2B1N_HUMAN 100.000 0.984252 1.00794 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.496 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000180.1.497 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000180.1.498 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000180.1.499 Q99878 H2A1J_HUMAN 100.000 0.984496 1.00781 H2AC14 - Histone H2A type 1-J - Homo sapiens (Human) - H2AC14 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.500 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000180.1.501 P62630 EF1A1_RAT 100.000 0.526738 0.809524 Eef1a1 - Elongation factor 1-alpha 1 - Rattus norvegicus (Rat) - Eef1a1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000180.1.505 A6QLU5 ZN184_BOVIN 100.000 0.997344 1.00133 ZNF184 - Zinc finger protein 184 - Bos taurus (Bovine) - ZNF184 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000180.1.506 Q96KW2 P12L2_HUMAN 63.916 0.99806 0.996135 POM121L2 - POM121-like protein 2 - Homo sapiens (Human) - POM121L2 gene nuclear pore, nuclear localization sequence binding, structural constituent of nuclear pore, protein import into nucleus, RNA export from nucleus Taurus_UMD|evm.model.AC_000180.1.507 Q9NQE7 TSSP_HUMAN 81.409 0.982592 1.00584 PRSS16 - Thymus-specific serine protease precursor - Homo sapiens (Human) - PRSS16 gene Protease that may play a role in T-cell development. Taurus_UMD|evm.model.AC_000180.1.508 Q96KK5 H2A1H_HUMAN 100.000 0.984496 1.00781 H2AC12 - Histone H2A type 1-H - Homo sapiens (Human) - H2AC12 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.509 O60814 H2B1K_HUMAN 100.000 0.984252 1.00794 H2BC12 - Histone H2B type 1-K - Homo sapiens (Human) - H2BC12 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.510 P0C0S8 H2A1_HUMAN 100.000 0.565789 1.75385 H2AC11 - Histone H2A type 1 - Homo sapiens (Human) - H2AC11 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.511 P06899 H2B1J_HUMAN 99.206 0.984252 1.00794 H2BC11 - Histone H2B type 1-J - Homo sapiens (Human) - H2BC11 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.513 Q4R7X8 ZN322_MACFA 94.776 0.995037 1.00249 ZNF322 - Zinc finger protein 322 - Macaca fascicularis (Crab-eating macaque) - ZNF322 gene Transcriptional activator. Important for maintenance of pluripotency in embryonic stem cells. Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes. Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly. Promotes inhibition of MAPK signaling during embryonic stem cell differentiation. Taurus_UMD|evm.model.AC_000180.1.514 Q148M8 ABT1_BOVIN 100.000 0.992754 1.00364 ABT1 - Activator of basal transcription 1 - Bos taurus (Bovine) - ABT1 gene Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity). Taurus_UMD|evm.model.AC_000180.1.517 Q2YDK4 HMGN4_BOVIN 100.000 0.978022 1.01111 HMGN4 - High mobility group nucleosome-binding domain-containing protein 4 - Bos taurus (Bovine) - HMGN4 gene nucleus, chromatin binding, chromatin organization Taurus_UMD|evm.model.AC_000180.1.519 P18892 BT1A1_BOVIN 98.917 0.488496 1.07414 BTN1A1 - Butyrophilin subfamily 1 member A1 precursor - Bos taurus (Bovine) - BTN1A1 gene May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane. Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). Taurus_UMD|evm.model.AC_000180.1.520 Q7KYR7 BT2A1_HUMAN 70.530 0.990132 0.57685 BTN2A1 - Butyrophilin subfamily 2 member A1 precursor - Homo sapiens (Human) - BTN2A1 gene external side of plasma membrane, integral component of plasma membrane, plasma membrane, signaling receptor binding, adaptive immune response, lipid metabolic process, regulation of cytokine production, T cell receptor signaling pathway Taurus_UMD|evm.model.AC_000180.1.521 P78410 BT3A2_HUMAN 59.155 0.420896 1.00299 BTN3A2 - Butyrophilin subfamily 3 member A2 precursor - Homo sapiens (Human) - BTN3A2 gene Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells. Taurus_UMD|evm.model.AC_000180.1.522 Q13410 BT1A1_HUMAN 54.622 0.695522 0.636882 BTN1A1 - Butyrophilin subfamily 1 member A1 precursor - Homo sapiens (Human) - BTN1A1 gene May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity). Taurus_UMD|evm.model.AC_000180.1.523 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000180.1.524 Q5QNW6 H2B2F_HUMAN 99.206 0.984252 1.00794 H2BC18 - Histone H2B type 2-F - Homo sapiens (Human) - H2BC18 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.525 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000180.1.526 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000180.1.527 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000180.1.528 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000180.1.529 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000180.1.530 A7MAZ5 H13_BOVIN 100.000 0.990991 1.00452 H1-3 - Histone H1.3 - Bos taurus (Bovine) - H1-3 gene H1 histones bind to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. H1 histones are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). Taurus_UMD|evm.model.AC_000180.1.531 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000180.1.532 C0HKE9 H2A1P_MOUSE 99.225 0.450704 2.18462 Hist1h2ap - Histone H2A type 1-P - Mus musculus (Mouse) - Hist1h2ap gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.533 P0C1H3 H2B1_CHICK 100.000 0.970588 0.539683 H2B-I - Histone H2B 1/2/3/4/6 - Gallus gallus (Chicken) - H2B-I gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.534 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000180.1.535 P0C0S8 H2A1_HUMAN 100.000 0.984733 1.00769 H2AC11 - Histone H2A type 1 - Homo sapiens (Human) - H2AC11 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.536 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000180.1.537 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000180.1.538 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000180.1.539 P10854 H2B1M_MOUSE 100.000 0.984252 1.00794 H2bc14 - Histone H2B type 1-M - Mus musculus (Mouse) - H2bc14 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.540 P10412 H14_HUMAN 98.630 0.990909 1.00457 H1-4 - Histone H1.4 - Homo sapiens (Human) - H1-4 gene Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). Taurus_UMD|evm.model.AC_000180.1.541 P0C169 H2A1C_RAT 100.000 0.984733 1.00769 Histone H2A type 1-C - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000180.1.542 Q5R893 H2B1_PONAB 100.000 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000180.1.543 P06348 H1T_PIG 77.901 0.918367 0.92891 H1-6 - Histone H1t - Sus scrofa (Pig) - H1-6 gene Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration. Taurus_UMD|evm.model.AC_000180.1.544 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000180.1.545 Q9GL42 HFE_DICSU 81.180 0.994398 1.02586 HFE - Hereditary hemochromatosis protein homolog precursor - Dicerorhinus sumatrensis (Sumatran rhinoceros) - HFE gene Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. Taurus_UMD|evm.model.AC_000180.1.546 P02253 H12_BOVIN 100.000 0.990654 1.00469 H1-2 - Histone H1.2 - Bos taurus (Bovine) - H1-2 gene Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). Taurus_UMD|evm.model.AC_000180.1.547 Q6LED0 H31_RAT 100.000 0.762712 1.30147 Histone H3.1 - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000180.1.548 P02262 H2A1_RAT 96.471 0.933333 0.692308 Histone H2A type 1 - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000180.1.549 P33778 H2B1B_HUMAN 99.206 0.984252 1.00794 H2BC3 - Histone H2B type 1-B - Homo sapiens (Human) - H2BC3 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.550 C0HKE9 H2A1P_MOUSE 100.000 0.984733 1.00769 Hist1h2ap - Histone H2A type 1-P - Mus musculus (Mouse) - Hist1h2ap gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.551 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000180.1.552 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000180.1.553 Q6WV90 H4_MYTGA 100.000 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000180.1.554 Q6LED0 H31_RAT 100.000 0.985401 1.00735 Histone H3.1 - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000180.1.555 G3N131 H11_BOVIN 100.000 0.990868 1.00459 H1-1 - Histone H1.1 - Bos taurus (Bovine) - H1-1 gene H1 histones bind to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. H1 histones are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling (By similarity). Taurus_UMD|evm.model.AC_000180.1.557 Q58DK8 TRI38_BOVIN 100.000 0.995662 1.00217 TRIM38 - E3 ubiquitin-protein ligase TRIM38 - Bos taurus (Bovine) - TRIM38 gene E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. Taurus_UMD|evm.model.AC_000180.1.558 Q32LF0 NPT3_BOVIN 100.000 0.995833 1.00209 SLC17A2 - Sodium-dependent phosphate transport protein 3 - Bos taurus (Bovine) - SLC17A2 gene Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (By similarity). Taurus_UMD|evm.model.AC_000180.1.559 O00476 NPT4_HUMAN 72.063 0.635628 1.17619 SLC17A3 - Sodium-dependent phosphate transport protein 4 - Homo sapiens (Human) - SLC17A3 gene voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport. Taurus_UMD|evm.model.AC_000180.1.560 Q28722 NPT1_RABIT 62.661 0.991471 1.0086 SLC17A1 - Sodium-dependent phosphate transport protein 1 - Oryctolagus cuniculus (Rabbit) - SLC17A1 gene Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney. Taurus_UMD|evm.model.AC_000180.1.561 Q9Y2C5 S17A4_HUMAN 70.417 0.702346 1.37223 SLC17A4 - Probable small intestine urate exporter - Homo sapiens (Human) - SLC17A4 gene Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro). Taurus_UMD|evm.model.AC_000180.1.562 P0CC09 H2A2A_RAT 89.231 0.876712 0.561538 H2ac18 - Histone H2A type 2-A - Rattus norvegicus (Rat) - H2ac18 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Taurus_UMD|evm.model.AC_000180.1.563 Q00729 H2B1A_RAT 95.276 0.984375 1.00787 H2bc1 - Histone H2B type 1-A - Rattus norvegicus (Rat) - H2bc1 gene Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.564 Q00729 H2B1A_RAT 94.488 0.684783 1.44882 H2bc1 - Histone H2B type 1-A - Rattus norvegicus (Rat) - H2bc1 gene Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.565 Q96QV6 H2A1A_HUMAN 79.389 0.703297 1.38931 H2AC1 - Histone H2A type 1-A - Homo sapiens (Human) - H2AC1 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000180.1.566 A5PJN0 SEGN_BOVIN 99.638 0.99278 1.00362 SCGN - Secretagogin - Bos taurus (Bovine) - SCGN gene cytosol, dendrite, neuron projection, nucleus, synapse, terminal bouton, calcium ion binding, regulation of cytosolic calcium ion concentration, regulation of long-term synaptic potentiation, regulation of presynaptic cytosolic calcium ion concentration Taurus_UMD|evm.model.AC_000180.1.567 Q5VZK9 CARL1_HUMAN 87.930 0.998594 1.0372 CARMIL1 - F-actin-uncapping protein LRRC16A - Homo sapiens (Human) - CARMIL1 gene Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). Taurus_UMD|evm.model.AC_000180.1.568 A2VDZ9 VAPB_BOVIN 94.231 0.799228 1.06584 VAPB - Vesicle-associated membrane protein-associated protein B - Bos taurus (Bovine) - VAPB gene Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. Taurus_UMD|evm.model.AC_000180.1.569 O19074 CMAH_PIG 95.402 0.750865 1.32874 Cytidine monophosphate-N-acetylneuraminic acid hydroxylase - Sus scrofa (Pig) Taurus_UMD|evm.model.AC_000180.1.570 Q3B7M3 RIPR2_BOVIN 99.902 0.970363 1.02953 RIPOR2 - Rho family-interacting cell polarization regulator 2 - Bos taurus (Bovine) - RIPOR2 gene Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function. Required for normal hearing. Taurus_UMD|evm.model.AC_000180.1.571 H3BNL8 ARMD2_HUMAN 68.261 0.991304 1 ARMH2 - Armadillo-like helical domain-containing protein 2 - Homo sapiens (Human) - ARMH2 gene Taurus_UMD|evm.model.AC_000180.1.572 O75496 GEMI_HUMAN 75.676 0.983957 0.894737 GMNN - Geminin - Homo sapiens (Human) - GMNN gene Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:9635433, PubMed:14993212, PubMed:20129055, PubMed:24064211). It is degraded during the mitotic phase of the cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:9635433, PubMed:14993212, PubMed:24064211). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). Taurus_UMD|evm.model.AC_000180.1.573 Q99LU8 CF062_MOUSE 99.127 0.991304 1.00437 Uncharacterized protein C6orf62 homolog - Mus musculus (Mouse) Taurus_UMD|evm.model.AC_000180.1.574 Q9CQR4 ACO13_MOUSE 79.839 0.518987 1.69286 Acot13 - Acyl-coenzyme A thioesterase 13 - Mus musculus (Mouse) - Acot13 gene Catalyzes the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:19405909). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (PubMed:19405909). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity). May play a role in controlling adaptive thermogenesis (PubMed:24072708). Taurus_UMD|evm.model.AC_000180.1.575 A7YWI9 TYDP2_BOVIN 100.000 0.994521 1.00275 TDP2 - Tyrosyl-DNA phosphodiesterase 2 - Bos taurus (Bovine) - TDP2 gene DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. Acts as a regulator of ribosome biogenesis following stress. Taurus_UMD|evm.model.AC_000180.1.576 Q5VV43 K0319_HUMAN 84.063 0.998126 0.995336 KIAA0319 - Dyslexia-associated protein KIAA0319 precursor - Homo sapiens (Human) - KIAA0319 gene Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. Taurus_UMD|evm.model.AC_000180.1.577 Q3MSM3 SSDH_HYLLA 84.860 0.996205 0.985047 ALDH5A1 - Succinate-semialdehyde dehydrogenase, mitochondrial precursor - Hylobates lar (Common gibbon) - ALDH5A1 gene Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Taurus_UMD|evm.model.AC_000180.1.578 P80109 PHLD_BOVIN 99.046 0.997619 1.00119 GPLD1 - Phosphatidylinositol-glycan-specific phospholipase D precursor - Bos taurus (Bovine) - GPLD1 gene This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. Taurus_UMD|evm.model.AC_000180.1.579 Q4R4M1 MRS2_MACFA 89.706 0.916667 1.08824 MRS2 - Magnesium transporter MRS2 homolog, mitochondrial precursor - Macaca fascicularis (Crab-eating macaque) - MRS2 gene Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. Taurus_UMD|evm.model.AC_000180.1.580 Q9UHG0 DCDC2_HUMAN 84.567 0.989496 1 DCDC2 - Doublecortin domain-containing protein 2 - Homo sapiens (Human) - DCDC2 gene Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). Taurus_UMD|evm.model.AC_000180.1.581 Q8IZ57 NRSN1_HUMAN 92.821 0.989796 1.00513 NRSN1 - Neurensin-1 - Homo sapiens (Human) - NRSN1 gene May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. May play a role in memory consolidation (By similarity). Taurus_UMD|evm.model.AC_000180.1.582 Q5R931 RL10_PONAB 65.909 0.713115 0.570093 RPL10 - 60S ribosomal protein L10 - Pongo abelii (Sumatran orangutan) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000180.1.583 O14807 RASM_HUMAN 80.392 0.943925 0.514423 MRAS - Ras-related protein M-Ras precursor - Homo sapiens (Human) - MRAS gene Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway. Taurus_UMD|evm.model.AC_000180.1.584 O46415 FRIL_BOVIN 100.000 0.988636 1.00571 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000180.1.585 Q9BZI7 REN3B_HUMAN 65.000 0.584158 0.20911 UPF3B - Regulator of nonsense transcripts 3B - Homo sapiens (Human) - UPF3B gene Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. Taurus_UMD|evm.model.AC_000180.1.586 P18917 PLRP4_BOVIN 96.818 0.865613 1.05858 PRP4 - Placental prolactin-related protein 4 precursor - Bos taurus (Bovine) - PRP4 gene Placental prolactin-related proteins may play a specific role during gestation. Taurus_UMD|evm.model.AC_000180.1.587 P12402 PLRP3_BOVIN 68.545 0.84 1.17371 PRP3 - Placental prolactin-related protein 3 precursor - Bos taurus (Bovine) - PRP3 gene Placental prolactin-related proteins may play a specific role during gestation. Taurus_UMD|evm.model.AC_000180.1.588 P12402 PLRP3_BOVIN 68.217 0.977099 0.615023 PRP3 - Placental prolactin-related protein 3 precursor - Bos taurus (Bovine) - PRP3 gene Placental prolactin-related proteins may play a specific role during gestation. Taurus_UMD|evm.model.AC_000180.1.589 P05402 PLRP1_BOVIN 100.000 0.904959 1.01681 PRP1 - Placental prolactin-related protein 1 precursor - Bos taurus (Bovine) - PRP1 gene Placental prolactin-related proteins may play a specific role during gestation. Taurus_UMD|evm.model.AC_000180.1.590 P05402 PLRP1_BOVIN 83.562 0.865079 1.05882 PRP1 - Placental prolactin-related protein 1 precursor - Bos taurus (Bovine) - PRP1 gene Placental prolactin-related proteins may play a specific role during gestation. Taurus_UMD|evm.model.AC_000180.1.591 P19159 CSH2_BOVIN 98.198 0.778169 1.19328 CSH2 - Chorionic somatomammotropin hormone 2 precursor - Bos taurus (Bovine) - CSH2 gene extracellular space, hormone activity, prolactin receptor binding, female pregnancy, mammary gland development, positive regulation of cell population proliferation, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels Taurus_UMD|evm.model.AC_000180.1.592 P19159 CSH2_BOVIN 96.296 0.224719 1.4958 CSH2 - Chorionic somatomammotropin hormone 2 precursor - Bos taurus (Bovine) - CSH2 gene extracellular space, hormone activity, prolactin receptor binding, female pregnancy, mammary gland development, positive regulation of cell population proliferation, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels Taurus_UMD|evm.model.AC_000180.1.593 P19159 CSH2_BOVIN 75.789 0.979167 0.403361 CSH2 - Chorionic somatomammotropin hormone 2 precursor - Bos taurus (Bovine) - CSH2 gene extracellular space, hormone activity, prolactin receptor binding, female pregnancy, mammary gland development, positive regulation of cell population proliferation, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels Taurus_UMD|evm.model.AC_000180.1.594 P12402 PLRP3_BOVIN 69.780 0.84186 1.00939 PRP3 - Placental prolactin-related protein 3 precursor - Bos taurus (Bovine) - PRP3 gene Placental prolactin-related proteins may play a specific role during gestation. Taurus_UMD|evm.model.AC_000180.1.595 P12402 PLRP3_BOVIN 99.531 0.84127 1.1831 PRP3 - Placental prolactin-related protein 3 precursor - Bos taurus (Bovine) - PRP3 gene Placental prolactin-related proteins may play a specific role during gestation. Taurus_UMD|evm.model.AC_000180.1.596 P09611 CSH1_BOVIN 100.000 0.870787 0.754237 CSH1 - Chorionic somatomammotropin hormone 1 precursor - Bos taurus (Bovine) - CSH1 gene extracellular space, hormone activity, prolactin receptor binding, female pregnancy, mammary gland development, positive regulation of cell population proliferation, positive regulation of lactation, positive regulation of receptor signaling pathway via JAK-STAT, response to nutrient levels Taurus_UMD|evm.model.AC_000180.1.597 P01239 PRL_BOVIN 100.000 0.991304 1.00437 PRL - Prolactin precursor - Bos taurus (Bovine) - PRL gene Prolactin acts primarily on the mammary gland by promoting lactation. Taurus_UMD|evm.model.AC_000180.1.598 P51859 HDGF_MOUSE 63.942 0.838983 0.995781 Hdgf - Hepatoma-derived growth factor - Mus musculus (Mouse) - Hdgf gene Acts as a transcriptional repressor (By similarity). Has mitogenic activity for fibroblasts (By similarity). Heparin-binding protein (By similarity). Taurus_UMD|evm.model.AC_000180.1.601 Q06945 SOX4_HUMAN 98.089 0.448276 0.734177 SOX4 - Transcription factor SOX-4 - Homo sapiens (Human) - SOX4 gene Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Taurus_UMD|evm.model.AC_000180.1.603 Q5VV42 CDKAL_HUMAN 90.984 0.99455 0.633851 CDKAL1 - Threonylcarbamoyladenosine tRNA methylthiotransferase - Homo sapiens (Human) - CDKAL1 gene Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. Taurus_UMD|evm.model.AC_000180.1.604 O00716 E2F3_HUMAN 95.918 0.836186 0.87957 E2F3 - Transcription factor E2F3 - Homo sapiens (Human) - E2F3 gene Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). Taurus_UMD|evm.model.AC_000180.1.605 O00716 E2F3_HUMAN 94.656 0.825806 0.333333 E2F3 - Transcription factor E2F3 - Homo sapiens (Human) - E2F3 gene Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). Taurus_UMD|evm.model.AC_000180.1.607 Q6ZNC8 MBOA1_HUMAN 90.349 0.989817 0.991919 MBOAT1 - Lysophospholipid acyltransferase 1 - Homo sapiens (Human) - MBOAT1 gene Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA towards a lysophospholipid producing a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Acts on lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) and lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE), and to a lesser extend lysophosphatidylcholine (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor and 1-oleoyl-LPE as acceptor (PubMed:18772128). May play a role in neurite outgrowth during neuronal differentiation (By similarity). Taurus_UMD|evm.model.AC_000180.1.611 A5PK27 R144B_BOVIN 99.671 0.993443 1.00329 RNF144B - E3 ubiquitin-protein ligase RNF144B - Bos taurus (Bovine) - RNF144B gene E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se (By similarity). Taurus_UMD|evm.model.AC_000180.1.613 P35659 DEK_HUMAN 94.133 0.994681 1.00267 DEK - Protein DEK - Homo sapiens (Human) - DEK gene Involved in chromatin organization. Taurus_UMD|evm.model.AC_000180.1.614 Q8NB78 KDM1B_HUMAN 95.377 0.997564 0.998783 KDM1B - Lysine-specific histone demethylase 1B - Homo sapiens (Human) - KDM1B gene Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Taurus_UMD|evm.model.AC_000180.1.615 Q17QQ2 TPMT_BOVIN 100.000 0.99187 1.00408 TPMT - Thiopurine S-methyltransferase - Bos taurus (Bovine) - TPMT gene thiopurine S-methyltransferase activity Taurus_UMD|evm.model.AC_000180.1.616 Q6VVB1 NHLC1_HUMAN 87.374 0.994937 1 NHLRC1 - E3 ubiquitin-protein ligase NHLRC1 - Homo sapiens (Human) - NHLRC1 gene E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. Taurus_UMD|evm.model.AC_000180.1.617 Q9H1H9 KI13A_HUMAN 97.959 0.6 0.0443213 KIF13A - Kinesin-like protein KIF13A - Homo sapiens (Human) - KIF13A gene Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. Taurus_UMD|evm.model.AC_000180.1.618 Q9H1H9 KI13A_HUMAN 95.139 0.995389 0.961219 KIF13A - Kinesin-like protein KIF13A - Homo sapiens (Human) - KIF13A gene Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. Taurus_UMD|evm.model.AC_000180.1.619 P49790 NU153_HUMAN 85.052 0.941868 1.03797 NUP153 - Nuclear pore complex protein Nup153 - Homo sapiens (Human) - NUP153 gene Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). Taurus_UMD|evm.model.AC_000180.1.620 Q9UBU6 FA8A1_HUMAN 82.033 0.995261 1.02179 FAM8A1 - Protein FAM8A1 - Homo sapiens (Human) - FAM8A1 gene Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD). Taurus_UMD|evm.model.AC_000180.1.621 Q5R5X8 CAP2_PONAB 91.387 0.975359 1.02096 CAP2 - Adenylyl cyclase-associated protein 2 - Pongo abelii (Sumatran orangutan) - CAP2 gene May have a regulatory bifunctional role. Taurus_UMD|evm.model.AC_000180.1.623 Q9BX46 RBM24_HUMAN 99.576 0.991561 1.00424 RBM24 - RNA-binding protein 24 - Homo sapiens (Human) - RBM24 gene Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:20977548, PubMed:24375645, PubMed:29358667, PubMed:29104163). Plays a major role in pre-mRNA alternative splicing regulation (PubMed:26990106, PubMed:29104163). Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (PubMed:29104163). Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes (PubMed:26990106). Plays a role in the regulation of mRNA stability (PubMed:20977548, PubMed:24356969, PubMed:24375645, PubMed:29104163). Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities (PubMed:20977548, PubMed:24356969). Involved in myogenic differentiation by regulating MYOG levels (PubMed:20977548). Binds to multiple regions in the mRNA 3'-UTR of TP63 isoform 2, hence inducing its destabilization (PubMed:24375645). Promotes also the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence (PubMed:29104163). Plays a role in the regulation of mRNA translation (PubMed:29358667). Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation (PubMed:29358667). Binds to a huge amount of mRNAs (PubMed:29104163). Required for embryonic heart development, sarcomer and M-band formation in striated muscles (By similarity). Taurus_UMD|evm.model.AC_000180.1.624 H3BQB6 STMD1_HUMAN 69.203 0.992647 0.985507 STMND1 - Stathmin domain-containing protein 1 - Homo sapiens (Human) - STMND1 gene cytoplasm, neuron projection, tubulin binding, microtubule depolymerization, neuron projection development, regulation of microtubule polymerization or depolymerization Taurus_UMD|evm.model.AC_000180.1.626 Q63540 ATX1_RAT 81.863 0.961039 1.07351 Atxn1 - Ataxin-1 - Rattus norvegicus (Rat) - Atxn1 gene Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved brain development. Taurus_UMD|evm.model.AC_000180.1.627 Q9Z244 GMPR1_RAT 95.930 0.991329 1.0029 Gmpr - GMP reductase 1 - Rattus norvegicus (Rat) - Gmpr gene Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Taurus_UMD|evm.model.AC_000180.1.628 Q8WY64 MYLIP_HUMAN 95.281 0.995516 1.00225 MYLIP - E3 ubiquitin-protein ligase MYLIP - Homo sapiens (Human) - MYLIP gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. Taurus_UMD|evm.model.AC_000180.1.629 Q2HJA5 DTBP1_BOVIN 99.628 0.872964 0.897661 DTNBP1 - Dysbindin - Bos taurus (Bovine) - DTNBP1 gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway (By similarity). Taurus_UMD|evm.model.AC_000180.1.630 Q92833 JARD2_HUMAN 92.817 0.995958 0.992777 JARID2 - Protein Jumonji - Homo sapiens (Human) - JARID2 gene Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity). Taurus_UMD|evm.model.AC_000180.1.631 P19133 FRIL_PIG 56.897 0.53271 1.37179 FTL - Ferritin light chain - Sus scrofa (Pig) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000180.1.633 Q9WVF8 TUSC2_MOUSE 53.521 0.721649 0.881818 Tusc2 - Tumor suppressor candidate 2 - Mus musculus (Mouse) - Tusc2 gene mitochondrion, cell maturation, defense response to Gram-negative bacterium, inflammatory response, natural killer cell differentiation, negative regulation of interleukin-17 production, neutrophil-mediated killing of gram-negative bacterium, phagocytosis, positive regulation of interleukin-10 production, regulation of mitochondrial membrane potential Taurus_UMD|evm.model.AC_000180.1.634 Q01151 CD83_HUMAN 74.146 0.99 0.97561 CD83 - CD83 antigen precursor - Homo sapiens (Human) - CD83 gene May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation. Taurus_UMD|evm.model.AC_000180.1.635 D3ZBM4 RN182_RAT 92.683 0.98 1.01215 Rnf182 - E3 ubiquitin-protein ligase RNF182 - Rattus norvegicus (Rat) - Rnf182 gene E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. Taurus_UMD|evm.model.AC_000180.1.636 Q9CXD6 MCUR1_MOUSE 80.995 0.833333 0.776471 Mcur1 - Mitochondrial calcium uniporter regulator 1 - Mus musculus (Mouse) - Mcur1 gene Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU. Probably involved in the assembly of the membrane components of the uniporter complex (uniplex). Taurus_UMD|evm.model.AC_000180.1.637 Q96S59 RANB9_HUMAN 96.481 0.889256 0.829904 RANBP9 - Ran-binding protein 9 - Homo sapiens (Human) - RANBP9 gene May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. Taurus_UMD|evm.model.AC_000180.1.638 Q9UMY1 NOL7_HUMAN 87.938 0.988372 1.00389 NOL7 - Nucleolar protein 7 - Homo sapiens (Human) - NOL7 gene chromosome, mitochondrion, nucleolus, RNA binding Taurus_UMD|evm.model.AC_000180.1.639 Q3ZBQ0 SIR5_BOVIN 100.000 0.993569 1.00323 SIRT5 - NAD-dependent protein deacylase sirtuin-5, mitochondrial precursor - Bos taurus (Bovine) - SIRT5 gene NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. Taurus_UMD|evm.model.AC_000180.1.640 Q3UHD2 GFOD1_MOUSE 97.701 0.688 0.320513 Gfod1 - Glucose-fructose oxidoreductase domain-containing protein 1 precursor - Mus musculus (Mouse) - Gfod1 gene Taurus_UMD|evm.model.AC_000180.1.641 Q9NXC2 GFOD1_HUMAN 99.552 0.991071 0.574359 GFOD1 - Glucose-fructose oxidoreductase domain-containing protein 1 precursor - Homo sapiens (Human) - GFOD1 gene Taurus_UMD|evm.model.AC_000180.1.642 Q5E9C4 TBCD7_BOVIN 100.000 0.993197 1.00341 TBC1D7 - TBC1 domain family member 7 - Bos taurus (Bovine) - TBC1D7 gene Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question (By similarity). Taurus_UMD|evm.model.AC_000180.1.645 P17322 EDN1_BOVIN 99.454 0.95288 0.945545 EDN1 - Endothelin-1 precursor - Bos taurus (Bovine) - EDN1 gene Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Taurus_UMD|evm.model.AC_000180.1.646 Q1JQB5 FBLI1_BOVIN 100.000 0.216561 0.415344 FBLIM1 - Filamin-binding LIM protein 1 - Bos taurus (Bovine) - FBLIM1 gene Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). Taurus_UMD|evm.model.AC_000180.1.648 P15822 ZEP1_HUMAN 60.177 0.990566 0.0779985 HIVEP1 - Zinc finger protein 40 - Homo sapiens (Human) - HIVEP1 gene This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. Taurus_UMD|evm.model.AC_000180.1.649 Q5T1R4 ZEP3_HUMAN 80.000 0.0281748 1.01787 HIVEP3 - Transcription factor HIVEP3 - Homo sapiens (Human) - HIVEP3 gene Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. Taurus_UMD|evm.model.AC_000180.1.650 Q96IZ2 ADTRP_HUMAN 75.217 0.991342 1.00435 ADTRP - Androgen-dependent TFPI-regulating protein - Homo sapiens (Human) - ADTRP gene Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed:21868574). Taurus_UMD|evm.model.AC_000180.1.651 Q5T4T1 T170B_HUMAN 88.235 0.92126 0.962121 TMEM170B - Transmembrane protein 170B - Homo sapiens (Human) - TMEM170B gene Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets (PubMed:29367600). Taurus_UMD|evm.model.AC_000180.1.652 Q14511 CASL_HUMAN 84.072 0.997585 0.992806 NEDD9 - Enhancer of filamentation 1 - Homo sapiens (Human) - NEDD9 gene Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. Required for correct adhesion and migration of T-cells (PubMed:17174122). Taurus_UMD|evm.model.AC_000180.1.654 P0DJ93 SIM13_HUMAN 94.253 0.977273 0.967033 SMIM13 - Small integral membrane protein 13 - Homo sapiens (Human) - SMIM13 gene Taurus_UMD|evm.model.AC_000180.1.655 Q9NXB9 ELOV2_HUMAN 91.398 0.992806 0.939189 ELOVL2 - Elongation of very long chain fatty acids protein 2 - Homo sapiens (Human) - ELOVL2 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Taurus_UMD|evm.model.AC_000180.1.656 Q5T4T6 SYC2L_HUMAN 62.676 0.882169 1.18103 SYCP2L - Synaptonemal complex protein 2-like - Homo sapiens (Human) - SYCP2L gene Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes. Taurus_UMD|evm.model.AC_000180.1.657 O75603 GCM2_HUMAN 72.781 0.996063 1.00395 GCM2 - Chorion-specific transcription factor GCMb - Homo sapiens (Human) - GCM2 gene Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development. Taurus_UMD|evm.model.AC_000180.1.658 P20794 MAK_HUMAN 83.642 0.996918 1.04173 MAK - Serine/threonine-protein kinase MAK - Homo sapiens (Human) - MAK gene Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. Taurus_UMD|evm.model.AC_000180.1.659 Q3ZCI1 TM14C_BOVIN 100.000 0.470833 2.10526 TMEM14C - Transmembrane protein 14C - Bos taurus (Bovine) - TMEM14C gene Required for normal heme biosynthesis. Taurus_UMD|evm.model.AC_000180.1.660 Q5EA99 PK1IP_BOVIN 99.237 0.994924 1.0051 PAK1IP1 - p21-activated protein kinase-interacting protein 1 - Bos taurus (Bovine) - PAK1IP1 gene Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly. Taurus_UMD|evm.model.AC_000180.1.661 P97402 GCNT2_MOUSE 78.485 0.970414 0.842893 Gcnt2 - N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase - Mus musculus (Mouse) - Gcnt2 gene Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. Taurus_UMD|evm.model.AC_000180.1.662 P97402 GCNT2_MOUSE 80.782 0.944444 0.80798 Gcnt2 - N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase - Mus musculus (Mouse) - Gcnt2 gene Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. Taurus_UMD|evm.model.AC_000180.1.663 Q8N0V5 GNT2A_HUMAN 84.470 0.431148 1.51741 GCNT2 - N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase - Homo sapiens (Human) - GCNT2 gene Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. Taurus_UMD|evm.model.AC_000180.1.664 A1A4R9 AP2A_BOVIN 100.000 0.990909 1.00686 TFAP2A - Transcription factor AP-2-alpha - Bos taurus (Bovine) - TFAP2A gene Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region (By similarity). Taurus_UMD|evm.model.AC_000180.1.668 Q5R831 S35B3_PONAB 91.022 0.925754 1.07481 SLC35B3 - Adenosine 3'-phospho 5'-phosphosulfate transporter 2 - Pongo abelii (Sumatran orangutan) - SLC35B3 gene Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon (By similarity). Taurus_UMD|evm.model.AC_000180.1.670 O43324 MCA3_HUMAN 96.532 0.982857 1.00575 EEF1E1 - Eukaryotic translation elongation factor 1 epsilon-1 - Homo sapiens (Human) - EEF1E1 gene Positive modulator of ATM response to DNA damage. Taurus_UMD|evm.model.AC_000180.1.671 A5A777 BL1S5_PIG 86.911 0.989529 1 BLOC1S5 - Biogenesis of lysosome-related organelles complex 1 subunit 5 - Sus scrofa (Pig) - BLOC1S5 gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking (By similarity). Taurus_UMD|evm.model.AC_000180.1.672 Q8NBS9 TXND5_HUMAN 90.476 0.601449 0.319444 TXNDC5 - Thioredoxin domain-containing protein 5 precursor - Homo sapiens (Human) - TXNDC5 gene Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity). Taurus_UMD|evm.model.AC_000180.1.673 Q8NBS9 TXND5_HUMAN 82.909 0.938356 0.675926 TXNDC5 - Thioredoxin domain-containing protein 5 precursor - Homo sapiens (Human) - TXNDC5 gene Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity). Taurus_UMD|evm.model.AC_000180.1.674 Q04906 BMP6_RAT 84.950 0.993964 0.982213 Bmp6 - Bone morphogenetic protein 6 precursor - Rattus norvegicus (Rat) - Bmp6 gene Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (By similarity). Plays also an important role in the regulation of iron metabolism by acting as a ligand for hemojuvelin/HJV (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (By similarity). Taurus_UMD|evm.model.AC_000180.1.675 Q6B860 RT14_BOVIN 92.188 0.984496 1.00781 MRPS14 - 28S ribosomal protein S14, mitochondrial - Bos taurus (Bovine) - MRPS14 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit, structural constituent of ribosome, mitochondrial translation, translation Taurus_UMD|evm.model.AC_000180.1.676 Q6IEG0 SNR48_HUMAN 86.471 0.994135 1.0059 SNRNP48 - U11/U12 small nuclear ribonucleoprotein 48 kDa protein - Homo sapiens (Human) - SNRNP48 gene Likely involved in U12-type 5' splice site recognition. Taurus_UMD|evm.model.AC_000180.1.677 P15924 DESP_HUMAN 93.977 0.999308 1.00662 DSP - Desmoplakin - Homo sapiens (Human) - DSP gene Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Taurus_UMD|evm.model.AC_000180.1.678 Q9BRS2 RIOK1_HUMAN 88.732 0.996485 1.00176 RIOK1 - Serine/threonine-protein kinase RIO1 - Homo sapiens (Human) - RIOK1 gene Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503). Taurus_UMD|evm.model.AC_000180.1.680 Q95JR0 CAGE1_MACFA 69.380 0.584296 0.515476 CAGE1 - Cancer-associated gene 1 protein homolog - Macaca fascicularis (Crab-eating macaque) - CAGE1 gene Taurus_UMD|evm.model.AC_000180.1.681 A6QLP7 SSRA_BOVIN 100.000 0.969388 1.02797 SSR1 - Translocon-associated protein subunit alpha precursor - Bos taurus (Bovine) - SSR1 gene TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins (By similarity). Taurus_UMD|evm.model.AC_000180.1.682 Q92766 RREB1_HUMAN 72.476 0.883733 1.16242 RREB1 - Ras-responsive element-binding protein 1 - Homo sapiens (Human) - RREB1 gene Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:9305772, PubMed:15067362, PubMed:8816445, PubMed:10390538, PubMed:17550981). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). Taurus_UMD|evm.model.AC_000180.1.686 O95711 LY86_HUMAN 69.136 0.9875 0.987654 LY86 - Lymphocyte antigen 86 precursor - Homo sapiens (Human) - LY86 gene May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity). Taurus_UMD|evm.model.AC_000180.1.688 P12260 F13A_BOVIN 100.000 0.25853 3.84848 F13A1 - Coagulation factor XIII A chain precursor - Bos taurus (Bovine) - F13A1 gene Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Taurus_UMD|evm.model.AC_000180.1.690 A5PK63 RS17_BOVIN 53.571 0.490909 0.814815 RPS17 - 40S ribosomal protein S17 - Bos taurus (Bovine) - RPS17 gene Taurus_UMD|evm.model.AC_000180.1.691 Q2KIC6 NRN1_BOVIN 100.000 0.986014 1.00704 NRN1 - Neuritin precursor - Bos taurus (Bovine) - NRN1 gene Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. Taurus_UMD|evm.model.AC_000180.1.692 Q96KB5 TOPK_HUMAN 78.049 0.859206 0.860248 PBK - Lymphokine-activated killer T-cell-originated protein kinase - Homo sapiens (Human) - PBK gene Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Taurus_UMD|evm.model.AC_000180.1.694 O95363 SYFM_HUMAN 85.144 0.995526 0.991131 FARS2 - Phenylalanine--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - FARS2 gene Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins. Taurus_UMD|evm.model.AC_000180.1.696 O00560 SDCB1_HUMAN 90.659 0.978378 0.620805 SDCBP - Syntenin-1 - Homo sapiens (Human) - SDCBP gene Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). Taurus_UMD|evm.model.AC_000180.1.697 B7ZBB8 PP13G_HUMAN 66.017 0.994203 0.963687 PPP1R3G - Protein phosphatase 1 regulatory subunit 3G - Homo sapiens (Human) - PPP1R3G gene Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity). Taurus_UMD|evm.model.AC_000180.1.698 A7YWU3 RPP40_BOVIN 99.670 0.82967 1.20132 RPP40 - Ribonuclease P protein subunit p40 - Bos taurus (Bovine) - RPP40 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Taurus_UMD|evm.model.AC_000180.1.701 Q9Y232 CDYL_HUMAN 93.669 0.983486 0.911371 CDYL - Chromodomain Y-like protein - Homo sapiens (Human) - CDYL gene Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (PubMed:29177481). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (By similarity). In addition to acting as a chromatin reader, acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity). Taurus_UMD|evm.model.AC_000180.1.704 A6QLH5 ERI3_BOVIN 56.140 0.947368 0.225519 ERI3 - ERI1 exoribonuclease 3 - Bos taurus (Bovine) - ERI3 gene 3'-5'-exoribonuclease activity, DNA catabolic process, exonucleolytic, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000180.1.707 O75521 ECI2_HUMAN 76.880 0.994444 0.913706 ECI2 - Enoyl-CoA delta isomerase 2 precursor - Homo sapiens (Human) - ECI2 gene Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates. Taurus_UMD|evm.model.AC_000180.1.708 Q95JI7 CF201_MACFA 71.707 0.918919 0.956897 QtsA-17053 - Uncharacterized protein C6orf201 homolog - Macaca fascicularis (Crab-eating macaque) - QtsA-17053 gene Taurus_UMD|evm.model.AC_000180.1.709 Q8IXS0 F217A_HUMAN 61.568 0.845649 1.19882 FAM217A - Protein FAM217A - Homo sapiens (Human) - FAM217A gene Taurus_UMD|evm.model.AC_000180.1.710 Q08DZ2 PRP4B_BOVIN 100.000 0.941121 1.06151 PRPF4B - Serine/threonine-protein kinase PRP4 homolog - Bos taurus (Bovine) - PRPF4B gene Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF (By similarity). Taurus_UMD|evm.model.AC_000180.1.712 Q08D85 PXDC1_BOVIN 99.567 0.991379 1.00433 PXDC1 - PX domain-containing protein 1 - Bos taurus (Bovine) - PXDC1 gene Taurus_UMD|evm.model.AC_000180.1.715 A1A5C7 S22AN_HUMAN 91.453 0.953061 0.714286 SLC22A23 - Solute carrier family 22 member 23 - Homo sapiens (Human) - SLC22A23 gene Taurus_UMD|evm.model.AC_000180.1.717 Q5JS54 PSMG4_HUMAN 86.992 0.983871 1.00813 PSMG4 - Proteasome assembly chaperone 4 - Homo sapiens (Human) - PSMG4 gene Chaperone protein which promotes assembly of the 20S proteasome. Taurus_UMD|evm.model.AC_000180.1.718 Q3KRE8 TBB2B_RAT 100.000 0.995516 1.00225 Tubb2b - Tubulin beta-2B chain - Rattus norvegicus (Rat) - Tubb2b gene Tubulin is the major constituent of microtubules (PubMed:19465910). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration (By similarity). Taurus_UMD|evm.model.AC_000180.1.719 P85108 TBB2A_RAT 97.368 0.510204 0.330337 Tubb2a - Tubulin beta-2A chain - Rattus norvegicus (Rat) - Tubb2a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Taurus_UMD|evm.model.AC_000180.1.720 P85108 TBB2A_RAT 100.000 0.995516 1.00225 Tubb2a - Tubulin beta-2A chain - Rattus norvegicus (Rat) - Tubb2a gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Taurus_UMD|evm.model.AC_000180.1.721 Q86WA6 BPHL_HUMAN 87.850 0.560847 0.649485 BPHL - Valacyclovir hydrolase precursor - Homo sapiens (Human) - BPHL gene Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Taurus_UMD|evm.model.AC_000180.1.722 Q13546 RIPK1_HUMAN 74.963 0.996997 0.992548 RIPK1 - Receptor-interacting serine/threonine-protein kinase 1 - Homo sapiens (Human) - RIPK1 gene Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:31827280, PubMed:31827281). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591, PubMed:15310755). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). Taurus_UMD|evm.model.AC_000180.1.723 Q5RBB9 NQO2_PONAB 80.952 0.991379 1.00433 NQO2 - Ribosyldihydronicotinamide dehydrogenase [quinone] - Pongo abelii (Sumatran orangutan) - NQO2 gene The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. Taurus_UMD|evm.model.AC_000180.1.725 O02739 SPB6_BOVIN 88.360 0.718095 1.38889 SERPINB6 - Serpin B6 - Bos taurus (Bovine) - SERPINB6 gene Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress (By similarity). May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Taurus_UMD|evm.model.AC_000180.1.726 O02739 SPB6_BOVIN 84.127 0.994723 1.00265 SERPINB6 - Serpin B6 - Bos taurus (Bovine) - SERPINB6 gene Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress (By similarity). May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Taurus_UMD|evm.model.AC_000180.1.727 O02739 SPB6_BOVIN 80.423 0.994709 1 SERPINB6 - Serpin B6 - Bos taurus (Bovine) - SERPINB6 gene Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress (By similarity). May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Taurus_UMD|evm.model.AC_000180.1.728 O02739 SPB6_BOVIN 100.000 0.32439 1.08466 SERPINB6 - Serpin B6 - Bos taurus (Bovine) - SERPINB6 gene Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress (By similarity). May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Taurus_UMD|evm.model.AC_000180.1.729 P50453 SPB9_HUMAN 67.553 0.994667 0.99734 SERPINB9 - Serpin B9 - Homo sapiens (Human) - SERPINB9 gene Granzyme B inhibitor. Taurus_UMD|evm.model.AC_000180.1.730 Q1JPB0 ILEU_BOVIN 99.187 0.720588 0.901857 SERPINB1 - Leukocyte elastase inhibitor - Bos taurus (Bovine) - SERPINB1 gene Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function. Taurus_UMD|evm.model.AC_000180.1.731 Q1JPB0 ILEU_BOVIN 97.101 0.964789 0.376658 SERPINB1 - Leukocyte elastase inhibitor - Bos taurus (Bovine) - SERPINB1 gene Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function. Taurus_UMD|evm.model.AC_000180.1.732 Q91XU0 WRIP1_MOUSE 89.655 0.995413 0.660606 Wrnip1 - ATPase WRNIP1 - Mus musculus (Mouse) - Wrnip1 gene Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS. Taurus_UMD|evm.model.AC_000180.1.733 Q86YV6 MYLK4_HUMAN 70.909 0.234234 0.572165 MYLK4 - Myosin light chain kinase family member 4 - Homo sapiens (Human) - MYLK4 gene myosin light chain kinase activity Taurus_UMD|evm.model.AC_000180.1.734 Q86YV6 MYLK4_HUMAN 91.275 0.40081 1.90979 MYLK4 - Myosin light chain kinase family member 4 - Homo sapiens (Human) - MYLK4 gene myosin light chain kinase activity Taurus_UMD|evm.model.AC_000180.1.737 O60547 GMDS_HUMAN 97.865 0.886076 0.849462 GMDS - GDP-mannose 4,6 dehydratase - Homo sapiens (Human) - GMDS gene Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. Taurus_UMD|evm.model.AC_000180.1.738 Q61572 FOXC1_MOUSE 98.182 0.268657 0.363472 Foxc1 - Forkhead box protein C1 - Mus musculus (Mouse) - Foxc1 gene DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:9635428, PubMed:9106663, PubMed:10479458, PubMed:10395790, PubMed:11562355, PubMed:18187037, PubMed:19668217, PubMed:22493429, PubMed:24590069, PubMed:25808752, PubMed:28223138). Acts either as a transcriptional activator or repressor (PubMed:28223138). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:25808752). Upon DNA-binding, promotes DNA bending. Acts as a transcriptional coactivator (PubMed:25808752). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (PubMed:25808752). Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (By similarity). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (PubMed:28223138). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (By similarity). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (PubMed:18187037). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (By similarity). Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage (PubMed:9106663, PubMed:10479458, PubMed:10395790, PubMed:10704385, PubMed:11562355, PubMed:15196959). Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC) (PubMed:24590069). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner (PubMed:22171010). May function as a tumor suppressor (By similarity). Taurus_UMD|evm.model.AC_000180.1.741 Q12947 FOXF2_HUMAN 94.428 0.994152 0.77027 FOXF2 - Forkhead box protein F2 - Homo sapiens (Human) - FOXF2 gene Probable transcription activator for a number of lung-specific genes (PubMed:8626802). Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1 (PubMed:29374064). Taurus_UMD|evm.model.AC_000180.1.748 Q96KP1 EXOC2_HUMAN 90.801 0.997838 1.00108 EXOC2 - Exocyst complex component 2 - Homo sapiens (Human) - EXOC2 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Taurus_UMD|evm.model.AC_000180.1.749 Q15306 IRF4_HUMAN 93.792 0.995575 1.00222 IRF4 - Interferon regulatory factor 4 - Homo sapiens (Human) - IRF4 gene Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity). Taurus_UMD|evm.model.AC_000180.1.750 Q9NRW4 DUS22_HUMAN 84.817 0.92233 1.11957 DUSP22 - Dual specificity protein phosphatase 22 - Homo sapiens (Human) - DUSP22 gene Activates the Jnk signaling pathway. Taurus_UMD|evm.model.AC_000180.1.752 Q13136 LIPA1_HUMAN 58.885 0.927869 0.253744 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000180.1.753 Q8NGL7 OR4P4_HUMAN 66.272 0.933333 0.576923 OR4P4 - Olfactory receptor 4P4 - Homo sapiens (Human) - OR4P4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000180.1.754 Q8NGL4 OR5DD_HUMAN 67.925 0.882353 0.378981 OR5D13 - Olfactory receptor 5D13 - Homo sapiens (Human) - OR5D13 gene Odorant receptor. Taurus_UMD|evm.model.AC_000181.1.1 P03374 ENV_MMTVG 42.361 0.959732 0.21657 env - Envelope glycoprotein gp70 precursor - Mouse mammary tumor virus (strain GR) (MMTV) - env gene The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane (By similarity). Taurus_UMD|evm.model.AC_000181.1.3 Q9UPS8 ANR26_HUMAN 50.000 0.92891 0.370175 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000181.1.4 Q13136 LIPA1_HUMAN 80.882 0.462069 0.120632 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000181.1.6 Q8VFK7 O1020_MOUSE 57.927 0.947368 0.539432 Olfr1020 - Olfactory receptor 1020 - Mus musculus (Mouse) - Olfr1020 gene Potential odorant receptor. Taurus_UMD|evm.model.AC_000181.1.7 Q9BYG4 PAR6G_HUMAN 81.915 0.994624 0.989362 PARD6G - Partitioning defective 6 homolog gamma - Homo sapiens (Human) - PARD6G gene Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Taurus_UMD|evm.model.AC_000181.1.8 Q6IQ32 ADNP2_HUMAN 84.696 0.995641 1.01415 ADNP2 - Activity-dependent neuroprotector homeobox protein 2 - Homo sapiens (Human) - ADNP2 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000181.1.9 Q8N0V3 RBFA_HUMAN 65.686 0.993174 0.854227 RBFA - Putative ribosome-binding factor A, mitochondrial precursor - Homo sapiens (Human) - RBFA gene Taurus_UMD|evm.model.AC_000181.1.10 Q9C4M5 GYAR_THELN 45.489 0.790274 0.993958 gyaR - Glyoxylate reductase - Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) - gyaR gene Taurus_UMD|evm.model.AC_000181.1.11 P83877 TXN4A_MOUSE 99.296 0.723077 1.37324 Txnl4a - Thioredoxin-like protein 4A - Mus musculus (Mouse) - Txnl4a gene Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). Taurus_UMD|evm.model.AC_000181.1.12 C9JCN9 HSBPL_HUMAN 56.436 0.561798 2.40541 HSBP1L1 - Heat shock factor-binding protein 1-like protein 1 - Homo sapiens (Human) - HSBP1L1 gene cytosol, nucleus, cellular heat acclimation Taurus_UMD|evm.model.AC_000181.1.13 Q0VCC1 S66A2_BOVIN 73.408 0.992424 1.04348 SLC66A2 - Solute carrier family 66 member 2 - Bos taurus (Bovine) - SLC66A2 gene endosome, trans-Golgi network, phospholipid translocation, retrograde transport, endosome to Golgi Taurus_UMD|evm.model.AC_000181.1.14 Q9UJ96 KCNG2_HUMAN 92.857 0.151099 0.781116 KCNG2 - Potassium voltage-gated channel subfamily G member 2 - Homo sapiens (Human) - KCNG2 gene Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Taurus_UMD|evm.model.AC_000181.1.15 Q7TSG2 CTDP1_MOUSE 66.870 0.997824 0.957292 Ctdp1 - RNA polymerase II subunit A C-terminal domain phosphatase - Mus musculus (Mouse) - Ctdp1 gene Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation (By similarity). Taurus_UMD|evm.model.AC_000181.1.18 P98201 NFAC1_BOVIN 100.000 0.876503 1.13948 NFATC1 - Nuclear factor of activated T-cells, cytoplasmic 1 - Bos taurus (Bovine) - NFATC1 gene Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). Taurus_UMD|evm.model.AC_000181.1.19 A1A4J6 ATP9B_BOVIN 100.000 0.998241 1.00088 ATP9B - Probable phospholipid-transporting ATPase IIB - Bos taurus (Bovine) - ATP9B gene endosome, plasma membrane, trans-Golgi network, ATPase-coupled intramembrane lipid transporter activity, endocytosis, phospholipid translocation, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Taurus_UMD|evm.model.AC_000181.1.20 Q9BXA9 SALL3_HUMAN 82.389 0.699486 1.04692 SALL3 - Sal-like protein 3 - Homo sapiens (Human) - SALL3 gene Probable transcription factor. Taurus_UMD|evm.model.AC_000181.1.26 P17139 CO4A1_CAEEL 32.979 0.756098 0.0699261 emb-9 - Collagen alpha-1(IV) chain precursor - Caenorhabditis elegans - emb-9 gene Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons (PubMed:25080592). May play a role in axon regeneration in embryos following injury in D-type motor neurons (PubMed:27984580). Taurus_UMD|evm.model.AC_000181.1.34 P47211 GALR1_HUMAN 92.837 0.994286 1.00287 GALR1 - Galanin receptor type 1 - Homo sapiens (Human) - GALR1 gene Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Taurus_UMD|evm.model.AC_000181.1.36 P02688 MBP_RAT 82.412 0.484211 1.94872 Mbp - Myelin basic protein - Rattus norvegicus (Rat) - Mbp gene Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). Taurus_UMD|evm.model.AC_000181.1.38 Q9UL36 ZN236_HUMAN 83.768 0.998914 0.998374 ZNF236 - Zinc finger protein 236 - Homo sapiens (Human) - ZNF236 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000181.1.40 Q92618 ZN516_HUMAN 69.918 0.897213 0.987102 ZNF516 - Zinc finger protein 516 - Homo sapiens (Human) - ZNF516 gene Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422). Taurus_UMD|evm.model.AC_000181.1.43 Q6ZSZ6 TSH1_HUMAN 85.674 0.99812 0.987929 TSHZ1 - Teashirt homolog 1 - Homo sapiens (Human) - TSHZ1 gene Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Taurus_UMD|evm.model.AC_000181.1.46 Q24K16 PTGR3_BOVIN 100.000 0.992395 0.697613 ZADH2 - Prostaglandin reductase-3 - Bos taurus (Bovine) - ZADH2 gene Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. Taurus_UMD|evm.model.AC_000181.1.47 Q9C0G0 ZN407_HUMAN 72.510 0.999095 0.983096 ZNF407 - Zinc finger protein 407 - Homo sapiens (Human) - ZNF407 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000181.1.48 Q96KN2 CNDP1_HUMAN 82.268 0.947162 1.00789 CNDP1 - Beta-Ala-His dipeptidase precursor - Homo sapiens (Human) - CNDP1 gene cytosol, dipeptidase activity, peptidase activity, proteolysis, regulation of cellular protein metabolic process Taurus_UMD|evm.model.AC_000181.1.49 Q3ZC84 CNDP2_BOVIN 100.000 0.995798 1.00211 CNDP2 - Cytosolic non-specific dipeptidase - Bos taurus (Bovine) - CNDP2 gene Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis. Taurus_UMD|evm.model.AC_000181.1.50 Q0P6D2 DIK1C_HUMAN 73.869 0.852423 1.08353 DIPK1C - Divergent protein kinase domain 1C - Homo sapiens (Human) - DIPK1C gene Taurus_UMD|evm.model.AC_000181.1.51 Q68DL7 CR063_HUMAN 61.325 0.91453 1.02482 C18orf63 - Uncharacterized protein C18orf63 - Homo sapiens (Human) - C18orf63 gene Taurus_UMD|evm.model.AC_000181.1.52 P00171 CYB5_BOVIN 100.000 0.985185 1.00746 CYB5A - Cytochrome b5 - Bos taurus (Bovine) - CYB5A gene Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. Taurus_UMD|evm.model.AC_000181.1.53 P31621 ENV_JSRV 53.933 0.977901 0.294309 env - Envelope glycoprotein precursor - Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) - env gene The envelope proteins induce cell transformation leading to ovine pulmonary adenocarcinoma (OPA), a contagious lung cancer of sheep and goat. They bind to the HYAL2 receptor for cell entry. Env proteins probably do not act as oncogenes by themselves, but may rather liberate an oncogenic factor that would normally be negatively regulated. One mechanism of transformation seems to involve activation of the phosphoinositide-3-OH kinase (PI3K)/Akt pathway but does not involve the virus receptor HYAL2, and the other seems to involve Env binding to HYAL2, HYAL2 degradation, and activation of the MST1R receptor tyrosine kinase, which is normally suppressed by HYAL2. Taurus_UMD|evm.model.AC_000181.1.54 P31621 ENV_JSRV 40.942 0.967972 0.456911 env - Envelope glycoprotein precursor - Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) - env gene The envelope proteins induce cell transformation leading to ovine pulmonary adenocarcinoma (OPA), a contagious lung cancer of sheep and goat. They bind to the HYAL2 receptor for cell entry. Env proteins probably do not act as oncogenes by themselves, but may rather liberate an oncogenic factor that would normally be negatively regulated. One mechanism of transformation seems to involve activation of the phosphoinositide-3-OH kinase (PI3K)/Akt pathway but does not involve the virus receptor HYAL2, and the other seems to involve Env binding to HYAL2, HYAL2 degradation, and activation of the MST1R receptor tyrosine kinase, which is normally suppressed by HYAL2. Taurus_UMD|evm.model.AC_000181.1.56 P31625 PRO_JSRV 60.550 0.769784 0.160508 pro - Gag-Pro polyprotein - Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) - pro gene Matrix protein. Taurus_UMD|evm.model.AC_000181.1.57 Q3SZV6 TIM21_BOVIN 99.590 0.991837 1.0041 TIMM21 - Mitochondrial import inner membrane translocase subunit Tim21 precursor - Bos taurus (Bovine) - TIMM21 gene Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. Taurus_UMD|evm.model.AC_000181.1.58 Q3SYW0 FBX15_BOVIN 91.202 0.895397 1.02575 FBXO15 - F-box only protein 15 - Bos taurus (Bovine) - FBXO15 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000181.1.61 Q8IUK8 CBLN2_HUMAN 95.982 0.530952 1.875 CBLN2 - Cerebellin-2 precursor - Homo sapiens (Human) - CBLN2 gene Acts as a synaptic organizer in specific subsets of neurons in the brain (By similarity). Essential for long-term maintenance but not establishment of excitatory synapses (By similarity). Taurus_UMD|evm.model.AC_000181.1.62 Q8BUM6 F163B_MOUSE 88.462 0.425 0.718563 Fam163b - Protein FAM163B - Mus musculus (Mouse) - Fam163b gene Taurus_UMD|evm.model.AC_000181.1.65 Q9JLY0 SOCS6_MOUSE 98.469 0.458824 0.797373 Socs6 - Suppressor of cytokine signaling 6 - Mus musculus (Mouse) - Socs6 gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity). Taurus_UMD|evm.model.AC_000181.1.66 Q86VV8 RTTN_HUMAN 83.363 0.999103 1.0018 RTTN - Rotatin - Homo sapiens (Human) - RTTN gene Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2. Taurus_UMD|evm.model.AC_000181.1.67 O18906 CD226_MACMU 51.203 0.992157 0.758929 CD226 - CD226 antigen precursor - Macaca mulatta (Rhesus macaque) - CD226 gene Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding. Taurus_UMD|evm.model.AC_000181.1.68 Q2MHE5 DOK6_MOUSE 98.489 0.993976 1.00302 Dok6 - Docking protein 6 - Mus musculus (Mouse) - Dok6 gene DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance (By similarity). Taurus_UMD|evm.model.AC_000181.1.69 Q68D86 C102B_HUMAN 72.852 0.994106 0.992203 CCDC102B - Coiled-coil domain-containing protein 102B - Homo sapiens (Human) - CCDC102B gene Taurus_UMD|evm.model.AC_000181.1.70 F1LQ48 HNRPL_RAT 86.538 0.239437 0.341894 Hnrnpl - Heterogeneous nuclear ribonucleoprotein L - Rattus norvegicus (Rat) - Hnrnpl gene Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. Taurus_UMD|evm.model.AC_000181.1.71 Q5R875 TMX3_PONAB 88.987 0.995604 1.0022 TMX3 - Protein disulfide-isomerase TMX3 precursor - Pongo abelii (Sumatran orangutan) - TMX3 gene Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase (By similarity). Taurus_UMD|evm.model.AC_000181.1.73 Q8IZU8 DSEL_HUMAN 90.099 0.998351 1.00083 DSEL - Dermatan-sulfate epimerase-like protein precursor - Homo sapiens (Human) - DSEL gene Golgi membrane, chondroitin-glucuronate 5-epimerase activity, chondroitin sulfate metabolic process, dermatan sulfate biosynthetic process, dermatan sulfate metabolic process Taurus_UMD|evm.model.AC_000181.1.75 Q9H159 CAD19_HUMAN 84.845 0.997406 0.998705 CDH19 - Cadherin-19 precursor - Homo sapiens (Human) - CDH19 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Taurus_UMD|evm.model.AC_000181.1.76 Q10126 YSM6_CAEEL 26.250 0.898734 0.566308 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000181.1.77 Q9ULB5 CADH7_HUMAN 98.089 0.997455 1.00127 CDH7 - Cadherin-7 precursor - Homo sapiens (Human) - CDH7 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Taurus_UMD|evm.model.AC_000181.1.79 Q5BIR5 SPB8_BOVIN 100.000 0.994667 1.00267 SERPINB8 - Serpin B8 - Bos taurus (Bovine) - SERPINB8 gene Has an important role in epithelial desmosome-mediated cell-cell adhesion. Taurus_UMD|evm.model.AC_000181.1.80 P05120 PAI2_HUMAN 79.087 0.995204 1.00482 SERPINB2 - Plasminogen activator inhibitor 2 precursor - Homo sapiens (Human) - SERPINB2 gene Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Taurus_UMD|evm.model.AC_000181.1.81 P62246 RS15A_RAT 98.462 0.984733 1.00769 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Taurus_UMD|evm.model.AC_000181.1.82 Q9H2B2 SYT4_HUMAN 92.471 0.995305 1.00235 SYT4 - Synaptotagmin-4 - Homo sapiens (Human) - SYT4 gene Synaptotagmin family member which does not bind Ca(2+) (PubMed:23999003) (By similarity). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Taurus_UMD|evm.model.AC_000181.1.83 Q58DQ3 RL6_BOVIN 99.652 0.993056 1.00348 RPL6 - 60S ribosomal protein L6 - Bos taurus (Bovine) - RPL6 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000181.1.84 Q9H446 RWDD1_HUMAN 66.255 0.91 0.823045 RWDD1 - RWD domain-containing protein 1 - Homo sapiens (Human) - RWDD1 gene Protects DRG2 from proteolytic degradation. Taurus_UMD|evm.model.AC_000181.1.85 Q8NEB9 PK3C3_HUMAN 98.873 0.997748 1.00113 PIK3C3 - Phosphatidylinositol 3-kinase catalytic subunit type 3 - Homo sapiens (Human) - PIK3C3 gene Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity). Taurus_UMD|evm.model.AC_000181.1.86 P23403 RS20_XENLA 100.000 0.976471 0.714286 rps20 - 40S ribosomal protein S20 - Xenopus laevis (African clawed frog) - rps20 gene Taurus_UMD|evm.model.AC_000181.1.89 Q9GMB0 RPN1_PIG 74.194 0.539823 0.185855 RPN1 - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor - Sus scrofa (Pig) - RPN1 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (Probable). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Taurus_UMD|evm.model.AC_000181.1.90 Q9Z222 B3GN2_MOUSE 89.189 0.986577 0.375315 B3GNT2 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 - Mus musculus (Mouse) - B3GNT2 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains (PubMed:9892646). Probably constitutes the main polylactosamine synthase (PubMed:17890318). Taurus_UMD|evm.model.AC_000181.1.93 Q9CPX9 APC11_MOUSE 98.361 0.84507 0.845238 Anapc11 - Anaphase-promoting complex subunit 11 - Mus musculus (Mouse) - Anapc11 gene Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). Taurus_UMD|evm.model.AC_000181.1.95 Q96I25 SPF45_HUMAN 97.506 0.995025 1.00249 RBM17 - Splicing factor 45 - Homo sapiens (Human) - RBM17 gene Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. Taurus_UMD|evm.model.AC_000181.1.98 Q5NVC8 CELF4_PONAB 99.326 0.826493 1.10288 CELF4 - CUGBP Elav-like family member 4 - Pongo abelii (Sumatran orangutan) - CELF4 gene RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). Taurus_UMD|evm.model.AC_000181.1.99 Q86T90 K1328_HUMAN 63.889 0.995381 0.750433 KIAA1328 - Protein hinderin - Homo sapiens (Human) - KIAA1328 gene Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. Taurus_UMD|evm.model.AC_000181.1.100 Q86T90 K1328_HUMAN 83.582 0.647059 0.176776 KIAA1328 - Protein hinderin - Homo sapiens (Human) - KIAA1328 gene Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. Taurus_UMD|evm.model.AC_000181.1.101 Q68CL5 TPGS2_HUMAN 91.513 0.915254 0.983333 TPGS2 - Tubulin polyglutamylase complex subunit 2 - Homo sapiens (Human) - TPGS2 gene Taurus_UMD|evm.model.AC_000181.1.102 Q2V2M9 FHOD3_HUMAN 94.500 0.337563 0.831224 FHOD3 - FH1/FH2 domain-containing protein 3 - Homo sapiens (Human) - FHOD3 gene Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes. Taurus_UMD|evm.model.AC_000181.1.103 Q9N0E7 MOCOS_BOVIN 100.000 0.997735 1.00113 MOCOS - Molybdenum cofactor sulfurase - Bos taurus (Bovine) - MOCOS gene Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. Taurus_UMD|evm.model.AC_000181.1.104 Q6IA86 ELP2_HUMAN 88.996 0.997585 1.00242 ELP2 - Elongator complex protein 2 - Homo sapiens (Human) - ELP2 gene Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:11714725, PubMed:11818576). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Taurus_UMD|evm.model.AC_000181.1.105 Q5R9M9 S39A6_PONAB 92.637 0.997326 1.00673 SLC39A6 - Zinc transporter ZIP6 precursor - Pongo abelii (Sumatran orangutan) - SLC39A6 gene May act as a zinc-influx transporter. Taurus_UMD|evm.model.AC_000181.1.106 Q5R8Y3 RPR1A_PONAB 100.000 0.99361 1.00321 RPRD1A - Regulation of nuclear pre-mRNA domain-containing protein 1A - Pongo abelii (Sumatran orangutan) - RPRD1A gene Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. Taurus_UMD|evm.model.AC_000181.1.107 Q05B49 CR021_BOVIN 99.074 0.990783 1.00463 UPF0711 protein C18orf21 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000181.1.108 Q07537 GALT1_BOVIN 100.000 0.996429 1.00179 GALNT1 - Polypeptide N-acetylgalactosaminyltransferase 1 - Bos taurus (Bovine) - GALNT1 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. Taurus_UMD|evm.model.AC_000181.1.109 Q6PI98 IN80C_HUMAN 94.271 0.989637 1.00521 INO80C - INO80 complex subunit C - Homo sapiens (Human) - INO80C gene Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Taurus_UMD|evm.model.AC_000181.1.110 Q5RAE6 ZNF24_PONAB 97.534 0.879227 1.125 ZNF24 - Zinc finger protein 24 - Pongo abelii (Sumatran orangutan) - ZNF24 gene Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro (By similarity). Taurus_UMD|evm.model.AC_000181.1.111 Q5R5U3 ZN271_PONAB 87.132 0.975647 0.977679 ZNF271 - Zinc finger protein 271 - Pongo abelii (Sumatran orangutan) - ZNF271 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000181.1.112 Q86W11 ZSC30_HUMAN 67.606 0.906452 0.62753 ZSCAN30 - Zinc finger and SCAN domain-containing protein 30 - Homo sapiens (Human) - ZSCAN30 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000181.1.113 Q1LZ87 ZN397_BOVIN 100.000 0.996262 1.00187 ZNF397 - Zinc finger protein 397 - Bos taurus (Bovine) - ZNF397 gene DNA-dependent transcriptional repressor. Taurus_UMD|evm.model.AC_000181.1.114 O15347 HMGB3_HUMAN 83.929 0.837563 0.985 HMGB3 - High mobility group protein B3 - Homo sapiens (Human) - HMGB3 gene Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). Taurus_UMD|evm.model.AC_000181.1.115 Q3SZP2 MARE2_BOVIN 100.000 0.905063 0.969325 MAPRE2 - Microtubule-associated protein RP/EB family member 2 - Bos taurus (Bovine) - MAPRE2 gene May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity). Taurus_UMD|evm.model.AC_000181.1.116 Q9Y4J8 DTNA_HUMAN 88.472 0.996974 0.889637 DTNA - Dystrobrevin alpha - Homo sapiens (Human) - DTNA gene May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. Taurus_UMD|evm.model.AC_000181.1.117 Q58DE2 MSTRO_BOVIN 82.609 0.832117 0.520913 MRO - Protein maestro - Bos taurus (Bovine) - MRO gene Taurus_UMD|evm.model.AC_000181.1.118 O94818 NOL4_HUMAN 97.689 0.997899 0.746082 NOL4 - Nucleolar protein 4 - Homo sapiens (Human) - NOL4 gene nucleolus, RNA binding Taurus_UMD|evm.model.AC_000181.1.119 Q9C0F0 ASXL3_HUMAN 83.147 0.998473 0.87411 ASXL3 - Putative Polycomb group protein ASXL3 - Homo sapiens (Human) - ASXL3 gene Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Taurus_UMD|evm.model.AC_000181.1.120 Q9C0F0 ASXL3_HUMAN 93.878 0.930502 0.115214 ASXL3 - Putative Polycomb group protein ASXL3 - Homo sapiens (Human) - ASXL3 gene Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Taurus_UMD|evm.model.AC_000181.1.121 Q5BJE1 CC178_HUMAN 59.921 0.979381 0.89504 CCDC178 - Coiled-coil domain-containing protein 178 - Homo sapiens (Human) - CCDC178 gene ciliary basal body Taurus_UMD|evm.model.AC_000181.1.122 Q10126 YSM6_CAEEL 25.134 0.79638 0.792115 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000181.1.123 Q69ZK5 KLH14_MOUSE 87.784 0.974719 0.565079 Klhl14 - Kelch-like protein 14 - Mus musculus (Mouse) - Klhl14 gene actin cytoskeleton, aggresome, cytosol, endoplasmic reticulum, neuron projection, neuronal cell body Taurus_UMD|evm.model.AC_000181.1.124 Q69ZK5 KLH14_MOUSE 99.346 0.993485 0.487302 Klhl14 - Kelch-like protein 14 - Mus musculus (Mouse) - Klhl14 gene actin cytoskeleton, aggresome, cytosol, endoplasmic reticulum, neuron projection, neuronal cell body Taurus_UMD|evm.model.AC_000181.1.125 Q9H706 GARE1_HUMAN 90.639 0.997709 0.996575 GAREM1 - GRB2-associated and regulator of MAPK protein 1 - Homo sapiens (Human) - GAREM1 gene Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. Taurus_UMD|evm.model.AC_000181.1.126 Q16820 MEP1B_HUMAN 77.467 0.967143 0.998573 MEP1B - Meprin A subunit beta precursor - Homo sapiens (Human) - MEP1B gene Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. Taurus_UMD|evm.model.AC_000181.1.127 Q32LN5 RN138_BOVIN 100.000 0.757764 1.31429 RNF138 - E3 ubiquitin-protein ligase RNF138 - Bos taurus (Bovine) - RNF138 gene E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. Taurus_UMD|evm.model.AC_000181.1.128 Q95KF1 RN125_MACFA 90.476 0.987124 1.00431 RNF125 - E3 ubiquitin-protein ligase RNF125 - Macaca fascicularis (Crab-eating macaque) - RNF125 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation. Taurus_UMD|evm.model.AC_000181.1.129 Q9Y2L5 TPPC8_HUMAN 92.479 0.998571 0.97561 TRAPPC8 - Trafficking protein particle complex subunit 8 - Homo sapiens (Human) - TRAPPC8 gene Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy (PubMed:26711178). Taurus_UMD|evm.model.AC_000181.1.130 Q9UBX8 B4GT6_HUMAN 98.168 0.994778 1.00262 B4GALT6 - Beta-1,4-galactosyltransferase 6 - Homo sapiens (Human) - B4GALT6 gene Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:3099851, PubMed:1551920, PubMed:24498430). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Taurus_UMD|evm.model.AC_000181.1.131 O46375 TTHY_BOVIN 100.000 0.986486 1.0068 TTR - Transthyretin precursor - Bos taurus (Bovine) - TTR gene Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Taurus_UMD|evm.model.AC_000181.1.132 Q14126 DSG2_HUMAN 76.093 0.929343 1.07603 DSG2 - Desmoglein-2 precursor - Homo sapiens (Human) - DSG2 gene Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Taurus_UMD|evm.model.AC_000181.1.133 Q7YRU7 DSG3_CANLF 79.497 0.997978 0.995972 DSG3 - Desmoglein-3 precursor - Canis lupus familiaris (Dog) - DSG3 gene Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity). Taurus_UMD|evm.model.AC_000181.1.134 Q86SJ6 DSG4_HUMAN 83.285 0.998053 0.9875 DSG4 - Desmoglein-4 precursor - Homo sapiens (Human) - DSG4 gene Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). Taurus_UMD|evm.model.AC_000181.1.135 Q03763 DSG1_BOVIN 97.987 0.998084 1.00096 DSG1 - Desmoglein-1 precursor - Bos taurus (Bovine) - DSG1 gene Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Taurus_UMD|evm.model.AC_000181.1.136 Q01107 DSC1_BOVIN 99.614 0.996154 0.87346 DSC1 - Desmocollin-1 precursor - Bos taurus (Bovine) - DSC1 gene Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. Taurus_UMD|evm.model.AC_000181.1.137 P33545 DSC2_BOVIN 98.957 0.947253 1.05446 DSC2 - Desmocollin-2 precursor - Bos taurus (Bovine) - DSC2 gene Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Taurus_UMD|evm.model.AC_000181.1.138 Q28060 DSC3_BOVIN 98.551 0.997773 1.00223 DSC3 - Desmocollin-3 precursor - Bos taurus (Bovine) - DSC3 gene Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Taurus_UMD|evm.model.AC_000181.1.140 P19534 CADH2_BOVIN 100.000 0.997795 1.0011 CDH2 - Cadherin-2 precursor - Bos taurus (Bovine) - CDH2 gene Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Taurus_UMD|evm.model.AC_000181.1.141 Q8NHP6 MSPD2_HUMAN 84.694 0.524324 0.357143 MOSPD2 - Motile sperm domain-containing protein 2 - Homo sapiens (Human) - MOSPD2 gene Endoplasmic reticulum-anchored receptor which modulates interorganelle contacts by interacting with other organelle-bound proteins via their FFAT motif (PubMed:29858488). Might have a more important role in endoplasmic reticulum and endosomes contacts (PubMed:29858488). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892). Taurus_UMD|evm.model.AC_000181.1.142 A5PJL1 PXMP4_BOVIN 92.925 0.946188 1.05189 PXMP4 - Peroxisomal membrane protein 4 - Bos taurus (Bovine) - PXMP4 gene peroxisomal membrane Taurus_UMD|evm.model.AC_000181.1.143 Q7L1S5 CHST9_HUMAN 85.327 0.995485 1 CHST9 - Carbohydrate sulfotransferase 9 - Homo sapiens (Human) - CHST9 gene Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin. Taurus_UMD|evm.model.AC_000181.1.144 O77750 AQP4_BOVIN 100.000 0.993827 1.0031 AQP4 - Aquaporin-4 - Bos taurus (Bovine) - AQP4 gene Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability. Taurus_UMD|evm.model.AC_000181.1.145 Q2HJ48 KCTD1_BOVIN 100.000 0.296984 3.35409 KCTD1 - BTB/POZ domain-containing protein KCTD1 - Bos taurus (Bovine) - KCTD1 gene May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. Taurus_UMD|evm.model.AC_000181.1.146 Q92750 TAF4B_HUMAN 86.127 0.997688 1.00348 TAF4B - Transcription initiation factor TFIID subunit 4B - Homo sapiens (Human) - TAF4B gene Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. Taurus_UMD|evm.model.AC_000181.1.147 Q4R7D9 PSA7L_MACFA 97.189 0.988048 1.004 PSMA7L - Proteasome subunit alpha type-7-like - Macaca fascicularis (Crab-eating macaque) - PSMA7L gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. Taurus_UMD|evm.model.AC_000181.1.148 Q15532 SSXT_HUMAN 97.129 0.995215 1 SS18 - Protein SSXT - Homo sapiens (Human) - SS18 gene Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Taurus_UMD|evm.model.AC_000181.1.149 Q28205 TBCD_BOVIN 71.154 0.895652 0.0959133 TBCD - Tubulin-specific chaperone D - Bos taurus (Bovine) - TBCD gene Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis. Taurus_UMD|evm.model.AC_000181.1.151 Q96K83 ZN521_HUMAN 97.483 0.998476 1.00076 ZNF521 - Zinc finger protein 521 - Homo sapiens (Human) - ZNF521 gene Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. Taurus_UMD|evm.model.AC_000181.1.154 A7YY45 IMPCT_BOVIN 100.000 0.383117 2.42138 IMPACT - Protein IMPACT - Bos taurus (Bovine) - IMPACT gene Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. Taurus_UMD|evm.model.AC_000181.1.155 Q9BXW6 OSBL1_HUMAN 94.211 0.997897 1.00105 OSBPL1A - Oxysterol-binding protein-related protein 1 - Homo sapiens (Human) - OSBPL1A gene Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). Taurus_UMD|evm.model.AC_000181.1.156 Q710D7 CABYR_VULVU 76.720 0.488251 0.769076 CABYR - Calcium-binding tyrosine phosphorylation-regulated protein - Vulpes vulpes (Red fox) - CABYR gene May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Binds calcium in vitro (By similarity). Taurus_UMD|evm.model.AC_000181.1.157 Q8N584 TT39C_HUMAN 97.256 0.996546 0.993139 TTC39C - Tetratricopeptide repeat protein 39C - Homo sapiens (Human) - TTC39C gene cilium assembly, otolith morphogenesis Taurus_UMD|evm.model.AC_000181.1.158 Q16787 LAMA3_HUMAN 81.736 0.99906 0.957996 LAMA3 - Laminin subunit alpha-3 precursor - Homo sapiens (Human) - LAMA3 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Taurus_UMD|evm.model.AC_000181.1.159 Q8N6D5 ANR29_HUMAN 95.918 0.986532 0.986711 ANKRD29 - Ankyrin repeat domain-containing protein 29 - Homo sapiens (Human) - ANKRD29 gene Taurus_UMD|evm.model.AC_000181.1.160 P56941 NPC1_PIG 91.073 0.998435 1.00078 NPC1 - NPC intracellular cholesterol transporter 1 precursor - Sus scrofa (Pig) - NPC1 gene Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol (By similarity). May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Taurus_UMD|evm.model.AC_000181.1.161 Q96DM3 RMC1_HUMAN 91.020 0.996875 0.974125 RMC1 - Regulator of MON1-CCZ1 complex - Homo sapiens (Human) - RMC1 gene Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162). Taurus_UMD|evm.model.AC_000181.1.162 Q1RMT7 RIOK3_BOVIN 100.000 0.996154 1.00193 RIOK3 - Serine/threonine-protein kinase RIO3 - Bos taurus (Bovine) - RIOK3 gene Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 within the C-terminal region interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA. Taurus_UMD|evm.model.AC_000181.1.163 Q24JQ0 TM241_HUMAN 88.176 0.993266 1.00338 TMEM241 - Transmembrane protein 241 - Homo sapiens (Human) - TMEM241 gene Golgi apparatus, antiporter activity Taurus_UMD|evm.model.AC_000181.1.164 Q8TDN4 CABL1_HUMAN 95.413 0.977528 0.703002 CABLES1 - CDK5 and ABL1 enzyme substrate 1 - Homo sapiens (Human) - CABLES1 gene Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). Taurus_UMD|evm.model.AC_000181.1.165 A6QNQ6 CTIP_BOVIN 98.555 0.847269 1.18494 RBBP8 - DNA endonuclease RBBP8 - Bos taurus (Bovine) - RBBP8 gene Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (By similarity). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Taurus_UMD|evm.model.AC_000181.1.168 Q95JA5 GATA6_PIG 92.879 0.993808 0.716186 GATA6 - Transcription factor GATA-6 - Sus scrofa (Pig) - GATA6 gene Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Taurus_UMD|evm.model.AC_000181.1.169 Q95JA5 GATA6_PIG 96.226 0.230088 0.501109 GATA6 - Transcription factor GATA-6 - Sus scrofa (Pig) - GATA6 gene Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Taurus_UMD|evm.model.AC_000181.1.170 P16423 POLR_DROME 31.579 0.396783 0.352886 pol - Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM - Drosophila melanogaster (Fruit fly) - pol gene Taurus_UMD|evm.model.AC_000181.1.171 Q86YT6 MIB1_HUMAN 94.533 0.997908 0.950298 MIB1 - E3 ubiquitin-protein ligase MIB1 - Homo sapiens (Human) - MIB1 gene E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. Taurus_UMD|evm.model.AC_000181.1.172 Q0VC00 ABHD3_BOVIN 70.283 0.99446 0.878345 ABHD3 - Phospholipase ABHD3 - Bos taurus (Bovine) - ABHD3 gene Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids. Taurus_UMD|evm.model.AC_000181.1.173 P62315 SMD1_MOUSE 100.000 0.983333 1.0084 Snrpd1 - Small nuclear ribonucleoprotein Sm D1 - Mus musculus (Mouse) - Snrpd1 gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. Taurus_UMD|evm.model.AC_000181.1.175 Q5FWF5 ESCO1_HUMAN 83.943 0.997625 1.00238 ESCO1 - N-acetyltransferase ESCO1 - Homo sapiens (Human) - ESCO1 gene Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053). Taurus_UMD|evm.model.AC_000181.1.176 Q9C091 GRB1L_HUMAN 95.626 0.37807 0.910556 GREB1L - GREB1-like protein - Homo sapiens (Human) - GREB1L gene Plays a major role in early metanephros and genital development. Taurus_UMD|evm.model.AC_000181.1.177 Q04941 PLP2_HUMAN 67.883 0.984733 0.861842 PLP2 - Proteolipid protein 2 - Homo sapiens (Human) - PLP2 gene May play a role in cell differentiation in the intestinal epithelium. Taurus_UMD|evm.model.AC_000181.1.178 O77819 ROCK1_RABIT 97.932 0.998524 1.00074 ROCK1 - Rho-associated protein kinase 1 - Oryctolagus cuniculus (Rabbit) - ROCK1 gene Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity) (PubMed:9139666). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By similarity). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). Taurus_UMD|evm.model.AC_000181.1.179 Q0IIF7 UBP14_BOVIN 92.713 0.995643 0.92915 USP14 - Ubiquitin carboxyl-terminal hydrolase 14 - Bos taurus (Bovine) - USP14 gene Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation. Taurus_UMD|evm.model.AC_000181.1.180 Q96FV9 THOC1_HUMAN 97.565 0.99696 1.00152 THOC1 - THO complex subunit 1 - Homo sapiens (Human) - THOC1 gene Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation. Taurus_UMD|evm.model.AC_000181.1.181 A6QP79 COL12_BOVIN 100.000 0.997308 1.00135 COLEC12 - Collectin-12 - Bos taurus (Bovine) - COLEC12 gene Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR) (By similarity). Taurus_UMD|evm.model.AC_000181.1.182 Q32LE3 CETN1_BOVIN 100.000 0.988439 1.00581 CETN1 - Centrin-1 - Bos taurus (Bovine) - CETN1 gene Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation (By similarity). Taurus_UMD|evm.model.AC_000181.1.183 Q3ZRW9 CLUL1_BOVIN 99.570 0.995708 1.00215 CLUL1 - Clusterin-like protein 1 precursor - Bos taurus (Bovine) - CLUL1 gene extracellular space, nucleus, misfolded protein binding Taurus_UMD|evm.model.AC_000181.1.184 P07607 TYSY_MOUSE 90.000 0.943218 1.03257 Tyms - Thymidylate synthase - Mus musculus (Mouse) - Tyms gene Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Taurus_UMD|evm.model.AC_000181.1.185 Q2KIA9 ENOF1_BOVIN 100.000 0.995495 1.00226 ENOSF1 - Mitochondrial enolase superfamily member 1 - Bos taurus (Bovine) - ENOSF1 gene Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion. May down-regulate thymidylate synthase activity, possibly already at the RNA level, by promoting the degradation of TYMS mRNA via an antisense RNA-based mechanism. Taurus_UMD|evm.model.AC_000181.1.186 P07947 YES_HUMAN 96.869 0.99631 0.998158 YES1 - Tyrosine-protein kinase Yes - Homo sapiens (Human) - YES1 gene Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Taurus_UMD|evm.model.AC_000181.1.188 P16613 PACA_SHEEP 97.159 0.988701 1.00568 ADCYAP1 - Pituitary adenylate cyclase-activating polypeptide precursor - Ovis aries (Sheep) - ADCYAP1 gene Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). Taurus_UMD|evm.model.AC_000181.1.189 P62630 EF1A1_RAT 79.233 0.992718 0.891775 Eef1a1 - Elongation factor 1-alpha 1 - Rattus norvegicus (Rat) - Eef1a1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000181.1.193 Q8N3J2 METL4_HUMAN 82.203 0.995745 0.995763 METTL4 - N(6)-adenine-specific methyltransferase METTL4 - Homo sapiens (Human) - METTL4 gene N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA (PubMed:31913360, PubMed:32183942). Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U2 small nuclear RNA (snRNA): methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation (PubMed:31913360). Internal m6A(m) methylation of snRNAs regulates RNA splicing (PubMed:31913360). Also able to act as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (PubMed:32183942). The existence of N(6)-methyladenosine (m6A) on DNA is however unclear in mammals, and additional evidences are required to confirm the role of the N(6)-adenine-specific DNA methyltransferase activity of METTL4 in vivo (PubMed:32203414). Acts as a regulator of mitochondrial transcript levels and mitochondrial DNA (mtDNA) copy number by mediating mtDNA N(6)-methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA-binding and bending (PubMed:32183942). N(6)-methyladenosine deposition by METTL4 regulates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (By similarity). Taurus_UMD|evm.model.AC_000181.1.194 O14777 NDC80_HUMAN 90.654 0.972686 1.02648 NDC80 - Kinetochore protein NDC80 homolog - Homo sapiens (Human) - NDC80 gene Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108). Taurus_UMD|evm.model.AC_000181.1.195 A8D8X1 RL10_SHEEP 77.083 0.482051 0.911215 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000181.1.196 A6NHR9 SMHD1_HUMAN 92.775 0.994494 0.996509 SMCHD1 - Structural maintenance of chromosomes flexible hinge domain-containing protein 1 - Homo sapiens (Human) - SMCHD1 gene Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:25294876, PubMed:24790221). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876). Taurus_UMD|evm.model.AC_000181.1.197 Q9BXX0 EMIL2_HUMAN 90.643 0.186404 0.866097 EMILIN2 - EMILIN-2 precursor - Homo sapiens (Human) - EMILIN2 gene May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity. Taurus_UMD|evm.model.AC_000181.1.199 Q92539 LPIN2_HUMAN 88.616 0.920207 1.07701 LPIN2 - Phosphatidate phosphatase LPIN2 - Homo sapiens (Human) - LPIN2 gene Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. Taurus_UMD|evm.model.AC_000181.1.200 P52179 MYOM1_HUMAN 83.709 0.99814 0.95727 MYOM1 - Myomesin-1 - Homo sapiens (Human) - MYOM1 gene Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. Taurus_UMD|evm.model.AC_000181.1.201 Q5E9E2 MYL9_BOVIN 100.000 0.655172 1.51744 MYL9 - Myosin regulatory light polypeptide 9 - Bos taurus (Bovine) - MYL9 gene Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity). Taurus_UMD|evm.model.AC_000181.1.202 Q15583 TGIF1_HUMAN 89.706 0.992674 0.680798 TGIF1 - Homeobox protein TGIF1 - Homo sapiens (Human) - TGIF1 gene Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. Taurus_UMD|evm.model.AC_000181.1.203 O14490 DLGP1_HUMAN 96.353 0.997976 1.01126 DLGAP1 - Disks large-associated protein 1 - Homo sapiens (Human) - DLGAP1 gene Part of the postsynaptic scaffold in neuronal cells. Taurus_UMD|evm.model.AC_000181.1.206 P50894 RS7_TAKRU 82.432 0.973333 0.386598 rps7 - 40S ribosomal protein S7 - Takifugu rubripes (Japanese pufferfish) - rps7 gene Taurus_UMD|evm.model.AC_000181.1.207 P0CW23 AKAI1_HUMAN 66.667 0.706522 1.33333 AKAIN1 - A-kinase anchor protein inhibitor 1 - Homo sapiens (Human) - AKAIN1 gene Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA (PubMed:25653177). Taurus_UMD|evm.model.AC_000181.1.209 O43829 ZBT14_HUMAN 99.332 0.995556 1.00223 ZBTB14 - Zinc finger and BTB domain-containing protein 14 - Homo sapiens (Human) - ZBTB14 gene Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters. Taurus_UMD|evm.model.AC_000181.1.210 Q9Y2J2 E41L3_HUMAN 89.454 0.592179 0.823367 EPB41L3 - Band 4.1-like protein 3 - Homo sapiens (Human) - EPB41L3 gene Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. Taurus_UMD|evm.model.AC_000181.1.215 A6NKL6 T200C_HUMAN 87.912 0.171103 0.847021 TMEM200C - Transmembrane protein 200C - Homo sapiens (Human) - TMEM200C gene Taurus_UMD|evm.model.AC_000181.1.217 Q9P2N2 RHG28_HUMAN 80.896 0.973042 1.06859 ARHGAP28 - Rho GTPase-activating protein 28 - Homo sapiens (Human) - ARHGAP28 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000181.1.218 P25391 LAMA1_HUMAN 77.952 0.994065 0.986341 LAMA1 - Laminin subunit alpha-1 precursor - Homo sapiens (Human) - LAMA1 gene Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Taurus_UMD|evm.model.AC_000181.1.219 A6NM36 LRC30_HUMAN 82.450 0.993377 1.00332 LRRC30 - Leucine-rich repeat-containing protein 30 - Homo sapiens (Human) - LRRC30 gene cytoplasm, intracellular membrane-bounded organelle, protein serine/threonine phosphatase activity, signal transduction Taurus_UMD|evm.model.AC_000181.1.220 P28827 PTPRM_HUMAN 97.383 0.998623 1 PTPRM - Receptor-type tyrosine-protein phosphatase mu precursor - Homo sapiens (Human) - PTPRM gene Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control. Taurus_UMD|evm.model.AC_000181.1.221 P35283 RAB12_MOUSE 98.817 0.308824 2.23868 Rab12 - Ras-related protein Rab-12 - Mus musculus (Mouse) - Rab12 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy. Taurus_UMD|evm.model.AC_000181.1.222 Q9Y4B5 MTCL1_HUMAN 76.335 0.969841 0.992126 MTCL1 - Microtubule cross-linking factor 1 - Homo sapiens (Human) - MTCL1 gene Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Taurus_UMD|evm.model.AC_000181.1.223 P04394 NDUV2_BOVIN 100.000 0.992 1.00402 NDUFV2 - NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor - Bos taurus (Bovine) - NDUFV2 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Taurus_UMD|evm.model.AC_000181.1.224 Q6UB98 ANR12_HUMAN 86.641 0.999014 0.983511 ANKRD12 - Ankyrin repeat domain-containing protein 12 - Homo sapiens (Human) - ANKRD12 gene May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Taurus_UMD|evm.model.AC_000181.1.225 Q98T89 TWSG1_CHICK 98.000 0.888393 1 TWSG1 - Twisted gastrulation protein homolog 1 precursor - Gallus gallus (Chicken) - TWSG1 gene May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). Taurus_UMD|evm.model.AC_000181.1.227 Q15311 RBP1_HUMAN 90.382 0.996855 0.970992 RALBP1 - RalA-binding protein 1 - Homo sapiens (Human) - RALBP1 gene Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). Taurus_UMD|evm.model.AC_000181.1.228 Q8TF05 PP4R1_HUMAN 83.957 0.987097 0.978947 PPP4R1 - Serine/threonine-protein phosphatase 4 regulatory subunit 1 - Homo sapiens (Human) - PPP4R1 gene Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Taurus_UMD|evm.model.AC_000181.1.229 Q6GQP4 RAB31_RAT 96.175 0.846512 1.10825 Rab31 - Ras-related protein Rab-31 - Rattus norvegicus (Rat) - Rab31 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Taurus_UMD|evm.model.AC_000181.1.230 P82460 THIO_PIG 60.577 0.158706 6.18095 TXN - Thioredoxin - Sus scrofa (Pig) - TXN gene Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity). Taurus_UMD|evm.model.AC_000181.1.231 Q0VCY1 VAPA_BOVIN 81.973 0.99322 1.18474 VAPA - Vesicle-associated membrane protein-associated protein A - Bos taurus (Bovine) - VAPA gene Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. Taurus_UMD|evm.model.AC_000181.1.233 Q8J025 APCD1_HUMAN 87.898 0.930693 0.98249 APCDD1 - Protein APCDD1 precursor - Homo sapiens (Human) - APCDD1 gene Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis. Taurus_UMD|evm.model.AC_000181.1.234 P81127 SNAG_BOVIN 100.000 0.787342 1.26603 NAPG - Gamma-soluble NSF attachment protein - Bos taurus (Bovine) - NAPG gene Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Taurus_UMD|evm.model.AC_000181.1.235 Q8CD54 PIEZ2_MOUSE 90.685 0.129768 0.993976 Piezo2 - Piezo-type mechanosensitive ion channel component 2 - Mus musculus (Mouse) - Piezo2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:20813920, PubMed:24717433). Required for Merkel-cell mechanotransduction (PubMed:24717433). Plays a major role in light-touch mechanosensation (PubMed:25471886). Taurus_UMD|evm.model.AC_000181.1.239 Q8CGK7 GNAL_MOUSE 88.976 0.994135 0.895013 Gnal - Guanine nucleotide-binding protein G(olf) subunit alpha - Mus musculus (Mouse) - Gnal gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters (By similarity). Taurus_UMD|evm.model.AC_000181.1.240 D2I2M6 MPPE1_AILME 74.436 0.896163 1.1301 MPPE1 - Metallophosphoesterase 1 - Ailuropoda melanoleuca (Giant panda) - MPPE1 gene Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity). Taurus_UMD|evm.model.AC_000181.1.241 O14732 IMPA2_HUMAN 80.208 0.992647 0.944444 IMPA2 - Inositol monophosphatase 2 - Homo sapiens (Human) - IMPA2 gene Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain. Taurus_UMD|evm.model.AC_000181.1.242 O60543 CIDEA_HUMAN 88.182 0.698718 0.712329 CIDEA - Cell death activator CIDE-A - Homo sapiens (Human) - CIDEA gene Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear. Taurus_UMD|evm.model.AC_000181.1.243 O60543 CIDEA_HUMAN 72.340 0.314189 1.3516 CIDEA - Cell death activator CIDE-A - Homo sapiens (Human) - CIDEA gene Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear. Taurus_UMD|evm.model.AC_000181.1.244 Q2HJ81 TBB6_BOVIN 100.000 0.933862 0.847534 TUBB6 - Tubulin beta-6 chain - Bos taurus (Bovine) - TUBB6 gene Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Taurus_UMD|evm.model.AC_000181.1.245 Q2KJI7 AFG32_BOVIN 100.000 0.997519 1.00124 AFG3L2 - AFG3-like protein 2 precursor - Bos taurus (Bovine) - AFG3L2 gene ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (By similarity). Involved in the regulation of OMA1-dependent processing of OPA1 (By similarity). Taurus_UMD|evm.model.AC_000181.1.246 Q96N28 PLD3A_HUMAN 89.535 0.695122 1.43023 PRELID3A - PRELI domain containing protein 3A - Homo sapiens (Human) - PRELID3A gene In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane. Taurus_UMD|evm.model.AC_000181.1.248 Q4R707 SPIR1_MACFA 90.240 0.805249 1.23973 SPIRE1 - Protein spire homolog 1 - Macaca fascicularis (Crab-eating macaque) - SPIRE1 gene Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. Taurus_UMD|evm.model.AC_000181.1.249 Q8TAP6 CEP76_HUMAN 96.520 0.996979 1.00455 CEP76 - Centrosomal protein of 76 kDa - Homo sapiens (Human) - CEP76 gene Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication. Taurus_UMD|evm.model.AC_000181.1.250 Q2NL24 PSMG2_BOVIN 100.000 0.992453 1.00379 PSMG2 - Proteasome assembly chaperone 2 - Bos taurus (Bovine) - PSMG2 gene Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity). Taurus_UMD|evm.model.AC_000181.1.251 P17706 PTN2_HUMAN 90.052 0.979434 0.937349 PTPN2 - Tyrosine-protein phosphatase non-receptor type 2 - Homo sapiens (Human) - PTPN2 gene Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA. Taurus_UMD|evm.model.AC_000181.1.252 A7YY75 SEH1_BOVIN 100.000 0.843602 1.17222 SEH1L - Nucleoporin SEH1 - Bos taurus (Bovine) - SEH1L gene Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. Taurus_UMD|evm.model.AC_000181.1.253 Q9NZV8 KCND2_HUMAN 77.215 0.0304926 4.06032 KCND2 - Potassium voltage-gated channel subfamily D member 2 - Homo sapiens (Human) - KCND2 gene Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:15454437, PubMed:14695263, PubMed:14623880, PubMed:14980201, PubMed:16934482, PubMed:24811166, PubMed:24501278). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:15454437, PubMed:14623880, PubMed:14980201, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity). Taurus_UMD|evm.model.AC_000181.1.255 O15165 LRAD4_HUMAN 77.632 0.980519 1.00654 LDLRAD4 - Low-density lipoprotein receptor class A domain-containing protein 4 - Homo sapiens (Human) - LDLRAD4 gene Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. Taurus_UMD|evm.model.AC_000181.1.256 Q05B67 F210A_BOVIN 99.251 0.808511 1.20513 FAM210A - Protein FAM210A - Bos taurus (Bovine) - FAM210A gene May play a role in the structure and strength of both muscle and bone. Taurus_UMD|evm.model.AC_000181.1.257 Q4R7K1 MCES_MACFA 86.402 0.995816 1.0042 RNMT - mRNA cap guanine-N7 methyltransferase - Macaca fascicularis (Crab-eating macaque) - RNMT gene Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC. Taurus_UMD|evm.model.AC_000181.1.258 P56451 MC5R_BOVIN 100.000 0.993865 1.00308 MC5R - Melanocortin receptor 5 - Bos taurus (Bovine) - MC5R gene Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins (By similarity). Taurus_UMD|evm.model.AC_000181.1.259 P34974 ACTHR_BOVIN 100.000 0.993289 1.00337 MC2R - Adrenocorticotropic hormone receptor - Bos taurus (Bovine) - MC2R gene Receptor for corticotropin (ACTH). This receptor is mediated by G proteins which activate adenylate cyclase (cAMP). Taurus_UMD|evm.model.AC_000181.1.260 P15103 GLNA_BOVIN 95.710 0.994638 1 GLUL - Glutamine synthetase - Bos taurus (Bovine) - GLUL gene Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). Taurus_UMD|evm.model.AC_000181.1.261 Q9H5I5 PIEZ2_HUMAN 89.655 0.345679 0.0294331 PIEZO2 - Piezo-type mechanosensitive ion channel component 2 - Homo sapiens (Human) - PIEZO2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. Taurus_UMD|evm.model.AC_000181.1.262 Q9H5I5 PIEZ2_HUMAN 88.312 0.329004 0.083939 PIEZO2 - Piezo-type mechanosensitive ion channel component 2 - Homo sapiens (Human) - PIEZO2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. Taurus_UMD|evm.model.AC_000181.1.264 Q28614 UT2_RABIT 90.176 0.425349 2.34509 SLC14A2 - Urea transporter 2 - Oryctolagus cuniculus (Rabbit) - SLC14A2 gene Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. Taurus_UMD|evm.model.AC_000181.1.265 Q5QF96 UT1_BOVIN 100.000 0.870455 1.14583 SLC14A1 - Urea transporter 1 - Bos taurus (Bovine) - SLC14A1 gene Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means. Taurus_UMD|evm.model.AC_000181.1.266 Q6ZMC9 SIG15_HUMAN 81.053 0.782369 1.10671 SIGLEC15 - Sialic acid-binding Ig-like lectin 15 precursor - Homo sapiens (Human) - SIGLEC15 gene Binds sialylated glycoproteins. Taurus_UMD|evm.model.AC_000181.1.267 Q9HCE0 EPG5_HUMAN 90.423 0.999225 1 EPG5 - Ectopic P granules protein 5 homolog - Homo sapiens (Human) - EPG5 gene Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located (PubMed:29130391). Taurus_UMD|evm.model.AC_000181.1.268 Q9H939 PPIP2_HUMAN 87.164 0.99403 1.00299 PSTPIP2 - Proline-serine-threonine phosphatase-interacting protein 2 - Homo sapiens (Human) - PSTPIP2 gene Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity). Taurus_UMD|evm.model.AC_000181.1.269 P19483 ATPA_BOVIN 99.819 0.99639 1.00181 ATP5F1A - ATP synthase subunit alpha, mitochondrial precursor - Bos taurus (Bovine) - ATP5F1A gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity). Taurus_UMD|evm.model.AC_000181.1.270 Q2TBK4 HAUS1_BOVIN 100.000 0.992832 1.0036 HAUS1 - HAUS augmin-like complex subunit 1 - Bos taurus (Bovine) - HAUS1 gene Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Taurus_UMD|evm.model.AC_000181.1.271 Q5R4B7 CR025_PONAB 98.810 0.26183 1.15273 Uncharacterized protein C18orf25 homolog - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000181.1.272 Q6ZSG1 RN165_HUMAN 97.853 0.944767 0.99422 RNF165 - E3 ubiquitin-protein ligase RNF165 - Homo sapiens (Human) - RNF165 gene E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. Taurus_UMD|evm.model.AC_000181.1.273 Q8IVV2 LOXH1_HUMAN 86.854 0.583593 1.08515 LOXHD1 - Lipoxygenase homology domain-containing protein 1 - Homo sapiens (Human) - LOXHD1 gene Involved in hearing. Required for normal function of hair cells in the inner ear (By similarity). Taurus_UMD|evm.model.AC_000181.1.275 O15466 SIA8E_HUMAN 97.640 0.78972 1.1383 ST8SIA5 - Alpha-2,8-sialyltransferase 8E - Homo sapiens (Human) - ST8SIA5 gene Involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, GP1c and GT3 from GD1a, GT1b, GM1b and GD3 respectively. Taurus_UMD|evm.model.AC_000181.1.276 O75928 PIAS2_HUMAN 97.390 0.948837 1.03865 PIAS2 - E3 SUMO-protein ligase PIAS2 - Homo sapiens (Human) - PIAS2 gene Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'. Taurus_UMD|evm.model.AC_000181.1.277 Q14241 ELOA1_HUMAN 66.755 0.99458 0.462406 ELOA - Elongin-A - Homo sapiens (Human) - ELOA gene SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). Taurus_UMD|evm.model.AC_000181.1.278 Q14241 ELOA1_HUMAN 40.000 0.992701 0.343358 ELOA - Elongin-A - Homo sapiens (Human) - ELOA gene SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). Taurus_UMD|evm.model.AC_000181.1.279 Q3ZCH9 HDHD2_BOVIN 94.853 0.209302 2.49035 HDHD2 - Haloacid dehalogenase-like hydrolase domain-containing protein 2 - Bos taurus (Bovine) - HDHD2 gene enzyme binding, phosphatase activity, dephosphorylation Taurus_UMD|evm.model.AC_000181.1.280 Q3ZCH9 HDHD2_BOVIN 100.000 0.873333 0.579151 HDHD2 - Haloacid dehalogenase-like hydrolase domain-containing protein 2 - Bos taurus (Bovine) - HDHD2 gene enzyme binding, phosphatase activity, dephosphorylation Taurus_UMD|evm.model.AC_000181.1.281 Q9Y5U9 IR3IP_HUMAN 98.630 0.0818182 10.7317 IER3IP1 - Immediate early response 3-interacting protein 1 - Homo sapiens (Human) - IER3IP1 gene Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size (PubMed:33122427). Required for secretion of extracellular matrix proteins (PubMed:33122427). Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors (PubMed:33122427). Acts as a regulator of the unfolded protein response (UPR) (By similarity). Taurus_UMD|evm.model.AC_000181.1.284 Q62432 SMAD2_MOUSE 93.576 0.995434 0.937901 Smad2 - Mothers against decapentaplegic homolog 2 - Mus musculus (Mouse) - Smad2 gene Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). Taurus_UMD|evm.model.AC_000181.1.285 A1YPR0 ZBT7C_HUMAN 89.984 0.996593 0.948304 ZBTB7C - Zinc finger and BTB domain-containing protein 7C - Homo sapiens (Human) - ZBTB7C gene May be a tumor suppressor gene. Taurus_UMD|evm.model.AC_000181.1.289 O43310 CTIF_HUMAN 92.333 0.996672 1.00502 CTIF - CBP80/20-dependent translation initiation factor - Homo sapiens (Human) - CTIF gene Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). Taurus_UMD|evm.model.AC_000181.1.292 O15105 SMAD7_HUMAN 92.254 0.995025 0.943662 SMAD7 - Mothers against decapentaplegic homolog 7 - Homo sapiens (Human) - SMAD7 gene Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Taurus_UMD|evm.model.AC_000181.1.294 Q7RTS9 DYM_HUMAN 97.285 0.725082 1.36472 DYM - Dymeclin - Homo sapiens (Human) - DYM gene Necessary for correct organization of Golgi apparatus. Involved in bone development. Taurus_UMD|evm.model.AC_000181.1.295 Q3ZC78 CR032_BOVIN 86.567 0.636364 1.30263 UPF0729 protein C18orf32 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000181.1.296 P24049 RL17_RAT 100.000 0.989189 1.00543 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000181.1.298 Q9Y5X9 LIPE_HUMAN 85.167 0.90708 0.452 LIPG - Endothelial lipase precursor - Homo sapiens (Human) - LIPG gene Exerts both phospholipase and triglyceride lipase activities (PubMed:12032167, PubMed:10318835, PubMed:10192396). More active as a phospholipase than a triglyceride lipase (PubMed:12032167). Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (PubMed:12032167). Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (PubMed:12032167, PubMed:10192396). Taurus_UMD|evm.model.AC_000181.1.299 Q9Y5X9 LIPE_HUMAN 83.333 0.891525 0.59 LIPG - Endothelial lipase precursor - Homo sapiens (Human) - LIPG gene Exerts both phospholipase and triglyceride lipase activities (PubMed:12032167, PubMed:10318835, PubMed:10192396). More active as a phospholipase than a triglyceride lipase (PubMed:12032167). Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (PubMed:12032167). Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (PubMed:12032167, PubMed:10192396). Taurus_UMD|evm.model.AC_000181.1.300 P29391 FRIL1_MOUSE 69.841 0.613861 0.551913 Ftl1 - Ferritin light chain 1 - Mus musculus (Mouse) - Ftl1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Taurus_UMD|evm.model.AC_000181.1.301 Q3T0R7 THIM_BOVIN 100.000 0.994975 1.00252 ACAA2 - 3-ketoacyl-CoA thiolase, mitochondrial - Bos taurus (Bovine) - ACAA2 gene In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activity on various fatty acyl-CoAs (By similarity). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (By similarity). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (By similarity). Taurus_UMD|evm.model.AC_000181.1.302 Q9ULV0 MYO5B_HUMAN 90.000 0.998902 0.98539 MYO5B - Unconventional myosin-Vb - Homo sapiens (Human) - MYO5B gene May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Taurus_UMD|evm.model.AC_000181.1.303 Q9UIS9 MBD1_HUMAN 86.341 0.500423 1.95537 MBD1 - Methyl-CpG-binding domain protein 1 - Homo sapiens (Human) - MBD1 gene Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. Taurus_UMD|evm.model.AC_000181.1.304 Q5EA28 CXXC1_BOVIN 100.000 0.996965 1.00152 CXXC1 - CXXC-type zinc finger protein 1 - Bos taurus (Bovine) - CXXC1 gene Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. Taurus_UMD|evm.model.AC_000181.1.305 Q0V7M7 SKA1_BOVIN 99.587 0.649596 1.46063 SKA1 - Spindle and kinetochore-associated protein 1 - Bos taurus (Bovine) - SKA1 gene Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. In the complex, it mediates the interaction with microtubules. Taurus_UMD|evm.model.AC_000181.1.306 P31152 MK04_HUMAN 92.593 0.996604 1.00341 MAPK4 - Mitogen-activated protein kinase 4 - Homo sapiens (Human) - MAPK4 gene Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). Taurus_UMD|evm.model.AC_000181.1.307 Q58DE2 MSTRO_BOVIN 100.000 0.923695 0.946768 MRO - Protein maestro - Bos taurus (Bovine) - MRO gene Taurus_UMD|evm.model.AC_000181.1.310 P23368 MAOM_HUMAN 91.952 0.996581 1.00171 ME2 - NAD-dependent malic enzyme, mitochondrial precursor - Homo sapiens (Human) - ME2 gene intracellular membrane-bounded organelle, mitochondrial matrix, mitochondrion, electron transfer activity, malate dehydrogenase (decarboxylating) (NAD+) activity, malate dehydrogenase (decarboxylating) (NADP+) activity, malic enzyme activity, malate metabolic process, pyruvate metabolic process, regulation of NADP metabolic process Taurus_UMD|evm.model.AC_000181.1.311 Q29RY4 RNZ1_BOVIN 100.000 0.994505 1.00275 ELAC1 - Zinc phosphodiesterase ELAC protein 1 - Bos taurus (Bovine) - ELAC1 gene Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity). Taurus_UMD|evm.model.AC_000181.1.312 Q1HE26 SMAD4_BOVIN 99.819 0.99639 1.00181 SMAD4 - Mothers against decapentaplegic homolog 4 - Bos taurus (Bovine) - SMAD4 gene Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8 (By similarity). Taurus_UMD|evm.model.AC_000181.1.313 Q5U5Q3 MEX3C_HUMAN 99.355 0.995708 0.707132 MEX3C - RNA-binding E3 ubiquitin-protein ligase MEX3C - Homo sapiens (Human) - MEX3C gene E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. Taurus_UMD|evm.model.AC_000181.1.315 Q9DCR2 AP3S1_MOUSE 89.011 0.947368 0.492228 Ap3s1 - AP-3 complex subunit sigma-1 - Mus musculus (Mouse) - Ap3s1 gene Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Taurus_UMD|evm.model.AC_000181.1.316 Q99877 H2B1N_HUMAN 90.756 0.914729 1.02381 H2BC15 - Histone H2B type 1-N - Homo sapiens (Human) - H2BC15 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000181.1.319 P43146 DCC_HUMAN 96.765 0.874704 0.292329 DCC - Netrin receptor DCC precursor - Homo sapiens (Human) - DCC gene Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Taurus_UMD|evm.model.AC_000181.1.320 P43146 DCC_HUMAN 94.794 0.997775 0.621285 DCC - Netrin receptor DCC precursor - Homo sapiens (Human) - DCC gene Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Taurus_UMD|evm.model.AC_000181.1.321 Q9UBB5 MBD2_HUMAN 96.985 0.99 0.486618 MBD2 - Methyl-CpG-binding domain protein 2 - Homo sapiens (Human) - MBD2 gene Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. Taurus_UMD|evm.model.AC_000181.1.322 Q9UNA4 POLI_HUMAN 83.310 0.965241 1.01081 POLI - DNA polymerase iota - Homo sapiens (Human) - POLI gene Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunogobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940). Taurus_UMD|evm.model.AC_000181.1.323 Q8IYD9 LAS2_HUMAN 85.227 0.330189 1.42473 LAS2 - Lung adenoma susceptibility protein 2 precursor - Homo sapiens (Human) - LAS2 gene Might play a role in cell proliferation. Taurus_UMD|evm.model.AC_000181.1.324 O65252 GL25_ARATH 33.333 0.246253 2.19249 At5g26700 - Probable germin-like protein subfamily 2 member 5 precursor - Arabidopsis thaliana (Mouse-ear cress) - At5g26700 gene May play a role in plant defense. Probably has no oxalate oxidase activity even if the active site is conserved. Taurus_UMD|evm.model.AC_000181.1.325 Q8N1N2 DYNAP_HUMAN 49.630 0.213333 2.85714 DYNAP - Dynactin-associated protein - Homo sapiens (Human) - DYNAP gene Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at 'Ser-473'. Taurus_UMD|evm.model.AC_000181.1.327 Q0II50 USB1_BOVIN 94.949 0.7 0.528302 USB1 - U6 snRNA phosphodiesterase - Bos taurus (Bovine) - USB1 gene Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Taurus_UMD|evm.model.AC_000181.1.329 Q8HZJ5 RB27B_BOVIN 100.000 0.990868 1.00459 RAB27B - Ras-related protein Rab-27B - Bos taurus (Bovine) - RAB27B gene Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes (PubMed:14625374). Taurus_UMD|evm.model.AC_000181.1.330 Q9H2F9 CCD68_HUMAN 81.646 0.872576 1.07761 CCDC68 - Coiled-coil domain-containing protein 68 - Homo sapiens (Human) - CCDC68 gene Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Taurus_UMD|evm.model.AC_000181.1.331 P15881 ITF2_CANLF 97.682 0.96131 1.04673 TCF4 - Transcription factor 4 - Canis lupus familiaris (Dog) - TCF4 gene Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). Binds to the thyroglobulin promoter. Taurus_UMD|evm.model.AC_000181.1.335 O43396 TXNL1_HUMAN 99.654 0.993103 1.00346 TXNL1 - Thioredoxin-like protein 1 - Homo sapiens (Human) - TXNL1 gene Active thioredoxin with a redox potential of about -250 mV. Taurus_UMD|evm.model.AC_000181.1.336 Q9Y4E6 WDR7_HUMAN 94.101 0.979016 0.927517 WDR7 - WD repeat-containing protein 7 - Homo sapiens (Human) - WDR7 gene Taurus_UMD|evm.model.AC_000181.1.339 O43173 SIA8C_HUMAN 93.947 0.994737 1 ST8SIA3 - Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase - Homo sapiens (Human) - ST8SIA3 gene Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid. Taurus_UMD|evm.model.AC_000181.1.340 Q8JZM4 DNER_MOUSE 97.561 0.778846 0.141113 Dner - Delta and Notch-like epidermal growth factor-related receptor precursor - Mus musculus (Mouse) - Dner gene Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling. Taurus_UMD|evm.model.AC_000181.1.341 O95948 ONEC2_HUMAN 97.315 0.993311 0.593254 ONECUT2 - One cut domain family member 2 - Homo sapiens (Human) - ONECUT2 gene Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B. Taurus_UMD|evm.model.AC_000181.1.342 P22600 HEMH_BOVIN 100.000 0.995204 1.0024 FECH - Ferrochelatase, mitochondrial precursor - Bos taurus (Bovine) - FECH gene Catalyzes the ferrous insertion into protoporphyrin IX. Taurus_UMD|evm.model.AC_000181.1.343 Q2KJG3 SYNC_BOVIN 99.821 0.996429 1.00179 NARS - Asparagine--tRNA ligase, cytoplasmic - Bos taurus (Bovine) - NARS gene Taurus_UMD|evm.model.AC_000181.1.344 O43520 AT8B1_HUMAN 91.607 0.998403 1.0008 ATP8B1 - Phospholipid-transporting ATPase IC - Homo sapiens (Human) - ATP8B1 gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:17948906). May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (By similarity). Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (By similarity). Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity (PubMed:20512993). Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2 (PubMed:25239307, PubMed:27301931). Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (By similarity). Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine (PubMed:20510206). Required for the preservation of cochlear hair cells in the inner ear (By similarity). May act as cardiolipin transporter during inflammatory injury (By similarity). Taurus_UMD|evm.model.AC_000181.1.346 Q5RBF2 NED4L_PONAB 98.296 0.997872 0.980188 NEDD4L - E3 ubiquitin-protein ligase NEDD4-like - Pongo abelii (Sumatran orangutan) - NEDD4L gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1. Plays a role in dendrite formation by melanocytes (By similarity). Involved in the regulation of TOR signaling (By similarity). Taurus_UMD|evm.model.AC_000181.1.348 Q86TB3 ALPK2_HUMAN 59.422 0.978674 0.994009 ALPK2 - Alpha-protein kinase 2 - Homo sapiens (Human) - ALPK2 gene Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752). Taurus_UMD|evm.model.AC_000181.1.349 Q9UDY8 MALT1_HUMAN 89.659 0.964747 1.03277 MALT1 - Mucosa-associated lymphoid tissue lymphoma translocation protein 1 - Homo sapiens (Human) - MALT1 gene Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, PubMed:18264101, PubMed:24074955). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753). May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475). Taurus_UMD|evm.model.AC_000181.1.351 Q5RC30 SC11C_PONAB 98.438 0.989637 1.00521 SEC11C - Signal peptidase complex catalytic subunit SEC11C - Pongo abelii (Sumatran orangutan) - SEC11C gene Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Taurus_UMD|evm.model.AC_000181.1.352 Q863C3 GRP_BOVIN 93.985 0.809816 1.21642 GRP - Gastrin-releasing peptide precursor - Bos taurus (Bovine) - GRP gene Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity). Taurus_UMD|evm.model.AC_000181.1.354 Q9Y2V3 RX_HUMAN 85.795 0.994118 0.982659 RAX - Retinal homeobox protein Rx - Homo sapiens (Human) - RAX gene Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter. Taurus_UMD|evm.model.AC_000181.1.355 Q7Z7G2 CPLX4_HUMAN 94.375 0.987578 1.00625 CPLX4 - Complexin-4 precursor - Homo sapiens (Human) - CPLX4 gene Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity). Taurus_UMD|evm.model.AC_000181.1.356 P49257 LMAN1_HUMAN 92.483 0.811111 1.05882 LMAN1 - Protein ERGIC-53 precursor - Homo sapiens (Human) - LMAN1 gene Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Taurus_UMD|evm.model.AC_000181.1.357 Q6UXH8 CCBE1_HUMAN 86.029 0.99511 1.00739 CCBE1 - Collagen and calcium-binding EGF domain-containing protein 1 precursor - Homo sapiens (Human) - CCBE1 gene Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Taurus_UMD|evm.model.AC_000181.1.360 Q13794 APR_HUMAN 69.565 0.4 2.03704 PMAIP1 - Phorbol-12-myristate-13-acetate-induced protein 1 - Homo sapiens (Human) - PMAIP1 gene Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. Taurus_UMD|evm.model.AC_000181.1.362 Q920A7 AFG31_MOUSE 71.582 0.696281 0.613435 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Taurus_UMD|evm.model.AC_000181.1.363 Q9GLJ8 MC4R_BOVIN 100.000 0.993994 1.00301 MC4R - Melanocortin receptor 4 - Bos taurus (Bovine) - MC4R gene Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). Taurus_UMD|evm.model.AC_000181.1.364 P48318 DCE1_MOUSE 65.537 0.910653 0.98145 Gad1 - Glutamate decarboxylase 1 - Mus musculus (Mouse) - Gad1 gene Catalyzes the production of GABA. Taurus_UMD|evm.model.AC_000181.1.365 Q71U00 SKP1_XENLA 100.000 0.975309 0.496933 skp1 - S-phase kinase-associated protein 1 - Xenopus laevis (African clawed frog) - skp1 gene Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). Taurus_UMD|evm.model.AC_000181.1.366 O35737 HNRH1_MOUSE 79.058 0.669014 0.632517 Hnrnph1 - Heterogeneous nuclear ribonucleoprotein H - Mus musculus (Mouse) - Hnrnph1 gene This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) (By similarity). Taurus_UMD|evm.model.AC_000181.1.368 P62828 RAN_RAT 93.671 0.987421 0.736111 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Taurus_UMD|evm.model.AC_000181.1.370 Q9HBT6 CAD20_HUMAN 96.380 0.997506 1.00125 CDH20 - Cadherin-20 precursor - Homo sapiens (Human) - CDH20 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Taurus_UMD|evm.model.AC_000181.1.371 D2H6Z0 RN152_AILME 82.692 0.980952 0.517241 RNF152 - E3 ubiquitin-protein ligase RNF152 - Ailuropoda melanoleuca (Giant panda) - RNF152 gene E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed. Taurus_UMD|evm.model.AC_000181.1.373 O95427 PIGN_HUMAN 80.624 0.995708 1.00107 PIGN - GPI ethanolamine phosphate transferase 1 - Homo sapiens (Human) - PIGN gene Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). May act as suppressor of replication stress and chromosome missegregation. Taurus_UMD|evm.model.AC_000181.1.374 Q9P260 RELCH_HUMAN 93.339 0.998351 0.997533 RELCH - RAB11-binding protein RELCH - Homo sapiens (Human) - RELCH gene Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). Taurus_UMD|evm.model.AC_000181.1.375 Q9Y6Q6 TNR11_HUMAN 64.013 0.871064 1.08279 TNFRSF11A - Tumor necrosis factor receptor superfamily member 11A precursor - Homo sapiens (Human) - TNFRSF11A gene Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. Taurus_UMD|evm.model.AC_000181.1.376 Q9C0B9 ZCHC2_HUMAN 84.600 0.971429 0.445671 ZCCHC2 - Zinc finger CCHC domain-containing protein 2 - Homo sapiens (Human) - ZCCHC2 gene cytoplasm Taurus_UMD|evm.model.AC_000181.1.378 Q9HD36 B2L10_HUMAN 65.385 0.6375 0.392157 BCL2L10 - Bcl-2-like protein 10 - Homo sapiens (Human) - BCL2L10 gene Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (PubMed:11689480, PubMed:11278245). Increases binding of AHCYL1/IRBIT to ITPR1 (PubMed:27995898). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (PubMed:27995898). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). Taurus_UMD|evm.model.AC_000181.1.379 O60346 PHLP1_HUMAN 84.058 0.891223 0.776354 PHLPP1 - PH domain leucine-rich repeat-containing protein phosphatase 1 - Homo sapiens (Human) - PHLPP1 gene Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). Taurus_UMD|evm.model.AC_000181.1.380 P29508 SPB3_HUMAN 62.416 0.936306 0.402564 SERPINB3 - Serpin B3 - Homo sapiens (Human) - SERPINB3 gene May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). Taurus_UMD|evm.model.AC_000181.1.384 O02718 BCL2_BOVIN 99.563 0.991304 1.00437 BCL2 - Apoptosis regulator Bcl-2 - Bos taurus (Bovine) - BCL2 gene Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). Taurus_UMD|evm.model.AC_000181.1.385 Q2KIJ5 KDSR_BOVIN 98.020 0.967949 0.942598 KDSR - 3-ketodihydrosphingosine reductase precursor - Bos taurus (Bovine) - KDSR gene Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). Taurus_UMD|evm.model.AC_000181.1.386 Q0VD48 VPS4B_BOVIN 100.000 0.995506 1.00225 VPS4B - Vacuolar protein sorting-associated protein 4B - Bos taurus (Bovine) - VPS4B gene Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Involved in cytokinesis. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Taurus_UMD|evm.model.AC_000181.1.387 P36952 SPB5_HUMAN 91.200 0.994681 1.00267 SERPINB5 - Serpin B5 - Homo sapiens (Human) - SERPINB5 gene Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Taurus_UMD|evm.model.AC_000181.1.388 Q96P63 SPB12_HUMAN 76.235 0.995305 1.05185 SERPINB12 - Serpin B12 - Homo sapiens (Human) - SERPINB12 gene Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator. Taurus_UMD|evm.model.AC_000181.1.389 Q9UIV8 SPB13_HUMAN 67.008 0.994505 0.930946 SERPINB13 - Serpin B13 - Homo sapiens (Human) - SERPINB13 gene May play a role in the proliferation or differentiation of keratinocytes. Taurus_UMD|evm.model.AC_000181.1.390 A9RA96 SPB10_PAPAN 55.556 0.705263 0.478589 SERPINB10 - Serpin B10 - Papio anubis (Olive baboon) - SERPINB10 gene Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity). Taurus_UMD|evm.model.AC_000181.1.391 P48594 SPB4_HUMAN 65.473 0.994898 1.00513 SERPINB4 - Serpin B4 - Homo sapiens (Human) - SERPINB4 gene May act as a protease inhibitor to modulate the host immune response against tumor cells. Taurus_UMD|evm.model.AC_000181.1.392 P29508 SPB3_HUMAN 65.421 0.679406 1.20769 SERPINB3 - Serpin B3 - Homo sapiens (Human) - SERPINB3 gene May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). Taurus_UMD|evm.model.AC_000181.1.393 P48594 SPB4_HUMAN 62.784 0.993865 0.835897 SERPINB4 - Serpin B4 - Homo sapiens (Human) - SERPINB4 gene May act as a protease inhibitor to modulate the host immune response against tumor cells. Taurus_UMD|evm.model.AC_000181.1.394 P48594 SPB4_HUMAN 66.964 0.973761 0.879487 SERPINB4 - Serpin B4 - Homo sapiens (Human) - SERPINB4 gene May act as a protease inhibitor to modulate the host immune response against tumor cells. Taurus_UMD|evm.model.AC_000181.1.395 P48594 SPB4_HUMAN 64.194 0.994872 1 SERPINB4 - Serpin B4 - Homo sapiens (Human) - SERPINB4 gene May act as a protease inhibitor to modulate the host immune response against tumor cells. Taurus_UMD|evm.model.AC_000181.1.396 Q96P15 SPB11_HUMAN 72.959 0.994737 0.969388 SERPINB11 - Serpin B11 - Homo sapiens (Human) - SERPINB11 gene Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change. Taurus_UMD|evm.model.AC_000181.1.397 O75635 SPB7_HUMAN 79.528 0.994764 1.00526 SERPINB7 - Serpin B7 - Homo sapiens (Human) - SERPINB7 gene Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin. Taurus_UMD|evm.model.AC_000181.1.398 E2RVI8 OVAL_DRONO 40.360 0.994805 0.997409 SERPINB14 - Ovalbumin - Dromaius novaehollandiae (Emu) - SERPINB14 gene Storage protein of egg white. Lacks protease inhibitory activity (By similarity). Taurus_UMD|evm.model.AC_000181.1.399 P05120 PAI2_HUMAN 76.923 0.995204 1.00482 SERPINB2 - Plasminogen activator inhibitor 2 precursor - Homo sapiens (Human) - SERPINB2 gene Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Taurus_UMD|evm.model.AC_000181.1.400 A5PJK0 SPB10_BOVIN 100.000 0.994975 1.00252 SERPINB10 - Serpin B10 - Bos taurus (Bovine) - SERPINB10 gene Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity). Taurus_UMD|evm.model.AC_000182.1.1 Q5E975 TM230_BOVIN 91.667 0.983471 1.00833 TMEM230 - Transmembrane protein 230 - Bos taurus (Bovine) - TMEM230 gene Involved in trafficking and recycling of synaptic vesicles. Taurus_UMD|evm.model.AC_000182.1.2 Q13136 LIPA1_HUMAN 70.513 0.241379 0.265391 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000182.1.3 Q5E9I1 CCNG1_BOVIN 99.371 0.9875 0.542373 CCNG1 - Cyclin-G1 - Bos taurus (Bovine) - CCNG1 gene May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity). Taurus_UMD|evm.model.AC_000182.1.4 Q01113 IL9R_HUMAN 64.691 0.820296 0.907869 IL9R - Interleukin-9 receptor precursor - Homo sapiens (Human) - IL9R gene This is a receptor for interleukin-9. Taurus_UMD|evm.model.AC_000182.1.6 Q9CQZ7 RPC10_MOUSE 99.074 0.981651 1.00926 Polr3k - DNA-directed RNA polymerase III subunit RPC10 - Mus musculus (Mouse) - Polr3k gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Taurus_UMD|evm.model.AC_000182.1.7 Q3ZBQ4 SNR25_BOVIN 100.000 0.61 1.62602 SNRNP25 - U11/U12 small nuclear ribonucleoprotein 25 kDa protein - Bos taurus (Bovine) - SNRNP25 gene U12-type spliceosomal complex Taurus_UMD|evm.model.AC_000182.1.8 A7YWH9 RHDF1_BOVIN 100.000 0.997666 1.00117 RHBDF1 - Inactive rhomboid protein 1 - Bos taurus (Bovine) - RHBDF1 gene Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. Taurus_UMD|evm.model.AC_000182.1.10 P29372 3MG_HUMAN 75.088 0.756303 1.19799 MPG - DNA-3-methyladenine glycosylase precursor - Homo sapiens (Human) - MPG gene Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. Taurus_UMD|evm.model.AC_000182.1.11 Q8VIJ8 NPRL3_MOUSE 92.091 0.996473 0.996485 Nprl3 - GATOR complex protein NPRL3 - Mus musculus (Mouse) - Nprl3 gene As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. Taurus_UMD|evm.model.AC_000182.1.13 P13786 HBAZ_CAPHI 95.070 0.986014 1.00704 HBZ1 - Hemoglobin subunit zeta - Capra hircus (Goat) - HBZ1 gene The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin. Taurus_UMD|evm.model.AC_000182.1.14 P13786 HBAZ_CAPHI 98.077 0.78626 0.922535 HBZ1 - Hemoglobin subunit zeta - Capra hircus (Goat) - HBZ1 gene The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin. Taurus_UMD|evm.model.AC_000182.1.15 A1A4Q3 HBM_BOVIN 100.000 0.985915 1.00709 HBM - Hemoglobin subunit mu - Bos taurus (Bovine) - HBM gene haptoglobin-hemoglobin complex, hemoglobin complex, heme binding, organic acid binding, oxygen binding, oxygen carrier activity, hydrogen peroxide catabolic process Taurus_UMD|evm.model.AC_000182.1.16 P01966 HBA_BOVIN 100.000 0.986014 1.00704 HBA - Hemoglobin subunit alpha - Bos taurus (Bovine) - HBA gene Involved in oxygen transport from the lung to the various peripheral tissues. Taurus_UMD|evm.model.AC_000182.1.17 P01966 HBA_BOVIN 100.000 0.986014 1.00704 HBA - Hemoglobin subunit alpha - Bos taurus (Bovine) - HBA gene Involved in oxygen transport from the lung to the various peripheral tissues. Taurus_UMD|evm.model.AC_000182.1.18 P06890 HBAT_PONPY 74.638 0.958042 1.00704 HBQ1 - Hemoglobin subunit theta-1 - Pongo pygmaeus (Bornean orangutan) - HBQ1 gene Taurus_UMD|evm.model.AC_000182.1.19 P62305 RUXE_MOUSE 89.130 0.978495 1.01087 Snrpe - Small nuclear ribonucleoprotein E - Mus musculus (Mouse) - Snrpe gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. Taurus_UMD|evm.model.AC_000182.1.20 Q9NQ29 LUC7L_HUMAN 97.844 0.994624 1.0027 LUC7L - Putative RNA-binding protein Luc7-like 1 - Homo sapiens (Human) - LUC7L gene May bind to RNA via its Arg/Ser-rich domain. Taurus_UMD|evm.model.AC_000182.1.21 Q2HJE5 F234A_BOVIN 100.000 0.996383 1.00181 FAM234A - Protein FAM234A - Bos taurus (Bovine) - FAM234A gene cell surface Taurus_UMD|evm.model.AC_000182.1.22 O94810 RGS11_HUMAN 80.044 0.957082 0.997859 RGS11 - Regulator of G-protein signaling 11 - Homo sapiens (Human) - RGS11 gene Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Taurus_UMD|evm.model.AC_000182.1.23 Q0II80 GDIR3_BOVIN 100.000 0.77821 1.14222 ARHGDIG - Rho GDP-dissociation inhibitor 3 - Bos taurus (Bovine) - ARHGDIG gene Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP (By similarity). Taurus_UMD|evm.model.AC_000182.1.24 Q5RCH2 PDIA2_PONAB 84.017 0.847706 1.0381 PDIA2 - Protein disulfide-isomerase A2 precursor - Pongo abelii (Sumatran orangutan) - PDIA2 gene Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins (By similarity). Taurus_UMD|evm.model.AC_000182.1.25 O35625 AXIN1_MOUSE 87.197 0.997696 1.00579 Axin1 - Axin-1 - Mus musculus (Mouse) - Axin1 gene Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. Taurus_UMD|evm.model.AC_000182.1.26 Q2HJJ1 RM28_BOVIN 100.000 0.923913 1.07812 MRPL28 - 39S ribosomal protein L28, mitochondrial precursor - Bos taurus (Bovine) - MRPL28 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, structural constituent of ribosome Taurus_UMD|evm.model.AC_000182.1.27 Q9HCN3 PGAP6_HUMAN 73.671 0.997386 0.992218 PGAP6 - Post-GPI attachment to proteins factor 6 precursor - Homo sapiens (Human) - PGAP6 gene Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401). Taurus_UMD|evm.model.AC_000182.1.28 O00746 NDKM_HUMAN 83.422 0.989362 1.00535 NME4 - Nucleoside diphosphate kinase, mitochondrial precursor - Homo sapiens (Human) - NME4 gene Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663). Taurus_UMD|evm.model.AC_000182.1.29 Q5RBV3 DECR2_PONAB 88.014 0.993151 1 DECR2 - Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] - Pongo abelii (Sumatran orangutan) - DECR2 gene Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. Taurus_UMD|evm.model.AC_000182.1.30 Q8CHD8 RFIP3_MOUSE 75.559 0.818059 0.708691 Rab11fip3 - Rab11 family-interacting protein 3 - Mus musculus (Mouse) - Rab11fip3 gene Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). Also required for the structural integrity of the endosomal recycling compartment during interphase. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Taurus_UMD|evm.model.AC_000182.1.31 O75808 CAN15_HUMAN 84.483 0.938596 1.04972 CAPN15 - Calpain-15 - Homo sapiens (Human) - CAPN15 gene cytoplasm, calcium-dependent cysteine-type endopeptidase activity, proteolysis Taurus_UMD|evm.model.AC_000182.1.32 P0CG21 NHLC4_HUMAN 77.049 0.14491 6.78862 NHLRC4 - NHL-repeat-containing protein 4 - Homo sapiens (Human) - NHLRC4 gene ubiquitin protein ligase activity, protein K48-linked ubiquitination Taurus_UMD|evm.model.AC_000182.1.33 Q9BRB3 PIGQ_HUMAN 85.686 0.851171 0.786842 PIGQ - Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q - Homo sapiens (Human) - PIGQ gene Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Taurus_UMD|evm.model.AC_000182.1.34 Q96S21 RB40C_HUMAN 99.644 0.992908 1.00356 RAB40C - Ras-related protein Rab-40C - Homo sapiens (Human) - RAB40C gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000182.1.35 Q96NZ8 WFKN1_HUMAN 86.570 0.99637 1.00547 WFIKKN1 - WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor - Homo sapiens (Human) - WFIKKN1 gene Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity). Taurus_UMD|evm.model.AC_000182.1.36 Q32KX8 MTL26_BOVIN 100.000 0.990244 1.0049 METTL26 - Methyltransferase-like 26 - Bos taurus (Bovine) - METTL26 gene Taurus_UMD|evm.model.AC_000182.1.37 Q5E9M9 MIRO2_BOVIN 100.000 0.994898 0.951456 RHOT2 - Mitochondrial Rho GTPase 2 - Bos taurus (Bovine) - RHOT2 gene Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). Taurus_UMD|evm.model.AC_000182.1.38 O88779 RHBL1_RAT 99.390 0.480826 2.06707 Rhbdl1 - Rhomboid-related protein 1 - Rattus norvegicus (Rat) - Rhbdl1 gene May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Taurus_UMD|evm.model.AC_000182.1.40 Q9UNE7 CHIP_HUMAN 97.342 0.9375 1.05611 STUB1 - E3 ubiquitin-protein ligase CHIP - Homo sapiens (Human) - STUB1 gene E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Likely mediates polyubiquitination and downregulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (PubMed:29883609). Taurus_UMD|evm.model.AC_000182.1.41 Q96S16 JMJD8_HUMAN 84.146 0.903101 0.977273 JMJD8 - JmjC domain-containing protein 8 precursor - Homo sapiens (Human) - JMJD8 gene Functions as a positive regulator of TNF-induced NF-kappa-B signaling (PubMed:27671354). Regulates angiogenesis and cellular metabolism through interaction with PKM (PubMed:27199445). Taurus_UMD|evm.model.AC_000182.1.42 Q96S15 WDR24_HUMAN 95.949 0.997472 1.00127 WDR24 - GATOR complex protein WDR24 - Homo sapiens (Human) - WDR24 gene As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823). Taurus_UMD|evm.model.AC_000182.1.43 Q8N461 FXL16_HUMAN 94.410 0.995859 1.00835 FBXL16 - F-box/LRR-repeat protein 16 - Homo sapiens (Human) - FBXL16 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000182.1.44 Q0II70 MCRI2_BOVIN 99.355 0.987179 1.00645 MCRIP2 - MAPK regulated corepressor interacting protein 2 - Bos taurus (Bovine) - MCRIP2 gene cytoplasm, cytoplasmic stress granule, nucleus Taurus_UMD|evm.model.AC_000182.1.45 Q96KV7 WDR90_HUMAN 67.547 0.998376 1.05664 WDR90 - WD repeat-containing protein 90 - Homo sapiens (Human) - WDR90 gene Required for efficient primary cilium formation. Taurus_UMD|evm.model.AC_000182.1.46 Q9UJH8 METRN_HUMAN 80.952 0.931507 0.996587 METRN - Meteorin precursor - Homo sapiens (Human) - METRN gene Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity). Taurus_UMD|evm.model.AC_000182.1.47 Q9BQD7 ANKMT_HUMAN 84.979 0.982379 0.965957 ANTKMT - Adenine nucleotide translocase lysine N-methyltransferase - Homo sapiens (Human) - ANTKMT gene Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration (PubMed:31213526). Probably also trimethylates ANT1/SLC25A4 (PubMed:31213526). Taurus_UMD|evm.model.AC_000182.1.48 A2IDD5 CCD78_HUMAN 56.793 0.82448 0.988584 CCDC78 - Coiled-coil domain-containing protein 78 - Homo sapiens (Human) - CCDC78 gene Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome. Taurus_UMD|evm.model.AC_000182.1.49 Q0VBY3 HAGHL_BOVIN 95.745 0.492958 1.4715 HAGHL - Hydroxyacylglutathione hydrolase-like protein - Bos taurus (Bovine) - HAGHL gene Hydrolase acting on ester bonds. Taurus_UMD|evm.model.AC_000182.1.50 A4FV58 CIAO3_BOVIN 100.000 0.995807 1.0021 CIAO3 - Cytosolic iron-sulfur assembly component 3 - Bos taurus (Bovine) - CIAO3 gene Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity). Taurus_UMD|evm.model.AC_000182.1.51 Q13421 MSLN_HUMAN 61.628 0.829208 0.64127 MSLN - Mesothelin precursor - Homo sapiens (Human) - MSLN gene Membrane-anchored forms may play a role in cellular adhesion. Taurus_UMD|evm.model.AC_000182.1.52 Q8C160 MSLNL_MOUSE 67.143 0.758495 1.20292 Mslnl - Mesothelin-like protein precursor - Mus musculus (Mouse) - Mslnl gene May play a role in cellular adhesion. Taurus_UMD|evm.model.AC_000182.1.53 Q17QT4 RUSD1_BOVIN 100.000 0.993528 1.00325 RPUSD1 - RNA pseudouridylate synthase domain-containing protein 1 - Bos taurus (Bovine) - RPUSD1 gene pseudouridine synthase activity, enzyme-directed rRNA pseudouridine synthesis Taurus_UMD|evm.model.AC_000182.1.54 Q8WVB6 CTF18_HUMAN 77.033 0.997957 1.0041 CHTF18 - Chromosome transmission fidelity protein 18 homolog - Homo sapiens (Human) - CHTF18 gene Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374). Taurus_UMD|evm.model.AC_000182.1.55 Q9JMF3 GBG13_MOUSE 95.522 0.970588 1.01493 Gng13 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 precursor - Mus musculus (Mouse) - Gng13 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Taurus_UMD|evm.model.AC_000182.1.57 Q0P5C0 LMF1_BOVIN 98.413 0.984348 1.02496 LMF1 - Lipase maturation factor 1 - Bos taurus (Bovine) - LMF1 gene Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL (By similarity). Taurus_UMD|evm.model.AC_000182.1.59 Q04886 SOX8_MOUSE 88.865 0.861682 1.15302 Sox8 - Transcription factor SOX-8 - Mus musculus (Mouse) - Sox8 gene Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. Taurus_UMD|evm.model.AC_000182.1.60 F1MV99 SSR5_BOVIN 100.000 0.99458 1.00272 SSTR5 - Somatostatin receptor type 5 - Bos taurus (Bovine) - SSTR5 gene Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization (By similarity). Taurus_UMD|evm.model.AC_000182.1.61 P60827 C1QT8_HUMAN 82.305 0.940476 1 C1QTNF8 - Complement C1q tumor necrosis factor-related protein 8 precursor - Homo sapiens (Human) - C1QTNF8 gene May play a role as ligand of RXFP1. Taurus_UMD|evm.model.AC_000182.1.62 Q2TA38 TEKT4_BOVIN 100.000 0.995536 1.00224 TEKT4 - Tektin-4 - Bos taurus (Bovine) - TEKT4 gene May be a structural component of the sperm flagellum. Contributes to normal sperm motility. Taurus_UMD|evm.model.AC_000182.1.65 Q9EQ60 CAC1H_RAT 80.889 0.999102 0.94362 Cacna1h - Voltage-dependent T-type calcium channel subunit alpha-1H - Rattus norvegicus (Rat) - Cacna1h gene Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:11073957). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (By similarity). Taurus_UMD|evm.model.AC_000182.1.66 Q9XSM2 TRYT_SHEEP 83.922 0.933824 0.996337 Tryptase-2 precursor - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000182.1.67 Q9XSM2 TRYT_SHEEP 87.451 0.849498 1.09524 Tryptase-2 precursor - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000182.1.69 P19236 TRYM_CANLF 61.314 0.543825 1.79286 Mastin precursor - Canis lupus familiaris (Dog) Taurus_UMD|evm.model.AC_000182.1.70 Q28CQ4 UBC9_XENTR 100.000 0.987421 1.00633 ube2i - SUMO-conjugating enzyme UBC9 - Xenopus tropicalis (Western clawed frog) - ube2i gene Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation. Taurus_UMD|evm.model.AC_000182.1.71 O94812 BAIP3_HUMAN 89.062 0.998265 0.971356 BAIAP3 - BAI1-associated protein 3 - Homo sapiens (Human) - BAIAP3 gene Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (PubMed:28626000). Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (By similarity). Taurus_UMD|evm.model.AC_000182.1.72 Q9UJK0 TSR3_HUMAN 82.857 0.993671 1.01282 TSR3 - 18S rRNA aminocarboxypropyltransferase - Homo sapiens (Human) - TSR3 gene Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA (Probable). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (Probable). Taurus_UMD|evm.model.AC_000182.1.73 Q58CS8 GNPTG_BOVIN 100.000 0.993485 1.00327 GNPTG - N-acetylglucosamine-1-phosphotransferase subunit gamma precursor - Bos taurus (Bovine) - GNPTG gene Non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors (By similarity). Taurus_UMD|evm.model.AC_000182.1.74 Q5FWH2 UNKL_MOUSE 83.220 0.997271 1.00825 Unkl - Putative E3 ubiquitin-protein ligase UNKL - Mus musculus (Mouse) - Unkl gene May participate in a protein complex showing an E3 ligase activity regulated by Rac1. Ubiquitination is directed towards itself and possibly other substrates, such as Baf60b/Smarcd2. Intrinsic E3 ligase activity has not been proven. Taurus_UMD|evm.model.AC_000182.1.75 Q1ECT8 CSMT1_BOVIN 100.000 0.985294 1.00741 CCSMST1 - Protein CCSMST1 precursor - Bos taurus (Bovine) - CCSMST1 gene Taurus_UMD|evm.model.AC_000182.1.76 A0A1W2PR82 PERC1_HUMAN 64.338 0.766764 1.28464 PERCC1 - Protein PERCC1 - Homo sapiens (Human) - PERCC1 gene Plays a critical role in intestinal function (PubMed:31217582). Acts by promoting the development of enteroendocrine cells (EECs) of the gastrointestinal tract and pancreas (By similarity). It is thereby required for normal enteroendocrine peptide hormone secretion (By similarity). Taurus_UMD|evm.model.AC_000182.1.77 A6NI56 CC154_HUMAN 67.311 0.992593 1.01199 CCDC154 - Coiled-coil domain-containing protein 154 - Homo sapiens (Human) - CCDC154 gene Taurus_UMD|evm.model.AC_000182.1.78 Q4PKH3 CLCN7_BOVIN 100.000 0.997531 1.00124 CLCN7 - H(+)/Cl(-) exchange transporter 7 - Bos taurus (Bovine) - CLCN7 gene Slowly voltage-gated channel mediating the exchange of chloride ions against protons (By similarity). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). Taurus_UMD|evm.model.AC_000182.1.79 Q96A99 PTX4_HUMAN 65.979 0.995736 0.981172 PTX4 - Pentraxin-4 precursor - Homo sapiens (Human) - PTX4 gene Taurus_UMD|evm.model.AC_000182.1.80 A5A6H4 ROA1_PANTR 95.833 0.983471 0.378125 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Pan troglodytes (Chimpanzee) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. Taurus_UMD|evm.model.AC_000182.1.81 P09651 ROA1_HUMAN 100.000 0.371429 0.376344 HNRNPA1 - Heterogeneous nuclear ribonucleoprotein A1 - Homo sapiens (Human) - HNRNPA1 gene Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). Taurus_UMD|evm.model.AC_000182.1.82 Q9Y4R8 TELO2_HUMAN 76.105 0.997579 0.986858 TELO2 - Telomere length regulation protein TEL2 homolog - Homo sapiens (Human) - TELO2 gene Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. Taurus_UMD|evm.model.AC_000182.1.83 E9PY46 IF140_MOUSE 80.276 0.989026 0.995902 Ift140 - Intraflagellar transport protein 140 homolog - Mus musculus (Mouse) - Ift140 gene Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs) (By similarity). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance (PubMed:22282595). Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (PubMed:24619649). Taurus_UMD|evm.model.AC_000182.1.85 Q96RY5 CRML_HUMAN 84.338 0.970274 1.03388 CRAMP1 - Protein cramped-like - Homo sapiens (Human) - CRAMP1 gene nucleus, chromatin binding, pattern specification process Taurus_UMD|evm.model.AC_000182.1.86 Q9H910 JUPI2_HUMAN 75.789 0.989071 0.963158 JPT2 - Jupiter microtubule associated homolog 2 - Homo sapiens (Human) - JPT2 gene cytosol, plasma membrane Taurus_UMD|evm.model.AC_000182.1.87 Q9UPT6 JIP3_HUMAN 93.189 0.998495 0.99476 MAPK8IP3 - C-Jun-amino-terminal kinase-interacting protein 3 - Homo sapiens (Human) - MAPK8IP3 gene The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). Taurus_UMD|evm.model.AC_000182.1.88 Q13232 NDK3_HUMAN 94.675 0.988235 1.00592 NME3 - Nucleoside diphosphate kinase 3 - Homo sapiens (Human) - NME3 gene Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis. Taurus_UMD|evm.model.AC_000182.1.89 P82929 RT34_BOVIN 99.541 0.990868 1.00459 MRPS34 - 28S ribosomal protein S34, mitochondrial - Bos taurus (Bovine) - MRPS34 gene Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation. Taurus_UMD|evm.model.AC_000182.1.90 A4GXA9 EME2_HUMAN 73.879 0.994638 0.984169 EME2 - Probable crossover junction endonuclease EME2 - Homo sapiens (Human) - EME2 gene Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. Taurus_UMD|evm.model.AC_000182.1.91 Q3MHZ2 SPSB3_BOVIN 100.000 0.99422 1.0029 SPSB3 - SPRY domain-containing SOCS box protein 3 - Bos taurus (Bovine) - SPSB3 gene May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000182.1.92 Q3MHY6 NUBP2_BOVIN 100.000 0.992647 1.00369 NUBP2 - Cytosolic Fe-S cluster assembly factor NUBP2 - Bos taurus (Bovine) - NUBP2 gene Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure. Taurus_UMD|evm.model.AC_000182.1.93 P35858 ALS_HUMAN 76.142 0.964052 1.01157 IGFALS - Insulin-like growth factor-binding protein complex acid labile subunit precursor - Homo sapiens (Human) - IGFALS gene Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion. Taurus_UMD|evm.model.AC_000182.1.94 Q3B7M2 GLO2_BOVIN 100.000 0.993528 1.00325 HAGH - Hydroxyacylglutathione hydrolase, mitochondrial precursor - Bos taurus (Bovine) - HAGH gene Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. Taurus_UMD|evm.model.AC_000182.1.95 Q2HJ98 FAHD1_BOVIN 100.000 0.990991 1.00452 FAHD1 - Acylpyruvase FAHD1, mitochondrial precursor - Bos taurus (Bovine) - FAHD1 gene Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro. Also has oxaloacetate decarboxylase activity. Taurus_UMD|evm.model.AC_000182.1.96 Q4R8G6 MEIOB_MACFA 87.126 0.906054 1.01699 MEIOB - Meiosis-specific with OB domain-containing protein - Macaca fascicularis (Crab-eating macaque) - MEIOB gene Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro. Taurus_UMD|evm.model.AC_000182.1.97 Q5GFD5 HS3S6_MOUSE 90.093 0.938776 1.00292 Hs3st6 - Heparan sulfate glucosamine 3-O-sulfotransferase 6 - Mus musculus (Mouse) - Hs3st6 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. Taurus_UMD|evm.model.AC_000182.1.98 Q3MHL9 MSRB1_BOVIN 100.000 0.978947 0.818966 MSRB1 - Methionine-R-sulfoxide reductase B1 - Bos taurus (Bovine) - MSRB1 gene Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages. Taurus_UMD|evm.model.AC_000182.1.99 Q3SZ10 RL3L_BOVIN 100.000 0.856237 1.16216 RPL3L - 60S ribosomal protein L3-like - Bos taurus (Bovine) - RPL3L gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome, ribosomal large subunit assembly Taurus_UMD|evm.model.AC_000182.1.100 Q02373 NDUBA_BOVIN 100.000 0.988701 1.00568 NDUFB10 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 - Bos taurus (Bovine) - NDUFB10 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000182.1.101 O18789 RS2_BOVIN 100.000 0.993197 1.00341 RPS2 - 40S ribosomal protein S2 - Bos taurus (Bovine) - RPS2 gene cytosolic small ribosomal subunit, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000182.1.102 Q2TBT8 RN151_BOVIN 100.000 0.919231 1.08333 RNF151 - RING finger protein 151 - Bos taurus (Bovine) - RNF151 gene ubiquitin protein ligase activity, protein ubiquitination Taurus_UMD|evm.model.AC_000182.1.103 Q2KJJ5 TBL3_BOVIN 99.750 0.981572 1.0175 TBL3 - Transducin beta-like protein 3 - Bos taurus (Bovine) - TBL3 gene 90S preribosome, nucleolus, U3 snoRNA binding, endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000182.1.104 Q8NFA2 NOXO1_HUMAN 68.466 0.969188 0.949468 NOXO1 - NADPH oxidase organizer 1 - Homo sapiens (Human) - NOXO1 gene Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. Taurus_UMD|evm.model.AC_000182.1.105 P55789 ALR_HUMAN 83.981 0.577904 1.72195 GFER - FAD-linked sulfhydryl oxidase ALR - Homo sapiens (Human) - GFER gene FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Taurus_UMD|evm.model.AC_000182.1.106 A2VE58 SNG3_BOVIN 100.000 0.991304 1.00437 SYNGR3 - Synaptogyrin-3 - Bos taurus (Bovine) - SYNGR3 gene May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal. Taurus_UMD|evm.model.AC_000182.1.107 Q86UK7 ZN598_HUMAN 80.930 0.875789 1.05088 ZNF598 - E3 ubiquitin-protein ligase ZNF598 - Homo sapiens (Human) - ZNF598 gene E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation (PubMed:28065601, PubMed:28132843). Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3 (PubMed:28065601, PubMed:28132843). Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843). Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931). Taurus_UMD|evm.model.AC_000182.1.108 Q8N729 NPW_HUMAN 66.364 0.356436 1.83636 NPW - Neuropeptide W precursor - Homo sapiens (Human) - NPW gene Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30. Taurus_UMD|evm.model.AC_000182.1.109 Q15599 NHRF2_HUMAN 94.065 0.994083 1.00297 SLC9A3R2 - Na(+)/H(+) exchange regulatory cofactor NHE-RF2 - Homo sapiens (Human) - SLC9A3R2 gene Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. Taurus_UMD|evm.model.AC_000182.1.110 Q2KID2 NTH_BOVIN 100.000 0.846645 1.02623 NTHL1 - Endonuclease III-like protein 1 precursor - Bos taurus (Bovine) - NTHL1 gene Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Taurus_UMD|evm.model.AC_000182.1.111 P49815 TSC2_HUMAN 90.066 0.947452 1.04261 TSC2 - Tuberin - Homo sapiens (Human) - TSC2 gene In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). Taurus_UMD|evm.model.AC_000182.1.112 P98161 PKD1_HUMAN 80.365 0.991608 0.996979 PKD1 - Polycystin-1 precursor - Homo sapiens (Human) - PKD1 gene Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Both PKD1 and PKD2 are required for channel activity (PubMed:27214281). Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. Taurus_UMD|evm.model.AC_000182.1.113 Q29RR0 RAB26_BOVIN 100.000 0.992218 1.00391 RAB26 - Ras-related protein Rab-26 - Bos taurus (Bovine) - RAB26 gene Participates in exocrine secretion: regulates the secretion of acinar granules in the parotid gland. Taurus_UMD|evm.model.AC_000182.1.114 Q922B6 TRAF7_MOUSE 98.653 0.885075 1.12795 Traf7 - E3 ubiquitin-protein ligase TRAF7 - Mus musculus (Mouse) - Traf7 gene E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Taurus_UMD|evm.model.AC_000182.1.115 Q8WXD9 CSKI1_HUMAN 89.614 0.986111 1.00629 CASKIN1 - Caskin-1 - Homo sapiens (Human) - CASKIN1 gene May link the scaffolding protein CASK to downstream intracellular effectors. Taurus_UMD|evm.model.AC_000182.1.116 Q17QU5 LST8_BOVIN 100.000 0.993884 1.00307 MLST8 - Target of rapamycin complex subunit LST8 - Bos taurus (Bovine) - MLST8 gene Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657' (By similarity). Taurus_UMD|evm.model.AC_000182.1.117 Q6PL45 BRID5_HUMAN 65.049 0.808411 0.823077 BRICD5 - BRICHOS domain-containing protein 5 - Homo sapiens (Human) - BRICD5 gene extracellular space, regulation of cell population proliferation Taurus_UMD|evm.model.AC_000182.1.118 Q2T9S4 PGP_BOVIN 100.000 0.993789 1.00312 PGP - Glycerol-3-phosphate phosphatase - Bos taurus (Bovine) - PGP gene Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP. Taurus_UMD|evm.model.AC_000182.1.119 Q66K89 E4F1_HUMAN 88.662 0.997446 0.998724 E4F1 - Transcription factor E4F1 - Homo sapiens (Human) - E4F1 gene May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription. Taurus_UMD|evm.model.AC_000182.1.120 Q9D1G0 DNSL2_MOUSE 82.014 0.992832 1.0036 Dnase1l2 - Deoxyribonuclease-1-like 2 precursor - Mus musculus (Mouse) - Dnase1l2 gene Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells (By similarity). Taurus_UMD|evm.model.AC_000182.1.121 P42126 ECI1_HUMAN 77.558 0.993421 1.00662 ECI1 - Enoyl-CoA delta isomerase 1, mitochondrial precursor - Homo sapiens (Human) - ECI1 gene Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Taurus_UMD|evm.model.AC_000182.1.122 Q99758 ABCA3_HUMAN 89.137 0.856999 1.16549 ABCA3 - Phospholipid-transporting ATPase ABCA3 - Homo sapiens (Human) - ABCA3 gene Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:16959783, PubMed:17574245, PubMed:28887056, PubMed:31473345, PubMed:27177387). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:27177387). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (PubMed:26903515, PubMed:25817392, PubMed:27177387). Taurus_UMD|evm.model.AC_000182.1.124 E9PU17 ABCAH_RAT 65.822 0.952756 1.00282 Abca17 - ATP-binding cassette sub-family A member 17 - Rattus norvegicus (Rat) - Abca17 gene Promotes cholesterol efflux from sperm which renders sperm capable of fertilization. Has also been shown to decrease levels of intracellular esterified neutral lipids including cholesteryl esters, fatty acid esters and triacylglycerols. Taurus_UMD|evm.model.AC_000182.1.125 A5PK16 CCNF_BOVIN 100.000 0.647204 1.54315 CCNF - Cyclin-F - Bos taurus (Bovine) - CCNF gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. Taurus_UMD|evm.model.AC_000182.1.126 Q9NV29 TM100_HUMAN 38.554 0.752294 0.813433 TMEM100 - Transmembrane protein 100 - Homo sapiens (Human) - TMEM100 gene Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. Taurus_UMD|evm.model.AC_000182.1.127 O00634 NET3_HUMAN 91.459 0.965577 1.00172 NTN3 - Netrin-3 precursor - Homo sapiens (Human) - NTN3 gene Netrins control guidance of CNS commissural axons and peripheral motor axons. Taurus_UMD|evm.model.AC_000182.1.128 Q29RJ2 TBC24_BOVIN 98.246 0.913357 1.07364 TBC1D24 - TBC1 domain family member 24 - Bos taurus (Bovine) - TBC1D24 gene May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. Involved in the regulation of synaptic vesicle trafficking. Taurus_UMD|evm.model.AC_000182.1.129 P23956 VATL_BOVIN 100.000 0.987179 1.00645 ATP6V0C - V-type proton ATPase 16 kDa proteolipid subunit - Bos taurus (Bovine) - ATP6V0C gene Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Taurus_UMD|evm.model.AC_000182.1.130 A7MBC0 NAGA_BOVIN 100.000 0.995122 1.00244 AMDHD2 - N-acetylglucosamine-6-phosphate deacetylase - Bos taurus (Bovine) - AMDHD2 gene Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Taurus_UMD|evm.model.AC_000182.1.131 O15530 PDPK1_HUMAN 95.811 0.840491 1.17266 PDPK1 - 3-phosphoinositide-dependent protein kinase 1 - Homo sapiens (Human) - PDPK1 gene Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive. Taurus_UMD|evm.model.AC_000182.1.133 A5PKG7 KCTD5_BOVIN 100.000 0.991489 1.00427 KCTD5 - BTB/POZ domain-containing protein KCTD5 - Bos taurus (Bovine) - KCTD5 gene Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (By similarity). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (By similarity). Taurus_UMD|evm.model.AC_000182.1.134 Q9BQR3 PRS27_HUMAN 82.156 0.858974 1.07586 PRSS27 - Serine protease 27 precursor - Homo sapiens (Human) - PRSS27 gene Taurus_UMD|evm.model.AC_000182.1.135 Q9GZN4 BSSP4_HUMAN 79.139 0.923313 1.02839 PRSS22 - Brain-specific serine protease 4 precursor - Homo sapiens (Human) - PRSS22 gene Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA. Taurus_UMD|evm.model.AC_000182.1.136 Q96DA0 ZG16B_HUMAN 51.799 0.884615 0.75 ZG16B - Zymogen granule protein 16 homolog B precursor - Homo sapiens (Human) - ZG16B gene extracellular exosome, extracellular space, retina homeostasis Taurus_UMD|evm.model.AC_000182.1.137 Q96DA0 ZG16B_HUMAN 52.899 0.867089 0.759615 ZG16B - Zymogen granule protein 16 homolog B precursor - Homo sapiens (Human) - ZG16B gene extracellular exosome, extracellular space, retina homeostasis Taurus_UMD|evm.model.AC_000182.1.138 P0DP42 T225B_HUMAN 71.875 0.969543 0.891403 TMEM225B - Transmembrane protein 225B - Homo sapiens (Human) - TMEM225B gene Taurus_UMD|evm.model.AC_000182.1.139 Q9Y6M0 TEST_HUMAN 65.979 0.888545 1.02866 PRSS21 - Testisin precursor - Homo sapiens (Human) - PRSS21 gene Could regulate proteolytic events associated with testicular germ cell maturation. Taurus_UMD|evm.model.AC_000182.1.140 Q7RTY9 PRS41_HUMAN 58.238 0.796923 1.02201 PRSS41 - Serine protease 41 precursor - Homo sapiens (Human) - PRSS41 gene extracellular region, intracellular organelle, plasma membrane, sodium channel regulator activity Taurus_UMD|evm.model.AC_000182.1.141 Q8NF86 PRS33_HUMAN 82.174 0.828467 0.978571 PRSS33 - Serine protease 33 precursor - Homo sapiens (Human) - PRSS33 gene Serine protease that has amidolytic activity, cleaving its substrates before Arg residues. Taurus_UMD|evm.model.AC_000182.1.142 Q15370 ELOB_HUMAN 97.458 0.983193 1.00847 ELOB - Elongin-B - Homo sapiens (Human) - ELOB gene SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). Taurus_UMD|evm.model.AC_000182.1.143 Q9UQ35 SRRM2_HUMAN 83.997 0.434719 0.996366 SRRM2 - Serine/arginine repetitive matrix protein 2 - Homo sapiens (Human) - SRRM2 gene Required for pre-mRNA splicing as component of the spliceosome. Taurus_UMD|evm.model.AC_000182.1.144 Q9CQE9 FWCH2_MOUSE 84.746 0.793103 1.04317 Flywch2 - FLYWCH family member 2 - Mus musculus (Mouse) - Flywch2 gene Taurus_UMD|evm.model.AC_000182.1.146 Q4VC44 FWCH1_HUMAN 77.040 0.997211 1.0014 FLYWCH1 - FLYWCH-type zinc finger-containing protein 1 - Homo sapiens (Human) - FLYWCH1 gene cytosol, nuclear body, nucleoplasm Taurus_UMD|evm.model.AC_000182.1.147 Q8K1S7 KREM2_MOUSE 97.927 0.443418 0.939262 Kremen2 - Kremen protein 2 precursor - Mus musculus (Mouse) - Kremen2 gene Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6 (PubMed:12050670). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation (PubMed:18505822). Taurus_UMD|evm.model.AC_000182.1.148 Q8N4S7 PAQR4_HUMAN 94.139 0.992701 1.00366 PAQR4 - Progestin and adipoQ receptor family member 4 - Homo sapiens (Human) - PAQR4 gene signaling receptor activity Taurus_UMD|evm.model.AC_000182.1.149 Q99640 PMYT1_HUMAN 89.336 0.995984 0.997996 PKMYT1 - Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase - Homo sapiens (Human) - PKMYT1 gene Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. Taurus_UMD|evm.model.AC_000182.1.151 O95484 CLD9_HUMAN 96.313 0.990826 1.00461 CLDN9 - Claudin-9 - Homo sapiens (Human) - CLDN9 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Taurus_UMD|evm.model.AC_000182.1.152 P56747 CLD6_HUMAN 90.950 0.990991 1.00909 CLDN6 - Claudin-6 - Homo sapiens (Human) - CLDN6 gene Plays a major role in tight junction-specific obliteration of the intercellular space. Taurus_UMD|evm.model.AC_000182.1.153 Q9NP84 TNR12_HUMAN 88.785 0.815385 1.00775 TNFRSF12A - Tumor necrosis factor receptor superfamily member 12A precursor - Homo sapiens (Human) - TNFRSF12A gene Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Taurus_UMD|evm.model.AC_000182.1.154 Q9NWW0 HPIP_HUMAN 88.406 0.985612 1.00725 HCFC1R1 - Host cell factor C1 regulator 1 - Homo sapiens (Human) - HCFC1R1 gene Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus. Taurus_UMD|evm.model.AC_000182.1.155 Q86W42 THOC6_HUMAN 95.894 0.994152 1.00293 THOC6 - THO complex subunit 6 homolog - Homo sapiens (Human) - THOC6 gene Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development. Taurus_UMD|evm.model.AC_000182.1.156 A1A5D9 BICL2_HUMAN 85.265 0.996055 0.998031 BICDL2 - BICD family-like cargo adapter 2 - Homo sapiens (Human) - BICDL2 gene Golgi to secretory granule transport, vesicle transport along microtubule Taurus_UMD|evm.model.AC_000182.1.157 Q9NPA2 MMP25_HUMAN 85.158 0.960644 0.994662 MMP25 - Matrix metalloproteinase-25 precursor - Homo sapiens (Human) - MMP25 gene May activate progelatinase A. Taurus_UMD|evm.model.AC_000182.1.158 P24001 IL32_HUMAN 28.105 0.866279 0.735043 IL32 - Interleukin-32 precursor - Homo sapiens (Human) - IL32 gene Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. Taurus_UMD|evm.model.AC_000182.1.159 Q9NPA2 MMP25_HUMAN 78.723 0.22549 0.362989 MMP25 - Matrix metalloproteinase-25 precursor - Homo sapiens (Human) - MMP25 gene May activate progelatinase A. Taurus_UMD|evm.model.AC_000182.1.160 P24001 IL32_HUMAN 28.105 0.866279 0.735043 IL32 - Interleukin-32 precursor - Homo sapiens (Human) - IL32 gene Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. Taurus_UMD|evm.model.AC_000182.1.161 Q9NPA2 MMP25_HUMAN 80.000 0.168831 0.411032 MMP25 - Matrix metalloproteinase-25 precursor - Homo sapiens (Human) - MMP25 gene May activate progelatinase A. Taurus_UMD|evm.model.AC_000182.1.162 Q96SZ4 ZSC10_HUMAN 79.070 0.926302 1.08552 ZSCAN10 - Zinc finger and SCAN domain-containing protein 10 - Homo sapiens (Human) - ZSCAN10 gene Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4. Taurus_UMD|evm.model.AC_000182.1.163 Q58DK7 ZN205_BOVIN 99.636 0.99637 1.00182 ZNF205 - Zinc finger protein 205 - Bos taurus (Bovine) - ZNF205 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.164 O14771 ZN213_HUMAN 82.135 0.995624 0.995643 ZNF213 - Zinc finger protein 213 - Homo sapiens (Human) - ZNF213 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.165 P31944 CASPE_HUMAN 40.299 0.56051 1.94628 CASP14 - Caspase-14 precursor - Homo sapiens (Human) - CASP14 gene Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736). Taurus_UMD|evm.model.AC_000182.1.166 P98182 ZN200_HUMAN 86.076 0.994924 0.997468 ZNF200 - Zinc finger protein 200 - Homo sapiens (Human) - ZNF200 gene Could have a role in spermatogenesis. Taurus_UMD|evm.model.AC_000182.1.167 O15553 MEFV_HUMAN 55.066 0.997059 0.870679 MEFV - Pyrin - Homo sapiens (Human) - MEFV gene Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (PubMed:16037825, PubMed:27030597, PubMed:28835462). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). Taurus_UMD|evm.model.AC_000182.1.168 O14978 ZN263_HUMAN 89.197 0.997085 1.00439 ZNF263 - Zinc finger protein 263 - Homo sapiens (Human) - ZNF263 gene Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553). Acts as transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030). Taurus_UMD|evm.model.AC_000182.1.169 Q6NT04 TIGD7_HUMAN 91.268 0.967213 0.666667 TIGD7 - Tigger transposable element-derived protein 7 - Homo sapiens (Human) - TIGD7 gene nucleus, DNA binding Taurus_UMD|evm.model.AC_000182.1.170 Q5R4A5 SNX17_PONAB 86.170 0.14876 1.28723 SNX17 - Sorting nexin-17 - Pongo abelii (Sumatran orangutan) - SNX17 gene Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). Taurus_UMD|evm.model.AC_000182.1.171 Q5EA77 SNX17_BOVIN 66.667 0.978723 0.2 SNX17 - Sorting nexin-17 - Bos taurus (Bovine) - SNX17 gene Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). Taurus_UMD|evm.model.AC_000182.1.172 Q96N20 ZN75A_HUMAN 81.343 0.698163 1.28716 ZNF75A - Zinc finger protein 75A - Homo sapiens (Human) - ZNF75A gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.173 Q15697 ZN174_HUMAN 83.659 0.995086 1 ZNF174 - Zinc finger protein 174 - Homo sapiens (Human) - ZNF174 gene Transcriptional repressor. Taurus_UMD|evm.model.AC_000182.1.174 Q96LX8 ZN597_HUMAN 60.764 0.686131 0.96934 ZNF597 - Zinc finger protein 597 - Homo sapiens (Human) - ZNF597 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.175 Q17QK9 NAA60_BOVIN 100.000 0.427928 1.83471 NAA60 - N-alpha-acetyltransferase 60 - Bos taurus (Bovine) - NAA60 gene N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences. Taurus_UMD|evm.model.AC_000182.1.176 Q6AYJ5 CLUA1_RAT 85.748 0.970387 1.09204 Cluap1 - Clusterin-associated protein 1 - Rattus norvegicus (Rat) - Cluap1 gene Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. Taurus_UMD|evm.model.AC_000182.1.177 Q7RTR2 NLRC3_HUMAN 85.258 0.998124 1.00094 NLRC3 - NLR family CARD domain-containing protein 3 - Homo sapiens (Human) - NLRC3 gene Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed:25277106). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed:25277106). Taurus_UMD|evm.model.AC_000182.1.178 Q8IY92 SLX4_HUMAN 59.989 0.945464 1.00981 SLX4 - Structure-specific endonuclease subunit SLX4 - Homo sapiens (Human) - SLX4 gene Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. Taurus_UMD|evm.model.AC_000182.1.179 P00639 DNAS1_BOVIN 100.000 0.7025 1.41844 DNASE1 - Deoxyribonuclease-1 precursor - Bos taurus (Bovine) - DNASE1 gene Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:4976790, PubMed:5166750, PubMed:3352748, PubMed:2395459). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:2395459). Binds specifically to G-actin and blocks actin polymerization (PubMed:2395459). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). Taurus_UMD|evm.model.AC_000182.1.180 Q2TBI4 TRAP1_BOVIN 99.858 0.997155 1 TRAP1 - Heat shock protein 75 kDa, mitochondrial precursor - Bos taurus (Bovine) - TRAP1 gene Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. Taurus_UMD|evm.model.AC_000182.1.181 Q92793 CBP_HUMAN 94.438 0.970494 1.02703 CREBBP - CREB-binding protein - Homo sapiens (Human) - CREBBP gene Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). Taurus_UMD|evm.model.AC_000182.1.182 O60503 ADCY9_HUMAN 91.346 0.997048 1.00148 ADCY9 - Adenylate cyclase type 9 - Homo sapiens (Human) - ADCY9 gene Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). Taurus_UMD|evm.model.AC_000182.1.183 Q3T0D6 LEG4_BOVIN 83.133 0.993056 0.86747 LGALS4 - Galectin-4 - Bos taurus (Bovine) - LGALS4 gene Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions (By similarity). Taurus_UMD|evm.model.AC_000182.1.184 P13666 SRCA_RABIT 96.923 0.573232 1.67797 SRL - Sarcalumenin precursor - Oryctolagus cuniculus (Rabbit) - SRL gene Taurus_UMD|evm.model.AC_000182.1.185 Q01664 TFAP4_HUMAN 94.970 0.994048 0.994083 TFAP4 - Transcription factor AP-4 - Homo sapiens (Human) - TFAP4 gene Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'. Taurus_UMD|evm.model.AC_000182.1.186 Q9BZE0 GLIS2_HUMAN 94.847 0.99619 1.00191 GLIS2 - Zinc finger protein GLIS2 - Homo sapiens (Human) - GLIS2 gene Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). Taurus_UMD|evm.model.AC_000182.1.187 Q0V8F1 CORO7_BOVIN 99.131 0.879541 1.14317 CORO7 - Coronin-7 - Bos taurus (Bovine) - CORO7 gene F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity). Taurus_UMD|evm.model.AC_000182.1.188 Q96EY1 DNJA3_HUMAN 90.000 0.995842 1.00208 DNAJA3 - DnaJ homolog subfamily A member 3, mitochondrial precursor - Homo sapiens (Human) - DNAJA3 gene Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. Taurus_UMD|evm.model.AC_000182.1.189 Q0VCN1 NMRL1_BOVIN 100.000 0.993333 1.00334 NMRAL1 - NmrA-like family domain-containing protein 1 - Bos taurus (Bovine) - NMRAL1 gene Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer (By similarity). Taurus_UMD|evm.model.AC_000182.1.190 P30519 HMOX2_HUMAN 80.838 0.883289 1.19304 HMOX2 - Heme oxygenase 2 - Homo sapiens (Human) - HMOX2 gene Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Taurus_UMD|evm.model.AC_000182.1.191 Q58D45 CDIP1_BOVIN 100.000 0.990431 1.00481 CDIP1 - Cell death-inducing p53-target protein 1 - Bos taurus (Bovine) - CDIP1 gene Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner. Taurus_UMD|evm.model.AC_000182.1.194 A6NNT2 CP096_HUMAN 62.621 0.563985 0.958808 C16orf96 - Uncharacterized protein C16orf96 - Homo sapiens (Human) - C16orf96 gene Taurus_UMD|evm.model.AC_000182.1.195 Q8TB05 UBAD1_HUMAN 94.382 0.988827 1.0113 UBALD1 - UBA-like domain-containing protein 1 - Homo sapiens (Human) - UBALD1 gene Taurus_UMD|evm.model.AC_000182.1.196 O60291 MGRN1_HUMAN 87.409 0.935764 1.04348 MGRN1 - E3 ubiquitin-protein ligase MGRN1 - Homo sapiens (Human) - MGRN1 gene E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). Taurus_UMD|evm.model.AC_000182.1.198 Q9BRJ7 TIRR_HUMAN 97.156 0.990566 1.00474 NUDT16L1 - Tudor-interacting repair regulator protein - Homo sapiens (Human) - NUDT16L1 gene Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299). Taurus_UMD|evm.model.AC_000182.1.199 Q5M9H0 ANKS3_RAT 85.197 0.963415 0.989442 Anks3 - Ankyrin repeat and SAM domain-containing protein 3 - Rattus norvegicus (Rat) - Anks3 gene May be involved in vasopressin signaling in the kidney. Taurus_UMD|evm.model.AC_000182.1.200 Q2KIS6 DAAP1_BOVIN 98.058 0.629857 1.35457 DNAAF8 - Dynein axonemal assembly factor 8 - Bos taurus (Bovine) - DNAAF8 gene In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits. Taurus_UMD|evm.model.AC_000182.1.201 O60304 ZN500_HUMAN 67.063 0.960239 1.04792 ZNF500 - Zinc finger protein 500 - Homo sapiens (Human) - ZNF500 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.202 A5D7Q3 SEP12_BOVIN 99.723 0.994475 1.00277 SEPTIN12 - Septin-12 - Bos taurus (Bovine) - SEPTIN12 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins. Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Taurus_UMD|evm.model.AC_000182.1.204 Q148F6 ROGDI_BOVIN 100.000 0.993056 1.00348 ROGDI - Protein rogdi homolog - Bos taurus (Bovine) - ROGDI gene RAVE complex Taurus_UMD|evm.model.AC_000182.1.205 A4FUF0 GLYR1_BOVIN 100.000 0.99639 1.00181 GLYR1 - Putative oxidoreductase GLYR1 - Bos taurus (Bovine) - GLYR1 gene Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Facilitates Pol II transcription through nucleosomes. Binds DNA (in vitro). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Promotes KDM1B demethylase activity. Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Putative oxidoreductase. Taurus_UMD|evm.model.AC_000182.1.207 Q9NPG3 UBN1_HUMAN 85.764 0.998236 1 UBN1 - Ubinuclein-1 - Homo sapiens (Human) - UBN1 gene Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. Taurus_UMD|evm.model.AC_000182.1.208 O60437 PEPL_HUMAN 84.480 0.998861 1 PPL - Periplakin - Homo sapiens (Human) - PPL gene Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. Taurus_UMD|evm.model.AC_000182.1.209 O43304 S14L5_HUMAN 87.073 0.965517 1 SEC14L5 - SEC14-like protein 5 - Homo sapiens (Human) - SEC14L5 gene Taurus_UMD|evm.model.AC_000182.1.210 P68827 NAGPA_BOVIN 89.474 0.996491 1.08159 NAGPA - N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor - Bos taurus (Bovine) - NAGPA gene Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. Taurus_UMD|evm.model.AC_000182.1.211 Q6UX73 CP089_HUMAN 73.101 0.870166 0.900498 C16orf89 - UPF0764 protein C16orf89 precursor - Homo sapiens (Human) - C16orf89 gene cytosol, extracellular exosome, membrane, protein homodimerization activity Taurus_UMD|evm.model.AC_000182.1.212 Q5R7A2 ALG1_PONAB 83.521 0.950538 1.00216 ALG1 - Chitobiosyldiphosphodolichol beta-mannosyltransferase - Pongo abelii (Sumatran orangutan) - ALG1 gene Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER (By similarity). Taurus_UMD|evm.model.AC_000182.1.213 Q1JPJ9 EF2KT_BOVIN 99.412 0.994135 1.00294 EEF2KMT - Protein-lysine N-methyltransferase EEF2KMT - Bos taurus (Bovine) - EEF2KMT gene Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'. Taurus_UMD|evm.model.AC_000182.1.214 Q6UWV6 ENPP7_HUMAN 52.020 0.72 1.0917 ENPP7 - Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 precursor - Homo sapiens (Human) - ENPP7 gene Choline-specific phosphodiesterase that hydrolyzes sphingomyelin releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract (PubMed:12885774, PubMed:12671034, PubMed:15205117, PubMed:16255717, PubMed:28292932). Has also phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation (PubMed:16255717, PubMed:12885774). Does not have nucleotide pyrophosphatase activity (PubMed:12885774). May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (By similarity). Taurus_UMD|evm.model.AC_000182.1.218 Q6PDV7 RL10_RAT 71.429 0.831325 0.38785 Rpl10 - 60S ribosomal protein L10 - Rattus norvegicus (Rat) - Rpl10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000182.1.222 P62752 RL23A_RAT 65.455 0.341772 1.01282 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000182.1.225 Q9NWB1 RFOX1_HUMAN 97.455 0.920188 1.07305 RBFOX1 - RNA binding protein fox-1 homolog 1 - Homo sapiens (Human) - RBFOX1 gene RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Taurus_UMD|evm.model.AC_000182.1.231 B3SHH9 TM114_HUMAN 87.444 0.991071 1.00448 TMEM114 - Transmembrane protein 114 - Homo sapiens (Human) - TMEM114 gene apical plasma membrane Taurus_UMD|evm.model.AC_000182.1.232 Q8R1C6 MET22_MOUSE 78.295 0.954774 1.01272 Mettl22 - Methyltransferase-like protein 22 - Mus musculus (Mouse) - Mettl22 gene Protein N-lysine methyltransferase. In vitro methylates KIN (By similarity). Taurus_UMD|evm.model.AC_000182.1.233 P80147 GABT_PIG 95.600 0.996008 1.002 ABAT - 4-aminobutyrate aminotransferase, mitochondrial precursor - Sus scrofa (Pig) - ABAT gene Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. Taurus_UMD|evm.model.AC_000182.1.234 Q5EA03 TM186_BOVIN 100.000 0.99061 1.00472 TMEM186 - Transmembrane protein 186 - Bos taurus (Bovine) - TMEM186 gene mitochondrion Taurus_UMD|evm.model.AC_000182.1.235 Q3SZJ9 PMM2_BOVIN 100.000 0.991903 1.00407 PMM2 - Phosphomannomutase 2 - Bos taurus (Bovine) - PMM2 gene Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. Taurus_UMD|evm.model.AC_000182.1.236 Q9WU49 CHSP1_RAT 95.238 0.986486 1.0068 Carhsp1 - Calcium-regulated heat stable protein 1 - Rattus norvegicus (Rat) - Carhsp1 gene Binds mRNA and regulates the stability of target mRNA. Taurus_UMD|evm.model.AC_000182.1.237 A0A1B0GVX0 LITAD_HUMAN 67.606 0.47619 2.04167 LITAFD - LITAF domain-containing protein - Homo sapiens (Human) - LITAFD gene Taurus_UMD|evm.model.AC_000182.1.238 Q4VSI4 UBP7_RAT 99.071 0.98988 0.985494 Usp7 - Ubiquitin carboxyl-terminal hydrolase 7 - Rattus norvegicus (Rat) - Usp7 gene Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:16111684, PubMed:16328052). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (By similarity). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (By similarity). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (By similarity). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (By similarity). Deubiquitinates KMT2E preventing KMT2E proteasomal-mediated degradation (By similarity). Involved in cell proliferation during early embryonic development (By similarity). Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (By similarity). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (By similarity). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (By similarity). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (By similarity). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (By similarity). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing transcription factor FOXP3 which is crucial for Treg cell function (By similarity). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (By similarity). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (By similarity). Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis (By similarity). Taurus_UMD|evm.model.AC_000182.1.240 Q14CZ0 CP072_HUMAN 100.000 0.992754 1.00364 C16orf72 - UPF0472 protein C16orf72 - Homo sapiens (Human) - C16orf72 gene Taurus_UMD|evm.model.AC_000182.1.244 P35436 NMDE1_MOUSE 94.863 0.972414 0.79235 Grin2a - Glutamate receptor ionotropic, NMDA 2A precursor - Mus musculus (Mouse) - Grin2a gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium (PubMed:1374164). Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (By similarity). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (PubMed:7816096, PubMed:8987814). Taurus_UMD|evm.model.AC_000182.1.245 P35436 NMDE1_MOUSE 97.015 0.673469 0.0669399 Grin2a - Glutamate receptor ionotropic, NMDA 2A precursor - Mus musculus (Mouse) - Grin2a gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium (PubMed:1374164). Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (By similarity). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (PubMed:7816096, PubMed:8987814). Taurus_UMD|evm.model.AC_000182.1.246 Q00959 NMDE1_RAT 97.101 0.913333 0.102459 Grin2a - Glutamate receptor ionotropic, NMDA 2A precursor - Rattus norvegicus (Rat) - Grin2a gene Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (PubMed:28384476). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Taurus_UMD|evm.model.AC_000182.1.247 Q5U623 MCAF2_HUMAN 69.784 0.997089 1.00733 ATF7IP2 - Activating transcription factor 7-interacting protein 2 - Homo sapiens (Human) - ATF7IP2 gene Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable). Taurus_UMD|evm.model.AC_000182.1.248 Q2NKU9 EMP2_BOVIN 99.401 0.988095 1.00599 EMP2 - Epithelial membrane protein 2 - Bos taurus (Bovine) - EMP2 gene Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and the formation of lipid rafts bearing GPI-anchor proteins. Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity. Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion. Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation. Regulates cell migration and cell contraction through PTK2 and SRC activation. Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2. Positively regulates cell proliferation. Plays a role during cell death and cell blebbing. Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway. Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3. May play a role in glomerular filtration. Taurus_UMD|evm.model.AC_000182.1.249 Q2YDI7 TEKT5_BOVIN 100.000 0.692308 0.717791 TEKT5 - Tektin-5 - Bos taurus (Bovine) - TEKT5 gene May be a structural component of the sperm flagellum. Taurus_UMD|evm.model.AC_000182.1.250 Q24K00 NUBP1_BOVIN 96.250 0.993548 0.96875 NUBP1 - Cytosolic Fe-S cluster assembly factor NUBP1 - Bos taurus (Bovine) - NUBP1 gene Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication. Negatively regulates cilium formation and structure. Taurus_UMD|evm.model.AC_000182.1.251 A6NH52 TV23A_HUMAN 90.094 0.689542 1.43662 TVP23A - Golgi apparatus membrane protein TVP23 homolog A - Homo sapiens (Human) - TVP23A gene integral component of Golgi membrane, protein secretion, vesicle-mediated transport Taurus_UMD|evm.model.AC_000182.1.252 P33076 C2TA_HUMAN 77.135 0.927092 1.06814 CIITA - MHC class II transactivator - Homo sapiens (Human) - CIITA gene Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2. Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215). Taurus_UMD|evm.model.AC_000182.1.253 O95424 DEXI_HUMAN 96.842 0.979167 1.01053 DEXI - Dexamethasone-induced protein - Homo sapiens (Human) - DEXI gene Taurus_UMD|evm.model.AC_000182.1.254 Q2KHT3 CL16A_HUMAN 92.490 0.99714 0.996201 CLEC16A - Protein CLEC16A - Homo sapiens (Human) - CLEC16A gene Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. Taurus_UMD|evm.model.AC_000182.1.258 O15524 SOCS1_HUMAN 91.928 0.991071 1.06161 SOCS1 - Suppressor of cytokine signaling 1 - Homo sapiens (Human) - SOCS1 gene SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through binding to JAKs and IFNGR1, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. Taurus_UMD|evm.model.AC_000182.1.259 P26377 STP2_BOVIN 100.000 0.984962 1.00758 TNP2 - Nuclear transition protein 2 - Bos taurus (Bovine) - TNP2 gene Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Taurus_UMD|evm.model.AC_000182.1.260 Q32PA2 PRM3_BOVIN 100.000 0.978723 1.01075 PRM3 - Protamine-3 - Bos taurus (Bovine) - PRM3 gene Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity). Taurus_UMD|evm.model.AC_000182.1.261 P19782 PRM2_BOVIN 80.870 0.628378 1.28696 PRM2 - Protamine-2 - Bos taurus (Bovine) - PRM2 gene Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. Taurus_UMD|evm.model.AC_000182.1.262 A5PJU7 RMI2_BOVIN 99.363 0.987342 1.00637 RMI2 - RecQ-mediated genome instability protein 2 - Bos taurus (Bovine) - RMI2 gene Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. Taurus_UMD|evm.model.AC_000182.1.263 Q6ZTK2 YP015_HUMAN 73.371 0.142288 6.84909 Putative uncharacterized protein LOC400499 - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000182.1.264 P0C0T0 LITAF_RAT 91.925 0.987654 1.00621 Litaf - Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog - Rattus norvegicus (Rat) - Litaf gene Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines. May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10. Taurus_UMD|evm.model.AC_000182.1.265 Q17Q87 SNN_BOVIN 100.000 0.601399 1.64368 SNN - Stannin - Bos taurus (Bovine) - SNN gene Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation. Taurus_UMD|evm.model.AC_000182.1.266 A4FUW8 TXD11_BOVIN 99.896 0.997912 1.00104 TXNDC11 - Thioredoxin domain-containing protein 11 - Bos taurus (Bovine) - TXNDC11 gene May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation (By similarity). Taurus_UMD|evm.model.AC_000182.1.267 Q8IWR0 Z3H7A_HUMAN 93.930 0.875564 1.14212 ZC3H7A - Zinc finger CCCH domain-containing protein 7A - Homo sapiens (Human) - ZC3H7A gene May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop. Taurus_UMD|evm.model.AC_000182.1.269 A4FV97 RL1D1_BOVIN 100.000 0.995859 1.00207 RSL1D1 - Ribosomal L1 domain-containing protein 1 - Bos taurus (Bovine) - RSL1D1 gene Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. Taurus_UMD|evm.model.AC_000182.1.270 P15170 ERF3A_HUMAN 99.198 0.780564 1.27856 GSPT1 - Eukaryotic peptide chain release factor GTP-binding subunit ERF3A - Homo sapiens (Human) - GSPT1 gene Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activity of ETF1 (By similarity). Involved in regulation of mammalian cell growth (PubMed:2511002). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). Taurus_UMD|evm.model.AC_000182.1.271 Q08DX0 SNX29_BOVIN 96.806 0.875761 1.0049 SNX29 - Sorting nexin-29 - Bos taurus (Bovine) - SNX29 gene Taurus_UMD|evm.model.AC_000182.1.272 Q58DC0 CPPED_BOVIN 99.361 0.993631 1.00319 CPPED1 - Serine/threonine-protein phosphatase CPPED1 - Bos taurus (Bovine) - CPPED1 gene Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes (By similarity). Taurus_UMD|evm.model.AC_000182.1.273 Q9CZN4 SHSA9_MOUSE 91.294 0.904656 1.06368 Shisa9 - Protein shisa-9 precursor - Mus musculus (Mouse) - Shisa9 gene Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses. Taurus_UMD|evm.model.AC_000182.1.276 Q92889 XPF_HUMAN 87.340 0.997875 1.02729 ERCC4 - DNA repair endonuclease XPF - Homo sapiens (Human) - ERCC4 gene Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. Taurus_UMD|evm.model.AC_000182.1.277 Q6AYL5 SF3B4_RAT 82.249 0.613971 0.641509 Sf3b4 - Splicing factor 3B subunit 4 - Rattus norvegicus (Rat) - Sf3b4 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Taurus_UMD|evm.model.AC_000182.1.278 Q9ULH7 MRTFB_HUMAN 85.294 0.952734 0.991728 MRTFB - Myocardin-related transcription factor B - Homo sapiens (Human) - MRTFB gene Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. Taurus_UMD|evm.model.AC_000182.1.279 P69341 PARN_BOVIN 100.000 0.993994 0.521944 PARN - Poly(A)-specific ribonuclease PARN - Bos taurus (Bovine) - PARN gene 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity). Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails (By similarity) (PubMed:10698948, PubMed:9736620). Also able to recognize poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (By similarity). Taurus_UMD|evm.model.AC_000182.1.280 Q9NZS9 BFAR_HUMAN 90.444 0.995565 1.00222 BFAR - Bifunctional apoptosis regulator - Homo sapiens (Human) - BFAR gene Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. Taurus_UMD|evm.model.AC_000182.1.281 O15496 PA2GX_HUMAN 69.173 0.809816 0.987879 PLA2G10 - Group 10 secretory phospholipase A2 precursor - Homo sapiens (Human) - PLA2G10 gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:9188469, PubMed:12021277). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls (PubMed:12359733, PubMed:12021277). Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles (PubMed:12021277). Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (PubMed:12021277). Efficiently hydrolyzes and inactivates platelet activating factor (PAF), a potent lipid mediator present in oxidized LDL (PubMed:16962371). May act in an autocrine and paracrine manner. Secreted by lung epithelium, targets membrane phospholipids of infiltrating eosinophils, releasing arachidonate and boosting eicosanoid and cysteinyl leukotriene synthesis involved in airway inflammatory response (By similarity). Secreted by gut epithelium, hydrolyzes dietary and biliary phosphatidylcholines in the gastrointestinal lumen (By similarity). Plays a stem cell regulator role in colon epithelium. Within intracellular compartment, mediates Paneth-like cell differentiation and its stem cell supporting functions by inhibiting the Wnt signaling pathway in intestinal stem cell (ISC). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ISCs and tissue regeneration (By similarity). May participate in hair follicle morphogenesis by regulating phosphatidylethanolamines metabolism at the outermost epithelial layer and facilitating melanin synthesis (By similarity). By releasing lysophosphatidylcholines (LPCs) at sperm acrosome, controls sperm cell capacitation, acrosome reaction and overall fertility (By similarity). May promote neurite outgrowth in neuron fibers involved in nociception (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria (PubMed:12359733). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). In pulmonary epithelium, may contribute to host defense response against adenoviral infection. Prevents adenovirus entry into host cells by hydrolyzing host cell plasma membrane, releasing C16:0 LPCs that inhibit virus-mediated membrane fusion and viral infection. Likely prevents adenoviral entry into the endosomes of host cells (PubMed:16146426). May play a role in maturation and activation of innate immune cells including macrophages, group 2 innate lymphoid cells and mast cells (By similarity). Taurus_UMD|evm.model.AC_000182.1.282 Q96H20 SNF8_HUMAN 76.119 0.970588 0.263566 SNF8 - Vacuolar-sorting protein SNF8 - Homo sapiens (Human) - SNF8 gene Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Taurus_UMD|evm.model.AC_000182.1.283 C9JI98 TM238_HUMAN 43.299 0.130814 3.90909 TMEM238 - Transmembrane protein 238 - Homo sapiens (Human) - TMEM238 gene Taurus_UMD|evm.model.AC_000182.1.284 O77768 HNRPC_RABIT 83.871 0.884058 0.22549 HNRNPC - Heterogeneous nuclear ribonucleoprotein C - Oryctolagus cuniculus (Rabbit) - HNRNPC gene Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing. Taurus_UMD|evm.model.AC_000182.1.285 Q2M238 RN3P1_HUMAN 93.662 0.216258 4.28947 RRN3P1 - Putative RRN3-like protein RRN3P1 - Homo sapiens (Human) - RRN3P1 gene nucleus, RNA polymerase I core binding, RNA polymerase I general transcription initiation factor activity, transcription initiation from RNA polymerase I promoter Taurus_UMD|evm.model.AC_000182.1.286 Q96AB6 NTAN1_HUMAN 94.194 0.993569 1.00323 NTAN1 - Protein N-terminal asparagine amidohydrolase - Homo sapiens (Human) - NTAN1 gene N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn. Taurus_UMD|evm.model.AC_000182.1.287 A7MBC2 PDXD1_BOVIN 100.000 0.997462 1.00127 PDXDC1 - Pyridoxal-dependent decarboxylase domain-containing protein 1 - Bos taurus (Bovine) - PDXDC1 gene endoplasmic reticulum, sphinganine-1-phosphate aldolase activity, ameboidal-type cell migration, sphingolipid catabolic process Taurus_UMD|evm.model.AC_000182.1.288 Q2KIK2 MP17L_BOVIN 99.490 0.989848 1.0051 MPV17L - Mpv17-like protein - Bos taurus (Bovine) - MPV17L gene Participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes. Taurus_UMD|evm.model.AC_000182.1.289 Q5R562 MERB1_PONAB 96.078 0.990244 1.0049 BMERB1 - bMERB domain-containing protein 1 - Pongo abelii (Sumatran orangutan) - BMERB1 gene Taurus_UMD|evm.model.AC_000182.1.290 E1BP74 MARF1_BOVIN 99.369 0.998269 0.994834 MARF1 - Meiosis regulator and mRNA stability factor 1 - Bos taurus (Bovine) - MARF1 gene Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). Taurus_UMD|evm.model.AC_000182.1.291 Q9NXR1 NDE1_HUMAN 92.429 0.910663 1.03582 NDE1 - Nuclear distribution protein nudE homolog 1 - Homo sapiens (Human) - NDE1 gene Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Taurus_UMD|evm.model.AC_000182.1.292 P35748 MYH11_RABIT 95.233 0.998983 0.997465 MYH11 - Myosin-11 - Oryctolagus cuniculus (Rabbit) - MYH11 gene Muscle contraction. Taurus_UMD|evm.model.AC_000182.1.293 Q96NB1 CEP20_HUMAN 82.759 0.988571 1.00575 CEP20 - Centrosomal protein 20 - Homo sapiens (Human) - CEP20 gene Involved in the biogenesis of cilia (PubMed:20551181). Required for the recruitment of PLK1 to centrosomes and S phase progression (PubMed:24018379). Taurus_UMD|evm.model.AC_000182.1.294 Q8HXQ5 MRP1_BOVIN 98.376 0.980867 1.02484 ABCC1 - Multidrug resistance-associated protein 1 - Bos taurus (Bovine) - ABCC1 gene Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:12067707). Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity). Taurus_UMD|evm.model.AC_000182.1.295 O95255 MRP6_HUMAN 83.644 0.998671 1.00133 ABCC6 - ATP-binding cassette sub-family C member 6 - Homo sapiens (Human) - ABCC6 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:11880368, PubMed:12414644). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin (PubMed:12414644). Taurus_UMD|evm.model.AC_000182.1.296 Q15155 NOMO1_HUMAN 94.910 0.995094 1.00082 NOMO1 - Nodal modulator 1 precursor - Homo sapiens (Human) - NOMO1 gene Component of a ribosome-associated endoplasmic reticulum (ER) translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (PubMed:32820719). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN/Nicalin (By similarity). Taurus_UMD|evm.model.AC_000182.1.297 O46471 RGS16_BOVIN 98.095 0.722222 0.712871 RGS16 - Regulator of G-protein signaling 16 - Bos taurus (Bovine) - RGS16 gene Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals. Taurus_UMD|evm.model.AC_000182.1.298 Q86Y38 XYLT1_HUMAN 94.271 0.997919 1.00209 XYLT1 - Xylosyltransferase 1 - Homo sapiens (Human) - XYLT1 gene Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (PubMed:15461586, PubMed:17189265, PubMed:24581741, PubMed:23982343). Required for normal embryonic and postnatal skeleton development, especially of the long bones (PubMed:24581741, PubMed:23982343). Required for normal maturation of chondrocytes during bone development, and normal onset of ossification (By similarity). Taurus_UMD|evm.model.AC_000182.1.299 P62246 RS15A_RAT 100.000 0.984733 1.00769 Rps15a - 40S ribosomal protein S15a - Rattus norvegicus (Rat) - Rps15a gene Structural component of the ribosome. Required for proper erythropoiesis. Taurus_UMD|evm.model.AC_000182.1.300 Q5R454 AR6P1_PONAB 97.044 0.990196 1.00493 ARL6IP1 - ADP-ribosylation factor-like protein 6-interacting protein 1 - Pongo abelii (Sumatran orangutan) - ARL6IP1 gene Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport. Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Taurus_UMD|evm.model.AC_000182.1.301 Q96Q15 SMG1_HUMAN 98.880 0.999453 0.999454 SMG1 - Serine/threonine-protein kinase SMG1 - Homo sapiens (Human) - SMG1 gene Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. Taurus_UMD|evm.model.AC_000182.1.302 Q6UXS0 CL19A_HUMAN 84.000 0.663102 1.375 CLEC19A - C-type lectin domain family 19 member A precursor - Homo sapiens (Human) - CLEC19A gene Taurus_UMD|evm.model.AC_000182.1.303 Q5R8Q5 SYT17_PONAB 96.809 0.926877 1.06751 SYT17 - Synaptotagmin-17 - Pongo abelii (Sumatran orangutan) - SYT17 gene Plays a role in dendrite formation by melanocytes. Taurus_UMD|evm.model.AC_000182.1.304 Q3MIP1 IPIL2_HUMAN 88.598 0.996248 0.996262 ITPRIPL2 - Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 precursor - Homo sapiens (Human) - ITPRIPL2 gene Taurus_UMD|evm.model.AC_000182.1.305 Q2TBW2 COQ7_BOVIN 100.000 0.990826 1.00461 COQ7 - 5-demethoxyubiquinone hydroxylase, mitochondrial precursor - Bos taurus (Bovine) - COQ7 gene Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner. Taurus_UMD|evm.model.AC_000182.1.306 Q4R7U0 TMC7_MACFA 91.148 0.945026 1.05671 TMC7 - Transmembrane channel-like protein 7 - Macaca fascicularis (Crab-eating macaque) - TMC7 gene Probable ion channel. Taurus_UMD|evm.model.AC_000182.1.307 Q6UXY8 TMC5_HUMAN 77.590 0.99497 0.988072 TMC5 - Transmembrane channel-like protein 5 - Homo sapiens (Human) - TMC5 gene Probable ion channel. Taurus_UMD|evm.model.AC_000182.1.308 Q3T0T0 GDE1_BOVIN 100.000 0.993976 1.00302 GDE1 - Glycerophosphodiester phosphodiesterase 1 - Bos taurus (Bovine) - GDE1 gene Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity). Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and partipates to bioactive N-acylethanolamines biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity). Has little or no activity towards glycerophosphocholine (By similarity). Taurus_UMD|evm.model.AC_000182.1.309 O43303 CP110_HUMAN 82.725 0.998014 0.995059 CCP110 - Centriolar coiled-coil protein of 110 kDa - Homo sapiens (Human) - CCP110 gene Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). Taurus_UMD|evm.model.AC_000182.1.310 Q5R8N4 VP35L_PONAB 97.092 0.997925 1.00104 VPS35L - VPS35 endosomal protein-sorting factor-like - Pongo abelii (Sumatran orangutan) - VPS35L gene Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability. Taurus_UMD|evm.model.AC_000182.1.311 A5D7J3 KNOP1_BOVIN 100.000 0.995585 1.00221 KNOP1 - Lysine-rich nucleolar protein 1 - Bos taurus (Bovine) - KNOP1 gene Taurus_UMD|evm.model.AC_000182.1.312 Q8N0W5 IQCK_HUMAN 74.476 0.993031 1 IQCK - IQ domain-containing protein K - Homo sapiens (Human) - IQCK gene Taurus_UMD|evm.model.AC_000182.1.313 Q9NZH0 GPC5B_HUMAN 88.529 0.960784 1.01241 GPRC5B - G-protein coupled receptor family C group 5 member B precursor - Homo sapiens (Human) - GPRC5B gene Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Taurus_UMD|evm.model.AC_000182.1.314 Q6DWJ6 GP139_HUMAN 96.835 0.755396 1.1813 GPR139 - Probable G-protein coupled receptor 139 - Homo sapiens (Human) - GPR139 gene Orphan receptor. Seems to act through a G(q/11)-mediated pathway. Taurus_UMD|evm.model.AC_000182.1.315 P55259 GP2_HUMAN 76.809 0.996262 0.996276 GP2 - Pancreatic secretory granule membrane major glycoprotein GP2 precursor - Homo sapiens (Human) - GP2 gene Functions as an intestinal M-cells transcytotic receptor specific of type-I-piliated bacteria that participates to the mucosal immune response toward these bacteria. At the apical membrane of M-cells binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to ellicit a mucosal immune response. Taurus_UMD|evm.model.AC_000182.1.316 P48733 UROM_BOVIN 99.689 0.996894 1.00156 UMOD - Uromodulin precursor - Bos taurus (Bovine) - UMOD gene Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. Taurus_UMD|evm.model.AC_000182.1.317 Q8N807 PDILT_HUMAN 76.250 0.950342 1 PDILT - Protein disulfide-isomerase-like protein of the testis precursor - Homo sapiens (Human) - PDILT gene Probable redox-inactive chaperone involved in spermatogenesis. Taurus_UMD|evm.model.AC_000182.1.318 Q6NUN0 ACSM5_HUMAN 90.295 0.974619 1.02073 ACSM5 - Acyl-coenzyme A synthetase ACSM5, mitochondrial precursor - Homo sapiens (Human) - ACSM5 gene Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Taurus_UMD|evm.model.AC_000182.1.319 Q68CK6 ACS2B_HUMAN 77.098 0.987296 0.954939 ACSM2B - Acyl-coenzyme A synthetase ACSM2B, mitochondrial precursor - Homo sapiens (Human) - ACSM2B gene Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065, PubMed:12616642). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10434065, PubMed:12616642). Taurus_UMD|evm.model.AC_000182.1.320 Q9BEA2 ACSM1_BOVIN 99.455 0.612723 1.55286 ACSM1 - Acyl-coenzyme A synthetase ACSM1, mitochondrial precursor - Bos taurus (Bovine) - ACSM1 gene Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11382754, PubMed:10561077). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10561077, PubMed:11382754). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (PubMed:11382754). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (PubMed:11382754). Taurus_UMD|evm.model.AC_000182.1.321 P0C7M7 ACSM4_HUMAN 91.187 0.991071 0.965517 ACSM4 - Acyl-coenzyme A synthetase ACSM4, mitochondrial precursor - Homo sapiens (Human) - ACSM4 gene Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids with a preference for C6-12 fatty acids (By similarity). Taurus_UMD|evm.model.AC_000182.1.322 Q24K03 THUM1_BOVIN 100.000 0.994413 1.0028 THUMPD1 - THUMP domain-containing protein 1 - Bos taurus (Bovine) - THUMPD1 gene Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation. Taurus_UMD|evm.model.AC_000182.1.323 Q5REV5 ACSM3_PONAB 89.483 0.996558 0.991468 ACSM3 - Acyl-coenzyme A synthetase ACSM3, mitochondrial precursor - Pongo abelii (Sumatran orangutan) - ACSM3 gene Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms (By similarity). Taurus_UMD|evm.model.AC_000182.1.324 A8K979 ERI2_HUMAN 78.468 0.997101 0.998553 ERI2 - ERI1 exoribonuclease 2 - Homo sapiens (Human) - ERI2 gene 3'-5'-exoribonuclease activity, DNA catabolic process, exonucleolytic, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Taurus_UMD|evm.model.AC_000182.1.325 Q2T9U5 REXO5_BOVIN 100.000 0.997449 1.00128 REXO5 - RNA exonuclease 5 - Bos taurus (Bovine) - REXO5 gene nucleus, exonuclease activity Taurus_UMD|evm.model.AC_000182.1.326 Q5E9V1 DCNL3_BOVIN 100.000 0.993443 1.00329 DCUN1D3 - DCN1-like protein 3 - Bos taurus (Bovine) - DCUN1D3 gene Contributes to the neddylation of all cullins by transfering NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage. At the cell membrane, can promote and as well inhibit cullins neddylation. Taurus_UMD|evm.model.AC_000182.1.327 O43615 TIM44_HUMAN 77.119 0.97479 0.263274 TIMM44 - Mitochondrial import inner membrane translocase subunit TIM44 precursor - Homo sapiens (Human) - TIMM44 gene Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). Taurus_UMD|evm.model.AC_000182.1.328 O43615 TIM44_HUMAN 66.146 0.988439 0.382743 TIMM44 - Mitochondrial import inner membrane translocase subunit TIM44 precursor - Homo sapiens (Human) - TIMM44 gene Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). Taurus_UMD|evm.model.AC_000182.1.329 O43325 LYRM1_HUMAN 92.623 0.98374 1.0082 LYRM1 - LYR motif-containing protein 1 - Homo sapiens (Human) - LYRM1 gene May promote cell proliferation and inhibition of apoptosis of preadipocytes. Taurus_UMD|evm.model.AC_000182.1.330 Q8TD57 DYH3_HUMAN 88.869 0.999261 0.657434 DNAH3 - Dynein axonemal heavy chain 3 - Homo sapiens (Human) - DNAH3 gene Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Taurus_UMD|evm.model.AC_000182.1.331 Q96B96 LDAF1_HUMAN 73.292 0.987654 1.00621 TMEM159 - Lipid droplet assembly factor 1 - Homo sapiens (Human) - TMEM159 gene Plays an important role in the formation of lipid droplets (LD) which are storage organelles at the center of lipid and energy homeostasis (PubMed:31708432). In association with BSCL2/seipin, defines the sites of LD formation in the endoplasmic reticulum (PubMed:31708432). Taurus_UMD|evm.model.AC_000182.1.332 Q9BH10 ZP2_BOVIN 99.568 0.931452 1.04348 ZP2 - Zona pellucida sperm-binding protein 2 precursor - Bos taurus (Bovine) - ZP2 gene Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. Taurus_UMD|evm.model.AC_000182.1.333 Q8N8V4 ANS4B_HUMAN 86.571 0.995157 0.990408 ANKS4B - Ankyrin repeat and SAM domain-containing protein 4B - Homo sapiens (Human) - ANKS4B gene As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (PubMed:26812018). May play a role in cellular response to endoplasmic reticulum stress (By similarity). Taurus_UMD|evm.model.AC_000182.1.334 Q2KHX6 CRYM_BOVIN 100.000 0.993651 1.00318 CRYM - Ketimine reductase mu-crystallin - Bos taurus (Bovine) - CRYM gene Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity). Taurus_UMD|evm.model.AC_000182.1.335 Q99758 ABCA3_HUMAN 45.785 0.993618 0.919601 ABCA3 - Phospholipid-transporting ATPase ABCA3 - Homo sapiens (Human) - ABCA3 gene Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:16959783, PubMed:17574245, PubMed:28887056, PubMed:31473345, PubMed:27177387). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:27177387). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (PubMed:26903515, PubMed:25817392, PubMed:27177387). Taurus_UMD|evm.model.AC_000182.1.336 Q8R420 ABCA3_MOUSE 46.554 0.995092 0.956573 Abca3 - Phospholipid-transporting ATPase ABCA3 - Mus musculus (Mouse) - Abca3 gene Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:17577581, PubMed:17540762, PubMed:17267394, PubMed:17142808, PubMed:20190032, PubMed:28034695). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:17142808). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (By similarity). Taurus_UMD|evm.model.AC_000182.1.337 P23004 QCR2_BOVIN 100.000 0.995595 1.00221 UQCRC2 - Cytochrome b-c1 complex subunit 2, mitochondrial precursor - Bos taurus (Bovine) - UQCRC2 gene Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (PubMed:9694818, PubMed:11073949). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Taurus_UMD|evm.model.AC_000182.1.338 Q32KW7 PDZD9_BOVIN 100.000 0.992424 1.0038 PDZD9 - PDZ domain-containing protein 9 - Bos taurus (Bovine) - PDZD9 gene Taurus_UMD|evm.model.AC_000182.1.339 Q8C784 MOSMO_MOUSE 100.000 0.988095 1.00599 Mosmo - Modulator of smoothened protein - Mus musculus (Mouse) - Mosmo gene Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane (PubMed:29290584). Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation (PubMed:29290584). Taurus_UMD|evm.model.AC_000182.1.340 A6NCI4 VWA3A_HUMAN 78.974 0.99744 0.989865 VWA3A - von Willebrand factor A domain-containing protein 3A precursor - Homo sapiens (Human) - VWA3A gene Taurus_UMD|evm.model.AC_000182.1.341 A6NKP2 D42E2_HUMAN 89.610 0.843407 0.862559 SDR42E2 - Putative short-chain dehydrogenase/reductase family 42E member 2 - Homo sapiens (Human) - SDR42E2 gene oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Taurus_UMD|evm.model.AC_000182.1.342 O00418 EF2K_HUMAN 90.483 0.997238 0.998621 EEF2K - Eukaryotic elongation factor 2 kinase - Homo sapiens (Human) - EEF2K gene Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. Taurus_UMD|evm.model.AC_000182.1.343 Q9NVU0 RPC5_HUMAN 90.717 0.997122 0.981638 POLR3E - DNA-directed RNA polymerase III subunit RPC5 - Homo sapiens (Human) - POLR3E gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Taurus_UMD|evm.model.AC_000182.1.344 Q01850 CDR2_HUMAN 90.789 0.995624 1.00661 CDR2 - Cerebellar degeneration-related protein 2 - Homo sapiens (Human) - CDR2 gene Taurus_UMD|evm.model.AC_000182.1.345 Q5ZKJ5 MF13A_CHICK 28.571 0.979358 0.856582 MFSD13A - Transmembrane protein 180 - Gallus gallus (Chicken) - MFSD13A gene Taurus_UMD|evm.model.AC_000182.1.346 Q0VCJ8 METL9_BOVIN 100.000 0.99373 1.00314 METTL9 - Protein-L-histidine N-pros-methyltransferase precursor - Bos taurus (Bovine) - METTL9 gene Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins. Mediates methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins. Constitutes the main methyltransferase for the 1-methylhistidine modification in cell. Taurus_UMD|evm.model.AC_000182.1.350 Q5RE65 CWC15_PONAB 77.966 0.647727 0.384279 CWC15 - Spliceosome-associated protein CWC15 homolog - Pongo abelii (Sumatran orangutan) - CWC15 gene Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Taurus_UMD|evm.model.AC_000182.1.351 Q9Y278 HS3S2_HUMAN 93.902 0.840206 0.52861 HS3ST2 - Heparan sulfate glucosamine 3-O-sulfotransferase 2 - Homo sapiens (Human) - HS3ST2 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. Taurus_UMD|evm.model.AC_000182.1.352 Q9Y278 HS3S2_HUMAN 98.537 0.990291 0.561308 HS3ST2 - Heparan sulfate glucosamine 3-O-sulfotransferase 2 - Homo sapiens (Human) - HS3ST2 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. Taurus_UMD|evm.model.AC_000182.1.353 Q70CQ4 UBP31_HUMAN 92.747 0.957746 0.945266 USP31 - Ubiquitin carboxyl-terminal hydrolase 31 - Homo sapiens (Human) - USP31 gene May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Taurus_UMD|evm.model.AC_000182.1.354 F1MJW3 SCNNG_BOVIN 100.000 0.911142 1.08742 SCNN1G - Amiloride-sensitive sodium channel subunit gamma - Bos taurus (Bovine) - SCNN1G gene Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Taurus_UMD|evm.model.AC_000182.1.355 A5D7U4 SCNNB_BOVIN 100.000 0.868385 1.14977 SCNN1B - Amiloride-sensitive sodium channel subunit beta - Bos taurus (Bovine) - SCNN1B gene Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Taurus_UMD|evm.model.AC_000182.1.356 A2VDR8 COG7_BOVIN 100.000 0.997406 1.0013 COG7 - Conserved oligomeric Golgi complex subunit 7 - Bos taurus (Bovine) - COG7 gene Required for normal Golgi function. Taurus_UMD|evm.model.AC_000182.1.357 Q9UJY4 GGA2_HUMAN 90.395 0.963272 0.977162 GGA2 - ADP-ribosylation factor-binding protein GGA2 - Homo sapiens (Human) - GGA2 gene Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). Taurus_UMD|evm.model.AC_000182.1.358 Q5JPH6 SYEM_HUMAN 87.598 0.960227 1.00956 EARS2 - Probable glutamate--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - EARS2 gene Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). Taurus_UMD|evm.model.AC_000182.1.359 O14562 UBFD1_HUMAN 85.437 0.99262 0.877023 UBFD1 - Ubiquitin domain-containing protein UBFD1 - Homo sapiens (Human) - UBFD1 gene May play a role as NF-kappa-B regulator. Taurus_UMD|evm.model.AC_000182.1.360 P52505 ACPM_BOVIN 99.359 0.987261 1.00641 NDUFAB1 - Acyl carrier protein, mitochondrial precursor - Bos taurus (Bovine) - NDUFAB1 gene Carrier of the growing fatty acid chain in fatty acid biosynthesis (PubMed:1907568). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:1907568, PubMed:10852722, PubMed:18721790). Taurus_UMD|evm.model.AC_000182.1.361 Q86YC2 PALB2_HUMAN 67.420 0.990803 1.00843 PALB2 - Partner and localizer of BRCA2 - Homo sapiens (Human) - PALB2 gene Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19423707, PubMed:19369211, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). Taurus_UMD|evm.model.AC_000182.1.362 Q9BTE1 DCTN5_HUMAN 99.451 0.989071 1.00549 DCTN5 - Dynactin subunit 5 - Homo sapiens (Human) - DCTN5 gene centrosome, cytosol, nuclear membrane, nucleoplasm, antigen processing and presentation of exogenous peptide antigen via MHC class II, endoplasmic reticulum to Golgi vesicle-mediated transport Taurus_UMD|evm.model.AC_000182.1.363 Q2TA25 PLK1_BOVIN 100.000 0.996683 1.00166 PLK1 - Serine/threonine-protein kinase PLK1 - Bos taurus (Bovine) - PLK1 gene Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis.Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning. Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Phosphorylates CEP68 and is required for its degradation. Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope. Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock. Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression. Regulates mitotic progression by phosphorylating RIOK2 (By similarity). Taurus_UMD|evm.model.AC_000182.1.364 Q76MJ5 ERN2_HUMAN 85.437 0.99676 1 ERN2 - Serine/threonine-protein kinase/endoribonuclease IRE2 precursor - Homo sapiens (Human) - ERN2 gene Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. Taurus_UMD|evm.model.AC_000182.1.365 O43745 CHP2_HUMAN 85.204 0.989848 1.0051 CHP2 - Calcineurin B homologous protein 2 - Homo sapiens (Human) - CHP2 gene Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. Taurus_UMD|evm.model.AC_000182.1.366 P05126 KPCB_BOVIN 100.000 0.997024 1.00149 PRKCB - Protein kinase C beta type - Bos taurus (Bovine) - PRKCB gene Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (By similarity). Taurus_UMD|evm.model.AC_000182.1.367 Q0VD05 CCG3_BOVIN 95.785 0.938628 0.879365 CACNG3 - Voltage-dependent calcium channel gamma-3 subunit - Bos taurus (Bovine) - CACNG3 gene Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Taurus_UMD|evm.model.AC_000182.1.368 Q7Z6E9 RBBP6_HUMAN 91.860 0.669077 1.00335 RBBP6 - E3 ubiquitin-protein ligase RBBP6 - Homo sapiens (Human) - RBBP6 gene E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Taurus_UMD|evm.model.AC_000182.1.369 Q09138 AAKG1_PIG 40.602 0.947674 0.521212 PRKAG1 - 5'-AMP-activated protein kinase subunit gamma-1 - Sus scrofa (Pig) - PRKAG1 gene AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (By similarity). Taurus_UMD|evm.model.AC_000182.1.370 Q8NDV7 TNR6A_HUMAN 93.431 0.969405 0.899592 TNRC6A - Trinucleotide repeat-containing gene 6A protein - Homo sapiens (Human) - TNRC6A gene Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. Taurus_UMD|evm.model.AC_000182.1.371 Q3ZC26 SC5AB_BOVIN 100.000 0.997037 1.00148 SLC5A11 - Sodium/myo-inositol cotransporter 2 - Bos taurus (Bovine) - SLC5A11 gene Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney. Taurus_UMD|evm.model.AC_000182.1.374 Q68EM7 RHG17_HUMAN 89.850 0.977117 0.992054 ARHGAP17 - Rho GTPase-activating protein 17 - Homo sapiens (Human) - ARHGAP17 gene Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. Taurus_UMD|evm.model.AC_000182.1.376 Q15643 TRIPB_HUMAN 49.289 0.967568 0.0934816 TRIP11 - Thyroid receptor-interacting protein 11 - Homo sapiens (Human) - TRIP11 gene Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Taurus_UMD|evm.model.AC_000182.1.377 Q15643 TRIPB_HUMAN 44.878 0.988571 0.0884285 TRIP11 - Thyroid receptor-interacting protein 11 - Homo sapiens (Human) - TRIP11 gene Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Taurus_UMD|evm.model.AC_000182.1.378 Q3T0H0 LCMT1_BOVIN 100.000 0.9125 0.481928 LCMT1 - Leucine carboxyl methyltransferase 1 - Bos taurus (Bovine) - LCMT1 gene Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Taurus_UMD|evm.model.AC_000182.1.379 Q3T0H0 LCMT1_BOVIN 98.266 0.354639 1.46084 LCMT1 - Leucine carboxyl methyltransferase 1 - Bos taurus (Bovine) - LCMT1 gene Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Taurus_UMD|evm.model.AC_000182.1.380 Q63HK3 ZKSC2_HUMAN 85.759 0.997938 1.0031 ZKSCAN2 - Zinc finger protein with KRAB and SCAN domains 2 - Homo sapiens (Human) - ZKSCAN2 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.381 Q9Y661 HS3S4_HUMAN 90.722 0.768595 0.265351 HS3ST4 - Heparan sulfate glucosamine 3-O-sulfotransferase 4 - Homo sapiens (Human) - HS3ST4 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). Taurus_UMD|evm.model.AC_000182.1.382 Q9Y661 HS3S4_HUMAN 91.489 0.754839 0.679825 HS3ST4 - Heparan sulfate glucosamine 3-O-sulfotransferase 4 - Homo sapiens (Human) - HS3ST4 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). Taurus_UMD|evm.model.AC_000182.1.383 Q32L59 TMC5B_BOVIN 91.837 0.13079 1.04558 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Taurus_UMD|evm.model.AC_000182.1.385 Q7Z2V1 TNT_HUMAN 48.438 0.651282 0.898618 C16orf82 - Protein TNT - Homo sapiens (Human) - C16orf82 gene Taurus_UMD|evm.model.AC_000182.1.387 Q3T0X7 NSE1_BOVIN 99.545 0.779359 1.05639 NSMCE1 - Non-structural maintenance of chromosomes element 1 homolog - Bos taurus (Bovine) - NSMCE1 gene RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair. Taurus_UMD|evm.model.AC_000182.1.389 Q1JP61 KDM8_BOVIN 92.661 0.995423 1.07635 KDM8 - Bifunctional peptidase and arginyl-hydroxylase JMJD5 - Bos taurus (Bovine) - KDM8 gene Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase. Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation. Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity. Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage. Additionnally, acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established. Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation. Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition. Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation. Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (By similarity). Regulates the circadian gene expression in the liver (By similarity). Represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a catalytically-independent manner (By similarity). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (By similarity). Taurus_UMD|evm.model.AC_000182.1.390 Q3T0X7 NSE1_BOVIN 100.000 0.171103 0.988722 NSMCE1 - Non-structural maintenance of chromosomes element 1 homolog - Bos taurus (Bovine) - NSMCE1 gene RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair. Taurus_UMD|evm.model.AC_000182.1.392 Q863Z5 IL4RA_PIG 72.973 0.953069 1.0012 IL4R - Interleukin-4 receptor subunit alpha precursor - Sus scrofa (Pig) - IL4R gene Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). Taurus_UMD|evm.model.AC_000182.1.393 Q9HBE5 IL21R_HUMAN 63.004 0.996241 0.988848 IL21R - Interleukin-21 receptor precursor - Homo sapiens (Human) - IL21R gene This is a receptor for interleukin-21. Taurus_UMD|evm.model.AC_000182.1.394 Q12789 TF3C1_HUMAN 79.405 0.999046 0.99431 GTF3C1 - General transcription factor 3C polypeptide 1 - Homo sapiens (Human) - GTF3C1 gene Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. Taurus_UMD|evm.model.AC_000182.1.395 O60303 KATIP_HUMAN 75.783 0.996283 0.997528 KATNIP - Katanin-interacting protein - Homo sapiens (Human) - KATNIP gene May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex. Taurus_UMD|evm.model.AC_000182.1.396 Q6UXU4 GSG1L_HUMAN 95.181 0.993958 1 GSG1L - Germ cell-specific gene 1-like protein - Homo sapiens (Human) - GSG1L gene As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating. Taurus_UMD|evm.model.AC_000182.1.397 Q96QU8 XPO6_HUMAN 98.044 0.998224 1.00089 XPO6 - Exportin-6 - Homo sapiens (Human) - XPO6 gene Mediates the nuclear export of actin and profilin-actin complexes in somatic cells. Taurus_UMD|evm.model.AC_000182.1.399 Q52WX2 SBK1_HUMAN 99.582 0.68 0.825472 SBK1 - Serine/threonine-protein kinase SBK1 - Homo sapiens (Human) - SBK1 gene May be involved in signal-transduction pathways related to the control of brain development. Taurus_UMD|evm.model.AC_000182.1.400 Q3SZR9 TSN3_BOVIN 92.701 0.978417 0.549407 TSPAN3 - Tetraspanin-3 - Bos taurus (Bovine) - TSPAN3 gene Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair. Taurus_UMD|evm.model.AC_000182.1.401 O43561 LAT_HUMAN 65.417 0.901961 0.973282 LAT - Linker for activation of T-cells family member 1 - Homo sapiens (Human) - LAT gene Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. Taurus_UMD|evm.model.AC_000182.1.402 Q08DX7 SPNS1_BOVIN 100.000 0.996219 1.00189 SPNS1 - Protein spinster homolog 1 - Bos taurus (Bovine) - SPNS1 gene Sphingolipid transporter. May be involved in necrotic or autophagic cell death (By similarity). Taurus_UMD|evm.model.AC_000182.1.403 Q8NCF5 NF2IP_HUMAN 77.403 0.916268 0.997613 NFATC2IP - NFATC2-interacting protein - Homo sapiens (Human) - NFATC2IP gene In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). Taurus_UMD|evm.model.AC_000182.1.404 P15391 CD19_HUMAN 63.345 0.991135 1.01439 CD19 - B-lymphocyte antigen CD19 precursor - Homo sapiens (Human) - CD19 gene Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:2463100, PubMed:1373518, PubMed:16672701). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:9382888, PubMed:9317126, PubMed:12387743, PubMed:16672701). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126). Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:2463100, PubMed:1373518). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:9317126, PubMed:12387743, PubMed:16672701). Taurus_UMD|evm.model.AC_000182.1.405 A4FUG8 RABE2_BOVIN 100.000 0.996587 1.00171 RABEP2 - Rab GTPase-binding effector protein 2 - Bos taurus (Bovine) - RABEP2 gene Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis. Taurus_UMD|evm.model.AC_000182.1.406 Q0VCY0 AT2A1_BOVIN 98.389 0.898711 1.09366 ATP2A1 - Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 - Bos taurus (Bovine) - ATP2A1 gene Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:22387132). Contributes to calcium sequestration involved in muscular excitation/contraction. Taurus_UMD|evm.model.AC_000182.1.407 Q9NRF2 SH2B1_HUMAN 94.462 0.938897 0.887566 SH2B1 - SH2B adapter protein 1 - Homo sapiens (Human) - SH2B1 gene Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis (By similarity). Taurus_UMD|evm.model.AC_000182.1.408 P49410 EFTU_BOVIN 100.000 0.995585 1.00221 TUFM - Elongation factor Tu, mitochondrial precursor - Bos taurus (Bovine) - TUFM gene Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. Taurus_UMD|evm.model.AC_000182.1.409 Q8WWM7 ATX2L_HUMAN 96.289 0.984991 0.991628 ATXN2L - Ataxin-2-like protein - Homo sapiens (Human) - ATXN2L gene Involved in the regulation of stress granule and P-body formation. Taurus_UMD|evm.model.AC_000182.1.410 Q3SYW6 EIF3C_BOVIN 100.000 0.997809 1.0011 EIF3C - Eukaryotic translation initiation factor 3 subunit C - Bos taurus (Bovine) - EIF3C gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Taurus_UMD|evm.model.AC_000182.1.411 Q60HH0 CLN3_MACFA 88.584 0.995444 1.00228 CLN3 - Battenin precursor - Macaca fascicularis (Crab-eating macaque) - CLN3 gene Mediates microtubule-dependent, anterograde transport connecting the Golgi network, endosomes, autophagosomes, lysosomes and plasma membrane, and participates in several cellular processes such as regulation of lysosomal pH, lysosome protein degradation, receptor-mediated endocytosis, autophagy, transport of proteins and lipids from the TGN, apoptosis and synaptic transmission. Facilitates the proteins transport from trans-Golgi network (TGN)-to other membrane compartments such as transport of microdomain-associated proteins to the plasma membrane, IGF2R transport to the lysosome where it regulates the CTSD release leading to regulation of CTSD maturation and thereby APP intracellular processing (By similarity). Moreover regulates CTSD activity in response to osmotic stress (By similarity). Also binds galactosylceramide and transports it from the trans Golgi to the rafts, which may have immediate and downstream effects on cell survival by modulating ceramide synthesis. At the plasma membrane, regulates actin-dependent events including filopodia formation, cell migration, and pinocytosis through ARF1-CDC42 pathway and also the cytoskeleton organization through interaction with MYH10 and fodrin leading to the regulation of the plasma membrane association of Na+, K+ ATPase complex. Regulates synaptic transmission in the amygdala, hippocampus, and cerebellum through regulation of synaptic vesicles density and their proximity to active zones leading to modulation of short-term plasticity and age-dependent anxious behavior, learning and memory. Regulates autophagic vacuoles (AVs) maturation by modulating the trafficking between endocytic and autophagolysosomal/lysosomal compartments, which involves vesicle fusion leading to regulation of degradation process. Participates also in cellular homeostasis of compounds such as, water, ions, amino acids, proteins and lipids in several tissue namely in brain and kidney through regulation of their transport and synthesis (By similarity). Taurus_UMD|evm.model.AC_000182.1.412 Q0VD83 APOBR_HUMAN 62.925 0.26219 0.990884 APOBR - Apolipoprotein B receptor - Homo sapiens (Human) - APOBR gene Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. Taurus_UMD|evm.model.AC_000182.1.413 Q5S1V9 IL27A_PIG 84.100 0.991597 0.995816 IL27 - Interleukin-27 subunit alpha precursor - Sus scrofa (Pig) - IL27 gene Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II (By similarity). Taurus_UMD|evm.model.AC_000182.1.414 O60356 NUPR1_HUMAN 82.716 0.963855 1.0122 NUPR1 - Nuclear protein 1 - Homo sapiens (Human) - NUPR1 gene Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in regulation of many process namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:16478804, PubMed:19650074, PubMed:16300740, PubMed:19723804, PubMed:11056169, PubMed:22858377, PubMed:11940591, PubMed:18690848, PubMed:22565310, PubMed:20181828, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity). Taurus_UMD|evm.model.AC_000182.1.415 Q96ES7 SGF29_HUMAN 100.000 0.960526 0.259386 SGF29 - SAGA-associated factor 29 - Homo sapiens (Human) - SGF29 gene Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581). Taurus_UMD|evm.model.AC_000182.1.416 Q96ES7 SGF29_HUMAN 96.581 0.789116 0.501706 SGF29 - SAGA-associated factor 29 - Homo sapiens (Human) - SGF29 gene Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581). Taurus_UMD|evm.model.AC_000182.1.417 P0C606 SGF29_RAT 100.000 0.866667 0.358362 Sgf29 - SAGA-associated factor 29 - Rattus norvegicus (Rat) - Sgf29 gene Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:17334388). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (By similarity). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (By similarity). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (By similarity). May be involved in MYC-mediated oncogenic transformation (PubMed:17334388). Taurus_UMD|evm.model.AC_000182.1.418 P50227 ST1A1_BOVIN 100.000 0.993243 1.00339 SULT1A1 - Sulfotransferase 1A1 - Bos taurus (Bovine) - SULT1A1 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (By similarity). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil. Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity). Taurus_UMD|evm.model.AC_000182.1.419 Q32PI0 SLX1_BOVIN 100.000 0.992537 1.00375 SLX1A - Structure-specific endonuclease subunit SLX1 - Bos taurus (Bovine) - SLX1A gene Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Taurus_UMD|evm.model.AC_000182.1.420 Q9H3K6 BOLA2_HUMAN 91.860 0.977011 1.01163 BOLA2 - BolA-like protein 2 - Homo sapiens (Human) - BOLA2 gene Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415). Taurus_UMD|evm.model.AC_000182.1.421 Q92176 COR1A_BOVIN 100.000 0.874525 1.141 CORO1A - Coronin-1A - Bos taurus (Bovine) - CORO1A gene May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected macrophages, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes (By similarity). Taurus_UMD|evm.model.AC_000182.1.422 P27361 MK03_HUMAN 98.143 0.986877 1.00528 MAPK3 - Mitogen-activated protein kinase 3 - Homo sapiens (Human) - MAPK3 gene Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Taurus_UMD|evm.model.AC_000182.1.423 Q7L5L3 GDPD3_HUMAN 82.680 0.956113 1.00314 GDPD3 - Lysophospholipase D GDPD3 - Homo sapiens (Human) - GDPD3 gene Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:27637550). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso-PC) and N-acylethanolamine lysophospholipids (PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. Taurus_UMD|evm.model.AC_000182.1.424 P61237 YPEL3_MOUSE 100.000 0.983333 1.0084 Ypel3 - Protein yippee-like 3 - Mus musculus (Mouse) - Ypel3 gene Involved in proliferation and apoptosis in myeloid precursor cells. Taurus_UMD|evm.model.AC_000182.1.425 E1BEA8 TBX6_BOVIN 100.000 0.746575 0.958425 TBX6 - T-box transcription factor TBX6 - Bos taurus (Bovine) - TBX6 gene T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to also play an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). Taurus_UMD|evm.model.AC_000182.1.426 Q5R6K8 PP4C_PONAB 100.000 0.993506 1.00326 PPP4C - Serine/threonine-protein phosphatase 4 catalytic subunit - Pongo abelii (Sumatran orangutan) - PPP4C gene Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin (By similarity). Taurus_UMD|evm.model.AC_000182.1.427 P04075 ALDOA_HUMAN 97.802 0.726 1.37363 ALDOA - Fructose-bisphosphate aldolase A - Homo sapiens (Human) - ALDOA gene Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Taurus_UMD|evm.model.AC_000182.1.428 Q71RH2 TLC3B_HUMAN 81.356 0.951351 0.675182 TLCD3B - Ceramide synthase - Homo sapiens (Human) - TLCD3B gene Involved in ceramide synthesis. Taurus_UMD|evm.model.AC_000182.1.429 Q96LL3 FIMP_HUMAN 74.157 0.676923 0.984848 FIMP - Fertilization-influencing membrane protein - Homo sapiens (Human) - FIMP gene May play a role in sperm-oocyte fusion during fertilization. Taurus_UMD|evm.model.AC_000182.1.430 Q14183 DOC2A_HUMAN 96.010 0.995025 1.005 DOC2A - Double C2-like domain-containing protein alpha - Homo sapiens (Human) - DOC2A gene Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. Taurus_UMD|evm.model.AC_000182.1.431 Q29RS4 IN80E_BOVIN 94.262 0.991342 0.946721 INO80E - INO80 complex subunit E - Bos taurus (Bovine) - INO80E gene Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Taurus_UMD|evm.model.AC_000182.1.432 Q9BW71 HIRP3_HUMAN 66.949 0.99651 1.03058 HIRIP3 - HIRA-interacting protein 3 - Homo sapiens (Human) - HIRIP3 gene May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. Taurus_UMD|evm.model.AC_000182.1.433 Q5R4F3 TAOK3_PONAB 72.222 0.583062 0.341871 TAOK3 - Serine/threonine-protein kinase TAO3 - Pongo abelii (Sumatran orangutan) - TAOK3 gene Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity). Taurus_UMD|evm.model.AC_000182.1.434 Q9UL54 TAOK2_HUMAN 92.880 0.998355 0.984615 TAOK2 - Serine/threonine-protein kinase TAO2 - Homo sapiens (Human) - TAOK2 gene Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. Taurus_UMD|evm.model.AC_000182.1.435 Q1JQE1 TM219_BOVIN 100.000 0.991667 1.00418 TMEM219 - Insulin-like growth factor-binding protein 3 receptor precursor - Bos taurus (Bovine) - TMEM219 gene Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding. Taurus_UMD|evm.model.AC_000182.1.436 Q2T9W0 BACD1_BOVIN 99.696 0.993939 1.00304 KCTD13 - BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 - Bos taurus (Bovine) - KCTD13 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission. Taurus_UMD|evm.model.AC_000182.1.437 A1L515 ASPH1_BOVIN 100.000 0.99187 0.6703 ASPHD1 - Aspartate beta-hydroxylase domain-containing protein 1 - Bos taurus (Bovine) - ASPHD1 gene Taurus_UMD|evm.model.AC_000182.1.438 Q29RN8 SE6L2_BOVIN 98.592 0.997835 1.01538 SEZ6L2 - Seizure 6-like protein 2 precursor - Bos taurus (Bovine) - SEZ6L2 gene May contribute to specialized endoplasmic reticulum functions in neurons. Taurus_UMD|evm.model.AC_000182.1.439 P0DO93 ENOL_RAT 68.478 0.735537 1.35955 T-enol - Putative protein T-ENOL - Rattus norvegicus (Rat) - T-enol gene Taurus_UMD|evm.model.AC_000182.1.440 P70500 CDIPT_RAT 96.244 0.990654 1.00469 Cdipt - CDP-diacylglycerol--inositol 3-phosphatidyltransferase - Rattus norvegicus (Rat) - Cdipt gene Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. Taurus_UMD|evm.model.AC_000182.1.441 Q3SYU9 MVP_BOVIN 99.888 0.997755 1.00112 MVP - Major vault protein - Bos taurus (Bovine) - MVP gene Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity). Taurus_UMD|evm.model.AC_000182.1.442 Q1LZ80 PAGR1_BOVIN 100.000 0.992126 1.00395 PAGR1 - PAXIP1-associated glutamate-rich protein 1 - Bos taurus (Bovine) - PAGR1 gene Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition. Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent. Taurus_UMD|evm.model.AC_000182.1.443 Q5RAC1 PRRT2_PONAB 80.347 0.994236 1.02059 PRRT2 - Proline-rich transmembrane protein 2 - Pongo abelii (Sumatran orangutan) - PRRT2 gene As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. Taurus_UMD|evm.model.AC_000182.1.444 A6QPL4 KIF22_BOVIN 100.000 0.836788 1.16616 KIF22 - Kinesin-like protein KIF22 - Bos taurus (Bovine) - KIF22 gene Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. Taurus_UMD|evm.model.AC_000182.1.445 O60844 ZG16_HUMAN 80.240 0.988095 1.00599 ZG16 - Zymogen granule membrane protein 16 precursor - Homo sapiens (Human) - ZG16 gene May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN. Taurus_UMD|evm.model.AC_000182.1.446 Q6UWD8 CP054_HUMAN 75.893 0.951754 1.01786 C16orf54 - Transmembrane protein C16orf54 - Homo sapiens (Human) - C16orf54 gene Taurus_UMD|evm.model.AC_000182.1.447 Q3T063 NADC_BOVIN 99.666 0.993333 1.00334 QPRT - Nicotinate-nucleotide pyrophosphorylase [carboxylating] - Bos taurus (Bovine) - QPRT gene Involved in the catabolism of quinolinic acid (QA). Taurus_UMD|evm.model.AC_000182.1.448 P16150 LEUK_HUMAN 51.235 0.656315 1.2075 SPN - Leukosialin precursor - Homo sapiens (Human) - SPN gene Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity). Taurus_UMD|evm.model.AC_000182.1.449 Q9CWK3 CD2B2_MOUSE 88.338 0.994152 1 Cd2bp2 - CD2 antigen cytoplasmic tail-binding protein 2 - Mus musculus (Mouse) - Cd2bp2 gene Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. Taurus_UMD|evm.model.AC_000182.1.450 Q8BH49 SESQ1_MOUSE 45.802 0.623188 0.778195 Pheta1 - Sesquipedalian-1 - Mus musculus (Mouse) - Pheta1 gene Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. Taurus_UMD|evm.model.AC_000182.1.451 Q4KMP7 TB10B_HUMAN 89.791 0.997509 0.993812 TBC1D10B - TBC1 domain family member 10B - Homo sapiens (Human) - TBC1D10B gene Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A. Taurus_UMD|evm.model.AC_000182.1.452 Q0P571 MLRS_BOVIN 100.000 0.988304 1.00588 MYLPF - Myosin regulatory light chain 2, skeletal muscle isoform - Bos taurus (Bovine) - MYLPF gene Taurus_UMD|evm.model.AC_000182.1.453 A5PJU9 SEPT1_BOVIN 100.000 0.994565 1.00272 SEPTIN1 - Septin-1 - Bos taurus (Bovine) - SEPTIN1 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Taurus_UMD|evm.model.AC_000182.1.454 Q96MX3 ZNF48_HUMAN 92.823 0.99681 1.01456 ZNF48 - Zinc finger protein 48 - Homo sapiens (Human) - ZNF48 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.455 Q7L3S4 ZN771_HUMAN 94.637 0.993651 0.993691 ZNF771 - Zinc finger protein 771 - Homo sapiens (Human) - ZNF771 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.456 Q32KY6 DCTP1_BOVIN 99.408 0.988235 1.00592 DCTPP1 - dCTP pyrophosphatase 1 - Bos taurus (Bovine) - DCTPP1 gene Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. Taurus_UMD|evm.model.AC_000182.1.457 P97364 SPS2_MOUSE 96.785 0.936556 0.732301 Sephs2 - Selenide, water dikinase 2 - Mus musculus (Mouse) - Sephs2 gene Synthesizes selenophosphate from selenide and ATP. Taurus_UMD|evm.model.AC_000182.1.458 P61625 ITAL_BOVIN 99.657 0.998279 0.997425 ITGAL - Integrin alpha-L precursor - Bos taurus (Bovine) - ITGAL gene Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. Taurus_UMD|evm.model.AC_000182.1.459 Q9H5H4 ZN768_HUMAN 90.196 0.996441 1.04074 ZNF768 - Zinc finger protein 768 - Homo sapiens (Human) - ZNF768 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.460 Q96H86 ZN764_HUMAN 77.136 0.961165 1.0098 ZNF764 - Zinc finger protein 764 - Homo sapiens (Human) - ZNF764 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.461 P0C7X2 ZN688_HUMAN 84.791 0.945848 1.00362 ZNF688 - Zinc finger protein 688 - Homo sapiens (Human) - ZNF688 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.462 P05114 HMGN1_HUMAN 59.459 0.741935 0.93 HMGN1 - Non-histone chromosomal protein HMG-14 - Homo sapiens (Human) - HMGN1 gene Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). Taurus_UMD|evm.model.AC_000182.1.463 Q96CS4 ZN689_HUMAN 92.814 0.994012 1.002 ZNF689 - Zinc finger protein 689 - Homo sapiens (Human) - ZNF689 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.464 Q0VBZ8 PRR14_BOVIN 100.000 0.864307 1.15503 PRR14 - Proline-rich protein 14 - Bos taurus (Bovine) - PRR14 gene Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha. Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit. Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha. Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (By similarity). Taurus_UMD|evm.model.AC_000182.1.465 Q9HAH7 FBRS_HUMAN 97.835 0.46945 2.13478 FBRS - Probable fibrosin-1 - Homo sapiens (Human) - FBRS gene Taurus_UMD|evm.model.AC_000182.1.466 Q6ZRS2 SRCAP_HUMAN 89.698 0.928676 1.05913 SRCAP - Helicase SRCAP - Homo sapiens (Human) - SRCAP gene Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. Taurus_UMD|evm.model.AC_000182.1.467 Q2KJ16 PHKG2_BOVIN 100.000 0.995086 1.00246 PHKG2 - Phosphorylase b kinase gamma catalytic chain, liver/testis isoform - Bos taurus (Bovine) - PHKG2 gene Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity). Taurus_UMD|evm.model.AC_000182.1.468 A1A4V9 CC189_HUMAN 76.807 0.993994 1.00604 CCDC189 - Coiled-coil domain-containing protein 189 - Homo sapiens (Human) - CCDC189 gene Taurus_UMD|evm.model.AC_000182.1.469 Q5RAU7 BRE1B_PONAB 95.904 0.998004 1.001 RNF40 - E3 ubiquitin-protein ligase BRE1B - Pongo abelii (Sumatran orangutan) - RNF40 gene Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Taurus_UMD|evm.model.AC_000182.1.471 Q9UEG4 ZN629_HUMAN 91.600 0.997699 1 ZNF629 - Zinc finger protein 629 - Homo sapiens (Human) - ZNF629 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.472 Q8WUZ0 BCL7C_HUMAN 73.438 0.984375 0.589862 BCL7C - B-cell CLL/lymphoma 7 protein family member C - Homo sapiens (Human) - BCL7C gene May play an anti-apoptotic role. Taurus_UMD|evm.model.AC_000182.1.473 Q16619 CTF1_HUMAN 81.683 0.990148 1.00995 CTF1 - Cardiotrophin-1 - Homo sapiens (Human) - CTF1 gene Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor. Taurus_UMD|evm.model.AC_000182.1.474 P83714 CTF2_MOUSE 57.542 0.809091 1.07843 Ctf2 - Cardiotrophin-2 precursor - Mus musculus (Mouse) - Ctf2 gene Increases the platelet count associated with splenomegaly. May have an important role in neuronal precursor development and maturation. Taurus_UMD|evm.model.AC_000182.1.476 P83714 CTF2_MOUSE 60.000 0.5 0.627451 Ctf2 - Cardiotrophin-2 precursor - Mus musculus (Mouse) - Ctf2 gene Increases the platelet count associated with splenomegaly. May have an important role in neuronal precursor development and maturation. Taurus_UMD|evm.model.AC_000182.1.477 P83714 CTF2_MOUSE 53.039 0.544025 1.55882 Ctf2 - Cardiotrophin-2 precursor - Mus musculus (Mouse) - Ctf2 gene Increases the platelet count associated with splenomegaly. May have an important role in neuronal precursor development and maturation. Taurus_UMD|evm.model.AC_000182.1.478 Q6PCT2 FXL19_HUMAN 99.853 0.912869 1.07493 FBXL19 - F-box/LRR-repeat protein 19 - Homo sapiens (Human) - FBXL19 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:29276034). Taurus_UMD|evm.model.AC_000182.1.479 Q6AXR8 ORAI3_RAT 89.420 0.993151 1.0069 Orai3 - Protein orai-3 - Rattus norvegicus (Rat) - Orai3 gene Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1. Taurus_UMD|evm.model.AC_000182.1.480 O15047 SET1A_HUMAN 90.217 0.998853 1.02168 SETD1A - Histone-lysine N-methyltransferase SETD1A - Homo sapiens (Human) - SETD1A gene Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression (PubMed:12670868). May play a role in synaptic function and the development of neurons (PubMed:31197650). Taurus_UMD|evm.model.AC_000182.1.481 Q9H2F3 3BHS7_HUMAN 90.217 0.767782 1.29539 HSD3B7 - 3 beta-hydroxysteroid dehydrogenase type 7 - Homo sapiens (Human) - HSD3B7 gene The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. Taurus_UMD|evm.model.AC_000182.1.482 P61268 STX1B_SHEEP 100.000 0.99308 1.00347 STX1B - Syntaxin-1B - Ovis aries (Sheep) - STX1B gene Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity). Taurus_UMD|evm.model.AC_000182.1.483 Q3SWZ3 STX4_BOVIN 100.000 0.993289 1.00337 STX4 - Syntaxin-4 - Bos taurus (Bovine) - STX4 gene Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. May also play a role in docking of synaptic vesicles at presynaptic active zones (By similarity). Taurus_UMD|evm.model.AC_000182.1.485 Q2TA17 ZN668_BOVIN 100.000 0.996774 1.00162 ZNF668 - Zinc finger protein 668 - Bos taurus (Bovine) - ZNF668 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.486 O15015 ZN646_HUMAN 80.076 0.998903 0.995087 ZNF646 - Zinc finger protein 646 - Homo sapiens (Human) - ZNF646 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.487 Q2L4Q9 PRS53_HUMAN 85.099 0.894652 1.11573 PRSS53 - Serine protease 53 precursor - Homo sapiens (Human) - PRSS53 gene In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator. Taurus_UMD|evm.model.AC_000182.1.488 Q6B4J2 VKOR1_BOVIN 100.000 0.987805 1.00613 VKORC1 - Vitamin K epoxide reductase complex subunit 1 - Bos taurus (Bovine) - VKORC1 gene Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development (By similarity). Taurus_UMD|evm.model.AC_000182.1.489 Q2KJG8 BCKD_BOVIN 100.000 0.995157 1.00243 BCKDK - [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor - Bos taurus (Bovine) - BCKDK gene Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. Taurus_UMD|evm.model.AC_000182.1.490 Q9H7Z6 KAT8_HUMAN 99.345 0.995643 1.00218 KAT8 - Histone acetyltransferase KAT8 - Homo sapiens (Human) - KAT8 gene Histone acetyltransferase which may be involved in transcriptional activation (PubMed:12397079, PubMed:22020126). May influence the function of ATM (PubMed:15923642). As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:22020126). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852, PubMed:22547026). That activity is less specific than the one of the MSL complex (PubMed:20018852, PubMed:22547026). Can also acetylate TP53/p53 at 'Lys-120'. Taurus_UMD|evm.model.AC_000182.1.491 Q9ES87 PRSS8_RAT 75.371 0.976744 1.00585 Prss8 - Prostasin precursor - Rattus norvegicus (Rat) - Prss8 gene Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G) (By similarity). Taurus_UMD|evm.model.AC_000182.1.492 Q5K4E3 POLS2_HUMAN 85.137 0.959538 1.0117 PRSS36 - Polyserase-2 precursor - Homo sapiens (Human) - PRSS36 gene Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1. Taurus_UMD|evm.model.AC_000182.1.493 P35637 FUS_HUMAN 100.000 0.513619 0.977186 FUS - RNA-binding protein FUS - Homo sapiens (Human) - FUS gene DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). Taurus_UMD|evm.model.AC_000182.1.494 Q8HXK9 ASC_BOVIN 99.487 0.989796 1.00513 PYCARD - Apoptosis-associated speck-like protein containing a CARD - Bos taurus (Bovine) - PYCARD gene Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Required for recruitment of caspase-1 to inflammasomes containing certain pattern recognition receptors, such as NLRP2, NLRP3, AIM2 and probably IFI16. In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1. In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation. May be involved in DDX58-triggered proinflammatory responses and inflammasome activation. In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8. In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways. For regulation of NF-kappa-B activating and inhibiting functions have been reported. Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK. Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing (By similarity). Modulates host resistance to DNA virus infection, probably by inducing the cleavage of and inactivating CGAS in presence of cytoplasmic double-stranded DNA (By similarity). Taurus_UMD|evm.model.AC_000182.1.495 Q6ZMU5 TRI72_HUMAN 94.715 0.977226 1.01258 TRIM72 - Tripartite motif-containing protein 72 - Homo sapiens (Human) - TRIM72 gene Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity). Taurus_UMD|evm.model.AC_000182.1.496 P11215 ITAM_HUMAN 67.513 0.981018 1.00608 ITGAM - Integrin alpha-M precursor - Homo sapiens (Human) - ITGAM gene Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Taurus_UMD|evm.model.AC_000182.1.497 P20702 ITAX_HUMAN 70.690 0.703704 0.0696475 ITGAX - Integrin alpha-X precursor - Homo sapiens (Human) - ITGAX gene Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Taurus_UMD|evm.model.AC_000182.1.498 Q13349 ITAD_HUMAN 74.935 0.993139 1.00431 ITGAD - Integrin alpha-D precursor - Homo sapiens (Human) - ITGAD gene Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood. Taurus_UMD|evm.model.AC_000182.1.499 P07471 CX6A2_BOVIN 100.000 0.979592 1.01031 COX6A2 - Cytochrome c oxidase subunit 6A2, mitochondrial precursor - Bos taurus (Bovine) - COX6A2 gene Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Plays a role in the assembly and stabilization of complex IV (By similarity). Taurus_UMD|evm.model.AC_000182.1.500 Q5R5U3 ZN271_PONAB 49.000 0.640523 0.227679 ZNF271 - Zinc finger protein 271 - Pongo abelii (Sumatran orangutan) - ZNF271 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.501 Q96C12 ARMC5_HUMAN 87.898 0.461538 1.08449 ARMC5 - Armadillo repeat-containing protein 5 - Homo sapiens (Human) - ARMC5 gene Involved in fetal development, T-cell function and adrenal gland growth homeostasis (By similarity). Negatively regulates adrenal cells survival. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429). Taurus_UMD|evm.model.AC_000182.1.502 Q3MHZ4 TGFI1_BOVIN 100.000 0.995624 1.00219 TGFB1I1 - Transforming growth factor beta-1-induced transcript 1 protein - Bos taurus (Bovine) - TGFB1I1 gene Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. Taurus_UMD|evm.model.AC_000182.1.503 P31639 SC5A2_HUMAN 91.679 0.997033 1.00298 SLC5A2 - Sodium/glucose cotransporter 2 - Homo sapiens (Human) - SLC5A2 gene Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Taurus_UMD|evm.model.AC_000182.1.504 Q5R8F6 RUSF1_PONAB 83.843 0.987041 0.989316 Rusf1 - RUS family member 1 - Pongo abelii (Sumatran orangutan) - Rusf1 gene Taurus_UMD|evm.model.AC_000182.1.505 Q865F8 AHSP_BOVIN 86.420 0.629921 1.38043 AHSP - Alpha-hemoglobin-stabilizing protein - Bos taurus (Bovine) - AHSP gene Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation (By similarity). Taurus_UMD|evm.model.AC_000182.1.506 A6QQL3 SEP14_BOVIN 99.769 0.850099 1.17361 SEPTIN14 - Septin-14 - Bos taurus (Bovine) - SEPTIN14 gene Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Taurus_UMD|evm.model.AC_000182.1.507 Q8N859 ZN713_HUMAN 86.449 0.946548 1.04419 ZNF713 - Zinc finger protein 713 - Homo sapiens (Human) - ZNF713 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.508 P82916 RT17_BOVIN 100.000 0.984733 1.00769 MRPS17 - 28S ribosomal protein S17, mitochondrial - Bos taurus (Bovine) - MRPS17 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit Taurus_UMD|evm.model.AC_000182.1.509 O75323 NIPS2_HUMAN 92.308 0.993031 1.0035 NIPSNAP2 - Protein NipSnap homolog 2 - Homo sapiens (Human) - NIPSNAP2 gene May act as a positive regulator of L-type calcium channels. Taurus_UMD|evm.model.AC_000182.1.510 Q2KHU0 SERB_BOVIN 100.000 0.99115 1.00444 PSPH - Phosphoserine phosphatase - Bos taurus (Bovine) - PSPH gene Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine. L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator. May also act on O-phospho-D-serine. Taurus_UMD|evm.model.AC_000182.1.511 Q3MHL7 TCPZ_BOVIN 86.064 0.995992 0.939736 CCT6A - T-complex protein 1 subunit zeta - Bos taurus (Bovine) - CCT6A gene Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin. Taurus_UMD|evm.model.AC_000182.1.512 Q58CP2 SUMF2_BOVIN 100.000 0.993377 1.00332 SUMF2 - Inactive C-alpha-formylglycine-generating enzyme 2 precursor - Bos taurus (Bovine) - SUMF2 gene Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Taurus_UMD|evm.model.AC_000182.1.513 P07934 PHKG1_MOUSE 94.560 0.992268 1 Phkg1 - Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform - Mus musculus (Mouse) - Phkg1 gene Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). Taurus_UMD|evm.model.AC_000182.1.514 Q9Y6H1 CHCH2_HUMAN 90.850 0.987013 1.01987 CHCHD2 - Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 - Homo sapiens (Human) - CHCHD2 gene Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). Taurus_UMD|evm.model.AC_000182.1.515 Q32PB4 NUPR2_BOVIN 97.959 0.979798 1.0102 NUPR2 - Nuclear protein 2 - Bos taurus (Bovine) - NUPR2 gene Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells. Involved in the G1 cell cycle arrest, and in a decrease in cell viability and cell proliferation. Plays a role as a negative regulator of the protumoral factor NUPR1. Taurus_UMD|evm.model.AC_000182.1.516 Q15370 ELOB_HUMAN 84.746 0.983193 1.00847 ELOB - Elongin-B - Homo sapiens (Human) - ELOB gene SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). Taurus_UMD|evm.model.AC_000182.1.517 Q8N0U8 VKORL_HUMAN 95.385 0.52459 0.693182 VKORC1L1 - Vitamin K epoxide reductase complex subunit 1-like protein 1 - Homo sapiens (Human) - VKORC1L1 gene Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins. Taurus_UMD|evm.model.AC_000182.1.519 Q4FAT7 BGLR_PIG 88.344 0.996937 1.00153 GUSB - Beta-glucuronidase precursor - Sus scrofa (Pig) - GUSB gene Plays an important role in the degradation of dermatan and keratan sulfates. Taurus_UMD|evm.model.AC_000182.1.520 O97524 BGLR_FELCA 79.123 0.990909 0.675883 GUSB - Beta-glucuronidase precursor - Felis catus (Cat) - GUSB gene Plays an important role in the degradation of dermatan and keratan sulfates. Taurus_UMD|evm.model.AC_000182.1.521 Q3SZJ0 ARLY_BOVIN 99.789 0.995781 1.00211 ASL - Argininosuccinate lyase - Bos taurus (Bovine) - ASL gene cytosol, argininosuccinate lyase activity, arginine biosynthetic process via ornithine Taurus_UMD|evm.model.AC_000182.1.522 A0JN61 RPC9_BOVIN 100.000 0.686916 1.44595 CRCP - DNA-directed RNA polymerase III subunit RPC9 - Bos taurus (Bovine) - CRCP gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Taurus_UMD|evm.model.AC_000182.1.523 O60507 TPST1_HUMAN 96.757 0.994609 1.0027 TPST1 - Protein-tyrosine sulfotransferase 1 - Homo sapiens (Human) - TPST1 gene Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. Taurus_UMD|evm.model.AC_000182.1.524 A4IFB4 KCTD7_BOVIN 93.015 0.992366 0.906574 KCTD7 - BTB/POZ domain-containing protein KCTD7 - Bos taurus (Bovine) - KCTD7 gene May be involved in the control of excitability of cortical neurons. Taurus_UMD|evm.model.AC_000182.1.525 O18973 RABX5_BOVIN 100.000 0.995943 1.00203 RABGEF1 - Rab5 GDP/GTP exchange factor - Bos taurus (Bovine) - RABGEF1 gene Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. Taurus_UMD|evm.model.AC_000182.1.527 Q2YDM0 TM248_BOVIN 100.000 0.993651 1.00318 TMEM248 - Transmembrane protein 248 - Bos taurus (Bovine) - TMEM248 gene Taurus_UMD|evm.model.AC_000182.1.528 Q3SWZ6 SBDS_BOVIN 100.000 0.992032 1.004 SBDS - Ribosome maturation protein SBDS - Bos taurus (Bovine) - SBDS gene Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000182.1.529 Q5REF9 TYW1_PONAB 78.552 0.997041 0.923497 TYW1 - S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 - Pongo abelii (Sumatran orangutan) - TYW1 gene Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity). Taurus_UMD|evm.model.AC_000182.1.530 Q9BXU9 CABP8_HUMAN 100.000 0.990909 0.842912 CALN1 - Calcium-binding protein 8 - Homo sapiens (Human) - CALN1 gene Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning. Taurus_UMD|evm.model.AC_000182.1.532 Q6IS24 GLT17_HUMAN 98.649 0.996146 0.867893 GALNT17 - Polypeptide N-acetylgalactosaminyltransferase 17 - Homo sapiens (Human) - GALNT17 gene May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Taurus_UMD|evm.model.AC_000182.1.533 Q6IS24 GLT17_HUMAN 92.405 0.329114 0.396321 GALNT17 - Polypeptide N-acetylgalactosaminyltransferase 17 - Homo sapiens (Human) - GALNT17 gene May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Taurus_UMD|evm.model.AC_000182.1.535 Q8WXX7 AUTS2_HUMAN 90.571 0.929078 0.895949 AUTS2 - Autism susceptibility gene 2 protein - Homo sapiens (Human) - AUTS2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). Taurus_UMD|evm.model.AC_000182.1.536 Q8WXX7 AUTS2_HUMAN 99.091 0.995455 0.174742 AUTS2 - Autism susceptibility gene 2 protein - Homo sapiens (Human) - AUTS2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). Taurus_UMD|evm.model.AC_000182.1.542 A6NHX0 CAST2_HUMAN 98.480 0.993939 1.00304 CASTOR2 - Cytosolic arginine sensor for mTORC1 subunit 2 - Homo sapiens (Human) - CASTOR2 gene Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. Taurus_UMD|evm.model.AC_000182.1.543 Q96I51 RCC1L_HUMAN 92.241 0.995699 1.00216 RCC1L - RCC1-like G exchanging factor-like protein precursor - Homo sapiens (Human) - RCC1L gene Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion (PubMed:28746876). Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system (PubMed:27667664). Taurus_UMD|evm.model.AC_000182.1.544 A4IFA3 GT2D2_BOVIN 99.895 0.997897 1.00105 GTF2IRD2 - General transcription factor II-I repeat domain-containing protein 2 - Bos taurus (Bovine) - GTF2IRD2 gene nucleus Taurus_UMD|evm.model.AC_000182.1.545 O77774 NCF1_BOVIN 100.000 0.994911 1.00255 NCF1 - Neutrophil cytosol factor 1 - Bos taurus (Bovine) - NCF1 gene NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Taurus_UMD|evm.model.AC_000182.1.546 A7MB80 GTF2I_BOVIN 97.955 0.941003 1.03988 GTF2I - General transcription factor II-I - Bos taurus (Bovine) - GTF2I gene Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation (By similarity). Taurus_UMD|evm.model.AC_000182.1.549 Q9UHL9 GT2D1_HUMAN 93.438 0.997886 0.986444 GTF2IRD1 - General transcription factor II-I repeat domain-containing protein 1 - Homo sapiens (Human) - GTF2IRD1 gene May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). Taurus_UMD|evm.model.AC_000182.1.550 Q9UDT6 CLIP2_HUMAN 92.850 0.968519 1.0325 CLIP2 - CAP-Gly domain-containing linker protein 2 - Homo sapiens (Human) - CLIP2 gene Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). Taurus_UMD|evm.model.AC_000182.1.551 Q05B83 RFC2_BOVIN 100.000 0.994334 1.00284 RFC2 - Replication factor C subunit 2 - Bos taurus (Bovine) - RFC2 gene The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). Taurus_UMD|evm.model.AC_000182.1.552 Q9JHL0 NTAL_MOUSE 62.559 0.976303 1.03941 Lat2 - Linker for activation of T-cells family member 2 - Mus musculus (Mouse) - Lat2 gene Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. Taurus_UMD|evm.model.AC_000182.1.553 Q1JPH6 IF4H_BOVIN 100.000 0.991266 1.00439 EIF4H - Eukaryotic translation initiation factor 4H - Bos taurus (Bovine) - EIF4H gene Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity). Taurus_UMD|evm.model.AC_000182.1.554 P53667 LIMK1_HUMAN 97.682 0.996914 1.00155 LIMK1 - LIM domain kinase 1 - Homo sapiens (Human) - LIMK1 gene Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). Taurus_UMD|evm.model.AC_000182.1.555 P04985 ELN_BOVIN 94.891 0.178478 1.02008 ELN - Elastin precursor - Bos taurus (Bovine) - ELN gene Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). Taurus_UMD|evm.model.AC_000182.1.557 Q2TBQ4 TM270_BOVIN 99.618 0.992395 1.00382 TMEM270 - Transmembrane protein 270 - Bos taurus (Bovine) - TMEM270 gene Taurus_UMD|evm.model.AC_000182.1.558 Q8N6F8 MET27_HUMAN 80.288 0.841463 1.00408 METTL27 - Methyltransferase-like protein 27 - Homo sapiens (Human) - METTL27 gene methyltransferase activity Taurus_UMD|evm.model.AC_000182.1.559 Q6BBL6 CLD4_BOVIN 100.000 0.990476 1.00478 CLDN4 - Claudin-4 - Bos taurus (Bovine) - CLDN4 gene Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Taurus_UMD|evm.model.AC_000182.1.560 Q765N9 CLD3_BOVIN 100.000 0.990909 1.00457 CLDN3 - Claudin-3 - Bos taurus (Bovine) - CLDN3 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Taurus_UMD|evm.model.AC_000182.1.561 Q3SZ73 ABHDB_BOVIN 100.000 0.993421 1.0033 ABHD11 - Protein ABHD11 - Bos taurus (Bovine) - ABHD11 gene mitochondrion Taurus_UMD|evm.model.AC_000182.1.562 Q0V9T6 BICL1_XENTR 40.506 0.509804 0.255426 bicdl1 - BICD family-like cargo adapter 1 - Xenopus tropicalis (Western clawed frog) - bicdl1 gene Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Taurus_UMD|evm.model.AC_000182.1.563 P32850 STX1A_BOVIN 100.000 0.99308 1.00347 STX1A - Syntaxin-1A - Bos taurus (Bovine) - STX1A gene Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion (By similarity). Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm. Plays also an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity). Taurus_UMD|evm.model.AC_000182.1.564 Q58DP0 BUD23_BOVIN 100.000 0.992908 1.00356 BUD23 - Probable 18S rRNA (guanine-N(7))-methyltransferase - Bos taurus (Bovine) - BUD23 gene S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro. Taurus_UMD|evm.model.AC_000182.1.565 Q96LL9 DJC30_HUMAN 78.571 0.920705 1.00442 DNAJC30 - DnaJ homolog subfamily C member 30, mitochondrial precursor - Homo sapiens (Human) - DNAJC30 gene Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthase complex and facilitates ATP synthesis (By similarity). Taurus_UMD|evm.model.AC_000182.1.566 Q86XT2 VP37D_HUMAN 97.156 0.990566 0.844622 VPS37D - Vacuolar protein sorting-associated protein 37D - Homo sapiens (Human) - VPS37D gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Taurus_UMD|evm.model.AC_000182.1.567 Q9NP71 MLXPL_HUMAN 85.325 0.98133 1.00587 MLXIPL - Carbohydrate-responsive element-binding protein - Homo sapiens (Human) - MLXIPL gene Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity). Taurus_UMD|evm.model.AC_000182.1.568 Q9Y4P3 TBL2_HUMAN 89.038 0.995526 1 TBL2 - Transducin beta-like protein 2 - Homo sapiens (Human) - TBL2 gene endoplasmic reticulum, integral component of endoplasmic reticulum membrane, phosphoprotein binding, protein kinase binding, RNA binding, translation initiation factor binding, cellular response to glucose starvation, cellular response to hypoxia, endoplasmic reticulum unfolded protein response Taurus_UMD|evm.model.AC_000182.1.569 Q3T0A6 BCL7B_BOVIN 100.000 0.990148 1.00495 BCL7B - B-cell CLL/lymphoma 7 protein family member B - Bos taurus (Bovine) - BCL7B gene Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1. Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation. May play a role in lung tumor development or progression. Taurus_UMD|evm.model.AC_000182.1.570 Q9UIG0 BAZ1B_HUMAN 94.673 0.998651 1 BAZ1B - Tyrosine-protein kinase BAZ1B - Homo sapiens (Human) - BAZ1B gene Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. Taurus_UMD|evm.model.AC_000182.1.571 O00144 FZD9_HUMAN 95.770 0.99661 0.998308 FZD9 - Frizzled-9 precursor - Homo sapiens (Human) - FZD9 gene Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity). Taurus_UMD|evm.model.AC_000182.1.572 A6QQ71 FKBP6_BOVIN 96.308 0.987805 1.00613 FKBP6 - Inactive peptidyl-prolyl cis-trans isomerase FKBP6 - Bos taurus (Bovine) - FKBP6 gene Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity). Taurus_UMD|evm.model.AC_000182.1.573 Q865W2 TRI50_PIG 93.429 0.995902 1.00412 TRIM50 - E3 ubiquitin-protein ligase TRIM50 - Sus scrofa (Pig) - TRIM50 gene E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction. Taurus_UMD|evm.model.AC_000182.1.574 Q96P11 NSUN5_HUMAN 87.681 0.892009 1.07925 NSUN5 - 28S rRNA (cytosine-C(5))-methyltransferase - Homo sapiens (Human) - NSUN5 gene S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA (PubMed:23913415, PubMed:31428936, PubMed:31722427). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (PubMed:31428936, PubMed:31722427). Required for corpus callosum and cerebral cortex development (By similarity). Taurus_UMD|evm.model.AC_000182.1.575 Q6PJE2 POZP3_HUMAN 76.000 0.0599836 6.50802 POMZP3 - POM121 and ZP3 fusion protein - Homo sapiens (Human) - POMZP3 gene extracellular matrix, nuclear membrane, nucleoplasm, acrosin binding, binding of sperm to zona pellucida, egg coat formation, positive regulation of acrosome reaction Taurus_UMD|evm.model.AC_000182.1.576 O00291 HIP1_HUMAN 86.187 0.99811 1.02025 HIP1 - Huntingtin-interacting protein 1 - Homo sapiens (Human) - HIP1 gene Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). Taurus_UMD|evm.model.AC_000182.1.577 Q64H35 CCL26_CANLF 69.892 0.968421 1.01064 CCL26 - C-C motif chemokine 26 precursor - Canis lupus familiaris (Dog) - CCL26 gene Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils. Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing cell chemotaxis. Taurus_UMD|evm.model.AC_000182.1.578 P79251 VATG1_BOVIN 71.429 0.837838 0.627119 ATP6V1G1 - V-type proton ATPase subunit G 1 - Bos taurus (Bovine) - ATP6V1G1 gene Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). Taurus_UMD|evm.model.AC_000182.1.579 Q68Y86 CCL24_CANLF 60.504 0.982906 0.983193 CCL24 - C-C motif chemokine 24 precursor - Canis lupus familiaris (Dog) - CCL24 gene Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3. Taurus_UMD|evm.model.AC_000182.1.580 Q6NTF9 RHBD2_HUMAN 85.675 0.991781 1.00275 RHBDD2 - Rhomboid domain-containing protein 2 - Homo sapiens (Human) - RHBDD2 gene Golgi apparatus, Hrd1p ubiquitin ligase ERAD-L complex, integral component of endoplasmic reticulum membrane, nucleoplasm, misfolded protein binding, ubiquitin-specific protease binding, endoplasmic reticulum unfolded protein response, ubiquitin-dependent ERAD pathway Taurus_UMD|evm.model.AC_000182.1.581 Q9GMB0 RPN1_PIG 91.429 0.954128 0.179276 RPN1 - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor - Sus scrofa (Pig) - RPN1 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (Probable). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Taurus_UMD|evm.model.AC_000182.1.582 Q3SYT8 NCPR_BOVIN 100.000 0.994126 1.00442 POR - NADPH--cytochrome P450 reductase - Bos taurus (Bovine) - POR gene This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Taurus_UMD|evm.model.AC_000182.1.583 Q05B45 TACAN_BOVIN 100.000 0.994186 1.00292 TMEM120A - Ion channel TACAN - Bos taurus (Bovine) - TMEM120A gene Ion channel involved in sensing mechanical pain. Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli. May also be required for efficient adipogenesis. Taurus_UMD|evm.model.AC_000182.1.584 Q9Y6J8 STYL1_HUMAN 72.401 0.925676 0.945687 STYXL1 - Serine/threonine/tyrosine-interacting-like protein 1 - Homo sapiens (Human) - STYXL1 gene Catalytically inactive phosphatase (PubMed:20180778, PubMed:23163895). By binding to G3BP1, inhibits the formation of G3BP1-induced stress granules (PubMed:20180778, PubMed:23163895). Does not act by protecting the dephosphorylation of G3BP1 at 'Ser-149' (PubMed:23163895). Inhibits PTPMT1 phosphatase activity (PubMed:24709986). By inhibiting PTPMT1, positively regulates intrinsic apoptosis (PubMed:21262771). May play a role in the formation of neurites during neuronal development (PubMed:29250526). Taurus_UMD|evm.model.AC_000182.1.585 Q32LG3 MDHM_BOVIN 100.000 0.9941 1.00296 MDH2 - Malate dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - MDH2 gene cytoplasm, mitochondrial matrix, mitochondrion, L-malate dehydrogenase activity, protein homodimerization activity, aerobic respiration, tricarboxylic acid cycle Taurus_UMD|evm.model.AC_000182.1.586 A6NNA2 SRRM3_HUMAN 91.265 0.521669 1.04355 SRRM3 - Serine/arginine repetitive matrix protein 3 - Homo sapiens (Human) - SRRM3 gene May play a role in regulating breast cancer cell invasiveness (PubMed:26053433). May be involved in RYBP-mediated breast cancer progression (PubMed:27748911). Taurus_UMD|evm.model.AC_000182.1.587 Q3T149 HSPB1_BOVIN 100.000 0.990099 1.00498 HSPB1 - Heat shock protein beta-1 - Bos taurus (Bovine) - HSPB1 gene Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. Taurus_UMD|evm.model.AC_000182.1.588 P61983 1433G_RAT 100.000 0.991935 1.00405 Ywhag - 14-3-3 protein gamma - Rattus norvegicus (Rat) - Ywhag gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Taurus_UMD|evm.model.AC_000182.1.589 Q8WTU2 SRB4D_HUMAN 90.609 0.97774 1.01565 SSC4D - Scavenger receptor cysteine-rich domain-containing group B protein precursor - Homo sapiens (Human) - SSC4D gene Taurus_UMD|evm.model.AC_000182.1.590 P48830 ZP3_BOVIN 99.762 0.995261 1.00238 ZP3 - Zona pellucida sperm-binding protein 3 precursor - Bos taurus (Bovine) - ZP3 gene Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. Taurus_UMD|evm.model.AC_000182.1.591 Q86UW9 DTX2_HUMAN 90.514 0.996774 0.996785 DTX2 - Probable E3 ubiquitin-protein ligase DTX2 - Homo sapiens (Human) - DTX2 gene Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Taurus_UMD|evm.model.AC_000182.1.592 Q864V4 UPK3B_BOVIN 100.000 0.992857 1.00358 UPK3B - Uroplakin-3b precursor - Bos taurus (Bovine) - UPK3B gene Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). Taurus_UMD|evm.model.AC_000182.1.593 A6QQ85 UPK3L_BOVIN 99.605 0.919708 1.083 UPK3BL1 - Uroplakin-3b-like protein 1 precursor - Bos taurus (Bovine) - UPK3BL1 gene integral component of membrane Taurus_UMD|evm.model.AC_000182.1.594 O43374 RASL2_HUMAN 90.294 0.984868 0.987547 RASA4 - Ras GTPase-activating protein 4 - Homo sapiens (Human) - RASA4 gene Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. Taurus_UMD|evm.model.AC_000182.1.595 P52435 RPB11_HUMAN 100.000 0.983051 1.00855 POLR2J - DNA-directed RNA polymerase II subunit RPB11-a - Homo sapiens (Human) - POLR2J gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). Taurus_UMD|evm.model.AC_000182.1.596 Q9UFC0 LRWD1_HUMAN 79.199 0.992272 1 LRWD1 - Leucine-rich repeat and WD repeat-containing protein 1 - Homo sapiens (Human) - LRWD1 gene Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. Taurus_UMD|evm.model.AC_000182.1.597 Q9NXW9 ALKB4_HUMAN 85.762 0.990132 1.00662 ALKBH4 - Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 - Homo sapiens (Human) - ALKBH4 gene Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (PubMed:23673617). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity). Taurus_UMD|evm.model.AC_000182.1.598 Q96SN7 ORAI2_HUMAN 97.638 0.992157 1.00394 ORAI2 - Protein orai-2 - Homo sapiens (Human) - ORAI2 gene Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1. Taurus_UMD|evm.model.AC_000182.1.599 P0AEJ0 EMRB_ECOLI 53.226 0.512605 0.232422 emrB - Multidrug export protein EmrB - Escherichia coli (strain K12) - emrB gene Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4-dinitrophenol and nalidixic acid. Taurus_UMD|evm.model.AC_000182.1.600 Q2KIT1 PKRI1_BOVIN 98.925 0.989305 1.00538 PRKRIP1 - PRKR-interacting protein 1 - Bos taurus (Bovine) - PRKRIP1 gene Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity). Taurus_UMD|evm.model.AC_000182.1.601 P62315 SMD1_MOUSE 97.321 0.982301 0.94958 Snrpd1 - Small nuclear ribonucleoprotein Sm D1 - Mus musculus (Mouse) - Snrpd1 gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. Taurus_UMD|evm.model.AC_000182.1.602 O14492 SH2B2_HUMAN 86.548 0.938367 1.0269 SH2B2 - SH2B adapter protein 2 - Homo sapiens (Human) - SH2B2 gene Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. Taurus_UMD|evm.model.AC_000182.1.603 Q5R8V1 CASP_PONAB 93.077 0.973585 0.390855 CUTL1 - Protein CASP - Pongo abelii (Sumatran orangutan) - CUTL1 gene May be involved in intra-Golgi retrograde transport. Taurus_UMD|evm.model.AC_000182.1.604 Q5R8V1 CASP_PONAB 97.990 0.256626 2.28171 CUTL1 - Protein CASP - Pongo abelii (Sumatran orangutan) - CUTL1 gene May be involved in intra-Golgi retrograde transport. Taurus_UMD|evm.model.AC_000182.1.605 Q62082 MYL10_MOUSE 91.156 0.80663 0.89604 Myl10 - Myosin regulatory light chain 10 - Mus musculus (Mouse) - Myl10 gene mitochondrion Taurus_UMD|evm.model.AC_000182.1.606 Q96A83 COQA1_HUMAN 89.116 0.72351 1.36961 COL26A1 - Collagen alpha-1(XXVI) chain precursor - Homo sapiens (Human) - COL26A1 gene collagen-containing extracellular matrix, endoplasmic reticulum lumen, extracellular region, plasma membrane, collagen fibril organization Taurus_UMD|evm.model.AC_000182.1.607 Q5E9J4 IFT22_BOVIN 99.459 0.989247 1.00541 IFT22 - Intraflagellar transport protein 22 homolog - Bos taurus (Bovine) - IFT22 gene Small GTPase-like component of the intraflagellar transport (IFT) complex B. Taurus_UMD|evm.model.AC_000182.1.608 Q3T0I5 FIS1_BOVIN 100.000 0.986928 1.00658 FIS1 - Mitochondrial fission 1 protein - Bos taurus (Bovine) - FIS1 gene Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (By similarity). Taurus_UMD|evm.model.AC_000182.1.609 Q2KIY2 CLD15_BOVIN 99.574 0.991525 1.00426 CLDN15 - Claudin-15 - Bos taurus (Bovine) - CLDN15 gene Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake (By similarity). Taurus_UMD|evm.model.AC_000182.1.610 O43257 ZNHI1_HUMAN 100.000 0.987097 1.00649 ZNHIT1 - Zinc finger HIT domain-containing protein 1 - Homo sapiens (Human) - ZNHIT1 gene Seems to play a role in p53-mediated apoptosis induction (PubMed:17380123). Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity (PubMed:17892483). Taurus_UMD|evm.model.AC_000182.1.611 Q5R6K5 PLOD3_PONAB 94.986 0.953457 1.01897 PLOD3 - Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor - Pongo abelii (Sumatran orangutan) - PLOD3 gene Multifunctional enzyme that catalyzes a series of post-translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the ADIPOQ collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Essential for normal biosynthesis and secretion of type IV collagens. Essential for normal formation of basement membranes (By similarity). Taurus_UMD|evm.model.AC_000182.1.612 Q86VF5 MOGT3_HUMAN 72.131 0.967742 0.181818 MOGAT3 - 2-acylglycerol O-acyltransferase 3 - Homo sapiens (Human) - MOGAT3 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). Taurus_UMD|evm.model.AC_000182.1.613 Q86VF5 MOGT3_HUMAN 73.780 0.990909 0.967742 MOGAT3 - 2-acylglycerol O-acyltransferase 3 - Homo sapiens (Human) - MOGAT3 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). Taurus_UMD|evm.model.AC_000182.1.614 Q86VF5 MOGT3_HUMAN 63.158 0.0225972 9.73314 MOGAT3 - 2-acylglycerol O-acyltransferase 3 - Homo sapiens (Human) - MOGAT3 gene Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). Taurus_UMD|evm.model.AC_000182.1.615 P86435 VGF_BOVIN 100.000 0.933025 0.700647 VGF - Neurosecretory protein VGF precursor - Bos taurus (Bovine) - VGF gene Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity). Taurus_UMD|evm.model.AC_000182.1.616 P61967 AP1S1_MOUSE 100.000 0.987342 1 Ap1s1 - AP-1 complex subunit sigma-1A - Mus musculus (Mouse) - Ap1s1 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Taurus_UMD|evm.model.AC_000182.1.617 P13909 PAI1_BOVIN 100.000 0.783203 1.27363 SERPINE1 - Plasminogen activator inhibitor 1 precursor - Bos taurus (Bovine) - SERPINE1 gene Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity). Taurus_UMD|evm.model.AC_000182.1.618 E1BD59 TRI56_BOVIN 96.821 0.997354 1.03279 TRIM56 - E3 ubiquitin-protein ligase TRIM56 - Bos taurus (Bovine) - TRIM56 gene E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (By similarity). Restricts bovine viral diarrhea virus (BVDV) replication (PubMed:21289118). Taurus_UMD|evm.model.AC_000182.1.619 Q9UKN1 MUC12_HUMAN 60.435 0.791667 0.0525739 MUC12 - Mucin-12 precursor - Homo sapiens (Human) - MUC12 gene Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium. Taurus_UMD|evm.model.AC_000182.1.621 P23795 ACES_BOVIN 99.837 0.996743 1.00163 ACHE - Acetylcholinesterase precursor - Bos taurus (Bovine) - ACHE gene Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Taurus_UMD|evm.model.AC_000182.1.622 Q6NVU6 UFSP1_HUMAN 86.620 0.555118 1.78873 UFSP1 - Inactive Ufm1-specific protease 1 - Homo sapiens (Human) - UFSP1 gene Taurus_UMD|evm.model.AC_000182.1.623 Q3SX26 TRIP6_BOVIN 99.777 0.331606 2.80873 TRIP6 - Thyroid receptor-interacting protein 6 - Bos taurus (Bovine) - TRIP6 gene Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor (By similarity). Taurus_UMD|evm.model.AC_000182.1.624 Q9BXP2 S12A9_HUMAN 93.107 0.997814 1.00109 SLC12A9 - Solute carrier family 12 member 9 - Homo sapiens (Human) - SLC12A9 gene May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function. Taurus_UMD|evm.model.AC_000182.1.625 P54760 EPHB4_HUMAN 96.049 0.997976 1.00101 EPHB4 - Ephrin type-B receptor 4 precursor - Homo sapiens (Human) - EPHB4 gene Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. Taurus_UMD|evm.model.AC_000182.1.626 P48617 EPO_BOVIN 100.000 0.047619 15.2031 EPO - Erythropoietin precursor - Bos taurus (Bovine) - EPO gene Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Taurus_UMD|evm.model.AC_000182.1.627 Q0II25 POP7_BOVIN 100.000 0.985816 1.00714 POP7 - Ribonuclease P protein subunit p20 - Bos taurus (Bovine) - POP7 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Taurus_UMD|evm.model.AC_000182.1.629 O75420 GGYF1_HUMAN 91.475 0.998071 1.00193 GIGYF1 - GRB10-interacting GYF protein 1 - Homo sapiens (Human) - GIGYF1 gene May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). Taurus_UMD|evm.model.AC_000182.1.630 P54313 GBB2_RAT 100.000 0.994135 1.00294 Gnb2 - Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 - Rattus norvegicus (Rat) - Gnb2 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Taurus_UMD|evm.model.AC_000182.1.631 P86173 ACL6B_RAT 100.000 0.995316 1.00235 Actl6b - Actin-like protein 6B - Rattus norvegicus (Rat) - Actl6b gene Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth. Essential for neuronal maturation and dendrite development (By similarity). Taurus_UMD|evm.model.AC_000182.1.632 Q9UP52 TFR2_HUMAN 86.476 0.997512 1.00375 TFR2 - Transferrin receptor protein 2 - Homo sapiens (Human) - TFR2 gene Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Taurus_UMD|evm.model.AC_000182.1.633 Q3T033 MSPD3_BOVIN 100.000 0.991525 1.00426 MOSPD3 - Motile sperm domain-containing protein 3 - Bos taurus (Bovine) - MOSPD3 gene endoplasmic reticulum membrane, plasma membrane, FFAT motif binding, endoplasmic reticulum membrane organization, endoplasmic reticulum-plasma membrane tethering Taurus_UMD|evm.model.AC_000182.1.634 Q15113 PCOC1_HUMAN 83.223 0.995575 1.00668 PCOLCE - Procollagen C-endopeptidase enhancer 1 precursor - Homo sapiens (Human) - PCOLCE gene Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. Taurus_UMD|evm.model.AC_000182.1.635 Q4R327 FBX24_MACFA 89.810 0.974705 1.02241 FBXO24 - F-box only protein 24 - Macaca fascicularis (Crab-eating macaque) - FBXO24 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000182.1.636 O75427 LRCH4_HUMAN 86.688 0.931715 0.964861 LRCH4 - Leucine-rich repeat and calponin homology domain-containing protein 4 - Homo sapiens (Human) - LRCH4 gene PML body, nervous system development Taurus_UMD|evm.model.AC_000182.1.637 Q8TEE9 SAP25_HUMAN 65.686 0.667785 1.49749 SAP25 - Histone deacetylase complex subunit SAP25 - Homo sapiens (Human) - SAP25 gene Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex. Taurus_UMD|evm.model.AC_000182.1.638 Q6P4Y6 IRS1_XENTR 50.633 0.429644 0.814985 irs1 - Insulin receptor substrate 1 - Xenopus tropicalis (Western clawed frog) - irs1 gene May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or grb2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). Taurus_UMD|evm.model.AC_000182.1.639 O95081 AGFG2_HUMAN 86.469 0.962887 1.00832 AGFG2 - Arf-GAP domain and FG repeat-containing protein 2 - Homo sapiens (Human) - AGFG2 gene membrane Taurus_UMD|evm.model.AC_000182.1.640 Q6ZVC0 NYAP1_HUMAN 92.571 0.997636 1.00595 NYAP1 - Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 - Homo sapiens (Human) - NYAP1 gene Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. Taurus_UMD|evm.model.AC_000182.1.642 Q3B8N7 T22D4_RAT 83.855 0.995192 1.07494 Tsc22d4 - TSC22 domain family protein 4 - Rattus norvegicus (Rat) - Tsc22d4 gene Transcriptional repressor. Taurus_UMD|evm.model.AC_000182.1.643 Q2T9X5 CG061_BOVIN 99.510 0.990244 1.0049 Uncharacterized protein C7orf61 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000182.1.644 A6QPM6 PPR35_BOVIN 100.000 0.992509 1.00376 PPP1R35 - Protein phosphatase 1 regulatory subunit 35 - Bos taurus (Bovine) - PPP1R35 gene Inhibits PPP1CA phosphatase activity. Taurus_UMD|evm.model.AC_000182.1.645 Q7L2J0 MEPCE_HUMAN 90.290 0.997093 0.998549 MEPCE - 7SK snRNA methylphosphate capping enzyme - Homo sapiens (Human) - MEPCE gene S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Taurus_UMD|evm.model.AC_000182.1.646 Q9H0M4 ZCPW1_HUMAN 66.974 0.984496 0.99537 ZCWPW1 - Zinc finger CW-type PWWP domain protein 1 - Homo sapiens (Human) - ZCWPW1 gene Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3) (PubMed:32744506, PubMed:20826339). Facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs) (By similarity). Essential for male fertility and spermatogenesis (By similarity). Required for meiosis prophase I progression in male but not in female germ cells (By similarity). Taurus_UMD|evm.model.AC_000182.1.647 Q9UKJ1 PILRA_HUMAN 50.181 0.893333 0.990099 PILRA - Paired immunoglobulin-like type 2 receptor alpha precursor - Homo sapiens (Human) - PILRA gene Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. Taurus_UMD|evm.model.AC_000182.1.648 Q6DKI7 PVRIG_HUMAN 59.677 0.980707 0.953988 PVRIG - Transmembrane protein PVRIG - Homo sapiens (Human) - PVRIG gene Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. Taurus_UMD|evm.model.AC_000182.1.649 Q9UJ98 STAG3_HUMAN 85.493 0.982272 1.01306 STAG3 - Cohesin subunit SA-3 - Homo sapiens (Human) - STAG3 gene Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. Taurus_UMD|evm.model.AC_000182.1.650 Q8N158 GPC2_HUMAN 74.956 0.965458 1 GPC2 - Glypican-2 precursor - Homo sapiens (Human) - GPC2 gene Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity). Taurus_UMD|evm.model.AC_000182.1.651 Q5E9W5 G3ST4_BOVIN 99.793 0.995868 1.00207 GAL3ST4 - Galactose-3-O-sulfotransferase 4 - Bos taurus (Bovine) - GAL3ST4 gene Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc (By similarity). Taurus_UMD|evm.model.AC_000182.1.652 Q8WVR3 TPC14_HUMAN 97.759 0.996558 1.00172 TRAPPC14 - Trafficking protein particle complex subunit 14 - Homo sapiens (Human) - TRAPPC14 gene Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether (PubMed:31467083, PubMed:30715179). TRAPP II complex has also GEF activity toward RAB1A (By similarity). TRAPPC14 is dispensable for TRAPPII complex integrity but mediates RAB3IP preciliary vesicle trafficking to the mother centriole during ciliogenesis (PubMed:31467083). Modulates YAP1 activity as transcriptional regulator (PubMed:30447097). Taurus_UMD|evm.model.AC_000182.1.653 Q2M2U3 LTOR4_BOVIN 100.000 0.98 1.0101 LAMTOR4 - Ragulator complex protein LAMTOR4 - Bos taurus (Bovine) - LAMTOR4 gene As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). Taurus_UMD|evm.model.AC_000182.1.654 Q08BN9 NXPE3_DANRE 38.604 0.863063 0.980565 nxpe3 - NXPE family member 3 precursor - Danio rerio (Zebrafish) - nxpe3 gene Taurus_UMD|evm.model.AC_000182.1.655 Q9UKJ1 PILRA_HUMAN 49.091 0.683007 1.0099 PILRA - Paired immunoglobulin-like type 2 receptor alpha precursor - Homo sapiens (Human) - PILRA gene Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. Taurus_UMD|evm.model.AC_000182.1.656 Q2HJB0 MBLC1_BOVIN 99.620 0.992424 1.0038 MBLAC1 - Metallo-beta-lactamase domain-containing protein 1 - Bos taurus (Bovine) - MBLAC1 gene Taurus_UMD|evm.model.AC_000182.1.657 Q3SWX1 CNPY4_BOVIN 100.000 0.991667 1.00418 CNPY4 - Protein canopy homolog 4 precursor - Bos taurus (Bovine) - CNPY4 gene Plays a role in the regulation of the cell surface expression of TLR4. Taurus_UMD|evm.model.AC_000182.1.658 Q63801 TAF6_RAT 97.489 0.995582 1.00147 Taf6 - Transcription initiation factor TFIID subunit 6 - Rattus norvegicus (Rat) - Taf6 gene TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (By similarity). Taurus_UMD|evm.model.AC_000182.1.659 Q29RY8 AP4M1_BOVIN 100.000 0.995585 1.00221 AP4M1 - AP-4 complex subunit mu-1 - Bos taurus (Bovine) - AP4M1 gene Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal. Taurus_UMD|evm.model.AC_000182.1.660 Q3ZBH9 MCM7_BOVIN 100.000 0.997222 1.00139 MCM7 - DNA replication licensing factor MCM7 - Bos taurus (Bovine) - MCM7 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. Taurus_UMD|evm.model.AC_000182.1.661 A6QQ21 CSN6_BOVIN 99.691 0.993846 1.00309 COPS6 - COP9 signalosome complex subunit 6 - Bos taurus (Bovine) - COPS6 gene Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Has some glucocorticoid receptor-responsive activity (By similarity). Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets, including SFN (By similarity). Taurus_UMD|evm.model.AC_000182.1.662 P17036 ZNF3_HUMAN 90.604 0.995536 1.00448 ZNF3 - Zinc finger protein 3 - Homo sapiens (Human) - ZNF3 gene Involved in cell differentiation and/or proliferation. Taurus_UMD|evm.model.AC_000182.1.663 A2T7L7 ZSC21_PONPY 84.110 0.991525 0.997886 ZSCAN21 - Zinc finger and SCAN domain-containing protein 21 - Pongo pygmaeus (Bornean orangutan) - ZSCAN21 gene Strong transcriptional activator (By similarity). Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (By similarity). Taurus_UMD|evm.model.AC_000182.1.664 Q5R670 ZKSC1_PONAB 91.652 0.996454 1.00178 ZKSCAN1 - Zinc finger protein with KRAB and SCAN domains 1 - Pongo abelii (Sumatran orangutan) - ZKSCAN1 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.665 Q3ZCH5 ZA2G_BOVIN 100.000 0.993333 1.00334 AZGP1 - Zinc-alpha-2-glycoprotein precursor - Bos taurus (Bovine) - AZGP1 gene Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. Taurus_UMD|evm.model.AC_000182.1.666 A3KN25 CXG3_BOVIN 100.000 0.992754 1.00364 GJC3 - Gap junction gamma-3 protein - Bos taurus (Bovine) - GJC3 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Taurus_UMD|evm.model.AC_000182.1.667 Q9C037 TRIM4_HUMAN 68.371 0.976109 0.586 TRIM4 - E3 ubiquitin-protein ligase TRIM4 - Homo sapiens (Human) - TRIM4 gene E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction. Taurus_UMD|evm.model.AC_000182.1.668 P79102 CP3AS_BOVIN 99.748 0.994975 0.78501 CYP3A28 - Cytochrome P450 3A28 - Bos taurus (Bovine) - CYP3A28 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Taurus_UMD|evm.model.AC_000182.1.669 P79102 CP3AS_BOVIN 100.000 0.246575 0.575937 CYP3A28 - Cytochrome P450 3A28 - Bos taurus (Bovine) - CYP3A28 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Taurus_UMD|evm.model.AC_000182.1.670 Q29496 CP3AO_SHEEP 91.849 0.996032 1.00199 CYP3A24 - Cytochrome P450 3A24 - Ovis aries (Sheep) - CYP3A24 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Taurus_UMD|evm.model.AC_000182.1.671 Q29496 CP3AO_SHEEP 92.843 0.996032 1.00199 CYP3A24 - Cytochrome P450 3A24 - Ovis aries (Sheep) - CYP3A24 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Taurus_UMD|evm.model.AC_000182.1.672 Q29496 CP3AO_SHEEP 85.686 0.995585 0.900596 CYP3A24 - Cytochrome P450 3A24 - Ovis aries (Sheep) - CYP3A24 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Taurus_UMD|evm.model.AC_000182.1.673 Q6NSZ9 ZSC25_HUMAN 83.794 0.952548 1.04596 ZSCAN25 - Zinc finger and SCAN domain-containing protein 25 - Homo sapiens (Human) - ZSCAN25 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.674 P0DP42 T225B_HUMAN 73.303 0.969163 1.02715 TMEM225B - Transmembrane protein 225B - Homo sapiens (Human) - TMEM225B gene Taurus_UMD|evm.model.AC_000182.1.676 Q15937 ZNF79_HUMAN 61.024 0.744118 0.682731 ZNF79 - Zinc finger protein 79 - Homo sapiens (Human) - ZNF79 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.677 Q8N720 ZN655_HUMAN 86.667 0.0715447 1.25255 ZNF655 - Zinc finger protein 655 - Homo sapiens (Human) - ZNF655 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.678 Q8TCP9 F200A_HUMAN 87.847 0.996534 1.00698 FAM200A - Protein FAM200A - Homo sapiens (Human) - FAM200A gene Taurus_UMD|evm.model.AC_000182.1.679 Q5FWF6 ZN789_HUMAN 70.118 0.961451 1.03765 ZNF789 - Zinc finger protein 789 - Homo sapiens (Human) - ZNF789 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.680 A2T7D2 ZKSC5_PANTR 85.697 0.997599 0.992849 ZKSCAN5 - Zinc finger protein with KRAB and SCAN domains 5 - Pan troglodytes (Chimpanzee) - ZKSCAN5 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.681 Q53GI3 ZN394_HUMAN 71.296 0.33437 1.14617 ZNF394 - Zinc finger protein 394 - Homo sapiens (Human) - ZNF394 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.682 Q28851 ATPK_BOVIN 100.000 0.977528 1.01136 ATP5MF - ATP synthase subunit f, mitochondrial - Bos taurus (Bovine) - ATP5MF gene Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Taurus_UMD|evm.model.AC_000182.1.683 O95639 CPSF4_HUMAN 99.257 0.992593 1.00372 CPSF4 - Cleavage and polyadenylation specificity factor subunit 4 - Homo sapiens (Human) - CPSF4 gene Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). Taurus_UMD|evm.model.AC_000182.1.684 O75127 PTCD1_HUMAN 77.589 0.923684 1.08571 PTCD1 - Pentatricopeptide repeat-containing protein 1, mitochondrial - Homo sapiens (Human) - PTCD1 gene Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs. Taurus_UMD|evm.model.AC_000182.1.685 O70454 BUD31_RAT 100.000 0.986207 1.00694 Bud31 - Protein BUD31 homolog - Rattus norvegicus (Rat) - Bud31 gene Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. Taurus_UMD|evm.model.AC_000182.1.686 Q13442 HAP28_HUMAN 98.901 0.989071 1.01105 PDAP1 - 28 kDa heat- and acid-stable phosphoprotein - Homo sapiens (Human) - PDAP1 gene Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. Taurus_UMD|evm.model.AC_000182.1.687 Q58CQ2 ARC1B_BOVIN 100.000 0.994638 1.00269 ARPC1B - Actin-related protein 2/3 complex subunit 1B - Bos taurus (Bovine) - ARPC1B gene Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Taurus_UMD|evm.model.AC_000182.1.688 Q1JP79 ARC1A_BOVIN 100.000 0.994609 1.0027 ARPC1A - Actin-related protein 2/3 complex subunit 1A - Bos taurus (Bovine) - ARPC1A gene Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). Taurus_UMD|evm.model.AC_000182.1.689 F1PT61 MYH16_CANLF 56.907 0.765547 0.72487 MYH16 - Myosin-16 - Canis lupus familiaris (Dog) - MYH16 gene May play a role in masticatory muscles contraction. Taurus_UMD|evm.model.AC_000182.1.690 C1JZ66 IMA8_BOVIN 100.000 0.968401 1.03065 KPNA7 - Importin subunit alpha-8 - Bos taurus (Bovine) - KPNA7 gene Functions in nuclear protein import. Taurus_UMD|evm.model.AC_000182.1.691 Q9CUN6 SMUF1_MOUSE 97.948 0.997268 1.00137 Smurf1 - E3 ubiquitin-protein ligase SMURF1 - Mus musculus (Mouse) - Smurf1 gene E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway (By similarity). Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway (By similarity). Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA (By similarity). Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (By similarity). Taurus_UMD|evm.model.AC_000182.1.692 Q9Y4A5 TRRAP_HUMAN 97.860 0.999481 0.997668 TRRAP - Transformation/transcription domain-associated protein - Homo sapiens (Human) - TRRAP gene Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). Taurus_UMD|evm.model.AC_000182.1.694 Q8N3G9 TM130_HUMAN 86.667 0.995413 1.0023 TMEM130 - Transmembrane protein 130 precursor - Homo sapiens (Human) - TMEM130 gene Golgi apparatus, integral component of plasma membrane Taurus_UMD|evm.model.AC_000182.1.696 P47972 NPTX2_HUMAN 96.135 0.956019 1.00232 NPTX2 - Neuronal pentraxin-2 precursor - Homo sapiens (Human) - NPTX2 gene Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000182.1.697 Q9UHR4 BI2L1_HUMAN 76.908 0.995943 0.964775 BAIAP2L1 - Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 - Homo sapiens (Human) - BAIAP2L1 gene May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Taurus_UMD|evm.model.AC_000182.1.698 Q32L83 BRI3_BOVIN 100.000 0.112245 5.53226 BRI3 - Brain protein I3 - Bos taurus (Bovine) - BRI3 gene Participates in tumor necrosis factor-alpha (TNF)-induced cell death. May be a target of Wnt/beta-catenin signaling in the liver. Taurus_UMD|evm.model.AC_000182.1.699 Q7Z6L1 TCPR1_HUMAN 83.846 0.875211 0.509013 TECPR1 - Tectonin beta-propeller repeat-containing protein 1 - Homo sapiens (Human) - TECPR1 gene Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. Taurus_UMD|evm.model.AC_000182.1.700 Q7RTS1 BHA15_HUMAN 79.058 0.989362 0.994709 BHLHA15 - Class A basic helix-loop-helix protein 15 - Homo sapiens (Human) - BHLHA15 gene Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity). Taurus_UMD|evm.model.AC_000182.1.702 Q8IWU2 LMTK2_HUMAN 75.703 0.986631 0.995343 LMTK2 - Serine/threonine-protein kinase LMTK2 - Homo sapiens (Human) - LMTK2 gene Phosphorylates PPP1C, phosphorylase b and CFTR. Taurus_UMD|evm.model.AC_000182.1.703 O35508 ONCO_CAVPO 95.699 0.884615 0.954128 OCM - Oncomodulin - Cavia porcellus (Guinea pig) - OCM gene Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions (By similarity). Taurus_UMD|evm.model.AC_000182.1.704 Q0VD30 CCZ1_BOVIN 100.000 0.995842 1.00208 CCZ1 - Vacuolar fusion protein CCZ1 homolog - Bos taurus (Bovine) - CCZ1 gene Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Taurus_UMD|evm.model.AC_000182.1.705 Q1JPG1 RS10B_BOVIN 95.982 0.997706 1.0381 RSPH10B - Radial spoke head 10 homolog B - Bos taurus (Bovine) - RSPH10B gene Taurus_UMD|evm.model.AC_000182.1.706 O95744 PM2P2_HUMAN 82.486 0.187432 3.10774 PMS2P2 - Putative postmeiotic segregation increased 2-like protein 2 - Homo sapiens (Human) - PMS2P2 gene mismatch repair complex, MutLalpha complex, ATPase activity, mismatch repair, somatic hypermutation of immunoglobulin genes Taurus_UMD|evm.model.AC_000182.1.707 Q0II26 AIMP2_BOVIN 100.000 0.993769 1.00313 AIMP2 - Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 - Bos taurus (Bovine) - AIMP2 gene Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. Taurus_UMD|evm.model.AC_000182.1.708 Q9BQI3 E2AK1_HUMAN 81.270 0.993681 1.00476 EIF2AK1 - Eukaryotic translation initiation factor 2-alpha kinase 1 - Homo sapiens (Human) - EIF2AK1 gene Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:32132706, PubMed:32132707). Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:32132706, PubMed:32132707). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (By similarity). This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (By similarity). Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (By similarity). In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (By similarity). It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes (By similarity). May also regulate endoplasmic reticulum (ER) stress during acute heme-deficient conditions (By similarity). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (PubMed:32132706, PubMed:32132707). Taurus_UMD|evm.model.AC_000182.1.710 E1B9W9 UBP42_BOVIN 100.000 0.997738 0.994749 USP42 - Ubiquitin carboxyl-terminal hydrolase 42 - Bos taurus (Bovine) - USP42 gene Deubiquitinating enzyme which may play an important role during spermatogenesis. Taurus_UMD|evm.model.AC_000182.1.711 P97696 CYH3_RAT 89.873 0.964912 0.9975 Cyth3 - Cytohesin-3 - Rattus norvegicus (Rat) - Cyth3 gene Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity). Taurus_UMD|evm.model.AC_000182.1.712 Q6RUV5 RAC1_RAT 100.000 0.90404 1.03125 Rac1 - Ras-related C3 botulinum toxin substrate 1 precursor - Rattus norvegicus (Rat) - Rac1 gene Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles (PubMed:16040606, PubMed:16549782). Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (By similarity). In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (PubMed:16040606). In glioma cells, promotes cell migration and invasion (PubMed:20696765). In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning (PubMed:19029984). Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). In neurons, is involved in dendritic spine formation and synaptic plasticity (PubMed:25498153). In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX (PubMed:12695502). In synapses, may mediate the regulation of F-actin cluster formation performed by SHANK3 (PubMed:24089484). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (PubMed:25284783). Taurus_UMD|evm.model.AC_000182.1.713 Q8NCG7 DGLB_HUMAN 83.185 0.997015 0.997024 DAGLB - Diacylglycerol lipase-beta - Homo sapiens (Human) - DAGLB gene Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity). Taurus_UMD|evm.model.AC_000182.1.714 Q5U305 ERD22_RAT 100.000 0.986755 0.712264 Kdelr2 - ER lumen protein-retaining receptor 2 - Rattus norvegicus (Rat) - Kdelr2 gene Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity). Taurus_UMD|evm.model.AC_000182.1.715 A4D2P6 GRD2I_HUMAN 87.570 0.980253 1.04542 GRID2IP - Delphilin - Homo sapiens (Human) - GRID2IP gene Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules. Taurus_UMD|evm.model.AC_000182.1.716 Q58DT3 ZDHC4_BOVIN 99.708 0.934426 1.06706 ZDHHC4 - Palmitoyltransferase ZDHHC4 - Bos taurus (Bovine) - ZDHHC4 gene Palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates including the D(2) dopamine receptor DRD2. Taurus_UMD|evm.model.AC_000182.1.717 Q96N11 CG026_HUMAN 93.304 0.993318 1 C7orf26 - Uncharacterized protein C7orf26 - Homo sapiens (Human) - C7orf26 gene Taurus_UMD|evm.model.AC_000182.1.718 P0CG23 ZN853_HUMAN 81.749 0.414356 0.930197 ZNF853 - Zinc finger protein 853 - Homo sapiens (Human) - ZNF853 gene DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000182.1.719 A6NFI3 ZN316_HUMAN 82.428 0.99798 0.986056 ZNF316 - Zinc finger protein 316 - Homo sapiens (Human) - ZNF316 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.721 P17014 ZNF12_HUMAN 89.270 0.712821 1.39885 ZNF12 - Zinc finger protein 12 - Homo sapiens (Human) - ZNF12 gene Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity. Taurus_UMD|evm.model.AC_000182.1.722 A6NJR5 SPDL3_HUMAN 59.603 0.615063 0.824138 Putative speedy protein-like protein 3 - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000182.1.724 Q9NYW8 RBAK_HUMAN 86.453 0.995798 1 RBAK - RB-associated KRAB zinc finger protein - Homo sapiens (Human) - RBAK gene May repress E2F-dependent transcription. May promote AR-dependent transcription. Taurus_UMD|evm.model.AC_000182.1.725 Q96KK4 O10C1_HUMAN 45.981 0.95092 1.04487 OR10C1 - Olfactory receptor 10C1 - Homo sapiens (Human) - OR10C1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000182.1.726 Q4R6J4 ZN684_MACFA 44.444 0.221445 1.13492 ZNF684 - Zinc finger protein 684 - Macaca fascicularis (Crab-eating macaque) - ZNF684 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000182.1.728 Q9NWF9 RN216_HUMAN 82.632 0.997843 1.07044 RNF216 - E3 ubiquitin-protein ligase RNF216 - Homo sapiens (Human) - RNF216 gene Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. Taurus_UMD|evm.model.AC_000182.1.729 Q16658 FSCN1_HUMAN 93.103 0.995951 1.00203 FSCN1 - Fascin - Homo sapiens (Human) - FSCN1 gene Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). Taurus_UMD|evm.model.AC_000182.1.731 P60710 ACTB_MOUSE 96.615 0.994805 1.02667 Actb - Actin, cytoplasmic 1 - Mus musculus (Mouse) - Actb gene Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:23558171, PubMed:25759381). Taurus_UMD|evm.model.AC_000182.1.732 Q96ME1 FXL18_HUMAN 85.103 0.936798 0.884472 FBXL18 - F-box/LRR-repeat protein 18 - Homo sapiens (Human) - FBXL18 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Taurus_UMD|evm.model.AC_000182.1.734 O15417 TNC18_HUMAN 84.962 0.866599 0.997642 TNRC18 - Trinucleotide repeat-containing gene 18 protein - Homo sapiens (Human) - TNRC18 gene cytosol, mitochondrion, nuclear membrane, nucleoplasm Taurus_UMD|evm.model.AC_000182.1.735 Q7RTT9 S29A4_HUMAN 86.629 0.996183 0.988679 SLC29A4 - Equilibrative nucleoside transporter 4 - Homo sapiens (Human) - SLC29A4 gene Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia. Taurus_UMD|evm.model.AC_000182.1.736 Q5ZHN3 WIPI2_CHICK 92.202 0.995423 1.00229 WIPI2 - WD repeat domain phosphoinositide-interacting protein 2 - Gallus gallus (Chicken) - WIPI2 gene Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Taurus_UMD|evm.model.AC_000182.1.737 Q8R189 PAQRA_MOUSE 93.388 0.975709 1 Mmd2 - Monocyte to macrophage differentiation factor 2 - Mus musculus (Mouse) - Mmd2 gene perinuclear region of cytoplasm, protein kinase activity, positive regulation of neuron differentiation, positive regulation of protein kinase activity, positive regulation of Ras protein signal transduction, regulation of protein localization Taurus_UMD|evm.model.AC_000182.1.738 Q96JH8 RADIL_HUMAN 86.034 0.936842 0.176744 RADIL - Ras-associating and dilute domain-containing protein - Homo sapiens (Human) - RADIL gene Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. Taurus_UMD|evm.model.AC_000182.1.739 P51006 PAPO3_XENLA 87.936 0.578538 1.6075 Poly(A) polymerase type 3 - Xenopus laevis (African clawed frog) Taurus_UMD|evm.model.AC_000182.1.740 Q96JH8 RADIL_HUMAN 78.282 0.996399 0.774884 RADIL - Ras-associating and dilute domain-containing protein - Homo sapiens (Human) - RADIL gene Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. Taurus_UMD|evm.model.AC_000182.1.741 O43299 AP5Z1_HUMAN 74.629 0.954976 1.04585 AP5Z1 - AP-5 complex subunit zeta-1 - Homo sapiens (Human) - AP5Z1 gene As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. Taurus_UMD|evm.model.AC_000182.1.742 P42128 FOXK1_MOUSE 90.747 0.996716 0.84701 Foxk1 - Forkhead box protein K1 - Mus musculus (Mouse) - Foxk1 gene Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (PubMed:25402684, PubMed:29861159, PubMed:30700909). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:25402684, PubMed:29861159, PubMed:30700909). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (PubMed:30700909). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (PubMed:30700909). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (PubMed:30700909). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (PubMed:29861159). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (PubMed:25402684). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (PubMed:8007964, PubMed:9271401, PubMed:12446708, PubMed:22956541). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (PubMed:8007964, PubMed:9271401). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (PubMed:12446708, PubMed:22956541). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (PubMed:9271401, PubMed:22956541). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (PubMed:10792059). Represses myogenic differentiation by inhibiting MEFC activity (PubMed:22956541). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (By similarity). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (By similarity). Taurus_UMD|evm.model.AC_000182.1.743 Q7Z5N4 SDK1_HUMAN 84.517 0.949177 0.933574 SDK1 - Protein sidekick-1 precursor - Homo sapiens (Human) - SDK1 gene Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. Taurus_UMD|evm.model.AC_000182.1.747 Q9BXL7 CAR11_HUMAN 93.501 0.998268 1.00087 CARD11 - Caspase recruitment domain-containing protein 11 - Homo sapiens (Human) - CARD11 gene Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). Taurus_UMD|evm.model.AC_000182.1.748 Q03113 GNA12_HUMAN 93.194 0.994536 0.96063 GNA12 - Guanine nucleotide-binding protein subunit alpha-12 - Homo sapiens (Human) - GNA12 gene Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986). Taurus_UMD|evm.model.AC_000182.1.750 Q400G9 AMZ1_HUMAN 75.794 0.801613 1.24498 AMZ1 - Archaemetzincin-1 - Homo sapiens (Human) - AMZ1 gene Probable zinc metalloprotease. Taurus_UMD|evm.model.AC_000182.1.751 D2I4M3 BRAT1_AILME 76.914 0.969011 1.01944 BRAT1 - BRCA1-associated ATM activator 1 - Ailuropoda melanoleuca (Giant panda) - BRAT1 gene Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors. Taurus_UMD|evm.model.AC_000182.1.752 Q6IPM2 IQCE_HUMAN 64.910 0.988904 1.03741 IQCE - IQ domain-containing protein E - Homo sapiens (Human) - IQCE gene Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis (PubMed:28488682). Taurus_UMD|evm.model.AC_000182.1.753 Q9C0H2 TTYH3_HUMAN 95.211 0.992381 1.00382 TTYH3 - Protein tweety homolog 3 - Homo sapiens (Human) - TTYH3 gene Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. Taurus_UMD|evm.model.AC_000182.1.754 Q2KJ92 LFNG_BOVIN 100.000 0.994751 1.00263 LFNG - Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe - Bos taurus (Bovine) - LFNG gene Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning. Taurus_UMD|evm.model.AC_000182.1.756 Q9D1U0 GRIFN_MOUSE 80.357 0.552239 1.39583 Grifin - Grifin - Mus musculus (Mouse) - Grifin gene cytoplasm Taurus_UMD|evm.model.AC_000182.1.757 Q99LL3 CHSTC_MOUSE 80.430 0.988095 1.00239 Chst12 - Carbohydrate sulfotransferase 12 - Mus musculus (Mouse) - Chst12 gene Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor (By similarity). Taurus_UMD|evm.model.AC_000182.1.759 Q2TAC6 KIF19_HUMAN 53.406 0.804805 1.001 KIF19 - Kinesin-like protein KIF19 - Homo sapiens (Human) - KIF19 gene Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips. Taurus_UMD|evm.model.AC_000182.1.760 A7MB16 EIF3B_BOVIN 95.674 0.997361 0.964377 EIF3B - Eukaryotic translation initiation factor 3 subunit B - Bos taurus (Bovine) - EIF3B gene RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Taurus_UMD|evm.model.AC_000182.1.761 Q2KHV6 SNX8_BOVIN 100.000 0.995652 1.00218 SNX8 - Sorting nexin-8 - Bos taurus (Bovine) - SNX8 gene May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (By similarity). Taurus_UMD|evm.model.AC_000182.1.762 P36639 8ODP_HUMAN 90.385 0.987261 0.796954 NUDT1 - 7,8-dihydro-8-oxoguanine triphosphatase precursor - Homo sapiens (Human) - NUDT1 gene Antimutagenic (PubMed:8226881, PubMed:7713500, PubMed:10608900). Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools (PubMed:28679043). Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress (PubMed:12857738, PubMed:24695224, PubMed:24695225). Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004). Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP (PubMed:10373420, PubMed:11139615). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). Taurus_UMD|evm.model.AC_000182.1.763 Q9UI43 MRM2_HUMAN 84.711 0.225234 4.34959 MRM2 - rRNA methyltransferase 2, mitochondrial precursor - Homo sapiens (Human) - MRM2 gene S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Taurus_UMD|evm.model.AC_000182.1.765 P0C7U0 ELFN1_HUMAN 81.731 0.997506 0.968599 ELFN1 - Protein ELFN1 precursor - Homo sapiens (Human) - ELFN1 gene Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. Taurus_UMD|evm.model.AC_000182.1.770 Q2NKS3 PSMG3_BOVIN 100.000 0.98374 1.0082 PSMG3 - Proteasome assembly chaperone 3 - Bos taurus (Bovine) - PSMG3 gene Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes. Taurus_UMD|evm.model.AC_000182.1.771 Q1RMW2 T184A_BOVIN 100.000 0.995181 1.00242 TMEM184A - Transmembrane protein 184A - Bos taurus (Bovine) - TMEM184A gene Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity). Taurus_UMD|evm.model.AC_000182.1.772 Q61827 MAFK_MOUSE 94.268 0.987342 1.01282 Mafk - Transcription factor MafK - Mus musculus (Mouse) - Mafk gene Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (By similarity). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9240432). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (By similarity). Taurus_UMD|evm.model.AC_000182.1.773 Q8N201 INT1_HUMAN 88.828 0.999087 1 INTS1 - Integrator complex subunit 1 - Homo sapiens (Human) - INTS1 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). Taurus_UMD|evm.model.AC_000182.1.774 Q8IY33 MILK2_HUMAN 60.309 0.986425 0.977876 MICALL2 - MICAL-like protein 2 - Homo sapiens (Human) - MICALL2 gene Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Taurus_UMD|evm.model.AC_000182.1.778 Q50D79 UNC4_DANRE 80.769 0.116667 1.40426 uncx - Homeobox protein unc-4 homolog - Danio rerio (Zebrafish) - uncx gene Transcription factor involved in somitogenesis and neurogenesis. Taurus_UMD|evm.model.AC_000182.1.780 Q5U2P3 ZFN2A_RAT 73.881 0.311475 2.49708 Zfand2a - AN1-type zinc finger protein 2A - Rattus norvegicus (Rat) - Zfand2a gene proteasome complex, cellular response to arsenic-containing substance, positive regulation of proteasomal ubiquitin-dependent protein catabolic process Taurus_UMD|evm.model.AC_000182.1.781 Q8TAV3 CP2W1_HUMAN 80.892 0.951417 1.00816 CYP2W1 - Cytochrome P450 2W1 precursor - Homo sapiens (Human) - CYP2W1 gene A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism (PubMed:22591743, PubMed:26936974). Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retinal are potential endogenous substrates (PubMed:26936974). Catalyzes both epoxidation of double bonds and hydroxylation of carbon hydrogen bonds of the fatty acyl chain of 1-acylphospholipids/2-lysophospholipids. Can metabolize various lysophospholipids classes including lysophosphatidylcholines (LPCs), lysophosphatidylinositols (LPIs), lysophosphatidylserines (LPSs), lysophosphatidylglycerols (LPGs), lysophosphatidylethanolamines (LPEs) and lysophosphatidic acids (LPAs) (PubMed:22591743). Has low or no activity toward 2-acylphospholipids/1-lysophospholipids, diacylphospholipids and free fatty acids (PubMed:26936974, PubMed:22591743). May play a role in tumorigenesis by activating procarcinogens such as aflatoxin B1, polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:20805301, PubMed:16551781, PubMed:24278521). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:22591743, PubMed:26936974). Taurus_UMD|evm.model.AC_000182.1.783 A8E4L1 COX19_BOVIN 100.000 0.977778 1.01124 COX19 - Cytochrome c oxidase assembly protein COX19 - Bos taurus (Bovine) - COX19 gene Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity). Taurus_UMD|evm.model.AC_000182.1.784 O75689 ADAP1_HUMAN 90.642 0.994667 1.00267 ADAP1 - Arf-GAP with dual PH domain-containing protein 1 - Homo sapiens (Human) - ADAP1 gene GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Taurus_UMD|evm.model.AC_000182.1.785 O94901 SUN1_HUMAN 82.129 0.839228 0.383005 SUN1 - SUN domain-containing protein 1 - Homo sapiens (Human) - SUN1 gene As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenenis (By similarity). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709). Taurus_UMD|evm.model.AC_000182.1.786 Q0P5I8 GET4_BOVIN 100.000 0.816817 1.02462 GET4 - Golgi to ER traffic protein 4 homolog - Bos taurus (Bovine) - GET4 gene As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. Taurus_UMD|evm.model.AC_000182.1.787 O94901 SUN1_HUMAN 72.146 0.345763 0.726601 SUN1 - SUN domain-containing protein 1 - Homo sapiens (Human) - SUN1 gene As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenenis (By similarity). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709). Taurus_UMD|evm.model.AC_000182.1.789 Q86Y56 DAAF5_HUMAN 71.379 0.997622 0.983626 DNAAF5 - Dynein axonemal assembly factor 5 - Homo sapiens (Human) - DNAAF5 gene Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. Taurus_UMD|evm.model.AC_000182.1.790 Q5ZM91 KAP0_CHICK 76.190 0.405941 0.264398 PRKAR1A - cAMP-dependent protein kinase type I-alpha regulatory subunit - Gallus gallus (Chicken) - PRKAR1A gene cAMP-dependent protein kinase complex, cAMP-dependent protein kinase regulator activity, regulation of cAMP-mediated signaling, regulation of protein kinase A signaling Taurus_UMD|evm.model.AC_000182.1.792 P31321 KAP1_HUMAN 96.943 0.991304 0.603675 PRKAR1B - cAMP-dependent protein kinase type I-beta regulatory subunit - Homo sapiens (Human) - PRKAR1B gene Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Taurus_UMD|evm.model.AC_000182.1.793 Q2KJ15 PDGFA_BOVIN 99.052 0.990566 1.00474 PDGFA - Platelet-derived growth factor subunit A precursor - Bos taurus (Bovine) - PDGFA gene Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity). Taurus_UMD|evm.model.AC_000182.1.795 A0A1W2PRP0 FOXL3_HUMAN 72.152 0.990868 0.939914 FOXL3 - Forkhead box protein L3 - Homo sapiens (Human) - FOXL3 gene Probable transcriptional regulator. Taurus_UMD|evm.model.AC_000182.1.797 Q8IXL6 FA20C_HUMAN 86.803 0.87725 1.04623 FAM20C - Extracellular serine/threonine protein kinase FAM20C precursor - Homo sapiens (Human) - FAM20C gene Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039). Taurus_UMD|evm.model.AC_000182.1.798 Q0EEE2 PTHD3_MOUSE 69.073 0.992505 1.03091 Ptchd3 - Patched domain-containing protein 3 - Mus musculus (Mouse) - Ptchd3 gene May play a role in sperm development or sperm function. Taurus_UMD|evm.model.AC_000183.1.1 Q9UPS8 ANR26_HUMAN 63.492 0.102796 0.711111 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000183.1.2 Q9UPS8 ANR26_HUMAN 56.173 0.756757 0.0865497 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000183.1.3 Q9BQI4 CCDC3_HUMAN 62.434 0.935135 0.685185 CCDC3 - Coiled-coil domain-containing protein 3 precursor - Homo sapiens (Human) - CCDC3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (PubMed:25193116). Positively regulates lipid accumulation in adipose cells (By similarity). Taurus_UMD|evm.model.AC_000183.1.4 P97516 TEF_PHOSU 66.667 0.44186 0.38914 TEF - Thyrotroph embryonic factor - Phodopus sungorus (Striped hairy-footed hamster) - TEF gene Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3' (By similarity). Taurus_UMD|evm.model.AC_000183.1.5 Q8NI29 FBX27_HUMAN 42.353 0.929104 0.946996 FBXO27 - F-box only protein 27 - Homo sapiens (Human) - FBXO27 gene Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Taurus_UMD|evm.model.AC_000183.1.6 Q03274 PO22_POPJA 28.824 0.470588 0.50211 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 - Popillia japonica (Japanese beetle) Taurus_UMD|evm.model.AC_000183.1.7 D3ZDK2 UB2D1_RAT 100.000 0.986486 1.0068 Ube2d1 - Ubiquitin-conjugating enzyme E2 D1 - Rattus norvegicus (Rat) - Ube2d1 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4 (By similarity). Mediates ubiquitination of PEX5. Taurus_UMD|evm.model.AC_000183.1.8 P16116 ALDR_BOVIN 94.286 0.990196 0.971429 AKR1B1 - Aldo-keto reductase family 1 member B1 - Bos taurus (Bovine) - AKR1B1 gene Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Taurus_UMD|evm.model.AC_000183.1.9 Q3ZBU2 CISD1_BOVIN 100.000 0.866071 1.0566 CISD1 - CDGSH iron-sulfur domain-containing protein 1 - Bos taurus (Bovine) - CISD1 gene Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation. May be involved in Fe-S cluster shuttling and/or in redox reactions (By similarity). Taurus_UMD|evm.model.AC_000183.1.10 Q8NFU5 IPMK_HUMAN 84.615 0.994832 0.930288 IPMK - Inositol polyphosphate multikinase - Homo sapiens (Human) - IPMK gene Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:30420721, PubMed:28882892). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity). Taurus_UMD|evm.model.AC_000183.1.13 Q93008 USP9X_HUMAN 98.361 0.937984 0.050509 USP9X - Probable ubiquitin carboxyl-terminal hydrolase FAF-X - Homo sapiens (Human) - USP9X gene Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration (PubMed:16322459, PubMed:18254724, PubMed:19135894, PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity (PubMed:29626158). Taurus_UMD|evm.model.AC_000183.1.15 Q8WW12 PCNP_HUMAN 59.322 0.965517 0.325843 PCNP - PEST proteolytic signal-containing nuclear protein - Homo sapiens (Human) - PCNP gene May be involved in cell cycle regulation. Taurus_UMD|evm.model.AC_000183.1.16 P31625 PRO_JSRV 68.000 0.742424 0.0762125 pro - Gag-Pro polyprotein - Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) - pro gene Matrix protein. Taurus_UMD|evm.model.AC_000183.1.19 Q2TBH8 ZWINT_BOVIN 99.650 0.993031 1.0035 ZWINT - ZW10 interactor - Bos taurus (Bovine) - ZWINT gene Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity). Taurus_UMD|evm.model.AC_000183.1.20 Q13309 SKP2_HUMAN 87.843 0.992188 0.603774 SKP2 - S-phase kinase-associated protein 2 - Homo sapiens (Human) - SKP2 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:17962192, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Taurus_UMD|evm.model.AC_000183.1.21 Q7Z434 MAVS_HUMAN 46.789 0.923077 0.192593 MAVS - Mitochondrial antiviral-signaling protein - Homo sapiens (Human) - MAVS gene Required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:20127681, PubMed:21170385). Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20451243, PubMed:23087404, PubMed:25636800, PubMed:20127681, PubMed:21170385, PubMed:20628368). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Taurus_UMD|evm.model.AC_000183.1.22 Q5RBN9 TAD2B_PONAB 59.322 0.456693 0.302381 TADA2B - Transcriptional adapter 2-beta - Pongo abelii (Sumatran orangutan) - TADA2B gene Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. Taurus_UMD|evm.model.AC_000183.1.23 Q96QU1 PCD15_HUMAN 97.130 0.997314 0.571355 PCDH15 - Protocadherin-15 precursor - Homo sapiens (Human) - PCDH15 gene Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function. Taurus_UMD|evm.model.AC_000183.1.26 P00348 HCDH_PIG 89.809 0.993631 1 HADH - Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor - Sus scrofa (Pig) - HADH gene Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:9593854, PubMed:2817332). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Taurus_UMD|evm.model.AC_000183.1.27 O02659 MBL2_BOVIN 100.000 0.992 1.00402 MBL - Mannose-binding protein C precursor - Bos taurus (Bovine) - MBL gene Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). Taurus_UMD|evm.model.AC_000183.1.28 Q0VC16 TGO1_BOVIN 35.165 0.166052 0.284514 MIA3 - Transport and Golgi organization protein 1 homolog precursor - Bos taurus (Bovine) - MIA3 gene Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum. Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES. Taurus_UMD|evm.model.AC_000183.1.29 O94907 DKK1_HUMAN 83.951 0.258065 1.16541 DKK1 - Dickkopf-related protein 1 precursor - Homo sapiens (Human) - DKK1 gene Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity). Taurus_UMD|evm.model.AC_000183.1.30 Q13976 KGP1_HUMAN 99.469 0.930693 0.602086 PRKG1 - cGMP-dependent protein kinase 1 - Homo sapiens (Human) - PRKG1 gene Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. Taurus_UMD|evm.model.AC_000183.1.32 P00516 KGP1_BOVIN 100.000 0.74026 0.114754 PRKG1 - cGMP-dependent protein kinase 1 - Bos taurus (Bovine) - PRKG1 gene Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle (By similarity). Taurus_UMD|evm.model.AC_000183.1.33 Q9H0L4 CSTFT_HUMAN 89.857 0.99679 1.01136 CSTF2T - Cleavage stimulation factor subunit 2 tau variant - Homo sapiens (Human) - CSTF2T gene May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity). Taurus_UMD|evm.model.AC_000183.1.35 Q13976 KGP1_HUMAN 100.000 0.617978 0.132638 PRKG1 - cGMP-dependent protein kinase 1 - Homo sapiens (Human) - PRKG1 gene Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. Taurus_UMD|evm.model.AC_000183.1.37 P00516 KGP1_BOVIN 93.814 0.950495 0.150522 PRKG1 - cGMP-dependent protein kinase 1 - Bos taurus (Bovine) - PRKG1 gene Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling alters also gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle (By similarity). Taurus_UMD|evm.model.AC_000183.1.38 Q9NQ94 A1CF_HUMAN 95.966 0.996644 1.00337 A1CF - APOBEC1 complementation factor - Homo sapiens (Human) - A1CF gene Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. Taurus_UMD|evm.model.AC_000183.1.39 Q9NR71 ASAH2_HUMAN 82.730 0.852205 1.07564 ASAH2 - Neutral ceramidase - Homo sapiens (Human) - ASAH2 gene Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:10781606, PubMed:16229686, PubMed:26190575). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:15946935, PubMed:19345744, PubMed:24798654). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:11278489, PubMed:17475390). Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (PubMed:16061940). Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (By similarity). This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract (By similarity). Taurus_UMD|evm.model.AC_000183.1.40 A0AAS4 SMS1_PIG 96.852 0.995169 0.990431 SGMS1 - Phosphatidylcholine:ceramide cholinephosphotransferase 1 - Sus scrofa (Pig) - SGMS1 gene Major sphingomyelin synthase at the Golgi apparatus. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes. Does not use free phosphorylcholine or CDP-choline as donor. Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting. Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1. Taurus_UMD|evm.model.AC_000183.1.44 Q9UNW1 MINP1_HUMAN 79.055 0.995595 0.932238 MINPP1 - Multiple inositol polyphosphate phosphatase 1 precursor - Homo sapiens (Human) - MINPP1 gene Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity). Taurus_UMD|evm.model.AC_000183.1.45 O95340 PAPS2_HUMAN 92.782 0.979275 0.942997 PAPSS2 - Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 - Homo sapiens (Human) - PAPSS2 gene Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have an important role in skeletogenesis during postnatal growth (By similarity). Taurus_UMD|evm.model.AC_000183.1.46 F6QV99 ATAD1_BOVIN 100.000 0.994475 1.00277 ATAD1 - Outer mitochondrial transmembrane helix translocase - Bos taurus (Bovine) - ATAD1 gene Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). Taurus_UMD|evm.model.AC_000183.1.47 P60484 PTEN_HUMAN 99.752 0.99505 1.00248 PTEN - Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN - Homo sapiens (Human) - PTEN gene Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226, PubMed:16824732). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement. Taurus_UMD|evm.model.AC_000183.1.48 Q5VYX0 RNLS_HUMAN 84.795 0.994169 1.00292 RNLS - Renalase precursor - Homo sapiens (Human) - RNLS gene Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. Taurus_UMD|evm.model.AC_000183.1.49 Q5W064 LIPJ_HUMAN 81.644 0.912281 1.09016 LIPJ - Lipase member J - Homo sapiens (Human) - LIPJ gene intracellular membrane-bounded organelle Taurus_UMD|evm.model.AC_000183.1.50 P15927 RFA2_HUMAN 89.630 0.99262 1.0037 RPA2 - Replication protein A 32 kDa subunit - Homo sapiens (Human) - RPA2 gene As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. Taurus_UMD|evm.model.AC_000183.1.51 P07098 LIPG_HUMAN 85.263 0.671429 0.351759 LIPF - Gastric triacylglycerol lipase precursor - Homo sapiens (Human) - LIPF gene Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:2243091, PubMed:10358049). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (PubMed:2243091). Taurus_UMD|evm.model.AC_000183.1.52 Q5VXJ0 LIPK_HUMAN 84.635 0.994962 0.994987 LIPK - Lipase member K precursor - Homo sapiens (Human) - LIPK gene Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. Taurus_UMD|evm.model.AC_000183.1.53 Q5VXI9 LIPN_HUMAN 81.566 0.992462 1 LIPN - Lipase member N precursor - Homo sapiens (Human) - LIPN gene Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. Taurus_UMD|evm.model.AC_000183.1.54 Q5VYY2 LIPM_HUMAN 88.180 0.995283 1.00236 LIPM - Lipase member M precursor - Homo sapiens (Human) - LIPM gene Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. Taurus_UMD|evm.model.AC_000183.1.55 Q5VYY1 ANR22_HUMAN 90.000 0.984375 1.00524 ANKRD22 - Ankyrin repeat domain-containing protein 22 - Homo sapiens (Human) - ANKRD22 gene Taurus_UMD|evm.model.AC_000183.1.56 Q96FJ0 STALP_HUMAN 92.661 0.995423 1.00229 STAMBPL1 - AMSH-like protease - Homo sapiens (Human) - STAMBPL1 gene Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Taurus_UMD|evm.model.AC_000183.1.57 P62738 ACTA_RAT 100.000 0.994709 1.00265 Acta2 - Actin, aortic smooth muscle precursor - Rattus norvegicus (Rat) - Acta2 gene Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Taurus_UMD|evm.model.AC_000183.1.58 P51867 TNR6_BOVIN 100.000 0.993827 1.0031 FAS - Tumor necrosis factor receptor superfamily member 6 precursor - Bos taurus (Bovine) - FAS gene Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). Taurus_UMD|evm.model.AC_000183.1.59 Q4G1G8 CH25H_PIG 86.296 0.99262 1.0037 CH25H - Cholesterol 25-hydroxylase - Sus scrofa (Pig) - CH25H gene Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation. Taurus_UMD|evm.model.AC_000183.1.60 Q4R4S5 LICH_MACFA 82.456 0.797595 1.25063 LIPA - Lysosomal acid lipase/cholesteryl ester hydrolase precursor - Macaca fascicularis (Crab-eating macaque) - LIPA gene Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. Taurus_UMD|evm.model.AC_000183.1.61 P09913 IFIT2_HUMAN 74.034 0.691958 1.39619 IFIT2 - Interferon-induced protein with tetratricopeptide repeats 2 - Homo sapiens (Human) - IFIT2 gene IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. Taurus_UMD|evm.model.AC_000183.1.62 O14879 IFIT3_HUMAN 71.546 0.989712 0.991837 IFIT3 - Interferon-induced protein with tetratricopeptide repeats 3 - Homo sapiens (Human) - IFIT3 gene IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. Taurus_UMD|evm.model.AC_000183.1.63 Q4R5F5 IFIT1_MACFA 67.511 0.985386 1.00209 IFIT1 - Interferon-induced protein with tetratricopeptide repeats 1 - Macaca fascicularis (Crab-eating macaque) - IFIT1 gene Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism) (By similarity). Taurus_UMD|evm.model.AC_000183.1.64 Q13325 IFIT5_HUMAN 92.531 0.995859 1.00207 IFIT5 - Interferon-induced protein with tetratricopeptide repeats 5 - Homo sapiens (Human) - IFIT5 gene Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed:26334375). Taurus_UMD|evm.model.AC_000183.1.65 Q6ZSM3 MOT12_HUMAN 91.358 0.995893 0.943798 SLC16A12 - Monocarboxylate transporter 12 - Homo sapiens (Human) - SLC16A12 gene Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane. Taurus_UMD|evm.model.AC_000183.1.66 Q8TE04 PANK1_HUMAN 91.304 0.996622 0.989967 PANK1 - Pantothenate kinase 1 - Homo sapiens (Human) - PANK1 gene Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. Taurus_UMD|evm.model.AC_000183.1.67 Q96Q89 KI20B_HUMAN 81.739 0.994556 1.00934 KIF20B - Kinesin-like protein KIF20B - Homo sapiens (Human) - KIF20B gene Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). Taurus_UMD|evm.model.AC_000183.1.70 Q8N567 ZCHC9_HUMAN 93.878 0.989848 0.726937 ZCCHC9 - Zinc finger CCHC domain-containing protein 9 - Homo sapiens (Human) - ZCCHC9 gene May down-regulate transcription mediated by NF-kappa-B and the serum response element. Taurus_UMD|evm.model.AC_000183.1.72 P56602 PPOX_BOVIN 88.235 0.611399 0.404612 PPOX - Protoporphyrinogen oxidase - Bos taurus (Bovine) - PPOX gene Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Taurus_UMD|evm.model.AC_000183.1.73 Q4R7X8 ZN322_MACFA 94.195 0.881119 1.06716 ZNF322 - Zinc finger protein 322 - Macaca fascicularis (Crab-eating macaque) - ZNF322 gene Transcriptional activator. Important for maintenance of pluripotency in embryonic stem cells. Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes. Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly. Promotes inhibition of MAPK signaling during embryonic stem cell differentiation. Taurus_UMD|evm.model.AC_000183.1.74 P34969 5HT7R_HUMAN 94.495 0.995413 0.91023 HTR7 - 5-hydroxytryptamine receptor 7 - Homo sapiens (Human) - HTR7 gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. Taurus_UMD|evm.model.AC_000183.1.75 Q3SZ21 RPP30_BOVIN 99.627 0.992565 1.00373 RPP30 - Ribonuclease P protein subunit p30 - Bos taurus (Bovine) - RPP30 gene Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Taurus_UMD|evm.model.AC_000183.1.76 Q3ZBX7 ANKR1_BOVIN 100.000 0.99375 1.00313 ANKRD1 - Ankyrin repeat domain-containing protein 1 - Bos taurus (Bovine) - ANKRD1 gene May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). Taurus_UMD|evm.model.AC_000183.1.77 Q8BVU5 NUDT9_MOUSE 75.714 0.588983 0.674286 Nudt9 - ADP-ribose pyrophosphatase, mitochondrial precursor - Mus musculus (Mouse) - Nudt9 gene Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. Taurus_UMD|evm.model.AC_000183.1.78 A0JN86 PCGF5_BOVIN 99.609 0.992218 1.00784 PCGF5 - Polycomb group RING finger protein 5 - Bos taurus (Bovine) - PCGF5 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity). Taurus_UMD|evm.model.AC_000183.1.79 Q5RD78 HECD2_PONAB 92.912 0.997423 1 HECTD2 - Probable E3 ubiquitin-protein ligase HECTD2 - Pongo abelii (Sumatran orangutan) - HECTD2 gene E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Taurus_UMD|evm.model.AC_000183.1.80 Q0VCR4 PPR3C_BOVIN 100.000 0.993631 0.987421 PPP1R3C - Protein phosphatase 1 regulatory subunit 3C - Bos taurus (Bovine) - PPP1R3C gene Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types (By similarity). Taurus_UMD|evm.model.AC_000183.1.81 Q3UES3 TNKS2_MOUSE 91.798 0.863492 1.08062 Tnks2 - Poly [ADP-ribose] polymerase tankyrase-2 - Mus musculus (Mouse) - Tnks2 gene Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity. Taurus_UMD|evm.model.AC_000183.1.82 Q8TAT2 FGFP3_HUMAN 71.983 0.895349 1 FGFBP3 - Fibroblast growth factor-binding protein 3 precursor - Homo sapiens (Human) - FGFBP3 gene Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability. Taurus_UMD|evm.model.AC_000183.1.83 O14981 BTAF1_HUMAN 95.403 0.998918 1 BTAF1 - TATA-binding protein-associated factor 172 - Homo sapiens (Human) - BTAF1 gene Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner. Taurus_UMD|evm.model.AC_000183.1.84 Q8NE35 CPEB3_HUMAN 93.079 0.99708 0.981375 CPEB3 - Cytoplasmic polyadenylation element-binding protein 3 - Homo sapiens (Human) - CPEB3 gene Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195). Taurus_UMD|evm.model.AC_000183.1.85 Q3KNM2 MARH5_MOUSE 100.000 0.965854 0.73741 Marchf5 - E3 ubiquitin-protein ligase MARCHF5 - Mus musculus (Mouse) - Marchf5 gene Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. Taurus_UMD|evm.model.AC_000183.1.86 Q24K02 IDE_BOVIN 100.000 0.998039 1.00098 IDE - Insulin-degrading enzyme - Bos taurus (Bovine) - IDE gene Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling (By similarity). Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (By similarity). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP. Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (By similarity). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (By similarity). Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (By similarity). Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I (By similarity). Taurus_UMD|evm.model.AC_000183.1.87 P52732 KIF11_HUMAN 84.295 0.998081 0.986742 KIF11 - Kinesin-like protein KIF11 - Homo sapiens (Human) - KIF11 gene Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). Taurus_UMD|evm.model.AC_000183.1.88 P46405 RS12_PIG 90.625 0.940594 0.765152 RPS12 - 40S ribosomal protein S12 - Sus scrofa (Pig) - RPS12 gene cytosolic small ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000183.1.89 O19110 TSPY1_BOVIN 57.692 0.819149 0.29653 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000183.1.90 Q03014 HHEX_HUMAN 94.853 0.992647 1.00741 HHEX - Hematopoietically-expressed homeobox protein HHEX - Homo sapiens (Human) - HHEX gene Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). May play a role in hematopoietic differentiation (PubMed:8096636). Taurus_UMD|evm.model.AC_000183.1.91 E2R766 EXOC6_CANLF 95.203 0.997543 1.0137 EXOC6 - Exocyst complex component 6 - Canis lupus familiaris (Dog) - EXOC6 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane (By similarity). Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Taurus_UMD|evm.model.AC_000183.1.92 Q6V0L0 CP26C_HUMAN 89.038 0.990458 1.00383 CYP26C1 - Cytochrome P450 26C1 - Homo sapiens (Human) - CYP26C1 gene Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate). Taurus_UMD|evm.model.AC_000183.1.93 O55127 CP26A_MOUSE 94.567 0.995984 1.00201 Cyp26a1 - Cytochrome P450 26A1 - Mus musculus (Mouse) - Cyp26a1 gene A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 and C-18 (PubMed:9250660, PubMed:9442090). Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers. May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (By similarity). Taurus_UMD|evm.model.AC_000183.1.94 Q9NZM1 MYOF_HUMAN 93.304 0.99903 1 MYOF - Myoferlin - Homo sapiens (Human) - MYOF gene Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). Taurus_UMD|evm.model.AC_000183.1.95 Q53EZ4 CEP55_HUMAN 85.345 0.99569 1 CEP55 - Centrosomal protein of 55 kDa - Homo sapiens (Human) - CEP55 gene Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). Taurus_UMD|evm.model.AC_000183.1.96 C8YUV0 FFAR4_MACFA 85.596 0.994475 1.00277 FFAR4 - Free fatty acid receptor 4 - Macaca fascicularis (Crab-eating macaque) - FFAR4 gene G-protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G-protein and beta-arrestin pathways. LCFAs sensing initiates activation of phosphoinositidase C-linked G proteins GNAQ and GNA11 (G(q)/G(11)), inducing a variety of cellular responses via second messenger pathways such as intracellular calcium mobilization, modulation of cyclic adenosine monophosphate (cAMP) production, and mitogen-activated protein kinases (MAPKs). After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (By similarity). In response to dietary fats, plays an important role in the regulation of adipocyte proliferation and differentiation. Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that ultimately results in transcriptional activation of adipogenic genes and cell cycle entry. Induces differentiation of brown and beige adipocytes probably via autocrine and endocrine functions of FGF21 hormone. Contributes to the thermogenic activation of brown adipose tissue and the browning of white adipose tissue. Activates brown adipocytes by initiating intracellular calcium signaling leading to mitochondrial depolarization and fission, and overall increased mitochondrial respiration. Consequently stimulates fatty acid uptake and oxidation in mitochondria together with UCP1-mediated thermogenic respiration, eventually reducing fat mass. Regulates bi-potential differentiation of bone marrow mesenchymal stem cells toward osteoblasts or adipocytes likely by up-regulating distinct integrins. In response to dietary fats regulates hormone secretion and appetite. Stimulates GIP and GLP1 secretion from enteroendocrine cells as well as GCG secretion in pancreatic alpha cells, thereby playing a role in the regulation of blood glucose levels. Negatively regulates glucose-induced SST secretion in pancreatic delta cells. Mediates LCFAs inhibition of GHRL secretion, an appetite-controlling hormone. In taste buds, contributes to sensing of dietary fatty acids by the gustatory system. During the inflammatory response, promotes anti-inflammatory M2 macrophage differentiation in adipose tissue (By similarity). Mediates the anti-inflammatory effects of omega-3 PUFAs via inhibition of NLRP3 inflammasome activation (By similarity). In this pathway, interacts with adapter protein ARRB2 and inhibits the priming step triggered by Toll-like receptors (TLRs) at the level of TAK1 and TAB1 (By similarity). Further inhibits the activation step when ARRB2 directly associates with NLRP3, leading to inhibition of proinflammatory cytokine release (By similarity). Mediates LCFAs anti-apoptotic effects (By similarity). Taurus_UMD|evm.model.AC_000183.1.97 P18902 RET4_BOVIN 100.000 0.90099 1.10383 RBP4 - Retinol-binding protein 4 - Bos taurus (Bovine) - RBP4 gene Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. Taurus_UMD|evm.model.AC_000183.1.98 P16586 PDE6C_BOVIN 99.766 0.997664 1.00117 PDE6C - Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' precursor - Bos taurus (Bovine) - PDE6C gene As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. Taurus_UMD|evm.model.AC_000183.1.99 Q70Z53 F10C1_HUMAN 92.063 0.993671 1.00317 FRA10AC1 - Protein FRA10AC1 - Homo sapiens (Human) - FRA10AC1 gene phosphatase activity, dephosphorylation Taurus_UMD|evm.model.AC_000183.1.100 Q5E9T6 LGI1_BOVIN 100.000 0.664804 0.335835 LGI1 - Leucine-rich glioma-inactivated protein 1 precursor - Bos taurus (Bovine) - LGI1 gene Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity). Taurus_UMD|evm.model.AC_000183.1.101 Q5E9T6 LGI1_BOVIN 98.810 0.750896 1.0469 LGI1 - Leucine-rich glioma-inactivated protein 1 precursor - Bos taurus (Bovine) - LGI1 gene Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity). Taurus_UMD|evm.model.AC_000183.1.102 Q2M3R5 S35G1_HUMAN 75.342 0.994536 1.00274 SLC35G1 - Solute carrier family 35 member G1 - Homo sapiens (Human) - SLC35G1 gene May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell. Taurus_UMD|evm.model.AC_000183.1.103 Q9P212 PLCE1_HUMAN 76.675 0.915525 0.190269 PLCE1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 - Homo sapiens (Human) - PLCE1 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downtream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690). Taurus_UMD|evm.model.AC_000183.1.104 Q9P212 PLCE1_HUMAN 91.851 0.996844 0.825804 PLCE1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 - Homo sapiens (Human) - PLCE1 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downtream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690). Taurus_UMD|evm.model.AC_000183.1.105 Q8WTT2 NOC3L_HUMAN 92.866 0.99625 1 NOC3L - Nucleolar complex protein 3 homolog - Homo sapiens (Human) - NOC3L gene May be required for adipogenesis. Taurus_UMD|evm.model.AC_000183.1.106 O60347 TBC12_HUMAN 87.130 0.997375 0.983226 TBC1D12 - TBC1 domain family member 12 - Homo sapiens (Human) - TBC1D12 gene RAB11A-binding protein that plays a role in neurite outgrowth. Taurus_UMD|evm.model.AC_000183.1.107 Q9NRZ9 HELLS_HUMAN 94.140 0.997452 0.936754 HELLS - Lymphoid-specific helicase - Homo sapiens (Human) - HELLS gene Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). Taurus_UMD|evm.model.AC_000183.1.108 P33260 CP2CI_HUMAN 78.163 0.995825 0.977551 CYP2C18 - Cytochrome P450 2C18 precursor - Homo sapiens (Human) - CYP2C18 gene A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Taurus_UMD|evm.model.AC_000183.1.109 P33260 CP2CI_HUMAN 59.388 0.995134 0.838776 CYP2C18 - Cytochrome P450 2C18 precursor - Homo sapiens (Human) - CYP2C18 gene A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Taurus_UMD|evm.model.AC_000183.1.110 P33260 CP2CI_HUMAN 78.252 0.995943 1.00612 CYP2C18 - Cytochrome P450 2C18 precursor - Homo sapiens (Human) - CYP2C18 gene A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Taurus_UMD|evm.model.AC_000183.1.111 P33263 CP2CQ_MESAU 75.824 0.967742 0.189796 CYP2C26 - Cytochrome P450 2C26 - Mesocricetus auratus (Golden hamster) - CYP2C26 gene Catalyzes the hydroxylation of tolbutamide and the N-demethylation of aminopyrine and benzphetamine. Taurus_UMD|evm.model.AC_000183.1.112 P11712 CP2C9_HUMAN 78.132 0.957055 0.997959 CYP2C9 - Cytochrome P450 2C9 - Homo sapiens (Human) - CYP2C9 gene A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:7574697, PubMed:15766564, PubMed:19965576, PubMed:9866708). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) (PubMed:9866708, PubMed:9435160). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031). Taurus_UMD|evm.model.AC_000183.1.113 P33260 CP2CI_HUMAN 70.000 0.995465 0.9 CYP2C18 - Cytochrome P450 2C18 precursor - Homo sapiens (Human) - CYP2C18 gene A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Taurus_UMD|evm.model.AC_000183.1.114 P56594 CP2CL_CANLF 78.472 0.350122 2.52772 CYP2C21 - Cytochrome P450 2C21 - Canis lupus familiaris (Dog) - CYP2C21 gene Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Showed testosterone hydrolase activity. Taurus_UMD|evm.model.AC_000183.1.115 Q5E9E1 PDLI1_BOVIN 99.695 0.993921 1.00305 PDLIM1 - PDZ and LIM domain protein 1 - Bos taurus (Bovine) - PDLIM1 gene Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (By similarity). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). Taurus_UMD|evm.model.AC_000183.1.117 Q9BX66 SRBS1_HUMAN 97.500 0.0956416 0.639319 SORBS1 - Sorbin and SH3 domain-containing protein 1 - Homo sapiens (Human) - SORBS1 gene Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). Taurus_UMD|evm.model.AC_000183.1.118 Q5R4M8 P5CS_PONAB 97.484 0.997487 1.00126 ALDH18A1 - Delta-1-pyrroline-5-carboxylate synthase - Pongo abelii (Sumatran orangutan) - ALDH18A1 gene Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. Taurus_UMD|evm.model.AC_000183.1.119 Q6NUS6 TECT3_HUMAN 80.405 0.971667 0.988468 TCTN3 - Tectonic-3 precursor - Homo sapiens (Human) - TCTN3 gene Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway. Taurus_UMD|evm.model.AC_000183.1.120 O18956 ENTP1_BOVIN 98.821 0.965779 1.02534 ENTPD1 - Ectonucleoside triphosphate diphosphohydrolase 1 - Bos taurus (Bovine) - ENTPD1 gene In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. Taurus_UMD|evm.model.AC_000183.1.121 Q6DHV5 C2D2B_HUMAN 79.889 0.998588 0.985386 CC2D2B - Protein CC2D2B - Homo sapiens (Human) - CC2D2B gene Taurus_UMD|evm.model.AC_000183.1.122 Q5T5M9 CCNJ_HUMAN 93.995 0.994792 1.03226 CCNJ - Cyclin-J - Homo sapiens (Human) - CCNJ gene centrosome, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus, cyclin-dependent protein serine/threonine kinase regulator activity, mitotic cell cycle phase transition, regulation of cyclin-dependent protein serine/threonine kinase activity Taurus_UMD|evm.model.AC_000183.1.123 Q6AHZ1 Z518A_HUMAN 78.362 0.998651 1 ZNF518A - Zinc finger protein 518A - Homo sapiens (Human) - ZNF518A gene Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes. Taurus_UMD|evm.model.AC_000183.1.124 Q8WV28 BLNK_HUMAN 88.671 0.995652 1.00877 BLNK - B-cell linker protein - Homo sapiens (Human) - BLNK gene Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. Taurus_UMD|evm.model.AC_000183.1.125 P06526 TDT_BOVIN 100.000 0.996078 1.00196 DNTT - DNA nucleotidylexotransferase - Bos taurus (Bovine) - DNTT gene Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator (PubMed:3755527). One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. Taurus_UMD|evm.model.AC_000183.1.126 Q29102 OPALI_PIG 85.915 0.986014 1.00704 OPALIN - Opalin - Sus scrofa (Pig) - OPALIN gene Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation. Taurus_UMD|evm.model.AC_000183.1.127 Q9Y6L7 TLL2_HUMAN 91.667 0.998041 1.00591 TLL2 - Tolloid-like protein 2 precursor - Homo sapiens (Human) - TLL2 gene Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. Taurus_UMD|evm.model.AC_000183.1.129 Q9ET30 TM9S3_MOUSE 99.830 0.996599 1.0017 Tm9sf3 - Transmembrane 9 superfamily member 3 precursor - Mus musculus (Mouse) - Tm9sf3 gene membrane, protein localization to membrane Taurus_UMD|evm.model.AC_000183.1.130 Q6ZUJ8 BCAP_HUMAN 94.175 0.990338 0.257143 PIK3AP1 - Phosphoinositide 3-kinase adapter protein 1 - Homo sapiens (Human) - PIK3AP1 gene Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. Taurus_UMD|evm.model.AC_000183.1.131 Q6ZUJ8 BCAP_HUMAN 89.048 0.985765 0.698137 PIK3AP1 - Phosphoinositide 3-kinase adapter protein 1 - Homo sapiens (Human) - PIK3AP1 gene Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. Taurus_UMD|evm.model.AC_000183.1.132 Q96JN0 LCOR_HUMAN 99.307 0.685714 1.45497 LCOR - Ligand-dependent corepressor - Homo sapiens (Human) - LCOR gene May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. Taurus_UMD|evm.model.AC_000183.1.133 Q3TNU4 YD021_MOUSE 30.409 0.113683 2.51541 Gm3414 - Putative uncharacterized protein ENSP00000382790 homolog - Mus musculus (Mouse) - Gm3414 gene Taurus_UMD|evm.model.AC_000183.1.134 O75093 SLIT1_HUMAN 93.937 0.998697 1.00065 SLIT1 - Slit homolog 1 protein precursor - Homo sapiens (Human) - SLIT1 gene Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. Taurus_UMD|evm.model.AC_000183.1.135 Q14CB8 RHG19_HUMAN 92.683 0.995943 0.997976 ARHGAP19 - Rho GTPase-activating protein 19 - Homo sapiens (Human) - ARHGAP19 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000183.1.136 Q92837 FRAT1_HUMAN 81.786 0.992754 0.989247 FRAT1 - Proto-oncogene FRAT1 - Homo sapiens (Human) - FRAT1 gene Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis. Taurus_UMD|evm.model.AC_000183.1.137 O75474 FRAT2_HUMAN 79.741 0.986957 0.987124 FRAT2 - GSK-3-binding protein FRAT2 - Homo sapiens (Human) - FRAT2 gene Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. Taurus_UMD|evm.model.AC_000183.1.138 Q5JTH9 RRP12_HUMAN 90.776 0.998459 1.00077 RRP12 - RRP12-like protein - Homo sapiens (Human) - RRP12 gene cytosol, intracellular membrane-bounded organelle, nucleolus, plasma membrane, RNA binding, rRNA processing Taurus_UMD|evm.model.AC_000183.1.139 Q3SZ62 PGAM1_BOVIN 100.000 0.992157 1.00394 PGAM1 - Phosphoglycerate mutase 1 - Bos taurus (Bovine) - PGAM1 gene Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. Taurus_UMD|evm.model.AC_000183.1.140 Q9DAA6 EXOS1_MOUSE 96.923 0.779116 1.27692 Exosc1 - Exosome complex component CSL4 - Mus musculus (Mouse) - Exosc1 gene Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8 (By similarity). Taurus_UMD|evm.model.AC_000183.1.141 Q58CU4 ZDH16_BOVIN 100.000 0.994709 1.00265 ZDHHC16 - Palmitoyltransferase ZDHHC16 - Bos taurus (Bovine) - ZDHHC16 gene Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (By similarity). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity). Taurus_UMD|evm.model.AC_000183.1.142 E1BP36 MMS19_BOVIN 99.806 0.998058 1 MMS19 - MMS19 nucleotide excision repair protein homolog - Bos taurus (Bovine) - MMS19 gene Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target Fe/S proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription. As a CIA complex component and in collaboration with CIAO1 and CIAO2, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery. Taurus_UMD|evm.model.AC_000183.1.143 Q3ZBQ1 UBTD1_BOVIN 100.000 0.991228 1.00441 UBTD1 - Ubiquitin domain-containing protein 1 - Bos taurus (Bovine) - UBTD1 gene May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2. Taurus_UMD|evm.model.AC_000183.1.144 Q9GZV1 ANKR2_HUMAN 89.970 0.993939 0.916667 ANKRD2 - Ankyrin repeat domain-containing protein 2 - Homo sapiens (Human) - ANKRD2 gene Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. Taurus_UMD|evm.model.AC_000183.1.145 Q0P5I5 HOGA1_BOVIN 100.000 0.993902 1.00306 HOGA1 - 4-hydroxy-2-oxoglutarate aldolase, mitochondrial precursor - Bos taurus (Bovine) - HOGA1 gene Catalyzes the final step in the metabolic pathway of hydroxyproline. Taurus_UMD|evm.model.AC_000183.1.146 Q0VD26 MORN4_BOVIN 100.000 0.986395 1.00685 MORN4 - MORN repeat-containing protein 4 - Bos taurus (Bovine) - MORN4 gene Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. Taurus_UMD|evm.model.AC_000183.1.147 Q9BTU6 P4K2A_HUMAN 97.912 0.995833 1.00209 PI4K2A - Phosphatidylinositol 4-kinase type 2-alpha - Homo sapiens (Human) - PI4K2A gene Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Taurus_UMD|evm.model.AC_000183.1.148 Q3SZR0 AVPI1_BOVIN 100.000 0.986207 1.00694 AVPI1 - Arginine vasopressin-induced protein 1 - Bos taurus (Bovine) - AVPI1 gene May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling. Taurus_UMD|evm.model.AC_000183.1.150 Q7TQJ1 MALD1_MOUSE 88.372 0.982759 1.00578 Marveld1 - MARVEL domain-containing protein 1 - Mus musculus (Mouse) - Marveld1 gene Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration. Taurus_UMD|evm.model.AC_000183.1.151 Q5BIM5 ZFY27_BOVIN 100.000 0.980535 1.01733 ZFYVE27 - Protrudin - Bos taurus (Bovine) - ZFYVE27 gene Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner. Taurus_UMD|evm.model.AC_000183.1.152 Q9XSC1 SFRP5_BOVIN 100.000 0.993671 1.00317 SFRP5 - Secreted frizzled-related protein 5 precursor - Bos taurus (Bovine) - SFRP5 gene Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps other, cells in the retina. Inhibits Wnt8 signaling, in vitro. Taurus_UMD|evm.model.AC_000183.1.153 Q2TAP0 GOG7B_HUMAN 98.171 0.730942 1.33533 GOLGA7B - Golgin subfamily A member 7B - Homo sapiens (Human) - GOLGA7B gene May be involved in protein transport from Golgi to cell surface. Taurus_UMD|evm.model.AC_000183.1.155 Q7Z5L2 R3HCL_HUMAN 70.787 0.997459 0.993687 R3HCC1L - Coiled-coil domain-containing protein R3HCC1L - Homo sapiens (Human) - R3HCC1L gene Taurus_UMD|evm.model.AC_000183.1.156 Q8MJ24 LOXL4_BOVIN 100.000 0.996226 0.700132 LOXL4 - Lysyl oxidase homolog 4 precursor - Bos taurus (Bovine) - LOXL4 gene May modulate the formation of a collagenous extracellular matrix. Taurus_UMD|evm.model.AC_000183.1.157 Q8MJ24 LOXL4_BOVIN 99.556 0.864341 0.340819 LOXL4 - Lysyl oxidase homolog 4 precursor - Bos taurus (Bovine) - LOXL4 gene May modulate the formation of a collagenous extracellular matrix. Taurus_UMD|evm.model.AC_000183.1.158 Q3MHH6 PYRD2_BOVIN 99.656 0.996564 1.00172 PYROXD2 - Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 - Bos taurus (Bovine) - PYROXD2 gene Probable oxidoreductase that may play a role as regulator of mitochondrial function. Taurus_UMD|evm.model.AC_000183.1.159 Q92902 HPS1_HUMAN 82.370 0.95283 1.06 HPS1 - Hermansky-Pudlak syndrome 1 protein - Homo sapiens (Human) - HPS1 gene Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991). Taurus_UMD|evm.model.AC_000183.1.160 Q8WWQ2 HPSE2_HUMAN 99.742 0.994859 0.657095 HPSE2 - Inactive heparanase-2 precursor - Homo sapiens (Human) - HPSE2 gene Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). Taurus_UMD|evm.model.AC_000183.1.162 Q0GA42 CNNM1_MOUSE 97.115 0.599307 0.91062 Cnnm1 - Metal transporter CNNM1 - Mus musculus (Mouse) - Cnnm1 gene Probable metal transporter. Taurus_UMD|evm.model.AC_000183.1.163 P33097 AATC_BOVIN 100.000 0.995169 1.00242 GOT1 - Aspartate aminotransferase, cytoplasmic - Bos taurus (Bovine) - GOT1 gene Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity). Taurus_UMD|evm.model.AC_000183.1.164 Q8TAU0 NKX23_HUMAN 91.826 0.994565 1.01099 NKX2-3 - Homeobox protein Nkx-2.3 - Homo sapiens (Human) - NKX2-3 gene Transcription factor. Taurus_UMD|evm.model.AC_000183.1.165 Q96A46 MFRN2_HUMAN 98.352 0.994521 1.00275 SLC25A28 - Mitoferrin-2 - Homo sapiens (Human) - SLC25A28 gene Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). Taurus_UMD|evm.model.AC_000183.1.166 Q9NQZ7 ENTP7_HUMAN 86.064 0.951825 1.13411 ENTPD7 - Ectonucleoside triphosphate diphosphohydrolase 7 - Homo sapiens (Human) - ENTPD7 gene Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Preferentially hydrolyzes nucleoside 5'-triphosphates, with substrate preference for UTP > GTP > CTP. Hydrolyzes ATP and nucleoside diphosphates only to a minor extent. Taurus_UMD|evm.model.AC_000183.1.167 Q08DG6 COX15_BOVIN 100.000 0.995169 1.00242 COX15 - Cytochrome c oxidase assembly protein COX15 homolog - Bos taurus (Bovine) - COX15 gene May be involved in the biosynthesis of heme A. Taurus_UMD|evm.model.AC_000183.1.168 Q9NTM9 CUTC_HUMAN 95.971 0.992701 1.00366 CUTC - Copper homeostasis protein cutC homolog - Homo sapiens (Human) - CUTC gene May play a role in copper homeostasis. Can bind one Cu(1+) per subunit. Taurus_UMD|evm.model.AC_000183.1.169 Q92887 MRP2_HUMAN 77.904 0.998623 0.939806 ABCC2 - ATP-binding cassette sub-family C member 2 - Homo sapiens (Human) - ABCC2 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transport various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505). Taurus_UMD|evm.model.AC_000183.1.170 Q6XZF7 DNMBP_HUMAN 90.953 0.682684 0.765377 DNMBP - Dynamin-binding protein - Homo sapiens (Human) - DNMBP gene Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:19767742, PubMed:17015620). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). Taurus_UMD|evm.model.AC_000183.1.171 Q6XZF7 DNMBP_HUMAN 76.903 0.976864 0.493342 DNMBP - Dynamin-binding protein - Homo sapiens (Human) - DNMBP gene Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:19767742, PubMed:17015620). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). Taurus_UMD|evm.model.AC_000183.1.172 Q2KJ83 CBPN_BOVIN 99.784 0.99568 1.00216 CPN1 - Carboxypeptidase N catalytic chain precursor - Bos taurus (Bovine) - CPN1 gene Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. Taurus_UMD|evm.model.AC_000183.1.173 P24470 CP2CN_RAT 73.535 0.995968 1.00405 Cyp2c23 - Cytochrome P450 2C23 - Rattus norvegicus (Rat) - Cyp2c23 gene A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonic acid (ARA, C20:4(n-6)) primarily to stereospecific products 8R,9S-, 11R,12S-, and 14S,15R-EET (PubMed:8246128, PubMed:14742258, PubMed:10491410). Plays a major role in the formation of EETs and hydroxy-EETs (HEETs) in kidney (PubMed:10491410, PubMed:14742258). Via EETs may inhibit the epithelial sodium channels (ENaCs) in nephron segments, preventing excessive sodium absorption during high dietary salt intake (By similarity). Participates in the formation of anti-inflammatory hydroxyepoxyeicosatrienoic acids (HEETs) by converting 20-hydroxyeicosatetraenoic acid (20-HETE) to 20,8,9-HEET, an activator of PPARA (PubMed:14742258). Metabolizes eicosapentaenoic acid (EPA, C20:5(n-3)) to epoxyeicosatetraenoic acid (EETeTr) regioisomers, 8,9-, 11,12-, 14,15-, and 17,18-EETeTr, preferentially producing 17R,18S enantiomer (PubMed:15766564). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8246128). Taurus_UMD|evm.model.AC_000183.1.174 O75477 ERLN1_HUMAN 95.677 0.991404 1.00287 ERLIN1 - Erlin-1 - Homo sapiens (Human) - ERLIN1 gene Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618). Taurus_UMD|evm.model.AC_000183.1.175 Q95KV1 IKKA_BOVIN 100.000 0.953548 1.0473 CHUK - Inhibitor of nuclear factor kappa-B kinase subunit alpha - Bos taurus (Bovine) - CHUK gene Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor. Interacts with SASH1 (By similarity). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Taurus_UMD|evm.model.AC_000183.1.176 Q32WR5 BL1S2_RAT 96.183 0.185449 4.93662 Bloc1s2 - Biogenesis of lysosome-related organelles complex-1 subunit 2 - Rattus norvegicus (Rat) - Bloc1s2 gene Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation. Taurus_UMD|evm.model.AC_000183.1.177 Q32LL9 CENPN_BOVIN 99.410 0.994118 1.00295 CENPN - Centromere protein N - Bos taurus (Bovine) - CENPN gene Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. Taurus_UMD|evm.model.AC_000183.1.178 Q9P0L9 PK2L1_HUMAN 89.763 0.975362 0.857143 PKD2L1 - Polycystic kidney disease 2-like 1 protein - Homo sapiens (Human) - PKD2L1 gene Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed:10517637, PubMed:11959145, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:23212381, PubMed:30004384). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration (PubMed:24336289). The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289). Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells (PubMed:19812697). The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again (PubMed:23212381). May play a role in the perception of carbonation taste (By similarity). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (By similarity). Taurus_UMD|evm.model.AC_000183.1.179 Q9TT94 SCD_BOVIN 84.483 0.228 0.696379 SCD - Stearoyl-CoA desaturase - Bos taurus (Bovine) - SCD gene Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). Taurus_UMD|evm.model.AC_000183.1.180 Q9TT94 SCD_BOVIN 99.609 0.913978 0.777159 SCD - Stearoyl-CoA desaturase - Bos taurus (Bovine) - SCD gene Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). Taurus_UMD|evm.model.AC_000183.1.181 P31291 WNT8B_XENLA 94.737 0.151351 0.864486 wnt8b - Protein Wnt-8b precursor - Xenopus laevis (African clawed frog) - wnt8b gene Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in the initiation of dorsal axis development. May activate a Nieuwkoop center-like signaling pathway. Taurus_UMD|evm.model.AC_000183.1.182 Q9NQW1 SC31B_HUMAN 83.206 0.998279 0.985581 SEC31B - Protein transport protein Sec31B - Homo sapiens (Human) - SEC31B gene As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum. Taurus_UMD|evm.model.AC_000183.1.184 Q02372 NDUB8_BOVIN 100.000 0.989305 1.00538 NDUFB8 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor - Bos taurus (Bovine) - NDUFB8 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000183.1.185 Q9NWT6 HIF1N_HUMAN 97.135 0.994286 1.00287 HIF1AN - Hypoxia-inducible factor 1-alpha inhibitor - Homo sapiens (Human) - HIF1AN gene Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. Taurus_UMD|evm.model.AC_000183.1.186 Q02962 PAX2_HUMAN 93.671 0.84127 1.05755 PAX2 - Paired box protein Pax-2 - Homo sapiens (Human) - PAX2 gene Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS. Taurus_UMD|evm.model.AC_000183.1.187 Q8IX21 SLF2_HUMAN 88.085 0.998288 0.995737 SLF2 - SMC5-SMC6 complex localization factor protein 2 - Homo sapiens (Human) - SLF2 gene Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Taurus_UMD|evm.model.AC_000183.1.188 Q9NTN9 SEM4G_HUMAN 91.943 0.997633 1.00835 SEMA4G - Semaphorin-4G precursor - Homo sapiens (Human) - SEMA4G gene Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity). Taurus_UMD|evm.model.AC_000183.1.189 Q95KE5 RM43_BOVIN 100.000 0.9875 1.00629 MRPL43 - 39S ribosomal protein L43, mitochondrial precursor - Bos taurus (Bovine) - MRPL43 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000183.1.190 Q96RR1 PEO1_HUMAN 88.889 0.997076 1 TWNK - Twinkle protein, mitochondrial precursor - Homo sapiens (Human) - TWNK gene Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals. Taurus_UMD|evm.model.AC_000183.1.191 A5PKL7 LZTS2_BOVIN 99.850 0.997006 1.0015 LZTS2 - Leucine zipper putative tumor suppressor 2 - Bos taurus (Bovine) - LZTS2 gene Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Taurus_UMD|evm.model.AC_000183.1.192 Q9H5P4 PDZD7_HUMAN 88.367 0.997934 0.937076 PDZD7 - PDZ domain-containing protein 7 - Homo sapiens (Human) - PDZD7 gene In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1. Taurus_UMD|evm.model.AC_000183.1.193 A6QP55 SFXN3_BOVIN 100.000 0.993789 1.00312 SFXN3 - Sideroflexin-3 - Bos taurus (Bovine) - SFXN3 gene Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Taurus_UMD|evm.model.AC_000183.1.194 Q96I82 KAZD1_HUMAN 93.478 0.901639 1.00329 KAZALD1 - Kazal-type serine protease inhibitor domain-containing protein 1 precursor - Homo sapiens (Human) - KAZALD1 gene Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly (By similarity). Taurus_UMD|evm.model.AC_000183.1.195 P31314 TLX1_HUMAN 93.134 0.994048 1.01818 TLX1 - T-cell leukemia homeobox protein 1 - Homo sapiens (Human) - TLX1 gene Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. Taurus_UMD|evm.model.AC_000183.1.198 P52955 LBX1_MOUSE 97.518 0.992933 1.00355 Lbx1 - Transcription factor LBX1 - Mus musculus (Mouse) - Lbx1 gene Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord. Taurus_UMD|evm.model.AC_000183.1.199 Q9Y297 FBW1A_HUMAN 99.669 0.913767 1.09256 BTRC - F-box/WD repeat-containing protein 1A - Homo sapiens (Human) - BTRC gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:25503564, PubMed:25704143, PubMed:9859996, PubMed:22087322). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14681206, PubMed:14603323). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169, PubMed:10644755). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25704143, PubMed:25503564). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 (PubMed:16371461). Mediates ubiquitination of REST, thereby leading to its proteasomal degradation (PubMed:21258371, PubMed:18354482). Taurus_UMD|evm.model.AC_000183.1.200 Q9UGP5 DPOLL_HUMAN 85.043 0.996528 1.00174 POLL - DNA polymerase lambda - Homo sapiens (Human) - POLL gene DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10982892, PubMed:10887191, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195). Taurus_UMD|evm.model.AC_000183.1.201 Q24K21 DPCD_BOVIN 100.000 0.990196 1.00493 DPCD - Protein DPCD - Bos taurus (Bovine) - DPCD gene May play a role in the formation or function of ciliated cells. Taurus_UMD|evm.model.AC_000183.1.202 P57775 FBXW4_HUMAN 96.429 0.693262 1.36893 FBXW4 - F-box/WD repeat-containing protein 4 - Homo sapiens (Human) - FBXW4 gene Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling. Taurus_UMD|evm.model.AC_000183.1.203 P55075 FGF8_HUMAN 94.672 0.991837 1.0515 FGF8 - Fibroblast growth factor 8 precursor - Homo sapiens (Human) - FGF8 gene Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111). Taurus_UMD|evm.model.AC_000183.1.204 Q5RC37 NPM3_PONAB 72.781 0.910959 0.811111 NPM3 - Nucleoplasmin-3 - Pongo abelii (Sumatran orangutan) - NPM3 gene Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning. Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM. Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM. Taurus_UMD|evm.model.AC_000183.1.205 O60502 OGA_HUMAN 99.017 0.997819 1.00109 OGA - Protein O-GlcNAcase - Homo sapiens (Human) - OGA gene Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). Taurus_UMD|evm.model.AC_000183.1.206 Q9NS61 KCIP2_HUMAN 98.889 0.99262 1.0037 KCNIP2 - Kv channel-interacting protein 2 - Homo sapiens (Human) - KCNIP2 gene Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity). Taurus_UMD|evm.model.AC_000183.1.207 Q5T2E6 ARMD3_HUMAN 99.571 0.995717 0.677794 ARMH3 - Armadillo-like helical domain-containing protein 3 - Homo sapiens (Human) - ARMH3 gene Involved in GBF1 recruitment, Golgi maintenance and protein secretion. Taurus_UMD|evm.model.AC_000183.1.208 Q86YV9 HPS6_HUMAN 86.370 0.950125 1.03484 HPS6 - Hermansky-Pudlak syndrome 6 protein - Homo sapiens (Human) - HPS6 gene May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules (PubMed:17041891). Acts as cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning (PubMed:25189619). Taurus_UMD|evm.model.AC_000183.1.209 P70662 LDB1_MOUSE 100.000 0.994536 0.890511 Ldb1 - LIM domain-binding protein 1 - Mus musculus (Mouse) - Ldb1 gene Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. Taurus_UMD|evm.model.AC_000183.1.211 Q5VV67 PPRC1_HUMAN 81.261 0.990775 0.977163 PPRC1 - Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 - Homo sapiens (Human) - PPRC1 gene Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. Taurus_UMD|evm.model.AC_000183.1.212 Q14978 NOLC1_HUMAN 78.107 0.997139 1 NOLC1 - Nucleolar and coiled-body phosphoprotein 1 - Homo sapiens (Human) - NOLC1 gene Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). Taurus_UMD|evm.model.AC_000183.1.213 Q9HB03 ELOV3_HUMAN 75.556 0.99262 1.0037 ELOVL3 - Elongation of very long chain fatty acids protein 3 - Homo sapiens (Human) - ELOVL3 gene Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Taurus_UMD|evm.model.AC_000183.1.214 O35160 PITX3_MOUSE 97.020 0.912121 1.09272 Pitx3 - Pituitary homeobox 3 - Mus musculus (Mouse) - Pitx3 gene Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle. Taurus_UMD|evm.model.AC_000183.1.215 Q92538 GBF1_HUMAN 95.325 0.998924 0.999462 GBF1 - Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 - Homo sapiens (Human) - GBF1 gene Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:16926190, PubMed:17956946, PubMed:18003980, PubMed:12047556, PubMed:12808027, PubMed:19039328, PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adapter protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (PubMed:23386609). Has GEF activity towards ARF1 (PubMed:15616190). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027, PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581, PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (PubMed:19461073, PubMed:22185782). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891). Plays a role in maintaining mitochondrial morphology (PubMed:25190516). Taurus_UMD|evm.model.AC_000183.1.216 Q00653 NFKB2_HUMAN 88.346 0.997719 0.974444 NFKB2 - Nuclear factor NF-kappa-B p100 subunit - Homo sapiens (Human) - NFKB2 gene NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Taurus_UMD|evm.model.AC_000183.1.217 F1MUS9 PSD1_BOVIN 97.076 0.997994 0.971735 PSD - PH and SEC7 domain-containing protein 1 - Bos taurus (Bovine) - PSD gene Guanine nucleotide exchange factor for ARF6 (By similarity). Induces cytoskeletal remodeling (By similarity). Taurus_UMD|evm.model.AC_000183.1.218 E1BNS0 FXL15_BOVIN 100.000 0.993355 1.00333 FBXL15 - F-box/LRR-repeat protein 15 - Bos taurus (Bovine) - FBXL15 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Taurus_UMD|evm.model.AC_000183.1.219 Q3ZBN4 CUED2_BOVIN 82.686 0.991525 0.833922 CUEDC2 - CUE domain-containing protein 2 - Bos taurus (Bovine) - CUEDC2 gene Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation. Taurus_UMD|evm.model.AC_000183.1.221 Q58CT4 MF13A_BOVIN 100.000 0.996139 1.00193 MFSD13A - Transmembrane protein 180 - Bos taurus (Bovine) - MFSD13A gene Taurus_UMD|evm.model.AC_000183.1.222 P85515 ACTZ_RAT 100.000 0.994695 1.00266 Actr1a - Alpha-centractin - Rattus norvegicus (Rat) - Actr1a gene Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity). Taurus_UMD|evm.model.AC_000183.1.224 Q9BZR9 TRIM8_HUMAN 99.274 0.996377 1.00181 TRIM8 - E3 ubiquitin-protein ligase TRIM8 - Homo sapiens (Human) - TRIM8 gene E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response (PubMed:27981609, PubMed:28747347). Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497). Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (PubMed:22084099, PubMed:23152791, PubMed:27981609). Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (PubMed:20516148). Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction (PubMed:28747347). Taurus_UMD|evm.model.AC_000183.1.225 Q2TBW6 ARL3_BOVIN 100.000 0.989071 1.00549 ARL3 - ADP-ribosylation factor-like protein 3 - Bos taurus (Bovine) - ARL3 gene Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity). Taurus_UMD|evm.model.AC_000183.1.227 Q5EA43 SFXN2_BOVIN 100.000 0.993808 1.00311 SFXN2 - Sideroflexin-2 - Bos taurus (Bovine) - SFXN2 gene Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. Taurus_UMD|evm.model.AC_000183.1.228 Q9NX94 WBP1L_HUMAN 86.765 0.918699 1.07895 WBP1L - WW domain binding protein 1-like - Homo sapiens (Human) - WBP1L gene Taurus_UMD|evm.model.AC_000183.1.229 P05185 CP17A_BOVIN 99.409 0.887916 1.12181 CYP17A1 - Steroid 17-alpha-hydroxylase/17,20 lyase - Bos taurus (Bovine) - CYP17A1 gene A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Taurus_UMD|evm.model.AC_000183.1.230 Q2KIB7 BORC7_BOVIN 100.000 0.18872 4.39048 BORCS7 - BLOC-1-related complex subunit 7 - Bos taurus (Bovine) - BORCS7 gene As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Taurus_UMD|evm.model.AC_000183.1.231 Q9H8M5 CNNM2_HUMAN 96.114 0.997658 0.976 CNNM2 - Metal transporter CNNM2 - Homo sapiens (Human) - CNNM2 gene Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). Taurus_UMD|evm.model.AC_000183.1.232 O46411 5NTC_BOVIN 100.000 0.996435 1.00179 NT5C2 - Cytosolic purine 5'-nucleotidase - Bos taurus (Bovine) - NT5C2 gene May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. Taurus_UMD|evm.model.AC_000183.1.233 Q08DH7 AINX_BOVIN 100.000 0.996 1.002 INA - Alpha-internexin - Bos taurus (Bovine) - INA gene Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges (By similarity). May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity). Taurus_UMD|evm.model.AC_000183.1.234 Q9BYE7 PCGF6_HUMAN 94.017 0.994318 1.00571 PCGF6 - Polycomb group RING finger protein 6 - Homo sapiens (Human) - PCGF6 gene Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Taurus_UMD|evm.model.AC_000183.1.235 Q15542 TAF5_HUMAN 96.114 0.952924 0.87625 TAF5 - Transcription initiation factor TFIID subunit 5 - Homo sapiens (Human) - TAF5 gene TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed. Taurus_UMD|evm.model.AC_000183.1.236 A7MB10 RRP5_BOVIN 99.787 0.998933 1.00053 PDCD11 - Protein RRP5 homolog - Bos taurus (Bovine) - PDCD11 gene Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (By similarity). Taurus_UMD|evm.model.AC_000183.1.237 Q2HJ63 CAHM2_BOVIN 100.000 0.993827 1.0031 CALHM2 - Calcium homeostasis modulator protein 2 - Bos taurus (Bovine) - CALHM2 gene Pore-forming subunit of a voltage-gated ion channel. Taurus_UMD|evm.model.AC_000183.1.238 Q8IU99 CAHM1_HUMAN 93.043 0.994203 0.99711 CALHM1 - Calcium homeostasis modulator protein 1 - Homo sapiens (Human) - CALHM1 gene Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes (By similarity). Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways (By similarity). Together with CALHM3, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs) (By similarity). Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration (PubMed:22711817, PubMed:23300080). Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions (PubMed:22711817). Acts as an activator of the ERK1 and ERK2 cascade (PubMed:23345406). Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum (PubMed:21574960). May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner (PubMed:18585350). Taurus_UMD|evm.model.AC_000183.1.239 Q86XJ0 CAHM3_HUMAN 88.372 0.872774 1.14244 CALHM3 - Calcium homeostasis modulator protein 3 - Homo sapiens (Human) - CALHM3 gene Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP. Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). CALHM1-CALHM3-mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances. Taurus_UMD|evm.model.AC_000183.1.240 O76050 NEUL1_HUMAN 95.645 0.996522 1.00174 NEURL1 - E3 ubiquitin-protein ligase NEURL1 - Homo sapiens (Human) - NEURL1 gene Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway. Taurus_UMD|evm.model.AC_000183.1.241 Q5TCZ1 SPD2A_HUMAN 90.582 0.994475 0.319506 SH3PXD2A - SH3 and PX domain-containing protein 2A - Homo sapiens (Human) - SH3PXD2A gene Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. Taurus_UMD|evm.model.AC_000183.1.242 Q5TCZ1 SPD2A_HUMAN 93.082 0.948012 0.577229 SH3PXD2A - SH3 and PX domain-containing protein 2A - Homo sapiens (Human) - SH3PXD2A gene Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. Taurus_UMD|evm.model.AC_000183.1.243 O95671 ASML_HUMAN 58.242 0.987109 0.874396 ASMTL - Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein - Homo sapiens (Human) - ASMTL gene Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). Taurus_UMD|evm.model.AC_000183.1.244 Q08DB2 STN1_BOVIN 100.000 0.882775 1.12973 STN1 - CST complex subunit STN1 - Bos taurus (Bovine) - STN1 gene Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (By similarity). Taurus_UMD|evm.model.AC_000183.1.245 Q9H2G2 SLK_HUMAN 87.842 0.998388 1.00486 SLK - STE20-like serine/threonine-protein kinase - Homo sapiens (Human) - SLK gene Mediates apoptosis and actin stress fiber dissolution. Taurus_UMD|evm.model.AC_000183.1.246 A6QPB3 COHA1_BOVIN 99.192 0.980185 1.02783 COL17A1 - Collagen alpha-1(XVII) chain - Bos taurus (Bovine) - COL17A1 gene May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. Taurus_UMD|evm.model.AC_000183.1.247 Q86XK3 SFR1_HUMAN 74.786 0.691525 1.20408 SFR1 - Swi5-dependent recombination DNA repair protein 1 homolog - Homo sapiens (Human) - SFR1 gene Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500). Taurus_UMD|evm.model.AC_000183.1.248 Q8NDM7 CFA43_HUMAN 79.808 0.998802 1.0024 CFAP43 - Cilia- and flagella-associated protein 43 - Homo sapiens (Human) - CFAP43 gene Flagellar protein involved in sperm flagellum axoneme organization and function (By similarity). Involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (By similarity). Taurus_UMD|evm.model.AC_000183.1.249 Q9N1F5 GSTO1_PIG 82.158 0.991736 1.00415 GSTO1 - Glutathione S-transferase omega-1 - Sus scrofa (Pig) - GSTO1 gene Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Taurus_UMD|evm.model.AC_000183.1.250 P78417 GSTO1_HUMAN 82.988 0.991736 1.00415 GSTO1 - Glutathione S-transferase omega-1 - Homo sapiens (Human) - GSTO1 gene Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Taurus_UMD|evm.model.AC_000183.1.251 Q9H4Y5 GSTO2_HUMAN 85.124 0.983673 1.00823 GSTO2 - Glutathione S-transferase omega-2 - Homo sapiens (Human) - GSTO2 gene Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). Taurus_UMD|evm.model.AC_000183.1.252 A7MB64 IPRI_BOVIN 100.000 0.996409 1.0018 ITPRIP - Inositol 1,4,5-trisphosphate receptor-interacting protein precursor - Bos taurus (Bovine) - ITPRIP gene Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release. Taurus_UMD|evm.model.AC_000183.1.253 Q5T655 CFA58_HUMAN 91.218 0.975973 1.00229 CFAP58 - Cilia- and flagella-associated protein 58 - Homo sapiens (Human) - CFAP58 gene cytoskeleton, extracellular space Taurus_UMD|evm.model.AC_000183.1.254 Q8WY21 SORC1_HUMAN 80.000 0.125402 0.266267 SORCS1 - VPS10 domain-containing receptor SorCS1 precursor - Homo sapiens (Human) - SORCS1 gene Golgi apparatus, integral component of membrane, membrane, neuropeptide receptor activity, neuropeptide signaling pathway, post-Golgi vesicle-mediated transport Taurus_UMD|evm.model.AC_000183.1.255 Q9UGM3 DMBT1_HUMAN 68.966 0.0468365 0.504351 DMBT1 - Deleted in malignant brain tumors 1 protein precursor - Homo sapiens (Human) - DMBT1 gene May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. Taurus_UMD|evm.model.AC_000183.1.257 O95222 OR6A2_HUMAN 63.696 0.92236 0.984709 OR6A2 - Olfactory receptor 6A2 - Homo sapiens (Human) - OR6A2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000183.1.258 P23267 OL287_RAT 71.038 0.482385 1.1865 Olr287 - Olfactory receptor 287 - Rattus norvegicus (Rat) - Olr287 gene Odorant receptor. Taurus_UMD|evm.model.AC_000183.1.259 A0RZB4 SPRN_BOVIN 100.000 0.986111 1.00699 SPRN - Shadow of prion protein precursor - Bos taurus (Bovine) - SPRN gene Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity). Taurus_UMD|evm.model.AC_000183.1.260 Q4PS77 MTG1_BOVIN 97.289 0.993921 0.990964 MTG1 - Mitochondrial ribosome-associated GTPase 1 precursor - Bos taurus (Bovine) - MTG1 gene Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity (By similarity). Displays mitochondrial GTPase activity (By similarity). Taurus_UMD|evm.model.AC_000183.1.261 Q865R1 PAOX_BOVIN 99.609 0.782542 1.27539 PAOX - Peroxisomal N(1)-acetyl-spermine/spermidine oxidase precursor - Bos taurus (Bovine) - PAOX gene Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration. Taurus_UMD|evm.model.AC_000183.1.262 Q58DM8 ECHM_BOVIN 100.000 0.993127 1.00345 ECHS1 - Enoyl-CoA hydratase, mitochondrial precursor - Bos taurus (Bovine) - ECHS1 gene Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity). Taurus_UMD|evm.model.AC_000183.1.263 Q0P563 FUCM_BOVIN 98.701 0.987097 1.01307 FUOM - Fucose mutarotase - Bos taurus (Bovine) - FUOM gene Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes. Taurus_UMD|evm.model.AC_000183.1.264 Q80XD8 PRAP1_MOUSE 51.724 0.338983 2.77181 Prap1 - Proline-rich acidic protein 1 precursor - Mus musculus (Mouse) - Prap1 gene Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (PubMed:33168624). Protects the gastrointestinal epithelium from irradiation-induced apoptosis (PubMed:32629119). May play an important role in maintaining normal growth homeostasis in epithelial cells (By similarity). Involved in p53/TP53-dependent cell survival after DNA damage (By similarity). Taurus_UMD|evm.model.AC_000183.1.265 Q9DCA7 CALY_MOUSE 72.159 0.734783 1.0177 Caly - Neuron-specific vesicular protein calcyon - Mus musculus (Mouse) - Caly gene Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis. Taurus_UMD|evm.model.AC_000183.1.268 Q2VL87 MSX1_MACMU 70.192 0.559783 0.607261 MSX1 - Homeobox protein MSX-1 - Macaca mulatta (Rhesus macaque) - MSX1 gene Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). Taurus_UMD|evm.model.AC_000183.1.269 Q8NB15 ZN511_HUMAN 76.772 0.988281 1.01587 ZNF511 - Zinc finger protein 511 - Homo sapiens (Human) - ZNF511 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000183.1.270 Q921G8 GCP2_MOUSE 90.387 0.997792 1.0011 Tubgcp2 - Gamma-tubulin complex component 2 - Mus musculus (Mouse) - Tubgcp2 gene Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Plays a role in neuronal migration. Taurus_UMD|evm.model.AC_000183.1.272 P78325 ADAM8_HUMAN 64.303 0.997619 1.01942 ADAM8 - Disintegrin and metalloproteinase domain-containing protein 8 precursor - Homo sapiens (Human) - ADAM8 gene Possible involvement in extravasation of leukocytes. Taurus_UMD|evm.model.AC_000183.1.273 Q58DA1 SPEF1_BOVIN 57.895 0.256849 1.23729 SPEF1 - Sperm flagellar protein 1 - Bos taurus (Bovine) - SPEF1 gene Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity). Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities and for ciliary localization of HYDIN and SPAG6 in ependymal cilia (By similarity). Binds actin in intestinal epithelial cells (IECs), essential for IECs survival and contributes to formation of filopodia and lamellipodia in migrating IECs (By similarity). Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (By similarity). Taurus_UMD|evm.model.AC_000183.1.274 Q5T230 UTF1_HUMAN 75.000 0.659751 0.706745 UTF1 - Undifferentiated embryonic cell transcription factor 1 - Homo sapiens (Human) - UTF1 gene Acts as a transcriptional coactivator of ATF2. Taurus_UMD|evm.model.AC_000183.1.275 P62865 UBIM_BOVIN 77.551 0.410256 1.58108 FAU - Ubiquitin-like protein FUBI - Bos taurus (Bovine) - FAU gene Taurus_UMD|evm.model.AC_000183.1.276 Q76NI1 KNDC1_HUMAN 90.052 0.964467 0.112636 KNDC1 - Kinase non-catalytic C-lobe domain-containing protein 1 - Homo sapiens (Human) - KNDC1 gene RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352). Taurus_UMD|evm.model.AC_000183.1.277 Q9UPU3 SORC3_HUMAN 97.013 0.99779 0.740589 SORCS3 - VPS10 domain-containing receptor SorCS3 precursor - Homo sapiens (Human) - SORCS3 gene integral component of membrane, integral component of postsynaptic density membrane, membrane, neuropeptide receptor activity, neuropeptide signaling pathway Taurus_UMD|evm.model.AC_000183.1.279 Q8VI51 SORC3_MOUSE 90.625 0.15736 0.161608 Sorcs3 - VPS10 domain-containing receptor SorCS3 precursor - Mus musculus (Mouse) - Sorcs3 gene glutamatergic synapse, integral component of membrane, integral component of postsynaptic density membrane, postsynaptic density, learning, memory, regulation of long-term synaptic depression Taurus_UMD|evm.model.AC_000183.1.281 Q9H444 CHM4B_HUMAN 90.411 0.873494 0.741071 CHMP4B - Charged multivesicular body protein 4b - Homo sapiens (Human) - CHMP4B gene Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Taurus_UMD|evm.model.AC_000183.1.282 Q10126 YSM6_CAEEL 26.667 0.337156 1.56272 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000183.1.283 Q3SZ63 NOP56_BOVIN 98.374 0.595122 0.34396 NOP56 - Nucleolar protein 56 - Bos taurus (Bovine) - NOP56 gene Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). Taurus_UMD|evm.model.AC_000183.1.285 Q1JPJ2 XPP1_BOVIN 100.000 0.932534 1.07063 XPNPEP1 - Xaa-Pro aminopeptidase 1 - Bos taurus (Bovine) - XPNPEP1 gene Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (By similarity). Taurus_UMD|evm.model.AC_000183.1.286 Q2TBV0 BEX2_BOVIN 84.000 0.868421 0.890625 BEX2 - Protein BEX2 - Bos taurus (Bovine) - BEX2 gene Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity). Taurus_UMD|evm.model.AC_000183.1.288 Q9UEY8 ADDG_HUMAN 96.081 0.997101 0.977337 ADD3 - Gamma-adducin - Homo sapiens (Human) - ADD3 gene Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin. Taurus_UMD|evm.model.AC_000183.1.290 O09015 MXI1_RAT 95.089 0.763699 1.2807 Mxi1 - Max-interacting protein 1 - Rattus norvegicus (Rat) - Mxi1 gene Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX. Taurus_UMD|evm.model.AC_000183.1.291 Q5R591 SPF30_PONAB 99.580 0.940476 1.05882 SMNDC1 - Survival of motor neuron-related-splicing factor 30 - Pongo abelii (Sumatran orangutan) - SMNDC1 gene Necessary for spliceosome assembly. Overexpression causes apoptosis (By similarity). Taurus_UMD|evm.model.AC_000183.1.292 Q16690 DUS5_HUMAN 93.229 0.836245 1.19271 DUSP5 - Dual specificity protein phosphatase 5 - Homo sapiens (Human) - DUSP5 gene Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1. Taurus_UMD|evm.model.AC_000183.1.293 O95196 CSPG5_HUMAN 82.162 0.87619 0.742049 CSPG5 - Chondroitin sulfate proteoglycan 5 precursor - Homo sapiens (Human) - CSPG5 gene May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. Taurus_UMD|evm.model.AC_000183.1.294 Q5R4K5 SMC3_PONAB 98.862 0.998375 1.0115 SMC3 - Structural maintenance of chromosomes protein 3 - Pongo abelii (Sumatran orangutan) - SMC3 gene Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity). Taurus_UMD|evm.model.AC_000183.1.295 Q5T481 RBM20_HUMAN 77.612 0.653061 0.0798696 RBM20 - RNA-binding protein 20 - Homo sapiens (Human) - RBM20 gene RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac development. Regulates splicing of TTN (Titin). Taurus_UMD|evm.model.AC_000183.1.296 Q8N743 KI3L3_HUMAN 41.121 0.224576 1.15122 KIR3DL3 - Killer cell immunoglobulin-like receptor 3DL3 precursor - Homo sapiens (Human) - KIR3DL3 gene Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis. Taurus_UMD|evm.model.AC_000183.1.297 Q5T481 RBM20_HUMAN 85.176 0.933985 1 RBM20 - RNA-binding protein 20 - Homo sapiens (Human) - RBM20 gene RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac development. Regulates splicing of TTN (Titin). Taurus_UMD|evm.model.AC_000183.1.299 Q9JID1 PDCD4_RAT 97.015 0.995745 1.00213 Pdcd4 - Programmed cell death protein 4 - Rattus norvegicus (Rat) - Pdcd4 gene Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). Taurus_UMD|evm.model.AC_000183.1.300 A8MTZ0 BBIP1_HUMAN 83.117 0.174825 4.66304 BBIP1 - BBSome-interacting protein 1 - Homo sapiens (Human) - BBIP1 gene The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for primary cilia assembly and BBSome stability. Regulates cytoplasmic microtubule stability and acetylation. Taurus_UMD|evm.model.AC_000183.1.301 A6QLV3 SHOC2_BOVIN 100.000 0.996569 1.00172 SHOC2 - Leucine-rich repeat protein SHOC-2 - Bos taurus (Bovine) - SHOC2 gene Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. Taurus_UMD|evm.model.AC_000183.1.302 Q28838 ADA2A_BOVIN 100.000 0.995736 1.00214 ADRA2A - Alpha-2A adrenergic receptor - Bos taurus (Bovine) - ADRA2A gene Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). Taurus_UMD|evm.model.AC_000183.1.304 Q5GJ77 GPAT1_BOVIN 98.909 0.997579 1.00121 GPAM - Glycerol-3-phosphate acyltransferase 1, mitochondrial precursor - Bos taurus (Bovine) - GPAM gene Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids. Taurus_UMD|evm.model.AC_000183.1.305 Q96PL2 TECTB_HUMAN 95.137 0.993939 1.00304 TECTB - Beta-tectorin precursor - Homo sapiens (Human) - TECTB gene One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Taurus_UMD|evm.model.AC_000183.1.306 Q6TL19 GUC2G_MOUSE 64.336 0.986111 0.130909 Gucy2g - Guanylate cyclase 2G precursor - Mus musculus (Mouse) - Gucy2g gene Probably plays a specific functional role in the testis by binding to yet not identified ligand. Taurus_UMD|evm.model.AC_000183.1.307 P55205 GUC2G_RAT 61.538 0.25448 0.507273 Gucy2g - Guanylate cyclase 2G precursor - Rattus norvegicus (Rat) - Gucy2g gene Binds to a yet not identified ligand. Taurus_UMD|evm.model.AC_000183.1.308 O88813 ACSL5_RAT 82.138 0.977077 1.02196 Acsl5 - Long-chain-fatty-acid--CoA ligase 5 - Rattus norvegicus (Rat) - Acsl5 gene Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:28209804). ACSL5 may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL at the villus tip of the crypt-villus axis of the small intestine (By similarity). May have a role in the survival of glioma cells (By similarity). May activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. It was suggested that it may also stimulate fatty acid oxidation. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids. Taurus_UMD|evm.model.AC_000183.1.309 Q2HJ95 ZDHC6_BOVIN 100.000 0.995169 1.00242 ZDHHC6 - Palmitoyltransferase ZDHHC6 - Bos taurus (Bovine) - ZDHHC6 gene Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (By similarity). Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (By similarity). Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (By similarity). Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function (By similarity). Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation (By similarity). Taurus_UMD|evm.model.AC_000183.1.310 Q96AJ9 VTI1A_HUMAN 95.349 0.984615 0.599078 VTI1A - Vesicle transport through interaction with t-SNAREs homolog 1A - Homo sapiens (Human) - VTI1A gene V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. Taurus_UMD|evm.model.AC_000183.1.312 Q924A0 TF7L2_MOUSE 98.777 0.695096 1.02179 Tcf7l2 - Transcription factor 7-like 2 - Mus musculus (Mouse) - Tcf7l2 gene Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif CCTTTGATC in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1 (By similarity). Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. Taurus_UMD|evm.model.AC_000183.1.313 Q5E9Z2 HABP2_BOVIN 100.000 0.996422 1.00179 HABP2 - Hyaluronan-binding protein 2 precursor - Bos taurus (Bovine) - HABP2 gene Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity). Taurus_UMD|evm.model.AC_000183.1.314 Q86VF7 NRAP_HUMAN 90.925 0.998845 1.00058 NRAP - Nebulin-related-anchoring protein - Homo sapiens (Human) - NRAP gene May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. Taurus_UMD|evm.model.AC_000183.1.315 P55210 CASP7_HUMAN 90.602 0.602273 1.45215 CASP7 - Caspase-7 precursor - Homo sapiens (Human) - CASP7 gene Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. Taurus_UMD|evm.model.AC_000183.1.316 Q5SXH7 PKHS1_HUMAN 66.176 0.841336 1.03011 PLEKHS1 - Pleckstrin homology domain-containing family S member 1 - Homo sapiens (Human) - PLEKHS1 gene Taurus_UMD|evm.model.AC_000183.1.317 Q6PJP8 DCR1A_HUMAN 73.219 0.998099 1.01154 DCLRE1A - DNA cross-link repair 1A protein - Homo sapiens (Human) - DCLRE1A gene May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Taurus_UMD|evm.model.AC_000183.1.318 A4IF69 NHLC2_BOVIN 100.000 0.997249 1.00138 NHLRC2 - NHL repeat-containing protein 2 - Bos taurus (Bovine) - NHLRC2 gene Required for normal embryonic development. Taurus_UMD|evm.model.AC_000183.1.319 Q9TT96 ADRB1_BOVIN 98.929 0.904854 1.10278 ADRB1 - Beta-1 adrenergic receptor - Bos taurus (Bovine) - ADRB1 gene Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). Taurus_UMD|evm.model.AC_000183.1.320 Q5R9B3 CC186_PONAB 95.100 0.738392 1.28157 CCDC186 - Coiled-coil domain-containing protein 186 - Pongo abelii (Sumatran orangutan) - CCDC186 gene Taurus_UMD|evm.model.AC_000183.1.321 Q9BXT4 TDRD1_HUMAN 79.422 0.990725 1.00508 TDRD1 - Tudor domain-containing protein 1 - Homo sapiens (Human) - TDRD1 gene Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity). Taurus_UMD|evm.model.AC_000183.1.322 Q5GFL6 VWA2_HUMAN 79.947 0.737255 1.35099 VWA2 - von Willebrand factor A domain-containing protein 2 precursor - Homo sapiens (Human) - VWA2 gene basement membrane, collagen-containing extracellular matrix, extracellular exosome, extracellular space, identical protein binding, calcium-independent cell-matrix adhesion, regulation of insulin receptor signaling pathway Taurus_UMD|evm.model.AC_000183.1.323 Q17R10 AF1L2_BOVIN 100.000 0.997555 1.00122 AFAP1L2 - Actin filament-associated protein 1-like 2 - Bos taurus (Bovine) - AFAP1L2 gene May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation (By similarity). Taurus_UMD|evm.model.AC_000183.1.324 O14639 ABLM1_HUMAN 88.136 0.989691 0.872751 ABLIM1 - Actin-binding LIM protein 1 - Homo sapiens (Human) - ABLIM1 gene May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. Taurus_UMD|evm.model.AC_000183.1.325 Q9BX40 LS14B_HUMAN 85.034 0.512545 0.724675 LSM14B - Protein LSM14 homolog B - Homo sapiens (Human) - LSM14B gene Required for oocyte meiotic maturation. May be involved in the storage of translationally inactive mRNAs and protect them from degradation (By similarity). Plays a role in control of mRNA translation (By similarity). Taurus_UMD|evm.model.AC_000183.1.327 A0JNG7 F16B1_BOVIN 97.516 0.997326 0.977778 FHIP2A - FHF complex subunit HOOK interacting protein 2A - Bos taurus (Bovine) - FHIP2A gene May be required for proper functioning of the nervous system. Taurus_UMD|evm.model.AC_000183.1.329 Q8WWH5 TRUB1_HUMAN 91.738 0.991501 1.01146 TRUB1 - Probable tRNA pseudouridine synthase 1 - Homo sapiens (Human) - TRUB1 gene Pseudouridine synthase that catalyzes pseudouridylation of mRNAs (PubMed:28073919). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Taurus_UMD|evm.model.AC_000183.1.330 Q5VV63 ATRN1_HUMAN 80.400 0.978428 0.470631 ATRNL1 - Attractin-like protein 1 precursor - Homo sapiens (Human) - ATRNL1 gene May play a role in melanocortin signaling pathways that regulate energy homeostasis. Taurus_UMD|evm.model.AC_000183.1.331 P56159 GFRA1_HUMAN 86.893 0.67509 0.595699 GFRA1 - GDNF family receptor alpha-1 precursor - Homo sapiens (Human) - GFRA1 gene Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity). Taurus_UMD|evm.model.AC_000183.1.333 Q2YDH9 CC172_BOVIN 99.615 0.992337 1.00385 CCDC172 - Coiled-coil domain-containing protein 172 - Bos taurus (Bovine) - CCDC172 gene cytoplasm, sperm midpiece Taurus_UMD|evm.model.AC_000183.1.334 Q17RR3 LIPR3_HUMAN 79.957 0.995745 1.00642 PNLIPRP3 - Pancreatic lipase-related protein 3 precursor - Homo sapiens (Human) - PNLIPRP3 gene extracellular space, lipase activity, triglyceride lipase activity, lipid catabolic process Taurus_UMD|evm.model.AC_000183.1.335 Q8IXB1 DJC10_HUMAN 91.299 0.997481 1.00126 DNAJC10 - DnaJ homolog subfamily C member 10 precursor - Homo sapiens (Human) - DNAJC10 gene Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. Taurus_UMD|evm.model.AC_000183.1.336 P16233 LIPP_HUMAN 83.778 0.984649 0.980645 PNLIP - Pancreatic triacylglycerol lipase precursor - Homo sapiens (Human) - PNLIP gene Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones. Taurus_UMD|evm.model.AC_000183.1.337 A5PK46 LIPR2_BOVIN 100.000 0.0575221 1.44563 PNLIPRP2 - Pancreatic lipase-related protein 2 precursor - Bos taurus (Bovine) - PNLIPRP2 gene Lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides. Hydrolyzes short- medium- and long-chain fatty acyls in triglycerides without apparent positional specificity. Can completely deacylates triacylglycerols. When liver matures and bile salt synthesis increases, it likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in plant-based diet releasing long-chain polyunsaturated fatty acids. Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides. Hydrolyzes long-chain monoglycerides with high efficiency (By similarity). In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Has also low phospholipase activity, but its physiological relevance is not clear (By similarity). Taurus_UMD|evm.model.AC_000183.1.338 A6QPC0 CJ082_BOVIN 100.000 0.257993 3.85957 Uncharacterized protein C10orf82 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000183.1.340 A6NNW6 ENO4_HUMAN 83.360 0.995114 0.9824 ENO4 - Enolase 4 - Homo sapiens (Human) - ENO4 gene May be required for sperm motility and function. Taurus_UMD|evm.model.AC_000183.1.341 Q5RA03 SHOT1_PONAB 91.009 0.72337 1.37939 SHTN1 - Shootin-1 - Pongo abelii (Sumatran orangutan) - SHTN1 gene Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. Taurus_UMD|evm.model.AC_000183.1.342 Q5SQQ9 VAX1_HUMAN 97.305 0.993994 0.997006 VAX1 - Ventral anterior homeobox 1 - Homo sapiens (Human) - VAX1 gene Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk (By similarity). Taurus_UMD|evm.model.AC_000183.1.344 Q7Z418 KCNKI_HUMAN 72.917 0.994751 0.992188 KCNK18 - Potassium channel subfamily K member 18 - Homo sapiens (Human) - KCNK18 gene Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity). Taurus_UMD|evm.model.AC_000183.1.345 Q27963 VMAT2_BOVIN 99.807 0.996139 1.00193 SLC18A2 - Synaptic vesicular amine transporter - Bos taurus (Bovine) - SLC18A2 gene Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. Taurus_UMD|evm.model.AC_000183.1.346 Q8NEN9 PDZD8_HUMAN 89.974 0.998268 1.00087 PDZD8 - PDZ domain-containing protein 8 - Homo sapiens (Human) - PDZD8 gene Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). Taurus_UMD|evm.model.AC_000183.1.347 Q17R00 EMX2_BOVIN 100.000 0.992126 1.00395 EMX2 - Homeobox protein EMX2 - Bos taurus (Bovine) - EMX2 gene Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system (By similarity). Taurus_UMD|evm.model.AC_000183.1.349 Q7L804 RFIP2_HUMAN 92.773 0.996094 1 RAB11FIP2 - Rab11 family-interacting protein 2 - Homo sapiens (Human) - RAB11FIP2 gene A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. Taurus_UMD|evm.model.AC_000183.1.350 Q3ZCI6 F204A_BOVIN 100.000 0.991453 1.00429 FAM204A - Protein FAM204A - Bos taurus (Bovine) - FAM204A gene Taurus_UMD|evm.model.AC_000183.1.352 Q4EW11 PRLHR_BOVIN 100.000 0.994609 1.0027 PRLHR - Prolactin-releasing peptide receptor - Bos taurus (Bovine) - PRLHR gene Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing (By similarity). Taurus_UMD|evm.model.AC_000183.1.353 Q86Y37 CACL1_HUMAN 82.031 0.991111 0.609756 CACUL1 - CDK2-associated and cullin domain-containing protein 1 - Homo sapiens (Human) - CACUL1 gene Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition. Taurus_UMD|evm.model.AC_000183.1.354 Q8WY41 NANO1_HUMAN 94.828 0.66474 0.592466 NANOS1 - Nanos homolog 1 - Homo sapiens (Human) - NANOS1 gene May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. Taurus_UMD|evm.model.AC_000183.1.355 Q14152 EIF3A_HUMAN 93.669 0.998548 0.996382 EIF3A - Eukaryotic translation initiation factor 3 subunit A - Homo sapiens (Human) - EIF3A gene RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). Taurus_UMD|evm.model.AC_000183.1.356 Q8TCE6 DEN10_HUMAN 94.958 0.994413 1.0028 DENND10 - DENN domain-containing protein 10 - Homo sapiens (Human) - DENND10 gene Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP-bound form. Taurus_UMD|evm.model.AC_000183.1.357 Q3T0M2 SFXN4_BOVIN 100.000 0.993631 1.00319 SFXN4 - Sideroflexin-4 - Bos taurus (Bovine) - SFXN4 gene Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity). Taurus_UMD|evm.model.AC_000183.1.358 P35705 PRDX3_BOVIN 100.000 0.992248 1.00389 PRDX3 - Thioredoxin-dependent peroxide reductase, mitochondrial precursor - Bos taurus (Bovine) - PRDX3 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Taurus_UMD|evm.model.AC_000183.1.359 P43249 GRK5_BOVIN 97.400 0.961603 1.01525 GRK5 - G protein-coupled receptor kinase 5 - Bos taurus (Bovine) - GRK5 gene Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors (Beta-2 adrenergic receptor), muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro) (By similarity). Taurus_UMD|evm.model.AC_000183.1.360 Q2KHW7 RGS10_BOVIN 100.000 0.989011 1.00552 RGS10 - Regulator of G-protein signaling 10 - Bos taurus (Bovine) - RGS10 gene Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein. Taurus_UMD|evm.model.AC_000183.1.361 Q01085 TIAR_HUMAN 100.000 0.761468 1.16267 TIAL1 - Nucleolysin TIAR - Homo sapiens (Human) - TIAL1 gene RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. Taurus_UMD|evm.model.AC_000183.1.362 O95817 BAG3_HUMAN 82.542 0.996587 1.01913 BAG3 - BAG family molecular chaperone regulator 3 - Homo sapiens (Human) - BAG3 gene Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). Taurus_UMD|evm.model.AC_000183.1.363 Q9Y2H2 SAC2_HUMAN 94.872 0.0733333 0.927562 INPP5F - Phosphatidylinositide phosphatase SAC2 - Homo sapiens (Human) - INPP5F gene Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). Taurus_UMD|evm.model.AC_000183.1.364 A5PJM5 MCMBP_BOVIN 97.112 0.996965 1.02648 MCMBP - Mini-chromosome maintenance complex-binding protein - Bos taurus (Bovine) - MCMBP gene Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity). Taurus_UMD|evm.model.AC_000183.1.365 Q9Y6Y8 S23IP_HUMAN 90.060 0.998014 1.007 SEC23IP - SEC23-interacting protein - Homo sapiens (Human) - SEC23IP gene Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). Taurus_UMD|evm.model.AC_000183.1.366 Q5VZY2 PLPP4_HUMAN 93.985 0.846645 1.15498 PLPP4 - Phospholipid phosphatase 4 - Homo sapiens (Human) - PLPP4 gene Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the degradation or generation of lipid-signaling molecules like diacylglycerol (PubMed:28851360). Taurus_UMD|evm.model.AC_000183.1.367 Q9BZH6 WDR11_HUMAN 96.108 0.930599 1.03595 WDR11 - WD repeat-containing protein 11 - Homo sapiens (Human) - WDR11 gene Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Taurus_UMD|evm.model.AC_000183.1.369 P21802 FGFR2_HUMAN 92.597 0.975 1.02314 FGFR2 - Fibroblast growth factor receptor 2 precursor - Homo sapiens (Human) - FGFR2 gene Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Taurus_UMD|evm.model.AC_000183.1.370 O95260 ATE1_HUMAN 87.091 0.996146 1.00193 ATE1 - Arginyl-tRNA--protein transferase 1 - Homo sapiens (Human) - ATE1 gene Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity). Taurus_UMD|evm.model.AC_000183.1.371 Q8R0E5 ZRAS1_MOUSE 40.761 0.491803 1.71831 Znrd1-as - Putative uncharacterized protein ZNRD1-AS1 - Mus musculus (Mouse) - Znrd1-as gene May be involved in male sterility. Taurus_UMD|evm.model.AC_000183.1.372 Q2TBI1 NSE4A_BOVIN 100.000 0.994778 1.00262 NSMCE4A - Non-structural maintenance of chromosomes element 4 homolog A - Bos taurus (Bovine) - NSMCE4A gene Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). Taurus_UMD|evm.model.AC_000183.1.373 O75410 TACC1_HUMAN 71.429 0.0747496 3.47329 TACC1 - Transforming acidic coiled-coil-containing protein 1 - Homo sapiens (Human) - TACC1 gene Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. Taurus_UMD|evm.model.AC_000183.1.374 Q32L18 BTBDG_BOVIN 98.419 0.935185 1.08216 BTBD16 - BTB/POZ domain-containing protein 16 - Bos taurus (Bovine) - BTBD16 gene Taurus_UMD|evm.model.AC_000183.1.376 Q8BUL6 PKHA1_MOUSE 96.000 0.738272 1.05744 Plekha1 - Pleckstrin homology domain-containing family A member 1 - Mus musculus (Mouse) - Plekha1 gene Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). Taurus_UMD|evm.model.AC_000183.1.377 F1N152 HTRA1_BOVIN 70.842 0.907328 0.952772 HTRA1 - Serine protease HTRA1 precursor - Bos taurus (Bovine) - HTRA1 gene Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets (By similarity). Taurus_UMD|evm.model.AC_000183.1.378 Q9UGM3 DMBT1_HUMAN 75.077 0.452534 0.580605 DMBT1 - Deleted in malignant brain tumors 1 protein precursor - Homo sapiens (Human) - DMBT1 gene May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. Taurus_UMD|evm.model.AC_000183.1.379 P82292 Z13_BOVIN 94.828 0.851852 1.16379 Spermadhesin Z13 - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000183.1.380 P29392 SPAD1_BOVIN 100.000 0.985185 1.00746 SPADH1 - Spermadhesin-1 precursor - Bos taurus (Bovine) - SPADH1 gene Stimulates cell division and progesterone secretion of bovine granulosa cells in vitro in a potent and dose dependent manner. This protein appears to be a potent growth factor with effects on ovarian granulosa cells. Taurus_UMD|evm.model.AC_000183.1.381 Q32KT7 CJ120_BOVIN 99.708 0.994186 1.00292 Uncharacterized protein C10orf120 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000183.1.382 Q9UGM3 DMBT1_HUMAN 66.304 0.0385757 0.977621 DMBT1 - Deleted in malignant brain tumors 1 protein precursor - Homo sapiens (Human) - DMBT1 gene May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. Taurus_UMD|evm.model.AC_000183.1.383 A6NFZ4 FA24A_HUMAN 48.485 0.705426 1.22857 FAM24A - Protein FAM24A precursor - Homo sapiens (Human) - FAM24A gene Taurus_UMD|evm.model.AC_000183.1.384 Q9H8K7 PAAT_HUMAN 74.607 0.995516 1.00225 PAAT - ATPase PAAT - Homo sapiens (Human) - PAAT gene ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848). Taurus_UMD|evm.model.AC_000183.1.385 A6NFZ4 FA24A_HUMAN 50.980 0.949495 0.942857 FAM24A - Protein FAM24A precursor - Homo sapiens (Human) - FAM24A gene Taurus_UMD|evm.model.AC_000183.1.386 Q9H8K7 PAAT_HUMAN 74.150 0.990991 0.997753 PAAT - ATPase PAAT - Homo sapiens (Human) - PAAT gene ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848). Taurus_UMD|evm.model.AC_000183.1.387 Q8IV42 PSTK_HUMAN 77.627 0.818942 1.03161 PSTK - L-seryl-tRNA(Sec) kinase - Homo sapiens (Human) - PSTK gene Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis. Taurus_UMD|evm.model.AC_000183.1.388 A4IFJ6 IKZF5_BOVIN 100.000 0.995238 1.00239 IKZF5 - Zinc finger protein Pegasus - Bos taurus (Bovine) - IKZF5 gene DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor (By similarity). Taurus_UMD|evm.model.AC_000183.1.389 Q5EAD4 ACDSB_BOVIN 100.000 0.995381 1.00231 ACADSB - Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial precursor - Bos taurus (Bovine) - ACADSB gene Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the removal of one hydrogen from C-2 and C-3 of the fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (By similarity). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway (By similarity). Can also act on valproyl-CoA, a metabolite of the valproic acid drug (By similarity). Taurus_UMD|evm.model.AC_000183.1.390 A6NHT5 HMX3_HUMAN 98.050 0.994444 1.0084 HMX3 - Homeobox protein HMX3 - Homo sapiens (Human) - HMX3 gene Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity). Taurus_UMD|evm.model.AC_000183.1.391 P43687 HMX2_MOUSE 94.891 0.992727 1.00733 Hmx2 - Homeobox protein HMX2 - Mus musculus (Mouse) - Hmx2 gene Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Taurus_UMD|evm.model.AC_000183.1.392 O43684 BUB3_HUMAN 100.000 0.993921 1.00305 BUB3 - Mitotic checkpoint protein BUB3 - Homo sapiens (Human) - BUB3 gene Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Taurus_UMD|evm.model.AC_000183.1.394 Q8NDV2 GPR26_HUMAN 99.074 0.442149 0.718101 GPR26 - G-protein coupled receptor 26 - Homo sapiens (Human) - GPR26 gene Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. Taurus_UMD|evm.model.AC_000183.1.395 Q9D2L5 CPXM2_MOUSE 95.046 0.99537 0.848168 Cpxm2 - Inactive carboxypeptidase-like protein X2 precursor - Mus musculus (Mouse) - Cpxm2 gene May be involved in cell-cell interactions. Taurus_UMD|evm.model.AC_000183.1.396 Q7LFX5 CHSTF_HUMAN 90.553 0.996441 1.00178 CHST15 - Carbohydrate sulfotransferase 15 - Homo sapiens (Human) - CHST15 gene Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo. Taurus_UMD|evm.model.AC_000183.1.399 Q3ZCF5 OAT_BOVIN 99.772 0.995455 1.00228 OAT - Ornithine aminotransferase, mitochondrial precursor - Bos taurus (Bovine) - OAT gene mitochondrial matrix, identical protein binding Taurus_UMD|evm.model.AC_000183.1.400 P15858 EMS_APIME 89.362 0.160279 3.87838 Homeobox protein H40 - Apis mellifera (Honeybee) Taurus_UMD|evm.model.AC_000183.1.401 Q0VD18 LHPP_BOVIN 100.000 0.99262 1.0037 LHPP - Phospholysine phosphohistidine inorganic pyrophosphate phosphatase - Bos taurus (Bovine) - LHPP gene Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency. Taurus_UMD|evm.model.AC_000183.1.403 Q14153 FA53B_HUMAN 77.358 0.995074 0.962085 FAM53B - Protein FAM53B - Homo sapiens (Human) - FAM53B gene Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. Taurus_UMD|evm.model.AC_000183.1.405 Q5JPI9 EFMT2_HUMAN 91.146 0.805907 0.814433 EEF1AKMT2 - EEF1A lysine methyltransferase 2 - Homo sapiens (Human) - EEF1AKMT2 gene Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. Taurus_UMD|evm.model.AC_000183.1.406 A6QLR3 ABRX2_BOVIN 99.755 0.957647 1.03912 ABRAXAS2 - BRISC complex subunit Abraxas 2 - Bos taurus (Bovine) - ABRAXAS2 gene Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (By similarity). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Required for normal induction of p53/TP53 in response to DNA damage. Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (By similarity). Taurus_UMD|evm.model.AC_000183.1.407 A6QP16 ZRAN1_BOVIN 100.000 0.960598 1.03955 ZRANB1 - Ubiquitin thioesterase ZRANB1 - Bos taurus (Bovine) - ZRANB1 gene Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling (By similarity). Taurus_UMD|evm.model.AC_000183.1.408 Q0VCQ1 CTBP2_BOVIN 100.000 0.995516 1.00225 CTBP2 - C-terminal-binding protein 2 - Bos taurus (Bovine) - CTBP2 gene Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). Isoform 2 probably acts as a scaffold for specialized synapses. Taurus_UMD|evm.model.AC_000183.1.410 P26641 EF1G_HUMAN 57.143 0.981013 0.361556 EEF1G - Elongation factor 1-gamma - Homo sapiens (Human) - EEF1G gene Probably plays a role in anchoring the complex to other cellular components. Taurus_UMD|evm.model.AC_000183.1.411 P29694 EF1G_RABIT 72.000 0.4375 0.256293 EEF1G - Elongation factor 1-gamma - Oryctolagus cuniculus (Rabbit) - EEF1G gene Probably plays a role in anchoring the complex to other cellular components. Taurus_UMD|evm.model.AC_000183.1.412 Q5VZQ5 TEX36_HUMAN 79.348 0.958115 1.02688 TEX36 - Testis-expressed protein 36 - Homo sapiens (Human) - TEX36 gene Taurus_UMD|evm.model.AC_000183.1.413 Q3B7T1 EDRF1_HUMAN 95.514 0.989499 1 EDRF1 - Erythroid differentiation-related factor 1 - Homo sapiens (Human) - EDRF1 gene Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene. Taurus_UMD|evm.model.AC_000183.1.414 P10746 HEM4_HUMAN 86.364 0.992453 1 UROS - Uroporphyrinogen-III synthase - Homo sapiens (Human) - UROS gene Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). Taurus_UMD|evm.model.AC_000183.1.415 Q2NL37 BCCIP_BOVIN 100.000 0.993485 1.00327 BCCIP - BRCA2 and CDKN1A-interacting protein - Bos taurus (Bovine) - BCCIP gene During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). Taurus_UMD|evm.model.AC_000183.1.416 Q7L7V1 DHX32_HUMAN 89.128 0.997315 1.00269 DHX32 - Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 - Homo sapiens (Human) - DHX32 gene spliceosomal complex, RNA binding Taurus_UMD|evm.model.AC_000183.1.417 Q3ZC82 ZC3HE_BOVIN 93.590 0.895349 0.117007 ZC3H14 - Zinc finger CCCH domain-containing protein 14 - Bos taurus (Bovine) - ZC3H14 gene Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides. Taurus_UMD|evm.model.AC_000183.1.418 Q3ZC82 ZC3HE_BOVIN 94.915 0.217228 0.363265 ZC3H14 - Zinc finger CCCH domain-containing protein 14 - Bos taurus (Bovine) - ZC3H14 gene Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides. Taurus_UMD|evm.model.AC_000183.1.419 Q6B858 FANK1_BOVIN 99.413 0.991254 0.994203 FANK1 - Fibronectin type 3 and ankyrin repeat domains protein 1 - Bos taurus (Bovine) - FANK1 gene Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis. Taurus_UMD|evm.model.AC_000183.1.420 Q10126 YSM6_CAEEL 28.395 0.734694 0.702509 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000183.1.421 O43184 ADA12_HUMAN 79.846 0.836645 0.9967 ADAM12 - Disintegrin and metalloproteinase domain-containing protein 12 precursor - Homo sapiens (Human) - ADAM12 gene Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity). Taurus_UMD|evm.model.AC_000183.1.422 Q96M02 CJ090_HUMAN 82.199 0.272206 0.998569 C10orf90 - (E2-independent) E3 ubiquitin-conjugating enzyme FATS - Homo sapiens (Human) - C10orf90 gene Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (By similarity). May have a role in the assembly of primary cilia (Probable). Taurus_UMD|evm.model.AC_000183.1.423 Q14185 DOCK1_HUMAN 96.395 0.998908 0.982306 DOCK1 - Dedicator of cytokinesis protein 1 - Homo sapiens (Human) - DOCK1 gene Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). Taurus_UMD|evm.model.AC_000183.1.424 Q6ZQN5 FOXI2_HUMAN 77.044 0.99361 0.984277 FOXI2 - Forkhead box protein I2 - Homo sapiens (Human) - FOXI2 gene Possible transcriptional activator. Taurus_UMD|evm.model.AC_000183.1.425 Q8NCR9 CLRN3_HUMAN 73.799 0.991304 1.0177 CLRN3 - Clarin-3 - Homo sapiens (Human) - CLRN3 gene extracellular exosome Taurus_UMD|evm.model.AC_000183.1.427 P23469 PTPRE_HUMAN 92.493 0.983264 1.02429 PTPRE - Receptor-type tyrosine-protein phosphatase epsilon precursor - Homo sapiens (Human) - PTPRE gene Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Taurus_UMD|evm.model.AC_000183.1.428 P46013 KI67_HUMAN 46.389 0.869151 1.03041 MKI67 - Proliferation marker protein Ki-67 - Homo sapiens (Human) - MKI67 gene Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). Taurus_UMD|evm.model.AC_000183.1.433 Q5ZKH0 TF2H5_CHICK 75.000 0.314516 1.74648 GTF2H5 - General transcription factor IIH subunit 5 - Gallus gallus (Chicken) - GTF2H5 gene Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Taurus_UMD|evm.model.AC_000183.1.442 Q6TDU1 MGMT_CANLF 73.460 0.990566 0.981481 MGMT - Methylated-DNA--protein-cysteine methyltransferase - Canis lupus familiaris (Dog) - MGMT gene Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Taurus_UMD|evm.model.AC_000183.1.445 O08791 COE3_MOUSE 90.323 0.718447 0.864094 Ebf3 - Transcription factor COE3 - Mus musculus (Mouse) - Ebf3 gene Transcriptional activator (PubMed:9151732). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). Taurus_UMD|evm.model.AC_000183.1.446 Q63398 COE1_RAT 90.741 0.207031 0.438356 Ebf1 - Transcription factor COE1 - Rattus norvegicus (Rat) - Ebf1 gene Key pioneer transcription factor of B-cell specification and commitment. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold. Taurus_UMD|evm.model.AC_000183.1.447 Q9H4W6 COE3_HUMAN 100.000 0.416949 0.494966 EBF3 - Transcription factor COE3 - Homo sapiens (Human) - EBF3 gene Transcriptional activator (PubMed:28017373, PubMed:28017372, PubMed:28017370). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). Taurus_UMD|evm.model.AC_000183.1.449 A0A1B0GUT2 CJ143_HUMAN 59.091 0.973214 1.03704 C10orf143 - Uncharacterized protein C10orf143 - Homo sapiens (Human) - C10orf143 gene Taurus_UMD|evm.model.AC_000183.1.450 Q58DA7 GLRX3_BOVIN 99.401 0.99403 1.00299 GLRX3 - Glutaredoxin-3 - Bos taurus (Bovine) - GLRX3 gene Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). Taurus_UMD|evm.model.AC_000183.1.461 Q5VWI1 TCRGL_HUMAN 87.075 0.743455 0.325939 TCERG1L - Transcription elongation regulator 1-like protein - Homo sapiens (Human) - TCERG1L gene nucleus, RNA polymerase binding, transcription coregulator activity Taurus_UMD|evm.model.AC_000183.1.464 Q32LK9 SYCE1_BOVIN 100.000 0.993827 1.0031 SYCE1 - Synaptonemal complex central element protein 1 - Bos taurus (Bovine) - SYCE1 gene Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination. Taurus_UMD|evm.model.AC_000183.1.465 O18963 CP2E1_BOVIN 99.798 0.995968 1.00202 CYP2E1 - Cytochrome P450 2E1 - Bos taurus (Bovine) - CYP2E1 gene A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. Taurus_UMD|evm.model.AC_000183.1.466 Q5VWI1 TCRGL_HUMAN 66.516 0.101338 3.56997 TCERG1L - Transcription elongation regulator 1-like protein - Homo sapiens (Human) - TCERG1L gene nucleus, RNA polymerase binding, transcription coregulator activity Taurus_UMD|evm.model.AC_000183.1.467 Q8C4G9 AGRA1_MOUSE 75.606 0.994413 0.929066 Adgra1 - Adhesion G protein-coupled receptor A1 - Mus musculus (Mouse) - Adgra1 gene glutamatergic synapse, plasma membrane, postsynaptic density, cell surface receptor signaling pathway Taurus_UMD|evm.model.AC_000183.1.472 Q8IYW2 CFA46_HUMAN 68.361 0.954934 0.948066 CFAP46 - Cilia- and flagella-associated protein 46 - Homo sapiens (Human) - CFAP46 gene As part of the central apparatus of the cilium axoneme plays a role in cilium movement. Taurus_UMD|evm.model.AC_000183.1.473 Q9C056 NKX62_HUMAN 94.340 0.619048 0.303249 NKX6-2 - Homeobox protein Nkx-6.2 - Homo sapiens (Human) - NKX6-2 gene Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'-(A/T)TTAATGA-3'. In oligodendrocytes, binds to MBP and PLP1 promoter regions. Taurus_UMD|evm.model.AC_000183.1.474 Q14642 I5P1_HUMAN 91.688 0.902778 1.04854 INPP5A - Inositol polyphosphate-5-phosphatase A precursor - Homo sapiens (Human) - INPP5A gene Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8013665, PubMed:8769125, PubMed:8626616). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity). Taurus_UMD|evm.model.AC_000183.1.477 Q5R4A2 2ABB_PONAB 58.209 0.52 0.282167 PPP2R2B - Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform - Pongo abelii (Sumatran orangutan) - PPP2R2B gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Taurus_UMD|evm.model.AC_000183.1.478 Q32KN2 BNIP3_BOVIN 99.448 0.44226 2.07653 BNIP3 - BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 - Bos taurus (Bovine) - BNIP3 gene Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway (By similarity). Taurus_UMD|evm.model.AC_000183.1.479 Q5VZ66 JKIP3_HUMAN 93.925 0.650831 1.49645 JAKMIP3 - Janus kinase and microtubule-interacting protein 3 - Homo sapiens (Human) - JAKMIP3 gene Taurus_UMD|evm.model.AC_000183.1.480 Q62951 DPYL4_RAT 91.844 0.982548 1.01596 Dpysl4 - Dihydropyrimidinase-related protein 4 - Rattus norvegicus (Rat) - Dpysl4 gene Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). Taurus_UMD|evm.model.AC_000183.1.481 Q86UX6 ST32C_HUMAN 90.952 0.995181 0.853909 STK32C - Serine/threonine-protein kinase 32C - Homo sapiens (Human) - STK32C gene protein serine/threonine kinase activity, intracellular signal transduction, peptidyl-serine phosphorylation Taurus_UMD|evm.model.AC_000183.1.482 Q9C0I9 LRC27_HUMAN 56.679 0.996047 0.954717 LRRC27 - Leucine-rich repeat-containing protein 27 - Homo sapiens (Human) - LRRC27 gene Taurus_UMD|evm.model.AC_000183.1.483 Q6NUJ5 PWP2B_HUMAN 72.559 0.996441 0.952542 PWWP2B - PWWP domain-containing protein 2B - Homo sapiens (Human) - PWWP2B gene nucleoplasm Taurus_UMD|evm.model.AC_000183.1.484 Q9UGM3 DMBT1_HUMAN 88.073 0.650602 0.068794 DMBT1 - Deleted in malignant brain tumors 1 protein precursor - Homo sapiens (Human) - DMBT1 gene May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. Taurus_UMD|evm.model.AC_000184.1.1 Q8BJ42 DLGP2_MOUSE 87.500 0.341727 0.262512 Dlgap2 - Disks large-associated protein 2 - Mus musculus (Mouse) - Dlgap2 gene May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Taurus_UMD|evm.model.AC_000184.1.4 Q6AYM9 CLN8_RAT 80.357 0.166667 3.47917 Cln8 - Protein CLN8 - Rattus norvegicus (Rat) - Cln8 gene Could play a role in cell proliferation during neuronal differentiation and in protection against cell death. Taurus_UMD|evm.model.AC_000184.1.5 O15013 ARHGA_HUMAN 77.681 0.998537 0.998539 ARHGEF10 - Rho guanine nucleotide exchange factor 10 - Homo sapiens (Human) - ARHGEF10 gene May play a role in developmental myelination of peripheral nerves. Taurus_UMD|evm.model.AC_000184.1.6 Q8BNW9 KBTBB_MOUSE 78.582 0.996885 1.01422 Kbtbd11 - Kelch repeat and BTB domain-containing protein 11 - Mus musculus (Mouse) - Kbtbd11 gene Taurus_UMD|evm.model.AC_000184.1.7 P54296 MYOM2_HUMAN 86.107 0.995321 1.02116 MYOM2 - Myomesin-2 - Homo sapiens (Human) - MYOM2 gene Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. Taurus_UMD|evm.model.AC_000184.1.8 P08548 LIN1_NYCCO 60.681 0.576029 0.443651 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Taurus_UMD|evm.model.AC_000184.1.11 Q96PZ7 CSMD1_HUMAN 97.802 0.0947735 0.805275 CSMD1 - CUB and sushi domain-containing protein 1 precursor - Homo sapiens (Human) - CSMD1 gene Potential suppressor of squamous cell carcinomas. Taurus_UMD|evm.model.AC_000184.1.12 Q923L3 CSMD1_MOUSE 97.222 0.522059 0.0381594 Csmd1 - CUB and sushi domain-containing protein 1 precursor - Mus musculus (Mouse) - Csmd1 gene conditioned place preference, female gonad development, glucose homeostasis, male gonad development, mammary gland branching involved in pregnancy, memory, oviduct epithelium development, startle response Taurus_UMD|evm.model.AC_000184.1.15 Q96PZ7 CSMD1_HUMAN 78.495 0.942105 0.0533109 CSMD1 - CUB and sushi domain-containing protein 1 precursor - Homo sapiens (Human) - CSMD1 gene Potential suppressor of squamous cell carcinomas. Taurus_UMD|evm.model.AC_000184.1.17 Q923L3 CSMD1_MOUSE 98.630 0.66055 0.0305836 Csmd1 - CUB and sushi domain-containing protein 1 precursor - Mus musculus (Mouse) - Csmd1 gene conditioned place preference, female gonad development, glucose homeostasis, male gonad development, mammary gland branching involved in pregnancy, memory, oviduct epithelium development, startle response Taurus_UMD|evm.model.AC_000184.1.18 P49449 CENPA_BOVIN 96.377 0.985507 1 CENPA - Histone H3-like centromeric protein A - Bos taurus (Bovine) - CENPA gene Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis. Taurus_UMD|evm.model.AC_000184.1.21 B2RYG6 OTUB1_RAT 75.325 0.653846 0.863469 Otub1 - Ubiquitin thioesterase OTUB1 - Rattus norvegicus (Rat) - Otub1 gene Hydrolase that can specifically remove compared to 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin (By similarity). Taurus_UMD|evm.model.AC_000184.1.23 P61593 MCPH1_PANTR 58.901 0.989273 1.00479 MCPH1 - Microcephalin - Pan troglodytes (Chimpanzee) - MCPH1 gene Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity). Taurus_UMD|evm.model.AC_000184.1.24 Q9NUQ2 PLCE_HUMAN 84.658 0.994536 1.00549 AGPAT5 - 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon - Homo sapiens (Human) - AGPAT5 gene Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (PubMed:21173190). Activity toward lysophosphatidylglycerol not detectable (PubMed:21173190). Taurus_UMD|evm.model.AC_000184.1.25 Q6UX68 XKR5_HUMAN 62.312 0.965309 0.966472 XKR5 - XK-related protein 5 - Homo sapiens (Human) - XKR5 gene membrane, plasma membrane, apoptotic process involved in development, engulfment of apoptotic cell, phosphatidylserine exposure on apoptotic cell surface Taurus_UMD|evm.model.AC_000184.1.26 Q8TF47 ZFP90_HUMAN 62.500 0.504 0.196541 ZFP90 - Zinc finger protein 90 homolog - Homo sapiens (Human) - ZFP90 gene Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes. Taurus_UMD|evm.model.AC_000184.1.27 A6NJQ4 F90A8_HUMAN 55.682 0.275081 0.665948 FAM90A8P - Putative protein FAM90A8P - Homo sapiens (Human) - FAM90A8P gene Taurus_UMD|evm.model.AC_000184.1.28 Q95M67 DEFB1_CERER 59.701 0.942857 1.02941 DEFB1 - Beta-defensin 1 precursor - Cercopithecus erythrogaster (Red-bellied monkey) - DEFB1 gene Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. Taurus_UMD|evm.model.AC_000184.1.29 Q0W9P9 D103A_HORSE 82.090 0.970588 1.01493 DEFB103A - Beta-defensin 103A precursor - Equus caballus (Horse) - DEFB103A gene Exhibits antimicrobial activity against Gram-positive and Gram-negative bacteria. Taurus_UMD|evm.model.AC_000184.1.30 Q6ZN79 Z705A_HUMAN 58.868 0.916376 0.956667 ZNF705A - Zinc finger protein 705A - Homo sapiens (Human) - ZNF705A gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000184.1.31 P0C7X0 F90AO_HUMAN 36.196 0.463855 0.715517 FAM90A24P - Putative protein FAM90A24P - Homo sapiens (Human) - FAM90A24P gene Taurus_UMD|evm.model.AC_000184.1.32 Q08050 FOXM1_HUMAN 76.056 0.75 0.246396 FOXM1 - Forkhead box protein M1 - Homo sapiens (Human) - FOXM1 gene Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. Taurus_UMD|evm.model.AC_000184.1.34 A3RJ36 LAP_BUBBU 85.714 0.366071 1.75 Lingual antimicrobial peptide precursor - Bubalus bubalis (Domestic water buffalo) Taurus_UMD|evm.model.AC_000184.1.36 P0C7W8 F90AD_HUMAN 43.137 0.397878 0.8125 FAM90A13P - Putative protein FAM90A13P - Homo sapiens (Human) - FAM90A13P gene Taurus_UMD|evm.model.AC_000184.1.38 Q95M67 DEFB1_CERER 56.716 0.942857 1.02941 DEFB1 - Beta-defensin 1 precursor - Cercopithecus erythrogaster (Red-bellied monkey) - DEFB1 gene Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. Taurus_UMD|evm.model.AC_000184.1.41 A3RJ36 LAP_BUBBU 84.127 0.278027 3.48438 Lingual antimicrobial peptide precursor - Bubalus bubalis (Domestic water buffalo) Taurus_UMD|evm.model.AC_000184.1.42 Q0W9P9 D103A_HORSE 76.119 0.702128 1.40299 DEFB103A - Beta-defensin 103A precursor - Equus caballus (Horse) - DEFB103A gene Exhibits antimicrobial activity against Gram-positive and Gram-negative bacteria. Taurus_UMD|evm.model.AC_000184.1.43 A6NJQ4 F90A8_HUMAN 35.329 0.665072 0.450431 FAM90A8P - Putative protein FAM90A8P - Homo sapiens (Human) - FAM90A8P gene Taurus_UMD|evm.model.AC_000184.1.44 A6NNH2 F90AR_HUMAN 46.032 0.350575 0.75817 FAM90A27P - Protein FAM90A27P - Homo sapiens (Human) - FAM90A27P gene Taurus_UMD|evm.model.AC_000184.1.45 O00370 LORF2_HUMAN 66.494 0.777096 0.383529 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000184.1.46 Q32ZG1 DFB33_RAT 68.293 0.645161 1 Defb33 - Beta-defensin 33 precursor - Rattus norvegicus (Rat) - Defb33 gene Has antibacterial activity. Taurus_UMD|evm.model.AC_000184.1.48 A6NNH2 F90AR_HUMAN 48.387 0.33711 0.769063 FAM90A27P - Protein FAM90A27P - Homo sapiens (Human) - FAM90A27P gene Taurus_UMD|evm.model.AC_000184.1.49 Q95M67 DEFB1_CERER 56.716 0.942857 1.02941 DEFB1 - Beta-defensin 1 precursor - Cercopithecus erythrogaster (Red-bellied monkey) - DEFB1 gene Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. Taurus_UMD|evm.model.AC_000184.1.50 A8MXZ1 F90AN_HUMAN 75.000 0.081571 0.713362 FAM90A23P - Putative protein FAM90A23P - Homo sapiens (Human) - FAM90A23P gene Taurus_UMD|evm.model.AC_000184.1.51 A8MXZ1 F90AN_HUMAN 36.413 0.490566 0.799569 FAM90A23P - Putative protein FAM90A23P - Homo sapiens (Human) - FAM90A23P gene Taurus_UMD|evm.model.AC_000184.1.52 Q5R9Q3 GPM6A_PONAB 82.642 0.939759 0.895683 GPM6A - Neuronal membrane glycoprotein M6-a - Pongo abelii (Sumatran orangutan) - GPM6A gene Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor (By similarity). Taurus_UMD|evm.model.AC_000184.1.53 Q95M67 DEFB1_CERER 58.209 0.942857 1.02941 DEFB1 - Beta-defensin 1 precursor - Cercopithecus erythrogaster (Red-bellied monkey) - DEFB1 gene Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. Taurus_UMD|evm.model.AC_000184.1.54 A6NJQ4 F90A8_HUMAN 55.000 0.259136 0.648707 FAM90A8P - Putative protein FAM90A8P - Homo sapiens (Human) - FAM90A8P gene Taurus_UMD|evm.model.AC_000184.1.55 Q8IZU2 WDR17_HUMAN 90.300 0.987683 0.982602 WDR17 - WD repeat-containing protein 17 - Homo sapiens (Human) - WDR17 gene Taurus_UMD|evm.model.AC_000184.1.56 Q8K3V1 SPAT4_MOUSE 69.178 0.82153 1.19661 Spata4 - Spermatogenesis-associated protein 4 - Mus musculus (Mouse) - Spata4 gene May play a role in apoptosis regulation. Taurus_UMD|evm.model.AC_000184.1.57 Q17QS6 ASB5_BOVIN 100.000 0.993939 1.00304 ASB5 - Ankyrin repeat and SOCS box protein 5 - Bos taurus (Bovine) - ASB5 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the initiation of arteriogenesis (By similarity). Taurus_UMD|evm.model.AC_000184.1.58 Q6ZWQ7 SPCS3_MOUSE 83.942 0.98374 0.683333 Spcs3 - Signal peptidase complex subunit 3 - Mus musculus (Mouse) - Spcs3 gene Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Taurus_UMD|evm.model.AC_000184.1.59 P49767 VEGFC_HUMAN 87.857 0.995249 1.00477 VEGFC - Vascular endothelial growth factor C precursor - Homo sapiens (Human) - VEGFC gene Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. Taurus_UMD|evm.model.AC_000184.1.61 Q3MHN7 NEIL3_BOVIN 99.094 0.97695 0.930693 NEIL3 - Endonuclease 8-like 3 - Bos taurus (Bovine) - NEIL3 gene DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (By similarity). Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues (By similarity). Taurus_UMD|evm.model.AC_000184.1.62 P20933 ASPG_HUMAN 82.622 0.942363 1.00289 AGA - N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase precursor - Homo sapiens (Human) - AGA gene Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. Taurus_UMD|evm.model.AC_000184.1.64 P24049 RL17_RAT 67.105 0.991453 0.63587 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000184.1.66 P32321 DCTD_HUMAN 71.910 0.985714 0.786517 DCTD - Deoxycytidylate deaminase - Homo sapiens (Human) - DCTD gene Supplies the nucleotide substrate for thymidylate synthetase. Taurus_UMD|evm.model.AC_000184.1.67 Q6AWC2 WWC2_HUMAN 85.727 0.977119 0.989933 WWC2 - Protein WWC2 - Homo sapiens (Human) - WWC2 gene cytosol, kinase binding, molecular adaptor activity, negative regulation of hippo signaling, negative regulation of organ growth, negative regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000184.1.68 Q8N7P3 CLD22_HUMAN 81.356 0.98324 0.813636 CLDN22 - Claudin-22 - Homo sapiens (Human) - CLDN22 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Taurus_UMD|evm.model.AC_000184.1.69 A6NM45 CLD24_HUMAN 83.673 0.915493 0.968182 CLDN24 - Putative claudin-24 - Homo sapiens (Human) - CLDN24 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Taurus_UMD|evm.model.AC_000184.1.70 Q3SZL8 CNDH2_BOVIN 57.210 0.991781 0.586817 NCAPH2 - Condensin-2 complex subunit H2 - Bos taurus (Bovine) - NCAPH2 gene Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (By similarity). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (By similarity). Taurus_UMD|evm.model.AC_000184.1.71 Q9NXV6 CARF_HUMAN 89.212 0.996558 1.00172 CDKN2AIP - CDKN2A-interacting protein - Homo sapiens (Human) - CDKN2AIP gene Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. Taurus_UMD|evm.model.AC_000184.1.72 Q9ESK4 ING2_MOUSE 97.173 0.992958 1.01068 Ing2 - Inhibitor of growth protein 2 - Mus musculus (Mouse) - Ing2 gene Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity). Taurus_UMD|evm.model.AC_000184.1.73 Q6NW29 RWDD4_HUMAN 95.213 0.989418 1.00532 RWDD4 - RWD domain-containing protein 4 - Homo sapiens (Human) - RWDD4 gene Taurus_UMD|evm.model.AC_000184.1.74 A6QLC7 TPC11_BOVIN 99.735 0.998236 1.00088 TRAPPC11 - Trafficking protein particle complex subunit 11 - Bos taurus (Bovine) - TRAPPC11 gene Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Taurus_UMD|evm.model.AC_000184.1.75 B2RQL2 STOX1_MOUSE 38.136 0.8125 0.145455 Stox1 - Storkhead-box protein 1 - Mus musculus (Mouse) - Stox1 gene Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (By similarity). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (PubMed:25677106). Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (By similarity). Induces phosphorylation of MAPT/tau (By similarity). Taurus_UMD|evm.model.AC_000184.1.77 Q9P2F5 STOX2_HUMAN 94.062 0.997628 0.910367 STOX2 - Storkhead-box protein 2 - Homo sapiens (Human) - STOX2 gene embryo development ending in birth or egg hatching, maternal placenta development Taurus_UMD|evm.model.AC_000184.1.78 F1N5C8 ENPP6_BOVIN 100.000 0.995516 1.00225 ENPP6 - Glycerophosphocholine choline phosphodiesterase ENPP6 precursor - Bos taurus (Bovine) - ENPP6 gene Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed:23161088). Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids (By similarity). Taurus_UMD|evm.model.AC_000184.1.79 P23906 IRF2_MOUSE 92.241 0.991429 1.00287 Irf2 - Interferon regulatory factor 2 - Mus musculus (Mouse) - Irf2 gene Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. Taurus_UMD|evm.model.AC_000184.1.80 Q08DY9 CASP3_BOVIN 99.273 0.985612 1.01091 CASP3 - Caspase-3 precursor - Bos taurus (Bovine) - CASP3 gene Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Taurus_UMD|evm.model.AC_000184.1.81 Q08DZ8 PRIPO_BOVIN 100.000 0.996403 1.0018 PRIMPOL - DNA-directed primase/polymerase protein - Bos taurus (Bovine) - PRIMPOL gene DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them. Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesions, such as ultraviolet (UV) lesions, R-loops and G-quadruplexes, to allow DNA replication to continue. Can also realign primers ahead of 'unreadable lesions' such as abasic sites and 6-4 photoproduct (6-4 pyrimidine-pyrimidinone), thereby skipping the lesion. Also able to incorporate nucleotides opposite DNA lesions such as 8oxoG, like a regular translesion synthesis DNA polymerase. Also required for reinitiating stalled forks after UV damage during nuclear DNA replication. Required for mitochondrial DNA (mtDNA) synthesis and replication, by reinitiating synthesis after UV damage or in the presence of chain-terminating nucleotides (By similarity). Prevents APOBEC family-mediated DNA mutagenesis by repriming downstream of abasic site to prohibit error-prone translesion synthesis (By similarity). Has non-overlapping function with POLH. In addition to its role in DNA damage response, also required to maintain efficient nuclear and mitochondrial DNA replication in unperturbed cells (By similarity). Taurus_UMD|evm.model.AC_000184.1.82 Q2KIW5 CENPU_BOVIN 99.461 0.93199 0.973039 CENPU - Centromere protein U - Bos taurus (Bovine) - CENPU gene Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity). Taurus_UMD|evm.model.AC_000184.1.83 P33121 ACSL1_HUMAN 90.258 0.956104 1.04441 ACSL1 - Long-chain-fatty-acid--CoA ligase 1 - Homo sapiens (Human) - ACSL1 gene Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially uses palmitoleate, oleate and linoleate (PubMed:24269233). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity). Taurus_UMD|evm.model.AC_000184.1.85 A6NFD8 HELT_HUMAN 93.388 0.99177 1.00413 HELT - Hairy and enhancer of split-related protein HELT - Homo sapiens (Human) - HELT gene Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. Taurus_UMD|evm.model.AC_000184.1.86 Q8VEA4 MIA40_MOUSE 46.250 0.428571 0.956835 Chchd4 - Mitochondrial intermembrane space import and assembly protein 40 - Mus musculus (Mouse) - Chchd4 gene Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (PubMed:26004228). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake. Taurus_UMD|evm.model.AC_000184.1.87 P02722 ADT1_BOVIN 100.000 0.993311 1.00336 SLC25A4 - ADP/ATP translocase 1 - Bos taurus (Bovine) - SLC25A4 gene ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (PubMed:7961643). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (PubMed:7961643). Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (By similarity). It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). Taurus_UMD|evm.model.AC_000184.1.88 Q2KJH5 CFA97_BOVIN 99.810 0.996212 1.0019 CFAP97 - Cilia- and flagella-associated protein 97 - Bos taurus (Bovine) - CFAP97 gene Taurus_UMD|evm.model.AC_000184.1.89 Q9H3E2 SNX25_HUMAN 92.157 0.911695 0.997619 SNX25 - Sorting nexin-25 - Homo sapiens (Human) - SNX25 gene May be involved in several stages of intracellular trafficking. Taurus_UMD|evm.model.AC_000184.1.90 Q4R3N2 LR2BP_MACFA 91.954 0.994269 1.00287 LRP2BP - LRP2-binding protein - Macaca fascicularis (Crab-eating macaque) - LRP2BP gene May act as an adapter that regulates LRP2 function. Taurus_UMD|evm.model.AC_000184.1.91 Q9NUQ7 UFSP2_HUMAN 93.817 0.995745 1.00213 UFSP2 - Ufm1-specific protease 2 - Homo sapiens (Human) - UFSP2 gene Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins (PubMed:25219498, PubMed:32160526). Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (PubMed:25219498). Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (PubMed:25219498). Taurus_UMD|evm.model.AC_000184.1.92 Q2T9M0 CD047_BOVIN 99.676 0.993548 1.00324 UPF0602 protein C4orf47 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000184.1.93 Q95JS9 CC110_MACFA 77.910 0.979953 1.01801 CCDC110 - Coiled-coil domain-containing protein 110 - Macaca fascicularis (Crab-eating macaque) - CCDC110 gene Taurus_UMD|evm.model.AC_000184.1.95 Q6QGC0 PDLI3_PIG 96.438 0.994521 1 PDLIM3 - PDZ and LIM domain protein 3 - Sus scrofa (Pig) - PDLIM3 gene May play a role in the organization of actin filament arrays within muscle cells. Taurus_UMD|evm.model.AC_000184.1.96 Q3UTJ2 SRBS2_MOUSE 92.727 0.303142 0.458475 Sorbs2 - Sorbin and SH3 domain-containing protein 2 - Mus musculus (Mouse) - Sorbs2 gene Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (By similarity). Taurus_UMD|evm.model.AC_000184.1.97 P28220 SRBS2_PIG 95.683 0.252747 3.4557 SORBS2 - Sorbin and SH3 domain-containing protein 2 - Sus scrofa (Pig) - SORBS2 gene Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Increases water and sodium absorption in the intestine and gall-bladder. Taurus_UMD|evm.model.AC_000184.1.98 Q5TJ59 TLR3_BOVIN 99.336 0.99779 1.00111 TLR3 - Toll-like receptor 3 precursor - Bos taurus (Bovine) - TLR3 gene Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity). Taurus_UMD|evm.model.AC_000184.1.99 A5PLN7 F149A_HUMAN 62.301 0.997433 1.00776 FAM149A - Protein FAM149A - Homo sapiens (Human) - FAM149A gene Taurus_UMD|evm.model.AC_000184.1.100 Q5RCN6 CP4V2_PONAB 78.137 0.994318 1.00571 CYP4V2 - Cytochrome P450 4V2 - Pongo abelii (Sumatran orangutan) - CYP4V2 gene A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs. Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Taurus_UMD|evm.model.AC_000184.1.101 Q2KJ63 KLKB1_BOVIN 100.000 0.967988 1.03145 KLKB1 - Plasma kallikrein precursor - Bos taurus (Bovine) - KLKB1 gene The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin (By similarity). Taurus_UMD|evm.model.AC_000184.1.102 Q5NTB3 FA11_BOVIN 99.840 0.996805 1.0016 F11 - Coagulation factor XI precursor - Bos taurus (Bovine) - F11 gene Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Taurus_UMD|evm.model.AC_000184.1.103 O02769 MTR1A_BOVIN 98.054 0.697548 1.42802 MTNR1A - Melatonin receptor type 1A - Bos taurus (Bovine) - MTNR1A gene High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Taurus_UMD|evm.model.AC_000184.1.104 Q14517 FAT1_HUMAN 89.934 0.998689 0.997167 FAT1 - Protocadherin Fat 1 precursor - Homo sapiens (Human) - FAT1 gene Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. Taurus_UMD|evm.model.AC_000184.1.105 P62859 RS28_RAT 86.957 0.967742 0.898551 Rps28 - 40S ribosomal protein S28 - Rattus norvegicus (Rat) - Rps28 gene cytoplasmic side of rough endoplasmic reticulum membrane, cytosolic small ribosomal subunit, polysomal ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, maturation of SSU-rRNA, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosome biogenesis Taurus_UMD|evm.model.AC_000184.1.106 Q10126 YSM6_CAEEL 30.303 0.583893 0.53405 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000184.1.107 Q8ST83 PHO_DROME 68.595 0.4 0.576923 pho - Polycomb protein PHO - Drosophila melanogaster (Fruit fly) - pho gene Polycomb group (PcG) protein that binds to the 5'-CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression. Taurus_UMD|evm.model.AC_000184.1.108 Q8N7C3 TRIMM_HUMAN 61.440 0.867882 1.13437 TRIML2 - Probable E3 ubiquitin-protein ligase TRIML2 - Homo sapiens (Human) - TRIML2 gene cytoplasm, cytosol, nucleoplasm, identical protein binding, protein homodimerization activity, protein kinase binding, ubiquitin protein ligase activity, innate immune response, positive regulation of autophagy, positive regulation of I-kappaB kinase/NF-kappaB signaling Taurus_UMD|evm.model.AC_000184.1.109 Q8N9V2 TRIML_HUMAN 84.188 0.983158 1.01496 TRIML1 - Probable E3 ubiquitin-protein ligase TRIML1 - Homo sapiens (Human) - TRIML1 gene Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development. Taurus_UMD|evm.model.AC_000184.1.110 Q9H5H4 ZN768_HUMAN 82.264 0.995893 0.901852 ZNF768 - Zinc finger protein 768 - Homo sapiens (Human) - ZNF768 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000184.1.111 Q7Z7J5 DPPA2_HUMAN 58.885 0.89557 1.0604 DPPA2 - Developmental pluripotency-associated protein 2 - Homo sapiens (Human) - DPPA2 gene Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes. Taurus_UMD|evm.model.AC_000184.1.112 P83917 CBX1_MOUSE 99.419 0.988439 0.935135 Cbx1 - Chromobox protein homolog 1 - Mus musculus (Mouse) - Cbx1 gene Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Taurus_UMD|evm.model.AC_000184.1.113 Q14331 FRG1_HUMAN 98.837 0.992278 1.00388 FRG1 - Protein FRG1 - Homo sapiens (Human) - FRG1 gene Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B. Taurus_UMD|evm.model.AC_000184.1.114 Q17QB3 ASAH1_BOVIN 100.000 0.994949 1.00253 ASAH1 - Acid ceramidase precursor - Bos taurus (Bovine) - ASAH1 gene Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (By similarity). For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (By similarity). Has also an N-acylethanolamine hydrolase activity (By similarity). By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (By similarity). Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (By similarity). Taurus_UMD|evm.model.AC_000184.1.115 Q15154 PCM1_HUMAN 85.344 0.959128 1.08794 PCM1 - Pericentriolar material 1 protein - Homo sapiens (Human) - PCM1 gene Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Involved in the biogenesis of cilia (PubMed:20551181, PubMed:24121310). Taurus_UMD|evm.model.AC_000184.1.116 Q3SZZ7 FGL1_BOVIN 100.000 0.984177 1.01282 FGL1 - Fibrinogen-like protein 1 precursor - Bos taurus (Bovine) - FGL1 gene Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes. Taurus_UMD|evm.model.AC_000184.1.118 Q17QT2 MTUS1_BOVIN 95.604 0.34736 2.79872 MTUS1 - Microtubule-associated tumor suppressor 1 homolog - Bos taurus (Bovine) - MTUS1 gene Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity). Taurus_UMD|evm.model.AC_000184.1.119 Q5BIP2 PGFRL_BOVIN 99.733 0.994681 1.00267 PDGFRL - Platelet-derived growth factor receptor-like protein precursor - Bos taurus (Bovine) - PDGFRL gene Taurus_UMD|evm.model.AC_000184.1.120 P52569 CTR2_HUMAN 91.641 0.995455 1.00304 SLC7A2 - Cationic amino acid transporter 2 - Homo sapiens (Human) - SLC7A2 gene Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport. Taurus_UMD|evm.model.AC_000184.1.121 Q9Y216 MTMR7_HUMAN 94.848 0.996974 1.00152 MTMR7 - Myotubularin-related protein 7 - Homo sapiens (Human) - MTMR7 gene Phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3-bisphosphate (Ins(1,3)P2). Taurus_UMD|evm.model.AC_000184.1.122 Q8NEZ2 VP37A_HUMAN 94.458 0.994975 1.00252 VPS37A - Vacuolar protein sorting-associated protein 37A - Homo sapiens (Human) - VPS37A gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Taurus_UMD|evm.model.AC_000184.1.123 Q60809 CNOT7_MOUSE 100.000 0.993007 1.00351 Cnot7 - CCR4-NOT transcription complex subunit 7 - Mus musculus (Mouse) - Cnot7 gene Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for miRNA-mediated mRNA deadenylation. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. Taurus_UMD|evm.model.AC_000184.1.124 Q9UIJ5 ZDHC2_HUMAN 95.062 0.928161 0.948229 ZDHHC2 - Palmitoyltransferase ZDHHC2 - Homo sapiens (Human) - ZDHHC2 gene Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18508921, PubMed:18296695, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844). Taurus_UMD|evm.model.AC_000184.1.125 Q86XE3 MICU3_HUMAN 90.056 0.996161 0.983019 MICU3 - Calcium uptake protein 3, mitochondrial - Homo sapiens (Human) - MICU3 gene May play a role in mitochondrial calcium uptake. Taurus_UMD|evm.model.AC_000184.1.126 Q9NP95 FGF20_HUMAN 98.104 0.990566 1.00474 FGF20 - Fibroblast growth factor 20 - Homo sapiens (Human) - FGF20 gene Neurotrophic factor that regulates central nervous development and function. Taurus_UMD|evm.model.AC_000184.1.127 Q9WTM5 RUVB2_MOUSE 89.189 0.522059 0.293737 Ruvbl2 - RuvB-like 2 - Mus musculus (Mouse) - Ruvbl2 gene Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (By similarity). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (By similarity). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (By similarity). May also inhibit the transcriptional activity of ATF2 (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (By similarity). May play a role in regulating the composition of the U5 snRNP complex (By similarity). Taurus_UMD|evm.model.AC_000184.1.128 P21758 MSRE_BOVIN 89.404 0.995074 0.896247 MSR1 - Macrophage scavenger receptor types I and II - Bos taurus (Bovine) - MSR1 gene Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Taurus_UMD|evm.model.AC_000184.1.129 Q5R893 H2B1_PONAB 92.537 0.680412 0.769841 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000184.1.130 Q8CGP1 H2B1K_MOUSE 91.837 0.436364 0.873016 H2bc12 - Histone H2B type 1-K - Mus musculus (Mouse) - H2bc12 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000184.1.131 Q32L57 TUSC3_BOVIN 99.712 0.994253 1.00288 TUSC3 - Tumor suppressor candidate 3 precursor - Bos taurus (Bovine) - TUSC3 gene Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Taurus_UMD|evm.model.AC_000184.1.133 Q96P11 NSUN5_HUMAN 87.600 0.783019 0.741259 NSUN5 - 28S rRNA (cytosine-C(5))-methyltransferase - Homo sapiens (Human) - NSUN5 gene S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA (PubMed:23913415, PubMed:31428936, PubMed:31722427). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (PubMed:31428936, PubMed:31722427). Required for corpus callosum and cerebral cortex development (By similarity). Taurus_UMD|evm.model.AC_000184.1.134 Q96LD1 SGCZ_HUMAN 96.923 0.984615 0.217391 SGCZ - Zeta-sarcoglycan - Homo sapiens (Human) - SGCZ gene Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability (By similarity). Taurus_UMD|evm.model.AC_000184.1.135 Q96LD1 SGCZ_HUMAN 96.923 0.984733 0.438127 SGCZ - Zeta-sarcoglycan - Homo sapiens (Human) - SGCZ gene Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability (By similarity). Taurus_UMD|evm.model.AC_000184.1.137 Q9JI44 DMAP1_MOUSE 61.017 0.467742 0.264957 Dmap1 - DNA methyltransferase 1-associated protein 1 - Mus musculus (Mouse) - Dmap1 gene Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity (By similarity). Taurus_UMD|evm.model.AC_000184.1.138 Q96LL4 CH048_HUMAN 66.142 0.950758 0.827586 C8orf48 - Uncharacterized protein C8orf48 - Homo sapiens (Human) - C8orf48 gene Taurus_UMD|evm.model.AC_000184.1.139 A7E300 RHG07_BOVIN 98.175 0.366443 0.669964 DLC1 - Rho GTPase-activating protein 7 - Bos taurus (Bovine) - DLC1 gene Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity). Taurus_UMD|evm.model.AC_000184.1.140 A7E300 RHG07_BOVIN 99.867 0.997347 0.678058 DLC1 - Rho GTPase-activating protein 7 - Bos taurus (Bovine) - DLC1 gene Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity). Taurus_UMD|evm.model.AC_000184.1.141 Q99880 H2B1L_HUMAN 71.429 0.915888 0.849206 H2BC13 - Histone H2B type 1-L - Homo sapiens (Human) - H2BC13 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000184.1.142 Q08DH3 TRM9B_BOVIN 99.688 0.790123 0.89404 TRMT9B - Probable tRNA methyltransferase 9B - Bos taurus (Bovine) - TRMT9B gene May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 (By similarity). Taurus_UMD|evm.model.AC_000184.1.143 Q17RB8 LONF1_HUMAN 92.495 0.676754 0.940492 LONRF1 - LON peptidase N-terminal domain and RING finger protein 1 - Homo sapiens (Human) - LONRF1 gene cytosol, protein polyubiquitination Taurus_UMD|evm.model.AC_000184.1.145 Q86YV5 PRAG1_HUMAN 78.273 0.990774 1.00213 PRAG1 - Inactive tyrosine-protein kinase PRAG1 - Homo sapiens (Human) - PRAG1 gene Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). Taurus_UMD|evm.model.AC_000184.1.147 Q9D7D7 CLD23_MOUSE 77.703 0.993197 0.993243 Cldn23 - Claudin-23 - Mus musculus (Mouse) - Cldn23 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Taurus_UMD|evm.model.AC_000184.1.148 A2ARV4 LRP2_MOUSE 43.386 0.0889645 0.441416 Lrp2 - Low-density lipoprotein receptor-related protein 2 precursor - Mus musculus (Mouse) - Lrp2 gene Multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins (PubMed:10766831). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (PubMed:22841573). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (PubMed:24825475). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (PubMed:17462596). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (PubMed:10052453). Mediates renal uptake of metallothionein-bound heavy metals (By similarity). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (PubMed:18174160). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (PubMed:28659595). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (PubMed:15623804). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (PubMed:22340494). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (PubMed:24639464). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (PubMed:20460439). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (PubMed:20637285). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (PubMed:22354480). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (PubMed:26439398). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (PubMed:16143106). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensin 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (PubMed:26822476). Required for normal hearing, possibly through interaction with estrogen in the inner ear (PubMed:17846082). Taurus_UMD|evm.model.AC_000184.1.149 Q9Y4C4 MFHA1_HUMAN 94.742 0.982107 0.956274 MFHAS1 - Malignant fibrous histiocytoma-amplified sequence 1 - Homo sapiens (Human) - MFHAS1 gene Probable GTP-binding protein (PubMed:24286120). Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways (PubMed:26599367, PubMed:28471450, PubMed:28609714). Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor (PubMed:28609714). Both inhibits and activates the TLR2-dependent signaling pathway (PubMed:26599367). Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway (PubMed:29168081). Also involved in erythrocyte differentiation through activation of the ERK1/ERK2 signaling pathway (PubMed:23327923). Taurus_UMD|evm.model.AC_000184.1.150 Q8IV48 ERI1_HUMAN 89.971 0.994286 1.00287 ERI1 - 3'-5' exoribonuclease 1 - Homo sapiens (Human) - ERI1 gene RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. Taurus_UMD|evm.model.AC_000184.1.151 A6QNP3 PPR3B_BOVIN 100.000 0.832353 1.19718 PPP1R3B - Protein phosphatase 1 regulatory subunit 3B - Bos taurus (Bovine) - PPP1R3B gene Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). Taurus_UMD|evm.model.AC_000184.1.152 O95271 TNKS1_HUMAN 98.870 0.998494 1.00075 TNKS - Poly [ADP-ribose] polymerase tankyrase-1 - Homo sapiens (Human) - TNKS gene Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). Taurus_UMD|evm.model.AC_000184.1.153 Q5D006 UBP11_RAT 52.941 0.664336 0.155266 Usp11 - Ubiquitin carboxyl-terminal hydrolase 11 - Rattus norvegicus (Rat) - Usp11 gene Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex. Taurus_UMD|evm.model.AC_000184.1.154 Q01988 UBP11_CANLF 86.395 0.637681 1.55056 USP11 - Ubiquitin carboxyl-terminal hydrolase 11 - Canis lupus familiaris (Dog) - USP11 gene Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex. Taurus_UMD|evm.model.AC_000184.1.155 Q62767 DUS4_RAT 96.962 0.994937 1 Dusp4 - Dual specificity protein phosphatase 4 - Rattus norvegicus (Rat) - Dusp4 gene Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. Taurus_UMD|evm.model.AC_000184.1.156 Q08E24 SARAF_BOVIN 100.000 0.994048 1.00299 SARAF - Store-operated calcium entry-associated regulatory factor precursor - Bos taurus (Bovine) - SARAF gene Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions (By similarity). Taurus_UMD|evm.model.AC_000184.1.157 Q32PD8 LERL1_BOVIN 100.000 0.804878 0.938931 LEPROTL1 - Leptin receptor overlapping transcript-like 1 - Bos taurus (Bovine) - LEPROTL1 gene Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity). Taurus_UMD|evm.model.AC_000184.1.158 Q96T53 MBOA4_HUMAN 79.310 0.995413 1.0023 MBOAT4 - Ghrelin O-acyltransferase - Homo sapiens (Human) - MBOAT4 gene Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid. Taurus_UMD|evm.model.AC_000184.1.159 Q148G7 DCTN6_BOVIN 100.000 0.989529 1.00526 DCTN6 - Dynactin subunit 6 - Bos taurus (Bovine) - DCTN6 gene dynactin complex, dynein complex binding, mitotic spindle organization Taurus_UMD|evm.model.AC_000184.1.160 Q5E995 RS6_BOVIN 85.542 0.991667 0.963855 RPS6 - 40S ribosomal protein S6 - Bos taurus (Bovine) - RPS6 gene Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Taurus_UMD|evm.model.AC_000184.1.161 Q93062 RBPMS_HUMAN 95.628 0.730924 1.27041 RBPMS - RNA-binding protein with multiple splicing - Homo sapiens (Human) - RBPMS gene Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403). Taurus_UMD|evm.model.AC_000184.1.163 Q2KJF9 T2EB_BOVIN 100.000 0.751131 0.764706 GTF2E2 - General transcription factor IIE subunit 2 - Bos taurus (Bovine) - GTF2E2 gene Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). Taurus_UMD|evm.model.AC_000184.1.164 P47791 GSHR_MOUSE 89.762 0.967667 0.866 Gsr - Glutathione reductase, mitochondrial precursor - Mus musculus (Mouse) - Gsr gene Maintains high levels of reduced glutathione in the cytosol. Taurus_UMD|evm.model.AC_000184.1.165 Q2TBH5 UBXN8_BOVIN 100.000 0.992754 1.00364 UBXN8 - UBX domain-containing protein 8 - Bos taurus (Bovine) - UBXN8 gene Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction (By similarity). Taurus_UMD|evm.model.AC_000184.1.166 Q0P594 PP2AB_BOVIN 100.000 0.993548 1.00324 PPP2CB - Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform - Bos taurus (Bovine) - PPP2CB gene PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Taurus_UMD|evm.model.AC_000184.1.167 Q9BXT5 TEX15_HUMAN 62.036 0.788822 1.07135 TEX15 - Testis-expressed protein 15 - Homo sapiens (Human) - TEX15 gene Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair (By similarity). Essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (By similarity). PIWIL4-piRNA binds to nascent transposon transcripts and interacts with TEX15, which may in turn recruit the epigenetic silencing machinery to the transposon loci (By similarity). Not required for piRNA biosynthesis (By similarity). Taurus_UMD|evm.model.AC_000184.1.168 Q9UJV8 PURG_HUMAN 96.857 0.994302 1.01153 PURG - Purine-rich element-binding protein gamma - Homo sapiens (Human) - PURG gene nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, purine-rich negative regulatory element binding, RNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000184.1.169 Q14191 WRN_HUMAN 72.292 0.998575 0.980447 WRN - Werner syndrome ATP-dependent helicase - Homo sapiens (Human) - WRN gene Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation. Taurus_UMD|evm.model.AC_000184.1.171 Q02297 NRG1_HUMAN 89.904 0.9613 1.00937 NRG1 - Pro-neuregulin-1, membrane-bound isoform precursor - Homo sapiens (Human) - NRG1 gene Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). Taurus_UMD|evm.model.AC_000184.1.172 Q2HJF1 RM53_BOVIN 96.296 0.638554 0.741071 MRPL53 - 39S ribosomal protein L53, mitochondrial precursor - Bos taurus (Bovine) - MRPL53 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Taurus_UMD|evm.model.AC_000184.1.173 Q6A198 FUT10_BOVIN 93.515 0.995585 0.947699 FUT10 - Alpha-(1,3)-fucosyltransferase 10 - Bos taurus (Bovine) - FUT10 gene Probable fucosyltransferase. Taurus_UMD|evm.model.AC_000184.1.174 Q1RML7 MAK16_BOVIN 100.000 0.993311 1.00336 MAK16 - Protein MAK16 homolog - Bos taurus (Bovine) - MAK16 gene nucleolus, preribosome, large subunit precursor, maturation of 5.8S rRNA, maturation of LSU-rRNA Taurus_UMD|evm.model.AC_000184.1.175 Q6NXR4 TTI2_HUMAN 79.528 0.996071 1.00197 TTI2 - TELO2-interacting protein 2 - Homo sapiens (Human) - TTI2 gene Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Taurus_UMD|evm.model.AC_000184.1.176 Q8BP31 RN122_MOUSE 97.710 0.984848 0.851613 Rnf122 - RING finger protein 122 - Mus musculus (Mouse) - Rnf122 gene May induce necrosis and apoptosis. May play a role in cell viability (By similarity). Taurus_UMD|evm.model.AC_000184.1.177 Q17QJ3 DUS26_BOVIN 100.000 0.763636 1.30332 DUSP26 - Dual specificity protein phosphatase 26 - Bos taurus (Bovine) - DUSP26 gene Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Taurus_UMD|evm.model.AC_000184.1.180 Q9GZU8 PIP30_HUMAN 94.094 0.992126 1 PSME3IP1 - PSME3-interacting protein - Homo sapiens (Human) - PSME3IP1 gene Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus. Taurus_UMD|evm.model.AC_000184.1.181 Q6UXZ4 UNC5D_HUMAN 97.715 0.962264 1.00105 UNC5D - Netrin receptor UNC5D precursor - Homo sapiens (Human) - UNC5D gene Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity). Taurus_UMD|evm.model.AC_000184.1.183 A8MYU2 KCNU1_HUMAN 84.818 0.482387 0.889469 KCNU1 - Potassium channel subfamily U member 1 - Homo sapiens (Human) - KCNU1 gene Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina. Taurus_UMD|evm.model.AC_000184.1.184 Q6KAR6 EXOC3_MOUSE 60.870 0.283333 0.317881 Exoc3 - Exocyst complex component 3 - Mus musculus (Mouse) - Exoc3 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Taurus_UMD|evm.model.AC_000184.1.186 Q8IXU6 S35F2_HUMAN 96.939 0.757812 0.342246 SLC35F2 - Solute carrier family 35 member F2 - Homo sapiens (Human) - SLC35F2 gene Putative solute transporter. Taurus_UMD|evm.model.AC_000184.1.188 Q9H7S9 ZN703_HUMAN 91.837 0.502249 1.13051 ZNF703 - Zinc finger protein 703 - Homo sapiens (Human) - ZNF703 gene Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. Taurus_UMD|evm.model.AC_000184.1.189 Q5E983 EF1B_BOVIN 80.172 0.950413 0.537778 EEF1B - Elongation factor 1-beta - Bos taurus (Bovine) - EEF1B gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Taurus_UMD|evm.model.AC_000184.1.190 Q1RMU4 ERLN2_BOVIN 100.000 0.954674 1.04438 ERLIN2 - Erlin-2 - Bos taurus (Bovine) - ERLIN2 gene Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity). Taurus_UMD|evm.model.AC_000184.1.191 Q3T0G5 PLPHP_BOVIN 100.000 0.992701 1.00366 PLPBP - Pyridoxal phosphate homeostasis protein - Bos taurus (Bovine) - PLPBP gene Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. Taurus_UMD|evm.model.AC_000184.1.192 Q96PE1 AGRA2_HUMAN 83.706 0.726841 0.629297 ADGRA2 - Adhesion G protein-coupled receptor A2 precursor - Homo sapiens (Human) - ADGRA2 gene Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). Taurus_UMD|evm.model.AC_000184.1.193 Q29S07 BRF2_BOVIN 100.000 0.995261 1.00238 BRF2 - Transcription factor IIIB 50 kDa subunit - Bos taurus (Bovine) - BRF2 gene General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress. Taurus_UMD|evm.model.AC_000184.1.194 Q96PE1 AGRA2_HUMAN 94.704 0.891365 0.268311 ADGRA2 - Adhesion G protein-coupled receptor A2 precursor - Homo sapiens (Human) - ADGRA2 gene Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). Taurus_UMD|evm.model.AC_000184.1.195 Q3B7T9 RFIP1_RAT 84.348 0.0933661 1.88426 Rab11fip1 - Rab11 family-interacting protein 1 - Rattus norvegicus (Rat) - Rab11fip1 gene A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and phagocytosis (By similarity). Taurus_UMD|evm.model.AC_000184.1.196 Q2T9S8 AATC2_BOVIN 100.000 0.995098 1.00246 GOT1L1 - Putative aspartate aminotransferase, cytoplasmic 2 - Bos taurus (Bovine) - GOT1L1 gene cytosol, L-aspartate:2-oxoglutarate aminotransferase activity, aspartate biosynthetic process Taurus_UMD|evm.model.AC_000184.1.197 P46626 ADRB3_BOVIN 100.000 0.995 0.987654 ADRB3 - Beta-3 adrenergic receptor - Bos taurus (Bovine) - ADRB3 gene Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. Taurus_UMD|evm.model.AC_000184.1.198 Q0P5A7 4EBP1_BOVIN 100.000 0.983193 1.00847 EIF4EBP1 - Eukaryotic translation initiation factor 4E-binding protein 1 - Bos taurus (Bovine) - EIF4EBP1 gene Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Taurus_UMD|evm.model.AC_000184.1.199 Q9UBL3 ASH2L_HUMAN 96.343 0.996825 1.00318 ASH2L - Set1/Ash2 histone methyltransferase complex subunit ASH2 - Homo sapiens (Human) - ASH2L gene Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). Taurus_UMD|evm.model.AC_000184.1.200 Q28918 STAR_BOVIN 100.000 0.993007 1.00351 STAR - Steroidogenic acute regulatory protein, mitochondrial precursor - Bos taurus (Bovine) - STAR gene Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). Taurus_UMD|evm.model.AC_000184.1.201 Q5E9Z8 LSM1_BOVIN 100.000 0.985075 1.00752 LSM1 - U6 snRNA-associated Sm-like protein LSm1 - Bos taurus (Bovine) - LSM1 gene Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). Taurus_UMD|evm.model.AC_000184.1.202 Q8NEB5 PLPP5_HUMAN 86.008 0.913208 1.00379 PLPP5 - Phospholipid phosphatase 5 - Homo sapiens (Human) - PLPP5 gene Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules (PubMed:17590538). Taurus_UMD|evm.model.AC_000184.1.203 Q9BZ95 NSD3_HUMAN 94.536 0.869048 0.292276 NSD3 - Histone-lysine N-methyltransferase NSD3 - Homo sapiens (Human) - NSD3 gene Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. Taurus_UMD|evm.model.AC_000184.1.204 O94830 DDHD2_HUMAN 92.453 0.808057 1.18706 DDHD2 - Phospholipase DDHD2 - Homo sapiens (Human) - DDHD2 gene Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane. Taurus_UMD|evm.model.AC_000184.1.205 Q9BZ95 NSD3_HUMAN 93.532 0.982828 0.688935 NSD3 - Histone-lysine N-methyltransferase NSD3 - Homo sapiens (Human) - NSD3 gene Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. Taurus_UMD|evm.model.AC_000184.1.206 Q2VYF4 LETM2_HUMAN 85.930 0.921114 0.8778 LETM2 - LETM1 domain-containing protein LETM2, mitochondrial precursor - Homo sapiens (Human) - LETM2 gene cellular metal ion homeostasis Taurus_UMD|evm.model.AC_000184.1.207 P11362 FGFR1_HUMAN 98.297 0.997558 0.99635 FGFR1 - Fibroblast growth factor receptor 1 precursor - Homo sapiens (Human) - FGFR1 gene Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. Taurus_UMD|evm.model.AC_000184.1.209 O95359 TACC2_HUMAN 70.370 0.304102 0.239824 TACC2 - Transforming acidic coiled-coil-containing protein 2 - Homo sapiens (Human) - TACC2 gene Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. Taurus_UMD|evm.model.AC_000184.1.211 Q3ZBA3 PKHA2_BOVIN 100.000 0.86802 0.927059 PLEKHA2 - Pleckstrin homology domain-containing family A member 2 - Bos taurus (Bovine) - PLEKHA2 gene Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). Taurus_UMD|evm.model.AC_000184.1.212 E1BJW1 HTRA4_BOVIN 99.587 0.995859 0.997934 HTRA4 - Serine protease HTR4 precursor - Bos taurus (Bovine) - HTRA4 gene Serine protease. Taurus_UMD|evm.model.AC_000184.1.213 Q2TA35 TM2D2_BOVIN 100.000 0.990698 1.00467 TM2D2 - TM2 domain-containing protein 2 precursor - Bos taurus (Bovine) - TM2D2 gene Taurus_UMD|evm.model.AC_000184.1.214 Q13443 ADAM9_HUMAN 85.871 0.997567 1.00366 ADAM9 - Disintegrin and metalloproteinase domain-containing protein 9 precursor - Homo sapiens (Human) - ADAM9 gene Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. Taurus_UMD|evm.model.AC_000184.1.215 Q8TC27 ADA32_HUMAN 59.662 0.829358 0.692503 ADAM32 - Disintegrin and metalloproteinase domain-containing protein 32 precursor - Homo sapiens (Human) - ADAM32 gene May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. Taurus_UMD|evm.model.AC_000184.1.216 Q28483 ADAM5_MACFA 60.246 0.962716 0.993386 ADAM5 - Disintegrin and metalloproteinase domain-containing protein 5 precursor - Macaca fascicularis (Crab-eating macaque) - ADAM5 gene This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity). Taurus_UMD|evm.model.AC_000184.1.217 Q5R9C3 GPBL1_PONAB 71.146 0.977974 0.478903 GPBP1L1 - Vasculin-like protein 1 - Pongo abelii (Sumatran orangutan) - GPBP1L1 gene Possible transcription factor. Taurus_UMD|evm.model.AC_000184.1.218 O77780 ADAM2_BOVIN 85.271 0.913897 0.888591 ADAM2 - Disintegrin and metalloproteinase domain-containing protein 2 precursor - Bos taurus (Bovine) - ADAM2 gene Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). Taurus_UMD|evm.model.AC_000184.1.219 F8VQ03 ADAM3_MOUSE 51.696 0.974044 0.890511 Adam3 - A disintegrin and metallopeptidase domain 3 precursor - Mus musculus (Mouse) - Adam3 gene Involved in fertilization by controlling sperm migration into oviduct. Taurus_UMD|evm.model.AC_000184.1.220 Q9Y3Q7 ADA18_HUMAN 66.436 0.936261 0.955345 ADAM18 - Disintegrin and metalloproteinase domain-containing protein 18 precursor - Homo sapiens (Human) - ADAM18 gene Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity). Taurus_UMD|evm.model.AC_000184.1.221 P14902 I23O1_HUMAN 69.383 0.982801 1.00993 IDO1 - Indoleamine 2,3-dioxygenase 1 - Homo sapiens (Human) - IDO1 gene Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885). Taurus_UMD|evm.model.AC_000184.1.222 Q6ZQW0 I23O2_HUMAN 76.167 0.995098 0.971429 IDO2 - Indoleamine 2,3-dioxygenase 2 - Homo sapiens (Human) - IDO2 gene Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885). Taurus_UMD|evm.model.AC_000184.1.223 Q5E969 TCIM_BOVIN 100.000 0.981308 1.00943 TCIM - Transcriptional and immune response regulator - Bos taurus (Bovine) - TCIM gene Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (By similarity). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (By similarity). Taurus_UMD|evm.model.AC_000184.1.224 Q6ZWJ1 STXB4_HUMAN 87.838 0.293173 0.450271 STXBP4 - Syntaxin-binding protein 4 - Homo sapiens (Human) - STXBP4 gene Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). Taurus_UMD|evm.model.AC_000184.1.226 Q0VD35 ZMAT4_BOVIN 100.000 0.991304 1.00437 ZMAT4 - Zinc finger matrin-type protein 4 - Bos taurus (Bovine) - ZMAT4 gene Taurus_UMD|evm.model.AC_000184.1.227 P62317 SMD2_MOUSE 68.333 0.655556 0.762712 Snrpd2 - Small nuclear ribonucleoprotein Sm D2 - Mus musculus (Mouse) - Snrpd2 gene Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. Taurus_UMD|evm.model.AC_000184.1.228 O19116 SFRP1_BOVIN 99.675 0.993528 1.00325 SFRP1 - Secreted frizzled-related protein 1 precursor - Bos taurus (Bovine) - SFRP1 gene Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. Taurus_UMD|evm.model.AC_000184.1.229 Q7Z5G4 GOGA7_HUMAN 100.000 0.871795 1.13869 GOLGA7 - Golgin subfamily A member 7 - Homo sapiens (Human) - GOLGA7 gene May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. Taurus_UMD|evm.model.AC_000184.1.230 A2VE40 SLD5_BOVIN 100.000 0.672727 1.47982 GINS4 - DNA replication complex GINS protein SLD5 - Bos taurus (Bovine) - GINS4 gene The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA. Taurus_UMD|evm.model.AC_000184.1.232 A3FPG8 GPAT4_BOVIN 99.781 0.863378 1.1557 GPAT4 - Glycerol-3-phosphate acyltransferase 4 precursor - Bos taurus (Bovine) - GPAT4 gene Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (By similarity). Active against both saturated and unsaturated long-chain fatty acyl-CoAs (By similarity). Taurus_UMD|evm.model.AC_000184.1.233 Q3UHX8 NKX63_MOUSE 89.773 0.992424 1.00763 Nkx6-3 - Homeobox protein Nkx-6.3 - Mus musculus (Mouse) - Nkx6-3 gene Putative transcription factor, which may be involved in patterning of central nervous system and pancreas. Taurus_UMD|evm.model.AC_000184.1.234 P16157 ANK1_HUMAN 89.114 0.97065 1.01435 ANK1 - Ankyrin-1 - Homo sapiens (Human) - ANK1 gene Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Taurus_UMD|evm.model.AC_000184.1.236 Q92794 KAT6A_HUMAN 88.182 0.82318 1.00749 KAT6A - Histone acetyltransferase KAT6A - Homo sapiens (Human) - KAT6A gene Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. Taurus_UMD|evm.model.AC_000184.1.237 P53677 AP3M2_HUMAN 99.761 0.877895 1.13636 AP3M2 - AP-3 complex subunit mu-2 - Homo sapiens (Human) - AP3M2 gene Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Taurus_UMD|evm.model.AC_000184.1.238 Q28198 TPA_BOVIN 96.479 0.855204 1.17138 PLAT - Tissue-type plasminogen activator precursor - Bos taurus (Bovine) - PLAT gene Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy. Taurus_UMD|evm.model.AC_000184.1.239 Q95KV0 IKKB_BOVIN 100.000 0.997358 1.00132 IKBKB - Inhibitor of nuclear factor kappa-B kinase subunit beta - Bos taurus (Bovine) - IKBKB gene Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation (By similarity). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (By similarity). Taurus_UMD|evm.model.AC_000184.1.240 Q27958 DPOLB_BOVIN 100.000 0.994048 1.00299 POLB - DNA polymerase beta - Bos taurus (Bovine) - POLB gene Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases (By similarity). Taurus_UMD|evm.model.AC_000184.1.241 Q9UBT3 DKK4_HUMAN 53.939 0.636719 1.14286 DKK4 - Dickkopf-related protein 4 precursor - Homo sapiens (Human) - DKK4 gene Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). Taurus_UMD|evm.model.AC_000184.1.242 Q9MZ13 VDAC3_BOVIN 100.000 0.992958 1.00353 VDAC3 - Voltage-dependent anion-selective channel protein 3 - Bos taurus (Bovine) - VDAC3 gene Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. Taurus_UMD|evm.model.AC_000184.1.243 A1A4I1 S20A2_BOVIN 99.845 0.996904 1.00155 SLC20A2 - Sodium-dependent phosphate transporter 2 - Bos taurus (Bovine) - SLC20A2 gene Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not significantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage calcification and vascular calcification. Functions as a retroviral receptor (By similarity). Taurus_UMD|evm.model.AC_000184.1.244 A5D7B5 SMI19_BOVIN 100.000 0.981481 1.00935 SMIM19 - Small integral membrane protein 19 - Bos taurus (Bovine) - SMIM19 gene Taurus_UMD|evm.model.AC_000184.1.245 Q5IS75 ACHB3_PANTR 90.175 0.995643 1.00218 CHRNB3 - Neuronal acetylcholine receptor subunit beta-3 precursor - Pan troglodytes (Chimpanzee) - CHRNB3 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Taurus_UMD|evm.model.AC_000184.1.246 Q15825 ACHA6_HUMAN 87.247 0.99596 1.00202 CHRNA6 - Neuronal acetylcholine receptor subunit alpha-6 precursor - Homo sapiens (Human) - CHRNA6 gene After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Taurus_UMD|evm.model.AC_000184.1.247 Q3T0G1 THAP1_BOVIN 100.000 0.990654 1.00469 THAP1 - THAP domain-containing protein 1 - Bos taurus (Bovine) - THAP1 gene DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity). Taurus_UMD|evm.model.AC_000184.1.248 F1MK05 RN170_BOVIN 99.614 0.992278 1 RNF170 - E3 ubiquitin-protein ligase RNF170 - Bos taurus (Bovine) - RNF170 gene E3 ubiquitin-protein ligase. Plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Taurus_UMD|evm.model.AC_000184.1.249 Q86VS8 HOOK3_HUMAN 98.056 0.997226 1.00418 HOOK3 - Protein Hook homolog 3 - Homo sapiens (Human) - HOOK3 gene Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Taurus_UMD|evm.model.AC_000184.1.250 P29702 FNTA_BOVIN 99.733 0.994681 1.00267 FNTA - Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha - Bos taurus (Bovine) - FNTA gene Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation (By similarity). Taurus_UMD|evm.model.AC_000184.1.251 Q95JJ0 SG196_MACFA 77.714 0.994302 1.00286 POMK - Protein O-mannose kinase - Macaca fascicularis (Crab-eating macaque) - POMK gene Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif (By similarity). Taurus_UMD|evm.model.AC_000184.1.252 Q68CP4 HGNAT_HUMAN 83.054 0.944089 0.944193 HGSNAT - Heparan-alpha-glucosaminide N-acetyltransferase - Homo sapiens (Human) - HGSNAT gene Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. Taurus_UMD|evm.model.AC_000184.1.254 Q9NVR2 INT10_HUMAN 96.620 0.997187 1.00141 INTS10 - Integrator complex subunit 10 - Homo sapiens (Human) - INTS10 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267). Taurus_UMD|evm.model.AC_000184.1.257 Q8TDX6 CGAT1_HUMAN 85.164 0.975238 0.986842 CSGALNACT1 - Chondroitin sulfate N-acetylgalactosaminyltransferase 1 - Homo sapiens (Human) - CSGALNACT1 gene Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758, PubMed:31705726). Moreover, is involved in the metabolism of aggrecan (By similarity). Taurus_UMD|evm.model.AC_000184.1.258 Q6AYC8 SH24A_RAT 71.158 0.995283 1.00474 Sh2d4a - SH2 domain-containing protein 4A - Rattus norvegicus (Rat) - Sh2d4a gene Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function (By similarity). Taurus_UMD|evm.model.AC_000184.1.260 P57016 LAD1_MOUSE 56.463 0.771277 0.356061 Lad1 - Ladinin-1 - Mus musculus (Mouse) - Lad1 gene Anchoring filament protein which is a component of the basement membrane zone. Taurus_UMD|evm.model.AC_000184.1.261 Q9NYI0 PSD3_HUMAN 80.179 0.986869 0.944656 PSD3 - PH and SEC7 domain-containing protein 3 - Homo sapiens (Human) - PSD3 gene Guanine nucleotide exchange factor for ARF6. Taurus_UMD|evm.model.AC_000184.1.262 Q1JPA6 ARY1_BOVIN 100.000 0.993127 1.00345 NAT1 - Arylamine N-acetyltransferase 1 - Bos taurus (Bovine) - NAT1 gene Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Taurus_UMD|evm.model.AC_000184.1.263 A6H789 LRC3B_BOVIN 100.000 0.992308 1.00386 LRRC3B - Leucine-rich repeat-containing protein 3B precursor - Bos taurus (Bovine) - LRRC3B gene extracellular matrix, extracellular space Taurus_UMD|evm.model.AC_000184.1.266 Q0VCA7 OXSM_BOVIN 99.783 0.995662 1.00217 OXSM - 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial precursor - Bos taurus (Bovine) - OXSM gene May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Taurus_UMD|evm.model.AC_000184.1.267 Q96IV0 NGLY1_HUMAN 86.006 0.965046 1.00612 NGLY1 - Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase - Homo sapiens (Human) - NGLY1 gene Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. Taurus_UMD|evm.model.AC_000184.1.269 Q02880 TOP2B_HUMAN 95.379 0.98647 1 TOP2B - DNA topoisomerase 2-beta - Homo sapiens (Human) - TOP2B gene Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Taurus_UMD|evm.model.AC_000184.1.270 P22605 RARB_MOUSE 71.906 0.829861 0.59751 Rarb - Retinoic acid receptor beta - Mus musculus (Mouse) - Rarb gene Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (PubMed:19389355). Taurus_UMD|evm.model.AC_000184.1.271 P18515 RARB_NOTVI 98.182 0.352941 0.968354 RARB - Retinoic acid receptor beta - Notophthalmus viridescens (Eastern newt) - RARB gene Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Taurus_UMD|evm.model.AC_000184.1.273 P22605 RARB_MOUSE 84.746 0.39726 0.302905 Rarb - Retinoic acid receptor beta - Mus musculus (Mouse) - Rarb gene Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (PubMed:19389355). Taurus_UMD|evm.model.AC_000184.1.276 P33991 MCM4_HUMAN 95.890 0.515957 0.653534 MCM4 - DNA replication licensing factor MCM4 - Homo sapiens (Human) - MCM4 gene Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Taurus_UMD|evm.model.AC_000184.1.277 Q5RCP8 H2B2E_PONAB 95.238 0.984252 1.00794 H2BC21 - Histone H2B type 2-E - Pongo abelii (Sumatran orangutan) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000184.1.279 Q28571 THB_SHEEP 99.024 0.88913 1.11922 THRB - Thyroid hormone receptor beta - Ovis aries (Sheep) - THRB gene Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Taurus_UMD|evm.model.AC_000184.1.280 Q14995 NR1D2_HUMAN 86.919 0.986371 1.01382 NR1D2 - Nuclear receptor subfamily 1 group D member 2 - Homo sapiens (Human) - NR1D2 gene Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle (By similarity). Plays a role in the regulation of circadian sleep/wake cycle; essential for maintaining wakefulness during the dark phase or active period (By similarity). Key regulator of skeletal muscle mitochondrial function; negatively regulates the skeletal muscle expression of core clock genes and genes involved in mitochondrial biogenesis, fatty acid beta-oxidation and lipid metabolism (By similarity). May play a role in the circadian control of neutrophilic inflammation in the lung (By similarity). Taurus_UMD|evm.model.AC_000184.1.281 P61314 RL15_RAT 100.000 0.990244 1.0049 Rpl15 - 60S ribosomal protein L15 - Rattus norvegicus (Rat) - Rpl15 gene A band, cytosolic large ribosomal subunit, nucleus, RNA binding, structural constituent of ribosome, cytoplasmic translation, response to ethanol Taurus_UMD|evm.model.AC_000184.1.282 Q9BH04 KBRS1_MACFA 97.917 0.989637 1.00521 NKIRAS1 - NF-kappa-B inhibitor-interacting Ras-like protein 1 - Macaca fascicularis (Crab-eating macaque) - NKIRAS1 gene Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). Taurus_UMD|evm.model.AC_000184.1.283 P51965 UB2E1_HUMAN 100.000 0.987261 0.813472 UBE2E1 - Ubiquitin-conjugating enzyme E2 E1 - Homo sapiens (Human) - UBE2E1 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Taurus_UMD|evm.model.AC_000184.1.285 Q96LR5 UB2E2_HUMAN 100.000 0.984127 0.626866 UBE2E2 - Ubiquitin-conjugating enzyme E2 E2 - Homo sapiens (Human) - UBE2E2 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein. Taurus_UMD|evm.model.AC_000184.1.287 A2Q0Z0 EF1A1_HORSE 55.061 0.930894 0.532468 EEF1A1 - Elongation factor 1-alpha 1 - Equus caballus (Horse) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000184.1.291 Q6PBT9 Z385B_DANRE 65.217 0.28481 0.321138 znf385b - Zinc finger protein 385B - Danio rerio (Zebrafish) - znf385b gene May play a role in p53/TP53-mediated apoptosis. Taurus_UMD|evm.model.AC_000184.1.294 Q9H6B1 Z385D_HUMAN 95.506 0.988764 0.225316 ZNF385D - Zinc finger protein 385D - Homo sapiens (Human) - ZNF385D gene nucleus, sequence-specific double-stranded DNA binding Taurus_UMD|evm.model.AC_000184.1.295 Q9UFH2 DYH17_HUMAN 84.375 0.424658 0.0163604 DNAH17 - Dynein axonemal heavy chain 17 - Homo sapiens (Human) - DNAH17 gene Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (Probable). Plays a major role in sperm motility, implicated in sperm flagellar assembly and beating (PubMed:31178125). Taurus_UMD|evm.model.AC_000185.1.2 Q2TBH7 RAB4A_BOVIN 100.000 0.990868 1.00459 RAB4A - Ras-related protein Rab-4A - Bos taurus (Bovine) - RAB4A gene Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (By similarity). Involved in protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). Taurus_UMD|evm.model.AC_000185.1.3 Q6IQ19 CCSAP_HUMAN 69.343 0.992537 0.992593 CCSAP - Centriole, cilia and spindle-associated protein - Homo sapiens (Human) - CCSAP gene Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (PubMed:26562023). May play a role in embryonic development. May be required for proper cilia beating (By similarity). Taurus_UMD|evm.model.AC_000185.1.4 A6YRY8 RSSA_SHEEP 78.750 0.975309 0.274576 RPSA - 40S ribosomal protein SA - Ovis aries (Sheep) - RPSA gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. Taurus_UMD|evm.model.AC_000185.1.5 O00370 LORF2_HUMAN 70.309 0.670927 0.49098 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000185.1.6 P68136 ACTS_RAT 100.000 0.994709 1.00265 Acta1 - Actin, alpha skeletal muscle precursor - Rattus norvegicus (Rat) - Acta1 gene Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Taurus_UMD|evm.model.AC_000185.1.7 Q8WUM0 NU133_HUMAN 90.052 0.998271 1.00087 NUP133 - Nuclear pore complex protein Nup133 - Homo sapiens (Human) - NUP133 gene Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). Taurus_UMD|evm.model.AC_000185.1.8 Q9NRK6 ABCBA_HUMAN 89.070 0.941538 0.880759 ABCB10 - ATP-binding cassette sub-family B member 10, mitochondrial precursor - Homo sapiens (Human) - ABCB10 gene Catalyzes the export of an unknown physiological substrate from the mitochondrial matrix to the cytosol in an ATP-dependent manner (PubMed:33253225). May also transport the heme analog Zn (II) mesoporphyrin (ZnMP) in an ATP dependent manner but can't export the heme precursor 5-aminolevulinic acid (ALA) from mitochondria (PubMed:33253225). Plays a role in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). In turn participates in hemoglobin synthesis and also protects against oxidative stress (PubMed:28808058, PubMed:22085049). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (PubMed:28315685). Taurus_UMD|evm.model.AC_000185.1.9 O75529 TAF5L_HUMAN 86.418 0.996317 0.921902 TAF5L - TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L - Homo sapiens (Human) - TAF5L gene Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By similarity). Taurus_UMD|evm.model.AC_000185.1.10 Q14146 URB2_HUMAN 73.539 0.9819 1.01509 URB2 - Unhealthy ribosome biogenesis protein 2 homolog - Homo sapiens (Human) - URB2 gene aggresome, midbody, nucleolus, ribosome biogenesis Taurus_UMD|evm.model.AC_000185.1.11 Q5RA31 TOM20_PONAB 47.297 0.978261 0.634483 TOMM20 - Mitochondrial import receptor subunit TOM20 homolog - Pongo abelii (Sumatran orangutan) - TOMM20 gene Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. Taurus_UMD|evm.model.AC_000185.1.12 Q10471 GALT2_HUMAN 98.070 0.994755 1.00175 GALNT2 - Polypeptide N-acetylgalactosaminyltransferase 2 - Homo sapiens (Human) - GALNT2 gene Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates to the regulation of HDL-C metabolism (PubMed:27508872, PubMed:32293671). Taurus_UMD|evm.model.AC_000185.1.13 D3YZI9 PGBD5_MOUSE 91.451 0.978516 0.978967 Pgbd5 - PiggyBac transposable element-derived protein 5 - Mus musculus (Mouse) - Pgbd5 gene Transposase that mediates sequence-specific genomic rearrangements. Taurus_UMD|evm.model.AC_000185.1.14 Q9NZ56 FMN2_HUMAN 86.243 0.330986 0.329849 FMN2 - Formin-2 - Homo sapiens (Human) - FMN2 gene Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:22330775, PubMed:21730168). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:22330775, PubMed:21730168). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). Taurus_UMD|evm.model.AC_000185.1.16 A5D7J5 RHOU_BOVIN 100.000 0.992188 1.00392 RHOU - Rho-related GTP-binding protein RhoU - Bos taurus (Bovine) - RHOU gene Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity). Taurus_UMD|evm.model.AC_000185.1.17 Q8NGL2 OR5L1_HUMAN 77.586 0.95 0.192926 OR5L1 - Olfactory receptor 5L1 - Homo sapiens (Human) - OR5L1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000185.1.18 Q8NGL7 OR4P4_HUMAN 54.545 0.936306 0.503205 OR4P4 - Olfactory receptor 4P4 - Homo sapiens (Human) - OR4P4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000185.1.19 Q9NRI5 DISC1_HUMAN 47.516 0.664474 0.533958 DISC1 - Disrupted in schizophrenia 1 protein - Homo sapiens (Human) - DISC1 gene Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19502360, PubMed:19303846). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (PubMed:18955030). Taurus_UMD|evm.model.AC_000185.1.21 Q5RC21 TSNAX_PONAB 97.241 0.993127 1.00345 TSNAX - Translin-associated protein X - Pongo abelii (Sumatran orangutan) - TSNAX gene Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity). Taurus_UMD|evm.model.AC_000185.1.22 P09244 TBB7_CHICK 95.571 0.961798 1.00225 Tubulin beta-7 chain - Gallus gallus (Chicken) Taurus_UMD|evm.model.AC_000185.1.23 Q3T013 BNI3L_BOVIN 99.543 0.990909 1.00457 BNIP3L - BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like - Bos taurus (Bovine) - BNIP3L gene Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May function as a tumor suppressor (By similarity). Taurus_UMD|evm.model.AC_000185.1.24 Q9GZT9 EGLN1_HUMAN 77.994 0.989865 0.694836 EGLN1 - Egl nine homolog 1 - Homo sapiens (Human) - EGLN1 gene Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif. Taurus_UMD|evm.model.AC_000185.1.25 Q9GZT9 EGLN1_HUMAN 97.656 0.984496 0.302817 EGLN1 - Egl nine homolog 1 - Homo sapiens (Human) - EGLN1 gene Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif. Taurus_UMD|evm.model.AC_000185.1.26 A5D979 SPRTN_BOVIN 100.000 0.954813 1.04517 SPRTN - DNA-dependent metalloprotease SPRTN - Bos taurus (Bovine) - SPRTN gene DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis. Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as TOP1, TOP2A, histones H3 and H4 (By similarity). Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs. SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity). Involved in recruitment of VCP/p97 to sites of DNA damage. Also acts as an activator of CHEK1 during normal DNA replication by mediating proteolytic cleavage of CHEK1, thereby promoting CHEK1 removal from chromatin and subsequent activation. Does not activate CHEK1 in response to DNA damage. May also act as a 'reader' of ubiquitinated PCNA: recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis (By similarity). Taurus_UMD|evm.model.AC_000185.1.27 A4IF89 EXOC8_BOVIN 100.000 0.997245 1.00138 EXOC8 - Exocyst complex component 8 - Bos taurus (Bovine) - EXOC8 gene Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Taurus_UMD|evm.model.AC_000185.1.28 A4IF87 GNPAT_BOVIN 99.831 0.954839 0.911765 GNPAT - Dihydroxyacetone phosphate acyltransferase - Bos taurus (Bovine) - GNPAT gene Dihydroxyacetonephosphate acyltransferase involved in plasmalogen biosynthesis. Taurus_UMD|evm.model.AC_000185.1.29 Q8NDD1 CA131_HUMAN 71.134 0.993127 0.993174 C1orf131 - Uncharacterized protein C1orf131 - Homo sapiens (Human) - C1orf131 gene chromosome, RNA binding Taurus_UMD|evm.model.AC_000185.1.30 Q6ZTA4 TRI67_HUMAN 98.623 0.509859 0.906769 TRIM67 - Tripartite motif-containing protein 67 - Homo sapiens (Human) - TRIM67 gene regulation of cellular protein localization Taurus_UMD|evm.model.AC_000185.1.31 A6QQF7 FA89A_BOVIN 100.000 0.988827 1.00562 FAM89A - Protein FAM89A - Bos taurus (Bovine) - FAM89A gene Taurus_UMD|evm.model.AC_000185.1.32 Q3SZW3 ARV1_BOVIN 99.645 0.992933 1.00355 ARV1 - Protein ARV1 - Bos taurus (Bovine) - ARV1 gene Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membranes. Taurus_UMD|evm.model.AC_000185.1.33 Q8NBP0 TTC13_HUMAN 98.488 0.997672 0.998837 TTC13 - Tetratricopeptide repeat protein 13 - Homo sapiens (Human) - TTC13 gene Taurus_UMD|evm.model.AC_000185.1.34 Q58CU6 CA198_BOVIN 100.000 0.908676 0.673846 Uncharacterized protein C1orf198 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000185.1.35 Q5VWM4 PRAM8_HUMAN 51.724 0.248555 0.729958 PRAMEF8 - PRAME family member 8 - Homo sapiens (Human) - PRAMEF8 gene cytoplasm Taurus_UMD|evm.model.AC_000185.1.36 Q9NZ56 FMN2_HUMAN 86.777 0.12024 0.579559 FMN2 - Formin-2 - Homo sapiens (Human) - FMN2 gene Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:22330775, PubMed:21730168). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:22330775, PubMed:21730168). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). Taurus_UMD|evm.model.AC_000185.1.37 Q9NZ56 FMN2_HUMAN 96.530 0.960486 0.191057 FMN2 - Formin-2 - Homo sapiens (Human) - FMN2 gene Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:22330775, PubMed:21730168). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:22330775, PubMed:21730168). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). Taurus_UMD|evm.model.AC_000185.1.38 Q2KIZ3 MCEE_BOVIN 86.000 0.96 0.285714 MCEE - Methylmalonyl-CoA epimerase, mitochondrial precursor - Bos taurus (Bovine) - MCEE gene Methylmalonyl-CoA epimerase involved in propionyl-CoA metabolism. Taurus_UMD|evm.model.AC_000185.1.39 Q5RD33 APBA2_PONAB 65.714 0.260377 0.353805 APBA2 - Amyloid-beta A4 precursor protein-binding family A member 2 - Pongo abelii (Sumatran orangutan) - APBA2 gene Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta (By similarity). Taurus_UMD|evm.model.AC_000185.1.40 Q9NRI5 DISC1_HUMAN 73.723 0.654589 0.484778 DISC1 - Disrupted in schizophrenia 1 protein - Homo sapiens (Human) - DISC1 gene Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19502360, PubMed:19303846). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (PubMed:18955030). Taurus_UMD|evm.model.AC_000185.1.41 Q9P2F8 SI1L2_HUMAN 93.202 0.998256 0.998839 SIPA1L2 - Signal-induced proliferation-associated 1-like protein 2 - Homo sapiens (Human) - SIPA1L2 gene cytoplasm, GTPase activator activity, activation of GTPase activity Taurus_UMD|evm.model.AC_000185.1.44 A3KMW7 MAP10_BOVIN 100.000 0.997809 1.0011 MAP10 - Microtubule-associated protein 10 - Bos taurus (Bovine) - MAP10 gene Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis. Taurus_UMD|evm.model.AC_000185.1.45 Q1LZ78 NTPCR_BOVIN 99.474 0.989529 1.00526 NTPCR - Cancer-related nucleoside-triphosphatase homolog - Bos taurus (Bovine) - NTPCR gene Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency (By similarity). Taurus_UMD|evm.model.AC_000185.1.46 A6NKB5 PCX2_HUMAN 83.583 0.999057 0.992045 PCNX2 - Pecanex-like protein 2 - Homo sapiens (Human) - PCNX2 gene May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H). Taurus_UMD|evm.model.AC_000185.1.47 Q5TCX8 M3K21_HUMAN 80.153 0.998092 1.01158 MAP3K21 - Mitogen-activated protein kinase kinase kinase 21 - Homo sapiens (Human) - MAP3K21 gene Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. Taurus_UMD|evm.model.AC_000185.1.48 Q10126 YSM6_CAEEL 33.962 0.468468 0.397849 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000185.1.49 Q0P5A0 KCNK1_BOVIN 100.000 0.994065 1.00298 KCNK1 - Potassium channel subfamily K member 1 - Bos taurus (Bovine) - KCNK1 gene Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (By similarity). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (By similarity). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation. The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (By similarity). Taurus_UMD|evm.model.AC_000185.1.52 Q8IY50 S35F3_HUMAN 95.012 0.995261 1.00238 SLC35F3 - Putative thiamine transporter SLC35F3 - Homo sapiens (Human) - SLC35F3 gene May be a thiamine transporter. Taurus_UMD|evm.model.AC_000185.1.53 Q2M2S5 COA6_BOVIN 100.000 0.886792 0.670886 COA6 - Cytochrome c oxidase assembly factor 6 homolog - Bos taurus (Bovine) - COA6 gene Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV. Taurus_UMD|evm.model.AC_000185.1.54 Q13395 TARB1_HUMAN 85.140 0.993236 0.547193 TARBP1 - Probable methyltransferase TARBP1 - Homo sapiens (Human) - TARBP1 gene Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. Taurus_UMD|evm.model.AC_000185.1.55 Q13395 TARB1_HUMAN 88.088 0.990654 0.198026 TARBP1 - Probable methyltransferase TARBP1 - Homo sapiens (Human) - TARBP1 gene Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. Taurus_UMD|evm.model.AC_000185.1.56 Q7Z5L9 I2BP2_HUMAN 95.248 0.950617 0.827939 IRF2BP2 - Interferon regulatory factor 2-binding protein 2 - Homo sapiens (Human) - IRF2BP2 gene Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). Taurus_UMD|evm.model.AC_000185.1.59 Q5RA31 TOM20_PONAB 100.000 0.986301 1.0069 TOMM20 - Mitochondrial import receptor subunit TOM20 homolog - Pongo abelii (Sumatran orangutan) - TOMM20 gene Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. Taurus_UMD|evm.model.AC_000185.1.60 P42696 RBM34_HUMAN 80.930 0.995338 0.997674 RBM34 - RNA-binding protein 34 - Homo sapiens (Human) - RBM34 gene chromosome, nucleolus, nucleoplasm, RNA binding Taurus_UMD|evm.model.AC_000185.1.61 Q4LE39 ARI4B_HUMAN 91.288 0.998484 1.00534 ARID4B - AT-rich interactive domain-containing protein 4B - Homo sapiens (Human) - ARID4B gene Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). Taurus_UMD|evm.model.AC_000185.1.62 P56966 GGPPS_BOVIN 100.000 0.993355 1.00333 GGPS1 - Geranylgeranyl pyrophosphate synthase - Bos taurus (Bovine) - GGPS1 gene Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Taurus_UMD|evm.model.AC_000185.1.63 Q32KS0 TBCE_BOVIN 100.000 0.807044 1.23674 TBCE - Tubulin-specific chaperone E - Bos taurus (Bovine) - TBCE gene Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network. Taurus_UMD|evm.model.AC_000185.1.64 Q8NCR0 B3GL2_HUMAN 86.800 0.993617 0.94 B3GALNT2 - UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 - Homo sapiens (Human) - B3GALNT2 gene Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Taurus_UMD|evm.model.AC_000185.1.66 Q9H5J0 ZBTB3_HUMAN 76.712 0.571429 0.219512 ZBTB3 - Zinc finger and BTB domain-containing protein 3 - Homo sapiens (Human) - ZBTB3 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000185.1.68 Q9TTK4 LYST_BOVIN 99.947 0.997372 1.00237 LYST - Lysosomal-trafficking regulator - Bos taurus (Bovine) - LYST gene May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules. Taurus_UMD|evm.model.AC_000185.1.69 Q9NBX4 RTXE_DROME 28.139 0.517084 0.48348 X-element\ORF2 - Probable RNA-directed DNA polymerase from transposon X-element - Drosophila melanogaster (Fruit fly) - X-element\ORF2 gene RNA-directed DNA polymerase activity, transposition, DNA-mediated Taurus_UMD|evm.model.AC_000185.1.70 O02751 CFDP2_BOVIN 78.261 0.85625 0.27027 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000185.1.71 P14543 NID1_HUMAN 88.809 0.843017 0.786688 NID1 - Nidogen-1 precursor - Homo sapiens (Human) - NID1 gene Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. Taurus_UMD|evm.model.AC_000185.1.72 P14543 NID1_HUMAN 75.490 0.943396 0.170008 NID1 - Nidogen-1 precursor - Homo sapiens (Human) - NID1 gene Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. Taurus_UMD|evm.model.AC_000185.1.73 P14543 NID1_HUMAN 84.091 0.988701 0.141941 NID1 - Nidogen-1 precursor - Homo sapiens (Human) - NID1 gene Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. Taurus_UMD|evm.model.AC_000185.1.74 O60478 G137B_HUMAN 91.192 0.994695 0.944862 GPR137B - Integral membrane protein GPR137B - Homo sapiens (Human) - GPR137B gene Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939). Taurus_UMD|evm.model.AC_000185.1.75 Q86YB8 ERO1B_HUMAN 96.574 0.987288 1.01071 ERO1B - ERO1-like protein beta precursor - Homo sapiens (Human) - ERO1B gene Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 ( Taurus_UMD|evm.model.AC_000185.1.76 Q710C4 SAHH_PIG 82.000 0.453704 0.25 AHCY - Adenosylhomocysteinase - Sus scrofa (Pig) - AHCY gene Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Taurus_UMD|evm.model.AC_000185.1.77 Q3MHL4 SAHH_BOVIN 38.655 0.974684 0.18287 AHCY - Adenosylhomocysteinase - Bos taurus (Bovine) - AHCY gene Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Taurus_UMD|evm.model.AC_000185.1.79 Q8WWZ3 EDAD_HUMAN 84.615 0.941748 0.95814 EDARADD - Ectodysplasin-A receptor-associated adapter protein - Homo sapiens (Human) - EDARADD gene Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B. Taurus_UMD|evm.model.AC_000185.1.81 O00214 LEG8_HUMAN 74.790 0.994413 1.12934 LGALS8 - Galectin-8 - Homo sapiens (Human) - LGALS8 gene Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902). Taurus_UMD|evm.model.AC_000185.1.82 Q9GM44 HEAT1_MACFA 89.353 0.445637 2.23695 HEATR1 - HEAT repeat-containing protein 1 - Macaca fascicularis (Crab-eating macaque) - HEATR1 gene Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Taurus_UMD|evm.model.AC_000185.1.83 Q3ZC55 ACTN2_BOVIN 99.883 0.989559 0.964206 ACTN2 - Alpha-actinin-2 - Bos taurus (Bovine) - ACTN2 gene F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). Taurus_UMD|evm.model.AC_000185.1.84 Q4JIJ3 METH_BOVIN 99.605 0.99842 1.00079 MTR - Methionine synthase - Bos taurus (Bovine) - MTR gene Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Taurus_UMD|evm.model.AC_000185.1.85 Q92736 RYR2_HUMAN 97.725 0.998589 0.998591 RYR2 - Ryanodine receptor 2 - Homo sapiens (Human) - RYR2 gene Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. Taurus_UMD|evm.model.AC_000185.1.86 Q9BH11 ZP4_BOVIN 100.000 0.95186 0.855805 ZP4 - Zona pellucida sperm-binding protein 4 precursor - Bos taurus (Bovine) - ZP4 gene Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor. Taurus_UMD|evm.model.AC_000185.1.87 Q13398 ZN211_HUMAN 48.485 0.866667 0.132979 ZNF211 - Zinc finger protein 211 - Homo sapiens (Human) - ZNF211 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000185.1.89 P62958 HINT1_BOVIN 92.754 0.971429 0.555556 HINT1 - Histidine triad nucleotide-binding protein 1 - Bos taurus (Bovine) - HINT1 gene Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Taurus_UMD|evm.model.AC_000185.1.91 P41984 ACM3_BOVIN 100.000 0.9866 1.01186 CHRM3 - Muscarinic acetylcholine receptor M3 - Bos taurus (Bovine) - CHRM3 gene The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Taurus_UMD|evm.model.AC_000185.1.92 Q12967 GNDS_HUMAN 59.259 0.296296 0.295405 RALGDS - Ral guanine nucleotide dissociation stimulator - Homo sapiens (Human) - RALGDS gene Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. Taurus_UMD|evm.model.AC_000185.1.93 Q06732 ZN33B_HUMAN 80.745 0.996073 0.982005 ZNF33B - Zinc finger protein 33B - Homo sapiens (Human) - ZNF33B gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000185.1.94 P17032 ZN37A_HUMAN 69.799 0.772201 0.923351 ZNF37A - Zinc finger protein 37A - Homo sapiens (Human) - ZNF37A gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000185.1.95 Q03385 GNDS_MOUSE 59.375 0.328125 0.525822 Ralgds - Ral guanine nucleotide dissociation stimulator - Mus musculus (Mouse) - Ralgds gene Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. Taurus_UMD|evm.model.AC_000185.1.96 P17030 ZNF25_HUMAN 83.444 0.993363 0.991228 ZNF25 - Zinc finger protein 25 - Homo sapiens (Human) - ZNF25 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000185.1.97 Q8NDW4 ZN248_HUMAN 82.902 0.996546 1 ZNF248 - Zinc finger protein 248 - Homo sapiens (Human) - ZNF248 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000185.1.98 Q5VTM2 AGAP9_HUMAN 96.629 0.0683761 1.83073 AGAP9 - Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9 - Homo sapiens (Human) - AGAP9 gene Putative GTPase-activating protein. Taurus_UMD|evm.model.AC_000185.1.99 Q6ZN17 LN28B_HUMAN 74.576 0.552381 0.42 LIN28B - Protein lin-28 homolog B - Homo sapiens (Human) - LIN28B gene Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. Taurus_UMD|evm.model.AC_000185.1.100 P07949 RET_HUMAN 85.920 0.994208 0.929982 RET - Proto-oncogene tyrosine-protein kinase receptor Ret precursor - Homo sapiens (Human) - RET gene Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration. Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways (PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL (PubMed:28846099). Taurus_UMD|evm.model.AC_000185.1.101 Q8N6G5 CGAT2_HUMAN 96.310 0.939236 1.06273 CSGALNACT2 - Chondroitin sulfate N-acetylgalactosaminyltransferase 2 - Homo sapiens (Human) - CSGALNACT2 gene Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Taurus_UMD|evm.model.AC_000185.1.102 Q8N9B8 RGF1A_HUMAN 95.426 0.995842 1 RASGEF1A - Ras-GEF domain-containing family member 1A - Homo sapiens (Human) - RASGEF1A gene Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration. Taurus_UMD|evm.model.AC_000185.1.103 Q63113 FXYD4_RAT 69.048 0.864583 1.10345 Fxyd4 - FXYD domain-containing ion transport regulator 4 precursor - Rattus norvegicus (Rat) - Fxyd4 gene Induces a potassium channel when expressed in Xenopus oocytes. Taurus_UMD|evm.model.AC_000185.1.104 Q5E9J1 HNRPF_BOVIN 100.000 0.995181 1.00242 HNRNPF - Heterogeneous nuclear ribonucleoprotein F - Bos taurus (Bovine) - HNRNPF gene Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity). Taurus_UMD|evm.model.AC_000185.1.105 Q8WXA8 5HT3C_HUMAN 44.828 0.391304 0.61745 HTR3C - 5-hydroxytryptamine receptor 3C precursor - Homo sapiens (Human) - HTR3C gene This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Taurus_UMD|evm.model.AC_000185.1.106 Q9H694 BICC1_HUMAN 96.420 0.997611 0.859343 BICC1 - Protein bicaudal C homolog 1 - Homo sapiens (Human) - BICC1 gene Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. Taurus_UMD|evm.model.AC_000185.1.107 Q10126 YSM6_CAEEL 30.000 0.661972 0.763441 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000185.1.108 Q32L96 PHIPL_BOVIN 100.000 0.64433 1.54787 PHYHIPL - Phytanoyl-CoA hydroxylase interacting protein-like - Bos taurus (Bovine) - PHYHIPL gene May play a role in the development of the central system. Taurus_UMD|evm.model.AC_000185.1.109 Q8NE31 FA13C_HUMAN 87.350 0.996558 0.993162 FAM13C - Protein FAM13C - Homo sapiens (Human) - FAM13C gene Taurus_UMD|evm.model.AC_000185.1.112 Q5R5M4 MOT9_PONAB 89.730 0.847926 0.852652 SLC16A9 - Monocarboxylate transporter 9 - Pongo abelii (Sumatran orangutan) - SLC16A9 gene Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. Taurus_UMD|evm.model.AC_000185.1.113 Q16204 CCDC6_HUMAN 98.928 0.900726 0.871308 CCDC6 - Coiled-coil domain-containing protein 6 - Homo sapiens (Human) - CCDC6 gene cytosol, identical protein binding, structural constituent of cytoskeleton Taurus_UMD|evm.model.AC_000185.1.115 Q12955 ANK3_HUMAN 97.521 0.0294913 0.929632 ANK3 - Ankyrin-3 - Homo sapiens (Human) - ANK3 gene In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Taurus_UMD|evm.model.AC_000185.1.117 P48734 CDK1_BOVIN 100.000 0.993289 1.00337 CDK1 - Cyclin-dependent kinase 1 - Bos taurus (Bovine) - CDK1 gene Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration. CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis. Regulates the amplitude of the cyclic expression of the core clock gene ARNTL/BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (By similarity). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (By similarity). Taurus_UMD|evm.model.AC_000185.1.118 O46414 FRIH_BOVIN 82.963 0.683673 1.08287 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000185.1.119 O94844 RHBT1_HUMAN 93.696 0.997139 1.00431 RHOBTB1 - Rho-related BTB domain-containing protein 1 - Homo sapiens (Human) - RHOBTB1 gene cell cortex, cell projection, cytoplasmic vesicle, cytoskeleton, endosome membrane, intracellular membrane-bounded organelle, plasma membrane, GTP binding, GTPase activity, protein kinase binding Taurus_UMD|evm.model.AC_000185.1.122 Q6ZUK4 TMM26_HUMAN 72.011 0.993569 0.845109 TMEM26 - Transmembrane protein 26 - Homo sapiens (Human) - TMEM26 gene Taurus_UMD|evm.model.AC_000185.1.123 Q8IVU9 CBCO1_HUMAN 83.173 0.678808 1.45192 CABCOCO1 - Ciliary-associated calcium-binding coiled-coil protein 1 - Homo sapiens (Human) - CABCOCO1 gene Calcium-binding protein. May be involved in the control of sperm flagellar movement. Taurus_UMD|evm.model.AC_000185.1.124 Q8BM75 ARI5B_MOUSE 100.000 0.837209 0.108586 Arid5b - AT-rich interactive domain-containing protein 5B - Mus musculus (Mouse) - Arid5b gene Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-337, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver (By similarity). Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Taurus_UMD|evm.model.AC_000185.1.125 E1BLP6 ARI5B_BOVIN 99.498 0.934272 0.544757 ARID5B - AT-rich interactive domain-containing protein 5B - Bos taurus (Bovine) - ARID5B gene Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-340, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation (By similarity). Taurus_UMD|evm.model.AC_000185.1.126 E1BLP6 ARI5B_BOVIN 100.000 0.993921 0.280477 ARID5B - AT-rich interactive domain-containing protein 5B - Bos taurus (Bovine) - ARID5B gene Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-340, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation (By similarity). Taurus_UMD|evm.model.AC_000185.1.127 Q8IZC4 RTKN2_HUMAN 82.102 0.996661 0.98358 RTKN2 - Rhotekin-2 - Homo sapiens (Human) - RTKN2 gene May play an important role in lymphopoiesis. Taurus_UMD|evm.model.AC_000185.1.129 Q5R9L2 ZN365_PONAB 81.081 0.994624 0.914005 ZNF365 - Protein ZNF365 - Pongo abelii (Sumatran orangutan) - ZNF365 gene Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (By similarity). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery. Contributes to genomic stability by preventing telomere dysfunction (By similarity). Taurus_UMD|evm.model.AC_000185.1.130 Q96SZ5 AEDO_HUMAN 90.741 0.99262 1.0037 ADO - 2-aminoethanethiol dioxygenase - Homo sapiens (Human) - ADO gene cytosol, sulfur amino acid catabolic process Taurus_UMD|evm.model.AC_000185.1.131 A1XSY8 EGR2_PIG 95.975 0.995772 1.00425 EGR2 - E3 SUMO-protein ligase EGR2 - Sus scrofa (Pig) - EGR2 gene Sequence-specific DNA-binding transcription factor (By similarity). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity). Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity). Taurus_UMD|evm.model.AC_000185.1.132 Q5R4C9 NRBF2_PONAB 92.473 0.674757 1.43554 NRBF2 - Nuclear receptor-binding factor 2 - Pongo abelii (Sumatran orangutan) - NRBF2 gene May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) (By similarity). Taurus_UMD|evm.model.AC_000185.1.133 Q15652 JHD2C_HUMAN 91.627 0.999211 0.998425 JMJD1C - Probable JmjC domain-containing histone demethylation protein 2C - Homo sapiens (Human) - JMJD1C gene Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). Taurus_UMD|evm.model.AC_000185.1.134 Q6NUK4 REEP3_HUMAN 95.492 0.931034 1.02353 REEP3 - Receptor expression-enhancing protein 3 - Homo sapiens (Human) - REEP3 gene Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes. Taurus_UMD|evm.model.AC_000185.1.135 Q920A7 AFG31_MOUSE 72.642 0.660377 0.201521 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Taurus_UMD|evm.model.AC_000185.1.136 Q3SYR7 RL9_BOVIN 64.602 0.97561 0.427083 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000185.1.138 P84092 AP2M1_RAT 98.366 0.92145 0.76092 Ap2m1 - AP-2 complex subunit mu - Rattus norvegicus (Rat) - Ap2m1 gene Component of the adaptor protein complex 2 (AP-2) (PubMed:14745134, PubMed:15473838). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways (PubMed:14745134, PubMed:15473838). Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation (PubMed:14745134, PubMed:15473838). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome (PubMed:14745134, PubMed:15473838). The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components (PubMed:14745134, PubMed:15473838). Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation (PubMed:14745134, PubMed:15473838). AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis (PubMed:14745134, PubMed:15473838). AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface (By similarity). AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules (PubMed:15985462). AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway (By similarity). During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 mu (AP2M1) subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs (PubMed:15985462). The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Thr-156 in membrane-associated AP-2 (PubMed:15985462, PubMed:11516654). The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role in endocytosis of frizzled family members upon Wnt signaling (PubMed:20947020). Taurus_UMD|evm.model.AC_000185.1.139 Q9UI47 CTNA3_HUMAN 95.405 0.963446 0.427933 CTNNA3 - Catenin alpha-3 - Homo sapiens (Human) - CTNNA3 gene May be involved in formation of stretch-resistant cell-cell adhesion complexes. Taurus_UMD|evm.model.AC_000185.1.140 Q9BGP6 LRRT3_MACFA 99.574 0.995754 0.810671 LRRTM3 - Leucine-rich repeat transmembrane neuronal protein 3 precursor - Macaca fascicularis (Crab-eating macaque) - LRRTM3 gene May play a role in the development and maintenance of the vertebrate nervous system. Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). Taurus_UMD|evm.model.AC_000185.1.141 Q9BGP6 LRRT3_MACFA 94.203 0.829268 0.141136 LRRTM3 - Leucine-rich repeat transmembrane neuronal protein 3 precursor - Macaca fascicularis (Crab-eating macaque) - LRRTM3 gene May play a role in the development and maintenance of the vertebrate nervous system. Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). Taurus_UMD|evm.model.AC_000185.1.142 Q92734 TFG_HUMAN 92.917 0.967611 0.6175 TFG - Protein TFG - Homo sapiens (Human) - TFG gene Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). Taurus_UMD|evm.model.AC_000185.1.143 Q9UI47 CTNA3_HUMAN 90.191 0.925258 0.43352 CTNNA3 - Catenin alpha-3 - Homo sapiens (Human) - CTNNA3 gene May be involved in formation of stretch-resistant cell-cell adhesion complexes. Taurus_UMD|evm.model.AC_000185.1.146 Q9N287 DJC12_BOVIN 100.000 0.98995 1.00505 DNAJC12 - DnaJ homolog subfamily C member 12 - Bos taurus (Bovine) - DNAJC12 gene cytoplasm Taurus_UMD|evm.model.AC_000185.1.147 A0A0G2JZ79 SIR1_RAT 88.869 0.756463 1.32432 Sirt1 - NAD-dependent protein deacetylase sirtuin-1 - Rattus norvegicus (Rat) - Sirt1 gene NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction. Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Deacetylates 'Lys-266' of SUV39H1, leading to its activation. Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1. Deacetylates H2A and 'Lys-26' of H1-4. Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression. Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting. Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1. Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2. This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response. Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence. Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I. Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability. Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation. Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis. Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing. Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha. Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1. Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver. Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation. Involved in HES1- and HEY2-mediated transcriptional repression. In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62'. Deacetylates MEF2D. Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3. Represses HNF1A-mediated transcription. Required for the repression of ESRRG by CREBZF. Deacetylates NR1H3 AND NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteosomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed. Involved in lipid metabolism. Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2. Deacetylates p300/EP300 and PRMT1. Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation. Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis. Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression. Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2. Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN. Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage. Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1. Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8. Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation. Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear. In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability. Deacetylates MECOM/EVI1. Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization. During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including ARNTL/BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling. Deacetylates ARNTL/BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator. Deacetylates PER2, facilitating its ubiquitination and degradation by the proteosome. Protects cardiomyocytes against palmitate-induced apoptosis. Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity. Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis. Involved in the CCAR2-mediated regulation of PCK1 and NR1D1. Deacetylates CTNB1 at 'Lys-49'. In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling. In addition to protein deacetylase activity, also acts as protein-lysine deacylase: acts as a protein depropionylase by mediating depropionylation of Osterix (SP7). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity. Involved in the regulation of centrosome duplication. Deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (By similarity). Taurus_UMD|evm.model.AC_000185.1.148 Q5GLZ8 HERC4_HUMAN 97.540 0.99811 1.00095 HERC4 - Probable E3 ubiquitin-protein ligase HERC4 - Homo sapiens (Human) - HERC4 gene Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates. Taurus_UMD|evm.model.AC_000185.1.149 Q86TC9 MYPN_HUMAN 91.597 0.998486 1.00076 MYPN - Myopalladin - Homo sapiens (Human) - MYPN gene Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. Taurus_UMD|evm.model.AC_000185.1.150 Q8N100 ATOH7_HUMAN 91.447 0.986928 1.00658 ATOH7 - Protein atonal homolog 7 - Homo sapiens (Human) - ATOH7 gene Transcription factor that positively regulates the determination of retinal ganglion cell fate and formation of the optic nerve and retino-hypothalamic tract (By similarity). Required for retinal circadian rhythm photoentrainment (By similarity). Taurus_UMD|evm.model.AC_000185.1.151 Q2HJF4 PBLD_BOVIN 100.000 0.99308 1.00347 PBLD - Phenazine biosynthesis-like domain-containing protein - Bos taurus (Bovine) - PBLD gene cytoplasm, isomerase activity Taurus_UMD|evm.model.AC_000185.1.152 P31942 HNRH3_HUMAN 100.000 0.819477 1.21676 HNRNPH3 - Heterogeneous nuclear ribonucleoprotein H3 - Homo sapiens (Human) - HNRNPH3 gene Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction. Taurus_UMD|evm.model.AC_000185.1.153 E1BMP7 DNA2_BOVIN 100.000 0.648969 1.50895 DNA2 - DNA replication ATP-dependent helicase/nuclease DNA2 - Bos taurus (Bovine) - DNA2 gene Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function (By similarity). Taurus_UMD|evm.model.AC_000185.1.154 Q01888 GDC_BOVIN 99.697 0.993958 1.00303 SLC25A16 - Graves disease carrier protein - Bos taurus (Bovine) - SLC25A16 gene Required for the accumulation of coenzyme A in the mitochondrial matrix. Taurus_UMD|evm.model.AC_000185.1.155 Q9HCP6 HHATL_HUMAN 52.381 0.731844 0.355159 HHATL - Protein-cysteine N-palmitoyltransferase HHAT-like protein - Homo sapiens (Human) - HHATL gene Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN. Taurus_UMD|evm.model.AC_000185.1.156 Q8NFU7 TET1_HUMAN 81.955 0.258537 0.959738 TET1 - Methylcytosine dioxygenase TET1 - Homo sapiens (Human) - TET1 gene Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Plays an important role in the tumorigenicity of glioblastoma cells. TET1-mediated production of 5hmC acts as a recruitment signal for the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). Taurus_UMD|evm.model.AC_000185.1.157 Q8IX12 CCAR1_HUMAN 98.915 0.993521 0.402609 CCAR1 - Cell division cycle and apoptosis regulator protein 1 - Homo sapiens (Human) - CCAR1 gene Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). Taurus_UMD|evm.model.AC_000185.1.158 Q8IX12 CCAR1_HUMAN 88.290 0.96627 0.438261 CCAR1 - Cell division cycle and apoptosis regulator protein 1 - Homo sapiens (Human) - CCAR1 gene Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). Taurus_UMD|evm.model.AC_000185.1.159 Q6ZVD7 STOX1_HUMAN 74.545 0.99797 0.995956 STOX1 - Storkhead-box protein 1 - Homo sapiens (Human) - STOX1 gene Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity). Taurus_UMD|evm.model.AC_000185.1.160 Q9BQ39 DDX50_HUMAN 97.422 0.99729 1.00136 DDX50 - ATP-dependent RNA helicase DDX50 - Homo sapiens (Human) - DDX50 gene membrane, nucleolus, plasma membrane, RNA binding, RNA helicase activity Taurus_UMD|evm.model.AC_000185.1.161 Q9NR30 DDX21_HUMAN 88.917 0.997452 1.00255 DDX21 - Nucleolar RNA helicase 2 - Homo sapiens (Human) - DDX21 gene RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1 (By similarity). Taurus_UMD|evm.model.AC_000185.1.162 Q3SYS9 KBP_BOVIN 100.000 0.996785 1.00161 KIFBP - KIF-binding protein - Bos taurus (Bovine) - KIFBP gene Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. Taurus_UMD|evm.model.AC_000185.1.163 P10124 SRGN_HUMAN 58.088 0.732955 1.11392 SRGN - Serglycin precursor - Homo sapiens (Human) - SRGN gene Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization. Taurus_UMD|evm.model.AC_000185.1.164 Q0VD53 VP26A_BOVIN 100.000 0.993902 1.00306 VPS26A - Vacuolar protein sorting-associated protein 26A - Bos taurus (Bovine) - VPS26A gene Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC complex seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required for retrograde transport of lysosomal enzyme receptor IGF2R. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for the endosomal localization of WASHC2 (indicative for the WASH complex). Required for the endosomal localization of TBC1D5. Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP. Involved in retromer-independent lysosomal sorting of F2R. Involved in recycling of ADRB2. Acts redundantly with VSP26B in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1. Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). Taurus_UMD|evm.model.AC_000185.1.165 Q8IYB8 SUV3_HUMAN 90.597 0.997462 1.00254 SUPV3L1 - ATP-dependent RNA helicase SUPV3L1, mitochondrial precursor - Homo sapiens (Human) - SUPV3L1 gene Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. Taurus_UMD|evm.model.AC_000185.1.166 Q2TB90 HKDC1_HUMAN 93.021 0.997821 1.00109 HKDC1 - Hexokinase HKDC1 - Homo sapiens (Human) - HKDC1 gene Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases (PubMed:30517626). Has low glucose phosphorylating activity compared to other hexokinases (PubMed:30517626). Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (By similarity). Taurus_UMD|evm.model.AC_000185.1.167 P19367 HXK1_HUMAN 95.095 0.9718 1.00545 HK1 - Hexokinase-1 - Homo sapiens (Human) - HK1 gene Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). Taurus_UMD|evm.model.AC_000185.1.168 P05363 NK2R_BOVIN 96.970 0.994962 1.03385 TACR2 - Substance-K receptor - Bos taurus (Bovine) - TACR2 gene This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. Taurus_UMD|evm.model.AC_000185.1.169 Q1JQA4 TSN15_BOVIN 100.000 0.99322 1.0034 TSPAN15 - Tetraspanin-15 - Bos taurus (Bovine) - TSPAN15 gene Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Promotes ADAM10-mediated cleavage of CDH2 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Taurus_UMD|evm.model.AC_000185.1.170 Q9Y4Z2 NGN3_HUMAN 82.326 0.990741 1.00935 NEUROG3 - Neurogenin-3 - Homo sapiens (Human) - NEUROG3 gene Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity). Taurus_UMD|evm.model.AC_000185.1.172 Q96D05 F241B_HUMAN 94.215 0.533632 1.84298 FAM241B - Protein FAM241B - Homo sapiens (Human) - FAM241B gene May play a role in lysosome homeostasis. Taurus_UMD|evm.model.AC_000185.1.173 Q9R1N9 CODA1_MOUSE 81.735 0.997167 0.94008 Col13a1 - Collagen alpha-1(XIII) chain - Mus musculus (Mouse) - Col13a1 gene Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625). Taurus_UMD|evm.model.AC_000185.1.174 Q9P0M6 H2AW_HUMAN 99.731 0.994638 1.00269 MACROH2A2 - Core histone macro-H2A.2 - Homo sapiens (Human) - MACROH2A2 gene Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. Taurus_UMD|evm.model.AC_000185.1.175 A5PJM4 FSP1_BOVIN 100.000 0.994652 1.00268 AIFM2 - Ferroptosis suppressor protein 1 - Bos taurus (Bovine) - AIFM2 gene A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death. Capable of DNA binding in a non-sequence specific way. Taurus_UMD|evm.model.AC_000185.1.176 Q2T9J0 TYSD1_HUMAN 81.777 0.863905 0.89576 TYSND1 - Peroxisomal leader peptide-processing protease - Homo sapiens (Human) - TYSND1 gene Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids. Taurus_UMD|evm.model.AC_000185.1.177 Q52NJ3 SAR1A_PIG 100.000 0.98995 1.00505 SAR1A - GTP-binding protein SAR1a - Sus scrofa (Pig) - SAR1A gene Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES) (By similarity). Taurus_UMD|evm.model.AC_000185.1.178 P37980 IPYR_BOVIN 93.772 0.992647 0.941176 PPA1 - Inorganic pyrophosphatase - Bos taurus (Bovine) - PPA1 gene cytosol, inorganic diphosphatase activity, magnesium ion binding, phosphate-containing compound metabolic process Taurus_UMD|evm.model.AC_000185.1.179 Q9GZQ6 NPFF1_HUMAN 89.815 0.970721 1.03256 NPFFR1 - Neuropeptide FF receptor 1 - Homo sapiens (Human) - NPFFR1 gene Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000185.1.180 Q8TCA0 LRC20_HUMAN 91.304 0.989189 1.00543 LRRC20 - Leucine-rich repeat-containing protein 20 - Homo sapiens (Human) - LRRC20 gene Taurus_UMD|evm.model.AC_000185.1.181 Q13542 4EBP2_HUMAN 99.167 0.983471 1.00833 EIF4EBP2 - Eukaryotic translation initiation factor 4E-binding protein 2 - Homo sapiens (Human) - EIF4EBP2 gene Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). Taurus_UMD|evm.model.AC_000185.1.182 Q96S42 NODAL_HUMAN 85.057 0.994236 1 NODAL - Nodal homolog precursor - Homo sapiens (Human) - NODAL gene Essential for mesoderm formation and axial patterning during embryonic development. Taurus_UMD|evm.model.AC_000185.1.183 Q9ULE6 PALD_HUMAN 85.601 0.954315 0.920561 PALD1 - Paladin - Homo sapiens (Human) - PALD1 gene cytoplasm, cytosol, protein tyrosine phosphatase activity Taurus_UMD|evm.model.AC_000185.1.184 Q9ULE6 PALD_HUMAN 78.431 0.148968 0.792056 PALD1 - Paladin - Homo sapiens (Human) - PALD1 gene cytoplasm, cytosol, protein tyrosine phosphatase activity Taurus_UMD|evm.model.AC_000185.1.185 Q8WXS8 ATS14_HUMAN 83.086 0.779783 0.905969 ADAMTS14 - A disintegrin and metalloproteinase with thrombospondin motifs 14 precursor - Homo sapiens (Human) - ADAMTS14 gene Has aminoprocollagen type I processing activity in the absence of ADAMTS2 (PubMed:11741898). Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity (PubMed:11741898). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form (PubMed:31152061). Taurus_UMD|evm.model.AC_000185.1.186 Q32KL8 TBATA_BOVIN 95.129 0.994286 1.05105 TBATA - Protein TBATA - Bos taurus (Bovine) - TBATA gene May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function. Taurus_UMD|evm.model.AC_000185.1.187 O95470 SGPL1_HUMAN 91.021 0.996485 1.00176 SGPL1 - Sphingosine-1-phosphate lyase 1 - Homo sapiens (Human) - SGPL1 gene Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (PubMed:11018465, PubMed:14570870, PubMed:24809814, PubMed:28165339). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity). Taurus_UMD|evm.model.AC_000185.1.188 Q3ZBD3 PHS_BOVIN 100.000 0.980952 1.00962 PCBD1 - Pterin-4-alpha-carbinolamine dehydratase - Bos taurus (Bovine) - PCBD1 gene Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). Taurus_UMD|evm.model.AC_000185.1.189 Q8IZJ1 UNC5B_HUMAN 95.238 0.997886 1.00106 UNC5B - Netrin receptor UNC5B precursor - Homo sapiens (Human) - UNC5B gene Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity). Taurus_UMD|evm.model.AC_000185.1.190 A1A4N1 S29A3_BOVIN 98.039 0.948598 0.451477 SLC29A3 - Equilibrative nucleoside transporter 3 - Bos taurus (Bovine) - SLC29A3 gene Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine (By similarity). Taurus_UMD|evm.model.AC_000185.1.192 A1A4N1 S29A3_BOVIN 100.000 0.992565 0.567511 SLC29A3 - Equilibrative nucleoside transporter 3 - Bos taurus (Bovine) - SLC29A3 gene Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine (By similarity). Taurus_UMD|evm.model.AC_000185.1.193 Q99PF4 CAD23_MOUSE 98.958 0.248691 0.113894 Cdh23 - Cadherin-23 precursor - Mus musculus (Mouse) - Cdh23 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Taurus_UMD|evm.model.AC_000185.1.195 Q8TEF2 CJ105_HUMAN 77.444 0.983871 0.932331 C10orf105 - Uncharacterized protein C10orf105 - Homo sapiens (Human) - C10orf105 gene Taurus_UMD|evm.model.AC_000185.1.196 Q9H251 CAD23_HUMAN 94.929 0.842196 0.173822 CDH23 - Cadherin-23 precursor - Homo sapiens (Human) - CDH23 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Taurus_UMD|evm.model.AC_000185.1.197 Q9H7M9 VISTA_HUMAN 82.051 0.99359 1.00322 VSIR - V-type immunoglobulin domain-containing suppressor of T-cell activation precursor - Homo sapiens (Human) - VSIR gene Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). Taurus_UMD|evm.model.AC_000185.1.198 Q9H251 CAD23_HUMAN 93.445 0.998277 0.519082 CDH23 - Cadherin-23 precursor - Homo sapiens (Human) - CDH23 gene Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Taurus_UMD|evm.model.AC_000185.1.199 P26779 SAP_BOVIN 99.810 0.996198 1.0019 PSAP - Prosaposin precursor - Bos taurus (Bovine) - PSAP gene Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Taurus_UMD|evm.model.AC_000185.1.201 Q7LGC8 CHST3_HUMAN 88.174 0.995833 1.00209 CHST3 - Carbohydrate sulfotransferase 3 - Homo sapiens (Human) - CHST3 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen. Taurus_UMD|evm.model.AC_000185.1.203 Q92563 TICN2_HUMAN 96.226 0.995261 0.995283 SPOCK2 - Testican-2 precursor - Homo sapiens (Human) - SPOCK2 gene May participate in diverse steps of neurogenesis. Binds calcium. Taurus_UMD|evm.model.AC_000185.1.204 Q9D8Z1 ASCC1_MOUSE 84.594 0.994413 1.00562 Ascc1 - Activating signal cointegrator 1 complex subunit 1 - Mus musculus (Mouse) - Ascc1 gene Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. Taurus_UMD|evm.model.AC_000185.1.205 Q58DR0 APC16_BOVIN 100.000 0.981982 1.00909 ANAPC16 - Anaphase-promoting complex subunit 16 - Bos taurus (Bovine) - ANAPC16 gene Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). Taurus_UMD|evm.model.AC_000185.1.206 Q08E62 DDIT4_BOVIN 100.000 0.991304 1.00437 DDIT4 - DNA damage-inducible transcript 4 protein - Bos taurus (Bovine) - DDIT4 gene Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes. Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Taurus_UMD|evm.model.AC_000185.1.207 Q58DR2 DJB12_BOVIN 97.838 0.965608 1.02162 DNAJB12 - DnaJ homolog subfamily B member 12 - Bos taurus (Bovine) - DNAJB12 gene Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear. Taurus_UMD|evm.model.AC_000185.1.208 Q0IIL1 MICU1_BOVIN 98.354 0.995893 1.01883 MICU1 - Calcium uptake protein 1, mitochondrial precursor - Bos taurus (Bovine) - MICU1 gene Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Taurus_UMD|evm.model.AC_000185.1.209 Q8NE86 MCU_HUMAN 98.575 0.994318 1.00285 MCU - Calcium uniporter protein, mitochondrial precursor - Homo sapiens (Human) - MCU gene Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (PubMed:24560927, PubMed:26903221). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276). participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Involved in antigen processing and presentation (By similarity). Taurus_UMD|evm.model.AC_000185.1.210 Q29RU2 OIT3_BOVIN 99.451 0.430952 0.767824 OIT3 - Oncoprotein-induced transcript 3 protein precursor - Bos taurus (Bovine) - OIT3 gene May be involved in hepatocellular function and development. Taurus_UMD|evm.model.AC_000185.1.211 Q9BX93 PG12B_HUMAN 92.308 0.989796 1.00513 PLA2G12B - Group XIIB secretory phospholipase A2-like protein precursor - Homo sapiens (Human) - PLA2G12B gene Not known; does not seem to have catalytic activity. Taurus_UMD|evm.model.AC_000185.1.212 Q1RMU3 P4HA1_BOVIN 98.127 0.996262 1.00187 P4HA1 - Prolyl 4-hydroxylase subunit alpha-1 precursor - Bos taurus (Bovine) - P4HA1 gene Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Taurus_UMD|evm.model.AC_000185.1.213 Q86X67 NUD13_HUMAN 84.659 0.994334 1.00284 NUDT13 - NAD(P)H pyrophosphatase NUDT13, mitochondrial precursor - Homo sapiens (Human) - NUDT13 gene NAD(P)H pyrophosphatase that hydrolyzes NADH into NMNH and AMP, and NADPH into NMNH and 2',5'-ADP. Has a marked preference for the reduced pyridine nucleotides. Does not show activity toward NAD-capped RNAs; the NAD-cap is an atypical cap present at the 5'-end of some RNAs. Taurus_UMD|evm.model.AC_000185.1.214 O95905 ECD_HUMAN 85.404 0.99689 0.998447 ECD - Protein ecdysoneless homolog - Homo sapiens (Human) - ECD gene Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). Taurus_UMD|evm.model.AC_000185.1.215 A0JNF3 F149B_BOVIN 100.000 0.835897 1.19145 FAM149B1 - Primary cilium assembly protein FAM149B1 - Bos taurus (Bovine) - FAM149B1 gene Involved in the localization of proteins to the cilium and cilium assembly. Indirectly regulates the signaling functions of the cilium, being required for normal SHH/smoothened signaling and proper development. Taurus_UMD|evm.model.AC_000185.1.216 Q8WXX5 DNJC9_HUMAN 94.650 0.927203 1.00385 DNAJC9 - DnaJ homolog subfamily C member 9 - Homo sapiens (Human) - DNAJC9 gene May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8. Taurus_UMD|evm.model.AC_000185.1.217 P82915 RT16_BOVIN 100.000 0.985294 1.00741 MRPS16 - 28S ribosomal protein S16, mitochondrial precursor - Bos taurus (Bovine) - MRPS16 gene mitochondrial inner membrane, mitochondrial small ribosomal subunit, small ribosomal subunit, structural constituent of ribosome, mitochondrial translation Taurus_UMD|evm.model.AC_000185.1.218 P20072 ANXA7_BOVIN 99.784 0.278986 3.57667 ANXA7 - Annexin A7 - Bos taurus (Bovine) - ANXA7 gene Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Taurus_UMD|evm.model.AC_000185.1.219 Q4VC12 MSS51_HUMAN 84.902 0.989154 1.00217 MSS51 - Putative protein MSS51 homolog, mitochondrial - Homo sapiens (Human) - MSS51 gene Taurus_UMD|evm.model.AC_000185.1.220 P16298 PP2BB_HUMAN 99.091 0.981982 0.211832 PPP3CB - Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform - Homo sapiens (Human) - PPP3CB gene Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:26794871). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). Taurus_UMD|evm.model.AC_000185.1.221 P20651 PP2BB_RAT 100.000 0.964088 0.689524 Ppp3cb - Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform - Rattus norvegicus (Rat) - Ppp3cb gene Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Taurus_UMD|evm.model.AC_000185.1.222 Q8BL06 UBP54_MOUSE 96.073 0.225444 1.06423 Usp54 - Inactive ubiquitin carboxyl-terminal hydrolase 54 - Mus musculus (Mouse) - Usp54 gene Has no peptidase activity. Taurus_UMD|evm.model.AC_000185.1.223 Q8SQ24 MYOZ1_BOVIN 90.909 0.261497 3.73401 MYOZ1 - Myozenin-1 - Bos taurus (Bovine) - MYOZ1 gene Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity). Taurus_UMD|evm.model.AC_000185.1.224 P53992 SC24C_HUMAN 94.343 0.998174 1.00091 SEC24C - Protein transport protein Sec24C - Homo sapiens (Human) - SEC24C gene Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). Taurus_UMD|evm.model.AC_000185.1.225 Q495W5 FUT11_HUMAN 91.121 0.955466 1.00407 FUT11 - Alpha-(1,3)-fucosyltransferase 11 - Homo sapiens (Human) - FUT11 gene Probable fucosyltransferase. Taurus_UMD|evm.model.AC_000185.1.226 Q96BP2 CHCH1_HUMAN 85.593 0.983193 1.00847 CHCHD1 - Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 - Homo sapiens (Human) - CHCHD1 gene cytosol, fibrillar center, mitochondrial inner membrane, mitochondrion, nucleoplasm, RNA binding, mitochondrial translational elongation, mitochondrial translational termination Taurus_UMD|evm.model.AC_000185.1.227 A7E305 ZSWM8_BOVIN 100.000 0.567612 1.29795 ZSWIM8 - Zinc finger SWIM domain-containing protein 8 - Bos taurus (Bovine) - ZSWIM8 gene Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation. Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target. May also acts as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation. Taurus_UMD|evm.model.AC_000185.1.228 O97583 NDST2_BOVIN 97.851 0.997738 1 NDST2 - Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 - Bos taurus (Bovine) - NDST2 gene Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Taurus_UMD|evm.model.AC_000185.1.229 Q13555 KCC2G_HUMAN 95.604 0.917526 1.04301 CAMK2G - Calcium/calmodulin-dependent protein kinase type II subunit gamma - Homo sapiens (Human) - CAMK2G gene Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. Taurus_UMD|evm.model.AC_000185.1.230 Q05589 UROK_BOVIN 100.000 0.995392 1.00231 PLAU - Urokinase-type plasminogen activator precursor - Bos taurus (Bovine) - PLAU gene Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Taurus_UMD|evm.model.AC_000185.1.231 Q5R9E5 FA32A_PONAB 81.416 0.956897 1.03571 FAM32A - Protein FAM32A - Pongo abelii (Sumatran orangutan) - FAM32A gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Taurus_UMD|evm.model.AC_000185.1.232 B0JZ89 FA32A_XENTR 94.828 0.77027 0.660714 fam32a - Protein FAM32A - Xenopus tropicalis (Western clawed frog) - fam32a gene May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. Taurus_UMD|evm.model.AC_000185.1.233 P26234 VINC_PIG 99.295 0.998238 1 VCL - Vinculin - Sus scrofa (Pig) - VCL gene Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Taurus_UMD|evm.model.AC_000185.1.234 Q5R478 AP3M1_PONAB 100.000 0.995227 1.00239 AP3M1 - AP-3 complex subunit mu-1 - Pongo abelii (Sumatran orangutan) - AP3M1 gene Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). Taurus_UMD|evm.model.AC_000185.1.235 P55263 ADK_HUMAN 92.115 0.975439 0.787293 ADK - Adenosine kinase - Homo sapiens (Human) - ADK gene ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. Taurus_UMD|evm.model.AC_000185.1.236 P83732 RL24_RAT 90.278 0.797753 0.566879 Rpl24 - 60S ribosomal protein L24 - Rattus norvegicus (Rat) - Rpl24 gene cytoplasm, cytosolic large ribosomal subunit, cytosolic ribosome, polysomal ribosome, synapse, RNA binding, structural constituent of ribosome, assembly of large subunit precursor of preribosome, cytoplasmic translation, exit from mitosis Taurus_UMD|evm.model.AC_000185.1.237 Q8WML3 KAT6B_MACFA 98.387 0.198184 1.04933 KAT6B - Histone acetyltransferase KAT6B - Macaca fascicularis (Crab-eating macaque) - KAT6B gene Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Taurus_UMD|evm.model.AC_000185.1.238 P0C591 DUS29_BOVIN 100.000 0.990909 1.00457 DUSP29 - Dual specificity phosphatase 29 - Bos taurus (Bovine) - DUSP29 gene Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of intracellular signaling cascades. May regulate glucose metabolism by activating, AMPK, an energy sensor protein kinase. Affects MAP kinase signaling though modulation of the ERK1/2 cascade in skeletal muscle promoting muscle cell differentiation, development and atrophy (By similarity). Taurus_UMD|evm.model.AC_000185.1.239 Q9UII6 DS13B_HUMAN 92.424 0.451835 2.20202 DUSP13 - Dual specificity protein phosphatase 13 isoform B - Homo sapiens (Human) - DUSP13 gene Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro (PubMed:21360282). Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro (PubMed:10585869). Taurus_UMD|evm.model.AC_000185.1.240 Q96LT4 SAMD8_HUMAN 97.590 0.864301 1.15422 SAMD8 - Sphingomyelin synthase-related protein 1 - Homo sapiens (Human) - SAMD8 gene Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway. Taurus_UMD|evm.model.AC_000185.1.241 P68002 VDAC2_BOVIN 100.000 0.832386 1.19728 VDAC2 - Voltage-dependent anion-selective channel protein 2 - Bos taurus (Bovine) - VDAC2 gene Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (By similarity). Binding of ceramide promotes the Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (By similarity). Taurus_UMD|evm.model.AC_000185.1.242 Q86VU5 CMTD1_HUMAN 88.168 0.992395 1.00382 COMTD1 - Catechol O-methyltransferase domain-containing protein 1 - Homo sapiens (Human) - COMTD1 gene Putative O-methyltransferase. Taurus_UMD|evm.model.AC_000185.1.244 Q7TMA2 ZN503_MOUSE 98.684 0.0780437 1.47393 Znf503 - Zinc finger protein 503 - Mus musculus (Mouse) - Znf503 gene May function as a transcriptional repressor. Taurus_UMD|evm.model.AC_000185.1.245 Q9H2I8 LRMDA_HUMAN 81.905 0.693333 0.757576 LRMDA - Leucine-rich melanocyte differentiation-associated protein - Homo sapiens (Human) - LRMDA gene Required for melanocyte differentiation. Taurus_UMD|evm.model.AC_000185.1.247 P62907 RL10A_RAT 93.434 0.938095 0.967742 Rpl10a - 60S ribosomal protein L10a - Rattus norvegicus (Rat) - Rpl10a gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000185.1.248 Q28204 KCMA1_BOVIN 99.904 0.98492 0.909949 KCNMA1 - Calcium-activated potassium channel subunit alpha-1 - Bos taurus (Bovine) - KCNMA1 gene Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) (By similarity). Taurus_UMD|evm.model.AC_000185.1.249 Q8TDM6 DLG5_HUMAN 93.545 0.998959 1.00104 DLG5 - Disks large homolog 5 - Homo sapiens (Human) - DLG5 gene Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). Taurus_UMD|evm.model.AC_000185.1.251 A4IF62 RPC1_BOVIN 100.000 0.998562 1.00072 POLR3A - DNA-directed RNA polymerase III subunit RPC1 - Bos taurus (Bovine) - POLR3A gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Taurus_UMD|evm.model.AC_000185.1.252 Q5RAQ8 RS24_PONAB 100.000 0.977444 1.01527 RPS24 - 40S ribosomal protein S24 - Pongo abelii (Sumatran orangutan) - RPS24 gene Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Taurus_UMD|evm.model.AC_000185.1.258 Q9ULJ6 ZMIZ1_HUMAN 100.000 0.301948 0.28866 ZMIZ1 - Zinc finger MIZ domain-containing protein 1 - Homo sapiens (Human) - ZMIZ1 gene Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex (PubMed:16777850). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity). Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex (PubMed:30639322). Taurus_UMD|evm.model.AC_000185.1.259 Q9ULJ6 ZMIZ1_HUMAN 94.882 0.976676 0.964386 ZMIZ1 - Zinc finger MIZ domain-containing protein 1 - Homo sapiens (Human) - ZMIZ1 gene Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex (PubMed:16777850). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity). Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex (PubMed:30639322). Taurus_UMD|evm.model.AC_000185.1.260 P30404 PPIF_BOVIN 100.000 0.990431 1.00481 PPIF - Peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor - Bos taurus (Bovine) - PPIF gene PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (By similarity). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (By similarity). Taurus_UMD|evm.model.AC_000185.1.261 Q8N2G6 ZCH24_HUMAN 97.895 0.940299 0.834025 ZCCHC24 - Zinc finger CCHC domain-containing protein 24 - Homo sapiens (Human) - ZCCHC24 gene RNA binding Taurus_UMD|evm.model.AC_000185.1.263 P27214 ANX11_BOVIN 96.024 0.995876 0.964215 ANXA11 - Annexin A11 - Bos taurus (Bovine) - ANXA11 gene Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis. Taurus_UMD|evm.model.AC_000185.1.264 Q2TBK3 PLAC9_BOVIN 100.000 0.980198 1.01 PLAC9 - Placenta-specific protein 9 precursor - Bos taurus (Bovine) - PLAC9 gene Taurus_UMD|evm.model.AC_000185.1.265 Q0D2G3 TM254_BOVIN 100.000 0.938931 1.05645 TMEM254 - Transmembrane protein 254 - Bos taurus (Bovine) - TMEM254 gene Taurus_UMD|evm.model.AC_000185.1.266 A4FUH5 NDUF4_BOVIN 77.083 0.903846 0.297143 NDUFAF4 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 - Bos taurus (Bovine) - NDUFAF4 gene Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion (By similarity). Taurus_UMD|evm.model.AC_000185.1.267 P23805 CONG_BOVIN 100.000 0.994624 1.0027 CGN1 - Conglutinin precursor - Bos taurus (Bovine) - CGN1 gene Calcium-dependent lectin-like protein which binds to a yeast cell wall extract and immune complexes through the complement component (C3bi). It is capable of binding non-reducing terminal N-acetylglucosamine, mannose, and fucose residues. Taurus_UMD|evm.model.AC_000185.1.268 P42916 CL43_BOVIN 91.667 0.127737 0.853583 CL43 - Collectin-43 precursor - Bos taurus (Bovine) - CL43 gene Lectin that binds to various sugars: mannose = ManNAc > fucose > GlcNAc > glucose = maltose > galactose > lactose > GalNAc. Could play a role in immune defense. Taurus_UMD|evm.model.AC_000185.1.269 Q8MHZ9 CL46_BOVIN 99.664 0.430435 1.85984 CL46 - Collectin-46 precursor - Bos taurus (Bovine) - CL46 gene extracellular space, multivesicular body, rough endoplasmic reticulum, positive regulation of phagocytosis, surfactant homeostasis Taurus_UMD|evm.model.AC_000185.1.270 P42916 CL43_BOVIN 93.023 0.921739 0.716511 CL43 - Collectin-43 precursor - Bos taurus (Bovine) - CL43 gene Lectin that binds to various sugars: mannose = ManNAc > fucose > GlcNAc > glucose = maltose > galactose > lactose > GalNAc. Could play a role in immune defense. Taurus_UMD|evm.model.AC_000185.1.271 P23805 CONG_BOVIN 81.166 0.990868 0.590296 CGN1 - Conglutinin precursor - Bos taurus (Bovine) - CGN1 gene Calcium-dependent lectin-like protein which binds to a yeast cell wall extract and immune complexes through the complement component (C3bi). It is capable of binding non-reducing terminal N-acetylglucosamine, mannose, and fucose residues. Taurus_UMD|evm.model.AC_000185.1.272 P35246 SFTPD_BOVIN 100.000 0.994595 1.00271 SFTPD - Pulmonary surfactant-associated protein D precursor - Bos taurus (Bovine) - SFTPD gene Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. Taurus_UMD|evm.model.AC_000185.1.273 Q6RXL1 SFTPA_BOVIN 99.194 0.501014 1.9879 SFTPA1 - Pulmonary surfactant-associated protein A precursor - Bos taurus (Bovine) - SFTPA1 gene In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages. Taurus_UMD|evm.model.AC_000185.1.274 Q2KJC6 METK1_BOVIN 99.747 0.994962 1.00253 MAT1A - S-adenosylmethionine synthase isoform type-1 - Bos taurus (Bovine) - MAT1A gene Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. Taurus_UMD|evm.model.AC_000185.1.275 Q32LH1 DYDC1_BOVIN 100.000 0.988636 1.00571 DYDC1 - DPY30 domain-containing protein 1 - Bos taurus (Bovine) - DYDC1 gene Plays a crucial role during acrosome biogenesis. Taurus_UMD|evm.model.AC_000185.1.276 Q2KIW3 DYDC2_BOVIN 100.000 0.989744 1.00515 DYDC2 - DPY30 domain-containing protein 2 - Bos taurus (Bovine) - DYDC2 gene Set1C/COMPASS complex, chromatin silencing at telomere, histone H3-K4 methylation Taurus_UMD|evm.model.AC_000185.1.277 Q3ZBK2 PXL2A_BOVIN 100.000 0.628986 1.58257 PRXL2A - Peroxiredoxin-like 2A - Bos taurus (Bovine) - PRXL2A gene Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway. Taurus_UMD|evm.model.AC_000185.1.278 Q8NG11 TSN14_HUMAN 91.852 0.992126 0.940741 TSPAN14 - Tetraspanin-14 - Homo sapiens (Human) - TSPAN14 gene Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26668317, PubMed:23035126, PubMed:26686862). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity). Taurus_UMD|evm.model.AC_000185.1.279 Q5SQS7 SH24B_HUMAN 94.412 0.673956 1.16705 SH2D4B - SH2 domain-containing protein 4B - Homo sapiens (Human) - SH2D4B gene cytoplasm Taurus_UMD|evm.model.AC_000185.1.280 P23438 SSRB_CANLF 59.375 0.983051 0.644809 SSR2 - Translocon-associated protein subunit beta precursor - Canis lupus familiaris (Dog) - SSR2 gene TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Taurus_UMD|evm.model.AC_000185.1.281 O35181 NRG3_MOUSE 97.101 0.730496 0.395512 Nrg3 - Pro-neuregulin-3, membrane-bound isoform precursor - Mus musculus (Mouse) - Nrg3 gene Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. Taurus_UMD|evm.model.AC_000185.1.283 P56975 NRG3_HUMAN 87.500 0.994334 0.490278 NRG3 - Pro-neuregulin-3, membrane-bound isoform precursor - Homo sapiens (Human) - NRG3 gene Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. Taurus_UMD|evm.model.AC_000185.1.284 Q9GZN1 ARP6_HUMAN 87.597 0.984615 0.328283 ACTR6 - Actin-related protein 6 - Homo sapiens (Human) - ACTR6 gene nucleus, Swr1 complex, nucleosome binding, histone exchange Taurus_UMD|evm.model.AC_000185.1.285 Q9HCE3 ZN532_HUMAN 88.112 0.946667 0.115296 ZNF532 - Zinc finger protein 532 - Homo sapiens (Human) - ZNF532 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000185.1.288 Q9H3K2 GHITM_HUMAN 93.913 0.99422 1.0029 GHITM - Growth hormone-inducible transmembrane protein precursor - Homo sapiens (Human) - GHITM gene Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c. Taurus_UMD|evm.model.AC_000185.1.289 I3LGZ3 GL15L_PIG 75.309 0.97561 1.01235 GPRL15 - Protein GPR15L precursor - Sus scrofa (Pig) - GPRL15 gene Chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (By similarity). Taurus_UMD|evm.model.AC_000185.1.290 Q8WN91 CDHR1_BOVIN 99.424 0.997699 1.00231 CDHR1 - Cadherin-related family member 1 precursor - Bos taurus (Bovine) - CDHR1 gene Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity). Taurus_UMD|evm.model.AC_000185.1.291 A6NDA9 LRIT2_HUMAN 78.040 0.976868 1.02182 LRIT2 - Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 precursor - Homo sapiens (Human) - LRIT2 gene Taurus_UMD|evm.model.AC_000185.1.292 Q8K099 LRIT1_MOUSE 80.449 0.99679 0.998397 Lrit1 - Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 precursor - Mus musculus (Mouse) - Lrit1 gene Possible role in phototransduction. Taurus_UMD|evm.model.AC_000185.1.293 P47803 RGR_BOVIN 100.000 0.993151 1.00344 RGR - RPE-retinal G protein-coupled receptor - Bos taurus (Bovine) - RGR gene Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism. Taurus_UMD|evm.model.AC_000185.1.294 P08166 KAD2_BOVIN 90.244 0.987879 0.684647 AK2 - Adenylate kinase 2, mitochondrial - Bos taurus (Bovine) - AK2 gene Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. Taurus_UMD|evm.model.AC_000185.1.295 Q9H7U1 CCSE2_HUMAN 90.168 0.997605 1.0012 CCSER2 - Serine-rich coiled-coil domain-containing protein 2 - Homo sapiens (Human) - CCSER2 gene Microtubule-binding protein which might play a role in microtubule bundling. Taurus_UMD|evm.model.AC_000185.1.299 Q9ULK0 GRID1_HUMAN 98.997 0.99005 0.597621 GRID1 - Glutamate receptor ionotropic, delta-1 precursor - Homo sapiens (Human) - GRID1 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Taurus_UMD|evm.model.AC_000185.1.300 Q62640 GRID1_RAT 93.085 0.805195 0.22894 Grid1 - Glutamate receptor ionotropic, delta-1 precursor - Rattus norvegicus (Rat) - Grid1 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Taurus_UMD|evm.model.AC_000185.1.302 Q62640 GRID1_RAT 100.000 0.867725 0.187314 Grid1 - Glutamate receptor ionotropic, delta-1 precursor - Rattus norvegicus (Rat) - Grid1 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Taurus_UMD|evm.model.AC_000185.1.304 Q62640 GRID1_RAT 96.296 0.32716 0.160555 Grid1 - Glutamate receptor ionotropic, delta-1 precursor - Rattus norvegicus (Rat) - Grid1 gene Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Taurus_UMD|evm.model.AC_000185.1.306 Q7Z5K2 WAPL_HUMAN 94.900 0.896915 1.11681 WAPL - Wings apart-like protein homolog - Homo sapiens (Human) - WAPL gene Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Taurus_UMD|evm.model.AC_000185.1.307 Q9JKS4 LDB3_MOUSE 87.500 0.487179 2.04979 Ldb3 - LIM domain-binding protein 3 - Mus musculus (Mouse) - Ldb3 gene May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. Taurus_UMD|evm.model.AC_000185.1.309 P36894 BMR1A_HUMAN 98.308 0.996248 1.00188 BMPR1A - Bone morphogenetic protein receptor type-1A precursor - Homo sapiens (Human) - BMPR1A gene On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. Taurus_UMD|evm.model.AC_000185.1.310 Q9H8L6 MMRN2_HUMAN 74.737 0.997856 0.98314 MMRN2 - Multimerin-2 precursor - Homo sapiens (Human) - MMRN2 gene Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA. Taurus_UMD|evm.model.AC_000185.1.311 Q9NZ50 SYUG_BOVIN 100.000 0.984375 1.00787 SNCG - Gamma-synuclein - Bos taurus (Bovine) - SNCG gene Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. Taurus_UMD|evm.model.AC_000185.1.312 Q15847 ADIRF_HUMAN 85.526 0.974026 1.01316 ADIRF - Adipogenesis regulatory factor - Homo sapiens (Human) - ADIRF gene Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin. Taurus_UMD|evm.model.AC_000185.1.314 P00366 DHE3_BOVIN 97.326 0.996441 1.00717 GLUD1 - Glutamate dehydrogenase 1, mitochondrial precursor - Bos taurus (Bovine) - GLUD1 gene Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:4365183, PubMed:14659072). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). Taurus_UMD|evm.model.AC_000185.1.315 Q86V20 SHLD2_HUMAN 76.216 0.207207 1.06347 SHLD2 - Shieldin complex subunit 2 - Homo sapiens (Human) - SHLD2 gene Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). Taurus_UMD|evm.model.AC_000185.1.316 Q9BQS2 SYT15_HUMAN 78.385 0.995181 0.985748 SYT15 - Synaptotagmin-15 - Homo sapiens (Human) - SYT15 gene May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Taurus_UMD|evm.model.AC_000185.1.317 O60269 GRIN2_HUMAN 77.511 0.995595 0.991266 GPRIN2 - G protein-regulated inducer of neurite outgrowth 2 - Homo sapiens (Human) - GPRIN2 gene May be involved in neurite outgrowth. Taurus_UMD|evm.model.AC_000185.1.319 P50391 NPY4R_HUMAN 86.207 0.994709 1.008 NPY4R - Neuropeptide Y receptor type 4 - Homo sapiens (Human) - NPY4R gene Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid. Taurus_UMD|evm.model.AC_000185.1.320 Q9CPX9 APC11_MOUSE 98.701 0.95 0.952381 Anapc11 - Anaphase-promoting complex subunit 11 - Mus musculus (Mouse) - Anapc11 gene Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). Taurus_UMD|evm.model.AC_000185.1.321 Q95L54 ANXA8_BOVIN 100.000 0.993902 1.00306 ANXA8 - Annexin A8 - Bos taurus (Bovine) - ANXA8 gene This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Taurus_UMD|evm.model.AC_000185.1.322 Q9H6X2 ANTR1_HUMAN 48.780 0.489655 1.02837 ANTXR1 - Anthrax toxin receptor 1 precursor - Homo sapiens (Human) - ANTXR1 gene Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. Taurus_UMD|evm.model.AC_000185.1.323 O88799 ZAN_MOUSE 36.481 0.193576 0.214286 Zan - Zonadhesin precursor - Mus musculus (Mouse) - Zan gene Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling. Taurus_UMD|evm.model.AC_000185.1.326 A6NF34 ANTRL_HUMAN 40.426 0.85214 0.40729 ANTXRL - Anthrax toxin receptor-like precursor - Homo sapiens (Human) - ANTXRL gene cell surface, plasma membrane, transmembrane signaling receptor activity, toxin transport Taurus_UMD|evm.model.AC_000185.1.327 Q8BVM2 ANTRL_MOUSE 40.636 0.469799 0.929797 Antxrl - Anthrax toxin receptor-like precursor - Mus musculus (Mouse) - Antxrl gene cell surface, plasma membrane, transmembrane signaling receptor activity, toxin transport Taurus_UMD|evm.model.AC_000185.1.328 A6NF34 ANTRL_HUMAN 65.000 0.047503 1.30111 ANTXRL - Anthrax toxin receptor-like precursor - Homo sapiens (Human) - ANTXRL gene cell surface, plasma membrane, transmembrane signaling receptor activity, toxin transport Taurus_UMD|evm.model.AC_000185.1.329 Q8BZ97 PRDM8_MOUSE 72.340 0.141538 0.473071 Prdm8 - PR domain zinc finger protein 8 - Mus musculus (Mouse) - Prdm8 gene Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (PubMed:19646955). Histone methyltransferase activity has not been confirmed in other species. Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (PubMed:19646955). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (PubMed:22284184). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (PubMed:26023183). Taurus_UMD|evm.model.AC_000185.1.330 P12661 RET3_BOVIN 99.689 0.998446 1.00078 RBP3 - Retinol-binding protein 3 precursor - Bos taurus (Bovine) - RBP3 gene IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. Taurus_UMD|evm.model.AC_000185.1.331 Q9UK05 GDF2_HUMAN 80.046 0.99537 1.00699 GDF2 - Growth/differentiation factor 2 precursor - Homo sapiens (Human) - GDF2 gene Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. Taurus_UMD|evm.model.AC_000185.1.332 P06899 H2B1J_HUMAN 97.321 0.822222 1.07143 H2BC11 - Histone H2B type 1-J - Homo sapiens (Human) - H2BC11 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000185.1.333 Q08DX6 GDF10_BOVIN 100.000 0.995825 1.00209 GDF10 - Growth/differentiation factor 10 precursor - Bos taurus (Bovine) - GDF10 gene Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis. Taurus_UMD|evm.model.AC_000185.1.334 Q4JDL3 PTN20_HUMAN 61.209 0.867882 1.04524 PTPN20 - Tyrosine-protein phosphatase non-receptor type 20 - Homo sapiens (Human) - PTPN20 gene Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates. Taurus_UMD|evm.model.AC_000185.1.335 Q6IN97 FRP2L_HUMAN 80.471 0.210227 4.4 FRMPD2B - Putative protein FRMPD2-like - Homo sapiens (Human) - FRMPD2B gene Taurus_UMD|evm.model.AC_000185.1.337 P45983 MK08_HUMAN 97.190 0.995327 1.00234 MAPK8 - Mitogen-activated protein kinase 8 - Homo sapiens (Human) - MAPK8 gene Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity (PubMed:18307971). Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins (PubMed:21856198). Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1 (PubMed:21364637). In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation (PubMed:21095239). Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy (PubMed:18570871). Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH (PubMed:20027304, PubMed:17296730, PubMed:16581800). Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (By similarity). Phosphorylates EIF4ENIF1/4-ET in response to oxidative stress, promoting P-body assembly (PubMed:22966201). Taurus_UMD|evm.model.AC_000185.1.338 Q7Z5H3 RHG22_HUMAN 86.331 0.988604 1.00573 ARHGAP22 - Rho GTPase-activating protein 22 - Homo sapiens (Human) - ARHGAP22 gene Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). Taurus_UMD|evm.model.AC_000185.1.340 Q6ZS81 WDFY4_HUMAN 83.130 0.99936 0.981784 WDFY4 - WD repeat- and FYVE domain-containing protein 4 - Homo sapiens (Human) - WDFY4 gene Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking. Plays also a role in B-cell survival through regulation of autophagy. Taurus_UMD|evm.model.AC_000185.1.341 Q8IW00 VSTM4_HUMAN 91.060 0.9375 1 VSTM4 - V-set and transmembrane domain-containing protein 4 precursor - Homo sapiens (Human) - VSTM4 gene Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors. Taurus_UMD|evm.model.AC_000185.1.342 A6NMN3 F170B_HUMAN 68.056 0.989655 1.02473 FAM170B - Protein FAM170B - Homo sapiens (Human) - FAM170B gene Plays a role in fertilization through the acrosome reaction. Taurus_UMD|evm.model.AC_000185.1.343 Q5T292 TM273_HUMAN 69.620 0.75 0.990476 TMEM273 - Transmembrane protein 273 precursor - Homo sapiens (Human) - TMEM273 gene Taurus_UMD|evm.model.AC_000185.1.345 Q711Q0 CEFIP_HUMAN 71.359 0.998606 1 CEFIP - Cardiac-enriched FHL2-interacting protein - Homo sapiens (Human) - CEFIP gene Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Taurus_UMD|evm.model.AC_000185.1.346 Q8BYH0 DRGX_MOUSE 98.857 0.466488 1.41825 Drgx - Dorsal root ganglia homeobox protein - Mus musculus (Mouse) - Drgx gene Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain. Taurus_UMD|evm.model.AC_000185.1.347 Q03468 ERCC6_HUMAN 75.936 0.998585 0.946417 ERCC6 - DNA excision repair protein ERCC-6 - Homo sapiens (Human) - ERCC6 gene Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:20541997, PubMed:26620705, PubMed:16246722). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). It is required for transcription-coupled repair complex formation (PubMed:16916636). It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the sites of RNA polymerase II-blocking lesions (PubMed:16916636). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function. Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). Taurus_UMD|evm.model.AC_000185.1.348 Q16572 VACHT_HUMAN 87.030 0.99619 0.986842 SLC18A3 - Vesicular acetylcholine transporter - Homo sapiens (Human) - SLC18A3 gene Involved in acetylcholine transport into synaptic vesicles. Taurus_UMD|evm.model.AC_000185.1.349 P13222 CLAT_PIG 85.981 0.954911 0.968799 CHAT - Choline O-acetyltransferase - Sus scrofa (Pig) - CHAT gene Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Taurus_UMD|evm.model.AC_000185.1.350 P0C920 CJ053_BOVIN 100.000 0.978723 1.01075 UPF0728 protein C10orf53 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000185.1.351 Q9ULD0 OGDHL_HUMAN 94.554 0.998022 1.00099 OGDHL - 2-oxoglutarate dehydrogenase-like, mitochondrial precursor - Homo sapiens (Human) - OGDHL gene 2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH (By similarity). The OGDHC complex is mainly active in the mitochondrion (By similarity). Involved in the inhibition of cell proliferation and in apoptosis (PubMed:23152800, PubMed:31175094). Taurus_UMD|evm.model.AC_000185.1.352 O02776 PARG_BOVIN 99.898 0.997955 1.00102 PARG - Poly(ADP-ribose) glycohydrolase - Bos taurus (Bovine) - PARG gene Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15658938). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress. Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond. Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). Taurus_UMD|evm.model.AC_000185.1.353 A4IFL0 TIM23_BOVIN 100.000 0.990476 1.00478 TIMM23 - Mitochondrial import inner membrane translocase subunit Tim23 - Bos taurus (Bovine) - TIMM23 gene Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Taurus_UMD|evm.model.AC_000185.1.354 Q13772 NCOA4_HUMAN 82.616 0.99681 1.02117 NCOA4 - Nuclear receptor coactivator 4 - Homo sapiens (Human) - NCOA4 gene Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Taurus_UMD|evm.model.AC_000185.1.355 O02826 MSMB_PIG 64.865 0.909091 1.09009 MSMB - Beta-microseminoprotein precursor - Sus scrofa (Pig) - MSMB gene Taurus_UMD|evm.model.AC_000185.1.356 Q641Q2 WAC2A_HUMAN 79.285 0.998501 0.99478 WASHC2A - WASH complex subunit 2A - Homo sapiens (Human) - WASHC2A gene Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. Taurus_UMD|evm.model.AC_000185.1.357 D3Z3C6 ZFAN4_MOUSE 77.203 0.997203 0.967524 Zfand4 - AN1-type zinc finger protein 4 - Mus musculus (Mouse) - Zfand4 gene Taurus_UMD|evm.model.AC_000185.1.358 Q0VD59 MARH8_BOVIN 100.000 0.993103 1.00346 MARCHF8 - E3 ubiquitin-protein ligase MARCHF8 - Bos taurus (Bovine) - MARCHF8 gene E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS. Taurus_UMD|evm.model.AC_000185.1.359 P09917 LOX5_HUMAN 91.988 0.997037 1.00148 ALOX5 - Polyunsaturated fatty acid 5-lipoxygenase - Homo sapiens (Human) - ALOX5 gene Catalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation (PubMed:8631361, PubMed:21233389, PubMed:22516296, PubMed:24282679, PubMed:19022417, PubMed:23246375, PubMed:8615788, PubMed:24893149, PubMed:31664810). Also catalyzes the oxygenation of arachidonate into 8-hydroperoxyicosatetraenoate (8-HPETE) and 12-hydroperoxyicosatetraenoate (12-HPETE) (PubMed:23246375). Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene (PubMed:31664810). Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses (PubMed:21206090, PubMed:31664810, PubMed:8615788, PubMed:17114001, PubMed:32404334). Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma) (By similarity). It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers (PubMed:31664810). In addition to inflammatory processes, it participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes (By similarity). Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40 (PubMed:21200133). Also may play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (By similarity). Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells (By similarity). Taurus_UMD|evm.model.AC_000185.1.360 Q1LZC0 ZNF22_BOVIN 100.000 0.952941 0.755556 ZNF22 - Zinc finger protein 22 - Bos taurus (Bovine) - ZNF22 gene Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity). Taurus_UMD|evm.model.AC_000185.1.361 Q9H2L5 RASF4_HUMAN 84.424 0.686147 1.43925 RASSF4 - Ras association domain-containing protein 4 - Homo sapiens (Human) - RASSF4 gene Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest. Taurus_UMD|evm.model.AC_000185.1.362 A0PK05 TMM72_HUMAN 87.308 0.992308 0.945455 TMEM72 - Transmembrane protein 72 - Homo sapiens (Human) - TMEM72 gene Taurus_UMD|evm.model.AC_000185.1.364 P48061 SDF1_HUMAN 92.135 0.733333 1.29032 CXCL12 - Stromal cell-derived factor 1 precursor - Homo sapiens (Human) - CXCL12 gene Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity). Taurus_UMD|evm.model.AC_000185.1.369 P82185 DCAM2_MUSSP 52.632 0.821705 0.386228 Amd2 - S-adenosylmethionine decarboxylase proenzyme 2 precursor - Mus spretus (Western Mediterranean mouse) - Amd2 gene Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. Taurus_UMD|evm.model.AC_000185.1.370 Q02543 RL18A_HUMAN 69.091 0.614458 0.471591 RPL18A - 60S ribosomal protein L18a - Homo sapiens (Human) - RPL18A gene cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, polysomal ribosome, RNA binding, structural constituent of ribosome, cytoplasmic translation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, rRNA processing Taurus_UMD|evm.model.AC_000185.1.371 P17041 ZNF32_HUMAN 92.683 0.993056 1.05495 ZNF32 - Zinc finger protein 32 - Homo sapiens (Human) - ZNF32 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000185.1.373 Q16600 ZN239_HUMAN 79.259 0.992593 0.884279 ZNF239 - Zinc finger protein 239 - Homo sapiens (Human) - ZNF239 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000185.1.374 Q0II87 TFAM_BOVIN 99.593 0.991903 1.00407 TFAM - Transcription factor A, mitochondrial precursor - Bos taurus (Bovine) - TFAM gene Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. Taurus_UMD|evm.model.AC_000185.1.375 O35920 CAN9_RAT 88.889 0.238532 0.157971 Capn9 - Calpain-9 - Rattus norvegicus (Rat) - Capn9 gene Calcium-regulated non-lysosomal thiol-protease. Taurus_UMD|evm.model.AC_000185.1.376 P01017 ANGT_BOVIN 100.000 0.995807 1.0021 AGT - Angiotensinogen precursor - Bos taurus (Bovine) - AGT gene Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Taurus_UMD|evm.model.AC_000185.1.377 Q14746 COG2_HUMAN 89.581 0.997297 1.00271 COG2 - Conserved oligomeric Golgi complex subunit 2 - Homo sapiens (Human) - COG2 gene Required for normal Golgi morphology and function. Taurus_UMD|evm.model.AC_000186.1.1 Q9UPS8 ANR26_HUMAN 49.551 0.671315 0.587135 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000186.1.2 Q9BQI4 CCDC3_HUMAN 79.412 0.705263 0.351852 CCDC3 - Coiled-coil domain-containing protein 3 precursor - Homo sapiens (Human) - CCDC3 gene Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (PubMed:25193116). Positively regulates lipid accumulation in adipose cells (By similarity). Taurus_UMD|evm.model.AC_000186.1.3 Q9UPS8 ANR26_HUMAN 73.077 0.908451 0.0830409 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000186.1.4 Q9H560 ANR19_HUMAN 55.556 0.539394 0.625 ANKRD19P - Putative ankyrin repeat domain-containing protein 19 - Homo sapiens (Human) - ANKRD19P gene Taurus_UMD|evm.model.AC_000186.1.5 Q63610 TPM3_RAT 95.968 0.991968 1.00403 Tpm3 - Tropomyosin alpha-3 chain - Rattus norvegicus (Rat) - Tpm3 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Taurus_UMD|evm.model.AC_000186.1.6 Q9UPS8 ANR26_HUMAN 62.554 0.982719 0.507602 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.AC_000186.1.7 Q96RD7 PANX1_HUMAN 82.201 0.995294 0.997653 PANX1 - Pannexin-1 - Homo sapiens (Human) - PANX1 gene Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation (PubMed:16908669, PubMed:20829356, PubMed:30918116). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669). Plays a critical role in oogenesis (PubMed:30918116). Taurus_UMD|evm.model.AC_000186.1.8 Q6MZM0 HPHL1_HUMAN 89.130 0.990099 0.958585 HEPHL1 - Ferroxidase HEPHL1 precursor - Homo sapiens (Human) - HEPHL1 gene Is a copper-binding glycoprotein with ferroxidase activity. It oxidizes Fe(2+) to Fe(3+) without releasing radical oxygen species (PubMed:31125343). May be involved in the regulation of intracellular iron content (PubMed:31125343). Taurus_UMD|evm.model.AC_000186.1.10 A8MXK1 VSTM5_HUMAN 87.000 0.99005 1.005 VSTM5 - V-set and transmembrane domain-containing protein 5 precursor - Homo sapiens (Human) - VSTM5 gene Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain. Taurus_UMD|evm.model.AC_000186.1.11 Q5BIR6 MED17_BOVIN 100.000 0.996933 1.00154 MED17 - Mediator of RNA polymerase II transcription subunit 17 - Bos taurus (Bovine) - MED17 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Taurus_UMD|evm.model.AC_000186.1.12 Q2HJH3 CK054_BOVIN 100.000 0.993671 1.00317 Ester hydrolase C11orf54 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.13 Q32LB6 TAF1D_BOVIN 100.000 0.992727 1.00365 TAF1D - TATA box-binding protein-associated factor RNA polymerase I subunit D - Bos taurus (Bovine) - TAF1D gene Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity). Taurus_UMD|evm.model.AC_000186.1.14 Q9C0D2 CE295_HUMAN 69.251 0.978186 1.00461 CEP295 - Centrosomal protein of 295 kDa - Homo sapiens (Human) - CEP295 gene Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865). Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865). Taurus_UMD|evm.model.AC_000186.1.16 Q95JK1 DEUP1_MACFA 83.824 0.986755 1.00166 DEUP1 - Deuterosome assembly protein 1 - Macaca fascicularis (Crab-eating macaque) - DEUP1 gene Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). Taurus_UMD|evm.model.AC_000186.1.17 Q6YBV0 S36A4_HUMAN 92.653 0.970238 1 SLC36A4 - Proton-coupled amino acid transporter 4 - Homo sapiens (Human) - SLC36A4 gene Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine. Taurus_UMD|evm.model.AC_000186.1.18 P49286 MTR1B_HUMAN 75.824 0.962865 1.04144 MTNR1B - Melatonin receptor type 1B - Homo sapiens (Human) - MTNR1B gene High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Taurus_UMD|evm.model.AC_000186.1.19 P68105 EF1A1_RABIT 79.903 0.93765 0.902597 EEF1A1 - Elongation factor 1-alpha 1 - Oryctolagus cuniculus (Rabbit) - EEF1A1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000186.1.20 Q8TDW7 FAT3_HUMAN 92.571 0.99674 1.00966 FAT3 - Protocadherin Fat 3 precursor - Homo sapiens (Human) - FAT3 gene May play a role in the interactions between neurites derived from specific subsets of neurons during development. Taurus_UMD|evm.model.AC_000186.1.22 Q2T9M4 DRC7_BOVIN 81.132 0.436975 0.136468 DRC7 - Dynein regulatory complex subunit 7 - Bos taurus (Bovine) - DRC7 gene Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility. Taurus_UMD|evm.model.AC_000186.1.23 P08166 KAD2_BOVIN 66.207 0.985816 0.585062 AK2 - Adenylate kinase 2, mitochondrial - Bos taurus (Bovine) - AK2 gene Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. Taurus_UMD|evm.model.AC_000186.1.24 Q29RL2 CHRD1_BOVIN 100.000 0.993994 1.00301 CHORDC1 - Cysteine and histidine-rich domain-containing protein 1 - Bos taurus (Bovine) - CHORDC1 gene Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (By similarity). Involved in stress response. Prevents tumorigenesis (By similarity). Taurus_UMD|evm.model.AC_000186.1.25 Q9Y3Q0 NALD2_HUMAN 86.351 0.997301 1.00135 NAALAD2 - N-acetylated-alpha-linked acidic dipeptidase 2 - Homo sapiens (Human) - NAALAD2 gene Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate. Taurus_UMD|evm.model.AC_000186.1.26 P0CB47 UBFL1_HUMAN 59.946 0.420323 2.20356 UBTFL1 - Upstream-binding factor 1-like protein 1 - Homo sapiens (Human) - UBTFL1 gene Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development. Taurus_UMD|evm.model.AC_000186.1.27 Q9D2X5 SCC4_MOUSE 46.970 0.454545 0.462036 Mau2 - MAU2 chromatid cohesion factor homolog - Mus musculus (Mouse) - Mau2 gene Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodim. eric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin Plays a role in sister chromatid cohesion and normal progression through prometaphase. Taurus_UMD|evm.model.AC_000186.1.28 A6NGJ6 TRI64_HUMAN 60.356 0.988962 1.00891 TRIM64 - Tripartite motif-containing protein 64 - Homo sapiens (Human) - TRIM64 gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Taurus_UMD|evm.model.AC_000186.1.29 Q5VWM5 PRAM9_HUMAN 38.583 0.556886 0.349372 PRAMEF9 - PRAME family member 9/15 - Homo sapiens (Human) - PRAMEF9 gene cytoplasm Taurus_UMD|evm.model.AC_000186.1.30 Q5VT98 PRA20_HUMAN 50.756 0.974522 0.991579 PRAMEF20 - PRAME family member 20 - Homo sapiens (Human) - PRAMEF20 gene cytoplasm Taurus_UMD|evm.model.AC_000186.1.31 Q5VWM4 PRAM8_HUMAN 41.284 0.640569 0.592827 PRAMEF8 - PRAME family member 8 - Homo sapiens (Human) - PRAMEF8 gene cytoplasm Taurus_UMD|evm.model.AC_000186.1.32 O95522 PRA12_HUMAN 63.636 0.287671 0.302277 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Taurus_UMD|evm.model.AC_000186.1.33 P25976 UBF1_MOUSE 57.895 0.645714 0.228758 Ubtf - Nucleolar transcription factor 1 - Mus musculus (Mouse) - Ubtf gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. Taurus_UMD|evm.model.AC_000186.1.34 A6NLI5 TR64C_HUMAN 56.233 0.980057 0.78 TRIM64C - Tripartite motif-containing protein 64C - Homo sapiens (Human) - TRIM64C gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Taurus_UMD|evm.model.AC_000186.1.35 P25980 UBF1B_XENLA 61.667 0.204861 0.410842 ubtf-b - Nucleolar transcription factor 1-B - Xenopus laevis (African clawed frog) - ubtf-b gene UBF recognizes the ribosomal RNA gene promotor and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. It binds specifically to the upstream control element. Taurus_UMD|evm.model.AC_000186.1.37 P25976 UBF1_MOUSE 56.250 0.149206 0.411765 Ubtf - Nucleolar transcription factor 1 - Mus musculus (Mouse) - Ubtf gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. Taurus_UMD|evm.model.AC_000186.1.38 A6NGJ6 TRI64_HUMAN 57.143 0.264583 2.13808 TRIM64 - Tripartite motif-containing protein 64 - Homo sapiens (Human) - TRIM64 gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Taurus_UMD|evm.model.AC_000186.1.39 P25976 UBF1_MOUSE 62.385 0.311239 0.453595 Ubtf - Nucleolar transcription factor 1 - Mus musculus (Mouse) - Ubtf gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. Taurus_UMD|evm.model.AC_000186.1.40 A6NI03 TR64B_HUMAN 56.024 0.964497 0.376392 TRIM64B - Putative tripartite motif-containing protein 64B - Homo sapiens (Human) - TRIM64B gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Taurus_UMD|evm.model.AC_000186.1.41 P25977 UBF1_RAT 61.404 0.582474 0.253927 Ubtf - Nucleolar transcription factor 1 - Rattus norvegicus (Rat) - Ubtf gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element (By similarity). Taurus_UMD|evm.model.AC_000186.1.42 Q5VWM5 PRAM9_HUMAN 44.828 0.206989 0.778243 PRAMEF9 - PRAME family member 9/15 - Homo sapiens (Human) - PRAMEF9 gene cytoplasm Taurus_UMD|evm.model.AC_000186.1.43 P25980 UBF1B_XENLA 65.000 0.188498 0.446505 ubtf-b - Nucleolar transcription factor 1-B - Xenopus laevis (African clawed frog) - ubtf-b gene UBF recognizes the ribosomal RNA gene promotor and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. It binds specifically to the upstream control element. Taurus_UMD|evm.model.AC_000186.1.44 I1YAP6 TRI77_HUMAN 47.955 0.964029 0.617778 TRIM77 - Tripartite motif-containing protein 77 - Homo sapiens (Human) - TRIM77 gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Taurus_UMD|evm.model.AC_000186.1.45 P25977 UBF1_RAT 56.863 0.34965 0.187173 Ubtf - Nucleolar transcription factor 1 - Rattus norvegicus (Rat) - Ubtf gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element (By similarity). Taurus_UMD|evm.model.AC_000186.1.46 O95522 PRA12_HUMAN 59.524 0.0439914 1.92961 PRAMEF12 - PRAME family member 12 - Homo sapiens (Human) - PRAMEF12 gene cytoplasm Taurus_UMD|evm.model.AC_000186.1.47 P17480 UBF1_HUMAN 58.696 0.451852 0.530105 UBTF - Nucleolar transcription factor 1 - Homo sapiens (Human) - UBTF gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. Taurus_UMD|evm.model.AC_000186.1.48 P25977 UBF1_RAT 53.247 0.475 0.209424 Ubtf - Nucleolar transcription factor 1 - Rattus norvegicus (Rat) - Ubtf gene Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element (By similarity). Taurus_UMD|evm.model.AC_000186.1.49 A6NGJ6 TRI64_HUMAN 58.837 0.988864 1 TRIM64 - Tripartite motif-containing protein 64 - Homo sapiens (Human) - TRIM64 gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Taurus_UMD|evm.model.AC_000186.1.50 Q96BQ3 TRI43_HUMAN 49.818 0.992754 0.618834 TRIM43 - Tripartite motif-containing protein 43 - Homo sapiens (Human) - TRIM43 gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Taurus_UMD|evm.model.AC_000186.1.51 A6NI03 TR64B_HUMAN 50.769 0.507874 0.565702 TRIM64B - Putative tripartite motif-containing protein 64B - Homo sapiens (Human) - TRIM64B gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Taurus_UMD|evm.model.AC_000186.1.52 Q96BQ3 TRI43_HUMAN 47.750 0.935407 0.93722 TRIM43 - Tripartite motif-containing protein 43 - Homo sapiens (Human) - TRIM43 gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Taurus_UMD|evm.model.AC_000186.1.53 P0CB48 UBFL6_HUMAN 65.306 0.60625 0.4 UBTFL6 - Putative upstream-binding factor 1-like protein 6 - Homo sapiens (Human) - UBTFL6 gene Taurus_UMD|evm.model.AC_000186.1.54 A6NLI5 TR64C_HUMAN 59.152 0.982262 1.00222 TRIM64C - Tripartite motif-containing protein 64C - Homo sapiens (Human) - TRIM64C gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Taurus_UMD|evm.model.AC_000186.1.55 A6NGJ6 TRI64_HUMAN 58.613 0.988914 1.00445 TRIM64 - Tripartite motif-containing protein 64 - Homo sapiens (Human) - TRIM64 gene cytoplasm, ubiquitin protein ligase activity, innate immune response, protein ubiquitination, regulation of gene expression Taurus_UMD|evm.model.AC_000186.1.56 O77564 FOLH1_PIG 92.810 0.997337 1 FOLH1 - Glutamate carboxypeptidase 2 - Sus scrofa (Pig) - FOLH1 gene Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Taurus_UMD|evm.model.AC_000186.1.57 Q5R5C5 NOX4_PONAB 82.075 0.99569 0.802768 NOX4 - NADPH oxidase 4 - Pongo abelii (Sumatran orangutan) - NOX4 gene Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (By similarity). Taurus_UMD|evm.model.AC_000186.1.58 Q8MIU0 TYRO_BOVIN 99.811 0.996234 1.00189 TYR - Tyrosinase precursor - Bos taurus (Bovine) - TYR gene This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (By similarity). Taurus_UMD|evm.model.AC_000186.1.59 P31424 GRM5_RAT 99.142 0.383663 1.00748 Grm5 - Metabotropic glutamate receptor 5 precursor - Rattus norvegicus (Rat) - Grm5 gene G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. Taurus_UMD|evm.model.AC_000186.1.60 O19110 TSPY1_BOVIN 66.667 0.121019 0.990536 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000186.1.61 Q5R893 H2B1_PONAB 94.444 0.984252 1.00794 Histone H2B type 1 - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000186.1.62 Q3ZCJ8 CATC_BOVIN 99.784 0.99569 1.00216 CTSC - Dipeptidyl peptidase 1 precursor - Bos taurus (Bovine) - CTSC gene Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function (By similarity). Taurus_UMD|evm.model.AC_000186.1.63 Q8QZZ8 RAB38_MOUSE 95.735 0.990566 1.00474 Rab38 - Ras-related protein Rab-38 - Mus musculus (Mouse) - Rab38 gene Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (PubMed:21187289). Plays an important role in the control of melanin production and melanosome biogenesis (By similarity). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (PubMed:26620560). Taurus_UMD|evm.model.AC_000186.1.64 Q2HJ47 DENR_BOVIN 100.000 0.98995 1.00505 DENR - Density-regulated protein - Bos taurus (Bovine) - DENR gene May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity). Taurus_UMD|evm.model.AC_000186.1.66 P49862 KLK7_HUMAN 58.537 0.731481 0.426877 KLK7 - Kallikrein-7 precursor - Homo sapiens (Human) - KLK7 gene May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. Taurus_UMD|evm.model.AC_000186.1.68 Q96L58 B3GT6_HUMAN 41.600 0.74359 0.474164 B3GALT6 - Beta-1,3-galactosyltransferase 6 - Homo sapiens (Human) - B3GALT6 gene Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues. Taurus_UMD|evm.model.AC_000186.1.70 Q3ZBE6 TM135_BOVIN 96.820 0.824561 0.746725 TMEM135 - Transmembrane protein 135 - Bos taurus (Bovine) - TMEM135 gene Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization. Taurus_UMD|evm.model.AC_000186.1.71 Q9ULV1 FZD4_HUMAN 97.303 0.866221 1.11359 FZD4 - Frizzled-4 precursor - Homo sapiens (Human) - FZD4 gene Receptor for Wnt proteins (PubMed:30135577). Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (PubMed:30135577). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Taurus_UMD|evm.model.AC_000186.1.72 Q1LZE9 PRS23_BOVIN 100.000 0.994681 1.00267 PRSS23 - Serine protease 23 precursor - Bos taurus (Bovine) - PRSS23 gene Taurus_UMD|evm.model.AC_000186.1.73 Q16798 MAON_HUMAN 88.406 0.909574 0.933775 ME3 - NADP-dependent malic enzyme, mitochondrial precursor - Homo sapiens (Human) - ME3 gene mitochondrial matrix, mitochondrion, malate dehydrogenase (decarboxylating) (NADP+) activity, malic enzyme activity, NADP+ binding, aerobic respiration, malate metabolic process, oxygen metabolic process, pyruvate metabolic process, tricarboxylic acid cycle Taurus_UMD|evm.model.AC_000186.1.74 Q78EG7 TP4A1_RAT 87.861 0.988506 1.00578 Ptp4a1 - Protein tyrosine phosphatase type IVA 1 precursor - Rattus norvegicus (Rat) - Ptp4a1 gene Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). Taurus_UMD|evm.model.AC_000186.1.75 Q6ZN84 CCD81_HUMAN 78.378 0.997001 1.02301 CCDC81 - Coiled-coil domain-containing protein 81 - Homo sapiens (Human) - CCDC81 gene centrosome Taurus_UMD|evm.model.AC_000186.1.76 Q56JY0 HIKES_BOVIN 100.000 0.989899 1.00508 HIKESHI - Protein Hikeshi - Bos taurus (Bovine) - HIKESHI gene Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus (By similarity). Taurus_UMD|evm.model.AC_000186.1.77 Q3SZ25 EED_BOVIN 100.000 0.995475 1.00227 EED - Polycomb protein EED - Bos taurus (Bovine) - EED gene Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Taurus_UMD|evm.model.AC_000186.1.78 Q7M6Y3 PICAL_MOUSE 89.448 0.959253 0.892424 Picalm - Phosphatidylinositol-binding clathrin assembly protein - Mus musculus (Mouse) - Picalm gene Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF). Taurus_UMD|evm.model.AC_000186.1.79 Q2TA00 CCD83_BOVIN 100.000 0.995169 1.00242 CCDC83 - Coiled-coil domain-containing protein 83 - Bos taurus (Bovine) - CCDC83 gene Taurus_UMD|evm.model.AC_000186.1.81 A6QP06 SYTL2_BOVIN 99.788 0.997881 1.00106 SYTL2 - Synaptotagmin-like protein 2 - Bos taurus (Bovine) - SYTL2 gene May act as a RAB27A effector protein and play a role in cytotoxic granule exocytosis in lymphocytes. Taurus_UMD|evm.model.AC_000186.1.82 Q29RS0 CCD89_BOVIN 100.000 0.994609 1.0027 CCDC89 - Coiled-coil domain-containing protein 89 - Bos taurus (Bovine) - CCDC89 gene Taurus_UMD|evm.model.AC_000186.1.83 Q9NS37 ZHANG_HUMAN 89.722 0.983516 1.02825 CREBZF - CREB/ATF bZIP transcription factor - Homo sapiens (Human) - CREBZF gene Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. Taurus_UMD|evm.model.AC_000186.1.84 Q32L86 T126A_BOVIN 100.000 0.478049 2.08122 TMEM126A - Transmembrane protein 126A - Bos taurus (Bovine) - TMEM126A gene mitochondrion, mitochondrial respiratory chain complex I assembly Taurus_UMD|evm.model.AC_000186.1.87 Q63622 DLG2_RAT 99.558 0.982533 0.268779 Dlg2 - Disks large homolog 2 - Rattus norvegicus (Rat) - Dlg2 gene Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). Taurus_UMD|evm.model.AC_000186.1.89 Q9GZT6 CC90B_HUMAN 88.085 0.939759 0.980315 CCDC90B - Coiled-coil domain-containing protein 90B, mitochondrial precursor - Homo sapiens (Human) - CCDC90B gene mitochondrion Taurus_UMD|evm.model.AC_000186.1.90 O94913 PCF11_HUMAN 96.279 0.346527 1.59228 PCF11 - Pre-mRNA cleavage complex 2 protein Pcf11 - Homo sapiens (Human) - PCF11 gene Component of pre-mRNA cleavage complex II. Taurus_UMD|evm.model.AC_000186.1.92 Q923S9 RAB30_MOUSE 100.000 0.990196 1.00493 Rab30 - Ras-related protein Rab-30 precursor - Mus musculus (Mouse) - Rab30 gene The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins (By similarity). Taurus_UMD|evm.model.AC_000186.1.93 Q8IXT1 DDIAS_HUMAN 66.963 0.993994 1.001 DDIAS - DNA damage-induced apoptosis suppressor protein - Homo sapiens (Human) - DDIAS gene May be an anti-apoptotic protein involved in DNA repair or cell survival. Taurus_UMD|evm.model.AC_000186.1.94 Q2TA14 PCP_BOVIN 99.599 0.996 1.002 PRCP - Lysosomal Pro-X carboxypeptidase precursor - Bos taurus (Bovine) - PRCP gene Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH (By similarity). Taurus_UMD|evm.model.AC_000186.1.95 A7MB34 F181B_BOVIN 100.000 0.995238 1.00239 FAM181B - Protein FAM181B - Bos taurus (Bovine) - FAM181B gene Taurus_UMD|evm.model.AC_000186.1.96 Q0VCP2 PX11A_BOVIN 97.976 0.991935 1.00405 PEX11A - Peroxisomal membrane protein 11A - Bos taurus (Bovine) - PEX11A gene May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface. Taurus_UMD|evm.model.AC_000186.1.102 P08579 RU2B_HUMAN 92.982 0.941667 0.533333 SNRPB2 - U2 small nuclear ribonucleoprotein B'' - Homo sapiens (Human) - SNRPB2 gene Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128). Taurus_UMD|evm.model.AC_000186.1.103 Q3UHK6 TEN4_MOUSE 92.727 0.867725 0.0682064 Tenm4 - Teneurin-4 - Mus musculus (Mouse) - Tenm4 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer. Taurus_UMD|evm.model.AC_000186.1.104 Q6N022 TEN4_HUMAN 91.104 0.996842 0.914771 TENM4 - Teneurin-4 - Homo sapiens (Human) - TENM4 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). Taurus_UMD|evm.model.AC_000186.1.105 Q96I59 SYNM_HUMAN 93.631 0.397959 0.821803 NARS2 - Probable asparagine--tRNA ligase, mitochondrial precursor - Homo sapiens (Human) - NARS2 gene cytosol, mitochondrion, nucleoplasm, asparagine-tRNA ligase activity, asparaginyl-tRNA aminoacylation Taurus_UMD|evm.model.AC_000186.1.106 Q5NVM8 RNPS1_PONAB 75.000 0.329843 0.62623 RNPS1 - RNA-binding protein with serine-rich domain 1 - Pongo abelii (Sumatran orangutan) - RNPS1 gene Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity). Taurus_UMD|evm.model.AC_000186.1.107 Q9UQC2 GAB2_HUMAN 92.500 0.99688 0.948225 GAB2 - GRB2-associated-binding protein 2 - Homo sapiens (Human) - GAB2 gene Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. Taurus_UMD|evm.model.AC_000186.1.108 Q9P2H5 UBP35_HUMAN 96.989 0.474438 0.960707 USP35 - Ubiquitin carboxyl-terminal hydrolase 35 - Homo sapiens (Human) - USP35 gene cytosol, nucleus, cysteine-type endopeptidase activity, thiol-dependent deubiquitinase, protein deubiquitination Taurus_UMD|evm.model.AC_000186.1.109 Q4G0X4 KCD21_HUMAN 99.615 0.992337 1.00385 KCTD21 - BTB/POZ domain-containing protein KCTD21 - Homo sapiens (Human) - KCTD21 gene Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Taurus_UMD|evm.model.AC_000186.1.110 Q0P5D9 ALG8_BOVIN 99.810 0.996205 1.0019 ALG8 - Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase - Bos taurus (Bovine) - ALG8 gene Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol before it is transferred to the nascent peptide (By similarity). Required for PKD1/Polycystin-1 maturation and localization to the plasma membrane of the primary cilia (By similarity). Taurus_UMD|evm.model.AC_000186.1.111 Q02827 NDUC2_BOVIN 100.000 0.983471 1.00833 NDUFC2 - NADH dehydrogenase [ubiquinone] 1 subunit C2 - Bos taurus (Bovine) - NDUFC2 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000186.1.112 Q62264 THRSP_MOUSE 72.667 0.949045 1.04667 Thrsp - Thyroid hormone-inducible hepatic protein - Mus musculus (Mouse) - Thrsp gene Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB (By similarity). Taurus_UMD|evm.model.AC_000186.1.113 Q9BQ13 KCD14_HUMAN 68.016 0.954918 0.956863 KCTD14 - BTB/POZ domain-containing protein KCTD14 - Homo sapiens (Human) - KCTD14 gene Taurus_UMD|evm.model.AC_000186.1.114 Q96HW7 INT4_HUMAN 96.992 0.997927 1.00208 INTS4 - Integrator complex subunit 4 - Homo sapiens (Human) - INTS4 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). Taurus_UMD|evm.model.AC_000186.1.115 Q32PA8 AAMDC_BOVIN 73.770 0.978022 0.745902 AAMDC - Mth938 domain-containing protein - Bos taurus (Bovine) - AAMDC gene May play a role in preadipocyte differentiation and adipogenesis. Taurus_UMD|evm.model.AC_000186.1.116 Q96T23 RSF1_HUMAN 90.273 0.99021 0.992366 RSF1 - Remodeling and spacing factor 1 - Homo sapiens (Human) - RSF1 gene Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex (PubMed:12972596). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11944984, PubMed:11788598). Taurus_UMD|evm.model.AC_000186.1.117 P35521 ICLN_CANLF 96.624 0.991597 1.01277 CLNS1A - Methylosome subunit pICln - Canis lupus familiaris (Dog) - CLNS1A gene Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway (By similarity). Taurus_UMD|evm.model.AC_000186.1.118 F6S3G9 AQP11_HORSE 86.538 0.830645 0.911765 AQP11 - Aquaporin-11 - Equus caballus (Horse) - AQP11 gene Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (By similarity). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development (By similarity). Taurus_UMD|evm.model.AC_000186.1.119 Q2KID4 DNAL1_BOVIN 86.047 0.977099 0.689474 DNAL1 - Dynein axonemal light chain 1 - Bos taurus (Bovine) - DNAL1 gene Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (By similarity). Taurus_UMD|evm.model.AC_000186.1.120 Q08E52 PAK1_BOVIN 100.000 0.99633 1.00184 PAK1 - Serine/threonine-protein kinase PAK 1 - Bos taurus (Bovine) - PAK1 gene Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus. In podocytes, promotes NR3C2 nuclear localization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation. Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion. In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (By similarity). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (By similarity). Taurus_UMD|evm.model.AC_000186.1.121 Q95JR7 GDPD4_MACFA 68.662 0.605996 0.744817 GDPD4 - Glycerophosphodiester phosphodiesterase domain-containing protein 4 - Macaca fascicularis (Crab-eating macaque) - GDPD4 gene Taurus_UMD|evm.model.AC_000186.1.122 Q6W3E5 GDPD4_HUMAN 61.137 0.37234 0.905297 GDPD4 - Glycerophosphodiester phosphodiesterase domain-containing protein 4 - Homo sapiens (Human) - GDPD4 gene Taurus_UMD|evm.model.AC_000186.1.123 P68101 IF2A_RAT 95.873 0.993443 0.968254 Eif2s1 - Eukaryotic translation initiation factor 2 subunit 1 - Rattus norvegicus (Rat) - Eif2s1 gene Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. EIF2S1/eIF-2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming. Taurus_UMD|evm.model.AC_000186.1.124 O46414 FRIH_BOVIN 94.828 0.919355 0.342541 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000186.1.126 Q86TE4 LUZP2_HUMAN 68.882 0.990798 0.942197 LUZP2 - Leucine zipper protein 2 precursor - Homo sapiens (Human) - LUZP2 gene Taurus_UMD|evm.model.AC_000186.1.128 P00355 G3P_PIG 67.105 0.984314 0.765766 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Sus scrofa (Pig) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Taurus_UMD|evm.model.AC_000186.1.129 Q96EQ9 PRDM9_MOUSE 54.717 0.444444 0.13879 Prdm9 - Histone-lysine N-methyltransferase PRDM9 - Mus musculus (Mouse) - Prdm9 gene Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:16292313, PubMed:24095733, PubMed:27362481, PubMed:24785241, PubMed:29478809). Also can methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24785241, PubMed:27362481). Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (PubMed:24785241, PubMed:27362481). During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:22028627, PubMed:27362481, PubMed:29478809). Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (PubMed:16292313, PubMed:29478809). During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema (PubMed:27932493). EWSR1 joins PRDM9 with the chromosomal axis through REC8 (PubMed:27932493). In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (PubMed:25894966, PubMed:16292313). Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (PubMed:16292313). In addition performs automethylation (PubMed:28126738). Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (PubMed:27362481). Taurus_UMD|evm.model.AC_000186.1.130 H3BU77 CC179_HUMAN 65.217 0.849057 0.779412 CCDC179 - Coiled-coil domain-containing protein 179 - Homo sapiens (Human) - CCDC179 gene Taurus_UMD|evm.model.AC_000186.1.131 O43903 GAS2_HUMAN 98.083 0.993631 1.00319 GAS2 - Growth arrest-specific protein 2 - Homo sapiens (Human) - GAS2 gene May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity). Taurus_UMD|evm.model.AC_000186.1.132 Q9NPI8 FANCF_HUMAN 74.230 0.988889 0.962567 FANCF - Fanconi anemia group F protein - Homo sapiens (Human) - FANCF gene DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity). Taurus_UMD|evm.model.AC_000186.1.133 A6QLI1 VGLU2_BOVIN 92.955 0.99631 0.931271 SLC17A6 - Vesicular glutamate transporter 2 - Bos taurus (Bovine) - SLC17A6 gene Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity). May also mediate the transport of inorganic phosphate (By similarity). Involved in the regulation of retinal hyaloid vessel regression during postnatal development (By similarity). Taurus_UMD|evm.model.AC_000186.1.134 Q75V66 ANO5_HUMAN 81.610 0.798429 1.2552 ANO5 - Anoctamin-5 - Homo sapiens (Human) - ANO5 gene Does not exhibit calcium-activated chloride channel (CaCC) activity. Taurus_UMD|evm.model.AC_000186.1.135 Q92832 NELL1_HUMAN 88.434 0.955202 0.854321 NELL1 - Protein kinase C-binding protein NELL1 precursor - Homo sapiens (Human) - NELL1 gene Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization. Taurus_UMD|evm.model.AC_000186.1.136 Q9Y345 SC6A5_HUMAN 95.570 0.997472 0.992472 SLC6A5 - Sodium- and chloride-dependent glycine transporter 2 - Homo sapiens (Human) - SLC6A5 gene Sodium- and chloride-dependent glycine transporter (PubMed:9845349, PubMed:10381548, PubMed:10606742, PubMed:31370103). Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:9845349). May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses (PubMed:9845349). Taurus_UMD|evm.model.AC_000186.1.137 O60678 ANM3_HUMAN 83.051 0.995851 0.907721 PRMT3 - Protein arginine N-methyltransferase 3 - Homo sapiens (Human) - PRMT3 gene Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins. Taurus_UMD|evm.model.AC_000186.1.138 Q9BUP3 HTAI2_HUMAN 94.215 0.860714 1.15702 HTATIP2 - Oxidoreductase HTATIP2 - Homo sapiens (Human) - HTATIP2 gene Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. Taurus_UMD|evm.model.AC_000186.1.139 Q67ER4 R113A_BOVIN 84.091 0.994318 1.02624 RNF113A - E3 ubiquitin-protein ligase RNF113A - Bos taurus (Bovine) - RNF113A gene Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling. Taurus_UMD|evm.model.AC_000186.1.140 A5PKG8 DBX1_BOVIN 100.000 0.99422 1.0029 DBX1 - Homeobox protein DBX1 - Bos taurus (Bovine) - DBX1 gene Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity). Taurus_UMD|evm.model.AC_000186.1.143 E1BKK0 E2F8_BOVIN 99.660 0.397558 0.851039 E2F8 - Transcription factor E2F8 - Bos taurus (Bovine) - E2F8 gene Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene (By similarity). Taurus_UMD|evm.model.AC_000186.1.144 Q4U0T9 CSRP3_BOVIN 100.000 0.989744 1.00515 CSRP3 - Cysteine and glycine-rich protein 3 - Bos taurus (Bovine) - CSRP3 gene Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly. Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association. In vitro can inhibit PKC/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity). Taurus_UMD|evm.model.AC_000186.1.145 Q4R690 ZDH13_MACFA 87.520 0.996885 1.03215 ZDHHC13 - Palmitoyltransferase ZDHHC13 - Macaca fascicularis (Crab-eating macaque) - ZDHHC13 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport. Taurus_UMD|evm.model.AC_000186.1.146 Q4QXU2 MRGX2_RHIBE 60.790 0.950437 1.03939 MRGPRX2 - Mas-related G-protein coupled receptor member X2 - Rhinopithecus bieti (Black snub-nosed monkey) - MRGPRX2 gene Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction. Taurus_UMD|evm.model.AC_000186.1.148 P35234 PTN5_RAT 94.550 0.350239 2.83198 Ptpn5 - Tyrosine-protein phosphatase non-receptor type 5 - Rattus norvegicus (Rat) - Ptpn5 gene May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. Taurus_UMD|evm.model.AC_000186.1.149 Q3KNY0 IGFN1_MOUSE 33.981 0.559006 0.0565111 Igfn1 - Immunoglobulin-like and fibronectin type III domain-containing protein 1 - Mus musculus (Mouse) - Igfn1 gene nucleus, synapse, Z disc, homophilic cell adhesion via plasma membrane adhesion molecules, retina layer formation, synapse assembly Taurus_UMD|evm.model.AC_000186.1.150 Q3MHQ7 TM86A_BOVIN 97.500 0.991701 1.00417 TMEM86A - Lysoplasmalogenase-like protein TMEM86A - Bos taurus (Bovine) - TMEM86A gene alkenylglycerophosphocholine hydrolase activity, alkenylglycerophosphoethanolamine hydrolase activity Taurus_UMD|evm.model.AC_000186.1.151 Q68D10 SPT2_HUMAN 83.584 0.966276 0.99562 SPTY2D1 - Protein SPT2 homolog - Homo sapiens (Human) - SPTY2D1 gene Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026). Taurus_UMD|evm.model.AC_000186.1.152 Q8IX04 UEVLD_HUMAN 92.569 0.995763 1.00212 UEVLD - Ubiquitin-conjugating enzyme E2 variant 3 - Homo sapiens (Human) - UEVLD gene Possible negative regulator of polyubiquitination. Taurus_UMD|evm.model.AC_000186.1.153 Q99816 TS101_HUMAN 96.986 0.86052 1.08462 TSG101 - Tumor susceptibility gene 101 protein - Homo sapiens (Human) - TSG101 gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). Taurus_UMD|evm.model.AC_000186.1.154 Q9TSX5 LDHC_PIG 91.566 0.993994 1.00301 LDHC - L-lactate dehydrogenase C chain - Sus scrofa (Pig) - LDHC gene Possible role in sperm motility. Taurus_UMD|evm.model.AC_000186.1.155 P19858 LDHA_BOVIN 100.000 0.914365 1.09036 LDHA - L-lactate dehydrogenase A chain - Bos taurus (Bovine) - LDHA gene L-lactate dehydrogenase activity Taurus_UMD|evm.model.AC_000186.1.156 P32780 TF2H1_HUMAN 97.628 0.90264 1.10584 GTF2H1 - General transcription factor IIH subunit 1 - Homo sapiens (Human) - GTF2H1 gene Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Taurus_UMD|evm.model.AC_000186.1.157 Q9UPZ3 HPS5_HUMAN 87.876 0.998232 1.00177 HPS5 - Hermansky-Pudlak syndrome 5 protein - Homo sapiens (Human) - HPS5 gene May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. Taurus_UMD|evm.model.AC_000186.1.158 P42819 SAA_SHEEP 83.929 0.840909 1.17857 SAA1 - Serum amyloid A protein - Ovis aries (Sheep) - SAA1 gene Major acute phase reactant. Apolipoprotein of the HDL complex. Taurus_UMD|evm.model.AC_000186.1.159 P35541 SAA_BOVIN 98.462 0.712707 1.39231 SAA1 - Serum amyloid A protein precursor - Bos taurus (Bovine) - SAA1 gene Major acute phase reactant. Apolipoprotein of the HDL complex. Taurus_UMD|evm.model.AC_000186.1.160 P35541 SAA_BOVIN 100.000 0.826923 1.2 SAA1 - Serum amyloid A protein precursor - Bos taurus (Bovine) - SAA1 gene Major acute phase reactant. Apolipoprotein of the HDL complex. Taurus_UMD|evm.model.AC_000186.1.161 Q4QXU6 MRGX2_HOOHO 69.388 0.262295 0.556231 MRGPRX2 - Mas-related G-protein coupled receptor member X2 - Hoolock hoolock (Western hoolock gibbon) - MRGPRX2 gene Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction. Taurus_UMD|evm.model.AC_000186.1.162 Q32L76 SAA4_BOVIN 100.000 0.984615 1.00775 SAA4 - Serum amyloid A-4 protein precursor - Bos taurus (Bovine) - SAA4 gene Major acute phase reactant. Taurus_UMD|evm.model.AC_000186.1.163 P42819 SAA_SHEEP 84.685 0.833333 1.17857 SAA1 - Serum amyloid A protein - Ovis aries (Sheep) - SAA1 gene Major acute phase reactant. Apolipoprotein of the HDL complex. Taurus_UMD|evm.model.AC_000186.1.164 Q8NGN1 OR6T1_HUMAN 65.672 0.741573 0.551084 OR6T1 - Olfactory receptor 6T1 - Homo sapiens (Human) - OR6T1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000186.1.165 Q8NGN2 O10S1_HUMAN 85.477 0.995851 0.728097 OR10S1 - Olfactory receptor 10S1 - Homo sapiens (Human) - OR10S1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000186.1.166 Q60888 OL149_MOUSE 75.862 0.208955 0.430868 Olfr149 - Olfactory receptor 149 - Mus musculus (Mouse) - Olfr149 gene Odorant receptor. Taurus_UMD|evm.model.AC_000186.1.167 Q8VEY3 OL958_MOUSE 75.000 0.886792 0.169872 Olfr958 - Olfactory receptor 958 - Mus musculus (Mouse) - Olfr958 gene Potential odorant receptor. Taurus_UMD|evm.model.AC_000186.1.168 O00534 VMA5A_HUMAN 70.455 0.996183 1 VWA5A - von Willebrand factor A domain-containing protein 5A - Homo sapiens (Human) - VWA5A gene May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. Taurus_UMD|evm.model.AC_000186.1.169 O15481 MAGB4_HUMAN 55.556 0.235869 4.14162 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000186.1.172 Q6IF36 O8G2P_HUMAN 81.915 0.781513 0.391447 OR8G2P - Putative olfactory receptor 8G2 - Homo sapiens (Human) - OR8G2P gene Odorant receptor. Taurus_UMD|evm.model.AC_000186.1.173 Q32KQ5 TM225_BOVIN 99.134 0.991379 1.00433 TMEM225 - Transmembrane protein 225 - Bos taurus (Bovine) - TMEM225 gene Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC. Taurus_UMD|evm.model.AC_000186.1.174 Q6IF36 O8G2P_HUMAN 81.915 0.781513 0.391447 OR8G2P - Putative olfactory receptor 8G2 - Homo sapiens (Human) - OR8G2P gene Odorant receptor. Taurus_UMD|evm.model.AC_000186.1.176 Q8NGG8 OR8B3_HUMAN 74.634 0.995122 0.654952 OR8B3 - Olfactory receptor 8B3 - Homo sapiens (Human) - OR8B3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000186.1.177 Q8NGG8 OR8B3_HUMAN 86.121 0.972222 0.920128 OR8B3 - Olfactory receptor 8B3 - Homo sapiens (Human) - OR8B3 gene Odorant receptor. Taurus_UMD|evm.model.AC_000186.1.178 Q01105 SET_HUMAN 73.222 0.78 0.862069 SET - Protein SET - Homo sapiens (Human) - SET gene Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. Taurus_UMD|evm.model.AC_000186.1.179 Q96RC9 OR8B4_HUMAN 84.142 0.993548 1.00324 OR8B4 - Olfactory receptor 8B4 - Homo sapiens (Human) - OR8B4 gene Odorant receptor. Taurus_UMD|evm.model.AC_000186.1.180 Q96QZ0 PANX3_HUMAN 91.071 0.994911 1.00255 PANX3 - Pannexin-3 - Homo sapiens (Human) - PANX3 gene Structural component of the gap junctions and the hemichannels. Taurus_UMD|evm.model.AC_000186.1.181 Q3YBR2 TBRG1_HUMAN 88.321 0.995146 1.00243 TBRG1 - Transforming growth factor beta regulator 1 - Homo sapiens (Human) - TBRG1 gene Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. Taurus_UMD|evm.model.AC_000186.1.182 Q9HAT2 SIAE_HUMAN 77.438 0.996176 1 SIAE - Sialate O-acetylesterase precursor - Homo sapiens (Human) - SIAE gene Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid. Taurus_UMD|evm.model.AC_000186.1.183 Q62252 SP17_MOUSE 79.137 0.905405 0.993289 Spa17 - Sperm surface protein Sp17 - Mus musculus (Mouse) - Spa17 gene Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity). Taurus_UMD|evm.model.AC_000186.1.184 P54877 NEUG_CAPHI 98.649 0.820225 1.14103 NRGN - Neurogranin - Capra hircus (Goat) - NRGN gene Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). Taurus_UMD|evm.model.AC_000186.1.185 Q96IQ7 VSIG2_HUMAN 84.691 0.474339 1.96636 VSIG2 - V-set and immunoglobulin domain-containing protein 2 precursor - Homo sapiens (Human) - VSIG2 gene integral component of plasma membrane, membrane Taurus_UMD|evm.model.AC_000186.1.186 Q6P1R3 MSD2_HUMAN 99.415 0.307414 0.989267 MSANTD2 - Myb/SANT-like DNA-binding domain-containing protein 2 - Homo sapiens (Human) - MSANTD2 gene Taurus_UMD|evm.model.AC_000186.1.187 Q96MS0 ROBO3_HUMAN 88.905 0.998557 1 ROBO3 - Roundabout homolog 3 precursor - Homo sapiens (Human) - ROBO3 gene Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube (By similarity). In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity). Required for hindbrain axon midline crossing (PubMed:15105459). Taurus_UMD|evm.model.AC_000186.1.188 Q8WZ75 ROBO4_HUMAN 84.082 0.974104 0.997021 ROBO4 - Roundabout homolog 4 precursor - Homo sapiens (Human) - ROBO4 gene Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). Taurus_UMD|evm.model.AC_000186.1.189 A4FUY1 HECAM_BOVIN 100.000 0.995227 1.00239 HEPACAM - Hepatocyte cell adhesion molecule precursor - Bos taurus (Bovine) - HEPACAM gene Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000186.1.190 Q0P6D6 CCD15_HUMAN 59.879 0.613848 0.789695 CCDC15 - Coiled-coil domain-containing protein 15 - Homo sapiens (Human) - CCDC15 gene centrosome Taurus_UMD|evm.model.AC_000186.1.191 Q58CV5 G6PT3_BOVIN 98.004 0.996016 1.0224 SLC37A2 - Glucose-6-phosphate exchanger SLC37A2 - Bos taurus (Bovine) - SLC37A2 gene Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. Taurus_UMD|evm.model.AC_000186.1.192 A5PJF4 TM218_BOVIN 100.000 0.982759 1.0087 TMEM218 - Transmembrane protein 218 - Bos taurus (Bovine) - TMEM218 gene May be involved in ciliary biogenesis or function. Taurus_UMD|evm.model.AC_000186.1.195 Q96KN3 PKNX2_HUMAN 93.008 0.995556 0.95339 PKNOX2 - Homeobox protein PKNOX2 - Homo sapiens (Human) - PKNOX2 gene intercellular bridge, nucleoplasm, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000186.1.196 Q99689 FEZ1_HUMAN 96.939 0.994911 1.00255 FEZ1 - Fasciculation and elongation protein zeta-1 - Homo sapiens (Human) - FEZ1 gene May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. Taurus_UMD|evm.model.AC_000186.1.197 Q08DE5 EI24_BOVIN 99.706 0.994135 1.00294 EI24 - Etoposide-induced protein 2.4 homolog - Bos taurus (Bovine) - EI24 gene Taurus_UMD|evm.model.AC_000186.1.198 Q2KJI2 STT3A_BOVIN 100.000 0.997167 1.00142 STT3A - Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A - Bos taurus (Bovine) - STT3A gene Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A (By similarity). Taurus_UMD|evm.model.AC_000186.1.199 O14757 CHK1_HUMAN 95.588 0.70059 1.42437 CHEK1 - Serine/threonine-protein kinase Chk1 - Homo sapiens (Human) - CHEK1 gene Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). Recognizes the substrate consensus sequence [R-X-X-S/T] (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:9278511, PubMed:12676583, PubMed:14681206, PubMed:12676925, PubMed:12759351, PubMed:19734889, PubMed:14559997). Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C (PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A (PubMed:9278511, PubMed:12676583, PubMed:14681206, PubMed:12676925, PubMed:12759351, PubMed:19734889). Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A (PubMed:9278511, PubMed:19734889, PubMed:20090422). Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression (PubMed:9278511). Also phosphorylates NEK6 (PubMed:18728393). Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination (PubMed:15665856). Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation (PubMed:10673501, PubMed:15659650, PubMed:16511572). Also promotes repair of DNA cross-links through phosphorylation of FANCE (PubMed:17296736). Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A (PubMed:12660173, PubMed:12955071). This may enhance chromatin assembly both in the presence or absence of DNA damage (PubMed:12660173, PubMed:12955071). May also play a role in replication fork maintenance through regulation of PCNA (PubMed:18451105). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones (By similarity). Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (By similarity). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest (PubMed:17380128). Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (PubMed:31316063). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (PubMed:33108758). Taurus_UMD|evm.model.AC_000186.1.200 P26436 ASPX_HUMAN 64.000 0.992701 1.03396 ACRV1 - Acrosomal protein SP-10 precursor - Homo sapiens (Human) - ACRV1 gene multicellular organism development Taurus_UMD|evm.model.AC_000186.1.202 P53353 ASPX_VULVU 30.208 0.824561 0.326648 Sperm acrosomal protein FSA-ACR.1 precursor - Vulpes vulpes (Red fox) Taurus_UMD|evm.model.AC_000186.1.203 D3YWX3 PAT13_MOUSE 42.063 0.937008 0.927007 Pate13 - Prostate and testis expressed protein 13 precursor - Mus musculus (Mouse) - Pate13 gene Taurus_UMD|evm.model.AC_000186.1.204 Q3SX07 PUS3_BOVIN 99.792 0.995851 1.00208 PUS3 - tRNA pseudouridine(38/39) synthase - Bos taurus (Bovine) - PUS3 gene Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs. Taurus_UMD|evm.model.AC_000186.1.205 Q2KI52 HYLS1_BOVIN 100.000 0.993651 1.00318 HYLS1 - Hydrolethalus syndrome protein 1 homolog - Bos taurus (Bovine) - HYLS1 gene Plays a role in ciliogenesis. Taurus_UMD|evm.model.AC_000186.1.206 Q2TBP1 DDX25_BOVIN 99.174 0.995876 1.00414 DDX25 - ATP-dependent RNA helicase DDX25 - Bos taurus (Bovine) - DDX25 gene ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity). Taurus_UMD|evm.model.AC_000186.1.207 P0DP72 VSXL2_HUMAN 76.662 0.918269 1.08475 VSIG10L2 - V-set and immunoglobulin domain-containing protein 10-like 2 precursor - Homo sapiens (Human) - VSIG10L2 gene cell-cell junction, integral component of plasma membrane, cell adhesion molecule binding, cell-cell adhesion Taurus_UMD|evm.model.AC_000186.1.208 Q4KMG0 CDON_HUMAN 80.886 0.998397 0.969697 CDON - Cell adhesion molecule-related/down-regulated by oncogenes precursor - Homo sapiens (Human) - CDON gene Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity). Taurus_UMD|evm.model.AC_000186.1.209 Q5E9Z1 RUSD4_BOVIN 99.469 0.994709 1.00265 RPUSD4 - Mitochondrial RNA pseudouridine synthase RPUSD4 precursor - Bos taurus (Bovine) - RPUSD4 gene Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. Acts on position 39 in mitochondrial tRNA(Phe). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Taurus_UMD|evm.model.AC_000186.1.210 Q4R836 F118B_MACFA 98.230 0.7 0.457143 FAM118B - Protein FAM118B - Macaca fascicularis (Crab-eating macaque) - FAM118B gene May play a role in Cajal bodies formation. Taurus_UMD|evm.model.AC_000186.1.211 Q4R836 F118B_MACFA 100.000 0.262255 2.33143 FAM118B - Protein FAM118B - Macaca fascicularis (Crab-eating macaque) - FAM118B gene May play a role in Cajal bodies formation. Taurus_UMD|evm.model.AC_000186.1.212 Q5EA45 FXRD1_BOVIN 100.000 0.995893 1.00206 FOXRED1 - FAD-dependent oxidoreductase domain-containing protein 1 - Bos taurus (Bovine) - FOXRED1 gene Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly. Taurus_UMD|evm.model.AC_000186.1.213 P58753 TIRAP_HUMAN 77.056 0.987124 1.0543 TIRAP - Toll/interleukin-1 receptor domain-containing adapter protein - Homo sapiens (Human) - TIRAP gene Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. Taurus_UMD|evm.model.AC_000186.1.214 O46415 FRIL_BOVIN 74.766 0.981481 0.617143 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000186.1.215 Q8MJJ7 DCPS_BOVIN 99.407 0.994083 1.00297 DCPS - m7GpppX diphosphatase - Bos taurus (Bovine) - DCPS gene Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death. Taurus_UMD|evm.model.AC_000186.1.216 Q11206 SIA4C_HUMAN 89.189 0.932584 1.06907 ST3GAL4 - CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 - Homo sapiens (Human) - ST3GAL4 gene A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:8288606, PubMed:8611500). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8288606, PubMed:8611500). Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (By similarity). Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation (PubMed:25498912). Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (By similarity). In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (PubMed:8288606). Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity). Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (PubMed:8611500). Taurus_UMD|evm.model.AC_000186.1.217 Q8IZU9 KIRR3_HUMAN 98.419 0.997368 0.976864 KIRREL3 - Kin of IRRE-like protein 3 precursor - Homo sapiens (Human) - KIRREL3 gene Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells. Taurus_UMD|evm.model.AC_000186.1.222 P41156 ETS1_RAT 98.551 0.849794 1.10204 Ets1 - Protein C-ets-1 - Rattus norvegicus (Rat) - Ets1 gene Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (By similarity). Taurus_UMD|evm.model.AC_000186.1.225 Q29RS8 FLI1_BOVIN 99.776 0.95914 1.02876 FLI1 - Friend leukemia integration 1 transcription factor - Bos taurus (Bovine) - FLI1 gene Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3' (By similarity). Taurus_UMD|evm.model.AC_000186.1.226 P48048 KCNJ1_HUMAN 95.430 0.994638 0.953964 KCNJ1 - ATP-sensitive inward rectifier potassium channel 1 - Homo sapiens (Human) - KCNJ1 gene In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. Taurus_UMD|evm.model.AC_000186.1.227 F1MYR9 KCNJ5_BOVIN 100.000 0.995238 1.00239 KCNJ5 - G protein-activated inward rectifier potassium channel 4 - Bos taurus (Bovine) - KCNJ5 gene This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.Can be blocked by external barium. Taurus_UMD|evm.model.AC_000186.1.229 Q5RFJ2 1433T_PONAB 91.837 0.991803 0.995918 YWHAQ - 14-3-3 protein theta - Pongo abelii (Sumatran orangutan) - YWHAQ gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). Taurus_UMD|evm.model.AC_000186.1.230 A7KAX9 RHG32_HUMAN 80.611 0.979914 1.00192 ARHGAP32 - Rho GTPase-activating protein 32 - Homo sapiens (Human) - ARHGAP32 gene GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). Taurus_UMD|evm.model.AC_000186.1.232 Q9UMQ3 BARX2_HUMAN 100.000 0.579439 0.383513 BARX2 - Homeobox protein BarH-like 2 - Homo sapiens (Human) - BARX2 gene Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity). Taurus_UMD|evm.model.AC_000186.1.234 Q9N0M2 BARX2_SHEEP 94.697 0.577093 1.70677 BARX2 - Homeobox protein BarH-like 2 - Ovis aries (Sheep) - BARX2 gene Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia. Taurus_UMD|evm.model.AC_000186.1.235 P51813 BMX_HUMAN 75.439 0.364238 0.223704 BMX - Cytoplasmic tyrosine-protein kinase BMX - Homo sapiens (Human) - BMX gene Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. Taurus_UMD|evm.model.AC_000186.1.236 Q9BX67 JAM3_HUMAN 84.839 0.875 1.10968 JAM3 - Junctional adhesion molecule C precursor - Homo sapiens (Human) - JAM3 gene Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed:11590146, PubMed:11823489). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:12208882, PubMed:15194813). Plays a role in angiogenesis (PubMed:23255084). Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion (By similarity). Taurus_UMD|evm.model.AC_000186.1.237 Q9UPX0 TUTLB_HUMAN 92.995 0.882433 1.08451 IGSF9B - Protein turtle homolog B precursor - Homo sapiens (Human) - IGSF9B gene Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion. Taurus_UMD|evm.model.AC_000186.1.238 Q3SZQ3 SPT19_BOVIN 100.000 0.987097 1.00649 SPATA19 - Spermatogenesis-associated protein 19, mitochondrial precursor - Bos taurus (Bovine) - SPATA19 gene May have a role in spermiogenesis. Taurus_UMD|evm.model.AC_000186.1.244 P11834 OPCM_BOVIN 100.000 0.545455 0.286957 OPCML - Opioid-binding protein/cell adhesion molecule precursor - Bos taurus (Bovine) - OPCML gene Binds opioids in the presence of acidic lipids; probably involved in cell contact. Taurus_UMD|evm.model.AC_000186.1.245 Q5IS61 OPCM_PANTR 100.000 0.554745 0.397101 OPCML - Opioid-binding protein/cell adhesion molecule precursor - Pan troglodytes (Chimpanzee) - OPCML gene Binds opioids in the presence of acidic lipids; probably involved in cell contact. Taurus_UMD|evm.model.AC_000186.1.247 Q6WV90 H4_MYTGA 99.029 0.980769 1.00971 Histone H4 - Mytilus galloprovincialis (Mediterranean mussel) Taurus_UMD|evm.model.AC_000186.1.248 P11834 OPCM_BOVIN 95.000 0.913265 0.568116 OPCML - Opioid-binding protein/cell adhesion molecule precursor - Bos taurus (Bovine) - OPCML gene Binds opioids in the presence of acidic lipids; probably involved in cell contact. Taurus_UMD|evm.model.AC_000186.1.249 Q58DA5 NTRI_BOVIN 93.750 0.99458 1.06957 NTM - Neurotrimin precursor - Bos taurus (Bovine) - NTM gene Neural cell adhesion molecule. Taurus_UMD|evm.model.AC_000186.1.252 Q3T130 TM45B_BOVIN 100.000 0.99278 1.00362 TMEM45B - Transmembrane protein 45B - Bos taurus (Bovine) - TMEM45B gene Taurus_UMD|evm.model.AC_000186.1.253 Q6P4R8 NFRKB_HUMAN 92.379 0.998452 0.994611 NFRKB - Nuclear factor related to kappa-B-binding protein - Homo sapiens (Human) - NFRKB gene Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. Taurus_UMD|evm.model.AC_000186.1.254 Q9NQV6 PRD10_HUMAN 91.983 0.998262 1.00349 PRDM10 - PR domain zinc finger protein 10 - Homo sapiens (Human) - PRDM10 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000186.1.255 Q8NDX6 ZN740_HUMAN 98.446 0.989691 1.00518 ZNF740 - Zinc finger protein 740 - Homo sapiens (Human) - ZNF740 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000186.1.257 Q06335 APLP2_MOUSE 91.500 0.511905 1.06931 Aplp2 - Amyloid-like protein 2 precursor - Mus musculus (Mouse) - Aplp2 gene May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein (By similarity). Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts. Taurus_UMD|evm.model.AC_000186.1.258 Q0IIH7 ST14_BOVIN 79.062 0.997465 0.922807 ST14 - Suppressor of tumorigenicity 14 protein homolog - Bos taurus (Bovine) - ST14 gene Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (By similarity). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (By similarity). Taurus_UMD|evm.model.AC_000186.1.259 Q8NCP5 ZBT44_HUMAN 96.814 0.915584 1.0807 ZBTB44 - Zinc finger and BTB domain-containing protein 44 - Homo sapiens (Human) - ZBTB44 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000186.1.261 Q9UP79 ATS8_HUMAN 75.666 0.955556 1.01237 ADAMTS8 - A disintegrin and metalloproteinase with thrombospondin motifs 8 precursor - Homo sapiens (Human) - ADAMTS8 gene Has anti-angiogenic properties. Taurus_UMD|evm.model.AC_000186.1.262 Q8TE58 ATS15_HUMAN 91.684 0.997872 0.989474 ADAMTS15 - A disintegrin and metalloproteinase with thrombospondin motifs 15 precursor - Homo sapiens (Human) - ADAMTS15 gene Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration. Taurus_UMD|evm.model.AC_000186.1.263 Q92543 SNX19_HUMAN 80.665 0.982018 1.00907 SNX19 - Sorting nexin-19 - Homo sapiens (Human) - SNX19 gene Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion (PubMed:24843546). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). Taurus_UMD|evm.model.AC_000186.1.265 P27213 PTPS_RAT 89.844 0.518367 1.70139 Pts - 6-pyruvoyl tetrahydrobiopterin synthase precursor - Rattus norvegicus (Rat) - Pts gene Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. Taurus_UMD|evm.model.AC_000186.1.266 Q99N10 M4A8_MOUSE 61.753 0.991903 0.851724 Ms4a8 - Membrane-spanning 4-domains subfamily A member 8 - Mus musculus (Mouse) - Ms4a8 gene May be involved in signal transduction as a component of a multimeric receptor complex. Taurus_UMD|evm.model.AC_000186.1.267 A6QPF4 M4A18_BOVIN 100.000 0.994083 1.00297 MS4A18 - Membrane-spanning 4-domains subfamily A member 18 - Bos taurus (Bovine) - MS4A18 gene Taurus_UMD|evm.model.AC_000186.1.268 Q3UPL6 M4A15_MOUSE 89.520 0.938272 0.991837 Ms4a15 - Membrane-spanning 4-domains subfamily A member 15 - Mus musculus (Mouse) - Ms4a15 gene May be involved in signal transduction as a component of a multimeric receptor complex. Taurus_UMD|evm.model.AC_000186.1.269 Q96PG2 M4A10_HUMAN 60.000 0.96748 0.921348 MS4A10 - Membrane-spanning 4-domains subfamily A member 10 - Homo sapiens (Human) - MS4A10 gene May be involved in signal transduction as a component of a multimeric receptor complex. Taurus_UMD|evm.model.AC_000186.1.270 Q2TBX7 CCD86_BOVIN 99.435 0.994366 1.00282 CCDC86 - Coiled-coil domain-containing protein 86 - Bos taurus (Bovine) - CCDC86 gene Taurus_UMD|evm.model.AC_000186.1.271 Q9Y5Y4 PD2R2_HUMAN 80.732 0.992629 1.03038 PTGDR2 - Prostaglandin D2 receptor 2 - Homo sapiens (Human) - PTGDR2 gene Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. Taurus_UMD|evm.model.AC_000186.1.272 Q08E38 PRP19_BOVIN 100.000 0.99604 1.00198 PRPF19 - Pre-mRNA-processing factor 19 - Bos taurus (Bovine) - PRPF19 gene Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries. The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair. Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response. May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA. As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process. In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (By similarity). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity). Taurus_UMD|evm.model.AC_000186.1.273 O77751 TM109_RABIT 84.774 0.991803 1.00412 TMEM109 - Transmembrane protein 109 precursor - Oryctolagus cuniculus (Rabbit) - TMEM109 gene May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (By similarity). Can form voltage-gated calcium and potassium channels in vitro (PubMed:21381722). Taurus_UMD|evm.model.AC_000186.1.274 Q24JP5 T132A_HUMAN 89.428 0.998062 1.0088 TMEM132A - Transmembrane protein 132A precursor - Homo sapiens (Human) - TMEM132A gene May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity). Taurus_UMD|evm.model.AC_000186.1.275 Q8IY34 S15A3_HUMAN 82.444 0.996564 1.00172 SLC15A3 - Solute carrier family 15 member 3 - Homo sapiens (Human) - SLC15A3 gene Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity). Taurus_UMD|evm.model.AC_000186.1.276 P30203 CD6_HUMAN 71.875 0.991137 1.01347 CD6 - T-cell differentiation antigen CD6 precursor - Homo sapiens (Human) - CD6 gene Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777). Taurus_UMD|evm.model.AC_000186.1.277 P19238 CD5_BOVIN 100.000 0.995968 1.00202 CD5 - T-cell surface glycoprotein CD5 precursor - Bos taurus (Bovine) - CD5 gene May act as a receptor in regulating T-cell proliferation. Taurus_UMD|evm.model.AC_000186.1.278 A5D8V6 VP37C_HUMAN 83.537 0.862434 1.06479 VPS37C - Vacuolar protein sorting-associated protein 37C - Homo sapiens (Human) - VPS37C gene Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Taurus_UMD|evm.model.AC_000186.1.279 P83493 PAG6_SHEEP 73.529 0.55 0.157895 Pregnancy-associated glycoprotein 6 precursor - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000186.1.280 Q29432 PAG1_BOVIN 81.768 0.99449 0.955263 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.282 Q29432 PAG1_BOVIN 77.955 0.996805 0.823684 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.283 Q29432 PAG1_BOVIN 81.768 0.99449 0.955263 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.284 P83495 PAG4_SHEEP 80.315 0.984375 0.336842 Pregnancy-associated glycoprotein 4 precursor - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000186.1.285 Q29432 PAG1_BOVIN 85.057 0.945055 0.239474 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.286 Q29432 PAG1_BOVIN 80.663 0.99449 0.955263 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.287 Q29432 PAG1_BOVIN 80.511 0.996805 0.823684 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.288 P61570 ENK25_HUMAN 33.962 0.989744 0.295008 ERVK-25 - Endogenous retrovirus group K member 25 Env polyprotein precursor - Homo sapiens (Human) - ERVK-25 gene Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity). Taurus_UMD|evm.model.AC_000186.1.289 Q29432 PAG1_BOVIN 100.000 0.99449 0.955263 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.290 Q29432 PAG1_BOVIN 81.150 0.996805 0.823684 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.292 Q29432 PAG1_BOVIN 73.684 0.982456 0.15 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.293 Q29432 PAG1_BOVIN 82.748 0.996805 0.823684 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.294 Q29432 PAG1_BOVIN 69.822 0.986622 0.786842 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.295 Q29432 PAG1_BOVIN 78.594 0.996805 0.823684 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.296 P79110 TXTP_BOVIN 96.610 0.783784 0.237942 SLC25A1 - Tricarboxylate transport protein, mitochondrial precursor - Bos taurus (Bovine) - SLC25A1 gene Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Taurus_UMD|evm.model.AC_000186.1.297 Q2KIV1 S22A9_BOVIN 98.758 0.993808 0.585145 SLC22A9 - Solute carrier family 22 member 9 - Bos taurus (Bovine) - SLC22A9 gene Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes (By similarity). Taurus_UMD|evm.model.AC_000186.1.298 Q29432 PAG1_BOVIN 78.158 0.994737 1 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.299 Q2KIV1 S22A9_BOVIN 74.229 0.994575 1.00181 SLC22A9 - Solute carrier family 22 member 9 - Bos taurus (Bovine) - SLC22A9 gene Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes (By similarity). Taurus_UMD|evm.model.AC_000186.1.300 Q4KLN5 PLAT5_RAT 94.702 0.892857 0.585366 Plaat5 - Phospholipase A and acyltransferase 5 - Rattus norvegicus (Rat) - Plaat5 gene Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:17158102). Taurus_UMD|evm.model.AC_000186.1.301 Q29432 PAG1_BOVIN 80.874 0.973262 0.492105 Pregnancy-associated glycoprotein 1 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.302 P0DP31 CALM3_RAT 98.658 0.986667 1.00671 Calm3 - Calmodulin-3 - Rattus norvegicus (Rat) - Calm3 gene Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Taurus_UMD|evm.model.AC_000186.1.303 P00792 PEPA_BOVIN 98.925 0.994638 1.00269 PGA - Pepsin A precursor - Bos taurus (Bovine) - PGA gene Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. Taurus_UMD|evm.model.AC_000186.1.304 Q96DN2 VWCE_HUMAN 88.101 0.913853 0.899476 VWCE - von Willebrand factor C and EGF domain-containing protein precursor - Homo sapiens (Human) - VWCE gene May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma. Taurus_UMD|evm.model.AC_000186.1.305 A1A4K3 DDB1_BOVIN 99.563 0.998252 1.00351 DDB1 - DNA damage-binding protein 1 - Bos taurus (Bovine) - DDB1 gene Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (By similarity). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity). Taurus_UMD|evm.model.AC_000186.1.306 Q58DK4 TKFC_BOVIN 99.481 0.996546 1.00173 TKFC - Triokinase/FMN cyclase - Bos taurus (Bovine) - TKFC gene Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response. Taurus_UMD|evm.model.AC_000186.1.307 A5D9A7 CYAC3_BOVIN 100.000 0.847826 1.04151 CYB561A3 - Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 - Bos taurus (Bovine) - CYB561A3 gene Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most problably involved in endosomal and lysosomal cellular iron homeostasis. Taurus_UMD|evm.model.AC_000186.1.309 A5PJY4 TM138_BOVIN 100.000 0.436314 2.27778 TMEM138 - Transmembrane protein 138 - Bos taurus (Bovine) - TMEM138 gene Required for ciliogenesis. Taurus_UMD|evm.model.AC_000186.1.310 Q8N684 CPSF7_HUMAN 99.788 0.94 1.06157 CPSF7 - Cleavage and polyadenylation specificity factor subunit 7 - Homo sapiens (Human) - CPSF7 gene Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:8626397, PubMed:17024186, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:8626397, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:8626397, PubMed:17024186). Taurus_UMD|evm.model.AC_000186.1.311 Q3ZBC2 SDHF2_BOVIN 100.000 0.988024 1.00602 SDHAF2 - Succinate dehydrogenase assembly factor 2, mitochondrial precursor - Bos taurus (Bovine) - SDHAF2 gene Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. Taurus_UMD|evm.model.AC_000186.1.312 Q2T9T0 PPR32_BOVIN 99.533 0.995338 1.00234 PPP1R32 - Protein phosphatase 1 regulatory subunit 32 - Bos taurus (Bovine) - PPP1R32 gene phosphatase binding Taurus_UMD|evm.model.AC_000186.1.313 A6NIK2 LR10B_HUMAN 96.575 0.993174 1.00342 LRRC10B - Leucine-rich repeat-containing protein 10B - Homo sapiens (Human) - LRRC10B gene Taurus_UMD|evm.model.AC_000186.1.314 O43581 SYT7_HUMAN 95.157 0.531394 1.62035 SYT7 - Synaptotagmin-7 - Homo sapiens (Human) - SYT7 gene Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity). Taurus_UMD|evm.model.AC_000186.1.316 Q9Y4D2 DGLA_HUMAN 97.699 0.998081 1 DAGLA - Diacylglycerol lipase-alpha - Homo sapiens (Human) - DAGLA gene Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:26668358, PubMed:23502535). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:26668358, PubMed:23502535). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). Taurus_UMD|evm.model.AC_000186.1.317 Q9Y2G1 MYRF_HUMAN 91.900 0.98709 0.874891 MYRF - Myelin regulatory factor - Homo sapiens (Human) - MYRF gene Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832). Taurus_UMD|evm.model.AC_000186.1.318 Q3UR85 MYRF_MOUSE 87.302 0.984252 0.111599 Myrf - Myelin regulatory factor - Mus musculus (Mouse) - Myrf gene Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. Taurus_UMD|evm.model.AC_000186.1.320 Q32P84 TM258_BOVIN 100.000 0.973333 0.949367 TMEM258 - Transmembrane protein 258 - Bos taurus (Bovine) - TMEM258 gene Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Involved in ER homeostasis in the colonic epithelium (By similarity). Taurus_UMD|evm.model.AC_000186.1.321 Q58DH8 FEN1_BOVIN 100.000 0.994751 1.00263 FEN1 - Flap endonuclease 1 - Bos taurus (Bovine) - FEN1 gene Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. Taurus_UMD|evm.model.AC_000186.1.322 O60427 FADS1_HUMAN 93.636 0.995465 0.993243 FADS1 - Acyl-CoA (8-3)-desaturase - Homo sapiens (Human) - FADS1 gene Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (PubMed:10601301, PubMed:10769175). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity). Taurus_UMD|evm.model.AC_000186.1.323 Q8IXX5 T183A_HUMAN 75.472 0.385185 0.359043 TMEM183A - Transmembrane protein 183A - Homo sapiens (Human) - TMEM183A gene Taurus_UMD|evm.model.AC_000186.1.324 A4FV48 FADS2_BOVIN 100.000 0.995506 1.00225 FADS2 - Acyl-CoA 6-desaturase - Bos taurus (Bovine) - FADS2 gene Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). It can also desaturate (11E)-octadecenoate (trans-vaccenoate, a metabolite in the biohydrogenation pathway of LA and the predominant trans fatty acid in cow milk) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity). Taurus_UMD|evm.model.AC_000186.1.325 A4IFP3 FADS3_BOVIN 100.000 0.995495 1.00226 FADS3 - Fatty acid desaturase 3 - Bos taurus (Bovine) - FADS3 gene Mammals have different sphingoid bases that differ in their length and/or pattern of desaturation and hydroxyl groups. The predominant sphingoid base in mammalian ceramides is sphing-4-enine (sphingosine or SPH) which has a trans desaturation at carbon 4. FADS3 is a ceramide desaturase that introduces a cis double bond between carbon 14 and carbon 15 of the SPH-containing ceramides, producing sphinga-4,14-dienine-containing ceramides (SPD ceramides). SPD ceramides occur widely in mammalian tissues and cells. Due to their unusual structure containing a cis double bond, SPD ceramides may have an opposite, negative role in lipid microdomain formation relative to conventional ceramides (By similarity). FADS3 also acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturates (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in cow milk) at carbon 13 to generate (11E,13Z)-octadecadienoate (also known as conjugated linoleic acid 11E,13Z-CLA), likely participating in the biohydrogenation pathway of linoleic acid (LA) (By similarity). Taurus_UMD|evm.model.AC_000186.1.326 Q2KJ58 R3GEF_BOVIN 100.000 0.878995 1.12308 RAB3IL1 - Guanine nucleotide exchange factor for Rab-3A - Bos taurus (Bovine) - RAB3IL1 gene Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B (By similarity). Taurus_UMD|evm.model.AC_000186.1.327 Q8WMR7 BEST1_PIG 83.565 0.735495 1.36916 BEST1 - Bestrophin-1 - Sus scrofa (Pig) - BEST1 gene Forms calcium-sensitive chloride channels. Permeable to bicarbonate (By similarity). Taurus_UMD|evm.model.AC_000186.1.328 O46414 FRIH_BOVIN 98.438 0.913669 0.767956 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000186.1.329 Q9NQS7 INCE_HUMAN 73.218 0.99652 0.938998 INCENP - Inner centromere protein - Homo sapiens (Human) - INCENP gene Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). Taurus_UMD|evm.model.AC_000186.1.330 A0JNP2 SG1D_BOVIN 96.429 0.410891 1.98039 SCGB1D - Secretoglobin family 1D member precursor - Bos taurus (Bovine) - SCGB1D gene May bind androgens and other steroids. May be under transcriptional regulation of steroid hormones (By similarity). Taurus_UMD|evm.model.AC_000186.1.332 Q32LE5 ASGL1_BOVIN 100.000 0.916418 1.08766 ASRGL1 - Isoaspartyl peptidase/L-asparaginase precursor - Bos taurus (Bovine) - ASRGL1 gene Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. Taurus_UMD|evm.model.AC_000186.1.333 Q2VPS3 UTER_BOVIN 98.901 0.978261 1.01099 SCGB1A1 - Uteroglobin precursor - Bos taurus (Bovine) - SCGB1A1 gene Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. Taurus_UMD|evm.model.AC_000186.1.334 Q09666 AHNK_HUMAN 64.170 0.960757 0.744143 AHNAK - Neuroblast differentiation-associated protein AHNAK - Homo sapiens (Human) - AHNAK gene May be required for neuronal cell differentiation. Taurus_UMD|evm.model.AC_000186.1.335 Q3SZV3 EF1G_BOVIN 99.773 0.995465 1.00227 EEF1G - Elongation factor 1-gamma - Bos taurus (Bovine) - EEF1G gene Probably plays a role in anchoring the complex to other cellular components. Taurus_UMD|evm.model.AC_000186.1.336 Q1JPD6 STPAP_BOVIN 99.770 0.997706 1.00115 TUT1 - Speckle targeted PIP5K1A-regulated poly(A) polymerase - Bos taurus (Bovine) - TUT1 gene Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation. Taurus_UMD|evm.model.AC_000186.1.337 Q9R190 MTA2_MOUSE 98.353 0.997001 0.998503 Mta2 - Metastasis-associated protein MTA2 - Mus musculus (Mouse) - Mta2 gene May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins. Taurus_UMD|evm.model.AC_000186.1.338 Q32P44 EMAL3_HUMAN 93.192 0.997768 1 EML3 - Echinoderm microtubule-associated protein-like 3 - Homo sapiens (Human) - EML3 gene Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). Taurus_UMD|evm.model.AC_000186.1.339 P52205 ROM1_BOVIN 100.000 0.994318 1.00285 ROM1 - Rod outer segment membrane protein 1 - Bos taurus (Bovine) - ROM1 gene Plays a role in rod outer segment (ROS) morphogenesis (By similarity). May play a role with PRPH2 in the maintenance of the structure of ROS curved disks (PubMed:24196967). Plays a role in the organization of the ROS and maintenance of ROS disk diameter (By similarity). Involved in the maintenance of the retina outer nuclear layer (By similarity). Taurus_UMD|evm.model.AC_000186.1.340 Q9WU47 B3GA3_CRIGR 95.821 0.994048 1.00299 B3GAT3 - Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 - Cricetulus griseus (Chinese hamster) - B3GAT3 gene Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Highest activity seen with Gal-beta-1,3-Gal-beta-O-R (where R=naphthalenemethanol or benzyl alcohol). Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation. Taurus_UMD|evm.model.AC_000186.1.341 P79403 GANAB_PIG 91.396 0.984488 1.02436 GANAB - Neutral alpha-glucosidase AB precursor - Sus scrofa (Pig) - GANAB gene Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia. Taurus_UMD|evm.model.AC_000186.1.342 Q6P9B9 INT5_HUMAN 96.663 0.998037 1 INTS5 - Integrator complex subunit 5 - Homo sapiens (Human) - INTS5 gene Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). Taurus_UMD|evm.model.AC_000186.1.343 E9PRG8 CK098_HUMAN 88.618 0.983871 1.00813 C11orf98 - Uncharacterized protein C11orf98 - Homo sapiens (Human) - C11orf98 gene Taurus_UMD|evm.model.AC_000186.1.344 A8MUP2 CSKMT_HUMAN 84.519 0.987552 1.00417 CSKMT - Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial precursor - Homo sapiens (Human) - CSKMT gene Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria (PubMed:28391595, PubMed:28887308). Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methly group per binding event (PubMed:28887308). Taurus_UMD|evm.model.AC_000186.1.345 Q9BQE6 LBHD1_HUMAN 65.278 0.968326 0.764706 LBHD1 - LBH domain-containing protein 1 - Homo sapiens (Human) - LBHD1 gene nucleus, positive regulation of transcription, DNA-templated Taurus_UMD|evm.model.AC_000186.1.346 Q148G8 UQCC3_BOVIN 100.000 0.712121 1.38947 UQCC3 - Ubiquinol-cytochrome-c reductase complex assembly factor 3 - Bos taurus (Bovine) - UQCC3 gene Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. Taurus_UMD|evm.model.AC_000186.1.347 Q32KW2 UBXN1_BOVIN 100.000 0.993289 1.00337 UBXN1 - UBX domain-containing protein 1 - Bos taurus (Bovine) - UBXN1 gene Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (By similarity). Taurus_UMD|evm.model.AC_000186.1.348 Q3SWY4 LRN4L_BOVIN 100.000 0.991416 1.00431 LRRN4CL - LRRN4 C-terminal-like protein precursor - Bos taurus (Bovine) - LRRN4CL gene Taurus_UMD|evm.model.AC_000186.1.349 Q5E9P6 BSCL2_BOVIN 99.495 0.856833 1.17005 BSCL2 - Seipin - Bos taurus (Bovine) - BSCL2 gene Plays a crucial role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity). In association with TMEM159/LDAF1, defines the sites of LD formation in the ER (By similarity). Also required for growth and maturation of small nascent LDs into larger mature LDs (By similarity). Mediates the formation and/or stabilization of endoplasmic reticulum-lipid droplets (ER-LD) contacts, facilitating protein and lipid delivery from the ER into growing LDs (By similarity). Regulates the maturation of ZFYVE1-positive nascent LDs and the function of the RAB18-ZFYVE1 complex in mediating the formation of ER-LD contacts (By similarity). Binds anionic phospholipids including phosphatidic acid (By similarity). Plays an important role in the differentiation and development of adipocytes (By similarity). Taurus_UMD|evm.model.AC_000186.1.350 P63216 GBG3_MOUSE 100.000 0.973684 1.01333 Gng3 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 precursor - Mus musculus (Mouse) - Gng3 gene Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Taurus_UMD|evm.model.AC_000186.1.351 Q1KMD3 HNRL2_HUMAN 97.063 0.997333 1.00402 HNRNPUL2 - Heterogeneous nuclear ribonucleoprotein U-like protein 2 - Homo sapiens (Human) - HNRNPUL2 gene membrane, nucleoplasm, nucleus, RNA binding Taurus_UMD|evm.model.AC_000186.1.352 A4IFF3 TTC9C_BOVIN 100.000 0.988372 1.00585 TTC9C - Tetratricopeptide repeat protein 9C - Bos taurus (Bovine) - TTC9C gene Taurus_UMD|evm.model.AC_000186.1.353 Q9H5J0 ZBTB3_HUMAN 86.782 0.996109 0.89547 ZBTB3 - Zinc finger and BTB domain-containing protein 3 - Homo sapiens (Human) - ZBTB3 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000186.1.354 P62489 RPB7_RAT 100.000 0.988439 1.00581 Polr2g - DNA-directed RNA polymerase II subunit RPB7 - Rattus norvegicus (Rat) - Polr2g gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA (By similarity). Taurus_UMD|evm.model.AC_000186.1.355 Q9Y6J9 TAF6L_HUMAN 93.730 0.985646 1.00804 TAF6L - TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L - Homo sapiens (Human) - TAF6L gene Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity). Taurus_UMD|evm.model.AC_000186.1.356 Q7Z7N9 T179B_HUMAN 84.932 0.990868 1 TMEM179B - Transmembrane protein 179B - Homo sapiens (Human) - TMEM179B gene azurophil granule membrane, ficolin-1-rich granule membrane, nuclear speck, nucleolus, plasma membrane, secretory granule membrane, neutrophil degranulation Taurus_UMD|evm.model.AC_000186.1.357 A5PJW2 TM223_BOVIN 99.505 0.990148 1.00495 TMEM223 - Transmembrane protein 223 - Bos taurus (Bovine) - TMEM223 gene nervous system development Taurus_UMD|evm.model.AC_000186.1.358 Q1RMS5 NXF1_BOVIN 100.000 0.996779 1.00161 NXF1 - Nuclear RNA export factor 1 - Bos taurus (Bovine) - NXF1 gene Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. Taurus_UMD|evm.model.AC_000186.1.359 Q08DB5 STX5_BOVIN 100.000 0.705179 1.41408 STX5 - Syntaxin-5 - Bos taurus (Bovine) - STX5 gene Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Taurus_UMD|evm.model.AC_000186.1.360 Q58D06 WDR74_BOVIN 100.000 0.664835 1.41818 WDR74 - WD repeat-containing protein 74 - Bos taurus (Bovine) - WDR74 gene Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL. Taurus_UMD|evm.model.AC_000186.1.361 P08195 4F2_HUMAN 78.731 0.933682 0.909524 SLC3A2 - 4F2 cell-surface antigen heavy chain - Homo sapiens (Human) - SLC3A2 gene Component of several heterodimeric complexes involved in amino acid transport (PubMed:11557028, PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:30341327). The precise substrate specificity depends on the other subunit in the heterodimer (PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:30867591, PubMed:10903140). The complexes function as amino acid exchangers (PubMed:11557028, PubMed:10903140, PubMed:12117417, PubMed:12225859, PubMed:30867591). The homodimer functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:11557028, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591). The heterodimer formed by SLC3A2 and SLC7A6 or SLC3A2 and SLC7A7 mediates the uptake of dibasic amino acids (PubMed:9829974, PubMed:10903140). The heterodimer with SLC7A5/LAT1 mediates the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859). The heterodimer with SLC7A5/LAT1 is involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). The heterodimer with SLC7A5/LAT1 is involved in the uptake of leucine (PubMed:25998567, PubMed:30341327). When associated with LAPTM4B, the heterodimer with SLC7A5/LAT1 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). The heterodimer with SLC7A5/LAT1 may play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). The heterodimer formed by SLC3A2 and SLC7A5/LAT1 or SLC3A2 and SLC7A8/LAT2 is involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (PubMed:15769744). Together with ICAM1, regulates the transport activity of SLC7A8/LAT2 in polarized intestinal cells by generating and delivering intracellular signals (PubMed:12716892). Required for targeting of SLC7A5/LAT1 and SLC7A8/LAT2 to the plasma membrane and for channel activity (PubMed:9751058, PubMed:11311135, PubMed:30867591). Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine (PubMed:14603368). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Taurus_UMD|evm.model.AC_000186.1.362 P04761 ACM1_PIG 91.304 0.995633 0.995652 CHRM1 - Muscarinic acetylcholine receptor M1 - Sus scrofa (Pig) - CHRM1 gene The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Taurus_UMD|evm.model.AC_000186.1.363 Q864Z3 S22A6_BOVIN 77.619 0.384191 0.990893 SLC22A6 - Solute carrier family 22 member 6 - Bos taurus (Bovine) - SLC22A6 gene Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of p-aminohippurate (PAH), 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), indomethacin, sulindac, diclofenac, carprofen, okadaic acid, benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, bumetamide, losartan, probenecid, phenol red, urate, glutarate and alpha-ketoglutarate (By similarity). Taurus_UMD|evm.model.AC_000186.1.364 Q864Z3 S22A6_BOVIN 99.636 0.996364 1.00182 SLC22A6 - Solute carrier family 22 member 6 - Bos taurus (Bovine) - SLC22A6 gene Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of p-aminohippurate (PAH), 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), indomethacin, sulindac, diclofenac, carprofen, okadaic acid, benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, bumetamide, losartan, probenecid, phenol red, urate, glutarate and alpha-ketoglutarate (By similarity). Taurus_UMD|evm.model.AC_000186.1.365 Q70BM6 S22A8_PIG 85.267 0.996324 1.00184 SLC22A8 - Solute carrier family 22 member 8 - Sus scrofa (Pig) - SLC22A8 gene Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Taurus_UMD|evm.model.AC_000186.1.366 Q63ZE4 S22AA_HUMAN 63.360 0.972387 0.937153 SLC22A10 - Solute carrier family 22 member 10 - Homo sapiens (Human) - SLC22A10 gene organic anion transport Taurus_UMD|evm.model.AC_000186.1.367 Q63ZE4 S22AA_HUMAN 66.355 0.965642 1.02218 SLC22A10 - Solute carrier family 22 member 10 - Homo sapiens (Human) - SLC22A10 gene organic anion transport Taurus_UMD|evm.model.AC_000186.1.368 Q63ZE4 S22AA_HUMAN 68.105 0.996255 0.987061 SLC22A10 - Solute carrier family 22 member 10 - Homo sapiens (Human) - SLC22A10 gene organic anion transport Taurus_UMD|evm.model.AC_000186.1.369 Q63ZE4 S22AA_HUMAN 67.850 0.923875 1.06839 SLC22A10 - Solute carrier family 22 member 10 - Homo sapiens (Human) - SLC22A10 gene organic anion transport Taurus_UMD|evm.model.AC_000186.1.370 Q63ZE4 S22AA_HUMAN 65.121 0.972578 1.01109 SLC22A10 - Solute carrier family 22 member 10 - Homo sapiens (Human) - SLC22A10 gene organic anion transport Taurus_UMD|evm.model.AC_000186.1.371 Q2KIV1 S22A9_BOVIN 97.561 0.47807 1.23913 SLC22A9 - Solute carrier family 22 member 9 - Bos taurus (Bovine) - SLC22A9 gene Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes (By similarity). Taurus_UMD|evm.model.AC_000186.1.372 Q96DT0 LEG12_HUMAN 85.942 0.990476 0.9375 LGALS12 - Galectin-12 - Homo sapiens (Human) - LGALS12 gene Binds lactose. May participate in the apoptosis of adipocytes. Taurus_UMD|evm.model.AC_000186.1.373 Q9NWW9 PLAT2_HUMAN 64.706 0.84 0.617284 PLAAT2 - Phospholipase A and acyltransferase 2 - Homo sapiens (Human) - PLAAT2 gene Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22825852, PubMed:22605381). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22825852, PubMed:22605381). Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor (PubMed:22605381). Exhibits high phospholipase A1/2 activity and low N-acyltransferase activity (PubMed:22825852). Taurus_UMD|evm.model.AC_000186.1.374 P53816 PLAT3_HUMAN 74.522 0.96875 0.987654 PLAAT3 - Phospholipase A and acyltransferase 3 - Homo sapiens (Human) - PLAAT3 gene Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:22923616). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PubMed:22825852). Taurus_UMD|evm.model.AC_000186.1.375 Q8R3U1 PLAT3_MOUSE 66.071 0.982143 0.691358 Plaat3 - Phospholipase A and acyltransferase 3 - Mus musculus (Mouse) - Plaat3 gene Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19047760). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:18614531, PubMed:19047760, PubMed:19136964, PubMed:22134920). For most substrates, PLA1 activity is much higher than PLA2 activity (By similarity). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (By similarity). Shows N-acyltransferase activity,catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19047760). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (By similarity). Taurus_UMD|evm.model.AC_000186.1.376 Q8R3U1 PLAT3_MOUSE 57.447 0.915033 0.944444 Plaat3 - Phospholipase A and acyltransferase 3 - Mus musculus (Mouse) - Plaat3 gene Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19047760). Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:18614531, PubMed:19047760, PubMed:19136964, PubMed:22134920). For most substrates, PLA1 activity is much higher than PLA2 activity (By similarity). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (By similarity). Shows N-acyltransferase activity,catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19047760). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (By similarity). Taurus_UMD|evm.model.AC_000186.1.377 P53816 PLAT3_HUMAN 83.333 0.98773 1.00617 PLAAT3 - Phospholipase A and acyltransferase 3 - Homo sapiens (Human) - PLAAT3 gene Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:22923616). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PubMed:22825852). Taurus_UMD|evm.model.AC_000186.1.378 Q6DD88 ATLA3_HUMAN 94.270 0.99631 1.00185 ATL3 - Atlastin-3 - Homo sapiens (Human) - ATL3 gene GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977). Taurus_UMD|evm.model.AC_000186.1.379 O95197 RTN3_HUMAN 68.428 0.996068 0.739341 RTN3 - Reticulon-3 - Homo sapiens (Human) - RTN3 gene May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Taurus_UMD|evm.model.AC_000186.1.380 Q08D83 RTN3_BOVIN 97.479 0.369906 1.24609 RTN3 - Reticulon-3 - Bos taurus (Bovine) - RTN3 gene May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (By similarity). Taurus_UMD|evm.model.AC_000186.1.381 C9JLR9 CK095_HUMAN 85.202 0.853565 0.765487 ZFTA - Zinc finger translocation-associated protein - Homo sapiens (Human) - ZFTA gene negative regulation of transcription, DNA-templated Taurus_UMD|evm.model.AC_000186.1.382 Q9BUA3 SPNDC_HUMAN 80.779 0.994737 0.997375 SPINDOC - Spindlin interactor and repressor of chromatin-binding protein - Homo sapiens (Human) - SPINDOC gene Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway. Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846). Taurus_UMD|evm.model.AC_000186.1.384 Q7KZI7 MARK2_HUMAN 98.223 0.997459 0.998731 MARK2 - Serine/threonine-protein kinase MARK2 - Homo sapiens (Human) - MARK2 gene Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. Taurus_UMD|evm.model.AC_000186.1.385 Q8IZ40 RCOR2_HUMAN 97.706 0.996183 1.00191 RCOR2 - REST corepressor 2 - Homo sapiens (Human) - RCOR2 gene May act as a component of a corepressor complex that represses transcription. Taurus_UMD|evm.model.AC_000186.1.386 B2RYG6 OTUB1_RAT 99.262 0.992647 1.00369 Otub1 - Ubiquitin thioesterase OTUB1 - Rattus norvegicus (Rat) - Otub1 gene Hydrolase that can specifically remove compared to 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin (By similarity). Taurus_UMD|evm.model.AC_000186.1.387 Q2KHU5 MACD1_BOVIN 100.000 0.958457 1.03692 MACROD1 - ADP-ribose glycohydrolase MACROD1 - Bos taurus (Bovine) - MACROD1 gene Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. Taurus_UMD|evm.model.AC_000186.1.389 Q3ZBZ8 STIP1_BOVIN 100.000 0.903333 1.10497 STIP1 - Stress-induced-phosphoprotein 1 - Bos taurus (Bovine) - STIP1 gene Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. Taurus_UMD|evm.model.AC_000186.1.390 Q32LP0 URP2_BOVIN 100.000 0.913486 0.590977 FERMT3 - Fermitin family homolog 3 - Bos taurus (Bovine) - FERMT3 gene Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Taurus_UMD|evm.model.AC_000186.1.391 Q9D844 DNJC4_MOUSE 77.128 0.792373 0.967213 Dnajc4 - DnaJ homolog subfamily C member 4 - Mus musculus (Mouse) - Dnajc4 gene mitochondrion Taurus_UMD|evm.model.AC_000186.1.392 Q2TBI8 NUD22_BOVIN 100.000 0.969799 1.02759 NUDT22 - Uridine diphosphate glucose pyrophosphatase NUDT22 - Bos taurus (Bovine) - NUDT22 gene Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose. Taurus_UMD|evm.model.AC_000186.1.393 Q3ZBM7 TRPT1_BOVIN 99.606 0.881533 1.12992 TRPT1 - tRNA 2'-phosphotransferase 1 - Bos taurus (Bovine) - TRPT1 gene Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. Taurus_UMD|evm.model.AC_000186.1.394 Q32LP0 URP2_BOVIN 96.057 0.929766 0.449624 FERMT3 - Fermitin family homolog 3 - Bos taurus (Bovine) - FERMT3 gene Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Taurus_UMD|evm.model.AC_000186.1.395 Q9XS49 VEGFB_BOVIN 85.714 0.664894 0.908213 VEGFB - Vascular endothelial growth factor B precursor - Bos taurus (Bovine) - VEGFB gene Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis (By similarity). Taurus_UMD|evm.model.AC_000186.1.396 Q32PA9 FKBP2_BOVIN 100.000 0.852761 1.16429 FKBP2 - Peptidyl-prolyl cis-trans isomerase FKBP2 precursor - Bos taurus (Bovine) - FKBP2 gene PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Taurus_UMD|evm.model.AC_000186.1.397 Q8MIK9 PP14B_PIG 100.000 0.7625 0.544218 PPP1R14B - Protein phosphatase 1 regulatory subunit 14B - Sus scrofa (Pig) - PPP1R14B gene Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity). Taurus_UMD|evm.model.AC_000186.1.398 Q01970 PLCB3_HUMAN 92.488 0.998381 1.00081 PLCB3 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 - Homo sapiens (Human) - PLCB3 gene The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Taurus_UMD|evm.model.AC_000186.1.399 Q92934 BAD_HUMAN 78.107 0.988166 1.00595 BAD - Bcl2-associated agonist of cell death - Homo sapiens (Human) - BAD gene Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. Taurus_UMD|evm.model.AC_000186.1.400 Q17QQ5 G137A_BOVIN 100.000 0.994949 1.00253 GPR137 - Integral membrane protein GPR137 - Bos taurus (Bovine) - GPR137 gene Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. Taurus_UMD|evm.model.AC_000186.1.401 Q9NYG8 KCNK4_HUMAN 88.750 0.992537 1.0229 KCNK4 - Potassium channel subfamily K member 4 - Homo sapiens (Human) - KCNK4 gene Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157, PubMed:30290154). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity). Taurus_UMD|evm.model.AC_000186.1.402 Q9NTU4 CTSRZ_HUMAN 54.067 0.97561 1.025 CATSPERZ - Cation channel sperm-associated protein subunit zeta - Homo sapiens (Human) - CATSPERZ gene Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract. Together with EFCAB9, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel. Taurus_UMD|evm.model.AC_000186.1.403 P11474 ERR1_HUMAN 99.527 0.995272 1 ESRRA - Steroid hormone receptor ERR1 - Homo sapiens (Human) - ESRRA gene Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. Taurus_UMD|evm.model.AC_000186.1.404 Q2KIA2 TR112_BOVIN 100.000 0.659574 1.504 TRMT112 - Multifunctional methyltransferase subunit TRM112-like protein - Bos taurus (Bovine) - TRMT112 gene Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production. Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA. Taurus_UMD|evm.model.AC_000186.1.405 Q9BGI1 PRDX5_BOVIN 100.000 0.990909 1.00457 PRDX5 - Peroxiredoxin-5, mitochondrial precursor - Bos taurus (Bovine) - PRDX5 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Taurus_UMD|evm.model.AC_000186.1.406 A6NC98 CC88B_HUMAN 82.329 0.998634 0.99187 CCDC88B - Coiled-coil domain-containing protein 88B - Homo sapiens (Human) - CCDC88B gene Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). Taurus_UMD|evm.model.AC_000186.1.407 O75676 KS6A4_HUMAN 95.725 0.997409 1 RPS6KA4 - Ribosomal protein S6 kinase alpha-4 - Homo sapiens (Human) - RPS6KA4 gene Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Taurus_UMD|evm.model.AC_000186.1.409 Q9NSA0 S22AB_HUMAN 67.167 0.593468 1.61455 SLC22A11 - Solute carrier family 22 member 11 - Homo sapiens (Human) - SLC22A11 gene Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds. Taurus_UMD|evm.model.AC_000186.1.410 Q96S37 S22AC_HUMAN 59.735 0.995381 0.783002 SLC22A12 - Solute carrier family 22 member 12 - Homo sapiens (Human) - SLC22A12 gene Major urate transporter involved in renal reabsorption of urate and helps to maintain blood levels of uric acid (PubMed:12024214, PubMed:22194875). Translocates urate over the apical membrane of proximal tubular cells in exchange for organic anions or chloride ions (PubMed:12024214, PubMed:22194875). Taurus_UMD|evm.model.AC_000186.1.411 Q9P2S2 NRX2A_HUMAN 97.488 0.998821 0.990654 NRXN2 - Neurexin-2 precursor - Homo sapiens (Human) - NRXN2 gene Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Taurus_UMD|evm.model.AC_000186.1.412 A6N9I4 GRP2_BOVIN 98.052 0.996759 1.0148 RASGRP2 - RAS guanyl-releasing protein 2 - Bos taurus (Bovine) - RASGRP2 gene Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. Taurus_UMD|evm.model.AC_000186.1.413 P79334 PYGM_BOVIN 99.881 0.997628 1.00119 PYGM - Glycogen phosphorylase, muscle form - Bos taurus (Bovine) - PYGM gene Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Taurus_UMD|evm.model.AC_000186.1.414 Q15637 SF01_HUMAN 99.622 0.839428 0.984351 SF1 - Splicing factor 1 - Homo sapiens (Human) - SF1 gene Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. Taurus_UMD|evm.model.AC_000186.1.416 Q12851 M4K2_HUMAN 95.202 0.98875 0.97561 MAP4K2 - Mitogen-activated protein kinase kinase kinase kinase 2 - Homo sapiens (Human) - MAP4K2 gene Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Taurus_UMD|evm.model.AC_000186.1.417 Q0P5I0 MEN1_BOVIN 100.000 0.996727 1.00164 MEN1 - Menin - Bos taurus (Bovine) - MEN1 gene Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair (By similarity). Taurus_UMD|evm.model.AC_000186.1.418 Q6DT37 MRCKG_HUMAN 87.387 0.998705 0.995487 CDC42BPG - Serine/threonine-protein kinase MRCK gamma - Homo sapiens (Human) - CDC42BPG gene May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). Taurus_UMD|evm.model.AC_000186.1.419 Q5E9R3 EHD1_BOVIN 100.000 0.989189 0.692884 EHD1 - EH domain-containing protein 1 - Bos taurus (Bovine) - EHD1 gene ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Plays a role in myoblast fusion. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis. Taurus_UMD|evm.model.AC_000186.1.420 Q2TAZ0 ATG2A_HUMAN 88.171 0.984298 0.5258 ATG2A - Autophagy-related protein 2 homolog A - Homo sapiens (Human) - ATG2A gene Involved in autophagosome assembly, regulating the size of nascent autophagosomes (PubMed:28561066). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (By similarity). Taurus_UMD|evm.model.AC_000186.1.421 Q5E9R3 EHD1_BOVIN 100.000 0.762557 0.410112 EHD1 - EH domain-containing protein 1 - Bos taurus (Bovine) - EHD1 gene ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Plays a role in myoblast fusion. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis. Taurus_UMD|evm.model.AC_000186.1.422 Q2TAZ0 ATG2A_HUMAN 85.397 0.987302 0.487616 ATG2A - Autophagy-related protein 2 homolog A - Homo sapiens (Human) - ATG2A gene Involved in autophagosome assembly, regulating the size of nascent autophagosomes (PubMed:28561066). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (By similarity). Taurus_UMD|evm.model.AC_000186.1.423 Q15173 2A5B_HUMAN 98.994 0.995976 1 PPP2R5B - Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform - Homo sapiens (Human) - PPP2R5B gene As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. Taurus_UMD|evm.model.AC_000186.1.424 Q96T91 GPHA2_HUMAN 88.189 0.984375 0.992248 GPHA2 - Glycoprotein hormone alpha-2 precursor - Homo sapiens (Human) - GPHA2 gene Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production (PubMed:12045258). Plays a central role in controlling thyroid cell metabolism (PubMed:12045258). Taurus_UMD|evm.model.AC_000186.1.425 Q3KP22 MAJIN_HUMAN 93.878 0.186047 1.46591 MAJIN - Membrane-anchored junction protein - Homo sapiens (Human) - MAJIN gene Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. Taurus_UMD|evm.model.AC_000186.1.426 Q8N1L9 BATF2_HUMAN 70.182 0.992754 1.0073 BATF2 - Basic leucine zipper transcriptional factor ATF-like 2 - Homo sapiens (Human) - BATF2 gene AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter. Taurus_UMD|evm.model.AC_000186.1.427 Q2TA37 ARL2_BOVIN 100.000 0.989189 1.00543 ARL2 - ADP-ribosylation factor-like protein 2 - Bos taurus (Bovine) - ARL2 gene Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Taurus_UMD|evm.model.AC_000186.1.428 Q148E7 SNX15_BOVIN 100.000 0.99422 1.0029 SNX15 - Sorting nexin-15 - Bos taurus (Bovine) - SNX15 gene May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity). Taurus_UMD|evm.model.AC_000186.1.429 A6NKF1 SAC31_HUMAN 82.865 0.988858 0.888614 SAC3D1 - SAC3 domain-containing protein 1 - Homo sapiens (Human) - SAC3D1 gene Involved in centrosome duplication and mitotic progression. Taurus_UMD|evm.model.AC_000186.1.430 Q9UQQ1 NALDL_HUMAN 82.550 0.997315 1.00676 NAALADL1 - Aminopeptidase NAALADL1 - Homo sapiens (Human) - NAALADL1 gene Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position (PubMed:25752612). Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity (PubMed:25752612). Taurus_UMD|evm.model.AC_000186.1.431 Q96FF9 CDCA5_HUMAN 68.085 0.446565 2.07937 CDCA5 - Sororin - Homo sapiens (Human) - CDCA5 gene Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. Taurus_UMD|evm.model.AC_000186.1.432 Q2YDD3 ZFPL1_BOVIN 92.857 0.993808 1.03526 ZFPL1 - Zinc finger protein-like 1 - Bos taurus (Bovine) - ZFPL1 gene Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130 (By similarity). Taurus_UMD|evm.model.AC_000186.1.433 E9PQX1 TM262_HUMAN 78.070 0.949153 1.01724 TMEM262 - Transmembrane protein 262 - Homo sapiens (Human) - TMEM262 gene Taurus_UMD|evm.model.AC_000186.1.434 A6QQ47 VPS51_BOVIN 100.000 0.552518 0.889885 VPS51 - Vacuolar protein sorting-associated protein 51 homolog - Bos taurus (Bovine) - VPS51 gene Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Taurus_UMD|evm.model.AC_000186.1.435 Q8WMV1 ERG24_BOVIN 99.282 0.995227 1.00239 TM7SF2 - Delta(14)-sterol reductase TM7SF2 - Bos taurus (Bovine) - TM7SF2 gene Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Taurus_UMD|evm.model.AC_000186.1.436 Q2TBW5 ZNHI2_BOVIN 100.000 0.995 1.00251 ZNHIT2 - Zinc finger HIT domain-containing protein 2 - Bos taurus (Bovine) - ZNHIT2 gene May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP) (By similarity). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (By similarity). May play a role in regulating the composition of the U5 snRNP complex (By similarity). Taurus_UMD|evm.model.AC_000186.1.437 P62864 RS30_RAT 100.000 0.574257 1.71186 Fau - 40S ribosomal protein S30 - Rattus norvegicus (Rat) - Fau gene antimicrobial humoral immune response mediated by antimicrobial peptide, defense response to Gram-positive bacterium Taurus_UMD|evm.model.AC_000186.1.438 Q5EA71 RM49_BOVIN 97.590 0.987879 0.993976 MRPL49 - 39S ribosomal protein L49, mitochondrial - Bos taurus (Bovine) - MRPL49 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, structural constituent of ribosome Taurus_UMD|evm.model.AC_000186.1.439 Q86TM6 SYVN1_HUMAN 94.165 0.996732 0.991896 SYVN1 - E3 ubiquitin-protein ligase synoviolin - Homo sapiens (Human) - SYVN1 gene E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28827405). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28842558). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity). During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells (By similarity). Taurus_UMD|evm.model.AC_000186.1.440 Q5MJ68 SPDYC_HUMAN 65.672 0.858553 1.03754 SPDYC - Speedy protein C - Homo sapiens (Human) - SPDYC gene Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase. Taurus_UMD|evm.model.AC_000186.1.441 Q27970 CAN1_BOVIN 100.000 0.547771 1.75419 CAPN1 - Calpain-1 catalytic subunit - Bos taurus (Bovine) - CAPN1 gene Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1. Taurus_UMD|evm.model.AC_000186.1.442 Q58D13 DPOA2_BOVIN 99.819 0.915141 0.995033 POLA2 - DNA polymerase alpha subunit B - Bos taurus (Bovine) - POLA2 gene Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). Taurus_UMD|evm.model.AC_000186.1.443 Q08DN6 BORG1_BOVIN 100.000 0.990521 1.00476 CDC42EP2 - Cdc42 effector protein 2 - Bos taurus (Bovine) - CDC42EP2 gene Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000186.1.444 Q92785 REQU_HUMAN 99.744 0.994898 1.00256 DPF2 - Zinc finger protein ubi-d4 - Homo sapiens (Human) - DPF2 gene Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:28533407, PubMed:27775714). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). Taurus_UMD|evm.model.AC_000186.1.445 Q6B0B8 TIGD3_HUMAN 84.501 0.995763 1.00212 TIGD3 - Tigger transposable element-derived protein 3 - Homo sapiens (Human) - TIGD3 gene nucleus, DNA binding Taurus_UMD|evm.model.AC_000186.1.446 Q8N413 S2545_HUMAN 89.236 0.99308 1.00347 SLC25A45 - Solute carrier family 25 member 45 - Homo sapiens (Human) - SLC25A45 gene acyl carnitine transmembrane transporter activity, acyl carnitine transport, amino acid transport Taurus_UMD|evm.model.AC_000186.1.447 Q9BZ67 FRMD8_HUMAN 87.742 0.99569 1 FRMD8 - FERM domain-containing protein 8 - Homo sapiens (Human) - FRMD8 gene Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). Taurus_UMD|evm.model.AC_000186.1.448 A6QLH6 SCYL1_BOVIN 99.752 0.997525 1.00124 SCYL1 - N-terminal kinase-like protein - Bos taurus (Bovine) - SCYL1 gene Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro. Taurus_UMD|evm.model.AC_000186.1.449 Q9NS15 LTBP3_HUMAN 94.781 0.998459 0.996163 LTBP3 - Latent-transforming growth factor beta-binding protein 3 precursor - Homo sapiens (Human) - LTBP3 gene Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Taurus_UMD|evm.model.AC_000186.1.450 O60232 ZNRD2_HUMAN 95.477 0.99 1.00503 ZNRD2 - Protein ZNRD2 - Homo sapiens (Human) - ZNRD2 gene Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies. Taurus_UMD|evm.model.AC_000186.1.451 Q8N5H3 LRA25_HUMAN 94.271 0.989637 1.02116 FAM89B - Leucine repeat adapter protein 25 - Homo sapiens (Human) - FAM89B gene Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. Taurus_UMD|evm.model.AC_000186.1.452 Q8N3D4 EH1L1_HUMAN 70.871 0.998622 0.952725 EHBP1L1 - EH domain-binding protein 1-like protein 1 - Homo sapiens (Human) - EHBP1L1 gene May act as Rab effector protein and play a role in vesicle trafficking. Taurus_UMD|evm.model.AC_000186.1.453 Q9Y2U2 KCNK7_HUMAN 81.107 0.993506 1.00326 KCNK7 - Potassium channel subfamily K member 7 - Homo sapiens (Human) - KCNK7 gene Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane. Taurus_UMD|evm.model.AC_000186.1.454 Q16584 M3K11_HUMAN 92.477 0.997688 1.02125 MAP3K11 - Mitogen-activated protein kinase kinase kinase 11 - Homo sapiens (Human) - MAP3K11 gene Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. Taurus_UMD|evm.model.AC_000186.1.455 Q9H6A9 PCX3_HUMAN 93.765 0.645788 1.56981 PCNX3 - Pecanex-like protein 3 - Homo sapiens (Human) - PCNX3 gene Taurus_UMD|evm.model.AC_000186.1.456 Q04206 TF65_HUMAN 88.592 0.996377 1.00181 RELA - Transcription factor p65 - Homo sapiens (Human) - RELA gene NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). Taurus_UMD|evm.model.AC_000186.1.457 Q99MK2 KAT5_RAT 99.804 0.928702 1.06628 Kat5 - Histone acetyltransferase KAT5 - Rattus norvegicus (Rat) - Kat5 gene Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Also acetylates non-histone proteins, such as ATM, NR1D2, RAN, FOXP3, ULK1 and RUBCNL/Pacer. Directly acetylates and activates ATM. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity. Acetylates RAN at 'Lys-134'. Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer. Taurus_UMD|evm.model.AC_000186.1.458 Q2M2U4 RNH2C_BOVIN 100.000 0.987952 1.00606 RNASEH2C - Ribonuclease H2 subunit C - Bos taurus (Bovine) - RNASEH2C gene Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity). Taurus_UMD|evm.model.AC_000186.1.459 G3MZC5 AP5B1_BOVIN 100.000 0.997722 1.00114 AP5B1 - AP-5 complex subunit beta-1 - Bos taurus (Bovine) - AP5B1 gene As part of AP-5, a probable fifth adaptor protein complex, it may be involved in endosomal transport. Taurus_UMD|evm.model.AC_000186.1.460 A2VDT4 OVOL1_BOVIN 100.000 0.992537 1.00375 OVOL1 - Putative transcription factor Ovo-like 1 - Bos taurus (Bovine) - OVOL1 gene Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity). Taurus_UMD|evm.model.AC_000186.1.461 E9Q6E9 SIMC1_MOUSE 31.618 0.278008 0.355982 Simc1 - SUMO-interacting motif-containing protein 1 - Mus musculus (Mouse) - Simc1 gene Inhibits the protease activity of CAPN3. Taurus_UMD|evm.model.AC_000186.1.462 Q86XE0 SNX32_HUMAN 65.789 0.240385 0.774194 SNX32 - Sorting nexin-32 - Homo sapiens (Human) - SNX32 gene May be involved in several stages of intracellular trafficking. Taurus_UMD|evm.model.AC_000186.1.463 Q6B7M7 COF1_SHEEP 100.000 0.988024 1.00602 CFL1 - Cofilin-1 - Ovis aries (Sheep) - CFL1 gene Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (By similarity). Important for normal progress through mitosis and normal cytokinesis (By similarity). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (By similarity). Taurus_UMD|evm.model.AC_000186.1.464 Q96NY9 MUS81_HUMAN 86.594 0.996383 1.00363 MUS81 - Crossover junction endonuclease MUS81 - Homo sapiens (Human) - MUS81 gene Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. Taurus_UMD|evm.model.AC_000186.1.465 O55058 FBLN4_CRIGR 97.065 0.793537 1.25734 EFEMP2 - EGF-containing fibulin-like extracellular matrix protein 2 precursor - Cricetulus griseus (Chinese hamster) - EFEMP2 gene Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta. In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin. Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction. Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling. Taurus_UMD|evm.model.AC_000186.1.466 Q9TST1 CATW_FELCA 72.606 0.994667 1.00267 CTSW - Cathepsin W precursor - Felis catus (Cat) - CTSW gene May have a specific function in the mechanism or regulation of T-cell cytolytic activity. Taurus_UMD|evm.model.AC_000186.1.467 O46431 FIBP_CHLAE 98.880 0.994413 1.0028 FIBP - Acidic fibroblast growth factor intracellular-binding protein - Chlorocebus aethiops (Green monkey) - FIBP gene May be involved in mitogenic function of FGF1 (By similarity). May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity). Taurus_UMD|evm.model.AC_000186.1.468 Q6PDY0 CC85B_MOUSE 98.020 0.990148 1.00495 Ccdc85b - Coiled-coil domain-containing protein 85B - Mus musculus (Mouse) - Ccdc85b gene Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (PubMed:15644333, PubMed:22666460). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). Taurus_UMD|evm.model.AC_000186.1.469 P15407 FOSL1_HUMAN 91.241 0.992647 1.00369 FOSL1 - Fos-related antigen 1 - Homo sapiens (Human) - FOSL1 gene chromatin, nucleoplasm, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, cellular defense response, chemotaxis, positive regulation of cell population proliferation Taurus_UMD|evm.model.AC_000186.1.470 A4IFA8 CK068_BOVIN 100.000 0.993174 1.00342 UPF0696 protein C11orf68 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.471 Q2YDP3 NC2A_BOVIN 100.000 0.990291 1.00488 DRAP1 - Dr1-associated corepressor - Bos taurus (Bovine) - DRAP1 gene The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity). Taurus_UMD|evm.model.AC_000186.1.472 A5D7I0 T10IP_BOVIN 100.000 0.996409 1.0018 TSGA10IP - Testis-specific protein 10-interacting protein - Bos taurus (Bovine) - TSGA10IP gene photoreceptor connecting cilium, cilium organization Taurus_UMD|evm.model.AC_000186.1.473 Q9Z315 SNUT1_MOUSE 93.921 0.997509 0.996278 Sart1 - U4/U6.U5 tri-snRNP-associated protein 1 - Mus musculus (Mouse) - Sart1 gene Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. Appears to play a role in hypoxia-induced regulation of EPO gene expression. Taurus_UMD|evm.model.AC_000186.1.474 Q58CY2 EIF1A_BOVIN 100.000 0.988024 1.00602 EIF1AD - Probable RNA-binding protein EIF1AD - Bos taurus (Bovine) - EIF1AD gene Plays a role into cellular response to oxidative stress. Decreases cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000186.1.475 Q5RBU9 BAF_PONAB 100.000 0.606897 1.62921 BANF1 - Barrier-to-autointegration factor - Pongo abelii (Sumatran orangutan) - BANF1 gene Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. Taurus_UMD|evm.model.AC_000186.1.476 Q8NEC5 CTSR1_HUMAN 73.810 0.282759 0.185897 CATSPER1 - Cation channel sperm-associated protein 1 - Homo sapiens (Human) - CATSPER1 gene Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Taurus_UMD|evm.model.AC_000186.1.477 Q15828 CYTM_HUMAN 81.429 0.676471 0.684564 CST6 - Cystatin-M precursor - Homo sapiens (Human) - CST6 gene High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain (PubMed:30425301). Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance (PubMed:30425301). Taurus_UMD|evm.model.AC_000186.1.478 Q8NEC5 CTSR1_HUMAN 52.497 0.992436 0.847436 CATSPER1 - Cation channel sperm-associated protein 1 - Homo sapiens (Human) - CATSPER1 gene Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Taurus_UMD|evm.model.AC_000186.1.479 Q0VCH4 G3ST3_BOVIN 100.000 0.812379 1.21077 GAL3ST3 - Galactose-3-O-sulfotransferase 3 - Bos taurus (Bovine) - GAL3ST3 gene Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc (By similarity). Taurus_UMD|evm.model.AC_000186.1.480 Q13435 SF3B2_HUMAN 97.216 0.997768 1.00112 SF3B2 - Splicing factor 3B subunit 2 - Homo sapiens (Human) - SF3B2 gene Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). Taurus_UMD|evm.model.AC_000186.1.481 P62752 RL23A_RAT 95.745 0.596154 1 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000186.1.482 Q6VY07 PACS1_HUMAN 97.423 0.993895 0.850467 PACS1 - Phosphofurin acidic cluster sorting protein 1 - Homo sapiens (Human) - PACS1 gene Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Taurus_UMD|evm.model.AC_000186.1.483 O88448 KLC2_MOUSE 93.950 0.642162 1.54424 Klc2 - Kinesin light chain 2 - Mus musculus (Mouse) - Klc2 gene Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends. Taurus_UMD|evm.model.AC_000186.1.484 Q3T196 YIF1A_BOVIN 100.000 0.993197 1.00341 YIF1A - Protein YIF1A - Bos taurus (Bovine) - YIF1A gene Possible role in transport between endoplasmic reticulum and Golgi. Taurus_UMD|evm.model.AC_000186.1.485 A4IFG4 T151B_BOVIN 99.775 0.958874 0.987179 TMEM151B - Transmembrane protein 151B - Bos taurus (Bovine) - TMEM151B gene Taurus_UMD|evm.model.AC_000186.1.486 Q9HCU0 CD248_HUMAN 77.851 0.980695 1.02642 CD248 - Endosialin precursor - Homo sapiens (Human) - CD248 gene May play a role in tumor angiogenesis. Taurus_UMD|evm.model.AC_000186.1.487 Q13671 RIN1_HUMAN 83.418 0.997472 1.01022 RIN1 - Ras and Rab interactor 1 - Homo sapiens (Human) - RIN1 gene Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. Taurus_UMD|evm.model.AC_000186.1.488 Q1LZE0 BRMS1_BOVIN 100.000 0.822148 1.21138 BRMS1 - Breast cancer metastasis-suppressor 1 homolog - Bos taurus (Bovine) - BRMS1 gene Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis (By similarity). Taurus_UMD|evm.model.AC_000186.1.489 Q5EA01 B4GA1_BOVIN 100.000 0.995192 1.00241 B4GAT1 - Beta-1,4-glucuronyltransferase 1 - Bos taurus (Bovine) - B4GAT1 gene Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan. Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1). Taurus_UMD|evm.model.AC_000186.1.490 Q14542 S29A2_HUMAN 82.646 0.98081 1.02851 SLC29A2 - Equilibrative nucleoside transporter 2 - Homo sapiens (Human) - SLC29A2 gene Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine. Taurus_UMD|evm.model.AC_000186.1.491 Q8IUM7 NPAS4_HUMAN 92.683 0.920814 0.551122 NPAS4 - Neuronal PAS domain-containing protein 4 - Homo sapiens (Human) - NPAS4 gene Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (By similarity). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734). Can activate the CME (CNS midline enhancer) element (PubMed:14701734). Taurus_UMD|evm.model.AC_000186.1.492 Q8IUM7 NPAS4_HUMAN 90.704 0.994318 0.438903 NPAS4 - Neuronal PAS domain-containing protein 4 - Homo sapiens (Human) - NPAS4 gene Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (By similarity). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734). Can activate the CME (CNS midline enhancer) element (PubMed:14701734). Taurus_UMD|evm.model.AC_000186.1.493 Q2YDI0 RM11_BOVIN 100.000 0.989637 1.00521 MRPL11 - 39S ribosomal protein L11, mitochondrial precursor - Bos taurus (Bovine) - MRPL11 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit Taurus_UMD|evm.model.AC_000186.1.494 Q8BXR6 PELI3_MOUSE 96.854 0.995516 1.00225 Peli3 - E3 ubiquitin-protein ligase pellino homolog 3 - Mus musculus (Mouse) - Peli3 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. Taurus_UMD|evm.model.AC_000186.1.495 Q9NY33 DPP3_HUMAN 94.513 0.969374 1.019 DPP3 - Dipeptidyl peptidase 3 - Homo sapiens (Human) - DPP3 gene Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758). Taurus_UMD|evm.model.AC_000186.1.496 Q8NFJ9 BBS1_HUMAN 87.565 0.973064 1.00169 BBS1 - Bardet-Biedl syndrome 1 protein - Homo sapiens (Human) - BBS1 gene The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (PubMed:17574030, PubMed:22072986). Plays a role in olfactory cilium biogenesis/maintenance and trafficking (By similarity). Taurus_UMD|evm.model.AC_000186.1.497 Q6UX98 ZDH24_HUMAN 93.310 0.992982 1.00352 ZDHHC24 - Probable palmitoyltransferase ZDHHC24 - Homo sapiens (Human) - ZDHHC24 gene Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Taurus_UMD|evm.model.AC_000186.1.498 Q0III9 ACTN3_BOVIN 98.002 0.997738 0.981132 ACTN3 - Alpha-actinin-3 - Bos taurus (Bovine) - ACTN3 gene F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). Taurus_UMD|evm.model.AC_000186.1.499 Q9R013 CATF_MOUSE 78.652 0.963124 0.997835 Ctsf - Cathepsin F precursor - Mus musculus (Mouse) - Ctsf gene Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Taurus_UMD|evm.model.AC_000186.1.500 Q9NVE4 CCD87_HUMAN 65.562 0.977855 1.0106 CCDC87 - Coiled-coil domain-containing protein 87 - Homo sapiens (Human) - CCDC87 gene Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility. Taurus_UMD|evm.model.AC_000186.1.501 Q6PWT7 CCS_PIG 92.336 0.992727 1.00365 CCS - Copper chaperone for superoxide dismutase - Sus scrofa (Pig) - CCS gene Delivers copper to copper zinc superoxide dismutase (SOD1). Taurus_UMD|evm.model.AC_000186.1.502 Q5EA36 RBM14_BOVIN 100.000 0.940678 0.176383 RBM14 - RNA-binding protein 14 - Bos taurus (Bovine) - RBM14 gene May function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Taurus_UMD|evm.model.AC_000186.1.503 Q3MHX3 RBM4_BOVIN 100.000 0.99449 1.00276 RBM4 - RNA-binding protein 4 - Bos taurus (Bovine) - RBM4 gene RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro (By similarity). Taurus_UMD|evm.model.AC_000186.1.504 Q06AT9 RBM4B_PIG 98.607 0.994444 1.00279 RBM4B - RNA-binding protein 4B - Sus scrofa (Pig) - RBM4B gene Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity). Taurus_UMD|evm.model.AC_000186.1.505 O15020 SPTN2_HUMAN 93.399 0.990253 0.643933 SPTBN2 - Spectrin beta chain, non-erythrocytic 2 - Homo sapiens (Human) - SPTBN2 gene Probably plays an important role in neuronal membrane skeleton. Taurus_UMD|evm.model.AC_000186.1.506 Q8N6T0 TO6BL_HUMAN 70.495 0.995943 0.854419 TOP6BL - Type 2 DNA topoisomerase 6 subunit B-like - Homo sapiens (Human) - TOP6BL gene Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Taurus_UMD|evm.model.AC_000186.1.507 Q9Y256 FACE2_HUMAN 98.176 0.993939 1.00304 RCE1 - CAAX prenyl protease 2 - Homo sapiens (Human) - RCE1 gene Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068). Taurus_UMD|evm.model.AC_000186.1.508 Q29RK2 PYC_BOVIN 100.000 0.998304 1.00085 PC - Pyruvate carboxylase, mitochondrial precursor - Bos taurus (Bovine) - PC gene Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (By similarity). Taurus_UMD|evm.model.AC_000186.1.509 Q2KIL8 CK086_BOVIN 100.000 0.98374 1.0082 Uncharacterized protein C11orf86 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000186.1.510 Q8IV01 SYT12_HUMAN 96.437 0.995261 1.00238 SYT12 - Synaptotagmin-12 - Homo sapiens (Human) - SYT12 gene Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (By similarity). Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids (By similarity). Essential for mossy-fiber long-term potentiation in the hippocampus (By similarity). Taurus_UMD|evm.model.AC_000186.1.511 O00212 RHOD_HUMAN 88.571 0.990521 1.00476 RHOD - Rho-related GTP-binding protein RhoD precursor - Homo sapiens (Human) - RHOD gene Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. Taurus_UMD|evm.model.AC_000186.1.513 Q9Y2K7 KDM2A_HUMAN 96.830 0.661228 0.89673 KDM2A - Lysine-specific demethylase 2A - Homo sapiens (Human) - KDM2A gene Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). Taurus_UMD|evm.model.AC_000186.1.514 P21146 ARBK1_BOVIN 98.624 0.496956 1.90711 GRK2 - Beta-adrenergic receptor kinase 1 - Bos taurus (Bovine) - GRK2 gene Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (By similarity). Key regulator of LPAR1 signaling (By similarity). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (By similarity). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (PubMed:21659505). Inhibits relaxation of airway smooth muscle in response to blue light (By similarity). Taurus_UMD|evm.model.AC_000186.1.515 Q5XIS1 SSH3_RAT 81.860 0.995385 0.996933 Ssh3 - Protein phosphatase Slingshot homolog 3 - Rattus norvegicus (Rat) - Ssh3 gene Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity). Taurus_UMD|evm.model.AC_000186.1.516 Q3T0X9 DPOD4_BOVIN 100.000 0.981481 1.00935 POLD4 - DNA polymerase delta subunit 4 - Bos taurus (Bovine) - POLD4 gene As a component of the tetrameric DNA polymerase delta 4 complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb. Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites. Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival. Taurus_UMD|evm.model.AC_000186.1.517 Q9UBD9 CLCF1_HUMAN 93.491 0.827586 0.902222 CLCF1 - Cardiotrophin-like cytokine factor 1 precursor - Homo sapiens (Human) - CLCF1 gene In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor. Taurus_UMD|evm.model.AC_000186.1.518 Q99638 RAD9A_HUMAN 87.848 0.994949 1.01279 RAD9A - Cell cycle checkpoint control protein RAD9A - Homo sapiens (Human) - RAD9A gene Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex. Taurus_UMD|evm.model.AC_000186.1.519 P62138 PP1A_RAT 100.000 0.923333 0.909091 Ppp1ca - Serine/threonine-protein phosphatase PP1-alpha catalytic subunit - Rattus norvegicus (Rat) - Ppp1ca gene Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity). Dephosphorylates CENPA (By similarity). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (By similarity). Taurus_UMD|evm.model.AC_000186.1.520 Q8IV04 TB10C_HUMAN 92.601 0.995526 1.00224 TBC1D10C - Carabin - Homo sapiens (Human) - TBC1D10C gene Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras. Taurus_UMD|evm.model.AC_000186.1.521 A5YM72 CRNS1_HUMAN 87.923 0.864807 1.12696 CARNS1 - Carnosine synthase 1 - Homo sapiens (Human) - CARNS1 gene Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. Taurus_UMD|evm.model.AC_000186.1.522 Q9UBS0 KS6B2_HUMAN 94.639 0.995885 1.0083 RPS6KB2 - Ribosomal protein S6 kinase beta-2 - Homo sapiens (Human) - RPS6KB2 gene Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). Taurus_UMD|evm.model.AC_000186.1.523 Q14761 PTCA_HUMAN 71.359 0.990148 0.985437 PTPRCAP - Protein tyrosine phosphatase receptor type C-associated protein - Homo sapiens (Human) - PTPRCAP gene plasma membrane, defense response Taurus_UMD|evm.model.AC_000186.1.524 Q5NVK4 COR1B_PONAB 92.402 0.925714 1.07362 CORO1B - Coronin-1B - Pongo abelii (Sumatran orangutan) - CORO1B gene Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). Taurus_UMD|evm.model.AC_000186.1.525 Q8TDT2 GP152_HUMAN 77.682 0.995556 0.957447 GPR152 - Probable G-protein coupled receptor 152 - Homo sapiens (Human) - GPR152 gene Orphan receptor. Taurus_UMD|evm.model.AC_000186.1.526 Q8HZJ4 CABP4_BOVIN 100.000 0.992857 1.00358 CABP4 - Calcium-binding protein 4 - Bos taurus (Bovine) - CABP4 gene May play a role in normal synaptic function, probably through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1F, shifting the activation range to more hyperpolarized voltages (By similarity). Taurus_UMD|evm.model.AC_000186.1.527 Q05B54 TM134_BOVIN 100.000 0.989796 1.00513 TMEM134 - Transmembrane protein 134 - Bos taurus (Bovine) - TMEM134 gene Taurus_UMD|evm.model.AC_000186.1.529 Q7YRC1 AIP_BOVIN 97.879 0.993958 1.00303 AIP - AH receptor-interacting protein - Bos taurus (Bovine) - AIP gene May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Taurus_UMD|evm.model.AC_000186.1.530 O00562 PITM1_HUMAN 91.040 0.998401 1.00563 PITPNM1 - Membrane-associated phosphatidylinositol transfer protein 1 - Homo sapiens (Human) - PITPNM1 gene Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:22822086, PubMed:10531358). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). Taurus_UMD|evm.model.AC_000186.1.531 Q58CN7 CDKA2_BOVIN 100.000 0.984375 1.00787 CDK2AP2 - Cyclin-dependent kinase 2-associated protein 2 - Bos taurus (Bovine) - CDK2AP2 gene Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes. Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A. Taurus_UMD|evm.model.AC_000186.1.532 Q9N1Q9 CABP2_BOVIN 100.000 0.534091 1.61963 CABP2 - Calcium-binding protein 2 - Bos taurus (Bovine) - CABP2 gene Required for sound encoding at inner hair cells (IHCs) synapses, likely via inhibition of the inactivation of voltage-gated calcium channel of type 1.3 (Cav1.3) in the IHCs. Required for the normal transfer of light signals through the retina. Taurus_UMD|evm.model.AC_000186.1.533 Q9TTY8 GSTP1_CAPHI 80.583 0.953488 1.02381 GSTP1 - Glutathione S-transferase P - Capra hircus (Goat) - GSTP1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Taurus_UMD|evm.model.AC_000186.1.534 P28801 GSTP1_BOVIN 99.524 0.870833 1.14286 GSTP1 - Glutathione S-transferase P - Bos taurus (Bovine) - GSTP1 gene Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Taurus_UMD|evm.model.AC_000186.1.535 P25708 NDUV1_BOVIN 100.000 0.995699 1.00216 NDUFV1 - NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor - Bos taurus (Bovine) - NDUFV1 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Taurus_UMD|evm.model.AC_000186.1.536 Q9ESN1 DOC2G_MOUSE 72.632 0.990937 0.855297 Doc2g - Double C2-like domain-containing protein gamma - Mus musculus (Mouse) - Doc2g gene May be involved in regulation of vesicular trafficking. In vitro, does not bind calcium and phospholipids. Taurus_UMD|evm.model.AC_000186.1.537 O75333 TBX10_HUMAN 87.267 0.304099 2.72468 TBX10 - T-box transcription factor TBX10 - Homo sapiens (Human) - TBX10 gene Probable transcriptional regulator involved in developmental processes. Taurus_UMD|evm.model.AC_000186.1.538 Q9H1C4 UN93B_HUMAN 91.283 0.996716 1.0201 UNC93B1 - Protein unc-93 homolog B1 - Homo sapiens (Human) - UNC93B1 gene Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. Taurus_UMD|evm.model.AC_000186.1.539 Q1JPA0 AL3B1_BOVIN 100.000 0.903288 1.1047 ALDH3B1 - Aldehyde dehydrogenase family 3 member B1 precursor - Bos taurus (Bovine) - ALDH3B1 gene Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor. May have a protective role against the cytotoxicity induced by lipid peroxidation. Taurus_UMD|evm.model.AC_000186.1.540 P42028 NDUS8_BOVIN 100.000 0.687296 1.44811 NDUFS8 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial precursor - Bos taurus (Bovine) - NDUFS8 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:10852722, PubMed:18721790). Essential for the catalytic activity and assembly of complex I (By similarity). Taurus_UMD|evm.model.AC_000186.1.541 Q13488 VPP3_HUMAN 92.029 0.769663 0.214458 TCIRG1 - V-type proton ATPase 116 kDa subunit a3 - Homo sapiens (Human) - TCIRG1 gene Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation. Taurus_UMD|evm.model.AC_000186.1.542 Q13488 VPP3_HUMAN 86.000 0.832402 0.215663 TCIRG1 - V-type proton ATPase 116 kDa subunit a3 - Homo sapiens (Human) - TCIRG1 gene Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation. Taurus_UMD|evm.model.AC_000186.1.543 Q13488 VPP3_HUMAN 80.571 0.994302 0.422892 TCIRG1 - V-type proton ATPase 116 kDa subunit a3 - Homo sapiens (Human) - TCIRG1 gene Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation. Taurus_UMD|evm.model.AC_000186.1.545 P35790 CHKA_HUMAN 85.523 0.771784 1.0547 CHKA - Choline kinase alpha - Homo sapiens (Human) - CHKA gene Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline. Taurus_UMD|evm.model.AC_000186.1.546 P35790 CHKA_HUMAN 88.034 0.307278 0.811816 CHKA - Choline kinase alpha - Homo sapiens (Human) - CHKA gene Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline. Taurus_UMD|evm.model.AC_000186.1.547 Q29RP8 KMT5B_BOVIN 99.745 0.442308 2.24936 KMT5B - Histone-lysine N-methyltransferase KMT5B - Bos taurus (Bovine) - KMT5B gene Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). Taurus_UMD|evm.model.AC_000186.1.548 Q4V7A5 CK024_RAT 59.615 0.51671 0.815514 Uncharacterized protein C11orf24 homolog precursor - Rattus norvegicus (Rat) Taurus_UMD|evm.model.AC_000186.1.550 P62752 RL23A_RAT 69.298 0.972477 0.698718 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000186.1.551 O75197 LRP5_HUMAN 96.974 0.973587 1.00805 LRP5 - Low-density lipoprotein receptor-related protein 5 precursor - Homo sapiens (Human) - LRP5 gene Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins (PubMed:11336703, PubMed:11448771, PubMed:15778503, PubMed:11719191, PubMed:15908424, PubMed:16252235). Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed:11336703, PubMed:11719191). In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed:11719191). Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs (PubMed:11336703, PubMed:25920554, PubMed:24706814, PubMed:14731402). Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development (PubMed:27228167, PubMed:16252235). Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis (By similarity). Taurus_UMD|evm.model.AC_000186.1.552 Q5H9R7 PP6R3_HUMAN 95.991 0.964602 1.03551 PPP6R3 - Serine/threonine-protein phosphatase 6 regulatory subunit 3 - Homo sapiens (Human) - PPP6R3 gene Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. Taurus_UMD|evm.model.AC_000186.1.553 P11242 GALA_BOVIN 100.000 0.40604 2.42276 GAL - Galanin peptides precursor - Bos taurus (Bovine) - GAL gene Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion. Taurus_UMD|evm.model.AC_000186.1.554 P50416 CPT1A_HUMAN 89.895 0.540867 1.82018 CPT1A - Carnitine O-palmitoyltransferase 1, liver isoform - Homo sapiens (Human) - CPT1A gene Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:9691089, PubMed:11350182, PubMed:14517221). Plays an important role in hepatic triglyceride metabolism (By similarity). Taurus_UMD|evm.model.AC_000186.1.555 Q2TBS2 RM21_BOVIN 99.043 0.990476 1.00478 MRPL21 - 39S ribosomal protein L21, mitochondrial precursor - Bos taurus (Bovine) - MRPL21 gene mitochondrial inner membrane, mitochondrial large ribosomal subunit, structural constituent of ribosome Taurus_UMD|evm.model.AC_000186.1.556 P38935 SMBP2_HUMAN 79.037 0.913246 1.07956 IGHMBP2 - DNA-binding protein SMUBP-2 - Homo sapiens (Human) - IGHMBP2 gene 5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation (By similarity). DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV. Taurus_UMD|evm.model.AC_000186.1.557 Q7TN41 MRGRD_RAT 43.692 0.975155 1.0094 Mrgprd - Mas-related G-protein coupled receptor member D - Rattus norvegicus (Rat) - Mrgprd gene May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. The receptor couples with G-protein G(q) and G(i) (By similarity). Taurus_UMD|evm.model.AC_000186.1.558 Q6L786 MRGRD_MACFA 53.968 0.975 1 MRGPRD - Mas-related G-protein coupled receptor member D - Macaca fascicularis (Crab-eating macaque) - MRGPRD gene May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. The receptor couples with G-protein G(q) and G(i) (By similarity). Taurus_UMD|evm.model.AC_000186.1.559 Q96AM1 MRGRF_HUMAN 89.213 0.994186 1.00292 MRGPRF - Mas-related G-protein coupled receptor member F - Homo sapiens (Human) - MRGPRF gene Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity). Taurus_UMD|evm.model.AC_000186.1.560 Q8NHX9 TPC2_HUMAN 78.220 0.99734 1 TPCN2 - Two pore calcium channel protein 2 - Homo sapiens (Human) - TPCN2 gene Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. Taurus_UMD|evm.model.AC_000186.1.564 Q2KI22 CCND1_BOVIN 100.000 0.993243 1.00339 CCND1 - G1/S-specific cyclin-D1 - Bos taurus (Bovine) - CCND1 gene Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity). Taurus_UMD|evm.model.AC_000186.1.565 Q8WV07 LTO1_HUMAN 89.781 0.985507 1.0073 LTO1 - Protein LTO1 homolog - Homo sapiens (Human) - LTO1 gene The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:23318452). May play a role in the regulation of proline metabolism and ROS production (PubMed:24930674). Taurus_UMD|evm.model.AC_000186.1.566 O95750 FGF19_HUMAN 75.000 0.958904 1.01389 FGF19 - Fibroblast growth factor 19 precursor - Homo sapiens (Human) - FGF19 gene Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. Taurus_UMD|evm.model.AC_000186.1.568 P48803 FGF4_BOVIN 100.000 0.90099 0.490291 FGF4 - Fibroblast growth factor 4 precursor - Bos taurus (Bovine) - FGF4 gene Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). Taurus_UMD|evm.model.AC_000186.1.569 P11487 FGF3_HUMAN 84.834 0.886076 0.991632 FGF3 - Fibroblast growth factor 3 precursor - Homo sapiens (Human) - FGF3 gene Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development. Taurus_UMD|evm.model.AC_000186.1.571 Q8BHY3 ANO1_MOUSE 92.744 0.987448 0.995833 Ano1 - Anoctamin-1 - Mus musculus (Mouse) - Ano1 gene Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction (PubMed:28561733, PubMed:29236691, PubMed:29236684). Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Taurus_UMD|evm.model.AC_000186.1.572 Q645M6 FADD_BOVIN 77.043 0.992248 1.23445 FADD - FAS-associated death domain protein - Bos taurus (Bovine) - FADD gene Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. Taurus_UMD|evm.model.AC_000186.1.573 A3KN12 PUR8_BOVIN 61.570 0.675 0.571429 ADSL - Adenylosuccinate lyase - Bos taurus (Bovine) - ADSL gene Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. Taurus_UMD|evm.model.AC_000186.1.574 Q13136 LIPA1_HUMAN 94.093 0.949407 1.05241 PPFIA1 - Liprin-alpha-1 - Homo sapiens (Human) - PPFIA1 gene May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Taurus_UMD|evm.model.AC_000186.1.576 Q60598 SRC8_MOUSE 88.645 0.996289 0.987179 Cttn - Src substrate cortactin - Mus musculus (Mouse) - Cttn gene Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:17403031). Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (PubMed:22262902). Plays a role in the invasiveness of cancer cells, and the formation of metastases (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (By similarity). Taurus_UMD|evm.model.AC_000186.1.577 Q9UPX8 SHAN2_HUMAN 86.662 0.785363 1.24558 SHANK2 - SH3 and multiple ankyrin repeat domains protein 2 - Homo sapiens (Human) - SHANK2 gene Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. Taurus_UMD|evm.model.AC_000186.1.580 P10995 ACT2_XENLA 50.546 0.978495 0.986737 act2 - Actin, alpha skeletal muscle 2 precursor - Xenopus laevis (African clawed frog) - act2 gene Actins are highly conserved proteins that are involved in various types of cell motility. Taurus_UMD|evm.model.AC_000186.1.581 Q5E9J5 DHCR7_BOVIN 94.526 0.812834 1.18105 DHCR7 - 7-dehydrocholesterol reductase - Bos taurus (Bovine) - DHCR7 gene 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermidiates in that pathway. Taurus_UMD|evm.model.AC_000186.1.582 Q3ZBF0 NADE_BOVIN 100.000 0.997171 1.00142 NADSYN1 - Glutamine-dependent NAD(+) synthetase - Bos taurus (Bovine) - NADSYN1 gene Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. Taurus_UMD|evm.model.AC_000186.1.583 Q4QXU5 MRGX2_MACMU 37.847 0.881789 0.951368 MRGPRX2 - Mas-related G-protein coupled receptor member X2 - Macaca mulatta (Rhesus macaque) - MRGPRX2 gene Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction. Taurus_UMD|evm.model.AC_000186.1.584 Q86SM5 MRGRG_HUMAN 66.316 0.613391 1.60208 MRGPRG - Mas-related G-protein coupled receptor member G - Homo sapiens (Human) - MRGPRG gene Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity). Taurus_UMD|evm.model.AC_000186.1.587 Q9H0X9 OSBL5_HUMAN 87.727 0.967814 1.02503 OSBPL5 - Oxysterol-binding protein-related protein 5 - Homo sapiens (Human) - OSBPL5 gene Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). Taurus_UMD|evm.model.AC_000186.1.588 P83626 TNR26_MOUSE 42.963 0.29955 2.17647 Tnfrsf26 - Tumor necrosis factor receptor superfamily member 26 precursor - Mus musculus (Mouse) - Tnfrsf26 gene cell surface, plasma membrane, positive regulation of apoptotic process, TRAIL-activated apoptotic signaling pathway Taurus_UMD|evm.model.AC_000186.1.589 Q4R550 SYCC_MACFA 84.532 0.883553 1.11364 CARS1 - Cysteine--tRNA ligase, cytoplasmic - Macaca fascicularis (Crab-eating macaque) - CARS1 gene Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys). Taurus_UMD|evm.model.AC_000186.1.590 Q2TA40 NP1L4_BOVIN 99.741 0.910165 1.09585 NAP1L4 - Nucleosome assembly protein 1-like 4 - Bos taurus (Bovine) - NAP1L4 gene Acts as histone chaperone in nucleosome assembly. Taurus_UMD|evm.model.AC_000186.1.592 Q0VC85 PHLA2_BOVIN 99.296 0.986014 1.00704 PHLDA2 - Pleckstrin homology-like domain family A member 2 - Bos taurus (Bovine) - PHLDA2 gene Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). Taurus_UMD|evm.model.AC_000186.1.593 Q96BI1 S22AI_HUMAN 79.009 0.766304 1.30189 SLC22A18 - Solute carrier family 22 member 18 - Homo sapiens (Human) - SLC22A18 gene May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Taurus_UMD|evm.model.AC_000186.1.594 P49918 CDN1C_HUMAN 77.778 0.533865 0.794304 CDKN1C - Cyclin-dependent kinase inhibitor 1C - Homo sapiens (Human) - CDKN1C gene Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. Taurus_UMD|evm.model.AC_000186.1.595 Q9TTJ7 KCNQ1_PIG 87.081 0.990476 0.312036 KCNQ1 - Potassium voltage-gated channel subfamily KQT member 1 - Sus scrofa (Pig) - KCNQ1 gene Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (By similarity). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (By similarity). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). When associated with KCNE4, inhibits voltage-gated potassium channel activity (By similarity). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (By similarity). Also forms a heterotetramer with KCNQ5 that has a voltage-gated potassium channel activity (By similarity). Binds with phosphatidylinositol 4,5-bisphosphate (By similarity). Taurus_UMD|evm.model.AC_000186.1.596 O97531 KCNQ1_FELCA 100.000 0.312 0.214777 KCNQ1 - Potassium voltage-gated channel subfamily KQT member 1 - Felis catus (Cat) - KCNQ1 gene Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (By similarity). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (By similarity). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). When associated with KCNE4, inhibits voltage-gated potassium channel activity (By similarity). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (By similarity). Also forms a heterotetramer with KCNQ5 that has a voltage-gated potassium channel activity (By similarity). Binds with phosphatidylinositol 4,5-bisphosphate (By similarity). Taurus_UMD|evm.model.AC_000186.1.597 Q9NZQ8 TRPM5_HUMAN 78.780 0.997278 0.945923 TRPM5 - Transient receptor potential cation channel subfamily M member 5 - Homo sapiens (Human) - TRPM5 gene Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals. Taurus_UMD|evm.model.AC_000186.1.598 Q1LZD3 TSSC4_BOVIN 100.000 0.993865 1.00308 TSSC4 - Protein TSSC4 - Bos taurus (Bovine) - TSSC4 gene Taurus_UMD|evm.model.AC_000186.1.599 Q3ZCD0 CD81_BOVIN 100.000 0.726962 1.24153 CD81 - CD81 antigen - Bos taurus (Bovine) - CD81 gene Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype. Present in MHC class II compartments, may also play a role in antigen presentation (By similarity). Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. Positively regulates sperm-egg fusion and may be involved in acrosome reaction. In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). May regulate the compartmentalization of enzymatic activities. In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels (By similarity). Also involved in cell adhesion and motility. Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung (By similarity). Taurus_UMD|evm.model.AC_000186.1.600 Q96QS1 TSN32_HUMAN 55.056 0.809375 1 TSPAN32 - Tetraspanin-32 - Homo sapiens (Human) - TSPAN32 gene integral component of plasma membrane, cell-cell signaling, protein localization to plasma membrane, protein maturation Taurus_UMD|evm.model.AC_000186.1.601 Q2EGB9 ASCL2_BOVIN 100.000 0.989691 1.00518 ASCL2 - Achaete-scute homolog 2 - Bos taurus (Bovine) - ASCL2 gene AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Taurus_UMD|evm.model.AC_000186.1.603 P17289 TY3H_BOVIN 97.963 0.995935 1.00204 TH - Tyrosine 3-monooxygenase - Bos taurus (Bovine) - TH gene Plays an important role in the physiology of adrenergic neurons (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). Taurus_UMD|evm.model.AC_000186.1.604 P01318 INS_SHEEP 97.143 0.468468 2.11429 INS - Insulin precursor - Ovis aries (Sheep) - INS gene Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Taurus_UMD|evm.model.AC_000186.1.605 P07456 IGF2_BOVIN 100.000 0.754237 1.31844 IGF2 - Insulin-like growth factor II precursor - Bos taurus (Bovine) - IGF2 gene The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity). Taurus_UMD|evm.model.AC_000186.1.609 Q16540 RM23_HUMAN 83.486 0.981651 0.712418 MRPL23 - 39S ribosomal protein L23, mitochondrial - Homo sapiens (Human) - MRPL23 gene fibrillar center, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, RNA binding, structural constituent of ribosome, mitochondrial translation, mitochondrial translational elongation, mitochondrial translational termination, translation Taurus_UMD|evm.model.AC_000186.1.610 Q8MKI3 TNNT3_BOVIN 98.155 0.849359 1.15129 Tnnt3 - Troponin T, fast skeletal muscle - Bos taurus (Bovine) - Tnnt3 gene Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Taurus_UMD|evm.model.AC_000186.1.611 Q8C494 PRR33_MOUSE 57.634 0.488722 2.04615 Prr33 - Proline-rich protein 33 - Mus musculus (Mouse) - Prr33 gene response to wounding Taurus_UMD|evm.model.AC_000186.1.612 P33241 LSP1_HUMAN 67.308 0.994505 1.07375 LSP1 - Lymphocyte-specific protein 1 - Homo sapiens (Human) - LSP1 gene May play a role in mediating neutrophil activation and chemotaxis. Taurus_UMD|evm.model.AC_000186.1.613 P02643 TNNI2_RABIT 95.604 0.363454 2.73626 TNNI2 - Troponin I, fast skeletal muscle - Oryctolagus cuniculus (Rabbit) - TNNI2 gene Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Taurus_UMD|evm.model.AC_000186.1.614 P80209 CATD_BOVIN 98.462 0.941889 1.05897 CTSD - Cathepsin D precursor - Bos taurus (Bovine) - CTSD gene Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Taurus_UMD|evm.model.AC_000186.1.615 Q9HC73 CRLF2_HUMAN 56.349 0.946154 1.05121 CRLF2 - Cytokine receptor-like factor 2 precursor - Homo sapiens (Human) - CRLF2 gene Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. Taurus_UMD|evm.model.AC_000186.1.616 Q6W4X9 MUC6_HUMAN 59.574 0.413333 0.0922509 MUC6 - Mucin-6 precursor - Homo sapiens (Human) - MUC6 gene May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. Taurus_UMD|evm.model.AC_000186.1.617 Q0VCK5 AP2A2_BOVIN 97.966 0.976963 1.01812 AP2A2 - AP-2 complex subunit alpha-2 - Bos taurus (Bovine) - AP2A2 gene Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). Taurus_UMD|evm.model.AC_000186.1.618 Q5EAB4 CHID1_BOVIN 100.000 0.994924 1.00254 CHID1 - Chitinase domain-containing protein 1 precursor - Bos taurus (Bovine) - CHID1 gene Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity). Taurus_UMD|evm.model.AC_000186.1.619 Q5RAP3 TSN4_PONAB 93.277 0.759615 1.31092 TSPAN4 - Tetraspanin-4 - Pongo abelii (Sumatran orangutan) - TSPAN4 gene Taurus_UMD|evm.model.AC_000186.1.621 P70582 NUP54_RAT 97.727 0.850649 0.301961 Nup54 - Nuclear pore complex protein Nup54 - Rattus norvegicus (Rat) - Nup54 gene Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. Taurus_UMD|evm.model.AC_000186.1.624 P62876 RPAB5_MOUSE 100.000 0.970588 1.01493 Polr2l - DNA-directed RNA polymerases I, II, and III subunit RPABC5 - Mus musculus (Mouse) - Polr2l gene DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity). Taurus_UMD|evm.model.AC_000186.1.625 Q3ZBH3 CD151_BOVIN 100.000 0.992126 1.00395 CD151 - CD151 antigen - Bos taurus (Bovine) - CD151 gene Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. Taurus_UMD|evm.model.AC_000186.1.626 Q80ZJ8 EFC4A_MOUSE 64.785 0.916667 0.883249 Cracr2b - EF-hand calcium-binding domain-containing protein 4A - Mus musculus (Mouse) - Cracr2b gene Plays a role in store-operated Ca(2+) entry (SOCE). Taurus_UMD|evm.model.AC_000186.1.627 Q2KI18 PLPL2_BOVIN 99.794 0.995893 1.00206 PNPLA2 - Patatin-like phospholipase domain-containing protein 2 - Bos taurus (Bovine) - PNPLA2 gene Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone. Also has acylglycerol transacylase activity. Acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides. Regulates adiposome size and may be involved in the degradation of adiposomes (By similarity). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity). Taurus_UMD|evm.model.AC_000186.1.628 O88450 DEAF1_RAT 86.916 0.981481 0.19115 Deaf1 - Deformed epidermal autoregulatory factor 1 homolog - Rattus norvegicus (Rat) - Deaf1 gene Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Transcriptional activator of EIF4G3. May also involved in behavior (By similarity). Taurus_UMD|evm.model.AC_000186.1.629 P42899 RLA2_BOVIN 100.000 0.982759 1.0087 RPLP2 - 60S acidic ribosomal protein P2 - Bos taurus (Bovine) - RPLP2 gene Plays an important role in the elongation step of protein synthesis. Taurus_UMD|evm.model.AC_000186.1.630 Q9HB75 PIDD1_HUMAN 82.037 0.997812 1.0044 PIDD1 - p53-induced death domain-containing protein 1 - Homo sapiens (Human) - PIDD1 gene Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264, PubMed:15073321, PubMed:16360037, PubMed:17159900). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:17159900). Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (PubMed:16360037, PubMed:17159900). Taurus_UMD|evm.model.AC_000186.1.631 Q6TLJ0 DRD4_MUSPF 86.957 0.636364 0.40056 DRD4 - D(4) dopamine receptor - Mustela putorius furo (European domestic ferret) - DRD4 gene Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs. Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells. Taurus_UMD|evm.model.AC_000186.1.632 P63298 SECR_PIG 100.000 0.508197 0.455224 SCT - Secretin precursor - Sus scrofa (Pig) - SCT gene Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity). Taurus_UMD|evm.model.AC_000186.1.636 Q08DK4 GHC1_BOVIN 100.000 0.993808 1.00311 SLC25A22 - Mitochondrial glutamate carrier 1 - Bos taurus (Bovine) - SLC25A22 gene Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+) (By similarity). Taurus_UMD|evm.model.AC_000186.1.637 Q29026 CEND_PIG 78.912 0.986395 1.05 CEND1 - Cell cycle exit and neuronal differentiation protein 1 - Sus scrofa (Pig) - CEND1 gene Involved in neuronal differentiation. Taurus_UMD|evm.model.AC_000186.1.638 Q29RZ1 GALD1_BOVIN 100.000 0.99095 1.00455 GATD1 - Glutamine amidotransferase-like class 1 domain-containing protein 1 precursor - Bos taurus (Bovine) - GATD1 gene Taurus_UMD|evm.model.AC_000186.1.639 Q2TBL6 TALDO_BOVIN 99.703 0.994083 1.00297 TALDO1 - Transaldolase - Bos taurus (Bovine) - TALDO1 gene Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Taurus_UMD|evm.model.AC_000186.1.640 Q5RC07 ES8L2_PONAB 81.429 0.932432 0.103352 EPS8L2 - Epidermal growth factor receptor kinase substrate 8-like protein 2 - Pongo abelii (Sumatran orangutan) - EPS8L2 gene Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). Taurus_UMD|evm.model.AC_000186.1.641 P63298 SECR_PIG 96.875 0.43662 0.529851 SCT - Secretin precursor - Sus scrofa (Pig) - SCT gene Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity). Taurus_UMD|evm.model.AC_000186.1.642 Q13202 DUS8_HUMAN 96.154 0.175048 1.6544 DUSP8 - Dual specificity protein phosphatase 8 - Homo sapiens (Human) - DUSP8 gene Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues. Taurus_UMD|evm.model.AC_000186.1.643 Q92985 IRF7_HUMAN 62.075 0.995842 0.956262 IRF7 - Interferon regulatory factor 7 - Homo sapiens (Human) - IRF7 gene Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:17574024, PubMed:32972995). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity) (PubMed:11073981, PubMed:12374802, PubMed:15361868, PubMed:17404045). Taurus_UMD|evm.model.AC_000186.1.644 Q5RC07 ES8L2_PONAB 86.462 0.237215 3.25 EPS8L2 - Epidermal growth factor receptor kinase substrate 8-like protein 2 - Pongo abelii (Sumatran orangutan) - EPS8L2 gene Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). Taurus_UMD|evm.model.AC_000186.1.646 A1A4P6 TMM80_BOVIN 100.000 0.986111 1.00699 TMEM80 - Transmembrane protein 80 - Bos taurus (Bovine) - TMEM80 gene ciliary transition zone, non-motile cilium assembly Taurus_UMD|evm.model.AC_000186.1.647 O75398 DEAF1_HUMAN 94.389 0.993421 0.538053 DEAF1 - Deformed epidermal autoregulatory factor 1 homolog - Homo sapiens (Human) - DEAF1 gene Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. Taurus_UMD|evm.model.AC_000186.1.648 Q8IWQ3 BRSK2_HUMAN 94.611 0.983776 0.921196 BRSK2 - Serine/threonine-protein kinase BRSK2 - Homo sapiens (Human) - BRSK2 gene Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. Taurus_UMD|evm.model.AC_000186.1.649 Q8IXW0 LMTD2_HUMAN 51.671 0.941919 0.624606 LMNTD2 - Lamin tail domain-containing protein 2 - Homo sapiens (Human) - LMNTD2 gene Taurus_UMD|evm.model.AC_000186.1.650 Q8IYG6 LRC56_HUMAN 67.500 0.957328 0.994465 LRRC56 - Leucine-rich repeat-containing protein 56 - Homo sapiens (Human) - LRRC56 gene Required for the assembly of dynein arms. Taurus_UMD|evm.model.AC_000186.1.651 P20171 RASH_RAT 95.767 0.989474 1.00529 Hras - GTPase HRas precursor - Rattus norvegicus (Rat) - Hras gene Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Taurus_UMD|evm.model.AC_000186.1.652 Q9Z1X2 PTSS2_MOUSE 97.321 0.529691 0.890063 Ptdss2 - Phosphatidylserine synthase 2 - Mus musculus (Mouse) - Ptdss2 gene Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:10432300, PubMed:10938271, PubMed:23071296, PubMed:12361952). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (PubMed:10938271, PubMed:23071296). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (PubMed:23071296). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (PubMed:23071296). Taurus_UMD|evm.model.AC_000186.1.653 O08888 PTSS2_CRIGR 80.000 0.892562 0.255274 PTDSS2 - Phosphatidylserine synthase 2 - Cricetulus griseus (Chinese hamster) - PTDSS2 gene Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:12912985, PubMed:9235902). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (PubMed:12912985, PubMed:9235902). Shows a substrate specificity for phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity). Taurus_UMD|evm.model.AC_000186.1.654 Q6IA17 SIGIR_HUMAN 83.902 0.410231 2.43171 SIGIRR - Single Ig IL-1-related receptor - Homo sapiens (Human) - SIGIRR gene Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. Taurus_UMD|evm.model.AC_000186.1.655 Q08DQ0 PKP3_BOVIN 100.000 0.997481 1.00126 PKP3 - Plakophilin-3 - Bos taurus (Bovine) - PKP3 gene May play a role in junctional plaques. Taurus_UMD|evm.model.AC_000186.1.656 Q76KP1 B4GN4_HUMAN 84.394 0.838643 0.936477 B4GALNT4 - N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 - Homo sapiens (Human) - B4GALNT4 gene Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Taurus_UMD|evm.model.AC_000186.1.657 C9JQL5 DSA2D_HUMAN 70.370 0.727891 1.10526 Putative dispanin subfamily A member 2d - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000186.1.658 Q9HC84 MUC5B_HUMAN 65.770 0.901774 0.127213 MUC5B - Mucin-5B precursor - Homo sapiens (Human) - MUC5B gene Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. Taurus_UMD|evm.model.AC_000186.1.662 Q9HC84 MUC5B_HUMAN 66.704 0.361484 0.81378 MUC5B - Mucin-5B precursor - Homo sapiens (Human) - MUC5B gene Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. Taurus_UMD|evm.model.AC_000186.1.663 P98088 MUC5A_HUMAN 71.090 0.398423 0.650336 MUC5AC - Mucin-5AC precursor - Homo sapiens (Human) - MUC5AC gene Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). Taurus_UMD|evm.model.AC_000186.1.664 Q02817 MUC2_HUMAN 68.103 0.904 0.0241359 MUC2 - Mucin-2 precursor - Homo sapiens (Human) - MUC2 gene Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. Taurus_UMD|evm.model.AC_000187.1.1 Q8BHN1 TXLNG_MOUSE 94.118 0.706806 0.364504 Txlng - Gamma-taxilin - Mus musculus (Mouse) - Txlng gene May be involved in intracellular vesicle traffic (By similarity). Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. Taurus_UMD|evm.model.AC_000187.1.2 Q8NDT2 RB15B_HUMAN 78.750 0.868132 0.102247 RBM15B - Putative RNA-binding protein 15B - Homo sapiens (Human) - RBM15B gene RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). Taurus_UMD|evm.model.AC_000187.1.3 P82197 PDXK_SHEEP 56.338 0.842593 0.346154 PDXK - Pyridoxal kinase - Ovis aries (Sheep) - PDXK gene Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (PubMed:14722069) (By similarity). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity). Taurus_UMD|evm.model.AC_000187.1.4 Q4R717 KKLC1_MACFA 64.348 0.933884 1.0614 CT83 - Kita-kyushu lung cancer antigen 1 homolog - Macaca fascicularis (Crab-eating macaque) - CT83 gene Taurus_UMD|evm.model.AC_000187.1.5 Q9UN76 S6A14_HUMAN 86.625 0.99688 0.998442 SLC6A14 - Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) - Homo sapiens (Human) - SLC6A14 gene Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner. Taurus_UMD|evm.model.AC_000187.1.6 Q28929 AGTR2_SHEEP 98.077 0.713499 1.39615 AGTR2 - Type-2 angiotensin II receptor - Ovis aries (Sheep) - AGTR2 gene Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (By similarity). Taurus_UMD|evm.model.AC_000187.1.7 O19110 TSPY1_BOVIN 38.158 0.954248 0.48265 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000187.1.8 Q9C0H6 KLHL4_HUMAN 77.857 0.978723 0.196379 KLHL4 - Kelch-like protein 4 - Homo sapiens (Human) - KLHL4 gene centriolar satellite, cytoplasm, microtubule cytoskeleton Taurus_UMD|evm.model.AC_000187.1.9 Q9C0H6 KLHL4_HUMAN 92.829 0.994036 0.700557 KLHL4 - Kelch-like protein 4 - Homo sapiens (Human) - KLHL4 gene centriolar satellite, cytoplasm, microtubule cytoskeleton Taurus_UMD|evm.model.AC_000187.1.10 A6QQY2 KLH13_BOVIN 99.829 0.693128 1.28855 KLHL13 - Kelch-like protein 13 - Bos taurus (Bovine) - KLHL13 gene Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity). Taurus_UMD|evm.model.AC_000187.1.11 Q3T013 BNI3L_BOVIN 94.366 0.958333 0.328767 BNIP3L - BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like - Bos taurus (Bovine) - BNIP3L gene Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May function as a tumor suppressor (By similarity). Taurus_UMD|evm.model.AC_000187.1.12 Q9XSC3 WDR44_BOVIN 97.368 0.997768 0.982456 WDR44 - WD repeat-containing protein 44 - Bos taurus (Bovine) - WDR44 gene Downstream effector for RAB11. May be involved in vesicle recycling. Taurus_UMD|evm.model.AC_000187.1.13 Q5JSL3 DOC11_HUMAN 97.056 0.997821 0.442836 DOCK11 - Dedicator of cytokinesis protein 11 - Homo sapiens (Human) - DOCK11 gene Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42. Taurus_UMD|evm.model.AC_000187.1.14 P78552 I13R1_HUMAN 95.652 0.535714 0.196721 IL13RA1 - Interleukin-13 receptor subunit alpha-1 precursor - Homo sapiens (Human) - IL13RA1 gene Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. Taurus_UMD|evm.model.AC_000187.1.15 P78552 I13R1_HUMAN 84.553 0.99455 0.859485 IL13RA1 - Interleukin-13 receptor subunit alpha-1 precursor - Homo sapiens (Human) - IL13RA1 gene Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. Taurus_UMD|evm.model.AC_000187.1.18 Q08DL1 ZCH12_BOVIN 100.000 0.995037 1.00249 ZCCHC12 - Zinc finger CCHC domain-containing protein 12 - Bos taurus (Bovine) - ZCCHC12 gene Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity). Taurus_UMD|evm.model.AC_000187.1.19 Q496Y0 LONF3_HUMAN 87.237 0.997368 1.00132 LONRF3 - LON peptidase N-terminal domain and RING finger protein 3 - Homo sapiens (Human) - LONRF3 gene Taurus_UMD|evm.model.AC_000187.1.20 Q5JQC4 CT47A_HUMAN 33.333 0.311024 0.881944 CT47A1 - Cancer/testis antigen 47A - Homo sapiens (Human) - CT47A1 gene Taurus_UMD|evm.model.AC_000187.1.21 E9Q0C6 K1210_MOUSE 51.724 0.0328638 1.04093 Kiaa1210 - Acrosomal protein KIAA1210 - Mus musculus (Mouse) - Kiaa1210 gene acrosomal vesicle Taurus_UMD|evm.model.AC_000187.1.22 Q17QC0 PGRC1_BOVIN 99.485 0.989744 1.00515 PGRMC1 - Membrane-associated progesterone receptor component 1 - Bos taurus (Bovine) - PGRMC1 gene Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. Taurus_UMD|evm.model.AC_000187.1.23 Q96I51 RCC1L_HUMAN 81.818 0.030303 2.27586 RCC1L - RCC1-like G exchanging factor-like protein precursor - Homo sapiens (Human) - RCC1L gene Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion (PubMed:28746876). Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system (PubMed:27667664). Taurus_UMD|evm.model.AC_000187.1.24 Q8NDT2 RB15B_HUMAN 95.909 0.784946 0.313483 RBM15B - Putative RNA-binding protein 15B - Homo sapiens (Human) - RBM15B gene RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). Taurus_UMD|evm.model.AC_000187.1.25 Q8WUT9 S2543_HUMAN 80.665 0.959596 0.870968 SLC25A43 - Solute carrier family 25 member 43 - Homo sapiens (Human) - SLC25A43 gene Taurus_UMD|evm.model.AC_000187.1.26 Q8SQH5 ADT2_BOVIN 100.000 0.993311 1.00336 SLC25A5 - ADP/ATP translocase 2 - Bos taurus (Bovine) - SLC25A5 gene ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A5/ANT2 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Probably mediates mitochondrial uncoupling in tissues that do not express UCP1. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A5/ANT2 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity). Taurus_UMD|evm.model.AC_000187.1.27 Q3T197 STEEP_BOVIN 100.000 0.991031 1.0045 STEEP1 - STING ER exit protein - Bos taurus (Bovine) - STEEP1 gene Stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (By similarity). Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers (By similarity). Taurus_UMD|evm.model.AC_000187.1.28 Q9Z255 UBE2A_MOUSE 100.000 0.986928 1.00658 Ube2a - Ubiquitin-conjugating enzyme E2 A - Mus musculus (Mouse) - Ube2a gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Taurus_UMD|evm.model.AC_000187.1.29 O15226 NKRF_HUMAN 96.377 0.877707 1.13768 NKRF - NF-kappa-B-repressing factor - Homo sapiens (Human) - NKRF gene Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. Taurus_UMD|evm.model.AC_000187.1.30 Q3SZN0 SEPT6_BOVIN 100.000 0.990698 1.00703 SEPTIN6 - Septin-6 - Bos taurus (Bovine) - SEPTIN6 gene Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Taurus_UMD|evm.model.AC_000187.1.33 A6NJG2 SWAHD_HUMAN 73.913 0.993769 1.01905 SOWAHD - Ankyrin repeat domain-containing protein SOWAHD - Homo sapiens (Human) - SOWAHD gene Taurus_UMD|evm.model.AC_000187.1.34 Q5R9C3 GPBL1_PONAB 88.095 0.878947 0.400844 GPBP1L1 - Vasculin-like protein 1 - Pongo abelii (Sumatran orangutan) - GPBP1L1 gene Possible transcription factor. Taurus_UMD|evm.model.AC_000187.1.35 Q9BZI7 REN3B_HUMAN 92.961 0.995754 0.975155 UPF3B - Regulator of nonsense transcripts 3B - Homo sapiens (Human) - UPF3B gene Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. Taurus_UMD|evm.model.AC_000187.1.36 Q3SZ63 NOP56_BOVIN 82.927 0.736364 0.184564 NOP56 - Nucleolar protein 56 - Bos taurus (Bovine) - NOP56 gene Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). Taurus_UMD|evm.model.AC_000187.1.37 Q91XL9 OSBL1_MOUSE 77.961 0.896373 0.406316 Osbpl1a - Oxysterol-binding protein-related protein 1 - Mus musculus (Mouse) - Osbpl1a gene Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol. Taurus_UMD|evm.model.AC_000187.1.38 Q67ER4 R113A_BOVIN 99.708 0.753304 1.32362 RNF113A - E3 ubiquitin-protein ligase RNF113A - Bos taurus (Bovine) - RNF113A gene Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling. Taurus_UMD|evm.model.AC_000187.1.39 O35817 AKA14_RAT 57.895 0.740196 0.406375 Akap14 - A-kinase anchor protein 14 - Rattus norvegicus (Rat) - Akap14 gene Binds to type II regulatory subunits of protein kinase A and anchors/targets them. Taurus_UMD|evm.model.AC_000187.1.40 Q9D0F4 NKAP_MOUSE 91.847 0.995215 1.00723 Nkap - NF-kappa-B-activating protein - Mus musculus (Mouse) - Nkap gene Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter (By similarity). Taurus_UMD|evm.model.AC_000187.1.41 Q8NHV9 RHXF1_HUMAN 49.091 0.343949 0.853261 RHOXF1 - Rhox homeobox family member 1 - Homo sapiens (Human) - RHOXF1 gene Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis. Taurus_UMD|evm.model.AC_000187.1.42 O42115 ARX_DANRE 55.882 0.338384 0.437086 arx - Aristaless-related homeobox protein - Danio rerio (Zebrafish) - arx gene Appears to be indispensable for the central nervous system development. May have a role in the neuronal differentiation of the ganglionic eminence and ventral thalamus. May also be involved in axonal guidance in the floor plate. Taurus_UMD|evm.model.AC_000187.1.43 Q5CZC0 FSIP2_HUMAN 46.733 0.887825 0.423339 FSIP2 - Fibrous sheath-interacting protein 2 - Homo sapiens (Human) - FSIP2 gene Plays a role in spermatogenesis. Taurus_UMD|evm.model.AC_000187.1.46 Q5JQC4 CT47A_HUMAN 44.304 0.107246 2.39583 CT47A1 - Cancer/testis antigen 47A - Homo sapiens (Human) - CT47A1 gene Taurus_UMD|evm.model.AC_000187.1.47 Q5JQC4 CT47A_HUMAN 36.054 0.432056 0.996528 CT47A1 - Cancer/testis antigen 47A - Homo sapiens (Human) - CT47A1 gene Taurus_UMD|evm.model.AC_000187.1.49 Q3SX46 C1GLC_BOVIN 100.000 0.99373 1.00314 C1GALT1C1 - C1GALT1-specific chaperone 1 - Bos taurus (Bovine) - C1GALT1C1 gene Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) (By similarity). Taurus_UMD|evm.model.AC_000187.1.50 Q4G009 MCTS1_RAT 99.451 0.989071 1.00549 Mcts1 - Malignant T-cell-amplified sequence 1 - Rattus norvegicus (Rat) - Mcts1 gene Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3 (By similarity). Taurus_UMD|evm.model.AC_000187.1.51 Q13620 CUL4B_HUMAN 96.233 0.997847 1.01752 CUL4B - Cullin-4B - Homo sapiens (Human) - CUL4B gene Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8. With CUL4A, contributes to ribosome biogenesis (PubMed:26711351). Taurus_UMD|evm.model.AC_000187.1.52 P13473 LAMP2_HUMAN 74.939 0.891832 1.10488 LAMP2 - Lysosome-associated membrane glycoprotein 2 precursor - Homo sapiens (Human) - LAMP2 gene Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820). Taurus_UMD|evm.model.AC_000187.1.53 A0A0J9YY54 TX13D_HUMAN 45.183 0.867069 0.463585 TEX13D - Testis-expressed protein 13D - Homo sapiens (Human) - TEX13D gene Taurus_UMD|evm.model.AC_000187.1.54 A7MB71 AT1B4_BOVIN 100.000 0.974504 0.994366 ATP1B4 - Protein ATP1B4 - Bos taurus (Bovine) - ATP1B4 gene May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity). Taurus_UMD|evm.model.AC_000187.1.55 Q5JRV8 T255A_HUMAN 91.404 0.993865 0.934097 TMEM255A - Transmembrane protein 255A - Homo sapiens (Human) - TMEM255A gene Taurus_UMD|evm.model.AC_000187.1.56 Q86T24 KAISO_HUMAN 92.560 0.996997 0.991071 ZBTB33 - Transcriptional regulator Kaiso - Homo sapiens (Human) - ZBTB33 gene Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453). Taurus_UMD|evm.model.AC_000187.1.58 A6NNA5 DRGX_HUMAN 53.968 0.200647 1.1749 DRGX - Dorsal root ganglia homeobox protein - Homo sapiens (Human) - DRGX gene Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain. Taurus_UMD|evm.model.AC_000187.1.59 Q32KN9 PRLD1_BOVIN 62.500 0.907563 0.543379 PRELID1 - PRELI domain-containing protein 1, mitochondrial precursor - Bos taurus (Bovine) - PRELID1 gene Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs (By similarity). Taurus_UMD|evm.model.AC_000187.1.61 Q7ZWF0 RAE1L_DANRE 52.000 0.311881 0.548913 rae1 - mRNA export factor - Danio rerio (Zebrafish) - rae1 gene Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Taurus_UMD|evm.model.AC_000187.1.62 Q9Z2W9 GRIA3_MOUSE 99.132 0.982906 0.922297 Gria3 - Glutamate receptor 3 precursor - Mus musculus (Mouse) - Gria3 gene Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). Taurus_UMD|evm.model.AC_000187.1.63 B2KI97 THOC2_RHIFE 98.717 0.972534 1.0165 THOC2 - THO complex subunit 2 - Rhinolophus ferrumequinum (Greater horseshoe bat) - THOC2 gene Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Plays a role for proper neuronal development. Taurus_UMD|evm.model.AC_000187.1.64 P98170 XIAP_HUMAN 87.726 0.995984 1.00201 XIAP - E3 ubiquitin-protein ligase XIAP - Homo sapiens (Human) - XIAP gene Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program. Taurus_UMD|evm.model.AC_000187.1.65 Q8N3U4 STAG2_HUMAN 96.451 0.998421 1.02924 STAG2 - Cohesin subunit SA-2 - Homo sapiens (Human) - STAG2 gene Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Taurus_UMD|evm.model.AC_000187.1.66 P79103 RS4_BOVIN 91.875 0.868852 0.695817 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000187.1.67 E9Q6I0 V2116_MOUSE 67.241 0.532407 0.252336 Vmn2r116 - Vomeronasal type-2 receptor 116 precursor - Mus musculus (Mouse) - Vmn2r116 gene Receptor for the Esp1 pheromone. Mediates the response to Esp1 which enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation. Taurus_UMD|evm.model.AC_000187.1.68 Q8IYD1 ERF3B_HUMAN 96.659 0.995556 0.716561 GSPT2 - Eukaryotic peptide chain release factor GTP-binding subunit ERF3B - Homo sapiens (Human) - GSPT2 gene Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Taurus_UMD|evm.model.AC_000187.1.69 Q5R4B3 ERF3B_PONAB 62.887 0.975309 0.128981 GSPT2 - Eukaryotic peptide chain release factor GTP-binding subunit ERF3B - Pongo abelii (Sumatran orangutan) - GSPT2 gene Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Taurus_UMD|evm.model.AC_000187.1.70 Q3ZBB1 SH21A_BOVIN 100.000 0.436426 2.27344 SH2D1A - SH2 domain-containing protein 1A - Bos taurus (Bovine) - SH2D1A gene Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 (By similarity). Taurus_UMD|evm.model.AC_000187.1.71 Q9UKZ4 TEN1_HUMAN 96.902 0.995222 0.844771 TENM1 - Teneurin-1 - Homo sapiens (Human) - TENM1 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). Taurus_UMD|evm.model.AC_000187.1.72 Q3SZQ6 RL32_BOVIN 60.741 0.664596 1.19259 RPL32 - 60S ribosomal protein L32 - Bos taurus (Bovine) - RPL32 gene cytosolic large ribosomal subunit Taurus_UMD|evm.model.AC_000187.1.73 Q9WTS4 TEN1_MOUSE 96.552 0.623188 0.0505309 Tenm1 - Teneurin-1 - Mus musculus (Mouse) - Tenm1 gene Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). Taurus_UMD|evm.model.AC_000187.1.75 P23196 APEX1_BOVIN 91.623 0.964467 0.619497 APEX1 - DNA-(apurinic or apyrimidinic site) endonuclease - Bos taurus (Bovine) - APEX1 gene Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA (By similarity). Taurus_UMD|evm.model.AC_000187.1.76 A0A0J9YWL9 TX13C_HUMAN 46.852 0.901857 0.759315 TEX13C - Putative testis-expressed protein 13C - Homo sapiens (Human) - TEX13C gene Taurus_UMD|evm.model.AC_000187.1.81 P08792 RL25_CYBJA 65.278 0.682692 0.732394 RPL25 - 60S ribosomal protein L25 - Cyberlindnera jadinii (Torula yeast) - RPL25 gene This protein binds to a specific region on the 26S rRNA. Taurus_UMD|evm.model.AC_000187.1.82 Q5VW00 DC122_HUMAN 85.511 0.851927 1.06479 DCAF12L2 - DDB1- and CUL4-associated factor 12-like protein 2 - Homo sapiens (Human) - DCAF12L2 gene Cul4-RING E3 ubiquitin ligase complex Taurus_UMD|evm.model.AC_000187.1.83 Q5VW00 DC122_HUMAN 75.120 0.99284 0.904968 DCAF12L2 - DDB1- and CUL4-associated factor 12-like protein 2 - Homo sapiens (Human) - DCAF12L2 gene Cul4-RING E3 ubiquitin ligase complex Taurus_UMD|evm.model.AC_000187.1.84 Q5F3R7 DCA12_CHICK 70.192 0.110753 2.17799 DCAF12 - DDB1- and CUL4-associated factor 12 - Gallus gallus (Chicken) - DCAF12 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Taurus_UMD|evm.model.AC_000187.1.85 Q5VW00 DC122_HUMAN 78.037 0.872951 0.526998 DCAF12L2 - DDB1- and CUL4-associated factor 12-like protein 2 - Homo sapiens (Human) - DCAF12L2 gene Cul4-RING E3 ubiquitin ligase complex Taurus_UMD|evm.model.AC_000187.1.86 Q5JUK9 PAGE3_HUMAN 46.237 0.793103 1.02655 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Taurus_UMD|evm.model.AC_000187.1.87 O43422 P52K_HUMAN 96.667 0.986755 0.198423 THAP12 - 52 kDa repressor of the inhibitor of the protein kinase - Homo sapiens (Human) - THAP12 gene Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. Taurus_UMD|evm.model.AC_000187.1.88 O43422 P52K_HUMAN 92.969 0.994141 0.672799 THAP12 - 52 kDa repressor of the inhibitor of the protein kinase - Homo sapiens (Human) - THAP12 gene Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. Taurus_UMD|evm.model.AC_000187.1.89 Q5JUK9 PAGE3_HUMAN 51.429 0.858333 1.06195 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Taurus_UMD|evm.model.AC_000187.1.90 Q8WWM1 XAGE5_HUMAN 41.000 0.568966 1.61111 XAGE5 - X antigen family member 5 - Homo sapiens (Human) - XAGE5 gene Taurus_UMD|evm.model.AC_000187.1.91 A5PJK7 PRR32_BOVIN 100.000 0.993243 1.00339 PRR32 - Proline-rich protein 32 - Bos taurus (Bovine) - PRR32 gene Taurus_UMD|evm.model.AC_000187.1.92 Q9UBU8 MO4L1_HUMAN 53.535 0.289562 0.820442 MORF4L1 - Mortality factor 4-like protein 1 - Homo sapiens (Human) - MORF4L1 gene Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. Taurus_UMD|evm.model.AC_000187.1.94 Q8IU81 I2BP1_HUMAN 95.357 0.877165 1.08733 IRF2BP1 - Interferon regulatory factor 2-binding protein 1 - Homo sapiens (Human) - IRF2BP1 gene Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. Taurus_UMD|evm.model.AC_000187.1.96 Q8TDG2 ACTT1_HUMAN 80.371 0.994709 1.00532 ACTRT1 - Actin-related protein T1 - Homo sapiens (Human) - ACTRT1 gene Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Taurus_UMD|evm.model.AC_000187.1.97 P28370 SMCA1_HUMAN 97.429 0.976723 1.01898 SMARCA1 - Probable global transcription activator SNF2L1 - Homo sapiens (Human) - SMARCA1 gene Energy-transducing component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells. Taurus_UMD|evm.model.AC_000187.1.98 Q01968 OCRL_HUMAN 94.570 0.99774 0.982242 OCRL - Inositol polyphosphate 5-phosphatase OCRL - Homo sapiens (Human) - OCRL gene Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2 (PubMed:7761412, PubMed:15474001, PubMed:9430698, PubMed:10764818). Able also to hydrolyzes the 4-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate (PubMed:7761412, PubMed:25869668). Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes (PubMed:21971085). Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling (PubMed:22072788). Taurus_UMD|evm.model.AC_000187.1.99 Q9TUI9 APEL_BOVIN 100.000 0.974359 1.01299 APLN - Apelin precursor - Bos taurus (Bovine) - APLN gene Endogenous ligand for the apelin receptor (APLNR) (PubMed:9792798). Drives internalization of APLNR (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity). Taurus_UMD|evm.model.AC_000187.1.100 Q95333 XPP2_PIG 88.559 0.997033 1.00149 XPNPEP2 - Xaa-Pro aminopeptidase 2 precursor - Sus scrofa (Pig) - XPNPEP2 gene Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin. Taurus_UMD|evm.model.AC_000187.1.101 E9PRG8 CK098_HUMAN 83.740 0.983871 1.00813 C11orf98 - Uncharacterized protein C11orf98 - Homo sapiens (Human) - C11orf98 gene Taurus_UMD|evm.model.AC_000187.1.102 A0JN71 SASH3_BOVIN 100.000 0.994751 1.00263 SASH3 - SAM and SH3 domain-containing protein 3 - Bos taurus (Bovine) - SASH3 gene May function as a signaling adapter protein in lymphocytes. Taurus_UMD|evm.model.AC_000187.1.103 Q58DA8 ZDHC9_BOVIN 97.844 0.994624 1.02479 ZDHHC9 - Palmitoyltransferase ZDHHC9 - Bos taurus (Bovine) - ZDHHC9 gene Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling. Taurus_UMD|evm.model.AC_000187.1.104 Q8BXX9 CC169_MOUSE 69.458 0.990148 0.948598 Ccdc169 - Coiled-coil domain-containing protein 169 - Mus musculus (Mouse) - Ccdc169 gene Taurus_UMD|evm.model.AC_000187.1.105 Q3T0Q8 UT14A_BOVIN 100.000 0.997406 1.0013 UTP14A - U3 small nucleolar RNA-associated protein 14 homolog A - Bos taurus (Bovine) - UTP14A gene May be required for ribosome biogenesis. Taurus_UMD|evm.model.AC_000187.1.106 A2AQH4 BCORL_MOUSE 87.799 0.998881 1.00337 Bcorl1 - BCL-6 corepressor-like protein 1 - Mus musculus (Mouse) - Bcorl1 gene Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor (By similarity). Taurus_UMD|evm.model.AC_000187.1.107 Q99607 ELF4_HUMAN 87.934 0.996983 1 ELF4 - ETS-related transcription factor Elf-4 - Homo sapiens (Human) - ELF4 gene Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Taurus_UMD|evm.model.AC_000187.1.108 O95831 AIFM1_HUMAN 94.127 0.996743 1.00163 AIFM1 - Apoptosis-inducing factor 1, mitochondrial precursor - Homo sapiens (Human) - AIFM1 gene Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:20362274, PubMed:23217327, PubMed:17094969). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (By similarity). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). Taurus_UMD|evm.model.AC_000187.1.109 Q14088 RB33A_HUMAN 99.156 0.991597 1.00422 RAB33A - Ras-related protein Rab-33A - Homo sapiens (Human) - RAB33A gene endosome, Golgi apparatus, Golgi membrane, GTPase activity, antigen processing and presentation Taurus_UMD|evm.model.AC_000187.1.110 Q8ND82 Z280C_HUMAN 64.639 0.94993 0.975577 ZNF280C - Zinc finger protein 280C - Homo sapiens (Human) - ZNF280C gene May function as a transcription factor. Taurus_UMD|evm.model.AC_000187.1.112 O95258 UCP5_HUMAN 98.000 0.866667 1.06154 SLC25A14 - Brain mitochondrial carrier protein 1 - Homo sapiens (Human) - SLC25A14 gene Participates in the mitochondrial proton leak measured in brain mitochondria. Taurus_UMD|evm.model.AC_000187.1.113 Q7TQN8 GP119_RAT 79.125 0.880952 0.717949 Gpr119 - Glucose-dependent insulinotropic receptor - Rattus norvegicus (Rat) - Gpr119 gene Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway. Taurus_UMD|evm.model.AC_000187.1.114 Q9Y388 RBMX2_HUMAN 78.201 0.802228 1.11491 RBMX2 - RNA-binding motif protein, X-linked 2 - Homo sapiens (Human) - RBMX2 gene Involved in pre-mRNA splicing as component of the activated spliceosome. Taurus_UMD|evm.model.AC_000187.1.115 Q5CZC0 FSIP2_HUMAN 53.895 0.999066 0.930071 FSIP2 - Fibrous sheath-interacting protein 2 - Homo sapiens (Human) - FSIP2 gene Plays a role in spermatogenesis. Taurus_UMD|evm.model.AC_000187.1.116 A2ARZ3 FSIP2_MOUSE 45.012 0.859857 0.0601858 Fsip2 - Fibrous sheath-interacting protein 2 - Mus musculus (Mouse) - Fsip2 gene Plays a role in spermatogenesis. Taurus_UMD|evm.model.AC_000187.1.117 Q16206 ENOX2_HUMAN 95.610 0.894737 0.37377 ENOX2 - Ecto-NOX disulfide-thiol exchanger 2 - Homo sapiens (Human) - ENOX2 gene May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. Taurus_UMD|evm.model.AC_000187.1.118 Q16206 ENOX2_HUMAN 100.000 0.736695 0.585246 ENOX2 - Ecto-NOX disulfide-thiol exchanger 2 - Homo sapiens (Human) - ENOX2 gene May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. Taurus_UMD|evm.model.AC_000187.1.119 A7MB27 RHG36_BOVIN 100.000 0.424889 2.12264 ARHGAP36 - Rho GTPase-activating protein 36 precursor - Bos taurus (Bovine) - ARHGAP36 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000187.1.120 O76002 OR2J2_HUMAN 41.243 0.665179 0.717949 OR2J2 - Olfactory receptor 2J2 - Homo sapiens (Human) - OR2J2 gene Odorant receptor. Taurus_UMD|evm.model.AC_000187.1.121 Q8N6C5 IGSF1_HUMAN 89.522 0.886792 1.11078 IGSF1 - Immunoglobulin superfamily member 1 precursor - Homo sapiens (Human) - IGSF1 gene Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription. Taurus_UMD|evm.model.AC_000187.1.122 P0C5Z0 H2AB2_HUMAN 68.817 0.538012 1.48696 H2AB2 - Histone H2A-Bbd type 2/3 - Homo sapiens (Human) - H2AB2 gene Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis. Taurus_UMD|evm.model.AC_000187.1.123 Q9H207 O10A5_HUMAN 53.103 0.922581 0.488959 OR10A5 - Olfactory receptor 10A5 - Homo sapiens (Human) - OR10A5 gene Odorant receptor (Potential). May be involved in taste perception. Taurus_UMD|evm.model.AC_000187.1.124 Q8NG98 OR7D4_HUMAN 44.755 0.833333 0.480769 OR7D4 - Olfactory receptor 7D4 - Homo sapiens (Human) - OR7D4 gene Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone. Taurus_UMD|evm.model.AC_000187.1.126 Q8NG92 O13H1_HUMAN 43.333 0.951111 0.730519 OR13H1 - Olfactory receptor 13H1 - Homo sapiens (Human) - OR13H1 gene Odorant receptor. Taurus_UMD|evm.model.AC_000187.1.130 Q9P289 STK26_HUMAN 99.038 0.995204 1.0024 STK26 - Serine/threonine-protein kinase 26 - Homo sapiens (Human) - STK26 gene Mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Taurus_UMD|evm.model.AC_000187.1.131 Q6ZUT3 FRMD7_HUMAN 87.903 0.940729 0.921569 FRMD7 - FERM domain-containing protein 7 - Homo sapiens (Human) - FRMD7 gene Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability. Taurus_UMD|evm.model.AC_000187.1.132 Q8BU31 RAP2C_MOUSE 100.000 0.98913 1.00546 Rap2c - Ras-related protein Rap-2c precursor - Mus musculus (Mouse) - Rap2c gene Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription. Taurus_UMD|evm.model.AC_000187.1.133 Q9NRG0 CHRC1_HUMAN 78.261 0.483871 0.709924 CHRAC1 - Chromatin accessibility complex protein 1 - Homo sapiens (Human) - CHRAC1 gene Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Taurus_UMD|evm.model.AC_000187.1.134 Q9NUK0 MBNL3_HUMAN 82.173 0.994444 1.01695 MBNL3 - Muscleblind-like protein 3 - Homo sapiens (Human) - MBNL3 gene Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. Taurus_UMD|evm.model.AC_000187.1.135 Q96MM7 H6ST2_HUMAN 89.298 0.919753 0.535537 HS6ST2 - Heparan-sulfate 6-O-sulfotransferase 2 - Homo sapiens (Human) - HS6ST2 gene 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Taurus_UMD|evm.model.AC_000187.1.140 Q80UW0 H6ST2_MOUSE 87.931 0.798595 0.697712 Hs6st2 - Heparan-sulfate 6-O-sulfotransferase 2 - Mus musculus (Mouse) - Hs6st2 gene 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Taurus_UMD|evm.model.AC_000187.1.141 Q9BXU7 UBP26_HUMAN 46.711 0.978818 0.982475 USP26 - Ubiquitin carboxyl-terminal hydrolase 26 - Homo sapiens (Human) - USP26 gene Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway. Taurus_UMD|evm.model.AC_000187.1.142 Q5R6X7 CBX3_PONAB 52.101 0.939024 0.448087 CBX3 - Chromobox protein homolog 3 - Pongo abelii (Sumatran orangutan) - CBX3 gene Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs). Taurus_UMD|evm.model.AC_000187.1.144 O75487 GPC4_HUMAN 93.525 0.996409 1.0018 GPC4 - Glypican-4 precursor - Homo sapiens (Human) - GPC4 gene Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity). Taurus_UMD|evm.model.AC_000187.1.145 A5A6P7 GPC3_PANTR 95.522 0.975 0.827586 GPC3 - Glypican-3 precursor - Pan troglodytes (Chimpanzee) - GPC3 gene Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (By similarity). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity). Taurus_UMD|evm.model.AC_000187.1.147 O46415 FRIL_BOVIN 88.000 0.98773 0.931429 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000187.1.149 Q2T9U9 CC160_BOVIN 100.000 0.993827 1.0031 CCDC160 - Coiled-coil domain-containing protein 160 - Bos taurus (Bovine) - CCDC160 gene Taurus_UMD|evm.model.AC_000187.1.150 Q08DR0 PHF6_BOVIN 83.186 0.994065 0.923288 PHF6 - PHD finger protein 6 - Bos taurus (Bovine) - PHF6 gene Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. Taurus_UMD|evm.model.AC_000187.1.151 Q3SZ18 HPRT_BOVIN 100.000 0.990868 1.00459 HPRT1 - Hypoxanthine-guanine phosphoribosyltransferase - Bos taurus (Bovine) - HPRT1 gene Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). Taurus_UMD|evm.model.AC_000187.1.152 Q9HBJ0 PLAC1_HUMAN 70.391 0.988889 0.849057 PLAC1 - Placenta-specific protein 1 precursor - Homo sapiens (Human) - PLAC1 gene May play a role in placental development. Taurus_UMD|evm.model.AC_000187.1.153 Q7Z309 PBIR2_HUMAN 79.688 0.99177 0.983806 PABIR2 - PABIR family member 2 - Homo sapiens (Human) - PABIR2 gene Taurus_UMD|evm.model.AC_000187.1.155 Q7Z309 PBIR2_HUMAN 55.385 0.447552 0.578947 PABIR2 - PABIR family member 2 - Homo sapiens (Human) - PABIR2 gene Taurus_UMD|evm.model.AC_000187.1.156 Q2T9W7 MSPD1_BOVIN 100.000 0.990654 1.00469 MOSPD1 - Motile sperm domain-containing protein 1 - Bos taurus (Bovine) - MOSPD1 gene Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. Taurus_UMD|evm.model.AC_000187.1.157 Q1JQ94 RTL8_BOVIN 100.000 0.982456 1.00885 RTL8A - Retrotransposon Gag-like protein 8 - Bos taurus (Bovine) - RTL8A gene nucleolus Taurus_UMD|evm.model.AC_000187.1.160 Q1JQ94 RTL8_BOVIN 100.000 0.982456 1.00885 RTL8A - Retrotransposon Gag-like protein 8 - Bos taurus (Bovine) - RTL8A gene nucleolus Taurus_UMD|evm.model.AC_000187.1.161 Q1JQ94 RTL8_BOVIN 73.529 0.423611 1.27434 RTL8A - Retrotransposon Gag-like protein 8 - Bos taurus (Bovine) - RTL8A gene nucleolus Taurus_UMD|evm.model.AC_000187.1.163 Q1JQ94 RTL8_BOVIN 100.000 0.982456 1.00885 RTL8A - Retrotransposon Gag-like protein 8 - Bos taurus (Bovine) - RTL8A gene nucleolus Taurus_UMD|evm.model.AC_000187.1.164 Q9BXT6 M10L1_HUMAN 57.430 0.987603 0.199835 MOV10L1 - RNA helicase Mov10l1 - Homo sapiens (Human) - MOV10L1 gene ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. Taurus_UMD|evm.model.AC_000187.1.165 P0DMW5 SIL2B_HUMAN 94.828 0.721519 1.01282 SMIM10L2B - Small integral membrane protein 10-like protein 2B - Homo sapiens (Human) - SMIM10L2B gene Taurus_UMD|evm.model.AC_000187.1.166 P51815 ZN75D_HUMAN 60.843 0.859375 0.752941 ZNF75D - Zinc finger protein 75D - Homo sapiens (Human) - ZNF75D gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.167 Q1LZ87 ZN397_BOVIN 64.634 0.503106 0.301498 ZNF397 - Zinc finger protein 397 - Bos taurus (Bovine) - ZNF397 gene DNA-dependent transcriptional repressor. Taurus_UMD|evm.model.AC_000187.1.168 P0DMW5 SIL2B_HUMAN 75.472 0.852459 0.782051 SMIM10L2B - Small integral membrane protein 10-like protein 2B - Homo sapiens (Human) - SMIM10L2B gene Taurus_UMD|evm.model.AC_000187.1.169 P51815 ZN75D_HUMAN 62.349 0.914127 0.707843 ZNF75D - Zinc finger protein 75D - Homo sapiens (Human) - ZNF75D gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.170 P51815 ZN75D_HUMAN 61.000 0.370787 0.523529 ZNF75D - Zinc finger protein 75D - Homo sapiens (Human) - ZNF75D gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.174 Q5RBN9 TAD2B_PONAB 87.441 0.995272 1.00714 TADA2B - Transcriptional adapter 2-beta - Pongo abelii (Sumatran orangutan) - TADA2B gene Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. Taurus_UMD|evm.model.AC_000187.1.175 Q5JSJ4 INT6L_HUMAN 84.933 0.997655 0.990708 INTS6L - Integrator complex subunit 6-like - Homo sapiens (Human) - INTS6L gene integrator complex, snRNA 3'-end processing Taurus_UMD|evm.model.AC_000187.1.176 Q9NXZ1 SAGE1_HUMAN 62.842 0.62543 0.321903 SAGE1 - Sarcoma antigen 1 - Homo sapiens (Human) - SAGE1 gene integrator complex, nuclear body, nucleoplasm, snRNA 3'-end processing Taurus_UMD|evm.model.AC_000187.1.177 Q8N4V1 EMC5_HUMAN 99.237 0.984848 1.00763 MMGT1 - ER membrane protein complex subunit 5 - Homo sapiens (Human) - MMGT1 gene Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (By similarity). May be involved in Mg(2+) transport (By similarity). Taurus_UMD|evm.model.AC_000187.1.178 Q92581 SL9A6_HUMAN 90.833 0.997226 1.07773 SLC9A6 - Sodium/hydrogen exchanger 6 - Homo sapiens (Human) - SLC9A6 gene Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis. Taurus_UMD|evm.model.AC_000187.1.179 Q9WUH4 FHL1_RAT 93.571 0.939394 1.06071 Fhl1 - Four and a half LIM domains protein 1 - Rattus norvegicus (Rat) - Fhl1 gene May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems (By similarity). Taurus_UMD|evm.model.AC_000187.1.180 Q96T17 MA7D2_HUMAN 63.462 0.047486 1.46721 MAP7D2 - MAP7 domain-containing protein 2 - Homo sapiens (Human) - MAP7D2 gene microtubule cytoskeleton, microtubule cytoskeleton organization Taurus_UMD|evm.model.AC_000187.1.181 Q8IZF6 AGRG4_HUMAN 68.790 0.975 0.0519481 ADGRG4 - Adhesion G-protein coupled receptor G4 precursor - Homo sapiens (Human) - ADGRG4 gene Orphan receptor. Taurus_UMD|evm.model.AC_000187.1.183 O97967 BRS3_SHEEP 96.992 0.995 1.00251 BRS3 - Bombesin receptor subtype-3 - Ovis aries (Sheep) - BRS3 gene Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Taurus_UMD|evm.model.AC_000187.1.184 O43719 HTSF1_HUMAN 75.959 0.987261 1.03974 HTATSF1 - HIV Tat-specific factor 1 - Homo sapiens (Human) - HTATSF1 gene Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. Taurus_UMD|evm.model.AC_000187.1.185 Q8N8G2 VGLL2_HUMAN 80.000 0.0514821 2.02208 VGLL2 - Transcription cofactor vestigial-like protein 2 - Homo sapiens (Human) - VGLL2 gene May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles. Taurus_UMD|evm.model.AC_000187.1.186 P51749 CD40L_BOVIN 96.861 0.986667 0.862069 CD40LG - CD40 ligand - Bos taurus (Bovine) - CD40LG gene Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Taurus_UMD|evm.model.AC_000187.1.187 Q15052 ARHG6_HUMAN 94.588 0.967541 1.03222 ARHGEF6 - Rho guanine nucleotide exchange factor 6 - Homo sapiens (Human) - ARHGEF6 gene Acts as a RAC1 guanine nucleotide exchange factor (GEF). Taurus_UMD|evm.model.AC_000187.1.188 A8D8X1 RL10_SHEEP 72.857 0.560976 0.574766 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000187.1.189 A5A6M3 RBMX_PANTR 99.732 0.875294 1.08696 RBMX - RNA-binding motif protein, X chromosome - Pan troglodytes (Chimpanzee) - RBMX gene RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment (By similarity). Taurus_UMD|evm.model.AC_000187.1.190 Q5R8Y6 TM9S2_PONAB 69.352 0.93994 1.00452 TM9SF2 - Transmembrane 9 superfamily member 2 precursor - Pongo abelii (Sumatran orangutan) - TM9SF2 gene In the intracellular compartments, may function as a channel or small molecule transporter. Taurus_UMD|evm.model.AC_000187.1.191 Q96P66 GP101_HUMAN 85.156 0.996032 0.992126 GPR101 - Probable G-protein coupled receptor 101 - Homo sapiens (Human) - GPR101 gene Orphan receptor. Taurus_UMD|evm.model.AC_000187.1.192 Q920A7 AFG31_MOUSE 71.429 0.574586 0.229404 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Taurus_UMD|evm.model.AC_000187.1.193 O60481 ZIC3_HUMAN 96.574 0.633015 1.56959 ZIC3 - Zinc finger protein ZIC 3 - Homo sapiens (Human) - ZIC3 gene Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. Taurus_UMD|evm.model.AC_000187.1.195 Q63HM2 PCX4_HUMAN 90.217 0.983871 0.158703 PCNX4 - Pecanex-like protein 4 - Homo sapiens (Human) - PCNX4 gene Taurus_UMD|evm.model.AC_000187.1.197 A6NCF6 MA13P_HUMAN 61.420 0.975535 0.958944 MAGEA13P - Putative MAGE domain-containing protein MAGEA13P - Homo sapiens (Human) - MAGEA13P gene Taurus_UMD|evm.model.AC_000187.1.198 Q9ERW3 FGF13_RAT 100.000 0.692015 1.07347 Fgf13 - Fibroblast growth factor 13 - Rattus norvegicus (Rat) - Fgf13 gene Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (By similarity). May also play a role in MAPK signaling (By similarity). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity). Taurus_UMD|evm.model.AC_000187.1.201 Q95LF0 I13R2_CANLF 79.202 0.811628 1.11399 IL13RA2 - Interleukin-13 receptor subunit alpha-2 precursor - Canis lupus familiaris (Dog) - IL13RA2 gene Binds as a monomer with high affinity to interleukin-13 (IL13). Taurus_UMD|evm.model.AC_000187.1.202 Q17QI2 SSU72_BOVIN 67.010 0.787129 1.04124 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Bos taurus (Bovine) - SSU72 gene Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK (By similarity). Taurus_UMD|evm.model.AC_000187.1.204 Q5ZJQ7 SSU72_CHICK 77.863 0.984496 0.664948 SSU72 - RNA polymerase II subunit A C-terminal domain phosphatase SSU72 - Gallus gallus (Chicken) - SSU72 gene May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination. Taurus_UMD|evm.model.AC_000187.1.205 P00741 FA9_BOVIN 100.000 0.99568 1.00216 F9 - Coagulation factor IX precursor - Bos taurus (Bovine) - F9 gene Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. Taurus_UMD|evm.model.AC_000187.1.206 P10911 MCF2_HUMAN 83.333 0.796217 1.2573 MCF2 - Proto-oncogene DBL - Homo sapiens (Human) - MCF2 gene Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42. Taurus_UMD|evm.model.AC_000187.1.207 Q8NB49 AT11C_HUMAN 93.494 0.985062 1.0053 ATP11C - Phospholipid-transporting ATPase IG - Homo sapiens (Human) - ATP11C gene Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:32493773, PubMed:24904167, PubMed:26567335). Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages (PubMed:26944472). Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity). Taurus_UMD|evm.model.AC_000187.1.208 Q920A7 AFG31_MOUSE 81.905 0.863636 0.306717 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Taurus_UMD|evm.model.AC_000187.1.209 P61959 SUMO2_RAT 98.947 0.979167 1.01053 Sumo2 - Small ubiquitin-related modifier 2 precursor - Rattus norvegicus (Rat) - Sumo2 gene Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity). Taurus_UMD|evm.model.AC_000187.1.211 Q2YDJ5 CX066_BOVIN 96.953 0.994475 1.00277 Uncharacterized protein CXorf66 homolog precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000187.1.212 Q14CZ0 CP072_HUMAN 67.556 0.89243 0.912727 C16orf72 - UPF0472 protein C16orf72 - Homo sapiens (Human) - C16orf72 gene Taurus_UMD|evm.model.AC_000187.1.213 Q58D31 DHSO_BOVIN 62.500 0.858182 0.772472 SORD - Sorbitol dehydrogenase - Bos taurus (Bovine) - SORD gene Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with xylitol, D-sorbitol (D-glucitol) and L-iditol as substrates, leading to the C2-oxidized products D-xylulose, D-fructose and L-sorbose, respectively (PubMed:9143345). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). Cannot use NADP(+) as the electron acceptor. Has no activity on ethanol, methanol, glycerol, galactitol and fructose 6-phosphate (PubMed:9143345). Taurus_UMD|evm.model.AC_000187.1.215 P53784 SOX3_MOUSE 95.625 0.987342 0.421333 Sox3 - Transcription factor SOX-3 - Mus musculus (Mouse) - Sox3 gene Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Taurus_UMD|evm.model.AC_000187.1.216 P53784 SOX3_MOUSE 81.928 0.450549 0.485333 Sox3 - Transcription factor SOX-3 - Mus musculus (Mouse) - Sox3 gene Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Taurus_UMD|evm.model.AC_000187.1.220 Q4R4Z6 RS3A_MACFA 89.474 0.745763 0.670455 RPS3A - 40S ribosomal protein S3a - Macaca fascicularis (Crab-eating macaque) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Taurus_UMD|evm.model.AC_000187.1.222 Q17QF6 LDOC1_BOVIN 99.315 0.986395 1.00685 LDOC1 - Protein LDOC1 - Bos taurus (Bovine) - LDOC1 gene May have an important role in the development and/or progression of some cancers. Taurus_UMD|evm.model.AC_000187.1.225 P43362 MAGA9_HUMAN 57.143 0.927778 0.571429 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.226 P43363 MAGAA_HUMAN 47.783 0.766284 0.707317 MAGEA10 - Melanoma-associated antigen 10 - Homo sapiens (Human) - MAGEA10 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.227 Q2YDJ5 CX066_BOVIN 75.676 0.99095 0.612188 Uncharacterized protein CXorf66 homolog precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000187.1.230 Q8IW52 SLIK4_HUMAN 97.255 0.839357 1.18996 SLITRK4 - SLIT and NTRK-like protein 4 precursor - Homo sapiens (Human) - SLITRK4 gene It is involved in synaptogenesis and promotes synapse differentiation (PubMed:27812321). Suppresses neurite outgrowth (By similarity). Taurus_UMD|evm.model.AC_000187.1.231 P62936 PPIA_PIG 75.490 0.971154 0.634146 PPIA - Peptidyl-prolyl cis-trans isomerase A - Sus scrofa (Pig) - PPIA gene Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity). Taurus_UMD|evm.model.AC_000187.1.232 A6NCF6 MA13P_HUMAN 57.317 0.958944 1 MAGEA13P - Putative MAGE domain-containing protein MAGEA13P - Homo sapiens (Human) - MAGEA13P gene Taurus_UMD|evm.model.AC_000187.1.234 Q9H156 SLIK2_HUMAN 97.041 0.997633 1 SLITRK2 - SLIT and NTRK-like protein 2 precursor - Homo sapiens (Human) - SLITRK2 gene It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Suppresses neurite outgrowth (By similarity). Taurus_UMD|evm.model.AC_000187.1.236 O97965 STP3_SHEEP 80.000 0.981982 1.00909 Spermatid nuclear transition protein 3 - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000187.1.238 O00472 ELL2_HUMAN 43.393 0.948882 0.978125 ELL2 - RNA polymerase II elongation factor ELL2 - Homo sapiens (Human) - ELL2 gene Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. Taurus_UMD|evm.model.AC_000187.1.239 Q5R7F9 MA7D2_PONAB 75.824 0.873239 0.930537 MAP7D2 - MAP7 domain-containing protein 2 - Pongo abelii (Sumatran orangutan) - MAP7D2 gene Taurus_UMD|evm.model.AC_000187.1.240 A2AJT9 BCLA3_HUMAN 72.168 0.997187 1 BCLAF3 - BCLAF1 and THRAP3 family member 3 - Homo sapiens (Human) - BCLAF3 gene mediator complex, DNA binding, transcription coregulator activity, positive regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000187.1.242 Q06787 FMR1_HUMAN 96.203 0.99684 1.00158 FMR1 - Synaptic functional regulator FMR1 - Homo sapiens (Human) - FMR1 gene Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs (PubMed:16631377, PubMed:18653529, PubMed:19166269, PubMed:23235829, PubMed:25464849). Plays a role in the alternative splicing of its own mRNA (PubMed:18653529). Plays a role in mRNA nuclear export (By similarity). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein (MBP) mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (By similarity). Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in response to mGluR activation in a kinesin-dependent manner (By similarity). Plays a role as a repressor of mRNA translation during the transport of dendritic mRNAs to postsynaptic dendritic spines (PubMed:11532944, PubMed:11157796, PubMed:12594214, PubMed:23235829). Component of the CYFIP1-EIF4E-FMR1 complex which blocks cap-dependent mRNA translation initiation (By similarity). Represses mRNA translation by stalling ribosomal translocation during elongation (By similarity). Reports are contradictory with regards to its ability to mediate translation inhibition of MBP mRNA in oligodendrocytes (PubMed:23891804). Also involved in the recruitment of the RNA helicase MOV10 to a subset of mRNAs and hence regulates microRNA (miRNA)-mediated translational repression by AGO2 (PubMed:14703574, PubMed:17057366, PubMed:25464849). Facilitates the assembly of miRNAs on specific target mRNAs (PubMed:17057366). Plays also a role as an activator of mRNA translation of a subset of dendritic mRNAs at synapses (PubMed:19097999, PubMed:19166269). In response to mGluR stimulation, FMR1-target mRNAs are rapidly derepressed, allowing for local translation at synapses (By similarity). Binds to a large subset of dendritic mRNAs that encode a myriad of proteins involved in pre- and postsynaptic functions (PubMed:7692601, PubMed:11719189, PubMed:11157796, PubMed:12594214, PubMed:17417632, PubMed:23235829, PubMed:24448548). Binds to 5'-ACU[GU]-3' and/or 5'-[AU]GGA-3' RNA consensus sequences within mRNA targets, mainly at coding sequence (CDS) and 3'-untranslated region (UTR) and less frequently at 5'-UTR (PubMed:23235829). Binds to intramolecular G-quadruplex structures in the 5'- or 3'-UTRs of mRNA targets (PubMed:11719189, PubMed:18579868, PubMed:25464849, PubMed:25692235). Binds to G-quadruplex structures in the 3'-UTR of its own mRNA (PubMed:7692601, PubMed:11532944, PubMed:12594214, PubMed:15282548, PubMed:18653529). Binds also to RNA ligands harboring a kissing complex (kc) structure; this binding may mediate the association of FMR1 with polyribosomes (PubMed:15805463). Binds mRNAs containing U-rich target sequences (PubMed:12927206). Binds to a triple stem-loop RNA structure, called Sod1 stem loop interacting with FMRP (SoSLIP), in the 5'-UTR region of superoxide dismutase SOD1 mRNA (PubMed:19166269). Binds to the dendritic, small non-coding brain cytoplasmic RNA 1 (BC1); which may increase the association of the CYFIP1-EIF4E-FMR1 complex to FMR1 target mRNAs at synapses (By similarity). Associates with export factor NXF1 mRNA-containing ribonucleoprotein particles (mRNPs) in a NXF2-dependent manner (By similarity). Binds to a subset of miRNAs in the brain (PubMed:14703574, PubMed:17057366). May associate with nascent transcripts in a nuclear protein NXF1-dependent manner (PubMed:18936162). In vitro, binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:7688265, PubMed:7781595, PubMed:12950170, PubMed:15381419, PubMed:8156595). Moreover, plays a role in the modulation of the sodium-activated potassium channel KCNT1 gating activity (PubMed:20512134). Negatively regulates the voltage-dependent calcium channel current density in soma and presynaptic terminals of dorsal root ganglion (DRG) neurons, and hence regulates synaptic vesicle exocytosis (By similarity). Modulates the voltage-dependent calcium channel CACNA1B expression at the plasma membrane by targeting the channels for proteosomal degradation (By similarity). Plays a role in regulation of MAP1B-dependent microtubule dynamics during neuronal development (By similarity). Recently, has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons (PubMed:25561520). Finally, FMR1 may be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AX/H2A.x and BRCA1 phosphorylations (PubMed:24813610). Taurus_UMD|evm.model.AC_000187.1.243 Q8N0W7 FMR1N_HUMAN 38.693 0.62963 0.952941 FMR1NB - Fragile X mental retardation 1 neighbor protein - Homo sapiens (Human) - FMR1NB gene Taurus_UMD|evm.model.AC_000187.1.244 Q7YQM1 AFF2_PONPY 87.842 0.877005 0.294025 AFF2 - AF4/FMR2 family member 2 - Pongo pygmaeus (Bornean orangutan) - AFF2 gene RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure (By similarity). Taurus_UMD|evm.model.AC_000187.1.245 Q7YQM1 AFF2_PONPY 85.903 0.997344 0.591981 AFF2 - AF4/FMR2 family member 2 - Pongo pygmaeus (Bornean orangutan) - AFF2 gene RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure (By similarity). Taurus_UMD|evm.model.AC_000187.1.246 Q3T090 TSR2_BOVIN 78.750 0.887006 0.931579 TSR2 - Pre-rRNA-processing protein TSR2 homolog - Bos taurus (Bovine) - TSR2 gene May be involved in 20S pre-rRNA processing. Taurus_UMD|evm.model.AC_000187.1.248 P22304 IDS_HUMAN 87.218 0.910138 0.789091 IDS - Iduronate 2-sulfatase precursor - Homo sapiens (Human) - IDS gene Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. Taurus_UMD|evm.model.AC_000187.1.249 Q8TE69 EOLA1_HUMAN 63.529 0.497041 1.06962 EOLA1 - Protein EOLA1 - Homo sapiens (Human) - EOLA1 gene May play a role in cell protection during the inflammatory response. In epithelial cells, negatively regulates IL6 production and apoptosis through the regulation of MT2A expession (PubMed:24916366). Taurus_UMD|evm.model.AC_000187.1.250 A0A1B0GTS1 HSFX4_HUMAN 52.239 0.605505 0.327327 HSFX4 - Heat shock transcription factor, X-linked member 4 - Homo sapiens (Human) - HSFX4 gene nucleus, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000187.1.251 A0A1B0GWH4 HSFX3_HUMAN 47.170 0.303263 1.56456 HSFX3 - Heat shock transcription factor, X-linked member 3 - Homo sapiens (Human) - HSFX3 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000187.1.252 P43357 MAGA3_HUMAN 47.847 0.787072 0.83758 MAGEA3 - Melanoma-associated antigen 3 - Homo sapiens (Human) - MAGEA3 gene Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Taurus_UMD|evm.model.AC_000187.1.253 P43362 MAGA9_HUMAN 48.507 0.642105 0.603175 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.254 P43362 MAGA9_HUMAN 46.629 0.356989 1.47619 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.255 Q8CD54 PIEZ2_MOUSE 76.471 0.110738 0.211198 Piezo2 - Piezo-type mechanosensitive ion channel component 2 - Mus musculus (Mouse) - Piezo2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:20813920, PubMed:24717433). Required for Merkel-cell mechanotransduction (PubMed:24717433). Plays a major role in light-touch mechanosensation (PubMed:25471886). Taurus_UMD|evm.model.AC_000187.1.256 Q9H5I5 PIEZ2_HUMAN 74.667 0.814208 0.0664971 PIEZO2 - Piezo-type mechanosensitive ion channel component 2 - Homo sapiens (Human) - PIEZO2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. Taurus_UMD|evm.model.AC_000187.1.257 A7MB35 ODPA_BOVIN 80.357 0.987097 0.397436 PDHA1 - Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor - Bos taurus (Bovine) - PDHA1 gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Taurus_UMD|evm.model.AC_000187.1.258 Q8CD54 PIEZ2_MOUSE 85.047 0.193784 0.193834 Piezo2 - Piezo-type mechanosensitive ion channel component 2 - Mus musculus (Mouse) - Piezo2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:20813920, PubMed:24717433). Required for Merkel-cell mechanotransduction (PubMed:24717433). Plays a major role in light-touch mechanosensation (PubMed:25471886). Taurus_UMD|evm.model.AC_000187.1.259 P43357 MAGA3_HUMAN 48.293 0.771863 0.83758 MAGEA3 - Melanoma-associated antigen 3 - Homo sapiens (Human) - MAGEA3 gene Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Taurus_UMD|evm.model.AC_000187.1.260 P43362 MAGA9_HUMAN 44.444 0.745583 0.898413 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.261 P43364 MAGAB_HUMAN 61.194 0.24 0.641026 MAGEA11 - Melanoma-associated antigen 11 - Homo sapiens (Human) - MAGEA11 gene Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.262 P43357 MAGA3_HUMAN 48.325 0.71134 0.926752 MAGEA3 - Melanoma-associated antigen 3 - Homo sapiens (Human) - MAGEA3 gene Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Taurus_UMD|evm.model.AC_000187.1.263 Q9H5I5 PIEZ2_HUMAN 88.889 0.978022 0.0330669 PIEZO2 - Piezo-type mechanosensitive ion channel component 2 - Homo sapiens (Human) - PIEZO2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. Taurus_UMD|evm.model.AC_000187.1.264 P43362 MAGA9_HUMAN 54.124 0.574405 1.06667 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.265 P43362 MAGA9_HUMAN 51.923 0.714286 0.688889 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.266 P43363 MAGAA_HUMAN 52.830 0.805344 0.710027 MAGEA10 - Melanoma-associated antigen 10 - Homo sapiens (Human) - MAGEA10 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.268 Q96LI6 HSFY1_HUMAN 50.549 0.489011 0.453865 HSFY1 - Heat shock transcription factor, Y-linked - Homo sapiens (Human) - HSFY1 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000187.1.269 Q9H5I5 PIEZ2_HUMAN 70.248 0.809917 0.043968 PIEZO2 - Piezo-type mechanosensitive ion channel component 2 - Homo sapiens (Human) - PIEZO2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. Taurus_UMD|evm.model.AC_000187.1.270 P43363 MAGAA_HUMAN 54.245 0.805344 0.710027 MAGEA10 - Melanoma-associated antigen 10 - Homo sapiens (Human) - MAGEA10 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.271 P43362 MAGA9_HUMAN 52.564 0.714286 0.688889 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.272 P43362 MAGA9_HUMAN 54.639 0.336842 0.904762 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.274 Q8TE69 EOLA1_HUMAN 66.667 0.394366 0.898734 EOLA1 - Protein EOLA1 - Homo sapiens (Human) - EOLA1 gene May play a role in cell protection during the inflammatory response. In epithelial cells, negatively regulates IL6 production and apoptosis through the regulation of MT2A expession (PubMed:24916366). Taurus_UMD|evm.model.AC_000187.1.275 P43362 MAGA9_HUMAN 53.378 0.910828 0.498413 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.276 P43363 MAGAA_HUMAN 49.451 0.989071 0.495935 MAGEA10 - Melanoma-associated antigen 10 - Homo sapiens (Human) - MAGEA10 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.277 A2AF53 T185A_MOUSE 99.143 0.840964 1.18571 Tmem185a - Transmembrane protein 185A - Mus musculus (Mouse) - Tmem185a gene dendrite Taurus_UMD|evm.model.AC_000187.1.278 Q96LI6 HSFY1_HUMAN 51.220 0.290909 0.685786 HSFY1 - Heat shock transcription factor, Y-linked - Homo sapiens (Human) - HSFY1 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000187.1.279 P43362 MAGA9_HUMAN 51.869 0.80303 0.838095 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.280 P43362 MAGA9_HUMAN 53.846 0.753906 0.812698 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.283 Q13495 MAMD1_HUMAN 65.206 0.997085 0.886305 MAMLD1 - Mastermind-like domain-containing protein 1 - Homo sapiens (Human) - MAMLD1 gene Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. Taurus_UMD|evm.model.AC_000187.1.285 A6QLT4 MTM1_BOVIN 100.000 0.967846 1.03151 MTM1 - Myotubularin - Bos taurus (Bovine) - MTM1 gene Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels. Taurus_UMD|evm.model.AC_000187.1.286 Q13613 MTMR1_HUMAN 91.781 0.956204 1.03008 MTMR1 - Myotubularin-related protein 1 - Homo sapiens (Human) - MTMR1 gene Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:11733541, PubMed:27018598). Activity with phosphatidylinositol (3,5)-bisphosphate is controversial; it has been shown by PubMed:27018598, while PubMed:11733541 find no activity with this substrate. Taurus_UMD|evm.model.AC_000187.1.287 A1A4K1 C99L2_BOVIN 100.000 0.624113 0.64977 CD99L2 - CD99 antigen-like protein 2 precursor - Bos taurus (Bovine) - CD99L2 gene Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity). Taurus_UMD|evm.model.AC_000187.1.289 Q32L31 HMGB3_BOVIN 100.000 0.723636 1.375 HMGB3 - High mobility group protein B3 - Bos taurus (Bovine) - HMGB3 gene Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). Taurus_UMD|evm.model.AC_000187.1.290 Q28558 MTR1L_SHEEP 94.783 0.996528 1.00174 GPR50 - Melatonin-related receptor - Ovis aries (Sheep) - GPR50 gene Does not bind melatonin. Taurus_UMD|evm.model.AC_000187.1.293 A2VDK9 VMA21_BOVIN 97.701 0.710744 1.19802 VMA21 - Vacuolar ATPase assembly integral membrane protein VMA21 - Bos taurus (Bovine) - VMA21 gene Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. Taurus_UMD|evm.model.AC_000187.1.294 Q8IV76 PASD1_HUMAN 39.815 0.158209 0.866753 PASD1 - Circadian clock protein PASD1 - Homo sapiens (Human) - PASD1 gene Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801). Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801). Taurus_UMD|evm.model.AC_000187.1.295 Q16778 H2B2E_HUMAN 90.476 0.984252 1.00794 H2BC21 - Histone H2B type 2-E - Homo sapiens (Human) - H2BC21 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000187.1.296 Q9BZD7 TMG3_HUMAN 94.372 0.991379 1.00433 PRRG3 - Transmembrane gamma-carboxyglutamic acid protein 3 precursor - Homo sapiens (Human) - PRRG3 gene integral component of membrane Taurus_UMD|evm.model.AC_000187.1.297 Q95LA0 FATE1_BOVIN 99.444 0.788546 1.26111 FATE1 - Fetal and adult testis-expressed transcript protein homolog - Bos taurus (Bovine) - FATE1 gene Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling. Taurus_UMD|evm.model.AC_000187.1.298 Q03041 CNGA2_BOVIN 99.698 0.996988 1.00151 CNGA2 - Cyclic nucleotide-gated olfactory channel - Bos taurus (Bovine) - CNGA2 gene Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons. Taurus_UMD|evm.model.AC_000187.1.300 P43363 MAGAA_HUMAN 61.582 0.778761 0.612466 MAGEA10 - Melanoma-associated antigen 10 - Homo sapiens (Human) - MAGEA10 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.301 P78334 GBRE_HUMAN 70.312 0.99596 0.978261 GABRE - Gamma-aminobutyric acid receptor subunit epsilon precursor - Homo sapiens (Human) - GABRE gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Taurus_UMD|evm.model.AC_000187.1.303 P43355 MAGA1_HUMAN 56.855 0.664865 1.19741 MAGEA1 - Melanoma-associated antigen 1 - Homo sapiens (Human) - MAGEA1 gene May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Taurus_UMD|evm.model.AC_000187.1.304 P10064 GBRA3_BOVIN 99.797 0.947876 1.05285 GABRA3 - Gamma-aminobutyric acid receptor subunit alpha-3 precursor - Bos taurus (Bovine) - GABRA3 gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Taurus_UMD|evm.model.AC_000187.1.305 Q9UN88 GBRT_HUMAN 62.482 0.997063 1.07753 GABRQ - Gamma-aminobutyric acid receptor subunit theta precursor - Homo sapiens (Human) - GABRQ gene GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Taurus_UMD|evm.model.AC_000187.1.306 P43355 MAGA1_HUMAN 53.232 0.772189 1.09385 MAGEA1 - Melanoma-associated antigen 1 - Homo sapiens (Human) - MAGEA1 gene May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Taurus_UMD|evm.model.AC_000187.1.307 Q2TBN3 CETN2_BOVIN 100.000 0.988439 1.00581 CETN2 - Centrin-2 - Bos taurus (Bovine) - CETN2 gene Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity). Taurus_UMD|evm.model.AC_000187.1.308 Q3ZBE9 NSDHL_BOVIN 100.000 0.994398 1.00281 NSDHL - Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating - Bos taurus (Bovine) - NSDHL gene Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis. Plays also a role in the regulation of the endocytic trafficking of EGFR. Taurus_UMD|evm.model.AC_000187.1.309 O15231 ZN185_HUMAN 57.308 0.952888 0.955007 ZNF185 - Zinc finger protein 185 - Homo sapiens (Human) - ZNF185 gene May be involved in the regulation of cellular proliferation and/or differentiation. Taurus_UMD|evm.model.AC_000187.1.310 Q8TE69 EOLA1_HUMAN 75.316 0.94012 1.05696 EOLA1 - Protein EOLA1 - Homo sapiens (Human) - EOLA1 gene May play a role in cell protection during the inflammatory response. In epithelial cells, negatively regulates IL6 production and apoptosis through the regulation of MT2A expession (PubMed:24916366). Taurus_UMD|evm.model.AC_000187.1.311 A0A1B0GWH4 HSFX3_HUMAN 56.364 0.608939 0.537538 HSFX3 - Heat shock transcription factor, X-linked member 3 - Homo sapiens (Human) - HSFX3 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000187.1.315 Q7L2H7 EIF3M_HUMAN 100.000 0.994667 1.00267 EIF3M - Eukaryotic translation initiation factor 3 subunit M - Homo sapiens (Human) - EIF3M gene Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Taurus_UMD|evm.model.AC_000187.1.317 Q9H7L2 KI3X1_HUMAN 54.965 0.652381 1.19318 KIR3DX1 - Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 precursor - Homo sapiens (Human) - KIR3DX1 gene Taurus_UMD|evm.model.AC_000187.1.318 O97965 STP3_SHEEP 79.348 0.947917 0.872727 Spermatid nuclear transition protein 3 - Ovis aries (Sheep) Taurus_UMD|evm.model.AC_000187.1.321 Q8TE69 EOLA1_HUMAN 62.162 0.133212 3.46835 EOLA1 - Protein EOLA1 - Homo sapiens (Human) - EOLA1 gene May play a role in cell protection during the inflammatory response. In epithelial cells, negatively regulates IL6 production and apoptosis through the regulation of MT2A expession (PubMed:24916366). Taurus_UMD|evm.model.AC_000187.1.322 A0A1B0GWH4 HSFX3_HUMAN 48.378 0.936111 1.08108 HSFX3 - Heat shock transcription factor, X-linked member 3 - Homo sapiens (Human) - HSFX3 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000187.1.323 P43355 MAGA1_HUMAN 57.692 0.205747 2.81553 MAGEA1 - Melanoma-associated antigen 1 - Homo sapiens (Human) - MAGEA1 gene May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Taurus_UMD|evm.model.AC_000187.1.324 Q52M98 1433T_XENLA 89.796 0.489796 0.4 ywhaq - 14-3-3 protein theta - Xenopus laevis (African clawed frog) - ywhaq gene Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Taurus_UMD|evm.model.AC_000187.1.326 Q2NKS9 BBLN_BOVIN 52.459 0.582524 1.24096 BBLN - Bublin coiled-coil protein - Bos taurus (Bovine) - BBLN gene Taurus_UMD|evm.model.AC_000187.1.327 P58686 BBLN_MOUSE 46.429 0.805825 1.24096 Bbln - Bublin coiled-coil protein - Mus musculus (Mouse) - Bbln gene Taurus_UMD|evm.model.AC_000187.1.328 Q5R9Q6 RAMAC_PONAB 93.443 0.48 1.05932 RAMAC - RNA guanine-N7 methyltransferase activating subunit - Pongo abelii (Sumatran orangutan) - RAMAC gene Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT. Regulates RNMT expression by a post-transcriptional stabilizing mechanism. Binds RNA. Taurus_UMD|evm.model.AC_000187.1.329 Q9H5I5 PIEZ2_HUMAN 62.667 0.640187 0.0777616 PIEZO2 - Piezo-type mechanosensitive ion channel component 2 - Homo sapiens (Human) - PIEZO2 gene Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. Taurus_UMD|evm.model.AC_000187.1.330 P51809 VAMP7_HUMAN 100.000 0.91129 0.563636 VAMP7 - Vesicle-associated membrane protein 7 - Homo sapiens (Human) - VAMP7 gene Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. Taurus_UMD|evm.model.AC_000187.1.331 O43610 SPY3_HUMAN 96.528 0.99308 1.00347 SPRY3 - Protein sprouty homolog 3 - Homo sapiens (Human) - SPRY3 gene Inhibits neurite branching, arbor length and neurite complexity (By similarity). Inhibits EGF-mediated p42/44 ERK signaling (By similarity). Negatively regulates the MAPK cascade, resulting in a reduction of extracellular matrix protein accumulation (PubMed:30878395). May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis (PubMed:9458049). Taurus_UMD|evm.model.AC_000187.1.332 Q10126 YSM6_CAEEL 26.210 0.732484 1.12545 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000187.1.334 Q0VC74 TMLH_BOVIN 100.000 0.99308 0.686461 TMLHE - Trimethyllysine dioxygenase, mitochondrial precursor - Bos taurus (Bovine) - TMLHE gene Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML). Taurus_UMD|evm.model.AC_000187.1.335 Q5R5C3 FAM3A_PONAB 76.316 0.421687 0.36087 FAM3A - Protein FAM3A precursor - Pongo abelii (Sumatran orangutan) - FAM3A gene Taurus_UMD|evm.model.AC_000187.1.336 Q0VC74 TMLH_BOVIN 100.000 0.771242 0.36342 TMLHE - Trimethyllysine dioxygenase, mitochondrial precursor - Bos taurus (Bovine) - TMLHE gene Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML). Taurus_UMD|evm.model.AC_000187.1.338 O15247 CLIC2_HUMAN 93.117 0.991935 1.00405 CLIC2 - Chloride intracellular channel protein 2 - Homo sapiens (Human) - CLIC2 gene Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. Taurus_UMD|evm.model.AC_000187.1.339 Q58DW0 RL4_BOVIN 92.705 0.993939 0.781991 RPL4 - 60S ribosomal protein L4 - Bos taurus (Bovine) - RPL4 gene cytosolic large ribosomal subunit, RNA binding, structural constituent of ribosome Taurus_UMD|evm.model.AC_000187.1.340 P23610 HAP40_HUMAN 84.330 0.943243 0.997305 F8A1 - 40-kDa huntingtin-associated protein - Homo sapiens (Human) - F8A1 gene RAB5A effector molecule that is involved in vesicular trafficking of early endosomes (PubMed:16476778). Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility (PubMed:16476778). Taurus_UMD|evm.model.AC_000187.1.341 Q17QU4 RB39B_BOVIN 100.000 0.990654 1.00469 RAB39B - Ras-related protein Rab-39B - Bos taurus (Bovine) - RAB39B gene Small GTPases Rab involved in autophagy. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission (By similarity). Taurus_UMD|evm.model.AC_000187.1.342 Q2HJ33 OLA1_BOVIN 99.747 0.994962 1.00253 OLA1 - Obg-like ATPase 1 - Bos taurus (Bovine) - OLA1 gene Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. Taurus_UMD|evm.model.AC_000187.1.343 Q2TBX2 PFD3_BOVIN 99.492 0.989899 1.00508 VBP1 - Prefoldin subunit 3 - Bos taurus (Bovine) - VBP1 gene Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Taurus_UMD|evm.model.AC_000187.1.344 O55012 PICAL_RAT 67.407 0.845912 0.496875 Picalm - Phosphatidylinositol-binding clathrin assembly protein - Rattus norvegicus (Rat) - Picalm gene Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF). Taurus_UMD|evm.model.AC_000187.1.345 Q5R9L6 BRCC3_PONAB 86.345 0.946565 1.06073 BRCC3 - Lys-63-specific deubiquitinase BRCC36 - Pongo abelii (Sumatran orangutan) - BRCC3 gene Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Taurus_UMD|evm.model.AC_000187.1.346 P56278 MTCP1_HUMAN 94.393 0.981481 1.00935 MTCP1 - Protein p13 MTCP-1 - Homo sapiens (Human) - MTCP1 gene Enhances the phosphorylation and activation of AKT1 and AKT2. Taurus_UMD|evm.model.AC_000187.1.347 Q0VBY0 CMC4_BOVIN 100.000 0.971014 1.01471 CMC4 - Cx9C motif-containing protein 4 - Bos taurus (Bovine) - CMC4 gene mitochondrial intermembrane space Taurus_UMD|evm.model.AC_000187.1.348 Q8MJN0 FUND2_BOVIN 100.000 0.989529 1.00526 FUNDC2 - FUN14 domain-containing protein 2 - Bos taurus (Bovine) - FUNDC2 gene integral component of mitochondrial outer membrane, autophagy of mitochondrion Taurus_UMD|evm.model.AC_000187.1.349 P12263 FA8_PIG 78.057 0.389845 1.08955 F8 - Coagulation factor VIII precursor - Sus scrofa (Pig) - F8 gene Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Taurus_UMD|evm.model.AC_000187.1.350 A6NGZ8 SMIM9_HUMAN 50.820 0.923077 0.656566 SMIM9 - Small integral membrane protein 9 precursor - Homo sapiens (Human) - SMIM9 gene Taurus_UMD|evm.model.AC_000187.1.351 Q17QN6 EM55_BOVIN 100.000 0.995717 1.00215 MPP1 - 55 kDa erythrocyte membrane protein - Bos taurus (Bovine) - MPP1 gene Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). Taurus_UMD|evm.model.AC_000187.1.352 O60832 DKC1_HUMAN 91.440 0.996055 0.986381 DKC1 - H/ACA ribonucleoprotein complex subunit DKC1 - Homo sapiens (Human) - DKC1 gene Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). Taurus_UMD|evm.model.AC_000187.1.353 Q8WWW8 GAB3_HUMAN 78.268 0.996587 1 GAB3 - GRB2-associated-binding protein 3 - Homo sapiens (Human) - GAB3 gene Taurus_UMD|evm.model.AC_000187.1.354 Q9H7L2 KI3X1_HUMAN 53.629 0.297767 2.28977 KIR3DX1 - Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 precursor - Homo sapiens (Human) - KIR3DX1 gene Taurus_UMD|evm.model.AC_000187.1.355 P43631 KI2S2_HUMAN 68.889 0.341085 0.424342 KIR2DS2 - Killer cell immunoglobulin-like receptor 2DS2 precursor - Homo sapiens (Human) - KIR2DS2 gene Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Taurus_UMD|evm.model.AC_000187.1.356 Q9H7L2 KI3X1_HUMAN 53.381 0.312994 2.5142 KIR3DX1 - Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1 precursor - Homo sapiens (Human) - KIR3DX1 gene Taurus_UMD|evm.model.AC_000187.1.358 P43628 KI2L3_HUMAN 64.444 0.0589812 2.18768 KIR2DL3 - Killer cell immunoglobulin-like receptor 2DL3 precursor - Homo sapiens (Human) - KIR2DL3 gene Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis. Taurus_UMD|evm.model.AC_000187.1.359 P43626 KI2L1_HUMAN 47.154 0.542222 0.646552 KIR2DL1 - Killer cell immunoglobulin-like receptor 2DL1 precursor - Homo sapiens (Human) - KIR2DL1 gene Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis. Taurus_UMD|evm.model.AC_000187.1.360 B1H224 PWP3A_RAT 51.724 0.421283 0.982808 Pwwp3a - PWWP domain-containing DNA repair factor 3A - Rattus norvegicus (Rat) - Pwwp3a gene Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage (By similarity). Taurus_UMD|evm.model.AC_000187.1.361 Q9NSD4 ZN275_HUMAN 90.691 0.994695 0.878788 ZNF275 - Zinc finger protein 275 - Homo sapiens (Human) - ZNF275 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.362 A0A0J9YX94 PMA6F_HUMAN 41.818 0.943231 0.396194 PNMA6F - Paraneoplastic antigen Ma6F - Homo sapiens (Human) - PNMA6F gene Taurus_UMD|evm.model.AC_000187.1.364 Q9R1A9 TREX2_MOUSE 83.495 0.953271 0.45339 Trex2 - Three prime repair exonuclease 2 - Mus musculus (Mouse) - Trex2 gene Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair. Taurus_UMD|evm.model.AC_000187.1.365 Q99871 HAUS7_HUMAN 71.910 0.948509 1.00272 HAUS7 - HAUS augmin-like complex subunit 7 - Homo sapiens (Human) - HAUS7 gene Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Taurus_UMD|evm.model.AC_000187.1.366 Q3MHH9 ECM2_BOVIN 52.507 0.739216 0.75 ECM2 - Extracellular matrix protein 2 precursor - Bos taurus (Bovine) - ECM2 gene Promotes matrix assembly and cell adhesiveness. Taurus_UMD|evm.model.AC_000187.1.367 P21809 PGS1_BOVIN 100.000 0.771488 1.29268 BGN - Biglycan precursor - Bos taurus (Bovine) - BGN gene May be involved in collagen fiber assembly. Taurus_UMD|evm.model.AC_000187.1.368 Q64568 AT2B3_RAT 96.900 0.9984 0.993641 Atp2b3 - Plasma membrane calcium-transporting ATPase 3 - Rattus norvegicus (Rat) - Atp2b3 gene ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:25014339, PubMed:9880546). May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established (PubMed:25014339, PubMed:9880546). Taurus_UMD|evm.model.AC_000187.1.369 Q8N1B3 CCNQ_HUMAN 88.362 0.920319 1.0121 CCNQ - Cyclin-Q - Homo sapiens (Human) - CCNQ gene Activating cyclin for the cyclin-associated kinase CDK10. Taurus_UMD|evm.model.AC_000187.1.370 Q99956 DUS9_HUMAN 89.323 0.994751 0.992188 DUSP9 - Dual specificity protein phosphatase 9 - Homo sapiens (Human) - DUSP9 gene Inactivates MAP kinases. Has a specificity for the ERK family. Taurus_UMD|evm.model.AC_000187.1.371 Q9QYK9 KCC1B_MOUSE 94.169 0.994169 1 Pnck - Calcium/calmodulin-dependent protein kinase type 1B - Mus musculus (Mouse) - Pnck gene Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity). Taurus_UMD|evm.model.AC_000187.1.372 O18875 SC6A8_BOVIN 99.636 0.968198 0.891339 SLC6A8 - Sodium- and chloride-dependent creatine transporter 1 - Bos taurus (Bovine) - SLC6A8 gene Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity). Taurus_UMD|evm.model.AC_000187.1.373 Q5R8H3 BAP31_PONAB 88.710 0.99187 1 BCAP31 - B-cell receptor-associated protein 31 - Pongo abelii (Sumatran orangutan) - BCAP31 gene Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (By similarity). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40. In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2. May be involved in CASP8-mediated apoptosis (By similarity). Taurus_UMD|evm.model.AC_000187.1.374 P48410 ABCD1_MOUSE 90.314 0.99187 1.00272 Abcd1 - ATP-binding cassette sub-family D member 1 - Mus musculus (Mouse) - Abcd1 gene Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (By similarity). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:25255441, PubMed:9418970, PubMed:9126326, PubMed:9256488, PubMed:18854420, PubMed:23123468, PubMed:26108493, PubMed:23604518, PubMed:25583114). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance (PubMed:11875044, PubMed:26108493, PubMed:15489218). Controls also the cellular response to oxidative stress by regulating mitochondrial function like, mitochondrial oxidative phosphorylation and depolarization (PubMed:25583114, PubMed:23604518, PubMed:18344354, PubMed:22521832). And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (PubMed:18723473). Taurus_UMD|evm.model.AC_000187.1.375 Q9ULL4 PLXB3_HUMAN 83.983 0.980084 0.999476 PLXNB3 - Plexin-B3 precursor - Homo sapiens (Human) - PLXNB3 gene Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. Taurus_UMD|evm.model.AC_000187.1.376 B8Y466 SRPK3_PIG 93.907 0.916118 1.0742 SRPK3 - SRSF protein kinase 3 - Sus scrofa (Pig) - SRPK3 gene Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity). Taurus_UMD|evm.model.AC_000187.1.377 Q58CP0 IDH3G_BOVIN 100.000 0.994911 1.00255 IDH3G - Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial precursor - Bos taurus (Bovine) - IDH3G gene Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Taurus_UMD|evm.model.AC_000187.1.378 Q2TBX5 SSRD_BOVIN 99.422 0.988506 1.01163 SSR4 - Translocon-associated protein subunit delta precursor - Bos taurus (Bovine) - SSR4 gene TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Taurus_UMD|evm.model.AC_000187.1.379 Q76G19 PDZD4_HUMAN 90.653 0.997442 1.01691 PDZD4 - PDZ domain-containing protein 4 - Homo sapiens (Human) - PDZD4 gene Taurus_UMD|evm.model.AC_000187.1.380 A5JSS2 RL21_CAPHI 98.125 0.987578 1.00625 RPL21 - 60S ribosomal protein L21 - Capra hircus (Goat) - RPL21 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000187.1.381 P32004 L1CAM_HUMAN 89.181 0.998405 0.997613 L1CAM - Neural cell adhesion molecule L1 precursor - Homo sapiens (Human) - L1CAM gene Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. Taurus_UMD|evm.model.AC_000187.1.382 P48044 V2R_BOVIN 100.000 0.994609 1.0027 AVPR2 - Vasopressin V2 receptor - Bos taurus (Bovine) - AVPR2 gene Receptor for arginine vasopressin (PubMed:7698346, PubMed:8257689). The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity). Taurus_UMD|evm.model.AC_000187.1.383 P98171 RHG04_HUMAN 85.399 0.997899 1.00634 ARHGAP4 - Rho GTPase-activating protein 4 - Homo sapiens (Human) - ARHGAP4 gene Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. Taurus_UMD|evm.model.AC_000187.1.384 Q2KI14 NAA10_BOVIN 98.734 0.45614 0.72766 NAA10 - N-alpha-acetyltransferase 10 - Bos taurus (Bovine) - NAA10 gene Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development. Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX. Acetylates HIST1H4A. Acts as a negative regulator of sister chromatid cohesion during mitosis. Taurus_UMD|evm.model.AC_000187.1.385 O18921 RENBP_CANLF 91.429 0.0776256 12.5143 RENBP - N-acylglucosamine 2-epimerase - Canis lupus familiaris (Dog) - RENBP gene Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). Taurus_UMD|evm.model.AC_000187.1.386 P51611 HCFC1_MESAU 88.320 0.984789 0.97512 HCFC1 - Host cell factor 1 - Mesocricetus auratus (Golden hamster) - HCFC1 gene Involved in control of the cell cycle (PubMed:9087427). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (By similarity). Coactivator for EGR2 and GABP2 (By similarity). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription respectively) together (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). Recruits KMT2E to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (By similarity). Taurus_UMD|evm.model.AC_000187.1.387 Q0VCM2 TM187_BOVIN 100.000 0.992218 1.00391 TMEM187 - Transmembrane protein 187 - Bos taurus (Bovine) - TMEM187 gene transport vesicle Taurus_UMD|evm.model.AC_000187.1.388 Q2LGB3 IRAK1_BOVIN 100.000 0.947814 0.987465 IRAK1 - Interleukin-1 receptor-associated kinase 1 - Bos taurus (Bovine) - IRAK1 gene Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3 (By similarity). Taurus_UMD|evm.model.AC_000187.1.389 Q95LG8 MECP2_MACFA 95.607 0.889925 1.10288 MECP2 - Methyl-CpG-binding protein 2 - Macaca fascicularis (Crab-eating macaque) - MECP2 gene Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). Taurus_UMD|evm.model.AC_000187.1.390 Q3SYU2 EF2_BOVIN 83.406 0.995272 0.493007 EEF2 - Elongation factor 2 - Bos taurus (Bovine) - EEF2 gene Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). Taurus_UMD|evm.model.AC_000187.1.391 Q3SYU2 EF2_BOVIN 92.625 0.994118 0.39627 EEF2 - Elongation factor 2 - Bos taurus (Bovine) - EEF2 gene Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). Taurus_UMD|evm.model.AC_000187.1.392 Q9BGI7 OPSR_BOVIN 100.000 0.994521 1.00275 OPN1LW - Long-wave-sensitive opsin 1 - Bos taurus (Bovine) - OPN1LW gene Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. Taurus_UMD|evm.model.AC_000187.1.393 O15482 TEX28_HUMAN 62.195 0.995122 1 TEX28 - Testis-specific protein TEX28 - Homo sapiens (Human) - TEX28 gene endomembrane system Taurus_UMD|evm.model.AC_000187.1.394 Q2NL26 TKTL1_BOVIN 100.000 0.99665 1.00168 TKTL1 - Transketolase-like protein 1 - Bos taurus (Bovine) - TKTL1 gene Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Taurus_UMD|evm.model.AC_000187.1.396 P21333 FLNA_HUMAN 97.734 0.971406 0.977711 FLNA - Filamin-A - Homo sapiens (Human) - FLNA gene Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). Taurus_UMD|evm.model.AC_000187.1.397 O08579 EMD_MOUSE 85.441 0.992366 1.01158 Emd - Emerin - Mus musculus (Mouse) - Emd gene Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C (By similarity). Taurus_UMD|evm.model.AC_000187.1.399 A8D8X1 RL10_SHEEP 100.000 0.603399 1.64953 RPL10 - 60S ribosomal protein L10 - Ovis aries (Sheep) - RPL10 gene Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development. Taurus_UMD|evm.model.AC_000187.1.400 Q2QDE9 DNSL1_BOVIN 99.606 0.992157 0.806962 DNASE1L1 - Deoxyribonuclease-1-like 1 precursor - Bos taurus (Bovine) - DNASE1L1 gene nucleus, deoxyribonuclease I activity, DNA binding, DNA catabolic process, DNA catabolic process, endonucleolytic Taurus_UMD|evm.model.AC_000187.1.401 Q6IV78 TAZ_SAISC 98.456 0.984733 1 TAZ - Tafazzin - Saimiri sciureus (Common squirrel monkey) - TAZ gene Acyltransferase which is required to maintain the composition of the phospholipid cardiolipin, a key component of the mitochondrial inner membrane (By similarity). Required for the initiation of mitophagy (By similarity). Required to ensure progression of spermatocytes through meiosis (By similarity). Taurus_UMD|evm.model.AC_000187.1.402 P40682 VAS1_BOVIN 100.000 0.995736 1.00214 ATP6AP1 - V-type proton ATPase subunit S1 precursor - Bos taurus (Bovine) - ATP6AP1 gene Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). Taurus_UMD|evm.model.AC_000187.1.403 P21856 GDIA_BOVIN 100.000 0.995536 1.00224 GDI1 - Rab GDP dissociation inhibitor alpha - Bos taurus (Bovine) - GDI1 gene Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. Taurus_UMD|evm.model.AC_000187.1.404 Q9WV03 FA50A_MOUSE 97.929 0.346351 2.87021 Fam50a - Protein FAM50A - Mus musculus (Mouse) - Fam50a gene Probably involved in the regulation of pre-mRNA splicing. Taurus_UMD|evm.model.AC_000187.1.405 P51805 PLXA3_HUMAN 94.621 0.998371 0.656334 PLXNA3 - Plexin-A3 precursor - Homo sapiens (Human) - PLXNA3 gene Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Taurus_UMD|evm.model.AC_000187.1.406 B2KIK3 UBL4A_RHIFE 88.125 0.806122 1.225 UBL4A - Ubiquitin-like protein 4A - Rhinolophus ferrumequinum (Greater horseshoe bat) - UBL4A gene As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. Taurus_UMD|evm.model.AC_000187.1.407 Q0V8N6 P3_BOVIN 100.000 0.995816 1.0021 SLC10A3 - P3 protein - Bos taurus (Bovine) - SLC10A3 gene The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions. Taurus_UMD|evm.model.AC_000187.1.408 P98173 FAM3A_HUMAN 90.566 0.95 0.956522 FAM3A - Protein FAM3A precursor - Homo sapiens (Human) - FAM3A gene May act as a defensin against invading fungal microorganisms. Taurus_UMD|evm.model.AC_000187.1.409 O55044 G6PD_CRIGR 95.340 0.92446 1.07961 G6PD - Glucose-6-phosphate 1-dehydrogenase - Cricetulus griseus (Chinese hamster) - G6PD gene Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes. Taurus_UMD|evm.model.AC_000187.1.410 Q95KU9 NEMO_BOVIN 100.000 0.995238 1.00239 IKBKG - NF-kappa-B essential modulator - Bos taurus (Bovine) - IKBKG gene Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways. Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much highr affinity for linear polyubiquitin. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. Taurus_UMD|evm.model.AC_000187.1.411 Q14657 LAGE3_HUMAN 49.123 0.166172 2.35664 LAGE3 - EKC/KEOPS complex subunit LAGE3 - Homo sapiens (Human) - LAGE3 gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex. Taurus_UMD|evm.model.AC_000187.1.414 Q8NDT2 RB15B_HUMAN 83.741 0.971242 0.859551 RBM15B - Putative RNA-binding protein 15B - Homo sapiens (Human) - RBM15B gene RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). Taurus_UMD|evm.model.AC_000187.1.415 Q14657 LAGE3_HUMAN 49.367 0.448276 1.21678 LAGE3 - EKC/KEOPS complex subunit LAGE3 - Homo sapiens (Human) - LAGE3 gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex. Taurus_UMD|evm.model.AC_000187.1.416 P42658 DPP6_HUMAN 80.952 0.137584 0.344509 DPP6 - Dipeptidyl aminopeptidase-like protein 6 - Homo sapiens (Human) - DPP6 gene Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821). Taurus_UMD|evm.model.AC_000187.1.417 Q7TPM1 PRC2B_MOUSE 56.034 0.116248 0.509421 Prrc2b - Protein PRRC2B - Mus musculus (Mouse) - Prrc2b gene cell differentiation, in utero embryonic development Taurus_UMD|evm.model.AC_000187.1.418 Q9CR70 LAGE3_MOUSE 37.143 0.428571 1.08784 Lage3 - EKC/KEOPS complex subunit Lage3 - Mus musculus (Mouse) - Lage3 gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex. Taurus_UMD|evm.model.AC_000187.1.419 P0DME0 SETLP_HUMAN 83.019 0.312883 0.539735 SETSIP - Protein SETSIP - Homo sapiens (Human) - SETSIP gene Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cells into endothelial cells and the formation of vascular-like tubes (in vitro). Involved in the transcription induction of vascular endothelial-cadherin (VE-cadherin) expression. Associates to the VE-cadherin gene promoter. Taurus_UMD|evm.model.AC_000187.1.420 A5PKC7 CX049_BOVIN 39.286 0.598837 0.322097 Uncharacterized protein CXorf49 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000187.1.421 Q9CR70 LAGE3_MOUSE 45.570 0.865169 0.601351 Lage3 - EKC/KEOPS complex subunit Lage3 - Mus musculus (Mouse) - Lage3 gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex. Taurus_UMD|evm.model.AC_000187.1.422 P43362 MAGA9_HUMAN 48.045 0.55625 1.01587 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.425 Q9CR70 LAGE3_MOUSE 44.706 0.417085 1.34459 Lage3 - EKC/KEOPS complex subunit Lage3 - Mus musculus (Mouse) - Lage3 gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex. Taurus_UMD|evm.model.AC_000187.1.426 Q5JSZ5 PRC2B_HUMAN 80.000 0.264574 0.100045 PRRC2B - Protein PRRC2B - Homo sapiens (Human) - PRRC2B gene RNA binding, cell differentiation Taurus_UMD|evm.model.AC_000187.1.427 Q9NQV7 PRDM9_HUMAN 68.908 0.911765 0.380313 PRDM9 - Histone-lysine N-methyltransferase PRDM9 - Homo sapiens (Human) - PRDM9 gene Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:24634223, PubMed:24095733, PubMed:26833727). Also can methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24095733, PubMed:24634223, PubMed:26833727). Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (By similarity). During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:26833727). Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (By similarity). During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema. EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity). In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (By similarity). Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (By similarity). In addition performs automethylation (By similarity). Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (By similarity). Taurus_UMD|evm.model.AC_000187.1.428 A0A1B0GWH4 HSFX3_HUMAN 58.904 0.734694 0.294294 HSFX3 - Heat shock transcription factor, X-linked member 3 - Homo sapiens (Human) - HSFX3 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000187.1.429 P43362 MAGA9_HUMAN 39.091 0.4 0.666667 MAGEA9 - Melanoma-associated antigen 9 - Homo sapiens (Human) - MAGEA9 gene Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Taurus_UMD|evm.model.AC_000187.1.430 Q5RAX6 EOLAL_PONAB 64.706 0.666667 0.797468 EOLA-like protein - Pongo abelii (Sumatran orangutan) Taurus_UMD|evm.model.AC_000187.1.431 A0A1B0GWH4 HSFX3_HUMAN 52.000 0.905028 1.07508 HSFX3 - Heat shock transcription factor, X-linked member 3 - Homo sapiens (Human) - HSFX3 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000187.1.432 P43357 MAGA3_HUMAN 39.896 0.64876 0.770701 MAGEA3 - Melanoma-associated antigen 3 - Homo sapiens (Human) - MAGEA3 gene Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Taurus_UMD|evm.model.AC_000187.1.434 Q8MID1 TF2LX_MIOTA 57.746 0.831325 0.333333 TGIF2LX - Homeobox protein TGIF2LX - Miopithecus talapoin (Angolan talapoin) - TGIF2LX gene May have a transcription role in testis. Taurus_UMD|evm.model.AC_000187.1.435 Q8MIE9 TF2LX_GORGO 57.576 0.907407 0.448133 TGIF2LX - Homeobox protein TGIF2LX - Gorilla gorilla gorilla (Western lowland gorilla) - TGIF2LX gene May have a transcription role in testis. Taurus_UMD|evm.model.AC_000187.1.436 Q2HJG5 VPS35_BOVIN 81.486 0.996909 0.812814 VPS35 - Vacuolar protein sorting-associated protein 35 - Bos taurus (Bovine) - VPS35 gene Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for endosomal localization of WASHC2. Mediates the association of the CSC with the WASH complex via WASHC2. Required for the endosomal localization of TBC1D5 (By similarity). Taurus_UMD|evm.model.AC_000187.1.437 P60050 PABP5_PONPY 96.850 0.992167 1.00262 PABPC5 - Polyadenylate-binding protein 5 - Pongo pygmaeus (Bornean orangutan) - PABPC5 gene Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). Taurus_UMD|evm.model.AC_000187.1.438 Q8IYR6 TEFF1_HUMAN 84.252 0.993884 0.860526 TMEFF1 - Tomoregulin-1 precursor - Homo sapiens (Human) - TMEFF1 gene May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers. Taurus_UMD|evm.model.AC_000187.1.439 P62840 UB2D2_XENLA 65.385 0.984848 0.44898 ube2d2 - Ubiquitin-conjugating enzyme E2 D2 - Xenopus laevis (African clawed frog) - ube2d2 gene Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Taurus_UMD|evm.model.AC_000187.1.440 Q9Y3E1 HDGR3_HUMAN 85.915 0.404624 0.852217 HDGFL3 - Hepatoma-derived growth factor-related protein 3 - Homo sapiens (Human) - HDGFL3 gene Enhances DNA synthesis and may play a role in cell proliferation. Taurus_UMD|evm.model.AC_000187.1.443 D3Z8Y2 DPPA4_RAT 62.791 0.327731 0.400673 Dppa4 - Developmental pluripotency-associated protein 4 - Rattus norvegicus (Rat) - Dppa4 gene May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic stem (ES) cells into a primitive ectoderm lineage (By similarity). Taurus_UMD|evm.model.AC_000187.1.446 Q99457 NP1L3_HUMAN 63.244 0.997506 0.79249 NAP1L3 - Nucleosome assembly protein 1-like 3 - Homo sapiens (Human) - NAP1L3 gene chromatin, nucleus, chromatin binding, histone binding, nucleosome assembly Taurus_UMD|evm.model.AC_000187.1.447 Q8N9E0 F133A_HUMAN 94.048 0.332 1.00806 FAM133A - Protein FAM133A - Homo sapiens (Human) - FAM133A gene Taurus_UMD|evm.model.AC_000187.1.454 P42174 DHE3_PIG 79.661 0.983193 0.213262 GLUD1 - Glutamate dehydrogenase 1, mitochondrial precursor - Sus scrofa (Pig) - GLUD1 gene Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:8240242). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). Taurus_UMD|evm.model.AC_000187.1.455 P00366 DHE3_BOVIN 83.333 0.990698 0.385305 GLUD1 - Glutamate dehydrogenase 1, mitochondrial precursor - Bos taurus (Bovine) - GLUD1 gene Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:4365183, PubMed:14659072). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). Taurus_UMD|evm.model.AC_000187.1.460 P16423 POLR_DROME 29.464 0.383399 0.478713 pol - Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM - Drosophila melanogaster (Fruit fly) - pol gene Taurus_UMD|evm.model.AC_000187.1.461 O15479 MAGB2_HUMAN 53.927 0.616883 0.965517 MAGEB2 - Melanoma-associated antigen B2 - Homo sapiens (Human) - MAGEB2 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Taurus_UMD|evm.model.AC_000187.1.462 Q64674 SPEE_MOUSE 45.070 0.92381 0.347682 Srm - Spermidine synthase - Mus musculus (Mouse) - Srm gene Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine (By similarity). Taurus_UMD|evm.model.AC_000187.1.463 Q8ISN9 RS25_BRABE 72.093 0.531646 0.642276 RPS25 - 40S ribosomal protein S25 - Branchiostoma belcheri (Amphioxus) - RPS25 gene Taurus_UMD|evm.model.AC_000187.1.464 Q6ZPY2 SMG5_MOUSE 44.053 0.969027 0.222222 Smg5 - Protein SMG5 - Mus musculus (Mouse) - Smg5 gene Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity (By similarity). Taurus_UMD|evm.model.AC_000187.1.465 O60879 DIAP2_HUMAN 92.210 0.779516 0.63851 DIAPH2 - Protein diaphanous homolog 2 - Homo sapiens (Human) - DIAPH2 gene Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. Taurus_UMD|evm.model.AC_000187.1.466 Q58DT1 RL7_BOVIN 86.290 0.990868 0.883065 RPL7 - 60S ribosomal protein L7 - Bos taurus (Bovine) - RPL7 gene Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). Taurus_UMD|evm.model.AC_000187.1.467 O60879 DIAP2_HUMAN 92.405 0.912791 0.156222 DIAPH2 - Protein diaphanous homolog 2 - Homo sapiens (Human) - DIAPH2 gene Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. Taurus_UMD|evm.model.AC_000187.1.470 P70696 H2B1A_MOUSE 46.491 0.674699 1.30709 H2bc1 - Histone H2B type 1-A - Mus musculus (Mouse) - H2bc1 gene Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (PubMed:23884607, PubMed:28366643). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (PubMed:23884607). In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) (PubMed:28366643). Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (PubMed:23884607). Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000187.1.471 Q8JHJ1 RL35_DANRE 56.716 0.606061 0.804878 rpl35 - 60S ribosomal protein L35 - Danio rerio (Zebrafish) - rpl35 gene Plays an essential role in early embryonic development. May act as a haploinsufficient tumor suppressor. Taurus_UMD|evm.model.AC_000187.1.472 Q8IUQ4 SIAH1_HUMAN 77.143 0.985816 1 SIAH1 - E3 ubiquitin-protein ligase SIAH1 - Homo sapiens (Human) - SIAH1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP (PubMed:10747903, PubMed:11146551, PubMed:11389839, PubMed:11389840, PubMed:11483517, PubMed:11483518, PubMed:11752454, PubMed:12072443). Confers constitutive instability to HIPK2 through proteasomal degradation (PubMed:18536714). It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Has some overlapping function with SIAH2 (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Induces apoptosis in cooperation with PEG3 (By similarity). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus (By similarity). GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Taurus_UMD|evm.model.AC_000187.1.473 Q6P1M9 ARMX5_HUMAN 75.100 0.995943 0.883513 ARMCX5 - Armadillo repeat-containing X-linked protein 5 - Homo sapiens (Human) - ARMCX5 gene Taurus_UMD|evm.model.AC_000187.1.475 Q5JY77 GASP1_HUMAN 62.524 0.998049 0.734767 GPRASP1 - G-protein coupled receptor-associated sorting protein 1 - Homo sapiens (Human) - GPRASP1 gene Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2. Taurus_UMD|evm.model.AC_000187.1.476 Q5JY77 GASP1_HUMAN 78.495 0.844037 0.0781362 GPRASP1 - G-protein coupled receptor-associated sorting protein 1 - Homo sapiens (Human) - GPRASP1 gene Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2. Taurus_UMD|evm.model.AC_000187.1.477 Q5JY77 GASP1_HUMAN 78.505 0.990698 0.154122 GPRASP1 - G-protein coupled receptor-associated sorting protein 1 - Homo sapiens (Human) - GPRASP1 gene Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2. Taurus_UMD|evm.model.AC_000187.1.479 Q5R7U0 GASP2_PONAB 81.183 0.997636 1.00955 GPRASP2 - G-protein coupled receptor-associated sorting protein 2 - Pongo abelii (Sumatran orangutan) - GPRASP2 gene May play a role in regulation of a variety of G-protein coupled receptors. Taurus_UMD|evm.model.AC_000187.1.480 Q9BE11 BHLH9_MACFA 72.401 0.975395 1.04022 BHLHB9 - Protein BHLHb9 - Macaca fascicularis (Crab-eating macaque) - BHLHB9 gene May play a role in the control of cellular aging and survival. Taurus_UMD|evm.model.AC_000187.1.481 Q14657 LAGE3_HUMAN 48.980 0.421053 0.797203 LAGE3 - EKC/KEOPS complex subunit LAGE3 - Homo sapiens (Human) - LAGE3 gene Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex. Taurus_UMD|evm.model.AC_000187.1.483 P78358 CTG1B_HUMAN 41.333 0.240678 1.63889 CTAG1A - Cancer/testis antigen 1 - Homo sapiens (Human) - CTAG1A gene cytoplasm, identical protein binding, positive regulation of transcription by RNA polymerase II, tRNA threonylcarbamoyladenosine metabolic process Taurus_UMD|evm.model.AC_000187.1.484 P78358 CTG1B_HUMAN 40.230 0.455056 0.988889 CTAG1A - Cancer/testis antigen 1 - Homo sapiens (Human) - CTAG1A gene cytoplasm, identical protein binding, positive regulation of transcription by RNA polymerase II, tRNA threonylcarbamoyladenosine metabolic process Taurus_UMD|evm.model.AC_000187.1.485 Q8IV48 ERI1_HUMAN 86.154 0.366516 2.53295 ERI1 - 3'-5' exoribonuclease 1 - Homo sapiens (Human) - ERI1 gene RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. Taurus_UMD|evm.model.AC_000187.1.486 Q2TBV0 BEX2_BOVIN 100.000 0.984496 1.00781 BEX2 - Protein BEX2 - Bos taurus (Bovine) - BEX2 gene Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity). Taurus_UMD|evm.model.AC_000187.1.487 Q0IIM1 RN168_BOVIN 70.866 0.961832 0.228621 RNF168 - E3 ubiquitin-protein ligase RNF168 - Bos taurus (Bovine) - RNF168 gene E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). Taurus_UMD|evm.model.AC_000187.1.488 Q5EA25 SRPX2_BOVIN 99.785 0.995708 1.00215 SRPX2 - Sushi repeat-containing protein SRPX2 precursor - Bos taurus (Bovine) - SRPX2 gene Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation (By similarity). Taurus_UMD|evm.model.AC_000187.1.489 Q32KU6 TSN6_BOVIN 100.000 0.99187 1.00408 TSPAN6 - Tetraspanin-6 - Bos taurus (Bovine) - TSPAN6 gene integral component of plasma membrane Taurus_UMD|evm.model.AC_000187.1.490 Q9H2S6 TNMD_HUMAN 96.541 0.99373 1.00631 TNMD - Tenomodulin - Homo sapiens (Human) - TNMD gene May be an angiogenesis inhibitor. Taurus_UMD|evm.model.AC_000187.1.491 Q8TAB3 PCD19_HUMAN 93.380 0.99818 0.957317 PCDH19 - Protocadherin-19 precursor - Homo sapiens (Human) - PCDH19 gene Potential calcium-dependent cell-adhesion protein. Taurus_UMD|evm.model.AC_000187.1.494 Q9NP60 IRPL2_HUMAN 96.809 0.664286 0.204082 IL1RAPL2 - X-linked interleukin-1 receptor accessory protein-like 2 precursor - Homo sapiens (Human) - IL1RAPL2 gene glutamatergic synapse, plasma membrane, interleukin-1 receptor activity, central nervous system development, regulation of presynapse assembly Taurus_UMD|evm.model.AC_000187.1.495 Q9BXU2 TX13B_HUMAN 60.215 0.45297 1.29487 TEX13B - Testis-expressed protein 13B - Homo sapiens (Human) - TEX13B gene Taurus_UMD|evm.model.AC_000187.1.497 A4IFL2 SMAGP_BOVIN 61.111 0.956522 0.71134 SMAGP - Small cell adhesion glycoprotein - Bos taurus (Bovine) - SMAGP gene May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation (By similarity). Taurus_UMD|evm.model.AC_000187.1.498 P63170 DYL1_RAT 96.629 0.977778 1.01124 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Taurus_UMD|evm.model.AC_000187.1.499 Q9NP60 IRPL2_HUMAN 94.872 0.961798 0.648688 IL1RAPL2 - X-linked interleukin-1 receptor accessory protein-like 2 precursor - Homo sapiens (Human) - IL1RAPL2 gene glutamatergic synapse, plasma membrane, interleukin-1 receptor activity, central nervous system development, regulation of presynapse assembly Taurus_UMD|evm.model.AC_000187.1.500 Q7Z2Y5 NRK_HUMAN 95.904 0.945205 0.276865 NRK - Nik-related protein kinase - Homo sapiens (Human) - NRK gene May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). Taurus_UMD|evm.model.AC_000187.1.501 Q7Z2Y5 NRK_HUMAN 78.184 0.992933 0.536662 NRK - Nik-related protein kinase - Homo sapiens (Human) - NRK gene May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). Taurus_UMD|evm.model.AC_000187.1.502 Q7Z2Y5 NRK_HUMAN 91.713 0.779221 0.146018 NRK - Nik-related protein kinase - Homo sapiens (Human) - NRK gene May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). Taurus_UMD|evm.model.AC_000187.1.503 Q9TT36 THBG_BOVIN 99.513 0.995146 1.00243 SERPINA7 - Thyroxine-binding globulin precursor - Bos taurus (Bovine) - SERPINA7 gene Major thyroid hormone transport protein in serum. Taurus_UMD|evm.model.AC_000187.1.505 Q5H9M0 PWP3B_HUMAN 76.791 0.997122 0.998563 PWWP3B - PWWP domain-containing DNA repair factor 3B - Homo sapiens (Human) - PWWP3B gene extracellular exosome Taurus_UMD|evm.model.AC_000187.1.506 Q5R4D4 NP1L1_PONAB 62.500 0.0714286 1.39642 NAP1L1 - Nucleosome assembly protein 1-like 1 precursor - Pongo abelii (Sumatran orangutan) - NAP1L1 gene Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). Taurus_UMD|evm.model.AC_000187.1.515 Q95SX7 RTBS_DROME 30.464 0.710145 0.228477 RTase - Probable RNA-directed DNA polymerase from transposon BS - Drosophila melanogaster (Fruit fly) - RTase gene RNA-directed DNA polymerase activity, transposition, DNA-mediated Taurus_UMD|evm.model.AC_000187.1.516 Q96C24 SYTL4_HUMAN 92.399 0.997024 1.00149 SYTL4 - Synaptotagmin-like protein 4 - Homo sapiens (Human) - SYTL4 gene Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). Taurus_UMD|evm.model.AC_000187.1.517 Q8HXM1 CSTF2_BOVIN 96.622 0.996627 1.03671 CSTF2 - Cleavage stimulation factor subunit 2 - Bos taurus (Bovine) - CSTF2 gene One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity). Taurus_UMD|evm.model.AC_000187.1.518 Q9Y5S8 NOX1_HUMAN 80.142 0.996234 0.941489 NOX1 - NADPH oxidase 1 - Homo sapiens (Human) - NOX1 gene NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. Taurus_UMD|evm.model.AC_000187.1.519 Q6PP77 XKR2_HUMAN 93.541 0.995556 1.00223 XKRX - XK-related protein 2 - Homo sapiens (Human) - XKRX gene Taurus_UMD|evm.model.AC_000187.1.520 Q5E9T5 TM35A_BOVIN 100.000 0.303448 3.27684 TMEM35A - Novel acetylcholine receptor chaperone - Bos taurus (Bovine) - TMEM35A gene Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (By similarity). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (By similarity). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (By similarity). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (By similarity). Taurus_UMD|evm.model.AC_000187.1.521 Q92674 CENPI_HUMAN 81.611 0.997238 0.957672 CENPI - Centromere protein I - Homo sapiens (Human) - CENPI gene Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone. Taurus_UMD|evm.model.AC_000187.1.522 Q13474 DRP2_HUMAN 94.357 0.997912 1.00104 DRP2 - Dystrophin-related protein 2 - Homo sapiens (Human) - DRP2 gene Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system. Taurus_UMD|evm.model.AC_000187.1.523 Q5H9L4 TAF7L_HUMAN 59.009 0.993151 0.948052 TAF7L - Transcription initiation factor TFIID subunit 7-like - Homo sapiens (Human) - TAF7L gene Probably functions as a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in spermatogenesis (By similarity). Taurus_UMD|evm.model.AC_000187.1.524 Q3ZBS8 TIM8A_BOVIN 100.000 0.979592 1.01031 TIMM8A - Mitochondrial import inner membrane translocase subunit Tim8 A - Bos taurus (Bovine) - TIMM8A gene Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity). Taurus_UMD|evm.model.AC_000187.1.525 Q06187 BTK_HUMAN 98.634 0.99697 1.00152 BTK - Tyrosine-protein kinase BTK - Homo sapiens (Human) - BTK gene Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis. Taurus_UMD|evm.model.AC_000187.1.526 P83883 RL36A_RAT 100.000 0.734266 1.34906 Rpl36a - 60S ribosomal protein L36a - Rattus norvegicus (Rat) - Rpl36a gene cytosolic large ribosomal subunit, nucleus, response to organic substance, response to retinoic acid Taurus_UMD|evm.model.AC_000187.1.527 P06280 AGAL_HUMAN 81.138 0.646602 1.20047 GLA - Alpha-galactosidase A precursor - Homo sapiens (Human) - GLA gene Catalyzes the hydrolysis of glycosphingolipids and participates to their degradation in the lysosome. Taurus_UMD|evm.model.AC_000187.1.528 Q3SZF3 HNRH2_BOVIN 99.777 0.995556 1.00223 HNRNPH2 - Heterogeneous nuclear ribonucleoprotein H2 - Bos taurus (Bovine) - HNRNPH2 gene This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity). Taurus_UMD|evm.model.AC_000187.1.529 Q9UH62 ARMX3_HUMAN 62.791 0.0181191 6.11609 ARMCX3 - Armadillo repeat-containing X-linked protein 3 - Homo sapiens (Human) - ARMCX3 gene Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. Taurus_UMD|evm.model.AC_000187.1.530 P67829 KC1A_SHEEP 78.348 0.964088 1.11385 CSNK1A1 - Casein kinase I isoform alpha - Ovis aries (Sheep) - CSNK1A1 gene Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. Taurus_UMD|evm.model.AC_000187.1.532 Q9P291 ARMX1_HUMAN 85.421 0.964758 1.00221 ARMCX1 - Armadillo repeat-containing X-linked protein 1 - Homo sapiens (Human) - ARMCX1 gene Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1. Taurus_UMD|evm.model.AC_000187.1.533 Q7L4S7 ARMX6_HUMAN 74.086 0.990066 1.00667 ARMCX6 - Protein ARMCX6 - Homo sapiens (Human) - ARMCX6 gene May regulate the dynamics and distribution of mitochondria in neural cells. Taurus_UMD|evm.model.AC_000187.1.534 Q5R9J3 ARMX3_PONAB 95.515 0.994737 1.00264 ARMCX3 - Armadillo repeat-containing X-linked protein 3 - Pongo abelii (Sumatran orangutan) - ARMCX3 gene Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. Taurus_UMD|evm.model.AC_000187.1.535 Q6A058 ARMX2_MOUSE 86.279 0.701639 0.778061 Armcx2 - Armadillo repeat-containing X-linked protein 2 - Mus musculus (Mouse) - Armcx2 gene May regulate the dynamics and distribution of mitochondria in neural cells. Taurus_UMD|evm.model.AC_000187.1.536 Q9GZY0 NXF2_HUMAN 65.700 0.894356 1.10383 NXF2 - Nuclear RNA export factor 2 - Homo sapiens (Human) - NXF2 gene Involved in the export of mRNA from the nucleus to the cytoplasm. Taurus_UMD|evm.model.AC_000187.1.537 Q28EG9 ZMAT1_XENTR 71.795 0.0475594 1.44485 zmat1 - Zinc finger matrin-type protein 1 - Xenopus tropicalis (Western clawed frog) - zmat1 gene Taurus_UMD|evm.model.AC_000187.1.538 Q3ZBJ9 BEX5_BOVIN 100.000 0.685185 1.44643 BEX5 - Protein BEX5 - Bos taurus (Bovine) - BEX5 gene cytoplasm, signaling receptor binding, signal transduction Taurus_UMD|evm.model.AC_000187.1.540 P78395 PRAME_HUMAN 33.974 0.968017 0.921415 PRAME - Melanoma antigen preferentially expressed in tumors - Homo sapiens (Human) - PRAME gene Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. Taurus_UMD|evm.model.AC_000187.1.541 B4DZS4 T11X1_HUMAN 75.094 0.515625 1.64103 TCP11X1 - T-complex protein 11 X-linked protein 1 - Homo sapiens (Human) - TCP11X1 gene acrosomal vesicle, sperm flagellum, protein kinase A signaling, regulation of sperm capacitation, signal transduction Taurus_UMD|evm.model.AC_000187.1.542 Q9H4D5 NXF3_HUMAN 70.536 0.0454732 4.59699 NXF3 - Nuclear RNA export factor 3 - Homo sapiens (Human) - NXF3 gene May function as a tissue-specific nuclear mRNA export factor. Taurus_UMD|evm.model.AC_000187.1.543 Q9H4D5 NXF3_HUMAN 76.923 0.0114389 6.25612 NXF3 - Nuclear RNA export factor 3 - Homo sapiens (Human) - NXF3 gene May function as a tissue-specific nuclear mRNA export factor. Taurus_UMD|evm.model.AC_000187.1.544 Q9H4D5 NXF3_HUMAN 66.364 0.249428 0.822976 NXF3 - Nuclear RNA export factor 3 - Homo sapiens (Human) - NXF3 gene May function as a tissue-specific nuclear mRNA export factor. Taurus_UMD|evm.model.AC_000187.1.546 P43355 MAGA1_HUMAN 53.782 0.517857 0.724919 MAGEA1 - Melanoma-associated antigen 1 - Homo sapiens (Human) - MAGEA1 gene May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Taurus_UMD|evm.model.AC_000187.1.548 A3KGB4 TBC8B_MOUSE 95.570 0.530405 0.265709 Tbc1d8b - TBC1 domain family member 8B - Mus musculus (Mouse) - Tbc1d8b gene Involved in vesicular recycling, probably as a RAB11B GTPase-activating protein. Taurus_UMD|evm.model.AC_000187.1.549 Q29RU0 RN128_BOVIN 99.768 0.99537 1.00232 RNF128 - E3 ubiquitin-protein ligase RNF128 precursor - Bos taurus (Bovine) - RNF128 gene E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals. Taurus_UMD|evm.model.AC_000187.1.550 Q6NSI4 RADX_HUMAN 71.212 0.997516 0.94152 RADX - RPA-related protein RADX - Homo sapiens (Human) - RADX gene Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897). Taurus_UMD|evm.model.AC_000187.1.551 Q6NSI4 RADX_HUMAN 78.505 0.981567 0.253801 RADX - RPA-related protein RADX - Homo sapiens (Human) - RADX gene Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897). Taurus_UMD|evm.model.AC_000187.1.552 Q9NWD9 BEX4_HUMAN 65.833 0.734568 1.35 BEX4 - Protein BEX4 - Homo sapiens (Human) - BEX4 gene May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability. Taurus_UMD|evm.model.AC_000187.1.553 Q9GZY0 NXF2_HUMAN 52.206 0.560166 0.384984 NXF2 - Nuclear RNA export factor 2 - Homo sapiens (Human) - NXF2 gene Involved in the export of mRNA from the nucleus to the cytoplasm. Taurus_UMD|evm.model.AC_000187.1.554 Q2TBV0 BEX2_BOVIN 82.031 0.984496 1.00781 BEX2 - Protein BEX2 - Bos taurus (Bovine) - BEX2 gene Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity). Taurus_UMD|evm.model.AC_000187.1.555 Q3ZBJ6 BEX3_BOVIN 100.000 0.982301 1.00893 BEX3 - Protein BEX3 - Bos taurus (Bovine) - BEX3 gene May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). Taurus_UMD|evm.model.AC_000187.1.557 Q9H4D5 NXF3_HUMAN 50.427 0.96087 0.86629 NXF3 - Nuclear RNA export factor 3 - Homo sapiens (Human) - NXF3 gene May function as a tissue-specific nuclear mRNA export factor. Taurus_UMD|evm.model.AC_000187.1.558 Q9NWD9 BEX4_HUMAN 65.833 0.983471 1.00833 BEX4 - Protein BEX4 - Homo sapiens (Human) - BEX4 gene May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability. Taurus_UMD|evm.model.AC_000187.1.559 Q3T020 TCAL8_BOVIN 100.000 0.983051 1.00855 TCEAL8 - Transcription elongation factor A protein-like 8 - Bos taurus (Bovine) - TCEAL8 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.560 Q969E4 TCAL3_HUMAN 66.387 0.674286 0.875 TCEAL3 - Transcription elongation factor A protein-like 3 - Homo sapiens (Human) - TCEAL3 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.561 Q0IIM1 RN168_BOVIN 69.512 0.618321 0.228621 RNF168 - E3 ubiquitin-protein ligase RNF168 - Bos taurus (Bovine) - RNF168 gene E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). Taurus_UMD|evm.model.AC_000187.1.562 P62828 RAN_RAT 88.889 0.98995 0.921296 Ran - GTP-binding nuclear protein Ran - Rattus norvegicus (Rat) - Ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. Taurus_UMD|evm.model.AC_000187.1.563 Q8K3F3 PP14B_RAT 88.889 0.790323 0.843537 Ppp1r14b - Protein phosphatase 1 regulatory subunit 14B - Rattus norvegicus (Rat) - Ppp1r14b gene Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity). Taurus_UMD|evm.model.AC_000187.1.565 Q96EI5 TCAL4_HUMAN 62.445 0.991266 1.06512 TCEAL4 - Transcription elongation factor A protein-like 4 - Homo sapiens (Human) - TCEAL4 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.566 Q2KIJ9 TCAL1_BOVIN 100.000 0.741784 1.33962 TCEAL1 - Transcription elongation factor A protein-like 1 - Bos taurus (Bovine) - TCEAL1 gene May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. Does not bind DNA directly (By similarity). Taurus_UMD|evm.model.AC_000187.1.567 Q5R905 MO4L2_PONAB 96.181 0.993056 1 MORF4L2 - Mortality factor 4-like protein 2 - Pongo abelii (Sumatran orangutan) - MORF4L2 gene Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity). Taurus_UMD|evm.model.AC_000187.1.568 Q61603 GLRA4_MOUSE 96.718 0.995633 1.00439 Glra4 - Glycine receptor subunit alpha-4 precursor - Mus musculus (Mouse) - Glra4 gene Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine (PubMed:10762330). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (Probable). Taurus_UMD|evm.model.AC_000187.1.569 P04116 MYPR_BOVIN 100.000 0.992806 1.00361 PLP1 - Myelin proteolipid protein - Bos taurus (Bovine) - PLP1 gene This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. Taurus_UMD|evm.model.AC_000187.1.570 Q5R4W9 RAB9B_PONAB 99.502 0.990099 1.00498 RAB9B - Ras-related protein Rab-9B - Pongo abelii (Sumatran orangutan) - RAB9B gene Involved in the transport of proteins between the endosomes and the trans Golgi network. Taurus_UMD|evm.model.AC_000187.1.571 P0C1H6 H2BFM_HUMAN 52.222 0.453125 1.24675 H2BW2 - Histone H2B type F-M - Homo sapiens (Human) - H2BW2 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000187.1.573 P22314 UBA1_HUMAN 84.298 0.31746 0.357278 UBA1 - Ubiquitin-like modifier-activating enzyme 1 - Homo sapiens (Human) - UBA1 gene Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). Taurus_UMD|evm.model.AC_000187.1.574 Q96LI6 HSFY1_HUMAN 51.220 0.29368 0.670823 HSFY1 - Heat shock transcription factor, Y-linked - Homo sapiens (Human) - HSFY1 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000187.1.575 Q7Z2G1 H2BWT_HUMAN 46.457 0.706587 0.954286 H2BW1 - Histone H2B type W-T - Homo sapiens (Human) - H2BW1 gene Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function. Taurus_UMD|evm.model.AC_000187.1.576 Q7Z2G1 H2BWT_HUMAN 46.457 0.706587 0.954286 H2BW1 - Histone H2B type W-T - Homo sapiens (Human) - H2BW1 gene Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function. Taurus_UMD|evm.model.AC_000187.1.577 Q7Z2G1 H2BWT_HUMAN 46.457 0.706587 0.954286 H2BW1 - Histone H2B type W-T - Homo sapiens (Human) - H2BW1 gene Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function. Taurus_UMD|evm.model.AC_000187.1.578 P70696 H2B1A_MOUSE 54.464 0.670732 1.29134 H2bc1 - Histone H2B type 1-A - Mus musculus (Mouse) - H2bc1 gene Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (PubMed:23884607, PubMed:28366643). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (PubMed:23884607). In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) (PubMed:28366643). Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (PubMed:23884607). Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000187.1.579 Q86YH2 Z280B_HUMAN 67.347 0.220211 1.22099 ZNF280B - Zinc finger protein 280B - Homo sapiens (Human) - ZNF280B gene May function as a transcription factor. Taurus_UMD|evm.model.AC_000187.1.580 O19110 TSPY1_BOVIN 94.595 0.789286 0.883281 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000187.1.581 Q5H9E4 S2553_HUMAN 91.148 0.990228 1 SLC25A53 - Solute carrier family 25 member 53 - Homo sapiens (Human) - SLC25A53 gene Taurus_UMD|evm.model.AC_000187.1.582 P0CG32 ZCC18_HUMAN 73.881 0.984962 0.330025 ZCCHC18 - Zinc finger CCHC domain-containing protein 18 - Homo sapiens (Human) - ZCCHC18 gene nucleus Taurus_UMD|evm.model.AC_000187.1.583 Q6PEV8 F199X_HUMAN 98.454 0.994859 1.00258 FAM199X - Protein FAM199X - Homo sapiens (Human) - FAM199X gene Taurus_UMD|evm.model.AC_000187.1.584 Q26602 SMOX3_SCHMA 60.938 0.225 0.972222 SMOX-3 - Homeobox protein SMOX-3 - Schistosoma mansoni (Blood fluke) - SMOX-3 gene Taurus_UMD|evm.model.AC_000187.1.586 Q9BE31 RHG12_MACFA 82.500 0.44382 0.210153 ARHGAP12 - Rho GTPase-activating protein 12 - Macaca fascicularis (Crab-eating macaque) - ARHGAP12 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Taurus_UMD|evm.model.AC_000187.1.587 Q9QUS6 TRIM1_MOUSE 97.166 0.504098 0.692199 Mid2 - Probable E3 ubiquitin-protein ligase MID2 - Mus musculus (Mouse) - Mid2 gene May play a role in microtubule stabilization. Taurus_UMD|evm.model.AC_000187.1.589 Q9EQZ1 T22D3_RAT 96.396 0.709677 1.15672 Tsc22d3 - TSC22 domain family protein 3 - Rattus norvegicus (Rat) - Tsc22d3 gene Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity). Taurus_UMD|evm.model.AC_000187.1.590 P60892 PRPS1_RAT 100.000 0.99373 1.00314 Prps1 - Ribose-phosphate pyrophosphokinase 1 - Rattus norvegicus (Rat) - Prps1 gene Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Taurus_UMD|evm.model.AC_000187.1.591 Q5JV73 FRPD3_HUMAN 90.151 0.982496 0.978453 FRMPD3 - FERM and PDZ domain-containing protein 3 - Homo sapiens (Human) - FRMPD3 gene plasma membrane, secretory granule membrane, tertiary granule membrane, neutrophil degranulation Taurus_UMD|evm.model.AC_000187.1.592 Q8TE76 MORC4_HUMAN 87.953 0.997863 0.998933 MORC4 - MORC family CW-type zinc finger protein 4 - Homo sapiens (Human) - MORC4 gene Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). Taurus_UMD|evm.model.AC_000187.1.593 Q765P1 CLD2_BOVIN 100.000 0.991342 1.00435 CLDN2 - Claudin-2 - Bos taurus (Bovine) - CLDN2 gene Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Taurus_UMD|evm.model.AC_000187.1.594 Q0D2K3 RIPP1_HUMAN 77.670 0.534031 1.2649 RIPPLY1 - Protein ripply1 - Homo sapiens (Human) - RIPPLY1 gene Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites (By similarity). Taurus_UMD|evm.model.AC_000187.1.595 Q0IIM8 TBC8B_HUMAN 90.542 0.9729 0.658929 TBC1D8B - TBC1 domain family member 8B - Homo sapiens (Human) - TBC1D8B gene Involved in vesicular recycling, probably as a RAB11B GTPase-activating protein. Taurus_UMD|evm.model.AC_000187.1.596 Q9NQM4 DAAF6_HUMAN 68.900 0.990291 0.962617 DNAAF6 - Dynein axonemal assembly factor 6 - Homo sapiens (Human) - DNAAF6 gene Plays a role in cytoplasmic pre-assembly of axonemal dynein. Taurus_UMD|evm.model.AC_000187.1.597 Q9H1M0 N62CL_HUMAN 65.000 0.455738 1.65761 NUP62CL - Nucleoporin-62 C-terminal-like protein - Homo sapiens (Human) - NUP62CL gene nuclear pore central transport channel, phospholipid binding, structural constituent of nuclear pore, protein import into nucleus, RNA export from nucleus Taurus_UMD|evm.model.AC_000187.1.598 Q96IZ5 RBM41_HUMAN 99.057 0.302594 0.840194 RBM41 - RNA-binding protein 41 - Homo sapiens (Human) - RBM41 gene May bind RNA. Taurus_UMD|evm.model.AC_000187.1.599 Q9QUS6 TRIM1_MOUSE 99.349 0.995671 0.655319 Mid2 - Probable E3 ubiquitin-protein ligase MID2 - Mus musculus (Mouse) - Mid2 gene May play a role in microtubule stabilization. Taurus_UMD|evm.model.AC_000187.1.600 Q96P20 NLRP3_HUMAN 34.302 0.584559 0.262548 NLRP3 - NACHT, LRR and PYD domains-containing protein 3 - Homo sapiens (Human) - NLRP3 gene As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu (PubMed:28847925). Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, cytosolic dsRNA, etc. However, it is unclear what constitutes the direct NLRP3 activator. Activation in presence of cytosolic dsRNA is mediated by DHX33 (PubMed:23871209). Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). Taurus_UMD|evm.model.AC_000187.1.601 Q9BXU2 TX13B_HUMAN 64.674 0.628472 0.923077 TEX13B - Testis-expressed protein 13B - Homo sapiens (Human) - TEX13B gene Taurus_UMD|evm.model.AC_000187.1.602 Q29RR6 VSIG1_BOVIN 99.738 0.994778 1.00262 VSIG1 - V-set and immunoglobulin domain-containing protein 1 precursor - Bos taurus (Bovine) - VSIG1 gene basolateral plasma membrane, maintenance of gastrointestinal epithelium Taurus_UMD|evm.model.AC_000187.1.603 O75832 PSD10_HUMAN 99.111 0.82963 1.19469 PSMD10 - 26S proteasome non-ATPase regulatory subunit 10 - Homo sapiens (Human) - PSMD10 gene Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Taurus_UMD|evm.model.AC_000187.1.604 Q6PZ05 ATG4A_BOVIN 99.749 0.994987 1.00251 ATG4A - Cysteine protease ATG4A - Bos taurus (Bovine) - ATG4A gene Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity). Taurus_UMD|evm.model.AC_000187.1.605 Q14031 CO4A6_HUMAN 82.965 0.979388 1.00414 COL4A6 - Collagen alpha-6(IV) chain precursor - Homo sapiens (Human) - COL4A6 gene Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Taurus_UMD|evm.model.AC_000187.1.606 P0C7X4 FHL19_HUMAN 58.696 0.978495 0.462687 FTH1P19 - Putative ferritin heavy polypeptide-like 19 - Homo sapiens (Human) - FTH1P19 gene cytoplasm, ferric iron binding, ferrous iron binding, ferroxidase activity, intracellular sequestering of iron ion Taurus_UMD|evm.model.AC_000187.1.607 Q08DY6 E2F6_BOVIN 56.690 0.975779 1.01404 E2F6 - Transcription factor E2F6 - Bos taurus (Bovine) - E2F6 gene Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains (By similarity). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (By similarity). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (By similarity). Taurus_UMD|evm.model.AC_000187.1.608 Q28247 CO4A5_CANLF 93.436 0.998814 0.997043 COL4A5 - Collagen alpha-5(IV) chain precursor - Canis lupus familiaris (Dog) - COL4A5 gene Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Taurus_UMD|evm.model.AC_000187.1.609 O14654 IRS4_HUMAN 89.047 0.39172 0.999204 IRS4 - Insulin receptor substrate 4 - Homo sapiens (Human) - IRS4 gene Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. Taurus_UMD|evm.model.AC_000187.1.610 P62902 RL31_RAT 86.400 0.984 1 Rpl31 - 60S ribosomal protein L31 - Rattus norvegicus (Rat) - Rpl31 gene cytosolic large ribosomal subunit, nucleolus, nucleoplasm, polysomal ribosome, synapse, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000187.1.611 P70696 H2B1A_MOUSE 49.565 0.571429 1.54331 H2bc1 - Histone H2B type 1-A - Mus musculus (Mouse) - H2bc1 gene Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (PubMed:23884607, PubMed:28366643). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (PubMed:23884607). In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) (PubMed:28366643). Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (PubMed:23884607). Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000187.1.612 O02740 GUC2F_BOVIN 99.725 0.99817 0.990934 GUCY2F - Retinal guanylyl cyclase 2 precursor - Bos taurus (Bovine) - GUCY2F gene Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (PubMed:9571173, PubMed:9175772). Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:9571173, PubMed:9175772). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity). Taurus_UMD|evm.model.AC_000187.1.613 A6QNX3 NXT2_BOVIN 100.000 0.986014 1.00704 NXT2 - NTF2-related export protein 2 - Bos taurus (Bovine) - NXT2 gene Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export (By similarity). Taurus_UMD|evm.model.AC_000187.1.614 Q9UJ90 KCNE5_HUMAN 87.586 0.986301 1.02817 KCNE5 - Potassium voltage-gated channel subfamily E regulatory beta subunit 5 - Homo sapiens (Human) - KCNE5 gene Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. Taurus_UMD|evm.model.AC_000187.1.615 O60488 ACSL4_HUMAN 96.062 0.997191 1.00141 ACSL4 - Long-chain-fatty-acid--CoA ligase 4 - Homo sapiens (Human) - ACSL4 gene Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590). Taurus_UMD|evm.model.AC_000187.1.616 O46414 FRIH_BOVIN 81.215 0.986928 0.845304 FTH1 - Ferritin heavy chain - Bos taurus (Bovine) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000187.1.618 Q5JUK9 PAGE3_HUMAN 53.333 0.717742 1.09735 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Taurus_UMD|evm.model.AC_000187.1.619 Q5U3C3 TM164_HUMAN 97.980 0.993289 1.00337 TMEM164 - Transmembrane protein 164 - Homo sapiens (Human) - TMEM164 gene Taurus_UMD|evm.model.AC_000187.1.621 Q5RAS7 AMMR1_PONAB 97.690 0.95873 0.945946 AMMECR1 - AMME syndrome candidate gene 1 protein homolog - Pongo abelii (Sumatran orangutan) - AMMECR1 gene nucleus Taurus_UMD|evm.model.AC_000187.1.622 Q8NET4 RTL9_HUMAN 67.655 0.995646 0.992795 RTL9 - Retrotransposon Gag-like protein 9 - Homo sapiens (Human) - RTL9 gene Taurus_UMD|evm.model.AC_000187.1.623 P0C1H6 H2BFM_HUMAN 43.448 0.856287 1.08442 H2BW2 - Histone H2B type F-M - Homo sapiens (Human) - H2BW2 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000187.1.624 Q9BU40 CRDL1_HUMAN 95.671 0.99568 1.01535 CHRDL1 - Chordin-like protein 1 precursor - Homo sapiens (Human) - CHRDL1 gene Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. Taurus_UMD|evm.model.AC_000187.1.626 Q5JX71 F209A_HUMAN 38.562 0.828729 1.05848 FAM209A - Protein FAM209A precursor - Homo sapiens (Human) - FAM209A gene extracellular exosome, nucleus Taurus_UMD|evm.model.AC_000187.1.627 Q5JX71 F209A_HUMAN 40.458 0.876712 0.853801 FAM209A - Protein FAM209A precursor - Homo sapiens (Human) - FAM209A gene extracellular exosome, nucleus Taurus_UMD|evm.model.AC_000187.1.628 Q62829 PAK3_RAT 99.081 0.99633 1.00184 Pak3 - Serine/threonine-protein kinase PAK 3 - Rattus norvegicus (Rat) - Pak3 gene Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development (PubMed:12890786). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Taurus_UMD|evm.model.AC_000187.1.629 Q9Y6Q1 CAN6_HUMAN 94.228 0.996885 1.00156 CAPN6 - Calpain-6 - Homo sapiens (Human) - CAPN6 gene Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity). Taurus_UMD|evm.model.AC_000187.1.631 O43602 DCX_HUMAN 98.082 0.99446 0.989041 DCX - Neuronal migration protein doublecortin - Homo sapiens (Human) - DCX gene Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. Taurus_UMD|evm.model.AC_000187.1.632 P52301 RAN_XENLA 87.755 0.655405 0.685185 ran - GTP-binding nuclear protein Ran - Xenopus laevis (African clawed frog) - ran gene GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:8413630). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446). Required for normal progress through mitosis (By similarity). In concert with nemp1a/b, required for proper eye development (PubMed:25946333). Taurus_UMD|evm.model.AC_000187.1.633 Q5I0K7 ALG13_RAT 85.455 0.987952 1.00606 Alg13 - UDP-N-acetylglucosamine transferase subunit ALG13 homolog - Rattus norvegicus (Rat) - Alg13 gene May be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway. Taurus_UMD|evm.model.AC_000187.1.634 Q9NP73 ALG13_HUMAN 84.418 0.997809 0.80299 ALG13 - Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 - Homo sapiens (Human) - ALG13 gene Possible multifunctional enzyme with both glycosyltransferase and deubiquitinase activities. Taurus_UMD|evm.model.AC_000187.1.635 O62852 TRPC5_RABIT 95.938 0.99681 0.643737 TRPC5 - Short transient receptor potential channel 5 - Oryctolagus cuniculus (Rabbit) - TRPC5 gene Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion (By similarity). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity). Taurus_UMD|evm.model.AC_000187.1.636 A6NMA1 TR5OS_HUMAN 61.111 0.954955 1 TRPC5OS - Putative uncharacterized protein TRPC5OS - Homo sapiens (Human) - TRPC5OS gene Taurus_UMD|evm.model.AC_000187.1.637 Q9UL62 TRPC5_HUMAN 99.668 0.946372 0.325797 TRPC5 - Short transient receptor potential channel 5 - Homo sapiens (Human) - TRPC5 gene Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity). Taurus_UMD|evm.model.AC_000187.1.639 Q6ZR62 RTL4_HUMAN 66.467 0.988095 0.541935 RTL4 - Retrotransposon Gag-like protein 4 - Homo sapiens (Human) - RTL4 gene Involved in cognitive function in the brain, possibly via the noradrenergic system. Taurus_UMD|evm.model.AC_000187.1.640 Q6ZR62 RTL4_HUMAN 52.976 0.987013 0.496774 RTL4 - Retrotransposon Gag-like protein 4 - Homo sapiens (Human) - RTL4 gene Involved in cognitive function in the brain, possibly via the noradrenergic system. Taurus_UMD|evm.model.AC_000187.1.641 P39877 PA2G5_HUMAN 58.462 0.294931 1.57246 PLA2G5 - Phospholipase A2 group V precursor - Homo sapiens (Human) - PLA2G5 gene Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:8300559). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups (PubMed:8300559, PubMed:14998370, PubMed:23533611). Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (By similarity). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes (PubMed:23533611). Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines (PubMed:25725101). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (By similarity). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells (PubMed:12124392, PubMed:12796497). In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way (PubMed:12796497). In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A (PubMed:12124392). Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis (By similarity). May regulate antigen processing in antigen-presenting cells (By similarity). In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (PubMed:14998370). Taurus_UMD|evm.model.AC_000187.1.642 P19858 LDHA_BOVIN 99.699 0.993994 1.00301 LDHA - L-lactate dehydrogenase A chain - Bos taurus (Bovine) - LDHA gene L-lactate dehydrogenase activity Taurus_UMD|evm.model.AC_000187.1.643 A3FKF7 G3P_MUSPF 58.602 0.762626 0.594595 GAPDH - Glyceraldehyde-3-phosphate dehydrogenase - Mustela putorius furo (European domestic ferret) - GAPDH gene Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). Taurus_UMD|evm.model.AC_000187.1.646 Q60F97 5HT2C_CANLF 92.405 0.993671 0.689956 HTR2C - 5-hydroxytryptamine receptor 2C precursor - Canis lupus familiaris (Dog) - HTR2C gene G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis (By similarity). Taurus_UMD|evm.model.AC_000187.1.647 Q9Y388 RBMX2_HUMAN 77.509 0.870091 1.02795 RBMX2 - RNA-binding motif protein, X-linked 2 - Homo sapiens (Human) - RBMX2 gene Involved in pre-mRNA splicing as component of the activated spliceosome. Taurus_UMD|evm.model.AC_000187.1.648 Q5CZC0 FSIP2_HUMAN 55.122 0.304933 0.0968583 FSIP2 - Fibrous sheath-interacting protein 2 - Homo sapiens (Human) - FSIP2 gene Plays a role in spermatogenesis. Taurus_UMD|evm.model.AC_000187.1.649 Q5CZC0 FSIP2_HUMAN 55.959 0.969543 0.0285218 FSIP2 - Fibrous sheath-interacting protein 2 - Homo sapiens (Human) - FSIP2 gene Plays a role in spermatogenesis. Taurus_UMD|evm.model.AC_000187.1.650 Q6ZR62 RTL4_HUMAN 52.976 0.987013 0.496774 RTL4 - Retrotransposon Gag-like protein 4 - Homo sapiens (Human) - RTL4 gene Involved in cognitive function in the brain, possibly via the noradrenergic system. Taurus_UMD|evm.model.AC_000187.1.651 Q6ZR62 RTL4_HUMAN 51.205 0.847458 0.570968 RTL4 - Retrotransposon Gag-like protein 4 - Homo sapiens (Human) - RTL4 gene Involved in cognitive function in the brain, possibly via the noradrenergic system. Taurus_UMD|evm.model.AC_000187.1.652 Q86WI0 LHPL1_HUMAN 96.818 0.897541 1.10909 LHFPL1 - LHFPL tetraspan subfamily member 1 protein precursor - Homo sapiens (Human) - LHFPL1 gene membrane Taurus_UMD|evm.model.AC_000187.1.653 Q4VCS5 AMOT_HUMAN 95.810 0.810185 0.99631 AMOT - Angiomotin - Homo sapiens (Human) - AMOT gene Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Taurus_UMD|evm.model.AC_000187.1.654 P48763 SL9A2_RAT 70.205 0.491468 0.720787 Slc9a2 - Sodium/hydrogen exchanger 2 - Rattus norvegicus (Rat) - Slc9a2 gene Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption. Taurus_UMD|evm.model.AC_000187.1.655 O43829 ZBT14_HUMAN 71.667 0.90404 0.44098 ZBTB14 - Zinc finger and BTB domain-containing protein 14 - Homo sapiens (Human) - ZBTB14 gene Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters. Taurus_UMD|evm.model.AC_000187.1.657 Q9UK32 KS6A6_HUMAN 96.523 0.8187 1.17718 RPS6KA6 - Ribosomal protein S6 kinase alpha-6 - Homo sapiens (Human) - RPS6KA6 gene Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. Taurus_UMD|evm.model.AC_000187.1.658 F1MNN4 FBXW7_BOVIN 82.955 0.981343 0.379603 FBXW7 - F-box/WD repeat-containing protein 7 - Bos taurus (Bovine) - FBXW7 gene Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (By similarity). Taurus_UMD|evm.model.AC_000187.1.659 P35662 CYLC1_BOVIN 100.000 0.996979 0.992504 CYLC1 - Cylicin-1 - Bos taurus (Bovine) - CYLC1 gene Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. Taurus_UMD|evm.model.AC_000187.1.660 Q9HAI6 TASL_HUMAN 36.508 0.58804 1 TASL - TLR adapter interacting with SLC15A4 on the lysosome - Homo sapiens (Human) - TASL gene Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:32433612). Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons (PubMed:32433612). Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes (PubMed:31001245). Taurus_UMD|evm.model.AC_000187.1.661 Q58DU7 SH3L1_BOVIN 100.000 0.982609 1.00877 SH3BGRL - SH3 domain-binding glutamic acid-rich-like protein - Bos taurus (Bovine) - SH3BGRL gene Taurus_UMD|evm.model.AC_000187.1.662 Q9JL35 HMGN5_MOUSE 62.205 0.416667 0.738916 Hmgn5 - High mobility group nucleosome-binding domain-containing protein 5 - Mus musculus (Mouse) - Hmgn5 gene Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. Taurus_UMD|evm.model.AC_000187.1.663 Q6RI45 BRWD3_HUMAN 96.060 0.99889 1 BRWD3 - Bromodomain and WD repeat-containing protein 3 - Homo sapiens (Human) - BRWD3 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Taurus_UMD|evm.model.AC_000187.1.665 Q3UMG5 LRCH2_MOUSE 94.279 0.661716 0.783959 Lrch2 - Leucine-rich repeat and calponin homology domain-containing protein 2 - Mus musculus (Mouse) - Lrch2 gene May play a role in the organization of the cytoskeleton. Taurus_UMD|evm.model.AC_000187.1.666 Q6AYE4 VATC2_RAT 63.171 0.99375 0.752941 Atp6v1c2 - V-type proton ATPase subunit C 2 - Rattus norvegicus (Rat) - Atp6v1c2 gene Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Taurus_UMD|evm.model.AC_000187.1.667 A7E3Q8 PLST_BOVIN 100.000 0.99683 1.00159 PLS3 - Plastin-3 - Bos taurus (Bovine) - PLS3 gene Actin-bundling protein. Taurus_UMD|evm.model.AC_000187.1.668 Q5JX69 F209B_HUMAN 40.000 0.95 0.935673 FAM209B - Protein FAM209B precursor - Homo sapiens (Human) - FAM209B gene nucleus Taurus_UMD|evm.model.AC_000187.1.670 P08548 LIN1_NYCCO 28.889 0.960227 0.139683 LINE-1 reverse transcriptase homolog - Nycticebus coucang (Slow loris) Taurus_UMD|evm.model.AC_000187.1.671 Q9NUJ7 PLCX1_HUMAN 58.915 0.876712 0.452012 PLCXD1 - PI-PLC X domain-containing protein 1 - Homo sapiens (Human) - PLCXD1 gene Taurus_UMD|evm.model.AC_000187.1.674 O19110 TSPY1_BOVIN 50.000 0.550633 0.498423 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.AC_000187.1.675 Q9CRB3 HIUH_MOUSE 67.442 0.211055 1.68644 Urah - 5-hydroxyisourate hydrolase - Mus musculus (Mouse) - Urah gene Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). Taurus_UMD|evm.model.AC_000187.1.676 Q5VUJ6 LRCH2_HUMAN 99.237 0.984848 0.172549 LRCH2 - Leucine-rich repeat and calponin homology domain-containing protein 2 - Homo sapiens (Human) - LRCH2 gene May play a role in the organization of the cytoskeleton. Taurus_UMD|evm.model.AC_000187.1.677 Q96NX9 DACH2_HUMAN 91.765 0.555921 0.507513 DACH2 - Dachshund homolog 2 - Homo sapiens (Human) - DACH2 gene Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain. Taurus_UMD|evm.model.AC_000187.1.678 Q925Q8 DACH2_MOUSE 98.246 0.982456 0.0899054 Dach2 - Dachshund homolog 2 - Mus musculus (Mouse) - Dach2 gene Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression. Probably binds to DNA via its DACHbox-N domain. Taurus_UMD|evm.model.AC_000187.1.679 Q03274 PO22_POPJA 32.174 0.37013 0.433193 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 - Popillia japonica (Japanese beetle) Taurus_UMD|evm.model.AC_000187.1.680 P49335 PO3F4_HUMAN 96.143 0.994505 1.00831 POU3F4 - POU domain, class 3, transcription factor 4 - Homo sapiens (Human) - POU3F4 gene Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain. Taurus_UMD|evm.model.AC_000187.1.682 Q9UQ26 RIMS2_HUMAN 91.228 0.982143 0.0793763 RIMS2 - Regulating synaptic membrane exocytosis protein 2 - Homo sapiens (Human) - RIMS2 gene Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). Taurus_UMD|evm.model.AC_000187.1.684 P24386 RAE1_HUMAN 88.050 0.99686 0.975498 CHM - Rab proteins geranylgeranyltransferase component A 1 - Homo sapiens (Human) - CHM gene Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. Taurus_UMD|evm.model.AC_000187.1.685 O46415 FRIL_BOVIN 87.013 0.844444 0.514286 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000187.1.687 Q8VH49 HIG1A_RAT 86.022 0.978723 1.01075 Higd1a - HIG1 domain family member 1A, mitochondrial - Rattus norvegicus (Rat) - Higd1a gene Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). Taurus_UMD|evm.model.AC_000187.1.688 Q10126 YSM6_CAEEL 27.011 0.321357 1.7957 F52C9.6 - Putative uncharacterized transposon-derived protein F52C9.6 - Caenorhabditis elegans - F52C9.6 gene Taurus_UMD|evm.model.AC_000187.1.689 O02751 CFDP2_BOVIN 76.852 0.946903 0.190878 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.AC_000187.1.690 Q8WVV4 POF1B_HUMAN 86.420 0.816327 0.166384 POF1B - Protein POF1B - Homo sapiens (Human) - POF1B gene Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. Taurus_UMD|evm.model.AC_000187.1.691 Q8K4L4 POF1B_MOUSE 75.758 0.989583 0.327087 Pof1b - Protein POF1B - Mus musculus (Mouse) - Pof1b gene Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development (By similarity). Taurus_UMD|evm.model.AC_000187.1.692 Q9Y462 ZN711_HUMAN 97.635 0.997375 1.00131 ZNF711 - Zinc finger protein 711 - Homo sapiens (Human) - ZNF711 gene Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C. Taurus_UMD|evm.model.AC_000187.1.693 Q9JHW6 SAT1_CRIGR 61.404 0.561462 1.76023 SAT1 - Diamine acetyltransferase 1 - Cricetulus griseus (Chinese hamster) - SAT1 gene Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine. Taurus_UMD|evm.model.AC_000187.1.694 Q3SZ27 MIC27_BOVIN 100.000 0.992453 1.00379 APOL - MICOS complex subunit MIC27 precursor - Bos taurus (Bovine) - APOL gene Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. Taurus_UMD|evm.model.AC_000187.1.697 Q8BMA3 CNKR3_MOUSE 32.609 0.6 0.27027 Cnksr3 - Connector enhancer of kinase suppressor of ras 3 - Mus musculus (Mouse) - Cnksr3 gene Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC). Taurus_UMD|evm.model.AC_000187.1.698 Q8NEK8 TET5D_HUMAN 80.977 0.992327 1.00514 TENT5D - Terminal nucleotidyltransferase 5D - Homo sapiens (Human) - TENT5D gene Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase. Taurus_UMD|evm.model.AC_000187.1.699 Q92766 RREB1_HUMAN 37.175 0.6609 0.17131 RREB1 - Ras-responsive element-binding protein 1 - Homo sapiens (Human) - RREB1 gene Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:9305772, PubMed:15067362, PubMed:8816445, PubMed:10390538, PubMed:17550981). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). Taurus_UMD|evm.model.AC_000187.1.700 Q8NI27 THOC2_HUMAN 85.276 0.818182 0.124294 THOC2 - THO complex subunit 2 - Homo sapiens (Human) - THOC2 gene Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development. Taurus_UMD|evm.model.AC_000187.1.702 Q9Y458 TBX22_HUMAN 80.077 0.996109 0.988462 TBX22 - T-box transcription factor TBX22 - Homo sapiens (Human) - TBX22 gene Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis. Taurus_UMD|evm.model.AC_000187.1.703 Q7Z353 HDX_HUMAN 88.219 0.983784 0.536232 HDX - Highly divergent homeobox - Homo sapiens (Human) - HDX gene chromatin, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000187.1.704 Q3SYR7 RL9_BOVIN 97.917 0.989637 1.00521 RPL9 - 60S ribosomal protein L9 - Bos taurus (Bovine) - RPL9 gene cytosolic large ribosomal subunit, structural constituent of ribosome, cytoplasmic translation Taurus_UMD|evm.model.AC_000187.1.705 Q9BXC1 GP174_HUMAN 89.790 0.994012 1.003 GPR174 - Probable G-protein coupled receptor 174 - Homo sapiens (Human) - GPR174 gene Putative receptor for purines coupled to G-proteins. Taurus_UMD|evm.model.AC_000187.1.706 Q9P2Y5 UVRAG_HUMAN 88.182 0.43254 0.360515 UVRAG - UV radiation resistance-associated gene protein - Homo sapiens (Human) - UVRAG gene Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). Taurus_UMD|evm.model.AC_000187.1.707 O00398 P2Y10_HUMAN 89.634 0.993921 0.970501 P2RY10 - Putative P2Y purinoceptor 10 - Homo sapiens (Human) - P2RY10 gene Putative receptor for purines coupled to G-proteins. Taurus_UMD|evm.model.AC_000187.1.708 Q8BLG2 LPAR4_MOUSE 98.378 0.994609 1.0027 Lpar4 - Lysophosphatidic acid receptor 4 - Mus musculus (Mouse) - Lpar4 gene Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA (By similarity). Taurus_UMD|evm.model.AC_000187.1.710 Q7TN75 PEG10_MOUSE 41.111 0.463542 0.200418 Peg10 - Retrotransposon-derived protein PEG10 - Mus musculus (Mouse) - Peg10 gene May have a role in cell growth promotion, apoptotic resistance and hepatoma formation (By similarity). Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ACVRL1 (By similarity). When overexpressed, induces the formation of cellular extension, such as filipodia in association with ACVRL1 (By similarity). Involved at the immediate early stage of adipocyte differentiation (PubMed:17707377). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (PubMed:9473521). Taurus_UMD|evm.model.AC_000187.1.711 Q3KNM2 MARH5_MOUSE 97.701 0.988571 0.629496 Marchf5 - E3 ubiquitin-protein ligase MARCHF5 - Mus musculus (Mouse) - Marchf5 gene Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. Taurus_UMD|evm.model.AC_000187.1.712 Q0P594 PP2AB_BOVIN 89.968 0.993007 0.925566 PPP2CB - Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform - Bos taurus (Bovine) - PPP2CB gene PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Taurus_UMD|evm.model.AC_000187.1.713 Q6DFV6 FN3C1_MOUSE 57.376 0.997059 1.00295 Fndc3c1 - Fibronectin type III domain containing protein 3C1 - Mus musculus (Mouse) - Fndc3c1 gene Taurus_UMD|evm.model.AC_000187.1.714 Q5R7P7 TAF9B_PONAB 95.219 0.992063 1.00398 TAF9B - Transcription initiation factor TFIID subunit 9B - Pongo abelii (Sumatran orangutan) - TAF9B gene Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity). Taurus_UMD|evm.model.AC_000187.1.715 Q3T0P6 PGK1_BOVIN 100.000 0.995215 1.0024 PGK1 - Phosphoglycerate kinase 1 - Bos taurus (Bovine) - PGK1 gene Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. Taurus_UMD|evm.model.AC_000187.1.716 Q6R5N8 TLR13_MOUSE 78.363 0.944444 0.181635 Tlr13 - Toll-like receptor 13 precursor - Mus musculus (Mouse) - Tlr13 gene Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences. Taurus_UMD|evm.model.AC_000187.1.717 Q04656 ATP7A_HUMAN 92.600 0.998668 1.00067 ATP7A - Copper-transporting ATPase 1 - Homo sapiens (Human) - ATP7A gene ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:31283225, PubMed:28389643). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:28389643, PubMed:11092760). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (PubMed:28389643) (By similarity). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). Taurus_UMD|evm.model.AC_000187.1.718 Q5E954 DNJA1_BOVIN 99.748 0.994975 1.00252 DNAJA1 - DnaJ homolog subfamily A member 1 precursor - Bos taurus (Bovine) - DNAJA1 gene Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Taurus_UMD|evm.model.AC_000187.1.719 Q3SWU3 HNRDL_RAT 97.059 0.840796 0.624224 Hnrnpdl - Heterogeneous nuclear ribonucleoprotein D-like - Rattus norvegicus (Rat) - Hnrnpdl gene Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence (By similarity). Taurus_UMD|evm.model.AC_000187.1.720 Q9H0U3 MAGT1_HUMAN 100.000 0.993377 0.901493 MAGT1 - Magnesium transporter protein 1 precursor - Homo sapiens (Human) - MAGT1 gene Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Taurus_UMD|evm.model.AC_000187.1.721 Q7YQM4 ATRX_PANTR 89.735 0.999193 0.994783 ATRX - Transcriptional regulator ATRX - Pan troglodytes (Chimpanzee) - ATRX gene Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. May be involved in transcriptional regulation of telomeric repeat-containing RNA (TERRA). Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (By similarity). Taurus_UMD|evm.model.AC_000187.1.722 Q9ESL8 FGF16_MOUSE 99.517 0.990385 1.00483 Fgf16 - Fibroblast growth factor 16 - Mus musculus (Mouse) - Fgf16 gene Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. Taurus_UMD|evm.model.AC_000187.1.723 Q93079 H2B1H_HUMAN 88.571 0.945205 0.579365 H2BC9 - Histone H2B type 1-H - Homo sapiens (Human) - H2BC9 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000187.1.724 Q3ZCI6 F204A_BOVIN 86.000 0.924528 0.227468 FAM204A - Protein FAM204A - Bos taurus (Bovine) - FAM204A gene Taurus_UMD|evm.model.AC_000187.1.725 Q6RI85 PGK2_PIG 83.333 0.625 0.134293 PGK2 - Phosphoglycerate kinase 2 - Sus scrofa (Pig) - PGK2 gene Essential for sperm motility and male fertility but is not required for the completion of spermatogenesis. Taurus_UMD|evm.model.AC_000187.1.726 Q5RDE1 IF2P_PONAB 72.308 0.879195 0.366393 EIF5B - Eukaryotic translation initiation factor 5B - Pongo abelii (Sumatran orangutan) - EIF5B gene Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. Taurus_UMD|evm.model.AC_000187.1.727 O60841 IF2P_HUMAN 97.783 0.980392 0.37623 EIF5B - Eukaryotic translation initiation factor 5B - Homo sapiens (Human) - EIF5B gene Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. Taurus_UMD|evm.model.AC_000187.1.728 Q9D0B6 PBDC1_MOUSE 79.293 0.877273 1.11111 Pbdc1 - Protein PBDC1 - Mus musculus (Mouse) - Pbdc1 gene Taurus_UMD|evm.model.AC_000187.1.729 Q8TD90 MAGE2_HUMAN 86.973 0.994275 1.00191 MAGEE2 - Melanoma-associated antigen E2 - Homo sapiens (Human) - MAGEE2 gene Taurus_UMD|evm.model.AC_000187.1.730 Q96MV8 ZDH15_HUMAN 97.626 0.994083 1.00297 ZDHHC15 - Palmitoyltransferase ZDHHC15 - Homo sapiens (Human) - ZDHHC15 gene Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:18817523, PubMed:23034182). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex (PubMed:18817523). Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins (PubMed:18817523). In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis (By similarity). Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon (By similarity). Could also catalyze the palmitoylation of GAP43 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate FYN as shown in vitro (PubMed:19956733). Taurus_UMD|evm.model.AC_000187.1.731 Q32LA4 UPP_BOVIN 94.444 0.993127 0.95098 UPRT - Uracil phosphoribosyltransferase homolog - Bos taurus (Bovine) - UPRT gene Taurus_UMD|evm.model.AC_000187.1.732 P52293 IMA1_MOUSE 69.952 0.78373 0.952741 Kpna2 - Importin subunit alpha-1 - Mus musculus (Mouse) - Kpna2 gene Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Taurus_UMD|evm.model.AC_000187.1.733 O75027 ABCB7_HUMAN 93.484 0.997344 1.00133 ABCB7 - Iron-sulfur clusters transporter ABCB7, mitochondrial precursor - Homo sapiens (Human) - ABCB7 gene Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins, in turns participates in iron homeostasis (PubMed:33157103, PubMed:17192393, PubMed:10196363). Moreover through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (By similarity). Taurus_UMD|evm.model.AC_000187.1.735 Q5RDL6 EID1_PONAB 67.188 0.942149 0.643617 EID1 - EP300-interacting inhibitor of differentiation 1 - Pongo abelii (Sumatran orangutan) - EID1 gene Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms (By similarity). Taurus_UMD|evm.model.AC_000187.1.736 Q5QGS0 NEXMI_HUMAN 90.646 0.998653 0.979551 NEXMIF - Neurite extension and migration factor - Homo sapiens (Human) - NEXMIF gene Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1). Taurus_UMD|evm.model.AC_000187.1.737 Q9NVW2 RNF12_HUMAN 92.480 0.996732 0.980769 RLIM - E3 ubiquitin-protein ligase RLIM - Homo sapiens (Human) - RLIM gene E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. Taurus_UMD|evm.model.AC_000187.1.738 P36021 MOT8_HUMAN 91.837 0.882645 1.12245 SLC16A2 - Monocarboxylate transporter 8 - Homo sapiens (Human) - SLC16A2 gene Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr. Taurus_UMD|evm.model.AC_000187.1.739 O35274 NEB2_RAT 58.621 0.304813 0.228886 Ppp1r9b - Neurabin-2 - Rattus norvegicus (Rat) - Ppp1r9b gene Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1. Required for hepatocyte growth factor (HGF)-induced cell migration (By similarity). Taurus_UMD|evm.model.AC_000187.1.740 Q3T0Q6 CNBP_BOVIN 69.591 0.988372 1.01176 CNBP - Cellular nucleic acid-binding protein - Bos taurus (Bovine) - CNBP gene Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression (By similarity). Taurus_UMD|evm.model.AC_000187.1.742 P04394 NDUV2_BOVIN 98.684 0.986928 0.614458 NDUFV2 - NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor - Bos taurus (Bovine) - NDUFV2 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Taurus_UMD|evm.model.AC_000187.1.743 Q9ES28 ARHG7_MOUSE 79.762 0.131922 0.712297 Arhgef7 - Rho guanine nucleotide exchange factor 7 - Mus musculus (Mouse) - Arhgef7 gene Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). Taurus_UMD|evm.model.AC_000187.1.744 Q5VXU3 CHIC1_HUMAN 97.333 0.99115 1.00893 CHIC1 - Cysteine-rich hydrophobic domain-containing protein 1 - Homo sapiens (Human) - CHIC1 gene Taurus_UMD|evm.model.AC_000187.1.745 O14627 CDX4_HUMAN 83.871 0.992857 0.985915 CDX4 - Homeobox protein CDX-4 - Homo sapiens (Human) - CDX4 gene chromatin, nucleus, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, animal organ morphogenesis, anterior/posterior axis specification Taurus_UMD|evm.model.AC_000187.1.746 Q5HYR2 DMRTC_HUMAN 64.407 0.246809 1.22396 DMRTC1 - Doublesex- and mab-3-related transcription factor C1 - Homo sapiens (Human) - DMRTC1 gene chromatin, nucleus Taurus_UMD|evm.model.AC_000187.1.747 Q5JQF8 PAP1M_HUMAN 98.500 0.423404 2.35 PABPC1L2A - Polyadenylate-binding protein 1-like 2 - Homo sapiens (Human) - PABPC1L2A gene extracellular exosome Taurus_UMD|evm.model.AC_000187.1.748 Q5JQF8 PAP1M_HUMAN 99.000 0.99005 1.005 PABPC1L2A - Polyadenylate-binding protein 1-like 2 - Homo sapiens (Human) - PABPC1L2A gene extracellular exosome Taurus_UMD|evm.model.AC_000187.1.749 P62630 EF1A1_RAT 85.093 0.987654 0.350649 Eef1a1 - Elongation factor 1-alpha 1 - Rattus norvegicus (Rat) - Eef1a1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000187.1.750 P62630 EF1A1_RAT 66.390 0.984694 0.424242 Eef1a1 - Elongation factor 1-alpha 1 - Rattus norvegicus (Rat) - Eef1a1 gene This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Taurus_UMD|evm.model.AC_000187.1.751 P46020 KPB1_HUMAN 94.113 0.998348 0.990188 PHKA1 - Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform - Homo sapiens (Human) - PHKA1 gene Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. Taurus_UMD|evm.model.AC_000187.1.752 Q0VCB2 HDAC8_BOVIN 99.735 0.841163 1.18568 HDAC8 - Histone deacetylase 8 - Bos taurus (Bovine) - HDAC8 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility (By similarity). Taurus_UMD|evm.model.AC_000187.1.753 Q9BDI3 CITE1_BOVIN 100.000 0.754864 1.31795 CITED1 - Cbp/p300-interacting transactivator 1 - Bos taurus (Bovine) - CITED1 gene Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner (By similarity). Taurus_UMD|evm.model.AC_000187.1.754 P79103 RS4_BOVIN 100.000 0.992424 1.0038 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000187.1.755 A6QQR4 ERC6L_BOVIN 100.000 0.998391 1.00081 ERCC6L - DNA excision repair protein ERCC-6-like - Bos taurus (Bovine) - ERCC6L gene DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro). Taurus_UMD|evm.model.AC_000187.1.756 A6QPY8 PIN4_BOVIN 100.000 0.984848 1.00763 PIN4 - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 - Bos taurus (Bovine) - PIN4 gene Involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA (By similarity). Taurus_UMD|evm.model.AC_000187.1.757 Q5HYW2 NHSL2_HUMAN 86.287 0.953654 0.915918 NHSL2 - NHS-like protein 2 - Homo sapiens (Human) - NHSL2 gene cell differentiation Taurus_UMD|evm.model.AC_000187.1.758 Q5HYW3 RTL5_HUMAN 74.701 0.996522 1.01054 RTL5 - Retrotransposon Gag-like protein 5 - Homo sapiens (Human) - RTL5 gene Taurus_UMD|evm.model.AC_000187.1.759 Q5HYW2 NHSL2_HUMAN 95.522 0.437086 0.123265 NHSL2 - NHS-like protein 2 - Homo sapiens (Human) - NHSL2 gene cell differentiation Taurus_UMD|evm.model.AC_000187.1.760 A5PKC7 CX049_BOVIN 54.309 0.509685 1.54682 Uncharacterized protein CXorf49 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000187.1.761 P79103 RS4_BOVIN 94.915 0.988764 0.676806 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000187.1.762 A5PKC7 CX049_BOVIN 96.875 0.898305 0.331461 Uncharacterized protein CXorf49 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000187.1.763 A5PKC7 CX049_BOVIN 98.013 0.391645 0.717228 Uncharacterized protein CXorf49 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000187.1.764 A5PKC7 CX049_BOVIN 67.391 0.136778 0.616105 Uncharacterized protein CXorf49 homolog - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000187.1.765 P79103 RS4_BOVIN 95.327 0.204808 3.95437 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000187.1.766 P79103 RS4_BOVIN 88.213 0.992032 0.954373 RPS4 - 40S ribosomal protein S4 - Bos taurus (Bovine) - RPS4 gene cytosolic small ribosomal subunit, RNA binding, structural constituent of ribosome, translation Taurus_UMD|evm.model.AC_000187.1.767 Q6DCE8 CTR2_XENLA 68.478 0.21875 0.66881 slc7a2 - Cationic amino acid transporter 2 - Xenopus laevis (African clawed frog) - slc7a2 gene Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Taurus_UMD|evm.model.AC_000187.1.768 Q5MD61 CXCR3_BOVIN 100.000 0.883777 1.12842 CXCR3 - C-X-C chemokine receptor type 3 - Bos taurus (Bovine) - CXCR3 gene Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). Taurus_UMD|evm.model.AC_000187.1.769 Q96QF7 ACRC_HUMAN 59.394 0.631808 0.664255 GCNA - Acidic repeat-containing protein - Homo sapiens (Human) - GCNA gene nucleoplasm, nucleus Taurus_UMD|evm.model.AC_000187.1.770 P81436 OGT1_RABIT 99.904 0.99809 1.00096 OGT - UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit - Oryctolagus cuniculus (Rabbit) - OGT gene Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue (PubMed:2137449). Acts on cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Probably by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (By similarity). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues. O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex. Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver. Stabilizes clock proteins ARNTL/BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation. Promotes the CLOCK-ARNTL/BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2. O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (By similarity). Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (By similarity). Glycosylates HOXA1 (By similarity). O-glycosylates FNIP1 (By similarity). Taurus_UMD|evm.model.AC_000187.1.771 P21675 TAF1_HUMAN 95.238 0.998953 1.02083 TAF1 - Transcription initiation factor TFIID subunit 1 - Homo sapiens (Human) - TAF1 gene Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300). Taurus_UMD|evm.model.AC_000187.1.772 P08582 TRFM_HUMAN 95.082 0.840278 0.195122 MELTF - Melanotransferrin precursor - Homo sapiens (Human) - MELTF gene Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. Taurus_UMD|evm.model.AC_000187.1.773 P84096 RHOG_MOUSE 74.346 0.959596 1.03665 Rhog - Rho-related GTP-binding protein RhoG precursor - Mus musculus (Mouse) - Rhog gene Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (By similarity). Taurus_UMD|evm.model.AC_000187.1.774 Q9UKP3 ITBP2_HUMAN 93.040 0.951049 0.824207 ITGB1BP2 - Integrin beta-1-binding protein 2 - Homo sapiens (Human) - ITGB1BP2 gene May play a role during maturation and/or organization of muscles cells. Taurus_UMD|evm.model.AC_000187.1.775 Q5RFL9 NONO_PONAB 99.575 0.995754 1 NONO - Non-POU domain-containing octamer-binding protein - Pongo abelii (Sumatran orangutan) - NONO gene DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Taurus_UMD|evm.model.AC_000187.1.776 Q14202 ZMYM3_HUMAN 97.744 0.998545 1.00365 ZMYM3 - Zinc finger MYM-type protein 3 - Homo sapiens (Human) - ZMYM3 gene Plays a role in the regulation of cell morphology and cytoskeletal organization. Taurus_UMD|evm.model.AC_000187.1.777 O18968 CXB1_BOVIN 100.000 0.992982 1.00352 GJB1 - Gap junction beta-1 protein - Bos taurus (Bovine) - GJB1 gene One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Taurus_UMD|evm.model.AC_000187.1.778 Q5E9J1 HNRPF_BOVIN 90.610 0.99061 0.514493 HNRNPF - Heterogeneous nuclear ribonucleoprotein F - Bos taurus (Bovine) - HNRNPF gene Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity). Taurus_UMD|evm.model.AC_000187.1.779 Q9NZ94 NLGN3_HUMAN 99.410 0.997644 1.00118 NLGN3 - Neuroligin-3 precursor - Homo sapiens (Human) - NLGN3 gene Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity). Taurus_UMD|evm.model.AC_000187.1.780 Q5RCU2 MED12_PONPY 97.617 0.999081 0.998166 MED12 - Mediator of RNA polymerase II transcription subunit 12 - Pongo pygmaeus (Bornean orangutan) - MED12 gene Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathways (By similarity). Taurus_UMD|evm.model.AC_000187.1.781 Q95118 IL2RG_BOVIN 100.000 0.687732 1.41953 IL2RG - Cytokine receptor common subunit gamma precursor - Bos taurus (Bovine) - IL2RG gene Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity). Taurus_UMD|evm.model.AC_000187.1.782 P98177 FOXO4_HUMAN 87.891 0.996101 1.01584 FOXO4 - Forkhead box protein O4 - Homo sapiens (Human) - FOXO4 gene Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Taurus_UMD|evm.model.AC_000187.1.783 Q9UMY4 SNX12_HUMAN 100.000 0.98773 1.00617 SNX12 - Sorting nexin-12 - Homo sapiens (Human) - SNX12 gene May be involved in several stages of intracellular trafficking. Taurus_UMD|evm.model.AC_000187.1.784 P49666 RL21_PIG 89.375 0.987578 1.00625 RPL21 - 60S ribosomal protein L21 - Sus scrofa (Pig) - RPL21 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000187.1.785 Q8WY07 CTR3_HUMAN 88.548 0.996774 1.00162 SLC7A3 - Cationic amino acid transporter 3 - Homo sapiens (Human) - SLC7A3 gene Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Taurus_UMD|evm.model.AC_000187.1.786 Q8IYF3 TEX11_HUMAN 64.874 0.990207 0.97766 TEX11 - Testis-expressed protein 11 - Homo sapiens (Human) - TEX11 gene Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers. Taurus_UMD|evm.model.AC_000187.1.787 Q92796 DLG3_HUMAN 94.346 0.997647 1.04039 DLG3 - Disks large homolog 3 - Homo sapiens (Human) - DLG3 gene Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Taurus_UMD|evm.model.AC_000187.1.788 Q9HCC8 GDPD2_HUMAN 82.375 0.996296 1.00186 GDPD2 - Glycerophosphoinositol inositolphosphodiesterase GDPD2 - Homo sapiens (Human) - GDPD2 gene Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4-phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton (By similarity). Taurus_UMD|evm.model.AC_000187.1.789 O95239 KIF4A_HUMAN 96.476 0.194492 0.943182 KIF4A - Chromosome-associated kinesin KIF4A - Homo sapiens (Human) - KIF4A gene Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). Taurus_UMD|evm.model.AC_000187.1.790 Q6QA76 PDZ11_PIG 95.890 0.895062 1.15714 PDZD11 - PDZ domain-containing protein 11 - Sus scrofa (Pig) - PDZD11 gene Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33. Taurus_UMD|evm.model.AC_000187.1.791 Q9N0H5 ARRC_BOVIN 98.201 0.987277 1.01028 ARR3 - Arrestin-C - Bos taurus (Bovine) - ARR3 gene May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins. Taurus_UMD|evm.model.AC_000187.1.792 P58826 P2RY4_CRIGR 90.909 0.448087 2.21818 P2RY4 - P2Y purinoceptor 4 - Cricetulus griseus (Chinese hamster) - P2RY4 gene Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Taurus_UMD|evm.model.AC_000187.1.793 Q58HT5 AWAT1_HUMAN 75.248 0.906907 1.01524 AWAT1 - Acyl-CoA wax alcohol acyltransferase 1 - Homo sapiens (Human) - AWAT1 gene Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15671038). Shows a strong preference for decyl alcohol (C10), with less activity towards C16 and C18 alcohols (PubMed:15671038). Shows a strong preference for saturated acyl-CoAs (PubMed:15671038). Taurus_UMD|evm.model.AC_000187.1.794 A6QP72 DG2L6_BOVIN 100.000 0.988235 1.0089 DGAT2L6 - Diacylglycerol O-acyltransferase 2-like protein 6 - Bos taurus (Bovine) - DGAT2L6 gene Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity to produce wax esters. Taurus_UMD|evm.model.AC_000187.1.795 P78318 IGBP1_HUMAN 82.544 0.988201 1 IGBP1 - Immunoglobulin-binding protein 1 - Homo sapiens (Human) - IGBP1 gene Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits. Taurus_UMD|evm.model.AC_000187.1.796 Q6IE21 OTU6A_MOUSE 67.123 0.993151 1.0069 Otud6a - OTU domain-containing protein 6A - Mus musculus (Mouse) - Otud6a gene Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains (By similarity). Taurus_UMD|evm.model.AC_000187.1.797 Q6E1M8 AWAT2_MOUSE 80.120 0.991018 1.003 Awat2 - Acyl-CoA wax alcohol acyltransferase 2 - Mus musculus (Mouse) - Awat2 gene Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15220349). Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donor and acceptor, respectively (PubMed:15220349). Also possesses acyl-CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis-specific retinyl ester synthesis (PubMed:28096191). Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13- cis-retinol and all-trans-retinol substrates (By similarity). Taurus_UMD|evm.model.AC_000187.1.798 Q9BEG5 EDA_BOVIN 94.771 0.77551 0.501279 EDA - Ectodysplasin-A - Bos taurus (Bovine) - EDA gene Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Taurus_UMD|evm.model.AC_000187.1.799 P62752 RL23A_RAT 100.000 0.974843 1.01923 Rpl23a - 60S ribosomal protein L23a - Rattus norvegicus (Rat) - Rpl23a gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity). Taurus_UMD|evm.model.AC_000187.1.800 Q9BEG5 EDA_BOVIN 99.248 0.977778 0.345269 EDA - Ectodysplasin-A - Bos taurus (Bovine) - EDA gene Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Taurus_UMD|evm.model.AC_000187.1.801 O75949 F155B_HUMAN 91.350 0.995781 1.00424 FAM155B - Transmembrane protein FAM155B - Homo sapiens (Human) - FAM155B gene plasma membrane, calcium ion import across plasma membrane Taurus_UMD|evm.model.AC_000187.1.802 P24049 RL17_RAT 91.667 0.967213 0.331522 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000187.1.803 Q5JUK9 PAGE3_HUMAN 51.579 0.783333 1.06195 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Taurus_UMD|evm.model.AC_000187.1.804 Q8NG27 PJA1_HUMAN 83.858 0.916364 0.427683 PJA1 - E3 ubiquitin-protein ligase Praja-1 - Homo sapiens (Human) - PJA1 gene Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting. Taurus_UMD|evm.model.AC_000187.1.805 P98172 EFNB1_HUMAN 96.243 0.994236 1.00289 EFNB1 - Ephrin-B1 precursor - Homo sapiens (Human) - EFNB1 gene Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:8070404, PubMed:7973638). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:8070404, PubMed:7973638). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). Taurus_UMD|evm.model.AC_000187.1.806 Q92502 STAR8_HUMAN 88.136 0.551331 1.02835 STARD8 - StAR-related lipid transfer protein 8 - Homo sapiens (Human) - STARD8 gene Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1. Taurus_UMD|evm.model.AC_000187.1.808 A6QLC6 YIPF6_BOVIN 100.000 0.991561 1.00424 YIPF6 - Protein YIPF6 - Bos taurus (Bovine) - YIPF6 gene May be required for stable YIPF1 and YIPF2 protein expression. Taurus_UMD|evm.model.AC_000187.1.809 Q7YQL5 OPHN1_PONPY 98.077 0.6375 0.0997506 OPHN1 - Oligophrenin-1 - Pongo pygmaeus (Bornean orangutan) - OPHN1 gene Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre-synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). Taurus_UMD|evm.model.AC_000187.1.810 Q7YQL5 OPHN1_PONPY 86.298 0.997308 0.926434 OPHN1 - Oligophrenin-1 - Pongo pygmaeus (Bornean orangutan) - OPHN1 gene Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre-synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). Taurus_UMD|evm.model.AC_000187.1.811 Q9GKL7 ANDR_PIG 93.875 0.997755 0.99442 AR - Androgen receptor - Sus scrofa (Pig) - AR gene Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. Taurus_UMD|evm.model.AC_000187.1.813 Q9HAV5 TNR27_HUMAN 84.615 0.993333 1.0101 EDA2R - Tumor necrosis factor receptor superfamily member 27 - Homo sapiens (Human) - EDA2R gene Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. Taurus_UMD|evm.model.AC_000187.1.814 Q64336 TBR1_MOUSE 80.000 0.372093 0.189427 Tbr1 - T-box brain protein 1 - Mus musculus (Mouse) - Tbr1 gene Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:9883721, PubMed:11239428, PubMed:21285371). As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (PubMed:21285371). Taurus_UMD|evm.model.AC_000187.1.815 P21573 YBOX1_XENLA 46.835 0.530303 0.435644 ybx1 - Y-box-binding protein 1 - Xenopus laevis (African clawed frog) - ybx1 gene DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation (By similarity). Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (By similarity). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and preventing mRNA decay (By similarity). Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation (By similarity). Also promotes maternal-to-zygotic transition in oocytes and embryos by promoting translation repression; molecular mechanisms governing translation repression are unknown (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (By similarity). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (By similarity). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (By similarity). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (By similarity). Also able to bind DNA and regulate transcription (PubMed:2247479). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3') (PubMed:2247479). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (By similarity). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (By similarity). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (By similarity). Taurus_UMD|evm.model.AC_000187.1.816 Q920G9 GMCL1_MOUSE 56.000 0.984802 0.627863 Gmcl1 - Germ cell-less protein-like 1 - Mus musculus (Mouse) - Gmcl1 gene Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport. Taurus_UMD|evm.model.AC_000187.1.817 Q8IUQ4 SIAH1_HUMAN 76.761 0.992982 1.01064 SIAH1 - E3 ubiquitin-protein ligase SIAH1 - Homo sapiens (Human) - SIAH1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP (PubMed:10747903, PubMed:11146551, PubMed:11389839, PubMed:11389840, PubMed:11483517, PubMed:11483518, PubMed:11752454, PubMed:12072443). Confers constitutive instability to HIPK2 through proteasomal degradation (PubMed:18536714). It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Has some overlapping function with SIAH2 (PubMed:14506261, PubMed:14645235, PubMed:14654780, PubMed:15064394, PubMed:16085652, PubMed:19224863, PubMed:20508617, PubMed:22483617, PubMed:9334332, PubMed:9858595). Induces apoptosis in cooperation with PEG3 (By similarity). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus (By similarity). GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (By similarity). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Taurus_UMD|evm.model.AC_000187.1.819 Q9NS84 CHST7_HUMAN 91.975 0.995893 1.00206 CHST7 - Carbohydrate sulfotransferase 7 - Homo sapiens (Human) - CHST7 gene Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc. Taurus_UMD|evm.model.AC_000187.1.820 Q96T83 SL9A7_HUMAN 93.605 0.985175 1.02345 SLC9A7 - Sodium/hydrogen exchanger 7 - Homo sapiens (Human) - SLC9A7 gene Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to the regulation of Golgi apparatus volume and pH. Taurus_UMD|evm.model.AC_000187.1.821 Q08945 SSRP1_HUMAN 71.848 0.984456 0.816643 SSRP1 - FACT complex subunit SSRP1 - Homo sapiens (Human) - SSRP1 gene Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. Taurus_UMD|evm.model.AC_000187.1.822 Q58DW5 RL5_BOVIN 73.490 0.992126 0.855219 RPL5 - 60S ribosomal protein L5 - Bos taurus (Bovine) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B. Taurus_UMD|evm.model.AC_000187.1.823 O75695 XRP2_HUMAN 85.795 0.993976 0.948571 RP2 - Protein XRP2 - Homo sapiens (Human) - RP2 gene Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. Taurus_UMD|evm.model.AC_000187.1.825 Q92613 JADE3_HUMAN 83.961 0.997573 1.00122 JADE3 - Protein Jade-3 - Homo sapiens (Human) - JADE3 gene Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Taurus_UMD|evm.model.AC_000187.1.826 Q9TTJ5 RGN_BOVIN 100.000 0.737624 1.35117 RGN - Regucalcin - Bos taurus (Bovine) - RGN gene Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). Taurus_UMD|evm.model.AC_000187.1.827 Q8HXG5 NDUBB_BOVIN 100.000 0.987097 1.00649 NDUFB11 - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial precursor - Bos taurus (Bovine) - NDUFB11 gene Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Taurus_UMD|evm.model.AC_000187.1.828 P98175 RBM10_HUMAN 97.207 0.932731 1.07097 RBM10 - RNA-binding protein 10 - Homo sapiens (Human) - RBM10 gene May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). Taurus_UMD|evm.model.AC_000187.1.829 A3KMV5 UBA1_BOVIN 100.000 0.576522 1.72306 UBA1 - Ubiquitin-like modifier-activating enzyme 1 - Bos taurus (Bovine) - UBA1 gene Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. Taurus_UMD|evm.model.AC_000187.1.830 P51784 UBP11_HUMAN 82.701 0.975904 0.948079 USP11 - Ubiquitin carboxyl-terminal hydrolase 11 - Homo sapiens (Human) - USP11 gene Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Taurus_UMD|evm.model.AC_000187.1.831 Q2NL01 GPX8_BOVIN 47.500 0.375 0.497608 GPX8 - Probable glutathione peroxidase 8 - Bos taurus (Bovine) - GPX8 gene peroxidase activity Taurus_UMD|evm.model.AC_000187.1.832 P51786 ZN157_HUMAN 86.538 0.961995 0.832016 ZNF157 - Zinc finger protein 157 - Homo sapiens (Human) - ZNF157 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.833 P51814 ZNF41_HUMAN 79.340 0.996134 0.945189 ZNF41 - Zinc finger protein 41 - Homo sapiens (Human) - ZNF41 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.834 O19004 ARAF_PIG 92.824 0.996885 1.05941 ARAF - Serine/threonine-protein kinase A-Raf - Sus scrofa (Pig) - ARAF gene Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). Taurus_UMD|evm.model.AC_000187.1.835 P17599 SYN1_BOVIN 97.814 0.447174 0.576487 SYN1 - Synapsin-1 - Bos taurus (Bovine) - SYN1 gene Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). Taurus_UMD|evm.model.AC_000187.1.836 P20414 TIMP1_BOVIN 100.000 0.804688 1.23671 TIMP1 - Metalloproteinase inhibitor 1 precursor - Bos taurus (Bovine) - TIMP1 gene Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Taurus_UMD|evm.model.AC_000187.1.837 P51508 ZNF81_HUMAN 83.617 0.976153 0.951589 ZNF81 - Zinc finger protein 81 - Homo sapiens (Human) - ZNF81 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.838 P17599 SYN1_BOVIN 99.254 0.863636 0.21813 SYN1 - Synapsin-1 - Bos taurus (Bovine) - SYN1 gene Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). Taurus_UMD|evm.model.AC_000187.1.839 P51814 ZNF41_HUMAN 70.270 0.493151 0.088916 ZNF41 - Zinc finger protein 41 - Homo sapiens (Human) - ZNF41 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.840 Q9BSK4 FEM1A_HUMAN 60.927 0.545113 0.397608 FEM1A - Protein fem-1 homolog A - Homo sapiens (Human) - FEM1A gene Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4. Taurus_UMD|evm.model.AC_000187.1.841 Q5EA28 CXXC1_BOVIN 52.632 0.596838 0.384498 CXXC1 - CXXC-type zinc finger protein 1 - Bos taurus (Bovine) - CXXC1 gene Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. Taurus_UMD|evm.model.AC_000187.1.842 P17599 SYN1_BOVIN 100.000 0.984252 0.179887 SYN1 - Synapsin-1 - Bos taurus (Bovine) - SYN1 gene Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). Taurus_UMD|evm.model.AC_000187.1.843 P27918 PROP_HUMAN 74.887 0.948387 0.991471 CFP - Properdin precursor - Homo sapiens (Human) - CFP gene A positive regulator of the alternate pathway (AP) of complement (PubMed:20382442, PubMed:28264884). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (PubMed:20382442, PubMed:28264884). Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (PubMed:31507604). Taurus_UMD|evm.model.AC_000187.1.844 P19419 ELK1_HUMAN 88.182 0.995465 1.03037 ELK1 - ETS domain-containing protein Elk-1 - Homo sapiens (Human) - ELK1 gene Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity). Taurus_UMD|evm.model.AC_000187.1.845 Q32P97 UXT_BOVIN 100.000 0.987261 1.00641 UXT - Protein UXT - Bos taurus (Bovine) - UXT gene Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Taurus_UMD|evm.model.AC_000187.1.846 P35507 KC1B_BOVIN 90.476 0.994065 1.00298 CSNK1B - Casein kinase I isoform beta - Bos taurus (Bovine) - CSNK1B gene Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Taurus_UMD|evm.model.AC_000187.1.847 P35507 KC1B_BOVIN 100.000 0.994065 1.00298 CSNK1B - Casein kinase I isoform beta - Bos taurus (Bovine) - CSNK1B gene Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Taurus_UMD|evm.model.AC_000187.1.848 P51508 ZNF81_HUMAN 73.611 0.38587 0.278366 ZNF81 - Zinc finger protein 81 - Homo sapiens (Human) - ZNF81 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.849 Q9Y473 ZN175_HUMAN 69.697 0.385542 0.116737 ZNF175 - Zinc finger protein 175 - Homo sapiens (Human) - ZNF175 gene Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity. Taurus_UMD|evm.model.AC_000187.1.851 Q7RTT3 SSX9_HUMAN 42.857 0.378788 1.05319 SSX9P - Putative protein SSX9 - Homo sapiens (Human) - SSX9P gene Could act as a modulator of transcription. Taurus_UMD|evm.model.AC_000187.1.852 Q16384 SSX1_HUMAN 46.667 0.521429 0.744681 SSX1 - Protein SSX1 - Homo sapiens (Human) - SSX1 gene Could act as a modulator of transcription. Taurus_UMD|evm.model.AC_000187.1.853 Q1RML4 SPIC_BOVIN 96.396 0.982143 0.451613 SPIC - Transcription factor Spi-C - Bos taurus (Bovine) - SPIC gene Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity). Taurus_UMD|evm.model.AC_000187.1.854 Q5E9S9 S38A5_BOVIN 99.788 0.995763 0.987448 SLC38A5 - Sodium-coupled neutral amino acid transporter 5 - Bos taurus (Bovine) - SLC38A5 gene Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium (By similarity). Taurus_UMD|evm.model.AC_000187.1.855 Q9UET6 TRM7_HUMAN 91.159 0.990909 1.00304 FTSJ1 - Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase - Homo sapiens (Human) - FTSJ1 gene Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. Taurus_UMD|evm.model.AC_000187.1.856 Q9H237 PORCN_HUMAN 98.482 0.995671 1.00217 PORCN - Protein-serine O-palmitoleoyltransferase porcupine - Homo sapiens (Human) - PORCN gene Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors. Taurus_UMD|evm.model.AC_000187.1.857 Q15125 EBP_HUMAN 85.388 0.943723 1.00435 EBP - 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase - Homo sapiens (Human) - EBP gene Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. Taurus_UMD|evm.model.AC_000187.1.858 A1A5B6 TBC25_MOUSE 93.210 0.940407 0.927224 Tbc1d25 - TBC1 domain family member 25 - Mus musculus (Mouse) - Tbc1d25 gene Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. Taurus_UMD|evm.model.AC_000187.1.859 W8E7I1 RBM3_CAPHI 99.375 0.987578 1.00625 RBM3 - RNA-binding protein 3 - Capra hircus (Goat) - RBM3 gene Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation. Taurus_UMD|evm.model.AC_000187.1.860 Q5RF24 WDR13_PONAB 100.000 0.995885 1.00206 WDR13 - WD repeat-containing protein 13 - Pongo abelii (Sumatran orangutan) - WDR13 gene Taurus_UMD|evm.model.AC_000187.1.861 Q32PB0 SSBP_BOVIN 97.500 0.991667 0.810811 SSBP1 - Single-stranded DNA-binding protein, mitochondrial precursor - Bos taurus (Bovine) - SSBP1 gene Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair. Taurus_UMD|evm.model.AC_000187.1.862 P42768 WASP_HUMAN 94.805 0.449704 0.336653 WAS - Wiskott-Aldrich syndrome protein - Homo sapiens (Human) - WAS gene Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:8625410, PubMed:12235133, PubMed:16275905). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Taurus_UMD|evm.model.AC_000187.1.863 P42768 WASP_HUMAN 89.773 0.769912 0.2251 WAS - Wiskott-Aldrich syndrome protein - Homo sapiens (Human) - WAS gene Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:8625410, PubMed:12235133, PubMed:16275905). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Taurus_UMD|evm.model.AC_000187.1.864 Q2NL30 SUV91_BOVIN 99.515 0.995157 1.00243 SUV39H1 - Histone-lysine N-methyltransferase SUV39H1 - Bos taurus (Bovine) - SUV39H1 gene Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity). Taurus_UMD|evm.model.AC_000187.1.865 Q7ZVG6 SIAH1_DANRE 85.156 0.984496 0.457447 siah1 - E3 ubiquitin-protein ligase Siah1 - Danio rerio (Zebrafish) - siah1 gene E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Taurus_UMD|evm.model.AC_000187.1.866 P15976 GATA1_HUMAN 91.389 0.591736 1.46489 GATA1 - Erythroid transcription factor - Homo sapiens (Human) - GATA1 gene Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). Taurus_UMD|evm.model.AC_000187.1.867 Q9UBN7 HDAC6_HUMAN 73.934 0.996473 0.933333 HDAC6 - Histone deacetylase 6 - Homo sapiens (Human) - HDAC6 gene Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10220385). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10220385). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:10220385). In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). Taurus_UMD|evm.model.AC_000187.1.868 Q7Z444 RASE_HUMAN 77.350 0.6793 1.4721 ERAS - GTPase ERas precursor - Homo sapiens (Human) - ERAS gene Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity). Taurus_UMD|evm.model.AC_000187.1.869 Q9UHG2 PCS1N_HUMAN 87.645 0.992308 1 PCSK1N - ProSAAS precursor - Homo sapiens (Human) - PCSK1N gene May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known (By similarity). Taurus_UMD|evm.model.AC_000187.1.870 Q2HJE9 TI17B_BOVIN 99.419 0.988439 1.00581 TIMM17B - Mitochondrial import inner membrane translocase subunit Tim17-B - Bos taurus (Bovine) - TIMM17B gene Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Taurus_UMD|evm.model.AC_000187.1.871 Q2HJC9 PQBP1_BOVIN 100.000 0.992424 1.0038 PQBP1 - Polyglutamine-binding protein 1 - Bos taurus (Bovine) - PQBP1 gene Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production. Taurus_UMD|evm.model.AC_000187.1.872 Q58DA6 S35A2_BOVIN 99.491 0.994924 1.00254 SLC35A2 - UDP-galactose translocator - Bos taurus (Bovine) - SLC35A2 gene Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function. Taurus_UMD|evm.model.AC_000187.1.873 Q9P1W9 PIM2_HUMAN 91.961 0.99359 1.00322 PIM2 - Serine/threonine-protein kinase pim-2 - Homo sapiens (Human) - PIM2 gene Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate. Taurus_UMD|evm.model.AC_000187.1.874 Q2YDU3 OTUD5_RAT 98.410 0.996473 1.00177 Otud5 - OTU domain-containing protein 5 - Rattus norvegicus (Rat) - Otud5 gene Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (By similarity). Taurus_UMD|evm.model.AC_000187.1.875 Q52PG9 KCND1_BOVIN 100.000 0.996918 1.00154 KCND1 - Potassium voltage-gated channel subfamily D member 1 - Bos taurus (Bovine) - KCND1 gene Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (By similarity). Taurus_UMD|evm.model.AC_000187.1.876 Q4V328 GRAP1_HUMAN 94.768 0.997625 1.00119 GRIPAP1 - GRIP1-associated protein 1 - Homo sapiens (Human) - GRIPAP1 gene Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). Taurus_UMD|evm.model.AC_000187.1.877 Q05B92 TFE3_BOVIN 100.000 0.996516 1.00175 TFE3 - Transcription factor E3 - Bos taurus (Bovine) - TFE3 gene Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (By similarity). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation. Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in nuclear localization and transcription factor activity (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site. May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (By similarity). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue. Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent nuclear exclusion promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (By similarity). Taurus_UMD|evm.model.AC_000187.1.879 Q96HB5 CC120_HUMAN 91.429 0.948718 1.05238 CCDC120 - Coiled-coil domain-containing protein 120 - Homo sapiens (Human) - CCDC120 gene Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. Taurus_UMD|evm.model.AC_000187.1.880 Q2KHX3 PRAF2_BOVIN 100.000 0.988827 1.00562 PRAF2 - PRA1 family protein 2 - Bos taurus (Bovine) - PRAF2 gene May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis (By similarity). Taurus_UMD|evm.model.AC_000187.1.881 Q9Y484 WIPI4_HUMAN 99.167 0.99446 1.00278 WDR45 - WD repeat domain phosphoinositide-interacting protein 4 - Homo sapiens (Human) - WDR45 gene Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066). Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066). Taurus_UMD|evm.model.AC_000187.1.882 P39032 RL36_RAT 81.609 0.86 0.952381 Rpl36 - 60S ribosomal protein L36 - Rattus norvegicus (Rat) - Rpl36 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000187.1.883 Q92917 GPKOW_HUMAN 79.630 0.995842 1.0105 GPKOW - G-patch domain and KOW motifs-containing protein - Homo sapiens (Human) - GPKOW gene RNA-binding protein involved in pre-mRNA splicing. Taurus_UMD|evm.model.AC_000187.1.884 Q9H6Y5 MAGIX_HUMAN 72.308 0.941176 0.203593 MAGIX - PDZ domain-containing protein MAGIX - Homo sapiens (Human) - MAGIX gene Taurus_UMD|evm.model.AC_000187.1.885 Q9H6Y5 MAGIX_HUMAN 68.935 0.994083 1.01198 MAGIX - PDZ domain-containing protein MAGIX - Homo sapiens (Human) - MAGIX gene Taurus_UMD|evm.model.AC_000187.1.886 Q6Y1E2 PLP2_BOVIN 100.000 0.986928 1.00658 PLP2 - Proteolipid protein 2 - Bos taurus (Bovine) - PLP2 gene May play a role in cell differentiation in the intestinal epithelium. Taurus_UMD|evm.model.AC_000187.1.887 Q80VL3 PRIC3_MOUSE 91.387 0.764895 0.995192 Prickle3 - Prickle planar cell polarity protein 3 - Mus musculus (Mouse) - Prickle3 gene Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135). Taurus_UMD|evm.model.AC_000187.1.888 P20488 SYPH_BOVIN 99.361 0.993631 1.00319 SYP - Synaptophysin - Bos taurus (Bovine) - SYP gene Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). Taurus_UMD|evm.model.AC_000187.1.889 O60840 CAC1F_HUMAN 91.556 0.926988 0.935255 CACNA1F - Voltage-dependent L-type calcium channel subunit alpha-1F - Homo sapiens (Human) - CACNA1F gene Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization. Taurus_UMD|evm.model.AC_000187.1.890 Q1RMI8 CCD22_BOVIN 94.896 0.996815 1.05546 CCDC22 - Coiled-coil domain-containing protein 22 - Bos taurus (Bovine) - CCDC22 gene Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Taurus_UMD|evm.model.AC_000187.1.891 Q6U8D7 FOXP3_MACFA 90.255 0.928726 1.07425 FOXP3 - Forkhead box protein P3 - Macaca fascicularis (Crab-eating macaque) - FOXP3 gene Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7. Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1. Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development. Inhibits the transcriptional activator activity of RORA. Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4. Taurus_UMD|evm.model.AC_000187.1.892 Q6ZSY5 PPR3F_HUMAN 82.924 0.996287 1.01126 PPP1R3F - Protein phosphatase 1 regulatory subunit 3F - Homo sapiens (Human) - PPP1R3F gene Glycogen-targeting subunit for protein phosphatase 1 (PP1). Taurus_UMD|evm.model.AC_000187.1.893 Q5JUK9 PAGE3_HUMAN 56.757 0.688679 0.938053 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Taurus_UMD|evm.model.AC_000187.1.894 A6NNY8 UBP27_HUMAN 98.174 0.590541 1.6895 USP27X - Ubiquitin carboxyl-terminal hydrolase 27 - Homo sapiens (Human) - USP27X gene Deubiquitinase that can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal. By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity. Taurus_UMD|evm.model.AC_000187.1.895 Q2M218 ZN630_HUMAN 76.159 0.738916 0.30898 ZNF630 - Zinc finger protein 630 - Homo sapiens (Human) - ZNF630 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.896 Q32PD6 LYZL5_BOVIN 100.000 0.987261 1.00641 SPACA5 - Sperm acrosome-associated protein 5 precursor - Bos taurus (Bovine) - SPACA5 gene Taurus_UMD|evm.model.AC_000187.1.897 P17025 ZN182_HUMAN 92.730 0.9872 0.978091 ZNF182 - Zinc finger protein 182 - Homo sapiens (Human) - ZNF182 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.898 Q9GKE7 CLCN5_PIG 97.992 0.997326 0.916667 CLCN5 - H(+)/Cl(-) exchange transporter 5 - Sus scrofa (Pig) - CLCN5 gene Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). Taurus_UMD|evm.model.AC_000187.1.899 Q5RAF3 NMT1_PONAB 73.109 0.906977 0.260081 NMT1 - Glycylpeptide N-tetradecanoyltransferase 1 - Pongo abelii (Sumatran orangutan) - NMT1 gene Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Taurus_UMD|evm.model.AC_000187.1.901 Q60662 AKAP4_MOUSE 81.301 0.993031 1.01413 Akap4 - A-kinase anchor protein 4 precursor - Mus musculus (Mouse) - Akap4 gene Major structural component of sperm fibrous sheath. Plays a role in sperm motility (PubMed:12167408). Taurus_UMD|evm.model.AC_000187.1.902 P39963 CCNB3_CHICK 55.882 0.185591 3.16873 CCNB3 - G2/mitotic-specific cyclin-B3 - Gallus gallus (Chicken) - CCNB3 gene Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Could be involved at the G2/M (mitosis or meiosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Taurus_UMD|evm.model.AC_000187.1.903 Q5KSL6 DGKK_HUMAN 86.094 0.974975 0.785995 DGKK - Diacylglycerol kinase kappa - Homo sapiens (Human) - DGKK gene Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:16210324, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Taurus_UMD|evm.model.AC_000187.1.905 Q64478 H2B1H_MOUSE 91.270 0.984252 1.00794 H2bc9 - Histone H2B type 1-H - Mus musculus (Mouse) - H2bc9 gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000187.1.906 P39942 VATD_BOVIN 91.667 0.989637 0.781377 ATP6V1D - V-type proton ATPase subunit D - Bos taurus (Bovine) - ATP6V1D gene Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). Taurus_UMD|evm.model.AC_000187.1.908 Q6PX77 BMP15_BOVIN 100.000 0.972772 1.02538 BMP15 - Bone morphogenetic protein 15 precursor - Bos taurus (Bovine) - BMP15 gene May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). Taurus_UMD|evm.model.AC_000187.1.909 Q58CW0 NUD11_BOVIN 99.115 0.982456 0.695122 NUDT11 - Diphosphoinositol polyphosphate phosphohydrolase 3-beta - Bos taurus (Bovine) - NUDT11 gene Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Taurus_UMD|evm.model.AC_000187.1.910 Q86X51 EZHIP_HUMAN 35.503 0.344519 0.888668 EZHIP - EZH inhibitory protein - Homo sapiens (Human) - EZHIP gene Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:31086175, PubMed:31451685, PubMed:30923826). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). Taurus_UMD|evm.model.AC_000187.1.912 Q58CW0 NUD11_BOVIN 99.390 0.987879 1.0061 NUDT11 - Diphosphoinositol polyphosphate phosphohydrolase 3-beta - Bos taurus (Bovine) - NUDT11 gene Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Taurus_UMD|evm.model.AC_000187.1.913 Q9P203 BTBD7_HUMAN 80.583 0.980392 0.090106 BTBD7 - BTB/POZ domain-containing protein 7 - Homo sapiens (Human) - BTBD7 gene Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). Taurus_UMD|evm.model.AC_000187.1.914 P15170 ERF3A_HUMAN 93.587 0.78481 1.26653 GSPT1 - Eukaryotic peptide chain release factor GTP-binding subunit ERF3A - Homo sapiens (Human) - GSPT1 gene Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activity of ETF1 (By similarity). Involved in regulation of mammalian cell growth (PubMed:2511002). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). Taurus_UMD|evm.model.AC_000187.1.915 Q96KR1 ZFR_HUMAN 92.417 0.967742 0.202048 ZFR - Zinc finger RNA-binding protein - Homo sapiens (Human) - ZFR gene Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). Taurus_UMD|evm.model.AC_000187.1.916 O88532 ZFR_MOUSE 94.949 0.98995 0.185289 Zfr - Zinc finger RNA-binding protein - Mus musculus (Mouse) - Zfr gene Involved in postimplantation and gastrulation stages of development. Binds to DNA and RNA. Involved in the nucleocytoplasmic shuttling of STAU2 (By similarity). Taurus_UMD|evm.model.AC_000187.1.917 Q5R8F7 PABP1_PONAB 94.488 0.992157 0.400943 PABPC1 - Polyadenylate-binding protein 1 - Pongo abelii (Sumatran orangutan) - PABPC1 gene Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability. Taurus_UMD|evm.model.AC_000187.1.918 Q5JUK9 PAGE3_HUMAN 46.809 0.823009 1 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Taurus_UMD|evm.model.AC_000187.1.919 Q5JUK9 PAGE3_HUMAN 52.222 0.463542 1.69912 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Taurus_UMD|evm.model.AC_000187.1.920 Q5JUK9 PAGE3_HUMAN 42.857 0.731707 1.0885 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Taurus_UMD|evm.model.AC_000187.1.921 Q5JUK9 PAGE3_HUMAN 51.579 0.783333 1.06195 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Taurus_UMD|evm.model.AC_000187.1.922 Q5JUK9 PAGE3_HUMAN 50.515 0.761905 1.11504 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Taurus_UMD|evm.model.AC_000187.1.923 A6QLI5 MAGD4_BOVIN 98.592 0.721649 0.131081 MAGED4 - Melanoma-associated antigen D4 - Bos taurus (Bovine) - MAGED4 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). Taurus_UMD|evm.model.AC_000187.1.924 A6QLI5 MAGD4_BOVIN 99.595 0.994616 1.00405 MAGED4 - Melanoma-associated antigen D4 - Bos taurus (Bovine) - MAGED4 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). Taurus_UMD|evm.model.AC_000187.1.925 Q6ITT4 MAGD1_PIG 91.593 0.997455 1.00255 MAGED1 - Melanoma-associated antigen D1 - Sus scrofa (Pig) - MAGED1 gene Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed (By similarity). Taurus_UMD|evm.model.AC_000187.1.926 Q5E9H8 GP173_BOVIN 100.000 0.994652 1.00268 GPR173 - Probable G-protein coupled receptor 173 - Bos taurus (Bovine) - GPR173 gene Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20 (By similarity). It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland (By similarity). In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth (By similarity). Taurus_UMD|evm.model.AC_000187.1.927 Q9BE64 TSYL2_MACFA 69.972 0.997183 1.02158 TSPYL2 - Testis-specific Y-encoded-like protein 2 - Macaca fascicularis (Crab-eating macaque) - TSPYL2 gene Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression (By similarity). Taurus_UMD|evm.model.AC_000187.1.928 Q2TGK3 ZDHC3_RAT 82.955 0.992337 0.87291 Zdhhc3 - Palmitoyltransferase ZDHHC3 - Rattus norvegicus (Rat) - Zdhhc3 gene Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (By similarity). Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (By similarity). Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (By similarity). In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation. Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses. Palmitoylates NCDN thereby regulating its association with endosome membranes. Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor. Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth. Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes (By similarity). Also constitutively palmitoylates DLG4 (PubMed:19596852). May also palmitoylate SNAP25. Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (By similarity). Could also palmitoylate the D(2) dopamine receptor DRD2. Taurus_UMD|evm.model.AC_000187.1.929 Q38JA7 KDM5C_CANLF 97.752 0.998715 1 KDM5C - Lysine-specific demethylase 5C - Canis lupus familiaris (Dog) - KDM5C gene Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. Taurus_UMD|evm.model.AC_000187.1.930 Q5DU25 IQEC2_MOUSE 98.332 0.873611 0.97429 Iqsec2 - IQ motif and SEC7 domain-containing protein 2 - Mus musculus (Mouse) - Iqsec2 gene Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins. Taurus_UMD|evm.model.AC_000187.1.931 O97593 SMC1A_BOVIN 99.736 0.871637 1.05515 SMC1A - Structural maintenance of chromosomes protein 1A - Bos taurus (Bovine) - SMC1A gene Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint (By similarity). Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. Taurus_UMD|evm.model.AC_000187.1.932 Q0VC09 RIBC1_BOVIN 99.736 0.986945 1.01055 RIBC1 - RIB43A-like with coiled-coils protein 1 - Bos taurus (Bovine) - RIBC1 gene Taurus_UMD|evm.model.AC_000187.1.933 O02691 HCD2_BOVIN 100.000 0.992366 1.00383 HSD17B10 - 3-hydroxyacyl-CoA dehydrogenase type-2 - Bos taurus (Bovine) - HSD17B10 gene Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism. Acts as (S)-3-hydroxyacyl-CoA dehydrogenase in mitochondrial fatty acid beta-oxidation, a major degradation pathway of fatty acids. Catalyzes the third step in the beta-oxidation cycle, namely the reversible conversion of (S)-3-hydroxyacyl-CoA to 3-ketoacyl-CoA. Preferentially accepts straight medium- and short-chain acyl-CoA substrates with highest efficiency for (3S)-hydroxybutanoyl-CoA. Acts as 3-hydroxy-2-methylbutyryl-CoA dehydrogenase in branched-chain amino acid catabolic pathway. Catalyzes the oxidation of 3-hydroxy-2-methylbutanoyl-CoA into 2-methyl-3-oxobutanoyl-CoA, a step in isoleucine degradation pathway. Has hydroxysteroid dehydrogenase activity toward steroid hormones and bile acids. Catalyzes the oxidation of 3alpha-, 17beta-, 20beta- and 21-hydroxysteroids and 7alpha- and 7beta-hydroxy bile acids. Oxidizes allopregnanolone/brexanolone at the 3alpha-hydroxyl group, which is known to be critical for the activation of gamma-aminobutyric acid receptors (GABAARs) chloride channel. Has phospholipase C-like activity toward cardiolipin and its oxidized species. Likely oxidizes the 2'-hydroxyl in the head group of cardiolipin to form a ketone intermediate that undergoes nucleophilic attack by water and fragments into diacylglycerol, dihydroxyacetone and orthophosphate. Has higher affinity for cardiolipin with oxidized fatty acids and may degrade these species during the oxidative stress response to protect cells from apoptosis. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Essential for structural and functional integrity of mitochondria. Taurus_UMD|evm.model.AC_000187.1.934 P51593 HUWE1_RAT 100.000 0.0726573 13.7205 Huwe1 - E3 ubiquitin-protein ligase HUWE1 - Rattus norvegicus (Rat) - Huwe1 gene E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (By similarity). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (By similarity). Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (By similarity). Mediates polyubiquitination of PA2G4 (By similarity). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (By similarity). Taurus_UMD|evm.model.AC_000187.1.935 O15347 HMGB3_HUMAN 81.548 0.813131 0.99 HMGB3 - High mobility group protein B3 - Homo sapiens (Human) - HMGB3 gene Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). Taurus_UMD|evm.model.AC_000187.1.936 Q9UPP1 PHF8_HUMAN 95.545 0.920524 1.08019 PHF8 - Histone lysine demethylase PHF8 - Homo sapiens (Human) - PHF8 gene Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Taurus_UMD|evm.model.AC_000187.1.937 Q6IRU2 TPM4_MOUSE 80.000 0.935484 0.5 Tpm4 - Tropomyosin alpha-4 chain - Mus musculus (Mouse) - Tpm4 gene Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. Taurus_UMD|evm.model.AC_000187.1.938 Q9NX05 F120C_HUMAN 93.163 0.860861 0.911496 FAM120C - Constitutive coactivator of PPAR-gamma-like protein 2 - Homo sapiens (Human) - FAM120C gene nucleus, RNA binding Taurus_UMD|evm.model.AC_000187.1.939 Q9BYP7 WNK3_HUMAN 92.342 0.455952 0.826111 WNK3 - Serine/threonine-protein kinase WNK3 - Homo sapiens (Human) - WNK3 gene Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, PubMed:16275911, PubMed:16357011). Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner. Taurus_UMD|evm.model.AC_000187.1.940 Q3T090 TSR2_BOVIN 100.000 0.984375 1.01053 TSR2 - Pre-rRNA-processing protein TSR2 homolog - Bos taurus (Bovine) - TSR2 gene May be involved in 20S pre-rRNA processing. Taurus_UMD|evm.model.AC_000187.1.941 P98174 FGD1_HUMAN 95.838 0.997919 1 FGD1 - FYVE, RhoGEF and PH domain-containing protein 1 - Homo sapiens (Human) - FGD1 gene Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Taurus_UMD|evm.model.AC_000187.1.942 Q3T0J9 GNL3L_BOVIN 100.000 0.996528 1.00174 GNL3L - Guanine nucleotide-binding protein-like 3-like protein - Bos taurus (Bovine) - GNL3L gene Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP (By similarity). Taurus_UMD|evm.model.AC_000187.1.943 Q6UXX5 ITIH6_HUMAN 66.667 0.734597 0.160701 ITIH6 - Inter-alpha-trypsin inhibitor heavy chain H6 precursor - Homo sapiens (Human) - ITIH6 gene Taurus_UMD|evm.model.AC_000187.1.944 Q12816 TROP_HUMAN 63.936 0.975369 0.567435 TRO - Trophinin - Homo sapiens (Human) - TRO gene Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion. Taurus_UMD|evm.model.AC_000187.1.945 P49872 F261_BOVIN 99.575 0.995763 1.00212 PFKFB1 - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 - Bos taurus (Bovine) - PFKFB1 gene Synthesis and degradation of fructose 2,6-bisphosphate. Taurus_UMD|evm.model.AC_000187.1.946 Q5E9N9 APEX2_BOVIN 99.805 0.996117 1.00195 APEX2 - DNA-(apurinic or apyrimidinic site) endonuclease 2 - Bos taurus (Bovine) - APEX2 gene Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity). Taurus_UMD|evm.model.AC_000187.1.947 Q3ZC31 HEM0_BOVIN 100.000 0.996599 1.0017 ALAS2 - 5-aminolevulinate synthase, erythroid-specific, mitochondrial precursor - Bos taurus (Bovine) - ALAS2 gene mitochondrial inner membrane, mitochondrion, 5-aminolevulinate synthase activity, erythrocyte development, heme biosynthetic process, hemoglobin biosynthetic process, response to hypoxia Taurus_UMD|evm.model.AC_000187.1.948 Q8NDB6 FA156_HUMAN 43.382 0.956204 0.643192 FAM156A - Protein FAM156A/FAM156B - Homo sapiens (Human) - FAM156A gene nuclear envelope Taurus_UMD|evm.model.AC_000187.1.949 Q9H213 MAGH1_HUMAN 93.878 0.886364 1.00457 MAGEH1 - Melanoma-associated antigen H1 - Homo sapiens (Human) - MAGEH1 gene apoptotic process Taurus_UMD|evm.model.AC_000187.1.950 O00370 LORF2_HUMAN 73.668 0.972477 0.256471 LINE-1 retrotransposable element ORF2 protein - Homo sapiens (Human) Taurus_UMD|evm.model.AC_000187.1.951 Q6PJQ5 FOXR2_HUMAN 68.987 0.993691 1.01929 FOXR2 - Forkhead box protein R2 - Homo sapiens (Human) - FOXR2 gene chromatin, nucleoplasm, nucleus, DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific double-stranded DNA binding Taurus_UMD|evm.model.AC_000187.1.952 Q63486 RRAGA_RAT 98.083 0.899135 1.10863 Rraga - Ras-related GTP-binding protein A - Rattus norvegicus (Rat) - Rraga gene Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. Taurus_UMD|evm.model.AC_000187.1.953 O95600 KLF8_HUMAN 85.490 0.902878 0.774373 KLF8 - Krueppel-like factor 8 - Homo sapiens (Human) - KLF8 gene Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). Taurus_UMD|evm.model.AC_000187.1.954 Q4R6E8 LAP4B_MACFA 73.034 0.967033 0.402655 LAPTM4B - Lysosomal-associated transmembrane protein 4B - Macaca fascicularis (Crab-eating macaque) - LAPTM4B gene Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways. Taurus_UMD|evm.model.AC_000187.1.955 Q9UHD9 UBQL2_HUMAN 96.474 0.9968 1.0016 UBQLN2 - Ubiquilin-2 - Homo sapiens (Human) - UBQLN2 gene Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683). Taurus_UMD|evm.model.AC_000187.1.956 Q9Y6I9 TX264_HUMAN 65.591 0.978723 0.300319 TEX264 - Testis-expressed protein 264 - Homo sapiens (Human) - TEX264 gene Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537). Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270). Taurus_UMD|evm.model.AC_000187.1.957 P61078 UB2D3_RAT 65.657 0.915663 0.564626 Ube2d3 - Ubiquitin-conjugating enzyme E2 D3 - Rattus norvegicus (Rat) - Ube2d3 gene Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). Taurus_UMD|evm.model.AC_000187.1.958 Q5RAW7 SPIN3_PONAB 92.793 0.859375 0.496124 SPIN3 - Spindlin-3 - Pongo abelii (Sumatran orangutan) - SPIN3 gene Exhibits H3K4me3-binding activity. Taurus_UMD|evm.model.AC_000187.1.959 Q2KI39 SPIN2_BOVIN 100.000 0.747093 1.33333 SPIN2 - Spindlin-2 - Bos taurus (Bovine) - SPIN2 gene May be involved in the regulation of cell cycle progression. Exhibits H3K4me3-binding activity. Taurus_UMD|evm.model.AC_000187.1.960 Q5RA80 SPIN2_PONAB 94.961 0.992278 1.00388 SPIN2 - Spindlin-2 - Pongo abelii (Sumatran orangutan) - SPIN2 gene May be involved in the regulation of cell cycle progression. Exhibits H3K4me3-binding activity. Taurus_UMD|evm.model.AC_000187.1.961 Q5RA80 SPIN2_PONAB 85.271 0.992278 1.00388 SPIN2 - Spindlin-2 - Pongo abelii (Sumatran orangutan) - SPIN2 gene May be involved in the regulation of cell cycle progression. Exhibits H3K4me3-binding activity. Taurus_UMD|evm.model.AC_000187.1.962 P62961 YBOX1_RAT 66.292 0.271605 1.00621 Ybx1 - Y-box-binding protein 1 - Rattus norvegicus (Rat) - Ybx1 gene DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation. Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay. Component of the CRD-mediated complex that promotes MYC mRNA stability (By similarity). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs. Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs. Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs. Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection. Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair. The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (By similarity). Taurus_UMD|evm.model.AC_000187.1.963 P21573 YBOX1_XENLA 59.551 0.335878 0.864686 ybx1 - Y-box-binding protein 1 - Xenopus laevis (African clawed frog) - ybx1 gene DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation (By similarity). Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (By similarity). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and preventing mRNA decay (By similarity). Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation (By similarity). Also promotes maternal-to-zygotic transition in oocytes and embryos by promoting translation repression; molecular mechanisms governing translation repression are unknown (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (By similarity). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (By similarity). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (By similarity). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (By similarity). Also able to bind DNA and regulate transcription (PubMed:2247479). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3') (PubMed:2247479). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (By similarity). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (By similarity). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (By similarity). Taurus_UMD|evm.model.AC_000187.1.964 Q9BQS7 HEPH_HUMAN 89.551 0.978849 1.02073 HEPH - Hephaestin precursor - Homo sapiens (Human) - HEPH gene May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1. Taurus_UMD|evm.model.AC_000187.1.965 Q9Y279 VSIG4_HUMAN 87.121 0.454545 0.716792 VSIG4 - V-set and immunoglobulin domain-containing protein 4 precursor - Homo sapiens (Human) - VSIG4 gene Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. Taurus_UMD|evm.model.AC_000187.1.966 Q03274 PO22_POPJA 33.036 0.458333 0.337553 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 - Popillia japonica (Japanese beetle) Taurus_UMD|evm.model.AC_000187.1.967 Q32L59 TMC5B_BOVIN 81.818 0.153571 0.797721 TMCO5B - Transmembrane and coiled-coil domain-containing protein 5B - Bos taurus (Bovine) - TMCO5B gene Taurus_UMD|evm.model.AC_000187.1.968 Q2HJ49 MOES_BOVIN 100.000 0.99654 1.00173 MSN - Moesin - Bos taurus (Bovine) - MSN gene Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (By similarity). Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation (By similarity). Taurus_UMD|evm.model.AC_000187.1.969 Q9Y4W2 LAS1L_HUMAN 80.645 0.931732 1.07766 LAS1L - Ribosomal biogenesis protein LAS1L - Homo sapiens (Human) - LAS1L gene Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Taurus_UMD|evm.model.AC_000187.1.970 Q5HYM0 ZC12B_HUMAN 92.455 0.996416 1.0012 ZC3H12B - Probable ribonuclease ZC3H12B - Homo sapiens (Human) - ZC3H12B gene May function as RNase and regulate the levels of target RNA species. Taurus_UMD|evm.model.AC_000187.1.972 Q8N6M0 OTU6B_HUMAN 57.919 0.975155 0.549488 OTUD6B - Deubiquitinase OTUD6B - Homo sapiens (Human) - OTUD6B gene Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334). May also play a role in proteasome assembly and function (PubMed:28343629). Taurus_UMD|evm.model.AC_000187.1.973 Q68FG0 ZC4H2_MOUSE 99.554 0.991111 1.00446 Zc4h2 - Zinc finger C4H2 domain-containing protein - Mus musculus (Mouse) - Zc4h2 gene Plays a role in interneurons differentiation. Involved in neuronal development and in neuromuscular junction formation. Taurus_UMD|evm.model.AC_000187.1.974 Q9EPC6 PROF2_RAT 36.765 0.863636 1.1 Pfn2 - Profilin-2 - Rattus norvegicus (Rat) - Pfn2 gene Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity). Taurus_UMD|evm.model.AC_000187.1.975 Q8WXK4 ASB12_HUMAN 90.260 0.28022 3.53398 ASB12 - Ankyrin repeat and SOCS box protein 12 - Homo sapiens (Human) - ASB12 gene Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000187.1.976 Q5JTC6 AMER1_HUMAN 82.586 0.998214 0.986784 AMER1 - APC membrane recruitment protein 1 - Homo sapiens (Human) - AMER1 gene Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. Taurus_UMD|evm.model.AC_000187.1.977 Q58DL7 ARHG9_BOVIN 100.000 0.507246 1.96791 ARHGEF9 - Rho guanine nucleotide exchange factor 9 - Bos taurus (Bovine) - ARHGEF9 gene Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity). Taurus_UMD|evm.model.AC_000187.1.979 Q56A73 SPIN4_HUMAN 98.795 0.992 1.00402 SPIN4 - Spindlin-4 - Homo sapiens (Human) - SPIN4 gene Exhibits H3K4me3-binding activity. Taurus_UMD|evm.model.AC_000187.1.980 P21573 YBOX1_XENLA 68.539 0.237197 1.22442 ybx1 - Y-box-binding protein 1 - Xenopus laevis (African clawed frog) - ybx1 gene DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation (By similarity). Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (By similarity). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and preventing mRNA decay (By similarity). Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation (By similarity). Also promotes maternal-to-zygotic transition in oocytes and embryos by promoting translation repression; molecular mechanisms governing translation repression are unknown (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (By similarity). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (By similarity). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (By similarity). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (By similarity). Also able to bind DNA and regulate transcription (PubMed:2247479). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3') (PubMed:2247479). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (By similarity). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (By similarity). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (By similarity). Taurus_UMD|evm.model.AC_000187.1.981 P98169 ZXDB_HUMAN 83.599 0.997519 1.00374 ZXDB - Zinc finger X-linked protein ZXDB - Homo sapiens (Human) - ZXDB gene Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. Taurus_UMD|evm.model.AC_000187.1.982 P98169 ZXDB_HUMAN 84.417 0.997546 1.01494 ZXDB - Zinc finger X-linked protein ZXDB - Homo sapiens (Human) - ZXDB gene Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. Taurus_UMD|evm.model.AC_000187.1.984 Q9NY97 B3GN2_HUMAN 85.075 0.218033 1.53652 B3GNT2 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 - Homo sapiens (Human) - B3GNT2 gene Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. Taurus_UMD|evm.model.AC_000187.1.985 Q5JUW0 KRBX4_HUMAN 73.418 0.430939 1.05848 KRBOX4 - KRAB domain-containing protein 4 - Homo sapiens (Human) - KRBOX4 gene Taurus_UMD|evm.model.AC_000187.1.986 Q2M3X9 ZN674_HUMAN 79.002 0.99481 0.994836 ZNF674 - Zinc finger protein 674 - Homo sapiens (Human) - ZNF674 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.988 Q58CX7 DIK2B_BOVIN 99.048 0.683007 0.706697 DIPK2B - Divergent protein kinase domain 2B precursor - Bos taurus (Bovine) - DIPK2B gene Taurus_UMD|evm.model.AC_000187.1.989 O15550 KDM6A_HUMAN 98.485 0.984962 0.0949322 KDM6A - Lysine-specific demethylase 6A - Homo sapiens (Human) - KDM6A gene Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). Taurus_UMD|evm.model.AC_000187.1.990 O15550 KDM6A_HUMAN 93.505 0.998092 0.748037 KDM6A - Lysine-specific demethylase 6A - Homo sapiens (Human) - KDM6A gene Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). Taurus_UMD|evm.model.AC_000187.1.991 O70546 KDM6A_MOUSE 100.000 0.981132 0.0378301 Kdm6a - Lysine-specific demethylase 6A - Mus musculus (Mouse) - Kdm6a gene Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (By similarity). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (PubMed:21095589). Taurus_UMD|evm.model.AC_000187.1.992 O15550 KDM6A_HUMAN 98.667 0.649123 0.0813704 KDM6A - Lysine-specific demethylase 6A - Homo sapiens (Human) - KDM6A gene Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). Taurus_UMD|evm.model.AC_000187.1.993 Q5R8X2 DUS18_PONAB 76.344 0.939086 1.04787 DUSP18 - Dual specificity protein phosphatase 18 - Pongo abelii (Sumatran orangutan) - DUSP18 gene Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). Taurus_UMD|evm.model.AC_000187.1.994 P02552 TBA1_CHICK 59.890 0.956811 0.730583 Tubulin alpha-1 chain - Gallus gallus (Chicken) Taurus_UMD|evm.model.AC_000187.1.995 F1N5S9 FUND1_BOVIN 100.000 0.987179 1.00645 FUNDC1 - FUN14 domain-containing protein 1 - Bos taurus (Bovine) - FUNDC1 gene Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. Taurus_UMD|evm.model.AC_000187.1.996 O46415 FRIL_BOVIN 89.024 0.910112 0.508571 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000187.1.997 Q93075 TATD2_HUMAN 55.115 0.9968 0.821288 TATDN2 - Putative deoxyribonuclease TATDN2 - Homo sapiens (Human) - TATDN2 gene Putative deoxyribonuclease. Taurus_UMD|evm.model.AC_000187.1.998 Q5JST6 EFHC2_HUMAN 74.256 0.971014 0.921228 EFHC2 - EF-hand domain-containing family member C2 - Homo sapiens (Human) - EFHC2 gene axoneme, ciliary basal body, mitotic spindle, alpha-tubulin binding, cilium-dependent cell motility, mitotic cytokinesis, mitotic spindle organization, regulation of neuron projection development Taurus_UMD|evm.model.AC_000187.1.999 Q2KI78 NDP_BOVIN 100.000 0.985075 1.00752 NDP - Norrin precursor - Bos taurus (Bovine) - NDP gene Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction (By similarity). Taurus_UMD|evm.model.AC_000187.1.1000 P56560 AOFB_BOVIN 99.808 0.996161 1.00192 MAOB - Amine oxidase [flavin-containing] B - Bos taurus (Bovine) - MAOB gene Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). Taurus_UMD|evm.model.AC_000187.1.1001 P21398 AOFA_BOVIN 100.000 0.556025 1.79507 MAOA - Amine oxidase [flavin-containing] A - Bos taurus (Bovine) - MAOA gene Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Taurus_UMD|evm.model.AC_000187.1.1002 Q9P032 NDUF4_HUMAN 75.556 0.747899 0.68 NDUFAF4 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 - Homo sapiens (Human) - NDUFAF4 gene Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:18179882, PubMed:28853723). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion. Taurus_UMD|evm.model.AC_000187.1.1003 Q4R615 IPP2C_MACFA 55.072 0.943925 1.0439 PPP1R2C - Protein phosphatase inhibitor 2 family member C - Macaca fascicularis (Crab-eating macaque) - PPP1R2C gene Functions as a protein phosphatase inhibitor. It inhibits activity of the catalytic subunit of PP1 and weakly inhibits the activity of myosin-associated phosphates (By similarity). Taurus_UMD|evm.model.AC_000187.1.1004 O14936 CSKP_HUMAN 96.760 0.997773 0.969762 CASK - Peripheral plasma membrane protein CASK - Homo sapiens (Human) - CASK gene Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). Taurus_UMD|evm.model.AC_000187.1.1005 Q9GZU5 NYX_HUMAN 86.022 0.985138 0.97921 NYX - Nyctalopin precursor - Homo sapiens (Human) - NYX gene extracellular matrix, extracellular space Taurus_UMD|evm.model.AC_000187.1.1006 Q3SZQ6 RL32_BOVIN 76.923 0.820513 0.577778 RPL32 - 60S ribosomal protein L32 - Bos taurus (Bovine) - RPL32 gene cytosolic large ribosomal subunit Taurus_UMD|evm.model.AC_000187.1.1007 O00571 DDX3X_HUMAN 98.943 0.996979 1 DDX3X - ATP-dependent RNA helicase DDX3X - Homo sapiens (Human) - DDX3X gene Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:18628297, PubMed:17667941, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:31575075, PubMed:20127681, PubMed:21170385). Potentiate MAVS/DDX58-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:21170385, PubMed:27980081, PubMed:19913487). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). Taurus_UMD|evm.model.AC_000187.1.1008 Q93008 USP9X_HUMAN 98.019 0.999224 1.00861 USP9X - Probable ubiquitin carboxyl-terminal hydrolase FAF-X - Homo sapiens (Human) - USP9X gene Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration (PubMed:16322459, PubMed:18254724, PubMed:19135894, PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity (PubMed:29626158). Taurus_UMD|evm.model.AC_000187.1.1009 P24049 RL17_RAT 91.279 0.97076 0.929348 Rpl17 - 60S ribosomal protein L17 - Rattus norvegicus (Rat) - Rpl17 gene Component of the large ribosomal subunit. Taurus_UMD|evm.model.AC_000187.1.1010 O60244 MED14_HUMAN 97.868 0.998624 0.999312 MED14 - Mediator of RNA polymerase II transcription subunit 14 - Homo sapiens (Human) - MED14 gene Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Taurus_UMD|evm.model.AC_000187.1.1011 Q8TB03 CX038_HUMAN 87.821 0.990385 0.978056 CXorf38 - Uncharacterized protein CXorf38 - Homo sapiens (Human) - CXorf38 gene Taurus_UMD|evm.model.AC_000187.1.1012 Q2M2T3 MPCX_BOVIN 99.448 0.989011 1.00552 Mitochondrial pyruvate carrier-like protein - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000187.1.1013 P05386 RLA1_HUMAN 76.316 0.980392 0.894737 RPLP1 - 60S acidic ribosomal protein P1 - Homo sapiens (Human) - RPLP1 gene Plays an important role in the elongation step of protein synthesis. Taurus_UMD|evm.model.AC_000187.1.1014 P81134 RENR_BOVIN 99.413 0.788863 1.22792 ATP6AP2 - Renin receptor precursor - Bos taurus (Bovine) - ATP6AP2 gene Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (v-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (By similarity). Involved in many neuronal processes including synapse morphology and synaptic transmission (By similarity). Taurus_UMD|evm.model.AC_000187.1.1016 Q6W2J9 BCOR_HUMAN 87.323 0.98732 0.988604 BCOR - BCL-6 corepressor - Homo sapiens (Human) - BCOR gene Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). Taurus_UMD|evm.model.AC_000187.1.1019 Q9NPA3 M1IP1_HUMAN 93.443 0.989071 1 MID1IP1 - Mid1-interacting protein 1 - Homo sapiens (Human) - MID1IP1 gene Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity). Taurus_UMD|evm.model.AC_000187.1.1020 P41732 TSN7_HUMAN 97.590 0.992 1.00402 TSPAN7 - Tetraspanin-7 - Homo sapiens (Human) - TSPAN7 gene May be involved in cell proliferation and cell motility. Taurus_UMD|evm.model.AC_000187.1.1021 Q53VB8 FRIL_CANLF 55.866 0.988827 1.02286 FTL - Ferritin light chain - Canis lupus familiaris (Dog) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000187.1.1022 Q9N1U7 OTC_BOVIN 85.311 0.993443 0.861582 OTC - Ornithine transcarbamylase, mitochondrial precursor - Bos taurus (Bovine) - OTC gene Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion. Taurus_UMD|evm.model.AC_000187.1.1023 Q9R0X5 RPGR_MOUSE 80.769 0.520408 0.0979021 Rpgr - X-linked retinitis pigmentosa GTPase regulator precursor - Mus musculus (Mouse) - Rpgr gene Could be a guanine-nucleotide releasing factor (By similarity). Plays a role in ciliogenesis (By similarity). Probably regulates cilia formation by regulating actin stress filaments and cell contractility (By similarity). May be involved in microtubule organization and regulation of transport in primary cilia (By similarity). Plays an important role in photoreceptor integrity. Isoform 5 may play a critical role in spermatogenesis and in intraflagellar transport processes. Taurus_UMD|evm.model.AC_000187.1.1024 Q9N1T2 RPGR_CANLF 81.057 0.827839 0.272183 RPGR - X-linked retinitis pigmentosa GTPase regulator precursor - Canis lupus familiaris (Dog) - RPGR gene Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes. Taurus_UMD|evm.model.AC_000187.1.1025 Q9N1T2 RPGR_CANLF 63.339 0.993671 0.63011 RPGR - X-linked retinitis pigmentosa GTPase regulator precursor - Canis lupus familiaris (Dog) - RPGR gene Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes. Taurus_UMD|evm.model.AC_000187.1.1026 P78539 SRPX_HUMAN 90.517 0.995652 0.991379 SRPX - Sushi repeat-containing protein SRPX precursor - Homo sapiens (Human) - SRPX gene May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction. Taurus_UMD|evm.model.AC_000187.1.1027 Q812E4 SYTL5_RAT 72.346 0.949848 0.873838 Sytl5 - Synaptotagmin-like protein 5 - Rattus norvegicus (Rat) - Sytl5 gene May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids (By similarity). Taurus_UMD|evm.model.AC_000187.1.1028 Q9CQ70 H2AB1_MOUSE 61.798 0.745763 1.06306 H2ab1 - Histone H2A-Bbd type 1 - Mus musculus (Mouse) - H2ab1 gene Atypical histone H2A which replaces conventional H2A during late spermatogenesis and is involved in the replacement of histones to protamine in male germ cells (PubMed:28366643). Core component of nucleosome: nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (PubMed:19506029). Nucleosomes containing H2AB1 only wrap 130 bp of DNA, compared to 147 bp for classical nucleosomes (PubMed:19506029). In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) (PubMed:28366643). Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). Taurus_UMD|evm.model.AC_000187.1.1029 Q6XXL8 DYLT3_SHEEP 100.000 0.982906 1.00862 DYNLT3 - Dynein light chain Tctex-type 3 - Ovis aries (Sheep) - DYNLT3 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity). Taurus_UMD|evm.model.AC_000187.1.1030 O46522 CY24B_BOVIN 100.000 0.996497 1.00175 CYBB - Cytochrome b-245 heavy chain - Bos taurus (Bovine) - CYBB gene Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. Taurus_UMD|evm.model.AC_000187.1.1031 Q49LS5 XK_PANTR 80.663 0.947507 0.858108 XK - Membrane transport protein XK - Pan troglodytes (Chimpanzee) - XK gene May be involved in sodium-dependent transport of neutral amino acids or oligopeptides. Taurus_UMD|evm.model.AC_000187.1.1032 Q6ZV70 LANC3_HUMAN 96.905 0.995249 1.00238 LANCL3 - LanC-like protein 3 - Homo sapiens (Human) - LANCL3 gene plasma membrane Taurus_UMD|evm.model.AC_000187.1.1033 Q5R8J7 FRIH_PONAB 60.000 0.972826 1.00546 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Taurus_UMD|evm.model.AC_000187.1.1034 Q5R8J7 FRIH_PONAB 48.913 0.952128 1.02732 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Taurus_UMD|evm.model.AC_000187.1.1035 P08267 FRIH_CHICK 52.299 0.905759 1.06111 FTH - Ferritin heavy chain - Gallus gallus (Chicken) - FTH gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000187.1.1036 Q9BXU8 FHL17_HUMAN 58.580 0.843434 1.08197 FTHL17 - Ferritin heavy polypeptide-like 17 - Homo sapiens (Human) - FTHL17 gene cytoplasm, ferric iron binding, ferrous iron binding, ferroxidase activity, intracellular sequestering of iron ion Taurus_UMD|evm.model.AC_000187.1.1037 Q5HY64 FA47C_HUMAN 51.163 0.379147 0.407729 FAM47C - Putative protein FAM47C - Homo sapiens (Human) - FAM47C gene Taurus_UMD|evm.model.AC_000187.1.1038 A7Z070 TMG1_BOVIN 100.000 0.958084 0.766055 PRRG1 - Transmembrane gamma-carboxyglutamic acid protein 1 precursor - Bos taurus (Bovine) - PRRG1 gene Taurus_UMD|evm.model.AC_000187.1.1039 Q5R8J7 FRIH_PONAB 54.217 0.859375 1.04918 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Taurus_UMD|evm.model.AC_000187.1.1040 Q5R8J7 FRIH_PONAB 59.341 0.826484 1.19672 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Taurus_UMD|evm.model.AC_000187.1.1041 Q5R8J7 FRIH_PONAB 51.913 0.870813 1.14208 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Taurus_UMD|evm.model.AC_000187.1.1042 P29389 FRIH_CRIGR 55.814 0.929348 0.989247 FTH1 - Ferritin heavy chain - Cricetulus griseus (Chinese hamster) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000187.1.1043 Q5R8J7 FRIH_PONAB 59.341 0.826484 1.19672 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Taurus_UMD|evm.model.AC_000187.1.1045 P15907 SIAT1_HUMAN 77.419 0.3125 0.236453 ST6GAL1 - Beta-galactoside alpha-2,6-sialyltransferase 1 - Homo sapiens (Human) - ST6GAL1 gene Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. Taurus_UMD|evm.model.AC_000187.1.1046 Q9CQ70 H2AB1_MOUSE 58.000 0.838983 1.06306 H2ab1 - Histone H2A-Bbd type 1 - Mus musculus (Mouse) - H2ab1 gene Atypical histone H2A which replaces conventional H2A during late spermatogenesis and is involved in the replacement of histones to protamine in male germ cells (PubMed:28366643). Core component of nucleosome: nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (PubMed:19506029). Nucleosomes containing H2AB1 only wrap 130 bp of DNA, compared to 147 bp for classical nucleosomes (PubMed:19506029). In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) (PubMed:28366643). Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). Taurus_UMD|evm.model.AC_000187.1.1047 A2A368 MAGBG_HUMAN 67.421 0.711974 0.953704 MAGEB16 - Melanoma-associated antigen B16 - Homo sapiens (Human) - MAGEB16 gene Taurus_UMD|evm.model.AC_000187.1.1048 Q6ZTR5 CFA47_HUMAN 68.862 0.377358 0.831503 CFAP47 - Cilia- and flagella-associated protein 47 - Homo sapiens (Human) - CFAP47 gene Taurus_UMD|evm.model.AC_000187.1.1049 A2A368 MAGBG_HUMAN 53.145 0.933131 1.01543 MAGEB16 - Melanoma-associated antigen B16 - Homo sapiens (Human) - MAGEB16 gene Taurus_UMD|evm.model.AC_000187.1.1050 A2A368 MAGBG_HUMAN 58.261 0.947514 1.11728 MAGEB16 - Melanoma-associated antigen B16 - Homo sapiens (Human) - MAGEB16 gene Taurus_UMD|evm.model.AC_000187.1.1051 Q9TTY4 MAGBA_CANLF 64.103 0.902778 0.190476 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Taurus_UMD|evm.model.AC_000187.1.1052 A2A368 MAGBG_HUMAN 60.714 0.902439 0.759259 MAGEB16 - Melanoma-associated antigen B16 - Homo sapiens (Human) - MAGEB16 gene Taurus_UMD|evm.model.AC_000187.1.1053 Q5R4Z6 UB2V1_PONAB 55.814 0.959459 0.503401 UBE2V1 - Ubiquitin-conjugating enzyme E2 variant 1 - Pongo abelii (Sumatran orangutan) - UBE2V1 gene Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity). Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity). Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (By similarity). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. Taurus_UMD|evm.model.AC_000187.1.1054 Q5RCX4 ZN547_PONAB 38.298 0.227941 1.01493 ZNF547 - Zinc finger protein 547 - Pongo abelii (Sumatran orangutan) - ZNF547 gene May be involved in transcriptional regulation. Taurus_UMD|evm.model.AC_000187.1.1055 Q5W0B1 OBI1_HUMAN 88.981 0.997214 0.988981 OBI1 - ORC ubiquitin ligase 1 - Homo sapiens (Human) - OBI1 gene E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). Taurus_UMD|evm.model.AC_000187.1.1056 Q9BQJ4 TMM47_HUMAN 74.033 0.985185 0.745856 TMEM47 - Transmembrane protein 47 - Homo sapiens (Human) - TMEM47 gene Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity). Taurus_UMD|evm.model.AC_000187.1.1057 A6YRY8 RSSA_SHEEP 43.842 0.94382 0.60339 RPSA - 40S ribosomal protein SA - Ovis aries (Sheep) - RPSA gene Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. Taurus_UMD|evm.model.AC_000187.1.1058 Q5R8J7 FRIH_PONAB 67.442 0.934426 1 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Taurus_UMD|evm.model.AC_000187.1.1059 Q9NVW2 RNF12_HUMAN 50.226 0.685039 1.01763 RLIM - E3 ubiquitin-protein ligase RLIM - Homo sapiens (Human) - RLIM gene E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. Taurus_UMD|evm.model.AC_000187.1.1060 Q9NVW2 RNF12_HUMAN 68.519 0.169304 1.01282 RLIM - E3 ubiquitin-protein ligase RLIM - Homo sapiens (Human) - RLIM gene E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. Taurus_UMD|evm.model.AC_000187.1.1061 Q5R1W5 SRSF2_PANTR 64.646 0.502564 0.882353 SRSF2 - Serine/arginine-rich splicing factor 2 - Pan troglodytes (Chimpanzee) - SRSF2 gene Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity). Taurus_UMD|evm.model.AC_000187.1.1062 Q576B4 NU5M_BOSIN 90.598 0.983051 0.194719 MT-ND5 - NADH-ubiquinone oxidoreductase chain 5 - Bos indicus (Zebu) - MT-ND5 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. Taurus_UMD|evm.model.AC_000187.1.1063 Q5GN48 DMD_PIG 92.214 0.991228 0.372346 DMD - Dystrophin - Sus scrofa (Pig) - DMD gene Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. Taurus_UMD|evm.model.AC_000187.1.1064 Q5GN48 DMD_PIG 98.492 0.998117 0.289058 DMD - Dystrophin - Sus scrofa (Pig) - DMD gene Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. Taurus_UMD|evm.model.AC_000187.1.1065 Q5R8J7 FRIH_PONAB 45.902 0.942408 1.04372 FTH1 - Ferritin heavy chain - Pongo abelii (Sumatran orangutan) - FTH1 gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Taurus_UMD|evm.model.AC_000187.1.1066 Q3ZBM7 TRPT1_BOVIN 59.589 0.726316 0.748031 TRPT1 - tRNA 2'-phosphotransferase 1 - Bos taurus (Bovine) - TRPT1 gene Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. Taurus_UMD|evm.model.AC_000187.1.1067 Q8N5C8 TAB3_HUMAN 96.739 0.172348 0.741573 TAB3 - TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 - Homo sapiens (Human) - TAB3 gene Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:22158122). Taurus_UMD|evm.model.AC_000187.1.1068 Q0IID9 GLPK_BOVIN 98.611 0.988072 0.899821 GK - Glycerol kinase - Bos taurus (Bovine) - GK gene Key enzyme in the regulation of glycerol uptake and metabolism. Taurus_UMD|evm.model.AC_000187.1.1069 Q32LD7 TASL_BOVIN 99.667 0.993355 1.00333 TASL - TLR adapter interacting with SLC15A4 on the lysosome - Bos taurus (Bovine) - TASL gene Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons. Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes. Taurus_UMD|evm.model.AC_000187.1.1070 O95429 BAG4_HUMAN 74.830 0.986486 0.323851 BAG4 - BAG family molecular chaperone regulator 4 - Homo sapiens (Human) - BAG4 gene Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. Taurus_UMD|evm.model.AC_000187.1.1071 P79386 NR0B1_PIG 81.356 0.995763 1.00212 NR0B1 - Nuclear receptor subfamily 0 group B member 1 - Sus scrofa (Pig) - NR0B1 gene Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Taurus_UMD|evm.model.AC_000187.1.1072 P43366 MAGB1_HUMAN 56.646 0.911243 0.974063 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Taurus_UMD|evm.model.AC_000187.1.1073 Q8IXK0 PHC2_HUMAN 77.437 0.790244 0.477855 PHC2 - Polyhomeotic-like protein 2 - Homo sapiens (Human) - PHC2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Taurus_UMD|evm.model.AC_000187.1.1074 O15480 MAGB3_HUMAN 70.552 0.852632 0.549133 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Taurus_UMD|evm.model.AC_000187.1.1075 O15481 MAGB4_HUMAN 56.140 0.757848 1.28902 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1076 O15481 MAGB4_HUMAN 54.386 0.739606 1.32081 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1077 O15480 MAGB3_HUMAN 73.832 0.588889 0.520231 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Taurus_UMD|evm.model.AC_000187.1.1078 Q9TTY4 MAGBA_CANLF 67.816 0.117007 1.94444 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Taurus_UMD|evm.model.AC_000187.1.1079 O15481 MAGB4_HUMAN 53.235 0.768879 1.26301 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1081 O15481 MAGB4_HUMAN 62.937 0.601695 0.682081 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1082 P35129 UBC2_CAEEL 54.167 0.952381 0.428571 let-70 - Ubiquitin-conjugating enzyme E2 2 - Caenorhabditis elegans - let-70 gene Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Mediates the selective degradation of short-lived and abnormal proteins. Plays a role in the DNA damage response (PubMed:16628214). In particular, in response to ionizing radiation, associates with the E3 ubiquitin-protein ligase brc-1-brd-1 heterodimer on chromatin to activate E3-ubiquitin ligase activity of the heterodimer, and thus its DNA damage repair mechanisms (PubMed:16628214). Taurus_UMD|evm.model.AC_000187.1.1083 O15481 MAGB4_HUMAN 53.648 0.868914 0.771676 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1097 O15481 MAGB4_HUMAN 66.154 0.259184 1.41618 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1098 O15481 MAGB4_HUMAN 60.577 0.892241 0.67052 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1099 O15481 MAGB4_HUMAN 48.679 0.623223 1.21965 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1100 Q9TTY4 MAGBA_CANLF 70.588 0.631579 0.351852 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Taurus_UMD|evm.model.AC_000187.1.1101 O15481 MAGB4_HUMAN 76.623 0.177156 1.23988 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1102 O15479 MAGB2_HUMAN 57.229 0.128006 4.04075 MAGEB2 - Melanoma-associated antigen B2 - Homo sapiens (Human) - MAGEB2 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Taurus_UMD|evm.model.AC_000187.1.1103 Q9TTY4 MAGBA_CANLF 70.149 0.175066 0.997354 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Taurus_UMD|evm.model.AC_000187.1.1104 Q8IXK0 PHC2_HUMAN 75.646 0.882812 0.298368 PHC2 - Polyhomeotic-like protein 2 - Homo sapiens (Human) - PHC2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Taurus_UMD|evm.model.AC_000187.1.1105 Q8IXK0 PHC2_HUMAN 82.812 0.473684 0.155012 PHC2 - Polyhomeotic-like protein 2 - Homo sapiens (Human) - PHC2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Taurus_UMD|evm.model.AC_000187.1.1106 Q8IXK0 PHC2_HUMAN 86.550 0.729614 0.271562 PHC2 - Polyhomeotic-like protein 2 - Homo sapiens (Human) - PHC2 gene Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Taurus_UMD|evm.model.AC_000187.1.1107 O15480 MAGB3_HUMAN 74.101 0.831325 0.479769 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Taurus_UMD|evm.model.AC_000187.1.1108 O15480 MAGB3_HUMAN 72.662 0.831325 0.479769 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Taurus_UMD|evm.model.AC_000187.1.1109 O15480 MAGB3_HUMAN 77.228 0.20284 1.42486 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Taurus_UMD|evm.model.AC_000187.1.1110 O15480 MAGB3_HUMAN 78.512 0.97561 0.355491 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Taurus_UMD|evm.model.AC_000187.1.1126 O15480 MAGB3_HUMAN 62.539 0.92 1.01156 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Taurus_UMD|evm.model.AC_000187.1.1127 O15479 MAGB2_HUMAN 55.189 0.461707 1.4326 MAGEB2 - Melanoma-associated antigen B2 - Homo sapiens (Human) - MAGEB2 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Taurus_UMD|evm.model.AC_000187.1.1128 Q28029 VATF_BOVIN 82.667 0.936709 0.663866 ATP6V1F - V-type proton ATPase subunit F - Bos taurus (Bovine) - ATP6V1F gene Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Taurus_UMD|evm.model.AC_000187.1.1139 Q9TTY4 MAGBA_CANLF 58.163 0.311005 1.65873 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Taurus_UMD|evm.model.AC_000187.1.1140 O15479 MAGB2_HUMAN 51.012 0.54343 1.40752 MAGEB2 - Melanoma-associated antigen B2 - Homo sapiens (Human) - MAGEB2 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Taurus_UMD|evm.model.AC_000187.1.1141 P43366 MAGB1_HUMAN 45.022 0.838828 0.786744 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Taurus_UMD|evm.model.AC_000187.1.1145 O15481 MAGB4_HUMAN 63.025 0.183801 1.85549 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1147 P59823 IRPL1_MOUSE 82.339 0.915459 0.595683 Il1rapl1 - Interleukin-1 receptor accessory protein-like 1 precursor - Mus musculus (Mouse) - Il1rapl1 gene May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK (By similarity). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (PubMed:25908590, PubMed:21940441). Taurus_UMD|evm.model.AC_000187.1.1148 Q3ZLR7 SP201_HUMAN 56.051 0.412389 1.37303 SUPT20HL1 - Transcription factor SPT20 homolog-like 1 - Homo sapiens (Human) - SUPT20HL1 gene SAGA complex, transcription coregulator activity, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000187.1.1149 Q8NEM7 SP20H_HUMAN 43.662 0.576812 0.442875 SUPT20H - Transcription factor SPT20 homolog - Homo sapiens (Human) - SUPT20H gene Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. Taurus_UMD|evm.model.AC_000187.1.1152 Q9TTY4 MAGBA_CANLF 58.917 0.893983 0.92328 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Taurus_UMD|evm.model.AC_000187.1.1153 Q96LZ2 MAGBA_HUMAN 63.248 0.564165 1.1902 MAGEB10 - Melanoma-associated antigen B10 - Homo sapiens (Human) - MAGEB10 gene Taurus_UMD|evm.model.AC_000187.1.1154 Q9TTY4 MAGBA_CANLF 60.510 0.896848 0.92328 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Taurus_UMD|evm.model.AC_000187.1.1155 Q8N7N5 DCAF8_MOUSE 75.641 0.397933 0.654822 Dcaf8 - DDB1- and CUL4-associated factor 8 - Mus musculus (Mouse) - Dcaf8 gene May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Taurus_UMD|evm.model.AC_000187.1.1156 Q5MIZ7 P4R3B_HUMAN 59.398 0.968952 0.910483 PPP4R3B - Serine/threonine-protein phosphatase 4 regulatory subunit 3B - Homo sapiens (Human) - PPP4R3B gene Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Taurus_UMD|evm.model.AC_000187.1.1157 Q9ULU4 PKCB1_HUMAN 70.000 0.977753 0.75801 ZMYND8 - Protein kinase C-binding protein 1 - Homo sapiens (Human) - ZMYND8 gene May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion. Taurus_UMD|evm.model.AC_000187.1.1158 Q5R7J8 TP4A1_PONAB 55.405 0.982456 0.32948 PTP4A1 - Protein tyrosine phosphatase type IVA 1 precursor - Pongo abelii (Sumatran orangutan) - PTP4A1 gene Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). Taurus_UMD|evm.model.AC_000187.1.1159 Q9BZ81 MAGB5_HUMAN 57.724 0.680556 1.30909 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Taurus_UMD|evm.model.AC_000187.1.1160 O15479 MAGB2_HUMAN 54.494 0.569579 0.968652 MAGEB2 - Melanoma-associated antigen B2 - Homo sapiens (Human) - MAGEB2 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Taurus_UMD|evm.model.AC_000187.1.1161 A2A368 MAGBG_HUMAN 51.852 0.603053 0.808642 MAGEB16 - Melanoma-associated antigen B16 - Homo sapiens (Human) - MAGEB16 gene Taurus_UMD|evm.model.AC_000187.1.1162 Q9BZ81 MAGB5_HUMAN 67.660 0.382979 2.22182 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Taurus_UMD|evm.model.AC_000187.1.1163 O15481 MAGB4_HUMAN 45.015 0.943396 0.919075 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1164 Q9BZ81 MAGB5_HUMAN 68.333 0.792035 0.821818 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Taurus_UMD|evm.model.AC_000187.1.1165 P43366 MAGB1_HUMAN 51.735 0.912791 0.991354 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Taurus_UMD|evm.model.AC_000187.1.1166 O15479 MAGB2_HUMAN 45.455 0.375 0.451411 MAGEB2 - Melanoma-associated antigen B2 - Homo sapiens (Human) - MAGEB2 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Taurus_UMD|evm.model.AC_000187.1.1167 P43366 MAGB1_HUMAN 50.000 0.978261 0.397695 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Taurus_UMD|evm.model.AC_000187.1.1168 A8MXT2 MAGBH_HUMAN 50.732 0.456376 1.33036 MAGEB17 - Melanoma-associated antigen B17 - Homo sapiens (Human) - MAGEB17 gene Taurus_UMD|evm.model.AC_000187.1.1169 Q96M61 MAGBI_HUMAN 69.767 0.328125 0.746356 MAGEB18 - Melanoma-associated antigen B18 - Homo sapiens (Human) - MAGEB18 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Taurus_UMD|evm.model.AC_000187.1.1170 A2A368 MAGBG_HUMAN 72.727 0.233871 1.14815 MAGEB16 - Melanoma-associated antigen B16 - Homo sapiens (Human) - MAGEB16 gene Taurus_UMD|evm.model.AC_000187.1.1171 P43366 MAGB1_HUMAN 45.882 0.767123 0.631124 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Taurus_UMD|evm.model.AC_000187.1.1172 Q9BZ81 MAGB5_HUMAN 70.000 0.806306 0.807273 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Taurus_UMD|evm.model.AC_000187.1.1173 A8MXT2 MAGBH_HUMAN 52.145 0.980328 0.907738 MAGEB17 - Melanoma-associated antigen B17 - Homo sapiens (Human) - MAGEB17 gene Taurus_UMD|evm.model.AC_000187.1.1174 O15480 MAGB3_HUMAN 61.429 0.139676 1.42775 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Taurus_UMD|evm.model.AC_000187.1.1175 Q9BZ81 MAGB5_HUMAN 64.865 0.688213 0.956364 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Taurus_UMD|evm.model.AC_000187.1.1176 P43366 MAGB1_HUMAN 51.582 0.912791 0.991354 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Taurus_UMD|evm.model.AC_000187.1.1177 O15481 MAGB4_HUMAN 46.526 0.896024 0.945087 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1178 O15481 MAGB4_HUMAN 58.730 0.102649 1.74566 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1179 Q9TTY4 MAGBA_CANLF 63.006 0.339921 1.33862 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Taurus_UMD|evm.model.AC_000187.1.1180 O15479 MAGB2_HUMAN 51.020 0.192 0.783699 MAGEB2 - Melanoma-associated antigen B2 - Homo sapiens (Human) - MAGEB2 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Taurus_UMD|evm.model.AC_000187.1.1181 P43366 MAGB1_HUMAN 47.273 0.769953 0.613833 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Taurus_UMD|evm.model.AC_000187.1.1182 Q9BZ81 MAGB5_HUMAN 72.487 0.831858 0.821818 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Taurus_UMD|evm.model.AC_000187.1.1183 Q9BZ81 MAGB5_HUMAN 67.647 0.673295 1.28 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Taurus_UMD|evm.model.AC_000187.1.1184 O15481 MAGB4_HUMAN 52.201 0.920588 0.982659 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1185 O15479 MAGB2_HUMAN 64.348 0.844444 0.423197 MAGEB2 - Melanoma-associated antigen B2 - Homo sapiens (Human) - MAGEB2 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Taurus_UMD|evm.model.AC_000187.1.1186 Q8N7X4 MAGB6_HUMAN 47.059 0.683673 0.240786 MAGEB6 - Melanoma-associated antigen B6 - Homo sapiens (Human) - MAGEB6 gene Taurus_UMD|evm.model.AC_000187.1.1187 Q9BZ81 MAGB5_HUMAN 63.758 0.380463 1.41455 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Taurus_UMD|evm.model.AC_000187.1.1188 P43366 MAGB1_HUMAN 53.165 0.912791 0.991354 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Taurus_UMD|evm.model.AC_000187.1.1189 O15481 MAGB4_HUMAN 75.758 0.970149 0.193642 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1190 A8MXT2 MAGBH_HUMAN 45.882 0.878307 0.5625 MAGEB17 - Melanoma-associated antigen B17 - Homo sapiens (Human) - MAGEB17 gene Taurus_UMD|evm.model.AC_000187.1.1191 P43366 MAGB1_HUMAN 45.122 0.75463 0.622478 MAGEB1 - Melanoma-associated antigen B1 - Homo sapiens (Human) - MAGEB1 gene Taurus_UMD|evm.model.AC_000187.1.1192 Q9BZ81 MAGB5_HUMAN 58.454 0.719858 1.02545 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Taurus_UMD|evm.model.AC_000187.1.1193 A8MXT2 MAGBH_HUMAN 51.273 0.992727 0.818452 MAGEB17 - Melanoma-associated antigen B17 - Homo sapiens (Human) - MAGEB17 gene Taurus_UMD|evm.model.AC_000187.1.1194 A8MXT2 MAGBH_HUMAN 48.571 0.945098 0.758929 MAGEB17 - Melanoma-associated antigen B17 - Homo sapiens (Human) - MAGEB17 gene Taurus_UMD|evm.model.AC_000187.1.1195 Q9BZ81 MAGB5_HUMAN 64.039 0.229025 3.20727 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Taurus_UMD|evm.model.AC_000187.1.1196 Q9BZ81 MAGB5_HUMAN 64.706 0.325744 2.07636 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Taurus_UMD|evm.model.AC_000187.1.1197 Q9TTY4 MAGBA_CANLF 68.182 0.970149 0.177249 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Taurus_UMD|evm.model.AC_000187.1.1198 Q4R998 MAGBI_MACFA 65.517 0.237288 0.343023 MAGEB18 - Melanoma-associated antigen B18 - Macaca fascicularis (Crab-eating macaque) - MAGEB18 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). Taurus_UMD|evm.model.AC_000187.1.1199 A8MXT2 MAGBH_HUMAN 47.196 0.976959 0.645833 MAGEB17 - Melanoma-associated antigen B17 - Homo sapiens (Human) - MAGEB17 gene Taurus_UMD|evm.model.AC_000187.1.1200 O15481 MAGB4_HUMAN 53.354 0.949254 0.968208 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1201 A8MXT2 MAGBH_HUMAN 46.735 0.992509 0.794643 MAGEB17 - Melanoma-associated antigen B17 - Homo sapiens (Human) - MAGEB17 gene Taurus_UMD|evm.model.AC_000187.1.1202 Q96M61 MAGBI_HUMAN 65.815 0.900293 0.994169 MAGEB18 - Melanoma-associated antigen B18 - Homo sapiens (Human) - MAGEB18 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Taurus_UMD|evm.model.AC_000187.1.1203 P54612 2AAA_PIG 82.003 0.99661 1.0017 PPP2R1A - Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform - Sus scrofa (Pig) - PPP2R1A gene The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. Taurus_UMD|evm.model.AC_000187.1.1204 P54612 2AAA_PIG 79.796 0.956098 1.04414 PPP2R1A - Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform - Sus scrofa (Pig) - PPP2R1A gene The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. Taurus_UMD|evm.model.AC_000187.1.1206 A6YP92 ARX_RAT 93.274 0.475162 0.818021 Arx - Homeobox protein ARX - Rattus norvegicus (Rat) - Arx gene Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (By similarity). Taurus_UMD|evm.model.AC_000187.1.1207 P09884 DPOLA_HUMAN 90.123 0.998639 1.00479 POLA1 - DNA polymerase alpha catalytic subunit - Homo sapiens (Human) - POLA1 gene Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227). Taurus_UMD|evm.model.AC_000187.1.1208 Q811Q9 PCY1B_MOUSE 97.019 0.994595 1.00271 Pcyt1b - Choline-phosphate cytidylyltransferase B - Mus musculus (Mouse) - Pcyt1b gene Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis (PubMed:12842190). Plays an important role in ovary maturation and the maintenance of sperm production (PubMed:15143167). Taurus_UMD|evm.model.AC_000187.1.1209 Q15120 PDK3_HUMAN 98.522 0.995086 1.00246 PDK3 - [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial precursor - Homo sapiens (Human) - PDK3 gene Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. Taurus_UMD|evm.model.AC_000187.1.1210 Q66HC7 SP20H_RAT 58.835 0.650558 1.52264 Supt20h - Transcription factor SPT20 homolog - Rattus norvegicus (Rat) - Supt20h gene Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy (By similarity). Taurus_UMD|evm.model.AC_000187.1.1211 P61247 RS3A_HUMAN 98.485 0.992453 1.00379 RPS3A - 40S ribosomal protein S3a - Homo sapiens (Human) - RPS3A gene May play a role during erythropoiesis through regulation of transcription factor DDIT3. Taurus_UMD|evm.model.AC_000187.1.1212 Q7TT00 SP20H_MOUSE 57.744 0.905097 1.07358 Supt20h - Transcription factor SPT20 homolog - Mus musculus (Mouse) - Supt20h gene Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy. Taurus_UMD|evm.model.AC_000187.1.1214 O62836 ZFX_BOVIN 100.000 0.997503 1.00125 ZFX - Zinc finger X-chromosomal protein - Bos taurus (Bovine) - ZFX gene Probable transcriptional activator. Taurus_UMD|evm.model.AC_000187.1.1216 Q2KHU8 IF2G_BOVIN 100.000 0.995772 1.00212 EIF2S3 - Eukaryotic translation initiation factor 2 subunit 3 - Bos taurus (Bovine) - EIF2S3 gene As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). Taurus_UMD|evm.model.AC_000187.1.1217 Q96M94 KLH15_HUMAN 98.510 0.996694 1.00166 KLHL15 - Kelch-like protein 15 - Homo sapiens (Human) - KLHL15 gene Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex (PubMed:14528312). Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits (PubMed:23135275). Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:27561354). Taurus_UMD|evm.model.AC_000187.1.1218 Q96LI9 CX058_HUMAN 63.441 0.790598 0.704819 CXorf58 - Putative uncharacterized protein CXorf58 - Homo sapiens (Human) - CXorf58 gene Taurus_UMD|evm.model.AC_000187.1.1219 Q148H0 MIC26_BOVIN 98.485 0.929245 1.07071 APOO - MICOS complex subunit MIC26 precursor - Bos taurus (Bovine) - APOO gene Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function. Can induce cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts. Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. Taurus_UMD|evm.model.AC_000187.1.1220 Q3T0Q0 SAT1_BOVIN 100.000 0.988372 1.00585 SAT1 - Diamine acetyltransferase 1 - Bos taurus (Bovine) - SAT1 gene Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine. Taurus_UMD|evm.model.AC_000187.1.1221 Q3SWX2 ACOT9_BOVIN 100.000 0.995434 1.00229 ACOT9 - Acyl-coenzyme A thioesterase 9, mitochondrial precursor - Bos taurus (Bovine) - ACOT9 gene Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs. Taurus_UMD|evm.model.AC_000187.1.1222 Q9BGI2 PRDX4_BOVIN 100.000 0.992727 1.00365 PRDX4 - Peroxiredoxin-4 precursor - Bos taurus (Bovine) - PRDX4 gene Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. Taurus_UMD|evm.model.AC_000187.1.1223 Q920A7 AFG31_MOUSE 78.049 0.795122 0.259823 Afg3l1 - AFG3-like protein 1 precursor - Mus musculus (Mouse) - Afg3l1 gene Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Taurus_UMD|evm.model.AC_000187.1.1224 O46415 FRIL_BOVIN 41.477 0.924138 0.828571 FTL - Ferritin light chain - Bos taurus (Bovine) - FTL gene Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Taurus_UMD|evm.model.AC_000187.1.1225 Q96NR3 PTHD1_HUMAN 96.916 0.9978 1.02365 PTCHD1 - Patched domain-containing protein 1 - Homo sapiens (Human) - PTCHD1 gene Required for the development and function of the thalamic reticular nucleus (TRN), a part of the thalamus that is critical for thalamocortical transmission, generation of sleep rhythms, sensorimotor processing and attention. Taurus_UMD|evm.model.AC_000187.1.1226 O15481 MAGB4_HUMAN 54.079 0.947674 0.99422 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1227 Q9NXZ2 DDX43_HUMAN 72.680 0.280523 1.06173 DDX43 - Probable ATP-dependent RNA helicase DDX43 - Homo sapiens (Human) - DDX43 gene RNA binding, RNA helicase activity Taurus_UMD|evm.model.AC_000187.1.1228 Q86TM3 DDX53_HUMAN 54.000 0.709524 0.332805 DDX53 - Probable ATP-dependent RNA helicase DDX53 - Homo sapiens (Human) - DDX53 gene cytosol, intracellular membrane-bounded organelle, nucleolus, nucleoplasm, RNA binding, RNA helicase activity Taurus_UMD|evm.model.AC_000187.1.1229 P70081 H48_CHICK 94.915 0.495726 1.13592 H4-VIII - Histone H4 type VIII - Gallus gallus (Chicken) - H4-VIII gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.AC_000187.1.1231 Q811Q9 PCY1B_MOUSE 91.406 0.77439 0.444444 Pcyt1b - Choline-phosphate cytidylyltransferase B - Mus musculus (Mouse) - Pcyt1b gene Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis (PubMed:12842190). Plays an important role in ovary maturation and the maintenance of sperm production (PubMed:15143167). Taurus_UMD|evm.model.AC_000187.1.1232 Q3MHP3 S10AE_BOVIN 79.808 0.980952 1.00962 S100A14 - Protein S100-A14 - Bos taurus (Bovine) - S100A14 gene Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium (By similarity). Taurus_UMD|evm.model.AC_000187.1.1233 A0A1B0GWH4 HSFX3_HUMAN 46.866 0.932353 1.02102 HSFX3 - Heat shock transcription factor, X-linked member 3 - Homo sapiens (Human) - HSFX3 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.AC_000187.1.1234 P43356 MAGA2_HUMAN 50.000 0.589552 0.426752 MAGEA2 - Melanoma-associated antigen 2 - Homo sapiens (Human) - MAGEA2 gene Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation. Taurus_UMD|evm.model.AC_000187.1.1235 Q4VA55 PWP3B_MOUSE 58.451 0.258242 0.801762 Pwwp3b - PWWP domain-containing DNA repair factor 3B - Mus musculus (Mouse) - Pwwp3b gene Taurus_UMD|evm.model.AC_000187.1.1237 P70669 PHEX_MOUSE 95.547 0.851211 0.385848 Phex - Phosphate-regulating neutral endopeptidase PHEX - Mus musculus (Mouse) - Phex gene Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (By similarity). Cleaves ASARM peptides between Ser and Glu or Asp residues (By similarity). Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:11159866, PubMed:18597632, PubMed:26051469). Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:26051469). Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (By similarity). Taurus_UMD|evm.model.AC_000187.1.1238 P62958 HINT1_BOVIN 98.413 0.984252 1.00794 HINT1 - Histidine triad nucleotide-binding protein 1 - Bos taurus (Bovine) - HINT1 gene Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Taurus_UMD|evm.model.AC_000187.1.1239 P78562 PHEX_HUMAN 84.144 0.882 0.667557 PHEX - Phosphate-regulating neutral endopeptidase PHEX - Homo sapiens (Human) - PHEX gene Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (PubMed:9593714, PubMed:15664000, PubMed:18162525, PubMed:18597632). Cleaves ASARM peptides between Ser and Glu or Asp residues (PubMed:18597632). Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:18597632). Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:18597632, PubMed:18162525). Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (PubMed:12220505). Taurus_UMD|evm.model.AC_000187.1.1240 Q3SZA5 SPSY_BOVIN 95.266 0.993994 0.912329 SMS - Spermine synthase - Bos taurus (Bovine) - SMS gene Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). Taurus_UMD|evm.model.AC_000187.1.1241 O75140 DEPD5_HUMAN 86.486 0.973333 0.0467873 DEPDC5 - GATOR complex protein DEPDC5 - Homo sapiens (Human) - DEPDC5 gene As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. Taurus_UMD|evm.model.AC_000187.1.1242 Q0III2 MBTP2_BOVIN 100.000 0.996132 1.00194 MBTPS2 - Membrane-bound transcription factor site-2 protease - Bos taurus (Bovine) - MBTPS2 gene Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. Taurus_UMD|evm.model.AC_000187.1.1243 Q3ZBD4 SMPX_BOVIN 100.000 0.977011 1.01163 SMPX - Small muscular protein - Bos taurus (Bovine) - SMPX gene Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. Taurus_UMD|evm.model.AC_000187.1.1244 Q8N239 KLH34_HUMAN 88.769 0.992355 1.01553 KLHL34 - Kelch-like protein 34 - Homo sapiens (Human) - KLHL34 gene extracellular space Taurus_UMD|evm.model.AC_000187.1.1245 Q8WXI2 CNKR2_HUMAN 94.498 0.997976 0.955513 CNKSR2 - Connector enhancer of kinase suppressor of ras 2 - Homo sapiens (Human) - CNKSR2 gene May function as an adapter protein or regulator of Ras signaling pathways. Taurus_UMD|evm.model.AC_000187.1.1246 P62845 RS15_RAT 50.000 0.877358 0.731034 Rps15 - 40S ribosomal protein S15 - Rattus norvegicus (Rat) - Rps15 gene cytosolic small ribosomal subunit, nucleoplasm, synapse, RNA binding, structural constituent of ribosome, liver regeneration, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosomal small subunit export from nucleus, rRNA processing Taurus_UMD|evm.model.AC_000187.1.1248 Q76B49 CD63_FELCA 67.797 0.928 1.05042 CD63 - CD63 antigen - Felis catus (Cat) - CD63 gene Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli (By similarity). Taurus_UMD|evm.model.AC_000187.1.1250 Q76LV1 HS90B_BOVIN 85.341 0.99684 0.874309 HSP90AB1 - Heat shock protein HSP 90-beta - Bos taurus (Bovine) - HSP90AB1 gene Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10. Taurus_UMD|evm.model.AC_000187.1.1251 P18654 KS6A3_MOUSE 99.858 0.833729 1.13784 Rps6ka3 - Ribosomal protein S6 kinase alpha-3 - Mus musculus (Mouse) - Rps6ka3 gene Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10856237, PubMed:15109498). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (By similarity). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (By similarity). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (By similarity). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (By similarity). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (By similarity). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (By similarity). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (By similarity). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:14504289). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (PubMed:17785202, PubMed:17906627). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (PubMed:22827337). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (PubMed:22827337). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (By similarity). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (PubMed:15109498). Taurus_UMD|evm.model.AC_000187.1.1252 Q96B97 SH3K1_HUMAN 94.309 0.490982 0.750376 SH3KBP1 - SH3 domain-containing kinase-binding protein 1 - Homo sapiens (Human) - SH3KBP1 gene Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). Taurus_UMD|evm.model.AC_000187.1.1253 Q6ZN16 M3K15_HUMAN 86.897 0.998453 0.984768 MAP3K15 - Mitogen-activated protein kinase kinase kinase 15 - Homo sapiens (Human) - MAP3K15 gene May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis. Taurus_UMD|evm.model.AC_000187.1.1254 A7MB35 ODPA_BOVIN 100.000 0.994885 1.00256 PDHA1 - Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor - Bos taurus (Bovine) - PDHA1 gene The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Taurus_UMD|evm.model.AC_000187.1.1255 P0DKL9 A14EL_HUMAN 58.553 0.986842 1 ARL14EPL - ARL14 effector protein-like - Homo sapiens (Human) - ARL14EPL gene Taurus_UMD|evm.model.AC_000187.1.1256 P0DKL9 A14EL_HUMAN 60.526 0.986842 1 ARL14EPL - ARL14 effector protein-like - Homo sapiens (Human) - ARL14EPL gene Taurus_UMD|evm.model.AC_000187.1.1257 P0DKL9 A14EL_HUMAN 61.333 0.973684 1 ARL14EPL - ARL14 effector protein-like - Homo sapiens (Human) - ARL14EPL gene Taurus_UMD|evm.model.AC_000187.1.1258 P0DKL9 A14EL_HUMAN 45.082 0.89313 0.861842 ARL14EPL - ARL14 effector protein-like - Homo sapiens (Human) - ARL14EPL gene Taurus_UMD|evm.model.AC_000187.1.1259 Q8IZP9 AGRG2_HUMAN 82.664 0.998014 0.990167 ADGRG2 - Adhesion G-protein coupled receptor G2 precursor - Homo sapiens (Human) - ADGRG2 gene Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis. Taurus_UMD|evm.model.AC_000187.1.1260 P46019 KPB2_HUMAN 92.065 0.998344 0.978138 PHKA2 - Phosphorylase b kinase regulatory subunit alpha, liver isoform - Homo sapiens (Human) - PHKA2 gene Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. Taurus_UMD|evm.model.AC_000187.1.1261 O14829 PPE1_HUMAN 75.846 0.99232 0.996937 PPEF1 - Serine/threonine-protein phosphatase with EF-hands 1 - Homo sapiens (Human) - PPEF1 gene May have a role in the recovery or adaptation response of photoreceptors. May have a role in development. Taurus_UMD|evm.model.AC_000187.1.1262 O15537 XLRS1_HUMAN 95.477 0.933962 0.946429 RS1 - Retinoschisin precursor - Homo sapiens (Human) - RS1 gene Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (PubMed:27114531). Required for normal structure and function of the retina (PubMed:19093009). Taurus_UMD|evm.model.AC_000187.1.1263 O76039 CDKL5_HUMAN 97.661 0.997775 0.936458 CDKL5 - Cyclin-dependent kinase-like 5 - Homo sapiens (Human) - CDKL5 gene Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). Taurus_UMD|evm.model.AC_000187.1.1264 Q9UQR0 SCML2_HUMAN 83.534 0.419628 0.844286 SCML2 - Sex comb on midleg-like protein 2 - Homo sapiens (Human) - SCML2 gene Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). Taurus_UMD|evm.model.AC_000187.1.1265 Q8NDZ0 BEND2_HUMAN 40.453 0.533632 1.39549 BEND2 - BEN domain-containing protein 2 - Homo sapiens (Human) - BEND2 gene Taurus_UMD|evm.model.AC_000187.1.1266 Q9UHC7 MKRN1_HUMAN 72.000 0.982759 0.721992 MKRN1 - E3 ubiquitin-protein ligase makorin-1 - Homo sapiens (Human) - MKRN1 gene E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. Taurus_UMD|evm.model.AC_000187.1.1267 P22451 RL5_CHICK 49.057 0.602339 0.575758 RPL5 - 60S ribosomal protein L5 - Gallus gallus (Chicken) - RPL5 gene Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Taurus_UMD|evm.model.AC_000187.1.1268 Q9Y5P3 RAI2_HUMAN 84.340 0.996183 0.988679 RAI2 - Retinoic acid-induced protein 2 - Homo sapiens (Human) - RAI2 gene embryo development ending in birth or egg hatching Taurus_UMD|evm.model.AC_000187.1.1269 Q8N228 SCML4_HUMAN 56.164 0.19726 0.881643 SCML4 - Sex comb on midleg-like protein 4 - Homo sapiens (Human) - SCML4 gene Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). Taurus_UMD|evm.model.AC_000187.1.1270 Q6T4R5 NHS_HUMAN 93.000 0.0672098 0.892187 NHS - Nance-Horan syndrome protein - Homo sapiens (Human) - NHS gene May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. Taurus_UMD|evm.model.AC_000187.1.1271 Q6T4R5 NHS_HUMAN 79.474 0.942708 0.116293 NHS - Nance-Horan syndrome protein - Homo sapiens (Human) - NHS gene May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. Taurus_UMD|evm.model.AC_000187.1.1272 P34826 EF1B_RABIT 57.000 0.534884 0.573333 EEF1B - Elongation factor 1-beta - Oryctolagus cuniculus (Rabbit) - EEF1B gene EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. Taurus_UMD|evm.model.AC_000187.1.1274 P10575 GLRX1_BOVIN 95.283 0.981308 1.00943 GLRX - Glutaredoxin-1 - Bos taurus (Bovine) - GLRX gene Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Taurus_UMD|evm.model.AC_000187.1.1275 Q8NFH8 REPS2_HUMAN 92.391 0.970402 0.716667 REPS2 - RalBP1-associated Eps domain-containing protein 2 - Homo sapiens (Human) - REPS2 gene Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:9422736, PubMed:12771942, PubMed:10393179). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). Taurus_UMD|evm.model.AC_000187.1.1276 Q8NFH8 REPS2_HUMAN 84.444 0.25731 0.259091 REPS2 - RalBP1-associated Eps domain-containing protein 2 - Homo sapiens (Human) - REPS2 gene Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:9422736, PubMed:12771942, PubMed:10393179). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). Taurus_UMD|evm.model.AC_000187.1.1277 Q3SWX8 RBBP7_BOVIN 100.000 0.995305 1.00235 RBBP7 - Histone-binding protein RBBP7 - Bos taurus (Bovine) - RBBP7 gene Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity). Taurus_UMD|evm.model.AC_000187.1.1278 Q9NUQ3 TXLNG_HUMAN 86.064 0.996101 0.971591 TXLNG - Gamma-taxilin - Homo sapiens (Human) - TXLNG gene May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. Taurus_UMD|evm.model.AC_000187.1.1279 Q96A49 SYAP1_HUMAN 86.313 0.994429 1.01989 SYAP1 - Synapse-associated protein 1 - Homo sapiens (Human) - SYAP1 gene Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). Taurus_UMD|evm.model.AC_000187.1.1280 Q1RMS2 PYRG2_BOVIN 94.198 0.803779 1.17406 CTPS2 - CTP synthase 2 - Bos taurus (Bovine) - CTPS2 gene Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). Taurus_UMD|evm.model.AC_000187.1.1281 O95147 DUS14_HUMAN 47.143 0.428571 0.813131 DUSP14 - Dual specificity protein phosphatase 14 - Homo sapiens (Human) - DUSP14 gene Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases. Taurus_UMD|evm.model.AC_000187.1.1282 O75529 TAF5L_HUMAN 77.446 0.996672 1.02037 TAF5L - TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L - Homo sapiens (Human) - TAF5L gene Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By similarity). Taurus_UMD|evm.model.AC_000187.1.1283 P30550 GRPR_HUMAN 92.969 0.994805 1.0026 GRPR - Gastrin-releasing peptide receptor - Homo sapiens (Human) - GRPR gene Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By similarity). Taurus_UMD|evm.model.AC_000187.1.1284 Q9Y2D0 CAH5B_HUMAN 86.364 0.783133 0.26183 CA5B - Carbonic anhydrase 5B, mitochondrial precursor - Homo sapiens (Human) - CA5B gene Reversible hydration of carbon dioxide. Taurus_UMD|evm.model.AC_000187.1.1285 Q9DB50 AP1S2_MOUSE 100.000 0.507987 1.95625 Ap1s2 - AP-1 complex subunit sigma-2 - Mus musculus (Mouse) - Ap1s2 gene Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity). Taurus_UMD|evm.model.AC_000187.1.1286 Q15696 U2AFM_HUMAN 86.824 0.904051 0.973029 ZRSR2 - U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 - Homo sapiens (Human) - ZRSR2 gene Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. Taurus_UMD|evm.model.AC_000187.1.1287 Q9Y2D0 CAH5B_HUMAN 90.536 0.993711 1.00315 CA5B - Carbonic anhydrase 5B, mitochondrial precursor - Homo sapiens (Human) - CA5B gene Reversible hydration of carbon dioxide. Taurus_UMD|evm.model.AC_000187.1.1288 Q96KW2 P12L2_HUMAN 44.737 0.792308 0.125604 POM121L2 - POM121-like protein 2 - Homo sapiens (Human) - POM121L2 gene nuclear pore, nuclear localization sequence binding, structural constituent of nuclear pore, protein import into nucleus, RNA export from nucleus Taurus_UMD|evm.model.AC_000187.1.1289 Q0VCT4 CLTRN_BOVIN 100.000 0.640167 1.07658 CLTRN - Collectrin precursor - Bos taurus (Bovine) - CLTRN gene Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity (By similarity). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (By similarity). Regulator of SNARE complex function (By similarity). Stimulator of beta cell replication (By similarity). Taurus_UMD|evm.model.AC_000187.1.1290 Q58DD0 ACE2_BOVIN 99.741 0.948276 1.00995 ACE2 - Angiotensin-converting enzyme 2 precursor - Bos taurus (Bovine) - ACE2 gene Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity. Taurus_UMD|evm.model.AC_000187.1.1291 P97504 BMX_MOUSE 89.399 0.873961 1.10906 Bmx - Cytoplasmic tyrosine-protein kinase BMX - Mus musculus (Mouse) - Bmx gene Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. Taurus_UMD|evm.model.AC_000187.1.1292 O00625 PIR_HUMAN 80.208 0.988142 0.872414 PIR - Pirin - Homo sapiens (Human) - PIR gene Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). Taurus_UMD|evm.model.AC_000187.1.1293 O43915 VEGFD_HUMAN 86.550 0.994169 0.968927 VEGFD - Vascular endothelial growth factor D precursor - Homo sapiens (Human) - VEGFD gene Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Taurus_UMD|evm.model.AC_000187.1.1294 P37287 PIGA_HUMAN 92.990 0.995885 1.00413 PIGA - Phosphatidylinositol N-acetylglucosaminyltransferase subunit A - Homo sapiens (Human) - PIGA gene Catalytic subunit of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. Taurus_UMD|evm.model.AC_000187.1.1295 Q3SZE4 ASB11_BOVIN 99.336 0.958466 0.96904 ASB11 - Ankyrin repeat and SOCS box protein 11 - Bos taurus (Bovine) - ASB11 gene May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Taurus_UMD|evm.model.AC_000187.1.1296 Q96DX5 ASB9_HUMAN 75.510 0.993056 0.979592 ASB9 - Ankyrin repeat and SOCS box protein 9 - Homo sapiens (Human) - ASB9 gene Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A. Taurus_UMD|evm.model.AC_000187.1.1297 Q8NHP6 MSPD2_HUMAN 89.684 0.96146 0.951737 MOSPD2 - Motile sperm domain-containing protein 2 - Homo sapiens (Human) - MOSPD2 gene Endoplasmic reticulum-anchored receptor which modulates interorganelle contacts by interacting with other organelle-bound proteins via their FFAT motif (PubMed:29858488). Might have a more important role in endoplasmic reticulum and endosomes contacts (PubMed:29858488). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892). Taurus_UMD|evm.model.AC_000187.1.1298 Q8NB91 FANCB_HUMAN 68.421 0.997616 0.976717 FANCB - Fanconi anemia group B protein - Homo sapiens (Human) - FANCB gene DNA repair protein required for FANCD2 ubiquitination. Taurus_UMD|evm.model.AC_000187.1.1300 Q7TNC8 GLRA2_MOUSE 98.898 0.994505 0.80531 Glra2 - Glycine receptor subunit alpha-2 precursor - Mus musculus (Mouse) - Glra2 gene Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Plays a role in cellular responses to ethanol. Taurus_UMD|evm.model.AC_000187.1.1301 Q1LZ79 GEMI8_BOVIN 100.000 0.991489 1.00427 GEMIN8 - Gem-associated protein 8 - Bos taurus (Bovine) - GEMIN8 gene The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity). Taurus_UMD|evm.model.AC_000187.1.1302 Q13491 GPM6B_HUMAN 93.411 0.889273 1.09057 GPM6B - Neuronal membrane glycoprotein M6-b - Homo sapiens (Human) - GPM6B gene May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. Taurus_UMD|evm.model.AC_000187.1.1303 O75665 OFD1_HUMAN 70.681 0.998008 0.992095 OFD1 - Oral-facial-digital syndrome 1 protein - Homo sapiens (Human) - OFD1 gene Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). Taurus_UMD|evm.model.AC_000187.1.1304 F1SRI0 TPPC2_PIG 92.715 0.986842 1.08571 TRAPPC2 - Trafficking protein particle complex subunit 2 - Sus scrofa (Pig) - TRAPPC2 gene Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). Taurus_UMD|evm.model.AC_000187.1.1305 P51151 RAB9A_HUMAN 97.512 0.980392 1.01493 RAB9A - Ras-related protein Rab-9A - Homo sapiens (Human) - RAB9A gene Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Taurus_UMD|evm.model.AC_000187.1.1306 Q8N8B7 TEANC_HUMAN 68.750 0.926121 1.07977 TCEANC - Transcription elongation factor A N-terminal and central domain-containing protein - Homo sapiens (Human) - TCEANC gene Taurus_UMD|evm.model.AC_000187.1.1307 Q8IUX8 EGFL6_HUMAN 64.819 0.535977 1.23146 EGFL6 - Epidermal growth factor-like protein 6 precursor - Homo sapiens (Human) - EGFL6 gene May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity). Taurus_UMD|evm.model.AC_000187.1.1308 Q96M61 MAGBI_HUMAN 64.103 0.16309 0.6793 MAGEB18 - Melanoma-associated antigen B18 - Homo sapiens (Human) - MAGEB18 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Taurus_UMD|evm.model.AC_000187.1.1309 Q9TTY4 MAGBA_CANLF 69.811 0.475904 0.878307 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Taurus_UMD|evm.model.AC_000187.1.1310 O15481 MAGB4_HUMAN 71.429 0.72381 0.303468 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1311 P02817 AMELX_BOVIN 100.000 0.97235 1.01878 AMELX - Amelogenin, X isoform precursor - Bos taurus (Bovine) - AMELX gene Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. Taurus_UMD|evm.model.AC_000187.1.1312 O43182 RHG06_HUMAN 85.204 0.997449 0.804928 ARHGAP6 - Rho GTPase-activating protein 6 - Homo sapiens (Human) - ARHGAP6 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. Taurus_UMD|evm.model.AC_000187.1.1313 A5PJG7 CCHL_BOVIN 100.000 0.992754 1.00364 HCCS - Holocytochrome c-type synthase - Bos taurus (Bovine) - HCCS gene Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome. Taurus_UMD|evm.model.AC_000187.1.1315 Q9JJZ5 EGFL6_MOUSE 82.857 0.482517 0.26 Egfl6 - Epidermal growth factor-like protein 6 precursor - Mus musculus (Mouse) - Egfl6 gene May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly. Taurus_UMD|evm.model.AC_000187.1.1316 O15481 MAGB4_HUMAN 57.708 0.444643 1.6185 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1317 Q96M61 MAGBI_HUMAN 64.103 0.142857 0.77551 MAGEB18 - Melanoma-associated antigen B18 - Homo sapiens (Human) - MAGEB18 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Taurus_UMD|evm.model.AC_000187.1.1318 Q96M61 MAGBI_HUMAN 61.538 0.11875 0.932945 MAGEB18 - Melanoma-associated antigen B18 - Homo sapiens (Human) - MAGEB18 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Taurus_UMD|evm.model.AC_000187.1.1319 O15480 MAGB3_HUMAN 72.321 0.15374 2.08671 MAGEB3 - Melanoma-associated antigen B3 - Homo sapiens (Human) - MAGEB3 gene Taurus_UMD|evm.model.AC_000187.1.1320 O15481 MAGB4_HUMAN 72.727 0.628099 0.349711 MAGEB4 - Melanoma-associated antigen B4 - Homo sapiens (Human) - MAGEB4 gene Taurus_UMD|evm.model.AC_000187.1.1321 Q9BZ81 MAGB5_HUMAN 68.487 0.669492 1.28727 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Taurus_UMD|evm.model.AC_000187.1.1322 Q96M61 MAGBI_HUMAN 72.464 0.647619 0.306122 MAGEB18 - Melanoma-associated antigen B18 - Homo sapiens (Human) - MAGEB18 gene May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Taurus_UMD|evm.model.AC_000187.1.1324 O43930 PRKY_HUMAN 87.671 0.705502 1.11552 PRKY - Putative serine/threonine-protein kinase PRKY - Homo sapiens (Human) - PRKY gene cAMP-dependent protein kinase complex, cAMP-dependent protein kinase activity, protein serine/threonine kinase activity, peptidyl-serine phosphorylation, protein phosphorylation, signal transduction Taurus_UMD|evm.model.AC_000187.1.1326 Q9NR99 MXRA5_HUMAN 68.976 0.988842 1.01414 MXRA5 - Matrix-remodeling-associated protein 5 precursor - Homo sapiens (Human) - MXRA5 gene In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli. Taurus_UMD|evm.model.AC_000187.1.1327 Q32KH8 ARSH_CANLF 85.345 0.709877 0.288256 ARSH - Arylsulfatase H - Canis lupus familiaris (Dog) - ARSH gene arylsulfatase activity Taurus_UMD|evm.model.AC_000187.1.1328 Q32KH8 ARSH_CANLF 84.698 0.938127 1.06406 ARSH - Arylsulfatase H - Canis lupus familiaris (Dog) - ARSH gene arylsulfatase activity Taurus_UMD|evm.model.AC_000187.1.1329 P51690 ARSL_HUMAN 75.254 0.996593 0.996604 ARSL - Arylsulfatase L precursor - Homo sapiens (Human) - ARSL gene May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates. Taurus_UMD|evm.model.AC_000187.1.1330 P51689 ARSD_HUMAN 79.191 0.858209 0.677909 ARSD - Arylsulfatase D precursor - Homo sapiens (Human) - ARSD gene endoplasmic reticulum lumen, arylsulfatase activity Taurus_UMD|evm.model.AC_000187.1.1331 P51689 ARSD_HUMAN 84.706 0.792453 0.178752 ARSD - Arylsulfatase D precursor - Homo sapiens (Human) - ARSD gene endoplasmic reticulum lumen, arylsulfatase activity Taurus_UMD|evm.model.AC_000187.1.1333 Q9BZ81 MAGB5_HUMAN 71.622 0.563218 0.949091 MAGEB5 - Melanoma-associated antigen B5 - Homo sapiens (Human) - MAGEB5 gene Taurus_UMD|evm.model.AC_000187.1.1334 Q9TTY4 MAGBA_CANLF 67.647 0.638095 0.277778 MAGEB10 - Melanoma-associated antigen B10 - Canis lupus familiaris (Dog) - MAGEB10 gene Taurus_UMD|evm.model.AC_000187.1.1335 Q9GMV6 TEANC_MACFA 64.478 0.937677 1.00857 TCEANC - Transcription elongation factor A N-terminal and central domain-containing protein - Macaca fascicularis (Crab-eating macaque) - TCEANC gene Taurus_UMD|evm.model.AC_000187.1.1336 O15344 TRI18_HUMAN 98.801 0.997006 1.0015 MID1 - E3 ubiquitin-protein ligase Midline-1 - Homo sapiens (Human) - MID1 gene Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. Taurus_UMD|evm.model.AC_000187.1.1338 P51689 ARSD_HUMAN 68.595 0.857143 0.236088 ARSD - Arylsulfatase D precursor - Homo sapiens (Human) - ARSD gene endoplasmic reticulum lumen, arylsulfatase activity Taurus_UMD|evm.model.AC_000187.1.1339 O15488 GLYG2_HUMAN 67.516 0.45 2.03593 GYG2 - Glycogenin-2 - Homo sapiens (Human) - GYG2 gene Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. Taurus_UMD|evm.model.AC_000187.1.1340 O96006 ZBED1_HUMAN 81.205 0.997135 1.00576 ZBED1 - E3 SUMO-protein ligase ZBED1 - Homo sapiens (Human) - ZBED1 gene Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA (PubMed:27068747). This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12 (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747). The resulting increased transcriptional activity drives cell proliferation (PubMed:12663651, PubMed:17220279). Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747). Taurus_UMD|evm.model.AC_000187.1.1341 Q8N5I4 DHRSX_HUMAN 75.000 0.480916 0.39697 DHRSX - Dehydrogenase/reductase SDR family member on chromosome X - Homo sapiens (Human) - DHRSX gene Involved in the positive regulation of starvation-induced autophagy (PubMed:25076851). Taurus_UMD|evm.model.AC_000187.1.1343 Q8N5I4 DHRSX_HUMAN 74.219 0.725714 0.530303 DHRSX - Dehydrogenase/reductase SDR family member on chromosome X - Homo sapiens (Human) - DHRSX gene Involved in the positive regulation of starvation-induced autophagy (PubMed:25076851). Taurus_UMD|evm.model.AC_000187.1.1344 Q8N8B7 TEANC_HUMAN 66.382 0.925926 1.07692 TCEANC - Transcription elongation factor A N-terminal and central domain-containing protein - Homo sapiens (Human) - TCEANC gene Taurus_UMD|evm.model.AC_000187.1.1345 Q2HJ51 RA51D_BOVIN 51.682 0.987288 0.723926 RAD51D - DNA repair protein RAD51 homolog 4 - Bos taurus (Bovine) - RAD51D gene Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM (By similarity). Taurus_UMD|evm.model.AC_000187.1.1348 Q9NR97 TLR8_HUMAN 73.821 0.998066 0.993276 TLR8 - Toll-like receptor 8 precursor - Homo sapiens (Human) - TLR8 gene Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653). Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses (PubMed:33718825). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371, PubMed:33718825). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428). Taurus_UMD|evm.model.AC_000187.1.1349 Q9NYK1 TLR7_HUMAN 86.476 0.998097 1.00191 TLR7 - Toll-like receptor 7 precursor - Homo sapiens (Human) - TLR7 gene Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:31608988, PubMed:27742543, PubMed:12738885, PubMed:32706371). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:27742543, PubMed:32706371). Taurus_UMD|evm.model.AC_000187.1.1350 P09330 PRPS2_RAT 99.020 0.990244 0.644654 Prps2 - Ribose-phosphate pyrophosphokinase 2 - Rattus norvegicus (Rat) - Prps2 gene Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Taurus_UMD|evm.model.AC_000187.1.1351 Q5R8F8 PRPS2_PONAB 99.020 0.691781 0.459119 PRPS2 - Ribose-phosphate pyrophosphokinase 2 - Pongo abelii (Sumatran orangutan) - PRPS2 gene Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Taurus_UMD|evm.model.AC_000187.1.1352 Q14CM0 FRPD4_HUMAN 90.465 0.741087 1.29425 FRMPD4 - FERM and PDZ domain-containing protein 4 - Homo sapiens (Human) - FRMPD4 gene Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate. Taurus_UMD|evm.model.AC_000187.1.1354 Q8N5Y2 MS3L1_HUMAN 94.626 0.996161 1 MSL3 - Male-specific lethal 3 homolog - Homo sapiens (Human) - MSL3 gene Has a role in chromatin remodeling and transcriptional regulation (PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647). Has a role in X inactivation (PubMed:21217699). Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure (PubMed:16227571, PubMed:20657587, PubMed:16543150, PubMed:30224647). Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). Taurus_UMD|evm.model.AC_000187.1.1355 O43182 RHG06_HUMAN 85.714 0.901408 0.218686 ARHGAP6 - Rho GTPase-activating protein 6 - Homo sapiens (Human) - ARHGAP6 gene GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. Taurus_UMD|evm.model.AC_000187.1.1356 P49840 GSK3A_HUMAN 79.070 0.653846 0.269151 GSK3A - Glycogen synthase kinase-3 alpha - Homo sapiens (Human) - GSK3A gene Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350). Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, leading to activate KAT5/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Taurus_UMD|evm.model.AC_000187.1.1357 Q93008 USP9X_HUMAN 94.648 0.994077 0.396633 USP9X - Probable ubiquitin carboxyl-terminal hydrolase FAF-X - Homo sapiens (Human) - USP9X gene Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration (PubMed:16322459, PubMed:18254724, PubMed:19135894, PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity (PubMed:29626158). Taurus_UMD|evm.model.AC_000187.1.1358 Q15696 U2AFM_HUMAN 78.641 0.905077 0.939834 ZRSR2 - U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 - Homo sapiens (Human) - ZRSR2 gene Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. Taurus_UMD|evm.model.AC_000187.1.1359 O15550 KDM6A_HUMAN 79.772 0.620253 0.902213 KDM6A - Lysine-specific demethylase 6A - Homo sapiens (Human) - KDM6A gene Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). Taurus_UMD|evm.model.AC_000187.1.1360 Q5RF43 DDX3Y_PONAB 88.654 0.996979 1.00608 DDX3Y - ATP-dependent RNA helicase DDX3Y - Pongo abelii (Sumatran orangutan) - DDX3Y gene Probable ATP-dependent RNA helicase. May play a role in spermatogenesis (By similarity). Taurus_UMD|evm.model.AC_000187.1.1361 Q9NUJ7 PLCX1_HUMAN 59.813 0.987461 0.987616 PLCXD1 - PI-PLC X domain-containing protein 1 - Homo sapiens (Human) - PLCXD1 gene Taurus_UMD|evm.model.AC_000187.1.1362 Q96EQ9 PRDM9_MOUSE 74.434 0.220157 1.65955 Prdm9 - Histone-lysine N-methyltransferase PRDM9 - Mus musculus (Mouse) - Prdm9 gene Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:16292313, PubMed:24095733, PubMed:27362481, PubMed:24785241, PubMed:29478809). Also can methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24785241, PubMed:27362481). Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (PubMed:24785241, PubMed:27362481). During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:22028627, PubMed:27362481, PubMed:29478809). Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (PubMed:16292313, PubMed:29478809). During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema (PubMed:27932493). EWSR1 joins PRDM9 with the chromosomal axis through REC8 (PubMed:27932493). In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (PubMed:25894966, PubMed:16292313). Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (PubMed:16292313). In addition performs automethylation (PubMed:28126738). Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (PubMed:27362481). Taurus_UMD|evm.model.AC_000187.1.1363 Q13796 SHRM2_HUMAN 43.218 0.853982 0.559406 SHROOM2 - Protein Shroom2 - Homo sapiens (Human) - SHROOM2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). Taurus_UMD|evm.model.AC_000187.1.1364 Q13796 SHRM2_HUMAN 86.667 0.962366 0.115099 SHROOM2 - Protein Shroom2 - Homo sapiens (Human) - SHROOM2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). Taurus_UMD|evm.model.AC_000187.1.1365 A2ALU4 SHRM2_MOUSE 75.681 0.753623 0.419311 Shroom2 - Protein Shroom2 - Mus musculus (Mouse) - Shroom2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution. Taurus_UMD|evm.model.AC_000187.1.1366 P51810 GP143_HUMAN 77.723 0.97343 1.02475 GPR143 - G-protein coupled receptor 143 - Homo sapiens (Human) - GPR143 gene Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. Taurus_UMD|evm.model.AC_000187.1.1367 Q13796 SHRM2_HUMAN 55.868 0.949275 0.597772 SHROOM2 - Protein Shroom2 - Homo sapiens (Human) - SHROOM2 gene May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). Taurus_UMD|evm.model.AC_000187.1.1369 P81795 IF2G_RAT 97.650 0.985232 1.00424 Eif2s3 - Eukaryotic translation initiation factor 2 subunit 3, X-linked - Rattus norvegicus (Rat) - Eif2s3 gene As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). Taurus_UMD|evm.model.AC_000187.1.1372 Q9QXE7 TBL1X_MOUSE 97.727 0.996219 1.0038 Tbl1x - F-box-like/WD repeat-containing protein TBL1X - Mus musculus (Mouse) - Tbl1x gene F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity). Taurus_UMD|evm.model.AC_000187.1.1375 P23352 KALM_HUMAN 82.138 0.997054 0.998529 ANOS1 - Anosmin-1 precursor - Homo sapiens (Human) - ANOS1 gene Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells. Taurus_UMD|evm.model.AC_000187.1.1383 P41247 PLPL4_HUMAN 84.672 0.410876 1.3083 PNPLA4 - Patatin-like phospholipase domain-containing protein 4 - Homo sapiens (Human) - PNPLA4 gene Has abundant triacylglycerol lipase activity (PubMed:15364929). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Taurus_UMD|evm.model.AC_000187.1.1385 P08842 STS_HUMAN 71.404 0.994444 0.926244 STS - Steryl-sulfatase precursor - Homo sapiens (Human) - STS gene Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. Taurus_UMD|evm.model.AC_000187.1.1387 Q08623 HDHD1_HUMAN 80.519 0.991379 1.01754 PUDP - Pseudouridine-5'-phosphatase - Homo sapiens (Human) - PUDP gene Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine. Taurus_UMD|evm.model.AC_000187.1.1388 Q8N0W4 NLGNX_HUMAN 98.187 0.966276 0.835784 NLGN4X - Neuroligin-4, X-linked precursor - Homo sapiens (Human) - NLGN4X gene Putative neuronal cell surface protein involved in cell-cell-interactions. Taurus_UMD|evm.model.AC_000187.1.1390 Q28133 ALL2_BOVIN 96.045 0.466844 2.19186 Allergen Bos d 2 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000187.1.1391 Q28133 ALL2_BOVIN 60.563 0.182796 2.16279 Allergen Bos d 2 precursor - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000187.1.1392 P07435 OBP_BOVIN 33.766 0.734568 1.01887 Odorant-binding protein - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000187.1.1394 P07435 OBP_BOVIN 52.151 0.728346 1.59748 Odorant-binding protein - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000187.1.1395 P81245 OBP_PIG 52.941 0.0971014 4.3949 Odorant-binding protein - Sus scrofa (Pig) Taurus_UMD|evm.model.AC_000187.1.1396 P07435 OBP_BOVIN 98.026 0.639831 1.48428 Odorant-binding protein - Bos taurus (Bovine) Taurus_UMD|evm.model.AC_000187.1.1397 Q02040 AK17A_HUMAN 93.782 0.964824 0.286331 AKAP17A - A-kinase anchor protein 17A - Homo sapiens (Human) - AKAP17A gene Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. Taurus_UMD|evm.model.AC_000187.1.1398 Q86VZ1 P2RY8_HUMAN 79.494 0.367261 2.6546 P2RY8 - P2Y purinoceptor 8 - Homo sapiens (Human) - P2RY8 gene Probable receptor for purines coupled to G-proteins. Taurus_UMD|evm.model.AC_000187.1.1399 O95671 ASML_HUMAN 82.278 0.847826 0.148148 ASMTL - Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein - Homo sapiens (Human) - ASMTL gene Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). Taurus_UMD|evm.model.NC_006853.1.1 P03910 NU4M_BOVIN 94.074 0.985294 0.296296 MT-ND4 - NADH-ubiquinone oxidoreductase chain 4 - Bos taurus (Bovine) - MT-ND4 gene Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. Taurus_UMD|evm.model.NW_003097938.1.1 P96119 TROD_TREPA 36.232 0.703072 0.798365 troD - Zinc transport system membrane protein TroD - Treponema pallidum (strain Nichols) - troD gene Part of an ATP-driven transport system TroABCD for zinc. Taurus_UMD|evm.model.NW_003097939.1.2 Q9SSA7 GLIP5_ARATH 27.667 0.912088 0.709091 GLIP5 - GDSL esterase/lipase 5 precursor - Arabidopsis thaliana (Mouse-ear cress) - GLIP5 gene lipase activity Taurus_UMD|evm.model.NW_003097947.1.1 Q6F0U4 NADE_MESFL 40.594 0.510204 0.803279 nadE - NH(3)-dependent NAD(+) synthetase - Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1) - nadE gene Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. Taurus_UMD|evm.model.NW_003097967.1.1 Q61333 TNAP2_MOUSE 71.654 0.807692 0.22576 Tnfaip2 - Tumor necrosis factor alpha-induced protein 2 - Mus musculus (Mouse) - Tnfaip2 gene May play a role as a mediator of inflammation and angiogenesis. Taurus_UMD|evm.model.NW_003097978.1.1 Q5UP06 YR756_MIMIV 33.908 0.936047 0.577181 MIMI_R756 - Uncharacterized protein R756 - Acanthamoeba polyphaga mimivirus (APMV) - MIMI_R756 gene Taurus_UMD|evm.model.NW_003098181.1.1 O02751 CFDP2_BOVIN 48.052 0.374359 0.329392 CFDP2 - Craniofacial development protein 2 - Bos taurus (Bovine) - CFDP2 gene Taurus_UMD|evm.model.NW_003098529.1.2 Q7BSM9 IMPA_SHIFL 48.889 0.577922 1.06207 impA - Protein ImpA - Shigella flexneri - impA gene Involved in UV protection and mutation. Taurus_UMD|evm.model.NW_003098666.1.1 O15439 MRP4_HUMAN 86.667 0.951613 0.0467925 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.NW_003098795.1.1 P31424 GRM5_RAT 65.359 0.863636 0.146301 Grm5 - Metabotropic glutamate receptor 5 precursor - Rattus norvegicus (Rat) - Grm5 gene G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. Taurus_UMD|evm.model.NW_003099167.1.1 Q9NQV7 PRDM9_HUMAN 65.397 0.980738 0.696868 PRDM9 - Histone-lysine N-methyltransferase PRDM9 - Homo sapiens (Human) - PRDM9 gene Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:24634223, PubMed:24095733, PubMed:26833727). Also can methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24095733, PubMed:24634223, PubMed:26833727). Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (By similarity). During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:26833727). Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (By similarity). During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema. EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity). In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (By similarity). Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (By similarity). In addition performs automethylation (By similarity). Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (By similarity). Taurus_UMD|evm.model.NW_003099167.1.2 Q8NGP3 OR5M9_HUMAN 68.539 0.99359 0.503226 OR5M9 - Olfactory receptor 5M9 - Homo sapiens (Human) - OR5M9 gene Odorant receptor. Taurus_UMD|evm.model.NW_003099167.1.3 Q1W6H9 F110C_HUMAN 67.638 0.830946 1.08723 FAM110C - Protein FAM110C - Homo sapiens (Human) - FAM110C gene May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway. Taurus_UMD|evm.model.NW_003099169.1.1 Q3SZ01 SH3Y1_BOVIN 99.187 0.938697 0.765396 SH3YL1 - SH3 domain-containing YSC84-like protein 1 - Bos taurus (Bovine) - SH3YL1 gene ruffle membrane, phosphatidylinositol binding Taurus_UMD|evm.model.NW_003099170.1.1 Q3SZ01 SH3Y1_BOVIN 100.000 0.366412 0.768328 SH3YL1 - SH3 domain-containing YSC84-like protein 1 - Bos taurus (Bovine) - SH3YL1 gene ruffle membrane, phosphatidylinositol binding Taurus_UMD|evm.model.NW_003099170.1.2 P24666 PPAC_HUMAN 89.873 0.987421 1.00633 ACP1 - Low molecular weight phosphotyrosine protein phosphatase - Homo sapiens (Human) - ACP1 gene Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity. Taurus_UMD|evm.model.NW_003099170.1.3 B2RZ42 ALKL2_RAT 80.556 0.33758 2.07947 Alkal2 - ALK and LTK ligand 2 precursor - Rattus norvegicus (Rat) - Alkal2 gene Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation. Taurus_UMD|evm.model.NW_003099175.1.3 Q3SZ36 TMM18_BOVIN 100.000 0.985714 1.00719 TMEM18 - Transmembrane protein 18 - Bos taurus (Bovine) - TMEM18 gene Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC) (By similarity). Taurus_UMD|evm.model.NW_003099179.1.1 Q9NY99 SNTG2_HUMAN 62.353 0.674419 0.877551 SNTG2 - Gamma-2-syntrophin - Homo sapiens (Human) - SNTG2 gene Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). Taurus_UMD|evm.model.NW_003099180.1.1 Q92626 PXDN_HUMAN 87.823 0.992547 0.997972 PXDN - Peroxidasin homolog precursor - Homo sapiens (Human) - PXDN gene Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation. Taurus_UMD|evm.model.NW_003099183.1.1 P70475 MYT1L_RAT 98.000 0.376923 0.10952 Myt1l - Myelin transcription factor 1-like protein - Rattus norvegicus (Rat) - Myt1l gene Transcription factor that plays a key role in neuronal differentiation (PubMed:9373037). Acts by specifically repressing expression of non-neuronal genes during neuron differentiation (By similarity). In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (By similarity). Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B (By similarity). The 5'-AAGTT-3' core motif is absent from the promoter of neural genes (By similarity). Taurus_UMD|evm.model.NW_003099192.1.1 O19110 TSPY1_BOVIN 82.051 0.308943 0.388013 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.NW_003099192.1.3 O19110 TSPY1_BOVIN 53.723 0.988235 0.536278 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.NW_003099450.1.1 O15439 MRP4_HUMAN 88.462 0.980769 0.0392453 ABCC4 - ATP-binding cassette sub-family C member 4 - Homo sapiens (Human) - ABCC4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). Taurus_UMD|evm.model.NW_003099453.1.1 Q02817 MUC2_HUMAN 90.588 0.12943 0.125314 MUC2 - Mucin-2 precursor - Homo sapiens (Human) - MUC2 gene Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. Taurus_UMD|evm.model.NW_003099969.1.1 P84057 H2A_TIGCA 99.187 0.976 1.00806 His2A - Histone H2A - Tigriopus californicus (Marine copepod) - His2A gene Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Taurus_UMD|evm.model.NW_003099970.1.1 P40264 H12_GLYBA 81.081 0.265683 1.1681 Histone H1-II - Glyptotendipes barbipes (Midge) Taurus_UMD|evm.model.NW_003099972.1.1 P0CT39 TF26_SCHPO 24.096 0.900585 0.128282 Tf2-6 - Transposon Tf2-6 polyprotein - Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) - Tf2-6 gene RNA-directed DNA polymerase activity Taurus_UMD|evm.model.NW_003100065.1.2 P01857 IGHG1_HUMAN 70.000 0.993289 0.90303 IGHG1 - Immunoglobulin heavy constant gamma 1 - Homo sapiens (Human) - IGHG1 gene Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Taurus_UMD|evm.model.NW_003100068.1.1 Q80Z19 MUC2_MOUSE 73.890 0.612653 0.336194 Muc2 - Mucin-2 precursor - Mus musculus (Mouse) - Muc2 gene Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. Taurus_UMD|evm.model.NW_003100079.1.1 P98084 APBA2_MOUSE 53.947 0.814815 0.108 Apba2 - Amyloid-beta A4 precursor protein-binding family A member 2 - Mus musculus (Mouse) - Apba2 gene Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Taurus_UMD|evm.model.NW_003100083.1.1 E9Q236 MRP4_MOUSE 68.831 0.987013 0.0581132 Abcc4 - ATP-binding cassette sub-family C member 4 - Mus musculus (Mouse) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Taurus_UMD|evm.model.NW_003100114.1.1 P10950 ASMT_BOVIN 69.863 0.717172 0.286957 ASMT - Acetylserotonin O-methyltransferase - Bos taurus (Bovine) - ASMT gene Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Taurus_UMD|evm.model.NW_003100248.1.1 A5PKB7 GIMA6_BOVIN 72.249 0.97619 0.615836 GIMAP6 - GTPase IMAP family member 6 - Bos taurus (Bovine) - GIMAP6 gene cytosol Taurus_UMD|evm.model.NW_003100254.1.1 Q9UKM7 MA1B1_HUMAN 82.468 0.987097 0.221745 MAN1B1 - Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase - Homo sapiens (Human) - MAN1B1 gene Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). Taurus_UMD|evm.model.NW_003100254.1.2 Q9ET22 DPP2_MOUSE 79.487 0.974922 0.630435 Dpp7 - Dipeptidyl peptidase 2 precursor - Mus musculus (Mouse) - Dpp7 gene Plays an important role in the degradation of some oligopeptides. Taurus_UMD|evm.model.NW_003100262.1.1 Q6W4X9 MUC6_HUMAN 78.141 0.683391 0.236982 MUC6 - Mucin-6 precursor - Homo sapiens (Human) - MUC6 gene May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. Taurus_UMD|evm.model.NW_003100263.1.1 Q6W4X9 MUC6_HUMAN 82.866 0.891365 0.147191 MUC6 - Mucin-6 precursor - Homo sapiens (Human) - MUC6 gene May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. Taurus_UMD|evm.model.NW_003100264.1.1 Q6W4X9 MUC6_HUMAN 65.863 0.96875 0.104961 MUC6 - Mucin-6 precursor - Homo sapiens (Human) - MUC6 gene May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. Taurus_UMD|evm.model.NW_003100301.1.1 P22226 CTHL1_BOVIN 99.355 0.987179 1.00645 CATHL1 - Cathelicidin-1 precursor - Bos taurus (Bovine) - CATHL1 gene Potent microbicidal activity; active against S.aureus and E.coli. Taurus_UMD|evm.model.NW_003100301.1.2 P33046 CTHL4_BOVIN 100.000 0.986207 1.00694 CATHL4 - Cathelicidin-4 precursor - Bos taurus (Bovine) - CATHL4 gene Potent microbicidal activity; active against S.aureus and E.coli. Taurus_UMD|evm.model.NW_003100330.1.1 Q14954 KI2S1_HUMAN 53.261 0.5 0.598684 KIR2DS1 - Killer cell immunoglobulin-like receptor 2DS1 precursor - Homo sapiens (Human) - KIR2DS1 gene Receptor on natural killer (NK) cells for some HLA-C alleles such as w6. Does not inhibit the activity of NK cells. Taurus_UMD|evm.model.NW_003100346.1.1 Q02817 MUC2_HUMAN 74.109 0.997619 0.0810967 MUC2 - Mucin-2 precursor - Homo sapiens (Human) - MUC2 gene Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. Taurus_UMD|evm.model.NW_003100387.1.1 P0DOX3 IGD_HUMAN 54.500 0.760618 0.505859 Immunoglobulin delta heavy chain - Homo sapiens (Human) Taurus_UMD|evm.model.NW_003100415.1.1 P10950 ASMT_BOVIN 98.500 0.872807 0.66087 ASMT - Acetylserotonin O-methyltransferase - Bos taurus (Bovine) - ASMT gene Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Taurus_UMD|evm.model.NW_003100425.1.1 P63170 DYL1_RAT 84.146 0.55102 1.65169 Dynll1 - Dynein light chain 1, cytoplasmic - Rattus norvegicus (Rat) - Dynll1 gene Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Taurus_UMD|evm.model.NW_003100425.1.2 A0A0K0K1A5 TVB65_HUMAN 68.687 0.725926 1.18421 TRBV6-5 - T cell receptor beta variable 6-5 precursor - Homo sapiens (Human) - TRBV6-5 gene V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.NW_003100453.1.2 P31621 ENV_JSRV 48.913 0.98913 0.149593 env - Envelope glycoprotein precursor - Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) - env gene The envelope proteins induce cell transformation leading to ovine pulmonary adenocarcinoma (OPA), a contagious lung cancer of sheep and goat. They bind to the HYAL2 receptor for cell entry. Env proteins probably do not act as oncogenes by themselves, but may rather liberate an oncogenic factor that would normally be negatively regulated. One mechanism of transformation seems to involve activation of the phosphoinositide-3-OH kinase (PI3K)/Akt pathway but does not involve the virus receptor HYAL2, and the other seems to involve Env binding to HYAL2, HYAL2 degradation, and activation of the MST1R receptor tyrosine kinase, which is normally suppressed by HYAL2. Taurus_UMD|evm.model.NW_003100469.1.1 Q60813 ADM1A_MOUSE 61.488 0.944376 1.02276 Adam1a - Disintegrin and metalloproteinase domain-containing protein 1a precursor - Mus musculus (Mouse) - Adam1a gene May be involved in sperm-egg fusion. Taurus_UMD|evm.model.NW_003100493.1.1 A2AF47 DOC11_MOUSE 94.860 0.883817 0.116257 Dock11 - Dedicator of cytokinesis protein 11 - Mus musculus (Mouse) - Dock11 gene Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:15710388, PubMed:16968698, PubMed:25851601). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (PubMed:25729399). Facilitates filopodia formation through the activation of CDC42 (PubMed:22494997). Taurus_UMD|evm.model.NW_003100501.1.1 A1XQU1 PSB7_PIG 35.789 0.724409 0.458484 PSMB7 - Proteasome subunit beta type-7 precursor - Sus scrofa (Pig) - PSMB7 gene Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity. Taurus_UMD|evm.model.NW_003100508.1.1 P07352 IFNW1_BOVIN 89.231 0.877828 1.13333 IFNW1 - Interferon omega-1 precursor - Bos taurus (Bovine) - IFNW1 gene extracellular space, cytokine activity, type I interferon receptor binding, adaptive immune response, B cell differentiation, B cell proliferation, cytokine-mediated signaling pathway, humoral immune response, natural killer cell activation involved in immune response, positive regulation of peptidyl-serine phosphorylation of STAT protein Taurus_UMD|evm.model.NW_003100526.1.1 Q9Y5P8 P2R3B_HUMAN 61.739 0.990909 0.191304 PPP2R3B - Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Homo sapiens (Human) - PPP2R3B gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Taurus_UMD|evm.model.NW_003100558.1.1 E9Q236 MRP4_MOUSE 79.348 0.739837 0.0928302 Abcc4 - ATP-binding cassette sub-family C member 4 - Mus musculus (Mouse) - Abcc4 gene ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable). Taurus_UMD|evm.model.NW_003100560.1.1 P57016 LAD1_MOUSE 61.039 0.938272 0.153409 Lad1 - Ladinin-1 - Mus musculus (Mouse) - Lad1 gene Anchoring filament protein which is a component of the basement membrane zone. Taurus_UMD|evm.model.NW_003100561.1.1 P57016 LAD1_MOUSE 58.120 0.950413 0.229167 Lad1 - Ladinin-1 - Mus musculus (Mouse) - Lad1 gene Anchoring filament protein which is a component of the basement membrane zone. Taurus_UMD|evm.model.NW_003100566.1.1 Q5JUK9 PAGE3_HUMAN 47.778 0.927083 0.849558 PAGE3 - P antigen family member 3 - Homo sapiens (Human) - PAGE3 gene Taurus_UMD|evm.model.NW_003100663.1.1 Q9UPS8 ANR26_HUMAN 66.460 0.906433 0.1 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.NW_003100663.1.2 A2AS55 ANR16_MOUSE 35.789 0.731092 0.32964 Ankrd16 - Ankyrin repeat domain-containing protein 16 - Mus musculus (Mouse) - Ankrd16 gene Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity (PubMed:29769718). Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides (PubMed:29769718). Taurus_UMD|evm.model.NW_003100663.1.4 Q9UPS8 ANR26_HUMAN 63.551 0.883929 0.0654971 ANKRD26 - Ankyrin repeat domain-containing protein 26 - Homo sapiens (Human) - ANKRD26 gene Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. Taurus_UMD|evm.model.NW_003100680.1.1 A0A0B4J277 TVA22_HUMAN 60.674 0.871287 0.918182 TRAV22 - T cell receptor alpha variable 22 precursor - Homo sapiens (Human) - TRAV22 gene V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). Taurus_UMD|evm.model.NW_003100689.1.1 Q86VW0 SESD1_HUMAN 100.000 0.866667 0.215517 SESTD1 - SEC14 domain and spectrin repeat-containing protein 1 - Homo sapiens (Human) - SESTD1 gene May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1. Taurus_UMD|evm.model.NW_003100692.1.1 O75022 LIRB3_HUMAN 65.640 0.915217 0.729002 LILRB3 - Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor - Homo sapiens (Human) - LILRB3 gene May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). Taurus_UMD|evm.model.NW_003100695.1.1 P05980 PGFS1_BOVIN 85.882 0.94382 0.275542 Prostaglandin F synthase 1 - Bos taurus (Bovine) Taurus_UMD|evm.model.NW_003100697.1.1 O75022 LIRB3_HUMAN 63.658 0.913043 0.729002 LILRB3 - Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor - Homo sapiens (Human) - LILRB3 gene May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). Taurus_UMD|evm.model.NW_003100704.1.1 Q6PI73 LIRA6_HUMAN 64.516 0.533865 1.56549 LILRA6 - Leukocyte immunoglobulin-like receptor subfamily A member 6 precursor - Homo sapiens (Human) - LILRA6 gene May act as receptor for class I MHC antigens. Taurus_UMD|evm.model.NW_003100705.1.1 O75022 LIRB3_HUMAN 60.664 0.866242 0.746434 LILRB3 - Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor - Homo sapiens (Human) - LILRB3 gene May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). Taurus_UMD|evm.model.NW_003100714.1.1 O19110 TSPY1_BOVIN 68.231 0.952941 0.804416 TSPY1 - Testis-specific Y-encoded protein 1 - Bos taurus (Bovine) - TSPY1 gene May be involved in sperm differentiation and proliferation. Taurus_UMD|evm.model.NW_003100714.1.2 Q86YH2 Z280B_HUMAN 63.869 0.98008 0.462247 ZNF280B - Zinc finger protein 280B - Homo sapiens (Human) - ZNF280B gene May function as a transcription factor. Taurus_UMD|evm.model.NW_003100724.1.1 Q6ZQ12 NINL_MOUSE 60.233 0.923744 0.413917 Ninl - Ninein-like protein - Mus musculus (Mouse) - Ninl gene Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly (By similarity). Taurus_UMD|evm.model.NW_003100730.1.1 P0DMW5 SIL2B_HUMAN 93.103 0.721519 1.01282 SMIM10L2B - Small integral membrane protein 10-like protein 2B - Homo sapiens (Human) - SMIM10L2B gene Taurus_UMD|evm.model.NW_003100732.1.1 P29508 SPB3_HUMAN 56.364 0.981818 0.141026 SERPINB3 - Serpin B3 - Homo sapiens (Human) - SERPINB3 gene May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). Taurus_UMD|evm.model.NW_003100733.1.1 P48594 SPB4_HUMAN 69.298 0.918699 0.315385 SERPINB4 - Serpin B4 - Homo sapiens (Human) - SERPINB4 gene May act as a protease inhibitor to modulate the host immune response against tumor cells. Taurus_UMD|evm.model.NW_003100754.1.1 A0A075B6I6 LV150_HUMAN 64.516 0.73494 0.70339 IGLV1-50 - Probable non-functional immunoglobulin lambda variable 1-50 precursor - Homo sapiens (Human) - IGLV1-50 gene Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447). Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170). Taurus_UMD|evm.model.NW_003100762.1.1 P01820 HVM44_MOUSE 67.273 0.81203 1.15652 Ig heavy chain V region PJ14 precursor - Mus musculus (Mouse) Taurus_UMD|evm.model.NW_003100777.1.1 P10775 RINI_PIG 85.408 0.827957 0.611842 RNH1 - Ribonuclease inhibitor - Sus scrofa (Pig) - RNH1 gene Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. Taurus_UMD|evm.model.NW_003100802.1.1 P13164 IFM1_HUMAN 75.000 0.608247 0.776 IFITM1 - Interferon-induced transmembrane protein 1 - Homo sapiens (Human) - IFITM1 gene IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) (PubMed:26354436, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration (PubMed:33270927). Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). Taurus_UMD|evm.model.NW_003100805.1.1 Q86VF2 IGFN1_HUMAN 70.588 0.14841 0.452438 IGFN1 - Immunoglobulin-like and fibronectin type III domain-containing protein 1 - Homo sapiens (Human) - IGFN1 gene nucleus, synapse, Z disc, homophilic cell adhesion via plasma membrane adhesion molecules, retina layer formation, synapse assembly Taurus_UMD|evm.model.NW_003100862.1.1 Q9Y5P8 P2R3B_HUMAN 83.871 0.983871 0.107826 PPP2R3B - Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Homo sapiens (Human) - PPP2R3B gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Taurus_UMD|evm.model.NW_003100863.1.1 Q9NUJ7 PLCX1_HUMAN 80.292 0.98556 0.857585 PLCXD1 - PI-PLC X domain-containing protein 1 - Homo sapiens (Human) - PLCXD1 gene Taurus_UMD|evm.model.NW_003100864.1.1 O43824 GTPB6_HUMAN 79.493 0.943355 0.889535 GTPBP6 - Putative GTP-binding protein 6 - Homo sapiens (Human) - GTPBP6 gene cytoplasm, GTP binding, ribosome binding Taurus_UMD|evm.model.NW_003100865.1.1 Q9Y5P8 P2R3B_HUMAN 88.256 0.989324 0.488696 PPP2R3B - Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Homo sapiens (Human) - PPP2R3B gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Taurus_UMD|evm.model.NW_003100866.1.1 Q9Y5P8 P2R3B_HUMAN 91.935 0.946154 0.226087 PPP2R3B - Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Homo sapiens (Human) - PPP2R3B gene The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Taurus_UMD|evm.model.NW_003100874.1.1 P32007 ADT3_BOVIN 100.000 0.993311 1.00336 SLC25A6 - ADP/ATP translocase 3 - Bos taurus (Bovine) - SLC25A6 gene ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (By similarity). It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it (By similarity). Taurus_UMD|evm.model.NW_003100874.1.2 P26951 IL3RA_HUMAN 42.541 0.988827 0.94709 IL3RA - Interleukin-3 receptor subunit alpha precursor - Homo sapiens (Human) - IL3RA gene This is a receptor for interleukin-3. Taurus_UMD|evm.model.NW_003100968.1.1 Q96LI6 HSFY1_HUMAN 63.743 0.994118 0.42394 HSFY1 - Heat shock transcription factor, Y-linked - Homo sapiens (Human) - HSFY1 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.NW_003100974.1.1 Q96LI6 HSFY1_HUMAN 64.327 0.994118 0.42394 HSFY1 - Heat shock transcription factor, Y-linked - Homo sapiens (Human) - HSFY1 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.NW_003100989.1.1 Q96LI6 HSFY1_HUMAN 64.327 0.994118 0.42394 HSFY1 - Heat shock transcription factor, Y-linked - Homo sapiens (Human) - HSFY1 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II Taurus_UMD|evm.model.NW_003101018.1.1 Q96LI6 HSFY1_HUMAN 63.314 0.988095 0.418953 HSFY1 - Heat shock transcription factor, Y-linked - Homo sapiens (Human) - HSFY1 gene chromatin, nucleus, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, regulation of transcription by RNA polymerase II